Welcome to the eccDNABase database

Extrachromosomal circular DNA (eccDNA) refers to small, circular DNA molecules that originate from chromosomal sequences and are prevalent across nearly all eukaryotic organisms. In humans, eccDNAs are widely distributed in normal tissues, cancerous tissues, and body fluids, where they play important roles in tumorigenesis and are often associated with poor clinical outcomes.

Our database contains 1,875,452 eccDNA-disease associations, encompassing 8,398 ecDNA entries across 9 species (Homo sapiens, Mouse, Chicken, Arabidopsis thaliana, Rice, Saccharomyces cerevisiae, Tomato, Cow and Amaranthus palmeri), 63 diseases, and healthy individuals. Our database is unique in several ways: (i) compared to published eccDNA databases, our database contains the highest amount of eccDNA entries, spanning across the most species and diseases; (ii) we integrate the latest published literature on eccDNA data; (iii) Each eccDNA entry in the database contains highly detailed information. Additionally, the database provides a comprehensive analysis of the gene overlaps based on both the hg19 and hg38 genome versions, including the overlap percentage of genes and the overlap percentage of eccDNA.