Download | CGGA - Chinese Glioma Genome Atlas

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Download CGGA data

*It was updated on Jan 4, 2022, and older versions is available here.
Open access to single cell sequencing data from the CGGA network (6,148 cells from 73 regions of 13 glioma patients)

DataSet ID: scRNA-seq

Data type: Single-cell sequencing

Platform: STRT-seq

Total 6,148 cells, involving in 73 regions from 13 patients.

If you use this part of the data (or method included in it), please consider to cite:

1. Zhao, Z., Zhang, KN., Wang, QW., et al. Chinese Glioma Genome Atlas (CGGA): A Comprehensive Resource with Functional Genomic Data from Chinese Glioma Patients (2021). Genomics, Proteomics & Bioinformatics 19(1):1-12.
2. Yu, Kai., Hu, Yuqiong., Wu, Fan., et al. Surveying brain tumor heterogeneity by single-cell RNA-sequencing of multi-sector biopsies (2020). National Science Review 7(8):1306–1318

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Clinical Data [Total number of visits: 150]
scRNAseq UMI Count Matrix [Total number of visits: 142]
Raw Fastq Data (BIGD accession number: HRA000179)

DataSet ID: Spatiotemporal transcriptome data

Data type: mRNA sequencing

Platform: Illumina HiSeq

Total number of samples: Longitudinal samples: 141; Spatial samples: 67

If you use this part of the data (or method included in it), please consider to cite:

1. Zhao, Z., Zhang, KN., Wang, QW., et al. Chinese Glioma Genome Atlas (CGGA): A Comprehensive Resource with Functional Genomic Data from Chinese Glioma Patients (2021). Genomics, Proteomics & Bioinformatics 19(1):1-12.
2. Feng, J., Zhao, Z., Wei, Y., Bao, Z., et al. Temporal and Spatial Stability of the EM/PM Molecular Subtypes in Adult Diffuse Glioma. (To be submitted).

Further information and requests for resources should be directed to the Lead Contact, Tao Jiang or Xiaolong Fan (taojiang1964@163.com or xfan@bnu.edu.cn)

DataSet ID: Spatiotemporal WES data

Data type: Whole-exome sequencing

Platform: Agilent SureSelect kit v5.4 & Illumina HiSeq 4,000

Total number of samples: Longitudinal samples: 10; Spatial samples: 67

If you use this part of the data (or method included in it), please consider to cite:

1. Zhao, Z., Zhang, KN., Wang, QW., et al. Chinese Glioma Genome Atlas (CGGA): A Comprehensive Resource with Functional Genomic Data from Chinese Glioma Patients (2021). Genomics, Proteomics & Bioinformatics 19(1):1-12.
2. Yang, C., Tan, Y., Li, S., et al. (2019). Genomic landscapes by multiregion sequencing combined with circulation tumor DNA detection contribute to molecular diagnosis in glioblastomas. Aging 11, 11224-11243
3. Feng, J., Zhao, Z., Wei, Y., Bao, Z., et al. Temporal and Spatial Stability of the EM/PM Molecular Subtypes in Adult Diffuse Glioma. (To be submitted).

Further information and requests for resources should be directed to the Lead Contact, Tao Jiang or Xiaolong Fan (taojiang1964@163.com or xfan@bnu.edu.cn)

DataSet ID: Image-genomic data

Data type: Image-genomic data

Platform: MRI

Total number of samples: 274

If you use this part of the data (or method included in it), please consider to cite:

1. Zhao, Z., Zhang, KN., Wang, QW., et al. Chinese Glioma Genome Atlas (CGGA): A Comprehensive Resource with Functional Genomic Data from Chinese Glioma Patients (2021). Genomics, Proteomics & Bioinformatics 19(1):1-12.
2. Li, Y., Liang, Y., Sun, Z., et al. Radiogenomic analysis of PTEN mutation in glioblastoma using preoperative multi-parametric magnetic resonance imaging. Neuroradiology. 2019 Nov;61(11):1229-1237.

Further information and requests for resources should be directed to the Lead Contact, Tao Jiang (taojiang1964@163.com)

DataSet ID: WESeq_286

Data type: Whole-exome sequencing

Platform: Agilent SureSelect kit v5.4 & Illumina HiSeq 4,000

Total number of samples: 286

If you use this part of the data (or method included in it), please consider to cite:

1. Zhao, Z., Zhang, KN., Wang, QW., et al. Chinese Glioma Genome Atlas (CGGA): A Comprehensive Resource with Functional Genomic Data from Chinese Glioma Patients (2021). Genomics, Proteomics & Bioinformatics 19(1):1-12.
2. Hu, H., Mu, Q., Bao, Z., et al. (2018). Mutational Landscape of Secondary Glioblastoma Guides MET-Targeted Trial in Brain Tumor. Cell 175, 1665-1678 e1618.
3. Jiang, T., Mao, Y., Ma, W., et al. (2016). CGCG clinical practice guidelines for the management of adult diffuse gliomas. Cancer Lett 375(2):263-273.

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Clinical Data [Total number of visits: 2872]
Mutation Data from SAVI2 [Total number of visits: 2222]
Raw Fastq Data (BIGD accession number: PRJCA001636)

DataSet ID: mRNAseq_693

Data type: mRNA sequencing

Platform: Illumina HiSeq

Total number of samples: 693

If you use this part of the data (or method included in it), please consider to cite:

1. Zhao, Z., Zhang, KN., Wang, QW., et al. Chinese Glioma Genome Atlas (CGGA): A Comprehensive Resource with Functional Genomic Data from Chinese Glioma Patients (2021). Genomics, Proteomics & Bioinformatics 19(1):1-12.
2. Wang, Y., Qian, T., You, G., et al. (2015). Localizing seizure-susceptible brain regions associated with low-grade gliomas using voxel-based lesion-symptom mapping. NEURO-ONCOLOGY. 17(2): 282-288.
3. Liu, X., Li, Y., Qian, Z., et al. (2018). A radiomic signature as a non-invasive predictor of progression-free survival in patients with lower-grade gliomas. NEUROIMAGE-CLINICAL. 20(1070-1077.

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Clinical Data [Total number of visits: 6170]
Expression Data from STAR+RSEM [Total number of visits: 5945]
Raw Fastq Data (BIGD accession number: PRJCA001747)

DataSet ID: mRNAseq_325

Data type: mRNA sequencing

Platform: Illumina HiSeq 2000 or 2500

Total number of samples: 325

If you use this part of the data (or method included in it), please consider to cite:

1. Zhao, Z., Zhang, KN., Wang, QW., et al. Chinese Glioma Genome Atlas (CGGA): A Comprehensive Resource with Functional Genomic Data from Chinese Glioma Patients (2021). Genomics, Proteomics & Bioinformatics 19(1):1-12.
2. Bao, Z.S., Chen, H.M., Yang, M.Y., et al. (2014). RNA-seq of 272 gliomas revealed a novel, recurrent PTPRZ1-MET fusion transcript in secondary glioblastomas. Genome research 24, 1765-1773
3. Zhao, Z., Meng, F., Wang, W., et al. (2017). Comprehensive RNA-seq transcriptomic profiling in the malignant progression of gliomas. Scientific data 4, 170024

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Clinical Data [Total number of visits: 4726]
Expression Data from STAR+RSEM [Total number of visits: 4648]
Raw Fastq Data (BIGD accession number: PRJCA001746)

DataSet ID: mRNA-array_301

Data type: mRNA microarray

Platform: Agilent Whole Human Genome (Array)

Total number of samples: 301

If you use this part of the data (or method included in it), please consider to cite:

1. Zhao, Z., Zhang, KN., Wang, QW., et al. Chinese Glioma Genome Atlas (CGGA): A Comprehensive Resource with Functional Genomic Data from Chinese Glioma Patients (2021). Genomics, Proteomics & Bioinformatics 19(1):1-12.
2. Fang, S., Liang, J., Qian, T., et al. (2017). Anatomic Location of Tumor Predicts the Accuracy of Motor Function Localization in Diffuse Lower-Grade Gliomas Involving the Hand Knob Area. AMERICAN JOURNAL OF NEURORADIOLOGY. 38(10): 1990-1997
3. Wang, Y., Wang, Y., Fan, X., et al. (2017). Putamen involvement and survival outcomes in patients with insular low-grade gliomas. JOURNAL OF NEUROSURGERY. 126(6): 1788-1794.

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Clinical Data [Total number of visits: 2416]
Expression Data (gene level) [Total number of visits: 2404]
Expression Data (probe level) [Total number of visits: 1459]

DataSet ID: methyl_159

Data type: DNA methylation microarray

Platform: Illumina Infinium HumanMethylation27 Bead-Chips

Total number of samples: 159

If you use this part of the data (or method included in it), please consider to cite:

1. Zhao, Z., Zhang, KN., Wang, QW., et al. Chinese Glioma Genome Atlas (CGGA): A Comprehensive Resource with Functional Genomic Data from Chinese Glioma Patients (2021). Genomics, Proteomics & Bioinformatics 19(1):1-12.

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Clinical Data [Total number of visits: 1615]
Methylation Data (gene level) [Total number of visits: 1608]
Methylation Data (probe level) [Total number of visits: 1257]

DataSet ID: microRNA_198

Data type: microRNA microarray

Platform: human v2.0 miRNA Expression BeadChip (Illumina)

Total number of samples: 198

If you use this part of the data (or method included in it), please consider to cite:

1. Zhao, Z., Zhang, KN., Wang, QW., et al. Chinese Glioma Genome Atlas (CGGA): A Comprehensive Resource with Functional Genomic Data from Chinese Glioma Patients (2021). Genomics, Proteomics & Bioinformatics 19(1):1-12.

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Clinical Data [Total number of visits: 1675]
Expression Data (gene level) [Total number of visits: 1722]
Expression Data (probe level) [Total number of visits: 1257]

DataSet ID: mRNA sequencing (non-glioma as control)

Data type: Illumina HiSeq

Total number of samples: 20

If you use this part of the data (or method included in it), please consider to cite:

1. Zhao, Z., Zhang, KN., Wang, QW., et al. Chinese Glioma Genome Atlas (CGGA): A Comprehensive Resource with Functional Genomic Data from Chinese Glioma Patients (2021). Genomics, Proteomics & Bioinformatics 19(1):1-12.

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Expression Data from STAR+RSEM [Total number of visits: 1916]

*Browse the 'About' section for details of data processing

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