pmid	journal	pub_time	title	circrna_id	circrna_synonyms	circ_rna_name	host_gene	Disease_Details	Disease_MONDO_id	Disease_MONDO_name	expression_pattern	Detection_Method	description	Confidence Score
21151960	PLoS genetics	2010	Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk.		cANRIL / circular ANRIL	hsa_circ_CDKN2BAS	CDKN2BAS	atherosclerosis	MONDO:0005311	atherosclerosis	unknown	RT-qPCR	"Circular ANRIL (cANRIL) isoforms from the CDKN2BAS/ANRIL locus (notably junctions 14-5 and 4-6) are RNase R-resistant circular transcripts detectable across cell types and in primary peripheral blood T cells. Their expression correlates with ASVD risk genotype at rs10757278 and with INK4/ARF tumor suppressor transcript levels, suggesting that 9p21 variants may influence ASVD susceptibility by modulating ANRIL splicing/structure."	0.5841
24427167	Frontiers in genetics	2013	Circular RNA (circRNA) in Alzheimer's disease (AD).		ciRS-7			Alzheimer's disease	MONDO:0004975	Alzheimer disease	down-regulated	Northern Blot	"In sporadic AD hippocampal CA1, ciRS-7 is reduced. The study suggests this loss weakens miRNA-7 sponge activity, potentially increasing miRNA-7 and contributing to reduced expression of miRNA-7 target mRNAs such as UBE2A."	0.429
25624062	Scientific reports	2015	"Correlation of circular RNA abundance with proliferation--exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissues."		circ0817	hsa_circ_CUL5	CUL5	colorectal cancer	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"circ0817 (from CUL5) shows a reduced circRNA/linRNA ratio in CRC tumor tissue and an inverse (trend-level) association with proliferation (Ki-67), supporting a model where circRNA abundance decreases with higher proliferative activity."	0.4773
25624062	Scientific reports	2015	"Correlation of circular RNA abundance with proliferation--exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissues."		circ3204	hsa_circ_USP3	USP3	colorectal cancer	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"circ3204 (from USP3) exhibits a decreased circRNA/linRNA ratio in CRC tumor tissue and shows a trend of negative correlation with Ki-67 proliferation index, consistent with global circRNA reduction in proliferating cancer contexts."	0.4773
25624062	Scientific reports	2015	"Correlation of circular RNA abundance with proliferation--exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissues."		circ6229	hsa_circ_METTL3	METTL3	colorectal cancer	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"circ6229 (from METTL3) is decreased in CRC and its circ6229/METTL3 ratio is significantly negatively correlated with Ki-67 proliferation, supporting the study¡¯s model that circRNAs are diluted in proliferating cancer cells."	0.5662
25624062	Scientific reports	2015	"Correlation of circular RNA abundance with proliferation--exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissues."		circ7374	hsa_circ_TNS4	TNS4	colorectal cancer	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"circ7374 (from TNS4) is reported as up-regulated in CRC by RNA-seq, yet its circRNA/linRNA ratio is reduced in tumors and significantly inversely correlated with Ki-67 proliferation, consistent with proliferation-driven global reduction of circular-to-linear transcript ratios."	0.5662
25624062	Scientific reports	2015	"Correlation of circular RNA abundance with proliferation--exemplified with colorectal and ovarian cancer, idiopathic lung fibrosis, and normal human tissues."		circ7780			colorectal cancer	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"circ7780 (no annotated linear counterpart) is lower expressed in CRC tumor vs normal colon mucosa and shows a negative (non-significant) correlation with proliferation, aligning with the paper¡¯s proliferation-driven global circRNA reduction model."	0.5662
25749389	Oncotarget	2015	Circular RNA ITCH has inhibitory effect on ESCC by suppressing the Wnt/beta-catenin pathway.			hsa_circ_ITCH	ITCH	esophageal squamous cell carcinoma	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	RT-qPCR	"cir-ITCH is down-regulated in ESCC tissues and functions as a tumor suppressor. It sponges multiple miRNAs to increase ITCH, promoting degradation of phosphorylated Dvl2 and thereby inhibiting Wnt/beta-catenin signaling, reducing c-Myc and suppressing proliferation and tumor growth."	0.779
26110611	PloS one	2015	cir-ITCH plays an inhibitory role in colorectal cancer by regulating the Wnt/beta-catenin pathway.		cir-ITCH	hsa_circ_ITCH	ITCH	colorectal cancer	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"In colorectal cancer, cir-ITCH is down-regulated and functions as a tumor-suppressive circRNA. It acts as an miRNA sponge to modulate ITCH, leading to inhibition of Wnt/beta-catenin signaling and reduced expression of downstream targets (e.g., c-myc and cyclinD1), thereby suppressing CRC cell proliferation."	0.7769
26324352	Molecular medicine reports	2015	Cyclic RNA hsa_circ_000595 regulates apoptosis of aortic smooth muscle cells.		hsa_circ_000595			aortic aneurysm	MONDO:0005160	aortic aneurysm	up-regulated	RT-qPCR; Microarray	"hsa-circ-000595 is up-regulated in aortic aneurysm tissues and in hypoxia-treated human aortic smooth muscle cells. Functionally, silencing hsa-circ-000595 attenuates hypoxia-induced apoptosis. Mechanistically, hsa-circ-000595 negatively regulates miR-19a (reported as a target), linking the circRNA to miRNA-mediated regulation of apoptosis-associated proteins."	0.6093
26683098	Oncotarget	2016	Dysregulated miR-671-5p / CDR1-AS / CDR1 / VSNL1 axis is involved in glioblastoma multiforme.		CDR1-AS / ciRS-7	hsa_circ_CDR1	CDR1	glioblastoma multiforme	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR	"CDR1-AS is down-regulated in GBM biopsies and GBM cell lines. The study supports that miR-671-5p targets/degrades CDR1-AS, which is associated with reduced CDR1 and an altered axis contributing to GBM cell migratory/proliferative phenotypes."	0.4535
26931159	Scientific reports	2016	Circular RNA Related to the Chondrocyte ECM Regulates MMP13 Expression by Functioning as a MiR-136 'Sponge' in Human Cartilage Degradation.	hsa_circ_0023404	circRNA-CER / circRNA_100876	hsa_circ_RNF121	RNF121	osteoarthritis	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; Microarray	"circRNA-CER (circRNA_100876; hsa_circ_0023404; host gene RNF121) is up-regulated in osteoarthritis cartilage and in cytokine-stimulated chondrocytes. It promotes cartilage ECM degradation by acting as a ceRNA that sponges miR-136, thereby regulating MMP13 expression; knockdown reduces MMP13 and increases ECM markers (COL2 and aggrecan)."	0.6676
26931159	Scientific reports	2016	Circular RNA Related to the Chondrocyte ECM Regulates MMP13 Expression by Functioning as a MiR-136 'Sponge' in Human Cartilage Degradation.		hsa_circRNA_100086			osteoarthritis	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; Microarray	circRNA_100086 is overexpressed in osteoarthritis cartilage versus normal cartilage based on microarray screening and qPCR validation. No downstream mechanism or function was investigated for this circRNA in the study.	0.3588
26931159	Scientific reports	2016	Circular RNA Related to the Chondrocyte ECM Regulates MMP13 Expression by Functioning as a MiR-136 'Sponge' in Human Cartilage Degradation.		hsa_circRNA_101178			osteoarthritis	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; Microarray	circRNA_101178 is overexpressed in osteoarthritis cartilage versus normal cartilage based on microarray screening and qPCR validation. The study did not investigate its mechanism or biological function further.	0.3588
26931159	Scientific reports	2016	Circular RNA Related to the Chondrocyte ECM Regulates MMP13 Expression by Functioning as a MiR-136 'Sponge' in Human Cartilage Degradation.		circRNA_101914			osteoarthritis	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; Microarray	circRNA_101914 is overexpressed in osteoarthritis cartilage versus normal cartilage based on microarray screening and qPCR validation. No functional or mechanistic experiments for this circRNA were reported.	0.3588
26998750	PloS one	2016	The Circular RNA Cdr1as Promotes Myocardial Infarction by Mediating the Regulation of miR-7a on Its Target Genes Expression.		Cdr1as / CiRS-7	mmu_circ_Cdr1as	Cdr1as	myocardial infarction	MONDO:0005068	myocardial infarction	up-regulated	RT-qPCR	"Cdr1as is up-regulated in mouse myocardial infarction and in hypoxia-treated cardiomyocytes. It promotes cardiomyocyte apoptosis and worsens MI injury by sponging miR-7a, thereby relieving miR-7a-mediated repression of PARP and SP1."	0.6216
27050392	Nature communications	2016	Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs.		circHIPK3	hsa_circ_HIPK3	HIPK3	prostate adenocarcinoma	MONDO:0005082	prostate adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circHIPK3 (from HIPK3 exon2) is up-regulated in liver cancer and promotes human cell growth/proliferation. Mechanistically, it acts as a miRNA sponge binding nine miRNAs (notably miR-124), suppressing miR-124 activity and influencing downstream targets such as IL6R and DLX2."	0.8123
27050392	Nature communications	2016	Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs.		circHIPK3	hsa_circ_HIPK3	HIPK3	hepatocellular carcinoma	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circHIPK3 (from HIPK3 exon2) is up-regulated in liver cancer and promotes human cell growth/proliferation. Mechanistically, it acts as a miRNA sponge binding nine miRNAs (notably miR-124), suppressing miR-124 activity and influencing downstream targets such as IL6R and DLX2."	0.8123
27050392	Nature communications	2016	Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs.		circHIPK3	hsa_circ_HIPK3	HIPK3	bladder transitional cell carcinoma	MONDO:0005611	bladder transitional cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circHIPK3 (from HIPK3 exon2) is up-regulated in liver cancer and promotes human cell growth/proliferation. Mechanistically, it acts as a miRNA sponge binding nine miRNAs (notably miR-124), suppressing miR-124 activity and influencing downstream targets such as IL6R and DLX2."	0.8123
27050392	Nature communications	2016	Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs.		circHIPK3	hsa_circ_HIPK3	HIPK3	 breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	"circHIPK3 (from HIPK3 exon2) is up-regulated in liver cancer and promotes human cell growth/proliferation. Mechanistically, it acts as a miRNA sponge binding nine miRNAs (notably miR-124), suppressing miR-124 activity and influencing downstream targets such as IL6R and DLX2."	0.8123
27050392	Nature communications	2016	Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs.		circHIPK3	hsa_circ_HIPK3	HIPK3	colorectal cancer	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"circHIPK3 (from HIPK3 exon2) is up-regulated in liver cancer and promotes human cell growth/proliferation. Mechanistically, it acts as a miRNA sponge binding nine miRNAs (notably miR-124), suppressing miR-124 activity and influencing downstream targets such as IL6R and DLX2."	0.8123
27050392	Nature communications	2016	Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs.		circHIPK3	hsa_circ_HIPK3	HIPK3	gastric cancer	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"circHIPK3 (from HIPK3 exon2) is up-regulated in liver cancer and promotes human cell growth/proliferation. Mechanistically, it acts as a miRNA sponge binding nine miRNAs (notably miR-124), suppressing miR-124 activity and influencing downstream targets such as IL6R and DLX2."	0.8123
27050392	Nature communications	2016	Circular RNA profiling reveals an abundant circHIPK3 that regulates cell growth by sponging multiple miRNAs.		circHIPK3	hsa_circ_HIPK3	HIPK3	 clear cell renal carcinoma	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR; RNA-seq	"circHIPK3 (from HIPK3 exon2) is up-regulated in liver cancer and promotes human cell growth/proliferation. Mechanistically, it acts as a miRNA sponge binding nine miRNAs (notably miR-124), suppressing miR-124 activity and influencing downstream targets such as IL6R and DLX2."	0.8123
27058418	Oncotarget	2016	Emerging roles of circRNA_001569 targeting miR-145 in the proliferation and invasion of colorectal cancer.		hsa_circ_001569	hsa_circ_ABCC1	ABCC1	colorectal cancer	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_001569 (hsa_circ_001569) is up-regulated in colorectal cancer tissues and promotes CRC cell proliferation and invasion while inhibiting apoptosis and cell-cycle arrest. Mechanistically, it functions as a miR-145 sponge, reducing miR-145 activity and thereby increasing downstream targets E2F5, BAG4 and FMNL2; its high expression is associated with aggressive clinicopathologic features."	0.7177
27258521	Medicine	2016	"Comprehensive Circular RNA Profiling Reveals That hsa_circ_0005075, a New Circular RNA Biomarker, Is Involved in Hepatocellular Crcinoma Development."	hsa_circ_0005075				hepatocellular carcinoma	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0005075 is significantly up-regulated in HCC tissues and is associated with larger tumor size, suggesting a tumor-promoting role. Mechanistically, it is predicted to act as a miRNA sponge (e.g., hsa-miR-23b-5p, hsa-miR-93-3p, hsa-miR-581, hsa-miR-23a-5p) and to be involved in a miRNA_mRNA network enriched for cell-adhesion-related processes. It shows strong diagnostic potential for distinguishing HCC from adjacent nontumorous tissues (AUROC 0.94)."	0.6556
27391479	PloS one	2016	The Circular RNA Cdr1as Act as an Oncogene in Hepatocellular Carcinoma through Targeting miR-7 Expression.		Cdr1as / ciRS-7	hsa_circ_CDR1AS		hepatocellular carcinoma	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"Cdr1as is up-regulated in HCC tissues and HCC cell lines. Functionally, Cdr1as promotes HCC cell proliferation and invasion, at least partly by targeting miR-7 and affecting miR-7 downstream targets (e.g., CCNE1 and PIK3CD)."	0.5358
27465405	Journal of translational medicine	2016	Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells.		hsa_circRNA_100385	hsa_circ_PRRX1	PRRX1	esophageal cancer	MONDO:0007576	esophageal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_100385 is significantly up-regulated in the radioresistant esophageal cancer cell line KYSE-150R compared with the parental KYSE-150 cells. The study reports it as part of the dysregulated circRNA profile associated with radioresistance, without a specific validated mechanism for this circRNA."	0.1904
27465405	Journal of translational medicine	2016	Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells.		hsa_circRNA_104983	hsa_circ_NHS	NHS	esophageal cancer	MONDO:0007576	esophageal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_104983 is up-regulated in radioresistant esophageal cancer KYSE-150R cells versus KYSE-150. The paper reports it among the top up-regulated circRNAs, without further mechanistic validation specific to this circRNA."	0.1904
27465405	Journal of translational medicine	2016	Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells.		hsa_circRNA_001059	hsa_circ_LIN52	LIN52	esophageal cancer	MONDO:0007576	esophageal cancer	up-regulated	RT-qPCR; Microarray	"circRNA_001059 (LIN52-derived) is up-regulated in radioresistant KYSE-150R cells and is identified as a key node in the circRNA_miRNA co-expression network. The study proposes it may inhibit multiple miRNAs (miRNA sponge-like role), suggesting involvement in radioresistance, but without downstream target gene validation."	0.2465
27465405	Journal of translational medicine	2016	Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells.		hsa_circRNA_101877	hsa_circ_RFWD3	RFWD3	esophageal cancer	MONDO:0007576	esophageal cancer	down-regulated	RT-qPCR; Microarray	hsa_circRNA_101877 (RFWD3-derived) is down-regulated in the radioresistant KYSE-150R esophageal cancer cells compared with KYSE-150. The study reports differential expression but does not provide a specific mechanism for this circRNA.	0.1904
27465405	Journal of translational medicine	2016	Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells.		hsa_circRNA_102913	hsa_circ_ATIC	ATIC	esophageal cancer	MONDO:0007576	esophageal cancer	down-regulated	RT-qPCR; Microarray	hsa_circRNA_102913 (ATIC-derived) is down-regulated in radioresistant KYSE-150R cells compared with KYSE-150. The paper reports differential expression but no specific mechanism for this circRNA.	0.1904
27465405	Journal of translational medicine	2016	Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells.		hsa_circRNA_000695	hsa_circ_EEFSEC	EEFSEC	esophageal cancer	MONDO:0007576	esophageal cancer	down-regulated	RT-qPCR; Microarray	hsa_circRNA_000695 (EEFSEC-derived) is down-regulated in radioresistant KYSE-150R esophageal cancer cells compared with KYSE-150. The study reports differential expression but no specific mechanistic role for this circRNA.	0.1904
27465405	Journal of translational medicine	2016	Profiling and bioinformatics analyses reveal differential circular RNA expression in radioresistant esophageal cancer cells.		hsa_circRNA_000167	hsa_circ_RPPH1	RPPH1	esophageal cancer	MONDO:0007576	esophageal cancer	down-regulated	RT-qPCR; Microarray	"circRNA_000167 (RPPH1-derived) is down-regulated in radioresistant KYSE-150R cells and is highlighted as a major node in the circRNA_miRNA co-expression network. The study suggests it may be a key circRNA related to radioresistance, but does not experimentally validate its downstream targets."	0.2465
27484176	Scientific reports	2016	Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma.	hsa_circ_0041103	circTCF25	hsa_circ_TCF25	TCF25	bladder carcinoma	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"circTCF25 is up-regulated in bladder carcinoma and promotes proliferation and migration. Mechanistically, it sequesters miR-103a-3p/miR-107, leading to increased CDK6 expression (and additional predicted oncogenic targets), supporting a ceRNA-like regulatory role and potential biomarker value."	0.6528
27484176	Scientific reports	2016	Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma.	hsa_circ_0007158	circFAM169A	hsa_circ_FAM169A	FAM169A	bladder carcinoma	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; Microarray	"circFAM169A (hsa_circ_0007158) is significantly down-regulated in bladder carcinoma tissues compared with matched para-carcinoma tissues and was among the six circRNAs validated by qRT-PCR, suggesting potential diagnostic value."	0.5541
27484176	Scientific reports	2016	Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma.	hsa_circ_0082582	circTRIM24	hsa_circ_TRIM24	TRIM24	bladder carcinoma	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; Microarray	"circTRIM24 (hsa_circ_0082582) is significantly down-regulated in bladder carcinoma tissues compared with matched para-carcinoma tissues and was among the six circRNAs validated by qRT-PCR, indicating potential diagnostic relevance."	0.5541
27484176	Scientific reports	2016	Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma.	hsa_circ_0072088	circZFR	hsa_circ_ZFR	ZFR	bladder carcinoma	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"circZFR (hsa_circ_0072088) is significantly up-regulated in bladder carcinoma tissues and was validated by qRT-PCR in clinical paired samples, suggesting potential diagnostic relevance."	0.5541
27484176	Scientific reports	2016	Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma.	hsa_circ_0005273	circPTK2	hsa_circ_PTK2	PTK2	bladder carcinoma	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"circPTK2 (hsa_circ_0005273) is significantly up-regulated in bladder carcinoma tissues and was validated by qRT-PCR in clinical paired samples, suggesting potential diagnostic relevance."	0.5541
27484176	Scientific reports	2016	Screening differential circular RNA expression profiles reveals the regulatory role of circTCF25-miR-103a-3p/miR-107-CDK6 pathway in bladder carcinoma.	hsa_circ_0061265	circBC048201			bladder carcinoma	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"circBC048201 (hsa_circ_0061265) is significantly up-regulated in bladder carcinoma tissues and was validated by qRT-PCR in clinical paired samples, suggesting potential diagnostic relevance."	0.5541
27539542	Nature communications	2016	Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans.		circANRIL	hsa_circ_ANRIL	ANRIL	atherosclerosis	MONDO:0005311	atherosclerosis	unknown	RT-qPCR; Microarray	"circANRIL (from the ANRIL/CDKN2B-AS1 locus at 9p21) is associated with CAD-protective genotype and lower CAD burden. Mechanistically, it binds PES1 in the PeBoW complex, inhibits pre-rRNA processing and ribosome biogenesis, triggers nucleolar stress and p53 activation, thereby promoting apoptosis and suppressing proliferation in atherogenesis-relevant human vascular cells."	0.8913
27604105	Archives of toxicology	2017	"A novel regulatory network among LncRpa, CircRar1, MiR-671 and apoptotic genes promotes lead-induced neuronal cell apoptosis."		circRar1	mmu_circ_Rar1		neurotoxicity	MONDO:0005527	toxic encephalopathy	up-regulated	RT-qPCR; RNA-seq	"circRar1 is upregulated in lead-induced neurotoxicity (mouse brain regions and PbAc-treated N2a cells) and promotes neuronal apoptosis. Mechanistically, it localizes to the cytoplasm and directly interacts with miR-671, modulating miR-671 and thereby increasing pro-apoptotic targets such as caspase8 and p38."	0.734
27613831	Oncotarget	2016	Silencing of cZNF292 circular RNA suppresses human glioma tube formation via the Wnt/beta-catenin signaling pathway.		cZNF292	hsa_circ_ZNF292	ZNF292	glioma 	MONDO:0021042	glioma	unknown	RT-qPCR	"In human glioma cell lines, cZNF292 supports proliferation, cell-cycle progression and tube formation. Knockdown of cZNF292 induces S/G2/M arrest and suppresses Wnt/beta-catenin-related signaling and downstream effectors (e.g., Cyclin A/CDK2/PRR11) as well as tube formation-associated factors (VEGFR-1/2, EGFR)."	0.5301
27642589	BioMed research international	2016	Circular RNA-ITCH Suppresses Lung Cancer Proliferation via Inhibiting the Wnt/beta-Catenin Pathway.			hsa_circ_ITCH	ITCH	lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	"cir-ITCH is down-regulated in lung cancer tissues. It suppresses lung cancer cell proliferation by sponging miR-7 and miR-214, increasing ITCH expression and inhibiting Wnt/beta-catenin signaling (reduced beta-catenin/TCF activity and downstream c-Myc/cyclinD1)."	0.7769
27677588	Oncotarget	2016	CircRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of nonalcoholic steatohepatitis.		circRNA_002581			nonalcoholic steatohepatitis	MONDO:0007027	metabolic dysfunction-associated steatohepatitis	up-regulated	RT-qPCR; Microarray	"circRNA_002581 is up-regulated in MCD diet-induced NASH mouse liver and is proposed to act as a miRNA sponge in a qRT-PCR-verified circRNA-miRNA-mRNA network, involving miR-122 and downstream mRNAs Slc1a5, Plp2 and Cpeb1."	0.6579
27677588	Oncotarget	2016	CircRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of nonalcoholic steatohepatitis.		circRNA_007585			nonalcoholic steatohepatitis	MONDO:0007027	metabolic dysfunction-associated steatohepatitis	up-regulated	RT-qPCR; Microarray	"circRNA_007585 is up-regulated in MCD diet-induced NASH mouse liver and is part of a qRT-PCR-verified circRNA-miRNA-mRNA axis (circRNA_007585/miR-326/UCP2), suggesting a potential ceRNA-related involvement linked to UCP2-associated mitochondrial dysfunction in NASH."	0.5495
27713910	Oncoscience	2016	The anti-cancer components of Ganoderma lucidum possesses cardiovascular protective effect by regulating circular RNA expression.			mmu_circ_Foxo3	Foxo3	cardiomyopathy	MONDO:0004994	cardiomyopathy	down-regulated	RT-qPCR	"In the TAC mouse model of pressure overload-induced cardiomyopathy/heart failure, Ganoderma spore oil treatment reduced cardiac circ-Foxo3 expression. This reduction was also observed in mouse cardiac fibroblasts in a dose- and time-dependent manner."	0.3513
27752108	Scientific reports	2016	Circular RNA has_circ_0067934 is upregulated in esophageal squamous cell carcinoma and promoted proliferation.	hsa_circ_0067934		hsa_circ_PRKCI	PRKCI	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"hsa_circ_0067934 is up-regulated in ESCC tumor tissues and ESCC cell lines. Its knockdown suppresses proliferation, migration and invasion, and causes G2-phase cell-cycle arrest, suggesting an oncogenic role in ESCC and potential as a biomarker/therapeutic target."	0.675
27892494	Scientific reports	2016	Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes.		circFAT1 / chr4:187627717-187630999	hsa_circ_FAT1	FAT1	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"circFAT1 is consistently reduced in KRAS-mutant colon/colorectal cancer cell lines compared with KRAS WT counterparts and is detectable in exosomes, where it also shows lower abundance in mutant-derived exosomes in at least one comparison."	0.4773
27892494	Scientific reports	2016	Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes.		HIPK3 / chr11:33307959-33309057	hsa_circ_HIPK3	HIPK3	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"The HIPK3-derived circRNA is decreased in KRAS-mutant colon/colorectal cancer cell lines versus KRAS WT controls and is detectable in exosomes, supporting a KRAS-mutation-associated global reduction of circRNA abundance."	0.3401
27892494	Scientific reports	2016	Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes.		ARHGAP5 / chr14:32559708-32563592 / circARHGAP5	hsa_circ_ARHGAP5	ARHGAP5	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	The ARHGAP5-derived circRNA is reduced in KRAS-mutant colon/colorectal cancer cells relative to KRAS WT controls and is also reported as reduced in KRAS-mutant exosomes in the exosomal comparison.	0.3401
27892494	Scientific reports	2016	Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes.		MAN1A2 / chr1:117944808-117963271	hsa_circ_MAN1A2	MAN1A2	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"The MAN1A2-derived circRNA is decreased in KRAS-mutant colon/colorectal cancer cell lines versus KRAS WT controls and is detectable in exosomes, consistent with global circRNA reduction in KRAS-mutant contexts."	0.3401
27892494	Scientific reports	2016	Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes.		RHOBTB3 / chr5:95091100-95099324	hsa_circ_RHOBTB3	RHOBTB3	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"The RHOBTB3-derived circRNA is reduced in KRAS-mutant colon/colorectal cancer cell lines versus KRAS WT controls and is detectable in exosomes, aligning with the study¡¯s conclusion of global circRNA down-regulation in KRAS-mutant cells."	0.3401
27892494	Scientific reports	2016	Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes.		RTN4 / chr2:55209651-55214834 / circRTN4	hsa_circ_RTN4	RTN4	colorectal cancer 	MONDO:0005575	colorectal cancer	dysregulated	RT-qPCR; RNA-seq	"The RTN4-derived circRNA shows context-dependent changes: it is reduced in KRAS-mutant DLD-1 cells relative to KRAS WT controls but increased in DLD-1-derived exosomes, indicating dysregulated cellular vs exosomal distribution/abundance associated with KRAS mutation status."	0.3401
27892494	Scientific reports	2016	Circular RNAs are down-regulated in KRAS mutant colon cancer cells and can be transferred to exosomes.		SMARCA5 / chr4:144464662-144465125	hsa_circ_SMARCA5	SMARCA5	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"The SMARCA5-derived circRNA is reduced in KRAS-mutant colon/colorectal cancer cell lines relative to KRAS WT controls and is present in exosomes, supporting KRAS-mutation-associated circRNA down-regulation."	0.3401
27903978	Oncotarget	2017	Circular RNA ZNF609 functions as a competitive endogenous RNA to regulate AKT3 expression by sponging miR-150-5p in Hirschsprung's disease.	hsa_circ_0000615	cir-ZNF609 / circular RNA ZNF609 / circRNA ZNF609	hsa_circ_ZNF609	ZNF609	Hirschsprung disease 	MONDO:0018309	Hirschsprung disease	down-regulated	RT-qPCR	"cir-ZNF609 is down-regulated in HSCR colon/bowel tissues and its knockdown inhibits cell proliferation and migration in 293T and SH-SY5Y cells. Mechanistically, cir-ZNF609 mainly localizes to the cytoplasm and acts as a ceRNA by sponging miR-150-5p, thereby modulating AKT3 expression, suggesting diagnostic potential for HSCR."	0.8703
27929395	Genes	2016	Deficiency in the Ubiquitin Conjugating Enzyme UBE2A in Alzheimer's Disease (AD) is Linked to Deficits in a Natural Circular miRNA-7 Sponge (circRNA; ciRS-7).		ciRS-7	hsa_circ_CDR1AS		Alzheimer¡¯s disease	MONDO:0004975	Alzheimer disease	down-regulated	Northern Blot	"In sporadic Alzheimer¡¯s disease brain (neocortex A22 and hippocampal CA1), ciRS-7 is markedly down-regulated. Loss of this miRNA-7 sponge is linked to increased ambient miRNA-7 and reduced expression of miRNA-7-sensitive targets such as UBE2A, implicating a disrupted circRNA/miRNA/mRNA regulatory circuit relevant to AD pathology."	0.429
27965971	International journal of genomics	2016	Profiling of the Predicted Circular RNAs in Ductal In Situ and Invasive Breast Cancer: A Pilot Study.	hsa_circ_0001358	hsa-circ-001803	hsa_circ_SEC62	SEC62	breast cancer 	MONDO:0007254	breast cancer	unknown	RNA-seq	"This study computationally identified SEC62-derived hsa-circ-0001358 in synchronous DCIS/IDC and predicted it may act as a miRNA sponge (e.g., miR-200 family). Correlation analyses suggested potential links with EMT-related targets (positive with BMI-1 and negative with FN1), supporting a preliminary circRNA/miRNA/mRNA axis hypothesis in DCIS-to-IDC progression."	0.1768
27965971	International journal of genomics	2016	Profiling of the Predicted Circular RNAs in Ductal In Situ and Invasive Breast Cancer: A Pilot Study.	hsa_circ_0122662	hsa-circ-0122662	hsa_circ_SEC62	SEC62	breast cancer	MONDO:0007254	breast cancer	unknown	RNA-seq	This study identified SEC62-derived hsa-circ-0122662 from RNA-seq data in synchronous DCIS/IDC (and referenced MCF7 circRNA profiling) but reported no predicted miRNA interactions for this circRNA. No validated functional or clinical role was established.	0.1768
28003761	OncoTargets and therapy	2016	"Comprehensive profile of differentially expressed circular RNAs reveals that hsa_circ_0000069 is upregulated and promotes cell proliferation, migration, and invasion in colorectal cancer."	hsa_circ_0000069				colorectal cancer	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"hsa_circ_0000069 is upregulated in colorectal cancer tissues/cell lines. Its knockdown suppresses CRC cell proliferation, migration and invasion, and induces G0/G1 cell-cycle arrest in vitro, suggesting an oncogenic role and potential diagnostic/therapeutic relevance."	0.5751
28045102	Scientific reports	2017	Peripheral blood circular RNA hsa_circ_0124644 can be used as a diagnostic biomarker of coronary artery disease.	hsa_circ_0124644				coronary artery disease	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR; Microarray	"hsa_circ_0124644 is significantly up-regulated in peripheral/whole blood of CAD patients versus controls and shows diagnostic value by ROC analysis across multiple cohorts. The study suggests it may reflect CAD severity (correlated with SYNTAX score), while its biological function/mechanism in CAD remains unvalidated."	0.5047
28045102	Scientific reports	2017	Peripheral blood circular RNA hsa_circ_0124644 can be used as a diagnostic biomarker of coronary artery disease.	hsa_circ_0098964				coronary artery disease	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR; Microarray	hsa_circ_0098964 is up-regulated in peripheral/whole blood of CAD patients. It serves as a diagnostic biomarker and increases diagnostic performance when combined with hsa_circ_0124644 (higher AUC by ROC analysis).	0.4679
28045102	Scientific reports	2017	Peripheral blood circular RNA hsa_circ_0124644 can be used as a diagnostic biomarker of coronary artery disease.	hsa_circ_0082081				coronary artery disease	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR; Microarray	hsa_circ_0082081 is up-regulated in peripheral/whole blood of CAD patients and shows modest diagnostic performance by ROC analysis. No mechanism or functional role was experimentally investigated for this circRNA in the study.	0.4679
28045102	Scientific reports	2017	Peripheral blood circular RNA hsa_circ_0124644 can be used as a diagnostic biomarker of coronary artery disease.	hsa_circ_0113854				coronary artery disease	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR; Microarray	hsa_circ_0113854 is up-regulated in peripheral/whole blood of CAD patients and has limited diagnostic value by ROC analysis. The study did not establish a mechanistic role for this circRNA in CAD.	0.4679
28045102	Scientific reports	2017	Peripheral blood circular RNA hsa_circ_0124644 can be used as a diagnostic biomarker of coronary artery disease.		hsa-circRNA5974-1			coronary artery disease	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR; Microarray	hsa-circRNA5974-1 is up-regulated in peripheral/whole blood of CAD patients and shows moderate diagnostic value by ROC analysis. No mechanistic experiments were reported for this circRNA in CAD.	0.4679
28081541	British journal of cancer	2017	Circular RNA 0000096 affects cell growth and migration in gastric cancer.	hsa_circ_0000096		hsa_circ_HIAT1	HIAT1	gastric cancer	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"hsa_circ_0000096 is significantly down-regulated in gastric cancer tissues and cell lines and has diagnostic potential (ROC AUC 0.82). Functional knockdown experiments indicate it supports cell-cycle progression, proliferation, and migration, accompanied by reduced cyclin D1/CDK6 and MMP-2/MMP-9; a ceRNA relationship with miR-200a/miR-224 is suggested."	0.722
28167847	Disease markers	2017	Decreased Expression of Hsa_circ_00001649 in Gastric Cancer and Its Clinical Significance.	hsa_circ_0001649		hsa_circ_SHPRH	SHPRH	gastric cancer	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"hsa_circ_0001649 (host gene SHPRH) is significantly down-regulated in gastric cancer tissues versus paired nontumorous tissues, and increases in serum after surgery. It shows diagnostic potential for GC (ROC AUC 0.834) and is associated with pathological differentiation, but no molecular mechanism was experimentally defined."	0.6238
28174233	Clinical cancer research : an official journal of the American Association for Cancer Research	2017	Circular RNA ciRS-7-A Promising Prognostic Biomarker and a Potential Therapeutic Target in Colorectal Cancer.			hsa_circ_CDR1AS		colorectal cancer	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"ciRS-7 is up-regulated in colorectal cancer and functions as an oncogenic circRNA. It sponges miR-7, relieving repression of EGFR and RAF1 and promoting EGFR/RAF1/MAPK signaling, which enhances malignant phenotypes and is associated with poor patient survival."	0.7528
28206972	Oncotarget	2017	Circular RNAs signature predicts the early recurrence of stage III gastric cancer after radical surgery.		hsa_circRNA_101308			gastric cancer	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	hsa_circRNA_101308 is one of four circRNAs forming a classifier that stratifies stage III gastric cancer patients into high- vs low-risk groups for early postoperative recurrence. It is higher in recurrent vs non-recurrent tumors and contributes positively to the recurrence risk score.	0.7034
28206972	Oncotarget	2017	Circular RNAs signature predicts the early recurrence of stage III gastric cancer after radical surgery.		hsacircRNA_104423			gastric cancer	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	hsa_circRNA_104423 is one component of a four-circRNA classifier for predicting early recurrence in stage III gastric cancer. It is lower in recurrent vs non-recurrent tumors and contributes negatively to the recurrence risk score (higher expression corresponds to lower predicted recurrence risk in the model).	0.7034
28206972	Oncotarget	2017	Circular RNAs signature predicts the early recurrence of stage III gastric cancer after radical surgery.		hsa_circRNA_104916			gastric cancer	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	hsa_circRNA_104916 is included in a four-circRNA recurrence-risk classifier for stage III gastric cancer. It is lower in recurrent vs non-recurrent tumors and contributes negatively to the recurrence risk score.	0.7034
28206972	Oncotarget	2017	Circular RNAs signature predicts the early recurrence of stage III gastric cancer after radical surgery.		hsa_circRNA_100269			gastric cancer	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	hsa_circRNA_100269 is part of a four-circRNA model that predicts early recurrence in stage III gastric cancer after radical surgery. It is down in recurrent vs non-recurrent tumors and contributes negatively to the recurrence risk score.	0.7034
28211215	Molecular oncology	2017	"ZKSCAN1 gene and its related circular RNA (circZKSCAN1) both inhibit hepatocellular carcinoma cell growth, migration, and invasion but through different signaling pathways."	hsa_circ_0001727		hsa_circ_ZKSCAN1	ZKSCAN1	hepatocellular carcinoma	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; ISH; RNA-seq	"circZKSCAN1 is down-regulated in hepatocellular carcinoma tissues and cell lines and acts as a tumor suppressor by inhibiting proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, it is mainly cytoplasmic and is proposed to act as a ceRNA affecting PI3K- and migration-related gene programs, and it shows diagnostic potential (AUC 0.834) for distinguishing tumor from adjacent tissue."	0.7999
28219405	Journal of hematology & oncology	2017	TTBK2 circular RNA promotes glioma malignancy by regulating miR-217/HNF1beta/Derlin-1 pathway.	hsa_circ_0000594		hsa_circ_TTBK2	TTBK2	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; ISH	"circ-TTBK2 is up-regulated in glioma tissues/cells and promotes malignant phenotypes (proliferation, migration, invasion) while inhibiting apoptosis. Mechanistically, it sponges miR-217 in an Ago2/RISC-dependent manner, thereby derepressing the miR-217 target HNF1beta and its downstream effector Derlin-1, with involvement of PI3K/AKT and ERK signaling and in vivo tumor growth effects."	0.817
28236760	Translational oncology	2017	Differential Expression of Circular RNAs in Glioblastoma Multiforme and Its Correlation with Prognosis.		circBRAF	hsa_circ_BRAF	BRAF	glioma	MONDO:0021042	glioma	down-regulated	RT-qPCR; RNA-seq	"circBRAF (derived from BRAF exon 8-13) is down-regulated in glioma/GBM tissues compared with normal brain. Higher circBRAF expression correlates with lower WHO grade and independently predicts better PFS and OS, supporting its potential as a prognostic/pathological-grade biomarker; no specific mechanistic axis was experimentally defined."	0.6656
28249903	Cancer research	2017	Noncoding Effects of Circular RNA CCDC66 Promote Colon Cancer Growth and Metastasis.			hsa_circ_CCDC66	CCDC66	colorectal cancer	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"circCCDC66 (circCCDC66_10_8) is up-regulated in colorectal/colon cancer tissues (including polyps) and its high expression predicts poorer overall survival. Functionally, it promotes proliferation, migration, invasion, anchorage-independent growth and metastasis, and its knockdown suppresses tumor growth and liver nodule formation in xenograft/orthotopic models. Mechanistically, it acts as a miRNA sponge (e.g., for miR-33b and miR-93), protecting oncogene mRNAs such as MYC and increasing oncogenic programs."	0.8824
28249903	Cancer research	2017	Noncoding Effects of Circular RNA CCDC66 Promote Colon Cancer Growth and Metastasis.		circCCNB1_7_6	hsa_circ_CCNB1	CCNB1	colorectal cancer	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circCCNB1_7_6 is significantly up-regulated in colorectal cancer tumor tissues versus paired adjacent non-tumor tissues, and was part of a panel of selected circRNAs validated as bona fide circRNAs. No downstream function or mechanism for circCCNB1_7_6 was further investigated in this study."	0.5531
28249903	Cancer research	2017	Noncoding Effects of Circular RNA CCDC66 Promote Colon Cancer Growth and Metastasis.		circCDK13_2_2	hsa_circ_CDK13	CDK13	colorectal cancer	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circCDK13_2_2 is significantly up-regulated in colorectal cancer tumor tissues versus paired adjacent non-tumor tissues, and was part of a panel of selected circRNAs validated as bona fide circRNAs. The study did not further characterize its functional mechanism beyond expression enrichment in CRC."	0.5531
28272342	International journal of molecular sciences	2017	The Characterization of GSDMB Splicing and Backsplicing Profiles Identifies Novel Isoforms and a Circular RNA That Are Dysregulated in Multiple Sclerosis.	hsa_circ_0106803		hsa_circ_GSDMB	GSDMB	multiple sclerosis 	MONDO:0005301	multiple sclerosis	up-regulated	RT-qPCR	"A GSDMB exonic circular RNA consisting of backspliced exons 5 and 4 (hsa_circ_0106803) is significantly up-regulated in PBMCs from RR-MS patients versus controls. The study validates its circular nature by divergent RT-PCR, Sanger sequencing of the back-splice junction, and RNase R resistance, and suggests it could serve as an MS biomarker; potential miRNA binding (e.g., miR-1275, miR-149) is computationally predicted but not functionally validated."	0.6291
28282919	International journal of molecular sciences	2017	Characterization of hsa_circ_0004277 as a New Biomarker for Acute Myeloid Leukemia via Circular RNA Profile and Bioinformatics Analysis.	hsa_circ_0004277		hsa_circ_WDR37	WDR37	acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	down-regulated	RT-qPCR; Microarray	"hsa_circ_0004277 is significantly down-regulated in newly diagnosed AML bone marrow samples, restored in complete remission after chemotherapy, and down-regulated again in relapsed-refractory cases. It shows strong diagnostic potential (AUC 0.957) and is proposed to function via a predicted miRNA-sponge circRNA_miRNA_mRNA network (e.g., involving miR-138-5p/miR-30c-1-3p and targets such as SH3GL2, PPARGC1A, and SH2B3)."	0.5963
28288173	PloS one	2017	Microarray profiling of circular RNAs in human papillary thyroid carcinoma.	hsa_circ_0004458	hsa_circRNA_104566			papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circRNA_104566 (hsa_circ_0004458) is significantly up-regulated in papillary thyroid carcinoma tumor tissues compared with controls in both microarray profiling and RT-qPCR validation. It is computationally predicted to contain miRNA response elements for several miRNAs including hsa-miR-329-5p and hsa-miR-205-3p.	0.5135
28288173	PloS one	2017	Microarray profiling of circular RNAs in human papillary thyroid carcinoma.	hsa_circ_0002111	hsa_circRNA_104565			papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_104565 (hsa_circ_0002111) is significantly up-regulated in papillary thyroid carcinoma tumor tissues compared with controls, supported by microarray profiling and RT-qPCR validation. It is bioinformatically predicted to interact with multiple miRNAs including hsa-miR-329-5p and hsa-miR-205-3p."	0.5135
28288173	PloS one	2017	Microarray profiling of circular RNAs in human papillary thyroid carcinoma.	hsa_circ_0008016	hsa_circRNA_104595			papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_104595 (hsa_circ_0008016) is significantly up-regulated in papillary thyroid carcinoma tumor tissues and was validated by RT-qPCR after microarray profiling. It is predicted to harbor binding sites for miRNAs such as hsa-miR-412-3p and hsa-miR-196b-3p, but no direct downstream functional validation is provided in this study."	0.5135
28288173	PloS one	2017	Microarray profiling of circular RNAs in human papillary thyroid carcinoma.	hsa_circ_0004771	hsa_circRNA_103110			papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_103110 (hsa_circ_0004771) is significantly up-regulated in papillary thyroid carcinoma tumor tissues based on microarray profiling and RT-qPCR validation. It is predicted to interact with miRNAs including hsa-miR-339-5p and hsa-miR-330-5p, but no downstream experimental mechanism was validated."	0.5135
28288173	PloS one	2017	Microarray profiling of circular RNAs in human papillary thyroid carcinoma.	hsa_circ_0091894	hsa_circRNA_105038			papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circRNA_105038 (hsa_circ_0091894) is significantly up-regulated in papillary thyroid carcinoma tumor tissues in microarray profiling and RT-qPCR validation. It is computationally predicted to interact with miRNAs including hsa-miR-329-5p and hsa-miR-339-5p.	0.5135
28288173	PloS one	2017	Microarray profiling of circular RNAs in human papillary thyroid carcinoma.	hsa_circ_0092315	hsa_circRNA_400064			papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circRNA_400064 (hsa_circ_0092315) is significantly up-regulated in papillary thyroid carcinoma tumor tissues based on microarray profiling and RT-qPCR validation. It is predicted to interact with miRNAs including hsa-miR-494-3p and hsa-miR-675-5p.	0.5135
28288173	PloS one	2017	Microarray profiling of circular RNAs in human papillary thyroid carcinoma.	hsa_circ_0078738	hsa_circRNA_104268			papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circRNA_104268 (hsa_circ_0078738) is significantly up-regulated in papillary thyroid carcinoma tumor tissues based on microarray profiling and RT-qPCR validation. It is predicted to interact with miRNAs including hsa-miR-646 and hsa-miR-214-3p.	0.5135
28288173	PloS one	2017	Microarray profiling of circular RNAs in human papillary thyroid carcinoma.	hsa_circ_0064557	hsa_circRNA_103307			papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circRNA_103307 (hsa_circ_0064557) is significantly up-regulated in papillary thyroid carcinoma tumor tissues in microarray profiling and RT-qPCR validation. It is predicted to interact with miRNAs including hsa-miR-23a-3p and hsa-miR-23b-3p.	0.5135
28288173	PloS one	2017	Microarray profiling of circular RNAs in human papillary thyroid carcinoma.	hsa_circ_0000516	hsa_circRNA_001379			papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circRNA_001379 (hsa_circ_0000516) is significantly up-regulated in papillary thyroid carcinoma tumor tissues based on microarray profiling and RT-qPCR validation. It is predicted to bind miRNAs including hsa-miR-125b-5p and hsa-miR-125a-3p.	0.5135
28288173	PloS one	2017	Microarray profiling of circular RNAs in human papillary thyroid carcinoma.	hsa_circ_0004846	hsa_circRNA_101356			papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circRNA_101356 (hsa_circ_0004846) is significantly up-regulated in papillary thyroid carcinoma tumor tissues based on microarray profiling and RT-qPCR validation. It is predicted to bind miRNAs including hsa-miR-646 and hsa-miR-148b-5p.	0.5135
28288173	PloS one	2017	Microarray profiling of circular RNAs in human papillary thyroid carcinoma.	hsa_circ_0003505	hsa_circRNA_102002			papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circRNA_102002 (hsa_circ_0003505) is significantly up-regulated in papillary thyroid carcinoma tumor tissues based on microarray profiling and RT-qPCR validation. It is predicted to interact with miRNAs such as hsa-miR-143-3p and hsa-miR-141-5p.	0.5135
28288173	PloS one	2017	Microarray profiling of circular RNAs in human papillary thyroid carcinoma.	hsa_circ_0081342	hsa_circRNA_104433			papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circRNA_104433 (hsa_circ_0081342) is significantly up-regulated in papillary thyroid carcinoma tumor tissues based on microarray profiling and RT-qPCR validation. It is predicted to interact with miRNAs including hsa-miR-15a-5p and hsa-miR-497-5p.	0.5135
28288173	PloS one	2017	Microarray profiling of circular RNAs in human papillary thyroid carcinoma.	hsa_circ_0021553	hsa_circRNA_100777			papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR; Microarray	hsa_circRNA_100777 (hsa_circ_0021553) is significantly down-regulated in papillary thyroid carcinoma tumor tissues based on microarray profiling and RT-qPCR validation. It is predicted to interact with miRNAs including hsa-miR-122-5p and hsa-miR-574-5p.	0.5135
28288173	PloS one	2017	Microarray profiling of circular RNAs in human papillary thyroid carcinoma.	hsa_circ_0015278	hsa_circRNA_100395			papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_100395 (hsa_circ_0015278) is significantly down-regulated in PTC tumor tissues and was validated by RT-qPCR. Bioinformatics analyses predict it binds miR-141-3p and miR-200a-3p and may affect cancer-related target genes including E2F3, PTEN, and CCND2 through a putative circRNA/miRNA/mRNA axis."	0.5135
28288173	PloS one	2017	Microarray profiling of circular RNAs in human papillary thyroid carcinoma.	hsa_circ_0079891	hsa_circRNA_104348			papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR; Microarray	hsa_circRNA_104348 (hsa_circ_0079891) is significantly down-regulated in papillary thyroid carcinoma tumor tissues based on microarray profiling and RT-qPCR validation. It is predicted to interact with miRNAs including hsa-miR-301a-3p and hsa-miR-100-3p.	0.5135
28288173	PloS one	2017	Microarray profiling of circular RNAs in human papillary thyroid carcinoma.	hsa_circ_0067103	hsa_circRNA_103454			papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR; Microarray	hsa_circRNA_103454 (hsa_circ_0067103) is significantly down-regulated in papillary thyroid carcinoma tumor tissues based on microarray profiling and RT-qPCR validation. It is predicted to interact with miRNAs including hsa-miR-7-5p and hsa-miR-144-5p.	0.5135
28368401	Oncogene	2017	circRNA_100290 plays a role in oral cancer by functioning as a sponge of the miR-29 family.		hsa_circRNA_100290 	hsa_circ_SLC30A7	SLC30A7	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circRNA_100290 is up-regulated in OSCC tissues/cell lines and promotes OSCC cell-cycle progression and proliferation as well as tumor growth in vivo. Mechanistically, it acts as a ceRNA/miRNA sponge for the miR-29 family (miR-29a/b/c), thereby relieving miR-29-mediated repression of CDK6 and sustaining CDK6 expression."	0.8174
28410211	Oncotarget	2017	Hsa_circ_0005986 inhibits carcinogenesis by acting as a miR-129-5p sponge and is used as a novel biomarker for hepatocellular carcinoma.	hsa_circ_0005986		hsa_circ_PRDM2	PRDM2	hepatocellular carcinoma	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"In hepatocellular carcinoma, hsa_circ_0005986 is down-regulated in tumors and HCC cell lines. It acts as a ceRNA sponge for miR-129-5p to modulate NOTCH1 mRNA, and its knockdown promotes cell-cycle progression and proliferation. Clinically, low hsa_circ_0005986 expression correlates with multiple aggressive clinicopathological features and is proposed as a diagnostic biomarker."	0.7082
28415618	Oncotarget	2017	Circular RNA alterations are involved in resistance to avian leukosis virus subgroup-J-induced tumor formation in chickens.		chr13:15110945-15122920-	gga_circ_JADE2	JADE2	ALV-J-induced tumor formation	MONDO:0025381	avian leukosis	up-regulated	RNA-seq	"This circRNA (JADE2-derived) is up-regulated in ALV-J-resistant chickens versus susceptible chickens, and is part of the set of resistance-associated circRNAs. The study predicts it may act through circRNA_miRNA_gene networks enriched for immune-related functions (including mTOR-associated targets)."	0.2414
28415618	Oncotarget	2017	Circular RNA alterations are involved in resistance to avian leukosis virus subgroup-J-induced tumor formation in chickens.		chr9:22282452-22289593-	gga_circ_LEKR1	LEKR1	ALV-J-induced tumor formation	MONDO:0025381	avian leukosis	up-regulated	RNA-seq	"This LEKR1-derived circRNA is up-regulated in ALV-J-resistant chickens and was used to build a predicted circRNA_miRNA_gene interaction network, suggesting a potential ceRNA role in resistance-associated immune pathways."	0.2414
28415618	Oncotarget	2017	Circular RNA alterations are involved in resistance to avian leukosis virus subgroup-J-induced tumor formation in chickens.		chr19:6585504-6585731+	gga_circ_UbI	UbI	ALV-J-induced tumor formation	MONDO:0025381	avian leukosis	up-regulated	RNA-seq	"This UbI-derived circRNA is up-regulated in ALV-J-resistant chickens and is part of the resistance-associated circRNA set, with predicted miRNA interactions linked to immune-related target genes."	0.2414
28415618	Oncotarget	2017	Circular RNA alterations are involved in resistance to avian leukosis virus subgroup-J-induced tumor formation in chickens.		chr3:105132799-105136715-	gga_circ_NCOA1	NCOA1	ALV-J-induced tumor formation	MONDO:0025381	avian leukosis	up-regulated	RNA-seq	"This NCOA1-derived circRNA is up-regulated in ALV-J-resistant chickens and was used for circRNA_miRNA_gene network construction, supporting a predicted ceRNA involvement in resistance-related immune processes."	0.2414
28415618	Oncotarget	2017	Circular RNA alterations are involved in resistance to avian leukosis virus subgroup-J-induced tumor formation in chickens.		chr1:179476699-179479760+	gga_circ_KDELC2	KDELC2	ALV-J-induced tumor formation	MONDO:0025381	avian leukosis	up-regulated	RNA-seq	"This KDELC2-derived circRNA is up-regulated in ALV-J-resistant chickens and has predicted binding miRNAs, suggesting a potential role in resistance-associated regulatory networks."	0.2414
28415618	Oncotarget	2017	Circular RNA alterations are involved in resistance to avian leukosis virus subgroup-J-induced tumor formation in chickens.		chr15:469774-490727+	gga_circ_PPM1F	PPM1F	ALV-J-induced tumor formation	MONDO:0025381	avian leukosis	up-regulated	RNA-seq	"This PPM1F-derived circRNA is up-regulated in ALV-J-resistant chickens, with predicted miRNA interactions whose targets are enriched in immune-related pathways, suggesting a potential role in ALV-J tumor resistance."	0.2414
28415618	Oncotarget	2017	Circular RNA alterations are involved in resistance to avian leukosis virus subgroup-J-induced tumor formation in chickens.		chr1:194735582-194744050-	gga_circ_RAB6A	RAB6A	ALV-J-induced tumor formation	MONDO:0025381	avian leukosis	up-regulated	RT-qPCR; RNA-seq	"This RAB6A-derived circRNA is up-regulated in ALV-J-resistant chickens and its differential expression was validated by qRT-PCR. It has predicted binding miRNAs, supporting a potential role in resistance-associated circRNA_miRNA_gene regulation linked to immune pathways."	0.4685
28415618	Oncotarget	2017	Circular RNA alterations are involved in resistance to avian leukosis virus subgroup-J-induced tumor formation in chickens.		chr18:11114003-11114452-	gga_circ_CASKIN2	CASKIN2	ALV-J-induced tumor formation	MONDO:0025381	avian leukosis	up-regulated	RNA-seq	"This CASKIN2-derived circRNA is up-regulated in ALV-J-resistant chickens and has predicted miRNA interactions, suggesting a potential regulatory role in resistance to ALV-J-induced tumor formation."	0.2414
28415618	Oncotarget	2017	Circular RNA alterations are involved in resistance to avian leukosis virus subgroup-J-induced tumor formation in chickens.		chr13:2807735-2827999-	gga_circ_RANBP17	RANBP17	ALV-J-induced tumor formation	MONDO:0025381	avian leukosis	up-regulated	RNA-seq	"This RANBP17-derived circRNA is up-regulated in ALV-J-resistant chickens and has predicted top-5 miRNA targets, indicating potential involvement in resistance-associated regulatory networks."	0.2414
28415618	Oncotarget	2017	Circular RNA alterations are involved in resistance to avian leukosis virus subgroup-J-induced tumor formation in chickens.		chr3:43666306-43724228-	gga_circ_PACRG	PACRG	ALV-J-induced tumor formation	MONDO:0025381	avian leukosis	up-regulated	RNA-seq	"This PACRG-derived circRNA is up-regulated in ALV-J-resistant chickens and was used for predicted circRNA_miRNA_gene network construction, suggesting a potential ceRNA role linked to immune-associated targets in resistance."	0.2414
28415618	Oncotarget	2017	Circular RNA alterations are involved in resistance to avian leukosis virus subgroup-J-induced tumor formation in chickens.		chr23:5549365-5549645-	gga_circ_HMGCL	HMGCL	ALV-J-induced tumor formation	MONDO:0025381	avian leukosis	up-regulated	RT-qPCR; RNA-seq	"This HMGCL-derived circRNA is up-regulated in ALV-J-resistant chickens and its differential expression was validated by qRT-PCR. It has predicted miRNA interactions, supporting a potential role in resistance-associated circRNA_miRNA_gene regulation."	0.4685
28415618	Oncotarget	2017	Circular RNA alterations are involved in resistance to avian leukosis virus subgroup-J-induced tumor formation in chickens.		chr2:816575-817682+	gga_circ_SMARCC1	SMARCC1	ALV-J-induced tumor formation	MONDO:0025381	avian leukosis	up-regulated	RNA-seq	"This SMARCC1-derived circRNA is up-regulated in ALV-J-resistant chickens and has predicted miRNA interactions, implying a potential role in resistance-associated immune regulatory networks."	0.2414
28424426	Oncotarget	2017	"Circular RNA hsa-circ-0016347 promotes proliferation, invasion and metastasis of osteosarcoma cells."	hsa_circ_0016347		hsa_circ_KCNH1	KCNH1	osteosarcoma	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ-0016347 is up-regulated in osteosarcoma tissues and cell lines and promotes osteosarcoma cell proliferation, invasion and metastasis. Mechanistically, it functions as a ceRNA/miRNA sponge for miR-214, thereby increasing caspase-1 expression and contributing to inflammation-related tumor progression."	0.6542
28435295	OncoTargets and therapy	2017	Silencing CDR1as inhibits colorectal cancer progression through regulating microRNA-7.		CDR1as	hsa_circ_CDR1	CDR1	colorectal cancer	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"CDR1as is up-regulated in colorectal cancer and high expression is associated with worse overall survival. Functionally, CDR1as promotes CRC proliferation and invasion by partially antagonizing miR-7, thereby sustaining EGFR and IGF-1R expression."	0.648
28484086	Oncotarget	2017	Identification of circular RNAs as a promising new class of diagnostic biomarkers for human breast cancer.	hsa_circ_0004771	hsa_circ_103110	hsa_circ_NRIP1	NRIP1	breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	hsa_circ_103110 (circBase: hsa_circ_0004771) is up-regulated in breast cancer tissues and is proposed to contribute to carcinogenesis mainly through predicted miRNA binding (MREs/miRNA sponge-like regulation).	0.5963
28484086	Oncotarget	2017	Identification of circular RNAs as a promising new class of diagnostic biomarkers for human breast cancer.	hsa_circ_0001824	hsa_circ_104689	hsa_circ_ASAP1	ASAP1	breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_104689 (circBase: hsa_circ_0001824), derived from ASAP1, is up-regulated in breast cancer tissues and is proposed to contribute to carcinogenesis mainly via predicted circRNA_miRNA interactions."	0.5963
28484086	Oncotarget	2017	Identification of circular RNAs as a promising new class of diagnostic biomarkers for human breast cancer.	hsa_circ_0001875	hsa_circ_104821	hsa_circ_FAM120A	FAM120A	breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_104821 (circBase: hsa_circ_0001875), derived from FAM120A, is up-regulated in breast cancer tissues and is suggested to act through predicted miRNA binding/MRE-mediated regulation."	0.5963
28484086	Oncotarget	2017	Identification of circular RNAs as a promising new class of diagnostic biomarkers for human breast cancer.	hsa_circ_0006054	hsa_circ_006054	hsa_circ_KIAA0355	KIAA0355	breast cancer	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_006054 (circBase: hsa_circ_0006054) is down-regulated in breast cancer tissues and was evaluated as a diagnostic biomarker, contributing to an AUC of 0.82 when combined with hsa_circ_100219 and hsa_circ_406697; its mechanistic role is suggested via predicted miRNA binding."	0.5963
28484086	Oncotarget	2017	Identification of circular RNAs as a promising new class of diagnostic biomarkers for human breast cancer.	hsa_circ_0004619	hsa_circ_100219	hsa_circ_FAF1	FAF1	breast cancer	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_100219 (circBase: hsa_circ_0004619) is down-regulated in breast cancer tissues and showed the best diagnostic performance (AUC 0.78) among the tested circRNAs; it is predicted to bind several miRNAs (including miR-135b-3p, miR-298, miR-485-3p)."	0.5963
28484086	Oncotarget	2017	Identification of circular RNAs as a promising new class of diagnostic biomarkers for human breast cancer.		hsa_circ_406697	hsa_circ_RBM22	RBM22	breast cancer	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_406697 is down-regulated in breast cancer tissues and, when combined with hsa_circ_006054 and hsa_circ_100219, improves diagnostic discrimination (AUC 0.82); it is predicted to interact with several miRNAs including hsa-miR-100-3p."	0.5963
28514762	Oncotarget	2017	Novel circular RNA expression profiles reflect progression of patients with hypopharyngeal squamous cell carcinoma.	hsa_circ_0058106		hsa_circ_FN1	FN1	hypopharyngeal squamous cell carcinoma	MONDO:0044638	hypopharynx squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0058106 is up-regulated in HSCC tumor tissues and was validated by qRT-PCR. The study predicts it may act as a miRNA sponge (e.g., miR-185-3p, miR-4638-3p) within circRNA-miRNA-mRNA networks, potentially influencing apoptosis-related behavior, but functional effects were not experimentally tested."	0.585
28514762	Oncotarget	2017	Novel circular RNA expression profiles reflect progression of patients with hypopharyngeal squamous cell carcinoma.	hsa_circ_0058107		hsa_circ_FN1	FN1	hypopharyngeal squamous cell carcinoma	MONDO:0044638	hypopharynx squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circ_0058107 is up-regulated in HSCC tumor tissues and was validated by qRT-PCR. It is predicted to sponge multiple miRNAs (including miR-185-3p) in circRNA-miRNA-mRNA networks; the anti-apoptotic implication is discussed but not experimentally validated.	0.585
28514762	Oncotarget	2017	Novel circular RNA expression profiles reflect progression of patients with hypopharyngeal squamous cell carcinoma.	hsa_circ_0024108		hsa_circ_MMP1	MMP1	hypopharyngeal squamous cell carcinoma	MONDO:0044638	hypopharynx squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0024108 is up-regulated in HSCC tumor tissues and was validated by qRT-PCR. The study predicts it participates in circRNA-miRNA-mRNA networks and may act as a ceRNA, potentially sponging miR-623 and miR-185-3p, but no direct functional experiments were performed."	0.585
28514762	Oncotarget	2017	Novel circular RNA expression profiles reflect progression of patients with hypopharyngeal squamous cell carcinoma.	hsa_circ_0036722		hsa_circ_RHCG	RHCG	hypopharyngeal squamous cell carcinoma	MONDO:0044638	hypopharynx squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0036722 is down-regulated in HSCC tumor tissues and was validated by qRT-PCR. The paper predicts it may participate in circRNA-miRNA networks (e.g., with miR-671-5p) that could relate to HSCC invasiveness, but the mechanism is not experimentally validated."	0.585
28514762	Oncotarget	2017	Novel circular RNA expression profiles reflect progression of patients with hypopharyngeal squamous cell carcinoma.	hsa_circ_0002260		hsa_circ_PAPD4	PAPD4	hypopharyngeal squamous cell carcinoma	MONDO:0044638	hypopharynx squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0002260 is down-regulated in HSCC tumor tissues and was validated by qRT-PCR. The study predicts miRNA binding (miR-1229-5p, miR-1301-3p) and places it in circRNA-miRNA-mRNA networks, but provides no functional validation."	0.585
28514762	Oncotarget	2017	Novel circular RNA expression profiles reflect progression of patients with hypopharyngeal squamous cell carcinoma.	hsa_circ_0001189		hsa_circ_MORC3	MORC3	hypopharyngeal squamous cell carcinoma	MONDO:0044638	hypopharynx squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0001189 is down-regulated in HSCC tumor tissues and was validated by qRT-PCR. It is predicted to bind miRNAs (miR-3127-3p, miR-5088-3p, miR-6756-3p) as part of circRNA-miRNA-mRNA networks, but no functional experiments were reported."	0.585
28544609	Cancer medicine	2017	Global circular RNA expression profile of human gastric cancer and its clinical significance.	hsa_circ_0014717				gastric cancer	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0014717 is significantly down-regulated in gastric cancer tissues and is associated with clinicopathological factors (tumor stage, distal metastasis, tissue CEA and CA19-9). It can be detected stably in gastric juice and shows diagnostic potential in tissue (ROC AUC 0.696), suggesting utility as a biomarker for screening/high-risk stratification."	0.6556
28624198	Molecular therapy. Nucleic acids	2017	Emerging Roles of circRNA Related to the Mechanical Stress in Human Cartilage Degradation of Osteoarthritis.	hsa_circ_0005567	hsa_circ_100226	hsa_circ_EPS15	EPS15	osteoarthritis	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; Microarray	"In osteoarthritis cartilage, circRNA-MSR (hsa_circ_100226; EPS15-derived) is upregulated in damaged regions and increases under mechanical stress in primary chondrocytes. Loss-of-function via siRNA reduces TNF-alpha and restores ECM markers, and bioinformatics suggests it may act as a miRNA sponge (notably involving miR-875) to modulate TNF-alpha."	0.4852
28624198	Molecular therapy. Nucleic acids	2017	Emerging Roles of circRNA Related to the Mechanical Stress in Human Cartilage Degradation of Osteoarthritis.		hsa_circRNA_000598			osteoarthritis	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; Microarray	circRNA_000598 was validated by RT-qPCR to be overexpressed in damaged versus intact osteoarthritic cartilage.	0.3588
28624198	Molecular therapy. Nucleic acids	2017	Emerging Roles of circRNA Related to the Mechanical Stress in Human Cartilage Degradation of Osteoarthritis.		hsa_circRNA_103387			osteoarthritis	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; Microarray	circRNA_103387 was validated by RT-qPCR to be overexpressed in damaged versus intact osteoarthritic cartilage.	0.3588
28624198	Molecular therapy. Nucleic acids	2017	Emerging Roles of circRNA Related to the Mechanical Stress in Human Cartilage Degradation of Osteoarthritis.		hsa_circRNA_101975			osteoarthritis	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; Microarray	circRNA_101975 was validated by RT-qPCR to be overexpressed in damaged versus intact osteoarthritic cartilage.	0.3588
28636993	Oncotarget	2017	Polymorphisms and expression pattern of circular RNA circ-ITCH contributes to the carcinogenesis of hepatocellular carcinoma.		circ-ITCH	hsa_circ_ITCH	ITCH	hepatocellular carcinoma	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"circ-ITCH is down-regulated in HCC tumor tissues versus adjacent tissues and is associated with HCC susceptibility. Higher circ-ITCH expression predicts better overall survival, supporting a tumor-suppressive role in HCC; mechanistic details were not experimentally explored in this study (Wnt/beta-catenin inhibition is discussed mainly from prior literature)."	0.6023
28644873	PloS one	2017	Circular RNA expression profiling of human granulosa cells during maternal aging reveals novel transcripts associated with assisted reproductive technology outcomes.		hsa_circRNA_103829	hsa_circ_HMGCS1	HMGCS1	aging			up-regulated	RT-qPCR; Microarray	"circRNA_103829 (hsa_circRNA_103829) is up-regulated in granulosa cells from advanced-age women compared with young women, and its level is also higher in women receiving high doses of gonadotropins. No downstream mechanism or clinical prediction model was established for this circRNA in the study."	0.4032
28644873	PloS one	2017	Circular RNA expression profiling of human granulosa cells during maternal aging reveals novel transcripts associated with assisted reproductive technology outcomes.		hsa_circRNA_103827	hsa_circ_HMGCS1	HMGCS1	aging			up-regulated	RT-qPCR; Microarray	"circRNA_103827 (hsa_circRNA_103827, from HMGCS1) is up-regulated in granulosa cells from older women and correlates with reduced ovarian reserve indicators (AMH, AFC) and poorer embryo outcomes. Its expression level in granulosa cells shows ROC-based predictive value for clinical pregnancy and live birth after ART, and bioinformatics suggests a potential ceRNA (miRNA sponge) role affecting targets such as ANKRD20A9P, KCNQ1OT1, and XIST, with links to glucose metabolism, mitotic cell cycle, and ovarian steroidogenesis."	0.6841
28644873	PloS one	2017	Circular RNA expression profiling of human granulosa cells during maternal aging reveals novel transcripts associated with assisted reproductive technology outcomes.		hsa_circRNA_104816	hsa_circ_IARS	IARS	aging			up-regulated	RT-qPCR; Microarray	"circRNA_104816 (hsa_circRNA_104816, from IARS) is up-regulated in granulosa cells from older women and is associated with reduced ovarian reserve measures and poorer embryo outcomes. It has ROC-based predictive value for clinical pregnancy and live birth after ART, and bioinformatics suggests it may act via a ceRNA mechanism involving miRNAs and predicted targets such as ANKRD20A9P, KCNQ1OT1, and XIST, linked to glucose metabolism, mitotic cell cycle, and ovarian steroidogenesis."	0.6841
28644873	PloS one	2017	Circular RNA expression profiling of human granulosa cells during maternal aging reveals novel transcripts associated with assisted reproductive technology outcomes.		hsa_circRNA_101889	hsa_circ_USP10	USP10	aging			down-regulated	RT-qPCR; Microarray	"circRNA_101889 (hsa_circRNA_101889, from USP10) is down-regulated in granulosa cells from advanced-age women compared with young women. Its expression is affected by gonadotropin treatment type, and the study did not establish a specific mechanistic pathway or clinical predictive utility for this circRNA."	0.3588
28656150	BioMed research international	2017	Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells.	hsa_circ_0007031		hsa_circ_TUBGCP3	TUBGCP3	colorectal cancer	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0007031 is strongly upregulated in 5-FU-based chemoradiation-resistant CRC cells and is predicted to act through miRNA-mediated regulation (e.g., involving miR-885-3p). It is also predicted (as a top upregulated circRNA) to influence cancer-related targets such as AKT3 and BCL2, potentially contributing to chemoradiation resistance."	0.2465
28656150	BioMed research international	2017	Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells.	hsa_circ_0000504		hsa_circ_TUBGCP3	TUBGCP3	colorectal cancer	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000504 is upregulated in 5-FU-based chemoradiation-resistant CRC cells and was validated by qRT-PCR. The study proposes that it may interact with hsa-miR-485-5p, relieving miRNA-mediated repression of STAT3 and thereby accelerating development of chemoradiation resistance; it is also predicted to regulate AKT3/BCL2-related cancer pathways."	0.2465
28656150	BioMed research international	2017	Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells.	hsa_circ_0007006		hsa_circ_DYM	DYM	colorectal cancer	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0007006 is upregulated in 5-FU-based chemoradiation-resistant CRC cells and its differential expression was validated by qRT-PCR. As one of the top three upregulated circRNAs, it is predicted to regulate AKT3 via miRNA-mediated interactions, potentially stabilizing AKT signaling in chemoradiation resistance."	0.2465
28656150	BioMed research international	2017	Microarray Analysis of Circular RNA Expression Profile Associated with 5-Fluorouracil-Based Chemoradiation Resistance in Colorectal Cancer Cells.	hsa_circ_0048234				colorectal cancer	MONDO:0005575	colorectal cancer	down-regulated	Microarray	"hsa_circ_0048234 is discussed as a downregulated circRNA with predicted miR-671-5p binding sites. The authors suggest that its downregulation could increase EGFR signaling and promote chemoradiation resistance, but this is presented as a possibility rather than experimentally validated in this study."	0.1768
28657541	Aging	2017	CircRNA_100269 is downregulated in gastric cancer and suppresses tumor cell growth by targeting miR-630.		CircRNA_100269	hsa_circ_LPHN2	LPHN2	gastric cancer	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"circRNA_100269 is down-regulated in gastric cancer tissues and GC cell lines. It directly interacts with miR-630, negatively correlates with miR-630 in tissues, and its overexpression inhibits GC cell proliferation; this anti-proliferative effect is reversed by miR-630 mimics."	0.7544
28682884	Medicine	2017	Microarray expression profile of circular RNAs in chronic thromboembolic pulmonary hypertension.	hsa_circ_0002062				chronic thromboembolic pulmonary hypertension	MONDO:0013024	chronic thromboembolic pulmonary hypertension	unknown	Microarray	"This study identified hsa_circ_0002062 as a differentially expressed circRNA in CTEPH blood by microarray. Bioinformatic network analysis suggested it may act in a circRNA_miRNA_mRNA axis by regulating hsa-miR-942_5p and downstream target CDK6, implicating cell cycle/proliferation-related pathways in CTEPH."	0.1768
28682884	Medicine	2017	Microarray expression profile of circular RNAs in chronic thromboembolic pulmonary hypertension.	hsa_circ_0022342				chronic thromboembolic pulmonary hypertension	MONDO:0013024	chronic thromboembolic pulmonary hypertension	unknown	Microarray	"This study identified hsa_circ_0022342 as a differentially expressed circRNA in CTEPH blood by microarray. Bioinformatic network analysis suggested a potential circRNA_miRNA_mRNA axis in which hsa_circ_0022342 regulates hsa-miR-940 and downstream target CRKL, linking the circRNA to the ErbB signaling pathway in CTEPH."	0.1768
28710406	Scientific reports	2017	Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-100338/miR-141-3p pathway in hepatitis B-related hepatocellular carcinoma.		hsa_circ_100338	hsa_circ_SNX27	SNX27	hepatocellular carcinoma	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circRNA_100338 is significantly up-regulated in hepatitis B-related HCC tissues and correlates with metastatic features and reduced survival. Mechanistically, it directly binds and sponges miR-141-3p (validated by reporter assays), thereby promoting invasion/metastatic potential in liver cancer cells; a potential downstream involvement of MTSS1 is suggested."	0.7824
28710406	Scientific reports	2017	Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-100338/miR-141-3p pathway in hepatitis B-related hepatocellular carcinoma.		hsa_circRNA_104075	hsa_circ_NUP153	NUP153	hepatocellular carcinoma	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_104075 (host gene NUP153) is significantly up-regulated in HCC tissues versus paired pericancerous tissues and was validated by qRT-PCR, but no downstream mechanism or functional/clinical role was further characterized in this study."	0.4773
28737829	Molecular medicine reports	2017	Expression profile of circular RNAs in human gastric cancer tissues.	hsa_circ_0000026	circRNA_000026	hsa_circ_EIF4G3	EIF4G3	gastric cancer	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0000026 (EIF4G3-derived; also referred to as circRNA-0026/circ_000026) is significantly down-regulated in gastric cancer tissues versus adjacent normal tissues. The study predicts it may function through a circRNA_miRNA_mRNA network (miR-23a/miR-23b/miR-581/miR-146a/miR-450a), potentially influencing transcription-related processes, and suggests it as a diagnostic biomarker candidate."	0.585
28738961	Zhongguo fei ai za zhi = Chinese journal of lung cancer	2017	[Circular RNA CircHIPK3 Promotes NCI-H1299 and NCI-H2170 Cell Proliferation through miR-379 and its Target IGF1].	hsa_circ_0000284	circHIPK3	hsa_circ_HIPK3	HIPK3	non-small cell lung carcinoma	MONDO:0005233	non-small cell lung carcinoma	unknown	RT-qPCR	"In NSCLC cell lines, circHIPK3 promotes cell proliferation. Mechanistically, it functions as a ceRNA that sponges miR-379, thereby relieving repression of IGF1 and increasing IGF1 expression."	0.7435
28761361	OncoTargets and therapy	2017	Circ-104916 is downregulated in gastric cancer and suppresses migration and invasion of gastric cancer cells.		hsa-circ-104916	hsa_circ_NEK6	NEK6	gastric cancer	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"Circ-104916 (circNEK6) is down-regulated in gastric cancer tissues and cell lines. Its overexpression suppresses gastric cancer cell proliferation, migration, and invasion, at least partly by inhibiting EMT and shifting EMT markers (E-cadherin up; N-cadherin/Vimentin/Slug down). Low circ-104916 is associated with more aggressive clinicopathological features, supporting its potential as a GC biomarker and tumor suppressor."	0.6537
28777011	Diabetes & vascular disease research	2017	Hsa-circRNA11783-2 in peripheral blood is correlated with coronary artery disease and type 2 diabetes mellitus.	hsa_circ_0009036				coronary artery disease	MONDO:0005010	coronary artery disorder	unknown	RT-qPCR; Microarray	"hsa_circ_0009036 was selected from microarray screening and tested by RT-qPCR in a second cohort, but it showed no significant expression difference between CAD/T2DM and controls, so no disease association was supported in this study."	0.4032
28777011	Diabetes & vascular disease research	2017	Hsa-circRNA11783-2 in peripheral blood is correlated with coronary artery disease and type 2 diabetes mellitus.	hsa_circ_0054129				coronary artery disease	MONDO:0005010	coronary artery disorder	unknown	RT-qPCR; Microarray	"hsa_circ_0054129 was selected from microarray screening and tested by RT-qPCR in a validation cohort, but it showed no significant expression difference between CAD/T2DM and controls, so no disease association was supported in this study."	0.4032
28777011	Diabetes & vascular disease research	2017	Hsa-circRNA11783-2 in peripheral blood is correlated with coronary artery disease and type 2 diabetes mellitus.	hsa_circ_0009036				type 2 diabetes mellitus	MONDO:0005148	type 2 diabetes mellitus	unknown	RT-qPCR; Microarray	"hsa_circ_0009036 was selected from microarray screening and tested by RT-qPCR in a second cohort, but it showed no significant expression difference between CAD/T2DM and controls, so no disease association was supported in this study."	0.4032
28777011	Diabetes & vascular disease research	2017	Hsa-circRNA11783-2 in peripheral blood is correlated with coronary artery disease and type 2 diabetes mellitus.	hsa_circ_0054129				type 2 diabetes mellitus	MONDO:0005148	type 2 diabetes mellitus	unknown	RT-qPCR; Microarray	"hsa_circ_0054129 was selected from microarray screening and tested by RT-qPCR in a validation cohort, but it showed no significant expression difference between CAD/T2DM and controls, so no disease association was supported in this study."	0.4032
28777011	Diabetes & vascular disease research	2017	Hsa-circRNA11783-2 in peripheral blood is correlated with coronary artery disease and type 2 diabetes mellitus.		hsa-circRNA11806-28			coronary artery disorder	MONDO:0005010	coronary artery disorder	down-regulated	RT-qPCR; Microarray	"hsa-circRNA11806-28 was identified by microarray and validated by RT-qPCR as significantly down-regulated in peripheral blood of both CAD and T2DM patients versus controls, but no specific mechanism was established."	0.3588
28777011	Diabetes & vascular disease research	2017	Hsa-circRNA11783-2 in peripheral blood is correlated with coronary artery disease and type 2 diabetes mellitus.		hsa-circRNA6510-1			coronary artery disorder	MONDO:0005010	coronary artery disorder	down-regulated	RT-qPCR; Microarray	"hsa-circRNA6510-1 was identified by microarray and validated by RT-qPCR as significantly down-regulated in peripheral blood of both CAD and T2DM patients versus controls, but no specific mechanism was established."	0.3588
28777011	Diabetes & vascular disease research	2017	Hsa-circRNA11783-2 in peripheral blood is correlated with coronary artery disease and type 2 diabetes mellitus.		hsa-circRNA11783-2			coronary artery disorder	MONDO:0005010	coronary artery disorder	down-regulated	RT-qPCR; Microarray	"hsa-circRNA11783-2 is significantly down-regulated in peripheral/whole blood of CAD and T2DM patients and shows significant association with both diseases in logistic regression. The study suggests a potential miRNA-sponge role with predicted binding sites for miR-608 and miR-3907, but no definitive biological function was demonstrated."	0.4679
28777011	Diabetes & vascular disease research	2017	Hsa-circRNA11783-2 in peripheral blood is correlated with coronary artery disease and type 2 diabetes mellitus.		hsa-circRNA11806-28			type 2 diabetes mellitus	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RT-qPCR; Microarray	"hsa-circRNA11806-28 was identified by microarray and validated by RT-qPCR as significantly down-regulated in peripheral blood of both CAD and T2DM patients versus controls, but no specific mechanism was established."	0.3588
28777011	Diabetes & vascular disease research	2017	Hsa-circRNA11783-2 in peripheral blood is correlated with coronary artery disease and type 2 diabetes mellitus.		hsa-circRNA6510-1			type 2 diabetes mellitus	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RT-qPCR; Microarray	"hsa-circRNA6510-1 was identified by microarray and validated by RT-qPCR as significantly down-regulated in peripheral blood of both CAD and T2DM patients versus controls, but no specific mechanism was established."	0.3588
28777011	Diabetes & vascular disease research	2017	Hsa-circRNA11783-2 in peripheral blood is correlated with coronary artery disease and type 2 diabetes mellitus.		hsa-circRNA11783-2			type 2 diabetes mellitus	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RT-qPCR; Microarray	"hsa-circRNA11783-2 is significantly down-regulated in peripheral/whole blood of CAD and T2DM patients and shows significant association with both diseases in logistic regression. The study suggests a potential miRNA-sponge role with predicted binding sites for miR-608 and miR-3907, but no definitive biological function was demonstrated."	0.4679
28779016	Circulation. Cardiovascular genetics	2017	Carotid Plaque Rupture Is Accompanied by an Increase in the Ratio of Serum circR-284 to miR-221 Levels.		circR-284			stroke	MONDO:0005098	stroke disorder	up-regulated	RT-qPCR	"In patients with acute carotid plaque rupture-associated ischemic events, serum circR-284 is increased (validated by ddPCR). The study proposes that circR-284 contains a miR-221 binding site and may function as a miR-221 sponge, and shows that the serum circR-284:miR-221 ratio has strong diagnostic performance for identifying recent plaque rupture and stroke."	0.6522
28779132	Scientific reports	2017	Relationships of circular RNA with diabetes and depression.		hsa-circRNA_003251 			type 2 diabetes mellitus	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RT-qPCR; Microarray	"hsa-circRNA_003251 is up-regulated in whole blood of T2DM patients with depression versus T2DM without depression, validated by RT-qPCR. It is proposed to act within a predicted circRNA/miRNA/mRNA network (miRNA sponge/ceRNA) and is linked by KEGG prediction to thyroid hormone, Wnt, ErbB and MAPK signaling pathways."	0.5135
28779132	Scientific reports	2017	Relationships of circular RNA with diabetes and depression.		hsa_circRNA_015115			type 2 diabetes mellitus	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RT-qPCR; Microarray	"hsa-circRNA_015115 is up-regulated in whole blood of T2DM patients with depression versus those without depression, supported by microarray and RT-qPCR. The study proposes a ceRNA/miRNA-sponge role, including competitive binding to hsa-miR-761 within a predicted circRNA/miRNA/mRNA network, potentially linking it to MAPK-related processes."	0.5135
28779132	Scientific reports	2017	Relationships of circular RNA with diabetes and depression.		hsa _circRNA_100918	hsa_circ_PICALM	PICALM	type 2 diabetes mellitus	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RT-qPCR; Microarray	"hsa-circRNA_100918 (linked to host/target gene PICALM) is up-regulated in whole blood of T2DM patients with depression and validated by RT-qPCR. The paper proposes it may act as a miRNA sponge in a predicted circRNA/miRNA/mRNA network and suggests relevance to autophagy-related mechanisms via PICALM, with KEGG implicating thyroid hormone, Wnt, ErbB and MAPK signaling."	0.5135
28779132	Scientific reports	2017	Relationships of circular RNA with diabetes and depression.	hsa_circ_0005019	hsa_circRNA_005019	hsa_circ_CHSY1	CHSY1	type 2 diabetes mellitus	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RT-qPCR; Microarray	"hsa-circRNA_005019 is down-regulated in whole blood of T2DM patients with depression versus T2DM without depression, supported by microarray and RT-qPCR. It is discussed in connection with CHSY1 and is proposed (with the other validated circRNAs) to potentially function as a miRNA sponge within predicted circRNA/miRNA/mRNA regulatory networks."	0.5135
28824721	Theranostics	2017	Silencing Of Circular RNA-ZNF609 Ameliorates Vascular Endothelial Dysfunction.			hsa_circ_ZNF609	ZNF609	diabetic retinopathy	MONDO:0005266	diabetic retinopathy	dysregulated	RT-qPCR	"cZNF609 is dysregulated during vascular dysfunction and modulates endothelial stress responses and angiogenic behavior. Mechanistically, it acts as a cytoplasmic ceRNA that sponges miR-615-5p to de-repress MEF2A, affecting migration, tube formation, and apoptosis, and its silencing reduces retinal vessel loss and pathological angiogenesis in mouse retinopathy models."	0.8437
28831102	Scientific reports	2017	Circular RNAs expression profiles in human gastric cancer.	hsa_circ_0081146		hsa_circ_COL1A2	COL1A2	gastric cancer	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0081146 is up-regulated in gastric cancer tissues compared with paired non-GC tissues, as supported by microarray screening and qRT-PCR validation in 50 paired clinical samples."	0.4773
28831102	Scientific reports	2017	Circular RNAs expression profiles in human gastric cancer.	hsa_circ_0084720		hsa_circ_SULF1	SULF1	gastric cancer	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0084720 is up-regulated in gastric cancer tissues versus paired non-GC tissues, supported by microarray profiling and qRT-PCR validation in clinical samples."	0.4773
28831102	Scientific reports	2017	Circular RNAs expression profiles in human gastric cancer.	hsa_circ_0060108		hsa_circ_FER1L4	FER1L4	gastric cancer	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0060108 is down-regulated in gastric cancer tissues compared with paired non-GC tissues, validated by qRT-PCR following microarray profiling."	0.4773
28831102	Scientific reports	2017	Circular RNAs expression profiles in human gastric cancer.	hsa_circ_0057104		hsa_circ_PDK1	PDK1	gastric cancer	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0057104 is down-regulated in gastric cancer tissues versus paired non-GC tissues, with qRT-PCR validation supporting the microarray result."	0.4773
28831102	Scientific reports	2017	Circular RNAs expression profiles in human gastric cancer.	hsa_circ_0054971		hsa_circ_SLC1A4	SLC1A4	gastric cancer	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0054971 is down-regulated in gastric cancer tissues relative to matched non-cancerous tissues, validated by qRT-PCR consistent with microarray data."	0.4773
28831102	Scientific reports	2017	Circular RNAs expression profiles in human gastric cancer.	hsa_circ_0063561		hsa_circ_ACO2	ACO2	gastric cancer	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0063561 is down-regulated in gastric cancer tissues compared with paired non-GC tissues, confirmed by qRT-PCR consistent with microarray profiling."	0.4773
28831102	Scientific reports	2017	Circular RNAs expression profiles in human gastric cancer.	hsa_circ_0058766		hsa_circ_DGKD	DGKD	gastric cancer	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0058766 is down-regulated in gastric cancer tissues versus matched non-GC tissues, supported by microarray profiling and confirmed by qRT-PCR in clinical samples."	0.4773
28842720	"Journal of molecular medicine (Berlin, Germany)"	2017	A map of human circular RNAs in clinically relevant tissues.		circROBO1	hsa_circ_ROBO1	ROBO1	"adenosine deaminase-deficient, severe combined immunodeficiency "	MONDO:0007064	"severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency"	up-regulated	RT-qPCR; RNA-seq	"circROBO1 is up-regulated in lymphoblastoid cells from ADA-SCID and WAS patients compared with non-affected controls, and its differential expression was experimentally validated. The study positions circROBO1 as a disease-associated circRNA arising from a phenotypically relevant host gene, without defining a specific downstream mechanism."	0.585
28842720	"Journal of molecular medicine (Berlin, Germany)"	2017	A map of human circular RNAs in clinically relevant tissues.		circCDC42BPA	hsa_circ_CDC42BPA	CDC42BPA	"adenosine deaminase-deficient, severe combined immunodeficiency "	MONDO:0007064	"severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency"	up-regulated	RT-qPCR; RNA-seq	circCDC42BPA is up-regulated in ADA-SCID and WAS patient lymphoblastoid cells compared with controls and was validated by RNase R-based RT-qPCR (with junction confirmation by sequencing). The study links this increased circRNA level to a host gene relevant to WAS/ADA-SCID pathogenesis but does not establish a specific downstream regulatory axis.	0.585
28842720	"Journal of molecular medicine (Berlin, Germany)"	2017	A map of human circular RNAs in clinically relevant tissues.		circTNFRSF11A	hsa_circ_TNFRSF11A	TNFRSF11A	"adenosine deaminase-deficient, severe combined immunodeficiency "	MONDO:0007064	"severe combined immunodeficiency, autosomal recessive, T cell-negative, B cell-negative, NK cell-negative, due to adenosine deaminase deficiency"	up-regulated	RT-qPCR; RNA-seq	circTNFRSF11A is up-regulated in ADA-SCID patient lymphoblastoid cells relative to controls and was validated experimentally in the patient cohort. The study highlights it as a circRNA arising from a phenotypically relevant host gene (TNFRSF11A) but does not define a specific regulatory mechanism.	0.585
28893265	Molecular cancer	2017	Circular RNA_LARP4 inhibits cell proliferation and invasion of gastric cancer by sponging miR-424-5p and regulating LATS1 expression.		hsa_circ_101057	hsa_circ_LARP4	LARP4	gastric cancer	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; ISH; Microarray	"circLARP4 is downregulated in gastric cancer and mainly localized in the cytoplasm. It suppresses GC cell proliferation and invasion by sponging miR-424-5p, thereby relieving repression of LATS1 and modulating downstream YAP signaling. High circLARP4 expression predicts longer overall survival and is an independent prognostic factor in GC."	0.8675
28903484	Journal of the National Cancer Institute	2018	Novel Role of FBXW7 Circular RNA in Repressing Glioma Tumorigenesis.	hsa_circ_0001451	novel_circ_022705	hsa_circ_FBXW7	FBXW7	glioblastoma 	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR; RNA-seq	"circ-FBXW7 (hsa_circ_0001451) is down-regulated in glioblastoma/glioma tissues. It encodes the protein FBXW7-185aa, which suppresses glioma cell proliferation and cell-cycle progression by binding USP28, antagonizing USP28-mediated c-Myc stabilization, and facilitating FBXW7alpha-dependent c-Myc degradation; higher circ-FBXW7 is associated with better overall survival."	0.8689
28906455	International journal of molecular sciences	2017	Deep Circular RNA Sequencing Provides Insights into the Mechanism Underlying Grass Carp Reovirus Infection.		cid_circ_0069			grass carp hemorrhagic disease	MONDO:0002243	hemorrhagic disease	dysregulated	RT-qPCR; RNA-seq	"cid_circ_0069 is among circRNAs with infection-associated expression changes in grass carp spleen after GCRV challenge, supported by RNA-seq and RT-qPCR. It is discussed within a predicted circRNA_miRNA_mRNA regulatory network potentially related to immune and hemorrhagic-response processes during GCRV infection."	0.5608
28906455	International journal of molecular sciences	2017	Deep Circular RNA Sequencing Provides Insights into the Mechanism Underlying Grass Carp Reovirus Infection.		cid_circ_4537			grass carp hemorrhagic disease	MONDO:0002243	hemorrhagic disease	dysregulated	RT-qPCR; RNA-seq	"cid_circ_4537 shows infection-associated expression changes in grass carp spleen after GCRV challenge, with expression supported by RNA-seq and validated by RT-qPCR. It is part of the study¡¯s predicted circRNA_miRNA_mRNA network potentially related to immune and hemorrhagic-response processes during GCRV infection."	0.5608
28906455	International journal of molecular sciences	2017	Deep Circular RNA Sequencing Provides Insights into the Mechanism Underlying Grass Carp Reovirus Infection.		cid_circ_3204	cid_circ_HBAC	HBAC	grass carp hemorrhagic disease	MONDO:0002243	hemorrhagic disease	dysregulated	RT-qPCR; RNA-seq	"cid_circ_3204 (host gene HBAC) is a differentially expressed circRNA in grass carp spleen after GCRV infection, with expression supported by RNA-seq and validated by RT-qPCR. It is analyzed as part of a predicted circRNA_miRNA_mRNA network potentially linked to immune responses and hemorrhagic symptoms during infection."	0.5608
28906455	International journal of molecular sciences	2017	Deep Circular RNA Sequencing Provides Insights into the Mechanism Underlying Grass Carp Reovirus Infection.		cid_circ_4726			grass carp hemorrhagic disease	MONDO:0002243	hemorrhagic disease	dysregulated	RT-qPCR; RNA-seq	cid_circ_4726 is a GCRV infection-associated circRNA in grass carp spleen whose expression measurement by RNA-seq was further supported by RT-qPCR validation. The paper places it within a predicted circRNA_miRNA_mRNA network potentially connected to immune responses and hemorrhagic disease manifestations.	0.5608
28906455	International journal of molecular sciences	2017	Deep Circular RNA Sequencing Provides Insights into the Mechanism Underlying Grass Carp Reovirus Infection.		cid_circ_0043			grass carp hemorrhagic disease	MONDO:0002243	hemorrhagic disease	dysregulated	RT-qPCR; RNA-seq	"cid_circ_0043 is among circRNAs whose expression changes after GCRV infection in grass carp spleen, supported by RNA-seq and validated by RT-qPCR. The study frames it as part of a predicted circRNA_miRNA_mRNA network related to immune responses and hemorrhagic disease processes."	0.5608
28906455	International journal of molecular sciences	2017	Deep Circular RNA Sequencing Provides Insights into the Mechanism Underlying Grass Carp Reovirus Infection.		cid_circ_2061			grass carp hemorrhagic disease	MONDO:0002243	hemorrhagic disease	dysregulated	RT-qPCR; RNA-seq	"cid_circ_2061 is a circRNA with altered expression after GCRV infection in grass carp spleen, supported by RNA-seq and validated by RT-qPCR. The work suggests it may contribute to (or reflect) an mRNA_miRNA_circRNA network involved in immune and hemorrhagic disease processes."	0.5608
28906455	International journal of molecular sciences	2017	Deep Circular RNA Sequencing Provides Insights into the Mechanism Underlying Grass Carp Reovirus Infection.		cid_circ_2960			grass carp hemorrhagic disease	MONDO:0002243	hemorrhagic disease	dysregulated	RT-qPCR; RNA-seq	cid_circ_2960 is a GCRV infection-associated circRNA in grass carp spleen; its circular junction was confirmed by Sanger sequencing and its expression pattern was supported by RT-qPCR in addition to RNA-seq. It is included in predicted circRNA_miRNA_mRNA regulatory analyses relevant to immune/hemorrhagic responses during infection.	0.5971
28906455	International journal of molecular sciences	2017	Deep Circular RNA Sequencing Provides Insights into the Mechanism Underlying Grass Carp Reovirus Infection.		cid_circ_3277			grass carp hemorrhagic disease	MONDO:0002243	hemorrhagic disease	dysregulated	RT-qPCR; RNA-seq	"cid_circ_3277 is a circRNA whose expression changes after GCRV infection in grass carp spleen, supported by RNA-seq and validated by RT-qPCR. The study suggests such dysregulated circRNAs may participate in an mRNA_miRNA_circRNA network affecting immune and hemorrhagic responses."	0.5608
28906455	International journal of molecular sciences	2017	Deep Circular RNA Sequencing Provides Insights into the Mechanism Underlying Grass Carp Reovirus Infection.		cid_circ_2040	cid_circ_TMEM187	TMEM187	grass carp hemorrhagic disease	MONDO:0002243	hemorrhagic disease	dysregulated	RNA-seq	"cid_circ_2040 (host gene TMEM187) is differentially expressed after GCRV infection and was predicted (by MiRanda) to bind many miRNAs, suggesting potential miRNA-sponge/ceRNA involvement in infection responses. Its expression change is supported by RNA-seq but not specifically reported as RT-qPCR-validated for this circRNA."	0.31
28938566	Oncotarget	2017	Screening differential circular RNA expression profiles reveals hsa_circ_0004018 is associated with hepatocellular carcinoma.	hsa_circ_0004018	hsa_circ_4018	hsa_circ_SMYD4	SMYD4	hepatocellular carcinoma	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	hsa_circ_0004018 is significantly down-regulated in HCC tissues and HCC cell lines and shows stage-specific decrease from chronic hepatitis to cirrhosis to HCC. The study predicts a ceRNA axis hsa_circ_0004018_miR-30e-5p/miR-626_MYC that may contribute to HCC carcinogenesis/metastasis and supports its diagnostic potential (AUC 0.848).	0.6556
28947970	Oncotarget	2017	Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients.	hsa_circ_0089378		hsa_circ_VAV2	VAV2	coronary artery disease	MONDO:0005010	coronary artery disorder	up-regulated	Microarray	"In CAD patient plasma, hsa_circ_0089378 is up-regulated and is predicted (via miRanda/ceRNA network) to sponge hsa-miR-130a-3p, thereby promoting TRPM3 expression."	0.1768
28947970	Oncotarget	2017	Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients.	hsa_circ_0083357		hsa_circ_CTSB	CTSB	coronary artery disease	MONDO:0005010	coronary artery disorder	up-regulated	Microarray	"In CAD plasma, hsa_circ_0083357 is up-regulated and is included in a predicted hsa-miR-130a-3p/TRPM3 ceRNA network, suggesting it sponges hsa-miR-130a-3p to promote TRPM3 expression."	0.1768
28947970	Oncotarget	2017	Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients.	hsa_circ_0082824		hsa_circ_CUL1	CUL1	coronary artery disease	MONDO:0005010	coronary artery disorder	up-regulated	Microarray	"hsa_circ_0082824 is up-regulated in CAD plasma and was identified bioinformatically as part of a hsa-miR-130a-3p-mediated circRNA_mRNA (TRPM3) ceRNA network, implying a miRNA-sponge role that promotes TRPM3 expression."	0.1768
28947970	Oncotarget	2017	Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients.	hsa_circ_0068942		hsa_circ_ADD1	ADD1	coronary artery disease	MONDO:0005010	coronary artery disorder	up-regulated	Microarray	"hsa_circ_0068942 is up-regulated in CAD plasma and was included in a predicted hsa-miR-130a-3p/TRPM3 ceRNA network, suggesting it promotes TRPM3 expression by sponging hsa-miR-130a-3p."	0.1768
28947970	Oncotarget	2017	Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients.	hsa_circ_0057576		hsa_circ_HECW2	HECW2	coronary artery disease	MONDO:0005010	coronary artery disorder	up-regulated	Microarray	"hsa_circ_0057576 is up-regulated in CAD plasma and was computationally linked to a hsa-miR-130a-3p/TRPM3 ceRNA network, implying a miRNA sponge role that promotes TRPM3 expression."	0.1768
28947970	Oncotarget	2017	Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients.	hsa_circ_0054537		hsa_circ_PSME4	PSME4	coronary artery disease	MONDO:0005010	coronary artery disorder	up-regulated	Microarray	"hsa_circ_0054537 is up-regulated in CAD plasma and is predicted to sponge hsa-miR-130a-3p in a ceRNA network, contributing to increased TRPM3 expression."	0.1768
28947970	Oncotarget	2017	Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients.	hsa_circ_0051172		hsa_circ_AXL	AXL	coronary artery disease	MONDO:0005010	coronary artery disorder	up-regulated	Microarray	"hsa_circ_0051172 is up-regulated in CAD plasma and is predicted to sponge hsa-miR-130a-3p within a ceRNA network, contributing to TRPM3 upregulation."	0.1768
28947970	Oncotarget	2017	Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients.	hsa_circ_0032970		hsa_circ_TC2N	TC2N	coronary artery disease	MONDO:0005010	coronary artery disorder	up-regulated	Microarray	"hsa_circ_0032970 is up-regulated in CAD plasma and is predicted to sponge hsa-miR-130a-3p in a TRPM3-centered ceRNA network, thereby promoting TRPM3 expression."	0.1768
28947970	Oncotarget	2017	Circular RNAs promote TRPM3 expression by inhibiting hsa-miR-130a-3p in coronary artery disease patients.	hsa_circ_0006323		hsa_circ_DPYD	DPYD	coronary artery disease	MONDO:0005010	coronary artery disorder	up-regulated	Microarray	"hsa_circ_0006323 is up-regulated in CAD plasma and was predicted to sponge hsa-miR-130a-3p in a ceRNA network, thereby promoting TRPM3 expression."	0.1768
28971903	Haematologica	2017	Circular RNAs of the nucleophosmin (NPM1) gene in acute myeloid leukemia.	hsa_circ_0075001		hsa_circ_NPM1	NPM1	acute myeloid leukemia	MONDO:0018874	acute myeloid leukemia	dysregulated	RT-qPCR	"This study quantifies hsa_circ_0075001 (circNPM1) in AML and shows wide inter-patient variability that defines molecular subgroups. High hsa_circ_0075001 expression is associated with reduced expression of Toll-like receptor signaling pathway components and a more immature blast phenotype, while a direct mechanistic role (e.g., miRNA interaction) remains speculative."	0.5466
28971903	Haematologica	2017	Circular RNAs of the nucleophosmin (NPM1) gene in acute myeloid leukemia.	hsa_circ_0100163		hsa_circ_FLT3	FLT3	acute myeloid leukemia	MONDO:0018874	acute myeloid leukemia	dysregulated	RNA-seq	"RNA-seq profiling indicates FLT3-derived circRNAs including hsa_circ_0100163 contribute to an AML-associated circRNA signature. The study highlights that circFLT3 correlates with FLT3 mRNA in healthy controls but not in AML, suggesting disease-associated deregulation at the circular RNA level."	0.1768
28971903	Haematologica	2017	Circular RNAs of the nucleophosmin (NPM1) gene in acute myeloid leukemia.	hsa_circ_0100164		hsa_circ_FLT3	FLT3	acute myeloid leukemia	MONDO:0018874	acute myeloid leukemia	dysregulated	RNA-seq	The paper reports that FLT3 circular reads in the RNA-seq dataset map to hsa_circ_0100164 (among other variants) in AML versus healthy hematopoietic cells. No dedicated functional assays are provided for this specific circRNA.	0.1768
28974900	World journal of gastroenterology	2017	Circular RNA hsa_circ_0000745 may serve as a diagnostic marker for gastric cancer.	hsa_circ_0000745	circ_0000745	hsa_circ_SPECC1	SPECC1	gastric cancer	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; RNA-seq	This study reports that hsa_circ_0000745 (host gene SPECC1) is down-regulated in gastric cancer tissues and in plasma from GC patients. Its plasma level shows diagnostic value by ROC analysis and improves when combined with CEA; predicted miRNA-binding suggests a potential miRNA-sponge/ceRNA role but without functional experimental validation.	0.5963
28974900	World journal of gastroenterology	2017	Circular RNA hsa_circ_0000745 may serve as a diagnostic marker for gastric cancer.		chr16:30740286-30740893|+ / Chr16: 30740287-30740893|+	hsa_circ_SRCAP	SRCAP	gastric cancer	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; RNA-seq	"This circRNA (chr16:30740286-30740893|+, host gene SRCAP) was identified by RNA-seq and validated by qRT-PCR as down-regulated in gastric cancer tissues versus paired adjacent non-tumor tissues. Its downstream functional role and clinical utility were not further characterized in this study."	0.5135
28974900	World journal of gastroenterology	2017	Circular RNA hsa_circ_0000745 may serve as a diagnostic marker for gastric cancer.	hsa_circ_0085616	circ_0085616	hsa_circ_ASAP1	ASAP1	gastric cancer	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0085616 (host gene ASAP1) was among three circRNAs selected from RNA-seq data and was validated by qRT-PCR as up-regulated in gastric cancer tissues versus paired adjacent non-tumor tissues. The study did not further investigate its functional mechanism or clinical value.	0.5135
28977896	Oncotarget	2017	Increased circular RNA UBAP2 acts as a sponge of miR-143 to promote osteosarcoma progression.			hsa_circ_UBAP2	UBAP2	osteosarcoma	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"circUBAP2 is up-regulated in osteosarcoma tissues and cell lines and correlates with advanced stage and worse overall survival. Functionally, it promotes tumor growth by inhibiting apoptosis via sponging miR-143 and thereby increasing Bcl-2 expression, with in vitro and xenograft evidence."	0.7816
28983619	Molecular medicine reports	2017	"Circular RNA expression profiles of peripheral blood mononuclear cells in rheumatoid arthritis patients, based on microarray chip technology."	hsa_circ_0004712	hsa_circRNA_104194	hsa_circ_PDE7B	PDE7B	rheumatoid arthritis	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_104194 (hsa_circ_0004712; host gene PDE7B) is up-regulated in PBMCs from rheumatoid arthritis patients versus healthy controls, supported by microarray and RT-qPCR. The study also reports predicted MRE-based interactions with several miRNAs, but does not establish a validated downstream functional mechanism."	0.4032
28983619	Molecular medicine reports	2017	"Circular RNA expression profiles of peripheral blood mononuclear cells in rheumatoid arthritis patients, based on microarray chip technology."	hsa_circ_0083964	hsa_circRNA_104593			rheumatoid arthritis	MONDO:0008383	rheumatoid arthritis	unknown	RT-qPCR; Microarray	"hsa_circRNA_104593 (hsa_circ_0083964) is one of five circRNAs whose differential expression in RA PBMCs was verified by RT-qPCR as consistent with microarray results, but the paper does not specify its direction of change or mechanism."	0.3588
28983619	Molecular medicine reports	2017	"Circular RNA expression profiles of peripheral blood mononuclear cells in rheumatoid arthritis patients, based on microarray chip technology."	hsa_circ_0064996	hsa_circRNA_103334			rheumatoid arthritis	MONDO:0008383	rheumatoid arthritis	unknown	RT-qPCR; Microarray	"hsa_circRNA_103334 (hsa_circ_0064996) is among the circRNAs whose differential expression in RA PBMCs was confirmed by RT-qPCR, but the article does not provide its up/down direction or a validated mechanism."	0.3588
28983619	Molecular medicine reports	2017	"Circular RNA expression profiles of peripheral blood mononuclear cells in rheumatoid arthritis patients, based on microarray chip technology."	hsa_circ_0032683	hsa_circRNA_101407			rheumatoid arthritis	MONDO:0008383	rheumatoid arthritis	unknown	RT-qPCR; Microarray	"hsa_circRNA_101407 (hsa_circ_0032683) shows differential expression in RA PBMCs that was validated by RT-qPCR as consistent with microarray data, but no direction or mechanism is specified for this circRNA in the provided text."	0.3588
28983619	Molecular medicine reports	2017	"Circular RNA expression profiles of peripheral blood mononuclear cells in rheumatoid arthritis patients, based on microarray chip technology."	hsa_circ_0052012	hsa_circRNA_102594			rheumatoid arthritis	MONDO:0008383	rheumatoid arthritis	unknown	RT-qPCR; Microarray	"hsa_circRNA_102594 (hsa_circ_0052012) is differentially expressed in RA PBMCs and its microarray finding was confirmed by RT-qPCR, but the direction of change and specific mechanism are not reported in the provided text."	0.3588
29018509	Oxidative medicine and cellular longevity	2017	circRNA_0046367 Prevents Hepatoxicity of Lipid Peroxidation: An Inhibitory Role against Hepatic Steatosis.	hsa_circ_0046367				hepatic steatosis	MONDO:0100430	fibrotic liver disease	down-regulated	RT-qPCR	"circRNA_0046367 is down-regulated in hepatic steatosis (NAFLD patient liver tissue and FFA-induced HepG2 model). It functions as a miR-34a sponge to relieve miR-34a-mediated repression of PPARalpha, restoring lipid-metabolism genes (e.g., CPT2, ACBD3), reducing triglyceride accumulation and lipid peroxidation, improving mitochondrial function, promoting proliferation, and inhibiting apoptosis."	0.6952
29037220	Journal of experimental & clinical cancer research : CR	2017	circGFRA1 and GFRA1 act as ceRNAs in triple negative breast cancer by regulating miR-34a.		hsa_circ_005239	hsa_circ_GFRA1	GFRA1	triple negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; Microarray	"circGFRA1 (hsa_circ_005239), derived from GFRA1, is up-regulated in TNBC and mainly localized in the cytoplasm. It promotes TNBC cell proliferation and inhibits apoptosis, and enhances tumor growth in xenografts. Mechanistically, circGFRA1 acts as a ceRNA by sponging miR-34a to derepress GFRA1, and high circGFRA1 is associated with poorer OS/DFS."	0.8069
29039473	International journal of molecular medicine	2017	Altered expression profiles of circular RNA in colorectal cancer tissues from patients with lung metastasis.		hsa_circRNA_105055			colorectal cancer	MONDO:0005575	colorectal cancer	up-regulated	Microarray	"hsa_circRNA_105055 was up-regulated in CRC tissues from patients with lung metastasis versus non-metastatic CRC tissues. Bioinformatics prediction suggested it may sponge miR-7 and thereby affect PRKCB, potentially linking to NF-kappaB or Wnt signaling in pulmonary metastasis."	0.4685
29039473	International journal of molecular medicine	2017	Altered expression profiles of circular RNA in colorectal cancer tissues from patients with lung metastasis.		hsa_circRNA_086376			colorectal cancer	MONDO:0005575	colorectal cancer	down-regulated	Microarray	"hsa_circRNA_086376 was down-regulated in CRC tissues from patients with lung metastasis versus non-metastatic CRC tissues. It was bioinformatically predicted to bind miR-7 and participate in a metastasis-related regulatory network (e.g., involving EPHA3/PRKCB and NF-kappaB or Wnt signaling), but the interaction was not experimentally validated."	0.4685
29039473	International journal of molecular medicine	2017	Altered expression profiles of circular RNA in colorectal cancer tissues from patients with lung metastasis.		hsa_circRNA_102761			colorectal cancer	MONDO:0005575	colorectal cancer	down-regulated	Microarray	"hsa_circRNA_102761 was down-regulated in CRC tissues from patients with lung metastasis versus non-metastatic CRC tissues. It was predicted to bind miR-7 and relate to miR-7 target genes (including BRCA1 and ABCC1), forming a putative ceRNA network implicated in pulmonary metastasis."	0.4685
29039473	International journal of molecular medicine	2017	Altered expression profiles of circular RNA in colorectal cancer tissues from patients with lung metastasis.		hsa_circRNA_102348			colorectal cancer	MONDO:0005575	colorectal cancer	unknown	Microarray	"hsa_circRNA_102348 was identified in the microarray screen and predicted (bioinformatically) to bind miR-410, with PDHX listed as a miR-410 target gene. Its direction of differential expression and functional impact on CRC lung metastasis were not specified."	0.4685
29039473	International journal of molecular medicine	2017	Altered expression profiles of circular RNA in colorectal cancer tissues from patients with lung metastasis.		hsa_circRNA_102562			colorectal cancer	MONDO:0005575	colorectal cancer	unknown	Microarray	"hsa_circRNA_102562 was identified in the microarray screen and predicted (bioinformatically) to bind miR-410, with ATM and ABCC1 listed as miR-410 target genes. Its differential-expression direction and functional impact on CRC lung metastasis were not specified."	0.4685
29095957	PloS one	2017	Circular RNA profile of infantile hemangioma by microarray analysis.		hsa_circRNA_100933 / circRNA_100933 	hsa_circ_NOX4	NOX4	hemangioma	MONDO:0006500	hemangioma	up-regulated	RT-qPCR; Microarray	hsa_circRNA_100933 is up-regulated in infantile hemangioma tissues and was validated by qRT-PCR. Bioinformatics prediction supports a circRNA-miRNA-mRNA regulatory network (with miR-1298-3p/miR-892b/miR-2113/miR-137/miR-514a-5p) potentially related to angiogenesis and vascular development processes.	0.585
29095957	PloS one	2017	Circular RNA profile of infantile hemangioma by microarray analysis.		hsa_circRNA_100709 / circRNA_100709	hsa_circ_FAM53B	FAM53B	hemangioma	MONDO:0006500	hemangioma	up-regulated	RT-qPCR; Microarray	hsa_circRNA_100709 is up-regulated in infantile hemangioma tissues and its increased expression was confirmed by qRT-PCR. The study did not further characterize its downstream miRNA/mRNA network or functional effects.	0.5541
29095957	PloS one	2017	Circular RNA profile of infantile hemangioma by microarray analysis.		hsa_circRNA_104310 / circRNA_104310	hsa_circ_ZDHHC4	ZDHHC4	hemangioma	MONDO:0006500	hemangioma	down-regulated	RT-qPCR; Microarray	hsa_circRNA_104310 is down-regulated in infantile hemangioma tissues and was validated by qRT-PCR. A predicted circRNA-miRNA-mRNA network (including miR-499a-3p/miR-1271-3p/miR-216a-3p/miR-197-3p/miR-489-3p) links it to target genes enriched in HIF-1/angiogenesis-related pathways.	0.585
29109781	Theranostics	2017	A Circular RNA Binds To and Activates AKT Phosphorylation and Nuclear Localization Reducing Apoptosis and Enhancing Cardiac Repair.		circ-Amotl1	hsa_circ_Amotl1	Amotl1	Doxorubicin (Dox)-induced cardiomyopathy	MONDO:0023006	doxorubicin induced cardiomyopathy	unknown	RT-qPCR; Northern Blot; ISH; Microarray	"circ-Amotl1 physically binds PDK1 and AKT1 to promote AKT phosphorylation and nuclear translocation of pAKT, thereby enhancing cell proliferation/survival and reducing apoptosis. In vivo delivery of circ-Amotl1 alleviates doxorubicin-induced cardiomyopathy and adverse remodeling in mice, supporting a cardioprotective/therapeutic role."	0.7451
29123417	OncoTargets and therapy	2017	The expression profile and clinical significance of circRNA0003906 in colorectal cancer.	hsa_circ_0003906				colorectal cancer	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"circRNA0003906 is significantly down-regulated in colorectal cancer tissues and most CRC cell lines. Its low expression is associated with poor differentiation and lymphatic metastasis, and it shows diagnostic potential (AUC 0.818) for distinguishing CRC tissues from healthy controls."	0.6238
29144509	Cell death & disease	2017	Circular RNA expression is suppressed by androgen receptor (AR)-regulated adenosine deaminase that acts on RNA (ADAR1) in human hepatocellular carcinoma.	hsa_circ_0085154		hsa_circ_PABPC1	PABPC1	hepatocellular carcinoma	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"CircARSP91 (hsa_circ_0085154), a PABPC1-derived circRNA, is suppressed by the AR/ADAR1 pathway in HCC. Functionally, CircARSP91 inhibits HCC cell proliferation and tumor growth in vitro and in an orthotopic mouse model, but its downstream molecular mechanism is not yet defined."	0.5627
29151929	Journal of Cancer	2017	Identification of circular RNA signature in bladder cancer.	hsa_circ_0091017				bladder cancer	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0091017 is significantly down-regulated in bladder cancer tissues compared with adjacent non-cancerous tissues, confirmed by RNA-seq and RT-qPCR in an independent cohort. The authors suggest dysregulated circRNAs like this one may be implicated in BCa tumorigenesis and have diagnostic potential, but no specific mechanism was established."	0.5909
29151929	Journal of Cancer	2017	Identification of circular RNA signature in bladder cancer.	hsa_circ_0002024				bladder cancer	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0002024 is significantly down-regulated in bladder cancer tissues compared with adjacent non-cancerous tissues, confirmed by RNA-seq and RT-qPCR in an independent cohort. The study does not provide a specific downstream mechanism for this circRNA but proposes dysregulated circRNAs as potential diagnostic markers in BCa."	0.5909
29156822	Oncotarget	2017	Circular RNA expression profiles reveal that hsa_circ_0018289 is up-regulated in cervical cancer and promotes the tumorigenesis.	hsa_circ_0018289				cervical cancer	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0018289 is up-regulated in cervical cancer tissues and cell lines. Its knockdown suppresses cervical cancer cell proliferation, migration, invasion, and xenograft tumor growth, and it directly binds miR-497, consistent with a miRNA-sponge role."	0.721
29207676	Oncotarget	2017	Circular RNA hsa_circ_000984 promotes colon cancer growth and metastasis by sponging miR-106b.	hsa_circ_0001724	hsa_circ_000984	hsa_circ_CDK6	CDK6	colorectal cancer	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"hsa_circ_000984 is up-regulated in colorectal cancer tissues and cell lines and is associated with advanced TNM stage. It promotes CRC proliferation, cell-cycle progression, migration/invasion and xenograft tumor growth by sponging miR-106b and increasing CDK6 expression via a ceRNA mechanism."	0.7181
29221160	Oncotarget	2017	Circular RNA profile indicates circular RNA VRK1 is negatively related with breast cancer stem cells.			hsa_circ_VRK1	VRK1	breast cancer	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; RNA-seq	"circVRK1 is down-regulated in breast cancer stem cell-enriched mammospheres versus non-BCSCs. Functionally, circVRK1 suppresses BCSC self-renewal/expansion; its knockdown increases mammosphere/colony formation and stemness markers. Mechanistically, it is predicted to interact with mir-153-5p, suggesting a potential ceRNA-like inhibitory axis on stemness."	0.6212
29221160	Oncotarget	2017	Circular RNA profile indicates circular RNA VRK1 is negatively related with breast cancer stem cells.		circBRIP	hsa_circ_BRIP1	BRIP1	breast cancer	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; RNA-seq	circBRIP is among six circRNAs validated by RT-qPCR and is down-regulated in mammosphere-derived BCSCs versus adherent non-BCSCs. No specific functional mechanism for circBRIP was experimentally characterized beyond expression profiling.	0.437
29221160	Oncotarget	2017	Circular RNA profile indicates circular RNA VRK1 is negatively related with breast cancer stem cells.		circOLA	hsa_circ_OLA1	OLA1	breast cancer	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; RNA-seq	circOLA is down-regulated in mammosphere-derived BCSCs and its decreased expression was validated by RT-qPCR. The study did not experimentally define a specific downstream mechanism for circOLA.	0.437
29221160	Oncotarget	2017	Circular RNA profile indicates circular RNA VRK1 is negatively related with breast cancer stem cells.		circETFA	hsa_circ_ETFA	ETFA	breast cancer	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; RNA-seq	"circETFA is down-regulated in mammosphere-derived BCSCs and was validated by RT-qPCR, but no specific function or mechanism was characterized in this study."	0.437
29221160	Oncotarget	2017	Circular RNA profile indicates circular RNA VRK1 is negatively related with breast cancer stem cells.		circMED13	hsa_circ_MED13	MED13	breast cancer	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; RNA-seq	circMED13 is down-regulated in mammosphere-derived BCSCs and was validated by RT-qPCR; no direct functional assays were reported for circMED13 in this study.	0.437
29221160	Oncotarget	2017	Circular RNA profile indicates circular RNA VRK1 is negatively related with breast cancer stem cells.		circBCL11B	hsa_circ_BCL11B	BCL11B	breast cancer	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; RNA-seq	circBCL11B is down-regulated in mammosphere-derived BCSCs and validated by RT-qPCR; the paper does not provide circBCL11B-specific mechanistic or functional experiments.	0.437
29228714	Oncotarget	2017	Unique expression signatures of circular RNAs in response to DNA tumor virus SV40 infection.		circRNA1273			Simian virus 40 infection	MONDO:0025102	monkey disease	unknown	RT-qPCR; RNA-seq	circRNA1273 was one of seven circRNAs selected from annotations whose back-splice junction was experimentally confirmed in Vero cells using RT-PCR after RNase R treatment and validated by Sanger sequencing in the context of SV40 infection transcriptome profiling.	0.4835
29228714	Oncotarget	2017	Unique expression signatures of circular RNAs in response to DNA tumor virus SV40 infection.		circRNA1040			Simian virus 40 infection	MONDO:0025102	monkey disease	unknown	RT-qPCR; RNA-seq	"circRNA1040 was experimentally validated as a circular RNA in Vero cells (RNase R resistant; divergent RT-PCR; Sanger-confirmed junction) within the SV40 infection circRNA transcriptome study, but its specific differential-expression direction was not reported in the provided text."	0.4835
29228714	Oncotarget	2017	Unique expression signatures of circular RNAs in response to DNA tumor virus SV40 infection.		circRNA1005			Simian virus 40 infection	MONDO:0025102	monkey disease	unknown	RT-qPCR; RNA-seq	"circRNA1005 was among the selected circRNAs whose circular junction was validated (RNase R resistance, divergent RT-PCR, Sanger sequencing) in SV40-infected/uninfected Vero cells, supporting reliability of the circRNA RNA-seq identification pipeline."	0.4835
29228714	Oncotarget	2017	Unique expression signatures of circular RNAs in response to DNA tumor virus SV40 infection.		circRNA1013			Simian virus 40 infection	MONDO:0025102	monkey disease	unknown	RT-qPCR; RNA-seq	circRNA1013 was validated as a bona fide circRNA (RT-PCR with divergent primers after RNase R treatment and Sanger sequencing of the back-splice junction) in the SV40-infected Vero cell circRNA profiling study.	0.4835
29228714	Oncotarget	2017	Unique expression signatures of circular RNAs in response to DNA tumor virus SV40 infection.		circRNA1220			Simian virus 40 infection	MONDO:0025102	monkey disease	unknown	RT-qPCR; RNA-seq	"circRNA1220 was one of the circRNAs experimentally confirmed to be circular (RNase R resistant, divergent RT-PCR positive, junction validated by Sanger sequencing) in the SV40 infection circRNA profiling of Vero cells."	0.4835
29228714	Oncotarget	2017	Unique expression signatures of circular RNAs in response to DNA tumor virus SV40 infection.		circRNA1195			Simian virus 40 infection	MONDO:0025102	monkey disease	unknown	RT-qPCR; RNA-seq	"circRNA1195 was included among circRNAs whose back-splice junctions were experimentally validated, supporting that the circRNA candidates detected by RNA-seq were reliable in SV40-infected Vero cells."	0.4835
29228714	Oncotarget	2017	Unique expression signatures of circular RNAs in response to DNA tumor virus SV40 infection.		circRNA1088			Simian virus 40 infection	MONDO:0025102	monkey disease	unknown	RT-qPCR; RNA-seq	"circRNA1088 was experimentally validated as a circular RNA in Vero cells (divergent RT-PCR, RNase R resistance, and Sanger sequencing of junction) within the context of SV40 infection-associated circRNA transcriptome profiling."	0.4835
29228714	Oncotarget	2017	Unique expression signatures of circular RNAs in response to DNA tumor virus SV40 infection.		circRNA2389			Simian virus 40 infection	MONDO:0025102	monkey disease	unknown	RNA-seq	"In SV40-infected Vero cells, circRNA2389 was predicted in an integrated network to act as a miRNA decoy for cellular miRNA NC_023666.1_29685, thereby indirectly regulating SYT10 (XM_007968135.1) as part of a circRNA_miRNA_mRNA circuit."	0.1768
29228714	Oncotarget	2017	Unique expression signatures of circular RNAs in response to DNA tumor virus SV40 infection.		circRNA10160			Simian virus 40 infection	MONDO:0025102	monkey disease	unknown	RNA-seq	circRNA10160 was predicted to form a ceRNA circuit in SV40 infection by competitively binding miRNA NC_023666.1_29685 and indirectly regulating SYT10 (XM_007968135.1).	0.1768
29228714	Oncotarget	2017	Unique expression signatures of circular RNAs in response to DNA tumor virus SV40 infection.		circRNA9302			Simian virus 40 infection	MONDO:0025102	monkey disease	unknown	RNA-seq	circRNA9302 was predicted to act as a miRNA decoy for NC_023666.1_29685 and thereby indirectly regulate SYT10 during SV40 infection in Vero cells.	0.1768
29228714	Oncotarget	2017	Unique expression signatures of circular RNAs in response to DNA tumor virus SV40 infection.		circRNA9841			Simian virus 40 infection	MONDO:0025102	monkey disease	unknown	RNA-seq	"circRNA9841 was computationally implicated in a circRNA_miRNA_mRNA regulatory circuit during SV40 infection, potentially sponging NC_023666.1_29685 to indirectly regulate SYT10 expression."	0.1768
29228714	Oncotarget	2017	Unique expression signatures of circular RNAs in response to DNA tumor virus SV40 infection.		circRNA9157			Simian virus 40 infection	MONDO:0025102	monkey disease	unknown	RNA-seq	circRNA9157 was predicted to participate in a ceRNA-like circuit in SV40 infection by competitively binding cellular miRNA NC_023666.1_29685 and indirectly regulating SYT10.	0.1768
29228714	Oncotarget	2017	Unique expression signatures of circular RNAs in response to DNA tumor virus SV40 infection.		circRNA1856			Simian virus 40 infection	MONDO:0025102	monkey disease	unknown	RNA-seq	circRNA1856 was predicted to sponge cellular miRNA NC_023658.1_20825 and thereby indirectly regulate CNOT4 (XM_007983021.1) during SV40 infection in Vero cells.	0.1768
29228714	Oncotarget	2017	Unique expression signatures of circular RNAs in response to DNA tumor virus SV40 infection.		circRNA2190			Simian virus 40 infection	MONDO:0025102	monkey disease	unknown	RNA-seq	circRNA2190 was predicted to competitively bind cellular miRNA NC_023658.1_20825 and indirectly regulate CNOT4 as part of an SV40 infection-related circRNA_miRNA_mRNA circuit.	0.1768
29228714	Oncotarget	2017	Unique expression signatures of circular RNAs in response to DNA tumor virus SV40 infection.		circRNA5444			Simian virus 40 infection	MONDO:0025102	monkey disease	unknown	RNA-seq	"circRNA5444 was predicted to function as a ceRNA/miRNA sponge for NC_023658.1_20825, indirectly regulating CNOT4 during SV40 infection."	0.1768
29228714	Oncotarget	2017	Unique expression signatures of circular RNAs in response to DNA tumor virus SV40 infection.		circRNA9500			Simian virus 40 infection	MONDO:0025102	monkey disease	unknown	RNA-seq	circRNA9500 was predicted to participate in SV40 infection-related ceRNA circuits by sharing/binding cellular miRNA NC_023658.1_20825 and indirectly regulating CNOT4 and MED13L transcripts.	0.1768
29228714	Oncotarget	2017	Unique expression signatures of circular RNAs in response to DNA tumor virus SV40 infection.		circRNA9652			Simian virus 40 infection	MONDO:0025102	monkey disease	unknown	RNA-seq	circRNA9652 was predicted to share/bind cellular miRNA NC_023658.1_20825 and indirectly regulate CNOT4 and MED13L during SV40 infection (a ceRNA-like regulatory circuit).	0.1768
29228714	Oncotarget	2017	Unique expression signatures of circular RNAs in response to DNA tumor virus SV40 infection.		circRNA9915			Simian virus 40 infection	MONDO:0025102	monkey disease	unknown	RNA-seq	circRNA9915 was predicted to participate in SV40 infection-related ceRNA regulation by binding/shared miRNA NC_023658.1_20825 and indirectly regulating CNOT4 and MED13L.	0.1768
29228714	Oncotarget	2017	Unique expression signatures of circular RNAs in response to DNA tumor virus SV40 infection.		circRNA9993			Simian virus 40 infection	MONDO:0025102	monkey disease	unknown	RNA-seq	circRNA9993 was predicted to be involved in SV40 infection-related ceRNA regulation by sharing/binding miRNA NC_023658.1_20825 and indirectly regulating CNOT4 and MED13L transcripts.	0.1768
29228714	Oncotarget	2017	Unique expression signatures of circular RNAs in response to DNA tumor virus SV40 infection.		circRNA10078			Simian virus 40 infection	MONDO:0025102	monkey disease	unknown	RNA-seq	"circRNA10078 was predicted to share miRNA NC_023658.1_20825 with MED13L (XM_008004842.1), indirectly regulating MED13L as part of an SV40 infection-related circRNA_miRNA_mRNA circuit."	0.1768
29228714	Oncotarget	2017	Unique expression signatures of circular RNAs in response to DNA tumor virus SV40 infection.		circRNA1791			Simian virus 40 infection	MONDO:0025102	monkey disease	unknown	RNA-seq	circRNA1791 was predicted to participate in SV40 infection-related ceRNA regulation by sharing miRNA NC_023658.1_20825 and indirectly regulating MED13L.	0.1768
29228714	Oncotarget	2017	Unique expression signatures of circular RNAs in response to DNA tumor virus SV40 infection.		circRNA8830			Simian virus 40 infection	MONDO:0025102	monkey disease	unknown	RNA-seq	circRNA8830 was predicted to share miRNA NC_023658.1_20825 and indirectly regulate MED13L in SV40-infected Vero cells via a ceRNA-like mechanism.	0.1768
29245971	Oncotarget	2017	Systematic analysis of the expression profile of non-coding RNAs involved in ischemia/reperfusion-induced acute kidney injury in mice using RNA sequencing.	mmu_circ_0006082				acute kidney injury	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR; RNA-seq	mmu_circ_0006082 is up-regulated in mouse kidneys after ischemia/reperfusion-induced AKI and was validated by RT-qPCR consistent with RNA-seq. The study did not define a specific downstream mechanism or function for this circRNA beyond differential expression profiling.	0.4625
29245971	Oncotarget	2017	Systematic analysis of the expression profile of non-coding RNAs involved in ischemia/reperfusion-induced acute kidney injury in mice using RNA sequencing.	mmu_circ_0008801				acute kidney injury	MONDO:0002492	acute kidney injury	down-regulated	RT-qPCR; RNA-seq	mmu_circ_0008801 is down-regulated in mouse kidneys after ischemia/reperfusion-induced AKI and was included among circRNAs validated by RT-qPCR consistent with RNA-seq. No specific functional mechanism for mmu_circ_0008801 was experimentally established in this study.	0.4625
29245971	Oncotarget	2017	Systematic analysis of the expression profile of non-coding RNAs involved in ischemia/reperfusion-induced acute kidney injury in mice using RNA sequencing.	mmu_circ_0004646				acute kidney injury	MONDO:0002492	acute kidney injury	up-regulated	RNA-seq	"mmu_circ_0004646 is up-regulated in mouse kidneys after IR-induced AKI (RNA-seq). The study experimentally validated that mmu_circ_0004646 can sponge mmu-miR-874-3p using a dual-luciferase reporter assay, supporting its involvement in a ceRNA-like interaction context related to apoptosis-associated regulation."	0.5079
29248507	EBioMedicine	2018	Potential Diagnostic Power of Blood Circular RNA Expression in Active Pulmonary Tuberculosis.	hsa_circ_0000681		hsa_circ_PRKCB	PRKCB	tuberculosis	MONDO:0018076	tuberculosis	up-regulated	RT-qPCR; RNA-seq; Microarray	hsa_circ_0000681 (host gene PRKCB) is up-regulated in PBMCs from active pulmonary TB patients and is part of a 7-circRNA PBMC signature that can differentiate TB patients from healthy controls with high diagnostic accuracy (AUC 0.946).	0.6142
29248507	EBioMedicine	2018	Potential Diagnostic Power of Blood Circular RNA Expression in Active Pulmonary Tuberculosis.	hsa_circ_0002113		hsa_circ_IFNGR2	IFNGR2	tuberculosis	MONDO:0018076	tuberculosis	up-regulated	RT-qPCR; RNA-seq; Microarray	hsa_circ_0002113 (host gene IFNGR2) is up-regulated in PBMCs from active pulmonary TB patients and contributes to a 7-circRNA PBMC diagnostic signature with AUC 0.946 distinguishing TB from healthy controls.	0.6142
29248507	EBioMedicine	2018	Potential Diagnostic Power of Blood Circular RNA Expression in Active Pulmonary Tuberculosis.	hsa_circ_0002362		hsa_circ_ASAP2	ASAP2	tuberculosis	MONDO:0018076	tuberculosis	up-regulated	RT-qPCR; RNA-seq; Microarray	hsa_circ_0002362 (host gene ASAP2) is up-regulated in PBMCs from active pulmonary TB patients and is part of a 7-circRNA PBMC diagnostic signature validated by qRT-PCR and ROC analysis (AUC 0.946).	0.6142
29248507	EBioMedicine	2018	Potential Diagnostic Power of Blood Circular RNA Expression in Active Pulmonary Tuberculosis.	hsa_circ_0002908		hsa_circ_PTK2	PTK2	tuberculosis	MONDO:0018076	tuberculosis	up-regulated	RT-qPCR; RNA-seq; Microarray	hsa_circ_0002908 (host gene PTK2) is up-regulated in PBMCs from active pulmonary TB patients and is part of a 7-circRNA PBMC diagnostic signature validated in an independent cohort (AUC 0.946).	0.6142
29248507	EBioMedicine	2018	Potential Diagnostic Power of Blood Circular RNA Expression in Active Pulmonary Tuberculosis.	hsa_circ_0008797		hsa_circ_GSK3B	GSK3B	tuberculosis	MONDO:0018076	tuberculosis	up-regulated	RT-qPCR; RNA-seq; Microarray	hsa_circ_0008797 (host gene GSK3B) is up-regulated in PBMCs from active pulmonary TB patients and is included in a validated 7-circRNA PBMC diagnostic signature (AUC 0.946).	0.6142
29248507	EBioMedicine	2018	Potential Diagnostic Power of Blood Circular RNA Expression in Active Pulmonary Tuberculosis.	hsa_circ_0063179		hsa_circ_CSF2RB	CSF2RB	tuberculosis	MONDO:0018076	tuberculosis	up-regulated	RT-qPCR; RNA-seq; Microarray	hsa_circ_0063179 (host gene CSF2RB) is up-regulated in PBMCs from active pulmonary TB patients and forms part of a validated 7-circRNA PBMC signature that distinguishes TB from healthy controls (AUC 0.946).	0.6142
29251325	International journal of molecular medicine	2018	"CD90 promotes cell migration, viability and sphere_forming ability of hepatocellular carcinoma cells."	hsa_circ_0067531		hsa_circ_PIK3CB	PIK3CB	hepatocellular carcinoma	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0067531 is down-regulated in HCC tissues versus adjacent normal tissues and is implicated (but not functionally verified) in CD90-related malignant phenotypes potentially via the PI3K/AKT pathway, suggesting diagnostic/therapeutic relevance."	0.5909
29255366	OncoTargets and therapy	2017	CircRNA_100782 regulates pancreatic carcinoma proliferation through the IL6-STAT3 pathway.		circRNA_100782			pancreatic ductal adenocarcinoma	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circRNA_100782 is upregulated in PDAC and promotes pancreatic cancer cell proliferation. Mechanistically, it sponges miR-124 to relieve repression of IL6R and STAT3, activating the IL6-JAK2-STAT3 pathway and supporting tumor growth in a BxPC3 xenograft model."	0.6996
29262850	Genome biology	2017	The oncogenic role of circPVT1 in head and neck squamous cell carcinoma is mediated through the mutant p53/YAP/TEAD transcription-competent complex.		circPVT1 / circ6	hsa_circ_PVT1	PVT1	head and neck squamous cell carcinoma	MONDO:0010150	head and neck squamous cell carcinoma	up-regulated	RT-qPCR	"In HNSCC, circPVT1 is up-regulated (especially in TP53-mutant tumors) and promotes malignant phenotypes such as proliferation and colony formation, and contributes to cisplatin resistance. Mechanistically, it is transcriptionally activated by the mut-p53/YAP/TEAD complex, binds YAP (supporting an autoregulatory loop), and represses miR-497-5p to increase proliferation-associated genes (e.g., aurka, mki67, bub1). High circPVT1 expression is associated with poorer overall survival."	0.8267
29263845	NPJ genomic medicine	2017	Circular RNA expression is abundant and correlated to aggressiveness in early-stage bladder cancer.		circHIPK3	hsa_circ_HIPK3	HIPK3	bladder cancer	MONDO:0004986	urinary bladder carcinoma	up-regulated	RNA-seq	"circHIPK3 is upregulated in the less aggressive NMIBC risk class and higher expression predicts a lower risk of progression independently of the linear transcript and host gene. It is mainly localized in the cytoplasm and shows enrichment of miRNA target sites/SCEs, but the study does not support a strong single-miRNA sponge mechanism."	0.63
29263845	NPJ genomic medicine	2017	Circular RNA expression is abundant and correlated to aggressiveness in early-stage bladder cancer.		circCDYL	hsa_circ_CDYL	CDYL	bladder cancer	MONDO:0004986	urinary bladder carcinoma	up-regulated	RNA-seq	"circCDYL is upregulated in the less aggressive NMIBC risk class and higher expression predicts a lower risk of progression independently of the linear transcript and host gene. It is mainly localized in the cytoplasm (detected in FL3 and T24 fractions), and the study reports no enrichment of SCEs or conserved miRNA binding sites for circCDYL."	0.4679
29277177	Zhongguo fei ai za zhi = Chinese journal of lung cancer	2017	[Effect of Circular RNA UBAP2 Silencing on Proliferation and Invasion of Human Lung Cancer A549 Cells and Its Mechanism].			hsa_circ_UBAP2	UBAP2	lung adenocarcinoma	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"circUBAP2 is up-regulated in lung adenocarcinoma tissues and functions as a pro-tumor circRNA in A549 cells. Silencing circUBAP2 suppresses proliferation and invasion, induces G0/G1 arrest and anoikis/apoptosis, and is linked to reduced JNK/ERK1/2 activity. Mechanistically, circUBAP2 directly binds miR-339-5p, miR-96-3p and miR-135b-3p and affects UBAP2 reporter activity, suggesting a ceRNA-like regulatory role."	0.6278
29280973	International journal of molecular sciences	2017	Transcriptome-Wide Identification and Characterization of Potato Circular RNAs in Response to Pectobacterium carotovorum Subspecies brasiliense Infection.		chr02:43604462|43622094			Pectobacterium carotovorum subsp. brasiliense (Pcb) infection 	Plant diseases		unknown	RNA-seq	"This study highlighted circRNA chr02:43604462|43622094 as a hub in a co-expression subnetwork during potato response to Pcb infection, connected to defense-related coding genes (RLKs, TFs, PRR) and lincRNAs. Its role was inferred from network association rather than direct functional experiments."	0.1768
29286141	Oncology reports	2018	CircDOCK1 suppresses cell apoptosis via inhibition of miR_196a_5p by targeting BIRC3 in OSCC.		hsa_circ_100721	hsa_circ_DOCK1	DOCK1	oral cavity squamous cell carcinoma	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"circDOCK1 is up-regulated in OSCC tissues and cell lines and acts as an anti-apoptotic circRNA. It functions as a ceRNA to sponge miR-196a-5p, thereby increasing BIRC3 expression and suppressing OSCC cell apoptosis, suggesting biomarker/therapeutic potential."	0.7399
29290828	Theranostics	2018	circRNA Mediates Silica-Induced Macrophage Activation Via HECTD1/ZC3H12A-Dependent Ubiquitination.	mmu_circ_0000375	mm9_circ_002888	mmu_circ_HECTD1	HECTD1	silicosis	MONDO:0005960	silicosis	down-regulated	RT-qPCR; Microarray	"In SiO2-induced silicosis models, circHECTD1 is down-regulated in macrophages and counteracts macrophage activation and reduced viability. Mechanistically, it interacts with ZC3H12A and is linked to regulation of its host gene HECTD1 protein/ubiquitination signaling, influencing macrophage-driven fibroblast activation and migration."	0.7302
29291016	Oncotarget	2017	Circular RNA hsa_circ_0021001 in peripheral blood: a potential novel biomarker in the screening of intracranial aneurysm.	hsa_circ_0021001		hsa_circ_ARFIP2	ARFIP2	intracranial aneurysms 	MONDO:0005291	brain aneurysm	down-regulated	RT-qPCR	"hsa_circ_0021001 is significantly down-regulated in peripheral blood from intracranial aneurysm patients versus healthy controls. It shows good diagnostic performance (ROC AUC 0.87) and higher expression is associated with longer DFS and OS, supporting its potential as a diagnostic/prognostic biomarker for IA."	0.6518
29307994	World journal of gastroenterology	2017	Circular RNA circ-LDLRAD3 as a biomarker in diagnosis of pancreatic cancer.	hsa_circ_0006988		hsa_circ_LDLRAD3	LDLRAD3	pancreatic cancer	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"circ-LDLRAD3 (hsa_circ_0006988) is up-regulated in pancreatic cancer tissues, plasma, and pancreatic cancer cell lines. It is associated with invasive/metastatic clinicopathological features and shows diagnostic utility, especially when combined with CA19-9."	0.6291
29343508	Annals of the rheumatic diseases	2018	Circular RNA VMA21 protects against intervertebral disc degeneration through targeting miR-200c and X linked inhibitor-of-apoptosis protein.	hsa_circ_0091702	circVMA21	hsa_circ_VMA21	VMA21	intervertebral disk degenerative disorder	MONDO:0011385	intervertebral disk degenerative disorder	down-regulated	RT-qPCR; Northern Blot; ISH	"circVMA21 is down-regulated in degenerative nucleus pulposus tissues in IVDD. It acts as a miR-200c sponge to de-repress XIAP, thereby inhibiting apoptosis and correcting extracellular-matrix anabolic/catabolic imbalance, and its intradiscal delivery alleviates IVDD in a rat puncture model."	0.8229
29361817	Cancer research and treatment	2018	Circular RNA-ZFR Inhibited Cell Proliferation and Promoted Apoptosis in Gastric Cancer by Sponging miR-130a/miR-107 and Modulating PTEN.			hsa_circ_ZFR	ZFR	gastric cancer	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"circ-ZFR is down-regulated in gastric cancer tissues and cell lines. Functionally, circ-ZFR acts as a tumor suppressor by inhibiting proliferation and cell cycle progression and promoting apoptosis, largely by sponging miR-130a and miR-107 to relieve repression of PTEN, and it suppresses tumor growth in a nude-mouse xenograft model."	0.7884
29371930	Oncotarget	2017	Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in pulmonary tuberculosis.		hsa_ circRNA_14623 / circRNA_14623			pulmonary tuberculosis	MONDO:0006052	pulmonary tuberculosis	up-regulated	RT-qPCR; RNA-seq	hsa_circRNA_14623 is significantly up-regulated in blood from PTB patients and was validated by RT-qPCR. The study suggests dysregulated circRNAs like this may participate in PTB via inferred circRNA_miRNA_mRNA (ceRNA) regulatory networks and could serve as potential non-invasive diagnostic biomarkers.	0.585
29371930	Oncotarget	2017	Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in pulmonary tuberculosis.		hsa_circ_09585 / circRNA_09585			pulmonary tuberculosis	MONDO:0006052	pulmonary tuberculosis	up-regulated	RT-qPCR; RNA-seq	hsa_circ_09585 is significantly up-regulated in blood of PTB patients and its differential expression was confirmed by RT-qPCR. The study places it among dysregulated circRNAs potentially involved in PTB through inferred ceRNA (circRNA_miRNA_mRNA) regulation.	0.585
29371930	Oncotarget	2017	Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in pulmonary tuberculosis.		hsa_circ_005538 / circRNA_05538			pulmonary tuberculosis	MONDO:0006052	pulmonary tuberculosis	down-regulated	RT-qPCR; RNA-seq	hsa_circ_005538 (circRNA_05538) is significantly down-regulated in blood of PTB patients and was validated by RT-qPCR. It is included among PTB-associated dysregulated circRNAs potentially acting through inferred ceRNA regulation.	0.585
29371930	Oncotarget	2017	Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in pulmonary tuberculosis.		hsa_circ_09993 / circRNA_09993			pulmonary tuberculosis	MONDO:0006052	pulmonary tuberculosis	down-regulated	RT-qPCR; RNA-seq	hsa_circ_09993 is significantly down-regulated in blood of PTB patients and was validated by RT-qPCR. It is implicated as part of PTB-associated dysregulated circRNAs with inferred involvement in circRNA_miRNA_mRNA (ceRNA) networks.	0.585
29371930	Oncotarget	2017	Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in pulmonary tuberculosis.		hsa_circ_13478 / circRNA_13478			pulmonary tuberculosis	MONDO:0006052	pulmonary tuberculosis	down-regulated	RT-qPCR; RNA-seq	hsa_circ_13478 is significantly down-regulated in blood from PTB patients and its change was confirmed by RT-qPCR. It is proposed to be involved in PTB through inferred circRNA-associated ceRNA regulation and may have diagnostic biomarker potential.	0.585
29371930	Oncotarget	2017	Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in pulmonary tuberculosis.		hsa_circ_00074 / circRNA_00074			pulmonary tuberculosis	MONDO:0006052	pulmonary tuberculosis	up-regulated	RT-qPCR; RNA-seq	hsa_circ_00074 is significantly up-regulated in blood from PTB patients and validated by RT-qPCR. The study suggests it may participate in PTB through inferred circRNA-associated ceRNA (circRNA_miRNA_mRNA) regulation and may have diagnostic biomarker potential.	0.585
29383123	Oncotarget	2017	Circular RNA circ-NT5C2 acts as an oncogene in osteosarcoma proliferation and metastasis through targeting miR-448.	hsa_circ_0092509	circ-NT5C2	hsa_circ_NT5C2	NT5C2	osteosarcoma	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"circ-NT5C2 is up-regulated in osteosarcoma tissues/cell lines and functions as an oncogenic circRNA. Knockdown inhibits proliferation and invasion and promotes apoptosis, and suppresses xenograft tumor growth. Mechanistically, circ-NT5C2 acts as a sponge for miR-448 and shows negative correlation with miR-448."	0.8034
29386015	Molecular cancer	2018	"Circular RNA circ-ITCH inhibits bladder cancer progression by sponging miR-17/miR-224 and regulating p21, PTEN expression."			hsa_circ_ITCH	ITCH	bladder cancer	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; Northern Blot	"circ-ITCH is down-regulated in bladder cancer and functions as a tumor suppressor. It sponges miR-17 and miR-224 to de-repress p21 and PTEN, thereby inhibiting proliferation, migration/invasion, and tumor growth while promoting G1/S arrest and apoptosis. Low circ-ITCH expression is associated with worse overall survival in BCa patients."	0.802
29391755	World journal of gastroenterology	2018	circRNA_0046366 inhibits hepatocellular steatosis by normalization of PPAR signaling.	hsa_circ_0046366		hsa_circ_FASN	FASN	hepatocellular steatosis	MONDO:0004790	fatty liver disease	down-regulated	RT-qPCR	"circRNA_0046366 is reduced in FFA-induced HepG2 hepatocellular steatosis. Restoring circRNA_0046366 antagonizes miR-34a, rescues PPARalpha expression, increases downstream lipid-metabolism genes (e.g., CPT1A and SLC27A), and reduces triglyceride accumulation, thereby alleviating the steatotic phenotype."	0.6376
29396373	Molecular metabolism	2018	Circular RNAs as novel regulators of beta-cell functions in normal and disease conditions.		circHIPK3	mmu_circ_Hipk3	Hipk3	type 2 diabetes mellitus	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RT-qPCR; RNA-seq; Microarray	"circHIPK3 is down-regulated in islets of diabetic db/db mice. Its knockdown in beta-cells impairs glucose-stimulated insulin secretion, reduces beta-cell proliferation, and increases apoptosis, potentially via sequestering multiple miRNAs (e.g., miR-124-3p, miR-338-3p) and regulating key beta-cell genes such as Akt1, Slc2a2, and Mtpn."	0.7442
29396373	Molecular metabolism	2018	Circular RNAs as novel regulators of beta-cell functions in normal and disease conditions.		ciRS-7 / CDR1as	mmu_circ_Cdr1as		type 2 diabetes mellitus	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RT-qPCR	"ciRS-7/CDR1as is down-regulated in islets from Type 2 diabetes mouse models (db/db and ob/ob). Its silencing reduces prolactin-stimulated beta-cell proliferation and tends to reduce glucose-stimulated insulin secretion, consistent with a role in beta-cell dysfunction; it is proposed to act as a miR-7 sponge."	0.6145
29415469	International journal of molecular sciences	2018	CircSMARCA5 Inhibits Migration of Glioblastoma Multiforme Cells by Regulating a Molecular Axis Involving Splicing Factors SRSF1/SRSF3/PTB.	hsa_circ_0001445	circSMARCA5	hsa_circ_SMARCA5	SMARCA5	glioblastoma	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR	"circSMARCA5 (hsa_circ_0001445) is significantly down-regulated in GBM patient biopsies and GBM cell lines. Its overexpression suppresses GBM cell migration. Mechanistically, it likely functions as an RBP modulator by tethering SRSF1, altering SRSF3 splicing (exon 4 inclusion) and linking to a splicing-factor network involving PTBP1/PTBP2."	0.6676
29415990	Cell death & disease	2018	circHIPK3 regulates cell proliferation and migration by sponging miR-124 and regulating AQP3 expression in hepatocellular carcinoma.	hsa_circ_0000284		hsa_circ_HIPK3	HIPK3	hepatocellular carcinoma	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in HCC tissues and promotes HCC cell proliferation and migration. Mechanistically, circHIPK3 sponges miR-124 to de-repress the miR-124 target AQP3, and circHIPK3 knockdown suppresses Huh7 xenograft tumor growth via the miR-124_AQP3 axis."	0.7471
29431182	International journal of oncology	2018	Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-000911/miR-449a pathway in breast carcinogenesis.		circRNA-000911			breast cancer	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	"circRNA-000911 is down-regulated in breast cancer tissues/cells and functions as a tumor suppressor. It sponges miR-449a, which relieves repression of Notch1 and leads to inhibition of NF-kappaB signaling, thereby reducing proliferation, migration and invasion and promoting apoptosis."	0.7523
29440731	Scientific reports	2018	Microarray profile of circular RNAs identifies hsa_circ_0014130 as a new circular RNA biomarker in non-small cell lung cancer.	hsa_circ_0014130		hsa_circ_PIP5K1A	PIP5K1A	non-small cell lung carcinoma	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0014130 is significantly up-regulated in NSCLC tissues and is associated with higher TNM stage and lymphatic metastasis. It shows diagnostic potential (AUC 0.878) and is predicted to act via a ceRNA-like circRNA_miRNA_mRNA network involving miR-216a-3p, miR-302a-3p, miR-892a, miR-493-5p and miR-200c-5p, with enriched pathways including MAPK and TGF-beta signaling and ubiquitin-mediated proteolysis."	0.6841
29448241	Aging	2018	Comprehensive analysis of differentially expressed profiles of Alzheimer's disease associated circular RNAs in an Alzheimer's disease mouse model.		mmu_circRNA_017963	mmu_circ_Tbc1d30	Tbc1d30	Alzheimer disease	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_017963 is significantly down-regulated in hippocampal tissue of 10-month-old SAMP8 Alzheimer¡¯s disease model mice compared with controls and younger SAMP8 mice. The study predicts it may act as a miRNA sponge (Top5 miRNAs) within a circRNA-miRNA-mRNA network, and enrichment analysis links its predicted targets to autophagosome assembly, apoptosis-related processes, and pathways such as synaptic vesicle cycle and spliceosome."	0.4851
29448241	Aging	2018	Comprehensive analysis of differentially expressed profiles of Alzheimer's disease associated circular RNAs in an Alzheimer's disease mouse model.		mmu_circRNA_003540			Alzheimer disease	MONDO:0004975	Alzheimer disease	unknown	RT-qPCR; Microarray	mmu_circRNA_003540 is one of the circRNAs validated by RT-qPCR to be differentially expressed in hippocampal tissues of SAMP8 Alzheimer¡¯s disease model mice versus SAMR1 controls and also differs between 10-month-old and 5-month-old SAMP8 mice; the study does not report the direction or mechanism for this circRNA in the provided text.	0.4468
29448241	Aging	2018	Comprehensive analysis of differentially expressed profiles of Alzheimer's disease associated circular RNAs in an Alzheimer's disease mouse model.		mmu_circRNA_013699			Alzheimer disease	MONDO:0004975	Alzheimer disease	unknown	RT-qPCR; Microarray	mmu_circRNA_013699 is validated by RT-qPCR as differentially expressed in hippocampal tissues of the SAMP8 Alzheimer¡¯s disease mouse model compared with SAMR1 controls and differs between 10-month-old and 5-month-old SAMP8 mice; no direction or mechanism is provided in the text for this circRNA.	0.4468
29448241	Aging	2018	Comprehensive analysis of differentially expressed profiles of Alzheimer's disease associated circular RNAs in an Alzheimer's disease mouse model.		mmu_circRNA_012180			Alzheimer disease	MONDO:0004975	Alzheimer disease	unknown	RT-qPCR; Microarray	"mmu_circRNA_012180 is among the circRNAs validated by RT-qPCR as differentially expressed in hippocampal tissues across SAMP8 Alzheimer¡¯s disease model comparisons, but its change direction and mechanistic role are not provided in the text."	0.4468
29448241	Aging	2018	Comprehensive analysis of differentially expressed profiles of Alzheimer's disease associated circular RNAs in an Alzheimer's disease mouse model.		mmu_circRNA_006173			Alzheimer disease	MONDO:0004975	Alzheimer disease	unknown	RT-qPCR; Microarray	"mmu_circRNA_006173 is validated by RT-qPCR as differentially expressed in hippocampal tissues in the SAMP8 Alzheimer¡¯s disease model versus controls and in an age-dependent comparison, but the study text provided does not specify the direction of change or mechanism for this circRNA."	0.4468
29467491	Leukemia	2018	"MYC-containing amplicons in acute myeloid leukemia: genomic structures, evolution, and transcriptional consequences."		circPVT1	hsa_circ_PVT1	PVT1	acute myeloid leukemia	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"circPVT1 is significantly up-regulated in AML cases with 8q24/PVT1 amplification (AML-amp) and its expression correlates with PVT1 copy-number gain. The study mentions a proposed mechanism that circPVT1 may act as a miRNA sponge (let-7/miR-125 families), but functional effects in AML are not experimentally validated here."	0.348
29483390	Chinese medical journal	2018	Identification of Circular RNAs as a Novel Biomarker for Ovarian Endometriosis.	hsa_circ_0004712	hsa_circRNA_104194			ovarian endometriosis	MONDO:0006337	ovarian endometriosis	up-regulated	RT-qPCR; Microarray	circ_0004712 is up-regulated in eutopic endometrium from patients with ovarian endometriosis versus controls and was validated by RT-qPCR. It is proposed as a diagnostic biomarker (AUC 0.704) and was used to build a predicted circRNA_miRNA_mRNA (ceRNA) network.	0.5963
29483390	Chinese medical journal	2018	Identification of Circular RNAs as a Novel Biomarker for Ovarian Endometriosis.	hsa_circ_0002198	hsa_circRNA_104195			ovarian endometriosis	MONDO:0006337	ovarian endometriosis	up-regulated	RT-qPCR; Microarray	circ_0002198 is up-regulated in eutopic endometrium from patients with ovarian endometriosis versus controls and was validated by RT-qPCR. It shows diagnostic potential (AUC 0.846) and was included in a predicted circRNA_miRNA_mRNA (ceRNA) regulatory network.	0.5963
29499937	Molecular therapy. Nucleic acids	2018	circHLA-C Plays an Important Role in Lupus Nephritis by Sponging miR-150.		circHLA-C	hsa_circ_HLA-C	HLA-C	lupus nephritis	MONDO:0005556	lupus nephritis	up-regulated	RT-qPCR; RNA-seq	"circHLA-C is up-regulated in renal biopsies from LN class IV patients and correlates positively with clinical activity measures (e.g., proteinuria and crescentic glomeruli). Mechanistically, it is predicted to act as a miRNA sponge with a perfect seed match to miR-150, suggesting a circHLA-C/miR-150 regulatory interaction in LN pathogenesis."	0.5466
29499937	Molecular therapy. Nucleic acids	2018	circHLA-C Plays an Important Role in Lupus Nephritis by Sponging miR-150.		circZNF609	hsa_circ_ZNF609	ZNF609	lupus nephritis	MONDO:0005556	lupus nephritis	up-regulated	RT-qPCR; RNA-seq	circZNF609 is significantly up-regulated in LN renal biopsies versus controls and shows correlations with one or two LN disease activity parameters. No specific miRNA target or downstream mechanism was experimentally established for circZNF609 in this paper.	0.5129
29499937	Molecular therapy. Nucleic acids	2018	circHLA-C Plays an Important Role in Lupus Nephritis by Sponging miR-150.			hsa_circ_ELK4	ELK4	lupus nephritis	MONDO:0005556	lupus nephritis	up-regulated	RT-qPCR; RNA-seq	"circEKL4/circELK4 is up-regulated in LN renal biopsies and is reported to correlate with LN disease activity measures, but the paper does not define its miRNA interactions or downstream mechanism."	0.5129
29499937	Molecular therapy. Nucleic acids	2018	circHLA-C Plays an Important Role in Lupus Nephritis by Sponging miR-150.		circFAM188A	hsa_circ_FAM188A	FAM188A	lupus nephritis	MONDO:0005556	lupus nephritis	up-regulated	RT-qPCR; RNA-seq	"circFAM188A is significantly up-regulated in LN renal biopsies and correlates with LN disease activity parameters, but specific miRNA interactions and downstream mechanisms were not defined in this study."	0.5129
29499937	Molecular therapy. Nucleic acids	2018	circHLA-C Plays an Important Role in Lupus Nephritis by Sponging miR-150.		circUBR5	hsa_circ_UBR5	UBR5	lupus nephritis	MONDO:0005556	lupus nephritis	up-regulated	RT-qPCR; RNA-seq	"circUBR5 is significantly up-regulated in LN renal biopsies and correlates with LN disease activity parameters, while its molecular mechanism was not investigated beyond expression/correlation in this work."	0.5129
29499937	Molecular therapy. Nucleic acids	2018	circHLA-C Plays an Important Role in Lupus Nephritis by Sponging miR-150.		circPDE4B	hsa_circ_PDE4B	PDE4B	lupus nephritis	MONDO:0005556	lupus nephritis	up-regulated	RT-qPCR; RNA-seq	circPDE4B is significantly up-regulated in LN renal biopsies and correlates with LN disease activity parameters; the study does not further validate its molecular mechanism.	0.5129
29499937	Molecular therapy. Nucleic acids	2018	circHLA-C Plays an Important Role in Lupus Nephritis by Sponging miR-150.		circSP100	hsa_circ_SP100	SP100	lupus nephritis	MONDO:0005556	lupus nephritis	up-regulated	RT-qPCR; RNA-seq	circSP100 is significantly up-regulated in LN renal biopsies compared with controls based on sequencing and RT-qPCR validation; no further functional mechanism or clinical correlation is detailed for circSP100 in the provided text.	0.5129
29499945	Molecular therapy. Nucleic acids	2018	circ-SHKBP1 Regulates the Angiogenesis of U87 Glioma-Exposed Endothelial Cells through miR-544a/FOXP1 and miR-379/FOXP2 Pathways.	hsa_circ_0000936		hsa_circ_SHKBP1	SHKBP1	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; ISH	"circ-SHKBP1 is up-regulated in glioma microvessels and glioma-exposed endothelial cells and promotes angiogenic phenotypes (viability, migration, tube formation). Mechanistically, it sponges miR-544a and miR-379 (Ago2/RISC-dependent), releasing FOXP1/FOXP2 to transcriptionally upregulate AGGF1, which activates PI3K/AKT and ERK1/2 signaling to drive angiogenesis."	0.7977
29507901	Hepatology communications	2018	A novel transforming growth factor beta-induced long noncoding RNA promotes an inflammatory microenvironment in human intrahepatic cholangiocarcinoma.			hsa_circ_CASC15	CASC15	intrahepatic cholangiocarcinoma 	MONDO:0003210	intrahepatic cholangiocarcinoma	unknown	RT-qPCR	"This study provides experimental evidence that TLINC (LINC00340/CASC15) generates RNase R_resistant circular isoforms detectable by divergent-primer RT-PCR in TGFbeta-treated iCCA cells and in resected human iCCA tumors. The circTLINC isoforms are proposed as potential noninvasive biomarkers for iCCA, but their mechanism and functional roles were not characterized."	0.4492
29521313	Anatolian journal of cardiology	2018	Identification of differentially expressed circular RNAs during TGF-_1-induced endothelial-to-mesenchymal transition in rat coronary artery endothelial cells.		chr5:90817794|90827570			TGF-beta1-induced endothelial-to-mesenchymal transition 	MONDO:0004992	cancer	up-regulated	RT-qPCR; RNA-seq	"chr5:90817794|90827570 is significantly up-regulated during TGF-beta1-induced EndMT in rat coronary artery endothelial cells, supported by RNA-seq and RT-qPCR. The study suggests dysregulated circRNAs may be involved in EndMT-related processes, but no specific downstream miRNA/mRNA mechanism for this circRNA was experimentally established."	0.4773
29521313	Anatolian journal of cardiology	2018	Identification of differentially expressed circular RNAs during TGF-_1-induced endothelial-to-mesenchymal transition in rat coronary artery endothelial cells.		chr8:71336875|71337745			TGF-beta1-induced endothelial-to-mesenchymal transition 	MONDO:0004992	cancer	up-regulated	RT-qPCR; RNA-seq	"chr8:71336875|71337745 is significantly up-regulated during TGF-beta1-induced EndMT in rat coronary artery endothelial cells, supported by RNA-seq and RT-qPCR. No specific interacting miRNA/target gene axis for this circRNA was experimentally validated in this study."	0.4773
29521313	Anatolian journal of cardiology	2018	Identification of differentially expressed circular RNAs during TGF-_1-induced endothelial-to-mesenchymal transition in rat coronary artery endothelial cells.		chr6:22033342|22038870			TGF-beta1-induced endothelial-to-mesenchymal transition 	MONDO:0004992	cancer	up-regulated	RT-qPCR; RNA-seq	"chr6:22033342|22038870 is significantly up-regulated during TGF-beta1-induced EndMT in rat coronary artery endothelial cells, supported by RNA-seq and RT-qPCR. The study does not experimentally define a specific miRNA/target gene mechanism for this circRNA."	0.4773
29523209	Stem cell research & therapy	2018	Signature of circular RNAs in human induced pluripotent stem cells and derived cardiomyocytes.		circSLC8A1	hsa_circ_SLC8A1	SLC8A1	dilated cardiomyopathy 	MONDO:0005021	dilated cardiomyopathy	up-regulated	RT-qPCR	"circSLC8A1 is significantly up-regulated in dilated cardiomyopathy heart tissue versus healthy controls by qRT-PCR. Its increase correlates with increased SLC8A1 linear transcripts and is sensitive to QKI knockdown in hiPSC-derived cardiomyocytes, supporting a QKI-linked biogenesis/maintenance. The study proposes circSLC8A1 as a potential biomarker indicating pathological status of heart disease."	0.2995
29535540	OncoTargets and therapy	2018	Hepatitis C virus core impacts expression of miR122 and miR204 involved in carcinogenic progression via regulation of TGFBRAP1 and HOTTIP expression.	hsa_circ_0001498	circ_0001498			hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	unknown	RT-qPCR	"In HCV core-expressing Huh7 cells (an HCV-related HCC context), the study proposes a circ_0001498/miR122/TGFBRAP1 signaling axis that may contribute to carcinogenic progression. The axis is based on prediction platform analysis and is presented as a possible mechanism associated with promoting HCC progression."	0.348
29540674	Cell death & disease	2018	circHECTD1 promotes the silica-induced pulmonary endothelial-mesenchymal transition via HECTD1.		circHECTD1	mmu_circ_HECTD1	HECTD1	silicosis 	MONDO:0005960	silicosis	up-regulated	RT-qPCR; ISH	"In SiO2-induced silicosis-related pulmonary fibrosis models, circHECTD1 is up-regulated in endothelial cells and promotes EndMT, increasing proliferation and migration. Mechanistically, circHECTD1 suppresses HECTD1 protein expression (with hectd1 mRNA unchanged after SiO2), and circHECTD1 knockdown or HECTD1 activation reverses EndMT marker changes."	0.7373
29558461	Medical science monitor : international medical journal of experimental and clinical research	2018	Molecular and Bioinformatics Analyses Identify 7 Circular RNAs Involved in Regulation of Oncogenic Transformation and Cell Proliferation in Human Bladder Cancer.	hsa_circ_0000172	hsa_circ_0000172			bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circ_0000172 is up-regulated in human bladder tumor tissues versus adjacent normal tissues (microarray and qRT-PCR). It was included in a predicted circRNA_miRNA_mRNA regulatory network and may relate to proliferation/oncogenic transformation-associated pathways at a bioinformatics level.	0.4032
29558461	Medical science monitor : international medical journal of experimental and clinical research	2018	Molecular and Bioinformatics Analyses Identify 7 Circular RNAs Involved in Regulation of Oncogenic Transformation and Cell Proliferation in Human Bladder Cancer.	hsa_circ_0002495	hsa_circ_0002495			bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circ_0002495 is up-regulated in human bladder tumor tissues versus adjacent normal tissues (microarray and qRT-PCR). It was included in a predicted circRNA_miRNA_mRNA regulatory network and may relate to proliferation/oncogenic transformation-associated pathways at a bioinformatics level.	0.4032
29558461	Medical science monitor : international medical journal of experimental and clinical research	2018	Molecular and Bioinformatics Analyses Identify 7 Circular RNAs Involved in Regulation of Oncogenic Transformation and Cell Proliferation in Human Bladder Cancer.		chr5_158368701_158368987 / Chr5: 158368701			bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"chr5_158368701_158368987 is up-regulated in bladder tumor tissues compared with adjacent normal tissues (microarray and qRT-PCR). Its downstream effects were explored only by bioinformatics prediction of miRNA/mRNA targets and pathway enrichment, without circRNA-specific mechanistic validation."	0.4032
29558461	Medical science monitor : international medical journal of experimental and clinical research	2018	Molecular and Bioinformatics Analyses Identify 7 Circular RNAs Involved in Regulation of Oncogenic Transformation and Cell Proliferation in Human Bladder Cancer.		chr22_28943661_28946139 / Chr22: 28943661			bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	chr22_28943661_28946139 is up-regulated in bladder tumor tissues compared with adjacent normal tissues (microarray and qRT-PCR). Its downstream roles were inferred through predicted miRNA/mRNA targets and pathway enrichment rather than direct mechanistic experiments.	0.4032
29558461	Medical science monitor : international medical journal of experimental and clinical research	2018	Molecular and Bioinformatics Analyses Identify 7 Circular RNAs Involved in Regulation of Oncogenic Transformation and Cell Proliferation in Human Bladder Cancer.		chr9_74522734_74523039 / Chr9: 74522734			bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; Microarray	"chr9_74522734_74523039 is down-regulated in bladder tumor tissues compared with adjacent normal tissues (microarray and qRT-PCR). The study links differential circRNAs broadly to predicted proliferation/oncogenic transformation pathways through computational target and pathway analyses, without circRNA-specific functional experiments."	0.4032
29559849	International journal of biological sciences	2018	"Overexpressed circPVT1, a potential new circular RNA biomarker, contributes to doxorubicin and cisplatin resistance of osteosarcoma cells by regulating ABCB1."	hsa_circ_0001821		hsa_circ_PVT1	PVT1	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circPVT1 is up-regulated in osteosarcoma tissues/serum and is higher in chemoresistant and metastatic groups. Functionally, circPVT1 knockdown reduces doxorubicin/cisplatin resistance and decreases ABCB1 mRNA/protein, supporting circPVT1 as a diagnostic/prognostic biomarker and a chemoresistance-related regulator in OS."	0.6527
29576969	PeerJ	2018	Identification of circularRNAs and their targets in Gossypium under Verticillium wilt stress based on RNA-seq.		ghi_circ_000009		Gh_A01G0389	Verticillium wilt	Plant diseases		dysregulated	RNA-seq	"ghi_circ_000009 is one of the circRNAs commonly differentially expressed across root comparisons under V. dahliae stress, suggesting involvement in cotton Verticillium wilt response. Its host gene Gh_A01G0389 is annotated as a D-mannose binding lectin protein potentially related to host_pathogen interactions/innate immune responses."	0.1768
29576969	PeerJ	2018	Identification of circularRNAs and their targets in Gossypium under Verticillium wilt stress based on RNA-seq.		ghi_circ_000336		Gh_D01G0335	Verticillium wilt	Plant diseases		dysregulated	RNA-seq	"ghi_circ_000336 is a Verticillium wilt-responsive circRNA (differentially expressed across root comparisons). Its host gene Gh_D01G0335 encodes an NB-ARC domain-containing NBS family disease-resistance protein, linking this circRNA to pathogen defense-related processes in cotton."	0.1768
29577053	Journal of immunology research	2018	Hsa_circ_0001859 Regulates ATF2 Expression by Functioning as an MiR-204/211 Sponge in Human Rheumatoid Arthritis.	hsa_circ_0001859				rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	dysregulated	RT-qPCR	"In rheumatoid arthritis, hsa_circ_0001859 functions as a ceRNA/miRNA sponge for miR-204/211, thereby increasing ATF2 expression. Knockdown of hsa_circ_0001859 reduces ATF2 and downstream inflammatory mediators (e.g., IL-1beta, IL-6, TNF) in SW982 cells, suggesting a pro-inflammatory role and potential therapeutic targetability."	0.5079
29581865	Oncotarget	2018	Luminal breast cancer-specific circular RNAs uncovered by a novel tool for data analysis.		Circ_ZNF91_4	hsa_circ_ZNF91	ZNF91	Breast Cancer 	MONDO:0007254	breast cancer	up-regulated	RNA-seq	"Circ_ZNF91_4 is reported as up-regulated in ER+ breast tumors versus NBO and ER_ tumors, suggesting association with the luminal subtype. The study computationally predicts many MREs for miR-23b-3p and miR-23a-3p on this circRNA, but notes these interactions require experimental validation."	0.1768
29593432	Cancer management and research	2018	Downregulation of hsa_circ_0011946 suppresses the migration and invasion of the breast cancer cell line MCF-7 by targeting RFC3.	hsa_circ_0011946		hsa_circ_SCMH1	SCMH1	breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0011946 is up-regulated in breast cancer tissues and shows higher expression in MCF-7 cells. siRNA-mediated knockdown of hsa_circ_0011946 suppresses MCF-7 cell migration and invasion and decreases RFC3 mRNA/protein; a predicted ceRNA mechanism involves sponging miR-26a/b to regulate RFC3.	0.7477
29593432	Cancer management and research	2018	Downregulation of hsa_circ_0011946 suppresses the migration and invasion of the breast cancer cell line MCF-7 by targeting RFC3.	hsa_circ_0007534				breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0007534 is up-regulated in breast cancer tissues and is included in a predicted circRNA-miRNA-mRNA network potentially regulating RFC3 through several miRNAs, but no direct functional assays for this circRNA were reported."	0.585
29593432	Cancer management and research	2018	Downregulation of hsa_circ_0011946 suppresses the migration and invasion of the breast cancer cell line MCF-7 by targeting RFC3.	hsa_circ_0093859				breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0093859 is up-regulated in breast cancer tissues and is part of a predicted circRNA-miRNA-mRNA network potentially affecting RFC3 via several miRNAs, but this study did not report specific functional perturbation experiments for hsa_circ_0093859."	0.585
29606700	Medical science monitor : international medical journal of experimental and clinical research	2018	Low Expression and Clinical Value of hsa_circ_0049224 and has_circ_0049220 in Systemic Lupus Erythematous Patients.	hsa_circ_0049224				System lupus erythematous 	MONDO:0007915	systemic lupus erythematosus	down-regulated	RT-qPCR	"hsa_circ_0049224 is significantly down-regulated in PBMCs from SLE patients and is negatively correlated with disease activity (SLEDAI). Its expression shows a positive correlation with DNMT1 levels, suggesting involvement in SLE pathogenesis and potential biomarker value related to DNA methylation status."	0.2995
29606700	Medical science monitor : international medical journal of experimental and clinical research	2018	Low Expression and Clinical Value of hsa_circ_0049224 and has_circ_0049220 in Systemic Lupus Erythematous Patients.	hsa_circ_0049220				System lupus erythematous 	MONDO:0007915	systemic lupus erythematosus	down-regulated	RT-qPCR	"has_circ_0049220 (also written as hsa_circ_0049220) is significantly down-regulated in PBMCs from SLE patients and is negatively correlated with disease activity (SLEDAI). Its expression is positively correlated with DNMT1, indicating a potential role in SLE pathogenesis and biomarker value related to DNA methylation status."	0.2995
29620202	Molecular medicine reports	2018	Identification of the tumor_suppressive function of circular RNA FOXO3 in non_small cell lung cancer through sponging miR_155.			hsa_circ_FOXO3	FOXO3	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"circRNA-FOXO3 is down-regulated in NSCLC tissues and cell lines and acts as a tumor suppressor. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-155 to increase linear FOXO3 expression, thereby inhibiting proliferation/migration/invasion and promoting apoptosis. It also shows diagnostic potential based on ROC analysis."	0.795
29620241	Molecular medicine reports	2018	Microarray expression profile analysis of circular RNAs in pancreatic cancer.		circRNA_000167 / hsa_circRNA_000167	hsa_circ_RPPH1	RPPH1	pancreatic cancer	MONDO:0009831	malignant pancreatic neoplasm	down-regulated	RT-qPCR; Microarray	circRNA_000167 (hsa_circRNA_000167; host gene RPPH1) was identified as down-regulated in pancreatic cancer tissues versus paired paracancerous tissues by microarray and validated by RT-qPCR.	0.5135
29620241	Molecular medicine reports	2018	Microarray expression profile analysis of circular RNAs in pancreatic cancer.		circRNA_100433 / hsa_circRNA_100433			pancreatic cancer	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; Microarray	circRNA_100433 (hsa_circRNA_100433) was identified as up-regulated in pancreatic cancer tissues versus paired paracancerous tissues by microarray and validated by RT-qPCR.	0.4773
29620241	Molecular medicine reports	2018	Microarray expression profile analysis of circular RNAs in pancreatic cancer.		circRNA_101717 / hsa_circRNA_101717	hsa_circ_ABCC1	ABCC1	pancreatic cancer	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; Microarray	"circRNA_101717 (hsa_circRNA_101717; host gene ABCC1) is up-regulated in pancreatic cancer and was predicted to bind miR-506; its higher level was negatively correlated with miR-506 in tumor tissues, supporting a miRNA-sponge role."	0.5135
29620241	Molecular medicine reports	2018	Microarray expression profile analysis of circular RNAs in pancreatic cancer.		circRNA_102049 / hsa_circRNA_102049	hsa_circ_TADA2A	TADA2A	pancreatic cancer	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; Microarray	"circRNA_102049 (hsa_circRNA_102049; host gene TADA2A) is up-regulated in pancreatic cancer versus paired paracancerous tissue, supported by microarray and RT-qPCR validation."	0.4773
29620241	Molecular medicine reports	2018	Microarray expression profile analysis of circular RNAs in pancreatic cancer.		circRNA_102051 / hsa_circRNA_102051	hsa_circ_TADA2A	TADA2A	pancreatic cancer	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; Microarray	"circRNA_102051 (hsa_circRNA_102051; host gene TADA2A) is up-regulated in pancreatic cancer versus paired paracancerous tissue, supported by microarray and RT-qPCR validation."	0.4773
29620241	Molecular medicine reports	2018	Microarray expression profile analysis of circular RNAs in pancreatic cancer.		circRNA_102619 / hsa_circRNA_102619 	hsa_circ_NOL10	NOL10	pancreatic cancer	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; Microarray	"circRNA_102619 (hsa_circRNA_102619; host gene NOL10) is up-regulated in pancreatic cancer versus paired paracancerous tissue, supported by microarray and RT-qPCR validation."	0.4773
29620241	Molecular medicine reports	2018	Microarray expression profile analysis of circular RNAs in pancreatic cancer.		circRNA_103076 / hsa_circRNA_103076	hsa_circ_CSE1L	CSE1L	pancreatic cancer	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; Microarray	"circRNA_103076 (hsa_circRNA_103076; host gene CSE1L) is up-regulated in pancreatic cancer and was predicted to bind miR-15a; its expression was negatively correlated with miR-15a in tumor tissues, consistent with a miRNA-sponge role."	0.5135
29620241	Molecular medicine reports	2018	Microarray expression profile analysis of circular RNAs in pancreatic cancer.		circRNA_103390 / hsa_circRNA_103390			pancreatic cancer	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; Microarray	"circRNA_103390 (hsa_circRNA_103390) is up-regulated in pancreatic cancer versus paired paracancerous tissue, supported by microarray and RT-qPCR validation."	0.4773
29620241	Molecular medicine reports	2018	Microarray expression profile analysis of circular RNAs in pancreatic cancer.		circRNA_104084 / hsa_circRNA_104084	hsa_circ_LINC00340	LINC00340	pancreatic cancer	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; Microarray	"circRNA_104084 (hsa_circRNA_104084; host gene LINC00340) is up-regulated in pancreatic cancer and was predicted to bind miR-506; its expression was negatively correlated with miR-506 in tumor tissues, consistent with a miRNA-sponge role."	0.5135
29620241	Molecular medicine reports	2018	Microarray expression profile analysis of circular RNAs in pancreatic cancer.		circRNA_104270 / hsa_circRNA_104270	hsa_circ_FAM120B	FAM120B	pancreatic cancer	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; Microarray	"circRNA_104270 (hsa_circRNA_104270; host gene FAM120B) is up-regulated in pancreatic cancer versus paired paracancerous tissue, supported by microarray and RT-qPCR validation."	0.4773
29643944	Clinical epigenetics	2018	Competing endogenous RNA expression profiling in pre-eclampsia identifies hsa_circ_0036877 as a potential novel blood biomarker for early pre-eclampsia.	hsa_circ_0036877		hsa_circ_Furin	Furin	pre-eclampsia 	MONDO:0005081	preeclampsia	dysregulated	RT-qPCR; Microarray	"hsa_circ_0036877 (host gene: Furin) is differentially expressed in pre-eclampsia, showing lower levels in PE placentas but higher levels in maternal whole peripheral blood at 24 weeks gestation. It can bind AGO2 and is predicted to sponge miR-519d-3p and miR-15b-5p, supporting a ceRNA role, and it shows potential as an early blood biomarker for PE (ROC AUC 0.846)."	0.6142
29651107	Experimental & molecular medicine	2018	Circular RNA circ-4099 is induced by TNF-alpha and regulates ECM synthesis by blocking miR-616-5p inhibition of Sox9 in intervertebral disc degeneration.	hsa_circ_0004099		hsa_circ_DENND5A	DENND5A	intervertebral disc degeneration 	MONDO:0011385	intervertebral disk degenerative disorder	up-regulated	RT-qPCR; Microarray	"In IVDD, circ-4099 is upregulated in degenerated human NP tissues and is induced by TNF-alpha via MAPK/NF-kappaB-related signaling and GRP78-dependent transcriptional regulation. Functionally, circ-4099 acts as a cytoplasmic ceRNA that sponges miR-616-5p, relieving repression of Sox9 to enhance ECM components (Collagen II, Aggrecan) and reduce inflammatory mediators, suggesting a protective/compensatory role in disc degeneration."	0.8095
29658599	Oncology reports	2018	Screening potential biomarkers for colorectal cancer based on circular RNA chips.	hsa_circ_0126897		hsa_circ_SLC4A4	SLC4A4	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0126897_CBC1 is significantly down-regulated in CRC tissues versus adjacent tissues and is proposed as a potential CRC biomarker. The study builds a predicted circRNA/miRNA network in which it is the top hub and reports decreased expression of its reported target gene SLC4A4, with broader enrichment pointing to cell-cycle-related processes."	0.5135
29674685	Cell death & disease	2018	"Exosomal circRNA_100284 from arsenite-transformed cells, via microRNA-217 regulation of EZH2, is involved in the malignant transformation of human hepatic cells by accelerating the cell cycle and promoting cell proliferation."		circRNA_100284	hsa_circ_GCLM	GCLM	arsenite-induced malignant transformation 	MONDO:0005070	neoplasm	up-regulated	RT-qPCR	"circRNA_100284 (from host gene GCLM) is upregulated during arsenite-induced malignant transformation of human hepatic epithelial cells and is enriched in exosomes released by transformed cells. Exosomal circRNA_100284 is transferred to neighboring non-transformed cells, where it sponges miR-217, leading to increased EZH2/cyclin-D1, accelerated G1/S transition, enhanced proliferation, and promotion of malignant phenotypes. Circulating exosomal circRNA_100284 is increased in sera of arsenite-exposed individuals, suggesting biomarker potential for arsenite exposure/arsenicosis."	0.5758
29682564	BioMed research international	2018	Profiling and Bioinformatic Analyses Indicate Differential circRNA and miRNA/isomiR Expression and Interactions.		circ-AGTPBP1	hsa_circ_AGTPBP1	AGTPBP1	esophageal cancer 	MONDO:0007576	esophageal cancer	up-regulated	RNA-seq	"circ-AGTPBP1 is up-regulated in esophageal squamous cancer tissues and is computationally predicted to interact with miR-490-3p, consistent with a potential miRNA-sponge/ceRNA role based on sequencing and in-silico interaction analysis."	0.1768
29682564	BioMed research international	2018	Profiling and Bioinformatic Analyses Indicate Differential circRNA and miRNA/isomiR Expression and Interactions.		circ-ANKRD17	hsa_circ_ANKRD17	ANKRD17	esophageal cancer 	MONDO:0007576	esophageal cancer	up-regulated	RNA-seq	"circ-ANKRD17 is up-regulated in esophageal squamous cancer tissues and is computationally predicted to interact with miR-490-3p and miR-124-3p, supporting a potential miRNA-sponge/ceRNA role from sequencing-based differential expression and predicted interaction networks."	0.1768
29682564	BioMed research international	2018	Profiling and Bioinformatic Analyses Indicate Differential circRNA and miRNA/isomiR Expression and Interactions.		circ-GMPS	hsa_circ_GMPS	GMPS	esophageal cancer 	MONDO:0007576	esophageal cancer	up-regulated	RNA-seq	circ-GMPS is up-regulated in esophageal squamous cancer tissues and is computationally predicted to interact with miR-490-3p and miR-217. The study further notes a putative circRNA/miRNA/mRNA relationship where the host gene GMPS is also a predicted miR-217 target.	0.1768
29682564	BioMed research international	2018	Profiling and Bioinformatic Analyses Indicate Differential circRNA and miRNA/isomiR Expression and Interactions.		circ-PAPD4	hsa_circ_PAPD4	PAPD4	esophageal cancer 	MONDO:0007576	esophageal cancer	up-regulated	RNA-seq	"circ-PAPD4 is up-regulated in esophageal squamous cancer tissues and is computationally predicted to interact with miR-124-3p, consistent with a potential miRNA-sponge relationship inferred from sequencing and in-silico interaction analysis."	0.1768
29682564	BioMed research international	2018	Profiling and Bioinformatic Analyses Indicate Differential circRNA and miRNA/isomiR Expression and Interactions.		circ-SP140L	hsa_circ_SP140L	SP140L	esophageal cancer 	MONDO:0007576	esophageal cancer	up-regulated	RNA-seq	"circ-SP140L is up-regulated in esophageal squamous cancer tissues and is predicted to interact with miR-124-3p and miR-373-3p; the paper highlights that this circRNA may interact with multiple miRNAs, consistent with a putative miRNA-sponge role from bioinformatic network analysis."	0.1768
29686222	Medical science monitor : international medical journal of experimental and clinical research	2018	"Circular RNA hsa-circ-0012129 Promotes Cell Proliferation and Invasion in 30 Cases of Human Glioma and Human Glioma Cell Lines U373, A172, and SHG44, by Targeting MicroRNA-661 (miR-661)."	hsa_circ_0012129				glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; ISH	"hsa-circ-0012129 is up-regulated in human glioma tissues and glioma cell lines and functions as an oncogenic circRNA by promoting proliferation, migration, and invasion. Mechanistically, it acts as a sponge for miR-661, negatively regulating miR-661, and miR-661 inhibition rescues the effects of hsa-circ-0012129 knockdown in vitro."	0.6815
29700215	Bioscience reports	2018	circFADS2 regulates lung cancer cells proliferation and invasion via acting as a sponge of miR-498.		hsa_circRNA_100833	hsa_circ_FADS2	FADS2	lung cancer 	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; Microarray	"circFADS2 (hsa_circRNA_100833, host gene FADS2) is up-regulated in NSCLC tissues and cell lines and promotes proliferation, migration and invasion. Mechanistically, it sponges miR-498 as supported by binding-site prediction, luciferase assays and rescue experiments with miR-498 inhibitors, and its high expression is associated with shorter overall survival."	0.814
29706607	Aging	2018	Identifying circRNA-associated-ceRNA networks in the hippocampus of Abeta1-42-induced Alzheimer's disease-like rats using microarray analysis.		rno_circRNA_008964	rno_circ_Ppp3ca	Ppp3ca	Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	up-regulated	Microarray	"rno_circRNA_008964 is up-regulated in the hippocampus of Abeta1-42-induced AD-like rats and is predicted to interact with multiple miRNAs, suggesting a potential role as a miRNA sponge within circRNA-miRNA regulatory networks in AD."	0.329
29706607	Aging	2018	Identifying circRNA-associated-ceRNA networks in the hippocampus of Abeta1-42-induced Alzheimer's disease-like rats using microarray analysis.		rno_circRNA_017759			Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR; Microarray	"rno_circRNA_017759 is strongly down-regulated in the hippocampus of Abeta1-42-induced AD-like rats and was validated by qRT-PCR, supporting its association with AD-related transcriptomic dysregulation in this model."	0.5135
29706607	Aging	2018	Identifying circRNA-associated-ceRNA networks in the hippocampus of Abeta1-42-induced Alzheimer's disease-like rats using microarray analysis.		rno_circRNA_001555			Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	unknown	RT-qPCR	"rno_circRNA_001555 was one of the circRNAs randomly selected for qRT-PCR validation, supporting the reliability of its differential expression detected by microarray in the AD-like rat hippocampus, although the direction of change is not specified in the provided text."	0.2995
29706607	Aging	2018	Identifying circRNA-associated-ceRNA networks in the hippocampus of Abeta1-42-induced Alzheimer's disease-like rats using microarray analysis.		rno_circRNA_010684	rno_circ_Golga1	Golga1	Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR; Microarray	"rno_circRNA_010684 (host gene Golga1) is up-regulated in the hippocampus of Abeta1-42-induced AD-like rats and was included among circRNAs validated by qRT-PCR, supporting the microarray finding."	0.4773
29706607	Aging	2018	Identifying circRNA-associated-ceRNA networks in the hippocampus of Abeta1-42-induced Alzheimer's disease-like rats using microarray analysis.		rno_circRNA_013981	rno_circ_Nrxn1	Nrxn1	Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	down-regulated	Microarray	rno_circRNA_013981 (host gene Nrxn1) is down-regulated in the hippocampus of Abeta1-42-induced AD-like rats based on microarray profiling; no functional mechanism was experimentally validated in the provided text.	0.279
29706616	Medical science monitor basic research	2018	Identification of Potentially Functional CircRNA-miRNA-mRNA Regulatory Network in Hepatocellular Carcinoma by Integrated Microarray Analysis.	hsa_circ_0078279				Hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	dysregulated	Microarray	"hsa_circ_0078279 is a top-ranked differentially expressed circRNA in HCC identified by integrated GEO microarray analysis. It is proposed to participate in HCC carcinogenesis through a predicted ceRNA network, including binding sites for hsa-mir-182, with downstream mRNAs enriched in cell cycle and p53 signaling-related modules."	0.1768
29706616	Medical science monitor basic research	2018	Identification of Potentially Functional CircRNA-miRNA-mRNA Regulatory Network in Hepatocellular Carcinoma by Integrated Microarray Analysis.	hsa_circ_0007456				Hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	dysregulated	Microarray	"hsa_circ_0007456 is a top-ranked differentially expressed circRNA in HCC from integrated microarray analysis. It is predicted to function as a ceRNA by binding hsa-mir-182 and potentially sponging hsa-mir-346, contributing to circRNA-miRNA-mRNA modules enriched in cell cycle and p53 signaling-related genes."	0.1768
29706616	Medical science monitor basic research	2018	Identification of Potentially Functional CircRNA-miRNA-mRNA Regulatory Network in Hepatocellular Carcinoma by Integrated Microarray Analysis.	hsa_circ_0004913				Hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	dysregulated	Microarray	"hsa_circ_0004913 is a top-ranked differentially expressed circRNA in HCC identified via integrated GEO microarray analysis. It is predicted to act in a circRNA-miRNA-mRNA (ceRNA) module by binding hsa-mir-182 and potentially sponging hsa-mir-346, with associated downstream genes enriched in cell cycle and p53 signaling-related pathways."	0.1768
29716593	Molecular cancer	2018	RNA-Seq profiling of circular RNAs in human laryngeal squamous cell carcinomas.		"hsa_circ:chr20:31876585_31,897,648"			laryngeal squamous cell carcinomas 	MONDO:0005595	laryngeal squamous cell carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ:chr20:31876585_31,897,648 is down-regulated in LSCC tumor tissues versus matched adjacent normal tissues and was validated by qRT-PCR. It may serve as a diagnostic biomarker and is suggested to act as a tumor suppressor; its miRNA-related regulatory associations were predicted bioinformatically."	0.5135
29722168	Cancer medicine	2018	A novel plasma circular RNA circFARSA is a potential biomarker for non-small cell lung cancer.		circFARSA	hsa_circ_FARSA	FARSA	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"circFARSA is up-regulated in NSCLC tumor tissues and is elevated in patient plasma, showing diagnostic potential (AUC 0.71). In A549 cells, circFARSA overexpression promotes migration and invasion, and bioinformatic analyses suggest a ceRNA mechanism where circFARSA sponges miR-330-5p/miR-326 to de-repress FASN."	0.7842
29731907	Oncology letters	2018	Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.		hsa_circRNA_406841			thyroid cancer 	MONDO:0002108	thyroid cancer	unknown	RT-qPCR; Microarray	"In FRO thyroid cancer cells, hsa_circRNA_406841 is upregulated after AGPS silencing/knockout, indicating it is AGPS-responsive in this cell model. The study provides expression profiling/validation but does not define a specific downstream function or mechanism for this circRNA."	0.4468
29731907	Oncology letters	2018	Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.		hsa_circRNA_000905			thyroid cancer 	MONDO:0002108	thyroid cancer	unknown	RT-qPCR; Microarray	hsa_circRNA_000905 is upregulated in FRO cells upon AGPS silencing/knockout versus control. The paper validates differential expression but does not assign a specific function or downstream target network for this circRNA.	0.4468
29731907	Oncology letters	2018	Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.		hsa_circRNA_019252			thyroid cancer 	MONDO:0002108	thyroid cancer	unknown	RT-qPCR; Microarray	"hsa_circRNA_019252 shows increased expression after AGPS silencing/knockout in the FRO thyroid cancer cell line. No specific biological function, pathway, or ceRNA/protein interaction mechanism is experimentally established for this circRNA in this paper."	0.4468
29731907	Oncology letters	2018	Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.		hsa_circRNA_089761			thyroid cancer	MONDO:0002108	thyroid cancer	unknown	RT-qPCR; Microarray	"hsa_circRNA_089761 is increased in AGPS sh/KO FRO thyroid cancer cells compared with control, validated by RT-qPCR. The study does not provide specific functional assays or a mechanistic axis for this circRNA."	0.4468
29731907	Oncology letters	2018	Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.		hsa_circRNA_006050			thyroid cancer	MONDO:0002108	thyroid cancer	unknown	RT-qPCR; Microarray	hsa_circRNA_006050 is upregulated following AGPS silencing/knockout in FRO thyroid cancer cells. The article does not report a specific functional role or molecular interaction network for this circRNA.	0.4468
29731907	Oncology letters	2018	Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.		hsa_circRNA_074298			thyroid cancer	MONDO:0002108	thyroid cancer	unknown	RT-qPCR; Microarray	hsa_circRNA_074298 is validated as increased after AGPS knockdown/knockout in FRO thyroid cancer cells. No direct functional or mechanistic characterization is provided for this circRNA.	0.4468
29731907	Oncology letters	2018	Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.		hsa_circRNA_066556			thyroid cancer	MONDO:0002108	thyroid cancer	unknown	RT-qPCR; Microarray	hsa_circRNA_066556 is upregulated upon AGPS silencing/knockout in FRO thyroid cancer cells. The study reports validated differential expression without detailing downstream interactions or functional effects for this circRNA.	0.4468
29731907	Oncology letters	2018	Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.		hsa_circRNA_101321			thyroid cancer	MONDO:0002108	thyroid cancer	unknown	RT-qPCR; Microarray	"hsa_circRNA_101321 is upregulated in AGPS sh/KO FRO thyroid cancer cells relative to control, supported by microarray and RT-qPCR. The paper does not provide specific downstream targets or phenotypic functions for this circRNA."	0.4468
29731907	Oncology letters	2018	Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.		hsa_circRNA_023016			thyroid cancer	MONDO:0002108	thyroid cancer	unknown	RT-qPCR; Microarray	hsa_circRNA_023016 is increased in FRO thyroid cancer cells after AGPS knockdown/knockout (validated by RT-qPCR). The study does not investigate its direct biological function or mechanism.	0.4468
29731907	Oncology letters	2018	Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.		hsa_circRNA_019744			thyroid cancer	MONDO:0002108	thyroid cancer	unknown	RT-qPCR; Microarray	"hsa_circRNA_019744 is upregulated after AGPS silencing/knockout in the FRO thyroid cancer cell line, based on microarray and RT-qPCR. The study does not characterize its downstream mechanism or functional impact."	0.4468
29731907	Oncology letters	2018	Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.		hsa_circRNA_404686			thyroid cancer 	MONDO:0002108	thyroid cancer	unknown	RT-qPCR; Microarray	"hsa_circRNA_404686 is downregulated in FRO thyroid cancer cells after AGPS silencing/knockout versus control, supported by microarray and RT-qPCR. No further functional/mechanistic characterization is provided for this circRNA."	0.4468
29731907	Oncology letters	2018	Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.		hsa_circRNA_000367			thyroid cancer	MONDO:0002108	thyroid cancer	unknown	RT-qPCR; Microarray	hsa_circRNA_000367 is decreased after AGPS silencing/knockout in FRO thyroid cancer cells (microarray and RT-qPCR). The work does not establish a functional phenotype or mechanistic axis for this circRNA.	0.4468
29731907	Oncology letters	2018	Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.		hsa_circRNA_001729			thyroid cancer	MONDO:0002108	thyroid cancer	unknown	RT-qPCR; Microarray	"hsa_circRNA_001729 is downregulated upon AGPS silencing/knockout in the FRO thyroid cancer cell line, as confirmed by RT-qPCR. The paper does not provide functional experiments defining its role in thyroid cancer biology."	0.4468
29731907	Oncology letters	2018	Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.		hsa_circRNA_004183			thyroid cancer	MONDO:0002108	thyroid cancer	unknown	RT-qPCR; Microarray	"hsa_circRNA_004183 is decreased in AGPS sh/KO FRO thyroid cancer cells compared with control, supported by microarray and RT-qPCR. The paper does not provide downstream targets or functional consequences for this circRNA."	0.4468
29731907	Oncology letters	2018	Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.		hsa_circRNA_100790			thyroid cancer	MONDO:0002108	thyroid cancer	unknown	RT-qPCR; Microarray	"hsa_circRNA_100790 is downregulated when AGPS is silenced/knocked out in FRO thyroid cancer cells, validated by RT-qPCR. No mechanistic or functional follow-up is reported for this circRNA."	0.4468
29731907	Oncology letters	2018	Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.		hsa_circRNA_104270			thyroid cancer	MONDO:0002108	thyroid cancer	unknown	RT-qPCR; Microarray	hsa_circRNA_104270 is decreased in AGPS sh/KO FRO thyroid cancer cells compared with control (validated by RT-qPCR). The study does not report a specific mechanism or functional impact for this circRNA.	0.4468
29731907	Oncology letters	2018	Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.		hsa_circRNA_102049			thyroid cancer	MONDO:0002108	thyroid cancer	unknown	RT-qPCR; Microarray	hsa_circRNA_102049 is downregulated after AGPS knockdown/knockout in FRO thyroid cancer cells (microarray and RT-qPCR). No specific molecular mechanism or functional phenotype is described for this circRNA.	0.4468
29731907	Oncology letters	2018	Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.		hsa_circRNA_406494			thyroid cancer	MONDO:0002108	thyroid cancer	unknown	RT-qPCR; Microarray	"hsa_circRNA_406494 is reduced in AGPS sh/KO FRO thyroid cancer cells compared with control, with RT-qPCR confirmation. The study does not investigate specific downstream targets or functions of this circRNA."	0.4468
29731907	Oncology letters	2018	Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.		hsa_circRNA_100787			thyroid cancer	MONDO:0002108	thyroid cancer	unknown	RT-qPCR; Microarray	"hsa_circRNA_100787 is downregulated in FRO thyroid cancer cells after AGPS silencing/knockout compared with control, with RT-qPCR validation. The study does not further characterize its role or targets."	0.4468
29731907	Oncology letters	2018	Effect of alkylglycerone phosphate synthase on the expression profile of circRNAs in the human thyroid cancer cell line FRO.		hsa_circRNA_082319			thyroid cancer	MONDO:0002108	thyroid cancer	unknown	RT-qPCR; Microarray	"hsa_circRNA_082319 is downregulated after AGPS silencing/knockout in FRO thyroid cancer cells, confirmed by RT-qPCR. No additional functional or mechanistic experiments are presented for this circRNA."	0.4468
29748605	Cell death & disease	2018	Targeting circular RNA-ZRANB1 for therapeutic intervention in retinal neurodegeneration.	hsa_circ_0000268		hsa_circ_ZRANB1	ZRANB1	glaucoma 	MONDO:0005041	glaucoma	up-regulated	RT-qPCR	"cZRANB1 is up-regulated in glaucoma-associated retinal neurodegeneration and contributes to reactive gliosis and glial activation. Silencing cZRANB1 reduces M¨¹ller cell proliferation/activation and indirectly protects RGCs, mainly via a ceRNA mechanism involving miR-217 and RUNX2."	0.7659
29748605	Cell death & disease	2018	Targeting circular RNA-ZRANB1 for therapeutic intervention in retinal neurodegeneration.	mmu_circ_0013957		mmu_circ_ZRANB1	ZRANB1	glaucoma 	MONDO:0005041	glaucoma	up-regulated	RT-qPCR	"cZRANB1 is up-regulated in glaucoma-associated retinal neurodegeneration and contributes to reactive gliosis and glial activation. Silencing cZRANB1 reduces M¨¹ller cell proliferation/activation and indirectly protects RGCs, mainly via a ceRNA mechanism involving miR-217 and RUNX2."	0.7659
29765512	Oncotarget	2018	DHX9 regulates production of hepatitis B virus-derived circular RNA and viral protein levels.		HBV-derived circular RNA			Hepatitis B virus (HBV) infection 	MONDO:0005344	hepatitis B virus infection	up-regulated	RT-qPCR; Northern Blot	"This study identifies HBV-derived circular RNA generated during HBV replication. DHX9 knockdown increases HBV circular RNA abundance, which is associated with reduced viral surface protein levels, suggesting circularization reduces available RNA templates for translation. HBV circular RNA physically associates with DHX9 and ribosomal P0/P1/P2."	0.7446
29785124	OncoTargets and therapy	2018	"Upregulation of circ_0066444 promotes the proliferation, invasion, and migration of gastric cancer cells."	hsa_circ_0066444	circ_0066444	hsa_circ_ADAMTS9	ADAMTS9	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_0066444 is upregulated in gastric cancer tissues and correlates with lymph node metastasis. Functionally, circ_0066444 promotes GC cell proliferation, migration, and invasion in vitro, and is proposed to act through a predicted circRNA_miRNA_mRNA (ceRNA) network."	0.6148
29785229	Disease markers	2018	The Circular RNA hsa_circ_0001445 Regulates the Proliferation and Migration of Hepatocellular Carcinoma and May Serve as a Diagnostic Biomarker.	hsa_circ_0001445	circSMARCA5	hsa_circ_SMARCA5	SMARCA5	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"hsa_circ_0001445 (circSMARCA5), derived from SMARCA5, is down-regulated in HCC tissues and in several HCC cell lines. Its overexpression promotes apoptosis and suppresses proliferation, migration and invasion, consistent with a tumor-suppressive role. Plasma hsa_circ_0001445 is reduced in HCC and shows diagnostic potential by ROC analysis, especially when combined with AFP."	0.6148
29789629	Scientific reports	2018	"Non-coding RNAs in Various Stages of Liver Disease Leading to Hepatocellular Carcinoma: Differential Expression of miRNAs, piRNAs, lncRNAs, circRNAs, and sno/mt-RNAs."	hsa_circ_0040679	circR-0040679			cirrhosis	MONDO:0005155	cirrhosis of liver	up-regulated	RNA-seq	hsa_circ_0040679 is reported as significantly up-regulated across multiple stages of liver disease progression toward HCC based on public small RNA-seq reanalysis; no functional/mechanistic validation was provided.	0.1768
29789629	Scientific reports	2018	"Non-coding RNAs in Various Stages of Liver Disease Leading to Hepatocellular Carcinoma: Differential Expression of miRNAs, piRNAs, lncRNAs, circRNAs, and sno/mt-RNAs."	hsa_circ_0015774	circR-0015774			cirrhosis	MONDO:0005155	cirrhosis of liver	up-regulated	RNA-seq	"hsa_circ_0015774 is consistently up-regulated across stages of liver disease progressing to HCC in the analyzed public small RNA-seq datasets and is proposed as a potential biomarker, without functional validation."	0.1768
29789629	Scientific reports	2018	"Non-coding RNAs in Various Stages of Liver Disease Leading to Hepatocellular Carcinoma: Differential Expression of miRNAs, piRNAs, lncRNAs, circRNAs, and sno/mt-RNAs."	hsa_circ_0016456	circR-0016456			cirrhosis	MONDO:0005155	cirrhosis of liver	up-regulated	RNA-seq	hsa_circ_0016456 is identified as up-regulated in cirrhosis and strongly up-regulated in HCC compared with healthy liver in the sequencing-based differential expression analysis; no mechanistic role is tested.	0.1768
29789629	Scientific reports	2018	"Non-coding RNAs in Various Stages of Liver Disease Leading to Hepatocellular Carcinoma: Differential Expression of miRNAs, piRNAs, lncRNAs, circRNAs, and sno/mt-RNAs."	hsa_circ_0016456	circR-0016456			hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RNA-seq	hsa_circ_0016456 is identified as up-regulated in cirrhosis and strongly up-regulated in HCC compared with healthy liver in the sequencing-based differential expression analysis; no mechanistic role is tested.	0.1768
29789629	Scientific reports	2018	"Non-coding RNAs in Various Stages of Liver Disease Leading to Hepatocellular Carcinoma: Differential Expression of miRNAs, piRNAs, lncRNAs, circRNAs, and sno/mt-RNAs."	hsa_circ_0015637	circR-0015637			cirrhosis	MONDO:0005155	cirrhosis of liver	up-regulated	RNA-seq	hsa_circ_0015637 shows strong up-regulation across multiple liver disease stages (cirrhosis through HCC) in sequencing-based differential expression; no functional mechanism is experimentally established.	0.1768
29789629	Scientific reports	2018	"Non-coding RNAs in Various Stages of Liver Disease Leading to Hepatocellular Carcinoma: Differential Expression of miRNAs, piRNAs, lncRNAs, circRNAs, and sno/mt-RNAs."	hsa_circ_0014848	circR-0014848			cirrhosis	MONDO:0005155	cirrhosis of liver	up-regulated	RNA-seq	hsa_circ_0014848 is up-regulated in cirrhosis and LGDN and remains up-regulated in HCC in the sequencing-based differential expression analysis; functional roles were not experimentally determined.	0.1768
29789629	Scientific reports	2018	"Non-coding RNAs in Various Stages of Liver Disease Leading to Hepatocellular Carcinoma: Differential Expression of miRNAs, piRNAs, lncRNAs, circRNAs, and sno/mt-RNAs."	hsa_circ_0035409	circR-0035409			cirrhosis	MONDO:0005155	cirrhosis of liver	down-regulated	RNA-seq	"hsa_circ_0035409 is consistently down-regulated across all assessed liver disease stages including HCC in the sequencing-based analysis and is proposed as a potential biomarker, without functional validation."	0.1768
29789629	Scientific reports	2018	"Non-coding RNAs in Various Stages of Liver Disease Leading to Hepatocellular Carcinoma: Differential Expression of miRNAs, piRNAs, lncRNAs, circRNAs, and sno/mt-RNAs."	hsa_circ_0035407	circR-0035407			cirrhosis	MONDO:0005155	cirrhosis of liver	down-regulated	RNA-seq	hsa_circ_0035407 is consistently down-regulated across all assessed disease stages including HCC in the sequencing-based differential expression analysis; functional roles are not experimentally examined.	0.1768
29789629	Scientific reports	2018	"Non-coding RNAs in Various Stages of Liver Disease Leading to Hepatocellular Carcinoma: Differential Expression of miRNAs, piRNAs, lncRNAs, circRNAs, and sno/mt-RNAs."	hsa_circ_0092360	circR-0092360			cirrhosis	MONDO:0005155	cirrhosis of liver	down-regulated	RNA-seq	hsa_circ_0092360 is repeatedly detected as down-regulated across multiple liver disease stages including HCC in the sequencing-based differential expression analysis; no functional experiments were performed.	0.1768
29789629	Scientific reports	2018	"Non-coding RNAs in Various Stages of Liver Disease Leading to Hepatocellular Carcinoma: Differential Expression of miRNAs, piRNAs, lncRNAs, circRNAs, and sno/mt-RNAs."	hsa_circ_0043980	circR-0043980			cirrhosis	MONDO:0005155	cirrhosis of liver	down-regulated	RNA-seq	hsa_circ_0043980 is identified as down-regulated across liver disease stages including HCC in the sequencing-based differential expression analysis; no function/mechanism is validated.	0.1768
29789629	Scientific reports	2018	"Non-coding RNAs in Various Stages of Liver Disease Leading to Hepatocellular Carcinoma: Differential Expression of miRNAs, piRNAs, lncRNAs, circRNAs, and sno/mt-RNAs."	hsa_circ_0007956	circR-0007956			cirrhosis	MONDO:0005155	cirrhosis of liver	down-regulated	RNA-seq	hsa_circ_0007956 is identified as down-regulated across liver disease stages including HCC in the sequencing-based differential expression analysis; no mechanistic studies are presented.	0.1768
29789629	Scientific reports	2018	"Non-coding RNAs in Various Stages of Liver Disease Leading to Hepatocellular Carcinoma: Differential Expression of miRNAs, piRNAs, lncRNAs, circRNAs, and sno/mt-RNAs."	hsa_circ_0021905	circR-0021905			hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RNA-seq	hsa_circ_0021905 is extremely up-regulated and described as specifically altered in HCC versus healthy liver in the sequencing-based analysis; functional and mechanistic validation is not provided.	0.1768
29789629	Scientific reports	2018	"Non-coding RNAs in Various Stages of Liver Disease Leading to Hepatocellular Carcinoma: Differential Expression of miRNAs, piRNAs, lncRNAs, circRNAs, and sno/mt-RNAs."	hsa_circ_0087119	circR-0087119			cirrhosis	MONDO:0005155	cirrhosis of liver	up-regulated	RNA-seq	hsa_circ_0087119 is reported as up-regulated across multiple liver disease stages (including HCC) in the sequencing-based analysis; no functional validation is provided.	0.1768
29789629	Scientific reports	2018	"Non-coding RNAs in Various Stages of Liver Disease Leading to Hepatocellular Carcinoma: Differential Expression of miRNAs, piRNAs, lncRNAs, circRNAs, and sno/mt-RNAs."	hsa_circ_0054435	circR-0054435			cirrhosis	MONDO:0005155	cirrhosis of liver	up-regulated	RNA-seq	hsa_circ_0054435 is identified as up-regulated in cirrhosis and strongly up-regulated in HGDN in the sequencing-based differential expression analysis; no functional studies are presented.	0.1768
29789629	Scientific reports	2018	"Non-coding RNAs in Various Stages of Liver Disease Leading to Hepatocellular Carcinoma: Differential Expression of miRNAs, piRNAs, lncRNAs, circRNAs, and sno/mt-RNAs."	hsa_circ_0087948	circR-0087948			cirrhosis	MONDO:0005155	cirrhosis of liver	up-regulated	RNA-seq	hsa_circ_0087948 is up-regulated across multiple liver disease stages and is among the top up-regulated circRNAs in eHCC in the sequencing-based analysis; no functional validation is shown.	0.1768
29789629	Scientific reports	2018	"Non-coding RNAs in Various Stages of Liver Disease Leading to Hepatocellular Carcinoma: Differential Expression of miRNAs, piRNAs, lncRNAs, circRNAs, and sno/mt-RNAs."	hsa_circ_0008347	circR-0008347			cirrhosis	MONDO:0005155	cirrhosis of liver	up-regulated	RNA-seq	hsa_circ_0008347 is consistently up-regulated across multiple liver disease stages including HCC based on sequencing differential expression; no functional mechanism is investigated.	0.1768
29789629	Scientific reports	2018	"Non-coding RNAs in Various Stages of Liver Disease Leading to Hepatocellular Carcinoma: Differential Expression of miRNAs, piRNAs, lncRNAs, circRNAs, and sno/mt-RNAs."	hsa_circ_0076872	circR-0076872			cirrhosis	MONDO:0005155	cirrhosis of liver	down-regulated	RNA-seq	hsa_circ_0076872 is consistently down-regulated across liver disease stages including HCC in the sequencing-based differential expression analysis; no mechanistic evidence is provided.	0.1768
29789629	Scientific reports	2018	"Non-coding RNAs in Various Stages of Liver Disease Leading to Hepatocellular Carcinoma: Differential Expression of miRNAs, piRNAs, lncRNAs, circRNAs, and sno/mt-RNAs."	hsa_circ_0069970	circR-0069970			cirrhosis	MONDO:0005155	cirrhosis of liver	down-regulated	RNA-seq	hsa_circ_0069970 is down-regulated across liver disease stages including HCC in the sequencing-based differential expression analysis; no functional characterization is provided.	0.1768
29794795	Medicine	2018	Expression profile of circular RNAs in infantile hemangioma detected by RNA-Seq.		hsa_circRNA001885		FAM117B	infantile hemangioma 	MONDO:0006500	hemangioma	up-regulated	RT-qPCR; RNA-seq	"hsa_circRNA001885 is significantly up-regulated in infantile hemangioma skin compared with matched normal skin and was validated by qRT-PCR in an independent patient set. Its miRNA-binding sites were computationally predicted, suggesting a potential miRNA-sponge (ceRNA) role, but no downstream targets or functional assays were experimentally confirmed."	0.4032
29794795	Medicine	2018	Expression profile of circular RNAs in infantile hemangioma detected by RNA-Seq.		hsa_circRNA006612			infantile hemangioma 	MONDO:0006500	hemangioma	up-regulated	RT-qPCR; RNA-seq	"hsa_circRNA006612 is significantly up-regulated in infantile hemangioma skin compared with matched normal skin and was validated by qRT-PCR in an independent patient set. Its miRNA-binding sites were computationally predicted, implying a potential miRNA-sponge (ceRNA) role, but no specific downstream targets or functional effects were experimentally established."	0.4032
29794795	Medicine	2018	Expression profile of circular RNAs in infantile hemangioma detected by RNA-Seq.		hsa_circRNA000227			infantile hemangioma 	MONDO:0006500	hemangioma	unknown	RNA-seq	"hsa_circRNA000227 was included among the validated circRNAs for which miRNA response elements were computationally predicted. The study reports many predicted miRNA interactions (63), but does not provide the expression direction in IH or experimental validation of any specific miRNA-mediated downstream effects for this circRNA."	0.1768
29795334	Cell death and differentiation	2018	Enhanced breast cancer progression by mutant p53 is inhibited by the circular RNA circ-Ccnb1.		circ-Ccnb1	hsa_circ_CCNB1	CCNB1	breast carcinoma 	MONDO:0004989	breast carcinoma	down-regulated	RT-qPCR; Northern Blot; Microarray	"circ-Ccnb1 is down-regulated in breast carcinoma tissues. Functionally, circ-Ccnb1 suppresses growth and promotes apoptosis of p53-mutant breast cancer cells by forming a circ-Ccnb1_H2AX_Bclaf1 complex, thereby inhibiting xenograft tumor growth and prolonging mouse survival."	0.8687
29798970	Medical science monitor : international medical journal of experimental and clinical research	2018	Circular RNA Myosin Light Chain Kinase (MYLK) Promotes Prostate Cancer Progression through Modulating Mir-29a Expression.	hsa_circ_0141940		hsa_circ_MYLK	MYLK	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circRNA-MYLK (hsa_circ_0141940) is up-regulated in prostate cancer tissues and cell lines. It promotes PCa cell proliferation/colony formation, invasion, migration and wound healing, while inhibiting apoptosis, at least partly by targeting and downregulating miR-29a."	0.5751
29805712	Journal of Cancer	2018	"Circular RNA circ_HIPK3 is down-regulated and suppresses cell proliferation, migration and invasion in osteosarcoma."		circ_HIPK3 / circHIPK3	hsa_circ_HIPK3	HIPK3	osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR	"circHIPK3 is consistently down-regulated in osteosarcoma cell lines, tumor tissues and patient plasma. Functionally, circHIPK3 overexpression suppresses osteosarcoma cell proliferation/colony formation and inhibits migration and invasion, suggesting a tumor-suppressive role. Clinically, lower circHIPK3 is associated with advanced stage/lung metastasis and worse overall survival, and plasma circHIPK3 shows diagnostic potential by ROC analysis."	0.6568
29844435	Cell death & disease	2018	Profiling and functional analysis of circular RNAs in acute promyelocytic leukemia and their dynamic regulation during all-trans retinoic acid treatment.		circ-HIPK2	hsa_circ_HIPK2	HIPK2	acute promyelocytic leukemia 	MONDO:0012883	acute promyelocytic leukemia	down-regulated	RT-qPCR; RNA-seq	"In APL cells, circ-HIPK2 is down-regulated in patient samples and is required to support ATRA-induced differentiation. Mechanistically, it localizes mainly in the cytoplasm and functions as a miRNA sponge, particularly for miR-124-3p, with a proposed downstream impact on CEBPA protein level. circ-HIPK2 may serve as an APL biomarker because its expression increases at complete remission."	0.7629
29844683	OncoTargets and therapy	2018	circSMAD2 inhibits the epithelial-mesenchymal transition by targeting miR-629 in hepatocellular carcinoma.	hsa_circ_0000847		hsa_circ_SMAD2	SMAD2	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"circSMAD2 is down-regulated in hepatocellular carcinoma tissues and HCC cell lines. Functionally, circSMAD2 suppresses migration, invasion and EMT in HCC cells by binding/negatively regulating miR-629, and miR-629 overexpression reverses these inhibitory effects."	0.7581
29849467	Cancer management and research	2018	Screening differential circular RNA expression profiles reveal that hsa_circ_0128298 is a biomarker in the diagnosis and prognosis of hepatocellular carcinoma.	hsa_circ_0128298				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0128298 is significantly up-regulated in hepatocellular carcinoma tissues versus paratumorous tissues. Higher expression is associated with metastasis-related clinicopathological features and predicts worse overall survival, and it shows moderate diagnostic value by ROC analysis."	0.5416
29854278	Oncotarget	2018	Identification and functional characterization of circRNA-0008717 as an oncogene in osteosarcoma through sponging miR-203.	hsa_circ_0008717		hsa_circ_ABCB10	ABCB10	osteosarcoma	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"circRNA-0008717 (circ-ABCB10) is up-regulated in osteosarcoma tissues/serum and promotes malignant phenotypes (proliferation, migration, invasion) while inhibiting apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-203, thereby increasing Bmi-1 expression. High circRNA-0008717 expression is associated with poor patient survival and shows diagnostic potential by ROC analysis."	0.8229
29855336	Journal of hematology & oncology	2018	The role of HGF-MET pathway and CCDC66 cirRNA expression in EGFR resistance and epithelial-to-mesenchymal transition of lung adenocarcinoma cells.			hsa_circ_CCDC66	CCDC66	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"cirRNA CCDC66 is up-regulated in lung adenocarcinoma specimens/cells and is regulated by HGF/c-Met and FAK (and negatively by nAchRalpha7). Functional perturbation shows it promotes EMT-marker expression and invasion, and is implicated in drug-resistance phenotypes in LADC cells."	0.3963
29866032	BMC plant biology	2018	Re-analysis of long non-coding RNAs and prediction of circRNAs reveal their novel roles in susceptible tomato following TYLCV infection.		slcirc108		Solyc07g043420.2.1	Tomato yellow leaf curl virus (TYLCV) infection 	Plant diseases		down-regulated	RT-qPCR	Slcirc108 is an exonic tomato circRNA derived from Solyc07g043420.2.1. It is significantly down-regulated upon TYLCV infection and its expression correlates positively with its host gene; the study did not support a miRNA-sponge role for tomato circRNAs in this context.	0.4276
29866032	BMC plant biology	2018	Re-analysis of long non-coding RNAs and prediction of circRNAs reveal their novel roles in susceptible tomato following TYLCV infection.		Slcirc017		Solyc01g080200.2	Tomato yellow leaf curl virus (TYLCV) infection 	Plant diseases		up-regulated	RNA-seq	Slcirc017 is an exonic tomato circRNA whose expression increases after TYLCV infection and is reported to correlate with up-regulation of its host gene Solyc01g080200.2. No miRNA binding was predicted for tomato circRNAs in this study.	0.1768
29884225	Arthritis research & therapy	2018	CircIBTK inhibits DNA demethylation and activation of AKT signaling pathway via miR-29b in peripheral blood mononuclear cells in systemic lupus erythematosus.	hsa_circ_0077179	CircIBTK	hsa_circ_IBTK	IBTK	systemic lupus erythematosus 	MONDO:0007915	systemic lupus erythematosus	down-regulated	RT-qPCR; RNA-seq	"circIBTK (hsa_circ_0077179), derived from IBTK, is down-regulated in SLE PBMCs and mainly localized in the cytoplasm. It sponges miR-29b, thereby counteracting miR-29b-driven global DNA demethylation and PTEN suppression, leading to reduced AKT pathway activation; it also shows potential diagnostic/monitoring value via correlations with SLEDAI and ROC analysis."	0.8271
29891014	Respiratory research	2018	Hsa_circ_0046264 up-regulated BRCA2 to suppress lung cancer through targeting hsa-miR-1245.	hsa_circ_0046264				lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR; Microarray	"In lung cancer, hsa_circ_0046264 is down-regulated and functions as a tumor suppressor. It sponges miR-1245 to de-repress BRCA2, thereby inhibiting cell viability/proliferation and invasion and promoting apoptosis; overexpression suppresses tumor growth in a nude mouse xenograft model."	0.8066
29910675	International journal of medical sciences	2018	Differential Expression of CircRNAs in Embryonic Heart Tissue Associated with Ventricular Septal Defect.		hsa_circRNA_002086	hsa_circ_LOC401320	LOC401320	ventricular septal defect 	MONDO:0002070	ventricular septal defect	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_002086 is significantly up-regulated in fetal myocardial tissue from VSD cases versus controls, identified by circRNA microarray and validated by qRT-PCR. The study suggests circRNAs may act via miRNA sponging or protein binding in VSD, but no specific mechanism was validated for this circRNA."	0.4032
29910675	International journal of medical sciences	2018	Differential Expression of CircRNAs in Embryonic Heart Tissue Associated with Ventricular Septal Defect.		hsa_circRNA_007878	hsa_circ_MAP4	MAP4	ventricular septal defect 	MONDO:0002070	ventricular septal defect	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_007878 is significantly down-regulated in fetal heart tissue from VSD cases versus controls by microarray and qRT-PCR. Bioinformatic prediction suggests it may bind hsa-miR-196a-5p, but downstream targets and functional effects were not experimentally tested."	0.4032
29910675	International journal of medical sciences	2018	Differential Expression of CircRNAs in Embryonic Heart Tissue Associated with Ventricular Septal Defect.		hsa_circRNA_100709	hsa_circ_FAM53B	FAM53B	ventricular septal defect 	MONDO:0002070	ventricular septal defect	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_100709 is significantly down-regulated in VSD fetal myocardial tissue compared with normal controls, detected by microarray and validated by qRT-PCR. The study did not validate any specific downstream mechanism or pathway for this circRNA."	0.4032
29910675	International journal of medical sciences	2018	Differential Expression of CircRNAs in Embryonic Heart Tissue Associated with Ventricular Septal Defect.		hsa_circRNA_101965			ventricular septal defect 	MONDO:0002070	ventricular septal defect	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_101965 is significantly down-regulated in VSD fetal myocardial tissue versus normal controls based on microarray screening and qRT-PCR validation. No specific miRNA targets, downstream genes, or pathways were validated for this circRNA in this study."	0.4032
29910675	International journal of medical sciences	2018	Differential Expression of CircRNAs in Embryonic Heart Tissue Associated with Ventricular Septal Defect.		hsa_circRNA_402565	hsa_circ_EDEM2	EDEM2	ventricular septal defect 	MONDO:0002070	ventricular septal defect	down-regulated	RT-qPCR; Microarray	hsa_circRNA_402565 is significantly down-regulated in fetal myocardial tissue from VSD cases compared with normal controls (microarray and qRT-PCR). The study provides only predictive bioinformatics context and does not validate a specific mechanism or pathway for this circRNA.	0.4032
29922161	Frontiers in pharmacology	2018	Circular RNA Signature Predicts Gemcitabine Resistance of Pancreatic Ductal Adenocarcinoma.		chr14:101402109-101464448+	hsa_circ_SNORD114-1	SNORD114-1	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"chr14:101402109-101464448+ is significantly up-regulated in gemcitabine-resistant PDAC models and in plasma of gemcitabine non-responsive PDAC patients. Functional assays show it promotes gemcitabine resistance and reduces gemcitabine-induced apoptosis, and it is predicted to interact with miRNAs such as miR-145-5p."	0.5923
29922161	Frontiers in pharmacology	2018	Circular RNA Signature Predicts Gemcitabine Resistance of Pancreatic Ductal Adenocarcinoma.		chr4:52729603-52780244+	hsa_circ_DCUN1D4	DCUN1D4	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	chr4:52729603-52780244+ is significantly up-regulated in gemcitabine-resistant PDAC models and in plasma of gemcitabine non-responsive PDAC patients. Knockdown restores gemcitabine sensitivity and increases apoptosis under gemcitabine; overexpression increases resistance in PANC-1 (but shows limited resistance phenotype in MIA PACA-2). It is predicted to interact with miRNAs such as miR-145-5p.	0.5923
29922514	PeerJ	2018	Comprehensive circular RNA expression profile in radiation-treated HeLa cells and analysis of radioresistance-related circRNAs.	hsa_circ_0009035				cervical cancer	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0009035 is significantly up-regulated in irradiated (radiation-treated) HeLa cells versus sham-irradiated controls, indicating association with the radiation response/radioresistance context in this cervical cancer cell model."	0.1904
29922514	PeerJ	2018	Comprehensive circular RNA expression profile in radiation-treated HeLa cells and analysis of radioresistance-related circRNAs.	hsa_circ_0000392				cervical cancer	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000392 is significantly up-regulated after irradiation in HeLa cells, supporting its association with the cellular response to radiation in a cervical cancer model."	0.1904
29922514	PeerJ	2018	Comprehensive circular RNA expression profile in radiation-treated HeLa cells and analysis of radioresistance-related circRNAs.	hsa_circ_0004913	hg38_circ_0004913			cervical cancer	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; RNA-seq	"hg38_circ_0004913 is experimentally validated (qRT-PCR) to be up-regulated in irradiated versus control HeLa cells, suggesting involvement in radiation response in this cervical cancer cell model."	0.1904
29922514	PeerJ	2018	Comprehensive circular RNA expression profile in radiation-treated HeLa cells and analysis of radioresistance-related circRNAs.	hsa_circ_0004015				cervical cancer	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0004015 is up-regulated in irradiated HeLa cells and is highlighted in a predicted circRNA_miRNA_mRNA network, where it may sponge several miRNAs (e.g., hsa-miR-3163) to regulate multiple target genes relevant to radioresistance."	0.2465
29922514	PeerJ	2018	Comprehensive circular RNA expression profile in radiation-treated HeLa cells and analysis of radioresistance-related circRNAs.	hsa_circ_0013682	hg38_circ_0013682			cervical cancer	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR; RNA-seq	"hg38_circ_0013682 is significantly down-regulated in irradiated versus control HeLa cells, indicating a radiation-responsive circRNA in this cervical cancer cell model."	0.1904
29922514	PeerJ	2018	Comprehensive circular RNA expression profile in radiation-treated HeLa cells and analysis of radioresistance-related circRNAs.	hsa_circ_0015954	hg38_circ_0015954			cervical cancer	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR; RNA-seq	"hg38_circ_0015954 is significantly down-regulated in irradiated HeLa cells compared with controls, supporting its association with the radiation response in this cervical cancer cell model."	0.1904
29922514	PeerJ	2018	Comprehensive circular RNA expression profile in radiation-treated HeLa cells and analysis of radioresistance-related circRNAs.	hsa_circ_0013738				cervical cancer	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0013738 is significantly down-regulated upon irradiation in HeLa cells, indicating it is part of the radiation-associated circRNA expression changes in this cervical cancer model."	0.1904
29922514	PeerJ	2018	Comprehensive circular RNA expression profile in radiation-treated HeLa cells and analysis of radioresistance-related circRNAs.	hsa_circ_0013225				cervical cancer	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0013225 is significantly down-regulated in irradiated HeLa cells relative to controls, supporting it as a radiation-responsive circRNA in this cervical cancer model."	0.1904
29930739	Theranostics	2018	Circular RNA-ZNF609 regulates retinal neurodegeneration by acting as miR-615 sponge.	mmu_circ_0001797	cZNF609	mmu_circ_ZNF609	ZNF609	glaucoma 	MONDO:0005041	glaucoma	up-regulated	RT-qPCR	"In rat glaucoma models, cZNF609 is up-regulated and promotes retinal neurodegeneration by enhancing reactive gliosis and M¨¹ller glial activation, thereby impairing RGC survival. Mechanistically, cZNF609 functions as a ceRNA that sponges miR-615 to derepress METRN, supporting glial proliferation/activation."	0.7782
29932500	Thoracic cancer	2018	"hsa_circ_0000729, a potential prognostic biomarker in lung adenocarcinoma."	hsa_circ_0000792	circRNA_0000792			lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000792 is up-regulated in LUAD tissues (validated by qRT-PCR) and is proposed to act as a ceRNA by competitively binding miR-375, thereby affecting miR-375-associated target mRNAs. It shows diagnostic biomarker potential (ROC AUC ~0.815) and correlates with clinical parameters such as stage and distant metastasis."	0.5047
29932500	Thoracic cancer	2018	"hsa_circ_0000729, a potential prognostic biomarker in lung adenocarcinoma."	hsa_circ_0000729				lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	hsa_circ_0000729 is up-regulated in LUAD clinical tissues by qRT-PCR and is suggested to sponge miR-375 (negative association). It shows diagnostic biomarker potential with ROC AUC ~0.815.	0.459
29941867	Scientific reports	2018	Association of microRNA-7 and its binding partner CDR1-AS with the prognosis and prediction of 1st-line tamoxifen therapy in breast cancer.		ciRS-7 / CDR1as	hsa_circ_CDR1-AS	LINC00632	breast cancer 	MONDO:0007254	breast cancer	unknown	RT-qPCR	"This study quantified CDR1-AS (ciRS-7) in breast cancer cohorts and found it inversely correlated with hsa-miR-7, consistent with a miRNA-sponge relationship. Clinically, CDR1-AS was not prognostic or predictive for outcomes, and its expression appeared enriched in stromal components rather than tumor cells or TILs."	0.4758
29956720	International journal of molecular medicine	2018	Characteristics of circular RNA expression in lung tissues from mice with hypoxia_induced pulmonary hypertension.		mmu_circRNA_004592	mmu_circ_Fam120c	Fam120c	hypoxia-induced pulmonary hypertension 	MONDO:0005149	pulmonary hypertension	up-regulated	RT-qPCR; Microarray	"mmu_circRNA_004592 is significantly up-regulated in lung tissues from hypoxia-induced PH mice. The study predicts it acts as a ceRNA to sponge multiple miRNAs (e.g., mmu-miR-742-3p and mmu-miR-152-3p) and thereby increase miRNA-targeted gene expression, potentially contributing to vascular cell proliferation and reduced apoptosis."	0.4851
29956720	International journal of molecular medicine	2018	Characteristics of circular RNA expression in lung tissues from mice with hypoxia_induced pulmonary hypertension.		mmu_circRNA_018701	mmu_circ_Jmjd1c	Jmjd1c	hypoxia-induced pulmonary hypertension 	MONDO:0005149	pulmonary hypertension	up-regulated	RT-qPCR; Microarray	"mmu_circRNA_018701 is significantly up-regulated in lungs of hypoxia-induced PH mice and has predicted binding sites for five miRNAs, supporting a potential miRNA-sponge role. No downstream mRNA targets or functional experiments were reported for this circRNA."	0.4851
29956720	International journal of molecular medicine	2018	Characteristics of circular RNA expression in lung tissues from mice with hypoxia_induced pulmonary hypertension.		mmu_circRNA_010744	mmu_circ_Sntg1	Sntg1	hypoxia-induced pulmonary hypertension 	MONDO:0005149	pulmonary hypertension	up-regulated	RT-qPCR; Microarray	mmu_circRNA_010744 is significantly up-regulated in lungs of hypoxia-induced PH mice and has five predicted miRNA binding sites. The paper did not report a downstream ceRNA network or functional assays for this circRNA.	0.4851
29956720	International journal of molecular medicine	2018	Characteristics of circular RNA expression in lung tissues from mice with hypoxia_induced pulmonary hypertension.		mmu_circRNA_015666	mmu_circ_Ikbkap	Ikbkap	hypoxia-induced pulmonary hypertension 	MONDO:0005149	pulmonary hypertension	up-regulated	RT-qPCR; Microarray	mmu_circRNA_015666 is significantly up-regulated in lungs of hypoxia-induced PH mice and has predicted binding to five miRNAs. The study did not construct a ceRNA network or provide functional validation for this circRNA beyond expression and in-silico prediction.	0.4851
29956720	International journal of molecular medicine	2018	Characteristics of circular RNA expression in lung tissues from mice with hypoxia_induced pulmonary hypertension.		mmu_circRNA_016636	mmu_circ_Ttc7b	Ttc7b	hypoxia-induced pulmonary hypertension 	MONDO:0005149	pulmonary hypertension	up-regulated	RT-qPCR; Microarray	mmu_circRNA_016636 is significantly up-regulated in lungs of hypoxia-induced PH mice and has five predicted miRNA binding sites. No downstream targets or functional validation beyond expression and bioinformatic prediction were provided.	0.4851
29956720	International journal of molecular medicine	2018	Characteristics of circular RNA expression in lung tissues from mice with hypoxia_induced pulmonary hypertension.		mmu_circRNA_018351	mmu_circ_Zfhx3	Zfhx3	hypoxia-induced pulmonary hypertension 	MONDO:0005149	pulmonary hypertension	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_018351 is significantly down-regulated in lung tissues from hypoxia-induced PH mice. The study constructed a predicted circRNA-miRNA-mRNA network for it, consistent with a ceRNA mechanism, and hypothesized it may influence apoptosis-related responses via miR-207/miR-665."	0.4851
29956720	International journal of molecular medicine	2018	Characteristics of circular RNA expression in lung tissues from mice with hypoxia_induced pulmonary hypertension.		mmu_circRNA_008379	mmu_circ_Sp3	Sp3	hypoxia-induced pulmonary hypertension 	MONDO:0005149	pulmonary hypertension	down-regulated	RT-qPCR; Microarray	mmu_circRNA_008379 is significantly down-regulated in lungs of hypoxia-induced PH mice and has five predicted miRNA binding sites. The paper did not report a ceRNA network construction or functional assays for this circRNA beyond expression validation and bioinformatic prediction.	0.4851
29961269	Journal of cellular and molecular medicine	2018	Dysregulated circRNAs in plasma from active tuberculosis patients.		hsa_circ_091692	hsa_circ_CD99L2	CD99L2	active tuberculosis 	MONDO:0100481	active tuberculosis	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_091692 is up-regulated in plasma from active TB patients versus healthy controls and was validated by qRT-PCR after microarray screening. Predicted MRE analysis suggests potential binding to several miRNAs, but no downstream mechanism or clinical performance was established for this circRNA in this study."	0.4032
29961269	Journal of cellular and molecular medicine	2018	Dysregulated circRNAs in plasma from active tuberculosis patients.		hsa_circ_102296	hsa_circ_ANKRD12	ANKRD12	active tuberculosis 	MONDO:0100481	active tuberculosis	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_102296 is up-regulated in plasma from active TB patients versus healthy controls and was validated by qRT-PCR after microarray screening. It is reported to align with the host gene ANKRD12 and has predicted miRNA response elements, but no functional mechanism or clinical diagnostic analysis was reported for this circRNA."	0.4032
29961269	Journal of cellular and molecular medicine	2018	Dysregulated circRNAs in plasma from active tuberculosis patients.		hsa_circ_029965	hsa_circ_PDS5B	PDS5B	active tuberculosis 	MONDO:0100481	active tuberculosis	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_029965 is up-regulated in plasma from active TB patients versus healthy controls and was validated by qRT-PCR after microarray screening. It derives from host gene PDS5B and has predicted interacting miRNAs, but the study did not establish a specific pathway mechanism or clinical diagnostic value for this circRNA."	0.4032
29961269	Journal of cellular and molecular medicine	2018	Dysregulated circRNAs in plasma from active tuberculosis patients.		hsa_circ_103571	hsa_circ_LRCH3	LRCH3	active tuberculosis 	MONDO:0100481	active tuberculosis	down-regulated	RT-qPCR; Microarray	hsa_circRNA_103571 is down-regulated in plasma of active TB patients and shows diagnostic potential (AUC 0.838). The study predicts a ceRNA-like mechanism where hsa_circRNA_103571 targets TB-related miRNAs (including miR-29a and miR-16) and links to downstream mRNAs; GO/KEGG enrichment suggests association with processes such as autophagy and pathways such as Ras and regulation of actin cytoskeleton.	0.5047
29973643	Scientific reports	2018	Down-regulation of circPVRL3 promotes the proliferation and migration of gastric cancer cells.	hsa_circ_0066779	circPVRL3	hsa_circ_PVRL3	PVRL3	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"circPVRL3 is down-regulated in gastric cancer tissues and cell lines. Functionally, circPVRL3 acts as a tumor-suppressive circRNA: its knockdown increases proliferation and migration. Mechanistically, it is mainly cytoplasmic and is predicted to sponge multiple miRNAs and interact with RBPs, with additional predicted protein-coding potential."	0.8196
29983547	"Drug design, development and therapy"	2018	Computer-aided drug design and inhibitive effect of a novel nitrogenous heterocyclic compound and its mechanism on glioma U251 cells and breast cancer MCF-7 cells.		circUBAP2	hsa_circ_UBAP2	UBAP2	glioma 	MONDO:0021042	glioma	down-regulated	RT-qPCR	"In U251 glioma and MCF-7 breast cancer cells, the nitrogenous heterocyclic compound downregulated circUBAP2, which the authors describe as an oncogenic circRNA and associate with MAPK/ERK signaling in their pathway table."	0.4635
29983547	"Drug design, development and therapy"	2018	Computer-aided drug design and inhibitive effect of a novel nitrogenous heterocyclic compound and its mechanism on glioma U251 cells and breast cancer MCF-7 cells.		circZNF292	hsa_circ_ZNF292	ZNF292	glioma 	MONDO:0021042	glioma	down-regulated	RT-qPCR	circZNF292 was decreased in U251 and MCF-7 cells after treatment with the nitrogenous heterocyclic compound; it is presented as an oncogenic circRNA and is listed as involving Wnt/beta-catenin and JAK/STAT signaling in the paper¡¯s pathway table.	0.1768
29983547	"Drug design, development and therapy"	2018	Computer-aided drug design and inhibitive effect of a novel nitrogenous heterocyclic compound and its mechanism on glioma U251 cells and breast cancer MCF-7 cells.		circHIPK3	hsa_circ_HIPK3	HIPK3	glioma 	MONDO:0021042	glioma	down-regulated	RT-qPCR	circHIPK3 expression was decreased in U251 and MCF-7 cells after nitrogenous heterocyclic compound exposure; the paper links it to Wnt/beta-catenin signaling in a summary table but does not experimentally define a mechanism.	0.1768
29983547	"Drug design, development and therapy"	2018	Computer-aided drug design and inhibitive effect of a novel nitrogenous heterocyclic compound and its mechanism on glioma U251 cells and breast cancer MCF-7 cells.		circTCF25	hsa_circ_TCF25	TCF25	glioma 	MONDO:0021042	glioma	down-regulated	RT-qPCR	circTCF25 was downregulated in U251 and MCF-7 cells upon nitrogenous heterocyclic compound treatment; the paper associates it with PI3K/AKT signaling via a pathway table but provides no direct mechanistic validation.	0.1768
29983547	"Drug design, development and therapy"	2018	Computer-aided drug design and inhibitive effect of a novel nitrogenous heterocyclic compound and its mechanism on glioma U251 cells and breast cancer MCF-7 cells.		circCdr1 / Cdr1	hsa_circ_CDR1	CDR1	glioma 	MONDO:0021042	glioma	down-regulated	RT-qPCR	"circCdr1 was reduced in U251 and MCF-7 cells after nitrogenous heterocyclic compound treatment, reported as part of a panel of tumor-related circRNAs regulated by the compound; no specific downstream mechanism was tested for circCdr1."	0.1155
29983547	"Drug design, development and therapy"	2018	Computer-aided drug design and inhibitive effect of a novel nitrogenous heterocyclic compound and its mechanism on glioma U251 cells and breast cancer MCF-7 cells.		circZKSCAN1	hsa_circ_ZKSCAN1	ZKSCAN1	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR	circZKSCAN1 was upregulated in glioma U251 and breast cancer MCF-7 cells after drug treatment and is described by the authors as a tumor-suppressor circRNA; it is linked to PI3K/AKT signaling in their pathway table without direct mechanistic validation.	0.1768
29983547	"Drug design, development and therapy"	2018	Computer-aided drug design and inhibitive effect of a novel nitrogenous heterocyclic compound and its mechanism on glioma U251 cells and breast cancer MCF-7 cells.		circMTO1	hsa_circ_MTO1	MTO1	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR	circMTO1 was increased in U251 and MCF-7 cells after nitrogenous heterocyclic compound treatment and is described as a tumor-suppressor circRNA; it is linked to Wnt/beta-catenin and MAPK in the pathway table without mechanistic experiments specific to circMTO1.	0.1768
29983547	"Drug design, development and therapy"	2018	Computer-aided drug design and inhibitive effect of a novel nitrogenous heterocyclic compound and its mechanism on glioma U251 cells and breast cancer MCF-7 cells.		circITCH	hsa_circ_ITCH	ITCH	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR	circITCH was upregulated in U251 and MCF-7 cells after nitrogenous heterocyclic compound treatment and is described as a tumor suppressor; it is associated with Wnt/beta-catenin signaling in the pathway table without circITCH-specific mechanistic experiments.	0.1768
30018746	Oncotarget	2018	Circular RNA CpG island hypermethylation-associated silencing in human cancer.		circ104557	hsa_circ_TUSC3	TUSC3	human cancer 	MONDO:0004992	cancer	down-regulated	RT-qPCR; Microarray	TUSC3 circ104557 is epigenetically silenced (downregulated) in methylated HCT-116 cancer cells and reactivated in DNMT1/3B double-knockout cells. Its ectopic expression reduces hsa-miR-330-3p levels (miRNA decoy behavior) and inhibits xenograft tumor growth.	0.6212
30018746	Oncotarget	2018	Circular RNA CpG island hypermethylation-associated silencing in human cancer.		circ100686	hsa_circ_ATRNL1	ATRNL1	human cancer 	MONDO:0004992	cancer	down-regulated	RT-qPCR; Microarray	"ATRNL1 circ100686 is downregulated in methylated HCT-116 cancer cells and reactivated in DNMT-deficient DKO cells. Its silencing/reactivation correlates inversely with its complementary miRNA hsa-miR-378a-3p, supporting a miRNA-decoy role."	0.5193
30018746	Oncotarget	2018	Circular RNA CpG island hypermethylation-associated silencing in human cancer.		circ104948	hsa_circ_POMT1	POMT1	human cancer 	MONDO:0004992	cancer	down-regulated	RT-qPCR; Microarray	"POMT1 circ104948 is silenced (downregulated) in methylated HCT-116 cancer cells together with its host gene transcripts and is re-expressed in DNMT-deficient DKO cells, consistent with promoter CpG island hypermethylation-associated transcriptional silencing."	0.5193
30018746	Oncotarget	2018	Circular RNA CpG island hypermethylation-associated silencing in human cancer.		circ104949	hsa_circ_POMT1	POMT1	human cancer 	MONDO:0004992	cancer	down-regulated	RT-qPCR; Microarray	"POMT1 circ104949 is downregulated in methylated HCT-116 cancer cells and restored in DNMT-deficient DKO cells, consistent with CpG island hypermethylation-associated silencing of its host locus."	0.5193
30018746	Oncotarget	2018	Circular RNA CpG island hypermethylation-associated silencing in human cancer.		circ101356	hsa_circ_SAMD4A	SAMD4A	human cancer 	MONDO:0004992	cancer	down-regulated	RT-qPCR; Microarray	"SAMD4A circ101356 is downregulated in methylated HCT-116 cancer cells and reactivated in DNMT-deficient DKO cells. Its reactivation is associated with reduced levels of complementary miRNAs (hsa-miR-330-3p and hsa-miR-660-5p), supporting a miRNA-decoy mechanism."	0.5193
30022841	OncoTargets and therapy	2018	Overexpressed CDR1as functions as an oncogene to promote the tumor progression via miR-7 in non-small-cell lung cancer.		CDR1as / ciRS-7	hsa_circ_CDR1		non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"CDR1as is up-regulated in NSCLC and acts as an oncogenic circRNA. It sponges miR-7, thereby up-regulating miR-7 targets (EGFR, CCNE1, PIK3CD) to promote proliferation/cell growth and inhibit apoptosis, and its high expression predicts poorer overall survival."	0.7408
30053867	Journal of experimental & clinical cancer research : CR	2018	circFBLIM1 act as a ceRNA to promote hepatocellular cancer progression by sponging miR-346.	hsa_circ_0010090	circFBLIM1	hsa_circ_FBLIM1	FBLIM1	hepatocellular cancer 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circFBLIM1 is up-regulated in HCC tissues and cell lines and promotes malignant phenotypes. Mechanistically, it acts as a cytoplasmic ceRNA that sponges miR-346, thereby regulating FBLIM1 expression and supporting HCC growth and invasion in vitro and in xenograft/metastasis models."	0.7893
30061181	Bioscience reports	2018	Hsa_circ_0000673 is down-regulated in gastric cancer and inhibits the proliferation and invasion of tumor cells by targetting miR-532-5p.	hsa_circ_0000673		hsa_circ_RSL1D1	RSL1D1	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0000673 is down-regulated in gastric cancer tissues, cell lines, and plasma, and its lower expression correlates with higher GC stage. Functionally, it suppresses GC cell proliferation, colony formation, invasion, and xenograft tumor growth by sponging miR-532-5p and thereby increasing RUNX3 (and downstream p21, Bim, E-cadherin) expression."	0.6829
30064461	Journal of experimental & clinical cancer research : CR	2018	Circular RNA IARS (circ-IARS) secreted by pancreatic cancer cells and located within exosomes regulates endothelial monolayer permeability to promote tumor metastasis.			hsa_circ_IARS	IARS	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; Microarray	"In PDAC, circ-IARS is up-regulated in tumor tissues and in plasma exosomes, and higher levels are linked to metastatic features and shorter postoperative survival. Exosomal circ-IARS enters HUVECs and sponges miR-122 to de-repress RhoA, increasing RhoA activity, lowering ZO-1, raising F-actin, and thereby enhancing endothelial permeability to facilitate invasion and metastasis."	0.5997
30066828	International journal of molecular medicine	2018	Screening of circular RNAs and validation of circANKRD36 associated with inflammation in patients with type 2 diabetes mellitus.		circANKRD36	hsa_circ_ANKRD36	ANKRD36	type 2 diabetes mellitus 	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RT-qPCR; RNA-seq	"This study identified and validated circANKRD36 as significantly up-regulated in peripheral blood leukocytes of T2DM patients. Its expression correlates with glycemic indicators and inflammatory cytokines (notably IL-6), and bioinformatic predictions suggest circANKRD36 may participate in inflammation-related pathways through interactions with multiple miRNAs and possible cis-regulation of its host gene ANKRD36, indicating biomarker potential for chronic inflammation in T2DM."	0.6193
30066828	International journal of molecular medicine	2018	Screening of circular RNAs and validation of circANKRD36 associated with inflammation in patients with type 2 diabetes mellitus.	hsa_circ_0008922				type 2 diabetes mellitus 	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0008922 was among the circRNAs validated by RT-qPCR as up-regulated in T2DM peripheral blood cells in the initial verification step, but it was not further mechanistically characterized in this study."	0.1904
30066828	International journal of molecular medicine	2018	Screening of circular RNAs and validation of circANKRD36 associated with inflammation in patients with type 2 diabetes mellitus.	hsa_circ_0009035				type 2 diabetes mellitus 	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0009035 was among the circRNAs validated by RT-qPCR as up-regulated in T2DM peripheral blood cells in the initial verification step, but it was not further mechanistically characterized in this study."	0.1904
30066847	International journal of oncology	2018	Competing endogenous RNA analysis reveals the regulatory potency of circRNA_036186 in HNSCC.	hsa_circ_0036186	circRNA_036186			head and neck squamous cell carcinoma 	MONDO:0010150	head and neck squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circRNA_036186 is upregulated in HNSCC tissues and is proposed to act as a ceRNA/miRNA sponge for miR-193b-3p, thereby positively regulating 14-3-3zeta and implicating Hippo signaling pathway involvement in HNSCC progression. The authors suggest it may have diagnostic/therapeutic biomarker potential, although functional validation is limited."	0.5135
30068360	Journal of translational medicine	2018	Regulatory network of circRNA-miRNA-mRNA contributes to the histological classification and disease progression in gastric cancer.	hsa_circ_0000284		hsa_circ_HIPK3	HIPK3	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in gastric cancer and correlates with aggressive clinicopathological features (T stage and Ming¡¯s classification). Functionally, it promotes GC cell proliferation and is linked to a circHIPK3_miR-124/miR-29b regulatory network affecting downstream targets such as COL1A1, COL4A1 and CDK6."	0.6102
30069275	Disease markers	2018	Clinical Significance of the Decreased Expression of hsa_circ_001242 in Oral Squamous Cell Carcinoma.		hsa_circ_001242	hsa_circ_TRDMT1	TRDMT1	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR	"hsa_circ_001242 is significantly down-regulated in OSCC tissues and OSCC cell lines. Lower expression correlates with larger tumor size and higher T stage, and it shows diagnostic potential for distinguishing OSCC from adjacent normal tissues (AUC 0.784)."	0.4187
30072869	Frontiers in molecular neuroscience	2018	NFIX Circular RNA Promotes Glioma Progression by Regulating miR-34a-5p via Notch Signaling Pathway.			hsa_circ_NFIX	NFIX	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; RNA-seq	"circNFIX is up-regulated in glioma tissues/cell lines and promotes glioma growth and motility. Mechanistically, circNFIX sponges miR-34a-5p to de-repress NOTCH1, activating Notch signaling and thereby enhancing proliferation/migration while reducing apoptosis; knockdown of circNFIX suppresses xenograft tumor growth."	0.73
30080890	PLoS pathogens	2018	The Epstein Barr virus circRNAome.		circEBNA_W1_C1	ebv_circ_EBNA	EBNA	Burkitt¡¯s lymphoma	MONDO:0007243	Burkitt lymphoma	unknown	RT-qPCR; RNA-seq	"circEBNA_W1_C1 is an EBV circRNA expressed from the Cp latency promoter via W1-to-C1 backsplicing, detected mainly in type III latency cell models and enriched in the nucleus. The paper suggests it may contribute to type III latency-specific regulatory processes (e.g., Cp-driven transcript diversity or Cp promoter regulation), but no definitive mechanism is established."	0.5246
30080890	PLoS pathogens	2018	The Epstein Barr virus circRNAome.		circEBNA_W2_C1	ebv_circ_EBNA	EBNA	Burkitt¡¯s lymphoma	MONDO:0007243	Burkitt lymphoma	unknown	RT-qPCR; RNA-seq	"circEBNA_W2_C1 is an EBV circRNA produced by W2-to-C1 backsplicing from the Cp latency promoter, detected primarily in type III latency models and enriched in the nucleus. The paper proposes potential type III latency-specific regulatory roles but does not experimentally establish a specific mechanism."	0.5246
30080890	PLoS pathogens	2018	The Epstein Barr virus circRNAome.		circRPMS1_E4_E3a	ebv_circ_RPMS1	RPMS1	Burkitt¡¯s lymphoma	MONDO:0007243	Burkitt lymphoma	unknown	RT-qPCR; RNA-seq	"circRPMS1_E4_E3a is an EBV RPMS1-locus circRNA expressed across latency types and detectable in EBV-positive stomach cancer biopsies. It is predominantly nuclear with possible low cytoplasmic localization; the study suggests it could affect miRNA processing due to its splice-acceptor context, but its function in tumors remains unproven."	0.6235
30080890	PLoS pathogens	2018	The Epstein Barr virus circRNAome.		circRPMS1_E4_E2	ebv_circ_RPMS1	RPMS1	Burkitt¡¯s lymphoma	MONDO:0007243	Burkitt lymphoma	unknown	RT-qPCR; RNA-seq	circRPMS1_E4_E2 is an EBV RPMS1-locus circRNA expressed across latency types and detectable in EBV-positive stomach cancer biopsies. The study validates its circularity by RNase R resistance and junction sequencing but does not report a specific mechanism or subcellular localization for this circRNA.	0.606
30080890	PLoS pathogens	2018	The Epstein Barr virus circRNAome.		circLMP2_E8_E2	ebv_circ_LMP2	LMP2	Burkitt¡¯s lymphoma	MONDO:0007243	Burkitt lymphoma	unknown	RT-qPCR; RNA-seq	"circLMP2_E8_E2 is an EBV reactivation-associated circRNA formed by exon 8-to-exon 2 backsplicing at the LMP2 locus, with context-specific expression in reactivation models. It shows low but significant cytoplasmic localization and its structure likely includes the coding region of LMP2B, raising the possibility it represents a novel circular isoform; no miRNA sponge evidence was found for LMP2 exons 2_8."	0.5246
30080890	PLoS pathogens	2018	The Epstein Barr virus circRNAome.		circBHLF1 / circBHLF1alt / circBHLF1-alt	ebv_circ_BHLF1	BHLF1	Burkitt¡¯s lymphoma	MONDO:0007243	Burkitt lymphoma	unknown	RT-qPCR; RNA-seq	"circBHLF1 (and the closely related circBHLF1alt isoform) is a highly abundant EBV lytic circRNA during reactivation, RNase R-resistant, and predominantly nuclear by RT-qPCR and BaseScope. The paper discusses a plausible role in lytic DNA replication due to proximity to oriLyt, but this remains speculative without direct functional assays."	0.5337
30080890	PLoS pathogens	2018	The Epstein Barr virus circRNAome.		circEBNA_W1_C1	ebv_circ_EBNA	EBNA	stomach cancer 	MONDO:0001056	gastric cancer	unknown	RT-qPCR; RNA-seq	"circEBNA_W1_C1 is an EBV circRNA expressed from the Cp latency promoter via W1-to-C1 backsplicing, detected mainly in type III latency cell models and enriched in the nucleus. The paper suggests it may contribute to type III latency-specific regulatory processes (e.g., Cp-driven transcript diversity or Cp promoter regulation), but no definitive mechanism is established."	0.5246
30080890	PLoS pathogens	2018	The Epstein Barr virus circRNAome.		circEBNA_W2_C1	ebv_circ_EBNA	EBNA	stomach cancer 	MONDO:0001056	gastric cancer	unknown	RT-qPCR; RNA-seq	"circEBNA_W2_C1 is an EBV circRNA produced by W2-to-C1 backsplicing from the Cp latency promoter, detected primarily in type III latency models and enriched in the nucleus. The paper proposes potential type III latency-specific regulatory roles but does not experimentally establish a specific mechanism."	0.5246
30080890	PLoS pathogens	2018	The Epstein Barr virus circRNAome.		circRPMS1_E4_E3a	ebv_circ_RPMS1	RPMS1	stomach cancer 	MONDO:0001056	gastric cancer	unknown	RT-qPCR; RNA-seq	"circRPMS1_E4_E3a is an EBV RPMS1-locus circRNA expressed across latency types and detectable in EBV-positive stomach cancer biopsies. It is predominantly nuclear with possible low cytoplasmic localization; the study suggests it could affect miRNA processing due to its splice-acceptor context, but its function in tumors remains unproven."	0.6235
30080890	PLoS pathogens	2018	The Epstein Barr virus circRNAome.		circRPMS1_E4_E2	ebv_circ_RPMS1	RPMS1	stomach cancer 	MONDO:0001056	gastric cancer	unknown	RT-qPCR; RNA-seq	circRPMS1_E4_E2 is an EBV RPMS1-locus circRNA expressed across latency types and detectable in EBV-positive stomach cancer biopsies. The study validates its circularity by RNase R resistance and junction sequencing but does not report a specific mechanism or subcellular localization for this circRNA.	0.606
30080890	PLoS pathogens	2018	The Epstein Barr virus circRNAome.		circLMP2_E8_E2	ebv_circ_LMP2	LMP2	stomach cancer 	MONDO:0001056	gastric cancer	unknown	RT-qPCR; RNA-seq	"circLMP2_E8_E2 is an EBV reactivation-associated circRNA formed by exon 8-to-exon 2 backsplicing at the LMP2 locus, with context-specific expression in reactivation models. It shows low but significant cytoplasmic localization and its structure likely includes the coding region of LMP2B, raising the possibility it represents a novel circular isoform; no miRNA sponge evidence was found for LMP2 exons 2_8."	0.5246
30080890	PLoS pathogens	2018	The Epstein Barr virus circRNAome.			ebv_circ_BHLF1	BHLF1	stomach cancer 	MONDO:0001056	gastric cancer	unknown	RT-qPCR; RNA-seq	"circBHLF1 (and the closely related circBHLF1alt isoform) is a highly abundant EBV lytic circRNA during reactivation, RNase R-resistant, and predominantly nuclear by RT-qPCR and BaseScope. The paper discusses a plausible role in lytic DNA replication due to proximity to oriLyt, but this remains speculative without direct functional assays."	0.5337
30082829	Cell death & disease	2018	CiRS-7 promotes growth and metastasis of esophageal squamous cell carcinoma via regulation of miR-7/HOXB13.		Cdr1as / ciRS-7	hsa_circ_CDR1AS		esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"ciRS-7 (Cdr1as) is up-regulated in ESCC tissues and cell lines and its high expression is associated with worse OS/DFS. Functionally, ciRS-7 promotes ESCC malignant progression by sponging miR-7, thereby de-repressing HOXB13 and activating the HOXB13-mediated NF-kappaB/p65 (p65 phosphorylation) pathway, enhancing proliferation and metastasis."	0.7344
30083277	Theranostics	2018	circEPSTI1 as a Prognostic Marker and Mediator of Triple-Negative Breast Cancer Progression.		hsa_ circRNA_000479	hsa_circ_EPSTI1	EPSTI1	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circEPSTI1 is up-regulated in TNBC tissues/cell lines and promotes proliferation and tumor growth while inhibiting apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-4753 and miR-6809 to increase BCL11A expression. High circEPSTI1 expression is associated with worse DFS/OS and serves as an independent prognostic marker in TNBC."	0.8601
30086127	Medical science monitor : international medical journal of experimental and clinical research	2018	Upregulated hsa_circ_0004458 Contributes to Progression of Papillary Thyroid Carcinoma by Inhibition of miR-885-5p and Activation of RAC1.	hsa_circ_0004458	circ_0004458	hsa_circ_PSD3	PSD3	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"In papillary thyroid carcinoma, hsa_circ_0004458 is up-regulated and promotes tumor cell proliferation and in vivo tumor growth while inhibiting cell cycle arrest and apoptosis. Mechanistically, it acts as a ceRNA that sponges miR-885-5p, thereby relieving repression of RAC1 and activating RAC1 expression."	0.7256
30087579	Cancer management and research	2018	Profiles of differentially expressed circRNAs in esophageal and breast cancer.		hsa_circRNA_103670	hsa_circ_CNOT6L	CNOT6L	esophageal squamous cell cancer 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	Microarray	"In ESCC tumor tissues, hsa_circRNA_103670 is identified by circRNA microarray as strongly up-regulated compared with adjacent normal-appearing esophagus tissues. It is reported to align with/derive from the host gene CNOT6L, suggesting a potential link to gene expression regulation, but no functional mechanism was experimentally validated in this study."	0.1155
30087579	Cancer management and research	2018	Profiles of differentially expressed circRNAs in esophageal and breast cancer.		hsa_circRNA_030162	hsa_circ_TPT1	TPT1	esophageal squamous cell cancer 	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	Microarray	"In ESCC tumor tissues, hsa_circRNA_030162 is identified by circRNA microarray as strongly down-regulated compared with adjacent normal-appearing esophagus tissues. It is reported to derive from the host gene TPT1, but the study did not experimentally validate downstream functions or mechanisms for this circRNA."	0.1155
30087579	Cancer management and research	2018	Profiles of differentially expressed circRNAs in esophageal and breast cancer.		hsa_circRNA_005230	hsa_circ_DNM3OS	DNM3OS	breast cancer 	MONDO:0007254	breast cancer	up-regulated	Microarray	"In breast cancer tissues, hsa_circRNA_005230 is identified by circRNA microarray as markedly up-regulated versus adjacent normal-appearing tissues. It is reported to be spliced from the host gene DNM3OS, which is involved in the formation of miR-199a2 and miR-214, but no direct functional mechanism of this circRNA was experimentally validated in this study."	0.1155
30087579	Cancer management and research	2018	Profiles of differentially expressed circRNAs in esophageal and breast cancer.		hsa_circRNA_406225	hsa_circ_TAMM41	TAMM41	breast cancer 	MONDO:0007254	breast cancer	down-regulated	Microarray	"In breast cancer tissues, hsa_circRNA_406225 is identified by circRNA microarray as markedly down-regulated versus adjacent normal-appearing tissues. It is reported to align with the host gene TAMM41, but the study did not experimentally validate any downstream function or mechanism for this circRNA."	0.1155
30089772	Experimental & molecular medicine	2018	CircularRNA_104670 plays a critical role in intervertebral disc degeneration by functioning as a ceRNA.		CircRNA_104670			intervertebral disc degeneration 	MONDO:0011385	intervertebral disk degenerative disorder	up-regulated	RT-qPCR; Microarray	"circRNA_104670 is up-regulated in human degenerative nucleus pulposus tissues and serves as a ceRNA that sponges miR-17-3p, thereby derepressing MMP-2. Functionally, it promotes NP cell apoptosis, reduces proliferation, enhances ECM degradation, and accelerates IDD progression, with diagnostic potential (high AUC and correlation with Pfirrmann grade)."	0.7369
30092792	Journal of translational medicine	2018	A circRNA-miRNA-mRNA network identification for exploring underlying pathogenesis and therapy strategy of hepatocellular carcinoma.	hsa_circ_0004913	hsa_circRNA_102166	hsa_circ_TEX2	TEX2	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_102166 (hsa_circ_0004913, TEX2) is down-regulated in HCC tissues and was validated in 16 paired clinical samples by RT-qPCR, with back-splice junction confirmed by Sanger sequencing."	0.4773
30092792	Journal of translational medicine	2018	A circRNA-miRNA-mRNA network identification for exploring underlying pathogenesis and therapy strategy of hepatocellular carcinoma.	hsa_circ_0000098	hsa_circRNA_100291	hsa_circ_SLC30A7	SLC30A7	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_100291 (hsa_circ_0000098, SLC30A7) is down-regulated in HCC (microarray) and shows a down-regulated tendency by RT-qPCR. Bioinformatic predictions suggest it may act as a ceRNA sponging miR-583/miR-1276 to regulate hub genes such as ESR1, JUN, AR and FOXO1."	0.5135
30092792	Journal of translational medicine	2018	A circRNA-miRNA-mRNA network identification for exploring underlying pathogenesis and therapy strategy of hepatocellular carcinoma.	hsa_circ_0002980	hsa_circRNA_104515	hsa_circ_AGK	AGK	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_104515 (hsa_circ_0002980, AGK) is down-regulated in HCC (microarray) and shows a down-regulated tendency by RT-qPCR. Bioinformatic analysis suggests it may act as a ceRNA sponging miR-1303/miR-142-5p/miR-877-5p to regulate hub genes such as AR, MYCN, IGF1 and CD34."	0.5135
30092792	Journal of translational medicine	2018	A circRNA-miRNA-mRNA network identification for exploring underlying pathogenesis and therapy strategy of hepatocellular carcinoma.	hsa_circ_0067934	hsa_circRNA_103510	hsa_circ_PRKCI	PRKCI	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	Microarray	"hsa_circRNA_103510 (hsa_circ_0067934, PRKCI) was identified as up-regulated in HCC by GEO circRNA microarray meta-analysis, but was not detectable in the authors' in-house clinical samples, so it was not pursued for mechanistic analyses."	0.1155
30092792	Journal of translational medicine	2018	A circRNA-miRNA-mRNA network identification for exploring underlying pathogenesis and therapy strategy of hepatocellular carcinoma.	hsa_circ_0017639	hsa_circRNA_100542	hsa_circ_SFMBT2	SFMBT2	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	Microarray	"hsa_circRNA_100542 (hsa_circ_0017639, SFMBT2) was identified as up-regulated in HCC by GEO circRNA microarray meta-analysis, but was not detectable in the authors' in-house clinical samples and was not included in downstream network analyses."	0.1155
30098504	Molecular therapy. Nucleic acids	2018	Silencing of circRNA.2837 Plays a Protective Role in Sciatic Nerve Injury by Sponging the miR-34 Family via Regulating Neuronal Autophagy.		circRNA.2837	rno_circ_Slc25a16	Slc25a16	sciatic nerve injury 	MONDO:0100634		down-regulated	RT-qPCR; RNA-seq	"In rat sciatic nerve injury, circRNA.2837 is significantly down-regulated. Its knockdown promotes neuronal autophagy (LC3-II up, p62 down) and alleviates injury in vivo. Mechanistically, circRNA.2837 acts as a sponge for the miR-34 family (miR-34a/34b/34c), with miR-34a mediating the autophagy-related effects."	0.6722
30103209	Aging	2018	Circ-BPTF promotes bladder cancer progression and recurrence through the miR-31-5p/RAB27A axis.	hsa_circ_0000799		hsa_circ_BPTF	BPTF	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	circ-BPTF (hsa_circ_0000799) is up-regulated in bladder cancer tissues/cell lines and is associated with recurrence and poor overall survival. It promotes BCa proliferation and motility and acts as a ceRNA by sponging miR-31-5p to increase RAB27A expression; knockdown suppresses tumor growth in a xenograft model.	0.8814
30111766	Medical science monitor : international medical journal of experimental and clinical research	2018	Circular RNA Complement Factor H (CFH) Promotes Glioma Progression by Sponging miR-149 and Regulating AKT1.	hsa_circ_0015758		hsa_circ_CFH	CFH	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ-CFH (has_circ_0015758) is up-regulated in glioma tissues and glioma cell lines and promotes glioma growth. It acts as a miR-149 sponge to derepress AKT1, enhancing proliferative capacity in vitro and tumor growth in xenografts."	0.6916
30123094	Cancer cell international	2018	Circ-ZEB1.33 promotes the proliferation of human HCC by sponging miR-200a-3p and upregulating CDK6.			hsa_circ_ZEB1	ZEB1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ-ZEB1.33 is up-regulated in HCC tumor tissue and patient serum, promotes HCC cell proliferation and S-phase entry. Mechanistically, it sponges miR-200a-3p to de-repress CDK6 (and downstream Rb phosphorylation), and higher circ-ZEB1.33 is associated with advanced TMN stage and worse survival, supporting biomarker potential."	0.7853
30123704	PeerJ	2018	Profile and clinical implication of circular RNAs in human papillary thyroid carcinoma.		hsa_circRNA_007148	hsa_circ_FNDC3B	FNDC3B	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_007148 is up-regulated in PTC tissues and its higher expression is associated with lymph node metastasis. It shows diagnostic potential for distinguishing PTC from adjacent normal thyroid tissues, and was analyzed in a predicted circRNA-miRNA-mRNA network."	0.6556
30123704	PeerJ	2018	Profile and clinical implication of circular RNAs in human papillary thyroid carcinoma.		hsa_circRNA_047771	hsa_circ_NARS	NARS	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_047771 is down-regulated in PTC tissues and lower levels are associated with BRAFV600 mutation, lymph node metastasis, and advanced TNM stage. The study predicts a circRNA-miRNA-mRNA network involving this circRNA, including miR-522-3p and miR-153-5p, and supports its diagnostic potential by ROC analysis."	0.6556
30127310	International journal of molecular sciences	2018	ceRNA Cross-Talk in Paulownia Witches' Broom Disease.		circRNA200		AIP	Paulownia witches¡¯ broom (PaWB) disease 	Plant diseases		dysregulated	RNA-seq	"circRNA200 was identified as a candidate PaWB-related circRNA in infected vs healthy Paulownia fortunei, and it originates from the AIP host gene. The study implicates this circRNA in PaWB-associated regulatory changes, but does not report a specific miRNA/mRNA axis or functional assays for circRNA200."	0.1155
30127310	International journal of molecular sciences	2018	ceRNA Cross-Talk in Paulownia Witches' Broom Disease.		circRNA362		AIP	Paulownia witches¡¯ broom (PaWB) disease 	Plant diseases		dysregulated	RNA-seq	"circRNA362 was identified as a candidate PaWB-related circRNA in infected vs healthy Paulownia fortunei, and it originates from the AIP host gene. The paper does not provide a specific validated ceRNA axis or functional experiments for circRNA362."	0.1155
30127310	International journal of molecular sciences	2018	ceRNA Cross-Talk in Paulownia Witches' Broom Disease.		circRNA137		OPR	Paulownia witches¡¯ broom (PaWB) disease 	Plant diseases		dysregulated	RNA-seq	"circRNA137 was nominated as a candidate PaWB-related circRNA and is derived from the OPR host gene, which is involved in jasmonic acid biosynthesis-related defense pathways. No direct functional mechanism (e.g., specific miRNA targets) was validated for circRNA137 in this paper."	0.1155
30127310	International journal of molecular sciences	2018	ceRNA Cross-Talk in Paulownia Witches' Broom Disease.		circRNA962		PP2C	Paulownia witches¡¯ broom (PaWB) disease 	Plant diseases		dysregulated	RNA-seq	"circRNA962 was identified as a candidate PaWB-related circRNA and derives from the PP2C host gene, which is implicated in plant signal transduction. The paper does not present a validated downstream miRNA/mRNA regulatory axis or functional assays specifically for circRNA962."	0.1155
30127310	International journal of molecular sciences	2018	ceRNA Cross-Talk in Paulownia Witches' Broom Disease.		circRNA104		CAD	Paulownia witches¡¯ broom (PaWB) disease 	Plant diseases		dysregulated	RNA-seq	circRNA104 was considered a candidate PaWB-related circRNA and is produced from the CAD host gene associated with lignin biosynthesis. The study does not provide specific interaction partners or functional validation for circRNA104 beyond differential expression/host-gene context.	0.1155
30127310	International journal of molecular sciences	2018	ceRNA Cross-Talk in Paulownia Witches' Broom Disease.		circRNA1225		ACSL	Paulownia witches¡¯ broom (PaWB) disease 	Plant diseases		dysregulated	RNA-seq	circRNA1225 was identified as a candidate PaWB-related circRNA and is derived from the ACSL host gene linked to fatty acid metabolism. The paper does not report validated ceRNA interactions or direct functional assays for circRNA1225.	0.1155
30127310	International journal of molecular sciences	2018	ceRNA Cross-Talk in Paulownia Witches' Broom Disease.		circRNA770		Ses	Paulownia witches¡¯ broom (PaWB) disease 	Plant diseases		dysregulated	RNA-seq	circRNA770 was considered a candidate PaWB-related circRNA and originates from the Ses host gene (secologanin synthase-like). The study does not present validated miRNA interactions or functional experiments specific to circRNA770.	0.1155
30127310	International journal of molecular sciences	2018	ceRNA Cross-Talk in Paulownia Witches' Broom Disease.		circRNA337		gpx	Paulownia witches¡¯ broom (PaWB) disease 	Plant diseases		dysregulated	RNA-seq	circRNA337 was identified as a candidate PaWB-related circRNA and derives from the gpx host gene involved in oxidative stress/ROS scavenging. The paper does not experimentally validate a circRNA337-centered ceRNA mechanism or functional phenotype.	0.1155
30127310	International journal of molecular sciences	2018	ceRNA Cross-Talk in Paulownia Witches' Broom Disease.		circRNA345		CAO	Paulownia witches¡¯ broom (PaWB) disease 	Plant diseases		dysregulated	RNA-seq	circRNA345 was considered a candidate PaWB-related circRNA and is derived from the CAO host gene involved in porphyrin and chlorophyll metabolism. The study does not report specific validated miRNA/mRNA interactions or functional assays for circRNA345.	0.1155
30134837	"Molecular medicine (Cambridge, Mass.)"	2018	Circular RNA CEP128 acts as a sponge of miR-145-5p in promoting the bladder cancer progression via regulating SOX11.	hsa_circ_0102722		hsa_circ_CEP128	CEP128	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"circCEP128 is up-regulated in bladder cancer and mainly localizes to the cytoplasm. It promotes proliferation and inhibits apoptosis by acting as a ceRNA sponge for miR-145-5p, thereby increasing SOX11 expression; circCEP128 knockdown induces G1/S arrest and apoptosis in bladder cancer cells."	0.7859
30136305	Journal of cellular biochemistry	2018	MiR-145 affected the circular RNA expression in prostate cancer LNCaP cells.		hsa_circRNA_101981	hsa_circ_MAP2K4	MAP2K4	prostate cancer 	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; Microarray	hsa_circRNA_101981 (host gene MAP2K4) is down-regulated in prostate cancer tissue but up-regulated upon miR-145 overexpression in LNCaP cells. Its interaction with hsa-miR-145-5p was supported by bioinformatic prediction and confirmed by dual-luciferase reporter assay.	0.5922
30136305	Journal of cellular biochemistry	2018	MiR-145 affected the circular RNA expression in prostate cancer LNCaP cells.		hsa_circRNA_008068	hsa_circ_KATNAL1	KATNAL1	prostate cancer 	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; Microarray	hsa_circRNA_008068 (host gene KATNAL1) is down-regulated in prostate cancer tissue and is induced by miR-145 overexpression in LNCaP cells. It directly interacts with hsa-miR-145-3p as validated by luciferase reporter assay.	0.5922
30136305	Journal of cellular biochemistry	2018	MiR-145 affected the circular RNA expression in prostate cancer LNCaP cells.		hsa_circRNA_406557	hsa_circ_RAPGEF2	RAPGEF2	prostate cancer 	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; Microarray	hsa_circRNA_406557 (host gene RAPGEF2) is down-regulated in prostate cancer tissue and increases when miR-145 is overexpressed in LNCaP cells. It binds hsa-miR-145-3p and this interaction was validated by luciferase assay.	0.5922
30136305	Journal of cellular biochemistry	2018	MiR-145 affected the circular RNA expression in prostate cancer LNCaP cells.		hsa_circRNA_101996	hsa_circ_SPECC1	SPECC1	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	hsa_circRNA_101996 (host gene SPECC1) is up-regulated in prostate cancer tissue but is reduced after miR-145 overexpression in LNCaP cells. It interacts with hsa-miR-145-5p based on prediction and luciferase validation.	0.5922
30136305	Journal of cellular biochemistry	2018	MiR-145 affected the circular RNA expression in prostate cancer LNCaP cells.		hsa_circRNA_091420	hsa_circ_RPL39	RPL39	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	hsa_circRNA_091420 (host gene RPL39) is up-regulated in prostate cancer tissue and is suppressed by miR-145 overexpression in LNCaP cells. It binds hsa-miR-145-5p as shown by luciferase reporter assays.	0.5922
30147374	Cancer management and research	2018	The expression profile and clinical application potential of hsa_circ_0000711 in colorectal cancer.	hsa_circ_0000711		hsa_circ_NFATC3	NFATC3	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"hsa_circ_0000711 is significantly down-regulated in CRC tissues and CRC cell lines. Lower hsa_circ_0000711 expression is associated with poorer overall survival and may serve as an independent prognostic factor, and it shows diagnostic potential (AUC 0.81) for CRC."	0.6355
30150410	Proceedings of the National Academy of Sciences of the United States of America	2018	Circular DNA tumor viruses make circular RNAs.		circBART		BART	posttransplant lymphoproliferative disease 	MONDO:0019088	post-transplant lymphoproliferative disease	unknown	RT-qPCR; RNA-seq	"EBV circBARTs are stable viral circRNAs produced from the BART locus and broadly detected across EBV-associated tumors and latency types. Intron-retaining isoforms are mainly nuclear, whereas exon-only isoforms are present in both nucleus and cytoplasm; they are proposed as potential biomarkers and may contribute to EBV tumor biology, though specific mechanisms were not established."	0.606
30150410	Proceedings of the National Academy of Sciences of the United States of America	2018	Circular DNA tumor viruses make circular RNAs.		circvIRF4		vIRF4	primary effusion lymphoma 	MONDO:0018842	primary effusion lymphoma	unknown	RT-qPCR; RNA-seq	"KSHV circvIRF4 is a constitutively expressed, RNase R-resistant viral circRNA from the vIRF4 locus in PEL cell lines and detectable in a subset of KS/MCD tissues. It is distributed in both nucleus and cytoplasm and was not found in polysome fractions; functional roles in oncogenesis were not directly demonstrated."	0.606
30150410	Proceedings of the National Academy of Sciences of the United States of America	2018	Circular DNA tumor viruses make circular RNAs.		circPAN		PAN	primary effusion lymphoma 	MONDO:0018842	primary effusion lymphoma	unknown	RT-qPCR; RNA-seq	"KSHV PAN locus produces numerous low-abundance, variable circRNAs (including antisense K7.3-derived species) via a proposed hyperbacksplicing mechanism, with levels increasing upon lytic reactivation. These circPAN/K7.3 RNAs are detected in KSHV-associated tumors and localize to both nucleus and cytoplasm, but their specific oncogenic functions were not defined."	0.5909
30153287	PloS one	2018	"Circular RNAs hsa_circ_0032462, hsa_circ_0028173, hsa_circ_0005909 are predicted to promote CADM1 expression by functioning as miRNAs sponge in human osteosarcoma."	hsa_circ_0032462				osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0032462 is up-regulated in osteosarcoma cell lines and is predicted to act as a ceRNA by sponging has-miR-338-3p, thereby increasing CADM1 expression and promoting osteosarcoma development."	0.3213
30153287	PloS one	2018	"Circular RNAs hsa_circ_0032462, hsa_circ_0028173, hsa_circ_0005909 are predicted to promote CADM1 expression by functioning as miRNAs sponge in human osteosarcoma."	hsa_circ_0028173				osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	hsa_circ_0028173 is up-regulated in osteosarcoma cell lines and is predicted to sponge has-miR-142-5p and has-miR-338-3p to increase CADM1 expression within a ceRNA network.	0.3213
30153287	PloS one	2018	"Circular RNAs hsa_circ_0032462, hsa_circ_0028173, hsa_circ_0005909 are predicted to promote CADM1 expression by functioning as miRNAs sponge in human osteosarcoma."	hsa_circ_0005909	circRNA_0005909			osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	hsa_circ_0005909 is up-regulated in osteosarcoma cell lines and is predicted to sponge has-miR-338-3p to increase CADM1 expression within a ceRNA network.	0.3213
30161026	Molecular therapy. Nucleic acids	2018	A Transcriptome-Level Study Identifies Changing Expression Profiles for Ossification of the Ligamentum Flavum of the Spine.	hsa_circ_0050139				ossification of the ligamentum flavum 	MONDO:0045044	ligament disorder	up-regulated	RT-qPCR; Microarray	"circ_0050139 is up-regulated in OLF tissues and in osteogenic-induced hMSCs. Functionally, its knockdown suppresses osteogenic markers (ALP, COL1alpha1, BGLAP, RUNX2) and ALP staining, supporting a pro-ossification role. Mechanistically, it is described as a miR-19b-3p-associated circRNA in a ceRNA network affecting ossification-associated genes."	0.4474
30187887	Aging	2018	Comprehensive analysis of circRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of atherosclerosis in rabbits.		ocu-cirR-novel-18038	ocu_circ_FN1	FN1	atherosclerosis 	MONDO:0005311	atherosclerosis	down-regulated	RNA-seq	"ocu-cirR-novel-18038 is a down-regulated hub circRNA in a rabbit atherosclerosis ceRNA network, derived from the FN1 gene and predicted to compete with many mRNAs via shared miRNAs. It is implicated in processes such as cell adhesion/activation and immune response in the network context."	0.3963
30187887	Aging	2018	Comprehensive analysis of circRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of atherosclerosis in rabbits.		ocu-cirR-novel-18298			atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RNA-seq	"ocu-cirR-novel-18298 is up-regulated in rabbit atherosclerosis and is one of seven topological hub circRNAs in the dysregulated ceRNA network module, suggesting a central ceRNA role linked to immune/cell-adhesion related functions."	0.3963
30187887	Aging	2018	Comprehensive analysis of circRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of atherosclerosis in rabbits.		ocu-cirR-novel-15993			atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RNA-seq	"ocu-cirR-novel-15993 is up-regulated in rabbit atherosclerosis and is a hub circRNA in the dysregulated ceRNA network module, implicating it in miRNA-mediated competition with mRNAs linked to immune/cell-adhesion related processes."	0.3963
30187887	Aging	2018	Comprehensive analysis of circRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of atherosclerosis in rabbits.		ocu-cirR-novel-17934			atherosclerosis 	MONDO:0005311	atherosclerosis	down-regulated	RNA-seq	"ocu-cirR-novel-17934 is down-regulated in rabbit atherosclerosis and is one of the seven hub circRNAs highlighted from the dysregulated ceRNA network, suggesting a central miRNA-mediated competing role linked to immune/cell-adhesion related processes."	0.3963
30187887	Aging	2018	Comprehensive analysis of circRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of atherosclerosis in rabbits.		ocu-cirR-novel-17879			atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RNA-seq	"ocu-cirR-novel-17879 is up-regulated in rabbit atherosclerosis and identified as a hub circRNA in the dysregulated ceRNA network module, suggesting involvement in miRNA-mediated regulation of atherosclerosis-related gene programs."	0.3963
30187887	Aging	2018	Comprehensive analysis of circRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of atherosclerosis in rabbits.		ocu-cirR-novel-18036			atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RNA-seq	"ocu-cirR-novel-18036 is up-regulated in rabbit atherosclerosis and highlighted as a hub circRNA in the dysregulated ceRNA network module, suggesting involvement in miRNA-mediated competing regulation of atherosclerosis-related genes."	0.3963
30187887	Aging	2018	Comprehensive analysis of circRNA expression pattern and circRNA-miRNA-mRNA network in the pathogenesis of atherosclerosis in rabbits.		ocu-cirR-novel-14389			atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RNA-seq	"ocu-cirR-novel-14389 is up-regulated in rabbit atherosclerosis and highlighted as a hub circRNA in the dysregulated ceRNA network module, with potential diagnostic/therapeutic relevance proposed by the authors."	0.3963
30195762	Molecular therapy. Nucleic acids	2018	"LncRNA UCA1, Upregulated in CRC Biopsies and Downregulated in Serum Exosomes, Controls mRNA Expression by RNA-RNA Interactions."		CDR1AS	hsa_circ_CDR1		colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"CDR1AS was identified as significantly down-regulated in CRC tumor tissues compared with matched normal adjacent tissues in this cohort, but no functional mechanism for CDR1AS was investigated in this study."	0.2995
30195762	Molecular therapy. Nucleic acids	2018	"LncRNA UCA1, Upregulated in CRC Biopsies and Downregulated in Serum Exosomes, Controls mRNA Expression by RNA-RNA Interactions."		circHIPK3	hsa_circ_HIPK3	HIPK3	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circHIPK3 was up-regulated in serum exosomes from CRC patients versus healthy individuals and showed diagnostic potential (ROC AUC 0.771), with improved performance when combined with UCA1 (circHIPK3:UCA1 AUC 0.9). No downstream mechanism was investigated for circHIPK3 in this study."	0.4187
30197981	Kidney international reports	2018	The Circular RNA ciRs-126 Predicts Survival in Critically Ill Patients With Acute Kidney Injury.	hsa_circ_0003266		hsa_circ_LRIG1	LRIG1	acute kidney injury 	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR; Microarray	"In critically ill AKI patients at initiation of RRT, circulating ciRs-126 (hsa_circ_0003266) is significantly increased and is an independent predictor of 28-day mortality. It is predicted to sponge miR-126-5p based on bioinformatic target prediction, but direct binding was not definitively proven."	0.7278
30197981	Kidney international reports	2018	The Circular RNA ciRs-126 Predicts Survival in Critically Ill Patients With Acute Kidney Injury.	hsa_circ_0045881				acute kidney injury 	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR; Microarray	"hsa_circ_0045881 is a circulating circRNA detectable in whole blood and is elevated in AKI patients versus healthy controls, but it does not differentiate AKI from other critically ill/hemodialysis disease controls in this cohort."	0.5541
30197981	Kidney international reports	2018	The Circular RNA ciRs-126 Predicts Survival in Critically Ill Patients With Acute Kidney Injury.	hsa_circ_0001177				acute kidney injury 	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001177 is a circulating circRNA detectable in whole blood and is elevated in AKI patients versus healthy controls, but it does not distinguish AKI from other critically ill/hemodialysis disease controls in this cohort."	0.5541
30214434	Frontiers in microbiology	2018	Plasma Circular RNAs hsa_circ_0001953 and hsa_circ_0009024 as Diagnostic Biomarkers for Active Tuberculosis.	hsa_circ_0001953		hsa_circ_ZFY	ZFY	active tuberculosis 	MONDO:0100481	active tuberculosis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001953 is up-regulated in plasma from active TB patients and has diagnostic potential, especially when combined with hsa_circ_0009024. Its plasma level correlates with TB severity and decreases after successful anti-TB therapy. miRNA-binding partners were predicted bioinformatically, suggesting a possible miRNA-sponge role that was not experimentally validated."	0.5534
30214434	Frontiers in microbiology	2018	Plasma Circular RNAs hsa_circ_0001953 and hsa_circ_0009024 as Diagnostic Biomarkers for Active Tuberculosis.	hsa_circ_0009024		hsa_circ_TXLNGY	TXLNGY	active tuberculosis 	MONDO:0100481	active tuberculosis	up-regulated	RT-qPCR; Microarray	hsa_circ_0009024 is up-regulated in plasma from active TB patients and provides diagnostic utility alone and in combination with hsa_circ_0001953. Its level correlates with disease severity and decreases after treatment; plasma levels also moderately correlate with PBMC levels. Predicted miRNA-binding suggests a possible miRNA-sponge role without experimental validation.	0.5534
30214434	Frontiers in microbiology	2018	Plasma Circular RNAs hsa_circ_0001953 and hsa_circ_0009024 as Diagnostic Biomarkers for Active Tuberculosis.	hsa_circ_0008297		hsa_circ_DDX3Y	DDX3Y	active tuberculosis 	MONDO:0100481	active tuberculosis	up-regulated	RT-qPCR; Microarray	hsa_circ_0008297 is up-regulated in plasma of active TB patients based on microarray and RT-qPCR validation. It has modest diagnostic performance by ROC analysis and shows a weak correlation with TB radiological severity score.	0.5047
30214434	Frontiers in microbiology	2018	Plasma Circular RNAs hsa_circ_0001953 and hsa_circ_0009024 as Diagnostic Biomarkers for Active Tuberculosis.	hsa_circ_0003528		hsa_circ_SEC24A	SEC24A	active tuberculosis 	MONDO:0100481	active tuberculosis	up-regulated	RT-qPCR; Microarray	hsa_circ_0003528 is up-regulated in plasma of active TB patients based on microarray and RT-qPCR validation. It has moderate diagnostic performance in ROC analysis but does not correlate with radiological severity score in this study.	0.5047
30214434	Frontiers in microbiology	2018	Plasma Circular RNAs hsa_circ_0001953 and hsa_circ_0009024 as Diagnostic Biomarkers for Active Tuberculosis.	hsa_circ_0003524		hsa_circ_FAM168B	FAM168B	active tuberculosis 	MONDO:0100481	active tuberculosis	up-regulated	RT-qPCR; Microarray	hsa_circ_0003524 is up-regulated in plasma of active TB patients based on microarray and RT-qPCR validation. It provides diagnostic value by ROC analysis but does not correlate with radiological severity score in this study.	0.5047
30214434	Frontiers in microbiology	2018	Plasma Circular RNAs hsa_circ_0001953 and hsa_circ_0009024 as Diagnostic Biomarkers for Active Tuberculosis.	hsa_circ_0015879		hsa_circ_PKP1	PKP1	active tuberculosis 	MONDO:0100481	active tuberculosis	up-regulated	RT-qPCR; Microarray	hsa_circ_0015879 is up-regulated in plasma of active TB patients based on microarray and RT-qPCR validation. It has modest diagnostic value in ROC analysis but shows no association with radiological severity score in this study.	0.5047
30216431	Clinical and experimental immunology	2018	Identification of circular RNAs hsa_circ_0044235 in peripheral blood as novel biomarkers for rheumatoid arthritis.	hsa_circ_0044235		hsa_circ_CDC27	cdc27	rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	down-regulated	RT-qPCR	"hsa_circ_0044235 is significantly down-regulated in peripheral blood of RA patients and shows diagnostic value (AUC 0.779). The study predicts miRNA targets (including hsa-miR-892a) suggesting a possible circRNA/miRNA interaction, but the mechanism is not experimentally confirmed."	0.459
30236115	Molecular cancer	2018	CircRNA microarray profiling identifies a novel circulating biomarker for detection of gastric cancer.	hsa_circ_0130810		hsa_circ_KIAA1244	KIAA1244	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"circ-KIAA1244 (hsa_circ_0130810) is down-regulated in gastric cancer tissues, plasma, and GC cells. Its decreased plasma level correlates with advanced TNM stage/lymphatic metastasis, shows diagnostic value (ROC AUC ~0.75), and lower expression is associated with shorter overall survival; it is detectable in plasma exosomes and mainly localizes to the cytoplasm."	0.7781
30236141	Molecular cancer	2018	Circular RNA F-circEA-2a derived from EML4-ALK fusion gene promotes cell migration and invasion in non-small cell lung cancer.		F-circEA-2a	hsa_circ_EML4-ALK	EML4-ALK	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	dysregulated	RT-qPCR; Northern Blot	"F-circEA-2a is an EML4-ALK-v3b-derived fusion circRNA detected in EML4-ALK-positive NSCLC tumors. It is mainly cytoplasmic and promotes migration and invasion with minimal effect on proliferation, and it was not detectable in patient plasma in this study."	0.7441
30236833	Molecular therapy. Nucleic acids	2018	hsa_circ_0061140 Knockdown Reverses FOXM1-Mediated Cell Growth and Metastasis in Ovarian Cancer through miR-370 Sponge Activity.	hsa_circ_0061140				ovarian cancer	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"hsa_circ_0061140 is up-regulated in ovarian cancer cell lines and mainly localized in the cytoplasm. It promotes proliferation, migration, EMT and in vivo tumor growth by sponging miR-370 to upregulate FOXM1 (miR-370/FOXM1 axis)."	0.5997
30237723	OncoTargets and therapy	2018	Hsa_circ_0003998 promotes cell proliferation and invasion by targeting miR-326 in non-small cell lung cancer.	hsa_circ_0003998	circ_0003998			non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0003998 is upregulated in NSCLC tissues/cell lines and promotes proliferation and invasion. Mechanistically, it sponges miR-326 to relieve repression of Notch1, forming a hsa_circ_0003998/miR-326/Notch1 axis associated with poor prognosis."	0.7113
30245844	Cell discovery	2018	Annotation and functional clustering of circRNA expression in rhesus macaque brain during aging.		circCACNA2D1		CACNA2D1	brain aging 			up-regulated	RT-qPCR; Northern Blot; ISH; RNA-seq	circCACNA2D1 is up-regulated in aged (20-year) rhesus macaque brain and shows a negative correlation with (and likely suppresses) its host gene CACNA2D1 mRNA expression during brain aging.	0.7177
30245844	Cell discovery	2018	Annotation and functional clustering of circRNA expression in rhesus macaque brain during aging.		circCACNA1E		CACNA1E	brain aging 			up-regulated	RT-qPCR; Northern Blot; ISH; RNA-seq	circCACNA1E is up-regulated in aged (20-year) rhesus macaque brain and negatively correlates with (and likely suppresses) its host gene CACNA1E mRNA expression during brain aging.	0.7177
30261900	Molecular cancer	2018	Circular RNA hsa_circ_0008305 (circPTK2) inhibits TGF-beta-induced epithelial-mesenchymal transition and metastasis by controlling TIF1gamma in non-small cell lung cancer.	hsa_circ_0008305	hsa_circRNA_104703	hsa_circ_PTK2	PTK2	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Northern Blot; Microarray	"In NSCLC, circPTK2 (hsa_circ_0008305) is down-regulated during TGF-beta-induced EMT and in patient tumors, especially metastatic tissues. It suppresses EMT, invasion, and metastasis by sponging miR-429/miR-200b-3p to relieve repression of TIF1gamma, thereby dampening TGF-beta/Smad signaling output such as Snail."	0.8491
30263004	International journal of biological sciences	2018	A novel circulating hsa_circ_0081001 act as a potential biomarker for diagnosis and prognosis of osteosarcoma.	hsa_circ_0081001				osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0081001 is up-regulated in osteosarcoma cell lines, tumor tissues and patient serum, with higher levels in chemoresistant and lung-metastatic cases. High expression is associated with shorter overall survival and is an independent prognostic factor; serum levels show diagnostic value (AUC 0.898) and may dynamically reflect treatment response and disease progression."	0.7034
30271486	Journal of Cancer	2018	The effect of Hsa_circ_0001451 in clear cell renal cell carcinoma cells and its relationship with clinicopathological features.	hsa_circ_0001451				clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	down-regulated	RT-qPCR	"Hsa_circ_0001451 is down-regulated in ccRCC tissues and RCC cell lines and functions as a tumor-suppressive circRNA. Its knockdown increases ccRCC cell proliferation and reduces apoptosis. The study also predicts a ceRNA network involving Hsa-miR-140-5p, Hsa-miR-197-3p, and Hsa-miR-338-3p, and suggests potential diagnostic/prognostic value."	0.6806
30272257	International journal of molecular medicine	2018	Potential regulatory role of circular RNA in idiopathic pulmonary fibrosis.	hsa_circ_0023858	hsa_circRNA_100906	hsa_circ_ANKRD42	ANKRD42	idiopathic pulmonary fibrosis 	MONDO:0800504	idiopathic pulmonary fibrosis	up-regulated	RT-qPCR; Microarray	hsa_circRNA_100906 is up-regulated in IPF patient plasma and participates in a predicted ceRNA network. It directly binds miR-324-5p and is predicted to sequester miR-324-5p/miR-330-5p to modulate fibrosis-related target genes and pathways.	0.7164
30272257	International journal of molecular medicine	2018	Potential regulatory role of circular RNA in idiopathic pulmonary fibrosis.	hsa_circ_0044226	hsa_circRNA_102100	hsa_circ_CDC27	CDC27	idiopathic pulmonary fibrosis 	MONDO:0800504	idiopathic pulmonary fibrosis	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_102100 is up-regulated in IPF patient plasma and is included in the predicted circRNA_miRNA network, with miR-532-5p as its proposed interacting miRNA."	0.585
30272257	International journal of molecular medicine	2018	Potential regulatory role of circular RNA in idiopathic pulmonary fibrosis.	hsa_circ_0007535	hsa_circRNA_102348	hsa_circ_ELP2	ELP2	idiopathic pulmonary fibrosis 	MONDO:0800504	idiopathic pulmonary fibrosis	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_102348 is up-regulated in IPF plasma and directly binds miR-630 (luciferase-confirmed), supporting a ceRNA-type mechanism potentially affecting fibrosis-related targets and pathways."	0.7164
30272257	International journal of molecular medicine	2018	Potential regulatory role of circular RNA in idiopathic pulmonary fibrosis.	hsa_circ_0029633	hsa_circRNA_101225	hsa_circ_ZMYM2	ZMYM2	idiopathic pulmonary fibrosis 	MONDO:0800504	idiopathic pulmonary fibrosis	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_101225 is down-regulated in IPF plasma and was included in the predicted circRNA_miRNA network, with miR-326 as its proposed interacting miRNA."	0.585
30272257	International journal of molecular medicine	2018	Potential regulatory role of circular RNA in idiopathic pulmonary fibrosis.	hsa_circ_0001861	hsa_circRNA_104780 	hsa_circ_GRHPR	GRHPR	idiopathic pulmonary fibrosis 	MONDO:0800504	idiopathic pulmonary fibrosis	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_104780 is down-regulated in IPF plasma and was included in the predicted circRNA_miRNA network, with miR-650 as its proposed interacting miRNA."	0.585
30272257	International journal of molecular medicine	2018	Potential regulatory role of circular RNA in idiopathic pulmonary fibrosis.	hsa_circ_0029853	hsa_circRNA_101242	hsa_circ_PAN3	PAN3	idiopathic pulmonary fibrosis 	MONDO:0800504	idiopathic pulmonary fibrosis	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_101242 is down-regulated in IPF plasma and is predicted to bind miR-21-3p and miR-338-3p, but the direct interaction and downstream targets in IPF were not confirmed in this study."	0.585
30285878	Molecular cancer	2018	Circular RNA BCRC-3 suppresses bladder cancer proliferation through miR-182-5p/p27 axis.			hsa_circ_PSMD1	PSMD1	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"BCRC-3 (from PSMD1) is down-regulated in bladder cancer tissues and cell lines and predominantly localizes in the cytoplasm. It suppresses bladder cancer proliferation and tumor growth by sponging miR-182-5p, thereby enhancing p27 (CDKN1B) expression via p27 3'UTR regulation."	0.853
30286182	PloS one	2018	"Circular RNA and mRNA profiling reveal competing endogenous RNA networks during avian leukosis virus, subgroup J-induced tumorigenesis in chickens."		circRNA_1193	gga_circ_HRH4	HRH4 / Hrh4	"avian leukosis virus, subgroup J-induced tumorigenesis "	MONDO:0025381	avian leukosis	dysregulated	RT-qPCR; RNA-seq	"circHRH4 (circRNA_1193) is a chicken HRH4-derived exon-intron circRNA that is differentially expressed in ALV-J-infected spleen and included in the constructed ceRNA network. It localizes to the cytoplasm and is proposed to act in circRNA_miRNA_mRNA regulation, potentially affecting tumor/immune-related targets such as Mll and Aoc3 during ALV-J-induced tumorigenesis."	0.7063
30286182	PloS one	2018	"Circular RNA and mRNA profiling reveal competing endogenous RNA networks during avian leukosis virus, subgroup J-induced tumorigenesis in chickens."		circRNA_2573			"avian leukosis virus, subgroup J-induced tumorigenesis "	MONDO:0025381	avian leukosis	dysregulated	RT-qPCR; RNA-seq	circRNA_2573 was identified as a differentially expressed circRNA in ALV-J-infected versus uninfected chicken spleen and its dysregulation was validated by RT-qPCR consistent with RNA-seq.	0.4625
30286182	PloS one	2018	"Circular RNA and mRNA profiling reveal competing endogenous RNA networks during avian leukosis virus, subgroup J-induced tumorigenesis in chickens."		circRNA_0491			"avian leukosis virus, subgroup J-induced tumorigenesis "	MONDO:0025381	avian leukosis	dysregulated	RT-qPCR; RNA-seq	circRNA_0491 was identified as a differentially expressed circRNA in ALV-J-infected versus uninfected chicken spleen and its dysregulation was validated by RT-qPCR consistent with RNA-seq.	0.4625
30288120	Cancer management and research	2018	"CircZNF609 promotes breast cancer cell growth, migration, and invasion by elevating p70S6K1 via sponging miR-145-5p."			hsa_circ_ZNF609	ZNF609	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circZNF609 is up-regulated in breast cancer and promotes proliferation, migration, invasion, and xenograft tumor growth. It functions as a ceRNA by sponging miR-145-5p, which increases p70S6K1 expression; high circZNF609 is associated with poor overall survival."	0.8202
30298999	Brain and behavior	2018	Total saponins from the leaves of Panax notoginseng inhibit depression on mouse chronic unpredictable mild stress model by regulating circRNA expression.	mmu_circ_0001223				depression 	MONDO:0002050	depressive disorder	down-regulated	RT-qPCR; RNA-seq	"mmu_circ_0001223 is down-regulated in CUMS depression-like mice and is restored by SLPN treatment in VMPC and hippocampus. Its overexpression in PC12 cells increases CREB1 and BDNF mRNA/protein levels, suggesting it may contribute to SLPN¡¯s antidepressant effects via CREB1/BDNF-related signaling."	0.5491
30312173	Aging	2018	Circular RNA circUBXN7 represses cell growth and invasion by sponging miR-1247-3p to enhance B4GALT3 expression in bladder cancer.	hsa_circ_0001380	circUBXN7	hsa_circ_UBXN7	UBXN7	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"In bladder cancer, circUBXN7 is down-regulated and acts as a tumor suppressor. It sponges miR-1247-3p to increase B4GALT3 expression, thereby inhibiting proliferation, migration/invasion, and tumor growth; low circUBXN7 correlates with worse overall survival."	0.8836
30314467	BMC genomics	2018	Differentially expressed non-coding RNAs induced by transmissible gastroenteritis virus potentially regulate inflammation and NF-kappaB pathway in porcine intestinal epithelial cell line.		ssc_circ_001964			transmissible gastroenteritis 	MONDO:0002269	gastroenteritis	dysregulated	RT-qPCR; RNA-seq	ssc_circ_001964 was identified as a circular RNA and its differential expression in TGEV-infected IPEC-J2 cells was confirmed by qRT-PCR consistent with RNA-seq results; no specific mechanism or function was further characterized.	0.4835
30314467	BMC genomics	2018	Differentially expressed non-coding RNAs induced by transmissible gastroenteritis virus potentially regulate inflammation and NF-kappaB pathway in porcine intestinal epithelial cell line.		ssc_circ_000470			transmissible gastroenteritis 	MONDO:0002269	gastroenteritis	dysregulated	RT-qPCR; RNA-seq	"ssc_circ_000470 was confirmed to be circular and differentially expressed upon TGEV infection in IPEC-J2 cells, with qRT-PCR results consistent with RNA-seq; no downstream function/mechanism was characterized."	0.4835
30314467	BMC genomics	2018	Differentially expressed non-coding RNAs induced by transmissible gastroenteritis virus potentially regulate inflammation and NF-kappaB pathway in porcine intestinal epithelial cell line.		ssc_circ_005884			transmissible gastroenteritis 	MONDO:0002269	gastroenteritis	dysregulated	RT-qPCR; RNA-seq	ssc_circ_005884 was verified as a circRNA and its differential expression in TGEV-infected IPEC-J2 cells was confirmed by qRT-PCR consistent with RNA-seq; no functional mechanism was reported.	0.4835
30314467	BMC genomics	2018	Differentially expressed non-coding RNAs induced by transmissible gastroenteritis virus potentially regulate inflammation and NF-kappaB pathway in porcine intestinal epithelial cell line.		ssc_circ_009380			transmissible gastroenteritis 	MONDO:0002269	gastroenteritis	dysregulated	RT-qPCR; RNA-seq	"ssc_circ_009380 is differentially expressed in TGEV-infected IPEC-J2 cells and was validated as circular and by qRT-PCR. It binds miR-22 (dual-luciferase), and knockdown of ssc_circ_009380 reduces nuclear p65 accumulation and IkappaB-alpha phosphorylation, indicating it promotes NF-kappaB pathway activation during TGEV-induced inflammation."	0.7126
30320389	Molecular medicine reports	2018	"High_throughput sequencing reveals differentially expressed lncRNAs and circRNAs, and their associated functional network, in human hypertrophic scars."		circ-Chr17:50189167_ 50198002_- / 17_50189167_50198002_-			human hypertrophic scars 	MONDO:0005093	skin disorder	up-regulated	RT-qPCR; RNA-seq	This circRNA is up-regulated in hypertrophic scar tissues and was included in a predicted ceRNA network. It may act as a miR-338-3p sponge to affect THBS1/COL1A1-related fibrosis processes.	0.4032
30320389	Molecular medicine reports	2018	"High_throughput sequencing reveals differentially expressed lncRNAs and circRNAs, and their associated functional network, in human hypertrophic scars."		circ-Chr17:50189167_50194626_- / 17_50189167_50194626_-			human hypertrophic scars 	MONDO:0005093	skin disorder	up-regulated	RT-qPCR; RNA-seq	This circRNA is up-regulated in hypertrophic scar tissues and was included in a predicted ceRNA network. It may sponge miR-338-3p to modulate THBS1 and COL1A1.	0.4032
30320389	Molecular medicine reports	2018	"High_throughput sequencing reveals differentially expressed lncRNAs and circRNAs, and their associated functional network, in human hypertrophic scars."		circ-Chr17:50189858_50195330_- / 17_50189858_50195330_-			human hypertrophic scars 	MONDO:0005093	skin disorder	up-regulated	RT-qPCR; RNA-seq	This circRNA is up-regulated in hypertrophic scar tissues and was placed in a predicted ceRNA network. It may sponge miR-338-3p to influence THBS1/COL1A1.	0.4032
30320389	Molecular medicine reports	2018	"High_throughput sequencing reveals differentially expressed lncRNAs and circRNAs, and their associated functional network, in human hypertrophic scars."		circ-Chr17:50187014_50195976_-			human hypertrophic scars 	MONDO:0005093	skin disorder	unknown	RNA-seq	"This circRNA was included in a predicted ceRNA network in hypertrophic scar, potentially interacting with miR-338-3p and linked to THBS1/COL1A1. Its differential expression direction was not individually reported in the provided text."	0.348
30320389	Molecular medicine reports	2018	"High_throughput sequencing reveals differentially expressed lncRNAs and circRNAs, and their associated functional network, in human hypertrophic scars."		circ-Chr9:125337017_125337591_+			human hypertrophic scars 	MONDO:0005093	skin disorder	unknown	RNA-seq	"circ-Chr9:125337017_125337591_+ was incorporated into a predicted ceRNA network for hypertrophic scar, acting as a putative miR-182-5p sponge to influence multiple target mRNAs. It was also linked by co-expression to COL1A1 and TGFbeta3."	0.348
30320389	Molecular medicine reports	2018	"High_throughput sequencing reveals differentially expressed lncRNAs and circRNAs, and their associated functional network, in human hypertrophic scars."		circ-Chr12:120782654_120784593_-			human hypertrophic scars 	MONDO:0005093	skin disorder	unknown	RNA-seq	circ-Chr12:120782654_120784593_- was identified by RNA-seq as a hypertrophic-scar-associated circRNA and linked by co-expression analysis to COL1A1 and TGFbeta3. No specific miRNA axis or pathway mechanism was reported for this circRNA in the provided text.	0.348
30320389	Molecular medicine reports	2018	"High_throughput sequencing reveals differentially expressed lncRNAs and circRNAs, and their associated functional network, in human hypertrophic scars."		17_50190326_50194041_-			human hypertrophic scars 	MONDO:0005093	skin disorder	up-regulated	RT-qPCR; RNA-seq	"This circRNA (17_50190326_50194041_-) was validated by RT-qPCR as up-regulated in hypertrophic scar tissues relative to normal skin, but no downstream miRNA/target mechanism was specified."	0.3588
30336780	Molecular cancer	2018	Circular RNA YAP1 inhibits the proliferation and invasion of gastric cancer cells by regulating the miR-367-5p/p27 Kip1 axis.	hsa_circ_0002320	circYAP1	hsa_circ_YAP1	YAP1	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; ISH	circYAP1 (derived from YAP1) is down-regulated in gastric cancer tissues and acts as a tumor suppressor. It inhibits GC cell proliferation/cell-cycle progression and invasion and suppresses xenograft tumor growth by sponging miR-367-5p and thereby upregulating p27 Kip1. High circYAP1 expression is associated with longer overall survival and better chemotherapy outcomes.	0.8106
30338222	FEBS open bio	2018	Circular RNA expression profile of spleen in a Clostridium perfringens type C-induced piglet model of necrotizing enteritis.	ssc_circ_0002220		ssc_circ_IKBKBI	IKBKBI	necrotizing enteritis 	MONDO:0043579	enteritis	unknown	RNA-seq	"circ_0002220 was highlighted as an NE-related circRNA in the spleen of C. perfringens type C-infected piglets and is predicted to act as a miRNA sponge targeting miR-15b/miR-16, potentially linking to infection/immune-response pathways through its host gene IKBKBI."	0.0693
30338222	FEBS open bio	2018	Circular RNA expression profile of spleen in a Clostridium perfringens type C-induced piglet model of necrotizing enteritis.	ssc_circ_0002287		ssc_circ_RBL1	RBL1	necrotizing enteritis 	MONDO:0043579	enteritis	unknown	RNA-seq	"circ_0002287 was proposed as an NE-related spleen circRNA that may act as a miR-378 sponge, with its host gene RBL1 linked by enrichment to TGF-beta-related signaling."	0.0693
30338222	FEBS open bio	2018	Circular RNA expression profile of spleen in a Clostridium perfringens type C-induced piglet model of necrotizing enteritis.	ssc_circ_0003020				necrotizing enteritis 	MONDO:0043579	enteritis	unknown	RNA-seq	"circ_0003020 was included in the NE-related circRNA_miRNA network and is predicted to target miR-378, suggesting a potential miRNA-sponge role in the spleen response to C. perfringens type C infection."	0.0693
30338222	FEBS open bio	2018	Circular RNA expression profile of spleen in a Clostridium perfringens type C-induced piglet model of necrotizing enteritis.		novel_circ_0002919			necrotizing enteritis	MONDO:0043579	enteritis	unknown	RT-qPCR; RNA-seq	"novel_circ_0002919 was noted for having many predicted miRNA-binding sites in the spleen circRNA dataset, but the paper did not link it specifically to NE or validate its expression/function."	0.1904
30344708	Oncology letters	2018	Overexpression of circ-0067934 is associated with increased cellular proliferation and the prognosis of non-small cell lung cancer.	hsa_circ_0067934	circ-0067934 / circ_0067934			non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ-0067934 is up-regulated in NSCLC tissues and cell lines. Its high expression correlates with lymph node metastasis, advanced TNM stage, and poor overall survival, and it acts as an independent risk factor for OS. Functionally, circ-0067934 promotes NSCLC cell proliferation since siRNA-mediated knockdown reduces proliferation and colony formation."	0.6028
30344736	Oncology letters	2018	Expression of circ_001569 is upregulated in osteosarcoma and promotes cell proliferation and cisplatin resistance by activating the Wnt/beta-catenin signaling pathway.		hsa_circ_001569			osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ_001569 is up-regulated in osteosarcoma tissues and cell lines and is associated with distant metastasis and advanced TNM stage. Functionally, circ_001569 promotes osteosarcoma cell proliferation/colony formation and increases cisplatin (and other chemotherapy) resistance by activating the Wnt/beta-catenin signaling pathway."	0.5358
30344795	Disease markers	2018	Hsa_circ_0008309 May Be a Potential Biomarker for Oral Squamous Cell Carcinoma.	hsa_circ_0008309		hsa_circ_CUL3	CUL3	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0008309 is down-regulated in OSCC tissues and is associated with pathological differentiation, showing potential diagnostic value. Mechanistically, it is predicted and functionally supported to repress miR-136-5P/miR-382-5P and increase ATXN1 expression, consistent with a ceRNA-like role in OSCC cell lines."	0.7039
30349305	OncoTargets and therapy	2018	Circ-DLG1 promotes the proliferation of esophageal squamous cell carcinoma.	hsa_circ_0007203	circ-DLG1	hsa_circ_DLG1	DLG1	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"circ-DLG1 (hsa_circ_0007203), derived from DLG1 exons 13_18, is up-regulated in ESCC tissues, plasma, and ESCC cell lines. circ-DLG1 knockdown suppresses ESCC cell proliferation in vitro, and bioinformatics predicts it may sponge multiple miRNAs and relate to a circRNA_miRNA_mRNA network, suggesting biomarker potential in plasma."	0.743
30349810	Frontiers in oncology	2018	Circular RNA Expression in Oral Squamous Cell Carcinoma.	hsa_circ_0008202	circ_000334	hsa_circ_SPATA6	SPATA6	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR; RNA-seq	"circ_000334 (hsa_circ_0008202, from SPATA6) is significantly down-regulated in OSCC tissues and OSCC cell lines. Its downregulation is associated with pathological differentiation, and it is predicted to interact with miRNAs (miRNA-sponge/ceRNA-related role)."	0.585
30349810	Frontiers in oncology	2018	Circular RNA Expression in Oral Squamous Cell Carcinoma.	hsa_circ_0008309	circ_006740	hsa_circ_CUL3	CUL3	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR; RNA-seq	"circ_006740 (hsa_circ_0008309, from CUL3) is significantly down-regulated in OSCC tissues and OSCC cell lines. Its downregulation is associated with pathological differentiation, and it is bioinformatically predicted to bind miRNAs consistent with a miRNA-sponge role."	0.585
30349810	Frontiers in oncology	2018	Circular RNA Expression in Oral Squamous Cell Carcinoma.	hsa_circ_0004491	circ_006371			oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR; RNA-seq	"circ_006371 (hsa_circ_0004491) is significantly down-regulated in OSCC tissues and OSCC cell lines. The study predicts that it may bind miRNAs, suggesting a potential miRNA-sponge/ceRNA-related role in OSCC, but specific miRNAs/targets are not provided in the text."	0.585
30361504	Cell death & disease	2018	circRNA_104075 stimulates YAP-dependent tumorigenesis through the regulation of HNF4a and may serve as a diagnostic marker in hepatocellular carcinoma.		circRNA_104075			hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circ_104075 is up-regulated in HCC tissues, cell lines, and patient serum. It is transcriptionally induced by HNF4a and promotes HCC tumorigenesis by acting as a ceRNA that sponges miR-582-3p to increase YAP expression, and it shows strong diagnostic value in serum for distinguishing HCC from controls."	0.8008
30365065	International journal of molecular medicine	2019	CircRNA-associated ceRNA network reveals ErbB and Hippo signaling pathways in hypopharyngeal cancer.	hsa_circ_0008287		hsa_circ_GPATCH1	GPATCH1	hypopharyngeal cancer 	MONDO:0005806	hypopharynx cancer	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0008287 is down-regulated in hypopharyngeal cancer tissues. The study proposes it functions in a ceRNA subnetwork by sponging hsa-miR-548c-3p, thereby influencing ErbB and Hippo pathway gene regulation in HCa."	0.5135
30365065	International journal of molecular medicine	2019	CircRNA-associated ceRNA network reveals ErbB and Hippo signaling pathways in hypopharyngeal cancer.	hsa_circ_0005027		hsa_circ_ARHGAP32	ARHGAP32	hypopharyngeal cancer 	MONDO:0005806	hypopharynx cancer	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005027 is down-regulated in hypopharyngeal cancer tissues. The study proposes it participates in a ceRNA subnetwork by binding hsa-miR-548c-3p, influencing ErbB and Hippo pathway regulation in HCa."	0.5135
30367041	Nature communications	2018	A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma.	hsa_circ_0082389	circPINTexon2 / circ-0082389	hsa_circ_LINC-PINT	LINC-PINT	glioblastoma 	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR; RNA-seq	"circPINTexon2 (circular exon 2 of LINC-PINT) is down-regulated in glioblastoma. It functions mainly by encoding the peptide PINT87aa, which interacts with the PAF1 complex and suppresses transcriptional elongation of oncogenic programs, leading to G1 arrest and reduced proliferation/tumorigenesis in vitro and in vivo."	0.8386
30387298	Cancer science	2019	Silencing circular RNA UVRAG inhibits bladder cancer growth and metastasis by targeting the microRNA-223/fibroblast growth factor receptor 2 axis.	hsa_circ_0023642		hsa_circ_UVRAG	UVRAG	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circUVRAG is up-regulated in bladder cancer cell lines and mainly localized in the cytoplasm. circUVRAG promotes proliferation and migration/metastasis by sponging miR-223, thereby increasing FGFR2 expression; silencing circUVRAG suppresses tumor growth and metastasis in vitro and in a nude mouse xenograft model."	0.5997
30402980	Cancer medicine	2018	Dysregulated circular RNAs in medulloblastoma regulate proliferation and growth of tumor cells via host genes.	hsa_circ_0029696	circ_SKA3	hsa_circ_SKA3	SKA3	medulloblastoma 	MONDO:0007959	medulloblastoma	up-regulated	RT-qPCR; RNA-seq	"circ_SKA3 is upregulated in medulloblastoma tissues and functions as an oncogenic circRNA in DAOY cells. Its knockdown suppresses proliferation, migration and invasion, and these effects are rescued by SKA3 overexpression, supporting a host-gene_dependent mechanism."	0.6676
30402980	Cancer medicine	2018	Dysregulated circular RNAs in medulloblastoma regulate proliferation and growth of tumor cells via host genes.	hsa_circ_0000179	circ_DTL	hsa_circ_DTL	DTL	medulloblastoma 	MONDO:0007959	medulloblastoma	up-regulated	RT-qPCR; RNA-seq	"circ_DTL is upregulated in medulloblastoma tissues and promotes malignant phenotypes in DAOY cells. Silencing circ_DTL reduces proliferation, migration and invasion, and DTL overexpression rescues these effects, indicating a host-gene_dependent oncogenic mechanism."	0.6676
30402980	Cancer medicine	2018	Dysregulated circular RNAs in medulloblastoma regulate proliferation and growth of tumor cells via host genes.		circ_CRTAM	hsa_circ_CRTAM	CRTAM	medulloblastoma 	MONDO:0007959	medulloblastoma	down-regulated	RT-qPCR; RNA-seq	"circ_CRTAM is significantly downregulated in medulloblastoma tissues compared with normal cerebellum and was validated by RT-qPCR, but no functional or mechanistic experiments were reported for this circRNA."	0.3588
30402980	Cancer medicine	2018	Dysregulated circular RNAs in medulloblastoma regulate proliferation and growth of tumor cells via host genes.	hsa_circ_0006856	circ_MAP3K5	hsa_circ_MAP3K5	MAP3K5	medulloblastoma 	MONDO:0007959	medulloblastoma	down-regulated	RT-qPCR; RNA-seq	"circ_MAP3K5 is significantly downregulated in medulloblastoma tissues compared with normal cerebellum and was confirmed by RT-qPCR, but the paper does not report downstream functional assays or mechanisms for this circRNA."	0.3588
30402980	Cancer medicine	2018	Dysregulated circular RNAs in medulloblastoma regulate proliferation and growth of tumor cells via host genes.	hsa_circ_0132250		hsa_circ_RIMS1	RIMS1	medulloblastoma 	MONDO:0007959	medulloblastoma	down-regulated	RT-qPCR; RNA-seq	"circ_RIMS1_1 is downregulated in medulloblastoma tissues compared with normal cerebellum and was included among circRNAs validated by RT-qPCR, but no specific functional mechanism was experimentally investigated for it in this study."	0.3588
30402980	Cancer medicine	2018	Dysregulated circular RNAs in medulloblastoma regulate proliferation and growth of tumor cells via host genes.	hsa_circ_0100165		hsa_circ_FLT3	FLT3	medulloblastoma 	MONDO:0007959	medulloblastoma	down-regulated	RT-qPCR; RNA-seq	"circ_FLT3_1 is downregulated in medulloblastoma tissues compared with normal cerebellum and was among circRNAs validated by RT-qPCR, but the study reports no dedicated functional assays or mechanistic axis for this circRNA."	0.3588
30403259	Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas	2018	Circular RNA hsa_circ_0000523 regulates the proliferation and apoptosis of colorectal cancer cells as miRNA sponge.	hsa_circ_0000523	circ_006229			colorectal cancer	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"hsa_circ_0000523 is down-regulated in colorectal cancer cell lines and functions as a tumor-suppressive circRNA by inhibiting proliferation and promoting apoptosis. Mechanistically, it sponges miR-31 and thereby suppresses Wnt/beta-catenin signaling (with effects on Dkk1, nuclear beta-catenin and c-Myc)."	0.5223
30405788	Oncology letters	2018	Upregulation of circRNA_0000285 serves as a prognostic biomarker for nasopharyngeal carcinoma and is involved in radiosensitivity.	hsa_circ_0000285		hsa_circ_HIPK3	HIPK3	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"circRNA_0000285 (HIPK3-derived) is up-regulated in NPC tissues, NPC cell lines, and patient serum, and higher serum levels are linked to radioresistant NPC. High circRNA_0000285 expression is associated with adverse clinicopathological features and poorer overall survival, suggesting it is a prognostic biomarker and may predict radiotherapy response."	0.4758
30405847	Journal of Cancer	2018	Human papillomavirus 16 E7 oncoprotein alters the expression profiles of circular RNAs in Caski cells.	hsa_circ_0048867		hsa_circ_C3	C3	cervical cancer	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0048867 was up-regulated upon HPV16 E7 knockdown in HPV16-positive cervical cancer cell lines and is predicted to interact with hsa-miR-1180-3p, suggesting a potential miRNA-sponge/ceRNA-related role downstream of E7 regulation."	0.3684
30405847	Journal of Cancer	2018	Human papillomavirus 16 E7 oncoprotein alters the expression profiles of circular RNAs in Caski cells.	hsa_circ_0038475		hsa_circ_UQCRC2	UQCRC2	cervical cancer	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0038475 (UQCRC2-derived) was up-regulated after HPV16 E7 knockdown in HPV16-positive cervical cancer cells and is predicted to bind hsa-miR-181b-3p, implying a possible ceRNA/miRNA-sponge relationship influenced by E7 status."	0.3684
30405847	Journal of Cancer	2018	Human papillomavirus 16 E7 oncoprotein alters the expression profiles of circular RNAs in Caski cells.	hsa_circ_0035918		hsa_circ_PTPLAD1	PTPLAD1	cervical cancer	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0035918 (from PTPLAD1) increased after HPV16 E7 knockdown in HPV16-positive cervical cancer cell lines and was computationally linked to hsa-miR-181a-2-3p, supporting a predicted circRNA_miRNA interaction under E7 regulation."	0.3684
30405847	Journal of Cancer	2018	Human papillomavirus 16 E7 oncoprotein alters the expression profiles of circular RNAs in Caski cells.	hsa_circ_0056353		hsa_circ_WDR33	WDR33	cervical cancer	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0056353 (WDR33-derived) is up-regulated when HPV16 E7 is silenced in HPV16-positive cervical cancer cells and is predicted to bind hsa-miR-132-5p, consistent with a putative miRNA-sponge role associated with E7-dependent circRNA changes."	0.3684
30405847	Journal of Cancer	2018	Human papillomavirus 16 E7 oncoprotein alters the expression profiles of circular RNAs in Caski cells.	hsa_circ_0026527		hsa_circ_EIF4B	EIF4B	cervical cancer	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0026527 (EIF4B-derived) is up-regulated upon HPV16 E7 knockdown in HPV16-positive cervical cancer cell lines and is predicted to interact with hsa-miR-15b-3p, indicating a potential E7-linked circRNA_miRNA regulatory relationship."	0.3684
30405847	Journal of Cancer	2018	Human papillomavirus 16 E7 oncoprotein alters the expression profiles of circular RNAs in Caski cells.	hsa_circ_0037213		hsa_circ_FAM195A	FAM195A	cervical cancer	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0037213 (FAM195A-derived) is up-regulated after HPV16 E7 silencing in HPV16-positive cervical cancer cells and is predicted to bind hsa-miR-212-5p, consistent with a putative E7-associated circRNA_miRNA interaction network."	0.3684
30405847	Journal of Cancer	2018	Human papillomavirus 16 E7 oncoprotein alters the expression profiles of circular RNAs in Caski cells.	hsa_circ_0051620		hsa_circ_SLC1A5	SLC1A5	cervical cancer	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0051620 (SLC1A5-derived) is down-regulated after HPV16 E7 knockdown in HPV16-positive cervical cancer cell lines and is predicted to bind hsa-miR-3144-5p, suggesting a potential E7-linked circRNA_miRNA interaction."	0.3684
30405847	Journal of Cancer	2018	Human papillomavirus 16 E7 oncoprotein alters the expression profiles of circular RNAs in Caski cells.	hsa_circ_0052602		hsa_circ_ODC1	ODC1	cervical cancer	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0052602 (ODC1-derived) is down-regulated when HPV16 E7 is knocked down in HPV16-positive cervical cancer cells and is predicted to bind hsa-miR-497-5p, indicating a potential circRNA_miRNA interaction affected by E7 expression."	0.3684
30410722	Cell & bioscience	2018	Circ_0027599/PHDLA1 suppresses gastric cancer progression by sponging miR-101-3p.1.	hsa_circ_0027599	circ_0027599	hsa_circ_PHLDA1	PHLDA1	gastric cancer	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"In gastric cancer, circ_0027599 is down-regulated in tumors and blood and functions as a tumor suppressor by inhibiting proliferation and metastasis-related behaviors. Mechanistically, it sponges miR-101-3p.1 (miR-101) to relieve repression of PHLDA1, forming a circ_0027599/miR-101/PHLDA1 regulatory axis with potential diagnostic relevance."	0.6777
30413800	Molecular psychiatry	2020	CircDYM ameliorates depressive-like behavior by targeting miR-9 to regulate microglial activation via HSP90 ubiquitination.		circDYM / Circular RNA DYM	mmu_circ_DYM	DYM	major depressive disorder 	MONDO:0002009	major depressive disorder	down-regulated	RT-qPCR	"circDYM is down-regulated in MDD patient peripheral blood and in depressive-like mouse models. Restoring circDYM suppresses microglial activation and improves depressive-like behaviors by sponging miR-9, thereby upregulating HECTD1 and promoting HSP90 ubiquitination."	0.8569
30416748	Future science OA	2018	Profiling and bioinformatics analyses of differential circular RNA expression in prostate cancer cells.	hsa_circ_0039943	CircSLC7A6	hsa_circ_SLC7A6	SLC7A6	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; RNA-seq	"In prostate cancer cell line models, CircSLC7A6 (hsa_circ_0039943) is up-regulated in PC3 vs 22RV1 and is predicted (bioinformatically) to bind miR-143, suggesting a potential ceRNA role related to PCa progression/bone metastasis."	0.4276
30416748	Future science OA	2018	Profiling and bioinformatics analyses of differential circular RNA expression in prostate cancer cells.	hsa_circ_0008602	CircGUCY1A2	hsa_circ_GUCY1A2	GUCY1A2	prostate cancer 	MONDO:0008315	prostate cancer	dysregulated	RT-qPCR; RNA-seq	"CircGUCY1A2 (hsa_circ_0008602) shows differential expression across prostate cancer cell line comparisons and is predicted to bind miR200c/miR-200b, implying a potential ceRNA interaction related to PCa development."	0.4276
30416748	Future science OA	2018	Profiling and bioinformatics analyses of differential circular RNA expression in prostate cancer cells.		CircZFP57	hsa_circ_ZFP57	ZFP57	prostate cancer 	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; RNA-seq	"CircZFP57 is down-regulated in prostate cancer cell line comparisons and is predicted to bind miR-21, suggesting a potential ceRNA interaction relevant to PCa development."	0.4276
30416748	Future science OA	2018	Profiling and bioinformatics analyses of differential circular RNA expression in prostate cancer cells.	hsa_circ_0001946	CDR1as	hsa_circ_CDR1	CDR1	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; RNA-seq	"CDR1as (hsa_circ_0001946) is highly up-regulated in PC3 cells and is proposed to contribute to bone metastatic progression of prostate cancer, consistent with a miR-7 sponge mechanism."	0.4276
30416748	Future science OA	2018	Profiling and bioinformatics analyses of differential circular RNA expression in prostate cancer cells.	hsa_circ_0061259	CircBAGE2	hsa_circ_BAGE2	BAGE2	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; RNA-seq	"CircBAGE2 (hsa_circ_0061259) is up-regulated in 22RV1 vs RWPE-1 and is suggested to be relevant to PCa progression, potentially via interaction with miR-103a and downstream PDCD10."	0.4276
30417418	Journal of cellular biochemistry	2019	CircABCB10 promotes nonsmall cell lung cancer cell proliferation and migration by regulating the miR-1252/FOXR2 axis.	hsa_circ_0008717		hsa_circ_ABCB10	ABCB10	nonsmall cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circABCB10 (hsa_circ_0008717) is up-regulated in NSCLC cell lines and promotes proliferation, migration, and xenograft tumor growth. Mechanistically, it acts as a miR-1252 sponge to relieve repression of FOXR2, forming a circABCB10/miR-1252/FOXR2 ceRNA axis."	0.5607
30424816	Journal of experimental & clinical cancer research : CR	2018	CircRNA circRNA_102171 promotes papillary thyroid cancer progression through modulating CTNNBIP1-dependent activation of beta-catenin pathway.		circRNA_102171	hsa_circ_SMURF2	SMURF2	papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"circRNA_102171 is up-regulated in papillary thyroid cancer tissues/cell lines and functions as an oncogenic circRNA by promoting proliferation, migration, invasion and tumor growth while inhibiting apoptosis. Mechanistically, it binds CTNNBIP1 and disrupts CTNNBIP1_beta-catenin binding, enhancing beta-catenin association with TCF/LEF and activating Wnt/beta-catenin signaling."	0.7458
30425526	OncoTargets and therapy	2018	Contribution of dysregulated circRNA_100876 to proliferation and metastasis of esophageal squamous cell carcinoma.		circRNA_100876	hsa_circ_RNF121	RNF121	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"circRNA_100876 is up-regulated in ESCC tissues and ESCC cell lines and higher expression predicts worse RFS/OS. Functional assays show that circRNA_100876 promotes proliferation, migration, invasion and EMT, while its knockdown induces apoptosis and G2/M arrest and suppresses xenograft tumor growth. The paper suggests a ceRNA-like mechanism involving miR-136 and MMP13."	0.6221
30425578	Cancer management and research	2018	CircRNA CDR1as/miR-7 signals promote tumor growth of osteosarcoma with a potential therapeutic and diagnostic value.		CDR1as	hsa_circ_CDR1	CDR1	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"CDR1as is up-regulated in osteosarcoma and shows diagnostic potential. Functionally, it promotes OS cell proliferation/viability and migration and suppresses apoptosis and G1/S arrest by antagonizing miR-7 and de-repressing miR-7 targets (EGFR, CCNE1, PIK3CD, RAF1), also enhancing EMT marker changes."	0.7221
30442201	Stem cell research & therapy	2018	Circular RNAs are abundantly expressed and upregulated during repair of the damaged endometrium by Wharton's jelly-derived mesenchymal stem cells.		hsa-circRNA8881-21	hsa_circ_ASPM	ASPM	damaged endometrium 	MONDO:0000931	endometrial disorder	up-regulated	RT-qPCR; Microarray	hsa-circRNA8881-21 (host gene ASPM) is significantly up-regulated in damaged ESCs after coculture with WJ-MSCs during endometrial repair. The study reports its differential expression but does not experimentally define a specific miRNA/mRNA axis or mechanism for this circRNA.	0.3588
30442201	Stem cell research & therapy	2018	Circular RNAs are abundantly expressed and upregulated during repair of the damaged endometrium by Wharton's jelly-derived mesenchymal stem cells.	hsa_circ_0020492		hsa_circ_MKI67	MKI67	damaged endometrium 	MONDO:0000931	endometrial disorder	up-regulated	RT-qPCR; Microarray	hsa_circ_0020492 (host gene MKI67) is significantly up-regulated in damaged ESCs cocultured with WJ-MSCs during endometrial repair. No specific downstream miRNA/mRNA mechanism is experimentally validated for this circRNA in the paper.	0.3588
30442201	Stem cell research & therapy	2018	Circular RNAs are abundantly expressed and upregulated during repair of the damaged endometrium by Wharton's jelly-derived mesenchymal stem cells.	hsa_circ_0026141		hsa_circ_TROAP	TROAP	damaged endometrium 	MONDO:0000931	endometrial disorder	up-regulated	RT-qPCR; Microarray	hsa_circ_0026141 (host gene TROAP) is significantly up-regulated in damaged ESCs cocultured with WJ-MSCs during endometrial repair. The paper does not provide a validated interaction axis or mechanism for this circRNA.	0.3588
30442201	Stem cell research & therapy	2018	Circular RNAs are abundantly expressed and upregulated during repair of the damaged endometrium by Wharton's jelly-derived mesenchymal stem cells.		hsa-circRNA4049-38	hsa_circ_WDR62	WDR62	damaged endometrium 	MONDO:0000931	endometrial disorder	up-regulated	RT-qPCR; Microarray	"hsa-circRNA4049-38 (host gene WDR62) is significantly up-regulated in damaged ESCs after coculture with WJ-MSCs, suggesting association with the endometrial repair process. No specific regulatory axis is validated for this circRNA."	0.3588
30442201	Stem cell research & therapy	2018	Circular RNAs are abundantly expressed and upregulated during repair of the damaged endometrium by Wharton's jelly-derived mesenchymal stem cells.	hsa_circ_0015825		hsa_circ_KIF14	KIF14	damaged endometrium 	MONDO:0000931	endometrial disorder	up-regulated	RT-qPCR; Microarray	hsa_circ_0015825 (host gene KIF14) is significantly up-regulated in damaged ESCs in the WJ-MSC coculture repair condition. The study reports expression dynamics but does not validate a mechanistic axis for this circRNA.	0.3588
30442201	Stem cell research & therapy	2018	Circular RNAs are abundantly expressed and upregulated during repair of the damaged endometrium by Wharton's jelly-derived mesenchymal stem cells.		hsa-circRNA5028-15	hsa_circ_MYBL2	MYBL2	damaged endometrium 	MONDO:0000931	endometrial disorder	up-regulated	RT-qPCR; Microarray	hsa-circRNA5028-15 (host gene MYBL2) is significantly up-regulated in damaged ESCs under WJ-MSC-mediated repair conditions. The paper does not experimentally validate its miRNA targets or downstream effectors.	0.3588
30442201	Stem cell research & therapy	2018	Circular RNAs are abundantly expressed and upregulated during repair of the damaged endometrium by Wharton's jelly-derived mesenchymal stem cells.	hsa_circ_0111659		hsa_circ_KIF14	KIF14	damaged endometrium 	MONDO:0000931	endometrial disorder	up-regulated	RT-qPCR; Microarray	"hsa_circ_0111659 is up-regulated in damaged ESCs during WJ-MSC-mediated endometrial repair. The study predicts a ceRNA network in which hsa_circRNA_0111659 may sponge miR-17-5p/miR-20b-5p/miR-93-5p to relieve repression of VEGF, potentially promoting angiogenesis in repair; however, this axis is computationally predicted and not functionally validated."	0.4032
30446877	Functional & integrative genomics	2019	Comprehensive analysis of microarray expression profiles of circRNAs and lncRNAs with associated co-expression networks in human colorectal cancer.		hsa_circRNA_100085			colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circRNA_100085 is up-regulated in colorectal cancer tissues (and shows similar changes in serum) compared with controls, and its expression is significantly associated with tumor size and TNM stage. The study did not establish a specific downstream mechanism or interaction axis for this circRNA."	0.3588
30454010	Molecular cancer	2018	The pro-metastasis effect of circANKS1B in breast cancer.	hsa_circ_0007294	CircANKS1B	hsa_circ_ANKS1B	ANKS1B	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	"circANKS1B is up-regulated in TNBC and promotes invasion/metastasis by inducing EMT. It sponges miR-148a-3p and miR-152-3p to de-repress USF1, which up-regulates TGF-beta1 and activates TGF-beta/SMAD signaling; ESRP1 promotes circANKS1B biogenesis, forming a pro-metastatic feedback loop."	0.8945
30458784	Molecular cancer	2018	Invasion-related circular RNA circFNDC3B inhibits bladder cancer progression through the miR-1178-3p/G3BP2/SRC/FAK axis.	hsa_circ_0006156	circFNDC3B	hsa_circ_FNDC3B	FNDC3B	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"circFNDC3B (hsa_circ_0006156), derived from FNDC3B, is down-regulated in bladder cancer and acts as a tumor suppressor. It sponges miR-1178-3p to reduce G3BP2 and inactivate SRC/FAK signaling, thereby inhibiting proliferation, migration/invasion, tumor growth and lymphatic metastasis; low circFNDC3B is associated with poorer overall survival."	0.8837
30470261	Molecular cancer	2018	CircSLC3A2 functions as an oncogenic factor in hepatocellular carcinoma by sponging miR-490-3p and regulating PPM1F expression.	hsa_circ_0022587	circSLC3A2	hsa_circ_SLC3A2	SLC3A2	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH	"circSLC3A2 (hsa_circ_0022587), derived from SLC3A2, is up-regulated in HCC and mainly localized in the cytoplasm. It promotes HCC cell proliferation and invasion by acting as a sponge for miR-490-3p, thereby increasing PPM1F expression, and high circSLC3A2 correlates with poorer patient survival."	0.8416
30470262	Molecular cancer	2018	EIF4A3-induced circular RNA MMP9 (circMMP9) acts as a sponge of miR-124 and promotes glioblastoma multiforme cell tumorigenesis.	hsa_circ_0001162	circMMP9	hsa_circ_MMP9	MMP9	glioblastoma multiforme 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; ISH; Microarray	"circMMP9 (hsa_circ_0001162), derived from MMP9, is up-regulated in GBM tissues and acts as an oncogenic circRNA. It mainly localizes in the cytoplasm and promotes GBM proliferation, migration, invasion and xenograft growth by sponging miR-124, thereby increasing CDK4 and AURKA expression; its biogenesis is promoted by the splicing factor eIF4A3."	0.8745
30483394	Iranian journal of basic medical sciences	2018	CircRNA_0109291 regulates cell growth and migration in oral squamous cell carcinoma and its clinical significance.	hsa_circ_0109291	CircRNA_0109291	hsa_circ_ZNF714	ZNF714	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0109291 is up-regulated in OSCC tissues and cell lines. Its knockdown suppresses proliferation and migration and induces apoptosis in OSCC cells, and high tumor expression is associated with advanced TNM stage and poorer overall survival."	0.6516
30486834	Journal of translational medicine	2018	Crosstalk in competing endogenous RNA networks reveals new circular RNAs involved in the pathogenesis of early HIV infection.		chr16:68155890_68160513+			early HIV infection 	MONDO:0005109	HIV infectious disease	up-regulated	RT-qPCR	"This circRNA is up-regulated in HARRT-naive early HIV infection (EHI) PBMCs compared with healthy controls, but not up-regulated in chronic HIV infection (CHI), suggesting a potential EHI-stage-specific role."	0.2995
30486834	Journal of translational medicine	2018	Crosstalk in competing endogenous RNA networks reveals new circular RNAs involved in the pathogenesis of early HIV infection.		chr17:59853762_59857762_			early HIV infection 	MONDO:0005109	HIV infectious disease	up-regulated	RT-qPCR	"This circRNA is up-regulated in HARRT-naive early HIV infection (EHI) PBMCs compared with healthy controls, but not up-regulated in chronic HIV infection (CHI), suggesting a potential EHI-stage-specific role."	0.2995
30486834	Journal of translational medicine	2018	Crosstalk in competing endogenous RNA networks reveals new circular RNAs involved in the pathogenesis of early HIV infection.		chr15:55516087_55527154_			chronic HIV infection 	MONDO:0012268	AIDS	dysregulated	RT-qPCR	"This circRNA is implicated in an HIV-1 replication-associated ceRNA network, potentially acting as a ceRNA of miR-548ah-3p to regulate IL-15 and thereby influence viral set point. Its expression in CHI is higher than in EHI, suggesting association with infection status or progression."	0.348
30486834	Journal of translational medicine	2018	Crosstalk in competing endogenous RNA networks reveals new circular RNAs involved in the pathogenesis of early HIV infection.		chr19:8619361_8620680_			chronic HIV infection 	MONDO:0012268	AIDS	dysregulated	RT-qPCR	"This circRNA shows higher expression in chronic HIV infection (CHI) than in early HIV infection (EHI), suggesting association with HIV infection status or disease progression, but no specific molecular mechanism was established for this circRNA in the text provided."	0.2995
30486834	Journal of translational medicine	2018	Crosstalk in competing endogenous RNA networks reveals new circular RNAs involved in the pathogenesis of early HIV infection.		chr16:19656208_19663412+			early HIV infection 	MONDO:0005109	HIV infectious disease	unknown	RNA-seq	"This circRNA is part of an HIV-1 replication-associated ceRNA network and is predicted to act as a miR-548ah-3p sponge to regulate IL-15, potentially affecting viral set point in early HIV infection."	0.1768
30497053	Molecular therapy. Nucleic acids	2018	circGprc5a Promoted Bladder Oncogenesis and Metastasis through Gprc5a-Targeting Peptide.		hsa_circ_02838 / circGprc5a	hsa_circ_Gprc5a	Gprc5a	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; ISH	"circGprc5a is upregulated in bladder cancer and bladder CSCs and promotes CSC maintenance, self-renewal, invasion/metastasis and tumor propagation. Mechanistically, it encodes a peptide that binds Gprc5a and functions in a peptide- and Gprc5a-dependent manner, implicating GPCR signaling and providing a potential therapeutic targeting axis."	0.749
30497055	Molecular therapy. Nucleic acids	2018	Circular RNA Transcriptomic Analysis of Primary Human Brain Microvascular Endothelial Cells Infected with Meningitic Escherichia coli.	hsa_circ_0000395	hg38_circ_0000395		ENSG00000182022	E. coli-induced bacterial meningitis 	MONDO:0006753	Escherichia coli meningitis	down-regulated	RT-qPCR; RNA-seq	"hg38_circ_0000395 is significantly downregulated in primary hBMECs after meningitic E. coli infection, validated by RT-qPCR consistent with RNA-seq/circRNA-seq profiling. No specific miRNA/mRNA regulatory axis was experimentally established for this circRNA in the study."	0.585
30497055	Molecular therapy. Nucleic acids	2018	Circular RNA Transcriptomic Analysis of Primary Human Brain Microvascular Endothelial Cells Infected with Meningitic Escherichia coli.	hsa_circ_0008815	hg38_circ_0008815		ENSG00000140455	E. coli-induced bacterial meningitis 	MONDO:0006753	Escherichia coli meningitis	down-regulated	RT-qPCR; RNA-seq	hg38_circ_0008815 is significantly downregulated in primary hBMECs upon meningitic E. coli infection and this change was validated by RT-qPCR consistent with sequencing data. The study did not report a specific ceRNA axis for this circRNA.	0.585
30497055	Molecular therapy. Nucleic acids	2018	Circular RNA Transcriptomic Analysis of Primary Human Brain Microvascular Endothelial Cells Infected with Meningitic Escherichia coli.	hsa_circ_0033002	hg38_circ_0033002		ENSG00000112320	E. coli-induced bacterial meningitis 	MONDO:0006753	Escherichia coli meningitis	down-regulated	RT-qPCR; RNA-seq	"hg38_circ_0033002 is significantly downregulated in primary hBMECs following meningitic E. coli infection, confirmed by RT-qPCR. The paper did not experimentally define its downstream miRNA/mRNA targets."	0.585
30497055	Molecular therapy. Nucleic acids	2018	Circular RNA Transcriptomic Analysis of Primary Human Brain Microvascular Endothelial Cells Infected with Meningitic Escherichia coli.	hsa_circ_0014254	hg38_circ_0014254		ENSG00000150477	E. coli-induced bacterial meningitis 	MONDO:0006753	Escherichia coli meningitis	up-regulated	RT-qPCR; RNA-seq	hg38_circ_0014254 is significantly upregulated in primary hBMECs upon meningitic E. coli infection and was validated by RT-qPCR in agreement with sequencing results. No specific miRNA/mRNA interactions were experimentally validated for this circRNA in the paper.	0.585
30497055	Molecular therapy. Nucleic acids	2018	Circular RNA Transcriptomic Analysis of Primary Human Brain Microvascular Endothelial Cells Infected with Meningitic Escherichia coli.	hsa_circ_0019064	hg38_circ_0019064		ENSG00000135749	E. coli-induced bacterial meningitis 	MONDO:0006753	Escherichia coli meningitis	up-regulated	RT-qPCR; RNA-seq	"hg38_circ_0019064 is significantly upregulated in primary hBMECs in response to meningitic E. coli infection, with RT-qPCR validation consistent with sequencing. No direct functional/mechanistic validation for this circRNA was reported."	0.585
30497055	Molecular therapy. Nucleic acids	2018	Circular RNA Transcriptomic Analysis of Primary Human Brain Microvascular Endothelial Cells Infected with Meningitic Escherichia coli.	hsa_circ_0035876	hg38_circ_0035876		ENSG00000055609	E. coli-induced bacterial meningitis 	MONDO:0006753	Escherichia coli meningitis	up-regulated	RT-qPCR; RNA-seq	"hg38_circ_0035876 is significantly upregulated in primary hBMECs after meningitic E. coli infection, and RT-qPCR verified the sequencing trend. The study did not provide a validated downstream miRNA/mRNA mechanism for this circRNA."	0.585
30497055	Molecular therapy. Nucleic acids	2018	Circular RNA Transcriptomic Analysis of Primary Human Brain Microvascular Endothelial Cells Infected with Meningitic Escherichia coli.	hsa_circ_0008980	hg38_circ_0008980			E. coli-induced bacterial meningitis 	MONDO:0006753	Escherichia coli meningitis	up-regulated	RT-qPCR; RNA-seq	"hg38_circ_0008980 is upregulated upon meningitic E. coli infection and functions as a ceRNA by sponging hsa-miR-660-5p, thereby increasing ETV1 expression. This circRNA_miRNA interaction and downstream effect were supported by luciferase assays and overexpression/miRNA inhibition experiments."	0.5803
30504757	Medical science monitor : international medical journal of experimental and clinical research	2018	High-Throughput Sequencing Strategy for miR-146b-regulated circRNA Expression in Hepatic Stellate Cells.		rno-circRNA-469			hepatic fibrosis 	MONDO:0100430	fibrotic liver disease	down-regulated	RT-qPCR; RNA-seq	rno-circRNA-469 is downregulated after miR-146b knockdown in HSC-T6 cells and is suggested to have a similar role to miR-146b in modulating hepatic stellate cells in the context of liver fibrosis.	0.3684
30504757	Medical science monitor : international medical journal of experimental and clinical research	2018	High-Throughput Sequencing Strategy for miR-146b-regulated circRNA Expression in Hepatic Stellate Cells.		rno-circRNA-1138			hepatic fibrosis 	MONDO:0100430	fibrotic liver disease	down-regulated	RT-qPCR; RNA-seq	rno-circRNA-1138 is downregulated after miR-146b knockdown in HSC-T6 cells and is proposed to act in a similar direction to miR-146b in regulating HSCs relevant to liver fibrosis.	0.3684
30504757	Medical science monitor : international medical journal of experimental and clinical research	2018	High-Throughput Sequencing Strategy for miR-146b-regulated circRNA Expression in Hepatic Stellate Cells.		rno-circRNA-2168			hepatic fibrosis 	MONDO:0100430	fibrotic liver disease	down-regulated	RT-qPCR; RNA-seq	"rno-circRNA-2168 is decreased upon miR-146b knockdown in HSC-T6 cells and is suggested to participate with miR-146b in regulating HSC-related fibrotic processes, though no specific downstream targets are provided."	0.3684
30504757	Medical science monitor : international medical journal of experimental and clinical research	2018	High-Throughput Sequencing Strategy for miR-146b-regulated circRNA Expression in Hepatic Stellate Cells.		rno-circRNA-1907			hepatic fibrosis 	MONDO:0100430	fibrotic liver disease	down-regulated	RT-qPCR; RNA-seq	rno-circRNA-1907 (also written as rno-circRAN-1907) is downregulated after miR-146b knockdown in HSC-T6 cells and is suggested to function in the same direction as miR-146b during HSC modulation relevant to liver fibrosis.	0.3684
30504757	Medical science monitor : international medical journal of experimental and clinical research	2018	High-Throughput Sequencing Strategy for miR-146b-regulated circRNA Expression in Hepatic Stellate Cells.		rno-circRNA-1984			hepatic fibrosis 	MONDO:0100430	fibrotic liver disease	up-regulated	RT-qPCR; RNA-seq	rno-circRNA-1984/circRNA-1984 is upregulated after miR-146b knockdown in HSC-T6 cells and is proposed to act opposite to miR-146b in modulating hepatic stellate cell behavior relevant to liver fibrosis.	0.3684
30506951	Journal of cellular biochemistry	2019	Circular RNA hsa_circ_0076248 promotes oncogenesis of glioma by sponging miR-181a to modulate SIRT1 expression.	hsa_circ_0076248		hsa_circ_ZFAND3	ZFAND3	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR	"hsa_circ_0076248 is up-regulated in glioma/GBM tissues and cell lines and promotes oncogenic phenotypes (proliferation, migration/invasion) and temozolomide resistance. Mechanistically, it functions as a miR-181a sponge to regulate the miR-181a/SIRT1 axis and affects p53 and SIRT1 protein levels."	0.5762
30507050	Cell proliferation	2019	Circ_0078767 suppresses non-small-cell lung cancer by protecting RASSF1A expression via sponging miR-330-3p.	hsa_circ_0078767				non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"circ_0078767 is down-regulated in NSCLC tissues and cell lines and suppresses malignant phenotypes. It sponges miR-330-3p to increase RASSF1A expression, thereby inhibiting proliferation/invasion, promoting apoptosis, and reducing xenograft tumour growth."	0.7756
30510446	Cancer management and research	2018	Circ-SFMBT2 promotes the proliferation of gastric cancer cells through sponging miR-182-5p to enhance CREB1 expression.	hsa_circ_0017639	circ-SFMBT2	hsa_circ_SFMBT2	SFMBT2	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circ-SFMBT2 is up-regulated in gastric cancer tissues and plasma and promotes gastric cancer cell proliferation. Mechanistically, it mainly localizes in the cytoplasm and functions as a ceRNA by sponging miR-182-5p to enhance CREB1 expression (circ-SFMBT2/miR-182-5p/CREB1 axis), with diagnostic potential supported by ROC analysis."	0.8686
30514309	Molecular cancer	2018	CircFAT1 sponges miR-375 to promote the expression of Yes-associated protein 1 in osteosarcoma cells.		circFAT1	hsa_circ_FAT1	FAT1	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Northern Blot; ISH	"circFAT1 is up-regulated in osteosarcoma tissues and cell lines and is mainly localized in the cytoplasm. It promotes osteosarcoma cell proliferation, migration, invasion and tumorigenesis by sponging miR-375, thereby increasing YAP1 expression (with effects on c-Myc and Birc5) and linking to Hippo/YAP signaling."	0.8781
30519852	Digestive diseases and sciences	2019	Circ-TTC17 Promotes Proliferation and Migration of Esophageal Squamous Cell Carcinoma.		circ-TTC17	hsa_circ_TTC17	TTC17	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circ-TTC17 is up-regulated in ESCC plasma, tumor tissues and ESCC cell lines, and its knockdown suppresses proliferation and migration in KYSE30/KYSE450 cells. It is mainly cytoplasmic and is proposed (by bioinformatic prediction and AGO2 occupancy) to act as a miRNA sponge, forming a putative circRNA_miRNA_mRNA network. High circ-TTC17 level in plasma shows diagnostic potential and is associated with shorter overall survival."	0.8277
30520539	Cancer science	2019	circLARP4 induces cellular senescence through regulating miR-761/RUNX3/p53/p21 signaling in hepatocellular carcinoma.		circLARP4	hsa_circ_LARP4	LARP4	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"circLARP4 is downregulated in HCC and functions as a tumor suppressor by inducing cellular senescence and G1/S arrest and inhibiting proliferation. Mechanistically, it sponges miR-761 to upregulate RUNX3 and activate the p53/p21 senescence program. Low circLARP4 expression is associated with worse survival outcomes."	0.8497
30524667	Computational and structural biotechnology journal	2018	Identification of Differentially Expressed Profiles of Alzheimer's Disease Associated Circular RNAs in a Panax Notoginseng Saponins-Treated Alzheimer's Disease Mouse Model.		mmu_circRNA_013636	mmu_circ_Trpc6	Trpc6	Alzheimer's disease 	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR; Microarray	"mmu_circRNA_013636 (Trpc6-derived) was significantly up-regulated in PNS-untreated SAMP8 hippocampus compared with PNS-treated mice and was further analyzed by predicted circRNA-miRNA-mRNA networks and GO/KEGG enrichment, suggesting involvement in AD-related processes/pathways."	0.3684
30524667	Computational and structural biotechnology journal	2018	Identification of Differentially Expressed Profiles of Alzheimer's Disease Associated Circular RNAs in a Panax Notoginseng Saponins-Treated Alzheimer's Disease Mouse Model.		mmu_circRNA_012180	mmu_circ_Phkb	Phkb	Alzheimer's disease 	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_012180 (Phkb-derived) was significantly down-regulated in PNS-untreated SAMP8 hippocampus compared with PNS-treated mice and was further analyzed by predicted circRNA-miRNA-mRNA networks and GO/KEGG enrichment, suggesting possible involvement in AD-related processes/pathways."	0.3684
30524667	Computational and structural biotechnology journal	2018	Identification of Differentially Expressed Profiles of Alzheimer's Disease Associated Circular RNAs in a Panax Notoginseng Saponins-Treated Alzheimer's Disease Mouse Model.		mmu_circRNA_006173			Alzheimer's disease 	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_006173 was validated by RT-qPCR as significantly down-regulated in PNS-untreated SAMP8 hippocampus compared with PNS-treated mice, indicating PNS modulates its expression in this AD mouse model."	0.3213
30524667	Computational and structural biotechnology journal	2018	Identification of Differentially Expressed Profiles of Alzheimer's Disease Associated Circular RNAs in a Panax Notoginseng Saponins-Treated Alzheimer's Disease Mouse Model.		mmu_circRNA_001456			Alzheimer's disease 	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_001456 was validated by RT-qPCR as significantly down-regulated in PNS-untreated SAMP8 hippocampus compared with PNS-treated mice, indicating PNS modulates its expression in this AD mouse model."	0.3213
30524667	Computational and structural biotechnology journal	2018	Identification of Differentially Expressed Profiles of Alzheimer's Disease Associated Circular RNAs in a Panax Notoginseng Saponins-Treated Alzheimer's Disease Mouse Model.		mmu_circRNA_006229			Alzheimer's disease 	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR; Microarray	"mmu_circRNA_006229 was validated by RT-qPCR as significantly up-regulated in PNS-untreated SAMP8 hippocampus compared with PNS-treated mice, indicating PNS modulates its expression in this AD mouse model."	0.3213
30524667	Computational and structural biotechnology journal	2018	Identification of Differentially Expressed Profiles of Alzheimer's Disease Associated Circular RNAs in a Panax Notoginseng Saponins-Treated Alzheimer's Disease Mouse Model.		mmu_circRNA_003540			Alzheimer's disease 	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_003540 was validated by RT-qPCR as significantly down-regulated in PNS-untreated SAMP8 hippocampus compared with PNS-treated mice, indicating PNS modulates its expression in this AD mouse model."	0.3213
30524667	Computational and structural biotechnology journal	2018	Identification of Differentially Expressed Profiles of Alzheimer's Disease Associated Circular RNAs in a Panax Notoginseng Saponins-Treated Alzheimer's Disease Mouse Model.		mmu_circRNA_000692			Alzheimer's disease 	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_000692 was validated by RT-qPCR as significantly down-regulated in PNS-untreated SAMP8 hippocampus compared with PNS-treated mice, indicating PNS modulates its expression in this AD mouse model."	0.3213
30531834	Oncogene	2019	Dysregulation of p53-RBM25-mediated circAMOTL1L biogenesis contributes to prostate cancer progression through the circAMOTL1L-miR-193a-5p-Pcdha pathway.		hsa_circRNA_000350	hsa_circ_AMOTL1	AMOTL1	prostate cancer 	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; Northern Blot; ISH; Microarray	"circAMOTL1L is down-regulated in prostate cancer and functions as a tumor-suppressive circRNA by inhibiting EMT-associated migration and invasion. It mainly acts as a cytoplasmic ceRNA that sponges miR-193a-5p to de-repress Pcdha (especially Pcdha8), and its biogenesis is promoted by RBM25 under p53 transcriptional control."	0.8048
30537115	Molecular oncology	2019	Circular RNA profiling identifies circADAMTS13 as a miR-484 sponge which suppresses cell proliferation in hepatocellular carcinoma.		circADAMTS13 / hsa_circ:chr9:136302869-136303486	hsa_circ_ADAMTS13	ADAMTS13	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"circADAMTS13 is down-regulated in HCC tumor tissues and functions as a tumor suppressor by inhibiting HCC cell proliferation and promoting apoptosis. Mechanistically, it directly binds (sponges) miR-484, and miR-484 mimics can rescue the suppressive phenotype. Clinically, low circADAMTS13 is associated with larger tumor size and shorter RFS."	0.8405
30537115	Molecular oncology	2019	Circular RNA profiling identifies circADAMTS13 as a miR-484 sponge which suppresses cell proliferation in hepatocellular carcinoma.		circDPF3 / hsa_circ:chr14:73181131-73198642	hsa_circ_DPF3	DPF3	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"circDPF3 is significantly down-regulated in HCC tumor tissues versus matched peritumor tissues and healthy liver tissues, and it may be involved in HCC progression. The study did not further validate a mechanism or functional role for circDPF3 beyond expression/diagnostic analyses."	0.6238
30537986	Genome biology	2018	A novel FLI1 exonic circular RNA promotes metastasis in breast cancer by coordinately regulating TET1 and DNMT1.		FECR1 / FLI1 exonic circular RNA / FLI1 circular RNA / FLI1 circular RNA FECR1	hsa_circ_FLI1	FLI1	breast cancer 	MONDO:0007254	breast cancer	unknown	RT-qPCR	"FECR1 (an exonic circRNA from FLI1) promotes invasion/metastasis in breast cancer cells. Mechanistically, it binds the FLI1 promoter and recruits TET1 to induce CpG demethylation, while also repressing DNMT1, resulting in increased FLI1 expression via an epigenetic positive-feedback loop."	0.8191
30540564	Aging	2018	Circular RNA EIF6 (Hsa_circ_0060060) sponges miR-144-3p to promote the cisplatin-resistance of human thyroid carcinoma cells by autophagy regulation.	hsa_circ_0060060	circEIF6	hsa_circ_EIF6	EIF6	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"This study reports that circEIF6 (hsa_circ_0060060) is upregulated in thyroid carcinoma and promotes cisplatin resistance. Mechanistically, circEIF6 sponges miR-144-3p to increase TGF-alpha expression, thereby enhancing autophagy and inhibiting apoptosis in PTC/ATC cells, and circEIF6 knockdown increases cisplatin sensitivity in a BHT101 xenograft model."	0.7756
30542712	Oncology reports	2019	A two_circRNA signature predicts tumour recurrence in clinical non_functioning pituitary adenoma.	hsa_circ_0000066	hsa_circ_0000066b	hsa_circ_RNF220	RNF220	non-functioning pituitary adenoma 	MONDO:0019613	non-functioning pituitary adenoma	unknown	Microarray	"hsa_circ_0000066 (RNF220-derived) is one component of a two-circRNA prognostic signature for NFPA that stratifies patients into high- and low-risk recurrence/progression groups with different PFS. Mechanistically, the study provides bioinformatics evidence suggesting co-expression-based functional links to vesicle transport and unfolded-protein response processes, and reports a predicted binding relationship with hsa_circ_0069707."	0.5121
30542712	Oncology reports	2019	A two_circRNA signature predicts tumour recurrence in clinical non_functioning pituitary adenoma.	hsa_circ_0069707	hsa_circ_0069707b	hsa_circ_FRYL	FRYL	non-functioning pituitary adenoma 	MONDO:0019613	non-functioning pituitary adenoma	unknown	Microarray	"hsa_circ_0069707 (FRYL-derived) is one component of a two-circRNA prognostic signature for NFPA that predicts recurrence/progression risk and is associated with PFS. The study provides bioinformatics evidence linking the signature to vesicle-transport and unfolded-protein-response related processes, and reports a predicted binding relationship with hsa_circ_0000066."	0.5121
30546088	Oncogene	2019	Exosome circRNA secreted from adipocytes promotes the growth of hepatocellular carcinoma by targeting deubiquitination-related USP7.	hsa_circ_0025129		hsa_circ_TNFRSF1A	TNFRSF1A	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"Exosomal circ-DB (hsa_circ_0025129, from TNFRSF1A) is upregulated in HCC patients with higher body fat ratio. It promotes HCC proliferation/migration/metastasis and reduces DNA damage by sponging miR-34a, thereby increasing USP7 and activating the USP7/Cyclin A2 deubiquitination signaling axis."	0.7756
30558617	Journal of translational medicine	2018	Circular RNA regulatory network reveals cell-cell crosstalk in acute myeloid leukemia extramedullary infiltration.	hsa_circ_0004520		hsa_circ_VAV2	VAV2	acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; Microarray	"hsa_circ_0004520 (VAV2-derived) is up-regulated in EMI compared with non-EMI AML BMMCs and was RT-qPCR validated. The study proposes it may participate in EMI-related cell_cell crosstalk via a predicted circRNA/miRNA/mRNA network and highlights PLXNB2 and VEGFA as downstream target genes, but functional mechanisms were not experimentally confirmed."	0.4032
30566420	Medical science monitor : international medical journal of experimental and clinical research	2018	Expression Profile Analysis of Circular RNAs in Ovarian Endometriosis by Microarray and Bioinformatics.	hsa_circ_0067301	circ_103470			ovarian endometriosis 	MONDO:0006337	ovarian endometriosis	down-regulated	RT-qPCR; Microarray	circ_103470 is down-regulated in endometriosis and was validated by qRT-PCR to match the microarray result. The study suggests it may regulate epithelial-mesenchymal transition in endometriosis via a ceRNA mechanism involving miR-141-5p.	0.4032
30566420	Medical science monitor : international medical journal of experimental and clinical research	2018	Expression Profile Analysis of Circular RNAs in Ovarian Endometriosis by Microarray and Bioinformatics.	hsa_circ_0000419		hsa_circ_RAB3IP	RAB3IP	ovarian endometriosis 	MONDO:0006337	ovarian endometriosis	down-regulated	RT-qPCR; Microarray	"circ_101102 (derived from RAB3IP) is down-regulated in endometriosis and its differential expression was validated by qRT-PCR. The study proposes it may regulate epithelial-mesenchymal transition via miR-141-5p in a ceRNA network, and discusses a possible link to autophagy in endometriosis."	0.4032
30570107	International journal of oncology	2019	"Potential ceRNA networks involved in autophagy suppression of pancreatic cancer caused by chloroquine diphosphate: A study based on differentially_expressed circRNAs, lncRNAs, miRNAs and mRNAs."	hsa_circ_0003176				pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	Microarray	hsa_circ_0003176 was identified by microarray as an upregulated circRNA after chloroquine diphosphate-induced autophagy inhibition in PANC-1 pancreatic cancer cells and was included as a predicted ceRNA targeting (sponging) hsa-miR-663a-5p in the constructed network.	0.1768
30570107	International journal of oncology	2019	"Potential ceRNA networks involved in autophagy suppression of pancreatic cancer caused by chloroquine diphosphate: A study based on differentially_expressed circRNAs, lncRNAs, miRNAs and mRNAs."	hsa_circ_0048579				pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	Microarray	hsa_circ_0048579 was identified as an upregulated circRNA after chloroquine diphosphate-induced autophagy inhibition in PANC-1 pancreatic cancer cells and was included in a predicted ceRNA network as a miR-663a-5p-targeting circRNA.	0.1768
30570107	International journal of oncology	2019	"Potential ceRNA networks involved in autophagy suppression of pancreatic cancer caused by chloroquine diphosphate: A study based on differentially_expressed circRNAs, lncRNAs, miRNAs and mRNAs."	hsa_circ_0063706				pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	Microarray	hsa_circ_0063706 was identified as an upregulated circRNA after chloroquine diphosphate-mediated autophagy inhibition in PANC-1 pancreatic cancer cells and was incorporated into a predicted miR-663a-5p-centered ceRNA network.	0.1768
30570107	International journal of oncology	2019	"Potential ceRNA networks involved in autophagy suppression of pancreatic cancer caused by chloroquine diphosphate: A study based on differentially_expressed circRNAs, lncRNAs, miRNAs and mRNAs."	hsa_circ_0071922				pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	Microarray	hsa_circ_0071922 was upregulated after chloroquine diphosphate-induced autophagy suppression in PANC-1 cells and was predicted as a ceRNA with the highest number of miR-663a-5p binding sites (six) within the constructed network.	0.1768
30570107	International journal of oncology	2019	"Potential ceRNA networks involved in autophagy suppression of pancreatic cancer caused by chloroquine diphosphate: A study based on differentially_expressed circRNAs, lncRNAs, miRNAs and mRNAs."	hsa_circ_0078989				pancreatic cancer	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	Microarray	hsa_circ_0078989 was upregulated in chloroquine diphosphate-treated PANC-1 cells (autophagy suppression) and was predicted to target miR-663a-5p as part of an autophagy-associated ceRNA network.	0.1768
30570107	International journal of oncology	2019	"Potential ceRNA networks involved in autophagy suppression of pancreatic cancer caused by chloroquine diphosphate: A study based on differentially_expressed circRNAs, lncRNAs, miRNAs and mRNAs."	hsa_circ_0079319				pancreatic cancer	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	Microarray	hsa_circ_0079319 was upregulated after autophagy inhibition by chloroquine diphosphate in PANC-1 cells and was predicted to bind miR-663a-5p as part of a ceRNA network linked to autophagy in pancreatic cancer cells.	0.1768
30570107	International journal of oncology	2019	"Potential ceRNA networks involved in autophagy suppression of pancreatic cancer caused by chloroquine diphosphate: A study based on differentially_expressed circRNAs, lncRNAs, miRNAs and mRNAs."	hsa_circ_0083080				pancreatic cancer	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	Microarray	hsa_circ_0083080 was upregulated after chloroquine diphosphate-induced autophagy inhibition in PANC-1 cells and was predicted to bind miR-663a-5p as a component of the autophagy-associated ceRNA network.	0.1768
30570107	International journal of oncology	2019	"Potential ceRNA networks involved in autophagy suppression of pancreatic cancer caused by chloroquine diphosphate: A study based on differentially_expressed circRNAs, lncRNAs, miRNAs and mRNAs."	hsa_circ_0089643				pancreatic cancer	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	Microarray	hsa_circ_0089643 was upregulated following chloroquine diphosphate-induced autophagy suppression in PANC-1 cells and was predicted to target miR-663a-5p within an autophagy-associated ceRNA network.	0.1768
30570107	International journal of oncology	2019	"Potential ceRNA networks involved in autophagy suppression of pancreatic cancer caused by chloroquine diphosphate: A study based on differentially_expressed circRNAs, lncRNAs, miRNAs and mRNAs."	hsa_circ_0090372				pancreatic cancer	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	Microarray	hsa_circ_0090372 was upregulated after chloroquine diphosphate-induced autophagy inhibition in PANC-1 cells and was predicted to bind miR-663a-5p within the constructed autophagy-associated ceRNA network.	0.1768
30570107	International journal of oncology	2019	"Potential ceRNA networks involved in autophagy suppression of pancreatic cancer caused by chloroquine diphosphate: A study based on differentially_expressed circRNAs, lncRNAs, miRNAs and mRNAs."	hsa_circ_0000156				pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	Microarray	hsa_circ_0000156 was upregulated after chloroquine diphosphate-mediated autophagy suppression in PANC-1 cells and was predicted to bind miR-154-3p (two binding sites) as part of a miR-154-3p-centered ceRNA network.	0.1768
30570107	International journal of oncology	2019	"Potential ceRNA networks involved in autophagy suppression of pancreatic cancer caused by chloroquine diphosphate: A study based on differentially_expressed circRNAs, lncRNAs, miRNAs and mRNAs."	hsa_circ_0004089				pancreatic cancer	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	Microarray	hsa_circ_0004089 was upregulated after chloroquine diphosphate-induced autophagy suppression in PANC-1 cells and was predicted to bind miR-154-3p (two binding sites) as part of the miR-154-3p ceRNA network.	0.1768
30570107	International journal of oncology	2019	"Potential ceRNA networks involved in autophagy suppression of pancreatic cancer caused by chloroquine diphosphate: A study based on differentially_expressed circRNAs, lncRNAs, miRNAs and mRNAs."	hsa_circ_0006461				pancreatic cancer	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	Microarray	hsa_circ_0006461 was upregulated after chloroquine diphosphate-induced autophagy suppression in PANC-1 cells and was predicted to bind miR-154-3p (two binding sites) in the constructed ceRNA network.	0.1768
30570107	International journal of oncology	2019	"Potential ceRNA networks involved in autophagy suppression of pancreatic cancer caused by chloroquine diphosphate: A study based on differentially_expressed circRNAs, lncRNAs, miRNAs and mRNAs."	hsa_circ_0015157				pancreatic cancer	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	Microarray	hsa_circ_0015157 was upregulated after chloroquine diphosphate-induced autophagy suppression in PANC-1 cells and was predicted to bind miR-154-3p (two binding sites) as a component of the miR-154-3p ceRNA network.	0.1768
30570107	International journal of oncology	2019	"Potential ceRNA networks involved in autophagy suppression of pancreatic cancer caused by chloroquine diphosphate: A study based on differentially_expressed circRNAs, lncRNAs, miRNAs and mRNAs."	hsa_circ_0038665				pancreatic cancer	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	Microarray	hsa_circ_0038665 was upregulated after chloroquine diphosphate-induced autophagy suppression in PANC-1 cells and was predicted to bind miR-154-3p (two binding sites) within the constructed ceRNA network.	0.1768
30576282	Endocrine-related cancer	2019	"Novel circular RNA circNF1 acts as a molecular sponge, promoting gastric cancer by absorbing miR-16."	hsa_circ_0042881	circNF1	hsa_circ_NF1	NF1	gastric carcinoma 	MONDO:0004950	gastric carcinoma	up-regulated	RT-qPCR; RNA-seq	"circNF1 (hsa_circ_0042881), derived from NF1 exons 2-8, is up-regulated in gastric carcinoma tissues and GC cell lines. It promotes malignant phenotypes (proliferation and migration) and reduces apoptosis by sponging miR-16, thereby increasing MAP7 and AKT3 translation and enhancing AKT pathway activity."	0.8052
30576282	Endocrine-related cancer	2019	"Novel circular RNA circNF1 acts as a molecular sponge, promoting gastric cancer by absorbing miR-16."		circMYH9	hsa_circ_MYH9	MYH9	gastric carcinoma 	MONDO:0004950	gastric carcinoma	down-regulated	RT-qPCR	"circMYH9 (from MYH9 exons 39-40, antisense strand) was identified and sequence-validated as an exonic circRNA and is down-regulated in gastric cancer cell lines compared with HFE145; no functional or mechanistic follow-up was performed in this study."	0.4358
30587718	Anatolian journal of cardiology	2019	Circular RNA expression profiles of persistent atrial fibrillation in patients with rheumatic heart disease.		circRNA_20118	hsa_circ_C9orf84	C9orf84	persistent atrial fibrillation 	MONDO:1030009	persistent atrial fibrillation	up-regulated	RT-qPCR; RNA-seq	"circRNA_20118 is up-regulated in left atrial appendage tissue from patients with persistent AF due to rheumatic heart disease versus non-AF controls, supported by RNA-seq and validated by qRT-PCR and Sanger sequencing."	0.4773
30587718	Anatolian journal of cardiology	2019	Circular RNA expression profiles of persistent atrial fibrillation in patients with rheumatic heart disease.		circRNA_17558	hsa_circ_RNF216	RNF216	persistent atrial fibrillation 	MONDO:1030009	persistent atrial fibrillation	up-regulated	RT-qPCR; RNA-seq	"circRNA_17558 is up-regulated in left atrial appendage tissue from patients with persistent AF due to rheumatic heart disease versus non-AF controls, supported by RNA-seq and validated by qRT-PCR and Sanger sequencing."	0.4773
30587718	Anatolian journal of cardiology	2019	Circular RNA expression profiles of persistent atrial fibrillation in patients with rheumatic heart disease.		circRNA_16688	hsa_circ_MLIP	MLIP	persistent atrial fibrillation 	MONDO:1030009	persistent atrial fibrillation	up-regulated	RT-qPCR; RNA-seq	"circRNA_16688 is up-regulated in left atrial appendage tissue from patients with persistent AF due to rheumatic heart disease versus non-AF controls, supported by RNA-seq and validated by qRT-PCR and Sanger sequencing."	0.4773
30587718	Anatolian journal of cardiology	2019	Circular RNA expression profiles of persistent atrial fibrillation in patients with rheumatic heart disease.		circRNA_11109	hsa_circ_TTN	TTN	persistent atrial fibrillation 	MONDO:1030009	persistent atrial fibrillation	down-regulated	RT-qPCR; RNA-seq	circRNA_11109 (host gene TTN) is down-regulated in AF atrial tissue and is predicted (miRanda/network analysis) to interact with hsa-miR-29b-1-5p and hsa-miR-29b-2-5p as part of a circRNA_miRNA network potentially relevant to AF remodeling.	0.5135
30587718	Anatolian journal of cardiology	2019	Circular RNA expression profiles of persistent atrial fibrillation in patients with rheumatic heart disease.		circRNA_11017	hsa_circ_TTN	TTN	persistent atrial fibrillation 	MONDO:1030009	persistent atrial fibrillation	down-regulated	RT-qPCR; RNA-seq	circRNA_11017 (host gene TTN) is down-regulated in AF atrial tissue and is predicted to interact with hsa-miR-29b-1-5p and hsa-miR-29b-2-5p within a circRNA_miRNA network potentially involved in AF-related structural remodeling.	0.5135
30587718	Anatolian journal of cardiology	2019	Circular RNA expression profiles of persistent atrial fibrillation in patients with rheumatic heart disease.		circRNA_11058	hsa_circ_TTN	TTN	persistent atrial fibrillation 	MONDO:1030009	persistent atrial fibrillation	down-regulated	RT-qPCR; RNA-seq	circRNA_11058 (host gene TTN) is down-regulated in AF atrial tissue and is predicted to interact with hsa-miR-29b-1-5p and hsa-miR-29b-2-5p as part of a circRNA_miRNA network implicated in AF pathogenesis.	0.5135
30587718	Anatolian journal of cardiology	2019	Circular RNA expression profiles of persistent atrial fibrillation in patients with rheumatic heart disease.		circRNA19591			persistent atrial fibrillation 	MONDO:1030009	persistent atrial fibrillation	down-regulated	RNA-seq	"circRNA19591 is down-regulated in AF atrial tissue and occupies a core position in the predicted circRNA_miRNA co-expression network, interacting with 36 miRNAs, suggesting a potential regulatory role in AF pathogenesis."	0.348
30587718	Anatolian journal of cardiology	2019	Circular RNA expression profiles of persistent atrial fibrillation in patients with rheumatic heart disease.		circRNA19596			persistent atrial fibrillation 	MONDO:1030009	persistent atrial fibrillation	down-regulated	RNA-seq	"circRNA19596 is down-regulated in AF atrial tissue and is a core node in the predicted circRNA_miRNA network, interacting with 28 miRNAs, indicating a potential role in miRNA-associated regulation in AF."	0.348
30587718	Anatolian journal of cardiology	2019	Circular RNA expression profiles of persistent atrial fibrillation in patients with rheumatic heart disease.		circRNA16175			persistent atrial fibrillation 	MONDO:1030009	persistent atrial fibrillation	down-regulated	RNA-seq	"circRNA16175 is down-regulated in AF atrial tissue and is included as a key node in the predicted circRNA_miRNA network, interacting with 18 miRNAs, suggesting a potential regulatory role via miRNA interactions in AF."	0.348
30591054	Journal of experimental & clinical cancer research : CR	2018	RNA sequencing reveals the expression profiles of circRNA and indicates that circDDX17 acts as a tumor suppressor in colorectal cancer.	hsa_circ_0002211	circDDX17	hsa_circ_DDX17	DDX17	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"circDDX17 (hsa_circ_0002211), derived from the DDX17 gene, is significantly down-regulated in colorectal cancer tissues and is associated with aggressive clinicopathological features. Functional assays show that circDDX17 suppresses CRC cell proliferation, migration and invasion while promoting apoptosis. Mechanistically, it is predicted to sponge hsa-miR-21-5p, but downstream targets were not experimentally confirmed."	0.657
30598042	Cells	2018	A Role for Circular Non-Coding RNAs in the Pathogenesis of Sporadic Parathyroid Adenomas and the Impact of Gender-Specific Epigenetic Regulation.	hsa_circ_0051778	hsa-CircRNA_051778	hsa_circ_BCAT2	BCAT2	sporadic parathyroid adenomas 	MONDO:0006890	parathyroid gland adenoma	up-regulated	RT-qPCR; Microarray	This circRNA is significantly up-regulated in sporadic parathyroid adenomas versus normal parathyroid tissue based on microarray profiling and was among the top fold-change candidates selected for qRT-PCR validation.	0.5135
30598042	Cells	2018	A Role for Circular Non-Coding RNAs in the Pathogenesis of Sporadic Parathyroid Adenomas and the Impact of Gender-Specific Epigenetic Regulation.	hsa_circ_0005622	hsa-CircRNA_406174	hsa_circ_PITPNB	PITPNB	sporadic parathyroid adenomas 	MONDO:0006890	parathyroid gland adenoma	up-regulated	RT-qPCR; Microarray	"hsa-CircRNA_406174 is strongly up-regulated in sporadic parathyroid adenomas versus normal parathyroid tissue and has predicted binding to multiple miRNAs (including hsa-miR_1248), suggesting a potential ceRNA/miRNA-sponge role."	0.5135
30598042	Cells	2018	A Role for Circular Non-Coding RNAs in the Pathogenesis of Sporadic Parathyroid Adenomas and the Impact of Gender-Specific Epigenetic Regulation.	hsa_circ_0008267	hsa-CircRNA_008267	hsa_circ_LINC00969		sporadic parathyroid adenomas 	MONDO:0006890	parathyroid gland adenoma	up-regulated	RT-qPCR; Microarray	This circRNA is among the most strongly up-regulated circRNAs in sporadic parathyroid adenomas compared with normal parathyroid tissue and was included among the top candidates for qRT-PCR validation.	0.5135
30598042	Cells	2018	A Role for Circular Non-Coding RNAs in the Pathogenesis of Sporadic Parathyroid Adenomas and the Impact of Gender-Specific Epigenetic Regulation.	hsa_circ_0032603	hsa-CircRNA_032603	hsa_circ_LTBP2	LTBP2	sporadic parathyroid adenomas 	MONDO:0006890	parathyroid gland adenoma	down-regulated	RT-qPCR; Microarray	"hsa-CircRNA_032603 is significantly down-regulated in sporadic parathyroid adenomas compared to normal parathyroid tissue and has predicted miRNA binding sites (including hsa-miR_486-3p), consistent with a potential ceRNA role."	0.5135
30598042	Cells	2018	A Role for Circular Non-Coding RNAs in the Pathogenesis of Sporadic Parathyroid Adenomas and the Impact of Gender-Specific Epigenetic Regulation.	hsa_circ_0058097	hsa-CircRNA_058097	hsa_circ_FN1	FN1	sporadic parathyroid adenomas 	MONDO:0006890	parathyroid gland adenoma	down-regulated	RT-qPCR; Microarray	"hsa-CircRNA_058097 is significantly down-regulated in sporadic parathyroid adenomas versus normal parathyroid tissue and has predicted miRNA binding sites, suggesting it may participate in miRNA-mediated regulatory networks in PA."	0.5135
30598042	Cells	2018	A Role for Circular Non-Coding RNAs in the Pathogenesis of Sporadic Parathyroid Adenomas and the Impact of Gender-Specific Epigenetic Regulation.	hsa_circ_0140094	hsa-CircRNA_404337	hsa_circ_RPS6KA3	RPS6KA3	sporadic parathyroid adenomas 	MONDO:0006890	parathyroid gland adenoma	up-regulated	Microarray	hsa-CircRNA_404337 is up-regulated in sporadic parathyroid adenomas and is predicted (bioinformatically) to bind several miRNAs and to interact with CDKN1B-related gene networks implicated in PA pathogenesis.	0.4685
30598042	Cells	2018	A Role for Circular Non-Coding RNAs in the Pathogenesis of Sporadic Parathyroid Adenomas and the Impact of Gender-Specific Epigenetic Regulation.		hsa-CircRNA_402533	hsa_circ_OVOL2	OVOL2	sporadic parathyroid adenomas 	MONDO:0006890	parathyroid gland adenoma	up-regulated	Microarray	"Although identified as highly up-regulated by microarray in sporadic parathyroid adenomas, this circRNA was the only top candidate whose differential expression was not confirmed by qRT-PCR in the same sample set."	0.4685
30613267	Theranostics	2018	A circular transcript of ncx1 gene mediates ischemic myocardial injury by targeting miR-133a-3p.		circNCX1	mmu_circ_Ncx1	ncx1	ischemic myocardial injury 	MONDO:0024644	myocardial ischemia	up-regulated	RT-qPCR	"circNCX1 is up-regulated under oxidative stress and myocardial ischemia/I-R injury, and it promotes cardiomyocyte apoptosis. Mechanistically, it functions as a ceRNA sponge for miR-133a-3p, relieving miR-133a-3p repression of CDIP1 and increasing CDIP1 levels; circNCX1 knockdown attenuates apoptosis and myocardial I/R damage in mice."	0.7817
30613267	Theranostics	2018	A circular transcript of ncx1 gene mediates ischemic myocardial injury by targeting miR-133a-3p.		circNCX1	rno_circ_Ncx1	ncx1	ischemic myocardial injury 	MONDO:0024644	myocardial ischemia	up-regulated	RT-qPCR	"circNCX1 is up-regulated under oxidative stress and myocardial ischemia/I-R injury, and it promotes cardiomyocyte apoptosis. Mechanistically, it functions as a ceRNA sponge for miR-133a-3p, relieving miR-133a-3p repression of CDIP1 and increasing CDIP1 levels; circNCX1 knockdown attenuates apoptosis and myocardial I/R damage in mice."	0.7817
30621700	Molecular cancer	2019	The circRNA circAGFG1 acts as a sponge of miR-195-5p to promote triple-negative breast cancer progression through regulating CCNE1 expression.	hsa_circ_0058514	circAGFG1	hsa_circ_AGFG1	AGFG1	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circAGFG1 (hsa_circ_0058514), derived from AGFG1, is up-regulated in TNBC and promotes proliferation, migration/invasion, tumor growth, angiogenesis and lung metastasis while inhibiting apoptosis. It acts mainly in the cytoplasm as a ceRNA sponging miR-195-5p to de-repress CCNE1, driving cell-cycle progression. High circAGFG1 expression is associated with advanced clinicopathological features and poor overall survival, and shows diagnostic potential by ROC analysis."	0.8793
30621721	Journal of experimental & clinical cancer research : CR	2019	MOV10 binding circ-DICER1 regulates the angiogenesis of glioma via miR-103a-3p/miR-382-5p mediated ZIC4 expression change.	hsa_circ_0033079		hsa_circ_DICER1	DICER1	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ-DICER1 is up-regulated in glioma-exposed endothelial cells and promotes angiogenesis-related behaviors (viability, migration, tube formation). Mechanistically, MOV10 binds circ-DICER1, and circ-DICER1 sponges miR-103a-3p/miR-382-5p to derepress ZIC4, leading to increased Hsp90beta and activation of PI3K/AKT signaling."	0.6945
30623853	Molecular therapy. Nucleic acids	2019	circARF3 Alleviates Mitophagy-Mediated Inflammation by Targeting miR-103/TRAF3 in Mouse Adipose Tissue.	mmu_circ_0000650		mmu_circ_ARF3	ARF3	obesity disorder 	MONDO:0011122	obesity disorder	down-regulated	RT-qPCR	"In obese/inflamed mouse adipose tissue, circARF3 (circ0000650, from ARF3) is down-regulated and functions as a ceRNA sponge for miR-103. By sequestering miR-103, it relieves repression of TRAF3, inhibits NF-kappaB signaling and NLRP3 inflammasome activation, enhances mitophagy, and overall alleviates adipose inflammation in vitro and in vivo."	0.717
30630466	Molecular cancer	2019	RNA-Seq profiling of circular RNAs in human colorectal Cancer liver metastasis and the potential biomarkers.	hsa_circ_0001178				colorectal cancer liver metastases 	MONDO:0021063	malignant colon neoplasm	up-regulated	RT-qPCR; RNA-seq	"circRNA_0001178 is significantly up-regulated in colorectal cancer with liver metastasis (CRC-m) compared with CRC without liver metastasis. It shows strong diagnostic potential for distinguishing CRC-m from CRC, and the study constructed a predicted circRNA-miRNA-mRNA network around it."	0.5047
30630466	Molecular cancer	2019	RNA-Seq profiling of circular RNAs in human colorectal Cancer liver metastasis and the potential biomarkers.	hsa_circ_0000826				colorectal cancer liver metastases 	MONDO:0021063	malignant colon neoplasm	up-regulated	RT-qPCR; RNA-seq	"circRNA_0000826 is significantly up-regulated in CRC with liver metastasis versus CRC without liver metastasis. It has diagnostic potential for identifying CRC-m, and its putative circRNA-miRNA-mRNA interaction network was predicted bioinformatically."	0.5047
30630697	EBioMedicine	2019	Three isoforms of exosomal circPTGR1 promote hepatocellular carcinoma metastasis via the miR449a-MET pathway.	hsa_circ_0008043	circPTGR1	hsa_circ_PTGR1	PTGR1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0008043 (circPTGR1 isoform) is enriched in HCC cell-derived exosomes and is upregulated in serum exosomes from HCC patients. It promotes HCC cell migration/invasion and metastasis by sponging miR449a to increase MET expression, and higher exosomal expression is associated with worse disease-free survival."	0.8162
30630697	EBioMedicine	2019	Three isoforms of exosomal circPTGR1 promote hepatocellular carcinoma metastasis via the miR449a-MET pathway.	hsa_circ_0003731	circPTGR1	hsa_circ_PTGR1	PTGR1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0003731 (circPTGR1 isoform) is upregulated in metastatic HCC cell/exosome contexts and in patient serum exosomes, and is linked to stage and poor prognosis. Functionally, circPTGR1 promotes HCC migration/invasion and metastasis through a miR449a-dependent increase of MET."	0.814
30630697	EBioMedicine	2019	Three isoforms of exosomal circPTGR1 promote hepatocellular carcinoma metastasis via the miR449a-MET pathway.	hsa_circ_0088030	circPTGR1	hsa_circ_PTGR1	PTGR1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0088030 (circPTGR1 isoform) is an exosomal circRNA upregulated in HCC patient serum exosomes and metastatic HCC cell contexts. It promotes HCC migration/invasion and metastasis via a ceRNA axis involving miR449a and MET, and higher expression is linked to poorer prognosis."	0.814
30655696	Cancer management and research	2019	A circular RNA hsa_circ_0079929 inhibits tumor growth in hepatocellular carcinoma.	hsa_circ_0079929	hsa_circ_0079299	hsa_circ_CDK13	CDK13	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"hsa_circ_0079929 (CDK13-derived) is down-regulated in HCC tissues and HCC cell lines. Its overexpression suppresses HCC tumor cell proliferation and tumorigenesis, and retards cell cycle progression, partly by inhibiting the PI3K/AKT/mTOR pathway and reducing nuclear CCNB1."	0.6643
30665425	Molecular cancer	2019	Circular RNA 100146 functions as an oncogene through direct binding to miR-361-3p and miR-615-5p in non-small cell lung cancer.	hsa_circ_0011385	circRNA 100146	hsa_circ_EIF3I	EIF3I	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circRNA 100146 is up-regulated in NSCLC tissues and cell lines and acts as an oncogene. Its knockdown suppresses proliferation, migration/invasion and tumor growth while promoting apoptosis, partly by sponging miR-361-3p and miR-615-5p to affect downstream targets and by interacting with SF3 family splicing factors (including SF3B3)."	0.8792
30670688	Cell death & disease	2019	Circular RNA hsa_circ_001783 regulates breast cancer progression via sponging miR-200c-3p.		hsa_circ_001783	hsa_circ_EBLN3	EBLN3	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; ISH	"hsa_circ_001783 is up-regulated in breast cancer (particularly TNBC) and mainly localized in the cytoplasm. It promotes proliferation and metastatic traits by sponging miR-200c-3p, thereby derepressing miR-200c-3p targets such as ZEB1/2 and ETS1. High hsa_circ_001783 expression correlates with heavier tumor burden and poorer disease-free survival, supporting its prognostic potential."	0.8547
30670716	Scientific reports	2019	Comprehensive circRNA expression profile during ischemic postconditioning attenuating hepatic ischemia/reperfusion injury.		mmu_circRNA_005186	mmu_circ_Epha2	Epha2	hepatic ischemia	MONDO:0100430	fibrotic liver disease	up-regulated	RT-qPCR; Microarray	"In mouse hepatic I/R injury, mmu_circRNA_005186 is up-regulated and participates in a ceRNA axis by sponging miR-124-3p to enhance Epha2 expression. Silencing mmu_circRNA_005186 in LPS-treated RAW264.7 macrophages reduces inflammatory cytokines, consistent with an inflammation-promoting role."	0.6777
30670716	Scientific reports	2019	Comprehensive circRNA expression profile during ischemic postconditioning attenuating hepatic ischemia/reperfusion injury.		mmu_circRNA_011137	mmu_circ_R3hcc1l	R3hcc1l	hepatic ischemia	MONDO:0100430	fibrotic liver disease	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_011137 is down-regulated in mouse hepatic I/R injury versus normal liver and was validated by qRT-PCR, but no specific downstream miRNA/mRNA mechanism was reported for this circRNA."	0.4625
30670716	Scientific reports	2019	Comprehensive circRNA expression profile during ischemic postconditioning attenuating hepatic ischemia/reperfusion injury.		mmu_circRNA_013703	mmu_circ_Nufip2	Nufip2	hepatic ischemia	MONDO:0100430	fibrotic liver disease	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_013703 is down-regulated in mouse hepatic I/R injury versus normal liver and was validated by qRT-PCR, but the paper did not report a specific functional mechanism for this circRNA."	0.4625
30670716	Scientific reports	2019	Comprehensive circRNA expression profile during ischemic postconditioning attenuating hepatic ischemia/reperfusion injury.		mmu_circRNA_29140	mmu_circ_Adcy9	Adcy9	hepatic ischemia	MONDO:0100430	fibrotic liver disease	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_29140 is down-regulated in mouse hepatic I/R injury and was validated by qRT-PCR, but its downstream interaction partners and mechanism were not detailed in the paper."	0.4625
30670716	Scientific reports	2019	Comprehensive circRNA expression profile during ischemic postconditioning attenuating hepatic ischemia/reperfusion injury.		mmu_circRNA_36837	mmu_circ_Akap2	Akap2	hepatic ischemia	MONDO:0100430	fibrotic liver disease	down-regulated	RT-qPCR; Microarray	mmu_circRNA_36837 is down-regulated in mouse hepatic I/R injury and was validated by qRT-PCR; the study did not further characterize its mechanism.	0.4625
30670716	Scientific reports	2019	Comprehensive circRNA expression profile during ischemic postconditioning attenuating hepatic ischemia/reperfusion injury.		mmu_circRNA_43819	mmu_circ_Raver1	Raver1	hepatic ischemia	MONDO:0100430	fibrotic liver disease	up-regulated	RT-qPCR; Microarray	"mmu_circRNA_43819 is up-regulated in mouse hepatic I/R injury and was qRT-PCR validated. The study constructed a putative ceRNA axis (mmu_circRNA_43819_miR-210-5p_Egr1) based on verified expression trends, without additional functional assays for this circRNA."	0.4997
30670781	Oncogene	2019	Circ-ZNF609 regulates G1-S progression in rhabdomyosarcoma.		circ-ZNF609	hsa_circ_ZNF609	ZNF609	rhabdomyosarcoma 	MONDO:0005212	rhabdomyosarcoma	up-regulated	RT-qPCR	"circ-ZNF609 is up-regulated in RMS (ERMS and ARMS) tumors and cell lines. In ERMS-derived RD cells, circ-ZNF609 knockdown induces a G1/S arrest and reduces p-Akt and pRb/Rb, with evidence that it counteracts proteasome-dependent degradation of p-Akt, supporting a role in promoting proliferation via PI3K/AKT-related cell-cycle control."	0.6221
30674324	Molecular cancer	2019	Circular RNA profiling and its potential for esophageal squamous cell cancer diagnosis and prognosis.	hsa_circ_0062459				esophageal squamous cell cancer 	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0062459 is down-regulated in pre-operative plasma from ESCC patients versus healthy controls and was evaluated as a plasma diagnostic biomarker, including ROC analysis and a combined signature with hsa_circ_0001946."	0.5047
30674324	Molecular cancer	2019	Circular RNA profiling and its potential for esophageal squamous cell cancer diagnosis and prognosis.	hsa_circ_0076535				esophageal squamous cell cancer 	MONDO:0005580	esophageal squamous cell carcinoma	unknown	RT-qPCR; Microarray	"hsa_circ_0076535 was identified by circRNA microarray in ESCC tissues and its differential expression was consistent with the microarray result by RT-qPCR validation in tissue pairs, but the up/down direction is not provided in the supplied text."	0.3588
30674324	Molecular cancer	2019	Circular RNA profiling and its potential for esophageal squamous cell cancer diagnosis and prognosis.	hsa_circ_0072215				esophageal squamous cell cancer 	MONDO:0005580	esophageal squamous cell carcinoma	unknown	RT-qPCR; Microarray	hsa_circ_0072215 was identified as differentially expressed in ESCC tissues (microarray and RT-qPCR consistency) but was not detectable in patient or healthy plasma/serum in this study; expression change direction is not provided in the supplied text.	0.3588
30674324	Molecular cancer	2019	Circular RNA profiling and its potential for esophageal squamous cell cancer diagnosis and prognosis.	hsa_circ_0042261				esophageal squamous cell cancer 	MONDO:0005580	esophageal squamous cell carcinoma	unknown	RT-qPCR; Microarray	hsa_circ_0042261 was among tissue-validated differentially expressed circRNAs in ESCC but was not detectable in patient or healthy plasma/serum in this study; expression change direction is not provided in the supplied text.	0.3588
30674324	Molecular cancer	2019	Circular RNA profiling and its potential for esophageal squamous cell cancer diagnosis and prognosis.	hsa_circ_0001946				esophageal squamous cell cancer 	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0001946 is down-regulated in ESCC patient plasma and serves as a diagnostic biomarker by ROC analysis. High hsa_circ_0001946 in tumor tissues predicts worse DFS/OS, and overexpression suppresses ESCC cell proliferation, migration, and invasion; it is cytoplasmic and is linked to a predicted miRNA (miRNA-7-5p)_mRNA network."	0.7206
30674872	Cell death & disease	2019	Preclinical study using circular RNA 17 and micro RNA 181c-5p to suppress the enzalutamide-resistant prostate cancer progression.	hsa_circ_0001427	circRNA17	hsa_circ_PDLIM5	PDLIM5	prostate cancer 	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR	"circRNA17 is down-regulated in enzalutamide-resistant CRPC and high-Gleason-score prostate cancer. It suppresses ARv7-driven enzalutamide resistance and invasion by interacting with and stabilizing miR-181c-5p, which directly targets the ARv7 3¡äUTR; enzalutamide represses circRNA17 via transcriptional suppression of its host gene PDLIM5."	0.8166
30675276	Oncology letters	2019	Circular RNA hsa_circ_0078602 may have potential as a prognostic biomarker for patients with hepatocellular carcinoma.	hsa_circ_0078602				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0078602 is down-regulated in hepatocellular carcinoma tissues versus adjacent non-cancerous tissues. Lower expression is associated with poorer overall survival and it shows diagnostic potential by ROC analysis. Mechanistically, the study reports bioinformatically predicted associations with several miRNAs, but no experimental mechanistic validation."	0.5734
30675276	Oncology letters	2019	Circular RNA hsa_circ_0078602 may have potential as a prognostic biomarker for patients with hepatocellular carcinoma.	hsa_circ_0018764				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0018764 is down-regulated in HCC tissues versus paired non-cancerous tissues and was validated by RT-qPCR consistent with microarray results. It was assessed by ROC analysis but was not selected for further investigation, and no mechanism or prognostic association was established."	0.4679
30680715	Journal of cellular physiology	2019	Circular RNA hsa_circ_0007059 indicates prognosis and influences malignant behavior via AKT/mTOR in oral squamous cell carcinoma.	hsa_circ_0007059		hsa_circ_ZNF720	ZNF720	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR; RNA-seq; Microarray	"hsa_circ_0007059 is down-regulated in OSCC tissues and cell lines. Its overexpression suppresses proliferation, migration and invasion while promoting apoptosis, and it inhibits xenograft tumor growth, at least partly by reducing p-AKT and downstream p-mTOR levels (AKT/mTOR pathway)."	0.6977
30692147	Genome research	2019	The circular RNome of primary breast cancer.		"circCNOT2 (Chr 12: 70,278,132_70,311,018)"	hsa_circ_CNOT2	CNOT2	primary breast cancer 	MONDO:0007254	breast cancer	unknown	RT-qPCR; RNA-seq	"circCNOT2 is present in primary breast tumors and detectable in plasma cfRNA. Functional knockdown of circCNOT2 reduces viability of MCF-7 and BT-474 breast cancer cells. In ER-positive advanced breast cancer treated with aromatase inhibitors, higher circCNOT2 levels predict shorter progression-free survival, while linear CNOT2 does not."	0.7286
30692147	Genome research	2019	The circular RNome of primary breast cancer.		"circCREBBP (Chr 16: 3,850,297_3,851,009)"	hsa_circ_CREBBP	CREBBP	primary breast cancer 	MONDO:0007254	breast cancer	unknown	RT-qPCR; RNA-seq	"circCREBBP (genomic region chr16:3850297-3851009) was detected by RNA-seq and confirmed in an independent pool of primary breast tumors using PCR-based assays and RT-qPCR. The study notes it as a candidate with poor correlation to linear CREBBP, suggesting possible specific regulation, but provides no specific downstream mechanism or clinical association for circCREBBP in the provided text."	0.4773
30692147	Genome research	2019	The circular RNome of primary breast cancer.		"circRERE(Chr 1: 8,541,214_8,614,686)"	hsa_circ_RERE	RERE	primary breast cancer 	MONDO:0007254	breast cancer	unknown	RT-qPCR; RNA-seq	"circRERE was detected in primary breast cancer RNA-seq data and its presence was confirmed by RT-PCR in an independent pool of 100 breast tumors. It is mentioned among circRNAs differentially expressed in association with proliferative tumor characteristics, but the study does not provide a specific mechanism or clinical outcome analysis for circRERE in the provided text."	0.429
30692912	Frontiers in molecular neuroscience	2018	Circular RNA Expression Alteration and Bioinformatics Analysis in Rats After Traumatic Spinal Cord Injury.		rno_circRNA_005342			traumatic spinal cord injury 	MONDO:0043797	spinal cord injury	down-regulated	RT-qPCR; Microarray	"rno_circRNA_005342 is significantly downregulated in rat spinal cord tissue 3 days after traumatic SCI versus sham, validated by RT-qPCR. It was included in a bioinformatically predicted circRNA/miRNA/mRNA (ceRNA) interaction network and downstream GO/KEGG enrichment (e.g., AMPK and peroxisome-related pathways), but functional/mechanistic interactions were not experimentally validated."	0.5922
30692912	Frontiers in molecular neuroscience	2018	Circular RNA Expression Alteration and Bioinformatics Analysis in Rats After Traumatic Spinal Cord Injury.		rno_circRNA_015513			traumatic spinal cord injury 	MONDO:0043797	spinal cord injury	down-regulated	RT-qPCR; Microarray	"rno_circRNA_015513 is significantly downregulated in rat spinal cord tissue 3 days after traumatic SCI versus sham, validated by RT-qPCR. It was used to build a predicted circRNA/miRNA/mRNA interaction network and related enrichment analyses, but the predicted interactions and functions were not experimentally validated."	0.5922
30692912	Frontiers in molecular neuroscience	2018	Circular RNA Expression Alteration and Bioinformatics Analysis in Rats After Traumatic Spinal Cord Injury.		rno_circRNA_002948			traumatic spinal cord injury 	MONDO:0043797	spinal cord injury	down-regulated	RT-qPCR; Microarray	"rno_circRNA_002948 is significantly downregulated in rat spinal cord tissue after traumatic SCI versus sham, supported by both microarray and RT-qPCR. It was carried forward into predicted ceRNA network and enrichment analyses (AMPK and peroxisome-related pathways among top hits), but no direct functional assays were performed for this circRNA."	0.5922
30692912	Frontiers in molecular neuroscience	2018	Circular RNA Expression Alteration and Bioinformatics Analysis in Rats After Traumatic Spinal Cord Injury.		rno_circRNA_006096			traumatic spinal cord injury 	MONDO:0043797	spinal cord injury	down-regulated	RT-qPCR; Microarray	"rno_circRNA_006096 is significantly downregulated in rat spinal cord tissue after traumatic SCI versus sham, with consistent microarray and RT-qPCR results. It was included in a predicted ceRNA interaction network and pathway enrichment analyses, but no direct interaction/function experiments were conducted."	0.5922
30692912	Frontiers in molecular neuroscience	2018	Circular RNA Expression Alteration and Bioinformatics Analysis in Rats After Traumatic Spinal Cord Injury.		rno_circRNA_013017			traumatic spinal cord injury 	MONDO:0043797	spinal cord injury	down-regulated	RT-qPCR; Microarray	"rno_circRNA_013017 is significantly downregulated in rat spinal cord tissue after traumatic SCI versus sham, confirmed by RT-qPCR. It was included in a predicted circRNA/miRNA/mRNA network and associated metabolic pathway enrichments, but no experimental validation of specific miRNA/mRNA interactions or functional phenotypes was performed."	0.5922
30693177	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2019	Circular RNA circNOL10 Inhibits Lung Cancer Development by Promoting SCLM1-Mediated Transcriptional Regulation of the Humanin Polypeptide Family.	hsa_circ_0000977	hsa_circ_001918	hsa_circ_NOL10		lung cancer 	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	"circNOL10 is down-regulated in lung cancer and functions as a tumor suppressor. It directly interacts with SCML1 to inhibit SCML1 ubiquitination, increases SCML1 expression, and enhances SCML1-mediated transcription of the humanin polypeptide family (e.g., HN2/HN8), leading to altered mitochondrial function and reduced proliferation/cell-cycle progression with increased apoptosis."	0.8096
30697481	PeerJ	2019	Genome-wide analysis of circular RNAs in goat skin fibroblast cells in response to Orf virus infection.		circRNA1001			Orf virus infection	MONDO:0025003	goat disease	down-regulated	RT-qPCR; RNA-seq	circRNA1001 is down-regulated in ORFV-infected goat skin fibroblast cells compared with uninfected controls and was experimentally validated by qRT-PCR and Sanger sequencing.	0.437
30697481	PeerJ	2019	Genome-wide analysis of circular RNAs in goat skin fibroblast cells in response to Orf virus infection.		circRNA1684			Orf virus infection	MONDO:0025003	goat disease	down-regulated	RT-qPCR; RNA-seq	"circRNA1684 is down-regulated after ORFV infection in goat skin fibroblast cells. It is proposed to act as a ceRNA by sponging chi-miR-92a-5p, thereby indirectly down-regulating a set of downstream genes."	0.4761
30697481	PeerJ	2019	Genome-wide analysis of circular RNAs in goat skin fibroblast cells in response to Orf virus infection.		circRNA3127			Orf virus infection	MONDO:0025003	goat disease	down-regulated	RT-qPCR; RNA-seq	circRNA3127 is down-regulated after ORFV infection in goat skin fibroblast cells. It is proposed to bind chi-miR-103-5P and thereby indirectly down-regulate downstream genes in a ceRNA-like network.	0.4761
30697481	PeerJ	2019	Genome-wide analysis of circular RNAs in goat skin fibroblast cells in response to Orf virus infection.		circRNA7880			Orf virus infection	MONDO:0025003	goat disease	up-regulated	RT-qPCR; RNA-seq	circRNA7880 is up-regulated in ORFV-infected goat skin fibroblast cells compared with uninfected controls and was experimentally validated by qRT-PCR and Sanger sequencing.	0.437
30700934	Chinese journal of cancer research = Chung-kuo yen cheng yen chiu	2018	Novel circular RNA expression profile of uveal melanoma revealed by microarray.	hsa_circ_0119873		hsa_circ_RASGRP3	RasGRP3	uveal melanoma 	MONDO:0006486	uveal melanoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0119873 is up-regulated in uveal melanoma tissues versus normal uvea and was validated by qRT-PCR. The study predicts that it may act through circRNA_miRNA interactions (e.g., miR-92a-3p/miR-193a-5p/miR-204-3p) and is linked to the host gene RasGRP3."	0.4032
30700934	Chinese journal of cancer research = Chung-kuo yen cheng yen chiu	2018	Novel circular RNA expression profile of uveal melanoma revealed by microarray.	hsa_circ_0128533		hsa_circ_MYO10	MYO10	uveal melanoma 	MONDO:0006486	uveal melanoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0128533 is up-regulated in uveal melanoma and validated by qRT-PCR. Bioinformatic prediction suggests it may sponge miR-145 (and other miRNAs), potentially impacting apoptosis, but this functional role is not experimentally validated in this paper."	0.4032
30700934	Chinese journal of cancer research = Chung-kuo yen cheng yen chiu	2018	Novel circular RNA expression profile of uveal melanoma revealed by microarray.	hsa_circ_0047924		hsa_circ_RTTN	RTTN	uveal melanoma 	MONDO:0006486	uveal melanoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0047924 (host gene RTTN) is up-regulated in uveal melanoma and validated by qRT-PCR. The paper predicts its potential miRNA-binding partners (e.g., miR-204-3p/miR-22-5p/miR-338-3p) via bioinformatics without functional wet-lab assays."	0.4032
30700934	Chinese journal of cancer research = Chung-kuo yen cheng yen chiu	2018	Novel circular RNA expression profile of uveal melanoma revealed by microarray.	hsa_circ_0103232		hsa_circ_OCA2	OCA2	uveal melanoma 	MONDO:0006486	uveal melanoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0103232 (host gene OCA2) is up-regulated in uveal melanoma and validated by qRT-PCR. The paper provides bioinformatic prediction of its candidate miRNA binding partners, but no downstream functional experiments are reported."	0.4032
30700934	Chinese journal of cancer research = Chung-kuo yen cheng yen chiu	2018	Novel circular RNA expression profile of uveal melanoma revealed by microarray.		hsa-circRNA10628-6	hsa_circ_OCA2	OCA2	uveal melanoma 	MONDO:0006486	uveal melanoma	up-regulated	RT-qPCR; Microarray	hsa-circRNA10628-6 (host gene OCA2) is up-regulated in uveal melanoma and validated by qRT-PCR. The study reports bioinformatic prediction of candidate miRNA targets (including miR-197-5p and miR-214-3p) but provides no mechanistic wet-lab validation.	0.4032
30700934	Chinese journal of cancer research = Chung-kuo yen cheng yen chiu	2018	Novel circular RNA expression profile of uveal melanoma revealed by microarray.	hsa_circ_0032148		hsa_circ_KCNH5	KCNH5	uveal melanoma 	MONDO:0006486	uveal melanoma	down-regulated	RT-qPCR; Microarray	hsa_circ_0032148 (host gene KCNH5) is down-regulated in uveal melanoma and validated by qRT-PCR. The study provides predicted miRNA interaction partners via bioinformatics but no experimental functional characterization.	0.4032
30700934	Chinese journal of cancer research = Chung-kuo yen cheng yen chiu	2018	Novel circular RNA expression profile of uveal melanoma revealed by microarray.	hsa_circ_0133460		hsa_circ_DGKI	DGKI	uveal melanoma 	MONDO:0006486	uveal melanoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0133460 (host gene DGKI) is down-regulated in uveal melanoma and validated by qRT-PCR. The paper predicts its miRNA binding partners and notes DGKI is linked to RasGRP3/Ras signaling based on prior evidence, but it does not experimentally test this axis in UM."	0.4032
30714679	Cancer medicine	2019	Circular RNA expression profiles of peripheral blood mononuclear cells in hepatocellular carcinoma patients by sequence analysis.	hsa_circ_0005505		hsa_circ_IRAK3	IRAK3	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005505 is up-regulated in PBMCs of HCC patients versus healthy controls, identified by RNA-seq and confirmed by RT-qPCR in a larger clinical cohort."	0.3588
30714679	Cancer medicine	2019	Circular RNA expression profiles of peripheral blood mononuclear cells in hepatocellular carcinoma patients by sequence analysis.	hsa_circ_0001394		hsa_circ_TBC1D14	TBC1D14	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0001394 is up-regulated in PBMCs of HCC patients and its differential expression was confirmed by RT-qPCR following RNA-seq screening.	0.3588
30714679	Cancer medicine	2019	Circular RNA expression profiles of peripheral blood mononuclear cells in hepatocellular carcinoma patients by sequence analysis.	hsa_circ_0000798		hsa_circ_BPTF	BPTF	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ_0000798 (hsa_circ_0000798; host gene BPTF) is up-regulated in PBMCs from HCC patients and is associated with worse overall survival and diagnostic potential (ROC AUC 0.703). Mechanistically, it is predicted to act as a miRNA sponge in a circRNA-miRNA-mRNA network affecting immune-related genes."	0.6895
30714679	Cancer medicine	2019	Circular RNA expression profiles of peripheral blood mononuclear cells in hepatocellular carcinoma patients by sequence analysis.	hsa_circ_0004771		hsa_circ_NRIP1	NRIP1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0004771 is down-regulated in PBMCs of HCC patients and its differential expression was confirmed by RT-qPCR following RNA-seq screening.	0.3588
30714679	Cancer medicine	2019	Circular RNA expression profiles of peripheral blood mononuclear cells in hepatocellular carcinoma patients by sequence analysis.	hsa_circ_0001074		hsa_circ_ORC4	ORC4	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0001074 is down-regulated in PBMCs of HCC patients and its differential expression was confirmed by RT-qPCR following RNA-seq screening.	0.3588
30714679	Cancer medicine	2019	Circular RNA expression profiles of peripheral blood mononuclear cells in hepatocellular carcinoma patients by sequence analysis.	hsa_circ_0067735		hsa_circ_MED12L	MED12L	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0067735 is down-regulated in PBMCs of HCC patients and its differential expression was confirmed by RT-qPCR following RNA-seq screening.	0.3588
30717751	Molecular cancer	2019	Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway.	hsa_circ_0004771		hsa_circ_NRIP1	NRIP	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"circNRIP1 is upregulated in gastric cancer and promotes malignant phenotypes by sponging miR-149-5p, thereby increasing AKT1 and activating the AKT/mTOR axis to enhance glycolysis/Warburg effect, EMT, and metastasis while suppressing autophagy. circNRIP1 can be transferred via exosomes and its biogenesis is promoted by the RBP QKI; high circNRIP1 associates with worse survival."	0.8921
30719998	Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association	2019	Circular RNA ARHGAP26 is over-expressed and its downregulation inhibits cell proliferation and promotes cell apoptosis in gastric cancer cells.	hsa_circ_0074362		hsa_circ_ARHGAP26	ARHGAP26	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ-ARHGAP26 is up-regulated in multiple gastric cancer cell lines versus normal gastric epithelial cells. Knockdown of circ-ARHGAP26 suppresses proliferation and increases apoptosis (with increased C-Caspase3 and decreased Bcl-2), suggesting an oncogenic role; miRNA targets were predicted but not experimentally validated."	0.414
30720076	Molecular medicine reports	2019	circRNA_miRNA association for coronary heart disease.	hsa_circ_0030769				coronary heart disease 	MONDO:0005010	coronary artery disorder	unknown	Microarray	This circRNA was included among the circRNAs analyzed by microarray in peripheral blood of CHD patients and was shown in a predicted circRNA_miRNA coexpression/network association with hsa-miR-101-5p.	0.1768
30720076	Molecular medicine reports	2019	circRNA_miRNA association for coronary heart disease.	hsa_circ_0079828				coronary heart disease 	MONDO:0005010	coronary artery disorder	unknown	Microarray	This circRNA was part of the CHD peripheral blood circRNA microarray profile and was included in a predicted circRNA_miRNA association network linking it to hsa-miR-101-5p.	0.1768
30720076	Molecular medicine reports	2019	circRNA_miRNA association for coronary heart disease.	hsa_circ_0122274		hsa_circ_ATR	ATR	coronary heart disease 	MONDO:0005010	coronary artery disorder	unknown	Microarray	hsa_circ_0122274 (host gene ATR) was identified from peripheral blood circRNA microarray profiling in CHD and appeared in the predicted circRNA_miRNA association network with hsa-miR-101-5p.	0.1768
30720076	Molecular medicine reports	2019	circRNA_miRNA association for coronary heart disease.		hsa_circ_15486-161	hsa_circ_PRKDC	PRKDC	coronary heart disease 	MONDO:0005010	coronary artery disorder	unknown	Microarray	hsa_circ_15486-161 (host gene PRKDC) was identified from peripheral blood microarray profiling in CHD and was included in a predicted circRNA_miRNA association with hsa-miR-101-5p.	0.1768
30720076	Molecular medicine reports	2019	circRNA_miRNA association for coronary heart disease.		hsa_circ_16316-13	hsa_circ_UTY	UTY	coronary heart disease 	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR; Microarray	hsa_circ_16316-13 (UTY-derived) was up-regulated in peripheral blood from CHD patients and its increased level was confirmed by qPCR consistent with the microarray results.	0.4032
30720076	Molecular medicine reports	2019	circRNA_miRNA association for coronary heart disease.	hsa_circ_0140538				coronary heart disease 	MONDO:0005010	coronary artery disorder	down-regulated	Microarray	"hsa_circ_0140538 was down-regulated in CHD peripheral blood by microarray and was proposed (based on coexpression/prediction) to act on miRNAs including hsa-miR-101-5p, hsa-miR-148a-3p and hsa-miR-1260a in the CHD-related circRNA_miRNA network."	0.1768
30720095	Molecular medicine reports	2019	Comprehensive circular RNA expression profiles in a mouse model of nonalcoholic steatohepatitis.		mmu_circRNA-29981			nonalcoholic steatohepatitis 	MONDO:0007027	metabolic dysfunction-associated steatohepatitis	up-regulated	RT-qPCR; Microarray	"In an MCD diet-induced NASH mouse model, circRNA_29981 is significantly up-regulated and was the only RT-qPCR-validated circRNA highlighted for further study. Bioinformatics prediction suggests it may act through circRNA_miRNA interactions to regulate hepatic stellate cell activation in NASH."	0.5495
30720095	Molecular medicine reports	2019	Comprehensive circular RNA expression profiles in a mouse model of nonalcoholic steatohepatitis.		mmu_circRNA_28028			nonalcoholic steatohepatitis 	MONDO:0007027	metabolic dysfunction-associated steatohepatitis	up-regulated	RT-qPCR; Microarray	mmu_circRNA_28028 is up-regulated in NASH mouse liver and its upregulation was consistent between microarray and RT-qPCR. Its downstream function was not experimentally investigated; only miRNA targets were bioinformatically predicted.	0.5495
30720095	Molecular medicine reports	2019	Comprehensive circular RNA expression profiles in a mouse model of nonalcoholic steatohepatitis.		mmu_circRNA_004372			nonalcoholic steatohepatitis 	MONDO:0007027	metabolic dysfunction-associated steatohepatitis	up-regulated	RT-qPCR; Microarray	mmu_circRNA_004372 is up-regulated in NASH mouse liver and was among the circRNAs whose microarray trend was consistent with RT-qPCR. The study only provided predicted miRNA binding targets without functional validation.	0.5495
30720095	Molecular medicine reports	2019	Comprehensive circular RNA expression profiles in a mouse model of nonalcoholic steatohepatitis.	mmu_circ_0043021	mmu_circRNA_43021			nonalcoholic steatohepatitis 	MONDO:0007027	metabolic dysfunction-associated steatohepatitis	up-regulated	RT-qPCR; Microarray	This circRNA (reported as circRNA-0043021 / mmu_circRNA_43021) was up-regulated in NASH mouse liver with microarray results broadly consistent with RT-qPCR. No specific mechanism or functional experiments were reported for it.	0.516
30720095	Molecular medicine reports	2019	Comprehensive circular RNA expression profiles in a mouse model of nonalcoholic steatohepatitis.		mmu_circRNA_36096 / circRNA-36096			nonalcoholic steatohepatitis 	MONDO:0007027	metabolic dysfunction-associated steatohepatitis	up-regulated	RT-qPCR; Microarray	mmu_circRNA_36096 is up-regulated in NASH mouse liver and its microarray trend was broadly consistent with RT-qPCR. The paper did not report specific downstream mechanisms or functional roles for this circRNA.	0.516
30728056	Journal of experimental & clinical cancer research : CR	2019	CircRNA circ_0000190 inhibits the progression of multiple myeloma through modulating miR-767-5p/MAPK4 pathway.	hsa_circ_0000190				multiple myeloma 	MONDO:0009693	plasma cell myeloma	down-regulated	RT-qPCR	circ_0000190 is down-regulated in multiple myeloma and mainly localizes to the cytoplasm. It suppresses MM cell proliferation/viability and G1-S cell-cycle progression and inhibits xenograft tumor growth by sponging miR-767-5p to de-repress MAPK4.	0.7859
30733646	Cancer cell international	2019	hsa_circ_0081143 promotes cisplatin resistance in gastric cancer by targeting miR-646/CDK6 pathway.	hsa_circ_0081143				gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0081143 is up-regulated in gastric cancer and correlates with advanced clinical features and poor overall survival. Functionally, it promotes proliferation/invasion and cisplatin resistance. Mechanistically, it sponges miR-646 to relieve repression of CDK6, thereby supporting GC progression."	0.8353
30735636	Cell	2019	The Landscape of Circular RNA in Cancer.			hsa_circ_AURKA	AURKA	neuroendocrine prostate cancer 	MONDO:0002477	prostate neuroendocrine neoplasm	up-regulated	RT-qPCR; RNA-seq	"circ-AURKA is significantly up-regulated in neuroendocrine prostate cancer compared with CRPC. Its circular structure and backsplice (exon 6 to exon 3) were confirmed by RT-qPCR after RNase R treatment, and it shows higher expression in the NEPC cell line NCI-H660 than in non-NEPC prostate cancer cell lines."	0.4773
30735636	Cell	2019	The Landscape of Circular RNA in Cancer.			hsa_circ_AMACR	AMACR	neuroendocrine prostate cancer 	MONDO:0002477	prostate neuroendocrine neoplasm	down-regulated	RNA-seq	circ-AMACR is significantly down-regulated in neuroendocrine prostate cancer compared with CRPC based on differential circRNA expression analysis in the MiOncoCirc cohort.	0.1155
30735636	Cell	2019	The Landscape of Circular RNA in Cancer.			hsa_circ_AR	AR	metastatic castration-resistant prostate cancer 	MONDO:0850353	castration-resistant prostate carcinoma	up-regulated	RNA-seq	"circ-AR is detected in a substantial fraction of mCRPC cases with AR amplification but not in primary hormone-naive prostate cancer at the reported sequencing depth, suggesting association with AR focal amplification and potential use as an amplification indicator."	0.348
30735636	Cell	2019	The Landscape of Circular RNA in Cancer.		hsa_circ_USP9Y-TTTY15			prostate cancer	MONDO:0008315	prostate cancer	unknown	RT-qPCR	"A read-through circRNA spanning adjacent genes TTTY15 and USP9Y was experimentally validated in LNCaP cells. Divergent-primer RT-qPCR, RNase R resistance, and Sanger sequencing confirmed the backspliced junction and circular nature of this rt-circRNA detected in prostate cancer tissue samples."	0.4358
30736462	Cancers	2019	CircSMARCA5 Regulates VEGFA mRNA Splicing and Angiogenesis in Glioblastoma Multiforme Through the Binding of SRSF1.			hsa_circ_SMARCA5	SMARCA5	glioblastoma multiforme 	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR	"circSMARCA5 is down-regulated in GBM and physically binds the splicing factor SRSF1. By tethering SRSF1, circSMARCA5 modulates VEGFA alternative splicing, reducing the pro-angiogenic/anti-angiogenic VEGFA isoform ratio and associating with lower microvessel density. Higher circSMARCA5 expression indicates better OS/PFS, supporting its prognostic value and potential anti-angiogenic therapeutic relevance in GBM."	0.6986
30736838	Journal of experimental & clinical cancer research : CR	2019	FUS/circ_002136/miR-138-5p/SOX13 feedback loop regulates angiogenesis in Glioma.	hsa_circ_0000005	circ_002136	hsa_circ_CDK11A	CDK11A	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ_002136 is up-regulated in glioma-exposed endothelial cells and promotes angiogenesis-related phenotypes (viability, migration, tube formation). Mechanistically, it is promoted by FUS binding and acts as a ceRNA by sponging miR-138-5p to increase SOX13, which transcriptionally activates SPON2 and also enhances FUS to form a positive feedback loop."	0.721
30736847	Clinical epigenetics	2019	Hsa_circRNA_0054633 is highly expressed in gestational diabetes mellitus and closely related to glycosylation index.	hsa_circ_0054633				gestational diabetes mellitus 	MONDO:0005406	gestational diabetes	up-regulated	RT-qPCR	"hsa_circRNA_0054633 is up-regulated in GDM maternal serum (second/third trimester) and placenta, but lower in GDM cord blood. It correlates with glycated hemoglobin markers (GHBA1/GHBA1c) and shows diagnostic potential for GDM based on ROC/AUC analyses; mechanistic details were not experimentally defined."	0.459
30736847	Clinical epigenetics	2019	Hsa_circRNA_0054633 is highly expressed in gestational diabetes mellitus and closely related to glycosylation index.		hsa_circRNA_063981			gestational diabetes mellitus 	MONDO:0005406	gestational diabetes	dysregulated	RT-qPCR	"hsa_circRNA_063981 shows stage/tissue-dependent dysregulation in GDM: it is lower in third-trimester maternal serum but higher in cord blood (relative to controls), and it has modest diagnostic value by ROC analysis. The study reports correlation with hsa_circRNA_103410 in placenta but does not define a molecular mechanism."	0.459
30736847	Clinical epigenetics	2019	Hsa_circRNA_0054633 is highly expressed in gestational diabetes mellitus and closely related to glycosylation index.		hsa_circRNA_102682			gestational diabetes mellitus 	MONDO:0005406	gestational diabetes	down-regulated	RT-qPCR	hsa_circRNA_102682 is down-regulated in GDM in the third-trimester maternal serum (lower than controls) and provides diagnostic value by ROC analysis; no mechanism was experimentally established.	0.459
30736847	Clinical epigenetics	2019	Hsa_circRNA_0054633 is highly expressed in gestational diabetes mellitus and closely related to glycosylation index.		hsa_circRNA_103410			gestational diabetes mellitus 	MONDO:0005406	gestational diabetes	up-regulated	RT-qPCR	"hsa_circRNA_103410 is up-regulated in GDM placental tissue and correlates with hsa_circRNA_0054633 in maternal third-trimester serum and neonatal cord blood; it also correlates with hsa_circRNA_063981 in placenta. It shows diagnostic value in cord blood by ROC analysis, but no mechanism is experimentally defined."	0.459
30744636	Molecular cancer	2019	circKIF4A acts as a prognostic factor and mediator to regulate the progression of triple-negative breast cancer.	hsa_circ_0007255	circKIF4A	hsa_circ_KIF4A	KIF4A	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; Microarray	"circKIF4A (hsa_circ_0007255) is up-regulated in TNBC tissues and cell lines and its high expression is associated with worse patient survival. Functionally, circKIF4A promotes TNBC proliferation, migration/EMT and metastasis, and mechanistically acts as a ceRNA that sponges miR-375 to upregulate KIF4A."	0.8071
30745833	International journal of biological sciences	2019	Hypoxia-elevated circELP3 contributes to bladder cancer progression and cisplatin resistance.		circELP3	hsa_circ_ELP3	ELP3	bladder cancer	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; RNA-seq	"circELP3 is upregulated in bladder cancer tissues and is induced by hypoxia in bladder cancer cell lines. Functionally, circELP3 promotes proliferation, reduces apoptosis, enhances cisplatin resistance, and supports stem-like properties; circELP3 knockdown suppresses tumor growth in a nude mouse xenograft model. It localizes mainly to the cytoplasm and is suggested to act via a ceRNA/miRNA-sponge mechanism (predicted)."	0.6956
30764896	Oncology research	2019	Hsa_circ_0003998 Promotes Chemoresistance via Modulation of miR-326 in Lung Adenocarcinoma Cells.	hsa_circ_0003998				lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"hsa_circ_0003998 is up-regulated in LAD tissues and docetaxel-resistant LAD cell lines and promotes docetaxel chemoresistance. It directly binds (sponges) miR-326, and miR-326 mediates the effect of hsa_circ_0003998 on chemosensitivity, implicating a hsa_circ_0003998/miR-326/SP1 axis."	0.6479
30767300	Journal of cellular biochemistry	2019	Investigation of circular RNAs and related genes in pulmonary fibrosis based on bioinformatics analysis.		chr9:113534327|113546234	rno_circ_Ppp4r1	Ppp4r1	pulmonary fibrosis	MONDO:0002771	pulmonary fibrosis	down-regulated	RT-qPCR; RNA-seq	This circRNA is down-regulated in bleomycin-induced pulmonary fibrosis rat lung tissue. It is proposed to act as a miRNA sponge (rno-miR-30b-5p) affecting Cdkn2b and linking to Notch1-activated TGF-beta signaling in pulmonary fibrogenesis.	0.7062
30767300	Journal of cellular biochemistry	2019	Investigation of circular RNAs and related genes in pulmonary fibrosis based on bioinformatics analysis.		chr1:200648164|200672411	rno_circ_Fgfr2	Fgfr2	pulmonary fibrosis	MONDO:0002771	pulmonary fibrosis	down-regulated	RT-qPCR; RNA-seq	"This circRNA is down-regulated in bleomycin-induced pulmonary fibrosis rat lung tissue and was among the five circRNAs whose RT-qPCR trend matched sequencing predictions. Its predicted miRNA/mRNA targets were tested but did not validate consistently, so its downstream mechanism remains unclear in this study."	0.7062
30767300	Journal of cellular biochemistry	2019	Investigation of circular RNAs and related genes in pulmonary fibrosis based on bioinformatics analysis.		chr5:150850432|150865550	rno_circ_Eya3	Eya3	pulmonary fibrosis	MONDO:0002771	pulmonary fibrosis	up-regulated	RT-qPCR; RNA-seq	"This circRNA is up-regulated in bleomycin-induced pulmonary fibrosis rat lung tissue and was among the five circRNAs whose RT-qPCR trend matched sequencing predictions. However, its predicted miRNA/mRNA targets did not validate consistently, so the study does not establish a specific downstream axis for it."	0.7062
30767300	Journal of cellular biochemistry	2019	Investigation of circular RNAs and related genes in pulmonary fibrosis based on bioinformatics analysis.		chr20:14319170|14326640	rno_circ_Specc1l	Specc1l	pulmonary fibrosis	MONDO:0002771	pulmonary fibrosis	down-regulated	RT-qPCR; RNA-seq	"This circRNA is down-regulated in bleomycin-induced pulmonary fibrosis rat lung tissue. The study links it to a putative ceRNA network involving rno-miR-7b and the target mRNA Samd3, and suggests involvement in Notch1-activated TGF-beta signaling during pulmonary fibrogenesis."	0.7062
30767300	Journal of cellular biochemistry	2019	Investigation of circular RNAs and related genes in pulmonary fibrosis based on bioinformatics analysis.		chr10:57634023|57634588	rno_circ_Dhx33	Dhx33	pulmonary fibrosis	MONDO:0002771	pulmonary fibrosis	down-regulated	RT-qPCR; RNA-seq	"This circRNA is down-regulated in bleomycin-induced pulmonary fibrosis rat lung tissue. The study supports a ceRNA model where decreased chr10:57634023|57634588 associates with increased rno-miR-429 and decreased Tgfbr1, implicating Notch1-activated TGF-beta signaling in pulmonary fibrogenesis."	0.7062
30774431	Cancer management and research	2019	Circular RNA hsa_circ_0072309 inhibits proliferation and invasion of breast cancer cells via targeting miR-492.	hsa_circ_0072309				breast cancer	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	"hsa_circ_0072309 is down-regulated in breast cancer tissues/cells and functions as a tumor suppressor. It mainly localizes to the cytoplasm and sponges miR-492, thereby inhibiting breast cancer cell proliferation, migration, invasion, and xenograft tumor growth; miR-492 overexpression rescues these effects."	0.7369
30777071	Journal of translational medicine	2019	A two-circular RNA signature as a noninvasive diagnostic biomarker for lung adenocarcinoma.	hsa_circ_0005962		hsa_circ_YWHAZ	YWHAZ	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0005962 is up-regulated in LUAD plasma and LUAD cell lines and promotes LUAD cell proliferation in vitro. Mechanistically, the study predicts a ceRNA network in which hsa_circ_0005962 sponges multiple miRNAs (including hsa-miR-1265) and may increase YWHAZ expression, with enrichment implicating cancer-related pathways such as p53 signaling, PI3K-Akt signaling and cell cycle."	0.6368
30777071	Journal of translational medicine	2019	A two-circular RNA signature as a noninvasive diagnostic biomarker for lung adenocarcinoma.	hsa_circ_0086414				lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0086414 is down-regulated in LUAD plasma and LUAD cell lines and, together with hsa_circ_0005962, forms a plasma circRNA diagnostic signature for LUAD. Higher plasma hsa_circ_0086414 levels are associated with EGFR mutation status, and the study hypothesizes a miRNA-binding mechanism based on bioinformatic prediction."	0.5047
30777076	Molecular cancer	2019	CircPSMC3 suppresses the proliferation and metastasis of gastric cancer by acting as a competitive endogenous RNA through sponging miR-296-5p.			hsa_circ_PSMC3	PSMC3	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"circPSMC3 is down-regulated in gastric cancer tissues, plasma, and cell lines and functions as a tumor suppressor. It sponges miR-296-5p to relieve repression of PTEN, thereby inhibiting proliferation, migration/invasion, and metastasis, and shows diagnostic/prognostic potential as a circulating biomarker."	0.8498
30779728	Medical science monitor : international medical journal of experimental and clinical research	2019	CircRNA circ_0067934 Overexpression Correlates with Poor Prognosis and Promotes Thyroid Carcinoma Progression.	hsa_circ_0067934				thyroid carcinoma 	MONDO:0015075	thyroid gland carcinoma	up-regulated	RT-qPCR	"circ_0067934 is up-regulated in thyroid carcinoma tissues/cell lines and its high expression is associated with worse survival. Functionally, circ_0067934 promotes proliferation, migration, invasion and EMT while suppressing apoptosis, at least partly via activating PI3K/AKT signaling."	0.682
30782157	Molecular cancer	2019	Circular RNA cTFRC acts as the sponge of MicroRNA-107 to promote bladder carcinoma progression.	hsa_circ_0001445		hsa_circ_TFRC	TFRC	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"cTFRC is up-regulated in bladder cancer and is associated with higher grade, metastasis-related features, and poorer overall survival. Functionally, cTFRC promotes proliferation, invasion, EMT, and xenograft tumor growth by acting as a ceRNA that sponges miR-107, thereby de-repressing TFRC."	0.8071
30783441	Experimental and therapeutic medicine	2019	Circular RNA hsa_circ_0014243 may serve as a diagnostic biomarker for essential hypertension.	hsa_circ_0014243		hsa_circ_CARM1	CARM1	essential hypertension 	MONDO:0001134	essential hypertension	up-regulated	RT-qPCR	"hsa_circ_0014243 is up-regulated in whole blood from essential hypertension patients and is identified as a risk factor with moderate diagnostic performance by ROC analysis. The study proposes (via bioinformatics prediction) that it may sponge hsa-miR-10a-5p, though direct binding was not experimentally validated."	0.559
30785065	Molecular therapy. Nucleic acids	2019	circRAPGEF5 Contributes to Papillary Thyroid Proliferation and Metastatis by Regulation miR-198/FGFR1.	hsa_circ_0001681		hsa_circ_RAPGEF5	RAPGEF5	papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circRAPGEF5 is up-regulated in papillary thyroid cancer and promotes proliferation, migration/invasion and xenograft tumor growth. Mechanistically, it acts as a miRNA sponge for miR-198, thereby increasing FGFR1 expression via a circRAPGEF5/miR-198/FGFR1 ceRNA axis."	0.6829
30787278	Cell death & disease	2019	circTADA2As suppress breast cancer progression and metastasis via targeting miR-203a-3p/SOCS3 axis.	hsa_circ_0006220		hsa_circ_TADA2A	TADA2A	breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	"circTADA2A-E6 (hsa_circ_0006220) is down-regulated in breast cancer (including TNBC) and acts as a tumor suppressor. It primarily localizes to the cytoplasm and sponges miR-203a-3p (and also binds miR-302c-3p), relieving repression of SOCS3 to inhibit clonogenicity, proliferation, migration/invasion and xenograft tumor growth. Clinically, low circTADA2A-E6 associates with lymph node metastasis/advanced stage and poorer TNBC survival, with diagnostic potential by ROC analysis."	0.8426
30787278	Cell death & disease	2019	circTADA2As suppress breast cancer progression and metastasis via targeting miR-203a-3p/SOCS3 axis.	hsa_circ_0043278		hsa_circ_TADA2A	TADA2A	breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	"circTADA2A-E5/E6 (hsa_circ_0043278) is down-regulated in breast cancer/TNBC and was validated by RT-qPCR in clinical specimens and cell lines. It shows high diagnostic performance in TNBC by ROC analysis, but its association with survival and clinicopathologic parameters was not significant in this study, and no functional/mechanistic experiments were reported for this circRNA."	0.5416
30791568	International journal of molecular sciences	2019	Systematical Identification of Breast Cancer-Related Circular RNA Modules for Deciphering circRNA Functions Based on the Non-Negative Matrix Factorization Algorithm.	hsa_circ_0006528				breast cancer 	MONDO:0007254	breast cancer	unknown	RNA-seq	This study computationally identifies breast-cancer-related circRNA modules from RNA-seq and prioritizes hsa_circ_0006528 as a breast cancer_related circRNA within the inferred functional modules.	0.1768
30795787	Journal of experimental & clinical cancer research : CR	2019	CircSETD3 (Hsa_circ_0000567) acts as a sponge for microRNA-421 inhibiting hepatocellular carcinoma growth.	hsa_circ_0000567	hsa_circRNA_101436	hsa_circ_SETD3	SETD3	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"circSETD3 (hsa_circRNA_0000567/hsa_circRNA_101436) is down-regulated in hepatocellular carcinoma and functions as a tumor suppressor by inhibiting proliferation and inducing G1/S arrest. Mechanistically, it acts as a ceRNA sponge for miR-421, thereby relieving miR-421-mediated repression of MAPK14 and suppressing HCC growth in vitro and in a cell line-derived xenograft model. Clinically, low circSETD3 expression is associated with worse RFS/OS and adverse clinicopathologic features."	0.8711
30796202	Cell death & disease	2019	Circular RNA circBACH2 plays a role in papillary thyroid carcinoma by sponging miR-139-5p and regulating LMO4 expression.	hsa_circ_0001627		hsa_circ_BACH2	BACH2	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circBACH2 (hsa_circ_0001627), derived from BACH2, is up-regulated in papillary thyroid carcinoma and mainly localizes to the cytoplasm. It promotes PTC proliferation, migration, invasion and in vivo tumor growth by sponging miR-139-5p and de-repressing LMO4, forming a circBACH2/miR-139-5p/LMO4 ceRNA axis. High circBACH2 expression is associated with worse overall survival and shows diagnostic potential (AUC 0.8631)."	0.807
30796204	Cell death & disease	2019	circHIPK3 regulates lung fibroblast-to-myofibroblast transition by functioning as a competing endogenous RNA.	hsa_circ_0000284		hsa_circ_HIPK3	HIPK3	pulmonary fibrosis 	MONDO:0002771	pulmonary fibrosis	up-regulated	RT-qPCR; ISH	"circHIPK3 is up-regulated in bleomycin-induced pulmonary fibrosis, TGF-beta1-induced fibroblast-to-myofibroblast transition, and IPF patient lungs. It promotes FMT and fibroblast proliferation by sponging miR-338-3p (Ago2-dependent), increasing SOX4 and COL1A1 expression; circHIPK3 knockdown alleviates fibrosis in vivo."	0.7663
30796204	Cell death & disease	2019	circHIPK3 regulates lung fibroblast-to-myofibroblast transition by functioning as a competing endogenous RNA.	mmu_circ_0001052		mmu_circ_HIPK3	HIPK3	pulmonary fibrosis	MONDO:0002771	pulmonary fibrosis	up-regulated	RT-qPCR	"Mouse circHIPK3 (mmu_circ_0001052) is up-regulated in bleomycin-induced pulmonary fibrosis lungs. In vivo knockdown reduces fibrotic collagen deposition and lowers SOX4/COL1A1 expression, supporting a profibrotic role."	0.6306
30802235	Medical science monitor : international medical journal of experimental and clinical research	2019	Circular RNA hsa_circ_0000885 Levels are Increased in Tissue and Serum Samples from Patients with Osteosarcoma.	hsa_circ_0000885				osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000885 is upregulated in osteosarcoma tissues and patient serum, correlates with advanced stage and lung metastasis, and is associated with worse disease-free and overall survival. It may serve as a diagnostic biomarker (serum) and a prognostic biomarker for osteosarcoma."	0.6518
30809316	Theranostics	2019	CircHMGCS1 Promotes Hepatoblastoma Cell Proliferation by Regulating the IGF Signaling Pathway and Glutaminolysis.	hsa_circ_0072391	circHMGCS1	hsa_circ_HMGCS1	HMGCS1	hepatoblastoma 	MONDO:0018666	hepatoblastoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circHMGCS1 (hsa_circ_0072391) is up-regulated in hepatoblastoma tissues/cells and mainly localized in the cytoplasm. It promotes HB proliferation, survival, tumor growth and glutaminolysis by sponging miR-503-5p to increase IGF2/IGF1R and activate PI3K/AKT signaling, and high circHMGCS1 predicts poorer overall survival with diagnostic potential."	0.7533
30815012	Frontiers in genetics	2019	CircRNAs Are Here to Stay: A Perspective on the MLL Recombinome.			hsa_circ_KMT2A	KMT2A	MLL rearranged acute leukemia 	MONDO:0850450	mixed phenotype acute leukemia with MLL rearranged	down-regulated	RNA-seq	circKMT2A (exons 7_8) is abundant in normal mature blood cell populations but is suggested to be downregulated/absent in MLLre leukemic contexts due to KMT2A translocation breakpoints disrupting circRNA formation.	0.1768
30815012	Frontiers in genetics	2019	CircRNAs Are Here to Stay: A Perspective on the MLL Recombinome.			hsa_circ_AFF1	AFF1	MLL rearranged acute leukemia 	MONDO:0850450	mixed phenotype acute leukemia with MLL rearranged	unknown	RNA-seq	"circAFF1 (exons 2_3) is the dominant circular isoform from AFF1 in normal hematopoiesis; the paper suggests AFF1 breakpoint regions in MLLre would likely prevent its generation from the chimeric fusion gene, but does not quantify its level in leukemia samples."	0.1768
30815012	Frontiers in genetics	2019	CircRNAs Are Here to Stay: A Perspective on the MLL Recombinome.			hsa_circ_MLLT1	MLLT1	MLL rearranged acute leukemia 	MONDO:0850450	mixed phenotype acute leukemia with MLL rearranged	down-regulated	RNA-seq	"circMLLT1 (exons 2_4) is expressed in mature normal blood populations but is not detected in leukemic cells with KMT2A-MLLT1 fusions, consistent with translocation breakpoints preventing its formation from the derivative gene."	0.1768
30815012	Frontiers in genetics	2019	CircRNAs Are Here to Stay: A Perspective on the MLL Recombinome.		f-circM9			MLL rearranged acute leukemia 	MONDO:0850450	mixed phenotype acute leukemia with MLL rearranged	unknown	RNA-seq	"The paper discusses fusion-derived circRNA f-circM9 from KMT2A-MLLT3, noting prior reports of oncogenic potential and drug-resistance promotion, and relates its sequence to circKMT2A but does not provide new mechanistic validation here."	0.1155
30816430	International journal of molecular medicine	2019	Circular RNA expression profiles in neonatal rats following hypoxic-ischemic brain damage.		chr13: 31092209|31209056	rno_circ_Cdh7	Cdh7	hypoxic-ischemic brain damage 	MONDO:0005299	brain ischemia	up-regulated	RT-qPCR; RNA-seq	"chr13: 31092209|31209056 (host gene Cdh7) is up-regulated in the hippocampus of neonatal rat HIBD models versus sham controls, supported by RNA-seq and validated by RT-qPCR. Its miRNA-related role is only bioinformatically predicted in this study without circRNA-specific mechanistic validation."	0.3684
30816430	International journal of molecular medicine	2019	Circular RNA expression profiles in neonatal rats following hypoxic-ischemic brain damage.		chr1: 200899066|201028171	rno_circ_Ate1	Ate1	hypoxic-ischemic brain damage 	MONDO:0005299	brain ischemia	up-regulated	RT-qPCR; RNA-seq	"chr1: 200899066|201028171 (host gene Ate1) is up-regulated in hippocampus after neonatal rat HIBD and is validated by RT-qPCR. Bioinformatics predicts it may bind miR-126a, miR-9a and miR-26a, suggesting a potential miRNA-sponge role related to neuronal apoptosis, but downstream targets were not experimentally established."	0.3684
30816430	International journal of molecular medicine	2019	Circular RNA expression profiles in neonatal rats following hypoxic-ischemic brain damage.		chr11: 34065887|34070810	rno_circ_Morc3	Morc3	hypoxic-ischemic brain damage 	MONDO:0005299	brain ischemia	down-regulated	RT-qPCR; RNA-seq	"chr11: 34065887|34070810 (host gene Morc3) is significantly down-regulated in the hippocampus after neonatal rat HIBD, supported by RNA-seq and validated by RT-qPCR. No circRNA-specific downstream mechanism was experimentally confirmed beyond general bioinformatic interaction prediction performed in the study."	0.3684
30816430	International journal of molecular medicine	2019	Circular RNA expression profiles in neonatal rats following hypoxic-ischemic brain damage.		chr10: 13931236|13935484	rno_circ_Pkd1	Pkd1	hypoxic-ischemic brain damage 	MONDO:0005299	brain ischemia	down-regulated	RT-qPCR; RNA-seq	"chr10: 13931236|13935484 (host gene Pkd1) is significantly down-regulated in the hippocampus after neonatal rat HIBD, supported by RNA-seq and validated by RT-qPCR. No specific downstream mechanism for this circRNA was experimentally validated in the paper."	0.3684
30816541	Oncology reports	2019	Reconstruction and analysis of circRNA_miRNA_mRNA network in the pathology of cervical cancer.		hsa_circRNA_000596	hsa_circ_ADAMTS17	ADAMTS17	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	Microarray	"hsa_circRNA_000596 is upregulated in cervical cancer and is predicted to act as a ceRNA by sponging hsa-miR-15b to regulate hub genes including CHEK1, CEP55, KIF23 and RACGAP1 within a constructed circRNA-miRNA-mRNA network."	0.1768
30816541	Oncology reports	2019	Reconstruction and analysis of circRNA_miRNA_mRNA network in the pathology of cervical cancer.		hsa_circRNA_400068	hsa_circ_RANBP1	RANBP1	cervical cancer 	MONDO:0002974	cervical cancer	down-regulated	Microarray	"hsa_circRNA_400068 is downregulated in cervical cancer and is predicted to act as a ceRNA by binding hsa-miR-15b, thereby connecting to hub genes CHEK1, CEP55, KIF23 and RACGAP1 in the constructed network."	0.1768
30816541	Oncology reports	2019	Reconstruction and analysis of circRNA_miRNA_mRNA network in the pathology of cervical cancer.		hsa_circRNA_104315	hsa_circ_ISPD	ISPD	cervical cancer 	MONDO:0002974	cervical cancer	down-regulated	Microarray	"hsa_circRNA_104315 is downregulated in cervical cancer and is predicted to sponge hsa-miR-15b, connecting to hub genes CHEK1, CEP55, KIF23 and RACGAP1 in the circRNA-miRNA-hubgene subnetwork."	0.1768
30816541	Oncology reports	2019	Reconstruction and analysis of circRNA_miRNA_mRNA network in the pathology of cervical cancer.		hsa_circRNA_101958	hsa_circ_UBE2G1	UBE2G1	cervical cancer 	MONDO:0002974	cervical cancer	down-regulated	Microarray	"hsa_circRNA_101958 is downregulated in cervical cancer and is predicted to act as a ceRNA by binding hsa-miR-106b, thereby linking to hub genes including RRM2, ATAD2, KIF11, KIF23 and RACGAP1 in the network."	0.1768
30816541	Oncology reports	2019	Reconstruction and analysis of circRNA_miRNA_mRNA network in the pathology of cervical cancer.		hsa_circRNA_103519	hsa_circ_ZNF639	ZNF639	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	Microarray	"hsa_circRNA_103519 is upregulated in cervical cancer and is predicted to act as a ceRNA by binding hsa-miR-106b, thereby connecting to hub genes such as RRM2, ATAD2, KIF11, KIF23 and RACGAP1 in the constructed network."	0.1768
30820544	Nucleic acids research	2019	circ-Sirt1 controls NF-kappaB activation via sequence-specific interaction and enhancement of SIRT1 expression by binding to miR-132/212 in vascular smooth muscle cells.	hsa_circ_0093887		hsa_circ_SIRT1	SIRT1	atherosclerosis	MONDO:0005311	atherosclerosis	down-regulated	RT-qPCR; ISH	"circ-Sirt1 is down-regulated in vascular injury/atherosclerosis-related settings and suppresses VSMC inflammatory phenotypic switching. Mechanistically, it directly binds NF-kappaB p65 to limit nuclear translocation and sponges miR-132/212 to increase SIRT1, thereby reducing p65 acetylation and NF-kappaB transcriptional activity. Its decreased level in patient tissues/plasma suggests biomarker potential in atherosclerosis/CAD."	0.802
30838031	Frontiers in genetics	2019	Integrative Analysis Reveals Key Circular RNA in Atrial Fibrillation.		chr9:15474007-15490122			atrial fibrillation 	MONDO:0004981	atrial fibrillation	dysregulated	RNA-seq	"chr9:15474007-15490122 is identified as a key dysregulated circRNA in atrial fibrillation from lymphocyte RNA-seq data. Network-based enrichment links it to inflammatory response, particularly cytokine-cytokine receptor interaction, potentially via ceRNA/PPI-integrated regulatory context involving genes such as CCR5."	0.1768
30838031	Frontiers in genetics	2019	Integrative Analysis Reveals Key Circular RNA in Atrial Fibrillation.		chr16:75445723-75448593			atrial fibrillation 	MONDO:0004981	atrial fibrillation	dysregulated	RNA-seq	"chr16:75445723-75448593 is highlighted among top circRNAs in atrial fibrillation based on RNA-seq integrative network enrichment. It is linked to inflammatory response, particularly cytokine-cytokine receptor interaction, within a predicted ceRNA/PPI merged network."	0.1768
30838031	Frontiers in genetics	2019	Integrative Analysis Reveals Key Circular RNA in Atrial Fibrillation.	hsa_circ_0007256				atrial fibrillation 	MONDO:0004981	atrial fibrillation	dysregulated	RNA-seq	"hsa_circ_0007256 is a top-ranked dysregulated circRNA in atrial fibrillation identified from lymphocyte RNA-seq data. Integrative enrichment of the predicted ceRNA/PPI merged network connects it to inflammatory response, particularly cytokine-cytokine receptor interaction (including CCR5-related genes)."	0.1768
30838031	Frontiers in genetics	2019	Integrative Analysis Reveals Key Circular RNA in Atrial Fibrillation.		chr12:56563313-56563992			atrial fibrillation 	MONDO:0004981	atrial fibrillation	dysregulated	RNA-seq	"chr12:56563313-56563992 is identified as a top dysregulated circRNA in atrial fibrillation by integrative RNA-seq network enrichment. It is implicated in inflammatory response, particularly cytokine-cytokine receptor interaction, in the predicted ceRNA/PPI merged network context."	0.1768
30838031	Frontiers in genetics	2019	Integrative Analysis Reveals Key Circular RNA in Atrial Fibrillation.	hsa_circ_0003533				atrial fibrillation 	MONDO:0004981	atrial fibrillation	dysregulated	RNA-seq	"hsa_circ_0003533 is a top dysregulated circRNA in atrial fibrillation identified from lymphocyte RNA-seq data. Enrichment of genes connected to it in the merged ceRNA/PPI network links it to inflammation-related programs (e.g., RIG-I like receptor signaling pathway)."	0.1768
30842902	PeerJ	2019	"Salvianolic acid B plays an anti-obesity role in high fat diet-induced obese mice by regulating the expression of mRNA, circRNA, and lncRNA."		chr7:67264864_67268400-			obesity 	MONDO:0011122	obesity disorder	up-regulated	RT-qPCR; RNA-seq	"This circRNA (chr7:67264864_67268400:-) was identified as differentially expressed in epididymal white adipose tissue of HFD-induced obese mice after Salvianolic acid B treatment. Its up-regulation in the Sal B group versus the obesity model group was validated by RT-qPCR, suggesting it may be associated with Sal B¡¯s anti-obesity effects, although no downstream mechanism was established."	0.4625
30843267	Journal of clinical laboratory analysis	2019	Aberrant expression of serum circANRIL and hsa_circ_0123996 in children with Kawasaki disease.			hsa_circ_ANRIL	ANRIL	Kawasaki disease 	MONDO:0012727	Kawasaki disease	down-regulated	RT-qPCR	Serum circANRIL is decreased in acute Kawasaki disease compared with healthy controls and increases after IVIG therapy. It shows modest diagnostic performance and is proposed as a potential early diagnostic biomarker for KD.	0.4187
30843267	Journal of clinical laboratory analysis	2019	Aberrant expression of serum circANRIL and hsa_circ_0123996 in children with Kawasaki disease.	hsa_circ_0123996		hsa_circ_FBXW12	FBXW12	Kawasaki disease 	MONDO:0012727	Kawasaki disease	up-regulated	RT-qPCR	Serum hsa_circ_0123996 is elevated in acute Kawasaki disease compared with healthy controls and does not change after IVIG therapy. It shows moderate diagnostic performance and is proposed as a potential early diagnostic biomarker for KD.	0.4187
30857544	Journal of translational medicine	2019	Circular RNA hsa_circ_0055538 regulates the malignant biological behavior of oral squamous cell carcinoma through the p53/Bcl-2/caspase signaling pathway.	hsa_circ_0055538		hsa_circ_RMND5A	RMND5A	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0055538 is down-regulated in OSCC tissues and cell lines. Its overexpression suppresses proliferation, migration, invasion and xenograft tumor growth while promoting apoptosis, likely via activation of the p53/Bcl-2/caspase axis; it may also negatively regulate its host gene RMND5A."	0.6545
30861600	Journal of clinical laboratory analysis	2019	Up-regulation of circular RNA hsa_circ_0037909 promotes essential hypertension.	hsa_circ_0037909		hsa_circ_GSPT1	GSPT1	Essential hypertension 	MONDO:0001134	essential hypertension	up-regulated	RT-qPCR; Microarray	"hsa_circ_0037909 is up-regulated in essential hypertension patient blood and in TNF-alpha-treated endothelial cells, and is inversely associated with hsa-miR-637. The study suggests a circRNA/miRNA regulatory relationship and supports its potential as an early diagnostic biomarker (especially combined with hsa-miR-637), with correlations to LDL and serum creatinine."	0.5047
30863152	Cancer management and research	2019	Circular RNA circHIPK3 promotes cell proliferation and invasion of prostate cancer by sponging miR-193a-3p and regulating MCL1 expression.	hsa_circ_0000284		hsa_circ_HIPK3	HIPK3	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in prostate cancer and functions as an oncogenic circRNA. It mainly localizes to the cytoplasm and sponges miR-193a-3p, thereby increasing MCL1 expression to promote proliferation, migration/invasion, and xenograft tumor growth; higher circHIPK3 levels are associated with advanced tumor stage and poor prognosis."	0.8146
30866608	Turkish journal of medical sciences	2019	Down-regulation of circular RNA ITCH and circHIPK3 in gastric cancer tissues.			hsa_circ_ITCH	ITCH	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"cir_ITCH is significantly down-regulated in gastric cancer tumoral tissues versus paired adjacent nontumoral tissues, and its expression is associated with clinicopathological features. The study suggests it may serve as a potential prognostic biomarker, but does not define a specific mechanism in GC."	0.5129
30866608	Turkish journal of medical sciences	2019	Down-regulation of circular RNA ITCH and circHIPK3 in gastric cancer tissues.			hsa_circ_HIPK3	HIPK3	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"circHIPK3 is significantly down-regulated in gastric cancer tumoral tissues compared with paired adjacent nontumoral tissues, and its levels correlate with clinicopathological parameters (e.g., age and metastasis-related features). The study proposes circHIPK3 as a potential prognostic biomarker in GC but does not experimentally define its mechanism in GC."	0.5129
30881124	Cancer management and research	2019	"Upregulated circ RNA hsa_circ_0000337 promotes cell proliferation, migration, and invasion of esophageal squamous cell carcinoma."	hsa_circ_0000337	hsa_circRNA_100872	hsa_circ_PPFIA1	PPFIA1	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000337 is up-regulated in ESCC tissues and promotes ESCC cell proliferation, migration, and invasion. Mechanistically, it functions as a miRNA sponge for miR-670-5p, supporting a circRNA_miRNA_mRNA regulatory axis with predicted downstream targets."	0.6815
30884120	Journal of cellular and molecular medicine	2019	Inhibition of circular RNA CDR1as increases chemosensitivity of 5-FU-resistant BC cells through up-regulating miR-7.		CDR1as / CiRS-7	hsa_circ_CDR1	CDR1	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"CDR1as is up-regulated in 5-FU-resistant breast cancer cells and promotes 5-FU chemoresistance. Mechanistically, CDR1as sponges miR-7, leading to increased CCNE1 expression, enhanced proliferation/colony formation, reduced apoptosis, and faster xenograft tumor growth under 5-FU treatment."	0.5992
30887698	Journal of cellular and molecular medicine	2019	circEPSTI1 regulates ovarian cancer progression via decoying miR-942.			hsa_circ_EPSTI1	EPSTI1	ovarian cancer	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circEPSTI1 is up-regulated in ovarian cancer tissues and promotes malignant phenotypes (proliferation, invasion, tumor growth/metastasis) while inhibiting apoptosis. Mechanistically, it mainly localizes to the cytoplasm and acts as a ceRNA that sponges miR-942 to upregulate EPSTI1."	0.73
30896864	Molecular medicine reports	2019	circEIF4G2 modulates the malignant features of cervical cancer via the miR_218/HOXA1 pathway.	hsa_circ_0021254		hsa_circ_EIF4G2	EIF4G2	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circEIF4G2 is up-regulated in cervical cancer tissues and cell lines and is associated with poor prognosis. Functionally, circEIF4G2 promotes proliferation, colony formation, migration and invasion. Mechanistically, it sponges miR-218 to increase HOXA1 expression, forming a circEIF4G2/miR-218/HOXA1 regulatory axis."	0.7789
30922402	Molecular cancer	2019	Circular RNA circ-DONSON facilitates gastric cancer growth and invasion via NURF complex dependent activation of transcription factor SOX4.	hsa_circ_0004339		hsa_circ_DONSON	DONSON	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Northern Blot; ISH; Microarray	"circ-DONSON (hsa_circ_0004339) is upregulated in gastric cancer and its high expression is associated with advanced stage and poor survival. Functionally, it promotes proliferation, migration/invasion and tumor growth while inhibiting apoptosis. Mechanistically, nuclear circ-DONSON binds SNF2L and recruits the NURF complex to the SOX4 promoter to activate SOX4 transcription."	0.8419
30923232	Annals of the rheumatic diseases	2019	CircSERPINE2 protects against osteoarthritis by targeting miR-1271 and ETS-related gene.	hsa_circ_0008365		hsa_circ_SERPINE2	SERPINE2	osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR; Northern Blot; ISH; RNA-seq	"CircSERPINE2 is down-regulated in osteoarthritis cartilage and mainly localizes to the cytoplasm. It functions as a ceRNA by sponging miR-1271 to upregulate ERG, thereby reducing chondrocyte apoptosis and restoring ECM anabolic/catabolic balance; AAV-mediated overexpression alleviates OA pathology in an ACLT rabbit model."	0.8408
30925892	Molecular cancer	2019	A novel protein encoded by a circular RNA circPPP1R12A promotes tumor pathogenesis and metastasis of colon cancer via Hippo-YAP signaling.	hsa_circ_0000423		hsa_circ_PPP1R12A	PPP1R12A	colon cancer 	MONDO:0021063	malignant colon neoplasm	up-regulated	RT-qPCR; ISH; Microarray	"circPPP1R12A (hsa_circ_0000423), derived from PPP1R12A, is up-regulated in colon cancer tissues/cell lines and mainly localized in the cytoplasm. It contains an ORF that encodes a 73-aa peptide (circPPP1R12A-73aa), which promotes colon cancer proliferation and metastasis by activating Hippo/YAP signaling, and higher circPPP1R12A levels are associated with worse overall survival."	0.7987
30927924	Molecular cancer	2019	Circular RNA AKT3 upregulates PIK3R1 to enhance cisplatin resistance in gastric cancer via miR-198 suppression.	hsa_circ_0000199		hsa_circ_AKT3	AKT3	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"circAKT3 (hsa_circ_0000199) is up-regulated in cisplatin-resistant gastric cancer tissues/cells and promotes CDDP resistance. It acts mainly in the cytoplasm as a miR-198 sponge to upregulate PIK3R1, activate PI3K/AKT signaling, enhance DNA damage repair (BRCA1-related), and inhibit apoptosis; high circAKT3 predicts worse DFS and may serve as a biomarker/target for CDDP-treated GC."	0.8908
30930980	Oncology letters	2019	In silico detection of potential prognostic circRNAs through a re-annotation strategy in ovarian cancer.	hsa_circ_0031356				ovarian cancer 	MONDO:0008170	ovarian cancer	unknown	Microarray	"circ_0031356 is one component of a six-circRNA prognostic signature in ovarian cancer; higher expression is associated with better overall survival (protective). Its potential function was inferred via co-expression-based enrichment, including association with the spliceosome pathway."	0.459
30930980	Oncology letters	2019	In silico detection of potential prognostic circRNAs through a re-annotation strategy in ovarian cancer.	hsa_circ_0093477				ovarian cancer 	MONDO:0008170	ovarian cancer	unknown	Microarray	0093477/circ_0093477 is part of a six-circRNA prognostic signature in ovarian cancer; higher expression corresponds to better overall survival (protective). Co-expression enrichment linked it to neuroactive ligand-receptor interaction and ribosome pathways.	0.459
30930980	Oncology letters	2019	In silico detection of potential prognostic circRNAs through a re-annotation strategy in ovarian cancer.	hsa_circ_0110166				ovarian cancer 	MONDO:0008170	ovarian cancer	unknown	Microarray	0110166/circ_0110166 is part of a six-circRNA prognostic signature in ovarian cancer; higher expression is associated with better overall survival. Enrichment analysis linked it to the spliceosome pathway.	0.459
30930980	Oncology letters	2019	In silico detection of potential prognostic circRNAs through a re-annotation strategy in ovarian cancer.	hsa_circ_0126526				ovarian cancer 	MONDO:0008170	ovarian cancer	unknown	Microarray	0126526/circ_0126526 is part of a six-circRNA prognostic signature in ovarian cancer; higher expression is associated with better overall survival. Co-expression enrichment linked it to the spliceosome pathway and to endometrial cancer and other signaling-related gene sets.	0.459
30930980	Oncology letters	2019	In silico detection of potential prognostic circRNAs through a re-annotation strategy in ovarian cancer.	hsa_circ_0130590				ovarian cancer 	MONDO:0008170	ovarian cancer	unknown	Microarray	0130590/circ_0130590 is part of a six-circRNA prognostic signature in ovarian cancer; higher expression is associated with better overall survival. Co-expression enrichment linked it to neuroactive ligand-receptor interaction and ribosome pathways.	0.459
30930980	Oncology letters	2019	In silico detection of potential prognostic circRNAs through a re-annotation strategy in ovarian cancer.	hsa_circ_0135175				ovarian cancer 	MONDO:0008170	ovarian cancer	unknown	Microarray	0135175/circ_0135175 is part of a six-circRNA prognostic signature in ovarian cancer; higher expression is associated with better overall survival. Enrichment analysis linked it to the spliceosome pathway.	0.459
30937532	Archives of gynecology and obstetrics	2019	Circular RNA expression profiling of granulosa cells in women of reproductive age with polycystic ovary syndrome.	hsa_circ_0001577		hsa_circ_RANBP9	RANBP9	polycystic ovary syndrome 	MONDO:0008487	polycystic ovary syndrome	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0001577 is significantly up-regulated in granulosa cells from women of reproductive age with PCOS versus controls based on RNA-seq and qRT-PCR validation. Its functional mechanism in PCOS was not determined in this study.	0.5541
30937532	Archives of gynecology and obstetrics	2019	Circular RNA expression profiling of granulosa cells in women of reproductive age with polycystic ovary syndrome.	hsa_circ_0020093		hsa_circ_ATRNL1	ATRNL1	polycystic ovary syndrome 	MONDO:0008487	polycystic ovary syndrome	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0020093 is down-regulated in granulosa cells from women of reproductive age with PCOS versus controls, validated by qRT-PCR. The study did not define its downstream targets or mechanism in PCOS."	0.5541
30940151	Molecular cancer	2019	Circular RNA circTADA2A promotes osteosarcoma progression and metastasis by sponging miR-203a-3p and regulating CREB3 expression.	hsa_circ_0043278		hsa_circ_TADA2A	TADA2A	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; ISH; Microarray	"circTADA2A (hsa_circ_0043278), derived from TADA2A exons 5 and 6, is up-regulated in osteosarcoma tissues and cell lines and mainly localizes in the cytoplasm. It promotes osteosarcoma cell proliferation, migration, invasion, tumorigenesis and metastasis while suppressing apoptosis by acting as a miR-203a-3p sponge to increase CREB3 expression (circTADA2A/miR-203a-3p/CREB3 axis)."	0.8379
30946694	Aging	2019	Elevation of circular RNA circ_0005230 facilitates cell growth and metastasis via sponging miR-1238 and miR-1299 in cholangiocarcinoma.	hsa_circ_0005230		hsa_circ_DNM3OS	DNM3OS	cholangiocarcinoma 	MONDO:0019087	cholangiocarcinoma	up-regulated	RT-qPCR	"circ_0005230 is up-regulated in cholangiocarcinoma tissues and cell lines and is associated with more aggressive clinicopathologic features. Functionally, it promotes proliferation, migration/invasion and in vivo tumor growth/metastasis while inhibiting apoptosis, at least partly by sponging miR-1238 and miR-1299."	0.713
30947518	Circulation	2019	Loss of Super-Enhancer-Regulated circRNA Nfix Induces Cardiac Regeneration After Myocardial Infarction in Adult Mice.	mmu_circ_0001704		mmu_circ_Nfix	Nfix	myocardial infarction 	MONDO:0005068	myocardial infarction	up-regulated	RT-qPCR; ISH; RNA-seq	"circNfix is a super-enhancer- and Meis1-regulated cardiac circRNA whose downregulation promotes post-MI cardiac repair by increasing cardiomyocyte proliferation and angiogenesis and reducing apoptosis. Mechanistically, circNfix facilitates Ybx1 ubiquitin-dependent degradation via Nedd4l and also sponges miR-214 to modulate the miR-214/Gsk3beta/beta-catenin axis."	0.8657
30947518	Circulation	2019	Loss of Super-Enhancer-Regulated circRNA Nfix Induces Cardiac Regeneration After Myocardial Infarction in Adult Mice.	hsa_circ_0005660				myocardial infarction 	MONDO:0005068	myocardial infarction	up-regulated	RT-qPCR; ISH; RNA-seq	"circNfix is a super-enhancer- and Meis1-regulated cardiac circRNA whose downregulation promotes post-MI cardiac repair by increasing cardiomyocyte proliferation and angiogenesis and reducing apoptosis. Mechanistically, circNfix facilitates Ybx1 ubiquitin-dependent degradation via Nedd4l and also sponges miR-214 to modulate the miR-214/Gsk3beta/beta-catenin axis."	0.8657
30948703	Medical science monitor : international medical journal of experimental and clinical research	2019	Identification of Key Genes and Circular RNAs in Human Gastric Cancer.	hsa_circ_0000332		hsa_circ_PC	PC	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	Microarray	"hsa_circ_0000332 is identified by integrated analysis of three GEO circRNA microarray datasets as down-regulated in gastric cancer tissue versus adjacent non-tumor tissue. The study predicts its miRNA binding partners and constructs a circRNA_miRNA_mRNA regulatory network, but provides no experimental functional validation."	0.1768
30948703	Medical science monitor : international medical journal of experimental and clinical research	2019	Identification of Key Genes and Circular RNAs in Human Gastric Cancer.	hsa_circ_0021087		hsa_circ_LMO1	LMO1	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	Microarray	"hsa_circ_0021087 is identified by integrated analysis of three GEO circRNA microarray datasets as down-regulated in gastric cancer tissue versus adjacent non-tumor tissue. The study predicts its miRNA interactions and builds a circRNA_miRNA_mRNA network, suggesting it may be a more central circRNA node in this network due to more predicted interactions, but no experimental validation is provided."	0.1768
30953514	Molecular cancer	2019	CircDLST promotes the tumorigenesis and metastasis of gastric cancer by sponging miR-502-5p and activating the NRAS/MEK1/ERK1/2 signaling.	hsa_circ_0032627		hsa_circ_DLST	DLST	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; ISH	"circDLST is up-regulated in gastric cancer and mainly localized in the cytoplasm. It promotes GC cell proliferation, invasion, and metastasis by sponging miR-502-5p, releasing NRAS and activating the NRAS/MEK1/ERK1/2 pathway, and its high expression predicts poor survival."	0.8427
30956729	Disease markers	2019	circSMARCA5 Functions as a Diagnostic and Prognostic Biomarker for Gastric Cancer.			hsa_circ_SMARCA5	SMARCA5	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"circSMARCA5 is down-regulated in gastric cancer tissues, cell lines, and patient plasma. Functionally, circSMARCA5 acts as a tumor suppressor by inhibiting proliferation, migration, and invasion of gastric cancer cells. Clinically, low circSMARCA5 is associated with worse OS/DFS and it shows diagnostic potential (AUC 0.806)."	0.7621
30963578	Journal of cellular physiology	2019	FNDC3B circular RNA promotes the migration and invasion of gastric cancer cells via the regulation of E-cadherin and CD44 expression.	hsa_circ_0006156		hsa_circ_FNDC3B	FNDC3B	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"In gastric cancer cell lines, circFNDC3B promotes migration and invasion and facilitates EMT by reducing E-cadherin protein. Mechanistically, it binds IGF2BP3 and CD44 mRNA to form a ternary complex that elevates CD44 expression, and it also shows protein-coding activity producing an ~25 kD peptide."	0.74
30979827	Bioscience reports	2019	Silencing of hsa_circ_0004771 inhibits proliferation and induces apoptosis in breast cancer through activation of miR-653 by targeting ZEB2 signaling pathway.	hsa_circ_0004771				breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0004771 is up-regulated in breast cancer tissues/cell lines and promotes tumor cell growth. Silencing hsa_circ_0004771 inhibits proliferation and induces apoptosis in vitro and suppresses xenograft growth in vivo. Mechanistically, hsa_circ_0004771 sponges miR-653 to relieve repression of ZEB2, forming a hsa_circ_0004771/miR-653/ZEB2 ceRNA axis; high hsa_circ_0004771 is associated with poorer overall survival."	0.8158
30979827	Bioscience reports	2019	Silencing of hsa_circ_0004771 inhibits proliferation and induces apoptosis in breast cancer through activation of miR-653 by targeting ZEB2 signaling pathway.	hsa_circ_0102273				breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0102273 was identified by circRNA sequencing as up-regulated in breast cancer tumor tissues and its increase was validated by RT-qPCR in clinical tissue pairs; no downstream mechanism or functional assays were reported for this circRNA.	0.5531
30979827	Bioscience reports	2019	Silencing of hsa_circ_0004771 inhibits proliferation and induces apoptosis in breast cancer through activation of miR-653 by targeting ZEB2 signaling pathway.	hsa_circ_0102272				breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0102272 was identified by circRNA sequencing as up-regulated in breast cancer tumor tissues and its increase was validated by RT-qPCR in clinical tissue pairs; no downstream mechanism or functional assays were reported for this circRNA.	0.5531
30979827	Bioscience reports	2019	Silencing of hsa_circ_0004771 inhibits proliferation and induces apoptosis in breast cancer through activation of miR-653 by targeting ZEB2 signaling pathway.	hsa_circ_0103021				breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0103021 was identified by circRNA sequencing as up-regulated in breast cancer tumor tissues and its increase was validated by RT-qPCR in clinical tissue pairs; no downstream mechanism or functional assays were reported for this circRNA.	0.5531
30979827	Bioscience reports	2019	Silencing of hsa_circ_0004771 inhibits proliferation and induces apoptosis in breast cancer through activation of miR-653 by targeting ZEB2 signaling pathway.	hsa_circ_0100213				breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0100213 was identified by circRNA sequencing as up-regulated in breast cancer tumor tissues and its increase was validated by RT-qPCR in clinical tissue pairs; no downstream mechanism or functional assays were reported for this circRNA.	0.5531
30983072	Cell proliferation	2019	Circular RNA DOCK1 promotes bladder carcinoma progression via modulating circDOCK1/hsa-miR-132-3p/Sox5 signalling pathway.	hsa_circ_0020394		hsa_circ_DOCK1	DOCK1	bladder carcinoma 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"circDOCK1 (hsa_circ_0020394), derived from DOCK1, is up-regulated in bladder carcinoma tissues/cell lines and promotes malignant phenotypes (viability, proliferation, migration) and xenograft growth. Mechanistically, it functions as a miRNA sponge for hsa-miR-132-3p, relieving repression of Sox5 and forming the circDOCK1/miR-132-3p/Sox5 ceRNA axis."	0.6783
30984788	BioMed research international	2019	Low Expression of hsa_circ_0018069 in Human Bladder Cancer and Its Clinical Significance.	hsa_circ_0018069		hsa_circ_KIAA1462	KIAA1462	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0018069 is significantly downregulated in bladder cancer tissues and cell lines. Bioinformatics/ceRNA analysis suggests it may act as a tumor suppressor by sponging miR-23c/miR-34a-5p/miR-181b-5p/miR-454-3p/miR-3666 and regulating targets such as PPP1R12B, implicating focal adhesion and related tumorigenesis pathways. Lower expression correlates with more aggressive clinicopathological features and shows potential diagnostic value (ROC AUC 0.709)."	0.5047
30988068	Bioscience reports	2019	CircLMTK2 acts as a novel tumor suppressor in gastric cancer.	hsa_circ_0001725		hsa_circ_LMTK2	LMTK2	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; RNA-seq	"circLMTK2 (hsa_circ_0001725), derived from LMTK2, is down-regulated in gastric cancer tissues and several GC cell lines. Functionally, circLMTK2 overexpression suppresses viability and migration/invasion and promotes apoptosis (with increased Bax/cleaved Caspase 3 and decreased Bcl-2). Clinically, higher circLMTK2 expression correlates with longer overall survival and is an independent prognostic factor."	0.785
30988074	Bioscience reports	2019	Hsa_circ_0004370 promotes esophageal cancer progression through miR-1294/LASP1 pathway.	hsa_circ_0004370		hsa_circ_PRRX1	PRRX1	esophageal cancer 	MONDO:0007576	esophageal cancer	up-regulated	RT-qPCR	"hsa_circ_0004370 is up-regulated in esophageal cancer tissues and cell lines and promotes malignant behaviors (proliferation and invasion) while inhibiting apoptosis. Mechanistically, it sponges miR-1294 to relieve repression of LASP1, forming the hsa_circ_0004370/miR-1294/LASP1 axis."	0.7032
30988274	Medical science monitor : international medical journal of experimental and clinical research	2019	Identification of Altered Circular RNA Expression in Serum Exosomes from Patients with Papillary Thyroid Carcinoma by High-Throughput Sequencing.		hsa-circ-007293			papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsacirc_007293 is up-regulated in serum exosomes from patients with papillary thyroid carcinoma versus benign goiter controls. Its differential expression was identified by high-throughput sequencing and confirmed by RT-qPCR, suggesting potential diagnostic relevance, though no specific mechanism was validated."	0.4032
30988274	Medical science monitor : international medical journal of experimental and clinical research	2019	Identification of Altered Circular RNA Expression in Serum Exosomes from Patients with Papillary Thyroid Carcinoma by High-Throughput Sequencing.		hsa-circ-031752			papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsacirc_031752 is up-regulated in serum exosomes from patients with papillary thyroid carcinoma versus benign goiter controls, with consistent results between RNA-seq and RT-qPCR. The study suggests potential diagnostic biomarker value but does not validate a specific downstream mechanism."	0.4032
30988274	Medical science monitor : international medical journal of experimental and clinical research	2019	Identification of Altered Circular RNA Expression in Serum Exosomes from Patients with Papillary Thyroid Carcinoma by High-Throughput Sequencing.		hsa-circ-020135			papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsacirc_020135 is up-regulated in serum exosomes from papillary thyroid carcinoma patients compared with benign goiter controls, and this change was detected by RNA-seq and confirmed by RT-qPCR. The paper does not establish a specific miRNA/mRNA mechanism for this circRNA."	0.4032
30988674	Cellular & molecular biology letters	2019	Hypoxia-associated circDENND2A promotes glioma aggressiveness by sponging miR-625-5p.	hsa_circ_0002142		hsa_circ_DENND2A	DENND2A	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"In glioma cells under hypoxia, circDENND2A is induced and accumulates in the cytoplasm, where it promotes migratory and invasive phenotypes. Mechanistically, circDENND2A acts as a sponge for miR-625-5p, influencing downstream targets such as AKT2, and its expression is associated with HIF1alpha-high glioma tissues."	0.8082
30999937	Journal of experimental & clinical cancer research : CR	2019	Circular RNA hsa_circ_0068871 regulates FGFR3 expression and activates STAT3 by targeting miR-181a-5p to promote bladder cancer progression.	hsa_circ_0068871		hsa_circ_FGFR3	FGFR3	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"hsa_circ_0068871 is up-regulated in bladder cancer and promotes proliferation, migration, and xenograft growth while reducing apoptosis. It functions as a ceRNA sponge for miR-181a-5p, relieving repression of FGFR3 and activating STAT3 signaling, and may serve as a biomarker."	0.8571
31010208	International journal of molecular sciences	2019	Dysregulation of Circular RNAs in Myotonic Dystrophy Type 1.		circASPH	hsa_circ_ASPH	ASPH	myotonic dystrophy type 1 	MONDO:0008056	myotonic dystrophy type 1	up-regulated	RT-qPCR; RNA-seq	"circASPH is significantly increased in DM1 skeletal muscle biopsies (biceps brachii) compared with controls, identified via RNA-seq and validated by RT-qPCR. It is part of a DM1-circRNA signature evaluated for discriminating DM1 from controls by ROC analysis."	0.5047
31010208	International journal of molecular sciences	2019	Dysregulation of Circular RNAs in Myotonic Dystrophy Type 1.		circCDYL	hsa_circ_CDYL	CDYL	myotonic dystrophy type 1 	MONDO:0008056	myotonic dystrophy type 1	up-regulated	RT-qPCR; RNA-seq	"circCDYL is up-regulated in DM1 skeletal muscle, with an increased circular-to-linear ratio independent of its linear transcript. Its circular fraction/ratio correlates with clinical muscle strength and splicing biomarkers, and shows diagnostic discrimination between DM1 and controls by ROC analysis."	0.5047
31010208	International journal of molecular sciences	2019	Dysregulation of Circular RNAs in Myotonic Dystrophy Type 1.		circHIPK3	hsa_circ_HIPK3	HIPK3	myotonic dystrophy type 1 	MONDO:0008056	myotonic dystrophy type 1	up-regulated	RT-qPCR; RNA-seq	"circHIPK3 is increased in DM1 skeletal muscle, with an increased circular-to-linear ratio, and its circular fraction correlates with muscle strength and disease severity/splicing biomarkers. The paper also notes known miRNA-sponge activity of circHIPK3 (miR-29b/miR-193a/miR-30a), suggesting a potential ceRNA-related role, though not functionally tested in DM1 here."	0.5047
31010208	International journal of molecular sciences	2019	Dysregulation of Circular RNAs in Myotonic Dystrophy Type 1.		circRTN4_03	hsa_circ_RTN4	RTN4	myotonic dystrophy type 1 	MONDO:0008056	myotonic dystrophy type 1	up-regulated	RT-qPCR; RNA-seq	"circRTN4_03 is significantly increased in DM1 skeletal muscle and shows an increased circular-to-linear ratio, suggesting dysregulation beyond linear RTN4 expression. It is also increased in differentiated DM1 myogenic cell cultures, and its levels/ratio correlate with splicing biomarkers and clinical muscle strength measures."	0.5047
31010208	International journal of molecular sciences	2019	Dysregulation of Circular RNAs in Myotonic Dystrophy Type 1.		circZNF609	hsa_circ_ZNF609	ZNF609	myotonic dystrophy type 1 	MONDO:0008056	myotonic dystrophy type 1	up-regulated	RT-qPCR; RNA-seq	"circZNF609 is up-regulated in DM1 skeletal muscle and shows an increased circular-to-linear ratio. Its circular fraction correlates with muscle strength, and it contributes to diagnostic discrimination of DM1 vs controls by ROC analysis; in myogenic cells, its circular-to-linear ratio (but not circular transcript alone) is significantly increased."	0.5849
31012177	Cell proliferation	2019	Circular RNA cMras inhibits lung adenocarcinoma progression via modulating miR-567/PTPRG regulatory pathway.	hsa_circ_0067512	cMras	hsa_circ_Mras	Mras	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR	"cMras is down-regulated in LUAD and functions as a tumor suppressor by inhibiting proliferation, migration, invasion and in vivo metastasis. Mechanistically, it acts as a miR-567 sponge to de-repress PTPRG, forming a cMras/miR-567/PTPRG regulatory axis."	0.8532
31027518	Genome biology	2019	Translation of the circular RNA circbeta-catenin promotes liver cancer cell growth through activation of the Wnt pathway.	hsa_circ_0004194	circbeta-catenin	hsa_circ_CTNNB1	beta-catenin	liver cancer 	MONDO:0002691	liver cancer	up-regulated	RT-qPCR; Northern Blot	"circbeta-catenin is up-regulated in HCC and promotes malignant phenotypes (proliferation, cell cycle progression, migration/invasion, tumor growth and metastasis). Mechanistically, it encodes beta-catenin-370aa, which binds GSK3beta and stabilizes full-length beta-catenin to activate Wnt/beta-catenin signaling."	0.8661
31035951	BMC cancer	2019	Hsa_circ_0005379 regulates malignant behavior of oral squamous cell carcinoma through the EGFR pathway.	hsa_circ_0005379				oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005379 is down-regulated in OSCC and acts as a tumor suppressor by inhibiting proliferation, migration, invasion, EMT and angiogenesis while promoting apoptosis. It negatively regulates EGFR/p-EGFR signaling and increases OSCC sensitivity to cetuximab."	0.7376
31036604	Bioscience reports	2019	Differential expression and bioinformatics analysis of circRNA in osteosarcoma.		circ_32279			osteosarcoma	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; RNA-seq	"circ_32279 is significantly down-regulated in osteosarcoma tumor tissues compared with paracancerous/adjacent tissues, supported by RNA-seq screening and RT-qPCR validation in clinical samples."	0.5135
31036604	Bioscience reports	2019	Differential expression and bioinformatics analysis of circRNA in osteosarcoma.		circ_24831			osteosarcoma	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; RNA-seq	"circ_24831 is significantly down-regulated in osteosarcoma tumor tissues versus paracancerous tissues, supported by RNA-seq screening and RT-qPCR validation in clinical samples."	0.5135
31036604	Bioscience reports	2019	Differential expression and bioinformatics analysis of circRNA in osteosarcoma.		circ_2137			osteosarcoma	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; RNA-seq	"circ_2137 is significantly up-regulated in osteosarcoma tumor tissues compared with paracancerous tissues, supported by RNA-seq screening and RT-qPCR validation in clinical samples."	0.5135
31036604	Bioscience reports	2019	Differential expression and bioinformatics analysis of circRNA in osteosarcoma.		circ_20403			osteosarcoma	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; RNA-seq	"circ_20403 is significantly up-regulated in osteosarcoma tumor tissues compared with adjacent/paracancerous tissues, supported by RNA-seq screening and RT-qPCR validation in clinical samples."	0.5135
31043588	Cell death & disease	2019	Angiotensin II inhibits apoptosis of mouse aortic smooth muscle cells through regulating the circNRG-1/miR-193b-5p/NRG-1 axis.		mmu-circRNA-42742	mmu_circ_NRG-1	NRG-1	vascular remodeling 	MONDO:0005385	vascular disorder	down-regulated	RT-qPCR; Microarray	"In MASMCs under Ang II stimulation, circNRG-1 is down-regulated. circNRG-1 normally sponges miR-193b-5p to support NRG-1 expression; reduced circNRG-1 permits miR-193b-5p-mediated suppression of NRG-1, contributing to Ang II-induced apoptosis resistance and vascular remodeling-related effects."	0.7211
31046163	Cancer science	2019	circMAN1A2 could serve as a novel serum biomarker for malignant tumors.		circMAN1A2	hsa_circ_MAN1A2	MAN1A2	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"circMAN1A2 is significantly up-regulated in patient serum across several malignancies (NPC, oral, thyroid, ovarian, and lung cancer) and shows diagnostic potential by ROC analysis. A ceRNA-style mechanism (binding miRNAs, especially hsa-miR-135a-3p, with predicted downstream targets) is proposed but not experimentally validated in this study."	0.459
31046163	Cancer science	2019	circMAN1A2 could serve as a novel serum biomarker for malignant tumors.		circMAN1A2	hsa_circ_MAN1A2	MAN1A2	oral cancer	MONDO:0044925	oral cavity carcinoma	up-regulated	RT-qPCR	"circMAN1A2 is significantly up-regulated in patient serum across several malignancies (NPC, oral, thyroid, ovarian, and lung cancer) and shows diagnostic potential by ROC analysis. A ceRNA-style mechanism (binding miRNAs, especially hsa-miR-135a-3p, with predicted downstream targets) is proposed but not experimentally validated in this study."	0.459
31046163	Cancer science	2019	circMAN1A2 could serve as a novel serum biomarker for malignant tumors.		circMAN1A2	hsa_circ_MAN1A2	MAN1A2	thyroid cancer	MONDO:0002108	thyroid cancer	up-regulated	RT-qPCR	"circMAN1A2 is significantly up-regulated in patient serum across several malignancies (NPC, oral, thyroid, ovarian, and lung cancer) and shows diagnostic potential by ROC analysis. A ceRNA-style mechanism (binding miRNAs, especially hsa-miR-135a-3p, with predicted downstream targets) is proposed but not experimentally validated in this study."	0.459
31046163	Cancer science	2019	circMAN1A2 could serve as a novel serum biomarker for malignant tumors.		circMAN1A2	hsa_circ_MAN1A2	MAN1A2	ovarian cancer	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circMAN1A2 is significantly up-regulated in patient serum across several malignancies (NPC, oral, thyroid, ovarian, and lung cancer) and shows diagnostic potential by ROC analysis. A ceRNA-style mechanism (binding miRNAs, especially hsa-miR-135a-3p, with predicted downstream targets) is proposed but not experimentally validated in this study."	0.459
31046163	Cancer science	2019	circMAN1A2 could serve as a novel serum biomarker for malignant tumors.		circMAN1A2	hsa_circ_MAN1A2	MAN1A2	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circMAN1A2 is significantly up-regulated in patient serum across several malignancies (NPC, oral, thyroid, ovarian, and lung cancer) and shows diagnostic potential by ROC analysis. A ceRNA-style mechanism (binding miRNAs, especially hsa-miR-135a-3p, with predicted downstream targets) is proposed but not experimentally validated in this study."	0.459
31048182	Molecular therapy. Nucleic acids	2019	Circular RNA circCHFR Facilitates the Proliferation and Migration of Vascular Smooth Muscle via miR-370/FOXO1/Cyclin D1 Pathway.	hsa_circ_0029589		hsa_circ_CHFR	CHFR	atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR; Microarray	"circCHFR (hsa_circ_0029589, host gene CHFR) is up-regulated in ox-LDL-induced human VSMCs and promotes VSMC proliferation and migration. Mechanistically, it sponges miR-370 to increase FOXO1, and FOXO1 transcriptionally activates CCND1, elevating Cyclin D1."	0.657
31072448	BMB reports	2020	Circular RNA hsa_circ_0075828 promotes bladder cancer cell proliferation through activation of CREB1.	hsa_circ_0075828		hsa_circ_CASC15	CASC15	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0075828 (circCASC15), derived from CASC15, is up-regulated in bladder cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes bladder cancer proliferation in vitro and in vivo by sponging miR-1224-5p and thereby activating CREB1 expression; higher circCASC15 expression is associated with advanced tumor stage and poorer OS/DFS."	0.8523
31076544	Bioscience reports	2019	Up-regulated circular RNA VANGL1 contributes to progression of non-small cell lung cancer through inhibition of miR-195 and activation of Bcl-2.			hsa_circ_VANGL1	VANGL1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circVANGL1 is up-regulated in NSCLC tissues/cell lines and promotes malignant phenotypes (proliferation, migration, invasion) while inhibiting apoptosis. Mechanistically, it functions as a ceRNA that sponges miR-195 to increase Bcl-2 expression, and high circVANGL1 correlates with poorer overall survival."	0.7113
31086464	World journal of gastroenterology	2019	Role and mechanism of circ-PRKCI in hepatocellular carcinoma.			hsa_circ_PRKCI	PRKCI	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ-PRKCI is up-regulated in HCC tissues and HCC cell lines. It promotes malignant phenotypes (invasion and proliferation) and inhibits apoptosis, at least partly by acting as a miR-545 sponge to modulate AKT3 protein, with downstream association to E2F7-related prognosis."	0.7357
31092884	Cell death and differentiation	2019	Translation of yes-associated protein (YAP) was antagonized by its circular RNA via suppressing the assembly of the translation initiation machinery.			hsa_circ_YAP1	Yap1	breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	"circYap (from YAP1) is down-regulated in breast cancer tissues and mainly localized in the cytoplasm. It binds Yap mRNA and the translation initiation factors PABP/eIF4G to disrupt their interaction, thereby suppressing YAP translation and inhibiting malignant phenotypes (proliferation, colony formation, migration/invasion)."	0.8075
31095447	"Cell cycle (Georgetown, Tex.)"	2019	Hsa_circ_0101432 promotes the development of hepatocellular carcinoma (HCC) by adsorbing miR-1258 and miR-622.	hsa_circ_0101432		hsa_circ_RPPH1	RPPH1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0101432 is up-regulated in HCC tissues/cell lines and promotes HCC progression. Mechanistically, it sponges miR-1258 and miR-622 to relieve repression of MAPK1, enhancing proliferation and invasion while inhibiting apoptosis, and it promotes tumor growth in a nude-mouse xenograft model."	0.8122
31101108	Molecular cancer	2019	Circular RNA ACVR2A suppresses bladder cancer cells proliferation and metastasis through miR-626/EYA4 axis.	hsa_circ_0001073		hsa_circ_ACVR2A	ACVR2A	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"circACVR2A (hsa_circ_0001073), derived from ACVR2A, is down-regulated in bladder cancer tissues and cell lines and mainly localizes to the cytoplasm. It suppresses bladder cancer cell proliferation, migration, invasion and in vivo tumor growth/metastasis by sponging miR-626 to upregulate EYA4. Low circACVR2A expression correlates with aggressive clinicopathological features and poorer overall survival."	0.8837
31109436	Zhongguo fei ai za zhi = Chinese journal of lung cancer	2019	[Cyclic RNA Molecule circ_0007766 Promotes the Proliferation of Lung Adenocarcinoma Cells by Up-regulating the Expression of Cyclin D1/CyclinE1/CDK4].	hsa_circ_0007766		hsa_circ_ERBB2	ERBB2	lung adenocarcinoma	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circ_0007766 is up-regulated in lung adenocarcinoma tissues and cell lines. Its knockdown suppresses proliferation and migration and induces G0/G1 arrest. Mechanistically, it binds the RBP eIF4A3 and is associated with increased Cyclin D1/Cyclin E1/CDK4 expression to promote cell-cycle progression."	0.6829
31110542	Archives of medical science : AMS	2019	Differential expression study of circular RNAs in exosomes from serum and urine in patients with idiopathic membranous nephropathy.		chr7:100550808|100551062	hsa_circ_MUC3A	MUC3A	idiopathic membranous nephropathy 	MONDO:0005376	membranous glomerulonephritis	up-regulated	RNA-seq	This exosomal circRNA derived from MUC3A (chr7:100550808|100551062) is significantly up-regulated in serum exosomes from IMN patients and is proposed as a potential diagnostic biomarker. The paper speculates it may contribute to IMN pathogenesis through the mannose-binding lectin pathway and possible association with IgG4/anti-PLA2R antibody-related processes.	0.4874
31118036	Molecular cancer	2019	Circular RNA F-circSR derived from SLC34A2-ROS1 fusion gene promotes cell migration in non-small cell lung cancer.		F-circSR1	hsa_circ_SLC34A2-ROS1	SLC34A2-ROS1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	unknown	RT-qPCR	"In NSCLC cell models, F-circSR1 (a circular RNA generated from the SLC34A2-ROS1 fusion gene) promotes cell migration but shows little effect on proliferation. The study suggests a possible miRNA-sponge role based on predicted binding sites (miR-150-5p/miR-194-3p/miR-515-5p), but this mechanism was not functionally validated."	0.7822
31118036	Molecular cancer	2019	Circular RNA F-circSR derived from SLC34A2-ROS1 fusion gene promotes cell migration in non-small cell lung cancer.		F-circSR2	hsa_circ_SLC34A2-ROS1	SLC34A2-ROS1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	unknown	RT-qPCR	"In NSCLC cell models, F-circSR2 (generated from the SLC34A2-ROS1 fusion gene) promotes cell migration while having little effect on proliferation. A potential miRNA-sponge mechanism was proposed based on bioinformatic prediction of miRNA binding sites, without direct functional validation."	0.6562
31118688	OncoTargets and therapy	2019	CircHIPK3 overexpression accelerates the proliferation and invasion of prostate cancer cells through regulating miRNA-338-3p.			hsa_circ_HIPK3	HIPK3	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"In prostate cancer, circHIPK3 is up-regulated and promotes proliferation and invasion. Mechanistically, it sponges miRNA-338-3p to relieve repression of ADAM17, thereby accelerating malignant progression."	0.6479
31123169	Bioscience reports	2019	"Knockdown of hsa_circ_0023028 inhibits cell proliferation, migration, and invasion in laryngeal cancer by sponging miR-194-5p."	hsa_circ_0023028		hsa_circ_C11orf80	C11orf80	laryngeal cancer 	MONDO:0002358	laryngeal carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0023028 is up-regulated in laryngeal cancer tissues and cell lines and acts as an oncogenic circRNA. Its knockdown suppresses proliferation, migration, and invasion, and it directly sponges miR-194-5p as supported by luciferase assays and rescue experiments using a miR-194-5p inhibitor."	0.6777
31127091	Nature communications	2019	Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus.		HPV16 circE7			cervical cancer	MONDO:0002974	cervical cancer	unknown	RT-qPCR; Northern Blot; RNA-seq	"HPV16 circE7 is a virus-derived, m6A-modified circRNA enriched in the cytoplasm and associated with polysomes. It is translated to produce the E7 oncoprotein, and circE7 depletion reduces E7 protein levels and suppresses CaSki cell proliferation and xenograft tumor growth."	0.8519
31127091	Nature communications	2019	Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus.		HPV18 circE7			cervical cancer	MONDO:0002974	cervical cancer	unknown	RNA-seq	"HPV18 circE7 was identified computationally from RNA-seq (including SW-756 cells and TCGA HPV-positive tumors), but it was not robustly detectable by RT-PCR or northern blot in tested HPV18+ cell lines; no functional/mechanistic assays were reported for HPV18 circE7."	0.1768
31127091	Nature communications	2019	Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus.		HPV31 circE7			cervical cancer	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR	"HPV31 circE7 is detectable in HPV31 infection models (HPV31-transfected keratinocytes and CIN612). Its level decreases upon calcium-induced epithelial differentiation, suggesting circE7 is regulated by the differentiation state relevant to the HPV life cycle."	0.279
31127091	Nature communications	2019	Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus.		HPV16 circE7			tongue squamous cell cancer	MONDO:0044710	lip and oral cavity squamous cell carcinoma	unknown	RT-qPCR; Northern Blot; RNA-seq	"HPV16 circE7 is a virus-derived, m6A-modified circRNA enriched in the cytoplasm and associated with polysomes. It is translated to produce the E7 oncoprotein, and circE7 depletion reduces E7 protein levels and suppresses CaSki cell proliferation and xenograft tumor growth."	0.8519
31127091	Nature communications	2019	Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus.		HPV18 circE7			tongue squamous cell cancer	MONDO:0044710	lip and oral cavity squamous cell carcinoma	unknown	RNA-seq	"HPV18 circE7 was identified computationally from RNA-seq (including SW-756 cells and TCGA HPV-positive tumors), but it was not robustly detectable by RT-PCR or northern blot in tested HPV18+ cell lines; no functional/mechanistic assays were reported for HPV18 circE7."	0.1768
31127091	Nature communications	2019	Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus.		HPV31 circE7			tongue squamous cell cancer	MONDO:0044710	lip and oral cavity squamous cell carcinoma	down-regulated	RT-qPCR	"HPV31 circE7 is detectable in HPV31 infection models (HPV31-transfected keratinocytes and CIN612). Its level decreases upon calcium-induced epithelial differentiation, suggesting circE7 is regulated by the differentiation state relevant to the HPV life cycle."	0.279
31127091	Nature communications	2019	Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus.		HPV16 circE7			cervical squamous cell carcinoma and endocervical adenocarcinoma	MONDO:0005131	cervical carcinoma	unknown	RT-qPCR; Northern Blot; RNA-seq	"HPV16 circE7 is a virus-derived, m6A-modified circRNA enriched in the cytoplasm and associated with polysomes. It is translated to produce the E7 oncoprotein, and circE7 depletion reduces E7 protein levels and suppresses CaSki cell proliferation and xenograft tumor growth."	0.8519
31127091	Nature communications	2019	Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus.		HPV18 circE7			cervical squamous cell carcinoma and endocervical adenocarcinoma	MONDO:0005131	cervical carcinoma	unknown	RNA-seq	"HPV18 circE7 was identified computationally from RNA-seq (including SW-756 cells and TCGA HPV-positive tumors), but it was not robustly detectable by RT-PCR or northern blot in tested HPV18+ cell lines; no functional/mechanistic assays were reported for HPV18 circE7."	0.1768
31127091	Nature communications	2019	Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus.		HPV31 circE7			cervical squamous cell carcinoma and endocervical adenocarcinoma	MONDO:0005131	cervical carcinoma	down-regulated	RT-qPCR	"HPV31 circE7 is detectable in HPV31 infection models (HPV31-transfected keratinocytes and CIN612). Its level decreases upon calcium-induced epithelial differentiation, suggesting circE7 is regulated by the differentiation state relevant to the HPV life cycle."	0.279
31127091	Nature communications	2019	Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus.		HPV16 circE7			head and neck squamous cell carcinoma 	MONDO:0010150	head and neck squamous cell carcinoma	unknown	RT-qPCR; Northern Blot; RNA-seq	"HPV16 circE7 is a virus-derived, m6A-modified circRNA enriched in the cytoplasm and associated with polysomes. It is translated to produce the E7 oncoprotein, and circE7 depletion reduces E7 protein levels and suppresses CaSki cell proliferation and xenograft tumor growth."	0.8519
31127091	Nature communications	2019	Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus.		HPV18 circE7			head and neck squamous cell carcinoma 	MONDO:0010150	head and neck squamous cell carcinoma	unknown	RNA-seq	"HPV18 circE7 was identified computationally from RNA-seq (including SW-756 cells and TCGA HPV-positive tumors), but it was not robustly detectable by RT-PCR or northern blot in tested HPV18+ cell lines; no functional/mechanistic assays were reported for HPV18 circE7."	0.1768
31127091	Nature communications	2019	Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus.		HPV31 circE7			head and neck squamous cell carcinoma 	MONDO:0010150	head and neck squamous cell carcinoma	down-regulated	RT-qPCR	"HPV31 circE7 is detectable in HPV31 infection models (HPV31-transfected keratinocytes and CIN612). Its level decreases upon calcium-induced epithelial differentiation, suggesting circE7 is regulated by the differentiation state relevant to the HPV life cycle."	0.279
31127091	Nature communications	2019	Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus.		HPV16 circE7			HPV-positive cancers	MONDO:0005131	cervical carcinoma	unknown	RT-qPCR; Northern Blot; RNA-seq	"HPV16 circE7 is a virus-derived, m6A-modified circRNA enriched in the cytoplasm and associated with polysomes. It is translated to produce the E7 oncoprotein, and circE7 depletion reduces E7 protein levels and suppresses CaSki cell proliferation and xenograft tumor growth."	0.8519
31127091	Nature communications	2019	Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus.		HPV18 circE7			HPV-positive cancers	MONDO:0005131	cervical carcinoma	unknown	RNA-seq	"HPV18 circE7 was identified computationally from RNA-seq (including SW-756 cells and TCGA HPV-positive tumors), but it was not robustly detectable by RT-PCR or northern blot in tested HPV18+ cell lines; no functional/mechanistic assays were reported for HPV18 circE7."	0.1768
31127091	Nature communications	2019	Transforming activity of an oncoprotein-encoding circular RNA from human papillomavirus.		HPV31 circE7			HPV-positive cancers	MONDO:0005131	cervical carcinoma	down-regulated	RT-qPCR	"HPV31 circE7 is detectable in HPV31 infection models (HPV31-transfected keratinocytes and CIN612). Its level decreases upon calcium-induced epithelial differentiation, suggesting circE7 is regulated by the differentiation state relevant to the HPV life cycle."	0.279
31131537	Molecular oncology	2019	Circular RNA Cdr1as sensitizes bladder cancer to cisplatin by upregulating APAF1 expression through miR-1270 inhibition.		Cdr1as	hsa_circ_CDR1	CDR1	bladder cancer	MONDO:0004986	urinary bladder carcinoma	unknown	RT-qPCR	"In bladder cancer, Cdr1as increases cisplatin chemosensitivity by promoting apoptosis. Mechanistically, Cdr1as acts as a ceRNA that sponges miR-1270, relieving repression of APAF1 and increasing APAF1 expression."	0.7778
31137016	Aging	2019	Circular RNA hsa_circ_0001649 inhibits hepatocellular carcinoma progression via multiple miRNAs sponge.	hsa_circ_0001649		hsa_circ_SHPRH	SHPRH	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"hsa_circ_0001649 (circ-0001649), derived from the SHPRH locus, is down-regulated in hepatocellular carcinoma tissues and cell lines. It suppresses HCC proliferation, migration and EMT by acting as a ceRNA that sponges miR-127-5p/miR-612/miR-4688, thereby increasing SHPRH expression and inhibiting tumor growth in a xenograft model."	0.8591
31140741	Journal of cellular and molecular medicine	2019	Cigarette smoke extract alters genome-wide profiles of circular RNAs and mRNAs in primary human small airway epithelial cells.	hsa_circ_0010023				chronic obstructive pulmonary disease 	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0010023 is up-regulated in CSE-treated primary human small airway epithelial cells (a COPD-related smoke stress model). The study validates this change by RT-qPCR and includes it in a predicted circRNA-mediated ceRNA framework, but does not report a specific downstream miRNA/mRNA axis for this circRNA."	0.5466
31140741	Journal of cellular and molecular medicine	2019	Cigarette smoke extract alters genome-wide profiles of circular RNAs and mRNAs in primary human small airway epithelial cells.	hsa_circ_0040929				chronic obstructive pulmonary disease 	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0040929 is up-regulated in CSE-treated primary human small airway epithelial cells (a COPD-related smoke stress model), with RT-qPCR validation consistent with sequencing. The study does not provide a specific miRNA/mRNA target axis for this circRNA."	0.5466
31140741	Journal of cellular and molecular medicine	2019	Cigarette smoke extract alters genome-wide profiles of circular RNAs and mRNAs in primary human small airway epithelial cells.	hsa_circ_0060927				chronic obstructive pulmonary disease 	MONDO:0005002	chronic obstructive pulmonary disease	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0060927 is down-regulated in CSE-treated primary human small airway epithelial cells, and this differential expression is validated by RT-qPCR. No specific downstream miRNA/mRNA target is reported for this circRNA."	0.5466
31140741	Journal of cellular and molecular medicine	2019	Cigarette smoke extract alters genome-wide profiles of circular RNAs and mRNAs in primary human small airway epithelial cells.	hsa_circ_0002472				chronic obstructive pulmonary disease 	MONDO:0005002	chronic obstructive pulmonary disease	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0002472 is down-regulated in CSE-treated primary human small airway epithelial cells, validated by RT-qPCR. The paper does not specify its interacting miRNAs/targets."	0.5466
31140741	Journal of cellular and molecular medicine	2019	Cigarette smoke extract alters genome-wide profiles of circular RNAs and mRNAs in primary human small airway epithelial cells.	hsa_circ_0002153				chronic obstructive pulmonary disease 	MONDO:0005002	chronic obstructive pulmonary disease	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0002153 is down-regulated in CSE-treated primary human small airway epithelial cells and is RT-qPCR validated as consistent with sequencing results. No direct functional assays or specific targets are provided for this circRNA.	0.5466
31140741	Journal of cellular and molecular medicine	2019	Cigarette smoke extract alters genome-wide profiles of circular RNAs and mRNAs in primary human small airway epithelial cells.	hsa_circ_0001573				chronic obstructive pulmonary disease 	MONDO:0005002	chronic obstructive pulmonary disease	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0001573 is down-regulated under CSE stimulation in primary human small airway epithelial cells and is RT-qPCR validated. The study does not specify its molecular interactors or functional outcomes.	0.5466
31141496	Aging	2019	circFADS2 protects LPS-treated chondrocytes from apoptosis acting as an interceptor of miR-498/mTOR cross-talking.		circFADS2	rno_circ_FADS2	FADS2	Rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; Northern Blot; Microarray	"circFADS2 is up-regulated in RA cartilage and in LPS-treated chondrocytes. It protects chondrocytes from apoptosis and limits inflammatory/ECM-catabolic changes by sponging miR-498, thereby relieving miR-498-mediated repression of mTOR (circFADS2/miR-498/mTOR axis)."	0.697
31144476	Molecular genetics & genomic medicine	2019	Circular RNA expression profiles and bioinformatics analysis in ovarian endometriosis.	hsa_circ_0003380		hsa_circ_ZFPM2	ZFPM2	ovarian endometriosis 	MONDO:0006337	ovarian endometriosis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0003380 is significantly overexpressed in ectopic endometrium versus eutopic endometrium in ovarian endometriosis patients. The study predicts it may act in a ceRNA network, potentially affecting angiogenesis via a proposed hsa_circ_0003380/miR-205/VEGFA axis."	0.4032
31144476	Molecular genetics & genomic medicine	2019	Circular RNA expression profiles and bioinformatics analysis in ovarian endometriosis.	hsa_circ_0020093		hsa_circ_ATRNL1	ATRNL1	ovarian endometriosis 	MONDO:0006337	ovarian endometriosis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0020093 is significantly overexpressed in ectopic endometrium in endometriosis. The study proposes, based on ceRNA network predictions, that it may influence EMT via an inferred hsa_circ_0020093/miR-141-3p/miR-200a-3p/ZEB1 regulatory axis."	0.4032
31144476	Molecular genetics & genomic medicine	2019	Circular RNA expression profiles and bioinformatics analysis in ovarian endometriosis.	hsa_circ_0008016		hsa_circ_FGFR1	FGFR1	ovarian endometriosis 	MONDO:0006337	ovarian endometriosis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0008016 (from host gene FGFR1) is significantly overexpressed in ectopic endometrium in ovarian endometriosis. It is included in the study¡¯s predicted ceRNA network, but no specific miRNA/mRNA axis is experimentally validated for this circRNA."	0.4032
31144476	Molecular genetics & genomic medicine	2019	Circular RNA expression profiles and bioinformatics analysis in ovarian endometriosis.	hsa_circ_0077837		hsa_circ_EP B41L2	EP B41L2	ovarian endometriosis 	MONDO:0006337	ovarian endometriosis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0077837 (host gene EP B41L2) is significantly overexpressed in ectopic endometrium in ovarian endometriosis. It is part of the study¡¯s predicted ceRNA network, but specific downstream miRNA/mRNA targets are not experimentally validated for this circRNA."	0.4032
31148365	Journal of cellular and molecular medicine	2019	CircMTO1 inhibits liver fibrosis via regulation of miR-17-5p and Smad7.	hsa_circ_0007874	circMTO1	hsa_circ_MTO1	MTO1	liver fibrosis 	MONDO:0100430	fibrotic liver disease	down-regulated	RT-qPCR	"circMTO1 is down-regulated in serum of CHB patients with liver fibrosis and decreases further with increasing fibrosis/HAI scores, supporting diagnostic potential. Functionally, circMTO1 suppresses TGF-beta1-induced hepatic stellate cell activation by sponging miR-17-5p, thereby relieving repression of Smad7."	0.7972
31152142	Aging	2019	Downregulation of circ_0132266 in chronic lymphocytic leukemia promoted cell viability through miR-337-3p/PML axis.	hsa_circ_0132266	circ_0132266	hsa_circ_MTO1	MTO1	chronic lymphocytic leukemia 	MONDO:0003864	chronic lymphocytic leukemia/small lymphocytic lymphoma	down-regulated	RT-qPCR	"In CLL PBMCs, circ_0132266 is down-regulated and functions as a tumor-suppressive circRNA. It sponges miR-337-3p to relieve repression of PML, thereby inhibiting proliferation and promoting apoptosis in CLL cells."	0.8405
31153371	Molecular cancer	2019	Circular RNA circTRIM33-12 acts as the sponge of MicroRNA-191 to suppress hepatocellular carcinoma progression.			hsa_circ_TRIM33	TRIM33	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"circTRIM33_12 is down-regulated in HCC and acts as a tumor suppressor. It sponges miR-191 to relieve repression of TET1 (increasing TET1 protein), influencing 5hmC/DNA demethylation and reducing proliferation, migration/invasion, metastasis and immune evasion; low circTRIM33_12 predicts worse prognosis and recurrence risk."	0.8295
31156698	Frontiers in genetics	2019	Analyses of a Panel of Transcripts Identified From a Small Sample Size and Construction of RNA Networks in Hepatocellular Carcinoma.			hsa_circ_AKR1B10	AKR1B10	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circAKR1B10 is significantly up-regulated in HCC tumor tissues compared with paired adjacent non-tumor tissues, supported by RNA-seq and RT-qPCR validation in 21 patient pairs."	0.3588
31156698	Frontiers in genetics	2019	Analyses of a Panel of Transcripts Identified From a Small Sample Size and Construction of RNA Networks in Hepatocellular Carcinoma.			hsa_circ_AKR1C3	AKR1C3	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circAKR1C3 is significantly up-regulated in HCC tumor tissues compared with paired adjacent non-tumor tissues, supported by RNA-seq and RT-qPCR validation in 21 patient pairs."	0.3588
31156698	Frontiers in genetics	2019	Analyses of a Panel of Transcripts Identified From a Small Sample Size and Construction of RNA Networks in Hepatocellular Carcinoma.			hsa_circ_HMGCS1	HMGCS1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"circHMGCS1 is significantly down-regulated in HCC tumor tissues compared with paired adjacent non-tumor tissues, supported by RNA-seq and RT-qPCR validation in 21 patient pairs."	0.3588
31156698	Frontiers in genetics	2019	Analyses of a Panel of Transcripts Identified From a Small Sample Size and Construction of RNA Networks in Hepatocellular Carcinoma.			hsa_circ_C3P1	C3P1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"circC3P1 is significantly down-regulated in HCC tumor tissues compared with paired adjacent non-tumor tissues, supported by RNA-seq and RT-qPCR validation in 21 patient pairs."	0.3588
31157168	Frontiers in oncology	2019	CircRNA-100338 Is Associated With mTOR Signaling Pathway and Poor Prognosis in Hepatocellular Carcinoma.		hsa_circRNA-100338	hsa_circ_SNX27	SNX27	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circRNA-100338 is up-regulated in HCC and promotes tumor cell proliferation. It functions as a ceRNA for miR-141-3p, derepressing RHEB to activate mTOR/mTORC1 signaling and increase downstream EIF5, and its high expression is associated with poor prognosis in hepatitis B-related HCC."	0.7085
31160270	EBioMedicine	2019	The circRNA circPTPRA suppresses epithelial-mesenchymal transitioning and metastasis of NSCLC cells by sponging miR-96-5p.	hsa_circ_0006117	hsa_circRNA_102984	hsa_circ_PTPRA	PTPRA	non-small cell lung carcinomas 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Northern Blot; Microarray	"circPTPRA is down-regulated in NSCLC tumors and acts as a tumor-suppressive circRNA. It mainly localizes in the cytoplasm and inhibits EMT, migration/invasion, and metastasis by sponging miR-96-5p, which relieves repression of RASSF8 and supports E-cadherin expression. Low circPTPRA level associates with metastasis and poorer patient survival."	0.894
31169949	Journal of clinical laboratory analysis	2019	Expression profiles of circular RNAs in human colorectal cancer based on RNA deep sequencing.	hsa_circ_0142527		hsa_circ_PREX2	PREX2	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0142527 is significantly down-regulated in colorectal cancer tissues versus adjacent tissues and is positively correlated with KLF4, being predicted as a KLF4-related ceRNA. It shows diagnostic potential (high AUC in ROC analysis) and its expression is associated with multiple clinicopathological features including invasion, distal metastasis, and TNM stage."	0.6556
31175544	Molecular neurobiology	2019	Circular RNAs as Potential Blood Biomarkers in Amyotrophic Lateral Sclerosis.	hsa_circ_0000567		hsa_circ_SETD3	SETD3	Amyotrophic lateral sclerosis 	MONDO:0004976	amyotrophic lateral sclerosis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000567 is significantly up-regulated in PBMC/leukocyte samples from ALS patients by RT-qPCR. Its expression correlates negatively with patient age, suggesting possible clinical relevance as a blood biomarker, though it was not among the top AUC circRNAs."	0.5135
31175544	Molecular neurobiology	2019	Circular RNAs as Potential Blood Biomarkers in Amyotrophic Lateral Sclerosis.	hsa_circ_0005218		hsa_circ_FAM120A	FAM120A	Amyotrophic lateral sclerosis 	MONDO:0004976	amyotrophic lateral sclerosis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0005218 is significantly up-regulated in ALS PBMC/leukocyte samples by RT-qPCR, and higher levels are associated with greater functional impairment in patients."	0.5135
31175544	Molecular neurobiology	2019	Circular RNAs as Potential Blood Biomarkers in Amyotrophic Lateral Sclerosis.	hsa_circ_0035796		hsa_circ_HERC1	HERC1	Amyotrophic lateral sclerosis 	MONDO:0004976	amyotrophic lateral sclerosis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0035796 is significantly up-regulated in ALS PBMC/leukocyte samples by RT-qPCR, supporting its dysregulation in ALS, but no specific mechanism or clinical diagnostic performance is reported for it."	0.5135
31175544	Molecular neurobiology	2019	Circular RNAs as Potential Blood Biomarkers in Amyotrophic Lateral Sclerosis.	hsa_circ_0043138		hsa_circ_TAF15	TAF15	Amyotrophic lateral sclerosis 	MONDO:0004976	amyotrophic lateral sclerosis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0043138 is significantly up-regulated in ALS PBMC/leukocyte samples by RT-qPCR, indicating dysregulation in ALS; however, the study does not report a specific mechanism or prognostic/diagnostic performance for this circRNA."	0.5135
31175544	Molecular neurobiology	2019	Circular RNAs as Potential Blood Biomarkers in Amyotrophic Lateral Sclerosis.	hsa_circ_0063411		hsa_circ_TNRC6B	TNRC6B	Amyotrophic lateral sclerosis 	MONDO:0004976	amyotrophic lateral sclerosis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0063411 (TNRC6B-derived) is up-regulated in ALS blood leukocytes/PBMCs and shows strong diagnostic performance (AUC > 0.95). It is clinically associated with functional impairment and shows negative correlation with disease duration and survival time; mechanistically, it is predicted to bind hsa-miR-647."	0.5963
31175544	Molecular neurobiology	2019	Circular RNAs as Potential Blood Biomarkers in Amyotrophic Lateral Sclerosis.	hsa_circ_0088036	hsa_circRNA_104871	hsa_circ_SUSD1	SUSD1	Amyotrophic lateral sclerosis 	MONDO:0004976	amyotrophic lateral sclerosis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0088036 (SUSD1-derived) is up-regulated in ALS blood leukocytes/PBMCs and has strong diagnostic potential (AUC > 0.95, sensitivity/specificity > 90%). Its expression is negatively associated with patient age."	0.5963
31175544	Molecular neurobiology	2019	Circular RNAs as Potential Blood Biomarkers in Amyotrophic Lateral Sclerosis.	hsa_circ_0023919		hsa_circ_PICALM	PICALM	Amyotrophic lateral sclerosis 	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR; Microarray	"hsa_circ_0023919 (PICALM-derived) is down-regulated in ALS blood leukocytes/PBMCs and shows strong diagnostic potential (AUC > 0.95). It is predicted to contain binding sites for hsa-miR-9, suggesting a possible miRNA-sponge relationship, but this mechanism is not functionally validated in the study."	0.5963
31179240	Frontiers in oncology	2019	CircPCMTD1 Acts as the Sponge of miR-224-5p to Promote Glioma Progression.	hsa_circ_0001801		hsa_circ_PCMTD1	PCMTD1	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circPCMTD1 is up-regulated in glioma and promotes proliferation/viability, migration, and invasion. Mechanistically, it mainly localizes to the cytoplasm and functions as a ceRNA sponge for miR-224-5p, thereby increasing mTOR expression and enhancing glioma progression; its knockdown suppresses xenograft tumor growth."	0.7009
31182759	Scientific reports	2019	Detection of novel biomarkers for early detection of Non-Muscle-Invasive Bladder Cancer using Competing Endogenous RNA network analysis.	hsa_circ_0017586		hsa_circ_GDI2	GDI2	Non-Muscle-Invasive Bladder Cancer 	MONDO:0004986	urinary bladder carcinoma	unknown	RNA-seq	This study computationally identified hsa_circ_0017586 (host gene GDI2) as a hub/altered circRNA potentially related to NMIBC. Network analysis suggested it may act via a ceRNA mechanism by sponging miR-107 (shared with hsa_circ_0003221 and hsa_circ_0001741).	0.348
31182759	Scientific reports	2019	Detection of novel biomarkers for early detection of Non-Muscle-Invasive Bladder Cancer using Competing Endogenous RNA network analysis.	hsa_circ_0001741		hsa_circ_TNPO3	TNPO3	Non-Muscle-Invasive Bladder Cancer 	MONDO:0004986	urinary bladder carcinoma	unknown	RNA-seq	This study computationally identified hsa_circ_0001741 (host gene TNPO3) as a hub/altered circRNA potentially related to NMIBC. Network analysis suggested it may act via a ceRNA mechanism by sponging miR-107 (shared with hsa_circ_0003221 and hsa_circ_0017586).	0.348
31182928	International journal of biological sciences	2019	Circular RNA CircCACTIN Promotes Gastric Cancer Progression by Sponging MiR-331-3p and Regulating TGFBR1 Expression.	hsa_circ_0092303		hsa_circ_CACTIN	CACTIN	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circCACTIN (hsa_circ_0092303) is up-regulated in gastric cancer tissues and cell lines and promotes malignant phenotypes (migration/invasion, EMT, and xenograft tumor growth). It acts as a ceRNA by sponging miR-331-3p, thereby increasing TGFBR1 expression and engaging the TGF-beta/EMT program."	0.7855
31185953	BMC cancer	2019	Silencing of ANKRD12 circRNA induces molecular and functional changes associated with invasive phenotypes.			hsa_circ_ANKRD12	ANKRD12	ovarian cancer 	MONDO:0008170	ovarian cancer	unknown	RT-qPCR; RNA-seq	"circANKRD12 is a cytoplasmic, RNase R_resistant circRNA derived from ANKRD12 that is abundant across multiple cancer cell lines. siRNA knockdown of circANKRD12 drives a phenotypic switch featuring reduced proliferation and G0/G1 arrest but increased migration/invasion, with decreased oxidative phosphorylation. The study suggests a potential ceRNA mechanism involving shared miRNA binding with Cyclin D1 (e.g., hsa-miR-4768-5p) and proposes biomarker potential."	0.7011
31186686	Oncology letters	2019	Circular RNA ATXN7 is upregulated in non-small cell lung cancer and promotes disease progression.			hsa_circ_ATXN7	ATXN7	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circATXN7 is upregulated in NSCLC tumor tissues. Functional knockdown experiments indicate circATXN7 promotes NSCLC cell proliferation and invasion in vitro, supporting an oncogenic role; its miRNA-sponge mechanism is proposed but not validated in this study."	0.7353
31189743	Bioscience reports	2019	High-throughput sequencing reveals circular RNA hsa_circ_0000592 as a novel player in the carcinogenesis of gastric carcinoma.	hsa_circ_0000592				gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"hsa_circ_0000592 is up-regulated in MNNG-induced malignant-transformed gastric epithelial cells and multiple gastric cancer cell lines. Its knockdown suppresses proliferation, induces G0/G1 arrest, increases apoptosis, and reduces migration, and it is mainly cytoplasmic, suggesting a potential ceRNA/miRNA-sponging role and possible diagnostic biomarker potential in gastric carcinoma."	0.6157
31190886	OncoTargets and therapy	2019	Circular RNA CDR1as acts as a sponge of miR-135b-5p to suppress ovarian cancer progression.			hsa_circ_CDR1		ovarian cancer	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR	"CDR1as is down-regulated in ovarian cancer tissues/cells and suppresses ovarian cancer cell proliferation, invasion and migration. Mechanistically, it sponges miR-135b-5p to relieve repression of HIF1AN, contributing to a tumor-inhibitory effect."	0.5758
31191816	Oncotarget	2019	circPSMC3: ceRNA and tumor suppressor.			hsa_circ_PSMC3	PSMC3	Gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	Microarray	"circPSMC3 is down-regulated in gastric cancer tissues/plasma and is associated with advanced TNM stage and shorter overall survival. Mechanistically, it functions as a ceRNA by sponging miR-296-5p to regulate PTEN, thereby suppressing gastric cancer tumorigenesis and showing potential as a circulating biomarker."	0.5261
31194163	Molecular therapy oncolytics	2019	The Pharmacological Effects of Spatholobi Caulis Tannin in Cervical Cancer and Its Precise Therapeutic Effect on Related circRNA.	hsa_circ_0067641		hsa_circ_ATR	ATR	cervical cancer	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR	"In HeLa cervical cancer cells, SCT treatment decreases circATR expression in a dose-dependent manner. The study links SCT-modulated circATR (together with other circRNAs) to reduced proliferation, cell-cycle arrest, and increased apoptosis."	0.5416
31194163	Molecular therapy oncolytics	2019	The Pharmacological Effects of Spatholobi Caulis Tannin in Cervical Cancer and Its Precise Therapeutic Effect on Related circRNA.	hsa_circ_0036868		hsa_circ_BLM	BLM	cervical cancer	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR	SCT treatment reduces circBLM expression in HeLa cervical cancer cells. The study associates modulation of circBLM (as one of the SCT-regulated circRNAs) with inhibited proliferation/cell-cycle progression and increased apoptosis.	0.5416
31194163	Molecular therapy oncolytics	2019	The Pharmacological Effects of Spatholobi Caulis Tannin in Cervical Cancer and Its Precise Therapeutic Effect on Related circRNA.	hsa_circ_0075804		hsa_circ_E2F3	E2F3	cervical cancer	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR	"circE2F3 is downregulated by SCT in HeLa cervical cancer cells. The study predicts circE2F3-miRNA binding (miRNA sponge potential) and suggests circE2F3 as a main therapeutic target among the examined circRNAs, in the context of SCT-driven growth inhibition and apoptosis promotion."	0.5416
31194163	Molecular therapy oncolytics	2019	The Pharmacological Effects of Spatholobi Caulis Tannin in Cervical Cancer and Its Precise Therapeutic Effect on Related circRNA.	hsa_circ_0006971		hsa_circ_FANCB	FANCB	cervical cancer	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR	circFANCB is downregulated by SCT in HeLa cervical cancer cells. The study predicts binding between circFANCB and hsa-miR-4692 and links SCT-regulated circFANCB (as part of the circRNA set) to inhibited growth and promoted apoptosis in HeLa cells.	0.5416
31195953	"Molecular medicine (Cambridge, Mass.)"	2019	CircRNA-9119 suppresses poly I:C induced inflammation in Leydig and Sertoli cells via TLR3 and RIG-I signal pathways.		circRNA-9119			orchitis 	MONDO:0006882	orchitis	up-regulated	RT-qPCR; Microarray	"In a poly I:C-induced murine orchitis/testicular inflammation model, circRNA-9119 is upregulated in testes (especially in Leydig and Sertoli cells). It functions as a ceRNA sponge for miR-26a and miR-136, thereby increasing TLR3 and RIG-I expression and promoting inflammatory cytokine production."	0.6815
31197975	Cancer medicine	2019	Circular RNA screening from EIF3a in lung cancer.	hsa_circ_0004350		hsa_circ_EIF3A	EIF3a	lung cancer	MONDO:0008903	lung cancer	dysregulated	RT-qPCR	"hsa_circ_0004350 is differentially expressed between A549 and cisplatin-resistant A549/DDP lung cancer cells. Knockdown of hsa_circ_0004350 affects cisplatin resistance, and bioinformatic/experimental evidence suggests it mainly functions through RBP-associated processes linked to translation regulation rather than AGO2/miRNA-mediated mechanisms."	0.6579
31197975	Cancer medicine	2019	Circular RNA screening from EIF3a in lung cancer.	hsa_circ_0092857		hsa_circ_EIF3A	EIF3a	lung cancer	MONDO:0008903	lung cancer	dysregulated	RT-qPCR	"hsa_circ_0092857 is differentially expressed between A549 and cisplatin-resistant A549/DDP lung cancer cells. Its downregulation alters cisplatin resistance, and the study suggests an RBP-related mechanism connected to translation regulation with little evidence for AGO2/miRNA-sponge activity."	0.6579
31199037	Cell proliferation	2019	Circ-SERPINE2 promotes the development of gastric carcinoma by sponging miR-375 and modulating YWHAZ.	hsa_circ_0008365		hsa_circ_SERPINE2	SERPINE2	gastric carcinoma 	MONDO:0004950	gastric carcinoma	up-regulated	RT-qPCR; Microarray	"In gastric carcinoma, circ-SERPINE2 (hsa_circ_0008365) is up-regulated and promotes proliferation and cell-cycle progression while inhibiting apoptosis. Mechanistically, it acts as a ceRNA that sponges miR-375 to increase YWHAZ expression, and circ-SERPINE2 knockdown suppresses xenograft tumour growth."	0.8571
31207308	Life sciences	2019	Linear and circular CDKN2B-AS1 expression is associated with Inflammatory Bowel Disease and participates in intestinal barrier formation.			hsa_circ_CDKN2B-AS1	CDKN2B-AS1	Inflammatory bowel disease 	MONDO:0005265	inflammatory bowel disease	down-regulated	RT-qPCR	"The circular form of CDKN2B-AS1 is down-regulated in UC-active/IBD colonic biopsies. Experimental knockdown (targeting both linear and circular transcripts) in Caco2 BBE cells increases proliferation and enhances epithelial barrier function, associated with reduced Claudin-2 levels, and the RNA is primarily nuclear."	0.7091
31207490	Molecular therapy. Nucleic acids	2019	Circular RNA Expression Profiling and the Potential Role of hsa_circ_0089172 in Hashimoto's Thyroiditis via Sponging miR125a-3p.	hsa_circ_0089172				Hashimoto¡¯s thyroiditis 	MONDO:0007699	Hashimoto thyroiditis	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0089172 is up-regulated in PBMCs from Hashimoto¡¯s thyroiditis patients and inversely correlates with miR-125a-3p. It likely acts as a miR-125a-3p sponge to modulate IL-23R expression and shows potential diagnostic value by ROC analysis.	0.5849
31207490	Molecular therapy. Nucleic acids	2019	Circular RNA Expression Profiling and the Potential Role of hsa_circ_0089172 in Hashimoto's Thyroiditis via Sponging miR125a-3p.	hsa_circ_0007777				Hashimoto¡¯s thyroiditis 	MONDO:0007699	Hashimoto thyroiditis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0007777 is significantly up-regulated in PBMCs from Hashimoto¡¯s thyroiditis patients versus healthy controls, as validated by RT-qPCR; no specific mechanism or clinical role was reported."	0.3588
31207490	Molecular therapy. Nucleic acids	2019	Circular RNA Expression Profiling and the Potential Role of hsa_circ_0089172 in Hashimoto's Thyroiditis via Sponging miR125a-3p.	hsa_circ_0012152				Hashimoto¡¯s thyroiditis 	MONDO:0007699	Hashimoto thyroiditis	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0012152 is up-regulated in PBMCs from Hashimoto¡¯s thyroiditis patients and was validated by RT-qPCR. It also shows potential diagnostic value for HT based on ROC curve analysis (AUC 0.702).	0.4679
31207490	Molecular therapy. Nucleic acids	2019	Circular RNA Expression Profiling and the Potential Role of hsa_circ_0089172 in Hashimoto's Thyroiditis via Sponging miR125a-3p.	hsa_circ_0000075				Hashimoto¡¯s thyroiditis 	MONDO:0007699	Hashimoto thyroiditis	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0000075 is up-regulated in PBMCs from Hashimoto¡¯s thyroiditis patients and was validated by RT-qPCR. It shows diagnostic potential for HT by ROC analysis (AUC 0.715).	0.4679
31213578	Bioscience reports	2019	Integrated analysis of a competing endogenous RNA network in renal cell carcinoma using bioinformatics tools.	hsa_circ_0031594		hsa_circ_EGLN3	EGLN3	renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	up-regulated	RNA-seq; Microarray	hsa_circ_0031594 (host gene EGLN3) was identified as an up-regulated differentially expressed circRNA in RCC and included as a node in a predicted circRNA_miRNA_mRNA ceRNA network constructed from GEO and TCGA datasets. No wet-lab functional/mechanistic validation was reported for this circRNA in the study.	0.2465
31213578	Bioscience reports	2019	Integrated analysis of a competing endogenous RNA network in renal cell carcinoma using bioinformatics tools.	hsa_circ_0029340		hsa_circ_SCARB1	SCARB1	renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	up-regulated	RNA-seq; Microarray	"hsa_circ_0029340 (host gene SCARB1) was identified as an up-regulated differentially expressed circRNA in RCC and included in a predicted circRNA_miRNA_mRNA ceRNA network derived from GEO and TCGA datasets, without experimental validation."	0.2465
31213578	Bioscience reports	2019	Integrated analysis of a competing endogenous RNA network in renal cell carcinoma using bioinformatics tools.	hsa_circ_0039238		hsa_circ_NETO2	NETO2	renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	up-regulated	RNA-seq; Microarray	hsa_circ_0039238 (host gene NETO2) was found up-regulated in RCC and included in a bioinformatically constructed ceRNA network; no direct functional experiments were reported for this circRNA.	0.2465
31213578	Bioscience reports	2019	Integrated analysis of a competing endogenous RNA network in renal cell carcinoma using bioinformatics tools.	hsa_circ_0084927		hsa_circ_ESRP1	ESRP1	renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	down-regulated	RNA-seq; Microarray	hsa_circ_0084927 (host gene ESRP1) was identified as a down-regulated circRNA in RCC and incorporated into a predicted ceRNA network built from GEO/TCGA data; no experimental validation was presented.	0.2465
31213578	Bioscience reports	2019	Integrated analysis of a competing endogenous RNA network in renal cell carcinoma using bioinformatics tools.	hsa_circ_0035442		hsa_circ_ALDH1A2	ALDH1A2	renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	down-regulated	RNA-seq; Microarray	"hsa_circ_0035442 (host gene ALDH1A2) was identified as down-regulated in RCC and used as a node in a predicted ceRNA network constructed from public datasets, without experimental validation."	0.2465
31213578	Bioscience reports	2019	Integrated analysis of a competing endogenous RNA network in renal cell carcinoma using bioinformatics tools.	hsa_circ_0025135		hsa_circ_SCNN1A	SCNN1A	renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	down-regulated	RNA-seq; Microarray	hsa_circ_0025135 (host gene SCNN1A) was identified as down-regulated in RCC and included in a predicted ceRNA network based on public expression datasets; no experimental validation was reported.	0.2465
31213827	OncoTargets and therapy	2019	Circular RNA hsa_circ_009755 downregulation correlates with clinicopathology in oral squamous cell carcinoma.		hsa_circ_009755	hsa_circ_IBTK	IBTK	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR; RNA-seq; Microarray	"hsa_circ_009755 is down-regulated in OSCC tissues and OSCC cell lines and its low expression is associated with T stage. It shows diagnostic potential for OSCC (AUC 0.782) and is predicted to interact with miR-585-5p, miR-29a-5p, and miR-6079, although downstream targets were not experimentally validated."	0.5267
31213828	OncoTargets and therapy	2019	circANKS1B regulates FOXM1 expression and promotes cell migration and invasion by functioning as a sponge of the miR-149 in colorectal cancer.	hsa_circ_0007294		hsa_circ_ANKS1B	ANKS1B	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circANKS1B is up-regulated in colorectal cancer tissues and cell lines and promotes CRC cell migration and invasion. Mechanistically, it functions as a miR-149 sponge to increase FOXM1 expression and elevate FOXM1/Slug levels, thereby enhancing metastatic phenotypes."	0.7129
31214170	Frontiers in immunology	2019	Cecal CircRNAs Are Associated With the Response to Salmonella Enterica Serovar Enteritidis Inoculation in the Chicken.		NC_006091.4: 65510578|65515090	gga_circ_CLOCK	CLOCK	Salmonella enterica serovar Enteritidis (SE) inoculation 	MONDO:0000827	salmonellosis	up-regulated	RNA-seq	This circRNA (from host gene CLOCK) is significantly up-regulated in chicken cecum after SE inoculation and is implicated in circadian rhythm-related response to infection.	0.31
31214170	Frontiers in immunology	2019	Cecal CircRNAs Are Associated With the Response to Salmonella Enterica Serovar Enteritidis Inoculation in the Chicken.		NC_006099.4: 16132825|16236906	gga_circ_FOXP1	FOXP1	Salmonella enterica serovar Enteritidis (SE) inoculation 	MONDO:0000827	salmonellosis	dysregulated	RNA-seq	"This FOXP1-derived circRNA is significantly altered after SE inoculation, but its direction is only stated as opposite to another FOXP1 circRNA. The study suggests it may regulate SE-response through interactions with miRNAs/FOXP1-related regulation."	0.31
31214170	Frontiers in immunology	2019	Cecal CircRNAs Are Associated With the Response to Salmonella Enterica Serovar Enteritidis Inoculation in the Chicken.		NC_006099.4: 15993284|16006290	gga_circ_FOXP1	FOXP1	Salmonella enterica serovar Enteritidis (SE) inoculation 	MONDO:0000827	salmonellosis	dysregulated	RNA-seq	"This FOXP1-derived circRNA is significantly altered after SE inoculation, with an expression direction opposite to another FOXP1 circRNA. The paper proposes it may modulate SE-response through FOXP1/miRNA-related regulation, but details are not experimentally resolved."	0.31
31214170	Frontiers in immunology	2019	Cecal CircRNAs Are Associated With the Response to Salmonella Enterica Serovar Enteritidis Inoculation in the Chicken.		NC_006113.4:2670958|2679178			Salmonella enterica serovar Enteritidis (SE) inoculation	MONDO:0000827	salmonellosis	up-regulated	RT-qPCR; RNA-seq	NC_006113.4:2670958|2679178 is up-regulated in chicken cecum after SE inoculation and was experimentally validated by RT-qPCR (consistent with sequencing). No specific downstream mechanism was provided for this circRNA.	0.5618
31214170	Frontiers in immunology	2019	Cecal CircRNAs Are Associated With the Response to Salmonella Enterica Serovar Enteritidis Inoculation in the Chicken.		NC_006096.4:10814512|10838667			Salmonella enterica serovar Enteritidis (SE) inoculation	MONDO:0000827	salmonellosis	up-regulated	RT-qPCR; RNA-seq	NC_006096.4:10814512|10838667 is up-regulated in chicken cecum after SE inoculation and was validated by RT-qPCR with consistent direction versus sequencing. No mechanism was reported for this circRNA.	0.5618
31214170	Frontiers in immunology	2019	Cecal CircRNAs Are Associated With the Response to Salmonella Enterica Serovar Enteritidis Inoculation in the Chicken.		NC_006115.4:3194855|3195107			Salmonella enterica serovar Enteritidis (SE) inoculation	MONDO:0000827	salmonellosis	down-regulated	RT-qPCR; RNA-seq	NC_006115.4:3194855|3195107 is down-regulated in chicken cecum after SE inoculation and was validated by RT-qPCR with consistent direction versus sequencing. No downstream mechanism was reported for this circRNA.	0.5618
31219565	Database : the journal of biological databases and curation	2019	CCRDB: a cancer circRNAs-related database and its application in hepatocellular carcinoma-related circRNAs.	hsa_circ_0002130	Chr19:6702138|6702590	hsa_circ_C3	C3	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RNA-seq	hsa_circ_0002130 is down-regulated in HCC versus adjacent normal samples across multiple patient comparison groups and is proposed as a potential HCC biomarker candidate.	0.1768
31219565	Database : the journal of biological databases and curation	2019	CCRDB: a cancer circRNAs-related database and its application in hepatocellular carcinoma-related circRNAs.	hsa_circ_0084615	Chr8:62593527|62596747	hsa_circ_ASPH	ASPH	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RNA-seq	hsa_circ_0084615 is up-regulated in HCC versus adjacent normal samples in multiple patient comparison groups and is proposed as a potential HCC biomarker candidate.	0.1768
31219565	Database : the journal of biological databases and curation	2019	CCRDB: a cancer circRNAs-related database and its application in hepatocellular carcinoma-related circRNAs.	hsa_circ_0001445	Chr4:144464662|144465125	hsa_circ_SMARCA5	SMARCA5	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RNA-seq	hsa_circ_0001445 is down-regulated in HCC versus adjacent normal samples in multiple patient comparison groups and is proposed as a potential HCC biomarker candidate.	0.1768
31219565	Database : the journal of biological databases and curation	2019	CCRDB: a cancer circRNAs-related database and its application in hepatocellular carcinoma-related circRNAs.	hsa_circ_0001727	Chr7:99621042|99621930	hsa_circ_ZKSCAN1	ZKSCAN1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RNA-seq	hsa_circ_0001727 is down-regulated in HCC versus adjacent normal samples in multiple patient comparison groups and is proposed as a potential HCC biomarker candidate.	0.1768
31219565	Database : the journal of biological databases and curation	2019	CCRDB: a cancer circRNAs-related database and its application in hepatocellular carcinoma-related circRNAs.	hsa_circ_0001361	Chr3:171830242|171851336	hsa_circ_FNDC3B	FNDC3B	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RNA-seq	hsa_circ_0001361 is up-regulated in HCC versus adjacent normal samples in multiple patient comparison groups and is proposed as a potential HCC biomarker candidate.	0.1768
31219565	Database : the journal of biological databases and curation	2019	CCRDB: a cancer circRNAs-related database and its application in hepatocellular carcinoma-related circRNAs.		chr12:23998917|24048958	hsa_circ_SOX5	SOX5	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RNA-seq	A newly identified circRNA at chr12:23998917-24048958 (host gene SOX5) is down-regulated in HCC and proposed as a potential biomarker candidate based on sequencing/comparative analysis across patients.	0.1768
31219565	Database : the journal of biological databases and curation	2019	CCRDB: a cancer circRNAs-related database and its application in hepatocellular carcinoma-related circRNAs.		chr16:72090429|72093087	hsa_circ_HP	HP	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RNA-seq	A newly identified circRNA at chr16:72090429-72093087 (host gene HP) is down-regulated in HCC and proposed as a potential biomarker candidate based on sequencing/comparative analysis across patients.	0.1768
31228937	Molecular cancer	2019	Circular RNA circSLC8A1 acts as a sponge of miR-130b/miR-494 in suppressing bladder cancer progression via regulating PTEN.	hsa_circ_0000994	circSLC8A1	hsa_circ_SLC8A1	SLC8A1	bladder cancer	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"In bladder cancer, circSLC8A1 is down-regulated and functions as a tumor suppressor. It sponges miR-130b and miR-494 to de-repress PTEN, thereby inhibiting PI3K/Akt-related signaling and reducing proliferation, migration, invasion, and xenograft growth."	0.8634
31234008	Molecular therapy. Nucleic acids	2019	Non-coding RNA-Associated ceRNA Networks in a New Contrast-Induced Acute Kidney Injury Rat Model.		novel_circ_0004153			contrast-induced acute kidney injury 	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR; RNA-seq	"In a CI-AKI Sprague-Dawley rat model, novel_circ_0004153 is up-regulated in kidney and is proposed/validated as a ceRNA for rno-miR-144-3p, thereby associated with regulation of Naglu or Gpnmb expression in CI-AKI."	0.3858
31235426	EBioMedicine	2019	The RNA-binding protein RBM3 promotes cell proliferation in hepatocellular carcinoma by regulating circular RNA SCD-circRNA 2 production.		circ_novel_4982	hsa_circ_SCD	SCD	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Northern Blot; RNA-seq	"SCD-circRNA 2 is up-regulated in HCC tissues and its high expression predicts worse RFS/OS. Functionally, it is required for RBM3-driven proliferation and cell-cycle progression, and it promotes ERK phosphorylation downstream of RBM3."	0.8618
31243884	Thoracic cancer	2019	CircAGFG1 sponges miR-203 to promote EMT and metastasis of non-small-cell lung cancer by upregulating ZNF281 expression.		circAGFG1	hsa_circ_AGFG1	AGFG1	non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circAGFG1 is up-regulated in NSCLC tissues and promotes proliferation, invasion, migration, and EMT. It functions as a ceRNA by sponging miR-203, thereby increasing ZNF281 expression and facilitating NSCLC growth and metastasis."	0.7244
31249590	Frontiers in genetics	2019	"The Integrative Regulatory Network of circRNA, microRNA, and mRNA in Atrial Fibrillation."		hsa_circRNA_100612			Atrial fibrillation 	MONDO:0004981	atrial fibrillation	down-regulated	Microarray	"circRNA_100612 is down-regulated in AF atrial tissue and is proposed to participate in AF through interacting with miR-133b, potentially influencing miR-133b target genes such as KCNIP1, JPH2, and ADRB1."	0.1768
31249590	Frontiers in genetics	2019	"The Integrative Regulatory Network of circRNA, microRNA, and mRNA in Atrial Fibrillation."		hsa_circRNA_405917			Atrial fibrillation 	MONDO:0004981	atrial fibrillation	down-regulated	Microarray	"hsa/has_circRNA_405917 is down-regulated in AF atrial tissue and is included in a predicted regulatory network through interaction with hsa-miR-892a (and discussed with miR-892b), potentially affecting targets such as GJA1."	0.1768
31249590	Frontiers in genetics	2019	"The Integrative Regulatory Network of circRNA, microRNA, and mRNA in Atrial Fibrillation."		hsa_circRNA_008132			Atrial fibrillation 	MONDO:0004981	atrial fibrillation	up-regulated	Microarray	"hsa_circRNA_008132 is up-regulated in AF atrial tissue and is highlighted in a predicted AF-related interaction module through binding hsa-miR-892a, with downstream effects discussed in relation to miR-892b targets such as GJA1."	0.1768
31249590	Frontiers in genetics	2019	"The Integrative Regulatory Network of circRNA, microRNA, and mRNA in Atrial Fibrillation."		hsa_circRNA_104052			Atrial fibrillation 	MONDO:0004981	atrial fibrillation	up-regulated	Microarray	"hsa_circRNA_104052 is up-regulated in AF atrial tissue and is highlighted as an AF-related circRNA due to predicted interaction with hsa-miR-892a, within a network discussed around miR-892b and its target GJA1."	0.1768
31249590	Frontiers in genetics	2019	"The Integrative Regulatory Network of circRNA, microRNA, and mRNA in Atrial Fibrillation."		hsa_circRNA_101021			Atrial fibrillation 	MONDO:0004981	atrial fibrillation	up-regulated	Microarray	"hsa_circRNA_101021 is up-regulated in AF atrial tissue and is highlighted in the predicted AF regulatory network via interaction with hsa-miR-892a, discussed alongside miR-892b and its target GJA1."	0.1768
31249590	Frontiers in genetics	2019	"The Integrative Regulatory Network of circRNA, microRNA, and mRNA in Atrial Fibrillation."		hsa_circRNA_101020			Atrial fibrillation 	MONDO:0004981	atrial fibrillation	up-regulated	Microarray	"hsa_circRNA_101020 is up-regulated in AF atrial tissue and is highlighted as potentially AF-related due to predicted interaction with hsa-miR-892a, within a network discussed around miR-892b and its target GJA1."	0.1768
31249590	Frontiers in genetics	2019	"The Integrative Regulatory Network of circRNA, microRNA, and mRNA in Atrial Fibrillation."		hsa_circRNA_102341			Atrial fibrillation 	MONDO:0004981	atrial fibrillation	up-regulated	Microarray	"hsa_circRNA_102341 is up-regulated in AF atrial tissue and is highlighted in a predicted interaction module involving hsa-miR-892a (discussed with miR-892b), potentially linked to downstream target GJA1."	0.1768
31249590	Frontiers in genetics	2019	"The Integrative Regulatory Network of circRNA, microRNA, and mRNA in Atrial Fibrillation."		hsa_circRNA_404737			Atrial fibrillation 	MONDO:0004981	atrial fibrillation	up-regulated	Microarray	hsa_circRNA_404737 is up-regulated in AF atrial tissue and is highlighted due to predicted binding with AF-related miRNAs hsa-miR-3171 and hsa-miR-3149 as part of an inferred circRNA_miRNA_mRNA network.	0.1768
31249590	Frontiers in genetics	2019	"The Integrative Regulatory Network of circRNA, microRNA, and mRNA in Atrial Fibrillation."		hsa_circRNA_002641			Atrial fibrillation 	MONDO:0004981	atrial fibrillation	up-regulated	Microarray	hsa_circRNA_002641 is up-regulated in AF atrial tissue and is highlighted due to predicted binding with AF-related miRNAs hsa-miR-3171 and hsa-miR-3149 in the constructed regulatory network.	0.1768
31249590	Frontiers in genetics	2019	"The Integrative Regulatory Network of circRNA, microRNA, and mRNA in Atrial Fibrillation."		hsa_circRNA_079477			Atrial fibrillation 	MONDO:0004981	atrial fibrillation	up-regulated	Microarray	hsa_circRNA_079477 is up-regulated in AF atrial tissue and is included among AF-associated circRNAs based on predicted interaction with hsa-miR-3149.	0.1768
31249811	Frontiers in oncology	2019	Hsa_circ_0001946 Inhibits Lung Cancer Progression and Mediates Cisplatin Sensitivity in Non-small Cell Lung Cancer via the Nucleotide Excision Repair Signaling Pathway.	hsa_circ_0001946		hsa_circ_CDR1	CDR1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001946 is down-regulated in NSCLC tissues and acts as a tumor suppressor in A549 cells. Its knockdown promotes proliferation/migration/invasion, reduces apoptosis, and increases cisplatin resistance by activating the NER pathway, potentially via a ceRNA mechanism involving miR-7-5p, miR-671-5p, miR-1270 and miR-3156-5p."	0.8355
31251793	PloS one	2019	Expression profiles of circRNAs and the potential diagnostic value of serum circMARK3 in human acute Stanford type A aortic dissection.		circMARK3	hsa_circ_MARK3	MARK3	acute Stanford type A aortic dissection 	MONDO:0022470	aortic dissection lentiginosis	up-regulated	RT-qPCR; RNA-seq	"circMARK3 is up-regulated in AAAD aortic tissues and in patient serum. The study predicts a circMARK3_hsa-miR-1273g-3p_Fgr regulatory axis, supported by circMARK3 overexpression in HASMCs reducing miR-1273g-3p and increasing Fgr protein. Serum circMARK3 shows strong diagnostic performance for AAAD by ROC analysis."	0.7039
31251793	PloS one	2019	Expression profiles of circRNAs and the potential diagnostic value of serum circMARK3 in human acute Stanford type A aortic dissection.		circUBA2	hsa_circ_UBA2	UBA2	acute Stanford type A aortic dissection 	MONDO:0022470	aortic dissection lentiginosis	up-regulated	RT-qPCR	circUBA2 is experimentally validated by RT-qPCR as up-regulated in AAAD aortic tissues compared with matched controls.	0.2995
31251793	PloS one	2019	Expression profiles of circRNAs and the potential diagnostic value of serum circMARK3 in human acute Stanford type A aortic dissection.		circARHGAP26	hsa_circ_ARHGAP26	ARHGAP26	acute Stanford type A aortic dissection 	MONDO:0022470	aortic dissection lentiginosis	up-regulated	RT-qPCR	circARHGAP26 is experimentally validated by RT-qPCR as up-regulated in AAAD aortic tissues compared with matched controls.	0.2995
31251793	PloS one	2019	Expression profiles of circRNAs and the potential diagnostic value of serum circMARK3 in human acute Stanford type A aortic dissection.		circCHSY1	hsa_circ_CHSY1	CHSY1	acute Stanford type A aortic dissection 	MONDO:0022470	aortic dissection lentiginosis	up-regulated	RT-qPCR	circCHSY1 is experimentally validated by RT-qPCR as up-regulated in AAAD aortic tissues compared with matched controls.	0.2995
31251793	PloS one	2019	Expression profiles of circRNAs and the potential diagnostic value of serum circMARK3 in human acute Stanford type A aortic dissection.		circMBNL1	hsa_circ_MBNL1	MBNL1	acute Stanford type A aortic dissection 	MONDO:0022470	aortic dissection lentiginosis	up-regulated	RT-qPCR	circMBNL1 is experimentally validated by RT-qPCR as up-regulated in AAAD aortic tissues compared with matched controls.	0.2995
31251793	PloS one	2019	Expression profiles of circRNAs and the potential diagnostic value of serum circMARK3 in human acute Stanford type A aortic dissection.		circIQGAP1	hsa_circ_IQGAP1	IQGAP1	acute Stanford type A aortic dissection 	MONDO:0022470	aortic dissection lentiginosis	up-regulated	RT-qPCR	circIQGAP1 is experimentally validated by RT-qPCR as up-regulated in AAAD aortic tissues compared with matched controls.	0.2995
31251793	PloS one	2019	Expression profiles of circRNAs and the potential diagnostic value of serum circMARK3 in human acute Stanford type A aortic dissection.		circMED13	hsa_circ_MED13	MED13	acute Stanford type A aortic dissection 	MONDO:0022470	aortic dissection lentiginosis	up-regulated	RT-qPCR	circMED13 is experimentally validated by RT-qPCR as up-regulated in AAAD aortic tissues compared with matched controls.	0.2995
31251793	PloS one	2019	Expression profiles of circRNAs and the potential diagnostic value of serum circMARK3 in human acute Stanford type A aortic dissection.		circMYH10	hsa_circ_MYH10	MYH10	acute Stanford type A aortic dissection 	MONDO:0022470	aortic dissection lentiginosis	up-regulated	RT-qPCR	circMYH10 is experimentally validated by RT-qPCR as up-regulated in AAAD aortic tissues compared with matched controls.	0.2995
31251793	PloS one	2019	Expression profiles of circRNAs and the potential diagnostic value of serum circMARK3 in human acute Stanford type A aortic dissection.		circRAB7A	hsa_circ_RAB7A	RAB7A	acute Stanford type A aortic dissection 	MONDO:0022470	aortic dissection lentiginosis	up-regulated	RT-qPCR	circRAB7A is experimentally validated by RT-qPCR as up-regulated in AAAD aortic tissues compared with matched controls.	0.2995
31251793	PloS one	2019	Expression profiles of circRNAs and the potential diagnostic value of serum circMARK3 in human acute Stanford type A aortic dissection.		circCEP70	hsa_circ_CEP70	CEP70	acute Stanford type A aortic dissection 	MONDO:0022470	aortic dissection lentiginosis	down-regulated	RT-qPCR	circCEP70 is experimentally validated by RT-qPCR as down-regulated in AAAD aortic tissues compared with matched controls.	0.2995
31251793	PloS one	2019	Expression profiles of circRNAs and the potential diagnostic value of serum circMARK3 in human acute Stanford type A aortic dissection.		circFAM120B	hsa_circ_FAM120B	FAM120B	acute Stanford type A aortic dissection 	MONDO:0022470	aortic dissection lentiginosis	down-regulated	RT-qPCR	circFAM120B is experimentally validated by RT-qPCR as down-regulated in AAAD aortic tissues compared with matched controls.	0.2995
31254341	Medical science monitor : international medical journal of experimental and clinical research	2019	High-Throughput Data Reveals Novel Circular RNAs via Competitive Endogenous RNA Networks Associated with Human Intracranial Aneurysms.	hsa_circ_0072309		hsa_circ_LIFR	LIFR	intracranial aneurysm 	MONDO:0005291	brain aneurysm	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0072309 is down-regulated in intracranial aneurysm tissues and also shows consistent down-regulation in peripheral blood. It likely acts as a ceRNA by sponging hsa-miR-519e-5p and hsa-miR-516b-5p to regulate DDR2 and SAT2, implicating smooth muscle cell dysfunction and vascular injury, and it shows diagnostic potential by ROC analysis."	0.5963
31254341	Medical science monitor : international medical journal of experimental and clinical research	2019	High-Throughput Data Reveals Novel Circular RNAs via Competitive Endogenous RNA Networks Associated with Human Intracranial Aneurysms.	hsa_circ_0008433		hsa_circ_PDE4B	PDE4B	intracranial aneurysm 	MONDO:0005291	brain aneurysm	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0008433 is up-regulated in intracranial aneurysm tissues and is implicated in vascular injury by regulating MMP2 through a ceRNA mechanism (sponging hsa-miR-181c-5p and hsa-miR-181b-5p). It is differentially expressed in peripheral blood and shows diagnostic potential by ROC analysis.	0.5963
31256433	Journal of cellular physiology	2020	"hsa_circ_0000745 promotes cervical cancer by increasing cell proliferation, migration, and invasion."	hsa_circ_0000745		hsa_circ_SPECC1	SPECC1	uterine cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000745 (circ-0745), derived from SPECC1, is up-regulated in cervical cancer/SCC tissues and promotes proliferation, migration, invasion and tumor growth. Mechanistically, circ-0745 represses E-cadherin, and its knockdown increases E-cadherin and reduces malignant phenotypes. Higher expression associates with poor differentiation and vascular/lymphatic invasion, suggesting prognostic relevance."	0.5802
31257675	Journal of clinical laboratory analysis	2019	"The role of circular RNA HECTD1 expression in disease risk, disease severity, inflammation, and recurrence of acute ischemic stroke."			hsa_circ_HECTD1	HECTD1	acute ischemic stroke 	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR	"In PBMCs from acute ischemic stroke patients, circRNA HECTD1 is up-regulated versus controls and correlates with NIHSS score and pro-inflammatory markers. Higher circRNA HECTD1 is associated with increased recurrence risk and shorter recurrence-free survival, supporting its potential as a clinical biomarker in AIS."	0.5802
31261517	Medicine	2019	Circular RNA expression profile in peripheral blood mononuclear cells from Crohn disease patients.		hsa_circRNA_092520			Crohn disease 	MONDO:0005011	Crohn disease	up-regulated	RT-qPCR; Microarray	CircRNA 092520 is significantly up-regulated in PBMCs from Crohn disease patients versus healthy controls and shows diagnostic value by ROC analysis (AUC 0.66).	0.5047
31261517	Medicine	2019	Circular RNA expression profile in peripheral blood mononuclear cells from Crohn disease patients.		hsa_circRNA_102610			Crohn disease 	MONDO:0005011	Crohn disease	up-regulated	RT-qPCR; Microarray	CircRNA 102610 is significantly up-regulated in PBMCs from Crohn disease patients versus healthy controls and has diagnostic value by ROC analysis (AUC 0.78).	0.5047
31261517	Medicine	2019	Circular RNA expression profile in peripheral blood mononuclear cells from Crohn disease patients.		hsa_circRNA_004662	hsa_circ_SOD2	SOD2	Crohn disease 	MONDO:0005011	Crohn disease	up-regulated	RT-qPCR; Microarray	"CircRNA_004662 (circ_004662) is up-regulated in PBMCs from Crohn disease patients and shows good diagnostic performance (AUC 0.85). It is higher in CD than in UC and is proposed to function via a predicted ceRNA network by sponging several miRNAs, potentially linking to the mTOR pathway (prediction only)."	0.5047
31261517	Medicine	2019	Circular RNA expression profile in peripheral blood mononuclear cells from Crohn disease patients.		hsa_circRNA_103124			Crohn disease 	MONDO:0005011	Crohn disease	up-regulated	RT-qPCR; Microarray	CircRNA 103124 is significantly up-regulated in PBMCs from Crohn disease patients versus healthy controls and has diagnostic value by ROC analysis (AUC 0.74).	0.5047
31261542	Medicine	2019	Differential circular RNA expression profiles of invasive and non-invasive non-functioning pituitary adenomas: A microarray analysis.		hsa_circRNA_405761			non-functioning pituitary adenomas 	MONDO:0019613	non-functioning pituitary adenoma	up-regulated	RT-qPCR; Microarray	hsa_circRNA_405761 is significantly up-regulated in invasive versus non-invasive NFPAs based on microarray discovery and RT-qPCR validation in clinical tumor tissues.	0.4032
31261542	Medicine	2019	Differential circular RNA expression profiles of invasive and non-invasive non-functioning pituitary adenomas: A microarray analysis.		hsa_circRNA_000992			non-functioning pituitary adenomas 	MONDO:0019613	non-functioning pituitary adenoma	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_000992 is significantly up-regulated in invasive versus non-invasive NFPAs, supported by microarray profiling and RT-qPCR validation in patient tumor tissues."	0.4032
31261542	Medicine	2019	Differential circular RNA expression profiles of invasive and non-invasive non-functioning pituitary adenomas: A microarray analysis.		hsa_circRNA_102598			non-functioning pituitary adenomas 	MONDO:0019613	non-functioning pituitary adenoma	down-regulated	RT-qPCR; Microarray	hsa_circRNA_102598 is significantly down-regulated in invasive versus non-invasive NFPAs based on microarray profiling and RT-qPCR validation in patient tumor tissues.	0.4032
31261542	Medicine	2019	Differential circular RNA expression profiles of invasive and non-invasive non-functioning pituitary adenomas: A microarray analysis.		hsa_circRNA_102597			non-functioning pituitary adenomas 	MONDO:0019613	non-functioning pituitary adenoma	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_102597 is down-regulated in invasive versus non-invasive NFPAs and shows diagnostic/prognostic utility (alone or combined with Ki-67) for invasiveness and postoperative progression/recurrence. The paper proposes it may act through a predicted circRNA-miRNA-gene (ceRNA-like) network, but specific miRNA/mRNA effectors are not experimentally validated here."	0.6841
31269941	BMC complementary and alternative medicine	2019	Qianggan extract improved nonalcoholic steatohepatitis by modulating lncRNA/circRNA immune ceRNA networks.	mmu_circ_0004572	circ_0004572			non-alcoholic steatohepatitis 	MONDO:0007027	metabolic dysfunction-associated steatohepatitis	up-regulated	RT-qPCR; Microarray	circ_0004572 is up-regulated in MCD diet-induced NASH mouse liver and reduced after Qianggan extract treatment. It is proposed to function as a ceRNA by binding 2 miRNAs and thereby regulating 32 immune-related target mRNAs implicated in NASH immune processes.	0.4997
31269941	BMC complementary and alternative medicine	2019	Qianggan extract improved nonalcoholic steatohepatitis by modulating lncRNA/circRNA immune ceRNA networks.	mmu_circ_0009453	circ_0009453			non-alcoholic steatohepatitis 	MONDO:0007027	metabolic dysfunction-associated steatohepatitis	up-regulated	RT-qPCR; Microarray	circ_0009453 is up-regulated in MCD-induced NASH mouse liver and is reduced by Qianggan extract. It is predicted to act as a ceRNA interacting with four miRNAs to modulate 54 immune-related mRNAs.	0.4997
31269941	BMC complementary and alternative medicine	2019	Qianggan extract improved nonalcoholic steatohepatitis by modulating lncRNA/circRNA immune ceRNA networks.	mmu_circ_0009212	circ_0009212			non-alcoholic steatohepatitis 	MONDO:0007027	metabolic dysfunction-associated steatohepatitis	up-regulated	RT-qPCR; Microarray	circ_0009212 is up-regulated in MCD-induced NASH mouse liver and decreased after Qianggan extract treatment. It is predicted to act as a ceRNA (including a reported association with miR-296-5p) to regulate immune-related mRNAs.	0.4997
31269941	BMC complementary and alternative medicine	2019	Qianggan extract improved nonalcoholic steatohepatitis by modulating lncRNA/circRNA immune ceRNA networks.	mmu_circ_0009029	circ_0009029			non-alcoholic steatohepatitis 	MONDO:0007027	metabolic dysfunction-associated steatohepatitis	up-regulated	Microarray	circ_0009029 is up-regulated in MCD-induced NASH mouse liver and reduced after Qianggan extract treatment. It is predicted to sponge miR-362-5p and thereby regulate 24 immune-related mRNAs within an immune ceRNA network.	0.4535
31270953	Journal of cellular and molecular medicine	2019	Circular RNA circABCC4 as the ceRNA of miR-1182 facilitates prostate cancer progression by promoting FOXP4 expression.	hsa_circ_0030586	circABCC4	hsa_circ_ABCC4	ABCC4	prostate cancer	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	"circABCC4 is up-regulated in prostate cancer and acts as an oncogenic circRNA. It functions as a ceRNA by sponging miR-1182, thereby relieving repression of FOXP4 and promoting proliferation, cell-cycle progression, migration, invasion, and xenograft tumor growth. High circABCC4 expression is associated with shorter survival and more advanced/metastatic disease."	0.7373
31281495	Theranostics	2019	Circular RNAs negatively regulate cancer stem cells by physically binding FMRP against CCAR1 complex in hepatocellular carcinoma.	hsa_circ_0001727		hsa_circ_ZKSCAN1	ZKSCAN1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; ISH; RNA-seq	"circZKSCAN1 is down-regulated in HCC and acts as a tumor suppressor by inhibiting cancer stemness and other malignant phenotypes. Mechanistically it functions as an RBP sponge, competitively binding FMRP to prevent FMRP_CCAR1 mRNA association, thereby reducing CCAR1-driven Wnt/beta-catenin transcriptional activity; its reduction is linked to decreased QKI5."	0.8826
31293639	Journal of Cancer	2019	Circular RNA Signature in Hepatocellular Carcinoma.	hsa_circ_0001806		hsa_circ_CSPP1	CSPP1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circ_0001806 was identified as a differentially expressed circRNA in HCC tissues (microarray datasets) and its up-regulation was experimentally validated in HepG2 versus L02 cells by RT-qPCR with BSJ confirmation by Sanger sequencing. No specific downstream function or mechanism was experimentally established in this study.	0.5135
31293639	Journal of Cancer	2019	Circular RNA Signature in Hepatocellular Carcinoma.	hsa_circ_0003528		hsa_circ_SEC24A	SEC24A	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circ_0003528 was identified as up-regulated in HCC tissues (microarray datasets) and validated as up-regulated in HepG2 versus L02 by RT-qPCR with Sanger sequencing confirmation of the back-splice junction. The study provides only predicted miRNA interactions without functional validation.	0.5135
31293639	Journal of Cancer	2019	Circular RNA Signature in Hepatocellular Carcinoma.	hsa_circ_0008583		hsa_circ_DLG1	DLG1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circ_0008583 was found up-regulated in HCC datasets and validated as up-regulated in HepG2 versus L02 using RT-qPCR with BSJ Sanger sequencing. The study reports only predicted miRNA binding partners without experimental mechanistic validation.	0.5135
31293639	Journal of Cancer	2019	Circular RNA Signature in Hepatocellular Carcinoma.	hsa_circ_0009910		hsa_circ_MFN2	MFN2	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circ_0009910 was identified as an up-regulated circRNA in HCC by microarray and validated in HepG2 versus L02 using RT-qPCR with Sanger sequencing verification. The study does not experimentally define its mechanistic role in HCC.	0.5135
31293639	Journal of Cancer	2019	Circular RNA Signature in Hepatocellular Carcinoma.	hsa_circ_0032704		hsa_circ_TTLL5	TTLL5	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0032704 is up-regulated in HCC and validated in HepG2 vs L02. The paper suggests it may act as a miRNA sponge (predicted) for miR-203a, potentially promoting HCC progression by relieving repression of oncogenic targets."	0.5135
31293639	Journal of Cancer	2019	Circular RNA Signature in Hepatocellular Carcinoma.	hsa_circ_0065214		hsa_circ_SCAP	SCAP	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0065214 is up-regulated in HCC and validated in HepG2 vs L02. The paper suggests it may sponge miR-7 (prediction-based), potentially promoting HCC progression via derepression of oncogenic targets."	0.5135
31293639	Journal of Cancer	2019	Circular RNA Signature in Hepatocellular Carcinoma.	hsa_circ_0007762		hsa_circ_STXBP5	STXBP5	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	hsa_circ_0007762 was identified as a down-regulated circRNA in HCC datasets and validated as down-regulated in HepG2 versus L02 by RT-qPCR with Sanger sequencing confirmation of the back-splice junction. No specific functional mechanism was established.	0.5135
31296839	Cell death & disease	2019	KHDRBS3 regulates the permeability of blood-tumor barrier via cDENND4C/miR-577 axis.	hsa_circ_0005684		hsa_circ_DENND4C	DENND4C	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR	"cDENND4C is up-regulated in glioma-associated endothelial cells (GECs) and helps maintain BTB integrity by sustaining tight junction protein expression. Mechanistically, KHDRBS3 binds cDENND4C to increase its stability, and cDENND4C sponges miR-577 to relieve repression of ZO-1/occludin/claudin-1, thereby reducing BTB permeability and limiting doxorubicin penetration."	0.8107
31301086	Cancer science	2019	Circular RNA circCRIM1 inhibits invasion and metastasis in lung adenocarcinoma through the microRNA (miR)-182/miR-93-leukemia inhibitory factor receptor pathway.	hsa_circ_0002346		hsa_circ_CRIM1	CRIM1	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; ISH	"circCRIM1 is down-regulated in LUAC and suppresses LUAC cell migration, invasion, and metastasis. It predominantly localizes to the cytoplasm and acts as an Ago2-dependent miRNA sponge for miR-93 and miR-182, thereby relieving repression of LIFR. Clinically, low circCRIM1 associates with lymph node metastasis, higher TNM stage, and worse overall survival."	0.8932
31302495	Molecular therapy. Nucleic acids	2019	Targeting the circBMPR2/miR-553/USP4 Axis as a Potent Therapeutic Approach for Breast Cancer.	hsa_circ_0003218		hsa_circ_BMPR2	BMPR2	breast cancer	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; RNA-seq	"circBMPR2 is down-regulated in breast cancer (especially metastatic cases) and functions as a tumor suppressor by inhibiting proliferation, migration/invasion, EMT, and tamoxifen resistance. Mechanistically, it acts in the cytoplasm as a ceRNA sponge for miR-553 to de-repress USP4, thereby increasing TAM-induced apoptosis and reducing TAM resistance."	0.8635
31308756	Cancer management and research	2019	Analysis of the circular RNA transcriptome in the grade 3 endometrial cancer.	hsa_circ_0039569		hsa_circ_CCL22	CCL22	grade 3 endometrial cancer 	MONDO:0002447	endometrial carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0039569 is up-regulated in grade 3 endometrial cancer tissues versus adjacent non-cancerous endometrial tissues and was validated by qRT-PCR. Bioinformatics predicted it may act as a miRNA sponge for hsa-miR-542-3p and hsa-let-7c-5p, and its expression correlates with tumor differentiation."	0.4276
31308756	Cancer management and research	2019	Analysis of the circular RNA transcriptome in the grade 3 endometrial cancer.	hsa_circ_0001610		hsa_circ_TNFRSF21	TNFRSF21	grade 3 endometrial cancer 	MONDO:0002447	endometrial carcinoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0001610 is up-regulated in grade 3 endometrial cancer tissues versus adjacent non-cancerous endometrial tissues and was validated by qRT-PCR; it also shows higher expression in grade 3 EC than in grade 1_2 EC.	0.5129
31308756	Cancer management and research	2019	Analysis of the circular RNA transcriptome in the grade 3 endometrial cancer.	hsa_circ_0000437		hsa_circ_CORO1C	CORO1C	grade 3 endometrial cancer 	MONDO:0002447	endometrial carcinoma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0000437 is down-regulated in grade 3 endometrial cancer tissues versus adjacent non-cancerous endometrial tissues and was validated by qRT-PCR.	0.5129
31308756	Cancer management and research	2019	Analysis of the circular RNA transcriptome in the grade 3 endometrial cancer.	hsa_circ_0001776		hsa_circ_ESYT2	ESYT2	grade 3 endometrial cancer 	MONDO:0002447	endometrial carcinoma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0001776 is down-regulated in grade 3 endometrial cancer tissues versus adjacent non-cancerous endometrial tissues and was validated by qRT-qPCR.	0.5129
31308756	Cancer management and research	2019	Analysis of the circular RNA transcriptome in the grade 3 endometrial cancer.	hsa_circ_0009043		hsa_circ_EXOC6B	EXOC6B	grade 3 endometrial cancer 	MONDO:0002447	endometrial carcinoma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0009043 is down-regulated in grade 3 endometrial cancer tissues versus adjacent non-cancerous endometrial tissues and was validated by qRT-qPCR.	0.5129
31316543	Frontiers in genetics	2019	Upregulation of Circular RNA CircNFIB Attenuates Cardiac Fibrosis by Sponging miR-433.	mmu_circ_0011794		mmu_circ_Nfib	NFIB	cardiac fibrosis	MONDO:0005267	heart disorder	down-regulated	RT-qPCR	"In a mouse post-MI cardiac fibrosis model and TGF-beta-stimulated cardiac fibroblasts, circNFIB is down-regulated. circNFIB suppresses fibroblast proliferation by sponging miR-433, thereby restoring miR-433 target genes (AZIN1, JNK1) and dampening downstream ERK/p38/Smad3 signaling."	0.6908
31318114	Cell proliferation	2019	Elevated levels of hsa_circ_006100 in gastric cancer promote cell growth and metastasis via miR-195/GPRC5A signalling.		hsa_circ_006100			gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_006100 is up-regulated in gastric cancer tissues and cell lines and acts as an oncogenic circRNA. It inhibits miR-195 and thereby derepresses the miR-195 target GPRC5A (with involvement of EGFR signaling), promoting proliferation and migration/invasion and enhancing EMT-related changes; knockdown suppresses xenograft tumour growth."	0.7628
31324186	Molecular cancer	2019	Circular RNA circRHOT1 promotes hepatocellular carcinoma progression by initiation of NR2F6 expression.		hsa_circRNA_102034	hsa_circ_RHOT1	RHOT1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Northern Blot; ISH; Microarray	"circRHOT1 is up-regulated in HCC tissues and its high level is associated with poor prognosis. Functionally, it promotes HCC cell proliferation, migration/invasion, tumor growth and metastasis, partly by recruiting TIP60 to the NR2F6 promoter to activate NR2F6 transcription, with reported involvement of NOTCH2 signaling downstream."	0.8129
31324198	Journal of experimental & clinical cancer research : CR	2019	Hsa_circ_0058124 promotes papillary thyroid cancer tumorigenesis and invasiveness through the NOTCH3/GATAD2A axis.	hsa_circ_0058124		hsa_circ_FN1	FN1	papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0058124 is up-regulated in papillary thyroid cancer and correlates with unfavorable prognosis. It promotes proliferation and malignant behaviors by acting as a ceRNA (sponging miR-218-5p) to increase NUMB and thereby suppress the NOTCH3/GATAD2A axis, validated in vitro and in a xenograft model."	0.8442
31324812	Nature communications	2019	circTP63 functions as a ceRNA to promote lung squamous cell carcinoma progression by upregulating FOXM1.	hsa_circ_0068515	circTP63	hsa_circ_TP63	TP63	lung squamous cell carcinoma 	MONDO:0005097	squamous cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circTP63 (hsa_circ_0068515), derived from TP63, is up-regulated in LUSC and mainly localized in the cytoplasm. It promotes LUSC cell proliferation and tumor growth by sponging miR-873-3p to de-repress FOXM1, which increases CENPA/CENPB and accelerates cell-cycle progression."	0.8926
31328820	Journal of clinical laboratory analysis	2019	Clinical significances of hsa_circ_0067582 and hsa_circ_0005758 in gastric cancer tissues.	hsa_circ_0067582		hsa_circ_RASA2	RASA2	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	hsa_circ_0067582 (host gene RASA2) is significantly down-regulated in gastric cancer tissues and is associated with clinicopathological features (tissue CEA level and stage). It shows diagnostic potential for distinguishing GC tissues from controls by ROC analysis (AUC 0.671).	0.559
31328820	Journal of clinical laboratory analysis	2019	Clinical significances of hsa_circ_0067582 and hsa_circ_0005758 in gastric cancer tissues.	hsa_circ_0005758		hsa_circ_KIAA0907	KIAA0907	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	hsa_circ_0005758 (host gene KIAA0907) is significantly down-regulated in gastric cancer tissues and correlates with tissue CEA level and perineural invasion. It has diagnostic potential for distinguishing GC tissues from controls by ROC analysis (AUC 0.721).	0.559
31334580	Cell proliferation	2019	MicroRNA-191 promotes hepatocellular carcinoma cell proliferation by has_circ_0000204/miR-191/KLF6 axis.	hsa_circ_0000204				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	Microarray	"In HCC, hsa_circ_0000204 is downregulated (per circRNA microarray dataset) and functions as a sponge for miR-191. By binding and inactivating miR-191, it alleviates the miR-191-driven proliferative/cell-cycle phenotype, within the hsa_circ_0000204/miR-191/KLF6 regulatory network."	0.6157
31336316	Translational oncology	2019	Upregulated Circular RNA circ-UBE2D2 Predicts Poor Prognosis and Promotes Breast Cancer Progression by Sponging miR-1236 and miR-1287.		circ-UBE2D2	hsa_circ_UBE2D2	UBE2D2	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circ-UBE2D2 is up-regulated in breast cancer and promotes malignant phenotypes (proliferation, migration, invasion, tumor growth) while inhibiting apoptosis. It functions mainly as a ceRNA by sponging miR-1236 and miR-1287 to de-repress their downstream target genes, and high expression predicts poorer OS/DFS."	0.7451
31341180	Scientific reports	2019	Relationships of Non-coding RNA with diabetes and depression.		circRNA-TFRC	hsa_circ_TFRC	TFRC	T2DM with depression 	MONDO:0002050	depressive disorder	up-regulated	RNA-seq	circRNA-TFRC is up-regulated in peripheral blood of DD (T2DM with depression) patients versus T2DM alone and is suggested to relate to more severe insulin resistance/diabetic symptoms in DD. No specific downstream miRNA/target axis was experimentally established in this study.	0.1768
31341180	Scientific reports	2019	Relationships of Non-coding RNA with diabetes and depression.	hsa_circ_0002387	circRNA-TNIK	hsa_circ_TNIK	TNIK	T2DM with depression 	MONDO:0002050	depressive disorder	up-regulated	RNA-seq	hsa_circ_0002387 (circRNA-TNIK) is up-regulated in peripheral blood of DD patients versus T2DM and is discussed as being associated with depression-related mental disorders. The study did not experimentally define a downstream miRNA/target mechanism for this circRNA.	0.1768
31341219	Scientific reports	2019	Circular RNAs are differentially expressed in prostate cancer and are potentially associated with resistance to enzalutamide.	hsa_circ_0001721		hsa_circ_CDK14	CDK14	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001721 (host gene CDK14) is up-regulated in highly enzalutamide-resistant LNCaP clone 1 versus sensitive control cells. The study predicts miR-221 as a binding miRNA, but does not experimentally validate a downstream target or pathway."	0.3684
31341219	Scientific reports	2019	Circular RNAs are differentially expressed in prostate cancer and are potentially associated with resistance to enzalutamide.	hsa_circ_0004870		hsa_circ_RBM39	RBM39	prostate cancer 	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0004870 (host gene RBM39) is down-regulated in enzalutamide-resistant LNCaP clones and is also lower in malignant and AR-positive contexts in prostate-related cell lines. The study links its deregulation to drug resistance, potentially through RBM39/U2AF65 splicing-related biology and AR-V7 regulation, and predicts miR-145 binding."	0.3858
31346318	Cancer cell international	2019	Identification of circRNA-miRNA-mRNA regulatory network in gastric cancer by analysis of microarray data.	hsa_circ_0000788		hsa_circ_MSI2	MSI2	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	Microarray	hsa_circ_0000788 (MSI2-derived) was identified as an up-regulated DEcircRNA in gastric cancer and included as a node in the predicted circRNA_miRNA_mRNA ceRNA network constructed from public microarray/TCGA data; no specific miRNA/mRNA axis was reported for this circRNA.	0.1768
31346318	Cancer cell international	2019	Identification of circRNA-miRNA-mRNA regulatory network in gastric cancer by analysis of microarray data.	hsa_circ_0002019		hsa_circ_FOXRED1	FOXRED1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	Microarray	hsa_circ_0002019 (FOXRED1-derived) was up-regulated in gastric cancer and was included in a predicted ceRNA subnetwork module in which it may regulate the hub gene KIF23 via hsa-mir-1301.	0.1768
31346318	Cancer cell international	2019	Identification of circRNA-miRNA-mRNA regulatory network in gastric cancer by analysis of microarray data.	hsa_circ_0005699		hsa_circ_C16orf62	C16orf62	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	Microarray	hsa_circ_0005699 (C16orf62-derived) was down-regulated in gastric cancer and was predicted to participate in ceRNA modules targeting the hub genes MCM8 and NCAPD2 via hsa-mir-504.	0.1768
31346318	Cancer cell international	2019	Identification of circRNA-miRNA-mRNA regulatory network in gastric cancer by analysis of microarray data.	hsa_circ_0005777		hsa_circ_RGNEF	RGNEF	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	Microarray	"hsa_circ_0005777 (RGNEF-derived) was identified as a down-regulated DEcircRNA in gastric cancer and included in the predicted ceRNA network, but no specific downstream miRNA/mRNA axis was detailed for it."	0.1768
31346318	Cancer cell international	2019	Identification of circRNA-miRNA-mRNA regulatory network in gastric cancer by analysis of microarray data.	hsa_circ_0006896		hsa_circ_KIAA1429	KIAA1429	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	Microarray	hsa_circ_0006896 (KIAA1429-derived) was down-regulated in gastric cancer and was predicted to form a ceRNA axis regulating MCM4 via hsa-mir-373.	0.1768
31346318	Cancer cell international	2019	Identification of circRNA-miRNA-mRNA regulatory network in gastric cancer by analysis of microarray data.	hsa_circ_0007991		hsa_circ_EIF4G3	EIF4G3	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	Microarray	hsa_circ_0007991 (EIF4G3-derived) was down-regulated in gastric cancer and was predicted to regulate the hub gene MCM4 via hsa-mir-373 in the ceRNA subnetwork.	0.1768
31346318	Cancer cell international	2019	Identification of circRNA-miRNA-mRNA regulatory network in gastric cancer by analysis of microarray data.	hsa_circ_0067934		hsa_circ_PRKCI	PRKCI	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	Microarray	hsa_circ_0067934 (PRKCI-derived) was identified as a down-regulated DEcircRNA in gastric cancer and included in the predicted ceRNA network; no specific miRNA/mRNA axis was reported for it within GC in this study.	0.1768
31346335	Journal of oncology	2019	Circular RNA hsa_circ_0007142 Is Upregulated and Targets miR-103a-2-5p in Colorectal Cancer.	hsa_circ_0007142		hsa_circ_DOCK1	DOCK1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0007142 (derived from DOCK1) is up-regulated in colorectal cancer tissues and in CRC cell lines (HCT-116 and HT-29). It promotes malignant phenotypes (proliferation, migration, invasion) and directly targets miR-103a-2-5p, consistent with a miRNA-sponge/ceRNA-like mechanism; clinically, higher expression associates with poor differentiation and lymphatic metastasis."	0.7177
31354349	Cancer management and research	2019	CircRNA hsa_circ_0004585 as a potential biomarker for colorectal cancer.	hsa_circ_0004585		hsa_circ_KIAA1199	KIAA1199	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0004585 is up-regulated in CRC tissues and in patients¡¯ peripheral blood and shows diagnostic potential by ROC analysis. It is derived from KIAA1199 and is predicted (bioinformatically) to bind multiple miRNAs, but its downstream mechanism in CRC remains unclear."	0.5047
31357500	Cells	2019	Exposure to Ionizing Radiation Triggers Prolonged Changes in Circular RNA Abundance in the Embryonic Mouse Brain and Primary Neurons.		circ-0000604	mmu_circ_Pvt1	Pvt1	ionizing radiation exposure 	MONDO:0043458	radiation injury	up-regulated	RT-qPCR	"circ-0000604 is a Pvt1-derived circRNA validated by RT-qPCR and RNase R resistance assays. It is induced after ionizing radiation exposure with delayed kinetics and shows increased stability versus the linear transcript, supporting its potential as a longer-term radiation exposure biomarker."	0.5862
31357500	Cells	2019	Exposure to Ionizing Radiation Triggers Prolonged Changes in Circular RNA Abundance in the Embryonic Mouse Brain and Primary Neurons.		circ-0005724	mmu_circ_Pvt1	Pvt1	ionizing radiation exposure 	MONDO:0043458	radiation injury	up-regulated	RT-qPCR	"circ-0005724 is a Pvt1-derived circRNA validated as a circular, RNase R_resistant transcript and shown to be stable. It is upregulated after irradiation with prolonged kinetics and increases in blood 10 days post whole-body irradiation, supporting its candidacy as a long-term radiation exposure biomarker."	0.527
31357500	Cells	2019	Exposure to Ionizing Radiation Triggers Prolonged Changes in Circular RNA Abundance in the Embryonic Mouse Brain and Primary Neurons.		circ-0005721	mmu_circ_Pvt1	Pvt1	ionizing radiation exposure 	MONDO:0043458	radiation injury	unknown	RT-qPCR	circ-0005721 is a Pvt1-derived circRNA whose abundance increases during in vitro neuronal maturation in primary cortical neurons as measured by RT-qPCR. The study does not clearly report its radiation-induced change direction for this specific isoform in the provided text.	0.1155
31357500	Cells	2019	Exposure to Ionizing Radiation Triggers Prolonged Changes in Circular RNA Abundance in the Embryonic Mouse Brain and Primary Neurons.		circ-0009172	mmu_circ_Ano3	Ano3	ionizing radiation exposure 	MONDO:0043458	radiation injury	up-regulated	RT-qPCR	"circ-0009172 is an Ano3-derived circRNA validated by RT-qPCR and RNase R resistance assays, induced after irradiation with prolonged kinetics, and strongly increases with brain aging (reported up to ~220-fold), suggesting biomarker potential for brain age and radiation exposure history."	0.4844
31357500	Cells	2019	Exposure to Ionizing Radiation Triggers Prolonged Changes in Circular RNA Abundance in the Embryonic Mouse Brain and Primary Neurons.		circ-0009174	mmu_circ_Ano3	Ano3	ionizing radiation exposure 	MONDO:0043458	radiation injury	up-regulated	RT-qPCR	circ-0009174 (from Ano3) is a highly stable circRNA validated by RT-qPCR/RNase R approaches and induced after irradiation. Its increased abundance upon Actinomycin-D treatment suggests at least partly post-transcriptional biogenesis independent of ongoing transcription.	0.527
31357500	Cells	2019	Exposure to Ionizing Radiation Triggers Prolonged Changes in Circular RNA Abundance in the Embryonic Mouse Brain and Primary Neurons.		circ-0009175	mmu_circ_Ano3	Ano3	ionizing radiation exposure 	MONDO:0043458	radiation injury	up-regulated	RT-qPCR	"circ-0009175 is an Ano3-derived circRNA validated as a circRNA and shown to increase during neuronal maturation in vitro. It belongs to the Ano3 circRNA set that is induced after irradiation with delayed kinetics compared with linear mRNAs, consistent with a potential long-term radiation-response marker profile."	0.4844
31357500	Cells	2019	Exposure to Ionizing Radiation Triggers Prolonged Changes in Circular RNA Abundance in the Embryonic Mouse Brain and Primary Neurons.		circ-0009176	mmu_circ_Ano3	Ano3	ionizing radiation exposure 	MONDO:0043458	radiation injury	up-regulated	RT-qPCR	"circ-0009176 is an Ano3-derived circRNA validated in the study¡¯s circRNA panel and reported to show little change during neuronal maturation. The paper indicates Ano3 circRNAs are induced after irradiation overall, but does not specify isoform-resolved radiation kinetics for circ-0009176 in the provided text."	0.4844
31357500	Cells	2019	Exposure to Ionizing Radiation Triggers Prolonged Changes in Circular RNA Abundance in the Embryonic Mouse Brain and Primary Neurons.		circ-0006330	mmu_circ_Sec14l5	Sec14l5	ionizing radiation exposure 	MONDO:0043458	radiation injury	up-regulated	RT-qPCR	circ-0006330 is the Sec14l5-derived circular isoform validated by RT-qPCR-based circularity assays and shown to be strongly induced shortly after irradiation in embryonic brain with sustained elevation to 12 h. It is enriched in brain/heart across tissues; it was not detected in primary cortical neurons in the stability assay context.	0.4844
31357500	Cells	2019	Exposure to Ionizing Radiation Triggers Prolonged Changes in Circular RNA Abundance in the Embryonic Mouse Brain and Primary Neurons.		circ-0001605	mmu_circ_Rnf169	Rnf169	ionizing radiation exposure 	MONDO:0043458	radiation injury	up-regulated	RT-qPCR	"circ-0001605 is a Rnf169-derived circRNA validated by RT-qPCR circularity assays and characterized as stable and brain-enriched with increasing abundance across brain aging. It is included among Rnf169 circRNAs that show delayed induction after irradiation in embryonic brain, contrasting with more transient mRNA responses."	0.527
31357500	Cells	2019	Exposure to Ionizing Radiation Triggers Prolonged Changes in Circular RNA Abundance in the Embryonic Mouse Brain and Primary Neurons.		circ-0013703	mmu_circ_Rnf169	Rnf169	ionizing radiation exposure 	MONDO:0043458	radiation injury	up-regulated	RT-qPCR	"circ-0013703 is a Rnf169-derived circRNA validated in the study, described as stable and increasing in abundance with brain age (with a transient dip between E18 and P10). It is part of the Rnf169 circRNA group that shows delayed induction after irradiation in embryonic brain compared with transient mRNA responses."	0.4844
31357500	Cells	2019	Exposure to Ionizing Radiation Triggers Prolonged Changes in Circular RNA Abundance in the Embryonic Mouse Brain and Primary Neurons.		circ-0013704	mmu_circ_Rnf169	Rnf169	ionizing radiation exposure 	MONDO:0043458	radiation injury	unknown	RT-qPCR	"circ-0013704 is a Rnf169-derived circRNA validated as part of the Rnf169 circRNA set, but unlike other Rnf169 circRNAs it was not among those peaking at 12 h post-irradiation in embryonic brain. Rnf169 circRNAs are described as showing little, if any, induction after irradiation and remain unchanged in blood at 10 days post whole-body irradiation."	0.4844
31360192	Archives of medical science : AMS	2019	Comprehensive analysis of differentially expressed circRNAs revealed a ceRNA network in pancreatic ductaladenocarcinoma.	hsa_circ_0006913				pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	down-regulated	Microarray	This circRNA was identified as down-regulated in PDAC from GEO microarray datasets. CLIP-seq peak evidence suggested DHX9 may bind its locus and potentially regulate its circRNA formation in PDAC.	0.1768
31360192	Archives of medical science : AMS	2019	Comprehensive analysis of differentially expressed circRNAs revealed a ceRNA network in pancreatic ductaladenocarcinoma.	hsa_circ_0049392				pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	down-regulated	Microarray	"hsa_circ_0049392 was identified as down-regulated in PDAC from GEO microarray datasets. Its genomic locus showed DHX9 CLIP-seq peaks, suggesting DHX9 may regulate its circRNA formation in PDAC."	0.1768
31360192	Archives of medical science : AMS	2019	Comprehensive analysis of differentially expressed circRNAs revealed a ceRNA network in pancreatic ductaladenocarcinoma.	hsa_circ_0005203				pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	down-regulated	Microarray	"hsa_circ_0005203 was identified as down-regulated in PDAC from GEO microarray datasets. DHX9 CLIP-seq peaks were observed at its locus, implying a potential DHX9-dependent regulation of its circRNA formation in PDAC."	0.1768
31360192	Archives of medical science : AMS	2019	Comprehensive analysis of differentially expressed circRNAs revealed a ceRNA network in pancreatic ductaladenocarcinoma.	hsa_circ_0001626				pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	down-regulated	Microarray	hsa_circ_0001626 was identified as down-regulated in PDAC via GEO microarray datasets. CLIP-seq peak analysis suggested DHX9 binds its locus and may regulate its circRNA formation in PDAC.	0.1768
31369204	FEBS open bio	2019	Profiling and functional analysis of differentially expressed circular RNAs in high glucose-induced human umbilical vein endothelial cells.	hsa_circ_0008360		hsa_circ_XPNPEP3	XPNPEP3	diabetes-associated endothelial dysfunction 	MONDO:0005015	diabetes mellitus	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0008360 is up-regulated in high glucose-induced HUVECs and is bioinformatically predicted to sponge several miRNAs (including hsa-miR-186-3p), suggesting a potential ceRNA-like regulatory role in endothelial dysfunction/angiogenesis-related gene regulation, but downstream targets and functions were not experimentally validated."	0.2465
31369204	FEBS open bio	2019	Profiling and functional analysis of differentially expressed circular RNAs in high glucose-induced human umbilical vein endothelial cells.	hsa_circ_0005741		hsa_circ_FBXW4	FBXW4	diabetic vascular complications 	MONDO:0000960	diabetic peripheral angiopathy	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005741 is up-regulated in high glucose-induced HUVECs (validated by RT-qPCR), suggesting it is associated with hyperglycemia-related endothelial dysfunction, but no specific downstream mechanism or functional assays were reported for this circRNA."	0.1904
31369204	FEBS open bio	2019	Profiling and functional analysis of differentially expressed circular RNAs in high glucose-induced human umbilical vein endothelial cells.	hsa_circ_0003250				diabetic vascular complications 	MONDO:0000960	diabetic peripheral angiopathy	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0003250 is up-regulated in high glucose-induced HUVECs (validated by RT-qPCR) and is part of the dysregulated circRNA landscape under hyperglycemic stress, but the study did not report specific miRNA targets or functional/mechanistic assays for this circRNA."	0.1904
31369204	FEBS open bio	2019	Profiling and functional analysis of differentially expressed circular RNAs in high glucose-induced human umbilical vein endothelial cells.	hsa_circ_0045462				diabetic vascular complications 	MONDO:0000960	diabetic peripheral angiopathy	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0045462 is up-regulated in high glucose-induced HUVECs (validated by RT-qPCR), indicating association with hyperglycemia-related endothelial dysfunction, but the study did not provide specific mechanistic interactions or functional validation for this circRNA."	0.1904
31369204	FEBS open bio	2019	Profiling and functional analysis of differentially expressed circular RNAs in high glucose-induced human umbilical vein endothelial cells.	hsa_circ_0064772		hsa_circ_CLASP2	CLASP2	diabetic vascular complications 	MONDO:0000960	diabetic peripheral angiopathy	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0064772 is down-regulated in high glucose-induced HUVECs (validated by RT-qPCR). Although bioinformatic miRNA target predictions were provided, this study did not experimentally validate a mechanism or functional effect for hsa_circ_0064772."	0.1904
31369204	FEBS open bio	2019	Profiling and functional analysis of differentially expressed circular RNAs in high glucose-induced human umbilical vein endothelial cells.	hsa_circ_0007976		hsa_circ_HIF1A	HIF1A	diabetic vascular complications 	MONDO:0000960	diabetic peripheral angiopathy	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0007976 is down-regulated in high glucose-induced HUVECs (validated by RT-qPCR). The study provides only predicted miRNA binding information and does not experimentally validate functional effects or a downstream mechanism for this circRNA.	0.1904
31369204	FEBS open bio	2019	Profiling and functional analysis of differentially expressed circular RNAs in high glucose-induced human umbilical vein endothelial cells.	hsa_circ_0005263		hsa_circ_FNDC3A	FNDC3A	diabetic vascular complications 	MONDO:0000960	diabetic peripheral angiopathy	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005263 is down-regulated in high glucose-induced HUVECs (validated by RT-qPCR). Predicted miRNA targets were listed, but the study did not experimentally validate downstream targets or biological functions for this circRNA."	0.1904
31369204	FEBS open bio	2019	Profiling and functional analysis of differentially expressed circular RNAs in high glucose-induced human umbilical vein endothelial cells.	hsa_circ_0000109		hsa_circ_CAPZA1	CAPZA1	diabetes-associated endothelial dysfunction 	MONDO:0005015	diabetes mellitus	up-regulated	RNA-seq	"hsa_circ_0000109 is among the most up-regulated circRNAs in high glucose-induced HUVECs based on RNA-seq and is used to build a predicted circRNA_miRNA interaction network (e.g., involving miR-370-5p), but it was not RT-qPCR validated and no functional experiments were performed for it."	0.1768
31369204	FEBS open bio	2019	Profiling and functional analysis of differentially expressed circular RNAs in high glucose-induced human umbilical vein endothelial cells.	hsa_circ_0002317				diabetes-associated endothelial dysfunction 	MONDO:0005015	diabetes mellitus	up-regulated	RNA-seq	"hsa_circ_0002317 is strongly up-regulated in high glucose-induced HUVECs based on RNA-seq and is used to construct a predicted circRNA_miRNA interaction network with many candidate miRNA targets (e.g., miR-149-3p). It was not RT-qPCR validated and no direct functional/mechanistic experiments were performed for this circRNA in the study."	0.1768
31369587	PloS one	2019	Molecular network-based identification of competing endogenous RNAs in bladder cancer.	hsa_circ_0000144				bladder cancer 	MONDO:0004986	urinary bladder carcinoma	dysregulated	Microarray	"This study identifies hsa_circ_0000144 as a dysregulated circRNA in bladder cancer via public-dataset differential expression and inclusion in a predicted circRNA_miRNA_mRNA ceRNA network, suggesting potential biomarker relevance. No specific miRNA/mRNA axis or experimental functional validation was provided for this circRNA."	0.1768
31369587	PloS one	2019	Molecular network-based identification of competing endogenous RNAs in bladder cancer.	hsa_circ_0023642				bladder cancer 	MONDO:0004986	urinary bladder carcinoma	dysregulated	Microarray	"This study identifies hsa_circ_0023642 as a dysregulated circRNA in bladder cancer via public-dataset differential expression and inclusion in a predicted circRNA_miRNA_mRNA ceRNA network, suggesting potential biomarker relevance. No specific miRNA/mRNA axis or experimental functional validation was provided for this circRNA."	0.1768
31371702	Cell death & disease	2019	circHECTD1 facilitates glutaminolysis to promote gastric cancer progression by targeting miR-1256 and activating beta-catenin/c-Myc signaling.		circHECTD1	hsa_circ_HECTD1	hectd1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"circHECTD1 is upregulated in gastric cancer and acts as an oncogenic circRNA. It sponges miR-1256 to increase USP5 expression, activating beta-catenin/c-Myc signaling to enhance glutaminolysis and promote proliferation, migration, invasion, and tumor growth; high circHECTD1 predicts poor prognosis."	0.8715
31372051	Cancer management and research	2019	"Circ-ITGA7 sponges miR-3187-3p to upregulate ASXL1, suppressing colorectal cancer proliferation."	hsa_circ_0026782		hsa_circ_ITGA7	ITGA7	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	"circ-ITGA7 is significantly down-regulated in colorectal cancer tissues and CRC cell lines. It suppresses CRC cell proliferation by acting as a ceRNA sponge for miR-3187-3p, relieving repression of ASXL1 (via ASXL1 5¡ä-UTR), and it promotes apoptosis and G1-phase arrest in vitro."	0.7933
31372241	Cell death discovery	2019	CircRNA_101505 sensitizes hepatocellular carcinoma cells to cisplatin by sponging miR-103 and promotes oxidored-nitro domain-containing protein 1 expression.		circRNA_101505			hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"circRNA_101505 is down-regulated in HCC, especially in cisplatin-resistant tissues/cell lines, and low expression correlates with worse overall survival. Functionally, circRNA_101505 suppresses proliferation, promotes apoptosis, and increases cisplatin sensitivity by sponging miR-103 to upregulate NOR1."	0.7789
31384171	Cancer cell international	2019	Upregulation of circFLNA contributes to laryngeal squamous cell carcinoma migration by circFLNA-miR-486-3p-FLNA axis.	hsa_circ_0092012		hsa_circ_FLNA	FLNA	laryngeal squamous cell carcinoma 	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR	"circFLNA (hsa_circ_0092012), derived from FLNA, is up-regulated in LSCC and correlates with lymph node metastasis. It promotes LSCC cell migration by sponging miR-486-3p, thereby relieving miR-486-3p-mediated suppression of FLNA and increasing FLNA (and MMP2) protein levels."	0.7475
31397348	Neural regeneration research	2019	Novel circular RNAs expressed in brain microvascular endothelial cells after oxygen-glucose deprivation/recovery.		novel_circ_0003760			cerebral ischemia reperfusion injury 	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR; RNA-seq	"novel_circ_0003760 is up-regulated in rat BMECs after OGD/R and was validated by RT-qPCR. The study constructed a predicted circRNA_miRNA interaction network for this circRNA, supporting a potential miRNA-sponge role in ischemia-reperfusion-related endothelial dysfunction."	0.2465
31397348	Neural regeneration research	2019	Novel circular RNAs expressed in brain microvascular endothelial cells after oxygen-glucose deprivation/recovery.		novel_circ_0002086			cerebral ischemia reperfusion injury 	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR; RNA-seq	novel_circ_0002086 is up-regulated in rat BMECs after OGD/R and was validated by RT-qPCR. The study predicted several interacting miRNAs for novel_circ_0002086 via bioinformatic circRNA_miRNA network analysis.	0.2465
31397348	Neural regeneration research	2019	Novel circular RNAs expressed in brain microvascular endothelial cells after oxygen-glucose deprivation/recovery.		novel_circ_0001606			cerebral ischemia reperfusion injury 	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR; RNA-seq	novel_circ_0001606 is up-regulated in rat BMECs after OGD/R and was validated by RT-qPCR. The study predicted multiple interacting miRNAs for novel_circ_0001606 using Miranda-based circRNA_miRNA network analysis.	0.2465
31397348	Neural regeneration research	2019	Novel circular RNAs expressed in brain microvascular endothelial cells after oxygen-glucose deprivation/recovery.		novel_circ_0002023			cerebral ischemia reperfusion injury 	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR; RNA-seq	novel_circ_0002023 is up-regulated in rat BMECs after OGD/R and was validated by RT-qPCR. The paper provides a bioinformatically predicted set of miRNAs that may interact with novel_circ_0002023 in a circRNA_miRNA network.	0.2465
31397348	Neural regeneration research	2019	Novel circular RNAs expressed in brain microvascular endothelial cells after oxygen-glucose deprivation/recovery.		novel_circ_0000173			cerebral ischemia reperfusion injury 	MONDO:0005203	ischemia reperfusion injury	down-regulated	RT-qPCR; RNA-seq	"novel_circ_0000173 is down-regulated in rat BMECs after OGD/R and was validated by RT-qPCR. The study predicted a set of interacting miRNAs for this circRNA within a circRNA_miRNA network, consistent with a potential miRNA-sponge role."	0.2465
31397348	Neural regeneration research	2019	Novel circular RNAs expressed in brain microvascular endothelial cells after oxygen-glucose deprivation/recovery.		novel_circ_0004586			cerebral ischemia reperfusion injury 	MONDO:0005203	ischemia reperfusion injury	down-regulated	RT-qPCR; RNA-seq	"novel_circ_0004586 is down-regulated in rat BMECs after OGD/R and was validated by RT-qPCR. Bioinformatic analysis predicted that it may interact with miR-124 and other miRNAs, suggesting a potential miRNA-sponge role in ischemia-reperfusion-related endothelial responses."	0.2465
31397348	Neural regeneration research	2019	Novel circular RNAs expressed in brain microvascular endothelial cells after oxygen-glucose deprivation/recovery.		novel_circ_0003342			cerebral ischemia reperfusion injury 	MONDO:0005203	ischemia reperfusion injury	down-regulated	RT-qPCR; RNA-seq	novel_circ_0003342 is down-regulated in rat BMECs after OGD/R and was validated by RT-qPCR. The study predicted a circRNA_miRNA network and noted a potential interaction with miR-143.	0.2465
31397348	Neural regeneration research	2019	Novel circular RNAs expressed in brain microvascular endothelial cells after oxygen-glucose deprivation/recovery.		novel_circ_0004860			cerebral ischemia reperfusion injury 	MONDO:0005203	ischemia reperfusion injury	down-regulated	RT-qPCR; RNA-seq	novel_circ_0004860 is down-regulated in rat BMECs after OGD/R and was validated by RT-qPCR. The study provides a predicted circRNA_miRNA interaction network for this circRNA.	0.2465
31397837	Cardiovascular research	2020	Circular RNA circRNA_000203 aggravates cardiac hypertrophy via suppressing miR-26b-5p and miR-140-3p binding to Gata4.		circRNA_000203	mmu_circ_Myo9a	Myo9a	cardiac hypertrophy 	MONDO:0001302	hypertensive heart disease	up-regulated	RT-qPCR	"circRNA_000203 is up-regulated in Ang-II-induced cardiac hypertrophy and promotes hypertrophic growth in cardiomyocytes. It functions mainly in the cytoplasm as a ceRNA, sponging miR-26b-5p and miR-140-3p to relieve repression of Gata4 and increase GATA4, thereby exacerbating hypertrophy. NF-kappaB signaling contributes to Ang-II-driven up-regulation of circRNA_000203."	0.7437
31400606	Molecular therapy. Nucleic acids	2019	A Novel Circular RNA Mediates Pyroptosis of Diabetic Cardiomyopathy by Functioning as a Competing Endogenous RNA.	hsa_circ_0076631		hsa_circ_SLC29A1	SLC29A1	Diabetic cardiomyopathy 	MONDO:0004994	cardiomyopathy	up-regulated	RT-qPCR	"CACR (hsa_circ_0076631, from SLC29A1) is up-regulated in high-glucose-treated human cardiomyocytes and in serum from diabetic patients. It localizes to both nucleus and cytoplasm and acts as a ceRNA by sponging miR-214-3p, thereby de-repressing caspase-1 and promoting pyroptosis-associated inflammation and cardiomyocyte death; CACR knockdown alleviates these effects."	0.6777
31400609	Molecular therapy. Nucleic acids	2019	Circular RNA circSCAF11 Accelerates the Glioma Tumorigenesis through the miR-421/SP1/VEGFA Axis.	hsa_circ_0098619		hsa_circ_SCAF11	SCAF11	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circSCAF11 is up-regulated in glioma and functions as an oncogenic circRNA. It sponges miR-421 to increase SP1, which transcriptionally activates VEGFA, thereby promoting glioma proliferation, invasion, tumor growth, and angiogenesis-related progression, and its high expression predicts poorer survival."	0.8436
31401644	Medical science monitor : international medical journal of experimental and clinical research	2019	Expression of circZNF609 is Down-Regulated in Colorectal Cancer Tissue and Promotes Apoptosis in Colorectal Cancer Cells by Upregulating p53.	hsa_circ_0000615		hsa_circ_ZNF609	ZNF609	colorectal cancer	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"circZNF609 is down-regulated in colorectal cancer tissues and patient serum. Its overexpression in HCT116 cells inhibits cell activity and promotes apoptosis, accompanied by increased p53 and Bax and decreased Bcl-2, suggesting a pro-apoptotic role via p53 upregulation. Serum circZNF609 shows potential diagnostic value based on ROC analysis."	0.7353
31402547	Journal of cellular and molecular medicine	2019	Circ_0136474 and MMP-13 suppressed cell proliferation by competitive binding to miR-127-5p in osteoarthritis.	hsa_circ_0136474				osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; RNA-seq	"Circ_0136474 is up-regulated in osteoarthritis cartilage and localizes to both nucleus and cytoplasm. It functions as a sponge for miR-127-5p to increase MMP-13 expression, leading to reduced chondrocyte proliferation and increased apoptosis, with associated increases in inflammatory cytokines (IL-1beta, TNF-alpha, IL-17) and reduced collagen type II."	0.7489
31409777	Cell death & disease	2019	Circular RNA PRKCI promotes glioma cell progression by inhibiting microRNA-545.			hsa_circ_PRKCI	PRKCI	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circPRKCI is up-regulated in human glioma tissues and glioma cells and functions as an oncogenic circRNA. It promotes glioma cell proliferation/survival and migration and suppresses apoptosis, mainly by sponging miR-545 and thereby modulating miR-545 targets such as E2F7 and RIG-1; circPRKCI knockdown suppresses A172 xenograft growth in mice."	0.6833
31409897	Oncogene	2019	Circular RNAs add diversity to androgen receptor isoform repertoire in castration-resistant prostate cancer.		circAR_E2In1	hsa_circ_AR	AR	metastatic castration-resistant prostate cancer 	MONDO:0850353	castration-resistant prostate carcinoma	up-regulated	RT-qPCR; RNA-seq	circAR_E2In1 is an AR-derived circRNA upregulated during castration-resistant progression in LuCaP PDX models and correlated with linear AR/AR-variant expression in mCRPC samples. It localizes predominantly to the cytoplasm and is proposed as a potential circulating biomarker reflecting AR transcriptional output.	0.7008
31409897	Oncogene	2019	Circular RNAs add diversity to androgen receptor isoform repertoire in castration-resistant prostate cancer.		circAR_E2In2	hsa_circ_AR	AR	metastatic castration-resistant prostate cancer 	MONDO:0850353	castration-resistant prostate carcinoma	up-regulated	RT-qPCR; RNA-seq	"circAR_E2In2 is upregulated in castration-resistant PDX tumors and its expression tracks with linear AR/AR-variant transcription, consistent with transcriptional regulation rather than a global increase in circRNA formation. It is predominantly cytoplasmic and is discussed as part of an AR-circRNA set with potential biomarker value in mCRPC."	0.695
31409897	Oncogene	2019	Circular RNAs add diversity to androgen receptor isoform repertoire in castration-resistant prostate cancer.		circAR_E3	hsa_circ_AR	AR	metastatic castration-resistant prostate cancer 	MONDO:0850353	castration-resistant prostate carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circAR_E3 is an AR-derived circRNA significantly upregulated in castration-resistant PDX tumors and predominantly localized in the cytoplasm, validated by fractionation and BaseScope RISH. It is discussed as part of a circAR biomarker set for mCRPC, and it has hypothesized peptide-coding potential based on an open reading frame."	0.7008
31409897	Oncogene	2019	Circular RNAs add diversity to androgen receptor isoform repertoire in castration-resistant prostate cancer.		circAR_E2	hsa_circ_AR	AR	metastatic castration-resistant prostate cancer 	MONDO:0850353	castration-resistant prostate carcinoma	up-regulated	RT-qPCR; RNA-seq	"circAR_E2 is an abundant AR-derived circRNA upregulated during castration-resistant progression in LuCaP PDXs and predominantly cytoplasmic. It is detectable in plasma from mCRPC patients by RT-PCR with Sanger confirmation, supporting its proposed use as a non-invasive surrogate marker of AR/AR-variant transcriptional activity."	0.695
31410028	OncoTargets and therapy	2019	Hsa_circ_0003998 may be used as a new biomarker for the diagnosis and prognosis of hepatocellular carcinoma.	hsa_circ_0003998		hsa_circ_ARFGEF2	ARFGEF2	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0003998 is up-regulated in HCC tissues, HCC cell lines, and patient plasma, and decreases after surgery, supporting its diagnostic utility. High hsa_circ_0003998 expression correlates with worse overall survival and is an independent prognostic factor for HCC. Mechanistically, the study provides bioinformatic predictions that it may act as a miRNA sponge, but no functional/axis validation was performed."	0.6663
31411002	Journal of cellular and molecular medicine	2019	Characteristics of circular RNA expression of pulmonary macrophages in mice with sepsis-induced acute lung injury.		chr17:71273374-71275287-			sepsis-induced acute lung injury 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR; RNA-seq	"This up-regulated circRNA in CLP-induced ALI pulmonary macrophages is predicted to sponge mmu-miR-7c-5p, potentially suppressing M2-associated anti-inflammatory miRNA activity and thereby favoring M1 polarization and worsening lung injury."	0.3684
31411002	Journal of cellular and molecular medicine	2019	Characteristics of circular RNA expression of pulmonary macrophages in mice with sepsis-induced acute lung injury.		chr14:57733878-57734418-			sepsis-induced acute lung injury 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR; RNA-seq	"This up-regulated circRNA in CLP-induced ALI pulmonary macrophages is predicted to sponge mmu-miR-132-3p, potentially suppressing M2-associated anti-inflammatory miRNA activity and thereby favoring M1 polarization and worsening lung injury."	0.3684
31411002	Journal of cellular and molecular medicine	2019	Characteristics of circular RNA expression of pulmonary macrophages in mice with sepsis-induced acute lung injury.		chr18:10119885-10132272-			sepsis-induced acute lung injury 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR; RNA-seq	"This up-regulated circRNA in CLP-induced ALI pulmonary macrophages is predicted to sponge mmu-miR-124-3p, potentially suppressing M2-associated anti-inflammatory miRNA activity and thereby favoring M1 polarization and worsening lung injury."	0.3684
31413634	Cancer management and research	2019	Circular RNA hsa_circRNA_102958 promotes tumorigenesis of colorectal cancer via miR-585/CDC25B axis.		hsa_circRNA_102958			colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH	"hsa_circRNA_102958 is up-regulated in colorectal cancer and functions as an oncogenic circRNA. It promotes CRC proliferation, migration, invasion and xenograft tumor growth by sponging miR-585 to de-repress CDC25B expression, and high expression predicts poorer patient survival."	0.7588
31413665	Cancer cell international	2019	Circular RNA MYLK promotes hepatocellular carcinoma progression by increasing Rab23 expression by sponging miR-362-3p.			hsa_circ_MYLK	MYLK	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circMYLK is up-regulated in HCC and promotes proliferation, invasion/migration, and xenograft tumor growth. Mechanistically, it acts as a ceRNA to sponge miR-362-3p, relieving repression of Rab23 and activating the miR-362-3p/Rab23 axis, and high circMYLK expression associates with poorer patient survival."	0.7657
31417632	Journal of Cancer	2019	CircABCC2 Regulates Hepatocellular Cancer Progression by Decoying MiR-665.	hsa_circ_0019456	circABCC2	hsa_circ_ABCC2	ABCC2	hepatocellular cancer 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circABCC2 is up-regulated in HCC tissues and cell lines and promotes malignant phenotypes (proliferation and invasion) while inhibiting apoptosis. Mechanistically, circABCC2 is mainly cytoplasmic and functions as a ceRNA by sponging miR-665 to increase ABCC2 expression, thereby promoting HCC progression in vitro and in xenograft models."	0.742
31417634	Journal of Cancer	2019	circGFRA1 Promotes Ovarian Cancer Progression By Sponging miR-449a.		circGFRA1	hsa_circ_GFRA1	GFRA1	ovarian cancer	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circGFRA1 is up-regulated in ovarian cancer tissues and promotes malignant phenotypes (proliferation, invasion, and in vivo tumor growth/metastasis) while inhibiting apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-449a to increase GFRA1 expression."	0.7099
31420566	Scientific reports	2019	Possible epigenetic regulatory effect of dysregulated circular RNAs in Alzheimer's disease model.		mmu_circRNA_28972	mmu_circ_Lrrk2	Lrrk2	Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	up-regulated	Microarray	"mmu_circRNA_28972 is reported as up-regulated in Tg2576 mouse brain (7 months) based on circRNA microarray. The study suggests dysregulated circRNAs may modulate downstream mRNAs through predicted circRNA_miRNA_mRNA networks, but does not validate a specific axis for this circRNA."	0.1155
31420566	Scientific reports	2019	Possible epigenetic regulatory effect of dysregulated circular RNAs in Alzheimer's disease model.		mmu_circRNA_28971	mmu_circ_Lrrk2	Lrrk2	Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	up-regulated	Microarray	"mmu_circRNA_28971 is reported as up-regulated in Tg2576 mouse brain (7 months) based on circRNA microarray. The study suggests dysregulated circRNAs may modulate downstream mRNAs through predicted circRNA_miRNA_mRNA networks, but does not validate a specific axis for this circRNA."	0.1155
31420566	Scientific reports	2019	Possible epigenetic regulatory effect of dysregulated circular RNAs in Alzheimer's disease model.		mmu_circRNA_29980	mmu_circ_App	App	Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	up-regulated	Microarray	"mmu_circRNA_29980 (host gene App) is up-regulated in Tg2576 mouse brain at both 7 and 12 months. The study positions it within predicted circRNA_miRNA_mRNA regulatory networks potentially affecting AD-relevant mRNAs, without experimentally validating specific interactions."	0.1155
31420566	Scientific reports	2019	Possible epigenetic regulatory effect of dysregulated circular RNAs in Alzheimer's disease model.		mmu_circRNA_35502	mmu_circ_Vmn2r1	Vmn2r1	Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	up-regulated	Microarray	"mmu_circRNA_35502 is up-regulated in Tg2576 mouse brain (7 months) by circRNA microarray. The paper suggests dysregulated circRNAs may influence AD pathogenesis via predicted circRNA_miRNA_mRNA networks, but provides no circRNA-specific mechanistic validation."	0.1155
31420566	Scientific reports	2019	Possible epigenetic regulatory effect of dysregulated circular RNAs in Alzheimer's disease model.		mmu_circRNA_39081	mmu_circ_Sparcl1	Sparcl1	Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	up-regulated	Microarray	"mmu_circRNA_39081 is up-regulated in Tg2576 mouse brain (7 months) by circRNA microarray. The work suggests dysregulated circRNAs may influence AD-relevant mRNA dysregulation through predicted circRNA_miRNA_mRNA networks, without validating a specific mechanism for this circRNA."	0.1155
31420566	Scientific reports	2019	Possible epigenetic regulatory effect of dysregulated circular RNAs in Alzheimer's disease model.		mmu_circRNA_22066	mmu_circ_Sh3rf3	Sh3rf3	Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	down-regulated	Microarray	"mmu_circRNA_22066 is down-regulated in Tg2576 mouse brain (7 months) according to circRNA microarray. The study frames dysregulated circRNAs as potential upstream regulators of AD-related mRNA changes through predicted circRNA_miRNA_mRNA networks, without circRNA-specific functional validation."	0.1155
31420566	Scientific reports	2019	Possible epigenetic regulatory effect of dysregulated circular RNAs in Alzheimer's disease model.		mmu_circRNA_001769	mmu_circ_Rn45s	Rn45s	Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	down-regulated	Microarray	"mmu_circRNA_001769 (host gene Rn45s) is down-regulated in Tg2576 mouse brain (7 months) based on circRNA microarray. The paper proposes that dysregulated circRNAs may contribute to AD pathogenesis via predicted circRNA_miRNA_mRNA networks, without validating specific interactions for this circRNA."	0.1155
31420566	Scientific reports	2019	Possible epigenetic regulatory effect of dysregulated circular RNAs in Alzheimer's disease model.		mmu_circRNA_30284	mmu_circ_Vmn2r107	Vmn2r107	Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	down-regulated	Microarray	"mmu_circRNA_30284 is down-regulated in Tg2576 mouse brain (7 months) by circRNA microarray. The study provides a global, predicted circRNA_miRNA_mRNA network framework for AD but no specific mechanistic validation for this circRNA."	0.1155
31420566	Scientific reports	2019	Possible epigenetic regulatory effect of dysregulated circular RNAs in Alzheimer's disease model.		mmu_circRNA_011516	mmu_circ_Npcd	Npcd	Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	down-regulated	Microarray	mmu_circRNA_011516 is down-regulated in Tg2576 mouse brain (7 months) based on circRNA microarray. The paper proposes a predicted circRNA_miRNA_mRNA network involvement in AD without validating specific interactions for this circRNA.	0.1155
31420566	Scientific reports	2019	Possible epigenetic regulatory effect of dysregulated circular RNAs in Alzheimer's disease model.		mmu_circRNA_19403	mmu_circ_Uspl1	Uspl1	Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	down-regulated	Microarray	"mmu_circRNA_19403 is down-regulated in Tg2576 mouse brain (7 months) by circRNA microarray. The study implicates dysregulated circRNAs in AD through predicted circRNA_miRNA_mRNA regulation, without validating specific downstream targets for this circRNA."	0.1155
31420566	Scientific reports	2019	Possible epigenetic regulatory effect of dysregulated circular RNAs in Alzheimer's disease model.		mmu_circRNA_45982	mmu_circ_Mid1	Mid1	Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	up-regulated	Microarray	"mmu_circRNA_45982 is up-regulated in Tg2576 mouse brain (12 months) based on circRNA microarray. The paper suggests dysregulated circRNAs may impact AD through predicted circRNA_miRNA_mRNA networks, without validating specific targets for this circRNA."	0.1155
31420566	Scientific reports	2019	Possible epigenetic regulatory effect of dysregulated circular RNAs in Alzheimer's disease model.		mmu_circRNA_23412	mmu_circ_Larp1	Larp1	Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	up-regulated	Microarray	"mmu_circRNA_23412 is up-regulated in Tg2576 mouse brain (12 months) based on circRNA microarray. The paper proposes that dysregulated circRNAs may affect AD-relevant mRNA patterns via predicted circRNA_miRNA_mRNA interactions, without circRNA-specific validation."	0.1155
31420566	Scientific reports	2019	Possible epigenetic regulatory effect of dysregulated circular RNAs in Alzheimer's disease model.		mmu_circRNA_19523	mmu_circ_Zfp609	Zfp609	Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	up-regulated	Microarray	"mmu_circRNA_19523 is up-regulated in Tg2576 mouse brain (12 months) based on circRNA microarray. The study suggests dysregulated circRNAs may contribute to AD via predicted circRNA_miRNA_mRNA networks, without circRNA-specific mechanistic validation."	0.1155
31420566	Scientific reports	2019	Possible epigenetic regulatory effect of dysregulated circular RNAs in Alzheimer's disease model.		mmu_circRNA_012412	mmu_circ_Rn45s	Rn45s	Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	up-regulated	Microarray	mmu_circRNA_012412 (host gene Rn45s) is up-regulated in Tg2576 mouse brain (12 months) based on circRNA microarray. The study proposes a predicted circRNA_miRNA_mRNA regulatory role in AD without validating targets for this circRNA.	0.1155
31420566	Scientific reports	2019	Possible epigenetic regulatory effect of dysregulated circular RNAs in Alzheimer's disease model.		mmu_circRNA_34884	mmu_circ_Ralgapb	Ralgapb	Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	down-regulated	Microarray	"mmu_circRNA_34884 is down-regulated in Tg2576 mouse brain (12 months) based on circRNA microarray. The study links dysregulated circRNAs to predicted circRNA_miRNA_mRNA networks relevant to AD, without validating a specific mechanism for this circRNA."	0.1155
31420566	Scientific reports	2019	Possible epigenetic regulatory effect of dysregulated circular RNAs in Alzheimer's disease model.		mmu_circRNA_008816	mmu_circ_Mipep	Mipep	Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	down-regulated	Microarray	"mmu_circRNA_008816 is down-regulated in Tg2576 mouse brain (12 months) based on circRNA microarray. The paper suggests dysregulated circRNAs may affect AD-relevant mRNAs via predicted circRNA_miRNA_mRNA networks, without specific interaction validation for this circRNA."	0.1155
31420566	Scientific reports	2019	Possible epigenetic regulatory effect of dysregulated circular RNAs in Alzheimer's disease model.		mmu_circRNA_37345	mmu_circ_Scp2	Scp2	Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	down-regulated	Microarray	mmu_circRNA_37345 is down-regulated in Tg2576 mouse brain (12 months) based on circRNA microarray. The study proposes predicted circRNA_miRNA_mRNA regulatory involvement in AD without validating specific targets for this circRNA.	0.1155
31420566	Scientific reports	2019	Possible epigenetic regulatory effect of dysregulated circular RNAs in Alzheimer's disease model.		mmu_circRNA_45069	mmu_circ_Dock3	Dock3	Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	down-regulated	Microarray	"mmu_circRNA_45069 is down-regulated in Tg2576 mouse brain (12 months) based on circRNA microarray. The study implies dysregulated circRNAs may influence AD pathogenesis through predicted circRNA_miRNA_mRNA networks, without validating specific interactions for this circRNA."	0.1155
31420566	Scientific reports	2019	Possible epigenetic regulatory effect of dysregulated circular RNAs in Alzheimer's disease model.		mmu_circRNA_35843	mmu_circ_Vps45	Vps45	Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	down-regulated	Microarray	mmu_circRNA_35843 is down-regulated in Tg2576 mouse brain (12 months) based on circRNA microarray. The study links dysregulated circRNAs to AD-relevant predicted circRNA_miRNA_mRNA networks without validating specific interactions for this circRNA.	0.1155
31420917	Journal of clinical laboratory analysis	2019	Hsa_circ_101882 promotes migration and invasion of gastric cancer cells by regulating EMT.		hsa_circ_101882			gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_101882 is up-regulated in gastric cancer tissues and GC cell lines and is associated with worse survival. Functionally, its knockdown suppresses proliferation, colony formation, migration and invasion, induces G1 arrest and promotes apoptosis. Mechanistically, it promotes metastasis-related behavior by activating EMT, decreasing E-cadherin and increasing mesenchymal markers (N-cadherin, vimentin, Snail)."	0.6778
31421050	Medical science monitor : international medical journal of experimental and clinical research	2019	Role of CircRNAs_100395 in Proliferation and Metastases of Liver Cancer.		circRNAs_100395	hsa_circ_KLHL20	KLHL20	liver cancer 	MONDO:0002691	liver cancer	down-regulated	RT-qPCR	"circ_100395 is down-regulated in liver cancer and acts as a tumor suppressor. Its overexpression inhibits proliferation, migration/invasion and EMT while promoting apoptosis, at least partly by directly binding and suppressing miR-1228; higher circ_100395 is associated with longer disease-free survival."	0.7113
31424161	Journal of cellular and molecular medicine	2019	circCPA4 acts as a prognostic factor and regulates the proliferation and metastasis of glioma.	hsa_circ_0082374	circCPA4	hsa_circ_CPA4	CPA4	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; Microarray	"circCPA4 (hsa_circ_0082374), derived from CPA4, is up-regulated in glioma tissues and its high expression is associated with worse overall survival. Functionally, circCPA4 promotes glioma proliferation and metastasis. Mechanistically, it predominantly localizes in the cytoplasm and acts as a ceRNA sponge for let-7 to increase CPA4 expression via an Ago2/RISC-associated process."	0.7925
31427478	Bioscience reports	2019	Circular RNA MYLK serves as an oncogene to promote cancer progression via microRNA-195/cyclin D1 axis in laryngeal squamous cell carcinoma.		circMYLK	hsa_circ_MYLK	MYLK	laryngeal squamous cell carcinoma 	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR	"circMYLK is up-regulated in LSCC tissues and cell lines and promotes LSCC cell proliferation by accelerating G1/S cell-cycle progression. Mechanistically, circMYLK functions as a ceRNA that sponges miR-195, thereby increasing cyclin D1 expression; miR-195 restoration counteracts circMYLK-driven oncogenic effects."	0.7129
31427481	Bioscience reports	2019	Down-regulated circPAPPA suppresses the proliferation and invasion of trophoblast cells via the miR-384/STAT3 pathway.	hsa_circ_0088227		hsa_circ_PAPPA	PAPPA	preeclampsia 	MONDO:0005081	preeclampsia	down-regulated	RT-qPCR	"circPAPPA (hsa_circ_0088227) is down-regulated in placenta and plasma from preeclampsia patients. Functionally, reduced circPAPPA suppresses trophoblast proliferation and invasion by sponging miR-384 and decreasing STAT3/p-STAT3 via a circPAPPA_miR-384_STAT3 axis, suggesting biomarker/therapeutic potential in PE."	0.7968
31428151	Journal of oncology	2019	Circular RNA hsa_circRNA_0007334 is Predicted to Promote MMP7 and COL1A1 Expression by Functioning as a miRNA Sponge in Pancreatic Ductal Adenocarcinoma.	hsa_circ_0007334	circRNA_0007334	hsa_circ_MBOAT2	MBOAT2	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circRNA_0007334 is up-regulated in PDAC tissues and promotes malignant behavior (migration) in PANC-1 cells. It acts as a ceRNA by sponging hsa-miR-144-3p and hsa-miR-577 to increase MMP7 and COL1A1 expression, and is proposed as a potential PDAC diagnostic/therapeutic biomarker."	0.7291
31429492	Journal of clinical laboratory analysis	2019	Circulating plasma circular RNAs as novel diagnostic biomarkers for congenital heart disease in children.		hsa_circRNA_004183			congenital heart disease 	MONDO:0005453	congenital heart disease	down-regulated	RT-qPCR; Microarray	hsa_circRNA_004183 is down-regulated in plasma from children with CHD and shows diagnostic utility for distinguishing CHD from healthy controls by ROC analysis.	0.5963
31429492	Journal of clinical laboratory analysis	2019	Circulating plasma circular RNAs as novel diagnostic biomarkers for congenital heart disease in children.		hsa_circ_079265			congenital heart disease 	MONDO:0005453	congenital heart disease	down-regulated	RT-qPCR; Microarray	hsa_circRNA_079265 is down-regulated in plasma from children with CHD and has diagnostic value by ROC analysis; bioinformatic prediction suggests it may bind hsa-miR-328-5p.	0.5963
31429492	Journal of clinical laboratory analysis	2019	Circulating plasma circular RNAs as novel diagnostic biomarkers for congenital heart disease in children.		hsa_circ_105039			congenital heart disease 	MONDO:0005453	congenital heart disease	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_105039 is down-regulated in plasma from children with CHD and has strong diagnostic performance by ROC analysis; bioinformatic prediction suggests a ceRNA-related role via binding miRNAs (e.g., miR-20b-5p, miR-17-5p) linked to developmental genes such as WNT5A, MEF2C, TBX3 and HOXA3."	0.5963
31432107	International journal of molecular medicine	2019	Identification of circular RNAs hsa_circ_0044235 and hsa_circ_0068367 as novel biomarkers for systemic lupus erythematosus.	hsa_circ_0044235	hsa_ circ_0044235			systemic lupus erythematosus 	MONDO:0007915	systemic lupus erythematosus	down-regulated	RT-qPCR; Microarray	"hsa_circ_0044235 is significantly decreased in PBMCs of SLE patients and shows diagnostic value by ROC analysis. The study predicts miRNA targets and reports increased hsa-miR-892a in SLE PBMCs, suggesting hsa_circ_0044235 may interact with hsa-miR-892a in SLE."	0.5047
31432107	International journal of molecular medicine	2019	Identification of circular RNAs hsa_circ_0044235 and hsa_circ_0068367 as novel biomarkers for systemic lupus erythematosus.	hsa_circ_0068367	hsa_ circ_0068367			systemic lupus erythematosus 	MONDO:0007915	systemic lupus erythematosus	down-regulated	RT-qPCR; Microarray	"hsa_circ_0068367 is significantly decreased in PBMCs of SLE patients and shows diagnostic value by ROC analysis in training and independent validation cohorts (including RA disease controls). miRNA targets were predicted, but the authors indicate its effect in SLE may not occur via sponging the tested candidate miRNAs."	0.5047
31438886	BMC cancer	2019	CircRNA CBL.11 suppresses cell proliferation by sponging miR-6778-5p in colorectal cancer.			hsa_circ_CBL	CBL	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"In CRC cell lines exposed to carbon ion irradiation, circRNA CBL.11 is induced and suppresses proliferation. Mechanistically, it sponges miR-6778-5p to upregulate YWHAE and involves the p53 pathway."	0.7807
31438963	Molecular cancer	2019	Circular RNA circNHSL1 promotes gastric cancer progression through the miR-1306-3p/SIX1/vimentin axis.	hsa_circ_0006835		hsa_circ_NHSL1	NHSL1	gastric cancer	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"circNHSL1 is up-regulated in gastric cancer and promotes migration, invasion, tumor growth and metastasis. It functions mainly as a ceRNA by sponging miR-1306-3p to de-repress SIX1, which in turn transcriptionally increases Vimentin expression, driving malignant progression and correlating with poor prognosis."	0.8766
31439031	Microbiome	2019	Gut microbiota from NLRP3-deficient mice ameliorates depressive-like behaviors by regulating astrocyte dysfunction via circHIPK2.			mmu_circ_HIPK2	HIPK2	depression 	MONDO:0002050	depressive disorder	up-regulated	RT-qPCR	circHIPK2 is up-regulated in CUS-induced depressive-like mice (plasma and hippocampus) and is positioned downstream of gut microbiota changes. Inhibiting circHIPK2 (siRNA/shRNA in hippocampal astrocytes) alleviates depressive-like behaviors and rescues astrocyte dysfunction; mechanistically it is described as a miR-124 sponge affecting sigma-receptor 1.	0.5008
31441876	Medicine	2019	Integrated analysis of circular RNA-associated ceRNA network in cervical cancer: Observational Study.	hsa_circ_0084927				cervical cancer 	MONDO:0002974	cervical cancer	unknown	Microarray	"This study bioinformatically identified hsa_circ_0084927 as a key circRNA in cervical cancer and constructed predicted ceRNA modules linking it to miR-141/ZWILCH, miR-32/RANGAP1, and miR-95/CENPK. The authors propose it may be involved in CC pathogenesis and represent a potential therapeutic target, but note that experimental validation is still needed."	0.2465
31452702	Experimental and therapeutic medicine	2019	Oxygen-induced circRNA profiles and coregulatory networks in a retinopathy of prematurity mouse model.	mmu_circ_0013414				retinopathy of prematurity 	MONDO:0006952	retinopathy of prematurity	up-regulated	RT-qPCR; RNA-seq	"mmu_circ_0013414 is up-regulated in OIR mouse retinas and is included in a predicted angiogenesis-related circRNA_miRNA_mRNA ceRNA network, potentially competing with mmu-miR-203-3p to influence multiple angiogenesis-associated mRNAs."	0.3684
31452702	Experimental and therapeutic medicine	2019	Oxygen-induced circRNA profiles and coregulatory networks in a retinopathy of prematurity mouse model.	mmu_circ_0005477				retinopathy of prematurity 	MONDO:0006952	retinopathy of prematurity	up-regulated	RT-qPCR; RNA-seq	"mmu_circ_0005477 is up-regulated in OIR mouse retinas and is predicted to act as a ceRNA in an angiogenesis-related circRNA_miRNA_mRNA network, potentially sequestering mmu-miR-203-3p (and possibly mmu-miR-5128) to affect multiple angiogenesis-associated mRNAs."	0.2465
31452702	Experimental and therapeutic medicine	2019	Oxygen-induced circRNA profiles and coregulatory networks in a retinopathy of prematurity mouse model.	mmu_circ_0000668				retinopathy of prematurity 	MONDO:0006952	retinopathy of prematurity	up-regulated	RT-qPCR; RNA-seq	mmu_circ_0000668 is up-regulated in OIR mouse retinas and is predicted to participate in an angiogenesis-related ceRNA network by binding/competing for mmu-miR-203-3p and thereby influencing angiogenesis-associated mRNAs.	0.2465
31455760	Cell death & disease	2019	ERalpha-mediated alterations in circ_0023642 and miR-490-5p signaling suppress bladder cancer invasion.	hsa_circ_0023642		hsa_circ_UVRAG	UVRAG	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	unknown	RT-qPCR	"In bladder cancer cells, circ_0023642 acts as a pro-invasive circRNA by sponging miR-490-5p, thereby relieving repression of EGFR and promoting invasion/metastasis. ERalpha suppresses BCa progression by transcriptionally downregulating the host gene UVRAG, which reduces circ_0023642 and activates the miR-490-5p-mediated inhibition of EGFR."	0.7754
31456594	Medical science monitor : international medical journal of experimental and clinical research	2019	Circular RNA CircMTO1 Inhibits Proliferation of Glioblastoma Cells via miR-92/WWOX Signaling Pathway.		circMTO1	hsa_circ_MTO1	MTO1	glioblastoma	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR	"circMTO1 is down-regulated in glioblastoma and its low expression is associated with shorter overall survival. Functionally, circMTO1 suppresses glioblastoma cell proliferation by sponging miR-92 and thereby upregulating the tumor suppressor WWOX."	0.7078
31470874	Molecular cancer	2019	A novel tumor suppressor protein encoded by circular AKT3 RNA inhibits glioblastoma tumorigenicity by competing with active phosphoinositide-dependent Kinase-1.	hsa_circ_0017250		hsa_circ_AKT3	AKT3	glioblastoma 	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR; Northern Blot; RNA-seq	"circ-AKT3 (hsa_circ_0017250) is down-regulated in glioblastoma and is mainly cytoplasmic. It encodes the tumor-suppressive peptide AKT3-174aa, which binds p-PDK1 and reduces AKT Thr308 phosphorylation, thereby inhibiting PI3K/AKT signaling and malignant phenotypes such as proliferation, radioresistance, and in vivo tumorigenicity."	0.7941
31475036	Frontiers in genetics	2019	Identification of Potential Immune-Related circRNA-miRNA-mRNA Regulatory Network in Intestine of Paralichthys olivaceus During Edwardsiella tarda Infection.		novel_circ_0001462			Edwardsiella tarda infection 	MONDO:1014977		dysregulated	RT-qPCR; RNA-seq	"novel_circ_0001462 is a differentially expressed circRNA in posterior intestine of Paralichthys olivaceus after Edwardsiella tarda challenge, supported by RNA-seq and validated by RT-qPCR/Sanger sequencing among selected DE-circRNAs."	0.6262
31475036	Frontiers in genetics	2019	Identification of Potential Immune-Related circRNA-miRNA-mRNA Regulatory Network in Intestine of Paralichthys olivaceus During Edwardsiella tarda Infection.		novel_circ_0002610			Edwardsiella tarda infection 	MONDO:1014977		dysregulated	RT-qPCR; RNA-seq	novel_circ_0002610 is a DE-circRNA during Edwardsiella tarda infection in olive flounder intestine; it was validated by RT-qPCR/Sanger sequencing and is included in a predicted ceRNA module novel_circ_0002610_novel_144_nectin2 implicated in host immune response.	0.6521
31475036	Frontiers in genetics	2019	Identification of Potential Immune-Related circRNA-miRNA-mRNA Regulatory Network in Intestine of Paralichthys olivaceus During Edwardsiella tarda Infection.		novel_circ_0002746			Edwardsiella tarda infection 	MONDO:1014977		dysregulated	RT-qPCR; RNA-seq	novel_circ_0002746 is a DE-circRNA in olive flounder posterior intestine after Edwardsiella tarda infection and was among circRNAs validated by RT-qPCR/Sanger sequencing to support sequencing results.	0.6262
31475036	Frontiers in genetics	2019	Identification of Potential Immune-Related circRNA-miRNA-mRNA Regulatory Network in Intestine of Paralichthys olivaceus During Edwardsiella tarda Infection.		novel_circ_0003643			Edwardsiella tarda infection 	MONDO:1014977		dysregulated	RT-qPCR; RNA-seq	novel_circ_0003643 is a DE-circRNA in olive flounder posterior intestine after Edwardsiella tarda infection and was among circRNAs validated by RT-qPCR/Sanger sequencing to support sequencing results.	0.6262
31475036	Frontiers in genetics	2019	Identification of Potential Immune-Related circRNA-miRNA-mRNA Regulatory Network in Intestine of Paralichthys olivaceus During Edwardsiella tarda Infection.		novel_circ_0003068			Edwardsiella tarda infection 	MONDO:1014977		dysregulated	RT-qPCR; RNA-seq	"novel_circ_0003068 is a DE-circRNA during Edwardsiella tarda infection in olive flounder intestine; it was validated by RT-qPCR/Sanger sequencing and participates in predicted ceRNA edges with novel_51 and novel_144, including a module linked to nectin2."	0.6521
31475036	Frontiers in genetics	2019	Identification of Potential Immune-Related circRNA-miRNA-mRNA Regulatory Network in Intestine of Paralichthys olivaceus During Edwardsiella tarda Infection.		novel_circ_0002248			Edwardsiella tarda infection 	MONDO:1014977		dysregulated	RT-qPCR; RNA-seq	novel_circ_0002248 is a DE-circRNA validated by RT-qPCR/Sanger sequencing and appears in predicted ceRNA modules (with novel_144 or novel_149) regulating nectin2 during Edwardsiella tarda infection in olive flounder intestine.	0.6521
31475036	Frontiers in genetics	2019	Identification of Potential Immune-Related circRNA-miRNA-mRNA Regulatory Network in Intestine of Paralichthys olivaceus During Edwardsiella tarda Infection.		novel_circ_0005065			Edwardsiella tarda infection 	MONDO:1014977		dysregulated	RNA-seq	"novel_circ_0005065 is consistently differentially expressed across all post-infection time comparisons and is a key circRNA node in predicted ceRNA modules (e.g., with novel_171 or pol-miR-144-5p; also with novel_149 targeting nectin2) during Edwardsiella tarda infection in olive flounder intestine."	0.4535
31475771	EMBO molecular medicine	2019	A circRNA signature predicts postoperative recurrence in stage II/III colon cancer.	hsa_circ_0122319		hsa_circ_PLOD2	PLOD2	stage II/III colon cancer	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0122319 is overexpressed in recurrent stage II/III colon cancer and in colon cancer cell lines. Its knockdown suppresses colon cancer cell migration, supporting a pro-metastatic role; it also contributes to a four-circRNA cirScore that predicts recurrence risk and worse survival when high."	0.8004
31475771	EMBO molecular medicine	2019	A circRNA signature predicts postoperative recurrence in stage II/III colon cancer.	hsa_circ_0087391		hsa_circ_AGTPBP1	AGTPBP1	stage II/III colon cancer	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0087391 is overexpressed in recurrent stage II/III colon cancer and colon cancer cells. Its knockdown reduces cell migration in vitro, and it is part of a four-circRNA prognostic cirScore associated with worse survival when high."	0.8004
31475771	EMBO molecular medicine	2019	A circRNA signature predicts postoperative recurrence in stage II/III colon cancer.	hsa_circ_0079480		hsa_circ_ISPD	ISPD	stage II/III colon cancer	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0079480 is overexpressed in recurrent stage II/III colon cancer and promotes metastatic behaviors. Knockdown suppresses migration in vitro and reduces liver and lung metastasis in nude mouse xenograft models; it is also part of a four-circRNA cirScore associated with worse survival when high.	0.8197
31475771	EMBO molecular medicine	2019	A circRNA signature predicts postoperative recurrence in stage II/III colon cancer.	hsa_circ_0008039		hsa_circ_PRKAR1B	PRKAR1B	stage II/III colon cancer	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0008039 is one of four circRNAs forming a prognostic cirScore for stage II/III colon cancer; higher cirScore predicts worse DFS/OS and higher recurrence risk. The study validates its circularity and expression for use in the classifier, but does not report a dedicated functional mechanism for this circRNA."	0.7278
31479922	Molecular therapy. Nucleic acids	2019	Circular RNA Cdr1as Upregulates SCAI to Suppress Cisplatin Resistance in Ovarian Cancer via miR-1270 Suppression.			hsa_circ_CDR1	CDR1	ovarian cancer	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR; Microarray	"Cdr1as is down-regulated in cisplatin-resistant ovarian cancer tissues/cells and in serum exosomes from cisplatin-resistant patients. Functionally, Cdr1as increases cisplatin chemosensitivity by acting as a ceRNA sponge for miR-1270, thereby restoring SCAI expression to inhibit malignant phenotypes and reduce cisplatin resistance."	0.7756
31480381	Biomolecules	2019	The Role of Circular RNA CDR1as/ciRS-7 in Regulating Tumor Microenvironment: A Pan-Cancer Analysis.			hsa_circ_CDR1AS	CDR1AS	cancer 	MONDO:0004992	cancer	dysregulated	RNA-seq	"This pan-cancer bioinformatics study reports that CDR1as is aberrantly expressed across human cancers and is higher in metastasis sites than primary sites. Enrichment and ceRNA-network analyses suggest CDR1as may modulate the tumor microenvironment by sponging multiple miRNAs (including miR-7-5p and miR-1299) and influencing genes involved in TGF-beta signaling and ECM-receptor interaction, which correlates with altered immune/stromal infiltration."	0.1768
31481066	Molecular cancer	2019	Circular RNA circ-ZKSCAN1 inhibits bladder cancer progression through miR-1178-3p/p21 axis and acts as a prognostic factor of recurrence.	hsa_circ_0001727		hsa_circ_ZKSCAN1	ZKSCAN1	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR	"circ-ZKSCAN1 is down-regulated in bladder cancer and acts as a tumor suppressor. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-1178-3p, thereby increasing p21 (CDKN1A) and inhibiting proliferation, migration, invasion, and metastasis. Low circ-ZKSCAN1 expression is associated with recurrence and worse survival outcomes."	0.8191
31484581	Molecular cancer	2019	RNA-Seq profiling of circular RNA in human lung adenocarcinoma and squamous cell carcinoma.	hsa_circ_0077837				non-small cell lung cancer	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0077837 is down-regulated in both LUAD and LUSC tumor tissues compared with adjacent normal tissues. It shows strong diagnostic performance for distinguishing NSCLC tumors from normal tissues by ROC analysis.	0.6605
31484581	Molecular cancer	2019	RNA-Seq profiling of circular RNA in human lung adenocarcinoma and squamous cell carcinoma.	hsa_circ_0001821		hsa_circ_PVT1	PVT1	non-small cell lung cancer	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0001821 (circPVT1) is up-regulated in both LUAD and LUSC tumor tissues compared with adjacent normal tissues. It has diagnostic potential for NSCLC by ROC analysis and is suggested to potentially promote NSCLC progression.	0.6605
31484581	Molecular cancer	2019	RNA-Seq profiling of circular RNA in human lung adenocarcinoma and squamous cell carcinoma.	hsa_circ_0077837				lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0077837 is down-regulated in both LUAD and LUSC tumor tissues compared with adjacent normal tissues. It shows strong diagnostic performance for distinguishing NSCLC tumors from normal tissues by ROC analysis.	0.6605
31484581	Molecular cancer	2019	RNA-Seq profiling of circular RNA in human lung adenocarcinoma and squamous cell carcinoma.	hsa_circ_0001821		hsa_circ_PVT1	PVT1	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0001821 (circPVT1) is up-regulated in both LUAD and LUSC tumor tissues compared with adjacent normal tissues. It has diagnostic potential for NSCLC by ROC analysis and is suggested to potentially promote NSCLC progression.	0.6605
31484581	Molecular cancer	2019	RNA-Seq profiling of circular RNA in human lung adenocarcinoma and squamous cell carcinoma.	hsa_circ_0077837				lung squamous cell carcinoma	MONDO:0005097	squamous cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0077837 is down-regulated in both LUAD and LUSC tumor tissues compared with adjacent normal tissues. It shows strong diagnostic performance for distinguishing NSCLC tumors from normal tissues by ROC analysis.	0.6605
31484581	Molecular cancer	2019	RNA-Seq profiling of circular RNA in human lung adenocarcinoma and squamous cell carcinoma.	hsa_circ_0001821		hsa_circ_PVT1	PVT1	lung squamous cell carcinoma	MONDO:0005097	squamous cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0001821 (circPVT1) is up-regulated in both LUAD and LUSC tumor tissues compared with adjacent normal tissues. It has diagnostic potential for NSCLC by ROC analysis and is suggested to potentially promote NSCLC progression.	0.6605
31484581	Molecular cancer	2019	RNA-Seq profiling of circular RNA in human lung adenocarcinoma and squamous cell carcinoma.	hsa_circ_0001073				lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0001073 is specifically down-regulated in LUAD (not LUSC) and shows high diagnostic accuracy for LUAD by ROC analysis.	0.5909
31484581	Molecular cancer	2019	RNA-Seq profiling of circular RNA in human lung adenocarcinoma and squamous cell carcinoma.	hsa_circ_0001495				lung squamous cell carcinoma 	MONDO:0005097	squamous cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0001495 is specifically up-regulated in LUSC (not LUAD) and shows high diagnostic accuracy for LUSC by ROC analysis.	0.5909
31484581	Molecular cancer	2019	RNA-Seq profiling of circular RNA in human lung adenocarcinoma and squamous cell carcinoma.	hsa_circ_0002360				lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0002360 is up-regulated in LUAD tumor tissues compared with adjacent normal tissues and was validated by qPCR and Sanger sequencing in this study.	0.3401
31485648	Molecular medicine reports	2019	Overexpressed circPVT1 in oral squamous cell carcinoma promotes proliferation by serving as a miRNA sponge.	hsa_circ_0001821		hsa_circ_PVT1	PVT1	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circPVT1 is up-regulated in OSCC tissues and cell lines and promotes OSCC cell proliferation. It mainly localizes in the cytoplasm and functions as a ceRNA by sponging miR-125b, thereby increasing STAT3 expression and driving proliferative phenotypes."	0.7845
31488193	Journal of experimental & clinical cancer research : CR	2019	"Knockdown of circDENND4C inhibits glycolysis, migration and invasion by up-regulating miR-200b/c in breast cancer under hypoxia."			hsa_circ_DENND4C	DENND4C	breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circDENND4C is up-regulated in breast cancer (and further induced by hypoxia) and promotes hypoxia-associated glycolysis, migration and invasion. Mechanistically, circDENND4C functions as a sponge for miR-200b and miR-200c; inhibiting circDENND4C increases miR-200b/c and suppresses tumor cell aggressiveness and xenograft growth."	0.7369
31496723	OncoTargets and therapy	2019	"Circular RNA hsa_circ_0023404 promotes proliferation, migration and invasion in non-small cell lung cancer by regulating miR-217/ZEB1 axis."	hsa_circ_0023404				non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0023404 is upregulated in NSCLC tissues/cell lines and promotes NSCLC cell proliferation, migration and invasion. Mechanistically, it sponges miR-217 to upregulate ZEB1, influencing EMT-associated markers. High hsa_circ_0023404 expression is associated with shorter overall survival in NSCLC patients."	0.7618
31496737	OncoTargets and therapy	2019	"CircLMNB1 promotes colorectal cancer by regulating cell proliferation, apoptosis and epithelial-mesenchymal transition."	hsa_circ_0127801		hsa_circ_LMNB1	LMNB1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH	"circLMNB1 (hsa_circ_0127801, from LMNB1) is up-regulated in colorectal cancer tissues and CRC cell lines. Functional assays show that circLMNB1 promotes malignant phenotypes (proliferation, migration/invasion, EMT) and suppresses apoptosis, partly accompanied by changes in EMT/apoptosis-related proteins (E-cadherin, N-cadherin, MMP2/9, Bax, caspase-3). It is proposed as a potential diagnostic biomarker for CRC."	0.7099
31496798	Cancer management and research	2019	The role of circular RNA hsa_circ_0085616 in proliferation and migration of hepatocellular carcinoma cells.	hsa_circ_0085616		hsa_circ_ASAP1	ASAP1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"hsa_circ_0085616 is up-regulated in HCC tissues and cell lines. Functional assays show it promotes HCC cell proliferation, migration and invasion, inhibits apoptosis, and shifts the cell cycle toward S/G2, potentially by increasing beta-catenin, p-ERK and p-AKT and activating Wnt/beta-catenin, ERK and PI3K/AKT signaling."	0.5751
31506425	Cell death & disease	2019	High throughput circRNA sequencing analysis reveals novel insights into the mechanism of nitidine chloride against hepatocellular carcinoma.	hsa_circ_0088364		hsa_circ_MRRF	MRRF	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0088364 is upregulated in HCC cells versus normal hepatocytes and functionally promotes HCC cell migration while inhibiting NC-induced apoptosis. It was validated as differentially expressed in NC-treated vs untreated HCC xenograft tumors and is predicted to participate in a circRNA-miRNA-mRNA (ceRNA-like) regulatory network.	0.6111
31506425	Cell death & disease	2019	High throughput circRNA sequencing analysis reveals novel insights into the mechanism of nitidine chloride against hepatocellular carcinoma.	hsa_circ_0090049		hsa_circ_MBTPS2	MBTPS2	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0090049 is upregulated in HCC cells versus normal hepatocytes and promotes malignant phenotypes, including proliferation, G1-phase cell-cycle progression, and migration, while inhibiting NC-induced apoptosis. It was validated as differentially expressed in NC-treated vs untreated HCC xenograft tumors and is predicted to act within a circRNA-miRNA-mRNA (ceRNA-like) network."	0.6111
31510782	Cell transplantation	2019	A circular RNA derived from MMP9 facilitates oral squamous cell carcinoma metastasis through regulation of MMP9 mRNA stability.	hsa_circ_0001162		hsa_circ_MMP9	MMP9	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circ-MMP9 (hsa_circ_0001162), derived from MMP9, is upregulated in OSCC tissues and plasma and is associated with metastasis and poorer survival. It promotes OSCC migration/invasion and lung metastasis by binding AUF1 and sponging miR-149, thereby increasing MMP9 mRNA stability and MMP9 expression."	0.8766
31511040	Journal of experimental & clinical cancer research : CR	2019	circPTN sponges miR-145-5p/miR-330-5p to promote proliferation and stemness in glioma.	hsa_circ_0003949		hsa_circ_PTN	PTN	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circPTN (hsa_circ_0003949), derived from PTN, is up-regulated in glioma and mainly localized in the cytoplasm. It promotes glioma proliferation/cell-cycle progression and in vivo tumor growth by sponging miR-145-5p and miR-330-5p, relieving suppression of SOX9 and ITGA5, and it enhances glioma stem-cell self-renewal and stemness via miR-145-5p binding."	0.8632
31511520	Nature communications	2019	CircAnks1a in the spinal cord regulates hypersensitivity in a rodent model of neuropathic pain.			rno_circ_Anks1a	Anks1a	neuropathic pain	MONDO:0021667	neuralgia	up-regulated	RT-qPCR; RNA-seq	"circAnks1a is upregulated in spinal dorsal horn neurons after spinal nerve ligation and promotes neuropathic pain hypersensitivity. Mechanistically, it enhances YBX1 nuclear translocation via transportin-1 and facilitates YBX1-driven Vegfb transcription by binding the Vegfb promoter, while also sponging miR-324-3p to increase VEGFB translation."	0.8223
31515467	Medical science monitor : international medical journal of experimental and clinical research	2019	Homo Sapiens Circular RNA 0079993 (hsa_circ_0079993) of the POLR2J4 Gene Acts as an Oncogene in Colorectal Cancer Through the microRNA-203a-3p.1 and CREB1 Axis.	hsa_circ_0079993		hsa_circ_POLR2J4	POLR2J4	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"hsa_circ_0079993 (circ_0079993), derived from POLR2J4, is up-regulated in colorectal cancer and functions as an oncogenic circRNA that promotes CRC cell proliferation and xenograft tumor growth. Mechanistically, it acts as a ceRNA by sponging miR-203a-3p.1 to relieve repression of CREB1, and anti-miR-203a-3p.1 reverses the growth inhibition caused by circ_0079993 knockdown."	0.7618
31519156	BMC cancer	2019	"FBXW7 circular RNA regulates proliferation, migration and invasion of colorectal carcinoma through NEK2, mTOR, and PTEN signaling pathways in vitro and in vivo."			hsa_circ_FBXW7	FBXW7	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"circ-FBXW7 is down-regulated in CRC tissues and functions as a tumor suppressor. Its knockdown promotes CRC cell proliferation/migration/invasion and xenograft growth, while overexpression suppresses these phenotypes, accompanied by decreased NEK2 and mTOR and increased PTEN."	0.5442
31524256	Molecular medicine reports	2019	Abnormal expression of circRNA_089763 in the plasma exosomes of patients with post_operative cognitive dysfunction after coronary artery bypass grafting.		circRNA_089763			post-operative cognitive dysfunction 	MONDO:0002039	cognitive disorder	up-regulated	RT-qPCR; Microarray	"This study identified circRNA_089763 as significantly up-regulated in plasma exosomes of POCD patients after CABG (validated by RT-qPCR). Bioinformatic prediction suggests circRNA_089763 may act as a ceRNA to sponge multiple miRNAs and indirectly affect targets such as IGFBP5, STC-1 and YWHAG, implicating it as a potential POCD biomarker."	0.4032
31533620	BMC genomics	2019	High-throughput sequencing of circRNAs reveals novel insights into mechanisms of nigericin in pancreatic cancer.		circRNA_00412			pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"circRNA_00412 was experimentally validated by RT-qPCR as up-regulated in pancreatic cancer cell lines after 32 h nigericin treatment versus 0 h, serving as part of the nigericin-responsive circRNA expression profile."	0.385
31533620	BMC genomics	2019	High-throughput sequencing of circRNAs reveals novel insights into mechanisms of nigericin in pancreatic cancer.		circRNA_02785			pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"circRNA_02785 was validated by RT-qPCR as up-regulated in pancreatic cancer cell lines after 32 h nigericin treatment versus 0 h, indicating it is part of the nigericin-responsive circRNA signature."	0.385
31533620	BMC genomics	2019	High-throughput sequencing of circRNAs reveals novel insights into mechanisms of nigericin in pancreatic cancer.		circRNA_04818			pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"circRNA_04818 was confirmed by RT-qPCR to be up-regulated in pancreatic cancer cell lines after 32 h nigericin exposure, supporting its inclusion among nigericin-responsive circRNAs."	0.385
31533620	BMC genomics	2019	High-throughput sequencing of circRNAs reveals novel insights into mechanisms of nigericin in pancreatic cancer.		circRNA_08372			pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"circRNA_08372 was experimentally validated as up-regulated after nigericin exposure in pancreatic cancer cell lines, but no specific downstream mechanism was established beyond global bioinformatics predictions."	0.385
31533620	BMC genomics	2019	High-throughput sequencing of circRNAs reveals novel insights into mechanisms of nigericin in pancreatic cancer.		circRNA_14183			pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"circRNA_14183 was validated as significantly up-regulated after nigericin treatment in pancreatic cancer cell lines, but its specific targets and pathways were not experimentally established in this paper."	0.385
31533620	BMC genomics	2019	High-throughput sequencing of circRNAs reveals novel insights into mechanisms of nigericin in pancreatic cancer.		circRNA_00139			pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	down-regulated	RT-qPCR	"circRNA_00139 was validated by RT-qPCR to be down-regulated in pancreatic cancer cell lines after 32 h nigericin exposure versus 0 h, representing a nigericin-responsive circRNA."	0.385
31533620	BMC genomics	2019	High-throughput sequencing of circRNAs reveals novel insights into mechanisms of nigericin in pancreatic cancer.		circRNA_00752			pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	down-regulated	RT-qPCR	"circRNA_00752 showed significant down-regulation after nigericin treatment in pancreatic cancer cell lines based on RT-qPCR validation, with no specific mechanistic axis experimentally confirmed."	0.385
31533620	BMC genomics	2019	High-throughput sequencing of circRNAs reveals novel insights into mechanisms of nigericin in pancreatic cancer.		circRNA_03061			pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	down-regulated	RT-qPCR	"circRNA_03061 was experimentally validated as down-regulated in pancreatic cancer cell lines following nigericin exposure, without a directly tested functional mechanism for this circRNA."	0.385
31533620	BMC genomics	2019	High-throughput sequencing of circRNAs reveals novel insights into mechanisms of nigericin in pancreatic cancer.		circRNA_07721			pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	down-regulated	RT-qPCR	"circRNA_07721 was confirmed by RT-qPCR to be down-regulated following nigericin treatment in pancreatic cancer cell lines, as part of sequencing-data validation."	0.385
31533620	BMC genomics	2019	High-throughput sequencing of circRNAs reveals novel insights into mechanisms of nigericin in pancreatic cancer.		circRNA_17369			pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	down-regulated	RT-qPCR	"circRNA_17369 was validated by RT-qPCR as down-regulated after 32 h nigericin treatment in pancreatic cancer cell lines, supporting sequencing-derived differential expression."	0.385
31533653	BMC cancer	2019	Circ-Foxo3 is positively associated with the Foxo3 gene and leads to better prognosis of acute myeloid leukemia patients.			hsa_circ_Foxo3	Foxo3	acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	down-regulated	RT-qPCR	"circ-Foxo3 is down-regulated in de novo AML bone marrow samples compared with controls. It shows diagnostic potential by ROC analysis, while its association with overall survival is not statistically significant in this cohort; higher circ-Foxo3 shows a non-significant trend toward longer survival. The paper discusses a possible relationship with the host gene Foxo3 and a speculative miRNA-related mechanism, but miRNA partners were not identified in this study."	0.5121
31533844	Molecular brain	2019	Circular RNA expression profile in the spinal cord of morphine tolerated rats and screen of putative key circRNAs.		rno_circRNA_005151	rno_circ_WHSC1	WHSC1	morphine tolerance	MONDO:0005531	morphine dependence	down-regulated	RT-qPCR; Microarray	rno_circRNA_005151 (circ_005151) is down-regulated in the lumbar spinal cord of morphine-tolerant rats. It was among the validated circRNAs and was included in predicted circRNA_miRNA_mRNA and ceRNA network analyses as a candidate regulator in morphine tolerance.	0.4997
31533844	Molecular brain	2019	Circular RNA expression profile in the spinal cord of morphine tolerated rats and screen of putative key circRNAs.		rno_circRNA_010774			morphine tolerance	MONDO:0005531	morphine dependence	down-regulated	RT-qPCR; Microarray	rno_circRNA_010774 is down-regulated in the spinal cord of morphine-tolerant rats and was one of the validated circRNAs chosen for bioinformatically predicted circRNA_miRNA_mRNA and ceRNA network analyses.	0.4997
31533844	Molecular brain	2019	Circular RNA expression profile in the spinal cord of morphine tolerated rats and screen of putative key circRNAs.		rno_circRNA_014599			morphine tolerance	MONDO:0005531	morphine dependence	down-regulated	RT-qPCR; Microarray	rno_circRNA_014599 is down-regulated in the spinal cord of morphine-tolerant rats and was among the circRNAs whose differential expression was validated by RT-qPCR.	0.4625
31533844	Molecular brain	2019	Circular RNA expression profile in the spinal cord of morphine tolerated rats and screen of putative key circRNAs.		rno_circRNA_012605			morphine tolerance	MONDO:0005531	morphine dependence	down-regulated	RT-qPCR; Microarray	rno_ circRNA_012605 is down-regulated in the spinal cord of morphine-tolerant rats and was among the circRNAs whose differential expression was validated by RT-qPCR.	0.4625
31533844	Molecular brain	2019	Circular RNA expression profile in the spinal cord of morphine tolerated rats and screen of putative key circRNAs.		rno_circRNA_017999			morphine tolerance	MONDO:0005531	morphine dependence	down-regulated	RT-qPCR; Microarray	rno_circRNA_017999 is down-regulated in the spinal cord of morphine-tolerant rats and was among the circRNAs whose differential expression was validated by RT-qPCR.	0.4625
31533844	Molecular brain	2019	Circular RNA expression profile in the spinal cord of morphine tolerated rats and screen of putative key circRNAs.		rno_circRNA_008508			morphine tolerance	MONDO:0005531	morphine dependence	up-regulated	RT-qPCR; Microarray	"circRNA_008508 is up-regulated in morphine-tolerant rat spinal cord. The study¡¯s ceRNA analysis suggests it may interact with miR-181 family and affect TLR-4-related neuroinflammation, potentially promoting morphine tolerance (prediction/hypothesis)."	0.4997
31533844	Molecular brain	2019	Circular RNA expression profile in the spinal cord of morphine tolerated rats and screen of putative key circRNAs.		rno_circRNA_000047			morphine tolerance	MONDO:0005531	morphine dependence	up-regulated	RT-qPCR; Microarray	rno_circRNA_000047 is up-regulated in the spinal cord of morphine-tolerant rats and was among the circRNAs whose differential expression was validated by RT-qPCR.	0.4625
31535687	Carcinogenesis	2020	Plasma hsa_circ_0027089 is a diagnostic biomarker for hepatitis B virus-related hepatocellular carcinoma.	hsa_circ_0027089		hsa_circ_PTGES3	PTGES3	hepatitis B virus (HBV)-related hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"Plasma hsa_circ_0027089 is significantly up-regulated in HBV-related HCC and can distinguish HCC patients from HBV-related cirrhosis and healthy controls, showing diagnostic performance comparable to AFP. The study reports its genomic origin from PTGES3 and provides predicted miRNA binding partners, but does not experimentally validate a functional mechanism."	0.6556
31536884	Molecular therapy. Nucleic acids	2019	circFBXW7 Inhibits Malignant Progression by Sponging miR-197-3p and Encoding a 185-aa Protein in Triple-Negative Breast Cancer.	hsa_circ_0001451	circFBXW7	hsa_circ_FBXW7	FBXW7	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	down-regulated	RT-qPCR	"circFBXW7 is down-regulated in TNBC and functions as a tumor suppressor by inhibiting proliferation, migration, tumor growth and metastasis. Mechanistically, it sponges miR-197-3p to de-repress FBXW7 (ceRNA effect) and also encodes the FBXW7-185aa protein, which increases FBXW7 abundance and promotes c-Myc degradation. Clinically, low circFBXW7 is associated with poorer survival and adverse clinicopathologic features."	0.783
31541092	Nature communications	2019	Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis.		circFndc3b	hsa_circ_FNDC3B	Fndc3b	myocardial infarction 	MONDO:0005068	myocardial infarction	down-regulated	RT-qPCR; Microarray	"circFndc3b is down-regulated after MI (mouse hearts) and in ischemic cardiomyopathy (human LV). Restoring circFndc3b expression protects the post-MI heart by reducing apoptosis and promoting neovascularization, largely through binding the RBP FUS and increasing VEGF-A signaling rather than via miRNA sponging."	0.7768
31541092	Nature communications	2019	Circular RNA CircFndc3b modulates cardiac repair after myocardial infarction via FUS/VEGF-A axis.		circFndc3b	mmu_circ_Fndc3b	Fndc3b	myocardial infarction 	MONDO:0005068	myocardial infarction	down-regulated	RT-qPCR; Microarray	"circFndc3b is down-regulated after MI (mouse hearts) and in ischemic cardiomyopathy (human LV). Restoring circFndc3b expression protects the post-MI heart by reducing apoptosis and promoting neovascularization, largely through binding the RBP FUS and increasing VEGF-A signaling rather than via miRNA sponging."	0.7768
31545426	Molecular medicine reports	2019	Comprehensive expression profiles and bioinformatics analysis reveal special circular RNA expression and potential predictability in the peripheral blood of humans with idiopathic membranous nephropathy.		hsa_circ_101319	hsa_circ_RBM23	RBM23	idiopathic membranous nephropathy 	MONDO:0005376	membranous glomerulonephritis	up-regulated	RT-qPCR; Microarray	"circ_101319 (hsa_circ_101319, derived from RBM23) is significantly upregulated in peripheral blood of IMN patients and shows good diagnostic performance (AUROC 0.89). Bioinformatics analyses predict it may act through a circRNA_miRNA_mRNA ceRNA network, prominently involving miR-135 family members."	0.6556
31545480	International journal of molecular medicine	2019	Comprehensive circular RNA profiling reveals the regulatory role of the hsa_circ_0137606/miR_1231 pathway in bladder cancer progression.	hsa_circ_0137606		hsa_circ_NIPSNAP3A	NIPSNAP3A	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0137606 is significantly downregulated in bladder cancer and acts as a tumor-suppressive circRNA. It inhibits BC cell proliferation, migration and invasion by sponging miR-1231, with PHLPP2 predicted as a downstream target of the hsa_circ_0137606/miR-1231 axis."	0.6676
31551242	Biology open	2019	The circular RNA PVT1/miR-203/HOXD3 pathway promotes the progression of human hepatocellular carcinoma.			hsa_circ_PVT1		hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circPVT1 is up-regulated in HCC tissues and cell lines and is associated with poor prognosis. It promotes HCC cell proliferation, cell-cycle progression and migration, and enhances xenograft tumor growth by sponging miR-203 to increase HOXD3 expression."	0.7412
31552107	Frontiers in genetics	2019	CeRNA Expression Profiling Identifies KIT-Related circRNA-miRNA-mRNA Networks in Gastrointestinal Stromal Tumour.	hsa_circ_0069765		hsa_circ_KIT	KIT	gastrointestinal stromal tumours 	MONDO:0011719	gastrointestinal stromal tumor	up-regulated	RT-qPCR; Microarray	"circ_0069765 is up-regulated in GIST tissues and is part of a predicted circRNA_miRNA_host gene (KIT-related) regulatory network involving miR-142-5p/miR-144-3p/miR-485-3p and other predicted miRNAs. The study proposes it may serve as a biomarker/therapeutic target, but does not experimentally validate downstream functional effects."	0.6193
31552107	Frontiers in genetics	2019	CeRNA Expression Profiling Identifies KIT-Related circRNA-miRNA-mRNA Networks in Gastrointestinal Stromal Tumour.	hsa_circ_0084097		hsa_circ_PLAT	PLAT	gastrointestinal stromal tumours 	MONDO:0011719	gastrointestinal stromal tumor	up-regulated	RT-qPCR; Microarray	"circ_0084097 is up-regulated in GIST tissues and is included in a predicted circRNA_miRNA_mRNA network with KIT/PLAT/ETV1 and multiple miRNAs. Clinically, higher circ_0084097 (and PLAT) is negatively correlated with metastasis in stomach-related tumors, suggesting association with earlier-stage disease."	0.6809
31552107	Frontiers in genetics	2019	CeRNA Expression Profiling Identifies KIT-Related circRNA-miRNA-mRNA Networks in Gastrointestinal Stromal Tumour.	hsa_circ_0079471		hsa_circ_ETV1	ETV1	gastrointestinal stromal tumours 	MONDO:0011719	gastrointestinal stromal tumor	up-regulated	RT-qPCR; Microarray	circ_0079471 is up-regulated in GIST tissues and is part of a predicted circRNA_miRNA_mRNA network centered on KIT/PLAT/ETV1 and multiple miRNAs. The study suggests its oncogenic relevance via ceRNA interactions but does not provide direct functional assays for circ_0079471 itself.	0.6193
31555374	Experimental and therapeutic medicine	2019	Microarray expression and functional analysis of circular RNAs in the glomeruli of NZB/W F1 mice with lupus nephritis.		mmu_circRNA_27407	mmu_circ_Sh3bp5	Sh3bp5	lupus nephritis 	MONDO:0005556	lupus nephritis	up-regulated	RT-qPCR; Microarray	mmu_circRNA_27407 (host gene Sh3bp5) is significantly up-regulated in glomeruli from severe lupus nephritis NZB/W F1 mice compared with mild LN. The study reports it as a validated differentially expressed circRNA but does not further characterize its mechanism or function.	0.4032
31555374	Experimental and therapeutic medicine	2019	Microarray expression and functional analysis of circular RNAs in the glomeruli of NZB/W F1 mice with lupus nephritis.		mmu_circRNA_34428	mmu_circ_Pdia3	Pdia3	lupus nephritis 	MONDO:0005556	lupus nephritis	up-regulated	RT-qPCR; Microarray	"mmu_circRNA_34428 (host gene Pdia3) is significantly up-regulated in glomeruli from severe versus mild lupus nephritis NZB/W F1 mice. The study constructs a predicted ceRNA network where mmu_circRNA_34428 may sponge mmu-miR-34b-5p, mmu-miR-670-3p, mmu-miR-338-3p and mmu-miR-3066-3p to influence downstream mRNAs, and suggests diagnostic biomarker potential for LN."	0.5135
31555374	Experimental and therapeutic medicine	2019	Microarray expression and functional analysis of circular RNAs in the glomeruli of NZB/W F1 mice with lupus nephritis.		mmu_circRNA_45029	mmu_circ_Wdr82	Wdr82	lupus nephritis 	MONDO:0005556	lupus nephritis	up-regulated	RT-qPCR; Microarray	"mmu_circRNA_45029 (host gene Wdr82) is reported as an up-regulated circRNA in severe versus mild LN glomeruli and was included among key circRNAs used to construct a ceRNA network, but no specific mechanism or function for this circRNA is detailed."	0.5135
31555374	Experimental and therapeutic medicine	2019	Microarray expression and functional analysis of circular RNAs in the glomeruli of NZB/W F1 mice with lupus nephritis.		mmu_circRNA_010964			lupus nephritis 	MONDO:0005556	lupus nephritis	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_010964 is reported as a down-regulated circRNA in severe versus mild LN glomeruli and was included among key circRNAs used for ceRNA-network prediction, but no specific mechanism or function is described."	0.5135
31555374	Experimental and therapeutic medicine	2019	Microarray expression and functional analysis of circular RNAs in the glomeruli of NZB/W F1 mice with lupus nephritis.		mmu_circRNA_014199	mmu_circ_Mamdc4	Mamdc4	lupus nephritis 	MONDO:0005556	lupus nephritis	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_014199 (host gene Mamdc4) is reported as down-regulated in severe versus mild LN glomeruli and was included among key circRNAs used for ceRNA-network construction, but no circRNA-specific function or mechanism is further provided."	0.5135
31555374	Experimental and therapeutic medicine	2019	Microarray expression and functional analysis of circular RNAs in the glomeruli of NZB/W F1 mice with lupus nephritis.		mmu_circRNA_19429	mmu_circ_Plxnd1	Plxnd1	lupus nephritis 	MONDO:0005556	lupus nephritis	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_19429 (host gene Plxnd1) is reported as down-regulated in severe versus mild LN glomeruli and was included in the ceRNA-network construction set, but no circRNA-specific mechanism or functional validation is provided."	0.5135
31555374	Experimental and therapeutic medicine	2019	Microarray expression and functional analysis of circular RNAs in the glomeruli of NZB/W F1 mice with lupus nephritis.		mmu_circRNA_19677			lupus nephritis 	MONDO:0005556	lupus nephritis	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_19677 is reported as down-regulated in severe versus mild LN glomeruli and was RT-qPCR-validated as consistent with microarray, but no host gene/mechanism/function is described in the provided text."	0.4773
31555374	Experimental and therapeutic medicine	2019	Microarray expression and functional analysis of circular RNAs in the glomeruli of NZB/W F1 mice with lupus nephritis.		mmu_circRNA_33250	mmu_circ_Tbc1d13	Tbc1d13	lupus nephritis 	MONDO:0005556	lupus nephritis	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_33250 (host gene Tbc1d13) is reported as down-regulated in severe versus mild LN glomeruli and was RT-qPCR-validated as consistent with microarray, but no further functional/mechanistic characterization is provided."	0.4773
31558874	World journal of gastroenterology	2019	Circular RNA PIP5K1A promotes colon cancer development through inhibiting miR-1273a.	hsa_circ_0014130		hsa_circ_PIP5K1A	PIP5K1A	colon cancer	MONDO:0021063	malignant colon neoplasm	up-regulated	RT-qPCR	"circPIP5K1A (hsa_circ_0014130, host gene PIP5K1A) is up-regulated in colon cancer tissues and cancer cell lines. Functionally, it promotes cell viability and enhances invasion/migration while its knockdown increases cell death. Mechanistically, it antagonizes miR-1273a and is linked to regulation of AP-1, IRF-4, CDX-2 and Zic-1 expression."	0.6479
31561125	Molecular therapy. Nucleic acids	2019	"Crosstalk of mRNA, miRNA, lncRNA, and circRNA and Their Regulatory Pattern in Pulmonary Fibrosis."		circ949 / circRNA14:30346797-30350949	mmu_circ_CACNA1D	CACNA1D	pulmonary fibrosis 	MONDO:0002771	pulmonary fibrosis	up-regulated	RT-qPCR; RNA-seq	"In bleomycin-induced mouse pulmonary fibrosis, circ949 is up-regulated and predominantly localized in the cytoplasm. It directly binds miR-29b-2-5p and participates in an ncRNA regulatory network that modulates STAT3 phosphorylation to promote fibrotic progression."	0.7753
31561125	Molecular therapy. Nucleic acids	2019	"Crosstalk of mRNA, miRNA, lncRNA, and circRNA and Their Regulatory Pattern in Pulmonary Fibrosis."		circ057 / 6:99003199-99100057	mmu_circ_FOXP1	FOXP1	pulmonary fibrosis 	MONDO:0002771	pulmonary fibrosis	up-regulated	RT-qPCR; RNA-seq	"In bleomycin-induced mouse pulmonary fibrosis, circ057 is up-regulated and predominantly localized in the cytoplasm. It directly binds miR-29b-2-5p and participates in an ncRNA regulatory network that modulates STAT3 phosphorylation to promote fibrotic progression."	0.7753
31561126	Molecular therapy. Nucleic acids	2019	Upregulated circRNA ARHGAP10 Predicts an Unfavorable Prognosis in NSCLC through Regulation of the miR-150-5p/GLUT-1 Axis.	hsa_circ_0008975		hsa_circ_ARHGAP10	ARHGAP10	non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circARHGAP10 (hsa_circ_0008975), derived from ARHGAP10, is upregulated in NSCLC tissues and cell lines and is mainly localized in the cytoplasm. It promotes NSCLC cell proliferation, glycolytic metabolism, EMT-associated metastasis by sponging miR-150-5p to increase GLUT1, and high expression is associated with poor overall survival."	0.8155
31561126	Molecular therapy. Nucleic acids	2019	Upregulated circRNA ARHGAP10 Predicts an Unfavorable Prognosis in NSCLC through Regulation of the miR-150-5p/GLUT-1 Axis.	hsa_circ_0001421				non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001421 was identified by RNA-seq and validated by RT-qPCR as upregulated in NSCLC tissues compared with matched adjacent non-tumor tissues, but no functional mechanism was investigated further in this study."	0.3588
31561126	Molecular therapy. Nucleic acids	2019	Upregulated circRNA ARHGAP10 Predicts an Unfavorable Prognosis in NSCLC through Regulation of the miR-150-5p/GLUT-1 Axis.	hsa_circ_0008133				non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0008133 was identified by RNA-seq and validated by RT-qPCR as upregulated in NSCLC tissues compared with matched adjacent non-tumor tissues, but it was not further mechanistically characterized."	0.3588
31561126	Molecular therapy. Nucleic acids	2019	Upregulated circRNA ARHGAP10 Predicts an Unfavorable Prognosis in NSCLC through Regulation of the miR-150-5p/GLUT-1 Axis.	hsa_circ_0000042				non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000042 was screened by RNA-seq and experimentally confirmed by RT-qPCR to be upregulated in NSCLC tissues, but was not studied further for function or mechanism."	0.3588
31561126	Molecular therapy. Nucleic acids	2019	Upregulated circRNA ARHGAP10 Predicts an Unfavorable Prognosis in NSCLC through Regulation of the miR-150-5p/GLUT-1 Axis.	hsa_circ_0005082				non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005082 was selected from RNA-seq results and validated by RT-qPCR as upregulated in NSCLC tissues versus matched adjacent non-tumor tissues, without further functional or mechanistic characterization in this paper."	0.3588
31564891	OncoTargets and therapy	2019	"Circular RNA SMARCA5 inhibits the proliferation, migration, and invasion of non-small cell lung cancer by miR-19b-3p/HOXA9 axis."			hsa_circ_SMARCA5	SMARCA5	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"circSMARCA5 is down-regulated in NSCLC tissues and cell lines and functions as a tumor suppressor. Its overexpression inhibits NSCLC cell proliferation, migration, and invasion and suppresses xenograft tumor growth, mainly by sponging miR-19b-3p to regulate HOXA9."	0.6479
31565098	Disease markers	2019	Circular RNA hsa_circ_0006848 Related to Ribosomal Protein L6 Acts as a Novel Biomarker for Early Gastric Cancer.	hsa_circ_0006848		hsa_circ_FOXJ3	FOXJ3	early gastric cancer 	MONDO:0004950	gastric carcinoma	down-regulated	RT-qPCR	"hsa_circ_0006848 is down-regulated in EGC tissues and in patient plasma, and its plasma level increases after surgery, supporting its role as a noninvasive diagnostic biomarker for EGC. A predicted ceRNA axis (hsa_circ_0006848/hsa_miR-329-5p/RPL6) was proposed by bioinformatics analysis."	0.459
31573758	Molecular genetics & genomic medicine	2019	Circular RNA circ-TSPAN4 promotes lung adenocarcinoma metastasis by upregulating ZEB1 via sponging miR-665.	hsa_circ_0020732		hsa_circ_TSPAN4	TSPAN4	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circ-TSPAN4 (hsa_circ_0020732) is up-regulated in LUAD and promotes migration/invasion and in vivo lung metastasis. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-665 to increase ZEB1, linking high circ-TSPAN4 to metastatic features and poor survival."	0.8066
31575051	Cancers	2019	"Circular RNAs in Clear Cell Renal Cell Carcinoma: Their Microarray-Based Identification, Analytical Validation, and Potential Use in a Clinico-Genomic Model to Improve Prognostic Accuracy."	hsa_circ_0101692	circRNA_405198	hsa_circ_EGLN3	EGLN3	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR; Microarray	CircEGLN3 is up-regulated in ccRCC tumor tissue versus adjacent normal tissue and can discriminate tumor from normal with very high accuracy. Higher circEGLN3 expression is associated with better survival outcomes and it is part of a multivariable RNA signature that improves prognostic models when combined with clinicopathological factors.	0.7278
31575051	Cancers	2019	"Circular RNAs in Clear Cell Renal Cell Carcinoma: Their Microarray-Based Identification, Analytical Validation, and Potential Use in a Clinico-Genomic Model to Improve Prognostic Accuracy."	hsa_circ_0023984	circRNA_100933	hsa_circ_NOX4	NOX4	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	down-regulated	RT-qPCR; Microarray	"CircNOX4 is down-regulated in ccRCC tumor tissue versus adjacent normal tissue and shows diagnostic discrimination by ROC analysis. However, its expression is not associated with cancer-specific survival in this cohort."	0.7278
31575051	Cancers	2019	"Circular RNAs in Clear Cell Renal Cell Carcinoma: Their Microarray-Based Identification, Analytical Validation, and Potential Use in a Clinico-Genomic Model to Improve Prognostic Accuracy."	hsa_circ_0007444		hsa_circ_RHOBTB3	RHOBTB3	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	down-regulated	RT-qPCR; Microarray	"CircRHOBTB3 is down-regulated in ccRCC tumor tissue versus adjacent normal tissue. Higher circRHOBTB3 expression predicts better survival and it remains in multivariate prognostic RNA signatures; mechanistically, in-silico analysis suggests a possible circRHOBTB3/miR-494/PTEN ceRNA link, but this was not experimentally validated."	0.7278
31579577	PeerJ	2019	Identification and characterization of circRNAs as competing endogenous RNAs for miRNA-mRNA in colorectal cancer.			hsa_circ_PIEZO1	PIEZO1	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RNA-seq	circPIEZO1-3 is one of the top down-regulated circRNAs in colorectal cancer tissues. The study includes it as a hub circRNA in a bioinformatically constructed ceRNA (circRNA-miRNA-mRNA) network potentially involved in CRC carcinogenesis.	0.4685
31579577	PeerJ	2019	Identification and characterization of circRNAs as competing endogenous RNAs for miRNA-mRNA in colorectal cancer.	hsa_circ_0067163				colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RNA-seq	hsa_circ_0067163 is down-regulated in colorectal cancer and is included as a hub circRNA in the study¡¯s ceRNA network. The paper describes it as a sponge of hsa-miR-424-5p with downstream association to TPM2 in the constructed circRNA-miRNA-mRNA network.	0.4685
31579577	PeerJ	2019	Identification and characterization of circRNAs as competing endogenous RNAs for miRNA-mRNA in colorectal cancer.	hsa_circ_0140188		hsa_circ_DMD	DMD	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RNA-seq	"hsa_circ_0140188 is significantly down-regulated in colorectal cancer tissues and originates from the host gene DMD, whose expression is also decreased. It is one of the hub circRNAs used to construct a CRC ceRNA network in this study."	0.4685
31579577	PeerJ	2019	Identification and characterization of circRNAs as competing endogenous RNAs for miRNA-mRNA in colorectal cancer.	hsa_circ_0002632				colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RNA-seq	hsa_circ_0002632 is one of the top up-regulated circRNAs in colorectal cancer tissues. The study treats it as a hub circRNA to build a predicted circRNA-miRNA-mRNA ceRNA network relevant to CRC.	0.4685
31579577	PeerJ	2019	Identification and characterization of circRNAs as competing endogenous RNAs for miRNA-mRNA in colorectal cancer.	hsa_circ_0001998				colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RNA-seq	hsa_circ_0001998 is one of the top up-regulated circRNAs used to build the CRC ceRNA network. The paper describes it (together with hsa_circ_0067163) as associated with sponging hsa-miR-424-5p and linking to TPM2 in the predicted regulatory network.	0.4685
31579577	PeerJ	2019	Identification and characterization of circRNAs as competing endogenous RNAs for miRNA-mRNA in colorectal cancer.	hsa_circ_0023990		hsa_circ_NOX4	NOX4	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RNA-seq	"hsa_circ_0023990 is up-regulated in colorectal cancer and originates from NOX4. In the study¡¯s predicted ceRNA context, higher hsa_circ_0023990 expression is associated with longer survival time, linked to higher expression of SOX1, AQP6 and ITGBL1."	0.559
31581132	Aging	2019	CircRNA Cdr1as functions as a competitive endogenous RNA to promote hepatocellular carcinoma progression.	hsa_circ_0001946	CircRNA Cdr1as / Cdr1as	hsa_circ_CDR1	CDR1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"CircRNA Cdr1as is up-regulated in HCC tissues and cell lines and promotes proliferation, migration, tumor growth and lung metastasis. It mainly localizes to the cytoplasm and functions as a ceRNA that sponges miR-1270 to increase AFP expression. Cdr1as is enriched in exosomes and can be transferred to recipient cells, enhancing proliferative and migratory phenotypes."	0.8657
31582722	Cell death & disease	2019	CircERCC2 ameliorated intervertebral disc degeneration by regulating mitophagy and apoptosis through miR-182-5p/SIRT1 axis.	hsa_circ_0051470	circERCC2	hsa_circ_ERCC2	ERCC2	intervertebral disc degeneration 	MONDO:0011385	intervertebral disk degenerative disorder	down-regulated	RT-qPCR; ISH; Microarray	"circERCC2 (hsa_circ_0051470) is downregulated in IVDD nucleus pulposus tissues. Its overexpression sponges miR-182-5p to upregulate SIRT1, thereby promoting mitophagy and inhibiting apoptosis/ECM degradation in NPCs and alleviating IVDD in a rat needle-puncture model."	0.6181
31582727	Cell death & disease	2019	CircCDR1as upregulates autophagy under hypoxia to promote tumor cell survival via AKT/ERK_/mTOR signaling pathways in oral squamous cell carcinomas.		CircCDR1as	hsa_circ_CDR1AS		oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"CircCDR1as is up-regulated in OSCC tissues/cell lines and further induced by hypoxia. It promotes OSCC cell survival and tumor growth by enhancing autophagy under hypoxia via AKT/ERK activation and mTOR inhibition, and acts as a sponge for miR-671-5p. High circCDR1as expression is associated with shorter postoperative survival."	0.7408
31582895	Mediators of inflammation	2019	circRNA CDR1as Regulated the Proliferation of Human Periodontal Ligament Stem Cells under a Lipopolysaccharide-Induced Inflammatory Condition.			hsa_circ_CDR1AS		periodontitis 	MONDO:0005076	periodontitis	down-regulated	RT-qPCR	"CDR1as is down-regulated in periodontitis periodontal ligament tissues and in LPS-treated PDLSCs. Functionally, CDR1as promotes PDLSC proliferation and counteracts LPS-induced proliferative inhibition by sponging miR-7 and activating ERK signaling."	0.5546
31582908	Cancer cell international	2019	Circular RNA CDR1as sponges miR-7-5p to enhance E2F3 stability and promote the growth of nasopharyngeal carcinoma.			hsa_circ_CDR1	CDR1	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"CDR1as is up-regulated in NPC tissues and cell lines and promotes NPC growth and glycolytic metabolism. Mechanistically, CDR1as acts as a ceRNA sponge for miR-7-5p, thereby increasing E2F3 expression, which supports proliferation and tumor growth in xenografts."	0.7396
31584877	Aging	2019	CircUBAP2-mediated competing endogenous RNA network modulates tumorigenesis in pancreatic adenocarcinoma.	hsa_circ_0007367		hsa_circ_UBAP2	UBAP2	pancreatic adenocarcinoma 	MONDO:0006047	pancreatic adenocarcinoma	up-regulated	Microarray	"circ-UBAP2 (hsa_circ_0007367) is up-regulated in PAAD and is proposed to function in a ceRNA network by inhibiting hsa-miR-494, thereby increasing expression of hub genes such as CXCR4, HIF1A, ZEB1 and SDC1. The circUBAP2-mediated network is linked to immune-cell infiltration and immune escape features in PAAD."	0.1768
31584877	Aging	2019	CircUBAP2-mediated competing endogenous RNA network modulates tumorigenesis in pancreatic adenocarcinoma.	hsa_circ_0003958	circ-HIBADH	hsa_circ_HIBADH	HIBADH	pancreatic adenocarcinoma 	MONDO:0006047	pancreatic adenocarcinoma	down-regulated	Microarray	"circ-HIBADH (hsa_circ_0003958) is down-regulated in PAAD and is included in the constructed ceRNA network. The paper proposes a circ-HIBADH/hsa-miR-214 regulatory axis potentially involved in PAAD growth and progression, without experimental validation beyond expression/network analyses."	0.1768
31584877	Aging	2019	CircUBAP2-mediated competing endogenous RNA network modulates tumorigenesis in pancreatic adenocarcinoma.	hsa_circ_0043278	circ-TADA2A	hsa_circ_TADA2A	TADA2A	pancreatic adenocarcinoma 	MONDO:0006047	pancreatic adenocarcinoma	up-regulated	Microarray	"circ-TADA2A (hsa_circ_0043278) is up-regulated in PAAD and included in the constructed ceRNA network. The paper proposes a circ-TADA2A/hsa-miR-214 axis potentially involved in PAAD growth and progression, based on database-driven network analyses."	0.1768
31584877	Aging	2019	CircUBAP2-mediated competing endogenous RNA network modulates tumorigenesis in pancreatic adenocarcinoma.	hsa_circ_0049783		hsa_circ_CLEC17A	CLEC17A	pancreatic adenocarcinoma 	MONDO:0006047	pancreatic adenocarcinoma	up-regulated	Microarray	"circ-CLEC17A (hsa_circ_0049783) is up-regulated in PAAD and included in the constructed ceRNA network, with a proposed circ-CLEC17A/hsa-mir-324-3p axis. It also shows higher expression in female PAAD tissues than in males in the analyzed dataset."	0.1768
31591557	Nature neuroscience	2019	An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations.		circHOMER1	hsa_circ_HOMER1	HOMER1	Alzheimer disease 	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR; RNA-seq	circHOMER1 is down-regulated with increasing AD clinical severity and is significantly associated with AD diagnosis and neuropathological severity. The study suggests circHOMER1 may be functionally relevant via predicted miRNA binding (miR-651) and co-expression with oxidative phosphorylation/AD-related genes.	0.5135
31591557	Nature neuroscience	2019	An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations.		circKCNN2	hsa_circ_KCNN2	KCNN2	Alzheimer disease 	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR; RNA-seq	"circKCNN2 is consistently down-regulated with increasing AD severity and is significantly associated with CDR, Braak score, and AD case status across multiple cortical region meta-analyses. No specific mechanism was experimentally validated in this study."	0.4773
31591557	Nature neuroscience	2019	An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations.		circMAN2A1	hsa_circ_MAN2A1	MAN2A1	Alzheimer disease 	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR; RNA-seq	"circMAN2A1 is up-regulated with increasing AD severity and is significantly associated with CDR, Braak score, and AD case status across multiple cortical region meta-analyses. The study did not provide functional experimental validation for its mechanism."	0.4773
31591557	Nature neuroscience	2019	An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations.		circICA1	hsa_circ_ICA1	ICA1	Alzheimer disease 	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR; RNA-seq	circICA1 shows decreased expression with increasing AD dementia severity and is statistically associated with AD traits in RNA-seq analyses. It was included among five circRNAs whose RNA-seq direction of effect was validated by qPCR in a subset of discovery samples.	0.4773
31591557	Nature neuroscience	2019	An atlas of cortical circular RNA expression in Alzheimer disease brains demonstrates clinical and pathological associations.		circFMN1	hsa_circ_FMN1	FMN1	Alzheimer disease 	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR; RNA-seq	circFMN1 is down-regulated with increasing AD severity and is consistently associated with quantitative AD traits (CDR and Braak score) across meta-analyses. It was included among the circRNAs validated for RNA-seq direction of effect using qPCR in a subset of discovery samples.	0.4773
31592229	International journal of biological sciences	2019	Circular RNA CircEZH2 Suppresses Transmissible Gastroenteritis Coronavirus-induced Opening of Mitochondrial Permeability Transition Pore via Targeting MiR-22 in IPEC-J2.		ssc_circ_009380	ssc_circ_EZH2	EZH2	transmissible gastroenteritis 	MONDO:0002269	gastroenteritis	down-regulated	RT-qPCR; ISH	"In porcine intestinal epithelial cells and infected piglet jejunum, circEZH2 is down-regulated upon TGEV infection. circEZH2 suppresses TGEV-induced mPTP opening by sponging miR-22 and regulating miR-22 targets (HK2 and IL-6) and NF-kappaB signaling."	0.7328
31593832	Molecular therapy. Nucleic acids	2019	Circular RNA hsa_circ_0016070 Is Associated with Pulmonary Arterial Hypertension by Promoting PASMC Proliferation.	hsa_circ_0016070				pulmonary arterial hypertension 	MONDO:0015924	pulmonary arterial hypertension	up-regulated	RT-qPCR; Microarray	"hsa_circ_0016070 is up-regulated in lung tissues from COPD patients with PAH and promotes PASMC proliferation and G1/S cell-cycle progression. Mechanistically, it suppresses miR-942 and elevates CCND1 expression, supporting a circRNA/miRNA/mRNA regulatory axis linked to vascular remodeling in PAH."	0.5804
31595711	Cancer medicine	2019	Hsa_circ_0028502 and hsa_circ_0076251 are potential novel biomarkers for hepatocellular carcinoma.	hsa_circ_0028502		hsa_circ_SLC24A6	SLC24A6	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	hsa_circ_0028502 is significantly down-regulated in HCC tissues and shows progressively decreased expression from CH to LC to HCC. It has diagnostic value for distinguishing HCC from LC/CH and LC from CH based on ROC analysis.	0.6813
31595711	Cancer medicine	2019	Hsa_circ_0028502 and hsa_circ_0076251 are potential novel biomarkers for hepatocellular carcinoma.	hsa_circ_0076251		hsa_circ_ZFAND3	ZFAND3	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0076251 is significantly down-regulated in HCC tissues and decreases from CH to LC to HCC. It shows diagnostic value by ROC analysis and serves as an independent prognostic indicator, where higher expression is associated with more favorable survival in HCC patients."	0.6813
31605010	Scientific reports	2019	Circular RNA differential expression in blood cell populations and exploration of circRNA deregulation in pediatric acute lymphoblastic leukemia.			hsa_circ_AFF3	AFF3	pediatric B-precursor acute lymphoblastic leukemia 	MONDO:0000872	B-cell childhood acute lymphoblastic leukemia	up-regulated	RT-qPCR	"circAFF3 is overexpressed in pediatric BCP-ALL compared with healthy B-cells. The study provides in-silico functional predictions suggesting potential miRNA interactions (e.g., miR-296_5p), putative RBP motifs, and an ORF spanning the backsplice, but no direct functional assays were performed."	0.4535
31605010	Scientific reports	2019	Circular RNA differential expression in blood cell populations and exploration of circRNA deregulation in pediatric acute lymphoblastic leukemia.			hsa_circ_BCL2	BCL2	B-cell precursor acute lymphoblastic leukemia 	MONDO:0020511	precursor B-cell acute lymphoblastic leukemia	up-regulated	RT-qPCR	circBCL2(intronic) shows increased expression in the ETV6-RUNX1 cytogenetic subtype of BCP-ALL. The paper does not provide a functional mechanism for this circRNA beyond expression differences.	0.6254
31605010	Scientific reports	2019	Circular RNA differential expression in blood cell populations and exploration of circRNA deregulation in pediatric acute lymphoblastic leukemia.			hsa_circ_HIPK3	HIPK3	pediatric B-precursor acute lymphoblastic leukemia 	MONDO:0000872	B-cell childhood acute lymphoblastic leukemia	up-regulated	RT-qPCR	"circHIPK3 is upregulated in pediatric BCP-ALL (qRT-PCR in PDX samples). Prior evidence cited by the authors indicates it localizes to the cytoplasm and can sponge miRNAs (e.g., miR-124), suggesting a potential role in supporting leukemic cell growth, though this mechanism is not directly tested here."	0.4128
31605010	Scientific reports	2019	Circular RNA differential expression in blood cell populations and exploration of circRNA deregulation in pediatric acute lymphoblastic leukemia.			hsa_circ_PAX5	PAX5	pediatric B-precursor acute lymphoblastic leukemia 	MONDO:0000872	B-cell childhood acute lymphoblastic leukemia	up-regulated	RT-qPCR	"circPAX5 is generally upregulated in pediatric BCP-ALL (qRT-PCR in PDX samples). The authors provide computational predictions of miRNA-binding sites (including miR-124) and possible coding potential (ORF spanning the backsplice), but no direct functional validation is presented."	0.4535
31605010	Scientific reports	2019	Circular RNA differential expression in blood cell populations and exploration of circRNA deregulation in pediatric acute lymphoblastic leukemia.			hsa_circ_PVT1	PVT1	pediatric B-precursor acute lymphoblastic leukemia 	MONDO:0000872	B-cell childhood acute lymphoblastic leukemia	up-regulated	RT-qPCR	"circPVT1 is generally upregulated in pediatric BCP-ALL (qRT-PCR in PDX samples). The paper mainly contextualizes this finding with prior literature describing oncogenic, miRNA-sponge-based mechanisms (e.g., miR-125/let-7 and Bcl-2/c-Myc regulation), but does not experimentally test these mechanisms in this cohort."	0.4128
31605569	FEBS open bio	2019	Circular RNA expression profiles in extracellular vesicles from the plasma of patients with pancreatic ductal adenocarcinoma.	hsa_circ_0002130		hsa_circ_C3	C3	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0002130 is up-regulated in plasma extracellular vesicles from PDAC patients versus healthy controls, identified by circRNA-seq and supported by RT-qPCR validation. Its downstream miRNA interactions are only computationally predicted via a circRNA_miRNA network."	0.5466
31605569	FEBS open bio	2019	Circular RNA expression profiles in extracellular vesicles from the plasma of patients with pancreatic ductal adenocarcinoma.	hsa_circ_0000896		hsa_circ_FARSA	FARSA	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0000896 is up-regulated in plasma EVs from PDAC patients and was among circRNAs validated by RT-qPCR. It is detectable in pancreatic cancer cell lines and shows particularly high expression in SW1990; miRNA targets are computationally predicted only.	0.62
31605569	FEBS open bio	2019	Circular RNA expression profiles in extracellular vesicles from the plasma of patients with pancreatic ductal adenocarcinoma.	hsa_circ_0101692		hsa_circ_EGLN3	EGLN3	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0101692 is up-regulated in plasma EVs from PDAC patients versus controls and is among the circRNAs experimentally validated by RT-qPCR. Its miRNA interactions are predicted bioinformatically without functional experiments.	0.5466
31605569	FEBS open bio	2019	Circular RNA expression profiles in extracellular vesicles from the plasma of patients with pancreatic ductal adenocarcinoma.	hsa_circ_0005882		hsa_circ_STK39	STK39	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005882 is up-regulated in plasma EVs from PDAC patients and is part of the set validated by RT-qPCR, supporting the sequencing trend. Its functional mechanism is not experimentally tested; only predicted miRNA binding is provided."	0.5466
31605569	FEBS open bio	2019	Circular RNA expression profiles in extracellular vesicles from the plasma of patients with pancreatic ductal adenocarcinoma.	hsa_circ_0001250		hsa_circ_GRAMD4	GRAMD4	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0001250 is up-regulated in plasma EVs of PDAC patients and is included in the RT-qPCR validation set supporting sequencing results. Mechanistic/functional roles remain untested beyond predicted miRNA binding.	0.5466
31605569	FEBS open bio	2019	Circular RNA expression profiles in extracellular vesicles from the plasma of patients with pancreatic ductal adenocarcinoma.	hsa_circ_0037096		hsa_circ_PCSK6	PCSK6	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0037096 is up-regulated in PDAC patient plasma EVs and is among the top circRNAs validated by RT-qPCR to match circRNA-seq. Functional mechanisms are limited to predicted circRNA_miRNA interactions.	0.5466
31605569	FEBS open bio	2019	Circular RNA expression profiles in extracellular vesicles from the plasma of patients with pancreatic ductal adenocarcinoma.	hsa_circ_0000128		hsa_circ_SCNM1	SCNM1	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0000128 is up-regulated in PDAC plasma EVs and is additionally detected in pancreatic cancer cell lines with relatively high expression in SW1990. The paper provides only computational prediction of miRNA binding without downstream functional validation.	0.62
31605569	FEBS open bio	2019	Circular RNA expression profiles in extracellular vesicles from the plasma of patients with pancreatic ductal adenocarcinoma.	hsa_circ_0000606		hsa_circ_ICE2	ICE2	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0000606 is up-regulated in PDAC plasma EVs and belongs to the circRNAs selected for RT-qPCR validation supporting the sequencing results. Mechanistic details are limited to predicted circRNA_miRNA interactions.	0.5466
31605569	FEBS open bio	2019	Circular RNA expression profiles in extracellular vesicles from the plasma of patients with pancreatic ductal adenocarcinoma.	hsa_circ_0103896		hsa_circ_G027572	G027572	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0103896 is down-regulated in PDAC plasma EVs and is part of the set used for RT-qPCR validation supporting the sequencing trend. No functional assays were performed; miRNA interactions are predicted computationally.	0.5466
31605569	FEBS open bio	2019	Circular RNA expression profiles in extracellular vesicles from the plasma of patients with pancreatic ductal adenocarcinoma.	hsa_circ_0006662		hsa_circ_GLS	GLS	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0006662 is down-regulated in plasma EVs from PDAC patients, supported by inclusion in the RT-qPCR validation set. Only bioinformatic miRNA-binding predictions are provided without functional validation."	0.5466
31605569	FEBS open bio	2019	Circular RNA expression profiles in extracellular vesicles from the plasma of patients with pancreatic ductal adenocarcinoma.	hsa_circ_0092763		hsa_circ_ATRNL1	ATRNL1	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0092763 is down-regulated in PDAC plasma EVs and is included in the RT-qPCR validation set. The study reports only predicted miRNA binding without functional experiments.	0.5466
31605569	FEBS open bio	2019	Circular RNA expression profiles in extracellular vesicles from the plasma of patients with pancreatic ductal adenocarcinoma.	hsa_circ_0035432		hsa_circ_CGNL1	CGNL1	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0035432 is down-regulated in PDAC plasma EVs and is included in the RT-qPCR validation panel supporting the sequencing trend. Only computational miRNA interaction predictions are provided.	0.5466
31605569	FEBS open bio	2019	Circular RNA expression profiles in extracellular vesicles from the plasma of patients with pancreatic ductal adenocarcinoma.	hsa_circ_0094190		hsa_circ_KAT6B	KAT6B	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0094190 is down-regulated in PDAC plasma EVs and is included among circRNAs used for RT-qPCR validation. Its mechanism is not experimentally determined beyond predicted circRNA_miRNA interactions.	0.5466
31608065	Frontiers in immunology	2019	Hsa_circ_0000479 as a Novel Diagnostic Biomarker of Systemic Lupus Erythematosus.	hsa_circ_0000479				systemic lupus erythematosus 	MONDO:0007915	systemic lupus erythematosus	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000479 is up-regulated in PBMCs from SLE patients and shows diagnostic value for distinguishing SLE from healthy controls and RA. Mechanistically, the study predicts a ceRNA network and implicates metabolic pathways and Wnt signaling; Wnt-16 is decreased in SLE PBMCs at mRNA and protein levels."	0.5849
31611906	Frontiers in genetics	2019	Exosomal Circular RNA as a Biomarker Platform for the Early Diagnosis of Immune-Mediated Demyelinating Disease.	hsa_circ_0087862		hsa_circ_RAD23B	RAD23B	immune-mediated demyelinating diseases 	MONDO:0002562	demyelinating disease	up-regulated	RT-qPCR; Microarray	Exosomal hsa_circ_0087862 is up-regulated in CSF from patients with immune-mediated demyelinating diseases and shows perfect diagnostic performance (AUC=1.00) in this cohort. The study also predicts that it may participate in a ceRNA network with miRNAs and downstream mRNAs such as GRIN2B.	0.5047
31611906	Frontiers in genetics	2019	Exosomal Circular RNA as a Biomarker Platform for the Early Diagnosis of Immune-Mediated Demyelinating Disease.	hsa_circ_0012077		hsa_circ_PTPRF	PTPRF	immune-mediated demyelinating diseases 	MONDO:0002562	demyelinating disease	up-regulated	RT-qPCR; Microarray	"Exosomal hsa_circ_0012077 is up-regulated in CSF from patients with immune-mediated demyelinating diseases and has perfect diagnostic performance (AUC=1.00) in this cohort. Its expression level is correlated with CSF IgG levels, and it is predicted to act in a ceRNA network involving miRNAs and target genes such as GRIN2B."	0.5534
31612035	Oncology letters	2019	Selective downregulation of distinct circRNAs in the tissues and plasma of patients with primary hepatic carcinoma.	hsa_circ_0003056	circPITPNB	hsa_circ_PITPNB	PITPNB	primary hepatic carcinoma 	MONDO:0002691	liver cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0003056 (circPITPNB; host gene PITPNB) is significantly down-regulated in PHC tumor tissues versus adjacent non-tumorous tissues. The study predicts it may act as a miRNA sponge within a circRNA_miRNA_mRNA ceRNA network linked to stem-cell pluripotency-related pathways, but functional validation is not provided."	0.4032
31612035	Oncology letters	2019	Selective downregulation of distinct circRNAs in the tissues and plasma of patients with primary hepatic carcinoma.	hsa_circ_0067127		hsa_circ_ALDH1L1	ALDH1L1	primary hepatic carcinoma 	MONDO:0002691	liver cancer	down-regulated	RT-qPCR	"hsa_circ_0067127 (host gene ALDH1L1) is significantly down-regulated in PHC patient plasma versus healthy donors. The study predicts it may function as a miRNA sponge in a ceRNA network with enrichment in ubiquitin-mediated proteolysis and prostate cancer pathways, and its plasma level is associated with AFP status."	0.348
31612046	Oncology letters	2019	"Changing expression profiles of lncRNAs, circRNAs and mRNAs in esophageal squamous carcinoma."	hsa_circ_0025580	Circ-0025580			esophageal squamous carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circ_0025580 is up-regulated in ESCC tumor tissues versus matched para-carcinoma tissues and was validated by RT-qPCR following microarray profiling. The study mainly used bioinformatics/ceRNA network construction to infer potential functions rather than experimentally defining a specific mechanism for this circRNA.	0.4032
31612046	Oncology letters	2019	"Changing expression profiles of lncRNAs, circRNAs and mRNAs in esophageal squamous carcinoma."	hsa_circ_0024108	Circ-0024108			esophageal squamous carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0024108 is up-regulated in ESCC tumor tissues versus matched para-carcinoma tissues, supported by microarray profiling and RT-qPCR validation. The paper does not report a specific downstream target or experimentally verified mechanism for this circRNA."	0.4032
31612046	Oncology letters	2019	"Changing expression profiles of lncRNAs, circRNAs and mRNAs in esophageal squamous carcinoma."	hsa_circ_0025933	Circ-0025933			esophageal squamous carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0025933 is up-regulated in ESCC tissues compared with matched para-carcinoma tissues, supported by microarray and RT-qPCR validation. No specific experimentally validated miRNA/mRNA axis for this circRNA is reported in the provided text."	0.4032
31616472	Frontiers in genetics	2019	Identification of hsa_circ_0001821 as a Novel Diagnostic Biomarker in Gastric Cancer via Comprehensive Circular RNA Profiling.	hsa_circ_0001821		hsa_circ_PVT1	PVT1	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001821 (host gene PVT1) is significantly down-regulated in gastric cancer tissues and in patients¡¯ whole blood, and shows cytoplasmic enrichment, suggesting a post-transcriptional regulatory role. It has diagnostic potential for GC (ROC AUC up to 0.872 in blood; improved to 0.933 when combined with CEA/CA199/CA125) and is associated with tumor depth and lymph node metastasis. A circRNA_miRNA_mRNA network involving seven predicted miRNAs was proposed but not experimentally validated."	0.6981
31619168	BMC cardiovascular disorders	2019	Association of circular RNAs and environmental risk factors with coronary heart disease.	hsa_circ_0008507				coronary heart disease 	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR; Microarray	"hsa_circ_0008507 is up-regulated in peripheral blood leukocytes of CHD patients and acts as an independent risk factor. High hsa_circ_0008507 combined with smoking shows a significant interaction that markedly increases CHD risk, and it has moderate diagnostic performance (AUC 0.75)."	0.5534
31619168	BMC cardiovascular disorders	2019	Association of circular RNAs and environmental risk factors with coronary heart disease.	hsa_circ_0001946	Cdr1as			coronary heart disease 	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001946 (Cdr1as) is up-regulated in CHD peripheral blood leukocytes and is an independent risk factor with diagnostic value (AUC 0.71). The study suggests a potential hsa_circ_0001946/miR-7-5p/EGFR mRNA-related axis influencing apoptosis and proliferation, based on bioinformatics rather than direct mechanistic experiments in CHD."	0.5534
31619168	BMC cardiovascular disorders	2019	Association of circular RNAs and environmental risk factors with coronary heart disease.	hsa_circ_0000284	circHIPK3	hsa_circ_HIPK3	HIPK3	coronary heart disease 	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000284 (circHIPK3) is up-regulated in CHD peripheral blood leukocytes and is an independent risk factor with diagnostic value (AUC 0.68). The study does not establish a CHD-specific molecular mechanism, but discusses circHIPK3 in relation to endothelial cell proliferation/migration and vascular dysfunction based on prior evidence."	0.5202
31619685	Nature communications	2019	N6-methyladenosine modification of circNSUN2 facilitates cytoplasmic export and stabilizes HMGA2 to promote colorectal liver metastasis.		circRNA_103783	hsa_circ_NSUN2	NSUN2	colorectal carcinoma 	MONDO:0024331	colorectal carcinoma	up-regulated	RT-qPCR; Northern Blot; Microarray	"circNSUN2 is up-regulated in CRC with liver metastasis (in tumor tissues and serum) and is associated with poor survival. Its m6A-dependent export (via YTHDC1) increases cytoplasmic circNSUN2, which forms a ternary complex with IGF2BP2 and HMGA2 to stabilize HMGA2 mRNA, promoting invasion/EMT and liver metastasis."	0.8798
31623606	Molecular cancer	2019	CircPLEKHM3 acts as a tumor suppressor through regulation of the miR-9/BRCA1/DNAJB6/KLF4/AKT1 axis in ovarian cancer.		CircPLEKHM3	hsa_circ_PLEKHM3	PLEKHM3	ovarian cancer 	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR; ISH; RNA-seq	"CircPLEKHM3 is significantly down-regulated in ovarian cancer and further reduced in peritoneal metastases; lower levels associate with worse survival. Functionally, it suppresses proliferation, migration, EMT, and tumor growth. Mechanistically, circPLEKHM3 acts as a miR-9 sponge to upregulate BRCA1/DNAJB6/KLF4, thereby inhibiting AKT1 and Wnt/beta-catenin signaling and influencing response to Taxol/MK-2206 combination therapy."	0.8793
31623628	Molecular cancer	2019	Circular RNA FOXP1 promotes tumor progression and Warburg effect in gallbladder cancer by regulating PKLR expression.	hsa_circ_0008234	circFOXP1	hsa_circ_FOXP1	FOXP1	gallbladder cancer 	MONDO:0005411	gallbladder cancer	up-regulated	RT-qPCR; Northern Blot; RNA-seq	"circFOXP1 (hsa_circ_0008234) is up-regulated in gallbladder cancer and promotes proliferation, migration/invasion, tumor growth, and aerobic glycolysis while inhibiting apoptosis. It increases PKLR expression by binding PTBP1 to stabilize PKLR mRNA and also functions as a miR-370 sponge to de-repress PKLR, thereby enhancing the Warburg effect and associating with poor overall survival."	0.8871
31623653	Journal of hematology & oncology	2019	circRNA circAF4 functions as an oncogene to regulate MLL-AF4 fusion protein expression and inhibit MLL leukemia progression.		circAF4(EX3-4)	hsa_circ_AF4	AF4	MLL-AF4 leukemia 	MONDO:0850450	mixed phenotype acute leukemia with MLL rearranged	up-regulated	RT-qPCR	"circAF4 is up-regulated in MLL-AF4 leukemia and functions as an oncogenic circRNA. It primarily localizes to the cytoplasm and sponges miR-128-3p, relieving repression of MLL-AF4 and promoting leukemic proliferation/leukemogenesis while inhibiting apoptosis; knockdown delays disease in a NOD-SCID xenograft model."	0.8587
31624242	Cell death & disease	2019	Circular RNA circ0005276 promotes the proliferation and migration of prostate cancer cells by interacting with FUS to transcriptionally activate XIAP.	hsa_circ_0005276		hsa_circ_XIAP	XIAP	Prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; RNA-seq	"circ0005276 is up-regulated in prostate cancer tissues and cell lines and promotes proliferation, migration/invasion, EMT, and in vivo tumor growth. Mechanistically, circ0005276 binds the RBP FUS and enhances FUS-dependent transcriptional activation of its host gene XIAP by promoting FUS binding to the XIAP promoter."	0.862
31626137	Medicine	2019	Circular RNA expression profile in peripheral whole blood of lung adenocarcinoma by high: Throughput sequencing.		circRNA5430			Lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circRNA5430 is up-regulated in peripheral whole blood of lung adenocarcinoma patients versus healthy controls, confirmed by RT-PCR/RT-qPCR in an independent validation cohort. The study suggests blood circRNAs may serve as noninvasive biomarkers, but no specific mechanism was experimentally validated for circRNA5430."	0.3588
31626137	Medicine	2019	Circular RNA expression profile in peripheral whole blood of lung adenocarcinoma by high: Throughput sequencing.		circRNA6783			Lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circRNA6783 is up-regulated in peripheral whole blood of lung adenocarcinoma patients versus healthy controls, confirmed by RT-PCR/RT-qPCR in an independent validation cohort. The study positions blood circRNAs as potential noninvasive biomarkers, but does not provide a specific validated mechanism for circRNA6783."	0.3588
31631067	Aging	2019	A circular RNA from APC inhibits the proliferation of diffuse large B-cell lymphoma by inactivating Wnt/beta-catenin signaling via interacting with TET1 and miR-888.	hsa_circ_0127621		hsa_circ_APC	APC	diffuse large B-cell lymphoma 	MONDO:0018905	diffuse large B-cell lymphoma	down-regulated	RT-qPCR; Microarray	"circ-APC is down-regulated in DLBCL tissues/cell lines/plasma and suppresses DLBCL proliferation and xenograft tumor growth. It upregulates APC via miR-888 sponging in the cytoplasm and via recruiting TET1 to the APC promoter in the nucleus, leading to inhibition of canonical Wnt/beta-catenin signaling and better patient survival when highly expressed."	0.8859
31636010	EBioMedicine	2019	Downregulation of circRNA DMNT3B contributes to diabetic retinal vascular dysfunction through targeting miR-20b-5p and BAMBI.	hsa_circ_0059802		hsa_circ_DNMT3B	DNMT3B	diabetic retinopathy 	MONDO:0005266	diabetic retinopathy	down-regulated	RT-qPCR; Microarray	"circDNMT3B is down-regulated in diabetic retinopathy and high-glucose_treated HRMECs. It mainly localizes in the cytoplasm and acts as a ceRNA sponge for miR-20b-5p, thereby restoring BAMBI levels and suppressing endothelial proliferation/migration/tube formation, improving retinal vascular dysfunction and visual impairment in diabetic rats."	0.7548
31636510	Cancer cell international	2019	Potential Role of circPVT1 as a proliferative factor and treatment target in esophageal carcinoma.	hsa_circ_0001821		hsa_circ_PVT1	PVT1	esophageal carcinoma 	MONDO:0019086	carcinoma of esophagus	up-regulated	RT-qPCR	"circPVT1 is up-regulated in esophageal carcinoma tissues and EC cell lines. Functionally, circPVT1 promotes EC cell proliferation/survival and enhances invasion, while its knockdown increases apoptosis. Mechanistically, it is suggested to counteract miR-4663 effects and modulate Pax-4/Pax-6 and PPARalpha/PPAR-gamma protein levels, implying a circRNA_miRNA_protein regulatory axis."	0.6369
31636511	Cancer cell international	2019	Identification of differentially expressed circRNAs and a novel hsa_circ_0000144 that promote tumor growth in gastric cancer.	hsa_circ_0000144	circSLAMF6	hsa_circ_SLAMF6	SLAMF6	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000144 (circSLAMF6, from SLAMF6) is up-regulated in gastric cancer and promotes GC cell proliferation, migration, and invasion. The study constructed a predicted circRNA_miRNA_mRNA ceRNA network for hsa_circ_0000144 and validated functional effects via siRNA knockdown in GC cell lines."	0.4852
31639291	Journal of cellular and molecular medicine	2019	CircRhoC promotes tumorigenicity and progression in ovarian cancer by functioning as a miR-302e sponge to positively regulate VEGFA.	hsa_circ_0013549		hsa_circ_RhoC	RhoC	ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circRhoC (circ_0013549) is overexpressed in ovarian cancer and promotes malignant phenotypes (viability, migration, invasion) and intraperitoneal dissemination in vivo. Mechanistically, it sponges miR-302e to increase VEGFA expression and may also directly bind VEGFA protein, forming a circRhoC/miR-302e/VEGFA regulatory axis."	0.7094
31642110	Journal of clinical laboratory analysis	2020	"Circular RNA LARP4 correlates with decreased Enneking stage, better histological response, and prolonged survival profiles, and it elevates chemosensitivity to cisplatin and doxorubicin via sponging microRNA-424 in osteosarcoma."			hsa_circ_LARP4	LARP4	osteosarcoma	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR	"circ-LARP4 is down-regulated in osteosarcoma tumor tissue and serves as a favorable biomarker: higher tumor expression associates with lower Enneking stage, better histological response, and longer DFS/OS. Functionally, circ-LARP4 overexpression increases chemosensitivity (notably to cisplatin and doxorubicin) by sponging miR-424, supported by rescue and luciferase assays."	0.7445
31648103	Molecular therapy. Nucleic acids	2019	circIFT80 Functions as a ceRNA of miR-1236-3p to Promote Colorectal Cancer Progression.	hsa_circ_0067835		hsa_circ_IFT80	IFT80	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circIFT80 (hsa_circ_0067835), derived from IFT80, is up-regulated in CRC plasma exosomes, tumor tissues, and CRC cell lines. It mainly localizes to the cytoplasm and promotes CRC proliferation, migration, invasion and EMT while inhibiting apoptosis, by acting as a ceRNA that sponges miR-1236-3p to increase HOXB7 expression."	0.8512
31648990	EBioMedicine	2019	Circular RNA circPICALM sponges miR-1265 to inhibit bladder cancer metastasis and influence FAK phosphorylation.	hsa_circ_0023919		hsa_circ_PICALM	PICALM	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR	"circPICALM is downregulated in bladder cancer and functions as a metastasis suppressor. It mainly localizes in the cytoplasm and sponges miR-1265 to de-repress STEAP4, thereby reducing FAK Y397 phosphorylation and inhibiting EMT and metastatic behaviors. Low circPICALM is associated with advanced clinicopathologic features and worse overall survival."	0.895
31654502	Journal of cellular and molecular medicine	2020	Circular RNA USP1 regulates the permeability of blood-tumour barrier via miR-194-5p/FLI1 axis.	hsa_circ_0000080		hsa_circ_USP1	USP1	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR; Microarray	"circ-USP1 is up-regulated in glioma-associated cerebral microvascular endothelial cells in an in vitro BTB model. It binds and suppresses miR-194-5p, thereby maintaining FLI1 expression and tight junction proteins (claudin-5, occludin, ZO-1) to reduce BTB permeability; circ-USP1 knockdown increases permeability and can enhance doxorubicin-induced glioma cell apoptosis across the BTB."	0.6959
31665067	Molecular cancer	2019	CircMYO10 promotes osteosarcoma progression by regulating miR-370-3p/RUVBL1 axis to enhance the transcriptional activity of beta-catenin/LEF1 complex via effects on chromatin remodeling.		hsa_cirRNA_103801	hsa_circ_MYO10	MYO10	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Northern Blot; ISH; Microarray	"circMYO10 is upregulated in osteosarcoma and promotes proliferation, EMT, and metastasis. Mechanistically, it sponges miR-370-3p (and also binds miR-877-3p), relieving repression of RUVBL1 and enhancing beta-catenin/LEF1-driven Wnt signaling and MYC transcription via TIP60-associated chromatin remodeling and H4K16 acetylation."	0.8834
31666098	Journal of experimental & clinical cancer research : CR	2019	CircWHSC1 promotes ovarian cancer progression by regulating MUC1 and hTERT through sponging miR-145 and miR-1182.	hsa_circ_0001387	Circ_0001387 / circWHSC1	hsa_circ_WHSC1	WHSC1	ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; Microarray	"circWHSC1 (hsa_circ_0001387), derived from WHSC1, is up-regulated in epithelial ovarian carcinoma and promotes proliferation, migration/invasion while inhibiting apoptosis. It functions as a ceRNA by sponging miR-145 and miR-1182 to increase MUC1 and hTERT expression, and can be secreted in exosomes to enhance peritoneal dissemination via effects on peritoneal mesothelial cells."	0.7302
31666927	Oncotarget	2019	"Assessment of circularized E7 RNA, GLUT1, and PD-L1 in anal squamous cell carcinoma."		circE7		E7	Anal squamous cell carcinoma 	MONDO:0006082	anal squamous cell carcinoma	unknown	RT-qPCR; RNA-seq	"In ASCC FFPE tumor samples, circE7 was detectable using divergent primer endpoint RT-PCR and RT-qPCR. Higher circE7 levels were associated with improved overall survival, supporting circE7 as a positive prognostic biomarker in HPV-driven ASCC."	0.5963
31672157	Molecular cancer	2019	Circ-AKT3 inhibits clear cell renal cell carcinoma metastasis via altering miR-296-3p/E-cadherin signals.	hsa_circ_0017252		hsa_circ_AKT3	AKT3	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	down-regulated	RT-qPCR; Microarray	"circ-AKT3 (hsa_circ_0017252), derived from AKT3, is down-regulated in ccRCC tissues and cell lines. It inhibits ccRCC migration/invasion and in vivo metastasis mainly by sponging miR-296-3p to restore E-cadherin (CDH1) expression, forming a circ-AKT3/miR-296-3p/E-cadherin ceRNA axis."	0.8314
31680981	Frontiers in pharmacology	2019	Construction and Analysis of circRNA-miRNA-mRNA Molecular Regulatory Networks During Herba Gelsemium elegans Intoxication.		mmu-circRNA-013703			acute GE poisoning 	MONDO:0029000	poisoning	dysregulated	RT-qPCR; Microarray	"In mouse acute GE intoxication, mmu-circRNA-013703 is dysregulated and was validated by RT-qPCR. The study proposes it functions as a miRNA sponge (notably involving mmu-miR-361-3p) within a circRNA_miRNA_mRNA co-expression network, potentially impacting survival/demise- and neuron/synapse-related pathways and serving as a biomarker candidate."	0.5922
31680981	Frontiers in pharmacology	2019	Construction and Analysis of circRNA-miRNA-mRNA Molecular Regulatory Networks During Herba Gelsemium elegans Intoxication.		mmu-circRNA-010022	mmu_circ_Gstp1	Gstp1	acute GE poisoning 	MONDO:0029000	poisoning	dysregulated	RT-qPCR; Microarray	"In mouse acute GE intoxication, mmu-circRNA-010022 (host gene Gstp1) is dysregulated and validated by RT-qPCR. It is one of two core circRNAs used to build a predicted circRNA_miRNA_mRNA network and is proposed as a potential biomarker candidate, with inferred involvement in survival/demise- and neuron/synapse-related pathways from GO/KEGG analyses."	0.5922
31686850	OncoTargets and therapy	2019	Serum circSETDB1 is a promising biomarker for predicting response to platinum-taxane-combined chemotherapy and relapse in high-grade serous ovarian cancer.		hsa_circ_006352	hsa_circ_SETDB1	SETDB1	high-grade serous ovarian cancer 	MONDO:0005211	ovarian serous adenocarcinoma	up-regulated	RT-qPCR	"Serum circSETDB1 (hsa_circ_006352, host gene SETDB1) is up-regulated in high-grade serous ovarian cancer and is higher in primary chemoresistant than chemosensitive patients. High serum circSETDB1 is associated with advanced FIGO stage, lymph node metastasis, and shorter progression-free survival, supporting its value as a non-invasive biomarker for diagnosis and treatment-response/relapse prediction."	0.4758
31689616	Molecular therapy. Nucleic acids	2019	hsa_circ_0092306 Targeting miR-197-3p Promotes Gastric Cancer Development by Regulating PRKCB in MKN-45 Cells.	hsa_circ_0092306				Gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0092306 is up-regulated in gastric cancer tissues and cell lines and promotes GC cell viability, migration/invasion while inhibiting apoptosis. Mechanistically, it binds miR-197-3p and upregulates PRKCB/PKCbeta1, forming a hsa_circ_0092306_miR-197-3p_PRKCB regulatory axis that drives tumor growth in vitro and in xenograft models."	0.8442
31692917	International journal of medical sciences	2019	Identifying circRNA-associated-ceRNA networks in retinal neovascularization in mice.		mmu_circRNA_002573			retinal neovascularization 	MONDO:0005283	retinal disorder	down-regulated	RT-qPCR; Microarray	mmu_circRNA_002573 is significantly down-regulated in OIR mouse retinas. It was included in a predicted ceRNA (circRNA_miRNA_mRNA) network and implicated by GO/KEGG analyses as potentially participating in neovascularization-related pathways such as MAPK signaling.	0.3684
31692917	International journal of medical sciences	2019	Identifying circRNA-associated-ceRNA networks in retinal neovascularization in mice.		mmu_circRNA_011180	mmu_circ_Dlc1	Dlc1	retinal neovascularization 	MONDO:0005283	retinal disorder	up-regulated	RT-qPCR; Microarray	mmu_circRNA_011180 (host gene Dlc1) is significantly up-regulated in OIR mouse retinas. It was used to build a predicted ceRNA network and implicated by GO/KEGG analyses as potentially involved in neovascularization-related pathways such as MAPK signaling.	0.3684
31692917	International journal of medical sciences	2019	Identifying circRNA-associated-ceRNA networks in retinal neovascularization in mice.		mmu_circRNA_016108	mmu_circ_Klhl2	Klhl2	retinal neovascularization 	MONDO:0005283	retinal disorder	up-regulated	RT-qPCR; Microarray	mmu_circRNA_016108 (host gene Klhl2) is significantly up-regulated in OIR mouse retinas. It was used for predicted circRNA_miRNA interaction/ceRNA network construction and implicated by KEGG analysis in angiogenesis-related pathways including MAPK signaling and the renin-angiotensin system.	0.3684
31692917	International journal of medical sciences	2019	Identifying circRNA-associated-ceRNA networks in retinal neovascularization in mice.		mmu_circRNA_22546			retinal neovascularization 	MONDO:0005283	retinal disorder	down-regulated	RT-qPCR; Microarray	mmu_circRNA_22546 is significantly down-regulated in OIR mouse retinas. It was included in predicted circRNA_miRNA_mRNA (ceRNA) networks and implicated by GO/KEGG analyses as potentially involved in neovascularization-related pathways such as MAPK signaling and the renin-angiotensin system.	0.3684
31694481	Technology in cancer research & treatment	2019	Upregulation of Circular RNA Itchy E3 Ubiquitin Protein Ligase Inhibits Cell Proliferation and Promotes Cell Apoptosis Through Targeting MiR-197 in Prostate Cancer.			hsa_circ_ITCH	ITCH	prostate cancer	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR	"In prostate cancer cell lines, circ-ITCH is down-regulated versus normal prostate epithelial cells. Forced circ-ITCH expression suppresses proliferation and increases apoptosis in PC-3 cells, mainly by targeting and downregulating miR-197, as supported by rescue experiments."	0.5554
31695488	Cancer management and research	2019	Knockdown of EBV-encoded circRNA circRPMS1 suppresses nasopharyngeal carcinoma cell proliferation and metastasis through sponging multiple miRNAs.		circRPMS1	ebv_circ_RPMS1	RPMS1	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"EBV-encoded circRPMS1 is up-regulated in EBV-positive and metastatic NPC and correlates with shorter OS/DFS. Functionally, circRPMS1 promotes NPC cell proliferation, invasion, tumor growth and EMT while suppressing apoptosis, mainly by sponging miR-203/miR-31/miR-451 (and reported binding to additional miRNAs in screening)."	0.7365
31695501	Cancer management and research	2019	Silencing Of hsa_circ_0008450 Represses Hepatocellular Carcinoma Progression Through Regulation Of microRNA-214-3p/EZH2 Axis.	hsa_circ_0008450	circ_0008450			hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"hsa_circ_0008450 is up-regulated in HCC tissues and cell lines and functions as an oncogenic circRNA. It sponges miR-214-3p to increase EZH2 expression, thereby promoting proliferation/migration/invasion and inhibiting apoptosis; its knockdown suppresses tumor growth in a Huh-7 xenograft model."	0.6536
31700498	Cancer cell international	2019	A 3-circular RNA signature as a noninvasive biomarker for diagnosis of colorectal cancer.	hsa_circ_0082182		hsa_circ_FAM71F2	FAM71F2	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	hsa_circ_0082182 is up-regulated in CRC patient plasma (and shows the same trend in CRC cell lines) and has potential noninvasive diagnostic value (ROC). Its downstream mechanism was explored by predicted circRNA_miRNA_mRNA (ceRNA) network and functional enrichment.	0.5047
31700498	Cancer cell international	2019	A 3-circular RNA signature as a noninvasive biomarker for diagnosis of colorectal cancer.	hsa_circ_0000370		hsa_circ_FLI1	FLI1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	hsa_circ_0000370 is up-regulated in CRC patient plasma (and shows the same trend in CRC cell lines). It demonstrates diagnostic potential by ROC analysis and is included in a combined 3-circRNA diagnostic panel; its mechanism was explored via predicted ceRNA network and enrichment analysis.	0.5047
31700498	Cancer cell international	2019	A 3-circular RNA signature as a noninvasive biomarker for diagnosis of colorectal cancer.	hsa_circ_0035445		hsa_circ_ALDH1A2	ALDH1A2	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0035445 is down-regulated in CRC patient plasma (and shows the same trend in CRC cell lines) and has potential diagnostic value by ROC analysis, including as part of a 3-circRNA diagnostic panel. Its downstream mechanism was explored via predicted circRNA_miRNA_mRNA (ceRNA) network and enrichment analysis (including MAPK signaling pathway in predictions)."	0.5047
31703640	BMC cancer	2019	CircAGFG1 promotes cervical cancer progression via miR-370-3p/RAF1 signaling.	hsa_circ_0058514		hsa_circ_AGFG1	AGFG1	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"CircAGFG1 is up-regulated in cervical cancer cell lines and promotes proliferation and migration while suppressing apoptosis. Mechanistically, it functions as a ceRNA by sponging miR-370-3p to relieve repression of RAF1 and activate RAF/MEK/ERK signaling."	0.6867
31709724	EMBO molecular medicine	2019	Therapeutic targeting of circ-CUX1/EWSR1/MAZ axis inhibits glycolysis and neuroblastoma progression.	hsa_circ_0132813		hsa_circ_CUX1	CUX1	neuroblastoma 	MONDO:0005072	neuroblastoma	up-regulated	RT-qPCR; Northern Blot; RNA-seq	"circ-CUX1 (hsa_circ_0132813), derived from CUX1, is up-regulated in neuroblastoma tissues and cell lines and mainly localizes in the nucleus. It promotes aerobic glycolysis and malignant phenotypes by binding the RBP EWSR1 and enhancing EWSR1-mediated MAZ transactivation, thereby altering transcription of CUX1 and other tumor-progression genes; high circ-CUX1 expression is associated with worse survival."	0.8956
31712601	Scientific reports	2019	Extracellular Vesicle-derived circular RNAs confers chemoresistance in Colorectal cancer.	hsa_circ_0032883		hsa_circ_EML5	EML5	colorectal cancer 	MONDO:0005575	colorectal cancer	dysregulated	RT-qPCR; Microarray	"hsa_circ_0032883 is an exosomal circRNA associated with FOLFOX response in CRC. It was upregulated in exosomes from FOLFOX-resistant HCT116-R cells versus parental cells, but downregulated in serum exosomes of non-responder patients versus responders, suggesting context-dependent dysregulation."	0.6809
31712601	Scientific reports	2019	Extracellular Vesicle-derived circular RNAs confers chemoresistance in Colorectal cancer.	hsa_circ_0066629		hsa_circ_DCBLD2	DCBLD2	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	hsa_circ_0066629 is upregulated in exosomes from FOLFOX-resistant HCT116-R CRC cells compared with parental cells and was selected as a validated candidate circRNA from the microarray screen. Its downstream mechanism was only explored via in-silico circRNA_miRNA_mRNA prediction without specific validated targets reported.	0.4761
31712601	Scientific reports	2019	Extracellular Vesicle-derived circular RNAs confers chemoresistance in Colorectal cancer.	hsa_circ_0002039		hsa_circ_OSBPL9	OSBPL9	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0002039 is an exosomal circRNA whose level increases in recipient HCT116-P cells after co-culture with FOLFOX-resistant HCT116-R cells, consistent with selective exosomal transfer. It is implicated in exosome-mediated chemoresistance transfer, but no specific downstream targets were experimentally validated."	0.6521
31712601	Scientific reports	2019	Extracellular Vesicle-derived circular RNAs confers chemoresistance in Colorectal cancer.	hsa_circ_0000338		hsa_circ_FCHSD2	FCHSD2	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000338 (circ_0000338), derived from FCHSD2, is upregulated in exosomes from FOLFOX-resistant HCT116-R CRC cells. siRNA knockdown in resistant cells increased drug-treated viability, and the authors propose a dual role with tumor-suppressive properties in cells but oncogenic effects when transferred via exosomes; it is suggested as a potential biomarker of chemoresistance."	0.7399
31713278	Journal of clinical laboratory analysis	2020	"Circ-MTO1 correlates with favorable prognosis and inhibits cell proliferation, invasion as well as miR-17-5p expression in prostate cancer."	hsa_circ_0076979		hsa_circ_MTO1	MTO1	prostate cancer	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR	"circ-MTO1 is down-regulated in prostate cancer tumor tissue and acts as a tumor suppressor by inhibiting proliferation and invasion in PC-3 cells. Clinically, higher tumor circ-MTO1 is associated with lower pathological T/N stage and independently predicts longer DFS and OS, and its overexpression reduces miR-17-5p levels."	0.7081
31718694	Journal of experimental & clinical cancer research : CR	2019	Circ-ASH2L promotes tumor progression by sponging miR-34a to regulate Notch1 in pancreatic ductal adenocarcinoma.			hsa_circ_ASH2L	ASH2L	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circ-ASH2L is up-regulated in PDAC tissues/cell lines and mainly localizes to the cytoplasm. It promotes invasion, proliferation, cell-cycle progression and angiogenesis by sponging miR-34a to relieve repression of Notch1 (Notch signaling activation), and high expression predicts worse overall survival."	0.8871
31718709	Molecular cancer	2019	Circ-HuR suppresses HuR expression and gastric cancer progression by inhibiting CNBP transactivation.	hsa_circ_0049027	Circ-HuR	hsa_circ_HuR	HuR	gastric cancer	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"circ-HuR (hsa_circ_0049027), a HuR-derived nuclear circRNA, is down-regulated in gastric cancer and suppresses malignant phenotypes (growth, invasion, metastasis) in vitro and in vivo. It directly binds CNBP and inhibits CNBP transactivation on the HuR promoter, thereby reducing HuR expression and downstream oncogenic effects; low circ-HuR is associated with worse patient survival."	0.8791
31719209	Aging	2019	TGF-beta- and lipopolysaccharide-induced upregulation of circular RNA PWWP2A promotes hepatic fibrosis via sponging miR-203 and miR-223.	hsa_circ_0074837	circ-PWWP2A	hsa_circ_PWWP2A	PWWP2A	hepatic fibrosis 	MONDO:0100430	fibrotic liver disease	up-regulated	RT-qPCR	"circ-PWWP2A (hsa_circ_0074837; mmu_circ_0000254) is upregulated in TGF-beta- or LPS-activated hepatic stellate cells and in CCl4-induced fibrotic mouse liver. It promotes HSC activation and proliferation by sponging miR-203 and miR-223, thereby increasing Fstl1 and TLR4, and its knockdown alleviates hepatic fibrosis in vivo."	0.6253
31719209	Aging	2019	TGF-beta- and lipopolysaccharide-induced upregulation of circular RNA PWWP2A promotes hepatic fibrosis via sponging miR-203 and miR-223.	mmu_circ_0000254	circ-PWWP2A	mmu_circ_PWWP2A	PWWP2A	hepatic fibrosis 	MONDO:0100430	fibrotic liver disease	up-regulated	RT-qPCR	"circ-PWWP2A (hsa_circ_0074837; mmu_circ_0000254) is upregulated in TGF-beta- or LPS-activated hepatic stellate cells and in CCl4-induced fibrotic mouse liver. It promotes HSC activation and proliferation by sponging miR-203 and miR-223, thereby increasing Fstl1 and TLR4, and its knockdown alleviates hepatic fibrosis in vivo."	0.6253
31719211	Aging	2019	Circular RNA circGRAMD1B inhibits gastric cancer progression by sponging miR-130a-3p and regulating PTEN and p21 expression.	hsa_circ_0004798	circGRAMD1B	hsa_circ_GRAMD1B	GRAMD1B	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"circGRAMD1B (hsa_circ_0004798), derived from GRAMD1B, is down-regulated in gastric cancer and mainly localized in the cytoplasm. It suppresses GC cell proliferation, migration, invasion and in vivo tumor growth/metastasis by acting as a ceRNA that sponges miR-130a-3p, thereby restoring PTEN and p21 expression."	0.8635
31721300	Journal of clinical laboratory analysis	2020	Reduced expression of circRNA hsa_circ_0067582 in human gastric cancer and its potential diagnostic values.	hsa_circ_0067582		hsa_circ_RASA2	RASA2	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"hsa_circ_0067582 is significantly down-regulated in gastric cancer tissues versus adjacent normal tissues and shows moderate diagnostic performance by ROC analysis. Lower expression is associated with longer overall survival, suggesting potential prognostic value. Mechanistically, the study only provides bioinformatic prediction that it may function as a miRNA sponge (ceRNA), without experimental validation of specific miRNAs or downstream targets."	0.6355
31722712	Molecular cancer	2019	circLMTK2 acts as a sponge of miR-150-5p and promotes proliferation and metastasis in gastric cancer.	hsa_circ_0001725	circLMTK2	hsa_circ_LMTK2	LMTK2	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"circLMTK2 (hsa_circ_0001725), derived from LMTK2, is up-regulated in gastric cancer and mainly localizes to the cytoplasm. It promotes proliferation, tumourigenicity, migration/invasion and metastasis by sponging miR-150-5p to increase c-Myc expression, and high circLMTK2 predicts poor overall survival."	0.8837
31722716	Molecular cancer	2019	circGSK3beta promotes metastasis in esophageal squamous cell carcinoma by augmenting beta-catenin signaling.		circRNA_103443	hsa_circ_GSK3beta	GSK3beta	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circGSK3beta is upregulated in ESCC and promotes migration, invasion, EMT, and tumor growth/metastasis. Mechanistically, it binds and inhibits GSK3beta, thereby enhancing beta-catenin signaling. Clinically, high circGSK3beta indicates poor survival, and plasma circGSK3beta shows diagnostic and recurrence/metastasis-predictive potential."	0.8941
31725681	Medicine	2019	Identification of breast cancer-related circRNAs by analysis of microarray and RNA-sequencing data: An observational study.	hsa_circ_0000519				breast cancer 	MONDO:0007254	breast cancer	unknown	Microarray	This study identified hsa_circ_0000519 as a key differentially expressed circRNA in breast cancer and placed it in a ceRNA module with hsa-mir-204 and the hub gene CDH2. The authors suggest it may be important in breast cancer pathogenesis and a potential therapeutic biomarker.	0.1768
31725681	Medicine	2019	Identification of breast cancer-related circRNAs by analysis of microarray and RNA-sequencing data: An observational study.	hsa_circ_0000375				breast cancer 	MONDO:0007254	breast cancer	unknown	Microarray	This study identified hsa_circ_0000375 as a key differentially expressed circRNA in breast cancer and included it in a ceRNA module with hsa-mir-3678 and the hub gene TWIST1.	0.1768
31728016	Cell death and differentiation	2020	Circular RNA cESRP1 sensitises small cell lung cancer cells to chemotherapy by sponging miR-93-5p to inhibit TGF-beta signalling.	hsa_circ_0084927	cESRP1	hsa_circ_ESRP1	ESRP1	small cell lung cancer 	MONDO:0008433	small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"In SCLC, cESRP1 is down-regulated in chemoresistant cells and patient tumors. It localizes mainly to the cytoplasm and acts as a ceRNA by sponging miR-93-5p to upregulate Smad7 and p21(CDKN1A), thereby inhibiting TGF-beta/Smad-driven EMT and enhancing chemotherapy sensitivity. Low cESRP1 expression is associated with poorer overall survival and serves as an independent prognostic marker."	0.8933
31729134	Journal of cellular and molecular medicine	2020	circFBXL5 promotes breast cancer progression by sponging miR-660.	hsa_circ_0125597	circFBXL5	hsa_circ_FBXL5	FBXL5	breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circFBXL5 is up-regulated in breast cancer (notably in lung metastatic tissues) and its high expression is associated with worse patient outcome. Functionally, circFBXL5 promotes proliferation and lung metastasis/migration, and mechanistically acts as a ceRNA sponge for miR-660 to increase SRSF6 expression via the circFBXL5/miR-660/SRSF6 axis."	0.7404
31733095	Journal of cellular and molecular medicine	2020	Circular RNA circFOXO3 promotes prostate cancer progression through sponging miR-29a-3p.	hsa_circ_0006404		hsa_circ_FOXO3	FOXO3	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circFOXO3 is up-regulated in prostate cancer tissues and serum and promotes PCa cell proliferation and cell-cycle progression while inhibiting apoptosis. Mechanistically, it acts as a ceRNA sponge for miR-29a-3p, thereby relieving repression of SLC25A15 and contributing to PCa progression; it may also have diagnostic biomarker potential in serum."	0.8246
31737058	Frontiers in genetics	2019	Identification of Serum Exosomal hsa-circ-0004771 as a Novel Diagnostic Biomarker of Colorectal Cancer.	hsa_circ_0004771		hsa_circ_NRIP1	NRIP1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"This study identifies circulating serum exosomal hsa-circ-0004771 (circNRIP1) as up-regulated in colorectal cancer and evaluates it as a diagnostic biomarker using qRT-PCR and ROC analysis. Postoperative decrease and exosome-inhibition experiments support that its elevated serum exosomal level is tumor-derived, while its biological mechanism in CRC was not resolved."	0.5047
31746073	Journal of clinical laboratory analysis	2020	Ectopic expression of CYP24A1 circular RNA hsa_circ_0060927 in uterine leiomyomas.	hsa_circ_0060927		hsa_circ_CYP24A1	CYP24A1	uterine leiomyomas 	MONDO:0007886	uterine corpus leiomyoma	up-regulated	RT-qPCR	"This study reports ectopic expression of hsa_circ_0060927 (from CYP24A1) in a subset of uterine leiomyoma tissues while absent in adjacent normal tissues, and finds no significant association with MED12 mutation status. A miRNA-sponging mechanism (e.g., via miR-1264 affecting DNMT1/SOCS3 methylation) is discussed as a hypothesis but not experimentally validated here."	0.429
31746333	Bioscience reports	2019	CircZFR serves as a prognostic marker to promote bladder cancer progression by regulating miR-377/ZEB2 signaling.	hsa_circ_0072088	hsa_circRNA_103809	hsa_circ_ZFR	ZFR	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"CircZFR is up-regulated in bladder cancer tissues and cell lines and is associated with worse PFS/OS. Functionally, circZFR promotes proliferation, migration and invasion and inhibits apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-377 to upregulate ZEB2, and ZEB2 restoration rescues the effects of circZFR knockdown."	0.7929
31746384	Molecular medicine reports	2020	Construction and analysis of circular RNA molecular regulatory networks in clear cell renal cell carcinoma.	hsa_circ_0031594		hsa_circ_EGLN3	EGLN3	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	Microarray	hsa_circ_0031594 was identified from a CCRCC circRNA microarray dataset as an upregulated differentially expressed circRNA and included among key circRNAs used to construct a circRNA_miRNA_mRNA regulatory network.	0.1768
31746384	Molecular medicine reports	2020	Construction and analysis of circular RNA molecular regulatory networks in clear cell renal cell carcinoma.	hsa_circ_0001968		hsa_circ_PPP6R3	PPP6R3	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	Microarray	hsa_circ_0001968 was identified as an upregulated differentially expressed circRNA in CCRCC microarray data and was included among the key circRNAs used for downstream network construction.	0.1768
31746384	Molecular medicine reports	2020	Construction and analysis of circular RNA molecular regulatory networks in clear cell renal cell carcinoma.	hsa_circ_0003596		hsa_circ_COL5A1	COL5A1	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	Microarray	hsa_circ_0003596 was found upregulated in CCRCC microarray analysis and was part of the circRNA set used to build the circRNA_miRNA_mRNA regulatory network.	0.1768
31746384	Molecular medicine reports	2020	Construction and analysis of circular RNA molecular regulatory networks in clear cell renal cell carcinoma.	hsa_circ_0058794		hsa_circ_AGAP1	AGAP1	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	Microarray	hsa_circ_0058794 was an upregulated circRNA identified from the CCRCC microarray dataset and included among the circRNAs used to construct circRNA_miRNA_mRNA regulatory networks.	0.1768
31746384	Molecular medicine reports	2020	Construction and analysis of circular RNA molecular regulatory networks in clear cell renal cell carcinoma.	hsa_circ_0001873		hsa_circ_SYK	SYK	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	Microarray	hsa_circ_0001873 was identified as an upregulated circRNA in CCRCC microarray analysis and was included among key circRNAs for circRNA_miRNA_mRNA network construction.	0.1768
31746384	Molecular medicine reports	2020	Construction and analysis of circular RNA molecular regulatory networks in clear cell renal cell carcinoma.	hsa_circ_0003748		hsa_circ_IP6K2	IP6K2	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	down-regulated	Microarray	hsa_circ_0003748 was identified as a downregulated circRNA in CCRCC microarray analysis and was included among the key differentially expressed circRNAs used for downstream network analyses.	0.1768
31746384	Molecular medicine reports	2020	Construction and analysis of circular RNA molecular regulatory networks in clear cell renal cell carcinoma.	hsa_circ_0003997		hsa_circ_CLMP	CLMP	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	down-regulated	Microarray	hsa_circ_0003997 was identified as a downregulated circRNA in CCRCC microarray data and was among the differentially expressed circRNAs used for subsequent regulatory-network analysis.	0.1768
31746384	Molecular medicine reports	2020	Construction and analysis of circular RNA molecular regulatory networks in clear cell renal cell carcinoma.	hsa_circ_0000223		hsa_circ_STAM	STAM	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	down-regulated	Microarray	hsa_circ_0000223 was identified as a downregulated circRNA in CCRCC using microarray data and was included among the most significant circRNAs reported by this analysis.	0.1768
31746384	Molecular medicine reports	2020	Construction and analysis of circular RNA molecular regulatory networks in clear cell renal cell carcinoma.	hsa_circ_0092367				clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	down-regulated	Microarray	hsa_circ_0092367 was identified as a downregulated circRNA in CCRCC microarray analysis and was included among the most significant circRNAs reported.	0.1768
31746384	Molecular medicine reports	2020	Construction and analysis of circular RNA molecular regulatory networks in clear cell renal cell carcinoma.	hsa_circ_0092360		hsa_circ_RPL23A	RPL23A	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	down-regulated	Microarray	hsa_circ_0092360 was identified as a downregulated circRNA in CCRCC microarray analysis and was included among the most significant circRNAs reported in this study.	0.1768
31747387	Medical science monitor : international medical journal of experimental and clinical research	2019	Identification of Potentially Functional CircRNA-miRNA-mRNA Regulatory Network in Gastric Carcinoma using Bioinformatics Analysis.	hsa_circ_0009076	circNRDC	hsa_circ_NRDC	NRDC	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	Microarray	"hsa_circ_0009076 (circNRDC) is identified as a down-regulated circRNA in gastric cancer tissues by GEO microarray integration. The study predicts a circRNA/miRNA/mRNA axis hsa_circ_0009076_hsa-mir-143-3p_SERPINE1 as part of a putative ceRNA regulatory network, without experimental wet-lab validation."	0.1768
31747387	Medical science monitor : international medical journal of experimental and clinical research	2019	Identification of Potentially Functional CircRNA-miRNA-mRNA Regulatory Network in Gastric Carcinoma using Bioinformatics Analysis.	hsa_circ_0028190	circANAPC7	hsa_circ_ANAPC7	ANAPC7	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	Microarray	"hsa_circ_0028190 (circANAPC7) is identified as a down-regulated circRNA in gastric cancer tissues by GEO microarray integration. The study predicts two ceRNA axes involving this circRNA: hsa_circ_0028190_hsa-mir-4291_CDK6 and hsa_circ_0028190_hsa-mir-140-5p_TGFBR1, without experimental validation."	0.1768
31747387	Medical science monitor : international medical journal of experimental and clinical research	2019	Identification of Potentially Functional CircRNA-miRNA-mRNA Regulatory Network in Gastric Carcinoma using Bioinformatics Analysis.	hsa_circ_0041732	circFAM64A	hsa_circ_FAM64A	FAM64A	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	Microarray	"hsa_circ_0041732 (circFAM64A) is identified as a down-regulated circRNA in gastric cancer tissues by GEO microarray integration. The study predicts it may sponge hsa-mir-182-5p and thereby relate to THBS1 regulation within a putative ceRNA network, but indicates further experiments are needed."	0.1768
31749597	World journal of gastroenterology	2019	Increased circulating circular RNA_103516 is a novel biomarker for inflammatory bowel disease in adult patients.		circRNA_103516	hsa_circ_FNDC3B	FNDC3B	inflammatory bowel disease 	MONDO:0005265	inflammatory bowel disease	up-regulated	RT-qPCR	"circRNA_103516 is up-regulated in PBMCs from adult IBD patients (CD and UC) and shows diagnostic value by ROC analysis. Higher circRNA_103516 levels are associated with active disease and correlate with inflammatory cytokines, suggesting a proinflammatory role. Mechanistically, it is proposed to function as a miRNA sponge (not experimentally validated), with a negative correlation observed with hsa-miR-19b-1-5p in CD."	0.5121
31750237	Frontiers in oncology	2019	Up-Regulation of hsa_circ_0000517 Predicts Adverse Prognosis of Hepatocellular Carcinoma.	hsa_circ_0000517		hsa_circ_RPPH1	RPPH1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000517 is up-regulated in HCC tumor tissues and its high expression is associated with worse OS/DFS and higher TNM stage. Bioinformatics analyses predict it acts as a miRNA sponge, influencing targets such as TP53, MYC and AKT1 and enriching MAPK/Ras-related pathways, supporting its potential as a prognostic biomarker."	0.7278
31751911	Molecular therapy. Nucleic acids	2019	circPUM1 Promotes Tumorigenesis and Progression of Ovarian Cancer by Sponging miR-615-5p and miR-6753-5p.	hsa_circ_0000043		hsa_circ_PUM1	PUM1	ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circPUM1 is upregulated in ovarian cancer tissues and promotes proliferation, migration, invasion and metastasis while inhibiting apoptosis. Mechanistically, it functions as a ceRNA sponging miR-615-5p and miR-6753-5p to increase NF-kappaB and MMP2 expression, and it is also secreted via exosomes to act on peritoneal mesothelial cells, inducing MMT and enhancing peritoneal dissemination."	0.6544
31752442	Genes	2019	Coding and Non-Coding RNA Abnormalities in Bipolar Disorder.		cNEBL	hsa_circ_NEBL	NEBL	bipolar disorder 	MONDO:0004985	bipolar disorder	up-regulated	RNA-seq	cNEBL is reported as up-regulated in postmortem medial frontal gyrus tissue from bipolar disorder patients versus controls based on circRNA detection and differential expression analysis from non-polyadenylated RNA-seq data.	0.1768
31752442	Genes	2019	Coding and Non-Coding RNA Abnormalities in Bipolar Disorder.		cEPHA3	hsa_circ_EPHA3	EPHA3	bipolar disorder 	MONDO:0004985	bipolar disorder	up-regulated	RNA-seq	cEPHA3 is reported as up-regulated in postmortem medial frontal gyrus tissue from bipolar disorder patients versus controls based on circRNA differential expression from non-polyadenylated RNA-seq. The authors note potential relevance of EPHA3-related developmental processes in the central nervous system.	0.1768
31752867	Molecular cancer	2019	Circular RNA circERBB2 promotes gallbladder cancer progression by regulating PA2G4-dependent rDNA transcription.		circERBB2	hsa_circ_ERBB2	ERBB2	gallbladder cancer 	MONDO:0005411	gallbladder cancer	up-regulated	RT-qPCR; RNA-seq	"circERBB2 is up-regulated in gallbladder cancer and promotes tumor cell proliferation and xenograft growth. Mechanistically, it accumulates in nucleoli, binds PA2G4 and enhances PA2G4 nucleolar localization, strengthening the PA2G4/TIFIA/Pol I machinery to increase rDNA transcription (45S pre-rRNA). High circERBB2 expression is associated with worse overall survival in GBC patients."	0.8897
31754311	Cancer management and research	2019	Upregulation Of circMMP9 Promotes Osteosarcoma Progression Via Targeting miR-1265/CHI3L1 Axis.		circMMP9	hsa_circ_MMP9	MMP9	Osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circMMP9 is up-regulated in osteosarcoma tissues/cell lines and its high level associates with advanced stage/metastasis and poorer survival. Functionally, circMMP9 promotes proliferation, migration and invasion and suppresses apoptosis by acting as a cytoplasmic sponge for miR-1265, thereby increasing CHI3L1 expression."	0.7617
31754397	Theranostics	2019	The novel GINS4 axis promotes gastric cancer growth and progression by activating Rac1 and CDC42.		circMLLT10	hsa_circ_MLLT10	MLLT10	gastric cancer	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"circMLLT10 is up-regulated in gastric cancer and mainly localizes in the cytoplasm. It functions as a ceRNA by sponging miR-509-3-5p, relieving repression of GINS4 and promoting Rac1/CDC42 activation, thereby enhancing proliferation and metastasis while inhibiting apoptosis."	0.6742
31756170	Aging	2019	Circ_0006332 promotes growth and progression of bladder cancer by modulating MYBL2 expression via miR-143.	hsa_circ_0006332		hsa_circ_MYBL2	MYBL2	bladder cancer	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ_0006332 is up-regulated in bladder cancer tissues and mainly localizes in the cytoplasm. It promotes bladder cancer proliferation, invasion, EMT, and in vivo xenograft growth by acting as a ceRNA sponge for miR-143, thereby increasing MYBL2 expression; it also shows diagnostic potential (ROC AUC reported)."	0.8279
31758655	Cancer medicine	2020	Silencing circular RNA VANGL1 inhibits progression of bladder cancer by regulating miR-1184/IGFBP2 axis.	hsa_circ_0002623		hsa_circ_VANGL1	VANGL1	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"circVANGL1 is up-regulated in bladder cancer tissues and cell lines and predominantly localized in the cytoplasm. It promotes bladder cancer cell proliferation, migration, invasion and xenograft tumor growth by sponging miR-1184 to increase IGFBP2 expression (circVANGL1/miR-1184/IGFBP2 ceRNA axis)."	0.697
31758671	Molecular oncology	2020	Circ-TCF4.85 silencing inhibits cancer progression through microRNA-486-5p-targeted inhibition of ABCF2 in hepatocellular carcinoma.			hsa_circ_TCF4		hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circ_TCF4.85 is up-regulated in hepatocellular carcinoma tissues and cell lines and promotes malignant phenotypes. It acts as a miR-486-5p sponge to relieve repression of ABCF2, thereby enhancing proliferation/migration/invasion and inhibiting apoptosis; circ_TCF4.85 knockdown suppresses xenograft growth."	0.8071
31760376	Molecular therapy. Nucleic acids	2019	Characterization of a Prostate- and Prostate Cancer-Specific Circular RNA Encoded by the Androgen Receptor Gene.		circAR3	hsa_circ_AR	AR	prostate cancer 	MONDO:0008315	prostate cancer	dysregulated	RT-qPCR; ISH	"This study characterizes circAR3 (from the AR gene) as a prostate/PCa-derived circRNA that is detectable in patient plasma and mouse xenograft serum. Tissue circAR3 decreases with progression to CRPC, while plasma circAR3 is higher in high-risk primary PCa (high Gleason score, lymph node metastasis) and disappears after prostatectomy. Functionally, circAR3 does not regulate AR signaling, proliferation, or invasion in tested PCa cell models."	0.8043
31767812	Aging	2019	Circular RNA CircCCNB1 sponges micro RNA-449a to inhibit cellular senescence by targeting CCNE2.	hsa_circ_0001495		hsa_circ_CCNB1	CCNB1	cellular senescence 			down-regulated	RT-qPCR; RNA-seq	"CircCCNB1 is down-regulated in senescent human diploid fibroblasts and suppresses cellular senescence. It functions mainly as a ceRNA sponge for miR-449a, thereby relieving repression of CCNE2 and supporting cell cycle/proliferation; it also binds multiple proteins that may influence circCCNB1 stability."	0.7655
31767835	Cell death & disease	2019	CircRNA-ENO1 promoted glycolysis and tumor progression in lung adenocarcinoma through upregulating its host gene ENO1.	hsa_circ_0000013		hsa_circ_ENO1	ENO1	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circ-ENO1 (circ-0000013) is up-regulated in LUAD tissues and cell lines and promotes glycolysis and malignant phenotypes (proliferation, migration, EMT, tumor growth/metastasis) while suppressing apoptosis. Mechanistically, it localizes mainly in the cytoplasm and functions as a ceRNA that sponges miR-22-3p to upregulate its host gene ENO1, enhancing glycolysis and LUAD progression."	0.8401
31772143	Aging	2019	Circular RNA hsa_circ_0000515 acts as a miR-326 sponge to promote cervical cancer progression through up-regulation of ELK1.	hsa_circ_0000515				cervical cancer	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000515 is up-regulated in cervical cancer tissues and cell lines and functions as an oncogenic circRNA. It sponges miR-326 to relieve repression of ELK1, thereby promoting proliferation and invasion while inhibiting apoptosis and autophagy, and its knockdown suppresses xenograft tumor growth. High hsa_circ_0000515 expression is associated with worse overall survival."	0.8229
31772684	Disease markers	2019	Circular RNAs Hsa_circ_0002715 and Hsa_circ_0035197 in Peripheral Blood Are Novel Potential Biomarkers for New-Onset Rheumatoid Arthritis.	hsa_circ_0002715		hsa_circ_PCNT	PCNT	new-onset rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"hsa_circ_0002715 is up-regulated in peripheral blood of new-onset RA patients and shows diagnostic value versus controls and other autoimmune/arthritic groups. Its expression correlates with RA activity-related clinical indices, and predicted miRNA targets suggest a potential miRNA-sponge role."	0.459
31772684	Disease markers	2019	Circular RNAs Hsa_circ_0002715 and Hsa_circ_0035197 in Peripheral Blood Are Novel Potential Biomarkers for New-Onset Rheumatoid Arthritis.	hsa_circ_0035197		hsa_circ_ATP8B4	ATP8B4	new-onset rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"hsa_circ_0035197 is up-regulated in peripheral blood of new-onset RA patients and has diagnostic value versus healthy controls and other disease groups including UA. It is implicated as a biomarker potentially associated with hematological involvement, and predicted miRNA targets suggest a possible miRNA-sponge role."	0.459
31772684	Disease markers	2019	Circular RNAs Hsa_circ_0002715 and Hsa_circ_0035197 in Peripheral Blood Are Novel Potential Biomarkers for New-Onset Rheumatoid Arthritis.	hsa_circ_0001947		hsa_circ_AFF2	AFF2	new-onset rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"hsa_circ_0001947 is up-regulated in peripheral blood of new-onset RA patients and can differentiate RA from controls and comparator disease groups including UA. It is linked to ACPA positivity and other hematological parameters, and predicted miRNA targets indicate a potential miRNA-sponge role."	0.459
31772684	Disease markers	2019	Circular RNAs Hsa_circ_0002715 and Hsa_circ_0035197 in Peripheral Blood Are Novel Potential Biomarkers for New-Onset Rheumatoid Arthritis.	hsa_circ_0000367		hsa_circ_SIAE	SIAE	new-onset rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	hsa_circ_0000367 is up-regulated in peripheral blood of new-onset RA patients and shows diagnostic value versus HC/AS/SLE. Predicted miRNA targets suggest a potential miRNA-sponge role; host gene is reported as SIAE.	0.459
31775754	BMC medical genomics	2019	High-throughput RNA sequencing from paired lesional- and non-lesional skin reveals major alterations in the psoriasis circRNAome.		ciRS-7 / CDR1as	hsa_circ_CDR1AS	CDR1-AS	psoriasis 	MONDO:0005083	psoriasis	down-regulated	ISH; RNA-seq	"ciRS-7 (CDR1as) is significantly down-regulated in lesional psoriatic skin, particularly in the epidermis. The study assessed circRNA_miRNA binding-site changes genome-wide and did not find evidence that circRNAome changes (including ciRS-7 reduction) explain miRNA expression differences between lesional and non-lesional skin."	0.4032
31775841	Reproductive biology and endocrinology : RB&E	2019	CircRNA expression profile and functional analysis in testicular tissue of patients with non-obstructive azoospermia.	hsa_circ_0058058				non-obstructive azoospermia 	MONDO:0100459	azoospermia	up-regulated	RT-qPCR; Microarray	"hsa_circ_0058058 is significantly up-regulated in testicular tissue from NOA patients versus OA controls, validated by qRT-PCR."	0.3588
31775841	Reproductive biology and endocrinology : RB&E	2019	CircRNA expression profile and functional analysis in testicular tissue of patients with non-obstructive azoospermia.	hsa_circ_0008045				non-obstructive azoospermia 	MONDO:0100459	azoospermia	up-regulated	RT-qPCR; Microarray	"hsa_circ_0008045 is significantly up-regulated in testicular tissue from NOA patients versus OA controls, validated by qRT-qPCR."	0.3588
31775841	Reproductive biology and endocrinology : RB&E	2019	CircRNA expression profile and functional analysis in testicular tissue of patients with non-obstructive azoospermia.	hsa_circ_0023313				non-obstructive azoospermia 	MONDO:0100459	azoospermia	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_0023313 is up-regulated in NOA testicular tissue and was selected for downstream bioinformatics analyses. It is predicted to act as a miRNA sponge (e.g., miR-372-3p and miR-373-3p) in a circRNA/miRNA/mRNA ceRNA network potentially involving genes such as RAB-24 and USP24, with enrichment in pathways including meiosis, FoxO signaling, ubiquitin mediated proteolysis and AMPK signaling."	0.4032
31775841	Reproductive biology and endocrinology : RB&E	2019	CircRNA expression profile and functional analysis in testicular tissue of patients with non-obstructive azoospermia.	hsa_circ_0002023				non-obstructive azoospermia 	MONDO:0100459	azoospermia	down-regulated	RT-qPCR; Microarray	"hsa_circ_0002023 is significantly down-regulated in NOA testicular tissue compared with OA controls, validated by qRT-PCR."	0.3588
31775841	Reproductive biology and endocrinology : RB&E	2019	CircRNA expression profile and functional analysis in testicular tissue of patients with non-obstructive azoospermia.	hsa_circ_0008533				non-obstructive azoospermia 	MONDO:0100459	azoospermia	down-regulated	RT-qPCR; Microarray	"hsa_circ_0008533 is significantly down-regulated in NOA testicular tissue compared with OA controls, validated by qRT-PCR."	0.3588
31776329	Cell death & disease	2019	CircRNA-5692 inhibits the progression of hepatocellular carcinoma by sponging miR-328-5p to enhance DAB2IP expression.	hsa_circ_0005692	CircRNA-5692	hsa_circ_GLIS2	GLIS2	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"circRNA-5692 is down-regulated in hepatocellular carcinoma and functions as a tumor suppressor. It inhibits proliferation, migration/wound healing, invasion, EMT, and xenograft tumor growth while promoting apoptosis, mainly by sponging miR-328-5p to increase DAB2IP expression."	0.73
31776711	Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association	2020	CircDUSP16 promotes the tumorigenesis and invasion of gastric cancer by sponging miR-145-5p.	hsa_circ_0003855	circDUSP16	hsa_circ_DUSP16	DUSP16	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; ISH; Microarray	"circDUSP16 (hsa_circ_0003855), derived from DUSP16, is up-regulated in gastric cancer tissues and primarily localized in the cytoplasm. It promotes GC cell proliferation/viability, colony formation, invasion, and xenograft tumor growth by sponging miR-145-5p, thereby relieving repression of IVNS1ABP. High circDUSP16 expression predicts poorer overall survival and is an independent prognostic factor in GC."	0.8655
31778958	Molecular therapy. Nucleic acids	2019	Suppression of circDcbld1 Alleviates Intimal Hyperplasia in Rat Carotid Artery by Targeting miR-145-3p/Neuropilin-1.		rno-circRNA_009723	rno_circ_Dcbld1	Dcbld1	intimal hyperplasia 	MONDO:0005043	hyperplasia	up-regulated	RT-qPCR; Microarray	"circDcbld1 (rno-circRNA_009723) is up-regulated in balloon-injured rat carotid arteries with intimal hyperplasia and localizes mainly to the cytoplasm. It promotes VSMC migration and neointimal formation by acting as a ceRNA that sponges miR-145-3p, thereby de-repressing/upregulating Nrp1; circDcbld1 knockdown reduces neuropilin-1 and alleviates intimal hyperplasia in vivo."	0.7654
31781492	Frontiers in oncology	2019	Circular RNA-Associated Competing Endogenous RNA Network and Prognostic Nomogram for Patients With Colorectal Cancer.		hsa_circ_00001666			colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RNA-seq	"This study suggests that hsa_circ_00001666 is down-regulated in colorectal cancer and may participate in CRC pathogenesis via a ceRNA axis involving has-mir-1229 and CXCR5. The conclusion is based on public GEO/TCGA datasets and interaction predictions, without experimental validation."	0.1768
31782248	Journal of cellular and molecular medicine	2020	CircNr1h4 regulates the pathological process of renal injury in salt-sensitive hypertensive mice by targeting miR-155-5p.		circRNA1350	mmu_circ_Nr1h4	Nr1h4	hypertensive renal injury 	MONDO:0001105	renal hypertension	down-regulated	RT-qPCR; RNA-seq	"In DOCA-salt-induced hypertensive renal injury in mice, circNr1h4 (circRNA1350) is significantly down-regulated in injured kidney. It functions as a ceRNA/miRNA sponge for miR-155-5p to relieve repression of Far1, thereby influencing Far1 levels and renal oxidative stress (ROS)."	0.7211
31782868	Cancer science	2020	Circular RNA hsa_circ_001895 serves as a sponge of microRNA-296-5p to promote clear cell renal cell carcinoma progression by regulating SOX12.		hsa_circ_001895	hsa_circ_CTBP1	CTBP1	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR; ISH	"hsa_circ_001895 is up-regulated in ccRCC tissues and cell lines and mainly localizes to the cytoplasm. It promotes ccRCC proliferation, migration/invasion, cell-cycle progression and xenograft growth while inhibiting apoptosis, primarily by sponging miR-296-5p to upregulate SOX12."	0.8526
31786335	Molecular therapy. Nucleic acids	2019	Whole-Transcriptome Analysis of APP/PS1 Mouse Brain and Identification of circRNA-miRNA-mRNA Networks to Investigate AD Pathogenesis.	mmu_circ_0000433				Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	dysregulated	RNA-seq	"mmu_circ_0000433 was identified in APP/PS1 mouse brain as a dysregulated circRNA participating in a predicted ceRNA network. It may sponge mmu-miR-122b-3p, thereby relating to regulation of the AD-associated target gene Cntnap2."	0.4851
31786335	Molecular therapy. Nucleic acids	2019	Whole-Transcriptome Analysis of APP/PS1 Mouse Brain and Identification of circRNA-miRNA-mRNA Networks to Investigate AD Pathogenesis.	mmu_circ_0001473				Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	dysregulated	RNA-seq	mmu_circ_0001473 was identified in APP/PS1 mouse brain as a dysregulated circRNA within a predicted ceRNA network. It may function by sponging mmu-miR-122b-3p and is linked to regulation of Cntnap2 in the AD model context.	0.4851
31786335	Molecular therapy. Nucleic acids	2019	Whole-Transcriptome Analysis of APP/PS1 Mouse Brain and Identification of circRNA-miRNA-mRNA Networks to Investigate AD Pathogenesis.	mmu_circ_0044900				Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	dysregulated	RNA-seq	"mmu_circ_0044900 was identified as a dysregulated circRNA in APP/PS1 mouse brain and predicted to function as a ceRNA. It may sponge mmu-miR-449a-5p/mmu-miR-467a-3p/mmu-miR-540-3p/mmu-miR-669f-3p to affect the target gene Creb, linking it to inflammation-related regulation in the AD model."	0.4851
31786335	Molecular therapy. Nucleic acids	2019	Whole-Transcriptome Analysis of APP/PS1 Mouse Brain and Identification of circRNA-miRNA-mRNA Networks to Investigate AD Pathogenesis.	mmu_circ_0000452				Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	dysregulated	RNA-seq	"mmu_circ_0000452 was highlighted as part of an AD-relevant predicted ceRNA network in APP/PS1 mouse brain. It was suggested to bind mmu-miR-466b-5p, which targets Scube2, a gene described as critical for AD progression."	0.4851
31786335	Molecular therapy. Nucleic acids	2019	Whole-Transcriptome Analysis of APP/PS1 Mouse Brain and Identification of circRNA-miRNA-mRNA Networks to Investigate AD Pathogenesis.	mmu_circ_0000453				Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	dysregulated	RNA-seq	"mmu_circ_0000453 was suggested to participate in an AD-related ceRNA network in APP/PS1 mouse brain. It may bind mmu-miR-466b-5p and relate to regulation of the target gene Scube2, which the paper describes as critical for AD progression."	0.4851
31790973	Molecular therapy. Nucleic acids	2020	Characterization of Circular RNAs in Vascular Smooth Muscle Cells with Vascular Calcification.		circSamd4a	rno_circ_Samd4a	Samd4a	vascular calcification 	MONDO:0005311	atherosclerosis	down-regulated	RT-qPCR; RNA-seq	"circSamd4a is down-regulated during phosphate-induced vascular calcification in rat VSMCs and functions as an anti-calcification circRNA. It localizes mainly in the cytoplasm and acts as a ceRNA/miRNA sponge for miR-125a-3p and miR-483-5p, thereby modulating downstream targets including Camsap2 and Flna to reduce calcium deposition."	0.7566
31790973	Molecular therapy. Nucleic acids	2020	Characterization of Circular RNAs in Vascular Smooth Muscle Cells with Vascular Calcification.		circSmoc1-1	rno_circ_Smoc1	Smoc1	vascular calcification 	MONDO:0005311	atherosclerosis	down-regulated	RT-qPCR; RNA-seq	"circSmoc1-1 is down-regulated during phosphate-induced vascular calcification in rat VSMCs and was validated as a circular RNA (RNase R resistance, BSJ sequence confirmation) with mainly cytoplasmic localization. Functional effects on calcification were not demonstrated in this study."	0.5064
31790973	Molecular therapy. Nucleic acids	2020	Characterization of Circular RNAs in Vascular Smooth Muscle Cells with Vascular Calcification.		circMettl9	rno_circ_Mettl9	Mettl9	vascular calcification 	MONDO:0005311	atherosclerosis	down-regulated	RT-qPCR; RNA-seq	"circMettl9 is down-regulated during phosphate-induced vascular calcification in rat VSMCs and was experimentally characterized as a circRNA (RT-PCR validation, RNase R resistance, and back-splice junction sequence confirmation). However, no direct functional impact on calcification was established in this work."	0.5064
31793989	Bioscience reports	2019	Circular RNA circ-PVT1 contributes to paclitaxel resistance of gastric cancer cells through the regulation of ZEB1 expression by sponging miR-124-3p.			hsa_circ_PVT1	PVT1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ-PVT1 is up-regulated in paclitaxel-resistant gastric cancer tissues and cells. It promotes PTX resistance by sponging miR-124-3p and thereby increasing ZEB1 expression; circ-PVT1 knockdown restores PTX sensitivity and enhances PTX-induced apoptosis while reducing invasion, including in xenograft models."	0.6536
31797949	Scientific reports	2019	A novel circRNA-miRNA-mRNA network identifies circ-YOD1 as a biomarker for coronary artery disease.	hsa_circ_0016274		hsa_circ_YOD1	YOD1	coronary artery disease 	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR; Microarray	"circ-YOD1 is up-regulated in peripheral blood/plasma of CAD patients and shows diagnostic value by ROC analysis (AUC 0.824). Functional experiments in THP-1 cells and HASMCs suggest a ceRNA role where circ-YOD1 negatively regulates miR-21-3p and miR-296-3p and increases expression of downstream target genes (e.g., BCL6, FBXL18, MMP9, FCGR3B)."	0.7113
31798828	Cell & bioscience	2019	Hsa_circ_0051079 functions as an oncogene by regulating miR-26a-5p/TGF-beta1 in osteosarcoma.	hsa_circ_0051079				osteosarcoma	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"circ_0051079 is up-regulated in osteosarcoma tissues and patient serum and functions as an oncogenic circRNA. It promotes proliferation and metastasis-related behaviors by sponging miR-26a-5p, thereby relieving repression of TGF-beta1 and activating TGF-beta signaling. High circ_0051079 expression is associated with shorter overall survival and may serve as a diagnostic biomarker."	0.7373
31798828	Cell & bioscience	2019	Hsa_circ_0051079 functions as an oncogene by regulating miR-26a-5p/TGF-beta1 in osteosarcoma.		Circ_0011038			osteosarcoma	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	circ_0011038 was identified by microarray screening and validated by RT-qPCR as significantly up-regulated in osteosarcoma tissues versus adjacent normal tissues. No functional or mechanistic characterization was reported for this circRNA in the study.	0.3588
31798828	Cell & bioscience	2019	Hsa_circ_0051079 functions as an oncogene by regulating miR-26a-5p/TGF-beta1 in osteosarcoma.		Circ_0070372			osteosarcoma	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; Microarray	circ_0070372 was identified by microarray screening and validated by RT-qPCR as down-regulated in osteosarcoma tissues versus adjacent normal tissues. The study did not further investigate its functional role or mechanism.	0.3588
31798828	Cell & bioscience	2019	Hsa_circ_0051079 functions as an oncogene by regulating miR-26a-5p/TGF-beta1 in osteosarcoma.		Circ_0035114			osteosarcoma	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; Microarray	"circ_0035114 was identified by microarray screening and validated by RT-qPCR as down-regulated in osteosarcoma tissues versus adjacent normal tissues. The study did not further explore its biological function, mechanism, or clinical relevance."	0.3588
31802888	OncoTargets and therapy	2019	Circular RNA circ-Foxo3 induced cell apoptosis in urothelial carcinoma via interaction with miR-191-5p.			hsa_circ_FOXO3	FOXO3	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR	"circ-Foxo3 is down-regulated in bladder cancer tissues and cell lines. Its overexpression promotes apoptosis and decreases viability of bladder cancer cells, and miR-191-5p directly binds the circ-Foxo3 3_-UTR to suppress circ-Foxo3 expression and its pro-apoptotic effect."	0.6542
31803627	Frontiers in oncology	2019	hsa_circ_0007841: A Novel Potential Biomarker and Drug Resistance for Multiple Myeloma.	hsa_circ_0007841		hsa_circ_SEC61A1	sec61a1	multiple myeloma 	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0007841 is significantly up-regulated in multiple myeloma bone marrow samples and MM/drug-resistant cell lines. High expression is associated with bortezomib resistance and poorer progression-free survival, and it shows diagnostic potential (ROC AUC ~0.91). Mechanistically, it is proposed to act via a predicted circRNA_miRNA_mRNA network, including sponging hsa-miR-29b-2-5p and hsa-miR-199a-3p."	0.5534
31807009	OncoTargets and therapy	2019	Emerging Roles Of hsa-circ-0046600 Targeting The miR-640/HIF-1alpha Signalling Pathway In The Progression Of HCC.	hsa_circ_0046600		hsa_circ_B3GNTL1	B3GNTL1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"hsa-circ-0046600 is up-regulated in HCC tissues/cell lines and promotes HCC cell migration. It mainly localizes to the cytoplasm and functions as a miR-640 sponge to increase HIF-1alpha (and migration-related N-cadherin) expression, supporting a hsa-circ-0046600/miR-640/HIF-1alpha axis."	0.7791
31807029	OncoTargets and therapy	2019	circ_0003418 Inhibits Tumorigenesis And Cisplatin Chemoresistance Through Wnt/beta-Catenin Pathway In Hepatocellular Carcinoma.	hsa_circ_0003418				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"circ_0003418 is down-regulated in HCC tissues and cell lines and acts as a tumor suppressor. Its knockdown promotes proliferation/migration/invasion and increases cisplatin resistance, partly by activating Wnt/beta-catenin signaling (beta-catenin and c-Myc), while Wnt/beta-catenin inhibition reverses these effects."	0.5414
31808751	Aging	2019	circ5912 suppresses cancer progression via inducing MET in bladder cancer.	hsa_circ_0005912	circ5912	hsa_circ_FIP1L1	FIP1L1	bladder cancer	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"circ5912 (hsa_circ_0005912) is down-regulated in bladder cancer tissues and higher levels associate with better clinicopathological features and longer overall survival. Functionally, circ5912 suppresses bladder cancer cell proliferation/viability, migration and invasion, inhibits TGF-beta2-induced EMT and promotes MET, and reduces xenograft tumor growth."	0.8583
31811527	GeroScience	2020	"circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan."		circDEF6	hsa_circ_DEF6	DEF6	human aging phenotypes 			unknown	RT-qPCR; RNA-seq	"In human peripheral blood from the InCHIANTI aging cohort, circDEF6 expression showed a nominal positive association with parental longevity score, suggesting potential relevance to human aging phenotypes."	0.5466
31811527	GeroScience	2020	"circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan."		circEP300	hsa_circ_EP300	EP300	human aging phenotypes 			dysregulated	RT-qPCR; RNA-seq	"circEP300 in human peripheral blood was negatively associated with parental longevity score and was also differentially expressed in senescent primary human cell types, linking it to aging-related phenotypes and cellular senescence."	0.5466
31811527	GeroScience	2020	"circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan."		circFOXO3	hsa_circ_FOXO3	FOXO3	human aging phenotypes 			dysregulated	RT-qPCR; RNA-seq	"circFOXO3 was associated with human parental longevity score and showed dysregulated expression in senescent primary human cell types, implicating it in aging-related phenotypes and cellular senescence."	0.5466
31811527	GeroScience	2020	"circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan."		circFNDC3B	hsa_circ_FNDC3B	FNDC3B	human aging phenotypes 			unknown	RT-qPCR; RNA-seq	"In the InCHIANTI cohort, peripheral blood circFNDC3B levels were nominally positively associated with hand grip strength (both cross-sectionally and longitudinally), linking it to aging-related functional phenotypes."	0.5466
31811527	GeroScience	2020	"circRNAs expressed in human peripheral blood are associated with human aging phenotypes, cellular senescence and mouse lifespan."		circPlekhm1	mmu_circ_Plekhm1	Plekhm1	mouse lifespan 			unknown	RT-qPCR	"In mice, circPlekhm1 expression (measured by RT-qPCR) showed a nominal positive association with median strain lifespan, particularly in spleen, suggesting a potential link between circPlekhm1 levels and longevity."	0.31
31812104	Molecular therapy. Nucleic acids	2020	circAMOTL1 Motivates AMOTL1 Expression to Facilitate Cervical Cancer Growth.	hsa_circ_0004214		hsa_circ_AMOTL1	AMOTL1	cervical cancer	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Northern Blot	"circAMOTL1 (hsa_circ_0004214) is upregulated in cervical cancer and correlates with poorer overall survival. Functionally, it promotes proliferation and migration in cervical cancer cells and accelerates xenograft tumor growth. Mechanistically, circAMOTL1 acts as a ceRNA that sponges miR-485-5p to upregulate AMOTL1."	0.892
31814763	Cancer management and research	2019	Downregulated Circular RNA hsa_circ_0000291 Suppresses Migration And Proliferation Of Gastric Cancer Via Targeting The miR-183/ITGB1 Axis.	hsa_circ_0000291		hsa_circ_CD44	CD44	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; ISH	"hsa_circ_0000291 is up-regulated in gastric cancer tissues and cell lines and promotes proliferation and metastasis/migration. Mechanistically, it sponges miR-183 to increase ITGB1 expression, and knockdown of hsa_circ_0000291 suppresses tumor growth and metastasis in vitro and in nude-mouse xenograft models."	0.5997
31815137	BioMed research international	2019	Identification of Circular RNAs Regulating Islet beta-Cell Autophagy in Type 2 Diabetes Mellitus.		rno_circRNA_011190			type 2 diabetes mellitus 	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RT-qPCR; Microarray	"rno_circRNA_011190 is up-regulated in islet beta-cells from T2DM rats versus controls, identified by circRNA microarray and validated by RT-qPCR. The study did not report a specific miRNA/mRNA mechanism for this circRNA."	0.4997
31815137	BioMed research international	2019	Identification of Circular RNAs Regulating Islet beta-Cell Autophagy in Type 2 Diabetes Mellitus.		rno_circRNA_014301			type 2 diabetes mellitus 	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RT-qPCR; Microarray	"rno_circRNA_014301 is up-regulated in islet beta-cells from T2DM rats versus controls, supported by microarray and validated by RT-qPCR. No specific downstream miRNA/mRNA axis was reported for this circRNA."	0.4997
31815137	BioMed research international	2019	Identification of Circular RNAs Regulating Islet beta-Cell Autophagy in Type 2 Diabetes Mellitus.		rno_circRNA_000793			type 2 diabetes mellitus 	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RT-qPCR; Microarray	"rno_circRNA_000793 is up-regulated in islet beta-cells of T2DM rats, validated by RT-qPCR. It was included in a predicted circRNA/miRNA interaction network, but specific miRNA partners and functional effects were not detailed in the provided text."	0.4997
31815137	BioMed research international	2019	Identification of Circular RNAs Regulating Islet beta-Cell Autophagy in Type 2 Diabetes Mellitus.		mmu_circRNA_31436			type 2 diabetes mellitus 	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RT-qPCR; Microarray	mmu_circRNA_31436 is up-regulated in islet beta-cells from T2DM rats versus controls and was among the circRNAs validated by RT-qPCR. The provided text does not specify its miRNA targets or mechanistic role in beta-cell autophagy.	0.4997
31815137	BioMed research international	2019	Identification of Circular RNAs Regulating Islet beta-Cell Autophagy in Type 2 Diabetes Mellitus.		rno_circRNA_008695			type 2 diabetes mellitus 	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RT-qPCR; Microarray	"rno_circRNA_008695 is up-regulated in islet beta-cells of T2DM rats and validated by RT-qPCR. It was included in a predicted circRNA/miRNA network, but specific miRNA interactions or autophagy-related functions were not specified for this circRNA in the provided text."	0.4997
31815137	BioMed research international	2019	Identification of Circular RNAs Regulating Islet beta-Cell Autophagy in Type 2 Diabetes Mellitus.		rno_circRNA_001731			type 2 diabetes mellitus 	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RT-qPCR; Microarray	rno_circRNA_001731 is down-regulated in islet beta-cells from T2DM rats and was validated by RT-qPCR. The study did not provide a specific autophagy-related mechanism for this circRNA in the provided text.	0.4997
31815137	BioMed research international	2019	Identification of Circular RNAs Regulating Islet beta-Cell Autophagy in Type 2 Diabetes Mellitus.		rno_circRNA_017447			type 2 diabetes mellitus 	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RT-qPCR; Microarray	rno_circRNA_017447 is down-regulated in islet beta-cells from T2DM rats and was validated by RT-qPCR. No specific autophagy mechanism was provided for this circRNA in the available text.	0.4997
31815137	BioMed research international	2019	Identification of Circular RNAs Regulating Islet beta-Cell Autophagy in Type 2 Diabetes Mellitus.		rno_circRNA_008565			type 2 diabetes mellitus 	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RT-qPCR; Microarray	"rno_circRNA_008565 is down-regulated in islet beta-cells of T2DM rats and was validated by RT-qPCR. Bioinformatic analyses suggest it may regulate beta-cell autophagy through miRNA binding (notably rno-miR-504) and potential downstream targets including MAPK8 (JNK), implicating MAPK-related autophagy regulation."	0.4997
31815137	BioMed research international	2019	Identification of Circular RNAs Regulating Islet beta-Cell Autophagy in Type 2 Diabetes Mellitus.		rno_circRNA_011560			type 2 diabetes mellitus 	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RT-qPCR; Microarray	rno_circRNA_011560 is down-regulated in islet beta-cells from T2DM rats and was validated by RT-qPCR. The provided text does not report its miRNA partners or autophagy-related mechanism.	0.4997
31815137	BioMed research international	2019	Identification of Circular RNAs Regulating Islet beta-Cell Autophagy in Type 2 Diabetes Mellitus.		mmu_circRNA_24828			type 2 diabetes mellitus 	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_24828 is down-regulated in islet beta-cells from T2DM rats and validated by RT-qPCR. It was included among circRNAs whose predicted target genes were analyzed for association with beta-cell autophagy (e.g., CSF1, MAPK9, MAPT)."	0.4997
31815619	Molecular cancer	2019	Circular RNA circFGFR1 promotes progression and anti-PD-1 resistance by sponging miR-381-3p in non-small cell lung cancer cells.	hsa_circ_0084003	circFGFR1	hsa_circ_FGFR1	FGFR1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circFGFR1 is up-regulated in NSCLC tissues and promotes proliferation, migration/invasion, metastasis-related phenotypes, and immune evasion. It functions as a ceRNA by sponging miR-381-3p to increase CXCR4 expression, contributing to resistance to anti-PD-1 therapy and poorer patient prognosis."	0.8168
31818729	Turkish journal of haematology : official journal of Turkish Society of Haematology	2020	"Expression Profile Screening and Bioinformatics Analysis of circRNA, LncRNA, and mRNA in Acute Myeloid Leukemia Drug-Resistant Cells."	hsa_circ_0000978				acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	unknown	RT-qPCR; RNA-seq	"This study profiled circRNAs in adriamycin-resistant AML cells and highlighted Hsa-circ-0000978 as a circRNA potentially relevant to AML drug resistance, proposed as a prognostic biomarker and therapeutic target. The work supports a circRNA_miRNA (ceRNA-related) regulatory context but does not report a specific miRNA/mRNA axis for this circRNA in the provided text."	0.2465
31818729	Turkish journal of haematology : official journal of Turkish Society of Haematology	2020	"Expression Profile Screening and Bioinformatics Analysis of circRNA, LncRNA, and mRNA in Acute Myeloid Leukemia Drug-Resistant Cells."	hsa_circ_0000483				acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	unknown	RT-qPCR; RNA-seq	"This study profiled circRNAs in adriamycin-resistant AML cells and highlighted hsa-circ-0000483 as a circRNA potentially relevant to AML drug resistance, proposed as a prognostic biomarker and therapeutic target. The work supports a circRNA_miRNA (ceRNA-related) regulatory context but does not report a specific miRNA/mRNA axis for this circRNA in the provided text."	0.2465
31819015	Aging	2019	ciRs-6 upregulates March1 to suppress bladder cancer growth by sponging miR-653.	hsa_circ_0006260	ciRs-6	hsa_circ_SLC41A2	SLC41A2	bladder cancer	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"ciRs-6 is down-regulated in bladder cancer and acts as a tumor suppressor by sponging miR-653 in the cytoplasm, thereby relieving repression of March1. Higher ciRs-6 expression is associated with better overall survival and less advanced clinicopathologic features."	0.8702
31819016	Aging	2019	Posttranscriptional regulation of AKT by circular RNA angiomotin- like 1 mediates chemoresistance against paclitaxel in breast cancer cells.		circular angiomotin-like 1	hsa_circ_AMOTL1	AMOTL1	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circAMOTL1 increases paclitaxel resistance in triple-negative breast cancer cells by binding to phosphorylated AKT and elevating total/phosphorylated AKT levels. It shifts apoptosis regulators (BCL2 up, BAX/BAK down), thereby promoting survival and invasion under paclitaxel treatment."	0.6718
31819492	OncoTargets and therapy	2019	circ-MYBL2 Serves As A Sponge For miR-361-3p Promoting Cervical Cancer Cells Proliferation And Invasion.	hsa_circ_0060467		hsa_circ_MYBL2	MYBL2	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ-MYBL2 (hsa_circ_0060467) is up-regulated in cervical cancer and promotes malignant phenotypes (proliferation, invasion, EMT). Mechanistically, it functions as a sponge for miR-361-3p, and miR-361-3p inhibition rescues the effects of circ-MYBL2 knockdown. High circ-MYBL2 expression is associated with advanced clinical features and poor prognosis."	0.7537
31819492	OncoTargets and therapy	2019	circ-MYBL2 Serves As A Sponge For miR-361-3p Promoting Cervical Cancer Cells Proliferation And Invasion.	hsa_circ_0060458				cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"has_circ_0060458 was found to be up-regulated in cervical cancer tissues versus adjacent normal tissues in an initial qRT-PCR screen, but no functional or mechanistic experiments were reported for it in this study."	0.2995
31819492	OncoTargets and therapy	2019	circ-MYBL2 Serves As A Sponge For miR-361-3p Promoting Cervical Cancer Cells Proliferation And Invasion.	hsa_circ_0090531				cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"has_circ_0090531 was detected as up-regulated in cervical cancer tissues versus adjacent normal tissues in an initial qRT-PCR screen, but was not further characterized functionally or mechanistically in this study."	0.2995
31819653	Cancer management and research	2019	CircCDYL Serves as a New Biomarker in Mantle Cell Lymphoma and Promotes Cell Proliferation.		circ-chromodomain Y-like	hsa_circ_CDYL	CDYL	mantle cell lymphoma 	MONDO:0018876	mantle cell lymphoma	up-regulated	RT-qPCR	"circCDYL is up-regulated in the plasma of mantle cell lymphoma patients and shows diagnostic potential (AUC 0.856). Functionally, circCDYL promotes proliferation of MCL Z138 cells, since circCDYL knockdown suppresses proliferation. The proposed mechanism is a bioinformatically predicted circCDYL_miRNA_mRNA/lncRNA regulatory network involving five highlighted miRNAs and targets including NOTCH1, ABCB1, TWIST1 and VEGFA."	0.6422
31821171	Aging	2019	CircPTPRA acts as a tumor suppressor in bladder cancer by sponging miR-636 and upregulating KLF9.	hsa_circ_0006117	circPTPRA	hsa_circ_PTPRA	PTPRA	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR	"circPTPRA is down-regulated in bladder cancer and functions as a tumor suppressor. It mainly localizes in the cytoplasm and acts as a ceRNA that sponges miR-636, thereby relieving repression of KLF9 and inhibiting bladder cancer cell proliferation and xenograft tumor growth. Low circPTPRA expression is associated with poor prognosis and more advanced disease features."	0.8806
31822654	Cell death & disease	2019	Circ_0001955 facilitates hepatocellular carcinoma (HCC) tumorigenesis by sponging miR-516a-5p to release TRAF6 and MAPK11.	hsa_circ_0001955		hsa_circ_CSNK1G1	CSNK1G1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0001955 is upregulated in HCC tissues and patient serum and functions as an oncogenic circRNA. It sponges miR-516a-5p (also predicted/implicated with miR-145-5p), thereby relieving repression of TRAF6 and MAPK11 and promoting HCC cell proliferation and xenograft tumor growth."	0.8267
31827402	Cancer cell international	2019	Circular RNA ITCH suppressed prostate cancer progression by increasing HOXB13 expression via spongy miR-17-5p.		Circular RNA Itchy E3 ubiquitin protein ligase	hsa_circ_ITCH	ITCH	prostate cancer 	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR	"CircITCH is down-regulated in prostate cancer tissues and cell lines. Functionally, circITCH overexpression suppresses proliferation/colony formation and promotes apoptosis in vitro and inhibits tumor growth in xenografts, mainly by sponging miR-17-5p to upregulate HOXB13."	0.7412
31827632	Disease markers	2019	Downregulated Expression of hsa_circ_0005556 in Gastric Cancer and Its Clinical Significance.	hsa_circ_0005556		hsa_circ_NBAS	NBAS	Gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"hsa_circ_0005556 is significantly down-regulated in gastric cancer tissues and shows diagnostic potential (ROC AUC 0.773). Higher tumor hsa_circ_0005556 levels are associated with longer overall survival, and its expression correlates with differentiation, TNM stage, and lymphatic metastasis. A miRNA-sponge (ceRNA) role is proposed based on bioinformatic prediction but not experimentally validated."	0.6355
31827647	Disease markers	2019	Expression Profile Analysis of Differentially Expressed Circular RNAs in Steroid-Induced Osteonecrosis of the Femoral Head.	hsa_circ_0140628	circATP7A_020	hsa_circ_ATP7A	ATP7A	steroid-induced osteonecrosis of the femoral head 	MONDO:0005380	osteonecrosis	up-regulated	RT-qPCR; RNA-seq	circ_0140628 (circATP7A_020) is up-regulated in peripheral blood of SONFH patients and was included in a predicted circRNA_miRNA_mRNA interaction network (miR-433-5p as a putative binding miRNA).	0.4685
31827647	Disease markers	2019	Expression Profile Analysis of Differentially Expressed Circular RNAs in Steroid-Induced Osteonecrosis of the Femoral Head.	hsa_circ_0097391	circC12orf51_085	hsa_circ_HECTD4	HECTD4	steroid-induced osteonecrosis of the femoral head 	MONDO:0005380	osteonecrosis	up-regulated	RT-qPCR; RNA-seq	"circ_0097391 (circC12orf51_085) is up-regulated in peripheral blood of SONFH patients and was incorporated into a predicted circRNA_miRNA_mRNA network, with miR-221-3p as a putative interacting miRNA."	0.4685
31827647	Disease markers	2019	Expression Profile Analysis of Differentially Expressed Circular RNAs in Steroid-Induced Osteonecrosis of the Femoral Head.	hsa_circ_0058919	circNDUFA10_006	hsa_circ_NDUFA10	NDUFA10	steroid-induced osteonecrosis of the femoral head 	MONDO:0005380	osteonecrosis	up-regulated	RT-qPCR; RNA-seq	"circ_0058919 (circNDUFA10_006) is up-regulated in peripheral blood of SONFH patients and was analyzed bioinformatically within a predicted circRNA_miRNA_mRNA network, with miR-3663-3p as a putative interacting miRNA."	0.4685
31827647	Disease markers	2019	Expression Profile Analysis of Differentially Expressed Circular RNAs in Steroid-Induced Osteonecrosis of the Femoral Head.	hsa_circ_0002737	circSARNP_002	hsa_circ_SARNP	SARNP	steroid-induced osteonecrosis of the femoral head 	MONDO:0005380	osteonecrosis	up-regulated	RT-qPCR; RNA-seq	"circ_0002737 (circSARNP_002) is up-regulated in peripheral blood of SONFH patients and was included in a predicted circRNA_miRNA_mRNA network, with miR-17-5p as a putative interacting miRNA."	0.4685
31827647	Disease markers	2019	Expression Profile Analysis of Differentially Expressed Circular RNAs in Steroid-Induced Osteonecrosis of the Femoral Head.	hsa_circ_0004692	circSETD2_057	hsa_circ_SETD2	SETD2	steroid-induced osteonecrosis of the femoral head 	MONDO:0005380	osteonecrosis	up-regulated	RT-qPCR; RNA-seq	circ_0004692 (circSETD2_057) is up-regulated in peripheral blood of SONFH patients; the study proposes a circ_0004692_hsa-miR-222-3p_SETD2 regulatory relationship based on network prediction.	0.4685
31827647	Disease markers	2019	Expression Profile Analysis of Differentially Expressed Circular RNAs in Steroid-Induced Osteonecrosis of the Femoral Head.	hsa_circ_0000069	circSTIL_025	hsa_circ_STIL	STIL	steroid-induced osteonecrosis of the femoral head 	MONDO:0005380	osteonecrosis	up-regulated	RT-qPCR; RNA-seq	circ_0000069 (circSTIL_025) is up-regulated in peripheral blood of SONFH patients and was validated by qRT-PCR; it was also part of the study¡¯s predicted circRNA_miRNA_mRNA network (miR-345-5p as a putative interacting miRNA).	0.4685
31827647	Disease markers	2019	Expression Profile Analysis of Differentially Expressed Circular RNAs in Steroid-Induced Osteonecrosis of the Femoral Head.	hsa_circ_0003344	circTMCC2_001	hsa_circ_TMCC2	TMCC2	steroid-induced osteonecrosis of the femoral head 	MONDO:0005380	osteonecrosis	up-regulated	RT-qPCR; RNA-seq	circ_0003344 (circTMCC2_001) is up-regulated in peripheral blood of SONFH patients and was validated by qRT-PCR; it was also included in the predicted circRNA_miRNA_mRNA network (miR-615-5p as a putative interacting miRNA).	0.4685
31827647	Disease markers	2019	Expression Profile Analysis of Differentially Expressed Circular RNAs in Steroid-Induced Osteonecrosis of the Femoral Head.	hsa_circ_0093677	circZFAND4_005	hsa_circ_ZFAND4	ZFAND4	steroid-induced osteonecrosis of the femoral head 	MONDO:0005380	osteonecrosis	up-regulated	RT-qPCR; RNA-seq	circ_0093677 (circZFAND4_005) is up-regulated in peripheral blood of SONFH patients and was validated by qRT-PCR; it was also included in the predicted circRNA_miRNA_mRNA network (miR-378_h as a putative interacting miRNA).	0.4685
31827769	Pulmonary circulation	2019	Elevated serum circ_0068481 levels as a potential diagnostic and prognostic indicator in idiopathic pulmonary arterial hypertension.	hsa_circ_0068481	circ_0068481	hsa_circ_ST6GAL1	ST6GAL1	idiopathic pulmonary arterial hypertension 	MONDO:0001999	idiopathic pulmonary arterial hypertension	up-regulated	RT-qPCR	"Serum circ_0068481 is up-regulated in IPAH and shows strong diagnostic performance by ROC analysis. Higher circ_0068481 levels are associated with right heart failure incidence and death, indicating worse prognosis and poorer clinical outcomes."	0.5918
31828106	BioMed research international	2019	Microarray Analysis For Expression Profiles of lncRNAs and circRNAs in Rat Liver after Brain-Dead Donor Liver Transplantation.		rno_circRNA_007609			liver injury after brain-dead donor liver transplantation 	MONDO:0700220	disease related to transplantation	dysregulated	Microarray	"rno_circRNA_007609 is differentially expressed in rat liver after BDDLT and was incorporated into a ceRNA network. It is predicted to act as a ceRNA for rno-miR-135a-5p, thereby relating to regulation of Atf3, Per2, and Mras in the context of liver injury after transplantation from brain-dead donors."	0.4375
31828106	BioMed research international	2019	Microarray Analysis For Expression Profiles of lncRNAs and circRNAs in Rat Liver after Brain-Dead Donor Liver Transplantation.		rno_circRNA_013693			liver injury after brain-dead donor liver transplantation 	MONDO:0700220	disease related to transplantation	dysregulated	Microarray	"rno_circRNA_013693 is differentially expressed in rat liver after BDDLT and was included in the predicted ceRNA network. It is predicted to function as a ceRNA for rno-miR-322-5p, linking it to regulation of Per2, Mapkapk3, and Trim59 in liver injury following transplantation from brain-dead donors."	0.4375
31831728	Cell death & disease	2019	The novel circCLK3/miR-320a/FoxM1 axis promotes cervical cancer progression.	hsa_circ_0104541		hsa_circ_CLK3	CLK3	cervical cancer	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; RNA-seq	"circCLK3 is up-regulated in cervical cancer and functions as an oncogenic circRNA. It mainly localizes to the cytoplasm and promotes proliferation, EMT, migration, invasion and in vivo growth/metastasis by sponging miR-320a to increase FoxM1 expression (circCLK3/miR-320a/FoxM1 axis). High circCLK3 expression is associated with aggressive clinicopathological features and poorer survival."	0.8812
31844042	Cell death & disease	2019	Hsa_circ_0002483 inhibited the progression and enhanced the Taxol sensitivity of non-small cell lung cancer by targeting miR-182-5p.	hsa_circ_0002483				non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"circ_0002483 is down-regulated in NSCLC tissues/cell lines and acts as a tumor suppressor by inhibiting proliferation and invasion. It enhances Taxol sensitivity by sponging miR-182-5p (and other miRNAs), thereby increasing GRB2/FOXO1/FOXO3 expression; higher circ_0002483 expression is associated with better patient prognosis."	0.8295
31844675	"Open medicine (Warsaw, Poland)"	2019	CircRNA-UCK2 Increased TET1 Inhibits Proliferation and Invasion of Prostate Cancer Cells Via Sponge MiRNA-767-5p.		hsa_circ_001357	hsa_circ_UCK2	UCK2	prostate cancer 	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR	"circUCK2 is down-regulated in enzalutamide-resistant prostate cancer cells and acts as a miRNA sponge for miR-767-5p, thereby increasing TET1 and suppressing proliferation and invasion. Overexpression of circUCK2 inhibits EnzR-C4-2 tumor growth in a mouse xenograft model."	0.6952
31845519	Molecular genetics & genomic medicine	2020	Circ_0000267 promotes gastric cancer progression via sponging MiR-503-5p and regulating HMGA2 expression.	hsa_circ_0000267				gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_0000267 is up-regulated in gastric cancer tissues and cell lines and is associated with larger tumor diameter and lymph node metastasis. Functionally, it promotes GC cell proliferation, migration/invasion and EMT by sponging miR-503-5p and increasing HMGA2 expression (circ_0000267/miR-503-5p/HMGA2 axis)."	0.7657
31851619	Aging	2019	CircRNA_100367 regulated the radiation sensitivity of esophageal squamous cell carcinomas through miR-217/Wnt3 pathway.	hsa_circ_0014879	hsa_circRNA_100367	hsa_circ_DCAF8	DCAF8	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circRNA_100367 is up-regulated in radioresistant ESCC cells and promotes radioresistance, proliferation and migration/EMT-like phenotypes. Mechanistically, it acts as a cytoplasmic sponge of miR-217, relieving repression of Wnt3 and enhancing Wnt/beta-catenin signaling; circRNA_100367 silencing increases radiosensitivity and suppresses xenograft growth under irradiation."	0.7767
31857500	Aging	2019	CircAHNAK1 inhibits proliferation and metastasis of triple-negative breast cancer by modulating miR-421 and RASA1.	hsa_circ_0000320		hsa_circ_AHNAK	AHNAK	triple negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	down-regulated	RT-qPCR; Microarray	"circAHNAK1 is down-regulated in TNBC and acts as a tumor-suppressive circRNA. It mainly localizes in the cytoplasm and functions as a ceRNA that sponges miR-421 to increase RASA1 expression, thereby inhibiting TNBC proliferation and metastasis and associating with better patient survival when highly expressed."	0.8718
31857645	Scientific reports	2019	hsa_circ_0006459 and hsa_circ_0015962 affect prognosis of Dengue fever.	hsa_circ_0015962		hsa_circ_RNPEP	RNPEP	Dengue fever 	MONDO:0005502	dengue disease	up-regulated	RT-qPCR; Microarray	"In PBMCs/leukocytes from dengue fever patients, hsa_circ_0015962 is up-regulated after effective treatment compared with pre-treatment. It directly binds miR-4683 and negatively regulates it, and its expression correlates positively with WBC and platelet indices, supporting its potential as a treatment-response/prognostic biomarker."	0.6616
31857645	Scientific reports	2019	hsa_circ_0006459 and hsa_circ_0015962 affect prognosis of Dengue fever.	hsa_circ_0006459		hsa_circ_GNAQ	GNAQ	Dengue fever 	MONDO:0005502	dengue disease	down-regulated	RT-qPCR; Microarray	"In PBMCs/leukocytes from dengue fever patients, hsa_circ_0006459 is down-regulated after effective treatment compared with pre-treatment. It binds miR-133b and negatively regulates it, and it is inversely correlated with WBC/platelet-related indices, supporting its potential as a treatment-response/prognostic biomarker."	0.6616
31860870	Aging	2019	Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice.	mmu_circ_0003411	circNF1-419	mmu_circ_NF1	NF1	Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR; RNA-seq	"In AD-like mice, circNF1-419 enhances autophagy and improves dementia-related pathology. Mechanistically, it localizes to the cytoplasm and binds Dynamin-1 and AP2B1, and is associated with modulation of PI3K/Akt/AMPK/mTOR signaling and reduced AD marker proteins (e.g., Tau/p-Tau/Abeta/APOE)."	0.7621
31862871	Cell death & disease	2019	Biosynthetic CircRNA_001160 induced by PTBP1 regulates the permeability of BTB via the CircRNA_001160/miR-195-5p/ETV1 axis.	hsa_circ_0001417		hsa_circ_ANKRD17	ANKRD17	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR; Northern Blot; ISH; Microarray	"circRNA_001160 (from ANKRD17) is up-regulated in glioma endothelial cells and decreases BTB permeability by maintaining tight-junction protein expression. Mechanistically, PTBP1 promotes its biogenesis, and circRNA_001160 sponges miR-195-5p to relieve repression of ETV1, which transcriptionally activates ZO-1/occludin/claudin-5. Targeting circRNA_001160 (e.g., knockdown) increases BTB permeability and can enhance doxorubicin passage in the in vitro BTB model."	0.7531
31863641	Molecular genetics & genomic medicine	2020	Circular RNA circ-CMPK1 contributes to cell proliferation of non-small cell lung cancer by elevating cyclin D1 via sponging miR-302e.	hsa_circ_0012384		hsa_circ_CMPK1	CMPK1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ-CMPK1 is up-regulated in NSCLC and promotes tumor cell proliferation and cell-cycle progression. Mechanistically, it acts as a ceRNA that sponges miR-302e, thereby increasing cyclin D1 (CCND1) expression and enhancing tumor growth, including in a xenograft model."	0.7353
31868205	Bioscience reports	2020	CircRNA circPDSS1 promotes bladder cancer by down-regulating miR-16.	hsa_circ_0093398		hsa_circ_PDSS1	PDSS1	urothelial bladder cancer 	MONDO:0005611	bladder transitional cell carcinoma	up-regulated	RT-qPCR	"circPDSS1 is up-regulated in urothelial bladder cancer tissues and increases with higher clinical stage. In HT-1197 and UMUC3 cells, circPDSS1 overexpression suppresses miR-16 levels and promotes proliferation, migration, and invasion, while miR-16 overexpression counteracts these effects."	0.5214
31875034	Scientific reports	2019	Circular METRN RNA hsa_circ_0037251 Promotes Glioma Progression by Sponging miR-1229-3p and Regulating mTOR Expression.	hsa_circ_0037251		hsa_circ_METRN	METRN	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR; RNA-seq	"In glioma cells, hsa_circ_0037251 (circular METRN RNA) is up-regulated and promotes proliferation, invasion and migration while suppressing apoptosis and G1 arrest. Mechanistically, it sponges miR-1229-3p, relieving repression of mTOR and forming a hsa_circ_0037251/miR-1229-3p/mTOR ceRNA axis; in vivo, this enhances xenograft growth and shortens survival."	0.7375
31877410	Molecular therapy. Nucleic acids	2020	The Circular RNome of Developmental Retina in Mice.		circTulp4	mmu_circ_Tulp4	Tulp4	retinal degeneration 	MONDO:0004580	retinal degeneration	up-regulated	RT-qPCR; RNA-seq	"In mouse retina, circTulp4 functions as a ceRNA that sponges miR-204-5p and miR-26a-5p (and binds miR-671-3p), modulating multiple target genes. In vivo knockdown of circTulp4 causes photoreceptor degeneration (thinned ONL), increased apoptosis, and impaired ERG responses, supporting an essential role in retinal function and degeneration."	0.7493
31877410	Molecular therapy. Nucleic acids	2020	The Circular RNome of Developmental Retina in Mice.		circHipk2	mmu_circ_Hipk2	Hipk2	retinal degeneration 	MONDO:0004580	retinal degeneration	up-regulated	RT-qPCR	"circHipk2 binds (sponges) miR-124-3p in retina-associated assays and is upregulated in the rd8 retinal degeneration model; its increased level is associated with increased expression of miRNA target genes, supporting a ceRNA-like role."	0.5608
31880360	Journal of clinical laboratory analysis	2020	"Circular RNA SMARCA5 correlates with favorable clinical tumor features and prognosis, and increases chemotherapy sensitivity in intrahepatic cholangiocarcinoma."			hsa_circ_SMARCA5	SMARCA5	intrahepatic cholangiocarcinoma 	MONDO:0003210	intrahepatic cholangiocarcinoma	down-regulated	RT-qPCR	"circ-SMARCA5 is down-regulated in ICC tumor tissue and higher tumor expression predicts longer overall survival and more favorable clinical features. Functionally, circ-SMARCA5 overexpression suppresses ICC cell proliferation and increases sensitivity to cisplatin and gemcitabine, although the detailed molecular mechanism was not determined in this study."	0.6524
31881015	Aging	2019	Hsa_circ_0006948 enhances cancer progression and epithelial-mesenchymal transition through the miR-490-3p/HMGA2 axis in esophageal squamous cell carcinoma.	hsa_circ_0006948	circ_0006948	hsa_circ_FNDC3B	FNDC3B	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0006948 is up-regulated in ESCC tissues/cell lines and promotes proliferation, migration, invasion, EMT, and xenograft tumor growth. Mechanistically, it acts as a miR-490-3p sponge to increase HMGA2 expression, contributing to EMT and aggressive progression, and high expression predicts poor overall survival."	0.8715
31885751	Canadian respiratory journal	2019	"Circ_MDM2_000139, Circ_ATF2_001418, Circ_CDC25C_002079, and Circ_BIRC6_001271 Are Involved in the Functions of XAV939 in Non-Small Cell Lung Cancer."		circ_MDM2_000139	hsa_circ_MDM2	MDM2	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	"circ_MDM2_000139 is a disease-associated DE-circRNA in NSCLC cells and is downregulated after XAV939 treatment. The study predicts it interacts with let-7 family miRNAs and is targeted by the transcription factor POLR2A, suggesting involvement in XAV939-related regulatory mechanisms."	0.2465
31885751	Canadian respiratory journal	2019	"Circ_MDM2_000139, Circ_ATF2_001418, Circ_CDC25C_002079, and Circ_BIRC6_001271 Are Involved in the Functions of XAV939 in Non-Small Cell Lung Cancer."		circ_ATF2_001418	hsa_circ_ATF2	ATF2	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	circ_ATF2_001418 is a disease-associated DE-circRNA in NSCLC cells and is downregulated after XAV939 treatment. It is predicted to interact with miR-16-5p/miR-134-5p and may be involved in TNF signaling-related mechanisms in this treatment context.	0.2465
31885751	Canadian respiratory journal	2019	"Circ_MDM2_000139, Circ_ATF2_001418, Circ_CDC25C_002079, and Circ_BIRC6_001271 Are Involved in the Functions of XAV939 in Non-Small Cell Lung Cancer."		circ_CDC25C_002079	hsa_circ_CDC25C	CDC25C	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	"circ_CDC25C_002079 is downregulated in NSCLC cell lines after XAV939 treatment. The study predicts interactions with miR-221-3p/miR-222-3p, suggesting a miRNA-associated regulatory role in the treatment mechanism context."	0.2465
31885751	Canadian respiratory journal	2019	"Circ_MDM2_000139, Circ_ATF2_001418, Circ_CDC25C_002079, and Circ_BIRC6_001271 Are Involved in the Functions of XAV939 in Non-Small Cell Lung Cancer."		circ_BIRC6_001271	hsa_circ_BIRC6	BIRC6	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	unknown	RNA-seq	"circ_BIRC6_001271 is identified as a disease-associated DE-circRNA in XAV939-treated NSCLC (H1299) RNA-seq data. It is predicted to interact with miR-133b, suggesting involvement in miRNA-related regulatory mechanisms in NSCLC."	0.1768
31885817	Oxidative medicine and cellular longevity	2019	Exosomal circHIPK3 Released from Hypoxia-Pretreated Cardiomyocytes Regulates Oxidative Damage in Cardiac Microvascular Endothelial Cells via the miR-29a/IGF-1 Pathway.	mmu_circ_0001052	circHIPK3	mmu_circ_HIPK3	HIPK3	oxidative stress-induced CMVECs dysfunction 	MONDO:0005267	heart disorder	dysregulated	RT-qPCR	"In hypoxia-pretreated cardiomyocyte-derived exosomes, circHIPK3 is increased and can be transferred into CMVECs. circHIPK3 protects CMVECs from H2O2-induced oxidative injury by sponging miR-29a and relieving miR-29a-mediated repression of IGF-1, reducing apoptosis and oxidative stress."	0.7449
31886256	BioMed research international	2019	Bioinformatic Analysis of Circular RNA-Associated ceRNA Network Associated with Hepatocellular Carcinoma.	hsa_circ_0009910	circ_0009910	hsa_circ_MFN2	MFN2	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	This study identified hsa_circ_0009910 as up-regulated in HCC tissues and proposed it functions as a ceRNA by sponging miR-1261 to increase the expression of UBE2L3. The hsa_circ_0009910_miR-1261_UBE2L3 axis was supported by integrated bioinformatics and RT-qPCR validation in paired clinical samples.	0.5135
31888753	Journal of experimental & clinical cancer research : CR	2019	CircNFIX promotes progression of glioma through regulating miR-378e/RPN2 axis.	hsa_circ_0049658	circNFIX	hsa_circ_NFIX	NFIX	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circNFIX (hsa_circ_0049658), derived from NFIX, is up-regulated in glioma and its high expression correlates with poor patient survival. Functionally, circNFIX promotes glioma progression (cell cycle progression, glycolysis, migration/invasion, and tumor growth) by acting as a ceRNA that sponges miR-378e to upregulate RPN2."	0.8436
31889077	Scientific reports	2019	Serum circular RNAs act as blood-based biomarkers for hypertrophic obstructive cardiomyopathy.		circDNAJC6	hsa_circ_DNAJC6	DNAJC6	hypertrophic cardiomyopathy 	MONDO:0005045	hypertrophic cardiomyopathy	down-regulated	RT-qPCR	"Serum circDNAJC6 is significantly down-regulated in HCM patients versus controls. It shows diagnostic discrimination for HCM subtypes and negatively correlates with echocardiographic severity parameters in HOCM, supporting its use as a circulating biomarker and severity indicator."	0.459
31889077	Scientific reports	2019	Serum circular RNAs act as blood-based biomarkers for hypertrophic obstructive cardiomyopathy.		circTMEM56	hsa_circ_TMEM56	TMEM56	hypertrophic cardiomyopathy 	MONDO:0005045	hypertrophic cardiomyopathy	down-regulated	RT-qPCR	"Serum circTMEM56 is significantly down-regulated in HCM patients versus controls. It demonstrates diagnostic discrimination for HCM subtypes and correlates with echocardiographic severity measures in HOCM, suggesting utility as a circulating biomarker and severity indicator."	0.459
31889077	Scientific reports	2019	Serum circular RNAs act as blood-based biomarkers for hypertrophic obstructive cardiomyopathy.		circMBOAT2	hsa_circ_MBOAT2	MBOAT2	hypertrophic cardiomyopathy 	MONDO:0005045	hypertrophic cardiomyopathy	down-regulated	RT-qPCR	"Serum circMBOAT2 is down-regulated in HCM and provides diagnostic discrimination between HCM (including HNCM/HOCM) and controls based on ROC analyses, supporting its potential as a blood-based biomarker."	0.459
31889891	Cancer cell international	2019	Circular RNA ABCB10 promotes hepatocellular carcinoma progression by increasing HMG20A expression by sponging miR-670-3p.		circABCB10	hsa_circ_ABCB10	ABCB10	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circABCB10 is up-regulated in HCC tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation and migration/invasion by sponging miR-670-3p to increase HMG20A expression, and its high expression is associated with poor overall survival."	0.7661
31889960	Cellular & molecular biology letters	2019	The novel circular RNA circ-CAMK2A enhances lung adenocarcinoma metastasis by regulating the miR-615-5p/fibronectin 1 pathway.		circ-CAMK2A	hsa_circ_CAMK2A	CAMK2A	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circ-CAMK2A is up-regulated in LUAD and promotes migration, invasion, and lung metastasis. It mainly acts as a ceRNA by sponging miR-615-5p to increase FN1 expression and consequently elevate MMP2/MMP9, and high circ-CAMK2A is associated with poor prognosis."	0.8262
31893023	Cell & bioscience	2019	Circ_0001667 promotes breast cancer cell proliferation and survival via Hippo signal pathway by regulating TAZ.	hsa_circ_0001667				breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circ_0001667 is up-regulated in breast cancer tissues and cell lines and its high expression is associated with poorer survival. Functionally, circ_0001667 promotes proliferation/survival and metastasis by sponging miR-125a-5p to increase TAZ (and related Hippo pathway components) activity."	0.7325
31894303	International journal of molecular medicine	2020	Circular RNA_101237 mediates anoxia/reoxygenation injury by targeting let_7a_5p/IGF2BP3 in cardiomyocytes.		circRNA_101237	mmu_circ_CDK8	CDK8	anoxia	MONDO:0024644	myocardial ischemia	up-regulated	RT-qPCR; Microarray	"In A/R-treated primary mouse cardiomyocytes, circRNA_101237 is up-regulated and promotes cell death by enhancing autophagy and apoptosis. Mechanistically, it sponges let-7a-5p to relieve repression of IGF2BP3, forming a circRNA_101237/let-7a-5p/IGF2BP3 axis that drives IGF2BP3-dependent autophagy."	0.762
31895689	Aging	2019	Circular RNA SMO sponges miR-338-3p to promote the growth of glioma by enhancing the expression of SMO.	hsa_circ_0001742		hsa_circ_SMO	SMO	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circSMO742 is up-regulated in glioma and mainly localizes to the cytoplasm. It promotes glioma cell proliferation, migration and invasion and inhibits apoptosis by sponging miR-338-3p, thereby increasing SMO expression; circSMO742 knockdown suppresses xenograft tumor growth."	0.8252
31896069	Molecular therapy. Nucleic acids	2020	Circular RNA circSLC26A4 Accelerates Cervical Cancer Progression via miR-1287-5p/HOXA7 Axis.	hsa_circ_0132980	circSLC26A4	hsa_circ_SLC26A4	SLC26A4	cervical cancer	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circSLC26A4 is upregulated in cervical cancer and promotes malignant phenotypes (proliferation, invasion, and xenograft tumor growth). It functions as a ceRNA by sponging miR-1287-5p to relieve repression of HOXA7, and its biogenesis is promoted by the RBP QKI via binding QREs in flanking introns."	0.8568
31900142	Journal of biomedical science	2020	"Circular RNA circ_0003204 inhibits proliferation, migration and tube formation of endothelial cell in atherosclerosis via miR-370-3p/TGFbetaR2/phosph-SMAD3 axis."	hsa_circ_0003204		hsa_circ_USP36	USP36	atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"In ox-LDL-treated human aorta endothelial cells and in plasma extracellular vesicles from cerebral atherosclerosis patients, circ_0003204 is upregulated. It mainly localizes to the cytoplasm and suppresses endothelial proliferation, migration, and tube formation by acting as a ceRNA for miR-370-3p, thereby increasing TGFbetaR2 and downstream phospho-SMAD3 signaling. Clinically, higher EV circ_0003204 shows diagnostic value and is associated with worse event-free outcome in cerebral atherosclerosis patients."	0.8766
31901148	Molecular oncology	2020	Exosome-delivered circRNA promotes glycolysis to induce chemoresistance through the miR-122-PKM2 axis in colorectal cancer.	hsa_circ_0005963	ciRS-122			colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"In colorectal cancer, exosome-delivered hsa_circ_0005963/ciRS-122 is upregulated in oxaliplatin-resistant settings and promotes glycolysis and chemoresistance. Mechanistically, ciRS-122 sponges miR-122 to increase PKM2 (mainly at the protein level), and exosomal si-ciRS-122 can reduce glycolysis and restore oxaliplatin sensitivity in vitro and in vivo."	0.7283
31905172	Aging	2020	CircNF1-419 improves the gut microbiome structure and function in AD-like mice.			rno_circ_NF1	NF1	Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	dysregulated	RT-qPCR; RNA-seq	"In AD-like mouse models, circNF1-419 is differentially expressed and, when overexpressed in brain via AAV, it improves intestinal tissue damage/homeostasis and reshapes gut microbiota composition. It is linked to enhanced autophagy and reported interactions with Dynamin-1/AP2B1 and PI3K/AKT/AMPK/mTOR-related signaling."	0.6815
31905172	Aging	2020	CircNF1-419 improves the gut microbiome structure and function in AD-like mice.	mmu_circ_0001239	circ_0001239	mmu_circ_ZCCHC11	ZCCHC11	Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	up-regulated	RNA-seq	"In AD-like mouse contexts, mmu_circ_0001239 is increased and its brain overexpression via AAV alters gut microbiota composition/diversity. Transcriptome profiling suggests it may function as a miRNA sponge affecting miRNA and downstream mRNA programs."	0.3963
31905344	Aging	2020	Circ-EPB41L5 regulates the host gene EPB41L5 via sponging miR-19a to repress glioblastoma tumorigenesis.			hsa_circ_EPB41L5	EPB41L5	glioblastoma	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR; RNA-seq	"Circ-EPB41L5 is down-regulated in glioblastoma and functions as a tumor suppressor. It mainly localizes to the cytoplasm and sponges miR-19a, thereby increasing EPB41L5 expression and suppressing downstream RhoC and AKT phosphorylation, leading to reduced proliferation, migration, invasion, and tumorigenesis. Low circ-EPB41L5 levels are associated with worse patient survival."	0.8426
31911496	mBio	2020	Kaposi's Sarcoma-Associated Herpesvirus-Encoded circRNAs Are Expressed in Infected Tumor Tissues and Are Incorporated into Virions.		circ-vIRF4			primary effusion lymphoma 	MONDO:0018842	primary effusion lymphoma	dysregulated	RT-qPCR; ISH	"This study shows KSHV circ-vIRF4 is expressed in KSHV-associated PEL cells and KS tissues/sera, displays a latent-like expression profile with little or no induction during lytic reactivation, and exists as a nuclear intron-retaining form (circ-vIRF4.IR) and a cytoplasmic exon-only form. Only the cytoplasmic exon-only form is packaged into virions, and circ-vIRF4 is more stable than the corresponding linear vIRF4 transcript."	0.6149
31911496	mBio	2020	Kaposi's Sarcoma-Associated Herpesvirus-Encoded circRNAs Are Expressed in Infected Tumor Tissues and Are Incorporated into Virions.		circPAN / circPANs			primary effusion lymphoma 	MONDO:0018842	primary effusion lymphoma	up-regulated	RT-qPCR; ISH	"circPAN is a KSHV-encoded circRNA derived from the PAN locus that is strongly induced during lytic reactivation in infected B cells and is also detected in KS tissues and patient sera/plasma. The circPAN species are found in both nucleus and cytoplasm and can be incorporated into nuclease-protected virion particles, suggesting potential roles in early infection."	0.5281
31911496	mBio	2020	Kaposi's Sarcoma-Associated Herpesvirus-Encoded circRNAs Are Expressed in Infected Tumor Tissues and Are Incorporated into Virions.		circK7.3 / circK7.3s			primary effusion lymphoma 	MONDO:0018842	primary effusion lymphoma	up-regulated	RT-qPCR; ISH	"circK7.3 is a KSHV-encoded circRNA arising from the K7.3 locus that increases upon lytic induction and is detectable in KS tissues and some sera/plasma samples. circK7.3 species are found in both nucleus and cytoplasm and can be incorporated into nuclease-protected virions, implying potential roles in early infection, though specific mechanisms were not defined."	0.5281
31911754	Cancer cell international	2020	Circ-SOX4 drives the tumorigenesis and development of lung adenocarcinoma via sponging miR-1270 and modulating PLAGL2 to activate WNT signaling pathway.			hsa_circ_SOX4	SOX4	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"Circ-SOX4 is up-regulated in LUAD tissues and cell lines and promotes proliferation, invasion, migration, and xenograft tumor growth. It mainly localizes to the cytoplasm and acts as a ceRNA by sponging miR-1270 to de-repress PLAGL2, activating Wnt/beta-catenin signaling and EMT-related changes."	0.807
31911757	Cancer cell international	2020	Up-regulation of circ_LARP4 suppresses cell proliferation and migration in ovarian cancer by regulating miR-513b-5p/LARP4 axis.			hsa_circ_LARP4	LARP4	ovarian cancer 	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR	"circ_LARP4 is down-regulated in ovarian cancer cell lines and functions as a tumor suppressor. It mainly localizes in the cytoplasm and acts as a ceRNA that sponges miR-513b-5p, thereby relieving repression of LARP4 and inhibiting proliferation/migration/invasion while promoting apoptosis."	0.8081
31917898	Thoracic cancer	2020	CircRNA CDR1as knockdown inhibits progression of non-small-cell lung cancer by regulating miR-219a-5p/SOX5 axis.			hsa_circ_CDR1	CDR1	non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circCDR1as is up-regulated in NSCLC tissues and cell lines. Its knockdown suppresses malignant phenotypes (reduced viability/colony formation, migration, invasion; increased apoptosis) by acting as a ceRNA that sponges miR-219a-5p and thereby increases SOX5 expression."	0.6966
31922210	Molecular medicine reports	2020	Circular RNA cSMARCA5 regulates the progression of cervical cancer by acting as a microRNA_432 sponge.	hsa_circ_0001445	cSMARCA5	hsa_circ_SMARCA5	SMARCA5	cervical cancer	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"cSMARCA5 is up-regulated in cervical cancer tissues and cell lines and promotes proliferation and invasion. Mechanistically, it functions as a sponge for miR-432, thereby relieving miR-432-mediated repression of EGFR and enhancing ERK1/2 signaling."	0.7129
31923350	Journal of cellular and molecular medicine	2020	Extracellular nanovesicles-transmitted circular RNA has_circ_0000190 suppresses osteosarcoma progression.	hsa_circ_0000190				osteosarcoma	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR	"hsa_circ_0000190 (circ-0000190) is down-regulated in osteosarcoma tissues and plasma EVs and functions as a tumour suppressor. It is transferred via EVs from normal osteoblasts to osteosarcoma cells, where it mainly localizes to the cytoplasm and sponges miR-767-5p to modulate TET1, inhibiting proliferation, migration, invasion and tumour growth, with diagnostic potential (AUC 0.889)."	0.8595
31928527	Journal of experimental & clinical cancer research : CR	2020	Circular RNA circRHOBTB3 acts as a sponge for miR-654-3p inhibiting gastric cancer growth.			hsa_circ_RHOBTB3	RHOBTB3	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; RNA-seq	"circRHOBTB3 is down-regulated in gastric cancer and functions as a tumor suppressor. It sponges miR-654-3p to restore p21 protein expression, thereby inhibiting proliferation and inducing G1 arrest, and suppressing xenograft tumor growth."	0.8837
31931709	BMC genomics	2020	Transcriptome-wide map of m6A circRNAs identified in a rat model of hypoxia mediated pulmonary hypertension.			rno_circ_Xpo6	Xpo6	Hypoxia mediated pulmonary hypertension 	MONDO:0005149	pulmonary hypertension	down-regulated	RT-qPCR; RNA-seq	"In a rat hypoxia-mediated pulmonary hypertension model, circXpo6 (from host gene Xpo6) is an m6A-modified circRNA whose m6A-associated signal/abundance is decreased under hypoxia and is identified as HPH-associated. The study further places circXpo6 within a predicted circRNA_miRNA_mRNA co-expression (ceRNA) network potentially linked to PH-related pathways (e.g., Wnt and FoxO), but its direct functional role was not experimentally elaborated."	0.7724
31931709	BMC genomics	2020	Transcriptome-wide map of m6A circRNAs identified in a rat model of hypoxia mediated pulmonary hypertension.			rno_circ_Tmtc3	Tmtc3	Hypoxia mediated pulmonary hypertension 	MONDO:0005149	pulmonary hypertension	down-regulated	RT-qPCR; RNA-seq	"In a rat hypoxia-mediated pulmonary hypertension model, circTmtc3 (from host gene Tmtc3) is identified as an m6A-modified circRNA that decreases under hypoxia/HPH conditions (validated by divergent-primer PCR and MeRIP-qRT-PCR). The study links circTmtc3 to a predicted circRNA_miRNA_mRNA co-expression network relevant to PH-associated pathways, but does not experimentally define its downstream functional effects."	0.7724
31931771	BMC pulmonary medicine	2020	Knockdown of circ-ABCB10 promotes sensitivity of lung cancer cells to cisplatin via miR-556-3p/AK4 axis.			hsa_circ_ABCB10	ABCB10	lung cancer 	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circ-ABCB10 is upregulated in NSCLC cell lines and mainly localizes to the cytoplasm. It sponges miR-556-3p to relieve repression of AK4, thereby promoting malignant phenotypes and reducing cisplatin sensitivity; circ-ABCB10 knockdown enhances cisplatin response in vitro."	0.7918
31933490	Medical science monitor : international medical journal of experimental and clinical research	2020	Hsa_circ_0086414 Might Be a Diagnostic Biomarker of Oral Squamous Cell Carcinoma.	hsa_circ_0086414				oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0086414 is significantly down-regulated in OSCC tissues and cell lines and lower expression associates with higher TNM stage, larger tumor size, and lymph node metastasis. It shows diagnostic potential (AUC 0.749). Mechanistically, the study builds a predicted hsa_circ_0086414_miRNA_mRNA network and suggests links to AMPK and cAMP signaling, but the regulatory mechanism is not experimentally established."	0.6608
31935372	Cancer cell	2020	Epigenetic Silencing of CDR1as Drives IGF2BP3-Mediated Melanoma Invasion and Metastasis.	hsa_circ_0001946	CDR1as / ciRS7	hsa_circ_CDR1	CDR1	melanoma 	MONDO:0005105	melanoma	down-regulated	RT-qPCR; ISH; RNA-seq	"In melanoma, CDR1as is epigenetically silenced during progression and functions as a metastasis suppressor. Loss of CDR1as promotes invasion and lung metastasis via a miR-7-independent mechanism that requires interaction with the RBP IGF2BP3 and regulation of pro-invasive IGF2BP3 targets."	0.8222
31938060	Theranostics	2020	Smooth muscle SIRT1 reprograms endothelial cells to suppress angiogenesis after ischemia.		cZFP609	mmu_circ_Zfp609	ZFP609	lower extremity peripheral artery disease 	MONDO:0005386	peripheral arterial disease	up-regulated	RT-qPCR	"cZFP609/cZNF609 is increased (notably in VSMC-derived exosomes and in patient plasma) in ischemia/PAD settings and suppresses angiogenesis. It binds HIF1alpha in EC cytoplasm to block nuclear translocation and downstream VEGFA induction, thereby inhibiting EC proliferation, migration, and tube formation; its knockdown improves perfusion recovery in hindlimb ischemia models."	0.6744
31938060	Theranostics	2020	Smooth muscle SIRT1 reprograms endothelial cells to suppress angiogenesis after ischemia.		cZNF609	hsa_circ_ZNF609	ZNF609	lower extremity peripheral artery disease 	MONDO:0005386	peripheral arterial disease	up-regulated	RT-qPCR	"cZFP609/cZNF609 is increased (notably in VSMC-derived exosomes and in patient plasma) in ischemia/PAD settings and suppresses angiogenesis. It binds HIF1alpha in EC cytoplasm to block nuclear translocation and downstream VEGFA induction, thereby inhibiting EC proliferation, migration, and tube formation; its knockdown improves perfusion recovery in hindlimb ischemia models."	0.6744
31942183	Journal of Cancer	2020	CircRNA_100395 inhibits cell proliferation and metastasis in ovarian cancer via regulating miR-1228/p53/epithelial-mesenchymal transition (EMT) axis.	hsa_circ_0015278	circ_100395	hsa_circ_KLHL20	KLHL20	ovarian cancer	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR	"circ_100395 is down-regulated in ovarian cancer tissues and cell lines, and lower expression is associated with worse clinical outcomes. Functionally, circ_100395 suppresses ovarian cancer cell proliferation, migration/invasion and EMT by acting as a miR-1228 sponge and relieving miR-1228-mediated repression of p53."	0.7078
31944395	Journal of clinical laboratory analysis	2020	Circular RNA SMARCA5 may serve as a tumor suppressor in non-small cell lung cancer.		Circ_SMARCA5 	hsa_circ_SMARCA5	SMARCA5	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"circ-SMARCA5 is down-regulated in NSCLC tumor tissues and cell lines. Its higher expression is associated with smaller tumor size, less lymph node metastasis, lower TNM stage, and independently predicts longer DFS and OS. circ-SMARCA5 overexpression suppresses NSCLC cell proliferation and increases sensitivity to cisplatin and gemcitabine."	0.6524
31944556	Molecular oncology	2020	Exosome-transmitted circ_MMP2 promotes hepatocellular carcinoma metastasis by upregulating MMP2.	hsa_circ_0039411	circ_MMP2	hsa_circ_MMP2	MMP2	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"In hepatocellular carcinoma, exosome-transmitted circ_MMP2 is upregulated in metastatic tissues and promotes migration/invasion, EMT and metastasis. Mechanistically it acts as a ceRNA that sponges miR-136-5p to upregulate MMP2, and high circ_MMP2 is associated with worse overall survival."	0.8931
31945729	Molecular therapy. Nucleic acids	2020	circCELSR1 (hsa_circ_0063809) Contributes to Paclitaxel Resistance of Ovarian Cancer Cells by Regulating FOXR2 Expression via miR-1252.	hsa_circ_0063809	circCELSR1	hsa_circ_CELSR1	CELSR1	ovarian cancer	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; Microarray	"circCELSR1 (hsa_circ_0063809), derived from CELSR1, is up-regulated in paclitaxel-resistant ovarian cancer tissues and PTX-resistant cell lines. It promotes PTX resistance and tumor growth by acting as a ceRNA that sponges miR-1252, thereby increasing FOXR2 expression; circCELSR1 knockdown induces G0/G1 arrest, increases apoptosis, and enhances PTX sensitivity in vitro and in a xenograft model."	0.853
31948430	BMC cancer	2020	Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma.	hsa_circ_0005273	hsa_circRNA_104700 / circ-PTK2	hsa_circ_PTK2	PTK2	multiple myeloma 	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR; Microarray	"circ-PTK2 is up-regulated in multiple myeloma bone marrow plasma cells and has diagnostic value. Higher circ-PTK2 is associated with worse treatment response and poorer survival, and it is proposed to promote MM progression via miRNA sponging and/or enhancing PTK2 expression."	0.636
31948430	BMC cancer	2020	Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma.	hsa_circ_0077765	hsa_circRNA_104181 / circ-RNF217	hsa_circ_RNF217	RNF217	multiple myeloma 	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR; Microarray	"circ-RNF217 is up-regulated in multiple myeloma and shows diagnostic potential. Higher circ-RNF217 is linked to worse treatment response and poorer survival, supporting its value as a prognostic biomarker."	0.636
31948430	BMC cancer	2020	Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma.	hsa_circ_0009581	hsa_circRNA_100033 / circ-RERE	hsa_circ_RERE	RERE	multiple myeloma 	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR; Microarray	"circ-RERE is up-regulated in multiple myeloma and can help distinguish MM patients from healthy controls, indicating potential diagnostic value. No specific mechanism or pathway was experimentally established in this study."	0.636
31948430	BMC cancer	2020	Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma.	hsa_circ_0007146	hsa_circRNA_101695 / circ-NAGPA	hsa_circ_NAGPA	NAGPA	multiple myeloma 	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR; Microarray	circ-NAGPA is up-regulated in multiple myeloma bone marrow plasma cells and can help predict MM risk (ROC analysis). The study did not experimentally define its molecular mechanism.	0.636
31948430	BMC cancer	2020	Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma.	hsa_circ_0004136	hsa_circRNA_104134 / circ-KCNQ5	hsa_circ_KCNQ5	KCNQ5	multiple myeloma 	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR; Microarray	circ-KCNQ5 is up-regulated in multiple myeloma and shows diagnostic potential by ROC analysis for distinguishing MM from controls. The study did not establish a specific downstream mechanism for circ-KCNQ5.	0.636
31948430	BMC cancer	2020	Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma.	hsa_circ_0001947	hsa_circRNA_105034 / circ-AFF2	hsa_circ_AFF2	AFF2	multiple myeloma 	MONDO:0009693	plasma cell myeloma	down-regulated	RT-qPCR; Microarray	"circ-AFF2 is down-regulated in multiple myeloma and has diagnostic value, while higher circ-AFF2 levels indicate better treatment response and improved survival. It is proposed to act as a ceRNA by sponging miR-638 and potentially reducing drug resistance."	0.636
31948430	BMC cancer	2020	Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma.	hsa_circ_0001910	hsa_circRNA_104980 / circ-WWC3	hsa_circ_WWC3	WWC3	multiple myeloma 	MONDO:0009693	plasma cell myeloma	down-regulated	RT-qPCR; Microarray	circ-WWC3 is down-regulated in multiple myeloma and shows diagnostic potential (predicts lower MM risk and is cited as a potential diagnostic biomarker). The study did not define a specific mechanism for circ-WWC3.	0.636
31948430	BMC cancer	2020	Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma.	hsa_circ_0007609	hsa_circRNA_103106 / circ-DNAJC5	hsa_circ_DNAJC5	DNAJC5	multiple myeloma 	MONDO:0009693	plasma cell myeloma	down-regulated	RT-qPCR; Microarray	"circ-DNAJC5 is down-regulated in multiple myeloma and may help distinguish MM from controls (ROC). In survival analysis, circ-DNAJC5 is associated with shorter PFS, while no significant association with OS was reported."	0.636
31948430	BMC cancer	2020	Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma.	hsa_circ_0071375	hsa_circRNA_103765 / circ-KLHL2	hsa_circ_KLHL2	KLHL2	multiple myeloma 	MONDO:0009693	plasma cell myeloma	down-regulated	RT-qPCR; Microarray	circ-KLHL2 is down-regulated in multiple myeloma and has diagnostic value in distinguishing MM from controls (ROC). No significant association with survival or a specific molecular mechanism was reported.	0.636
31948430	BMC cancer	2020	Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma.	hsa_circ_0000651	hsa_circRNA_101648 / circ-IQGAP1	hsa_circ_IQGAP1	IQGAP1	multiple myeloma 	MONDO:0009693	plasma cell myeloma	down-regulated	RT-qPCR; Microarray	circ-IQGAP1 is down-regulated in multiple myeloma and shows diagnostic potential (ROC predicts lower MM risk). No significant survival association or mechanism was established in this study.	0.636
31948430	BMC cancer	2020	Comprehensive profiling of circular RNA expressions reveals potential diagnostic and prognostic biomarkers in multiple myeloma.	hsa_circ_0020594	hsa_circRNA_100731 / circ-AL137655	hsa_circ_AL137655	AL137655	multiple myeloma 	MONDO:0009693	plasma cell myeloma	down-regulated	RT-qPCR; Microarray	circ-AL137655 is down-regulated in multiple myeloma and has diagnostic value (ROC predicts lower MM risk). No significant association with survival or a specific mechanism was established in this study.	0.636
31949130	Cell death & disease	2020	circRNA-002178 act as a ceRNA to promote PDL1/PD1 expression in lung adenocarcinoma.		circRNA-002178	hsa_circ_RPPH1	RPPH1	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circRNA-002178 is up-regulated in LUAD tissues/cell lines and is enriched in serum exosomes. It functions as a ceRNA: sponging miR-34a to increase PDL1 in tumor cells and, after exosomal transfer into CD8+ T cells, sponging miR-28-5p to increase PD1, promoting T-cell exhaustion and immune escape; it also shows strong diagnostic potential via exosomal detection."	0.8684
31950059	BioMed research international	2019	hsa_circ0021347 as a Potential Target Regulated by B7-H3 in Modulating the Malignant Characteristics of Osteosarcoma.	hsa_circ_0021347				osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; Microarray	"hsa_circ0021347 is significantly down-regulated in osteosarcoma tissues and cell lines and is inversely correlated with B7-H3 expression. Lower hsa_circ0021347 expression associates with more advanced TNM stage, while higher expression associates with better patient survival. The study predicts a circRNA_miRNA network (including miR-646) and proposes a potential hsa_circ0021347/miR-646/NOB1 axis and MAPK-related involvement, but the mechanism is not experimentally validated."	0.5047
31951319	Journal of cellular and molecular medicine	2020	circRNA circ-CCND1 promotes the proliferation of laryngeal squamous cell carcinoma through elevating CCND1 expression via interacting with HuR and miR-646.	hsa_circ_0023303	circ_CCND1	hsa_circ_CCND1	CCND1	laryngeal squamous cell carcinoma 	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR	circ-CCND1 is up-regulated in LSCC and promotes proliferation and xenograft tumor growth. It elevates CCND1 expression post-transcriptionally by binding HuR to enhance CCND1 mRNA stability and by sponging miR-646 to relieve repression on CCND1 3¡ä-UTR; high circ-CCND1 correlates with aggressive features and poorer overall survival.	0.8215
31951855	Molecular therapy. Nucleic acids	2020	Circular RNA circFOXM1 Plays a Role in Papillary Thyroid Carcinoma by Sponging miR-1179 and Regulating HMGB1 Expression.	hsa_circ_0025033		hsa_circ_FOXM1	FOXM1	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"circFOXM1 (hsa_circ_0025033), derived from FOXM1, is up-regulated in papillary thyroid carcinoma tissues and cell lines and is mainly localized in the cytoplasm. It promotes PTC proliferation and in vivo tumor growth by acting as a ceRNA sponge for miR-1179, thereby increasing HMGB1 expression."	0.8397
31956297	Cancer cell international	2020	"CircZDHHC20 represses the proliferation, migration and invasion in trophoblast cells by miR-144/GRHL2 axis."	hsa_circ_0006732		hsa_circ_ZDHHC20	ZDHHC20	preeclampsia 	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR	"In preeclampsia placenta, circZDHHC20 is up-regulated and predominantly cytoplasmic. It suppresses trophoblast proliferation, migration, and invasion by sponging miR-144 and thereby relieving miR-144-mediated repression of GRHL2 (circZDHHC20/miR-144/GRHL2 ceRNA axis)."	0.7785
31956297	Cancer cell international	2020	"CircZDHHC20 represses the proliferation, migration and invasion in trophoblast cells by miR-144/GRHL2 axis."	hsa_circ_0029698		hsa_circ_ZDHHC20	ZDHHC20	preeclampsia 	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR	"In preeclampsia placenta, circZDHHC20 is up-regulated and predominantly cytoplasmic. It suppresses trophoblast proliferation, migration, and invasion by sponging miR-144 and thereby relieving miR-144-mediated repression of GRHL2 (circZDHHC20/miR-144/GRHL2 ceRNA axis)."	0.7785
31957232	Journal of cellular and molecular medicine	2020	Circular RNA hsa_circRNA_002178 silencing retards breast cancer progression via microRNA-328-3p-mediated inhibition of COL1A1.	hsa_circ_0000519	hsa_circRNA_002178			breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"In breast cancer, hsa_circRNA_002178 is up-regulated and mainly localized in the cytoplasm. It promotes malignant phenotypes (proliferation, energy metabolism and angiogenesis) and tumor growth/inflammation by sponging miR-328-3p, thereby relieving miR-328-3p-mediated repression of COL1A1."	0.8066
31960764	Technology in cancer research & treatment	2020	Circular RNA cir-ITCH Promotes Osteosarcoma Migration and Invasion through cir-ITCH/miR-7/EGFR Pathway.		cir-ITCH	hsa_circ_ITCH	ITCH	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"In osteosarcoma cell lines, cir-ITCH is up-regulated and promotes proliferation, migration, and invasion. Mechanistically, cir-ITCH suppresses miR-7, resulting in increased EGFR expression and phosphorylation and activation of EGFR/ERK signaling, which drives metastatic phenotypes."	0.6253
31961997	Cell proliferation	2020	Circular RNA hsa_circ_0061825 (circ-TFF1) contributes to breast cancer progression through targeting miR-326/TFF1 signalling.	hsa_circ_0061825	circ_TFF1	hsa_circ_TFF1	TFF1	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"This study reports that circ-TFF1 (hsa_circ_0061825) is up-regulated in breast cancer and mainly localized in the cytoplasm. circ-TFF1 promotes breast cancer proliferation, migration, invasion, EMT and in vivo tumor growth/metastasis by acting as a ceRNA that sponges miR-326 to increase TFF1 expression."	0.852
31962380	Thoracic cancer	2020	Circular RNA 0007255 regulates the progression of breast cancer through miR-335-5p/SIX2 axis.	hsa_circ_0007255		hsa_circ_KIF4A	KIF4A	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0007255 is up-regulated in breast cancer serum/tissues/cell lines and mainly localizes to the cytoplasm. It promotes malignant behaviors and xenograft tumor growth by sponging miR-335-5p, thereby increasing SIX2 expression, suggesting diagnostic potential (ROC AUC reported)."	0.8025
31969212	Oncology research	2020	MafF Is Regulated via the circ-ITCH/miR-224-5p Axis and Acts as a Tumor Suppressor in Hepatocellular Carcinoma.		circ-ITCH	hsa_circ_ITCH	ITCH	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"circ-ITCH is down-regulated in HCC tissues and cell lines. It directly sponges miR-224-5p, thereby increasing MafF expression and contributing to anti-proliferative and pro-apoptotic effects in HCC cells via the circ-ITCH/miR-224-5p/MafF axis."	0.6996
31969560	Cell death & disease	2020	Circular RNA FAM114A2 suppresses progression of bladder cancer via regulating _NP63 by sponging miR-762.	hsa_circ_0001546	circFAM114A2	hsa_circ_FAM114A2	FAM114A2	urothelial carcinoma of bladder 	MONDO:0005611	bladder transitional cell carcinoma	down-regulated	RT-qPCR; RNA-seq	"circFAM114A2 is down-regulated in urothelial carcinoma of bladder and acts as a tumor suppressor. It sponges miR-762 in the cytoplasm to relieve repression of TP63/_NP63, thereby inhibiting bladder cancer cell proliferation, migration, and invasion and suppressing xenograft tumor growth."	0.8635
31970831	Journal of clinical laboratory analysis	2020	"Circular RNA VRK1 correlates with favourable prognosis, inhibits cell proliferation but promotes apoptosis in breast cancer."	hsa_circ_0141206		hsa_circ_VRK1	VRK1	breast cancer	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	"circ_VRK1 is down-regulated in breast cancer tumor tissues and lower in several breast cancer cell lines. Functionally, circ_VRK1 suppresses proliferation and promotes apoptosis in MDA_MB_231 cells, and higher circ_VRK1 expression is associated with earlier stage disease and better overall survival."	0.7211
31973707	Molecular cancer	2020	CircPTK2 (hsa_circ_0005273) as a novel therapeutic target for metastatic colorectal cancer.	hsa_circ_0005273	circPTK2	hsa_circ_PTK2	PTK2	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; Microarray	"circPTK2 (hsa_circ_0005273), derived from PTK2, is up-regulated in CRC tissues and serum and is associated with metastasis and poorer overall survival. Functionally, circPTK2 promotes aggressive phenotypes and EMT in vitro and in vivo, at least in part by physically binding vimentin (Ser38/Ser55/Ser82) and increasing vimentin and related EMT/metastasis markers."	0.7876
31973767	Journal of experimental & clinical cancer research : CR	2020	Exosomal circRNA-100338 promotes hepatocellular carcinoma metastasis via enhancing invasiveness and angiogenesis.		circRNA-100338			hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"Exosomal circRNA-100,338 is up-regulated in highly metastatic HCC cells and their exosomes and promotes HCC invasion and metastasis. After transfer to recipient HUVECs, it enhances endothelial proliferation, angiogenesis, permeability and VM formation, partly associated with altered VE-Cadherin/ZO-1 and increased MMP9, and it binds multiple proteins (including NOVA2). Serum exosomal circRNA-100,338 dynamics after hepatectomy are associated with pulmonary metastasis risk and poorer survival."	0.7132
31978088	PloS one	2020	Redefining transcriptional regulation of the APOE gene and its association with Alzheimer's disease.			hsa_circ_APOE	APOE	Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR	APOE circRNA is abundant in human postmortem brain and is up-regulated in AD frontal lobe versus controls. It localizes mainly to the cytoplasm and is linked to an epigenetically influenced APOE transcriptional program involving CpG island methylation and MECP2 binding; its precise function remains unknown but it is proposed as a potential AD biomarker.	0.585
31978088	PloS one	2020	Redefining transcriptional regulation of the APOE gene and its association with Alzheimer's disease.		L-circRNA	hsa_circ_APOE	APOE	Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR	L-circRNA is one of two APOE circRNA isoforms identified from APOE exons 3_4 via back-splicing. The study did not report L-circRNA-specific disease association or function separate from overall APOE circRNAs.	0.1848
31978088	PloS one	2020	Redefining transcriptional regulation of the APOE gene and its association with Alzheimer's disease.		S-circRNA	hsa_circ_APOE	APOE	Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR	S-circRNA is the predominant APOE circRNA isoform (~30-fold more abundant than L-circRNA) identified via back-splicing between APOE exons 4 and 3. The paper did not provide S-circRNA-specific AD association or functional mechanism separate from overall APOE circRNAs.	0.1848
31985027	International journal of molecular medicine	2020	CircCTDP1 promotes nasopharyngeal carcinoma progression via a microRNA_320b/HOXA10/TGFbeta2 pathway.			hsa_circ_CTDP1	CTDP1	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"circCTDP1 is upregulated in nasopharyngeal carcinoma and promotes malignant phenotypes (proliferation/migration/invasion) while inhibiting apoptosis. Mechanistically, it sponges miR-320b to upregulate HOXA10, which increases TGFbeta2 expression, contributing to NPC progression and poorer patient survival."	0.6542
31988434	Molecular psychiatry	2020	A psychiatric disease-related circular RNA controls synaptic gene expression and cognition.		circHomer1a	hsa_circ_HOMER1	HOMER1	schizophrenia 	MONDO:0005090	schizophrenia	down-regulated	RT-qPCR; Microarray	"circHomer1a (from HOMER1) is down-regulated in schizophrenia and bipolar disorder brain and patient-derived neurons. In vivo knockdown in mouse OFC impairs cognitive flexibility and shifts alternative mRNA isoform expression of synaptic/psychiatric disease-related genes. Mechanistically, circHomer1a binds the RBP HuD, which influences its synaptic abundance."	0.8242
31988434	Molecular psychiatry	2020	A psychiatric disease-related circular RNA controls synaptic gene expression and cognition.		circADAM22	hsa_circ_ADAM22	ADAM22	bipolar disorder 	MONDO:0004985	bipolar disorder	down-regulated	RT-qPCR; Microarray	"circADAM22 (from ADAM22) is significantly down-regulated in the orbitofrontal cortex of bipolar disorder patients in this study, based on microarray screening followed by qRT-PCR validation."	0.5909
31988434	Molecular psychiatry	2020	A psychiatric disease-related circular RNA controls synaptic gene expression and cognition.		circCUL4A	hsa_circ_CUL4A	CUL4A	schizophrenia 	MONDO:0005090	schizophrenia	up-regulated	RT-qPCR; Microarray	"circCUL4A (from CUL4A) is up-regulated in the orbitofrontal cortex of schizophrenia patients in this study, based on microarray screening followed by qRT-PCR validation."	0.5909
31991759	Biomolecules	2020	Circular RNA Expression Profiles in Plasma from Patients with Heart Failure Related to Platelet Activity.	hsa_circ_0112085		hsa_circ_MARC2	MARC2	heart failure 	MONDO:0005252	heart failure	up-regulated	RT-qPCR; Microarray	hsa_circ_0112085 is increased in plasma from heart failure patients versus controls and shows diagnostic potential for HF based on ROC analysis.	0.5047
31991759	Biomolecules	2020	Circular RNA Expression Profiles in Plasma from Patients with Heart Failure Related to Platelet Activity.	hsa_circ_0062960		hsa_circ_DEPDC5	DEPDC5	heart failure 	MONDO:0005252	heart failure	up-regulated	RT-qPCR; Microarray	"hsa_circ_0062960 is up-regulated in plasma of heart failure patients and shows the best diagnostic performance among tested circRNAs (AUC 0.838). Its expression correlates positively with serum BNP levels, and host-gene enrichment links dysregulated circRNAs to platelet activation."	0.5047
31991759	Biomolecules	2020	Circular RNA Expression Profiles in Plasma from Patients with Heart Failure Related to Platelet Activity.	hsa_circ_0053919		hsa_circ_LTBP1	LTBP1	heart failure 	MONDO:0005252	heart failure	up-regulated	RT-qPCR; Microarray	hsa_circ_0053919 is up-regulated in plasma of heart failure patients and has diagnostic value for HF based on ROC analysis (AUC 0.759).	0.4679
31991759	Biomolecules	2020	Circular RNA Expression Profiles in Plasma from Patients with Heart Failure Related to Platelet Activity.	hsa_circ_0014010		hsa_circ_PRPF3	PRPF3	heart failure 	MONDO:0005252	heart failure	up-regulated	RT-qPCR; Microarray	"hsa_circ_0014010 is up-regulated in plasma of heart failure patients versus controls and was RT-qPCR-validated as differentially expressed, but no further diagnostic performance or mechanism was reported."	0.3588
31992303	Molecular cancer	2020	Circular RNA MAPK4 (circ-MAPK4) inhibits cell apoptosis via MAPK signaling pathway by sponging miR-125a-3p in gliomas.	hsa_circ_0047688		hsa_circ_MAPK4	MAPK4	gliomas 	MONDO:0021042	glioma	up-regulated	RT-qPCR; Microarray	"circ-MAPK4 is up-regulated in glioma tissues/cell lines and correlates with advanced tumor stage. Functionally, it promotes glioma cell survival, invasion, and tumorigenesis by inhibiting apoptosis, mainly via sponging miR-125a-3p and suppressing p38/MAPK phosphorylation."	0.8109
31994979	Technology in cancer research & treatment	2020	HGF/c-Met Promote Renal Carcinoma Cancer Stem Cells Enrichment Through Upregulation of Cir-CCDC66.	hsa_circ_0001313		hsa_circ_CCDC66	CCDC66	renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR	"cir-CCDC66 is up-regulated in RCC cell lines and further enriched in CSC spheres. Functionally, cir-CCDC66 promotes RCC cell growth and CSC sphere formation/frequency. Mechanistically, HGF/c-Met activation increases cir-CCDC66, and cir-CCDC66 is required for c-Met-driven CSC enrichment."	0.528
31997941	Cancer cell international	2020	Circular RNA ATXN7 promotes the development of gastric cancer through sponging miR-4319 and regulating ENTPD4.			hsa_circ_ATXN7	ATXN7	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circATXN7 is up-regulated in gastric cancer tissues and cell lines and shows oncogenic effects by promoting proliferation/invasion and inhibiting apoptosis. Mechanistically, it acts as a ceRNA sponge for miR-4319 to derepress ENTPD4 (circATXN7/miR-4319/ENTPD4 axis), and its knockdown suppresses xenograft tumor growth and metastasis signals."	0.8871
31999672	Medical science monitor : international medical journal of experimental and clinical research	2020	Protective Effect of Circular RNA (CircRNA) Ddx17 in Ovalbumin (OVA)-Induced Allergic Rhinitis (AR) Mice.		circDdx17	mmu_circ_Ddx17	Ddx17	allergic rhinitis 	MONDO:0011786	allergic rhinitis	down-regulated	RT-qPCR	"In OVA-induced allergic rhinitis mice, circDdx17 is down-regulated. circDdx17 overexpression alleviates AR symptoms and nasal mucosa pathology and reduces IgE and inflammatory cytokines, at least partly by interacting with and suppressing miR-17-5p."	0.6376
32002039	Oncology letters	2020	Analysis of circular RNA-associated competing endogenous RNA network in breast cancer.	hsa_circ_0000520		hsa_circ_RPPH1	RPPH1	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	hsa_circ_0000520 is up-regulated in breast cancer tissues and cell lines. The study builds a predicted circRNA_miRNA_mRNA ceRNA network and enrichment analyses suggesting roles related to transcriptional regulation and pathways including endocytosis and cell cycle.	0.5541
32002039	Oncology letters	2020	Analysis of circular RNA-associated competing endogenous RNA network in breast cancer.	hsa_circ_0006220		hsa_circ_TADA2A	TADA2A	breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	hsa_circ_0006220 is down-regulated in breast cancer tissues and cell lines. The study predicts it may participate in a circRNA_miRNA_mRNA ceRNA network and notes PI3K-AKT signaling is enriched among predicted target genes.	0.5541
32002039	Oncology letters	2020	Analysis of circular RNA-associated competing endogenous RNA network in breast cancer.	hsa_circ_0000977		hsa_circ_NOL10	NOL10	breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0000977 is down-regulated in breast cancer tissues and cell lines. The paper predicts it participates in a ceRNA network, and enrichment analysis highlights MAPK signaling among pathways associated with its predicted targets."	0.5541
32002039	Oncology letters	2020	Analysis of circular RNA-associated competing endogenous RNA network in breast cancer.	hsa_circ_0043278		hsa_circ_TADA2A	TADA2A	breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0043278 (circTADA2A) is down-regulated in breast cancer tissues and cell lines. The paper predicts it functions within a circRNA_miRNA_mRNA ceRNA network, with enrichment implicating PI3K-AKT signaling and stem-cell pluripotency regulation among associated pathways; an ORF is predicted suggesting possible translation."	0.5541
32003753	Aging	2020	Hsa_circ_0070963 inhibits liver fibrosis via regulation of miR-223-3p and LEMD3.	hsa_circ_0070963		hsa_circ_SCLT1	SCLT1	liver fibrosis	MONDO:0100430	fibrotic liver disease	down-regulated	RT-qPCR; Northern Blot	"hsa_circ_0070963 is down-regulated during liver fibrosis and HSC activation. Its restoration suppresses HSC proliferation and induces G1/S arrest, reducing fibrosis markers (alpha-SMA, Col1A1). Mechanistically, it sponges miR-223-3p to de-repress LEMD3, thereby attenuating CCl4-induced liver fibrosis in vivo."	0.78
32005118	Molecular cancer	2020	Hsa_circ_001680 affects the proliferation and migration of CRC and mediates its chemoresistance by regulating BMI1 through miR-340.	hsa_circ_0000598	circ_001680	hsa_circ_B2M	B2M	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"In colorectal cancer, circ_001680 is up-regulated and promotes proliferation, migration, tumorigenicity, and CSC-like properties. Mechanistically, it sponges miR-340 to relieve repression of BMI1, thereby enhancing stemness and inducing irinotecan resistance."	0.815
32009804	OncoTargets and therapy	2019	Utility Of Plasma circBNC2 As A Diagnostic Biomarker In Epithelial Ovarian Cancer.	hsa_circ_0008732		hsa_circ_BNC2	BNC2	epithelial ovarian cancer 	MONDO:0005140	ovarian carcinoma	down-regulated	RT-qPCR	"Plasma circBNC2 (hsa_circ_0008732, from host gene BNC2) is down-regulated in epithelial ovarian cancer and shows high diagnostic performance (ROC AUC ~0.88_0.92) versus benign ovarian cysts and healthy controls, including early-stage EOC. Lower circBNC2 levels are associated with more aggressive clinicopathologic features such as higher grade, lymph node metastasis, and distant metastasis."	0.4187
32010263	Experimental and therapeutic medicine	2020	Differential expression profile study and gene function analysis of maternal foetal-derived circRNA for screening for Down's syndrome.		hsa_circRNA_103127	hsa_circ_DYRK1A	DYRK1A	Down's syndrome 	MONDO:0008608	Down syndrome	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_103127 was identified as an upregulated circRNA in Down's syndrome based on cord blood circRNA microarray and was validated by RT-qPCR in peripheral blood from children. It is linked to the host gene DYRK1A, and its role is discussed within a broader predicted circRNA/miRNA/mRNA interaction framework without specific miRNA partners reported for this circRNA."	0.4032
32010263	Experimental and therapeutic medicine	2020	Differential expression profile study and gene function analysis of maternal foetal-derived circRNA for screening for Down's syndrome.		hsa_circRNA_103112	hsa_circ_USP25	USP25	Down's syndrome 	MONDO:0008608	Down syndrome	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_103112 is upregulated in DS in both umbilical cord blood and peripheral blood. It is predicted to act as a miRNA sponge (hsa-miR-20b-3p/93-3p/370-3p/520d-3p/651-3p) within a circRNA-miRNA-mRNA interaction network and is linked to the host gene USP25, suggesting involvement in DS pathogenesis and potential use as a non-invasive prenatal blood biomarker."	0.4032
32010263	Experimental and therapeutic medicine	2020	Differential expression profile study and gene function analysis of maternal foetal-derived circRNA for screening for Down's syndrome.		hsa_circRNA_104907	hsa_circ_STRBP	STRBP	Down's syndrome 	MONDO:0008608	Down syndrome	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_104907 is downregulated in DS based on cord blood circRNA microarray and was validated by RT-qPCR in peripheral blood from children. It is associated with the host gene STRBP, but the study does not report specific miRNA partners or a detailed mechanism for this circRNA."	0.3588
32015691	Cancer cell international	2020	Identification of a potentially functional circRNA-miRNA-mRNA regulatory network for investigating pathogenesis and providing possible biomarkers of bladder cancer.	hsa_circ_0011385		hsa_circ_EIF3I	EIF3I	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"This study identified hsa_circ_0011385 as an up-regulated circRNA in bladder cancer tissues and built a circRNA_miRNA_mRNA subnetwork centered on it. The authors propose that hsa_circ_0011385 may act as a miRNA sponge (ceRNA mechanism) affecting carcinogenesis-related pathways, and it may serve as a potential biomarker for BCa."	0.4032
32019579	Molecular cancer	2020	circRIP2 accelerates bladder cancer progression via miR-1305/Tgf-beta2/smad3 pathway.	hsa_circ_0005777		hsa_circ_RIP2	RIP2	bladder cancer	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"circRIP2 is down-regulated in bladder cancer tissues and higher levels correlate with less aggressive clinicopathologic features and better survival. Functionally, circRIP2 promotes proliferation, migration/invasion and tumor growth, and induces EMT by sponging miR-1305 to upregulate Tgf-beta2 and activate SMAD3 signaling."	0.8702
32020674	Journal of clinical laboratory analysis	2020	Circular RNA circMAN2B2 promotes growth and migration of gastric cancer cells by down-regulation of miR-145.	hsa_circ_0069086		hsa_circ_MAN2B2	MAN2B2	gastric carcinoma 	MONDO:0004950	gastric carcinoma	up-regulated	RT-qPCR	"circMAN2B2 is up-regulated in gastric carcinoma tissues and acts as an oncogenic circRNA. Its knockdown suppresses proliferation/survival and migration and promotes apoptosis in SNU-16 and AGS cells, partly by relieving negative regulation on miR-145 and modulating PI3K/AKT and JNK signaling."	0.5434
32020730	Journal of cellular and molecular medicine	2020	CircPRMT5 circular RNA promotes proliferation of colorectal cancer through sponging miR-377 to induce E2F3 expression.			hsa_circ_PRMT5	PRMT5	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH	"CircPRMT5 is up-regulated in colorectal cancer tissues and cell lines and is mainly localized in the cytoplasm. It promotes CRC proliferation and tumor growth by sponging miR-377 to increase E2F3 expression, thereby elevating cell-cycle proteins (CyclinD1 and CDK2), and high CircPRMT5 levels are associated with poorer overall survival."	0.7778
32021287	OncoTargets and therapy	2020	"Circular RNA circHUWE1 Is Upregulated and Promotes Cell Proliferation, Migration and Invasion in Colorectal Cancer by Sponging miR-486."	hsa_circ_0140388		hsa_circ_HUWE1	HUWE1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circHUWE1 is up-regulated in colorectal cancer tissues and mainly localized in the cytoplasm. Functionally, circHUWE1 promotes CRC cell proliferation, colony formation, migration and invasion and suppresses apoptosis, at least in part by sponging miR-486; it also shows potential diagnostic value (ROC AUC 0.732) and correlates with adverse clinicopathologic features."	0.8162
32021297	OncoTargets and therapy	2020	circGFRA1 Enhances NSCLC Progression by Sponging miR-188-3p.			hsa_circ_GFRA1	GFRA1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circGFRA1 is up-regulated in NSCLC tissues and promotes NSCLC cell/tumor proliferation. It functions as a ceRNA by sponging miR-188-3p and activates PI3K/AKT signaling, with downstream increases in proliferation-associated factors (eg, Cyclin A1 and Cyclin B1)."	0.7591
32021419	Cancer management and research	2020	Circular RNA Profiling Reveals That circRNA_104433 Regulates Cell Growth by Targeting miR-497-5p in Gastric Cancer.		hsa_circRNA_104433	hsa_circ_ARPC1B	ARPC1B	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_104433 is up-regulated in gastric cancer and promotes tumor cell cycle progression and proliferation while inhibiting apoptosis. Mechanistically, it binds (sponges) hsa-miR-497-5p to increase CDC25A (and cell-cycle proteins such as CCNB1), and its knockdown suppresses xenograft tumor growth."	0.6829
32021421	Cancer management and research	2020	Diagnostic Significance of Downregulated circMORC3 as a Molecular Biomarker of Hypopharyngeal Squamous Cell Carcinoma: A Pilot Study.	mmu_circ_0006475	circMORC3	mmu_circ_MORC3	MORC3	hypopharyngeal squamous cell carcinoma 	MONDO:0044638	hypopharynx squamous cell carcinoma	down-regulated	RT-qPCR	"circMORC3 (hsa_circ_0001189), derived from MORC3, is down-regulated in HSCC tissues and patient plasma. Its decreased expression correlates with higher T stage and larger tumor size, and it shows diagnostic potential for HSCC by ROC analysis."	0.5261
32021421	Cancer management and research	2020	Diagnostic Significance of Downregulated circMORC3 as a Molecular Biomarker of Hypopharyngeal Squamous Cell Carcinoma: A Pilot Study.	hsa_circ_0001189	circMORC3	hsa_circ_MORC3	MORC3	hypopharyngeal squamous cell carcinoma 	MONDO:0044638	hypopharynx squamous cell carcinoma	down-regulated	RT-qPCR	"circMORC3 (hsa_circ_0001189), derived from MORC3, is down-regulated in HSCC tissues and patient plasma. Its decreased expression correlates with higher T stage and larger tumor size, and it shows diagnostic potential for HSCC by ROC analysis."	0.5261
32021434	Cancer management and research	2020	Circular RNA HIPK3 Promotes EMT of Cervical Cancer Through Sponging miR-338-3p to Up-Regulate HIF-1alpha.			hsa_circ_HIPK3	HIPK3	Cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ-HIPK3 is up-regulated in cervical cancer tissues/cell lines and promotes malignant phenotypes including proliferation, migration/invasion and EMT while inhibiting apoptosis. Mechanistically, it sponges miR-338-3p to relieve repression of HIF-1alpha, forming a circ-HIPK3/miR-338-3p/HIF-1alpha axis."	0.7045
32023009	Cancer medicine	2020	Upregulation of hsa_circ_0007874 suppresses the progression of ovarian cancer by regulating the miR-760/SOCS3 pathway.	hsa_circ_0007874		hsa_circ_MTO1	MTO1	ovarian cancer 	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR	"hsa_circ_0007874 is downregulated in ovarian cancer cell lines and functions as a tumor suppressor. Its overexpression inhibits proliferation, migration, and xenograft tumor growth by sponging miR-760 and relieving repression of SOCS3 (hsa_circ_0007874/miR-760/SOCS3 axis)."	0.5979
32023551	Aging	2020	Circular RNA expression in isoproterenol hydrochloride-induced cardiac hypertrophy.			mmu_circ_Wwp1	wwp1	cardiac hypertrophy 	MONDO:0001302	hypertensive heart disease	down-regulated	RT-qPCR; RNA-seq	"In isoproterenol-induced cardiac hypertrophy in mice, circRNA wwp1 is down-regulated in ventricles. Overexpression of circRNA wwp1 in cardiomyocytes decreases ANF mRNA and miR-23a levels, consistent with an inhibitory role in cardiac hypertrophy."	0.6956
32023551	Aging	2020	Circular RNA expression in isoproterenol hydrochloride-induced cardiac hypertrophy.			mmu_circ_Sh3rf3	sh3rf3	cardiac hypertrophy 	MONDO:0001302	hypertensive heart disease	down-regulated	RT-qPCR; RNA-seq	"mmu_circRNA_sh3rf3 is down-regulated in ventricles of mice with isoproterenol-induced cardiac hypertrophy and was validated by qPCR and Sanger sequencing, but no specific downstream mechanism was reported for this circRNA."	0.6262
32023551	Aging	2020	Circular RNA expression in isoproterenol hydrochloride-induced cardiac hypertrophy.			mmu_circ_Ift81	ift81	cardiac hypertrophy 	MONDO:0001302	hypertensive heart disease	down-regulated	RT-qPCR; RNA-seq	"mmu_circRNA_ift81 is down-regulated in ventricles of mice with isoproterenol-induced cardiac hypertrophy and was validated by qPCR and Sanger sequencing, but no specific downstream mechanism was reported for this circRNA."	0.6262
32023551	Aging	2020	Circular RNA expression in isoproterenol hydrochloride-induced cardiac hypertrophy.			mmu_circ_Trappc9	trappc9	cardiac hypertrophy 	MONDO:0001302	hypertensive heart disease	up-regulated	RT-qPCR; RNA-seq	"mmu_circRNA_trappc9 is up-regulated in ventricles of mice with isoproterenol-induced cardiac hypertrophy and was validated by qPCR and Sanger sequencing, but no specific downstream mechanism was reported for this circRNA."	0.6262
32023551	Aging	2020	Circular RNA expression in isoproterenol hydrochloride-induced cardiac hypertrophy.			mmu_circ_Klc1	klc1	cardiac hypertrophy 	MONDO:0001302	hypertensive heart disease	up-regulated	RT-qPCR; RNA-seq	"mmu_circRNA_klc1 is up-regulated in ventricles of mice with isoproterenol-induced cardiac hypertrophy and was validated by qPCR and Sanger sequencing, but no specific downstream mechanism was reported for this circRNA."	0.6262
32023551	Aging	2020	Circular RNA expression in isoproterenol hydrochloride-induced cardiac hypertrophy.			mmu_circ_20702		cardiac hypertrophy 	MONDO:0001302	hypertensive heart disease	up-regulated	RT-qPCR; RNA-seq	"mmu_circRNA_20702 is up-regulated in ventricles of mice with isoproterenol-induced cardiac hypertrophy and was validated by qPCR and Sanger sequencing, but no specific downstream mechanism was reported for this circRNA."	0.6262
32029690	Aging	2020	Testicular biopsies microarray analysis reveals circRNAs are involved in the pathogenesis of non-obstructive azoospermia.		hsa_circRNA_402130			non-obstructive azoospermia 	MONDO:0100459	azoospermia	down-regulated	RT-qPCR; Microarray	hsa_circRNA_402130 is down-regulated in NOA testicular tissue and was validated by qRT-PCR. The study predicts it may function as a ceRNA by binding let-7 family miRNAs (let-7b-5p/let-7c-5p/let-7i-5p) and potentially affecting downstream spermatogenesis-related genes and pathways.	0.4032
32029690	Aging	2020	Testicular biopsies microarray analysis reveals circRNAs are involved in the pathogenesis of non-obstructive azoospermia.		hsa_circRNA_072697 			non-obstructive azoospermia 	MONDO:0100459	azoospermia	up-regulated	RT-qPCR; Microarray	hsa_circRNA_072697 is up-regulated in NOA testicular tissue and was validated by qRT-PCR. The study predicts it binds miR-23c and miR-182-5p and participates in a circRNA_miRNA_mRNA ceRNA network with hundreds of downstream target genes enriched in multiple signaling pathways.	0.4032
32029690	Aging	2020	Testicular biopsies microarray analysis reveals circRNAs are involved in the pathogenesis of non-obstructive azoospermia.		hsa_circRNA_030050			non-obstructive azoospermia 	MONDO:0100459	azoospermia	up-regulated	RT-qPCR; Microarray	hsa_circRNA_030050 is up-regulated in NOA testicular samples compared with OA and its differential expression was validated by qRT-PCR. No specific mechanism or targets were experimentally defined for this circRNA in the paper.	0.3588
32029690	Aging	2020	Testicular biopsies microarray analysis reveals circRNAs are involved in the pathogenesis of non-obstructive azoospermia.		hsa_circRNA_100812 			non-obstructive azoospermia 	MONDO:0100459	azoospermia	down-regulated	RT-qPCR; Microarray	hsa_circRNA_100812 is down-regulated in NOA testicular samples compared with OA and its differential expression was validated by qRT-PCR. The paper did not further characterize its downstream targets or mechanism.	0.3588
32029690	Aging	2020	Testicular biopsies microarray analysis reveals circRNAs are involved in the pathogenesis of non-obstructive azoospermia.		hsa_circRNA_406168			non-obstructive azoospermia 	MONDO:0100459	azoospermia	down-regulated	RT-qPCR; Microarray	hsa_circRNA_406168 is down-regulated in NOA testicular samples compared with OA and its differential expression was validated by qRT-PCR. The study did not further define its mechanism or targets.	0.3588
32032888	Molecular therapy. Nucleic acids	2020	Upregulation of Circular RNA circATRNL1 to Sensitize Oral Squamous Cell Carcinoma to Irradiation.		circATRNL1 	hsa_circ_ATRNL1	ATRNL1	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR; ISH; RNA-seq	"circATRNL1 is down-regulated in OSCC tissues and cell lines and further decreases after irradiation. Forced upregulation of circATRNL1 sensitizes OSCC cells to irradiation by inhibiting proliferation/colony survival, promoting apoptosis, and inducing G2 arrest, mainly via a ceRNA mechanism (circATRNL1¡úmiR-23a-3p¡úPTEN) that suppresses AKT signaling."	0.8632
32041942	Cell death & disease	2020	circRNA_0000140 suppresses oral squamous cell carcinoma growth and metastasis by targeting miR-31 to inhibit Hippo signaling pathway.	hsa_circ_0000140		hsa_circ_KIAA0907	KIAA0907	Oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR	"circ_0000140 (from KIAA0907) is down-regulated in OSCC and functions as a tumor suppressor. It sponges miR-31 to increase LATS2, inhibit Hippo/YAP signaling output and EMT, thereby reducing proliferation, invasion/migration and lung metastasis, and higher circ_0000140 associates with better survival."	0.8814
32048611	Aging	2020	Circular RNA hsa_circ_0056836 functions an oncogenic gene in hepatocellular carcinoma through modulating miR-766-3p/FOSL2 axis.	hsa_circ_0056836				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0056836 is up-regulated in HCC tissues and cell lines and acts as an oncogenic circRNA. It predominantly localizes to the cytoplasm and sponges miR-766-3p to increase FOSL2, promoting proliferation, migration/invasion and xenograft tumor growth. High expression is associated with worse overall survival and shows diagnostic potential by ROC analysis."	0.8015
32054840	Cell death & disease	2020	Antagonizing circRNA_002581-miR-122-CPEB1 axis alleviates NASH through restoring PTEN-AMPK-mTOR pathway regulated autophagy.	mmu_circ_0001351		mmu_circ_APBB2	APBB2	nonalcoholic steatohepatitis 	MONDO:0007027	metabolic dysfunction-associated steatohepatitis	up-regulated	RT-qPCR	"In mouse NASH models, circRNA_002581 is up-regulated and functions as a ceRNA sponging miR-122 to increase CPEB1. This promotes PTEN_AMPK_mTOR signaling changes that suppress autophagy, thereby aggravating NASH phenotypes; circRNA_002581 knockdown partially restores autophagy and alleviates steatosis-associated injury and inflammation."	0.7632
32059339	Molecular therapy. Nucleic acids	2020	Circular RNA Profiling Reveals Exosomal circ_0006156 as a Novel Biomarker in Papillary Thyroid Cancer.	hsa_circ_0006156		hsa_circ_FNDC3B	FNDC3B	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"circFNDC3B (hsa_circ_0006156), derived from FNDC3B, is up-regulated in PTC tissues, PTC cell lines, and patient serum exosomes. Functionally it promotes proliferation, migration/invasion, cell-cycle progression and tumor growth while inhibiting apoptosis. Mechanistically it acts as a ceRNA sponge for miR-1178/miR-1178-3p, thereby relieving repression of TLR4 and promoting PTC progression."	0.8718
32059341	Molecular therapy. Nucleic acids	2020	circRASSF2 Acts as ceRNA and Promotes Papillary Thyroid Carcinoma Progression through miR-1178/TLR4 Signaling Pathway.	hsa_circ_0059354		hsa_circ_RASSF2	RASSF2	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"circRASSF2 (hsa_circ_0059354), derived from RASSF2, is up-regulated in PTC tissues, PTC cell lines, and patient serum exosomes. It promotes PTC proliferation/migration/invasion and tumor growth while inhibiting apoptosis, mainly by sponging miR-1178 to relieve repression of TLR4 (circRASSF2/miR-1178/TLR4 ceRNA axis)."	0.8401
32061262	Molecular cancer	2020	Circular RNA CRIM1 functions as a ceRNA to promote nasopharyngeal carcinoma metastasis and docetaxel chemoresistance through upregulating FOXQ1.	hsa_circ_0002346		hsa_circ_CRIM1	CRIM1	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; RNA-seq	"circCRIM1 (hsa_circ_0002346) is upregulated in nasopharyngeal carcinoma, especially in patients/cells with high metastatic potential. It promotes metastasis/EMT and docetaxel chemoresistance by sponging miR-422a and derepressing FOXQ1, and high expression predicts poor survival and reduced benefit from docetaxel-containing induction chemotherapy."	0.8942
32063749	Cancer cell international	2020	Construction of a circRNA-miRNA-mRNA network based on competitive endogenous RNA reveals the function of circRNAs in osteosarcoma.	hsa_circ_0000144		hsa_circ_SLAMF6	SLAMF6	osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	Microarray	hsa_circ_0000144 was identified as down-regulated in osteosarcoma based on GEO circRNA microarray data and included among circRNAs used to build a predicted circRNA_miRNA_mRNA ceRNA network.	0.1768
32063749	Cancer cell international	2020	Construction of a circRNA-miRNA-mRNA network based on competitive endogenous RNA reveals the function of circRNAs in osteosarcoma.	hsa_circ_0008433		hsa_circ_PDE4B	PDE4B	osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	Microarray	hsa_circ_0008433 was found down-regulated in osteosarcoma in a circRNA microarray dataset and was used for constructing a predicted circRNA_miRNA_mRNA ceRNA network.	0.1768
32063749	Cancer cell international	2020	Construction of a circRNA-miRNA-mRNA network based on competitive endogenous RNA reveals the function of circRNAs in osteosarcoma.	hsa_circ_0002017		hsa_circ_CRIM1	CRIM1	osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	Microarray	hsa_circ_0002017 is down-regulated in osteosarcoma (microarray) and participates in a predicted circRNA_miRNA_mRNA ceRNA network; it is one of the circRNAs included in a prognosis-related subnetwork built using four survival-associated mRNAs.	0.348
32063749	Cancer cell international	2020	Construction of a circRNA-miRNA-mRNA network based on competitive endogenous RNA reveals the function of circRNAs in osteosarcoma.	hsa_circ_0005442		hsa_circ_CRIM1	CRIM1	osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	Microarray	hsa_circ_0005442 (CRIM1-derived) is down-regulated in osteosarcoma based on GEO circRNA microarray data and was included in the predicted ceRNA network constructed in this study.	0.1768
32063749	Cancer cell international	2020	Construction of a circRNA-miRNA-mRNA network based on competitive endogenous RNA reveals the function of circRNAs in osteosarcoma.	hsa_circ_0061265				osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	Microarray	hsa_circ_0061265 is down-regulated in osteosarcoma (microarray) and is included in the study¡¯s predicted ceRNA network and in the prognosis-related subnetwork linked to four survival-associated mRNAs.	0.348
32063749	Cancer cell international	2020	Construction of a circRNA-miRNA-mRNA network based on competitive endogenous RNA reveals the function of circRNAs in osteosarcoma.	hsa_circ_0061274		hsa_circ_NRIP1	NRIP1	osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	Microarray	hsa_circ_0061274 (NRIP1-derived) is down-regulated in osteosarcoma based on GEO circRNA microarray data and was included in the predicted ceRNA network constructed in this study.	0.1768
32063749	Cancer cell international	2020	Construction of a circRNA-miRNA-mRNA network based on competitive endogenous RNA reveals the function of circRNAs in osteosarcoma.	hsa_circ_0004771		hsa_circ_NRIP1	NRIP1	osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	Microarray	hsa_circ_0004771 (NRIP1-derived) is down-regulated in osteosarcoma based on GEO circRNA microarray data and was included in the predicted ceRNA network constructed in this study.	0.1768
32063749	Cancer cell international	2020	Construction of a circRNA-miRNA-mRNA network based on competitive endogenous RNA reveals the function of circRNAs in osteosarcoma.	hsa_circ_0061276		hsa_circ_NRIP1	NRIP1	osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	Microarray	hsa_circ_0061276 (NRIP1-derived) is down-regulated in osteosarcoma based on GEO circRNA microarray data and was included in the predicted ceRNA network constructed in this study.	0.1768
32063749	Cancer cell international	2020	Construction of a circRNA-miRNA-mRNA network based on competitive endogenous RNA reveals the function of circRNAs in osteosarcoma.	hsa_circ_0077765		hsa_circ_RNF217	RNF217	osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	Microarray	hsa_circ_0077765 is down-regulated in osteosarcoma (microarray) and is included in the study¡¯s predicted ceRNA network and in the prognosis-related subnetwork linked to four survival-associated mRNAs.	0.348
32063749	Cancer cell international	2020	Construction of a circRNA-miRNA-mRNA network based on competitive endogenous RNA reveals the function of circRNAs in osteosarcoma.	hsa_circ_0003945		hsa_circ_UBAP2	UBAP2	osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	Microarray	hsa_circ_0003945 (UBAP2-derived) is down-regulated in osteosarcoma based on GEO circRNA microarray data and was included in the predicted ceRNA network constructed in this study.	0.1768
32063749	Cancer cell international	2020	Construction of a circRNA-miRNA-mRNA network based on competitive endogenous RNA reveals the function of circRNAs in osteosarcoma.	hsa_circ_0088214		hsa_circ_PAPPA	PAPPA	osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	Microarray	hsa_circ_0088214 is down-regulated in osteosarcoma (microarray) and is included in the study¡¯s predicted ceRNA network and in the prognosis-related subnetwork linked to four survival-associated mRNAs.	0.348
32063749	Cancer cell international	2020	Construction of a circRNA-miRNA-mRNA network based on competitive endogenous RNA reveals the function of circRNAs in osteosarcoma.	hsa_circ_0002052		hsa_circ_PAPPA	PAPPA	osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	Microarray	hsa_circ_0002052 is down-regulated in osteosarcoma (microarray) and is included in the study¡¯s predicted ceRNA network and in the prognosis-related subnetwork linked to four survival-associated mRNAs.	0.348
32063749	Cancer cell international	2020	Construction of a circRNA-miRNA-mRNA network based on competitive endogenous RNA reveals the function of circRNAs in osteosarcoma.	hsa_circ_0008792		hsa_circ_PAPPA	PAPPA	osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	Microarray	hsa_circ_0008792 is down-regulated in osteosarcoma (microarray) and is included in the study¡¯s predicted ceRNA network and in the prognosis-related subnetwork linked to four survival-associated mRNAs.	0.348
32063749	Cancer cell international	2020	Construction of a circRNA-miRNA-mRNA network based on competitive endogenous RNA reveals the function of circRNAs in osteosarcoma.	hsa_circ_0088227		hsa_circ_PAPPA	PAPPA	osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	Microarray	hsa_circ_0088227 is down-regulated in osteosarcoma (microarray) and is included in the study¡¯s predicted ceRNA network and in the prognosis-related subnetwork linked to four survival-associated mRNAs.	0.348
32063749	Cancer cell international	2020	Construction of a circRNA-miRNA-mRNA network based on competitive endogenous RNA reveals the function of circRNAs in osteosarcoma.	hsa_circ_0001910		hsa_circ_WWC3	WWC3	osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	Microarray	hsa_circ_0001910 (WWC3-derived) is down-regulated in osteosarcoma based on GEO circRNA microarray data and was included in the predicted ceRNA network constructed in this study.	0.1768
32065779	Aging	2020	Cancer stem cell-specific expression profiles reveal emerging bladder cancer biomarkers and identify circRNA_103809 as an important regulator in bladder cancer.	hsa_circ_0072088	hsa_circRNA_103809	hsa_circ_ZFR	ZFR	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"circRNA_103809 is up-regulated in bladder cancer stem-cell-like populations and promotes bladder cancer progression phenotypes (oncosphere formation/self-renewal, migration, invasion). Mechanistically, it functions as a miR-511 sponge supported by RNA pull-down enrichment of miR-511 and functional knockdown assays."	0.6676
32066649	Medical science monitor : international medical journal of experimental and clinical research	2020	Circular RNA-0001283 Suppresses Breast Cancer Proliferation and Invasion via MiR-187/HIPK3 Axis.	hsa_circ_0001283	circRNA-001283	hsa_circ_HIPK3	HIPK3	breast cancer	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; ISH; Microarray	"circRNA-0001283 is down-regulated in breast cancer tissues/cells and acts as a tumor suppressor. It sponges miR-187 to upregulate HIPK3 and suppress NF-kappaB signaling, thereby inhibiting proliferation/invasion and promoting apoptosis."	0.6956
32072011	Molecular therapy oncolytics	2020	circRNA circFUT8 Upregulates Kr¨¹pple-like Factor 10 to Inhibit the Metastasis of Bladder Cancer via Sponging miR-570-3p.	hsa_circ_0003028	circFUT8	hsa_circ_FUT8	FUT8	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"circFUT8 (hsa_circ_0003028), derived from FUT8, is down-regulated in bladder cancer and mainly localized in the cytoplasm. It suppresses migration, invasion and lymph node metastasis by acting as a ceRNA that sponges miR-570-3p, thereby increasing KLF10 and modulating the KLF10/Slug (EMT-related) program. Low circFUT8 expression is associated with lymph node metastasis, higher histological grade, and worse overall survival."	0.8978
32073729	Journal of cellular and molecular medicine	2020	Circ_PUM1 promotes the development of endometrial cancer by targeting the miR-136/NOTCH3 pathway.	hsa_circ_0000043		hsa_circ_PUM1	PUM1	endometrial cancer 	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR	"circ_PUM1 (circ_0000043) is up-regulated in endometrial cancer tissues and cell lines. It promotes malignant phenotypes (proliferation, migration, invasion) and inhibits apoptosis, and its knockdown suppresses xenograft tumor growth. Mechanistically, circ_PUM1 sponges miR-136 to relieve repression of NOTCH3, thereby activating Notch-related oncogenic effects."	0.6542
32077624	Journal of cellular and molecular medicine	2024	hsa_circ_0000092 promotes hepatocellular carcinoma progression through up-regulating HN1 expression by binding to microRNA-338-3p.	hsa_circ_0000092				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000092 is up-regulated in HCC tissues and cell lines and mainly localizes to the cytoplasm. It promotes HCC progression by acting as a ceRNA that sponges miR-338-3p, thereby up-regulating HN1 and enhancing proliferation, migration, invasion and angiogenesis, and its silencing suppresses tumour growth in vivo."	0.7489
32080097	Medicine	2020	The circ_VCAN with radioresistance contributes to the carcinogenesis of glioma by regulating microRNA-1183.	hsa_circ_0073237	Circ_VCAN	hsa_circ_VCAN	VCAN	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ_VCAN (hsa_circ_0073237; host gene VCAN) is upregulated in radioresistant glioma tissues and promotes radioresistance-associated malignant phenotypes. Mechanistically, it directly binds/sponges miR-1183 to negatively regulate miR-1183, thereby enhancing proliferation, migration and invasion while suppressing apoptosis after irradiation."	0.7032
32082079	Cancer cell international	2020	Hsa_circ_0011385 accelerates the progression of thyroid cancer by targeting miR-361-3p.	hsa_circ_0011385		hsa_circ_EIF3I	EIF3I	thyroid cancer	MONDO:0002108	thyroid cancer	up-regulated	RT-qPCR	"hsa_circ_0011385 is up-regulated in thyroid cancer tissues and promotes malignant phenotypes (proliferation, migration, invasion) while inhibiting cell-cycle arrest and apoptosis. Mechanistically, it sponges miR-361-3p, and its knockdown suppresses xenograft tumor growth and shifts apoptosis/metastasis-related proteins (Bax/caspase-3/TIMP up, MMP2/MMP9 down)."	0.7861
32086008	Redox biology	2020	CircRNA_0001449 disturbs phosphatidylinositol homeostasis and AKT activity by enhancing Osbpl5 translation in transient cerebral ischemia.	hsa_circ_0001449		hsa_circ_OSBPL5	OSBPL5	transient cerebral ischemia 	MONDO:0005264	transient ischemic attack	up-regulated	RT-qPCR; RNA-seq	"circ_0001449 (hsa_circ_0001449) is up-regulated after ischemic injury and functions as a ceRNA that sponges miR-124-3p and miR-32-5p, thereby enhancing Osbpl5 (ORP5) translation. Elevated ORP5 reduces PM PI(3,4,5)P3 and AKT activity, promoting apoptosis/autophagy and contributing to ischemic damage; plasma circ_0001449 is increased in patients, suggesting biomarker potential."	0.7554
32086008	Redox biology	2020	CircRNA_0001449 disturbs phosphatidylinositol homeostasis and AKT activity by enhancing Osbpl5 translation in transient cerebral ischemia.			mmu_circ_Osbpl5	Osbpl5	transient cerebral ischemia 	MONDO:0005264	transient ischemic attack	up-regulated	RT-qPCR; RNA-seq	"circ_0001449 (hsa_circ_0001449) is up-regulated after ischemic injury and functions as a ceRNA that sponges miR-124-3p and miR-32-5p, thereby enhancing Osbpl5 (ORP5) translation. Elevated ORP5 reduces PM PI(3,4,5)P3 and AKT activity, promoting apoptosis/autophagy and contributing to ischemic damage; plasma circ_0001449 is increased in patients, suggesting biomarker potential."	0.7554
32090087	BioMed research international	2020	Circular RNA hsa_circ_0000467 Promotes the Development of Gastric Cancer by Competitively Binding to MicroRNA miR-326-3p.	hsa_circ_0000467		hsa_circ_SKA3	SKA3	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000467 is up-regulated in gastric cancer tissues and cell lines and promotes GC cell proliferation, invasion, and cell-cycle progression. Mechanistically, it sponges miR-326-3p and affects cyclin D1 expression, and miR-326-3p inhibition rescues the effects of hsa_circ_0000467 knockdown."	0.6815
32091150	Journal of clinical laboratory analysis	2020	Next-generation sequencing to investigate circular RNA profiles in the peripheral blood of preterm neonates with bronchopulmonary dysplasia.	hsa_circ_0005577		hsa_circ_FANCL	FANCL	bronchopulmonary dysplasia 	MONDO:0019091	bronchopulmonary dysplasia	up-regulated	RT-qPCR; RNA-seq	"This study identified hsa_circ_0005577 (hsa_circ_FANCL, from host gene FANCL) as up-regulated in moderate-to-severe BPD in peripheral blood. It may contribute to BPD severity/pathogenesis by acting as a predicted miRNA sponge (e.g., let-7) with potential downstream involvement of TGF-beta/RAS/HMGA2-related regulation, and its level correlates with oxygen therapy duration."	0.5963
32091151	Journal of clinical laboratory analysis	2020	CircAP2A2 acts as a ceRNA to participate in infantile hemangiomas progression by sponging miR-382-5p via regulating the expression of VEGFA.		circAP2A2	hsa_circ_AP2A2	AP2A2	infantile hemangiomas 	MONDO:0006500	hemangioma	up-regulated	RT-qPCR	"CircAP2A2 is up-regulated in infantile hemangiomas and mainly localizes in the cytoplasm. It promotes IH cell proliferation, migration and invasion by sponging miR-382-5p and relieving repression of VEGFA (circAP2A2/miR-382-5p/VEGFA ceRNA axis)."	0.7968
32094325	Cell death & disease	2020	Circular RNA circRNF20 promotes breast cancer tumorigenesis and Warburg effect through miR-487a/HIF-1alpha/HK2.	hsa_circ_0087784	circRNF20	hsa_circ_RNF20	RNF20	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circRNF20 (hsa_circ_0087784), derived from RNF20, is up-regulated in breast cancer and promotes tumor cell proliferation and glycolytic Warburg effect while inhibiting apoptosis. It functions as a ceRNA by sponging miR-487a to increase HIF-1alpha, which transcriptionally activates HK2, thereby enhancing glycolysis and tumor growth; high circRNF20 predicts poor prognosis."	0.8806
32096481	Aging	2020	The circular RNA NT5E promotes non-small cell lung cancer cell growth via sponging microRNA-134.		circNT5E	hsa_circ_NT5E	NT5E	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circNT5E is up-regulated in human NSCLC tissues and cells and mainly localizes to the cytoplasm. Functional assays show circNT5E promotes NSCLC cell growth/proliferation/migration and suppresses apoptosis, largely by sponging miR-134."	0.6601
32099403	OncoTargets and therapy	2020	Circular RNA circ_0006282 Contributes to the Progression of Gastric Cancer by Sponging miR-155 to Upregulate the Expression of FBXO22.	hsa_circ_0006282				gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_0006282 is up-regulated in gastric cancer tissues and cell lines and promotes malignant behaviors (proliferation, migration/invasion, and xenograft growth). Mechanistically, it mainly localizes in the cytoplasm and functions as a ceRNA that sponges miR-155, thereby upregulating FBXO22 to drive GC progression."	0.8034
32099459	Cancer management and research	2019	circPCNX and Pecanex Promote Hepatocellular Carcinoma Cell Viability by Inhibiting miR-506.	hsa_circ_0102533		hsa_circ_PCNX	PCNX	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circPCNX is up-regulated in HCC tissues and promotes HCC cell viability in vitro by acting as a miR-506 sponge, thereby increasing expression of miR-506 target oncogenes (e.g., Snail2 and YAP1). High circPCNX expression is associated with worse DFS and OS in HCC patients."	0.8162
32099530	Cancer cell international	2020	Hsa_circ_0003159 inhibits gastric cancer progression by regulating miR-223-3p/NDRG1 axis.	hsa_circ_0003159		hsa_circ_CACNA2D1	CACNA2D1	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"In gastric cancer, hsa_circ_0003159 is down-regulated and acts as a tumor suppressor by inhibiting proliferation/migration/invasion and promoting apoptosis. Mechanistically, it functions as a ceRNA that sponges miR-223-3p to increase NDRG1 expression, thereby suppressing tumor growth in vitro and in a xenograft model. Low hsa_circ_0003159 expression correlates with worse OS and DFS."	0.7701
32099534	"Journal of inflammation (London, England)"	2020	Circular RNA-CDR1as acts as the sponge of microRNA-641 to promote osteoarthritis progression.		CDR1as	hsa_circ_CDR1AS	CDR1as	osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circRNA-CDR1as is up-regulated in OA chondrocytes and promotes OA progression. It sponges miR-641, derepressing FGF-2 and activating MEK/ERK signaling, which increases MMP13 and IL-6 and reduces type II collagen, thereby enhancing ECM catabolism and inflammation."	0.6903
32099751	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2020	Circ-MALAT1 Functions as Both an mRNA Translation Brake and a microRNA Sponge to Promote Self-Renewal of Hepatocellular Cancer Stem Cells.	hsa_circ_0002082		hsa_circ_MALAT1	MALAT1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"Circ-MALAT1 is up-regulated in hepatocellular carcinoma CSCs and promotes CSC self-renewal and xenograft tumor growth. Mechanistically, it inhibits PAX5 translation by forming a ribosome_circRNA_PAX5 mRNA ternary complex (mRNA braking) and also sponges miR-6887-3p to upregulate JAK2 and activate JAK2/STAT3 signaling."	0.8421
32104074	Cancer management and research	2020	CircHIPK3 Promotes Gemcitabine (GEM) Resistance in Pancreatic Cancer Cells by Sponging miR-330-5p and Targets RASSF1.			hsa_circ_HIPK3	HIPK3	pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in pancreatic cancer and further increased in gemcitabine-resistant contexts. It promotes GEM resistance and malignant phenotypes by sponging miR-330-5p to regulate the downstream target RASSF1, affecting proliferation, migration/invasion, EMT and apoptosis."	0.8005
32107851	Thoracic cancer	2020	Circ-IGF1R inhibits cell invasion and migration in non-small cell lung cancer.	hsa_circ_0005035		hsa_circ_IGF1R	IGF1R	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	"circ-IGF1R (hsa_circ_0005035) is down-regulated in NSCLC tissues and cell lines and its overexpression suppresses NSCLC cell migration and invasion. Mechanistically, it is proposed to inhibit Wnt/beta-catenin signaling via a circ-IGF1R/miR-1270/VANGL2 regulatory axis."	0.7165
32108138	Scientific reports	2020	A comprehensive analysis of coding and non-coding transcriptomic changes in cutaneous squamous cell carcinoma.		CDR1as	hsa_circ_CDR1	CDR1	Cutaneous squamous cell carcinoma 	MONDO:0002529	skin squamous cell carcinoma	down-regulated	RNA-seq	"CDR1as is significantly down-regulated in cutaneous squamous cell carcinoma versus healthy skin, with downregulation also detected in actinic keratosis in the validation cohort. The paper does not experimentally define its mechanism in cSCC, but discusses prior evidence that CDR1as can interact with miR-7 and modulate EGFR/KLF4 in other cancers."	0.2995
32108138	Scientific reports	2020	A comprehensive analysis of coding and non-coding transcriptomic changes in cutaneous squamous cell carcinoma.		circ_IFFO2	hsa_circ_IFFO2	IFFO2	Cutaneous squamous cell carcinoma 	MONDO:0002529	skin squamous cell carcinoma	down-regulated	RNA-seq	"circ_IFFO2 is a novel (not circBase-annotated) circRNA derived from IFFO2 and is significantly down-regulated in cSCC compared with healthy skin, with reduced expression already detectable in actinic keratosis. The study validates its back-splice junction by divergent-primer PCR and Sanger sequencing, but does not define a downstream mechanism."	0.5129
32108138	Scientific reports	2020	A comprehensive analysis of coding and non-coding transcriptomic changes in cutaneous squamous cell carcinoma.		circ_TNFRSF21	hsa_circ_TNFRSF21	TNFRSF21	Cutaneous squamous cell carcinoma 	MONDO:0002529	skin squamous cell carcinoma	up-regulated	RNA-seq	"circ_TNFRSF21 is significantly up-regulated in cSCC versus healthy skin and is validated in an expanded clinical cohort by NanoString. The paper suggests its expression may be co-regulated with its host gene TNFRSF21, but does not report a specific downstream mechanism."	0.2995
32108138	Scientific reports	2020	A comprehensive analysis of coding and non-coding transcriptomic changes in cutaneous squamous cell carcinoma.		circ_METRNL	hsa_circ_METRNL	METRNL	Cutaneous squamous cell carcinoma 	MONDO:0002529	skin squamous cell carcinoma	unknown	Microarray	circ_METRNL is a novel circRNA candidate whose back-splice junction is experimentally confirmed by divergent-primer PCR and Sanger sequencing in this study. The article does not report its differential expression direction or functional role in cSCC.	0.385
32108138	Scientific reports	2020	A comprehensive analysis of coding and non-coding transcriptomic changes in cutaneous squamous cell carcinoma.		circ_POF1B	hsa_circ_POF1B	POF1B	Cutaneous squamous cell carcinoma 	MONDO:0002529	skin squamous cell carcinoma	unknown	Microarray	"circ_POF1B is a novel circRNA candidate (not annotated in circBase) whose back-splice junction is confirmed by divergent-primer PCR and Sanger sequencing. The study indicates it is among novel circRNAs from host genes that are strongly downregulated in cSCC, but does not provide a specific validated fold-change or functional mechanism for circ_POF1B."	0.385
32110054	OncoTargets and therapy	2020	"Circ_0058124 Upregulates MAPK1 Expression to Promote Proliferation, Metastasis and Metabolic Abilities in Thyroid Cancer Through Sponging miR-940."	hsa_circ_0058124		hsa_circ_FN1	FN1	Thyroid cancer 	MONDO:0002108	thyroid cancer	up-regulated	RT-qPCR	"circ_0058124 is up-regulated in thyroid cancer tissues/cells and mainly localizes to the cytoplasm. It promotes TC cell proliferation, migration/invasion and metabolic capacity by sponging miR-940 to upregulate MAPK1, and its knockdown suppresses xenograft tumor growth."	0.8562
32110057	OncoTargets and therapy	2020	circHIPK3 Promotes Cell Proliferation and Migration of Gastric Cancer by Sponging miR-107 and Regulating BDNF Expression.		hsa_circRNA_100782	hsa_circ_HIPK3	HIPK3	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circHIPK3 is upregulated in gastric cancer tissues and cell lines and predominantly localizes to the cytoplasm. It promotes GC cell proliferation and migration and enhances tumor growth in xenografts, mainly by sponging miR-107 to increase BDNF expression (circHIPK3/miR-107/BDNF axis)."	0.8429
32110097	Cancer management and research	2020	circPVT1 Facilitates Invasion and Metastasis by Regulating miR-205-5p/c-FLIP Axis in Osteosarcoma.			hsa_circ_PVT1	PVT1	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circPVT1 is up-regulated in osteosarcoma tissues and cell lines and promotes proliferation, migration, invasion and EMT in vitro. Mechanistically, it functions as a ceRNA by sponging miR-205-5p, thereby relieving miR-205-5p-mediated suppression of c-FLIP (circPVT1/miR-205-5p/c-FLIP axis)."	0.6521
32111227	Molecular cancer	2020	CircMUC16 promotes autophagy of epithelial ovarian cancer via interaction with ATG13 and miR-199a.	hsa_circ_0049116		hsa_circ_MUC16	MUC16	epithelial ovarian cancer 	MONDO:0005140	ovarian carcinoma	up-regulated	RT-qPCR; RNA-seq	"circMUC16 (hsa_circ_0049116), derived from MUC16, is up-regulated in EOC tissues and patient serum. It promotes EOC autophagy flux and malignant phenotypes (proliferation, invasion/metastasis) by sponging miR-199a-5p to de-repress Beclin1 and RUNX1, forms a RUNX1_circMUC16 positive feedback loop, and also directly binds ATG13 to enhance its expression."	0.8023
32114390	EBioMedicine	2020	CircRNA-CIDN mitigated compression loading-induced damage in human nucleus pulposus cells via miR-34a-5p/SIRT1 axis.	hsa_circ_0044722		hsa_circ_TRIM25	TRIM25	intervertebral disc degeneration 	MONDO:0011385	intervertebral disk degenerative disorder	down-regulated	RT-qPCR; Microarray	"circRNA-CIDN (hsa_circ_0044722, from TRIM25) is down-regulated under compression and in degenerative NP tissues. Its overexpression protects NP cells and ex vivo discs by reducing apoptosis and ECM catabolism. Mechanistically, it acts as a ceRNA sponge for miR-34a-5p, thereby relieving repression of SIRT1."	0.8508
32118311	Journal of clinical laboratory analysis	2020	CircRNA_103762 promotes multidrug resistance in NSCLC by targeting DNA damage inducible transcript 3 (CHOP).		circRNA_103762			non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circRNA_103762 is up-regulated in NSCLC tissues and cell lines and is associated with worse overall survival. Functionally, its knockdown suppresses proliferation/migration/invasion and reduces multidrug resistance, at least partly by relieving inhibition of CHOP expression."	0.6719
32127416	Genome research	2020	"Genome-wide, integrative analysis of circular RNA dysregulation and the corresponding circular RNA-microRNA-mRNA regulatory axes in autism."		circARID1A	hsa_circ_ARID1A	ARID1A	autism spectrum disorder 	MONDO:0005258	autism spectrum disorder	up-regulated	RT-qPCR; RNA-seq	"circARID1A is up-regulated in ASD cortex and predominantly cytoplasmic. It sponges miR-204-3p, thereby modulating expression of multiple miR-204-3p target genes including ASD risk genes such as NLGN1, STAG1, HSD11B1, VIP, and UBA6."	0.7561
32127962	Journal of Cancer	2020	Curcumin Enhances Radiosensitization of Nasopharyngeal Carcinoma via Mediating Regulation of Tumor Stem-like Cells by a CircRNA Network.		hsa_circRNA_102115			nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	dysregulated	RT-qPCR; Microarray	"hsa_circRNA_102115 is implicated in NPC CNE-2 cell radioresistance and curcumin-enhanced radiosensitization. The study supports a circRNA-miRNA-mRNA network where hsa_circRNA_102115 is linked to hsa-miR-335-3p and downstream targets MAPK1/IGF1R, with curcumin restoring radiosensitivity through the hsa_circRNA_102115_hsa-miR-335-3p_MAPK1 axis."	0.9082
32133664	Cell biochemistry and function	2020	CircRNA_0005075 suppresses carcinogenesis via regulating miR-431/p53/epithelial-mesenchymal transition axis in gastric cancer.	hsa_circ_0005075				gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circRNA_0005075 is up-regulated in gastric cancer and higher expression associates with worse overall survival. Functionally, its knockdown suppresses proliferation and metastasis of GC cells by sponging miR-431, leading to increased p53 and inhibition of EMT-related changes."	0.7113
32139670	Cell death & disease	2020	Silencing of circRACGAP1 sensitizes gastric cancer cells to apatinib via modulating autophagy by targeting miR-3657 and ATG7.		hsa_circRNA004582	hsa_circ_RACGAP1	RACGAP1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"In gastric cancer under apatinib treatment, circRACGAP1 is induced and functions as a ceRNA sponge for miR-3657, thereby increasing ATG7 and promoting autophagy. Silencing circRACGAP1 suppresses autophagy and increases apoptosis, sensitizing GC cells and xenografts to apatinib."	0.8572
32145677	Molecular therapy. Nucleic acids	2020	Comprehensive RNA Sequencing in Adenoma-Cancer Transition Identified Predictive Biomarkers and Therapeutic Targets of Human CRC.	hsa_circ_0049487				colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0049487 is downregulated in both colorectal adenoma and colorectal cancer tissues versus adjacent normal tissues. It is part of a predicted circRNA-related ceRNA network (including sponging hsa-miR-17-5p and hsa-miR-20a-5p to affect downstream mRNAs such as ALPK3/FOXN3/TCF21) and shows diagnostic value for discriminating adenoma/CRC from normal tissues.	0.5047
32145677	Molecular therapy. Nucleic acids	2020	Comprehensive RNA Sequencing in Adenoma-Cancer Transition Identified Predictive Biomarkers and Therapeutic Targets of Human CRC.	hsa_circ_0066875				colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0066875 is downregulated in both colorectal adenoma and colorectal cancer tissues versus adjacent normal tissues. It is predicted to act as a ceRNA by binding hsa-miR-135b-5p and potentially regulating targets including ADCY5, ALPK3, SDK1, MID2, TNS1, RBPMS, GNAZ and RRAS, and it shows diagnostic value for adenoma-to-cancer transition."	0.5047
32145677	Molecular therapy. Nucleic acids	2020	Comprehensive RNA Sequencing in Adenoma-Cancer Transition Identified Predictive Biomarkers and Therapeutic Targets of Human CRC.	hsa_circ_0007444				colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0007444 is downregulated in both colorectal adenoma and colorectal cancer tissues versus adjacent normal tissues. It is predicted to function as a ceRNA by binding hsa-miR-135b-5p and potentially regulating multiple mRNA targets, and it shows diagnostic value for discriminating adenoma/CRC from normal tissues."	0.5047
32149089	BioMed research international	2020	"Elevated hsa_circRNA_101015, hsa_circRNA_101211, and hsa_circRNA_103470 in the Human Blood: Novel Biomarkers to Early Diagnose Acute Pancreatitis."	hsa_circ_0000378	hsa_circRNA_101015	hsa_circ_LRP6	LRP6	acute pancreatitis 	MONDO:0006515	acute pancreatitis	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_101015 is up-regulated in whole blood of acute pancreatitis patients, increases with disease severity, and declines after treatment. It shows diagnostic value for early AP (ROC AUC reported) and is predicted in a ceRNA network to potentially sponge miRNAs (e.g., hsa-miR-135a/b and hsa-miR-543)."	0.5963
32149089	BioMed research international	2020	"Elevated hsa_circRNA_101015, hsa_circRNA_101211, and hsa_circRNA_103470 in the Human Blood: Novel Biomarkers to Early Diagnose Acute Pancreatitis."	hsa_circ_0029407	hsa_circRNA_101211	hsa_circ_GLT1D1	GLT1D1	acute pancreatitis 	MONDO:0006515	acute pancreatitis	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_101211 is up-regulated in whole blood of acute pancreatitis patients, rises with disease severity (healthy vs MAP vs SAP), and decreases after treatment. It has diagnostic value for early AP (ROC AUC reported) and was included in a constructed ceRNA network, though specific miRNA partners were not detailed for this circRNA in the text."	0.5963
32149089	BioMed research international	2020	"Elevated hsa_circRNA_101015, hsa_circRNA_101211, and hsa_circRNA_103470 in the Human Blood: Novel Biomarkers to Early Diagnose Acute Pancreatitis."	hsa_circ_0067301	hsa_circRNA_103470	hsa_circ_PLXND1	PLXND1	acute pancreatitis 	MONDO:0006515	acute pancreatitis	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_103470 is up-regulated in whole blood of acute pancreatitis patients, increases with disease severity, and decreases after treatment. It has diagnostic value for early AP (ROC AUC reported) and was included in a constructed ceRNA network, though specific miRNA partners were not detailed for this circRNA in the text."	0.5963
32149089	BioMed research international	2020	"Elevated hsa_circRNA_101015, hsa_circRNA_101211, and hsa_circRNA_103470 in the Human Blood: Novel Biomarkers to Early Diagnose Acute Pancreatitis."	hsa_circ_0002532	hsa_circRNA_002532			acute pancreatitis 	MONDO:0006515	acute pancreatitis	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_002532 is down-regulated in whole blood from mild acute pancreatitis patients versus healthy controls and was confirmed by RT-qPCR after microarray screening. It was also included in a bioinformatically constructed ceRNA network, but no specific downstream miRNA/mRNA axis was experimentally validated."	0.5135
32149089	BioMed research international	2020	"Elevated hsa_circRNA_101015, hsa_circRNA_101211, and hsa_circRNA_103470 in the Human Blood: Novel Biomarkers to Early Diagnose Acute Pancreatitis."	hsa_circ_0059665	hsa_circRNA_059665 	hsa_circ_ABHD12	ABHD12	acute pancreatitis 	MONDO:0006515	acute pancreatitis	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_059665 is down-regulated in whole blood from mild acute pancreatitis patients versus healthy controls and was confirmed by RT-qPCR after microarray screening. In the constructed ceRNA network, it is predicted to target miRNAs including hsa-miR-122 and hsa-miR-148a, suggesting a potential miRNA-sponge role without direct experimental validation of downstream targets."	0.5135
32149089	BioMed research international	2020	"Elevated hsa_circRNA_101015, hsa_circRNA_101211, and hsa_circRNA_103470 in the Human Blood: Novel Biomarkers to Early Diagnose Acute Pancreatitis."	hsa_circ_0001626	hsa_circRNA_104156	hsa_circ_BACH2	BACH2	acute pancreatitis 	MONDO:0006515	acute pancreatitis	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_104156 is down-regulated in whole blood from mild acute pancreatitis patients versus healthy controls and was confirmed by RT-qPCR after microarray screening. In the constructed ceRNA network, it is predicted to sponge hsa-miR-148a, suggesting a potential ceRNA role without direct mechanistic validation."	0.5135
32154171	Frontiers in oncology	2020	Lcn2-derived Circular RNA (hsa_circ_0088732) Inhibits Cell Apoptosis and Promotes EMT in Glioma via the miR-661/RAB3D Axis.	hsa_circ_0088732		hsa_circ_Lcn2	Lcn2	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; ISH	"hsa_circ_0088732 (Lcn2-derived) is up-regulated in glioma and mainly localized in the cytoplasm. It promotes glioma progression by acting as a ceRNA sponge for miR-661, thereby increasing RAB3D and enhancing migration/invasion/EMT while inhibiting apoptosis, including in a nude-mouse xenograft model."	0.8399
32154178	Frontiers in oncology	2020	A Dual-Circular RNA Signature as a Non-invasive Diagnostic Biomarker for Gastric Cancer.	hsa_circ_0021087		hsa_circ_LMO1	LMO1	Gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0021087 is down-regulated in gastric cancer tissues/cells/plasma and shows postoperative rebound in plasma, supporting its use as a non-invasive diagnostic biomarker. Functionally, it promotes GC cell proliferation and its knockdown increases migration, and it is predicted to act via a circRNA_miRNA_mRNA ceRNA network involving miR-184/miR-1276/miR-450b-3p."	0.6719
32154178	Frontiers in oncology	2020	A Dual-Circular RNA Signature as a Non-invasive Diagnostic Biomarker for Gastric Cancer.	hsa_circ_0005051				Gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0005051 is down-regulated in gastric cancer tissues/cells/plasma and provides diagnostic value in plasma (AUC 0.73) as part of a dual-circRNA signature with hsa_circ_0021087. Its preoperative versus postoperative plasma levels do not show a significant difference, and its mechanistic role is only presented as a predicted ceRNA network."	0.5047
32155686	Journal of cellular and molecular medicine	2020	Screening and functional prediction of differentially expressed circRNAs in proliferative human aortic smooth muscle cells.	hsa_circ_0002579				vascular remodelling diseases	MONDO:0005385	vascular disorder	up-regulated	Microarray	"hsa_circ_0002579 is up-regulated in proliferative HASMCs and functions as a pro-proliferative factor. It is predicted to act as a ceRNA (miRNA sponge) and may promote proliferation by increasing targets such as HMGA2, with enrichment in TGF-beta receptor, Ras, and AMPK signaling-related gene sets."	0.3963
32155686	Journal of cellular and molecular medicine	2020	Screening and functional prediction of differentially expressed circRNAs in proliferative human aortic smooth muscle cells.	hsa_circ_0004872				vascular remodelling diseases	MONDO:0005385	vascular disorder	up-regulated	RT-qPCR; Microarray	"hsa_circ_0004872 is up-regulated in proliferative HASMCs and is predicted to act as a ceRNA by sponging hsa-miR-424-5p, potentially affecting targets such as RASAL2/ABL2 and proliferation-related pathways (e.g., Ras signaling) based on network/enrichment analyses."	0.2465
32155686	Journal of cellular and molecular medicine	2020	Screening and functional prediction of differentially expressed circRNAs in proliferative human aortic smooth muscle cells.	hsa_circ_0006371				vascular remodelling diseases	MONDO:0005385	vascular disorder	unknown	Microarray	"hsa_circ_0006371 is highlighted as a key DEcircRNA in proliferative vs quiescent HASMCs and is predicted (via network analysis) to function as a ceRNA by binding miRNAs such as hsa-miR-24-3p and hsa-miR-424-5p, potentially influencing Wnt and MAPK-related targets (e.g., DVL3, MAP3K13)."	0.1768
32155686	Journal of cellular and molecular medicine	2020	Screening and functional prediction of differentially expressed circRNAs in proliferative human aortic smooth muscle cells.	hsa_circ_0040705				vascular remodelling diseases	MONDO:0005385	vascular disorder	up-regulated	RT-qPCR; Microarray	"hsa_circ_0040705 is up-regulated in proliferative HASMCs and is predicted to act as a ceRNA by sponging hsa-miR-204-5p, potentially impacting targets such as ELK4 and enrichment in Wnt/MAPK-related pathways based on network analyses."	0.2465
32157748	Journal of clinical laboratory analysis	2020	CircRNA hsa_circ_0013958 may contribute to the development of ovarian cancer by affecting epithelial-mesenchymal transition and apoptotic signaling pathways.	hsa_circ_0013958				ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"hsa_circ_0013958 is up-regulated in ovarian cancer tissues and cell lines and is associated with advanced FIGO stage and lymph node metastasis. Silencing hsa_circ_0013958 inhibits proliferation, migration and invasion while promoting apoptosis, and it modulates EMT- and apoptosis-related protein markers (E-cadherin/Vimentin, Bax/Bcl-2). It shows potential diagnostic value (ROC AUC 0.912)."	0.6194
32158226	OncoTargets and therapy	2020	Hsa_circ_RNA_0011780 Represses the Proliferation and Metastasis of Non-Small Cell Lung Cancer by Decreasing FBXW7 via Targeting miR-544a.	hsa_circ_0011780		hsa_circ_MACF1	MACF1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_11780 is down-regulated in NSCLC and acts as a tumor suppressor by inhibiting proliferation, migration/invasion and promoting apoptosis. Mechanistically, it sponges miR-544a and modulates the miR-544a_FBXW7 protein axis, and low expression is associated with metastasis and worse overall survival."	0.7976
32158357	Cancer cell international	2020	Hsa_circ_0137008 suppresses the malignant phenotype in colorectal cancer by acting as a microRNA-338-5p sponge.	hsa_circ_0137008	circ_0137008			colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"hsa_circ_0137008 is down-regulated in colorectal cancer tissues and cell lines. Its overexpression suppresses CRC cell proliferation, migration, invasion and EMT and inhibits xenograft tumor growth, mainly by sponging miR-338-5p and antagonizing miR-338-5p-driven malignant effects."	0.7099
32158464	Frontiers in genetics	2020	Hsa_Circ_0007843 Acts as a mIR-518c-5p Sponge to Regulate the Migration and Invasion of Colon Cancer SW480 Cells.	hsa_circ_0007843		hsa_circ_ARHGAP32	ARHGAP32	colon cancer	MONDO:0021063	malignant colon neoplasm	up-regulated	RT-qPCR; Microarray	"hsa_circ_0007843 is up-regulated in colon cancer tissues and highly expressed in SW480 cells. It promotes colony formation, migration/invasion, and xenograft tumor growth by functioning as a ceRNA sponge for miR-518c-5p, thereby relieving miR-518c-5p-mediated repression and increasing MMP2 expression/translation."	0.6829
32158464	Frontiers in genetics	2020	Hsa_Circ_0007843 Acts as a mIR-518c-5p Sponge to Regulate the Migration and Invasion of Colon Cancer SW480 Cells.	hsa_circ_0010575		hsa_circ_HSPG2	HSPG2	colon cancer	MONDO:0021063	malignant colon neoplasm	up-regulated	RT-qPCR	"hsa_circ_0010575 was experimentally validated by RT-qPCR to be up-regulated in colon cancer tissues versus paired controls, but no functional or mechanistic experiments were reported for this circRNA in the study."	0.2995
32158464	Frontiers in genetics	2020	Hsa_Circ_0007843 Acts as a mIR-518c-5p Sponge to Regulate the Migration and Invasion of Colon Cancer SW480 Cells.	hsa_circ_0007331		hsa_circ_ACAP2	ACAP2	colon cancer	MONDO:0021063	malignant colon neoplasm	up-regulated	RT-qPCR	hsa_circ_0007331 was validated by RT-qPCR as up-regulated in colon cancer tissues versus paired controls; no downstream functional/mechanistic experiments for this circRNA were reported.	0.2995
32158464	Frontiers in genetics	2020	Hsa_Circ_0007843 Acts as a mIR-518c-5p Sponge to Regulate the Migration and Invasion of Colon Cancer SW480 Cells.	hsa_circ_0001615		hsa_circ_PHIP	PHIP	colon cancer	MONDO:0021063	malignant colon neoplasm	up-regulated	RT-qPCR	hsa_circ_0001615 was validated by RT-qPCR as up-regulated in colon cancer tissues versus paired controls; the paper did not further characterize its function or molecular mechanism.	0.2995
32160412	Journal of cellular and molecular medicine	2020	Circular RNA YAP1 acts as the sponge of microRNA-21-5p to secure HK-2 cells from ischaemia/reperfusion-induced injury.	hsa_circ_0024093		hsa_circ_YAP1	YAP1	acute kidney injury 	MONDO:0002492	acute kidney injury	down-regulated	RT-qPCR	"In AKI/I-R injury models, circYAP1 is down-regulated in patient whole blood and I/R-treated HK-2 cells. circYAP1 overexpression protects HK-2 cells by promoting viability, reducing apoptosis and inflammatory injury (cytokines/ROS) through sponging miR-21-5p and activating the PI3K/AKT/mTOR pathway."	0.6521
32161468	OncoTargets and therapy	2020	Circular RNA circ_0001105 Inhibits Progression and Metastasis of Osteosarcoma by Sponging miR-766 and Activating YTHDF2 Expression.	hsa_circ_0001105				osteosarcoma 	MONDO:0009807	osteosarcoma	dysregulated	RT-qPCR; ISH	"The study reports that circ_0001105 suppresses osteosarcoma malignant behaviors (proliferation, migration/invasion and xenograft growth). Mechanistically, circ_0001105 functions as a ceRNA that sponges miR-766, thereby relieving miR-766-mediated repression of YTHDF2."	0.7739
32161614	Frontiers in genetics	2020	A Comprehensive Analysis Identified the Key Differentially Expressed Circular Ribonucleic Acids and Methylation-Related Function in Pheochromocytomas and Paragangliomas.	hsa_circ_0000567				pheochromocytomas and paragangliomas 	MONDO:0017366	hereditary pheochromocytoma-paraganglioma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000567 is up-regulated in PCC/PGL tumor tissues (and also higher in patient peripheral blood) and is proposed to act as an RNA sponge. It may bind hsa-miR-96-3p and be linked to regulation of histone methylation, suggesting potential biomarker utility in PCC/PGLs."	0.4032
32161614	Frontiers in genetics	2020	A Comprehensive Analysis Identified the Key Differentially Expressed Circular Ribonucleic Acids and Methylation-Related Function in Pheochromocytomas and Paragangliomas.	hsa_circ_0002897				pheochromocytomas and paragangliomas 	MONDO:0017366	hereditary pheochromocytoma-paraganglioma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0002897 is up-regulated in PCC/PGL tumor tissues (and higher in patient peripheral blood) and is proposed to function as an RNA sponge. It is implicated in circRNA-miRNA regulatory networks associated with histone methylation in PCC/PGL pathogenesis.	0.4032
32161614	Frontiers in genetics	2020	A Comprehensive Analysis Identified the Key Differentially Expressed Circular Ribonucleic Acids and Methylation-Related Function in Pheochromocytomas and Paragangliomas.	hsa_circ_0004473				pheochromocytomas and paragangliomas 	MONDO:0017366	hereditary pheochromocytoma-paraganglioma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0004473 is up-regulated in PCC/PGL tumor tissues (and higher in patient peripheral blood) and is proposed to act as an RNA sponge within circRNA-miRNA networks. It is implicated in regulating histone methylation-related processes during PCC/PGL pathogenesis.	0.4032
32161614	Frontiers in genetics	2020	A Comprehensive Analysis Identified the Key Differentially Expressed Circular Ribonucleic Acids and Methylation-Related Function in Pheochromocytomas and Paragangliomas.	hsa_circ_0000972				pheochromocytomas and paragangliomas 	MONDO:0017366	hereditary pheochromocytoma-paraganglioma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000972 is significantly up-regulated in PCC/PGL tumor tissues compared with adjacent tissues, validated by RT-qPCR. The paper does not provide a specific mechanism or functional role for this circRNA beyond differential expression."	0.3588
32161614	Frontiers in genetics	2020	A Comprehensive Analysis Identified the Key Differentially Expressed Circular Ribonucleic Acids and Methylation-Related Function in Pheochromocytomas and Paragangliomas.	hsa_circ_0000825				pheochromocytomas and paragangliomas 	MONDO:0017366	hereditary pheochromocytoma-paraganglioma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000825 is significantly up-regulated in PCC/PGL tumor tissues compared with adjacent tissues, validated by RT-qPCR. No specific mechanism or downstream axis is provided for this circRNA in the text."	0.3588
32161614	Frontiers in genetics	2020	A Comprehensive Analysis Identified the Key Differentially Expressed Circular Ribonucleic Acids and Methylation-Related Function in Pheochromocytomas and Paragangliomas.	hsa_circ_0003265				pheochromocytomas and paragangliomas 	MONDO:0017366	hereditary pheochromocytoma-paraganglioma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0003265 is significantly up-regulated in PCC/PGL tumor tissues versus adjacent tissues and was validated by RT-qPCR among the top differentially expressed circRNAs. No specific mechanism or pathway is assigned to it in the provided text.	0.3588
32161614	Frontiers in genetics	2020	A Comprehensive Analysis Identified the Key Differentially Expressed Circular Ribonucleic Acids and Methylation-Related Function in Pheochromocytomas and Paragangliomas.	hsa_circ_0007279				pheochromocytomas and paragangliomas 	MONDO:0017366	hereditary pheochromocytoma-paraganglioma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0007279 is significantly up-regulated in PCC/PGL tumor tissues compared with adjacent tissues and was validated by RT-qPCR among top candidates. The article does not provide a specific functional mechanism for it in the provided text.	0.3588
32161614	Frontiers in genetics	2020	A Comprehensive Analysis Identified the Key Differentially Expressed Circular Ribonucleic Acids and Methylation-Related Function in Pheochromocytomas and Paragangliomas.	hsa_circ_0056892				pheochromocytomas and paragangliomas 	MONDO:0017366	hereditary pheochromocytoma-paraganglioma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0056892 is markedly down-regulated in PCC/PGL tumor tissues compared with adjacent tissues and was validated by RT-qPCR as part of the top differentially expressed circRNAs. The article does not provide a specific mechanism for this circRNA in the provided text.	0.3588
32161614	Frontiers in genetics	2020	A Comprehensive Analysis Identified the Key Differentially Expressed Circular Ribonucleic Acids and Methylation-Related Function in Pheochromocytomas and Paragangliomas.	hsa_circ_0019773				pheochromocytomas and paragangliomas 	MONDO:0017366	hereditary pheochromocytoma-paraganglioma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0019773 is down-regulated in PCC/PGL tumor tissues compared with adjacent tissues and was validated by RT-qPCR. No specific function or mechanism is described for this circRNA in the provided text.	0.3588
32161614	Frontiers in genetics	2020	A Comprehensive Analysis Identified the Key Differentially Expressed Circular Ribonucleic Acids and Methylation-Related Function in Pheochromocytomas and Paragangliomas.	hsa_circ_0007444				pheochromocytomas and paragangliomas 	MONDO:0017366	hereditary pheochromocytoma-paraganglioma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0007444 is down-regulated in PCC/PGL tumor tissues compared with adjacent tissues and was validated by RT-qPCR among top candidates. No additional functional or mechanistic details are provided in the text.	0.3588
32164722	Molecular cancer	2020	CircMRPS35 suppresses gastric cancer progression via recruiting KAT7 to govern histone modification.	hsa_circ_0000384		hsa_circ_MRPS35	MRPS35	gastric cancer	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; ISH; RNA-seq	"circMRPS35 (hsa_circ_0000384) is down-regulated in gastric cancer and functions as a tumor suppressor. It localizes mainly in the nucleus and scaffolds KAT7 to FOXO1/FOXO3a promoters to increase H4K5 acetylation, thereby transcriptionally activating FOXO1/FOXO3a and downstream genes (p21/p27, Twist1, E-cadherin) to inhibit proliferation, cell-cycle progression, invasion and metastasis. Low circMRPS35 expression is associated with worse patient survival."	0.9043
32165864	Cancer cell international	2020	"Circ_0032821 acts as an oncogene in cell proliferation, metastasis and autophagy in human gastric cancer cells in vitro and in vivo through activating MEK1/ERK1/2 signaling pathway."	hsa_circ_0032821		hsa_circ_CEP128	CEP128	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"circ_0032821 is up-regulated in gastric cancer tissues and cell lines and correlates with advanced TNM stage, lymph node metastasis, and worse overall survival. Functionally, it promotes proliferation, EMT, migration/invasion and tumor growth while inhibiting autophagy, at least partly by activating the MEK1/ERK1/2 pathway."	0.6516
32166857	Journal of cellular and molecular medicine	2020	"Effect of up-regulation of circMATR3 on the proliferation, metastasis, progression and survival of hypopharyngeal carcinoma."	hsa_circ_0008922		hsa_circ_MATR3	MATR3	hypopharyngeal squamous cell carcinoma 	MONDO:0044638	hypopharynx squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circMATR3 is up-regulated in HSCC tissues and mainly localizes to the cytoplasm. Functional knockdown in FaDu cells suppresses proliferation, migration and invasion and increases apoptosis; high tumor expression correlates with advanced clinicopathological features and poor survival, with a predicted ceRNA (miRNA sponge) mechanism affecting pathways such as MAPK and mTOR."	0.8008
32167655	Cancer medicine	2020	Circ-PGAM1 promotes malignant progression of epithelial ovarian cancer through regulation of the miR-542-3p/CDC5L/PEAK1 pathway.	hsa_circ_0019340		hsa_circ_PGAM1	PGAM1	epithelial ovarian cancer 	MONDO:0005140	ovarian carcinoma	up-regulated	RT-qPCR	"Circ-PGAM1 is up-regulated in epithelial ovarian cancer and acts as an oncogenic circRNA. It sponges miR-542-3p (mutual negative feedback), leading to increased CDC5L and downstream PEAK1 transcription, which promotes malignant phenotypes and is associated with activation of ERK1/2 and JAK2 signaling."	0.7631
32181485	Bioscience reports	2020	CircRNA_0058063 functions as a ceRNA in bladder cancer progression via targeting miR-486-3p/FOXP4 axis.	hsa_circ_0058063		hsa_circ_ATIC	ATIC	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"circRNA_0058063 is up-regulated in bladder cancer and its high expression is associated with worse overall survival and more advanced disease. Functionally, circRNA_0058063 promotes proliferation and invasion and inhibits apoptosis in BC cells by acting as a ceRNA that sponges miR-486-3p to upregulate FOXP4."	0.7845
32181994	Thoracic cancer	2020	Circ_0038467 regulates lipopolysaccharide-induced inflammatory injury in human bronchial epithelial cells through sponging miR-338-3p.	hsa_circ_0038467		hsa_circ_UQCRC2	UQCRC2	pneumonia 	MONDO:0005249	pneumonia	up-regulated	RT-qPCR	circ_0038467 is up-regulated in LPS-treated human bronchial epithelial (16HBE) cells and promotes inflammatory injury. Its knockdown reduces apoptosis and inflammatory cytokine production and improves cell viability by sponging miR-338-3p and suppressing JAK/STAT3 pathway activation.	0.7204
32182212	Aging	2020	Comprehensive analysis of circular RNA profiles in skeletal muscles of aging mice and after aerobic exercise intervention.		circBBS9	mmu_circ_BBS9	BBS9	aging-associated muscle dysfunction 			down-regulated	RT-qPCR; RNA-seq	"circBBS9 is down-regulated in aged mouse quadriceps muscle and its level is restored by aerobic exercise. The study builds a predicted circBBS9_miRNA_mRNA network and shows that circBBS9 overexpression in C2C12 myotubes increases several predicted target mRNAs and shifts muscle gene programs toward improved mitochondrial function and reduced atrophy, suggesting circBBS9 may mediate benefits of aerobic training during muscle aging."	0.6926
32183822	World journal of surgical oncology	2020	"Circ-FOXM1 contributes to cell proliferation, invasion, and glycolysis and represses apoptosis in melanoma by regulating miR-143-3p/FLOT2 axis."	hsa_circ_0025039		hsa_circ_FOXM1	FOXM1	melanoma 	MONDO:0005105	melanoma	up-regulated	RT-qPCR	"Circ-FOXM1 is up-regulated in melanoma tissues/cells and functions as an oncogenic circRNA. It sponges miR-143-3p to de-repress FLOT2, thereby promoting proliferation, invasion and glycolysis while inhibiting apoptosis, and it enhances tumor growth in a xenograft model."	0.6825
32184614	OncoTargets and therapy	2020	Hsa_circ_103973 Acts as a Sponge of miR-335 to Promote Cervical Cancer Progression.		hsa_circ_103973			Cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"circ_103973 is up-regulated in cervical cancer tissues and cell lines and is associated with worse patient prognosis. Functionally, circ_103973 promotes proliferation and cell-cycle progression and suppresses apoptosis in vitro. Mechanistically, it acts as a ceRNA by sponging miR-335 to increase PPP6C expression (circ_103973/miR-335/PPP6C axis)."	0.7745
32184627	OncoTargets and therapy	2020	Circular RNA hsa_circ_0068033 Acts as a Diagnostic Biomarker and Suppresses the Progression of Breast Cancer Through Sponging miR-659.	hsa_circ_0068033				breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; ISH	"hsa_circ_0068033 is down-regulated in breast cancer and functions as a tumor suppressor. Its overexpression inhibits proliferation/colony formation, migration and invasion, reduces xenograft tumorigenicity, and promotes intrinsic apoptosis, at least partly by sponging miR-659, supporting diagnostic utility (AUC=0.8480)."	0.8126
32185826	Journal of clinical laboratory analysis	2020	Hsa_circ_0012563 promotes migration and invasion of esophageal squamous cell carcinoma by regulating XRCC1/EMT pathway.	hsa_circ_0012563		hsa_circ_ZYG11A	ZYG11A	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"hsa_circ_0012563 is up-regulated in ESCC tissues and cell lines and acts as an oncogenic circRNA. Its knockdown inhibits proliferation, migration, and invasion while promoting apoptosis, at least partly by modulating the XRCC1/EMT pathway."	0.6218
32187743	Journal of clinical laboratory analysis	2020	"Circular RNA La-related RNA-binding protein 4 correlates with reduced tumor stage, as well as better prognosis, and promotes chemosensitivity to doxorubicin in breast cancer."			hsa_circ_LARP4	LARP4	breast cancer	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	circ-LARP4 is down-regulated in breast cancer tumor tissues and breast cancer cell lines compared with controls. Higher tumor circ-LARP4 levels are associated with earlier stage and better DFS/OS. Overexpression of circ-LARP4 increases doxorubicin sensitivity in MCF-7 and MDA-MB-231 cells.	0.6866
32187976	Cancers	2020	Oxaliplatin-Induced DHX9 Phosphorylation Promotes Oncogenic Circular RNA CCDC66 Expression and Development of Chemoresistance.			hsa_circ_CCDC66	CCDC66	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"circCCDC66 is up-regulated in oxaliplatin-resistant colorectal cancer cells and is induced by oxaliplatin treatment. It promotes cell survival and chemoresistance by modulating a miRNA-associated gene network affecting apoptosis and cell-cycle related genes, and its induction depends on PI3KK-mediated DHX9 phosphorylation that enhances circRNA biogenesis."	0.5067
32188476	Virology journal	2020	Circular RNA hsa_circ_0004812 impairs IFN-induced immune response by sponging miR-1287-5p to regulate FSTL1 in chronic hepatitis B.	hsa_circ_0004812				chronic hepatitis B 	MONDO:0005366	chronic hepatitis B virus infection	up-regulated	RT-qPCR	"hsa_circ_0004812 is up-regulated in CHB patient blood and liver tissues and in HBV-infected hepatoma cells. It is mainly cytoplasmic and acts as a miR-1287-5p sponge to upregulate FSTL1, thereby impairing IFN-alpha/IFN-beta induction and promoting HBV-induced immune suppression."	0.6956
32188489	Molecular cancer	2020	CircLONP2 enhances colorectal carcinoma invasion and metastasis through modulating the maturation and exosomal dissemination of microRNA-17.	hsa_circ_0008558		hsa_circ_LONP2	LONP2	colorectal carcinoma 	MONDO:0024331	colorectal carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circLONP2 is up-regulated in metastatic/advanced CRC and promotes CRC invasion and metastasis. It binds pri-miR-17 and, via DDX1, recruits the DGCR8/Drosha microprocessor to enhance miR-17 maturation; increased miR-17-5p is packaged into exosomes and transferred to nearby CRC cells to disseminate metastatic potential. High circLONP2 expression associates with poor overall survival."	0.8934
32190002	Cancer cell international	2020	Circ_0072083 interference enhances growth-inhibiting effects of cisplatin in non-small-cell lung cancer cells via miR-545-3p/CBLL1 axis.	hsa_circ_0072083		hsa_circ_ZFR	ZFR	Non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0072083 (circZFR) is up-regulated in NSCLC tissues/cells and mainly localized in the cytoplasm. It promotes malignant behaviors and cisplatin resistance by sponging miR-545-3p, thereby increasing CBLL1 expression; circ_0072083 depletion enhances DDP-induced growth inhibition and apoptosis in vitro and reduces xenograft tumor growth in vivo."	0.7635
32190004	Cancer cell international	2020	Circular RNA circPITX1 knockdown inhibits glycolysis to enhance radiosensitivity of glioma cells by miR-329-3p/NEK2 axis.			hsa_circ_PITX1	PITX1	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circPITX1 is up-regulated in glioma tissues/cells and promotes glycolysis and radioresistance. Mechanistically, circPITX1 sponges miR-329-3p to increase NEK2 expression, enhancing glycolysis-associated protein expression and clonogenic survival; circPITX1 knockdown inhibits tumor growth in xenografts and increases radiosensitivity."	0.7164
32190005	Cancer cell international	2020	CircPIP5K1A facilitates gastric cancer progression via miR-376c-3p/ZNF146 axis.	hsa_circ_0014130		hsa_circ_PIP5K1A	PIP5K1A	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circPIP5K1A is up-regulated in gastric cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes GC proliferation, migration/invasion and tumor growth while inhibiting apoptosis, acting as a ceRNA that sponges miR-376c-3p to increase ZNF146 expression; high expression is associated with adverse clinicopathological features and poorer survival."	0.873
32190008	Cancer cell international	2020	Circ_0008035 contributes to cell proliferation and inhibits apoptosis and ferroptosis in gastric cancer via miR-599/EIF4A1 axis.	hsa_circ_0008035				gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_0008035 is up-regulated in gastric cancer tissues/cells and mainly localized in the cytoplasm. It promotes GC cell proliferation and tumor growth while inhibiting apoptosis and ferroptosis by sponging miR-599 to increase EIF4A1 expression, and high circ_0008035 is associated with worse overall survival."	0.7357
32191279	Bioscience reports	2020	RNA-seq reveals the circular RNA and miRNA expression profile of peripheral blood mononuclear cells in patients with rheumatoid arthritis.	hsa_circ_0001200		hsa_circ_PTTG1IP	PTTG1IP	rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001200 is significantly up-regulated in PBMCs from RA patients (validated by RT-qPCR). Its expression correlates with clinical measurements (silk time and CCP), suggesting potential diagnostic biomarker relevance and involvement in RA pathogenesis."	0.5135
32191279	Bioscience reports	2020	RNA-seq reveals the circular RNA and miRNA expression profile of peripheral blood mononuclear cells in patients with rheumatoid arthritis.	hsa_circ_0001566		hsa_circ_MAPK9	MAPK9	rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001566 is up-regulated in PBMCs from RA patients (RT-qPCR validated). Its level correlates positively with CCP and negatively with IGA, supporting its potential as an RA biomarker."	0.5135
32191279	Bioscience reports	2020	RNA-seq reveals the circular RNA and miRNA expression profile of peripheral blood mononuclear cells in patients with rheumatoid arthritis.	hsa_circ_0003972		hsa_circ_FAM120A	FAM120A	rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0003972 is up-regulated in PBMCs from RA patients (RT-qPCR validated). Higher levels are positively associated with RA disease activity (DAS28) and joint tenderness, indicating potential utility as an activity-related biomarker."	0.5135
32191279	Bioscience reports	2020	RNA-seq reveals the circular RNA and miRNA expression profile of peripheral blood mononuclear cells in patients with rheumatoid arthritis.	hsa_circ_0008360		hsa_circ_XPNPEP3	XPNPEP3	rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0008360 is down-regulated in PBMCs from RA patients (RT-qPCR validated). Lower levels are negatively associated with silk time and CCP, supporting its potential biomarker relevance in RA."	0.5135
32193152	Molecular therapy. Nucleic acids	2020	hsa_circ_001653 Implicates in the Development of Pancreatic Ductal Adenocarcinoma by Regulating MicroRNA-377-Mediated HOXC6 Axis.		hsa_circ_001653			Pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; ISH; Microarray	"hsa_circ_001653 is up-regulated in PDAC tissues/cell lines and its high expression correlates with worse overall survival. Functionally, it promotes proliferation/cell-cycle progression, invasion, angiogenesis and xenograft growth while inhibiting apoptosis, mainly by binding miR-377 and increasing HOXC6 expression (ceRNA axis)."	0.8074
32193155	Molecular therapy. Nucleic acids	2020	circRNA-AKT1 Sequesters miR-942-5p to Upregulate AKT1 and Promote Cervical Cancer Progression.	hsa_circ_0033550		hsa_circ_AKT1	AKT1	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"circ-AKT1 (circ-0033550) is up-regulated in cervical cancer tissues, serum, and CC cell lines, mainly localized in the cytoplasm. It promotes proliferation, invasion, EMT, and xenograft tumor growth by sponging miR-942-5p to upregulate AKT1, forming the circ-AKT1/miR-942-5p/AKT1 axis; TGF-beta induces circ-AKT1 and AKT1 expression."	0.8781
32194644	Frontiers in genetics	2020	circGNB1 Facilitates Triple-Negative Breast Cancer Progression by Regulating miR-141-5p-IGF1R Axis.	hsa_circ_0009362	circGNB1	hsa_circ_GNB1	GNB1	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; Microarray	"circGNB1 (hsa_circ_0009362), derived from GNB1, is up-regulated in TNBC and mainly localized in the cytoplasm. It promotes TNBC proliferation, migration and in vivo tumor growth/metastasis by sponging miR-141-5p and relieving repression of IGF1R (circGNB1/miR-141-5p/IGF1R ceRNA axis). High circGNB1 expression associates with worse clinicopathologic features and poor OS/DFS, serving as an independent prognostic risk factor."	0.8557
32194715	Oncology letters	2020	Integrated analysis of circular RNA-associated ceRNA network in pancreatic ductal adenocarcinoma.	hsa_circ_0006220		hsa_circ_TADA2A	TADA2A	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	Microarray	"hsa_circ_0006220 is up-regulated in PDAC microarray datasets and was included in a predicted circRNA-miRNA-mRNA ceRNA network. The study suggests it may contribute to PDAC progression, but provides no experimental validation beyond bioinformatics/microarray analyses."	0.1768
32194715	Oncology letters	2020	Integrated analysis of circular RNA-associated ceRNA network in pancreatic ductal adenocarcinoma.	hsa_circ_0043278		hsa_circ_TADA2A	TADA2A	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	Microarray	"hsa_circ_0043278 is up-regulated in PDAC microarray datasets and was included in a predicted circRNA-miRNA-mRNA ceRNA network. The study suggests it may contribute to PDAC progression, but provides no experimental validation beyond bioinformatics/microarray analyses."	0.1768
32194715	Oncology letters	2020	Integrated analysis of circular RNA-associated ceRNA network in pancreatic ductal adenocarcinoma.	hsa_circ_0001666		hsa_circ_FAM120B	FAM120B	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	Microarray	"hsa_circ_0001666 is up-regulated in PDAC microarray datasets and was included in a predicted circRNA-miRNA-mRNA ceRNA network. The study suggests it may contribute to PDAC progression, but provides no experimental validation beyond bioinformatics/microarray analyses."	0.1768
32194715	Oncology letters	2020	Integrated analysis of circular RNA-associated ceRNA network in pancreatic ductal adenocarcinoma.	hsa_circ_0092367				pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	down-regulated	Microarray	"hsa_circ_0092367 is down-regulated in PDAC microarray datasets and was included in the predicted ceRNA network, but its hubgene submodule with miR-375/TGFB2 was excluded due to inconsistent expression patterns. No experimental validation was performed."	0.1768
32194801	Journal of Cancer	2020	Circular RNA CircHIPK3 Promotes Gemcitabine Sensitivity in Bladder Cancer.	hsa_circ_0000284		hsa_circ_HIPK3	HIPK3	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; Microarray	"CircHIPK3 is down-regulated in bladder cancer tissues and cell lines and its low expression is associated with gemcitabine insensitivity. Overexpression of circHIPK3 re-sensitizes gemcitabine-resistant BC cells by lowering gemcitabine IC50, reducing viability, and increasing apoptosis, while the mechanism is not experimentally established in this work."	0.7036
32194869	Theranostics	2020	Circular RNA-ZBTB44 regulates the development of choroidal neovascularization.			mmu_circ_ZBTB44	ZBTB44	choroidal neovascularization 	MONDO:0810000	choroidal neovascularization	up-regulated	RT-qPCR	"cZBTB44 is up-regulated during CNV and in hypoxia-stressed endothelial cells, and it promotes angiogenic phenotypes and CNV formation. Mechanistically, it functions as a ceRNA by sponging miR-578, thereby relieving repression of VEGFA and VCAM1. cZBTB44 is also elevated in aqueous humor from nAMD patients, suggesting potential translational relevance."	0.7799
32194869	Theranostics	2020	Circular RNA-ZBTB44 regulates the development of choroidal neovascularization.	hsa_circ_0002484		hsa_circ_ZBTB44	ZBTB44	choroidal neovascularization 	MONDO:0810000	choroidal neovascularization	up-regulated	RT-qPCR	"cZBTB44 is up-regulated during CNV and in hypoxia-stressed endothelial cells, and it promotes angiogenic phenotypes and CNV formation. Mechanistically, it functions as a ceRNA by sponging miR-578, thereby relieving repression of VEGFA and VCAM1. cZBTB44 is also elevated in aqueous humor from nAMD patients, suggesting potential translational relevance."	0.7799
32207384	Technology in cancer research & treatment	2020	Circular RNA circMTO1 Suppresses RCC Cancer Cell Progression via miR9/LMX1A Axis.	hsa_circ_0007874	hsa_circRNA_104135	hsa_circ_MTO1	MTO1	renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	unknown	RT-qPCR	"In RCC cell lines, circMTO1 functions as a tumor-suppressive circRNA that inhibits proliferation, migration and invasion. Mechanistically, circMTO1 sponges miR9 (and potentially miR223), thereby protecting the miR9 target LMX1A and restraining RCC progression."	0.4611
32210583	OncoTargets and therapy	2020	Up-Regulation of Hsa_circ_0008792 Inhibits Osteosarcoma Cell Invasion and Migration and Promotes Apoptosis by Regulating Hsa-miR-711/ZFP1.	hsa_circ_0008792				osteosarcoma	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0008792 is down-regulated in osteosarcoma cell lines. Its up-regulation suppresses migration, invasion, and proliferation and promotes apoptosis by sponging hsa-miR-711 to increase ZFP1 expression, forming the hsa_circ_0008792/hsa-miR-711/ZFP1 axis."	0.6004
32210630	Cancer management and research	2020	hsa_circRNA_012515 Is Highly Expressed in NSCLC Patients and Affects Its Prognosis.	hsa_circ_0001255	hsa_circRNA_012515	hsa_circ_PANX2	PANX2	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_012515 (host gene PANX2) is significantly up-regulated in NSCLC tissues, NSCLC cell lines, and gefitinib-resistant samples. High expression shows diagnostic value (ROC AUC 0.89) and is associated with advanced stage/lymph node metastasis and worse survival outcomes. Its mechanism was explored by bioinformatic prediction suggesting interaction with five miRNAs, but downstream targets were not experimentally validated."	0.636
32211036	Frontiers in genetics	2020	Circular RNA-Expression Profiling Reveals a Potential Role of Hsa_circ_0097435 in Heart Failure via Sponging Multiple MicroRNAs.	hsa_circ_0097435				heart failure 	MONDO:0005252	heart failure	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0097435 is up-regulated in peripheral blood and plasma exosomes of heart failure patients. In AC16 cardiomyocytes, it increases after doxorubicin-induced injury and promotes apoptosis, likely by acting as a miRNA sponge (including miR-6799-5P, miR-5000-5P, miR-609, miR-1294, miR-96-5P) through an AGO2-associated mechanism. The authors propose it as a blood biomarker for heart failure."	0.8191
32211036	Frontiers in genetics	2020	Circular RNA-Expression Profiling Reveals a Potential Role of Hsa_circ_0097435 in Heart Failure via Sponging Multiple MicroRNAs.	hsa_circ_0099476				heart failure 	MONDO:0005252	heart failure	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0099476 was identified as significantly up-regulated in peripheral blood from heart failure patients compared with controls, supported by RNA-seq screening and RT-qPCR validation. No additional functional mechanism was reported for this circRNA in the study."	0.3588
32211036	Frontiers in genetics	2020	Circular RNA-Expression Profiling Reveals a Potential Role of Hsa_circ_0097435 in Heart Failure via Sponging Multiple MicroRNAs.	hsa_circ_0001312				heart failure 	MONDO:0005252	heart failure	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0001312 was validated as significantly up-regulated in peripheral blood from heart failure patients versus controls (RNA-seq screening with RT-qPCR validation). The study did not further characterize its function or mechanism.	0.3588
32211036	Frontiers in genetics	2020	Circular RNA-Expression Profiling Reveals a Potential Role of Hsa_circ_0097435 in Heart Failure via Sponging Multiple MicroRNAs.	hsa_circ_0005158				heart failure 	MONDO:0005252	heart failure	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0005158 was significantly up-regulated in peripheral blood of heart failure patients compared with controls and was among the circRNAs validated by RT-qPCR. No functional or mechanistic experiments were reported for this circRNA.	0.3588
32211036	Frontiers in genetics	2020	Circular RNA-Expression Profiling Reveals a Potential Role of Hsa_circ_0097435 in Heart Failure via Sponging Multiple MicroRNAs.	hsa_circ_0029696				heart failure 	MONDO:0005252	heart failure	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0029696 was significantly up-regulated in peripheral blood from heart failure patients and was validated by RT-qPCR. The paper did not report downstream mechanisms or functions for this circRNA.	0.3588
32211036	Frontiers in genetics	2020	Circular RNA-Expression Profiling Reveals a Potential Role of Hsa_circ_0097435 in Heart Failure via Sponging Multiple MicroRNAs.	hsa_circ_0040414				heart failure 	MONDO:0005252	heart failure	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0040414 was among six circRNAs confirmed by RT-qPCR to be significantly up-regulated in peripheral blood of heart failure patients versus controls. No further functional characterization was provided for this circRNA.	0.3588
32212290	Journal of clinical laboratory analysis	2020	Hsa_circ_0001649 restrains gastric carcinoma growth and metastasis by downregulation of miR-20a.	hsa_circ_0001649				Gastric carcinoma 	MONDO:0004950	gastric carcinoma	down-regulated	RT-qPCR	"hsa_circ_0001649 is down-regulated in gastric carcinoma tissues and cell lines. Its overexpression suppresses GC cell growth and metastatic behaviors and promotes apoptosis, at least partly by downregulating miR-20a and inhibiting ERK and Wnt/beta-catenin signaling."	0.5434
32213200	Molecular cancer	2020	Autophagy-associated circRNA circCDYL augments autophagy and promotes breast cancer progression.	hsa_circ_0008285		hsa_circ_CDYL	CDYL	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circCDYL (hsa_circ_0008285) is up-regulated in breast cancer tissues and serum, and high expression is associated with worse patient outcomes. It promotes breast cancer progression by acting as a miR-1275 sponge to upregulate ATG7 and ULK1, enhancing autophagic flux and proliferation."	0.8547
32218863	Oncology letters	2020	Integrated analysis of transcriptome profiling predicts potential lncRNA and circRNA targets in human nasopharyngeal carcinoma.		hsa_circRNA_104204			nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_104204 is up-regulated in NPC tissue and was validated by RT-qPCR. The study predicts it participates in a circRNA_miRNA_mRNA network by binding miRNAs (e.g., hsa-miR-448/hsa-miR-18a/b-5p) and associating with downstream mRNAs such as BTG3, NTF3, SPRY2 and TBX3."	0.5135
32218863	Oncology letters	2020	Integrated analysis of transcriptome profiling predicts potential lncRNA and circRNA targets in human nasopharyngeal carcinoma.		hsa_circRNA_101252			nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circRNA_101252 is up-regulated in NPC tissue and was validated by RT-qPCR. It was placed into a predicted ceRNA network where it may bind hsa-miR-145-5p and associate with mRNAs including ITGB8 and MPZL1.	0.5135
32218863	Oncology letters	2020	Integrated analysis of transcriptome profiling predicts potential lncRNA and circRNA targets in human nasopharyngeal carcinoma.		hsa_circRNA_100160			nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circRNA_100160 is markedly up-regulated in NPC tissue and was validated by RT-qPCR. It was incorporated into a predicted ceRNA module where it may bind hsa-miR-518a-5p and associate with JAKMIP1 and RAPGEF5.	0.5135
32218863	Oncology letters	2020	Integrated analysis of transcriptome profiling predicts potential lncRNA and circRNA targets in human nasopharyngeal carcinoma.		hsa_circRNA_001430			nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	down-regulated	RT-qPCR; Microarray	hsa_circRNA_001430 is down-regulated in NPC tissue and was validated by RT-qPCR. It was included in a predicted ceRNA network where it may bind hsa-miR-16-5p and associate with mRNAs such as C18orf34 and SH3GL2.	0.5135
32221048	Aging	2020	Whole-transcriptome analysis reveals a potential hsa_circ_0001955/hsa_circ_0000977-mediated miRNA-mRNA regulatory sub-network in colorectal cancer.	hsa_circ_0001955	hsa_circRNA_101555	hsa_circ_CSNK1G1	CSNK1G1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001955 is up-regulated in colorectal cancer tissues and is proposed to function as a ceRNA by sponging miR-145-5p. The study links this axis to positively correlated downstream targets (CDK6, MMP12, RAB3IP) based on in silico network analyses and RT-qPCR validation in clinical samples."	0.4032
32221048	Aging	2020	Whole-transcriptome analysis reveals a potential hsa_circ_0001955/hsa_circ_0000977-mediated miRNA-mRNA regulatory sub-network in colorectal cancer.	hsa_circ_0000977	hsa_circRNA_102619	hsa_circ_NOL10	NOL10	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0000977 is down-regulated in colorectal cancer tissues and is proposed to act in a ceRNA network, with a key statistically significant axis hsa_circ_0000977/miR-135b-5p. The study connects this axis to positively correlated downstream targets (FOXO1, MBNL1, MEF2C, RECK, PPM1E, TTLL7, PCP4L1) based on in silico analyses and RT-qPCR validation in clinical samples."	0.4032
32222024	Journal of cellular and molecular medicine	2020	Circular RNA circFBXO11 modulates hepatocellular carcinoma progress and oxaliplatin resistance through miR-605/FOXO3/ABCB1 axis.	hsa_circ_0001001		hsa_circ_FBXO11	FBXO11	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circFBXO11 (hsa_circ_0001001), derived from FBXO11, is up-regulated in HCC and associated with poor prognosis. It promotes proliferation, cell-cycle progression, tumor growth, and oxaliplatin resistance by sponging miR-605 to enhance FOXO3, which transcriptionally activates ABCB1."	0.8632
32223537	Emerging microbes & infections	2020	Competing endogenous RNA network profiling reveals novel host dependency factors required for MERS-CoV propagation.	hsa_circ_0067985		hsa_circ_FNDC3B	FNDC3B	Middle East respiratory syndrome coronavirus 	MONDO:0100116	Middle East respiratory syndrome	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0067985 (circFNDC3B), derived from FNDC3B, is up-regulated upon MERS-CoV infection and functions as a predicted ceRNA/miRNA sponge with Ago2 binding sites. Its knockdown decreases representative target mRNAs (e.g., MAP3K9, MYO15B, SPOCK1) and suppresses MERS-CoV replication, while overexpression enhances viral replication."	0.5761
32223537	Emerging microbes & infections	2020	Competing endogenous RNA network profiling reveals novel host dependency factors required for MERS-CoV propagation.	hsa_circ_0006275		hsa_circ_CNOT1	CNOT1	Middle East respiratory syndrome coronavirus 	MONDO:0100116	Middle East respiratory syndrome	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0006275 (circCNOT1), derived from CNOT1, is up-regulated upon MERS-CoV infection and is proposed to act as a ceRNA/miRNA sponge with predicted Ago2 binding sites. Its depletion reduces representative target mRNAs (e.g., MAP3K9, MEF2C, USP15, ZBTB11) and suppresses MERS-CoV replication, while overexpression enhances viral replication."	0.5761
32226441	Frontiers in genetics	2020	CircRNA Expression Profiles and the Potential Role of CircZFP644 in Mice With Severe Acute Pancreatitis via Sponging miR-21-3p.		CircAMY2a5	mmu_circ_AMY2a5		severe acute pancreatitis 	MONDO:0006515	acute pancreatitis	down-regulated	RT-qPCR; RNA-seq	CircAMY2a5 is significantly down-regulated in pancreatic tissues from the SAP mouse model versus controls and was among six circRNAs validated by qRT-PCR after RNA-seq profiling.	0.4625
32226441	Frontiers in genetics	2020	CircRNA Expression Profiles and the Potential Role of CircZFP644 in Mice With Severe Acute Pancreatitis via Sponging miR-21-3p.	mmu_circ_0001382		mmu_circ_ZFP644	ZFP644	severe acute pancreatitis 	MONDO:0006515	acute pancreatitis	down-regulated	RT-qPCR; RNA-seq	"CircZFP644 (mmu_circ_0000663/mmu_circ_0001382), derived from the ZFP644 host gene, is significantly down-regulated in pancreatic tissues of SAP mice. The study characterizes its circularity (back-splice junction, RNase R resistance) and supports a potential ceRNA mechanism where CircZFP644 sponges miR-21-3p (negative correlation and predicted binding sites) to influence SAP pathophysiology."	0.6926
32226441	Frontiers in genetics	2020	CircRNA Expression Profiles and the Potential Role of CircZFP644 in Mice With Severe Acute Pancreatitis via Sponging miR-21-3p.	mmu_circ_0000663		mmu_circ_ZFP644	ZFP644	severe acute pancreatitis 	MONDO:0006515	acute pancreatitis	down-regulated	RT-qPCR; RNA-seq	"CircZFP644 (mmu_circ_0000663/mmu_circ_0001382), derived from the ZFP644 host gene, is significantly down-regulated in pancreatic tissues of SAP mice. The study characterizes its circularity (back-splice junction, RNase R resistance) and supports a potential ceRNA mechanism where CircZFP644 sponges miR-21-3p (negative correlation and predicted binding sites) to influence SAP pathophysiology."	0.6926
32226441	Frontiers in genetics	2020	CircRNA Expression Profiles and the Potential Role of CircZFP644 in Mice With Severe Acute Pancreatitis via Sponging miR-21-3p.	mmu_circ_0000349	CircDTNB	mmu_circ_DTNB		severe acute pancreatitis 	MONDO:0006515	acute pancreatitis	down-regulated	RT-qPCR; RNA-seq	CircDTNB (mmu_circ_0000349) is significantly down-regulated in pancreatic tissues from SAP mice and was validated by qRT-PCR consistent with RNA-seq.	0.4625
32226441	Frontiers in genetics	2020	CircRNA Expression Profiles and the Potential Role of CircZFP644 in Mice With Severe Acute Pancreatitis via Sponging miR-21-3p.		CircCELA3b	mmu_circ_CELA3b		severe acute pancreatitis 	MONDO:0006515	acute pancreatitis	down-regulated	RT-qPCR; RNA-seq	CircCELA3b is significantly down-regulated in pancreatic tissues from SAP mice and was validated by qRT-PCR consistent with RNA-seq.	0.4625
32226441	Frontiers in genetics	2020	CircRNA Expression Profiles and the Potential Role of CircZFP644 in Mice With Severe Acute Pancreatitis via Sponging miR-21-3p.		CircARHGEF38	mmu_circ_ARHGEF38		severe acute pancreatitis 	MONDO:0006515	acute pancreatitis	down-regulated	RT-qPCR; RNA-seq	CircARHGEF38 is significantly down-regulated in pancreatic tissues from SAP mice and was validated by qRT-PCR consistent with RNA-seq.	0.4625
32226441	Frontiers in genetics	2020	CircRNA Expression Profiles and the Potential Role of CircZFP644 in Mice With Severe Acute Pancreatitis via Sponging miR-21-3p.	mmu_circ_0001325	CircSRPK2	mmu_circ_SRPK2		severe acute pancreatitis 	MONDO:0006515	acute pancreatitis	down-regulated	RT-qPCR; RNA-seq	CircSRPK2 (mmu_circ_0001325) is significantly down-regulated in pancreatic tissues from SAP mice and was validated by qRT-PCR consistent with RNA-seq.	0.4625
32226494	Journal of Cancer	2020	Circular RNA CCDC66 promotes gastric cancer progression by regulating c-Myc and TGF-beta signaling pathways.			hsa_circ_CCDC66	CCDC66	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circCCDC66 is up-regulated in gastric cancer tissues and cell lines and is associated with higher tumor stage and lymphatic metastasis. Functionally, it promotes GC cell proliferation, migration, invasion and tumor growth while inhibiting apoptosis. Mechanistically, it activates c-Myc and TGF-beta/SMAD signaling and promotes EMT."	0.622
32226514	Journal of Cancer	2020	Global transcriptomic study of circRNAs expression profile in sorafenib resistant hepatocellular carcinoma cells.	hsa_circ_0006294				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0006294 is significantly down-regulated in sorafenib-resistant HCC cell lines (Huh7-S and HepG2-S) and is suggested to be involved in sorafenib chemoresistance, though its specific targets and mechanisms were not identified in this study."	0.1904
32226514	Journal of Cancer	2020	Global transcriptomic study of circRNAs expression profile in sorafenib resistant hepatocellular carcinoma cells.	hsa_circ_0035944				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0035944 is significantly down-regulated in sorafenib-resistant HCC cell lines (Huh7-S and HepG2-S) and is suggested to be related to sorafenib chemoresistance, but its downstream targets/mechanisms were not determined in this work."	0.1904
32226514	Journal of Cancer	2020	Global transcriptomic study of circRNAs expression profile in sorafenib resistant hepatocellular carcinoma cells.	hsa_circ_0084663				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0084663 is significantly down-regulated in sorafenib-resistant HCC cell lines (Huh7-S and HepG2-S) and is suggested to be associated with sorafenib chemoresistance, but no direct mechanistic axis was defined."	0.1904
32228656	Journal of experimental & clinical cancer research : CR	2020	circFOXM1 promotes proliferation of non-small cell lung carcinoma cells by acting as a ceRNA to upregulate FAM83D.	hsa_circ_0025039		hsa_circ_FOXM1	FOXM1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circFOXM1 is up-regulated in NSCLC and promotes proliferation/cell-cycle progression and xenograft tumor growth. It mainly localizes in the cytoplasm and functions as a ceRNA by sponging miR-614, thereby de-repressing FAM83D and increasing downstream cell-cycle proteins (e.g., CCND1, CCNE1). High circFOXM1 expression is associated with advanced stage and poor overall survival."	0.8662
32231737	Journal of Cancer	2020	Circular RNA MAN2B2 promotes cell proliferation of hepatocellular carcinoma cells via the miRNA-217/MAPK1 axis.	hsa_circ_0069085		hsa_circ_MAN2B2	MAM2B2	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circMAN2B2 is up-regulated in HCC tissues and promotes HCC cell proliferation. Mechanistically, it functions as a ceRNA that sponges miR-217, thereby increasing MAPK1 expression; MAPK1 overexpression rescues the proliferation inhibition caused by circMAN2B2 knockdown."	0.6369
32231744	Journal of Cancer	2020	miR-488-3p sponged by circ-0000495 and mediated upregulation of TROP2 in head and neck squamous cell carcinoma development.	hsa_circ_0000495		hsa_circ_MYCBP2	MYCBP2	head and neck squamous cell carcinoma 	MONDO:0010150	head and neck squamous cell carcinoma	up-regulated	RT-qPCR	"circ-0000495 is up-regulated in HNSCC cell lines and directly binds (sponges) miR-488-3p, thereby relieving repression of TROP2. This circ-0000495/miR-488-3p/TROP2 ceRNA axis contributes to tumor progression-related phenotypes."	0.5415
32232013	Frontiers in cellular and infection microbiology	2020	RNA-Seq Revealed a Circular RNA-microRNA-mRNA Regulatory Network in Hantaan Virus Infection.	hsa_circ_0000479				Hantaan virus infection 	MONDO:0005780	hantavirus infectious disease	dysregulated	RT-qPCR; RNA-seq	"circ_0000479 is a differentially expressed circRNA in HTNV-infected HUVECs and acts as an inhibitor of viral replication. It functions as a ceRNA by sponging miR-149-5p, thereby relieving miR-149-5p-mediated repression of RIG-I and strengthening antiviral responses."	0.6578
32232013	Frontiers in cellular and infection microbiology	2020	RNA-Seq Revealed a Circular RNA-microRNA-mRNA Regulatory Network in Hantaan Virus Infection.	hsa_circ_0002470				Hantaan virus infection 	MONDO:0005780	hantavirus infectious disease	dysregulated	RT-qPCR; RNA-seq	circ_0002470 is differentially expressed in HTNV-infected HUVECs and was RT-qPCR-validated. It was implicated by ceRNA analysis as part of the putative circ_0002470_miR-3182_IFI44 regulatory axis during HTNV infection.	0.5466
32232013	Frontiers in cellular and infection microbiology	2020	RNA-Seq Revealed a Circular RNA-microRNA-mRNA Regulatory Network in Hantaan Virus Infection.	hsa_circ_0006132				Hantaan virus infection 	MONDO:0005780	hantavirus infectious disease	dysregulated	RT-qPCR; RNA-seq	circ_0006132 is differentially expressed in HTNV-infected HUVECs and was RT-qPCR-validated. It was implicated by ceRNA analysis as part of the putative circ_0006132_miR-1304-3p_OAS1 axis during HTNV infection.	0.5802
32232013	Frontiers in cellular and infection microbiology	2020	RNA-Seq Revealed a Circular RNA-microRNA-mRNA Regulatory Network in Hantaan Virus Infection.	hsa_circ_0007793				Hantaan virus infection 	MONDO:0005780	hantavirus infectious disease	dysregulated	RT-qPCR; RNA-seq	"circ_0007793 was identified as differentially expressed upon HTNV infection in HUVECs and was validated by RT-qPCR. It was included in circRNA knockdown experiments measuring HTNV NP by western blot, but its specific mechanistic axis was not defined in the provided text."	0.5489
32232013	Frontiers in cellular and infection microbiology	2020	RNA-Seq Revealed a Circular RNA-microRNA-mRNA Regulatory Network in Hantaan Virus Infection.	hsa_circ_0022228				Hantaan virus infection 	MONDO:0005780	hantavirus infectious disease	dysregulated	RT-qPCR; RNA-seq	circ_0022228 was identified as differentially expressed upon HTNV infection in HUVECs and its differential expression was validated by RT-qPCR. No specific functional mechanism or interaction axis for circ_0022228 was reported in the provided text.	0.385
32232013	Frontiers in cellular and infection microbiology	2020	RNA-Seq Revealed a Circular RNA-microRNA-mRNA Regulatory Network in Hantaan Virus Infection.	hsa_circ_0046034				Hantaan virus infection 	MONDO:0005780	hantavirus infectious disease	dysregulated	RT-qPCR; RNA-seq	"circ_0046034 is differentially expressed in HTNV-infected HUVECs and was RT-qPCR-validated. Network analysis suggested it may act as a ceRNA by sequestering miR-149-5p, potentially affecting antiviral mRNAs such as RIG-I, IL16 and MX2."	0.5802
32232013	Frontiers in cellular and infection microbiology	2020	RNA-Seq Revealed a Circular RNA-microRNA-mRNA Regulatory Network in Hantaan Virus Infection.	hsa_circ_0066996				Hantaan virus infection 	MONDO:0005780	hantavirus infectious disease	dysregulated	RT-qPCR; RNA-seq	circ_0066996 was identified as differentially expressed upon HTNV infection in HUVECs and its differential expression was validated by RT-qPCR. No specific functional mechanism or interaction axis for circ_0066996 was reported in the provided text.	0.385
32232013	Frontiers in cellular and infection microbiology	2020	RNA-Seq Revealed a Circular RNA-microRNA-mRNA Regulatory Network in Hantaan Virus Infection.	hsa_circ_0073948				Hantaan virus infection 	MONDO:0005780	hantavirus infectious disease	dysregulated	RT-qPCR; RNA-seq	circ_0073948 was identified as differentially expressed upon HTNV infection in HUVECs and its differential expression was validated by RT-qPCR. No specific functional mechanism or interaction axis for circ_0073948 was reported in the provided text.	0.385
32236577	International journal of molecular medicine	2020	"Circular RNA circ_ACACA regulates proliferation, migration and glycolysis in non_small_cell lung carcinoma via miR_1183 and PI3K/PKB pathway."	hsa_circ_0106705		hsa_circ_ACACA	ACACA	non-small cell lung carcinoma 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ-ACACA is up-regulated in NSCLC tissues and cell lines and is associated with advanced stage, metastasis, and poorer overall survival. Functionally, circ-ACACA promotes proliferation, migration and glycolysis and tumor growth by sponging miR-1183, leading to activation of the PI3K/PKB (AKT) pathway (with PTEN up and p-PI3K/p-PKB down upon circ-ACACA knockdown)."	0.848
32236616	International journal of molecular medicine	2020	EMT related circular RNA expression profiles identify circSCYL2 as a novel molecule in breast tumor metastasis.			hsa_circ_SCYL2	SCYL2	breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; RNA-seq	"circSCYL2 (from SCYL2 exon 2-4) is down-regulated in breast cancer tissues/cell lines and its overexpression suppresses EMT-associated migration and invasion in MCF-7 and MDA-MB-231 cells. Mechanistically, the study¡¯s network analysis suggests circSCYL2 may influence EMT via an OSR1/TGF-beta signaling axis, but the interactions were stated to require further experimental validation."	0.673
32241279	Molecular cancer	2020	A novel protein encoded by circFNDC3B inhibits tumor progression and EMT through regulating Snail in colon cancer.			hsa_circ_FNDC3B	FNDC3B	Colon cancer 	MONDO:0021063	malignant colon neoplasm	down-regulated	RT-qPCR	"circFNDC3B is down-regulated in colon cancer tissues and cell lines and functions as a tumor suppressor by inhibiting proliferation, invasion, and migration. Low circFNDC3B expression is associated with shorter overall survival, indicating prognostic relevance."	0.7996
32242002	Cell death & disease	2020	"The regulatory network among CircHIPK3, LncGAS5, and miR-495 promotes Th2 differentiation in allergic rhinitis."			hsa_circ_HIPK3	HIPK3	Allergic rhinitis 	MONDO:0011786	allergic rhinitis	up-regulated	RT-qPCR	"CircHIPK3 is up-regulated in AR nasal mucosa and promotes Th2 differentiation and AR inflammation. Mechanistically, it binds and suppresses miR-495, relieving repression on GATA-3 and increasing GATA-3 expression; intranasal knockdown reduces AR symptoms in mice."	0.7094
32243061	Journal of cellular and molecular medicine	2020	Hsa_circ_0079662 induces the resistance mechanism of the chemotherapy drug oxaliplatin through the TNF-alpha pathway in human colon cancer.	hsa_circ_0079662		hsa_circ_HOXA9	HOXA9	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"hsa_circ_0079662 is up-regulated in oxaliplatin-resistant CRC cell lines and promotes malignant phenotypes (growth, migration, invasion) and drug resistance. Mechanistically, it functions as a ceRNA sponging hsa-miR-324-5p to de-repress HOXA9, and is linked to increased inflammatory cytokines including TNF-alpha, supporting a TNF-alpha pathway-associated resistance mechanism."	0.6583
32248836	Journal of experimental & clinical cancer research : CR	2020	Circular RNA hsa_circ_0000326 acts as a miR-338-3p sponge to facilitate lung adenocarcinoma progression.	hsa_circ_0000326		hsa_circ_MALAT1	MALAT1	lung adenocarcinoma	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000326 is up-regulated in lung adenocarcinoma and is associated with more aggressive clinicopathologic features. It promotes proliferation and migration and inhibits apoptosis by sponging miR-338-3p to increase RAB14 expression, and its knockdown suppresses xenograft tumor growth."	0.7421
32249539	Journal of cellular and molecular medicine	2020	Circular RNA PVT1 promotes metastasis via regulating of miR-526b/FOXC2 signals in OS cells.			hsa_circ_PVT1	PVT1	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; ISH	"circPVT1 is up-regulated in osteosarcoma and its high expression is associated with metastasis-related clinicopathological features and poor survival. Mechanistically, circPVT1 promotes migration/invasion by sponging miR-526b, thereby increasing FOXC2 protein expression and driving FOXC2-mediated metastasis."	0.8544
32250047	Cancer medicine	2020	"Downregulated hsa_circ_0077837 and hsa_circ_0004826, facilitate bladder cancer progression and predict poor prognosis for bladder cancer patients."	hsa_circ_0077837		hsa_circ_EPB41L2	EPB41L2	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0077837 is significantly down-regulated in bladder cancer and acts as a tumor suppressor by inhibiting proliferation, migration, and invasion in BC cells when overexpressed. Low expression is associated with adverse clinicopathological features and poorer OS/RFS, with diagnostic potential by ROC analysis. Mechanistically, it is analyzed within a predicted circRNA-miRNA-mRNA (ceRNA) network without downstream experimental validation."	0.7617
32250047	Cancer medicine	2020	"Downregulated hsa_circ_0077837 and hsa_circ_0004826, facilitate bladder cancer progression and predict poor prognosis for bladder cancer patients."	hsa_circ_0004826		hsa_circ_UTRN	UTRN	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0004826 is significantly down-regulated in bladder cancer and functions as a tumor suppressor, as its overexpression inhibits proliferation, migration, and invasion of BC cells. Clinically, low expression is associated with aggressive features and poorer survival, and it shows diagnostic potential by ROC analysis. It is included in a bioinformatically predicted circRNA-miRNA-mRNA (ceRNA) network, but downstream targets were not validated experimentally."	0.7617
32256118	Cancer management and research	2020	hsa_circRNA_101237: A Novel Diagnostic and Prognostic Biomarker and Potential Therapeutic Target for Multiple Myeloma.	hsa_circ_0003489	hsa_circRNA_101237	hsa_circ_CDK8	CDK8	multiple myeloma 	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_101237 (hsa_circ_0003489; host gene CDK8) is significantly up-regulated in multiple myeloma bone marrow samples and MM cell lines, especially bortezomib-resistant cells. High hsa_circRNA_101237 is linked to worse prognosis (shorter OS/PFS) and poorer response to bortezomib, and bioinformatics suggests a potential circRNA_miRNA_mRNA regulatory network involving pathways such as PI3K-Akt and cell cycle."	0.636
32256212	Cancer cell international	2020	Circular RNA circVAPA knockdown suppresses colorectal cancer cell growth process by regulating miR-125a/CREB5 axis.			hsa_circ_VAPA	VAPA	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circVAPA is up-regulated in colorectal cancer tissues and cell lines. Functionally, circVAPA promotes CRC cell cycle progression, migration/invasion and aerobic glycolysis. Mechanistically, circVAPA acts as a ceRNA by sponging miR-125a to increase CREB5 expression (circVAPA/miR-125a/CREB5 axis)."	0.7911
32264877	Molecular cancer	2020	The circRNA circSEPT9 mediated by E2F1 and EIF4A3 facilitates the carcinogenesis and development of triple-negative breast cancer.	hsa_circ_0005320		hsa_circ_SEPT9	SEPT9	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circSEPT9 (hsa_circ_0005320), derived from SEPT9, is up-regulated in TNBC and promotes proliferation, migration/invasion, tumor growth and metastasis. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-637 to increase LIF and activate LIF/STAT3 signaling; E2F1 and EIF4A3 promote its biogenesis/expression. High circSEPT9 expression correlates with advanced stage and poor overall survival, supporting its prognostic/diagnostic potential."	0.8972
32266033	Experimental and therapeutic medicine	2020	CircRNA_101951 promotes migration and invasion of colorectal cancer cells by regulating the KIF3A-mediated EMT pathway.		circRNA_101951			colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circRNA_101951 is upregulated in colorectal cancer tissues and CRC cell lines and is associated with worse patient survival. Knockdown suppresses proliferation, colony formation, migration and invasion while increasing apoptosis and inducing G1 arrest, partly by inhibiting the KIF3A-mediated EMT program."	0.6778
32268875	"Molecular medicine (Cambridge, Mass.)"	2020	circKIF4A promotes tumorogenesis of glioma by targeting miR-139-3p to activate Wnt5a signaling.	hsa_circ_0090956		hsa_circ_KIF4A	KIF4A	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circKIF4A is up-regulated in glioma tissues and cell lines and promotes malignant phenotypes (proliferation, migration/invasion, stem-like sphere formation) while inhibiting apoptosis. Mechanistically, it sponges miR-139-3p to upregulate Wnt5a and activate Wnt/beta-catenin signaling, enhancing tumor growth in xenograft models."	0.6917
32273712	OncoTargets and therapy	2020	"Circular RNA 0060745, a Novel circRNA, Promotes Colorectal Cancer Cell Proliferation and Metastasis Through miR-4736 Sponging."	hsa_circ_0060745		hsa_circ_CSE1L	CSE1L	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0060745 is up-regulated in colorectal cancer and mainly localizes to the cytoplasm. It promotes CRC cell proliferation, migration/invasion and metastasis by sponging miR-4736, thereby relieving repression of the downstream target CSE1L (circ_0060745/miR-4736/CSE1L axis). High circ_0060745 expression is associated with shorter survival time and shows diagnostic potential by ROC analysis."	0.859
32273713	OncoTargets and therapy	2020	CircRNA ZNF609 Knockdown Suppresses Cell Growth via Modulating miR-188/ELF2 Axis in Nasopharyngeal Carcinoma.			hsa_circ_ZNF609	ZNF609	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"circ-ZNF609 is up-regulated in nasopharyngeal carcinoma tissues/cells and promotes NPC cell growth. Mechanistically, circ-ZNF609 sponges miR-188, thereby relieving miR-188-mediated repression of ELF2, which enhances proliferation/cell-cycle progression and reduces apoptosis."	0.6811
32273769	Cancer management and research	2020	Circ-ABCB10 Contributes to Paclitaxel Resistance in Breast Cancer Through Let-7a-5p/DUSP7 Axis.			hsa_circ_ABCB10	ABCB10	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ-ABCB10 is up-regulated in PTX-resistant breast cancer tissues/cells and promotes paclitaxel resistance. Functionally, its knockdown increases PTX sensitivity and apoptosis while reducing invasion and autophagy, and suppresses xenograft tumor growth. Mechanistically, circ-ABCB10 sponges let-7a-5p to relieve repression of DUSP7 (circ-ABCB10/let-7a-5p/DUSP7 ceRNA axis)."	0.6542
32281302	Cancer medicine	2020	Piplartine attenuates the proliferation of hepatocellular carcinoma cells via regulating hsa_circ_100338 expression.		hsa_circ_100338		ZEB1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circ-100338 is up-regulated in HCC cell lines and mainly localizes to the cytoplasm. It promotes HCC cell proliferation by acting as a ceRNA that sponges miR-141-3p, thereby increasing ZEB1 expression; piplartine suppresses proliferation partly by reducing circ-100338."	0.7893
32292503	Theranostics	2020	circPRRC2A promotes angiogenesis and metastasis through epithelial-mesenchymal transition and upregulates TRPM3 in renal cell carcinoma.			hsa_circ_PRRC2A	PRRC2A	Renal Cell Carcinoma 	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR; Microarray	"circPRRC2A is up-regulated in RCC/mRCC and promotes angiogenesis, EMT, and metastatic behaviors. It acts as a cytoplasmic ceRNA sponging miR-514a-5p and miR-6776-5p to increase TRPM3 (and downstream EMT markers), and higher circPRRC2A indicates worse patient survival."	0.8941
32292524	Theranostics	2020	Circular RNA SAMD4A controls adipogenesis in obesity through the miR-138-5p/EZH2 axis.	hsa_circ_0004846		hsa_circ_SAMD4A	hSAMD4A	obesity 	MONDO:0011122	obesity disorder	up-regulated	RT-qPCR; ISH; Microarray	"circSAMD4A (hsa_circ_0004846), derived from hSAMD4A, is up-regulated in visceral adipose tissue of obese patients and predominantly localized in the cytoplasm. It promotes preadipocyte differentiation by sponging miR-138-5p, thereby relieving repression of EZH2 and supporting an circSAMD4A/miR-138-5p/EZH2 regulatory axis. High circSAMD4A expression is associated with poor prognosis (non-remission) after bariatric surgery and shows diagnostic performance by ROC analysis."	0.8965
32292524	Theranostics	2020	Circular RNA SAMD4A controls adipogenesis in obesity through the miR-138-5p/EZH2 axis.	mmu_circ_0000529				obesity 	MONDO:0011122	obesity disorder	unknown	RT-qPCR	"mmu_circ_0000529, a mouse circRNA homologous to human circSAMD4A, was tested in an HFD-induced obesity mouse model. AAV9-mediated knockdown of mmu_circ_0000529 reduced obesity-related phenotypes including body weight and fat mass and improved insulin sensitivity and glucose tolerance. The downstream mechanism was not directly established for the mouse circRNA in the provided text."	0.3513
32293004	Bioscience reports	2020	Circular RNA hsa_circ_0072309 inhibits non-small cell lung cancer progression by sponging miR-580-3p.	hsa_circ_0072309				non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0072309 is down-regulated in NSCLC tissues and cell lines. Its overexpression suppresses NSCLC cell proliferation, migration and invasion by acting as a cytoplasmic miRNA sponge that directly binds miR-580-3p, and it is proposed as a diagnostic biomarker/therapeutic target for NSCLC."	0.7372
32299063	Aging	2020	"circTNFRSF21, a newly identified circular RNA promotes endometrial carcinoma pathogenesis through regulating miR-1227-MAPK13/ATF2 axis."	hsa_circ_0001610		hsa_circ_TNFRSF21	TNFRSF21	endometrial carcinoma 	MONDO:0002447	endometrial carcinoma	up-regulated	RT-qPCR	"circTNFRSF21 is up-regulated in endometrial carcinoma tissues and cell lines and promotes proliferation, cell-cycle progression, and xenograft tumor growth while inhibiting apoptosis. It functions as a ceRNA that sponges miR-1227, thereby restoring MAPK13 expression and activating downstream ATF2 signaling, forming a circTNFRSF21/miR-1227/MAPK13/ATF2 axis with therapeutic potential."	0.8274
32305958	Aging	2020	Circular RNA circRGNEF promotes bladder cancer progression via miR-548/KIF2C axis regulation.	hsa_circ_0072995	circRGNEF	hsa_circ_RGNEF	RGNEF	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; RNA-seq	"circRGNEF (hsa_circ_0072995) is up-regulated in bladder cancer tissues and cell lines and is mainly localized in the cytoplasm. It promotes proliferation, migration/invasion and metastasis by acting as a miR-548 sponge to increase KIF2C expression, and high circRGNEF levels are associated with aggressive clinicopathological features and poorer overall survival."	0.8156
32305992	Medical science monitor : international medical journal of experimental and clinical research	2020	Integrin Subunit Alpha 5 (ITGA5) Gene Circular RNA Sponges microRNA-107 in Colorectal Carcinoma Cells and Tissues and Regulates the Expression of the Forkhead Box J3 (FOXJ3) Gene.	hsa_circ_0026735		hsa_circ_ITGA5	ITGA5	colorectal carcinoma 	MONDO:0024331	colorectal carcinoma	down-regulated	RT-qPCR	"In colorectal carcinoma, ITGA5 circRNA (hsa_circ_0026735) is down-regulated and functions as a tumor suppressor. It sponges miR-107, thereby relieving miR-107-mediated repression of FOXJ3 and inhibiting CRC cell proliferation/migration while promoting apoptosis."	0.7113
32308410	OncoTargets and therapy	2020	Genome-Wide Microarray Analysis of circRNAs Revealed Novel Biomarkers for Glioma Treatment and Their Promoting Effect on Glioma Progression.	hsa_circ_0013520				glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0013520 is up-regulated in glioma tissues and cell lines. Its high expression correlates with worse clinical features and poorer overall survival, and knockdown suppresses glioma cell proliferation and migration/invasion."	0.6616
32308410	OncoTargets and therapy	2020	Genome-Wide Microarray Analysis of circRNAs Revealed Novel Biomarkers for Glioma Treatment and Their Promoting Effect on Glioma Progression.	hsa_circ_0004379				glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0004379 is up-regulated in glioma tissues and cell lines. Its high expression correlates with worse clinical features and poorer overall survival, and knockdown suppresses glioma cell proliferation and migration/invasion."	0.6616
32308410	OncoTargets and therapy	2020	Genome-Wide Microarray Analysis of circRNAs Revealed Novel Biomarkers for Glioma Treatment and Their Promoting Effect on Glioma Progression.	hsa_circ_0037655				glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0037655 is up-regulated in glioma tissues and cell lines and was among the top up-regulated candidates from microarray screening, but it was not significantly correlated with key clinical features in this cohort and no functional/mechanistic assays were reported for it."	0.4032
32308420	OncoTargets and therapy	2020	CircRNA hsa_circ_0087862 Acts as an Oncogene in Non-Small Cell Lung Cancer by Targeting miR-1253/RAB3D Axis.	hsa_circ_0087862				non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0087862 is up-regulated in NSCLC and functions as an oncogenic circRNA. It promotes proliferation/viability, migration and invasion while inhibiting apoptosis, and it enhances xenograft tumor growth. Mechanistically, it sponges miR-1253 to increase the downstream target RAB3D, and higher circRNA expression is associated with poorer patient survival."	0.8282
32308427	OncoTargets and therapy	2020	Identification of circRNA-miRNA-mRNA Networks for Exploring the Fundamental Mechanism in Lung Adenocarcinoma.	hsa_circ_0072088		hsa_circ_ZFR	ZFR	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	hsa_circ_0072088 is up-regulated in lung adenocarcinoma and was validated in matched tissues and LUAD cell lines. The study predicts it may act as a ceRNA by sponging miRNAs (notably miR-578/miR-944) to influence downstream cancer-related genes and pathways including TGF-beta-related responses and MAPK/PI3K-AKT signaling.	0.5739
32308427	OncoTargets and therapy	2020	Identification of circRNA-miRNA-mRNA Networks for Exploring the Fundamental Mechanism in Lung Adenocarcinoma.	hsa_circ_0008274		hsa_circ_UGGT2	UGGT2	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; RNA-seq; Microarray	hsa_circ_0008274 is down-regulated in lung adenocarcinoma and was validated in matched tissues and LUAD cell lines. The study predicts a ceRNA mechanism involving miR-578/miR-633 and downstream genes linked to EMT and cancer-related signaling pathways including MAPK and PI3K/AKT/mTOR.	0.5739
32308483	Cancer management and research	2020	Circular RNA Circ-ZNF609 Promotes Lung Adenocarcinoma Proliferation by Modulating miR-1224-3p/ETV1 Signaling.	hsa_circ_0000615		hsa_circ_ZNF609	ZNF609	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"circ-ZNF609 is up-regulated in lung adenocarcinoma tissues and cell lines and promotes tumor cell proliferation and G0/G1-to-S progression. It functions as a ceRNA by sponging miR-1224-3p, thereby increasing ETV1 expression and driving malignant growth."	0.7277
32308490	Cancer management and research	2020	Serum Circular FoxO3a Serves as a Novel Prognostic Biomarker in Squamous Cervical Cancer.			hsa_circ_FoxO3	FoxO3	squamous cervical cancer 	MONDO:0006143	cervical squamous cell carcinoma	down-regulated	RT-qPCR	"Serum circFoxO3a is down-regulated in squamous cervical cancer patients. Lower serum circFoxO3a correlates with aggressive clinicopathologic features and independently predicts worse OS and RFS, supporting its use as a noninvasive prognostic biomarker."	0.6355
32308563	Cancer cell international	2020	A novel circular RNA circENTPD7 contributes to glioblastoma progression by targeting ROS1.	hsa_circ_0019421		hsa_circ_ENTPD7	ENTPD7	glioblastoma 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; Microarray	"circENTPD7 is up-regulated in glioblastoma tissues/cells and promotes proliferation and motility. Mechanistically, it functions as a ceRNA by sponging miR-101-3p to increase ROS1 expression, and its knockdown suppresses xenograft tumor growth. High circENTPD7 expression is associated with shorter overall survival in glioblastoma patients."	0.8537
32308754	Theranostics	2020	Circular RNA circFBXW4 suppresses hepatic fibrosis via targeting the miR-18b-3p/FBXW7 axis.	mm9_circ_000338		mmu_circ_FBXW4	FBXW4	hepatic fibrosis 	MONDO:0100430	fibrotic liver disease	down-regulated	RT-qPCR; RNA-seq	"circFBXW4 is down-regulated during hepatic fibrosis and functions as an anti-fibrotic circRNA by inhibiting HSC activation and proliferation while promoting apoptosis, alleviating fibrogenesis and inflammation in vivo. Mechanistically, it acts as a ceRNA sponge for miR-18b-3p to increase FBXW7 expression (and modulate downstream targets such as Yap1). circFBXW4 is also reduced in human fibrotic liver tissues, supporting potential biomarker/therapeutic relevance."	0.8705
32308754	Theranostics	2020	Circular RNA circFBXW4 suppresses hepatic fibrosis via targeting the miR-18b-3p/FBXW7 axis.	hsa_circ_0008362		hsa_circ_FBXW4	FBXW4	hepatic fibrosis 	MONDO:0100430	fibrotic liver disease	down-regulated	RT-qPCR; RNA-seq	"circFBXW4 is down-regulated during hepatic fibrosis and functions as an anti-fibrotic circRNA by inhibiting HSC activation and proliferation while promoting apoptosis, alleviating fibrogenesis and inflammation in vivo. Mechanistically, it acts as a ceRNA sponge for miR-18b-3p to increase FBXW7 expression (and modulate downstream targets such as Yap1). circFBXW4 is also reduced in human fibrotic liver tissues, supporting potential biomarker/therapeutic relevance."	0.8705
32309852	Bioscience reports	2020	Circular RNA expression profile of lung squamous cell carcinoma: identification of potential biomarkers and therapeutic targets.	hsa_circ_0014235		hsa_circ_S100A2	S100A2	lung squamous cell carcinoma 	MONDO:0005097	squamous cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0014235 is up-regulated in plasma exosomes from LUSC patients and shows diagnostic potential (AUC ~0.83). It is associated with more advanced clinical features (higher TNM stage and larger tumor size), and bioinformatic analyses suggest involvement in cancer-related processes via a predicted circRNA_miRNA_mRNA network."	0.6548
32309852	Bioscience reports	2020	Circular RNA expression profile of lung squamous cell carcinoma: identification of potential biomarkers and therapeutic targets.	hsa_circ_0025580		hsa_circ_SLCO1B3	SLCO1B3	lung squamous cell carcinoma 	MONDO:0005097	squamous cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0025580 is up-regulated in plasma exosomes from LUSC patients and has diagnostic value by ROC analysis. Its higher expression correlates with advanced TNM stage and larger tumor size, and it is included in a predicted circRNA_miRNA_mRNA network linked to cancer-related processes."	0.6548
32312268	BMC medical genomics	2020	Islet-expressed circular RNAs are associated with type 2 diabetes status in human primary islets and in peripheral blood.		circCIRBP	hsa_circ_CIRBP	CIRBP	type 2 diabetes 	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RT-qPCR	"circCIRBP is down-regulated in islets from donors with T2D and shows a negative association with insulin secretory index. In EndoC-betaH1 cells, circCIRBP increases after palmitate treatment, suggesting responsiveness to lipid-related stress, but the study does not establish a causal mechanism."	0.2995
32312268	BMC medical genomics	2020	Islet-expressed circular RNAs are associated with type 2 diabetes status in human primary islets and in peripheral blood.		circCAMSAP1	hsa_circ_CAMSAP1	CAMSAP1	type 2 diabetes 	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RT-qPCR	"circCAMSAP1 is elevated in islets from donors with T2D and is also associated with T2D status in peripheral blood, but in the opposite direction to islets. The paper suggests a possible relationship to CAMSAP1/microtubule-related processes relevant to insulin secretion, while emphasizing the findings are largely correlative."	0.2995
32312268	BMC medical genomics	2020	Islet-expressed circular RNAs are associated with type 2 diabetes status in human primary islets and in peripheral blood.		circRPH3AL	hsa_circ_RPH3AL	RPH3AL	type 2 diabetes 	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RT-qPCR	circRPH3AL is up-regulated in islets from donors with T2D and is altered by lipid stress in EndoC-betaH1 cells (decreased after palmitate). The study reports associations but does not establish a molecular mechanism.	0.2995
32312268	BMC medical genomics	2020	Islet-expressed circular RNAs are associated with type 2 diabetes status in human primary islets and in peripheral blood.		circZKSCAN1 / circZKSCAN	hsa_circ_ZKSCAN1	ZKSCAN1	type 2 diabetes 	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RT-qPCR	"circZKSCAN1 shows a nominal association with T2D status in human islets and is discussed in the context of inhibiting cellular proliferation/survival. It is detectable in peripheral blood in this study, but the reported blood association with T2D status is for circCAMSAP1 rather than circZKSCAN1."	0.2995
32314520	Cancer medicine	2020	CircSMC3 regulates gastric cancer tumorigenesis by targeting miR-4720-3p/TJP1 axis.	hsa_circ_0000260	circSMC3	hsa_circ_SMC3	SMC3	gastric cancer	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circSMC3 is up-regulated in gastric cancer tissues and cell lines and functions as an oncogenic circRNA. It sponges miR-4720-3p, relieving repression of TJP1, thereby promoting gastric cancer cell proliferation and motility and enhancing xenograft tumor growth; high circSMC3 predicts shorter overall survival."	0.8558
32318575	Frontiers in medicine	2020	CircHIPK3 Promotes Pyroptosis in Acinar Cells Through Regulation of the miR-193a-5p/GSDMD Axis.	hsa_circ_0000284		hsa_circ_HIPK3	HIPK3	acute pancreatitis 	MONDO:0006515	acute pancreatitis	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in AP patient serum and in caerulein-stimulated AR42J acinar cells. It promotes inflammatory injury and pyroptosis by sponging miR-193a-5p to increase GSDMD expression, leading to caspase-1/11 activation and cytokine release; it is proposed as a diagnostic biomarker and therapeutic target for AP."	0.6152
32319610	Molecular medicine reports	2020	Circular RNA expression profiling identifies specific circular RNAs in tongue squamous cell carcinoma.		hsa_circRNA_081069	hsa_circ_COL1A2	COL1A2	tongue squamous cell carcinoma 	MONDO:0000500	tongue squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circ_081069 (host gene COL1A2) is up-regulated in TSCC tissues and promotes TSCC cell migration and proliferation in vitro. Mechanistically, it can bind miR-665 consistent with a ceRNA-like miRNA sponge interaction, supported by bioinformatic prediction and luciferase reporter assays."	0.6676
32319610	Molecular medicine reports	2020	Circular RNA expression profiling identifies specific circular RNAs in tongue squamous cell carcinoma.		hsa_circRNA_087212	hsa_circ_ANXA1	ANXA1	tongue squamous cell carcinoma 	MONDO:0000500	tongue squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	"circ_087212 (host gene ANXA1) is down-regulated in TSCC tissues and was validated by RT-qPCR. The study performed bioinformatic prediction of circ_087212_miRNA interactions (e.g., miR-29a-5p) but did not experimentally validate a functional mechanism for circ_087212."	0.4032
32319610	Molecular medicine reports	2020	Circular RNA expression profiling identifies specific circular RNAs in tongue squamous cell carcinoma.		hsa_circRNA_045179	hsa_circ_TANC2	TANC2	tongue squamous cell carcinoma 	MONDO:0000500	tongue squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	circ_045179 (host gene TANC2) was identified as up-regulated in TSCC by circRNA microarray and its differential expression was confirmed by RT-qPCR in paired TSCC vs paracancer tissues. The study did not further characterize its functional role or mechanism.	0.3588
32319610	Molecular medicine reports	2020	Circular RNA expression profiling identifies specific circular RNAs in tongue squamous cell carcinoma.		hsa_circRNA_000317	hsa_circ_AHNAK	AHNAK	tongue squamous cell carcinoma 	MONDO:0000500	tongue squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	circ_000317 (host gene AHNAK) was identified as down-regulated in TSCC by microarray and its differential expression was confirmed by RT-qPCR in paired TSCC vs paracancer tissues. The study did not further explore its mechanism or function.	0.3588
32319610	Molecular medicine reports	2020	Circular RNA expression profiling identifies specific circular RNAs in tongue squamous cell carcinoma.		hsa_circRNA_000780	hsa_circ_FAM107B	FAM107B	tongue squamous cell carcinoma 	MONDO:0000500	tongue squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	circ_000780 (host gene FAM107B) was identified as down-regulated in TSCC by microarray and its differential expression was confirmed by RT-qPCR. The study did not report further functional or mechanistic experiments for this circRNA.	0.3588
32319610	Molecular medicine reports	2020	Circular RNA expression profiling identifies specific circular RNAs in tongue squamous cell carcinoma.		hsa_circRNA_102039	hsa_circ_TAF15	TAF15	tongue squamous cell carcinoma 	MONDO:0000500	tongue squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	circ_102039 (host gene TAF15) was found down-regulated in TSCC by microarray and validated by RT-qPCR in paired TSCC vs paracancer tissues. No specific downstream mechanism or function was experimentally investigated for this circRNA in the study.	0.3588
32319610	Molecular medicine reports	2020	Circular RNA expression profiling identifies specific circular RNAs in tongue squamous cell carcinoma.		hsa_circRNA_003251	hsa_circ_WNK1	WNK1	tongue squamous cell carcinoma 	MONDO:0000500	tongue squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	circ_003251 (host gene WNK1) was detected as down-regulated in TSCC by microarray and validated by RT-qPCR in paired clinical tissues. The paper did not provide mechanistic or functional experiments specifically for circ_003251.	0.3588
32319613	International journal of oncology	2020	circRNA_001275 upregulates Wnt7a expression by competitively sponging miR_370_3p to promote cisplatin resistance in esophageal cancer.		circRNA_001275			cisplatin-resistant esophageal cancer 	MONDO:0019086	carcinoma of esophagus	up-regulated	RT-qPCR; Microarray	"circRNA_001275 is upregulated in cisplatin-resistant esophageal cancer tissues and resistant cell lines and promotes malignant phenotypes and cisplatin resistance. Mechanistically, it functions as a sponge for miR-370-3p to relieve repression of Wnt7a, increasing Wnt7a mRNA/protein expression."	0.6593
32319627	Molecular medicine reports	2020	Circular RNA hsa_circ_0001380 in peripheral blood as a potential diagnostic biomarker for active pulmonary tuberculosis.	hsa_circ_0001380	hsa_circUBXN7_006	hsa_circ_UBXN7	UBXN7	active pulmonary tuberculosis 	MONDO:0006052	pulmonary tuberculosis	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001380 (derived from UBXN7) is significantly downregulated in PBMCs/peripheral blood of active pulmonary tuberculosis patients and shows strong diagnostic performance by ROC analysis (AUC 0.9502). Its miRNA binding (miR-622/miR-136-5p) and m6A sites were predicted in silico, but downstream targets and mechanisms were not experimentally validated."	0.6548
32319701	Journal of clinical laboratory analysis	2020	Circular RNA 0016788 displays as a biomarker for tumor progression and poor prognosis in surgical hepatocellular carcinoma patients.	hsa_circ_0016788				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"Circ_0016788 is up-regulated in resected HCC tumor tissues and can discriminate tumor from adjacent tissue. High tumor circ_0016788 expression is associated with more aggressive clinicopathological features and independently predicts shorter overall survival. The paper discusses potential mechanisms including miR-486/CDK4 regulation, enhanced glycolysis, and Wnt/beta-catenin pathway activation."	0.5918
32320103	Journal of clinical laboratory analysis	2020	A potential disease monitoring and prognostic biomarker in cervical cancer patients: The clinical application of circular RNA_0018289.	hsa_circ_0018289				cervical cancer	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"In this prospective cohort of cervical cancer patients, circ_0018289 was up-regulated in tumor tissue versus paired adjacent tissue by RT-qPCR. High tumor circ_0018289 expression was associated with more advanced clinicopathologic features and predicted worse DFS/OS, and it independently predicted worse DFS."	0.5918
32323783	Molecular medicine reports	2020	Circular RNA Circ100084 functions as sponge of miR_23a_5p to regulate IGF2 expression in hepatocellular carcinoma.		hsa_circ_100084	hsa_circ_EIF4G3	EIF4G3	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"In hepatocellular carcinoma, hsa_circRNA_100084 (circEIF4G3) is upregulated and promotes liver cancer cell proliferation, migration and invasion. Mechanistically, it functions as a ceRNA by sponging hsa-miR-23a-5p to increase IGF2 expression."	0.6676
32323838	Oncology reports	2020	Comprehensive circular RNA expression profiling with associated ceRNA network reveals their therapeutic potential in cholesteatoma.		hsa_circRNA_102747	hsa_circ_ACTR2	ACTR2	cholesteatoma	MONDO:0006530	cholesteatoma	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_102747 (host gene ACTR2) is down-regulated in cholesteatoma tissue and was validated by RT-qPCR. The study predicts it may function as a ceRNA/miRNA sponge for miR-21-3p (together with lncRNA-uc001kfc.1), affecting downstream target mRNAs and potentially contributing to keratinocyte hyper-proliferation, suggesting therapeutic potential."	0.4032
32323838	Oncology reports	2020	Comprehensive circular RNA expression profiling with associated ceRNA network reveals their therapeutic potential in cholesteatoma.		hsa_circRNA_101458	hsa_circ_HERC2P3	HERC2P3	cholesteatoma	MONDO:0006530	cholesteatoma	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_101458 (host gene HERC2P3) is down-regulated in cholesteatoma and was RT-qPCR validated. The study predicts it may sponge miR let-7a-3p in a ceRNA axis to influence downstream target mRNAs, potentially contributing to anti-proliferative regulation in cholesteatoma keratinocytes and representing a possible therapeutic target."	0.4032
32323838	Oncology reports	2020	Comprehensive circular RNA expression profiling with associated ceRNA network reveals their therapeutic potential in cholesteatoma.		hsa_circRNA_084725			cholesteatoma	MONDO:0006530	cholesteatoma	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_084725 is reported as up-regulated in cholesteatoma versus normal skin and its microarray result was validated by RT-qPCR, but no mechanism or functional role was further characterized."	0.3588
32323838	Oncology reports	2020	Comprehensive circular RNA expression profiling with associated ceRNA network reveals their therapeutic potential in cholesteatoma.		hsa_circRNA_103276			cholesteatoma	MONDO:0006530	cholesteatoma	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_103276 is reported as up-regulated in cholesteatoma versus normal skin and its microarray result was validated by RT-qPCR, but no additional mechanism or functional role was described."	0.3588
32323838	Oncology reports	2020	Comprehensive circular RNA expression profiling with associated ceRNA network reveals their therapeutic potential in cholesteatoma.		hsa_circRNA_006562			cholesteatoma	MONDO:0006530	cholesteatoma	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_006562 is reported as down-regulated in cholesteatoma versus normal skin and its microarray result was validated by RT-qPCR, but no mechanism or functional role was characterized."	0.3588
32323838	Oncology reports	2020	Comprehensive circular RNA expression profiling with associated ceRNA network reveals their therapeutic potential in cholesteatoma.		hsa_circRNA_101965			cholesteatoma	MONDO:0006530	cholesteatoma	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_101965 is reported as down-regulated in cholesteatoma versus normal skin and its microarray result was validated by RT-qPCR, but no mechanism or functional role was further characterized."	0.3588
32328186	Journal of Cancer	2020	Screening Circular RNAs Related to Acquired Gefitinib Resistance in Non-small Cell Lung Cancer Cell Lines.	hsa_circ_0000567		hsa_circ_SETD3	SETD3	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000567 (host gene SETD3) is consistently up-regulated in gefitinib-resistant NSCLC cell lines and is proposed to modulate gefitinib sensitivity. The study predicts it may function as a miRNA sponge (e.g., binding hsa-miR-1226-5p, hsa-miR-762, hsa-miR-593-5p, hsa-miR-149-5p, hsa-miR-939-3p) to influence downstream mRNAs implicated in resistance (e.g., MET, AKT1, ABCB1, IGF1R)."	0.3858
32328186	Journal of Cancer	2020	Screening Circular RNAs Related to Acquired Gefitinib Resistance in Non-small Cell Lung Cancer Cell Lines.	hsa_circ_0006867		hsa_circ_LRBA	LRBA	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0006867 (host gene LRBA) is consistently down-regulated in gefitinib-resistant NSCLC cell lines. The study predicts it may function as a miRNA sponge (e.g., binding hsa-miR-204-3p, hsa-miR-671- 5p, hsa-miR-145-5p, hsa-miR-1237-3p, hsa-miR- 1182) and influence downstream mRNAs implicated in gefitinib resistance and lung cancer overall survival (based on target mRNA analyses)."	0.3858
32328195	Journal of Cancer	2020	Cell proliferation and invasion is promoted by circSERPINA3 in nasopharyngeal carcinoma by regulating miR-944/MDM2 axis.	hsa_circ_0033074		hsa_circ_SERPINA3	SERPINA3	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"circSERPINA3 (hsa_circ_0033074), derived from SERPINA3, is up-regulated in NPC tissues and cell lines and promotes NPC cell proliferation and invasion. Mechanistically, it mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-944 to de-repress MDM2, forming the circSERPINA3/miR-944/MDM2 axis. High circSERPINA3 expression correlates with advanced stage/lymph-node metastasis and poorer overall survival."	0.7967
32330870	Molecular therapy. Nucleic acids	2020	circHMCU Promotes Proliferation and Metastasis of Breast Cancer by Sponging the let-7 Family.	hsa_circ_0000247		hsa_circ_MCU	MCU	breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circHMCU (hsa_circ_0000247), derived from MCU, is up-regulated in breast cancer tissues and aggressive/metastatic breast cancer cell sublines and is mainly cytoplasmic. It promotes proliferation and metastasis (EMT, migration/invasion, lung metastasis) by sponging let-7 family miRNAs, thereby increasing let-7 target genes including MYC, HMGA2 and CCND1; high circHMCU is associated with poor patient prognosis."	0.8824
32332704	Cell death & disease	2020	CircGCN1L1 promotes synoviocyte proliferation and chondrocyte apoptosis by targeting miR-330-3p and TNF-alpha in TMJ osteoarthritis.	hsa_circ_0000448		hsa_circ_GCN1L1	GCN1L1	temporomandibular joint osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; RNA-seq	"circGCN1L1 is up-regulated in TMJOA synovial tissues/cells and predominantly localizes in the cytoplasm. It functions as a ceRNA/miRNA sponge for miR-330-3p, thereby relieving repression on TNF (TNF-alpha) and promoting inflammatory responses, synoviocyte proliferation, chondrocyte apoptosis, and ECM catabolism; shcircGCN1L1 injection alleviates TMJOA in rats."	0.8072
32332879	Scientific reports	2020	Circ-camk4 involved in cerebral ischemia/reperfusion induced neuronal injury.			rno_circ_camk4	camk4	stroke 	MONDO:0005098	stroke disorder	up-regulated	RT-qPCR; RNA-seq	"circ-camk4 is up-regulated early after cerebral ischemia/reperfusion in rat cortex and OGD/R neuronal models. It sponges miR-27a-3p, miR-324-3p and miR-212-3p and is linked to MAPK and apoptosis-related processes, promoting neuronal cell death."	0.6054
32332879	Scientific reports	2020	Circ-camk4 involved in cerebral ischemia/reperfusion induced neuronal injury.			hsa_circ_CAMK4		stroke 	MONDO:0005098	stroke disorder	up-regulated	RT-qPCR	"In SH-SY5Y cells under OGD/R, hsa-circ-camk4 is increased and its overexpression aggravates neuronal cell death, supporting a harmful/pro-apoptotic role in ischemia/reperfusion-related injury in vitro."	0.2586
32342645	Journal of cellular and molecular medicine	2020	Circular RNA MYLK promotes tumour growth and metastasis via modulating miR-513a-5p/VEGFC signalling in renal cell carcinoma.			hsa_circ_MYLK	MYLK	renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR	"circMYLK is up-regulated in renal cell carcinoma and is associated with larger tumor size, distant metastasis, and poorer overall survival. Functionally, circMYLK promotes RCC proliferation, migration/invasion, EMT, and metastasis. Mechanistically, it localizes mainly in the cytoplasm and acts as a ceRNA that sponges miR-513a-5p to increase VEGFC expression."	0.8037
32344560	International journal of molecular sciences	2020	Transcriptomic Profiling of Circular RNA in Different Brain Regions of Parkinson's Disease in a Mouse Model.	mmu_circ_0003292				Parkinson¡¯s disease 	MONDO:0005180	Parkinson disease	unknown	RT-qPCR; RNA-seq	"In an MPTP-induced Parkinson¡¯s disease mouse model, mmu_circRNA_0003292 is differentially expressed across brain regions and was validated by qRT-PCR. Bioinformatics analysis suggests it may act as a miRNA-132 sponge to regulate Nr4a2, potentially contributing to PD-related molecular mechanisms."	0.5922
32344560	International journal of molecular sciences	2020	Transcriptomic Profiling of Circular RNA in Different Brain Regions of Parkinson's Disease in a Mouse Model.	mmu_circ_0000870				Parkinson¡¯s disease 	MONDO:0005180	Parkinson disease	unknown	RT-qPCR; RNA-seq	mmu_circRNA_0000870 was among the circRNAs selected for qRT-PCR validation and showed region-specific expression (lowest in striatum and highest in cerebellum) in the MPTP-induced PD mouse model.	0.4851
32344560	International journal of molecular sciences	2020	Transcriptomic Profiling of Circular RNA in Different Brain Regions of Parkinson's Disease in a Mouse Model.	mmu_circ_0000517				Parkinson¡¯s disease 	MONDO:0005180	Parkinson disease	unknown	RT-qPCR; RNA-seq	"mmu_circRNA_0000517 was selected for qRT-PCR validation and displayed region-specific expression, being highest in the striatum in the PD mouse model."	0.4851
32344560	International journal of molecular sciences	2020	Transcriptomic Profiling of Circular RNA in Different Brain Regions of Parkinson's Disease in a Mouse Model.	mmu_circ_0004144				Parkinson¡¯s disease 	MONDO:0005180	Parkinson disease	down-regulated	RT-qPCR; RNA-seq	"mmu_circRNA_0004144 was identified as a DE-circRNA and was significantly down-regulated in the PD group in this MPTP-induced mouse model, with qRT-PCR results consistent with RNA-seq."	0.4851
32344560	International journal of molecular sciences	2020	Transcriptomic Profiling of Circular RNA in Different Brain Regions of Parkinson's Disease in a Mouse Model.	mmu_circ_0000468				Parkinson¡¯s disease 	MONDO:0005180	Parkinson disease	down-regulated	RT-qPCR; RNA-seq	"mmu_circRNA_0000468 was significantly down-regulated in the PD group in this MPTP-induced mouse model, supported by qRT-PCR validation consistent with RNA-seq."	0.4851
32344560	International journal of molecular sciences	2020	Transcriptomic Profiling of Circular RNA in Different Brain Regions of Parkinson's Disease in a Mouse Model.	mmu_circ_0013321				Parkinson¡¯s disease 	MONDO:0005180	Parkinson disease	down-regulated	RT-qPCR; RNA-seq	"mmu_circRNA_0013321 was significantly down-regulated in the PD group in this MPTP-induced mouse model, with qRT-PCR validation consistent with RNA-seq."	0.4851
32344560	International journal of molecular sciences	2020	Transcriptomic Profiling of Circular RNA in Different Brain Regions of Parkinson's Disease in a Mouse Model.	mmu_circ_0001320				Parkinson¡¯s disease 	MONDO:0005180	Parkinson disease	up-regulated	RT-qPCR; RNA-seq	"mmu_circRNA_0001320 is up-regulated in the PD group in an MPTP-induced mouse model and was validated by qRT-PCR. Network analysis predicts it may sponge miRNA-124, potentially influencing PD-related molecular processes."	0.4851
32344560	International journal of molecular sciences	2020	Transcriptomic Profiling of Circular RNA in Different Brain Regions of Parkinson's Disease in a Mouse Model.	mmu_circ_0005976				Parkinson¡¯s disease 	MONDO:0005180	Parkinson disease	unknown	RNA-seq	"mmu_circRNA_0005976 was highlighted through KEGG enrichment of predicted target genes and included in the in silico circRNA_miRNA_mRNA network, suggesting potential involvement in PD-related pathways, without reported qRT-PCR validation for this circRNA."	0.31
32344560	International journal of molecular sciences	2020	Transcriptomic Profiling of Circular RNA in Different Brain Regions of Parkinson's Disease in a Mouse Model.	mmu_circ_0005388				Parkinson¡¯s disease 	MONDO:0005180	Parkinson disease	unknown	RNA-seq	"mmu_circRNA_0005388 was implicated by KEGG enrichment of predicted target genes and included in the constructed circRNA_miRNA_mRNA network, suggesting potential involvement in PD-related pathways, but without specific qRT-PCR validation reported for this circRNA."	0.31
32344560	International journal of molecular sciences	2020	Transcriptomic Profiling of Circular RNA in Different Brain Regions of Parkinson's Disease in a Mouse Model.	mmu_circ_0003328				Parkinson¡¯s disease 	MONDO:0005180	Parkinson disease	unknown	RNA-seq	mmu_circRNA_0003328 was highlighted by KEGG enrichment as being involved in Parkinson¡¯s-related pathways and was included among circRNAs considered in downstream network prediction; no specific expression direction or experimental validation was reported for this circRNA.	0.31
32344560	International journal of molecular sciences	2020	Transcriptomic Profiling of Circular RNA in Different Brain Regions of Parkinson's Disease in a Mouse Model.	mmu_circ_0012384				Parkinson¡¯s disease 	MONDO:0005180	Parkinson disease	unknown	RNA-seq	mmu_circRNA_0012384 was mentioned as being involved in Parkinson¡¯s-related pathways based on KEGG analysis; no specific expression direction or qRT-PCR validation was reported for this circRNA.	0.31
32346439	Experimental and therapeutic medicine	2020	"circ_0067934 increases bladder cancer cell proliferation, migration and invasion through suppressing miR-1304 expression and increasing Myc expression levels."	hsa_circ_0067934				bladder cancer	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circ_0067934 is up-regulated in bladder cancer tissues/cell lines and promotes malignant phenotypes (proliferation, migration, invasion). Mechanistically, it suppresses (sponges) miR-1304, thereby increasing Myc expression; high circ_0067934 is associated with metastasis and worse 5-year OS/DFS."	0.686
32353949	Cancers	2020	The Circular RNA Landscape of Non-Small Cell Lung Cancer Cells.		circPVT1	hsa_circ_PVT1	PVT1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	unknown	RT-qPCR; RNA-seq	"In NSCLC cell lines, circPVT1 overexpression promotes tumorigenic growth by significantly increasing colony formation."	0.4062
32353949	Cancers	2020	The Circular RNA Landscape of Non-Small Cell Lung Cancer Cells.		circERBB2	hsa_circ_ERBB2	ERBB2	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	unknown	RT-qPCR; RNA-seq	"In NSCLC cell lines, circERBB2 overexpression promotes tumorigenic growth by increasing colony formation."	0.4062
32353949	Cancers	2020	The Circular RNA Landscape of Non-Small Cell Lung Cancer Cells.		circHIPK3	hsa_circ_HIPK3	HIPK3	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	unknown	RT-qPCR; RNA-seq	"In NSCLC cell lines, circHIPK3 overexpression promotes colony-forming capacity, supporting an oncogenic role in this model."	0.4062
32353949	Cancers	2020	The Circular RNA Landscape of Non-Small Cell Lung Cancer Cells.		circCCNB1	hsa_circ_CCNB1	CCNB1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	unknown	RT-qPCR; RNA-seq	"circCCNB1 promotes NSCLC cell growth phenotypes in vitro, as its overexpression increases colony formation, consistent with a pro-proliferative/cell-cycle-related role."	0.4062
32353949	Cancers	2020	The Circular RNA Landscape of Non-Small Cell Lung Cancer Cells.		circTNFRSF21	hsa_circ_TNFRSF21	TNFRSF21	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	dysregulated	RT-qPCR; RNA-seq	"circTNFRSF21 is differentially expressed between tumor-derived and non-transformed lung cell lines, promotes colony formation when overexpressed, and has coding potential consistent with translation into an ~42 kDa protein crossing the backsplice site in two reading frames."	0.642
32353949	Cancers	2020	The Circular RNA Landscape of Non-Small Cell Lung Cancer Cells.		circKIF5B	hsa_circ_KIF5B	KIF5B	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	unknown	RT-qPCR; RNA-seq	circKIF5B (exon 24_20 backsplice) is associated with higher proliferation capacity across NSCLC cell lines and promotes colony formation when overexpressed.	0.4062
32353949	Cancers	2020	The Circular RNA Landscape of Non-Small Cell Lung Cancer Cells.		circSMAD2	hsa_circ_SMAD2	SMAD2	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	dysregulated	RT-qPCR; RNA-seq	"circSMAD2 is upregulated in fast-proliferating NSCLC cell lines and enhances colony formation upon overexpression, indicating a pro-growth role in vitro."	0.6166
32355738	Annals of translational medicine	2020	Identification and integrated analysis of hepatocellular carcinoma-related circular RNA signature.	hsa_circ_0004913	circTEX2	hsa_circ_TEX2	TEX2	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0004913 (circTEX2) was identified from GEO circRNA microarrays as differentially expressed in HCC and its up-regulation was validated by RT-qPCR in SMMC-7721 cells. The study suggests it may serve as a potential diagnostic biomarker for HCC, but no specific miRNA/mRNA axis was defined for this circRNA in the final regulatory conclusions."	0.4032
32355738	Annals of translational medicine	2020	Identification and integrated analysis of hepatocellular carcinoma-related circular RNA signature.	hsa_circ_0072389	circHMGCS1	hsa_circ_HMGCS1	HMGCS1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circ_0072389 (circHMGCS1) is up-regulated in HCC (validated by qPCR in SMMC-7721) and is proposed to drive HCC progression via ceRNA axes circHMGCS1/miR-581/AURKA and circHMGCS1/miR-892a/KIF5B. It is suggested as a potential biomarker for HCC detection.	0.2465
32355738	Annals of translational medicine	2020	Identification and integrated analysis of hepatocellular carcinoma-related circular RNA signature.	hsa_circ_0000517	circRPPH1	hsa_circ_RPPH1	RPPH1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000517 (circRPPH1) is one of six circRNAs found up-regulated in HCC and validated by RT-qPCR in SMMC-7721 cells. The paper proposes it as a potential diagnostic biomarker, without defining a specific miRNA/mRNA regulatory axis for it."	0.4032
32355738	Annals of translational medicine	2020	Identification and integrated analysis of hepatocellular carcinoma-related circular RNA signature.	hsa_circ_0031027	circTMCO3	hsa_circ_TMCO3	TMCO3	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circ_0031027 (circTMCO3) is up-regulated in HCC (validated by qPCR in SMMC-7721) and is implicated in HCC progression via a ceRNA axis circTMCO3/miR-577/RHOA. It is proposed as a potential biomarker for HCC detection.	0.2465
32355738	Annals of translational medicine	2020	Identification and integrated analysis of hepatocellular carcinoma-related circular RNA signature.	hsa_circ_0008160	circPIGP	hsa_circ_PIGP	PIGP	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0008160 (circPIGP) is one of the six circRNAs validated as up-regulated in HCC (qPCR in SMMC-7721). The study suggests it may have diagnostic biomarker potential, but provides no specific interaction axis for it."	0.4032
32355738	Annals of translational medicine	2020	Identification and integrated analysis of hepatocellular carcinoma-related circular RNA signature.	hsa_circ_0011536	circZMYM4	hsa_circ_ZMYM4	ZMYM4	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0011536 (circZMYM4) is one of the six circRNAs validated as up-regulated in HCC (qPCR in SMMC-7721). The study proposes it as a potential diagnostic biomarker, without specifying a downstream ceRNA axis for this circRNA."	0.4032
32355782	Annals of translational medicine	2020	Correlation between the expressions of circular RNAs in peripheral venous blood and clinicopathological features in hepatocellular carcinoma.		circSETD3	hsa_circ_SETD3	SETD3	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"This study reports that circSETD3 is down-regulated in peripheral venous blood of HCC patients versus healthy controls and that low venous circSETD3 is associated with invasive clinicopathological features including MVI. Functional assays in Huh7 cells indicate that circSETD3 suppresses migration and invasion, consistent with a tumor-suppressive role, and the study links circSETD3 to a miR-421-related regulatory axis with predictive value for MVI."	0.6304
32357143	Aging	2020	Hsa_circ_0018818 knockdown suppresses tumorigenesis in non-small cell lung cancer by sponging miR-767-3p.	hsa_circ_0018818		hsa_circ_USP54	USP54	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0018818 is up-regulated in NSCLC and functions as an oncogenic circRNA. Its knockdown suppresses proliferation and invasion and promotes apoptosis, partly by sponging miR-767-3p to regulate NID1 and downstream PI3K/Akt signaling and EMT."	0.697
32366257	Molecular cancer	2020	circNFIB1 inhibits lymphangiogenesis and lymphatic metastasis via the miR-486-5p/PIK3R1/VEGF-C axis in pancreatic cancer.	hsa_circ_0086375		hsa_circ_NFIB	NFIB	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	down-regulated	RT-qPCR; RNA-seq	"circNFIB1 (hsa_circ_0086375), derived from NFIB, is down-regulated in PDAC and inversely associated with lymph node metastasis. It mainly localizes to the cytoplasm and acts as a miR-486-5p sponge to upregulate PIK3R1, inhibit PI3K/AKT signaling, reduce VEGF-C, and thereby suppress lymphangiogenesis and lymphatic metastasis; low circNFIB1 predicts worse patient survival."	0.8886
32366862	Cell death & disease	2020	The circular RNA FAM169A functions as a competitive endogenous RNA and regulates intervertebral disc degeneration by targeting miR-583 and BTRC.	hsa_circ_0007158		hsa_circ_FAM169A	FAM169A	intervertebral disc degeneration 	MONDO:0011385	intervertebral disk degenerative disorder	up-regulated	RT-qPCR; ISH; Microarray	"circ-FAM169A is upregulated in degenerative NP tissues and correlates positively with IDD grade. It promotes disc degeneration by sponging miR-583 to relieve repression of BTRC, leading to activation of NF-kappaB-associated inflammatory and ECM-catabolic programs."	0.8118
32368286	Journal of Cancer	2020	Plasma exo-hsa_circRNA_0056616: A potential biomarker for lymph node metastasis in lung adenocarcinoma.	hsa_circ_0056616				lung adenocarcinoma	MONDO:0005061	lung adenocarcinoma	dysregulated	RT-qPCR	"This study reports exosome-associated hsa_circRNA_0056616 as a plasma biomarker linked to lymph node metastasis status in lung adenocarcinoma, with ROC AUC 0.812. It is also modulated in CXCR4-knockdown LUAD cells/exosomes and shows correlation with CXCR4, but downstream miRNA/mRNA targets were not validated."	0.6238
32368305	Journal of Cancer	2020	circNFIC suppresses breast cancer progression by sponging miR-658.	hsa_circ_0002018		hsa_circ_NFIC	NFIC	breast cancer	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	"circNFIC is down-regulated in breast cancer (especially lung metastatic tissues) and functions as a tumor suppressor. It predominantly localizes to the cytoplasm and acts as a ceRNA by sponging miR-658 to relieve repression of UPK1A, thereby inhibiting proliferation and lung metastasis; low circNFIC is associated with worse survival."	0.7845
32375768	Molecular cancer	2020	Circular RNA circBFAR promotes the progression of pancreatic ductal adenocarcinoma via the miR-34b-5p/MET/Akt axis.	hsa_circ_0009065		hsa_circ_BFAR	BFAR	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circBFAR (hsa_circ_0009065), derived from BFAR, is upregulated in PDAC and promotes proliferation, migration/invasion, tumor growth and metastasis. It acts as a cytoplasmic ceRNA that sponges miR-34b-5p to upregulate MET, thereby activating Akt phosphorylation and MET/PI3K/Akt signaling, and high circBFAR predicts worse OS/DFS."	0.8837
32378344	Journal of cellular and molecular medicine	2020	CircRNA WHSC1 targets the miR-646/NPM1 pathway to promote the development of endometrial cancer.			hsa_circ_WHSC1	WHSC1	endometrial cancer 	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR	"circWHSC1 is up-regulated in endometrial cancer tissues and promotes malignant phenotypes (proliferation, migration, invasion) while inhibiting apoptosis. Mechanistically, it functions as a ceRNA by sponging miR-646, thereby increasing the downstream target NPM1 and enhancing tumor growth in a nude mouse xenograft model."	0.6285
32381016	Molecular cancer	2020	Circular RNA circ_0020710 drives tumor progression and immune evasion by regulating the miR-370-3p/CXCL12 axis in melanoma.	hsa_circ_0020710		hsa_circ_CD151	CD151	melanoma	MONDO:0005105	melanoma	up-regulated	RT-qPCR	"circ_0020710 (CD151-derived) is up-regulated in melanoma and promotes proliferation, migration, invasion and in vivo tumor growth. It acts as a cytoplasmic ceRNA that sponges miR-370-3p to upregulate CXCL12, contributing to malignant progression and an immunosuppressive/CTL-exhausted microenvironment; high circ_0020710 predicts poorer overall survival."	0.8768
32382325	Oncology letters	2020	circ_103809 promotes breast cancer progression by regulating the PI3K/AKT signaling pathway.		hsa_circ_103809			breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_103809 is up-regulated in breast cancer tissues and cell lines. It promotes breast cancer cell proliferation, accelerates cell-cycle progression, inhibits apoptosis, and enhances tumor formation in vivo, at least partly by activating the PI3K/AKT signaling pathway (increased p-AKT and BCL2, decreased Bax upon knockdown reversal)."	0.5442
32386284	Medical science monitor : international medical journal of experimental and clinical research	2020	CircPSMC3 Suppresses Migration and Invasion of Non-Small Cell Lung Cancer Cells via miR-182-5p/NME2 Axis.		CircPSMC3	hsa_circ_PSMC3	PSMC3	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"CircPSMC3 is down-regulated in NSCLC tissues and its low expression is associated with lymph node metastasis and higher TNM stage. Functionally, circPSMC3 suppresses NSCLC cell migration and invasion by sponging miR-182-5p, thereby upregulating NME2."	0.686
32386516	Molecular cancer	2020	Circular RNA circCCDC9 acts as a miR-6792-3p sponge to suppress the progression of gastric cancer through regulating CAV1 expression.	hsa_circ_0000944	circCCDC9	hsa_circ_CCDC9	CCDC9	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; ISH; RNA-seq	"circCCDC9 (hsa_circ_0000944), derived from CCDC9, is down-regulated in gastric cancer and mainly localized in the cytoplasm. It suppresses GC cell proliferation, migration, invasion, tumor growth and liver metastasis by sponging miR-6792-3p and de-repressing CAV1, and higher circCCDC9 expression is associated with better OS/DFS."	0.8892
32392180	Aging	2020	Identification of candidate lncRNAs and circRNAs regulating WNT3/beta-catenin signaling in essential hypertension.	hsa_circ_0039388	cRBL2	hsa_circ_RBL2	RBL2	essential hypertension 	MONDO:0001134	essential hypertension	dysregulated	RNA-seq	"hsa_circ_0039388 (cRBL2), derived from the RBL2 locus, was identified as a differentially expressed circRNA in PBMNCs from essential hypertension patients in the Kazakh cohort and was highlighted by co-expression/ceRNA network analyses as being highly co-expressed with WNT3 and CAMK2N2. No direct functional or mechanistic validation for hsa_circ_0039388 was provided beyond expression profiling and network-based predictions."	0.1768
32392180	Aging	2020	Identification of candidate lncRNAs and circRNAs regulating WNT3/beta-catenin signaling in essential hypertension.	hsa_circ_0038648		hsa_circ_PRKCB	PRKCB	essential hypertension 	MONDO:0001134	essential hypertension	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0038648 (cPRKCB), derived from PRKCB, was validated as differentially expressed in PBMNCs of essential hypertension patients (Kazakh cohort) and is predominantly localized in the cytoplasm of HASMCs. Clinically, it was identified as an independent risk factor for EH and showed diagnostic value by ROC analysis; mechanistically it was linked by co-expression/ceRNA network predictions to WNT3 and CAMK2N2 but was not functionally validated as a regulator in vitro."	0.7329
32393760	Cell death & disease	2020	circ5615 functions as a ceRNA to promote colorectal cancer progression by upregulating TNKS.	hsa_circ_0005615	circ5615	hsa_circ_NFATC3	NFATC3	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circ5615 (hsa_circ_0005615), derived from NFATC3, is upregulated in colorectal cancer and mainly localizes to the cytoplasm. It promotes CRC proliferation/cell-cycle progression and tumor growth by sponging miR-149-5p to de-repress TNKS, thereby activating the Wnt/beta-catenin pathway (e.g., increased nuclear beta-catenin and CCND1). High circ5615 expression correlates with higher T stage and poor overall survival."	0.8991
32393764	Cell death & disease	2020	The circular RNA circMAST1 promotes hepatocellular carcinoma cell proliferation and migration by sponging miR-1299 and regulating CTNND1 expression.	hsa_circ_0049613	hsa_circRNA_102459	hsa_circ_MAST1	MAST1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circMAST1 is up-regulated in hepatocellular carcinoma and acts as an oncogenic circRNA. It promotes proliferation, cell-cycle progression, migration/invasion, and tumor growth by sponging miR-1299 and relieving miR-1299-mediated suppression of CTNND1 (circMAST1/miR-1299/CTNND1 axis)."	0.807
32394619	Journal of cellular and molecular medicine	2020	Genome-Wide Analysis of circular RNAs and validation of hsa_circ_0006719 as a potential novel diagnostic biomarker in congenital scoliosis patients.	hsa_circ_0006719		hsa_circ_VKORC1	VKORC1	Congenital scoliosis 	MONDO:0005392	scoliosis	up-regulated	RT-qPCR; RNA-seq	This study identified hsa_circ_0006719 as up-regulated in peripheral blood of congenital scoliosis patients versus healthy controls and validated it by RT-qPCR. ROC analysis supported its potential as a diagnostic biomarker; mechanistically it was proposed (not proven) to relate to its host gene VKORC1.	0.6841
32395748	Acta biochimica et biophysica Sinica	2020	circStrn3 is involved in bone cancer pain regulation in a rat model.		chr6:72418120|72430205	rno_circ_Strn3	Strn3	Bone cancer pain 	MONDO:0002129	bone cancer	up-regulated	RT-qPCR; RNA-seq	"circStrn3 is up-regulated in a rat bone cancer pain model and was functionally investigated by siRNA knockdown. It may act via a ceRNA mechanism involving rno-miR-9a-5p and Nfkb1, and its knockdown alters apoptosis-related proteins (caspase-3, Bax, Bcl-2) and affects Walker 256 cell apoptosis/proliferation, suggesting biomarker potential for BCP."	0.6619
32395748	Acta biochimica et biophysica Sinica	2020	circStrn3 is involved in bone cancer pain regulation in a rat model.		chr20:7561057|7573740			Bone cancer pain 	MONDO:0002129	bone cancer	up-regulated	RT-qPCR; RNA-seq	"chr20:7561057|7573740 is significantly up-regulated in the BCP rat model versus sham, supported by sequencing and qRT-PCR, and its back-splice junction was confirmed by divergent-primer PCR and Sanger sequencing."	0.5671
32395748	Acta biochimica et biophysica Sinica	2020	circStrn3 is involved in bone cancer pain regulation in a rat model.		chr18:69943105|69944476			Bone cancer pain 	MONDO:0002129	bone cancer	down-regulated	RT-qPCR; RNA-seq	"chr18:69943105|69944476 is significantly down-regulated in the BCP rat model versus sham, supported by sequencing and qRT-PCR, and its back-splice junction was confirmed by divergent-primer PCR and Sanger sequencing."	0.5671
32395748	Acta biochimica et biophysica Sinica	2020	circStrn3 is involved in bone cancer pain regulation in a rat model.		chr5:167516581|167558250			Bone cancer pain 	MONDO:0002129	bone cancer	down-regulated	RT-qPCR; RNA-seq	"chr5:167516581|167558250 is significantly down-regulated in the BCP rat model versus sham, supported by sequencing and qRT-PCR, and its back-splice junction was confirmed by divergent-primer PCR and Sanger sequencing."	0.5671
32398664	Cell death & disease	2020	"CircZNF609 enhances hepatocellular carcinoma cell proliferation, metastasis, and stemness by activating the Hedgehog pathway through the regulation of miR-15a-5p/15b-5p and GLI2 expressions."	hsa_circ_0000615	circZNF609	hsa_circ_ZNF609	ZNF609	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circZNF609 is up-regulated in HCC tissues and cell lines and mainly localizes to the cytoplasm. It promotes proliferation, migration/invasion, EMT and stemness while inhibiting apoptosis by sponging miR-15a-5p/miR-15b-5p, thereby increasing GLI2 expression and activating Hedgehog signaling; knockdown suppresses HCC xenograft growth."	0.852
32398967	Cancer cell international	2020	Hsa_circ_0068307 mediates bladder cancer stem cell-like properties via miR-147/c-Myc axis regulation.	hsa_circ_0068307				bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"hsa_circ_0068307 is up-regulated in bladder cancer tissues/cell lines and promotes proliferation, migration, and stem cell-like properties. Mechanistically, it functions as a ceRNA by sponging miR-147 to increase c-Myc expression, thereby sustaining CSC-related markers; its knockdown suppresses tumor growth in xenografts."	0.6536
32400849	Bioscience reports	2020	Exosomes derived from circRNA Rtn4-modified BMSCs attenuate TNF-alpha-induced cytotoxicity and apoptosis in murine MC3T3-E1 cells by sponging miR-146a.			mmu_circ_Rtn4	RTN4	osteoporosis	MONDO:0005298	osteoporosis	unknown	RT-qPCR	"In a TNF-alpha-induced osteoblast injury model relevant to osteoporosis, exosome-delivered circ-Rtn4 increases intracellular circ-Rtn4 and protects MC3T3-E1 cells by reducing cytotoxicity and apoptosis. Mechanistically, circ-Rtn4 directly binds and sponges miR-146a, lowering miR-146a levels and attenuating apoptosis-associated readouts (e.g., cleaved caspase-3/Bax)."	0.528
32408908	Diagnostic pathology	2020	"Circular RNA KIF4A promotes cell migration, invasion and inhibits apoptosis through miR-152/ZEB1 axis in breast cancer."		circKIF4A	hsa_circ_KIF4A	KIF4A	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circKIF4A is upregulated in breast cancer tissues and cells and promotes migration/invasion while inhibiting apoptosis. Mechanistically, circKIF4A sponges miR-152 to relieve repression of ZEB1, forming a circKIF4A_miR-152_ZEB1 axis that drives malignant phenotypes."	0.6996
32410389	Journal of cellular and molecular medicine	2020	Circular RNA circMDM2 accelerates the glycolysis of oral squamous cell carcinoma by targeting miR-532-3p/HK2.		circMDM2	hsa_circ_MDM2	MDM2	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circMDM2 is up-regulated in OSCC tissues and cell lines and promotes OSCC cell proliferation and glycolysis. It acts as a ceRNA by sponging miR-532-3p to upregulate HK2, and high circMDM2 expression is associated with poor patient survival."	0.8419
32411772	Annals of translational medicine	2020	Comprehensive molecular characterization of circRNA-associated ceRNA network in constrictive pericarditis.	hsa_circ_0008679				constrictive pericarditis 	MONDO:0006711	constrictive pericarditis	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0008679 is up-regulated in constrictive pericarditis pericardial tissues. It is proposed to function as a ceRNA by sponging hsa-miR-656-3p and is linked (by GSEA) to immune/inflammation-related pathways.	0.4032
32411772	Annals of translational medicine	2020	Comprehensive molecular characterization of circRNA-associated ceRNA network in constrictive pericarditis.	hsa_circ_0006238				constrictive pericarditis 	MONDO:0006711	constrictive pericarditis	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0006238 is significantly up-regulated in constrictive pericarditis pericardial tissues. The study¡¯s ceRNA network predicts it sponges hsa-miR-106b-5p to influence downstream gene expression.	0.4032
32411772	Annals of translational medicine	2020	Comprehensive molecular characterization of circRNA-associated ceRNA network in constrictive pericarditis.	hsa_circ_0013093				constrictive pericarditis 	MONDO:0006711	constrictive pericarditis	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0013093 is significantly up-regulated in constrictive pericarditis pericardial tissues. The study¡¯s ceRNA network predicts it sponges hsa-miR-23a-3p to modulate downstream gene expression.	0.4032
32419790	Evidence-based complementary and alternative medicine : eCAM	2020	Analysis of the Molecular Mechanism of Acute Coronary Syndrome Based on circRNA-miRNA Network Regulation.		hsa-circ16316-13	hsa_circ_UTY	UTY	acute coronary syndrome 	MONDO:0005542	acute coronary syndrome	up-regulated	Microarray	"hsa-circ16316-13 (host gene UTY) is up-regulated in peripheral/whole blood from ACS patients (AMI/UAP) versus controls. The study predicts it participates in ACS through circRNA_miRNA network interactions, but provides no targeted functional experiments for this circRNA."	0.1768
32424109	Aging	2020	Overexpression of hsa_circ_0136666 predicts poor prognosis and initiates osteosarcoma tumorigenesis through miR-593-3p/ZEB2 pathway.	hsa_circ_0136666				Osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"hsa_circ_0136666 is upregulated in osteosarcoma and associated with advanced stage and poor prognosis. It promotes proliferation, migration, invasion and tumor growth while inhibiting apoptosis by sponging miR-593-3p to increase ZEB2 expression."	0.7369
32425115	Cell transplantation	2020	CircUBAP2 Inhibits Proliferation and Metastasis of Clear Cell Renal Cell Carcinoma via Targeting miR-148a-3p/FOXK2 Pathway.			hsa_circ_UBAP2	UBAP2	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	down-regulated	RT-qPCR	"circUBAP2 is down-regulated in ccRCC tissues and cell lines. circUBAP2 suppresses ccRCC cell proliferation, migration and invasion, promotes apoptosis and G1 arrest, by sponging miR-148a-3p to regulate the downstream target FOXK2."	0.6536
32425594	Cancer management and research	2020	Circular RNA Circ_0025033 Promotes the Evolvement of Ovarian Cancer Through the Regulation of miR-330-5p/KLK4 Axis.	hsa_circ_0025033	circRNA_0025033			ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circ_0025033 is up-regulated in ovarian cancer and acts as an oncogenic circRNA. It promotes proliferation/viability, migration, invasion, EMT and in vivo tumor growth while suppressing apoptosis by sponging miR-330-5p to increase KLK4 expression."	0.7087
32425596	Cancer management and research	2020	Circular RNA circNRIP1 Sponges microRNA-138-5p to Maintain Hypoxia-Induced Resistance to 5-Fluorouracil Through HIF-1alpha-Dependent Glucose Metabolism in Gastric Carcinoma.	hsa_circ_0004771		hsa_circ_NRIP	NRIP	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circNRIP1 is upregulated in gastric cancer cell lines, further induced by hypoxia, and promotes hypoxia-associated 5-FU chemoresistance. Mechanistically, it sponges miR-138-5p to relieve repression of HIF-1alpha, enhancing HIF-1alpha-dependent glycolysis (increased glucose consumption, lactate and G6P), thereby sustaining drug resistance."	0.5416
32425605	Cancer management and research	2020	Plasmatic circRNA Predicting the Occurrence of Human Glioblastoma.			hsa_circ_FOXO3	FOXO3	glioblastoma 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR	"circFOXO3 is up-regulated in GBM patient plasma and was selected in the validation set as a potential circulating fingerprint for predicting GBM occurrence, contributing to a multi-circRNA diagnostic risk score with high AUC."	0.559
32425605	Cancer management and research	2020	Plasmatic circRNA Predicting the Occurrence of Human Glioblastoma.	hsa_circ_0029426				glioblastoma 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR	circ_0029426 is up-regulated in GBM patient plasma and validated as one of three circulating circRNA fingerprints that can distinguish GBM from controls via a risk-score/ROC diagnostic model.	0.559
32425605	Cancer management and research	2020	Plasmatic circRNA Predicting the Occurrence of Human Glioblastoma.			hsa_circ_SHPRH	SHPRH	glioblastoma 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR	circ-SHPRH is up-regulated in GBM patient plasma and validated as one of three circulating circRNA fingerprints with diagnostic potential for distinguishing GBM from controls using risk score/ROC analysis.	0.559
32425695	Cancer cell international	2020	"Circ_100565 promotes proliferation, migration and invasion in non-small cell lung cancer through upregulating HMGA2 via sponging miR-506-3p."		Circ_100565			non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circ_100565 is up-regulated in NSCLC and mainly localized in the cytoplasm. It promotes NSCLC proliferation, migration, invasion, EMT, and tumor growth by acting as a miRNA sponge for miR-506-3p, thereby relieving repression of HMGA2. High circ_100565 expression is associated with poorer overall survival and more aggressive clinicopathologic features."	0.8279
32426279	Frontiers in oncology	2020	Circular RNA Expression Profiles in Nasopharyngeal Carcinoma by Sequence Analysis.	hsa_circ_0002375		hsa_circ_KITLG	KITLG	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0002375 (circKITLG) is up-regulated in nasopharyngeal carcinoma tissues. Its knockdown suppresses NPC cell proliferation, colony formation, migration, and invasion in vitro. Mechanistically, it is proposed to act as a ceRNA by sponging miR-3198 based on predicted circRNA_miRNA_mRNA networks."	0.6521
32426279	Frontiers in oncology	2020	Circular RNA Expression Profiles in Nasopharyngeal Carcinoma by Sequence Analysis.	hsa_circ_0111974	circESRRG	hsa_circ_ESRRG	ESRRG	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0111974 (circESRRG) is significantly up-regulated in nasopharyngeal carcinoma tissues versus controls, validated by qRT-PCR. No downstream mechanism or functional assays were reported for this circRNA in this study."	0.429
32426279	Frontiers in oncology	2020	Circular RNA Expression Profiles in Nasopharyngeal Carcinoma by Sequence Analysis.	hsa_circ_0081534	circEPHB4	hsa_circ_EPHB4	EPHB4	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0081534 (circEPHB4) is significantly up-regulated in nasopharyngeal carcinoma tissues versus controls, validated by qRT-PCR. This study did not report functional experiments or a specific downstream regulatory axis for this circRNA."	0.429
32426279	Frontiers in oncology	2020	Circular RNA Expression Profiles in Nasopharyngeal Carcinoma by Sequence Analysis.	hsa_circ_0007439	circPPP1CB	hsa_circ_PPP1CB	PPP1CB	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0007439 (circPPP1CB) is significantly down-regulated in nasopharyngeal carcinoma tissues versus controls, validated by qRT-qPCR. No functional assays or mechanistic interactions were reported for this circRNA in this study."	0.429
32426279	Frontiers in oncology	2020	Circular RNA Expression Profiles in Nasopharyngeal Carcinoma by Sequence Analysis.	hsa_circ_0000345	circRSF1	hsa_circ_RSF1	RSF1	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000345 (circRSF1) is significantly down-regulated in nasopharyngeal carcinoma tissues versus controls, validated by qRT-PCR. The study did not provide functional or mechanistic validation for this circRNA beyond differential expression."	0.429
32426279	Frontiers in oncology	2020	Circular RNA Expression Profiles in Nasopharyngeal Carcinoma by Sequence Analysis.	hsa_circ_0138314	circZDHHC21	hsa_circ_ZDHHC21	ZDHHC21	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0138314 (circZDHHC21) is significantly down-regulated in nasopharyngeal carcinoma tissues compared with controls, validated by qRT-qPCR. The study did not test mechanistic interactions or biological functions for this circRNA."	0.429
32430013	Molecular cancer	2020	Circular RNA circMET drives immunosuppression and anti-PD1 therapy resistance in hepatocellular carcinoma via the miR-30-5p/snail/DPP4 axis.	hsa_circ_0082002	circMET	hsa_circ_MET	MET	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH	"circMET (hsa_circ_0082002), derived from MET, is up-regulated in HCC and predicts worse survival and higher recurrence. Functionally, circMET promotes invasion/metastasis and EMT while suppressing antitumor immunity by sponging the miR-30-5p family to increase Snail and downstream DPP4, reducing CXCL10 and CD8+ T-cell infiltration, contributing to anti-PD1 resistance."	0.8283
32430042	Journal of experimental & clinical cancer research : CR	2020	"The circular RNA 001971/miR-29c-3p axis modulates colorectal cancer growth, metastasis, and angiogenesis through VEGFA."		circ-001971			colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ-001971 is up-regulated in colorectal cancer tissues/cell lines and promotes proliferation, invasion/metastasis-related behavior and angiogenesis. Mechanistically, it functions as a ceRNA that binds miR-29c-3p in an AGO2-associated manner, relieving miR-29c-3p-mediated repression of VEGFA; higher circ-001971 correlates with advanced stage and poorer overall survival."	0.8154
32431519	OncoTargets and therapy	2020	Circular RNA circ_0007142 Facilitates Colorectal Cancer Progression by Modulating CDC25A Expression via miR-122-5p.	hsa_circ_0007142		hsa_circ_DOCK1	DOCK1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0007142 is up-regulated in colorectal cancer and promotes malignant phenotypes (proliferation, colony formation, migration/invasion) and xenograft growth. Mechanistically, it functions as a ceRNA sponging miR-122-5p to increase CDC25A expression."	0.6278
32434530	Reproductive biology and endocrinology : RB&E	2020	Downregulation of hsa_circ_0005243 induces trophoblast cell dysfunction and inflammation via the beta-catenin and NF-kappaB pathways.	hsa_circ_0005243		hsa_circ_TMEM184B	TMEM184B	Gestational diabetes mellitus 	MONDO:0005406	gestational diabetes	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005243 is downregulated in GDM placenta and plasma. Its depletion in trophoblast cells impairs proliferation and migration, increases apoptosis and inflammatory cytokine secretion (TNF-alpha, IL-6), and is associated with decreased beta-catenin signaling and increased NF-kappaB p65 nuclear translocation, suggesting diagnostic/therapeutic relevance in GDM."	0.7793
32438315	Molecular therapy. Nucleic acids	2020	Mitochondrial Genome-Derived circRNA mc-COX2 Functions as an Oncogene in Chronic Lymphocytic Leukemia.	hsa_circ_0089762		hsa_circ_COX2	COX2	chronic lymphocytic leukemia 	MONDO:0003864	chronic lymphocytic leukemia/small lymphocytic lymphoma	up-regulated	RT-qPCR; Northern Blot; ISH; Microarray	"mc-COX2 (hsa_circ_0089762), an mt-circRNA derived from mitochondrial COX2, is up-regulated in CLL plasma and enriched in plasma exosomes. mc-COX2 promotes CLL cell viability/proliferation, supports mitochondrial function, and inhibits apoptosis; high mc-COX2 is associated with worse overall survival. Mechanistically, mc-COX2 does not bind AGO2 and may act through non-ceRNA mechanisms; targeting mc-COX2 enhances responses to mitochondrial-related compounds and inhibitors."	0.8478
32440142	OncoTargets and therapy	2020	"Circular RNA circTUBGCP3 Is Up-Regulated and Promotes Cell Proliferation, Migration and Survivability via Sponge _mir-30b in Osteosarcoma."	hsa_circ_0007031	circTUBGCP3	hsa_circ_TUBGCP3	TUBGCP3	Osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"circTUBGCP3 is up-regulated in osteosarcoma tissues and cell lines and functions as an oncogenic circRNA. It predominantly localizes to the cytoplasm and promotes proliferation, migration, survivability and in vivo tumor growth by sponging miR-30b to de-repress Vimentin expression."	0.8351
32440153	OncoTargets and therapy	2020	"Hsa_circ_0043265 Suppresses Proliferation, Metastasis, EMT and Promotes Apoptosis in Non-Small Cell Lung Cancer Through miR-25-3p/FOXP2 Pathway."	hsa_circ_0043265				Non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; ISH	"hsa_circ_0043265 is downregulated in NSCLC tissues/cells and functions as a tumor suppressor. It sponges miR-25-3p to increase FOXP2 expression, thereby inhibiting proliferation, migration/invasion and EMT while promoting apoptosis, and it suppresses xenograft tumor growth."	0.7979
32440159	OncoTargets and therapy	2020	High Expression of hsa_circRNA_001387 in Nasopharyngeal Carcinoma and the Effect on Efficacy of Radiotherapy.	hsa_circ_0001387	hsa_circRNA_001387	hsa_circ_WHSC1	WHSC1	Nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_001387 (hsa_circ_0001387; host gene WHSC1) is up-regulated in nasopharyngeal carcinoma tissues, plasma/blood samples, and NPC cell lines. High expression shows diagnostic value (AUC 0.92) and predicts worse prognosis (shorter OS/PFS) as an independent prognostic factor, and it is associated with radiotherapy response (higher in radioresistant than radiosensitive patients)."	0.6522
32445273	Thoracic cancer	2020	Circ-RNF111 contributes to paclitaxel resistance in breast cancer by elevating E2F3 expression via miR-140-5p.	hsa_circ_0001982	Circ-RNF111	hsa_circ_RNF111	RNF111	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ-RNF111 is upregulated in paclitaxel-resistant breast cancer tissues/cells and promotes PTX resistance, proliferation-related behaviors (viability/colony formation), invasion, and glycolysis. Mechanistically, it sponges miR-140-5p to increase E2F3 expression, enhancing PTX resistance in vitro and in a nude-mouse xenograft model."	0.6825
32445294	Journal of clinical laboratory analysis	2020	The up-regulated hsa-circRNA9102-5 may be a risk factor for essential hypertension.		hsa-circRNA9102-5			essential hypertension 	MONDO:0001134	essential hypertension	up-regulated	RT-qPCR; Microarray	"In peripheral blood from essential hypertension patients, hsa-circRNA9102-5 is significantly up-regulated and is proposed to act as a miRNA sponge for hsa-miR-150-5p. It shows modest diagnostic value alone (AUC 0.620) and improved performance when combined with hsa-miR-150-5p and risk factors (AUC 0.728)."	0.5047
32452125	Journal of cellular and molecular medicine	2020	Identification of circRNA and mRNA expression profiles and functional networks of vascular tissue in lipopolysaccharide-induced sepsis.		rno_circRNA_004806			lipopolysaccharide (LPS)-induced sepsis 	MONDO:0005229	bacterial infectious disease with sepsis	dysregulated	RT-qPCR; Microarray	"rno_circRNA_004806 is a differentially expressed circRNA in aortic tissue from LPS-induced septic rats, validated by RT-qPCR. It was included in predicted CNC and ceRNA networks, implicating it in inflammatory responses and calcium signaling-related regulatory programs during septic vascular injury."	0.5922
32452125	Journal of cellular and molecular medicine	2020	Identification of circRNA and mRNA expression profiles and functional networks of vascular tissue in lipopolysaccharide-induced sepsis.		rno_circRNA_004930			lipopolysaccharide (LPS)-induced sepsis 	MONDO:0005229	bacterial infectious disease with sepsis	dysregulated	RT-qPCR; Microarray	"rno_circRNA_004930 is a differentially expressed circRNA in aortic tissue from LPS-induced septic rats, validated by RT-qPCR. It was analyzed within CNC/ceRNA networks, suggesting potential involvement in inflammatory-response programs and calcium signaling-related regulation during septic vascular injury."	0.5922
32452125	Journal of cellular and molecular medicine	2020	Identification of circRNA and mRNA expression profiles and functional networks of vascular tissue in lipopolysaccharide-induced sepsis.		rno_circRNA_008634			lipopolysaccharide (LPS)-induced sepsis 	MONDO:0005229	bacterial infectious disease with sepsis	dysregulated	RT-qPCR; Microarray	"rno_circRNA_008634 is a RT-qPCR-validated differentially expressed circRNA in aortic tissue in an LPS-induced sepsis rat model. It was used to build predicted CNC/ceRNA networks, implicating it in inflammatory-response and calcium signaling-related regulatory effects in septic vascular injury, though the authors note these are bioinformatic predictions requiring further validation."	0.5922
32452125	Journal of cellular and molecular medicine	2020	Identification of circRNA and mRNA expression profiles and functional networks of vascular tissue in lipopolysaccharide-induced sepsis.		rno_circRNA_008728			lipopolysaccharide (LPS)-induced sepsis 	MONDO:0005229	bacterial infectious disease with sepsis	dysregulated	RT-qPCR; Microarray	"rno_circRNA_008728 is a RT-qPCR-validated differentially expressed circRNA in aortic tissue in an LPS-induced sepsis rat model. It was included in predicted ceRNA and co-expression networks, linking it to inflammatory-response related programs and enrichment of calcium signaling in septic vascular injury."	0.5922
32452125	Journal of cellular and molecular medicine	2020	Identification of circRNA and mRNA expression profiles and functional networks of vascular tissue in lipopolysaccharide-induced sepsis.		rno_circRNA_010219			lipopolysaccharide (LPS)-induced sepsis 	MONDO:0005229	bacterial infectious disease with sepsis	dysregulated	RT-qPCR; Microarray	"rno_circRNA_010219 is a RT-qPCR-validated differentially expressed circRNA in aortic tissue in an LPS-induced sepsis rat model. It was used for CNC and ceRNA network construction, suggesting regulatory involvement in inflammation-related programs and calcium signaling enrichment during septic vascular injury."	0.5922
32452125	Journal of cellular and molecular medicine	2020	Identification of circRNA and mRNA expression profiles and functional networks of vascular tissue in lipopolysaccharide-induced sepsis.		rno_circRNA_016014			lipopolysaccharide (LPS)-induced sepsis 	MONDO:0005229	bacterial infectious disease with sepsis	dysregulated	RT-qPCR; Microarray	"rno_circRNA_016014 is a RT-qPCR-validated differentially expressed circRNA in aortic tissue in an LPS-induced sepsis rat model. It was included in predicted co-expression and ceRNA networks, suggesting possible roles in inflammatory responses and calcium signaling-related regulation in septic vascular injury."	0.5922
32452125	Journal of cellular and molecular medicine	2020	Identification of circRNA and mRNA expression profiles and functional networks of vascular tissue in lipopolysaccharide-induced sepsis.		rno_circRNA_017418			lipopolysaccharide (LPS)-induced sepsis 	MONDO:0005229	bacterial infectious disease with sepsis	dysregulated	RT-qPCR; Microarray	"rno_circRNA_017418 is a RT-qPCR-validated differentially expressed circRNA in aortic tissue in an LPS-induced sepsis rat model. It was one of seven circRNAs used to construct CNC and predicted ceRNA networks, suggesting potential involvement in inflammatory-response programs and calcium signaling-related regulation in septic vascular injury."	0.5922
32453410	Bioscience reports	2020	The regulatory effect of has-circ-0001146/miR-26a-5p/MNAT1 network on the proliferation and invasion of osteosarcoma.	hsa_circ_0001146		hsa_circ_CPNE1	CPNE1	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"In osteosarcoma, hsa-circ-0001146 (from CPNE1) is up-regulated and localizes to both nucleus and cytoplasm. It sponges miR-26a-5p, competitively reducing miR-26a-5p binding to MNAT1 mRNA and increasing MNAT1 expression, thereby promoting proliferation/viability, migration and invasion while reducing apoptosis; knockdown also suppresses xenograft tumor growth."	0.7094
32454461	Aging	2020	"ZNF139/circZNF139 promotes cell proliferation, migration and invasion via activation of PI3K/AKT pathway in bladder cancer."	hsa_circ_0001727	circZNF139	hsa_circ_ZNF139	ZNF139	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circZNF139 (hsa_circ_0001727), derived from ZNF139, is up-regulated in bladder cancer cell lines. Its overexpression promotes proliferation/colony formation, migration and invasion, while knockdown suppresses these phenotypes, and it activates the PI3K/AKT pathway (increased PI3K and p-AKT)."	0.5627
32457332	Cell death & disease	2020	Circular RNA circNRIP1 promotes migration and invasion in cervical cancer by sponging miR-629-3p and regulating the PTP4A1/ERK1/2 pathway.	hsa_circ_0004771	circNRIP1	hsa_circ_NRIP1	NRIP1	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"circNRIP1 (hsa_circ_0004771), derived from NRIP1, is up-regulated in cervical cancer tissues and promotes proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, it is mainly cytoplasmic and acts as a ceRNA by sponging miR-629-3p, thereby increasing PTP4A1 and activating ERK1/2 signaling with downstream changes including MMP2/MMP9 and EMT-related markers."	0.8124
32457613	Frontiers in pharmacology	2020	Circular RNA circKIF4A Sponges miR-375/1231 to Promote Bladder Cancer Progression by Upregulating NOTCH2 Expression.	hsa_circ_0007255	circKIF4A	hsa_circ_KIF4A	KIF4A	bladder cancer	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circKIF4A (hsa_circ_0007255) is up-regulated in bladder cancer tissues and cell lines and promotes proliferation, invasion and metastasis. It mainly localizes to the cytoplasm and functions as a ceRNA sponging miR-375 and miR-1231 to upregulate NOTCH2, with downstream involvement of PI3K/AKT signaling."	0.7302
32460831	Journal of experimental & clinical cancer research : CR	2020	Circ_0008532 promotes bladder cancer progression by regulation of the miR-155-5p/miR-330-5p/MTGR1 axis.	hsa_circ_0008532		hsa_circ_MTGR1	MTGR1	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circ_0008532 is up-regulated in bladder cancer tissues/cell lines and promotes migration, invasion, angiogenesis, and metastasis. Mechanistically, it sponges miR-155-5p and miR-330-5p to increase MTGR1, thereby inhibiting Notch signaling and enhancing bladder cancer aggressiveness."	0.7902
32461970	BioMed research international	2020	Intracranial Infections in Neurological Surgery: The Changes of Circular RNA Expression and Their Possible Function Mechanism.		hsa_circRNA_402632			postoperative central nervous system infection 	MONDO:0024619	central nervous system infectious disorder	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_402632 is up-regulated in infected CSF from patients with postoperative CNS infection after neurological surgery, validated by qRT-PCR in an expanded CSF cohort. Bioinformatics analysis suggested enrichment in the insulin resistance pathway, supporting its potential as a diagnostic biomarker."	0.4032
32461970	BioMed research international	2020	Intracranial Infections in Neurological Surgery: The Changes of Circular RNA Expression and Their Possible Function Mechanism.		hsa_circRNA_008636			postoperative central nervous system infection 	MONDO:0024619	central nervous system infectious disorder	down-regulated	RT-qPCR; Microarray	hsa_circRNA_008636 is down-regulated in infected CSF in postoperative CNS infection and was confirmed by qRT-PCR in an expanded cohort. Bioinformatics analyses suggested involvement of FoxO and AMPK signaling and potential links to oxidative stress/inflammatory response.	0.4032
32461970	BioMed research international	2020	Intracranial Infections in Neurological Surgery: The Changes of Circular RNA Expression and Their Possible Function Mechanism.		hsa_circRNA_405481			postoperative central nervous system infection 	MONDO:0024619	central nervous system infectious disorder	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_405481 is down-regulated in infected CSF in postoperative CNS infection and was confirmed by qRT-PCR in an expanded cohort. Bioinformatics enrichment implicated TGF-beta signaling and other immune/inflammation-related pathways, supporting its potential as a diagnostic biomarker."	0.4032
32462972	Technology in cancer research & treatment	2020	Circular RNA hsa_circ_0000376 Participates in Tumorigenesis of Breast Cancer by Targeting miR-1285-3p.	hsa_circ_0000376				breast cancer	MONDO:0007254	breast cancer	down-regulated	Microarray	"This study identifies hsa_circ_0000376 as a down-regulated circRNA in breast cancer based on the GSE101123 circRNA microarray. Bioinformatic analyses suggest it may function as a ceRNA by sponging miR-1285-3p (and miR-1286), thereby affecting downstream targets such as SMURF1, BTRC, and TP53 and influencing tumorigenesis-related processes including proliferation and metastasis."	0.1768
32463532	Journal of clinical laboratory analysis	2020	Circular RNA_0001742 has potential to predict advanced tumor stage and poor survival profiles in tongue squamous cell carcinoma management.	hsa_circ_0001742				tongue squamous cell carcinoma 	MONDO:0000500	tongue squamous cell carcinoma	up-regulated	RT-qPCR	circ_0001742 is up-regulated in TSCC tumor tissues versus adjacent tissues. High tumor circ_0001742 levels are associated with more advanced T/N/TNM stage and independently predict worse overall survival; it also shows diagnostic discrimination between tumor and adjacent tissue (AUC 0.870).	0.5918
32464601	Aging	2020	Circular RNA hsa_circ_0003141 promotes tumorigenesis of hepatocellular carcinoma via a miR-1827/UBAP2 axis.	hsa_circ_0003141		hsa_circ_UBAP2	UBAP2	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0003141 is up-regulated in hepatocellular carcinoma and acts as an oncogenic circRNA. It promotes proliferation, invasion and EMT and inhibits apoptosis by functioning as a ceRNA that sponges miR-1827 to increase UBAP2 expression, and its knockdown suppresses tumor growth in a Huh-7 xenograft model."	0.697
32467667	Cancer cell international	2020	Circular RNA circ-MAT2B facilitates glycolysis and growth of gastric cancer through regulating the miR-515-5p/HIF-1alpha axis.			hsa_circ_MAT2B	MAT2B	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ-MAT2B is up-regulated in gastric cancer tissues and plasma and promotes GC cell proliferation and glycolysis. It functions mainly in the cytoplasm as a ceRNA that sponges miR-515-5p to increase HIF-1alpha, and HIF-1alpha transcriptionally activates circ-MAT2B to form a positive feedback loop. High circ-MAT2B is associated with aggressive clinicopathological features and poor survival, supporting diagnostic and prognostic value."	0.8246
32467669	Cancer cell international	2020	High expression of ESRP1 regulated by circ-0005585 promotes cell colonization in ovarian cancer.	hsa_circ_0005585	chr5_43704400_43675511__+_28889-NNT	hsa_circ_NNT	NNT	ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; RNA-seq	"In epithelial ovarian cancer, circ-0005585 is up-regulated and functions as a miRNA sponge for miR-23a/b and miR-15a/15b/16, thereby increasing ESRP1 protein expression. Through this ceRNA-like regulation, circ-0005585 supports ESRP1-associated MET/cytoskeletal changes and pro-colonization phenotypes described in the study."	0.7554
32468074	Oncology reports	2020	Circular RNA expression and association with the clinicopathological characteristics in papillary thyroid carcinoma.			hsa_circ_GABRB2	GABRB2	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; RNA-seq	chr5:161330882-161336769- (host gene GABRB2) is up-regulated in PTC and is associated with BRAFV600E mutation. It shows strong diagnostic potential (highest ROC AUC among validated circRNAs) and is predicted to sponge multiple miRNAs.	0.6841
32468074	Oncology reports	2020	Circular RNA expression and association with the clinicopathological characteristics in papillary thyroid carcinoma.			hsa_circ_TMEM132D	TMEM132D	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; RNA-seq	"chr12:129699809-129700698- (host gene TMEM132D) is up-regulated in PTC and correlates with capsular invasion, suggesting relevance to tumor progression. It is predicted to bind several miRNAs (e.g., miR-766-3p) consistent with a putative miRNA-sponge role."	0.6841
32468074	Oncology reports	2020	Circular RNA expression and association with the clinicopathological characteristics in papillary thyroid carcinoma.	hsa_circ_0008796	chr9:22046750-22097364+	hsa_circ_CDKN2B-AS1	CDKN2B-AS1	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0008796 (chr9:22046750-22097364+, host gene CDKN2B-AS1) is up-regulated in PTC and is significantly associated with BRAFV600E mutation. It is predicted to interact with multiple miRNAs, supporting a potential miRNA-sponge role and biomarker utility."	0.6841
32468074	Oncology reports	2020	Circular RNA expression and association with the clinicopathological characteristics in papillary thyroid carcinoma.		chr20:17456347-17465553+			papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; RNA-seq	"chr20:17456347-17465553+ is up-regulated in PTC and was validated by RT-qPCR in paired clinical tissues. It has diagnostic potential by ROC analysis and is predicted to bind multiple miRNAs, suggesting a possible miRNA-sponge role."	0.6841
32468074	Oncology reports	2020	Circular RNA expression and association with the clinicopathological characteristics in papillary thyroid carcinoma.	hsa_circ_0082002	chr7:116699070-116700284+			papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0082002 (chr7:116699070-116700284+) is up-regulated in PTC and validated by RT-qPCR in paired thyroid tissues. It has diagnostic value by ROC analysis and is bioinformatically predicted to interact with several miRNAs.	0.6841
32468074	Oncology reports	2020	Circular RNA expression and association with the clinicopathological characteristics in papillary thyroid carcinoma.	hsa_circ_0002111	chr8:18765448-18804898-	hsa_circ_PSD3	PSD3	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0002111 (chr8:18765448-18804898-, host gene PSD3) is up-regulated in PTC and is significantly associated with BRAFV600E mutation. It is predicted to interact with multiple miRNAs and may serve as a progression-related biomarker."	0.6841
32468074	Oncology reports	2020	Circular RNA expression and association with the clinicopathological characteristics in papillary thyroid carcinoma.		chr7:22308338-22318037-			papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; RNA-seq	"chr7:22308338-22318037- is up-regulated in PTC and validated by RT-qPCR in paired thyroid tissues. It shows diagnostic value in ROC analysis and is predicted to interact with multiple miRNAs, consistent with a potential miRNA-sponge role."	0.6841
32468074	Oncology reports	2020	Circular RNA expression and association with the clinicopathological characteristics in papillary thyroid carcinoma.	hsa_circ_0072309	chr5:38523418-38530666-	hsa_circ_LIFR	LIFR	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0072309 (chr5:38523418-38530666-, host gene LIFR) is down-regulated in PTC. Lower expression is linked to advanced pT stage and lymph node metastasis, suggesting a suppressive association with progression and potential as a progression biomarker; it is predicted to bind miR-409-3p and other miRNAs."	0.6841
32472335	Journal of molecular histology	2020	CircUBAP2 promotes SEMA6D expression to enhance the cisplatin resistance in osteosarcoma through sponging miR-506-3p by activating Wnt/beta-catenin signaling pathway.		circUBAP2	hsa_circ_UBAP2	UBAP2	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circUBAP2 is up-regulated in cisplatin-resistant osteosarcoma tissues/cells and promotes cisplatin resistance and malignant phenotypes. Mechanistically, circUBAP2 sponges miR-506-3p to increase SEMA6D expression and activate Wnt/beta-catenin signaling."	0.6521
32487167	Molecular cancer	2020	Circular RNA circCORO1C promotes laryngeal squamous cell carcinoma progression by modulating the let-7c-5p/PBX3 axis.	hsa_circ_0008714		hsa_circ_CORO1C	CORO1C	laryngeal squamous cell carcinoma 	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circCORO1C is up-regulated in LSCC and mainly localized in the cytoplasm. It promotes LSCC malignant phenotypes (proliferation, migration, invasion, EMT and xenograft growth) by sponging let-7c-5p to derepress PBX3, and its high expression is associated with poor prognosis."	0.8837
32493389	Molecular cancer	2020	Circular RNA circSATB2 promotes progression of non-small cell lung cancer cells.	hsa_circ_0008928		hsa_circ_SATB2	SATB2	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circSATB2 is up-regulated in NSCLC tissues/cells and in serum exosomes from NSCLC patients, and promotes NSCLC proliferation, migration and invasion. Mechanistically, it mainly localizes to the cytoplasm, sponges/negatively regulates miR-326, and thereby upregulates FSCN1; it can also be transferred via exosomes to affect recipient cells. Serum exosomal circSATB2 shows diagnostic potential and correlates with lymphatic metastasis."	0.8399
32493490	Journal of experimental & clinical cancer research : CR	2020	Transcription activation of circ-STAT3 induced by Gli2 promotes the progression of hepatoblastoma via acting as a sponge for miR-29a/b/c-3p to upregulate STAT3/Gli2.	hsa_circ_0043800		hsa_circ_STAT3	STAT3	hepatoblastoma 	MONDO:0018666	hepatoblastoma	up-regulated	RT-qPCR	"circ-STAT3 (Circ_0043800), derived from STAT3, is up-regulated in hepatoblastoma tissues and cell lines and mainly localizes to the cytoplasm. It promotes HB proliferation, migration/invasion, stemness and xenograft tumor growth by acting as a ceRNA that sponges miR-29a/b/c-3p to increase STAT3 and Gli2; Gli2 also transcriptionally activates circ-STAT3, forming a positive regulatory loop."	0.8703
32494004	Scientific reports	2020	CircRNA_101237 promotes NSCLC progression via the miRNA-490-3p/MAPK1 axis.		hsa_circ_101237	hsa_circ_CDK8	CDK8	Non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_101237 is up-regulated in NSCLC tissues and cell lines and mainly localizes to the cytoplasm. It promotes NSCLC cell proliferation, migration and invasion by acting as a ceRNA that sponges miR-490-3p, thereby increasing MAPK1 expression, and high expression is associated with poorer patient survival."	0.8323
32494158	OncoTargets and therapy	2020	Elevated Levels of circRUNX1 in Colorectal Cancer Promote Cell Growth and Metastasis via miR-145-5p/IGF1 Signalling.	hsa_circ_0002360	circRUNX1	hsa_circ_RUNX1	RUNX1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"circRUNX1 (hsa_circ_0002360), derived from RUNX1, is up-regulated in colorectal cancer tissues and correlates with advanced clinical features. It promotes CRC cell proliferation and migration/invasion and metastasis while inhibiting apoptosis, partly by acting as a ceRNA that sponges miR-145-5p to increase IGF1 expression/signaling."	0.7898
32494192	Cancer management and research	2020	Circular RNA _CircPRMT5 Accelerates Proliferation and Invasion of Papillary Thyroid Cancer Through Regulation of miR-30c/E2F3 Axis.		circPRMT5	hsa_circ_PRMT5	PRMT5	papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"CircPRMT5 is up-regulated in papillary thyroid cancer and promotes malignant phenotypes (proliferation, migration, invasion) while suppressing apoptosis. Mechanistically, it functions as a ceRNA that sponges miR-30c, thereby increasing E2F3 expression and driving PTC progression."	0.6996
32495982	Cancer science	2020	"Circular RNA LPAR3 sponges microRNA-198 to facilitate esophageal cancer migration, invasion, and metastasis."	hsa_circ_0006168		hsa_circ_LPAR3	LPAR3	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circLPAR3 is up-regulated in ESCC tissues and cell lines and correlates with lymph node metastasis and advanced TNM stage. It mainly localizes to the cytoplasm and functions as a miR-198 sponge to upregulate MET/c-MET, activating MAPK and PI3K/AKT signaling to promote ESCC migration, invasion, and lung metastasis, without affecting proliferation."	0.8551
32496306	Chinese medical journal	2020	Effect of ciRS-7 expression on clear cell renal cell carcinoma progression.			hsa_circ_CDR1AS		clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR	"ciRS-7 is up-regulated in ccRCC tissues and cell lines and promotes ccRCC cell proliferation and invasion. Mechanistically, ciRS-7 knockdown reduces p-EGFR and p-Akt, suggesting activation of the EGFR/Akt pathway. High ciRS-7 expression correlates with advanced clinicopathological features and shorter progression-free survival."	0.6148
32496549	Bioscience reports	2020	"Silencing circSLAMF6 represses cell glycolysis, migration, and invasion by regulating the miR-204-5p/MYH9 axis in gastric cancer under hypoxia."	hsa_circ_0000144		hsa_circ_SLAMF6	SLAMF6	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circSLAMF6 is up-regulated in gastric cancer (including under hypoxia) and promotes glycolysis, migration, invasion, and tumor growth. Mechanistically, circSLAMF6 sponges miR-204-5p to increase MYH9 expression, forming the circSLAMF6/miR-204-5p/MYH9 axis. High circSLAMF6 expression is associated with shorter overall survival in GC patients."	0.7507
32497020	Aging	2020	The circRNA circIFI30 promotes progression of triple-negative breast cancer and correlates with prognosis.	hsa_circ_0005571	circIFI30	hsa_circ_IFI30	IFI30	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circIFI30 (hsa_circ_0005571), derived from the IFI30 gene, is upregulated in TNBC and mainly localized in the cytoplasm. It promotes TNBC proliferation, migration/invasion, EMT, tumor growth and lung metastasis by sponging miR-520b-3p to upregulate CD44. High circIFI30 is associated with advanced clinicopathological features and poorer overall survival."	0.8969
32499446	Aging	2020	High circ-SEC31A expression predicts unfavorable prognoses in non-small cell lung cancer by regulating the miR-520a-5p/GOT-2 axis.	hsa_circ_0001421	circ-SEC31A	hsa_circ_SEC31A	SEC31A	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circ-SEC31A (hsa_circ_0001421) is upregulated in NSCLC and promotes proliferation, migration, invasion and malate-aspartate metabolism. It functions as a ceRNA by sponging miR-520a-5p to increase GOT2 expression, and high circ-SEC31A indicates poor overall survival."	0.8237
32499818	Frontiers in genetics	2020	CircRNA_103809 Suppresses the Proliferation and Metastasis of Breast Cancer Cells by Sponging MicroRNA-532-3p (miR-532-3p).		circRNA_103809	hsa_circ_ZFR	ZFR	breast cancer	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	"In breast cancer, circRNA_103809 is down-regulated and functions as a tumor suppressor. Its overexpression inhibits proliferation and migration/invasion, induces G2/M arrest, and suppresses EMT, at least partly by sponging miR-532-3p; higher circRNA_103809 expression is associated with better overall survival."	0.7113
32503552	Molecular cancer	2020	CircTLK1 promotes the proliferation and metastasis of renal cell carcinoma by sponging miR-136-5p.	hsa_circ_0004442		hsa_circ_TLK1	TLK1	renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circTLK1 (hsa_circ_0004442), derived from TLK1, is up-regulated in renal cell carcinoma and mainly localized in the cytoplasm. It promotes RCC proliferation, EMT-associated migration/invasion and in vivo tumor growth/metastasis by acting as a ceRNA that sponges miR-136-5p, thereby increasing CBX4 and downstream VEGFA. High circTLK1 expression is associated with distant metastasis and poorer OS/DFS, suggesting prognostic/diagnostic potential."	0.8793
32503653	Journal of ovarian research	2020	Circular RNA hsa_circ_0078607 suppresses ovarian cancer progression by regulating miR-518a-5p/Fas signaling pathway.	hsa_circ_0078607	circ_0078607	hsa_circ_SLC22A3	SLC22A3	ovarian cancer 	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0078607 (circ_0078607), derived from SLC22A3, is down-regulated in ovarian cancer tissues. Its overexpression suppresses ovarian cancer cell proliferation and invasion while promoting apoptosis by sponging miR-518a-5p and thereby increasing Fas expression."	0.6537
32508344	Medical science monitor : international medical journal of experimental and clinical research	2020	Suppression of Circular RNA Hsa_circ_0109320 Attenuates Non-Small Cell Lung Cancer Progression via MiR-595/E2F7 Axis.	hsa_circ_0109320	circ_0109320			non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0109320 is up-regulated in NSCLC tissues and cell lines and is associated with advanced TNM stage/lymph node metastasis and worse overall survival. Functionally, circ_0109320 promotes NSCLC cell proliferation and invasion and inhibits apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-595, thereby increasing E2F7 expression."	0.7878
32508871	Frontiers in genetics	2020	Dysregulation of CircRNA_0001946 Contributes to the Proliferation and Metastasis of Colorectal Cancer Cells by Targeting MicroRNA-135a-5p.	hsa_circ_0001946	CDR1as / CiRS-7	hsa_circ_CDR1	CDR1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0001946 is up-regulated in colorectal cancer tissues and cell lines and its high expression predicts poor overall survival. Functionally, circ_0001946 promotes CRC cell proliferation and metastasis-related behaviors by sponging miR-135a-5p and facilitating EMT-related changes."	0.7126
32509009	Experimental and therapeutic medicine	2020	Microarray and bioinformatics analysis of circular RNAs expression profile in traumatic lung injury.		hsa_circ_102927	hsa_circ_RHBDD1	RHBDD1	traumatic lung injury 	MONDO:0021178	injury	down-regulated	RT-qPCR; Microarray	hsa_circRNA_102927 (host gene RHBDD1) is down-regulated in plasma from traumatic lung injury patients and shows strong diagnostic discrimination by ROC analysis. The study further places it within a predicted ceRNA (circRNA-miRNA-mRNA) network potentially relevant to TLI pathophysiology.	0.5963
32509009	Experimental and therapeutic medicine	2020	Microarray and bioinformatics analysis of circular RNAs expression profile in traumatic lung injury.		hsa_circRNA_100562	hsa_circ_RSU1	RSU1	traumatic lung injury 	MONDO:0021178	injury	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_100562 (host gene RSU1) is down-regulated in plasma from TLI patients, consistent between microarray and RT-qPCR. It is included in a bioinformatically predicted ceRNA network potentially involved in TLI pathogenesis."	0.5135
32509009	Experimental and therapeutic medicine	2020	Microarray and bioinformatics analysis of circular RNAs expression profile in traumatic lung injury.		hsa_circRNA_101523	hsa_circ_TMOD3	TMOD3	traumatic lung injury 	MONDO:0021178	injury	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_101523 (host gene TMOD3) is up-regulated in plasma from TLI patients, consistent between microarray and RT-qPCR. It is incorporated into a predicted ceRNA network suggested to be related to TLI pathogenesis."	0.5135
32509771	Frontiers in cell and developmental biology	2020	Circular RNA hsa_circ_0000848 Promotes Trophoblast Cell Migration and Invasion and Inhibits Cell Apoptosis by Sponging hsa-miR-6768-5p.	hsa_circ_0000848	circ_0000848	hsa_circ_SMAD7	SMAD7	Fetal growth restriction 	MONDO:0005030	fetal growth restriction	down-regulated	RT-qPCR; Microarray	"In FGR placental tissues, hsa_circ_0000848 is down-regulated. Functionally, hsa_circ_0000848 promotes trophoblast (HTR-8) migration/invasion and inhibits apoptosis by sponging hsa-miR-6768-5p, supported by luciferase and AGO2-RIP and rescue experiments."	0.8088
32513952	Cell death & disease	2020	Circ-MMP2 (circ-0039411) induced by FOXM1 promotes the proliferation and migration of lung adenocarcinoma cells in vitro and in vivo.	hsa_circ_0039411		hsa_circ_MMP2	MMP2	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"In LUAD, circ-0039411 (circ-MMP2) is up-regulated and promotes proliferation, migration, EMT, tumor growth and metastasis. FOXM1 transcriptionally activates circ-0039411, and circ-0039411 recruits IGF2BP3 to stabilize FOXM1 mRNA, forming a positive feedback loop that drives malignant progression."	0.8738
32513983	Cell death & disease	2020	Circular RNA circSLC25A16 contributes to the glycolysis of non-small-cell lung cancer through epigenetic modification.	hsa_circ_0018534		hsa_circ_SLC25A16	SLC25A16	non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circSLC25A16 is up-regulated in NSCLC and promotes glycolysis and proliferation. It functions mainly in the cytoplasm as a miRNA sponge for miR-488-3p, thereby increasing HIF-1alpha and enhancing LDHA transcription, which supports tumor growth and is associated with poor prognosis."	0.8701
32513983	Cell death & disease	2020	Circular RNA circSLC25A16 contributes to the glycolysis of non-small-cell lung cancer through epigenetic modification.	hsa_circ_0003459		hsa_circ_SLC25A16	SLC25A16	non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circSLC25A16 is up-regulated in NSCLC and promotes glycolysis and proliferation. It functions mainly in the cytoplasm as a miRNA sponge for miR-488-3p, thereby increasing HIF-1alpha and enhancing LDHA transcription, which supports tumor growth and is associated with poor prognosis."	0.8701
32514012	Cell death & disease	2020	"Increased AT2R expression is induced by AT1R autoantibody via two axes, Klf-5/IRF-1 and circErbB4/miR-29a-5p, to promote VSMC migration."		mmu-circRNA-20314	mmu_circ_ErbB4	ErbB4	AT1-AA-induced vascular remodeling 	MONDO:0005385	vascular disorder	up-regulated	RT-qPCR; Microarray	"In AT1-AA-stimulated vascular smooth muscle cells and in AT1-AA-treated mice, circErbB4 is up-regulated and mainly cytoplasmic. It acts as a sponge for miR-29a-5p, thereby increasing AT2R (Agtr2) protein expression and contributing to VSMC migration associated with vascular remodeling."	0.7657
32514247	Cancer cell international	2020	Circular RNA circ-CSPP1 regulates CCNE2 to facilitate hepatocellular carcinoma cell growth via sponging miR-577.	hsa_circ_0001806	circ-CSPP1	hsa_circ_CSPP1	CSPP1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circ-CSPP1 (hsa_circ_0001806) is upregulated in HCC tissues and cell lines and predicts poorer overall survival. Functionally, it promotes proliferation, colony formation, migration, invasion and xenograft growth. Mechanistically, circ-CSPP1 sponges miR-577 to increase CCNE2 expression, influencing downstream cell-cycle related proteins (e.g., p-Rb/E2F1/c-myc)."	0.8457
32522972	Medical science monitor : international medical journal of experimental and clinical research	2020	Circular RNA (circRNA) CDYL Induces Myocardial Regeneration by ceRNA After Myocardial Infarction.		circCDYL	mmu_circ_CDYL	CDYL	acute myocardial infarction 	MONDO:0004781	acute myocardial infarction	down-regulated	RT-qPCR	"In a mouse myocardial infarction model and hypoxia-treated cardiomyocytes, circCDYL is downregulated. Functional assays show circCDYL promotes cardiomyocyte proliferation and improves post-MI cardiac function by sponging miR-4793-5p to regulate APP."	0.6945
32523351	OncoTargets and therapy	2020	Circ-OXCT1 Suppresses Gastric Cancer EMT and Metastasis by Attenuating TGF-beta Pathway Through the Circ-OXCT1/miR-136/SMAD4 Axis.	hsa_circ_0004873	circ-OXCT1	hsa_circ_OXCT1	OXCT1	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"In gastric cancer, circ-OXCT1 is down-regulated and acts as a tumor suppressor for EMT and metastasis. Mechanistically, it sponges miR-136 in the cytoplasm to modulate SMAD4 and attenuate TGF-beta/Smad-driven EMT marker changes, reducing migration, invasion, and lung metastasis in vivo. Low circ-OXCT1 expression is associated with advanced clinicopathologic features and worse overall survival."	0.8557
32523376	Cancer management and research	2020	Circ_0000517 Contributes to Hepatocellular Carcinoma Progression by Upregulating TXNDC5 via Sponging miR-1296-5p.	hsa_circ_0000517	circ_0000517	hsa_circ_RPPH1	RPPH1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0000517 is up-regulated in HCC tissues and cell lines and mainly localizes to the cytoplasm. It promotes HCC progression by sponging miR-1296-5p to relieve repression of TXNDC5, thereby enhancing proliferation/colony formation and cell-cycle progression and inhibiting apoptosis, with supportive xenograft evidence."	0.7983
32524687	Journal of clinical laboratory analysis	2020	"Implication of hsa_circ_0028007 in reinforcing migration, invasion, and chemo-tolerance of nasopharyngeal carcinoma cells."	hsa_circ_0028007		hsa_circ_NUAK1	NUAK1	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0028007 is up-regulated in nasopharyngeal carcinoma tissues and NPC cell lines. Its high expression is associated with advanced stage, infiltration, lymph-node metastasis and poorer survival. Silencing hsa_circ_0028007 suppresses proliferation/migration/invasion and increases cisplatin/paclitaxel sensitivity, supporting a pro-tumor and pro-chemoresistance role in NPC."	0.6859
32524752	Thoracic cancer	2020	Circ_0072088 promotes the development of non-small cell lung cancer via the miR-377-5p/NOVA2 axis.	hsa_circ_0072088	circ_103809	hsa_circ_ZFR	ZFR	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0072088 is up-regulated in NSCLC tissues and cell lines and promotes malignant phenotypes. Mechanistically, it sponges miR-377-5p to relieve repression of NOVA2, enhancing proliferation and metastatic traits and supporting tumor growth in xenografts."	0.78
32526476	Molecular therapy. Nucleic acids	2020	circCYFIP2 Acts as a Sponge of miR-1205 and Affects the Expression of Its Target Gene E2F1 to Regulate Gastric Cancer Metastasis.	hsa_circ_0003506		hsa_circ_CYFIP2	CYFIP2	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circCYFIP2 (hsa_circ_0003506) is up-regulated in gastric cancer and is associated with metastasis and poorer overall survival. Functionally, it promotes GC cell proliferation, migration/invasion and tumor growth, partly by acting as a ceRNA that sponges miR-1205 to increase E2F1 expression (AGO2-dependent)."	0.8824
32526477	Molecular therapy. Nucleic acids	2020	circFMN2 Sponges miR-1238 to Promote the Expression of LIM-Homeobox Gene 2 in Prostate Cancer Cells.	hsa_circ_0005100		hsa_circ_FMN2	FMN2	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	"circFMN2 (hsa_circ_0005100), derived from FMN2, is up-regulated in prostate cancer tissues and cell lines and shows oncogenic effects. It promotes proliferation, migration/invasion and EMT and inhibits apoptosis, partly via a ceRNA mechanism that sponges miR-1238 to upregulate LHX2; it is also detectable in serum exosomes from PCa patients."	0.8512
32527185	The Journal of international medical research	2020	Bioinformatics analysis of the circRNA-miRNA-mRNA network for non-small cell lung cancer.	hsa_circ_0001947		hsa_circ_AFF2	AFF2	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	Microarray	"This study bioinformatically identified hsa_circ_0001947 as down-regulated in NSCLC tumor tissues versus healthy lung tissues and constructed a putative ceRNA axis hsa_circ_0001947_hsa-miR-637_RRM2. The authors propose this network may contribute to NSCLC development and could be explored as an early diagnostic/therapeutic target, but no experimental functional validation was performed."	0.1768
32527185	The Journal of international medical research	2020	Bioinformatics analysis of the circRNA-miRNA-mRNA network for non-small cell lung cancer.	hsa_circ_0072305		hsa_circ_LIFR	LIFR	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	Microarray	"This study bioinformatically identified hsa_circ_0072305 as down-regulated in NSCLC and highlighted a putative ceRNA axis hsa_circ_0072305_hsa-miR-127-5p_DTL. The authors suggest the network may contribute to NSCLC development and could be a diagnostic/therapeutic target, pending experimental validation."	0.1768
32528231	Cancer cell international	2020	Circular RNA circUBAP2 regulates proliferation and invasion of osteosarcoma cells through miR-641/YAP1 axis.			hsa_circ_UBAP2	UBAP2	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circUBAP2 is up-regulated in osteosarcoma tissues and cell lines. It promotes osteosarcoma cell proliferation, invasion and EMT by acting as a miR-641 sponge, thereby increasing YAP1 expression."	0.7129
32532962	Cell death & disease	2020	Circular RNA circZNF566 promotes hepatocellular carcinoma progression by sponging miR-4738-3p and regulating TDO2 expression.	hsa_circ_0141434		hsa_circ_ZNF566	ZNF566	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circZNF566 is up-regulated in HCC and promotes proliferation, migration, invasion, tumorigenesis and metastasis. It functions mainly as a ceRNA by sponging miR-4738-3p, thereby relieving repression of TDO2 and driving HCC progression; high circZNF566 is associated with poorer survival."	0.8921
32532962	Cell death & disease	2020	Circular RNA circZNF566 promotes hepatocellular carcinoma progression by sponging miR-4738-3p and regulating TDO2 expression.	hsa_circ_0109500		hsa_circ_ZNF566	ZNF566	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circZNF566 is up-regulated in HCC and promotes proliferation, migration, invasion, tumorigenesis and metastasis. It functions mainly as a ceRNA by sponging miR-4738-3p, thereby relieving repression of TDO2 and driving HCC progression; high circZNF566 is associated with poorer survival."	0.8921
32536814	Cancer cell international	2020	Serum-derived three-circRNA signature as a diagnostic biomarker for hepatocellular carcinoma.	hsa_circ_0004001				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0004001 is up-regulated in serum/plasma (blood exosome-associated) samples from HCC patients and shows diagnostic value by ROC analysis. Bioinformatics prediction suggests it may regulate miRNAs and be involved in VEGF/VEGFR, PI3K/Akt/mTOR and Wnt-related signaling."	0.5047
32536814	Cancer cell international	2020	Serum-derived three-circRNA signature as a diagnostic biomarker for hepatocellular carcinoma.	hsa_circ_0004123				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0004123 is up-regulated in serum/plasma (blood exosome-associated) samples from HCC patients and has diagnostic value by ROC analysis. In silico analysis predicts it targets multiple miRNAs and is associated with VEGF/VEGFR, PI3K/Akt/mTOR and Wnt signaling pathways."	0.5047
32536814	Cancer cell international	2020	Serum-derived three-circRNA signature as a diagnostic biomarker for hepatocellular carcinoma.	hsa_circ_0075792				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0075792 is up-regulated in serum/plasma (blood exosome-associated) from HCC patients and can help discriminate HCC from healthy controls by ROC analysis. Bioinformatics prediction links it to miRNA regulation and enrichment in VEGF/VEGFR, PI3K/Akt/mTOR and Wnt signaling."	0.5047
32537647	Bioscience reports	2020	Hsa_circ_0003732 promotes osteosarcoma cells proliferation via miR-545/CCNA2 axis.	hsa_circ_0003732		hsa_circ_HUWE1	HUWE1	Osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0003732 is up-regulated in osteosarcoma tissues/cells and high expression is associated with poorer overall survival. Functionally, it promotes osteosarcoma cell proliferation by sponging miR-545 and thereby increasing CCNA2 expression, affecting cell-cycle progression."	0.7846
32537657	Bioscience reports	2020	Circular RNA FUNDC1 improves prediction of stroke associated infection in acute ischemic stroke patients with high risk.	hsa_circ_0007290		hsa_circ_FUNDC1	FUNDC1	stroke associated infection 	MONDO:0005098	stroke disorder	up-regulated	RT-qPCR	"In plasma from AIS patients, circFUNDC1 is higher in those who develop stroke-associated infection and provides modest predictive value (ROC/AUC) that slightly improves a clinical risk model. circFUNDC1 levels correlate with platelet counts and neutrophil counts, suggesting these cells may contribute to elevated circulating circFUNDC1 in SAI."	0.5339
32541093	Aging	2020	Hsa_circ_0085576 promotes clear cell renal cell carcinoma tumorigenesis and metastasis through the miR-498/YAP1 axis.	hsa_circ_0085576		hsa_circ_ASAP1	ASAP1	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0085576 is up-regulated in ccRCC tissues and cell lines and mainly localizes to the cytoplasm. It promotes ccRCC proliferation, migration/invasion and metastasis while inhibiting apoptosis by sponging miR-498 and derepressing YAP1, activating Hippo/YAP1 signaling; high expression indicates poor prognosis."	0.8802
32547069	OncoTargets and therapy	2020	A Combination of circRNAs as a Diagnostic Tool for Discrimination of Papillary Thyroid Cancer.			hsa_circ_RAPGEF5	RAPGEF5	papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	Serum circRAPGEF5 is up-regulated in PTC versus healthy controls and thyroid nodules and decreases after treatment. It contributes to a two-circRNA panel that improves diagnostic discrimination of PTC and may help monitor disease dynamics.	0.5121
32547069	OncoTargets and therapy	2020	A Combination of circRNAs as a Diagnostic Tool for Discrimination of Papillary Thyroid Cancer.	hsa_circ_0058124				papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	Serum hsa_circ_0058124 is up-regulated in PTC versus healthy controls and thyroid nodules and decreases after treatment. It contributes to a two-circRNA panel that improves diagnostic discrimination of PTC and may help monitor disease dynamics; it is also discussed as a ceRNA affecting NOTCH3/GATAD2A via miRNA-218-5p.	0.5121
32547082	OncoTargets and therapy	2020	Circular RNA Gprc5a Promotes HCC Progression by Activating YAP1/TEAD1 Signalling Pathway by Sponging miR-1283.	hsa_circ_0025508		hsa_circ_GPRC5A	Gprc5a	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circGprc5a is up-regulated in HCC tissues/cell lines and its high level is associated with poorer overall survival. Functionally, circGprc5a promotes HCC cell proliferation and tumor growth while inhibiting apoptosis by sponging miR-1283 and thereby increasing YAP1/TEAD1 expression/activity."	0.8067
32547084	OncoTargets and therapy	2020	Circ_0001023 Promotes Proliferation and Metastasis of Gastric Cancer Cells Thro_ugh _miR-409-3p/PHF10 Axis.	hsa_circ_0001023				gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_0001023 is up-regulated in gastric cancer tissues/cells and promotes malignant phenotypes (proliferation, migration/invasion, tumor growth) while inhibiting apoptosis. Mechanistically, it acts as a ceRNA that sponges miR-409-3p, thereby increasing PHF10 expression (circ_0001023/miR-409-3p/PHF10 axis)."	0.6285
32547085	OncoTargets and therapy	2020	CircHIPK3 Facilitates the G2/M Transition in Prostate Cancer Cells by Sponging miR-338-3p.			hsa_circ_HIPK3	HIPK3	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"CircHIPK3 is upregulated in prostate cancer tissues/cells and promotes proliferation by facilitating the G2/M transition. It functions mainly in the cytoplasm as a ceRNA that sponges miR-338-3p, thereby relieving repression of Cdc25B (and increasing Cdc2), which drives cell-cycle progression."	0.8032
32547106	OncoTargets and therapy	2020	Circular RNA hsa_circ_0131242 Promotes Triple-Negative Breast Cancer Progression by Sponging hsa-miR-2682.	hsa_circ_0131242		hsa_circ_MAP3K4	MAP3K4	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0131242 is up-regulated in TNBC tissues and breast cancer cell lines and promotes malignant phenotypes (proliferation, colony formation, migration). Mechanistically, it functions as a ceRNA by sponging hsa-miR-2682, and high expression is associated with advanced stage and worse overall survival."	0.8343
32547198	Cancer management and research	2020	circRNA MYLK Accelerates Cervical Cancer via Up-Regulation of RHEB and Activation of mTOR Signaling.			hsa_circ_MYLK	MYLK	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circMYLK is up-regulated in cervical cancer cell lines and promotes malignant growth by enhancing proliferation/viability and inhibiting apoptosis. Mechanistically, circMYLK mainly localizes to the cytoplasm and functions as a ceRNA that sponges miR-1301-3p, thereby upregulating RHEB and activating mTOR signaling."	0.7918
32547203	Cancer management and research	2020	Knockdown of circRAD18 Mitigates Breast Cancer Progression through the Regulation of miR-613/HK2 Axis.	hsa_circ_0002453		hsa_circ_RAD18	RAD18	Breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circRAD18 is up-regulated in breast cancer and mainly localizes to the cytoplasm. Functionally, circRAD18 promotes malignant behaviors and tumor growth by acting as a ceRNA that sponges miR-613, thereby increasing HK2 expression and enhancing glycolysis/EMT-related phenotypes."	0.7799
32547227	Cancer management and research	2020	Mechanism of the Regulatory Effect of Overexpression of circMTO1 on Proliferation and Apoptosis of Hepatoma Cells via miR-9-5p/NOX4 Axis.		hsa_circRNA_104135	hsa_circ_MTO1	MTO1	liver cancer 	MONDO:0002691	liver cancer	down-regulated	RT-qPCR; Microarray	"circMTO1 is down-regulated in HCC tissues/cell lines and functions as a tumor suppressor by inhibiting proliferation/migration and promoting apoptosis. Mechanistically, it sponges miR-9-5p to upregulate NOX4, forming a circMTO1/miR-9-5p/NOX4 ceRNA axis."	0.7357
32547228	Cancer management and research	2020	hsa_circ_0008285 Facilitates the Progression of Cervical Cancer by Targeting miR-211-5p/SOX4 Axis.	hsa_circ_0008285		hsa_circ_CDYL	CDYL	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0008285 is up-regulated in cervical cancer tissues and cell lines and acts as an oncogenic circRNA. It promotes CC cell proliferation and invasion and enhances tumor growth by sponging miR-211-5p, thereby relieving repression of SOX4."	0.7855
32547237	Cancer management and research	2020	Upregulation of hsa_circRNA_102958 Indicates Poor Prognosis and Promotes Ovarian Cancer Progression Through miR-1205/SH2D3A Axis.		hsa_circRNA_102958			ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"hsa_circRNA_102958 is up-regulated in ovarian cancer tissues and cell lines and is associated with poor overall survival. It promotes ovarian cancer cell proliferation, migration, and invasion by acting as a ceRNA that sponges miR-1205 and thereby increases SH2D3A expression."	0.7357
32547313	International journal of medical sciences	2020	Circ-APBB1IP as a Prognostic Biomarker Promotes Clear Cell Renal Cell Carcinoma Progression Through The ERK1/2 Signaling Pathway.	hsa_circ_0093390	circ-APBB1IP	hsa_circ_APBB1IP	APBB1IP	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR; Microarray	"circ-APBB1IP (hsa_circ_0093390) is up-regulated in ccRCC tissues and cell lines. Its knockdown inhibits proliferation, migration and invasion while promoting apoptosis, and is associated with reduced p-ERK1/2, indicating promotion of ccRCC progression via ERK1/2 signaling."	0.5821
32547593	Frontiers in genetics	2020	Identification of CircRNA-miRNA-mRNA Regulatory Network in Gastrointestinal Stromal Tumor.		hsa_circRNA_061346	hsa_circ_APP	APP	gastrointestinal stromal tumors 	MONDO:0011719	gastrointestinal stromal tumor	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_061346 is up-regulated in GIST tissues versus adjacent tissues and is included as a hub circRNA in a predicted circRNA_miRNA_mRNA ceRNA network. It shows high diagnostic value by ROC analysis and is positively associated with tumor size, mitotic figure, and malignant degree."	0.5963
32547593	Frontiers in genetics	2020	Identification of CircRNA-miRNA-mRNA Regulatory Network in Gastrointestinal Stromal Tumor.		hsa_circRNA_103114	hsa_circ_APP	APP	gastrointestinal stromal tumors 	MONDO:0011719	gastrointestinal stromal tumor	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_103114 is up-regulated in GIST tissues and is highlighted as a key circRNA within a predicted ceRNA (circRNA_miRNA_mRNA) network. It has high diagnostic performance (ROC) and its higher expression correlates with larger tumor size, higher mitotic figure, and higher malignant degree."	0.5963
32547593	Frontiers in genetics	2020	Identification of CircRNA-miRNA-mRNA Regulatory Network in Gastrointestinal Stromal Tumor.		hsa_circRNA_103870	hsa_circ_SMA4	SMA4	gastrointestinal stromal tumors 	MONDO:0011719	gastrointestinal stromal tumor	up-regulated	RT-qPCR; Microarray	hsa_circRNA_103870 is significantly up-regulated in GIST tissues and is included in a predicted circRNA_miRNA_mRNA regulatory network. It has high diagnostic value (ROC) and correlates positively with tumor size and mitotic figure.	0.5963
32547593	Frontiers in genetics	2020	Identification of CircRNA-miRNA-mRNA Regulatory Network in Gastrointestinal Stromal Tumor.		hsa_circRNA_405324	hsa_circ_STARD9	STARD9	gastrointestinal stromal tumors 	MONDO:0011719	gastrointestinal stromal tumor	down-regulated	RT-qPCR; Microarray	hsa_circRNA_405324 is significantly down-regulated in GIST tissues and is included in a predicted circRNA_miRNA_mRNA regulatory network. It has high diagnostic value (ROC) and lower expression is associated with more aggressive clinicopathologic features.	0.5963
32547593	Frontiers in genetics	2020	Identification of CircRNA-miRNA-mRNA Regulatory Network in Gastrointestinal Stromal Tumor.		hsa_circRNA_406821	hsa_circ_ARMC2	ARMC2	gastrointestinal stromal tumors 	MONDO:0011719	gastrointestinal stromal tumor	down-regulated	RT-qPCR; Microarray	hsa_circRNA_406821 is significantly down-regulated in GIST tissues and is part of a predicted circRNA_miRNA_mRNA network. It has high diagnostic value and its lower expression associates with higher mitotic figure and malignant degree.	0.5963
32547593	Frontiers in genetics	2020	Identification of CircRNA-miRNA-mRNA Regulatory Network in Gastrointestinal Stromal Tumor.		hsa_circRNA_000361	hsa_circ_PLCL2	PLCL2	gastrointestinal stromal tumors 	MONDO:0011719	gastrointestinal stromal tumor	down-regulated	RT-qPCR; Microarray	hsa_circRNA_000361 is significantly down-regulated in GIST tissues and is part of a predicted ceRNA network. It shows high diagnostic value and is inversely associated with mitotic activity.	0.5963
32547599	Frontiers in genetics	2020	Differential Expression and Bioinformatics Analysis of CircRNA in PDGF-BB-Induced Vascular Smooth Muscle Cells.	hsa_circ_0008776	circRNA160	hsa_circ_THSD1	THSD1	atherosclerosis 	MONDO:0005311	atherosclerosis	down-regulated	RNA-seq	"circRNA160 (hsa_circ_0008776), derived from THSD1, is down-regulated in PDGF-BB-induced proliferative/migratory VSMCs and is predicted to act as a miRNA sponge with high network connectivity (multiple miRNA binding sites). Its direct functional impact on VSMC proliferation/migration and any regulation of THSD1 remain unverified in this study."	0.1768
32547599	Frontiers in genetics	2020	Differential Expression and Bioinformatics Analysis of CircRNA in PDGF-BB-Induced Vascular Smooth Muscle Cells.	hsa_circ_0003341	circRNA13360	hsa_circ_GIGYF2	GIGYF2	atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RNA-seq	circRNA13360 (hsa_circ_0003341; host gene GIGYF2) is up-regulated in PDGF-BB-induced VSMCs and is predicted to sponge miR-23b-5p and miR-424-5p within a circRNA_miRNA network. The study provides bioinformatic evidence for a ceRNA role but does not experimentally validate downstream targets or phenotypes for this circRNA.	0.1768
32547599	Frontiers in genetics	2020	Differential Expression and Bioinformatics Analysis of CircRNA in PDGF-BB-Induced Vascular Smooth Muscle Cells.	hsa_circ_0001222	circRNA7637			cardiovascular disease	MONDO:0004995	cardiovascular disorder	unknown	RNA-seq	"circRNA7637 (hsa_circ_0001222) is highlighted as a highly connected node in the constructed circRNA_miRNA network, suggesting potential importance in VSMCs and cardiovascular disease-related biology. However, the paper does not report its expression direction, host gene, specific miRNA partners, or experimental validation for this circRNA."	0.1768
32549788	Cancer cell international	2020	Circ_LDLR promoted the development of papillary thyroid carcinoma via regulating miR-195-5p/LIPH axis.	hsa_circ_0003892	circ_LDLR	hsa_circ_LDLR	LDLR	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circ_LDLR is upregulated in papillary thyroid carcinoma and functions as an oncogenic circRNA. It promotes malignant phenotypes and tumor growth by sponging miR-195-5p, thereby increasing LIPH expression (circ_LDLR/miR-195-5p/LIPH axis)."	0.7799
32549793	Cancer cell international	2020	"Matrine inhibits cell growth, migration, invasion and promotes autophagy in hepatocellular carcinoma by regulation of circ_0027345/miR-345-5p/HOXD3 axis."	hsa_circ_0027345				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"In HCC cells, matrine decreases circ_0027345 expression. circ_0027345 functions as a ceRNA by sponging miR-345-5p, thereby increasing HOXD3 and promoting proliferation, migration/invasion while suppressing apoptosis and autophagy; circ_0027345 overexpression reverses matrine¡¯s anti-tumor effects."	0.5309
32550825	Cancer cell international	2020	Circular RNA circ_0000284 plays an oncogenic role in the progression of non-small cell lung cancer through the miR-377-3p-mediated PD-L1 promotion.	hsa_circ_0000284		hsa_circ_HIPK3	HIPK3	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0000284 (circHIPK3) is up-regulated in NSCLC tissues/cell lines, mainly localized in the cytoplasm, and promotes NSCLC growth and metastatic behaviors. Mechanistically, it functions as a ceRNA to sponge miR-377-3p, thereby relieving repression of PD-L1 and enhancing PD-L1 expression; high circ_0000284 correlates with poorer patient survival."	0.8323
32550900	Theranostics	2020	Stem cell-derived exosomes prevent pyroptosis and repair ischemic muscle injury through a novel exosome/circHIPK3/ FOXO3a pathway.		circHIPK3	hsa_circ_HIPK3	HIPK3	hindlimb ischemia 	MONDO:0005053	ischemic disease	down-regulated	RT-qPCR; RNA-seq	"circHIPK3 is decreased in ischemic hindlimb muscle and can be replenished by UMSC-derived exosomes. Exosomal circHIPK3 sponges miR-421 to increase FOXO3a, thereby inhibiting NLRP3/caspase-1 inflammasome activation, reducing IL-1beta/IL-18 release and pyroptosis, and improving muscle repair and function."	0.7164
32550900	Theranostics	2020	Stem cell-derived exosomes prevent pyroptosis and repair ischemic muscle injury through a novel exosome/circHIPK3/ FOXO3a pathway.		circHIPK3	mmu_circ_Hipk3	Hipk3	hindlimb ischemia 	MONDO:0005053	ischemic disease	down-regulated	RT-qPCR; RNA-seq	"circHIPK3 is decreased in ischemic hindlimb muscle and can be replenished by UMSC-derived exosomes. Exosomal circHIPK3 sponges miR-421 to increase FOXO3a, thereby inhibiting NLRP3/caspase-1 inflammasome activation, reducing IL-1beta/IL-18 release and pyroptosis, and improving muscle repair and function."	0.7164
32552614	Technology in cancer research & treatment	2020	Hsa_Circ_0007841 Enhances Multiple Myeloma Chemotherapy Resistance Through Upregulating ABCG2.	hsa_circ_0007841	circ_0007841	hsa_circ_SEC61A1	SEC61A1	multiple myeloma 	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR	"In doxorubicin-resistant multiple myeloma cell models (U266R and 8226R), hsa_circ_0007841 is up-regulated and promotes chemoresistance. Knockdown of hsa_circ_0007841 reduces IC50 and decreases ABCG2 mRNA/protein, while overexpression increases ABCG2 and resistance; ABCG2 inhibition blocks the resistance phenotype."	0.3957
32552669	BMC genomics	2020	Genome-wide profiling of host-encoded circular RNAs highlights their potential role during the Japanese encephalitis virus-induced neuroinflammatory response.	mmu_circ_0000220				Japanese encephalitis 	MONDO:0019209	Japanese encephalitis	up-regulated	RT-qPCR; RNA-seq	"In JEV-infected mouse brain/microglia, circ_0000220 is up-regulated and promotes neuroinflammatory cytokine production. It functions as a ceRNA by sponging miR-326-3p, thereby influencing miR-326-3p target mRNAs (BCL3, MK2, TRIM25) and the inflammatory response."	0.6144
32552766	Journal of experimental & clinical cancer research : CR	2020	Hsa_circ_0003998 promotes epithelial to mesenchymal transition of hepatocellular carcinoma by sponging miR-143-3p and PCBP1.	hsa_circ_0003998		hsa_circ_ARFGEF2	ARFGEF2	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circ0003998 (hsa_circ_0003998), derived from ARFGEF2, is up-regulated in HCC and PVTT tissues and promotes EMT, migration/invasion, proliferation and metastasis. Mechanistically it sponges miR-143-3p to derepress FOSL2 and also binds the RBP PCBP1 to increase CD44v6 expression, forming circ0003998/miR-143-3p/FOSL2 and circ0003998/PCBP1/CD44v6 axes."	0.8689
32554866	Aging	2020	Silencing of hsa_circ_0101145 reverses the epithelial-mesenchymal transition in hepatocellular carcinoma via regulation of the miR-548c-3p/LAMC2 axis.	hsa_circ_0101145		hsa_circ_DOCK9	DOCK9	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH	"hsa_circ_0101145 is up-regulated in HCC tissues and cell lines and mainly localizes to the cytoplasm. It promotes HCC proliferation, migration/invasion, metastasis and EMT by sponging miR-548c-3p, thereby increasing LAMC2 expression; silencing it suppresses tumor growth and metastasis in vitro and in vivo."	0.7302
32562304	Journal of clinical laboratory analysis	2020	"Hsa_circ_0023642 promotes proliferation, invasion, and migration of gastric cancer by sponging microRNA-223."	hsa_circ_0023642		hsa_circ_UVRAG	UVARG / UVRAG	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; ISH; Microarray	"hsa_circ_0023642 is up-regulated in gastric cancer tissues and cell lines and promotes GC cell proliferation, migration, and invasion. It functions as a ceRNA by sponging miR-223-3p and is linked to regulation of FBXW7, and high expression predicts poorer overall survival."	0.7972
32565953	Oncology letters	2020	Hsa_circ_0038646 promotes cell proliferation and migration in colorectal cancer via miR-331-3p/GRIK3.	hsa_circ_0038646				colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"hsa_circ_0038646 is up-regulated in colorectal cancer tissues and cell lines and promotes CRC cell proliferation and migration. Mechanistically, it sponges miR-331-3p, thereby relieving miR-331-3p-mediated repression of GRIK3 and increasing GRIK3 expression."	0.6369
32576868	Scientific reports	2020	Expression profile and bioinformatics analysis of circular RNAs in acute ischemic stroke in a South Chinese Han population.	hsa_circ_0005548		hsa_circ_AMBRA1	AMBRA1	acute ischemic stroke 	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0005548 is up-regulated in circulating blood of AIS patients versus controls and was validated by RT-qPCR. Its diagnostic performance was weak (AUC 0.51) in this cohort.	0.5047
32576868	Scientific reports	2020	Expression profile and bioinformatics analysis of circular RNAs in acute ischemic stroke in a South Chinese Han population.	hsa_circ_0000607	hsa_circRNA_0000607	hsa_circ_VPS13C	VPS13C	acute ischemic stroke 	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000607 is significantly down-regulated in AIS circulating blood and was validated by RT-qPCR in 32 AIS vs 32 controls. Bioinformatic predictions suggest it may act as a miRNA sponge for miR-337-3p and regulate the miR-337-3p/Bcl2 axis, potentially linking it to apoptosis-related processes in AIS; ROC analysis (AUC 0.75) supports diagnostic potential."	0.5047
32576868	Scientific reports	2020	Expression profile and bioinformatics analysis of circular RNAs in acute ischemic stroke in a South Chinese Han population.	hsa_circ_0002465		hsa_circ_CD109	CD109	acute ischemic stroke 	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0002465 is significantly down-regulated in AIS circulating blood and was validated by RT-qPCR in 32 AIS vs 32 controls. ROC analysis (AUC 0.69) suggests it may help distinguish AIS patients from healthy controls, supporting potential diagnostic biomarker value."	0.4679
32581550	OncoTargets and therapy	2020	CircRNA-PTN Sponges miR-326 to Promote Proliferation in Hepatocellular Carcinoma.			hsa_circ_PTN	PTN	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circPTN is up-regulated in HCC tumor tissues and HCC cell lines and promotes HCC cell proliferation. Mechanistically, it localizes mainly in the cytoplasm and functions as a ceRNA by sponging miR-326, thereby increasing ErbB and PI3K expression and enhancing tumor growth-related proliferation. It is proposed as a potential diagnostic biomarker and therapeutic target in HCC."	0.8173
32581651	Cancer cell international	2020	CircRNA DONSON contributes to cisplatin resistance in gastric cancer cells by regulating miR-802/BMI1 axis.			hsa_circ_DONSON	DONSON	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circDONSON is up-regulated in gastric cancer, especially in cisplatin (DDP)-resistant tissues/cells. It promotes cisplatin resistance by sponging miR-802 and thereby increasing BMI1 expression, leading to enhanced proliferation/viability and reduced apoptosis under DDP treatment."	0.7412
32582119	Frontiers in microbiology	2020	A Panel of CircRNAs in the Serum Serves as Biomarkers for Mycobacterium tuberculosis Infection.		hsa_circRNA_051239	hsa_circ_ATP5SL	ATP5SL	tuberculosis 	MONDO:0018076	tuberculosis	up-regulated	RT-qPCR; Microarray	circRNA_051239 is significantly increased in serum of active TB patients and shows strong diagnostic performance by ROC analysis. It is also higher in drug-resistant TB than drug-susceptible cases and is hypothesized to act as a ceRNA sponging miR-320a in drug resistance.	0.5047
32582119	Frontiers in microbiology	2020	A Panel of CircRNAs in the Serum Serves as Biomarkers for Mycobacterium tuberculosis Infection.		hsa_circRNA_029965	hsa_circ_PDS5B	PDS5B	tuberculosis 	MONDO:0018076	tuberculosis	up-regulated	RT-qPCR; Microarray	circRNA_029965 is up-regulated in serum from active TB patients versus controls and has diagnostic value based on ROC analysis.	0.4679
32582119	Frontiers in microbiology	2020	A Panel of CircRNAs in the Serum Serves as Biomarkers for Mycobacterium tuberculosis Infection.		hsa_circRNA_404022	hsa_circ_AGPAT6	AGPAT6	tuberculosis 	MONDO:0018076	tuberculosis	up-regulated	RT-qPCR; Microarray	circRNA_404022 is up-regulated in serum from active TB patients versus controls and has diagnostic value based on ROC analysis.	0.4679
32582276	Frontiers in genetics	2020	Analysis of Circular RNA-Related Competing Endogenous RNA Identifies the Immune-Related Risk Signature for Colorectal Cancer.	hsa_circ_0035445				colorectal cancer 	MONDO:0005575	colorectal cancer	unknown	Microarray	hsa_circ_0035445 was identified as a key differentially expressed circRNA in colorectal cancer and included in a predicted circRNA_miRNA_mRNA ceRNA hub subnetwork. Its role and direction of effect in CRC were not experimentally validated and were proposed based on bioinformatics.	0.1768
32582276	Frontiers in genetics	2020	Analysis of Circular RNA-Related Competing Endogenous RNA Identifies the Immune-Related Risk Signature for Colorectal Cancer.	hsa_circ_0001666				colorectal cancer 	MONDO:0005575	colorectal cancer	unknown	Microarray	hsa_circ_0001666 was included among five key circRNAs in a predicted CRC ceRNA hub subnetwork derived from public datasets. The study did not provide experimental validation or a defined functional role in CRC beyond the bioinformatics-based ceRNA hypothesis.	0.1768
32582276	Frontiers in genetics	2020	Analysis of Circular RNA-Related Competing Endogenous RNA Identifies the Immune-Related Risk Signature for Colorectal Cancer.	hsa_circ_0000375				colorectal cancer 	MONDO:0005575	colorectal cancer	unknown	Microarray	hsa_circ_0000375 was selected as one of five crucial circRNAs in a CRC-related ceRNA hub subnetwork built from GEO/TCGA-derived differential expression and interaction predictions. No experimental functional validation in CRC was provided.	0.1768
32582276	Frontiers in genetics	2020	Analysis of Circular RNA-Related Competing Endogenous RNA Identifies the Immune-Related Risk Signature for Colorectal Cancer.	hsa_circ_0003600				colorectal cancer 	MONDO:0005575	colorectal cancer	unknown	Microarray	hsa_circ_0003600 was highlighted as one of five crucial circRNAs in a CRC-related circRNA_miRNA_mRNA ceRNA hub subnetwork. The association was derived from microarray and bioinformatics analyses without experimental validation.	0.1768
32582276	Frontiers in genetics	2020	Analysis of Circular RNA-Related Competing Endogenous RNA Identifies the Immune-Related Risk Signature for Colorectal Cancer.	hsa_circ_0000512				colorectal cancer 	MONDO:0005575	colorectal cancer	unknown	Microarray	"hsa_circ_0000512 was identified via differential expression and included as a key node in a predicted CRC ceRNA hub subnetwork linking circRNAs, miRNAs, and hub genes. The study notes that these circRNAs have not been reported in CRC previously and require future experimental verification."	0.1768
32584784	Aging	2020	hsa_circ_0004018 suppresses the progression of liver fibrosis through regulating the hsa-miR-660-3p/TEP1 axis.	hsa_circ_0004018				liver fibrosis 	MONDO:0100430	fibrotic liver disease	down-regulated	RT-qPCR	hsa_circ_0004018 is down-regulated during liver fibrogenesis. Its overexpression suppresses hepatic stellate cell proliferation and activation and alleviates CCl4-induced liver fibrosis by sponging hsa-miR-660-3p and de-repressing TEP1.	0.705
32587240	Cell death & disease	2020	Circular RNA circ_0111277 attenuates human trophoblast cell invasion and migration by regulating miR-494/HTRA1/Notch-1 signal pathway in pre-eclampsia.	hsa_circ_0111277		hsa_circ_PAPPA2	PAPPA2	pre-eclampsia 	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR	"hsa_circ_0111277 (circPAPPA2) is up-regulated in pre-eclampsia placentas and correlates positively with proteinuria and placental weight. It mainly localizes to the cytoplasm and inhibits trophoblast migration/invasion by acting as a sponge for miR-494-3p, thereby regulating HTRA1 and downstream Notch-1 signaling."	0.7759
32587447	World journal of gastroenterology	2020	Hsa_circRNA_102610 upregulation in Crohn's disease promotes transforming growth factor-beta1-induced epithelial-mesenchymal transition via sponging of hsa-miR-130a-3p.		hsa_circRNA_102610			Crohn¡¯s disease 	MONDO:0005011	Crohn disease	up-regulated	RT-qPCR	"In Crohn¡¯s disease, hsa_circRNA_102610 is up-regulated and promotes intestinal epithelial cell proliferation and TGF-beta1-induced EMT. Mechanistically, it directly binds (sponges) hsa-miR-130a-3p, leading to increased SMAD4 and CyclinD1 and EMT marker changes (¡üVimentin/¡üN-cadherin/¡ýE-cadherin)."	0.6815
32592222	Journal of cellular and molecular medicine	2020	"Involvement of a novel circularRNA, hsa_circ_0000520, attenuates tumorigenesis of cervical cancer cell through competitively binding with miR-146b-3p."	hsa_circ_0000520				cervical cancer 	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0000520 (circ_0000520) is down-regulated in cervical cancer and functions as a tumor suppressor. It sponges miR-146b-3p, thereby relieving miR-146b-3p-mediated repression of PAX5 and inhibiting CC cell growth, migration/invasion, while promoting apoptosis and suppressing xenograft tumor growth."	0.7017
32593303	Molecular cancer	2020	Cancer cell-derived exosomal circUHRF1 induces natural killer cell exhaustion and may cause resistance to anti-PD1 therapy in hepatocellular carcinoma.	hsa_circ_0048677	circular ubiquitin-like with PHD and ring finger domain 1 RNA (circUHRF1)	hsa_circ_UHRF1	UHRF1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circUHRF1 (hsa_circ_0048677), derived from UHRF1, is up-regulated in HCC tissues and enriched in HCC-cell-derived exosomes. It is transferred to NK cells and functions as a ceRNA to sequester/degrade miR-449c-5p, thereby increasing TIM-3 expression, inducing NK cell exhaustion, promoting immune evasion, and contributing to anti-PD1 therapy resistance."	0.8681
32596283	BioMed research international	2020	Expression Profiles and Ontology Analysis of Circular RNAs in a Mouse Model of Myocardial Ischemia/Reperfusion Injury.	mmu_circ_0001379	mmu_circRNA_0001379	mmu_circ_Zfp644	Zfp644	myocardial ischemia	MONDO:0024644	myocardial ischemia	up-regulated	RT-qPCR; RNA-seq	"mmu_circRNA_0001379 is up-regulated in mouse myocardial I/R injury and was confirmed by RT-qPCR. It is predicted to act as a miRNA sponge (notably miR-17-5p), potentially influencing downstream targets related to cardiomyocyte injury/apoptosis."	0.3684
32596283	BioMed research international	2020	Expression Profiles and Ontology Analysis of Circular RNAs in a Mouse Model of Myocardial Ischemia/Reperfusion Injury.	mmu_circ_0002263		mmu_circ_Ascc3	Ascc3	myocardial ischemia	MONDO:0024644	myocardial ischemia	down-regulated	RT-qPCR; RNA-seq	"novel_circ_0002263 (also referred to as mmu_circRNA_0002263) is down-regulated in mouse myocardial I/R injury and was confirmed by RT-qPCR. Its potential interacting miRNAs were predicted (e.g., miR-145a-5p/miR-145b/miR-669p-5p), suggesting a possible miRNA-sponge role, but downstream targets/functions were not experimentally established."	0.3684
32596384	BioMed research international	2020	CircEIF4G2 Promotes Tumorigenesis and Progression of Osteosarcoma by Sponging miR-218.		circEIF4G2	hsa_circ_EIF4G2	EIF4G2	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circEIF4G2 is up-regulated in osteosarcoma tissues and cell lines and functions as an oncogenic circRNA. Its knockdown suppresses proliferation, migration, and invasion. Mechanistically, circEIF4G2 directly binds (sponges) miR-218, and miR-218 mediates the effects of circEIF4G2 on OS progression."	0.6369
32597022	Journal of cellular and molecular medicine	2020	Circ-AKT3 inhibits the accumulation of extracellular matrix of mesangial cells in diabetic nephropathy via modulating miR-296-3p/E-cadherin signals.		circ_AKT3	mmu_circ_AKT3	AKT3	diabetic nephropathy	MONDO:0005016	diabetic kidney disease	down-regulated	RT-qPCR	"In db/db diabetic nephropathy mice and high-glucose_treated SV40-MES13 mesangial cells, circ-AKT3 is down-regulated. Its overexpression suppresses extracellular matrix (FN, Col. I, Col. IV) accumulation and reduces apoptosis by sponging miR-296-3p and thereby upregulating E-cadherin."	0.7164
32600329	Molecular cancer	2020	Exosomal circSHKBP1 promotes gastric cancer progression via regulating the miR-582-3p/HUR/VEGF axis and suppressing HSP90 degradation.	hsa_circ_0000936	circSHKBP1	hsa_circ_SHKBP1	SHKBP1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circSHKBP1 (hsa_circ_0000936) is up-regulated in gastric cancer tissues and serum exosomes and is associated with advanced TNM stage and poor survival. Functionally, it promotes GC cell proliferation, migration, invasion, angiogenesis, tumor growth and metastasis. Mechanistically, it sponges miR-582-3p to increase HUR and stabilize/raise VEGF, and it also binds HSP90 to block STUB1-mediated ubiquitination, reducing HSP90 degradation; exosomal circSHKBP1 supports intercellular communication and is proposed as a circulating biomarker."	0.8846
32600379	Journal of experimental & clinical cancer research : CR	2020	SRSF10 inhibits biogenesis of circ-ATXN1 to regulate glioma angiogenesis via miR-526b-3p/MMP2 pathway.		circ-ATXN1 	hsa_circ_ATXN1	ATXN1	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; Microarray	"circ-ATXN1 is up-regulated in glioma-associated endothelial cells and promotes angiogenesis-related behaviors (viability, migration, tube formation). Mechanistically, SRSF10 promotes circ-ATXN1 biogenesis, and circ-ATXN1 sponges miR-526b-3p in Ago2/RISC to increase MMP2/VEGFA and enhance angiogenesis."	0.7763
32602212	Thoracic cancer	2020	circ_0007385 served as competing endogenous RNA for miR-519d-3p to suppress malignant behaviors and cisplatin resistance of non-small cell lung cancer cells.	hsa_circ_0007385	circ_0007385	hsa_circ_MEMO1	MEMO1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"In NSCLC, circ_0007385 is upregulated and associated with poorer overall survival. Functionally, circ_0007385 promotes malignant behaviors and cisplatin resistance by acting as a ceRNA that sponges miR-519d-3p to upregulate HMGB1, and its knockdown suppresses tumor growth in a xenograft model."	0.6912
32606648	International journal of chronic obstructive pulmonary disease	2020	Identification and Bioinformatic Analysis of Circular RNA Expression in Peripheral Blood Mononuclear Cells from Patients with Chronic Obstructive Pulmonary Disease.	hsa_circ_0008672				chronic obstructive pulmonary disease 	MONDO:0005002	chronic obstructive pulmonary disease	dysregulated	Microarray	"This study identified hsa_circRNA_0008672 as a key dysregulated circRNA in PBMCs from COPD patients. Bioinformatic ceRNA analyses suggest it may sponge miR-1265 to influence MAPK1, linking it to immune/inflammatory pathways relevant to COPD pathogenesis."	0.1768
32606648	International journal of chronic obstructive pulmonary disease	2020	Identification and Bioinformatic Analysis of Circular RNA Expression in Peripheral Blood Mononuclear Cells from Patients with Chronic Obstructive Pulmonary Disease.	hsa_circ_0000074				chronic obstructive pulmonary disease 	MONDO:0005002	chronic obstructive pulmonary disease	down-regulated	RT-qPCR; Microarray	"Hsa_circ_0000074 was significantly down-regulated in PBMCs from COPD patients versus controls and was validated by RT-qPCR, supporting its association with COPD."	0.3588
32606732	OncoTargets and therapy	2020	CircFoxo3 Promotes Adriamycin Resistance Through Regulation of miR-199a-5p/ATP Binding Cassette Subfamily C Member 1 Axis in Hepatocellular Carcinoma.		circFoxo3 	hsa_circ_FOXO3	FOXO3	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circFoxo3 is up-regulated in HCC, particularly in ADM-resistant and metastatic tissues/cell lines, and high expression correlates with worse patient survival. Functionally, circFoxo3 promotes invasion and tumor growth and contributes to adriamycin resistance by sponging miR-199a-5p, thereby increasing ABCC1 and promoting EMT."	0.8432
32606734	OncoTargets and therapy	2020	Elevation in the Expression of circ_0079586 Predicts Poor Prognosis and Accelerates Progression in Glioma via Interactions with the miR-183-5p/MDM4 Signaling Pathway.	hsa_circ_0079586	circ_0079586	hsa_circ_IGF2BP3	IGF2BP3	Glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ_0079586 is up-regulated in glioma tissues and cell lines and is associated with more severe clinicopathological features and poorer overall survival. Functionally, it promotes proliferation/growth, migration and invasion while inhibiting apoptosis, mainly by acting as a cytoplasmic miR-183-5p sponge to increase MDM4 expression."	0.7369
32606737	OncoTargets and therapy	2020	CircNOL10 Acts as a Sponge of miR-135a/b-5p in Suppressing Colorectal Cancer Progression via Regulating KLF9.	hsa_circ_0000977	CircNOL10	hsa_circ_NOL10	NOL10	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	"CircNOL10 is down-regulated in colorectal cancer and higher expression correlates with longer survival. Functionally, circNOL10 suppresses CRC cell proliferation, cell-cycle progression, migration and invasion, and inhibits xenograft tumor growth by sponging miR-135a-5p/miR-135b-5p to relieve repression of KLF9."	0.8324
32606748	OncoTargets and therapy	2020	A Novel Serum Exosomes-Based Biomarker hsa_circ_0002130 Facilitates Osimertinib-Resistance in Non-Small Cell Lung Cancer by Sponging miR-498.	hsa_circ_0002130	hsa_circRNA_0002130	hsa_circ_C3	C3	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0002130 is upregulated in osimertinib-resistant NSCLC cells and in serum exosomes from resistant patients. It promotes resistance by acting as a ceRNA that sponges miR-498, thereby increasing GLUT1/HK2/LDHA expression and enhancing glycolysis, cell viability, and tumor growth while suppressing apoptosis."	0.8432
32606768	OncoTargets and therapy	2020	"Hsa_circRNA_000166 Promotes Cell Proliferation, Migration and Invasion by Regulating miR-330-5p/ELK1 in Colon Cancer."		hsa_circRNA_000166 			colon cancer 	MONDO:0021063	malignant colon neoplasm	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_000166 is up-regulated in colon cancer tissues and cell lines. It promotes colon cancer cell proliferation, migration, and invasion and enhances xenograft tumor growth by sponging miR-330-5p, thereby relieving miR-330-5p-mediated repression of ELK1."	0.7795
32606783	OncoTargets and therapy	2020	Diagnostic Role of Dysregulated Circular RNA hsa_circ_0036722 in Laryngeal Squamous Cell Carcinoma.	hsa_circ_0036722		hsa_circ_RHCG	RHCG	laryngeal squamous cell carcinoma 	MONDO:0005595	laryngeal squamous cell carcinoma	down-regulated	RT-qPCR	"hsa_circ_0036722 is down-regulated in LSCC tissues and functions as a tumor suppressor. It sponges miR-1248 to relieve repression of RHCG, thereby inhibiting LSCC cell proliferation, and shows diagnostic potential (ROC AUC ~0.84)."	0.7936
32606803	OncoTargets and therapy	2020	Circ-PRKDC Contributes to 5-Fluorouracil Resistance of Colorectal Cancer Cells by Regulating miR-375/FOXM1 Axis and Wnt/beta-Catenin Pathway.	hsa_circ_0136666	circ-PRKDC 	hsa_circ_PRKDC	PRKDC	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ-PRKDC (circ_0136666) is up-regulated in 5-FU-resistant colorectal cancer tissues and cells and promotes 5-FU chemoresistance. Mechanistically, it sponges miR-375 to increase FOXM1 and activates Wnt/beta-catenin signaling (beta-catenin, c-Myc), enhancing colony formation and invasion; its knockdown sensitizes tumors to 5-FU in a xenograft model."	0.7412
32606970	Cancer management and research	2020	The Regulatory Role of circRNA_101308 in Cervical Cancer and the Prediction of Its Mechanism.		circRNA_101308	hsa_circ_TMCO3	TMCO3	cervical cancer 	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR	"circRNA_101308 (from TMCO3) is down-regulated in cervical cancer tissues and acts as a tumor suppressor by inhibiting proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, it sponges multiple miRNAs (miR-26a-5p, miR-196a-5p, miR-196b-5p, miR-335-3p, miR-1307-3p), with downstream pathways predicted by GO/KEGG enrichment."	0.6815
32606978	Cancer management and research	2020	CircRNA SMARCC1 Sponges MiR-140-3p to Regulate Cell Progression in Colorectal Cancer.	hsa_circ_0003602	circSMARCC1 	hsa_circ_SMARCC1	SMARCC1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circSMARCC1 is up-regulated in colorectal cancer tissues/cell lines and promotes proliferation, migration and invasion. Mechanistically, it sponges miR-140-3p and regulates MMP-related markers (MMP-2/MMP-9) and VEGF, forming a circSMARCC1/miR-140-3p/MMPs axis with potential biomarker/therapeutic relevance."	0.8119
32608539	Journal of clinical laboratory analysis	2020	CircHN1 affects cell proliferation and migration in gastric cancer.	hsa_circ_0045602	circHN1	hsa_circ_HN1	HN1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circHN1 (hsa_circ_0045602), derived from the HN1 gene, is up-regulated in gastric cancer tissues and cell lines. Functionally, circHN1 suppresses GC cell proliferation, migration, and invasion in vitro and inhibits xenograft tumor growth in vivo. Mechanistically, circHN1 is mainly cytoplasmic, binds AGO2, and acts as a miRNA sponge for miR-1248 and miR-375."	0.822
32612388	Cancer management and research	2020	Lidocaine Suppresses Cell Proliferation and Aerobic Glycolysis by Regulating circHOMER1/miR-138-5p/HEY1 Axis in Colorectal Cancer.			hsa_circ_HOMER1	HOMER1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circHOMER1 is up-regulated in colorectal cancer tissues and cell lines. It promotes malignant phenotypes by sponging miR-138-5p to increase HEY1 expression, thereby supporting proliferation and aerobic glycolysis and reducing apoptosis; lidocaine counteracts CRC partly by down-regulating circHOMER1 and modulating the circHOMER1/miR-138-5p/HEY1 axis."	0.6521
32612392	Cancer management and research	2020	Circular RNA FOXO3 Suppresses Bladder Cancer Progression and Metastasis by Regulating MiR-9-5p/TGFBR2.		circ-FOXO3 	hsa_circ_FOXO3	Foxo3	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"circ-FOXO3 is down-regulated in bladder cancer tissues and functions as a tumor suppressor. It inhibits bladder cancer cell proliferation, migration and invasion by sponging miR-9-5p and regulating TGFBR2. Low circ-FOXO3 expression is associated with poorer patient survival, suggesting prognostic potential."	0.7325
32612946	Frontiers in oncology	2020	CircCSPP1 Functions as a ceRNA to Promote Colorectal Carcinoma Cell EMT and Liver Metastasis by Upregulating COL1A1.	hsa_circ_0001806	circCSPP1 	hsa_circ_CSPP1	CSPP1	colorectal carcinoma 	MONDO:0024331	colorectal carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"circCSPP1 (hsa_circ_0001806) is up-regulated in colorectal carcinoma and promotes EMT, migration/invasion, and liver metastasis. It acts as a ceRNA by sponging miR-193a-5p to relieve repression of COL1A1, increasing COL1A1 expression and EMT marker changes. High circCSPP1 is associated with higher M stage and worse overall survival in the patient cohort."	0.8734
32614785	Aging	2020	"circMET promotes NSCLC cell proliferation, metastasis, and immune evasion by regulating the miR-145-5p/CXCL3 axis."	hsa_circ_0082003	circMET 	hsa_circ_MET	MET	non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circMET is up-regulated in NSCLC tissues and promotes malignant phenotypes (proliferation, migration/invasion/metastasis) and immune evasion. It functions mainly as a ceRNA by sponging miR-145-5p to relieve repression of CXCL3, and high circMET predicts worse OS/PFS."	0.861
32614786	Aging	2020	"CircFOXO3 rs12196996, a polymorphism at the gene flanking intron, is associated with circFOXO3 levels and the risk of coronary artery disease."	hsa_circ_0006404	CircFOXO3 	hsa_circ_FOXO3	FOXO3	coronary artery disease 	MONDO:0005010	coronary artery disorder	down-regulated	RT-qPCR	"This study links the flanking-intron SNP rs12196996 to reduced circFOXO3 expression in PBMCs and increased susceptibility to coronary artery disease in a Chinese Han case-control cohort. The variant appears to affect circFOXO3 formation/expression without altering linear FOXO3 levels, suggesting a circRNA-specific regulatory effect relevant to CAD risk."	0.6238
32616043	Biological research	2020	Silencing of circular RNA ANRIL attenuates oxygen-glucose deprivation and reoxygenation-induced injury in human brain microvascular endothelial cells by sponging miR-622.	hsa_circ_0008574	circ_ANRIL	hsa_circ_ANRIL	ANRIL	cerebral ischemia_reperfusion 	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR	"circ_ANRIL is up-regulated in an in vitro cerebral ischemia_reperfusion injury model (OGD/R-treated HBMECs) and exacerbates cell injury by suppressing proliferation while promoting apoptosis and inflammatory cytokine secretion. Mechanistically, circ_ANRIL sponges miR-622 and thereby promotes NF-kappaB pathway activation; circ_ANRIL knockdown is protective and this protection is reversed by miR-622 inhibition."	0.5607
32616775	Scientific reports	2020	Identification of circRNA-associated ceRNA network in BMSCs of OVX models for postmenopausal osteoporosis.		novel circRNA 0020 			postmenopausal osteoporosis 	MONDO:0008159	postmenopausal osteoporosis	up-regulated	RT-qPCR; RNA-seq	"In OVX mouse BMSCs, circRNA 0020 is up-regulated and forms a ceRNA axis with mmu-miR-206-3p to regulate targets including Nnmt and Col3a1. It is proposed as a potentially important mechanism and biomarker for osteoporosis in this model."	0.4997
32616775	Scientific reports	2020	Identification of circRNA-associated ceRNA network in BMSCs of OVX models for postmenopausal osteoporosis.	mmu_circ_0009625	circRNA 3832 			postmenopausal osteoporosis 	MONDO:0008159	postmenopausal osteoporosis	down-regulated	RT-qPCR; RNA-seq	"In OVX mouse BMSCs, circRNA 3832 (mmu_circ_0009625) is down-regulated and is proposed to act as a ceRNA for miRNAs including mmu-miR-3473e to regulate Runx3. This ceRNA network is suggested as a potentially important mechanism and biomarker for osteoporosis in this model."	0.4997
32624692	International journal of medical sciences	2020	Circular RNA Expression Profiles and the Pro-tumorigenic Function of CircRNA_10156 in Hepatitis B Virus-Related Liver Cancer.	hsa_circ_0035431	circRNA_10156	hsa_circ_CGNL1	CGNL1	HBV-related liver cancer 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circRNA_10156 is up-regulated in HBV-related liver cancer tissues and in HepG2/Huh7 cells. Knockdown of circRNA_10156 increases miR-149-3p, decreases Akt1, and suppresses liver cancer cell proliferation, supporting a circRNA_10156/miR-149-3p/Akt1 regulatory axis."	0.6432
32626660	Frontiers in oncology	2020	RNA-Seq Profiling of Serum Exosomal Circular RNAs Reveals Circ-PNN as a Potential Biomarker for Human Colorectal Cancer.	hsa_circ_0101802	circ-PNN	hsa_circ_PNN	PNN	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"Serum exosomal circ-PNN (hsa_circ_0101802) is up-regulated in CRC patients and shows good diagnostic performance (including early-stage CRC) by ROC analysis. The study builds a predicted circ-PNN_miRNA_mRNA network and reports negative correlations between circ-PNN and hsa-miR-6833-3p, hsa-let-7i-3p, and hsa-miR-1301-3p, suggesting a potential ceRNA-related role that requires further functional validation."	0.6841
32626759	BioMed research international	2020	Profiling and Bioinformatics Analysis of Differentially Expressed circRNAs in Spinal Ligament Tissues of Patients with Ankylosing Spondylitis.	hsa_circ_0000348	hsa_circFAT3_006	hsa_circ_FAT3	FAT3	ankylosing spondylitis 	MONDO:0005306	ankylosing spondylitis	up-regulated	RNA-seq	"hsa_circ_0000348 (hsa_circFAT3_006) was identified as significantly up-regulated in spinal ligament tissues from ankylosing spondylitis patients versus controls by RNA-seq. The study did not experimentally validate its function, but included it among differentially expressed circRNAs potentially involved in AS."	0.1768
32626759	BioMed research international	2020	Profiling and Bioinformatics Analysis of Differentially Expressed circRNAs in Spinal Ligament Tissues of Patients with Ankylosing Spondylitis.	hsa_circ_0001947	hsa_circAFF2_005	hsa_circ_AFF2	AFF2	ankylosing spondylitis 	MONDO:0005306	ankylosing spondylitis	up-regulated	RNA-seq	hsa_circ_0001947 (hsa_circAFF2_005) was identified as significantly up-regulated in spinal ligament tissues from ankylosing spondylitis patients versus controls by RNA-seq. No specific downstream mechanism or functional validation for this circRNA was reported beyond differential expression and inclusion in bioinformatic analyses.	0.1768
32626759	BioMed research international	2020	Profiling and Bioinformatics Analysis of Differentially Expressed circRNAs in Spinal Ligament Tissues of Patients with Ankylosing Spondylitis.	hsa_circ_0135780	hsa_circDLC1_002	hsa_circ_DLC1	DLC1	ankylosing spondylitis 	MONDO:0005306	ankylosing spondylitis	up-regulated	RNA-seq	hsa_circ_0135780 (hsa_circDLC1_002) was identified as significantly up-regulated in spinal ligament tissues of ankylosing spondylitis patients by RNA-seq. The study provided no circRNA-specific functional experiments for this circRNA beyond differential expression and bioinformatic predictions at the cohort level.	0.1768
32626759	BioMed research international	2020	Profiling and Bioinformatics Analysis of Differentially Expressed circRNAs in Spinal Ligament Tissues of Patients with Ankylosing Spondylitis.	hsa_circ_0003915	hsa_circSATB2_015	hsa_circ_SATB2	SATB2	ankylosing spondylitis 	MONDO:0005306	ankylosing spondylitis	up-regulated	RNA-seq	hsa_circ_0003915 (hsa_circSATB2_015) was reported as significantly up-regulated in spinal ligament tissues from ankylosing spondylitis patients by RNA-seq. The paper did not provide circRNA-specific mechanistic validation for this circRNA.	0.1768
32626759	BioMed research international	2020	Profiling and Bioinformatics Analysis of Differentially Expressed circRNAs in Spinal Ligament Tissues of Patients with Ankylosing Spondylitis.	hsa_circ_0002874	hsa_circGLIS3_003	hsa_circ_GLIS3	GLIS3	ankylosing spondylitis 	MONDO:0005306	ankylosing spondylitis	up-regulated	RNA-seq	hsa_circ_0002874 (hsa_circGLIS3_003) was identified as significantly up-regulated in ankylosing spondylitis spinal ligament tissue by RNA-seq. The study did not report circRNA-specific functional or mechanistic validation for this circRNA.	0.1768
32626759	BioMed research international	2020	Profiling and Bioinformatics Analysis of Differentially Expressed circRNAs in Spinal Ligament Tissues of Patients with Ankylosing Spondylitis.	hsa_circ_0029069	hsa_circCLIP1_019	hsa_circ_CLIP1	CLIP1	ankylosing spondylitis 	MONDO:0005306	ankylosing spondylitis	up-regulated	RNA-seq	hsa_circ_0029069 (hsa_circCLIP1_019) was detected as significantly up-regulated in ankylosing spondylitis spinal ligament tissue by RNA-seq. The study only provided cohort-level enrichment and network predictions rather than circRNA-specific functional validation.	0.1768
32626759	BioMed research international	2020	Profiling and Bioinformatics Analysis of Differentially Expressed circRNAs in Spinal Ligament Tissues of Patients with Ankylosing Spondylitis.	hsa_circ_0064555	hsa_circSATB1_004	hsa_circ_SATB1	SATB1	ankylosing spondylitis 	MONDO:0005306	ankylosing spondylitis	up-regulated	RNA-seq	hsa_circ_0064555 (hsa_circSATB1_004) was reported as significantly up-regulated in spinal ligament tissues of ankylosing spondylitis patients by RNA-seq. No specific mechanism or clinical association was experimentally validated for this circRNA.	0.1768
32626759	BioMed research international	2020	Profiling and Bioinformatics Analysis of Differentially Expressed circRNAs in Spinal Ligament Tissues of Patients with Ankylosing Spondylitis.	hsa_circ_0002360	hsa_circRUNX1_005	hsa_circ_RUNX1	RUNX1	ankylosing spondylitis 	MONDO:0005306	ankylosing spondylitis	up-regulated	RNA-seq	hsa_circ_0002360 (hsa_circRUNX1_005) was among the top up-regulated circRNAs in ankylosing spondylitis spinal ligament tissue by RNA-seq. No circRNA-specific functional mechanism was experimentally confirmed in this paper.	0.1768
32626759	BioMed research international	2020	Profiling and Bioinformatics Analysis of Differentially Expressed circRNAs in Spinal Ligament Tissues of Patients with Ankylosing Spondylitis.	hsa_circ_0001861	hsa_circGRHPR_002	hsa_circ_GRHPR	GRHPR	ankylosing spondylitis 	MONDO:0005306	ankylosing spondylitis	up-regulated	RNA-seq	hsa_circ_0001861 (hsa_circGRHPR_002) was significantly up-regulated in ankylosing spondylitis spinal ligament tissue based on RNA-seq. The paper did not report circRNA-specific functional assays for this circRNA.	0.1768
32626759	BioMed research international	2020	Profiling and Bioinformatics Analysis of Differentially Expressed circRNAs in Spinal Ligament Tissues of Patients with Ankylosing Spondylitis.	hsa_circ_0130908	hsa_circUTRN_065	hsa_circ_UTRN	UTRN	ankylosing spondylitis 	MONDO:0005306	ankylosing spondylitis	down-regulated	RNA-seq	hsa_circ_0130908 (hsa_circUTRN_065) was identified as significantly down-regulated in ankylosing spondylitis spinal ligament tissue by RNA-seq. No circRNA-specific mechanistic or functional validation was reported.	0.1768
32626759	BioMed research international	2020	Profiling and Bioinformatics Analysis of Differentially Expressed circRNAs in Spinal Ligament Tissues of Patients with Ankylosing Spondylitis.	hsa_circ_0083443	hsa_circMTUS1_004	hsa_circ_MTUS1	MTUS1	ankylosing spondylitis 	MONDO:0005306	ankylosing spondylitis	down-regulated	RNA-seq	hsa_circ_0083443 (hsa_circMTUS1_004) was found significantly down-regulated in ankylosing spondylitis spinal ligament tissue by RNA-seq. No circRNA-specific functional mechanism was validated experimentally.	0.1768
32626759	BioMed research international	2020	Profiling and Bioinformatics Analysis of Differentially Expressed circRNAs in Spinal Ligament Tissues of Patients with Ankylosing Spondylitis.	hsa_circ_0006499	hsa_circGIN1_005	hsa_circ_GIN1	GIN1	ankylosing spondylitis 	MONDO:0005306	ankylosing spondylitis	down-regulated	RNA-seq	hsa_circ_0006499 (hsa_circGIN1_005) was identified as significantly down-regulated in ankylosing spondylitis spinal ligament tissue by RNA-seq. The study did not present circRNA-specific functional validation for this circRNA.	0.1768
32626759	BioMed research international	2020	Profiling and Bioinformatics Analysis of Differentially Expressed circRNAs in Spinal Ligament Tissues of Patients with Ankylosing Spondylitis.	hsa_circ_0110845	hsa_circUBAP2L_011	hsa_circ_UBAP2L	UBAP2L	ankylosing spondylitis 	MONDO:0005306	ankylosing spondylitis	down-regulated	RNA-seq	hsa_circ_0110845 (hsa_circUBAP2L_011) was identified as significantly down-regulated in ankylosing spondylitis spinal ligament tissues by RNA-seq. The study did not include circRNA-specific functional experiments for this circRNA.	0.1768
32626759	BioMed research international	2020	Profiling and Bioinformatics Analysis of Differentially Expressed circRNAs in Spinal Ligament Tissues of Patients with Ankylosing Spondylitis.	hsa_circ_0138300	hsa_circNFIB_012	hsa_circ_NFIB	NFIB	ankylosing spondylitis 	MONDO:0005306	ankylosing spondylitis	down-regulated	RNA-seq	hsa_circ_0138300 (hsa_circNFIB_012) was identified as significantly down-regulated in ankylosing spondylitis spinal ligament tissue by RNA-seq. The study linked differentially expressed circRNAs broadly to immune-related processes but did not validate a specific mechanism for this circRNA.	0.1768
32626759	BioMed research international	2020	Profiling and Bioinformatics Analysis of Differentially Expressed circRNAs in Spinal Ligament Tissues of Patients with Ankylosing Spondylitis.		hsa_circPARD3_036 	hsa_circ_PARD3	PARD3	ankylosing spondylitis 	MONDO:0005306	ankylosing spondylitis	down-regulated	RNA-seq	hsa_circPARD3_036 was identified as significantly down-regulated in ankylosing spondylitis spinal ligament tissue by RNA-seq. The article did not provide circBase 7-digit formatted ID for this circRNA and did not experimentally validate its mechanism.	0.1768
32626759	BioMed research international	2020	Profiling and Bioinformatics Analysis of Differentially Expressed circRNAs in Spinal Ligament Tissues of Patients with Ankylosing Spondylitis.	hsa_circ_0121334	hsa_circABI3BP_001	hsa_circ_ABI3BP	ABI3BP	ankylosing spondylitis 	MONDO:0005306	ankylosing spondylitis	down-regulated	RNA-seq	hsa_circ_0121334 (hsa_circABI3BP_001) was identified as significantly down-regulated in ankylosing spondylitis spinal ligament tissue by RNA-seq. The study did not provide circRNA-specific functional validation for this circRNA.	0.1768
32626774	BioMed research international	2020	The Role of circRNA-SETD2/miR-519a/PTEN Axis in Fetal Birth Weight through Regulating Trophoblast Proliferation.		hsa-circRNA-103345	hsa_circ_SETD2	SETD2	fetal macrosomia 	MONDO:0009965	Perlman syndrome	up-regulated	RT-qPCR; Microarray	"circ-SETD2 is up-regulated in placentas from fetal macrosomia cases and promotes trophoblast proliferation and invasion while reducing apoptosis. Mechanistically, it functions upstream of the miR-519a/PTEN axis by binding/restricting miR-519a, leading to increased PTEN expression."	0.6815
32626912	International journal of molecular medicine	2020	Circular RNA derived from TIMP2 functions as a competitive endogenous RNA and regulates intervertebral disc degeneration by targeting miR_185_5p and matrix metalloproteinase 2.	hsa_circ_0045942	circTIMP2	hsa_circ_TIMP2	TIMP2	intervertebral disc degeneration 	MONDO:0011385	intervertebral disk degenerative disorder	up-regulated	RT-qPCR; ISH	"circ-TIMP2 is up-regulated in degenerative NP tissues and correlates with IDD grade. It acts in the cytoplasm as a ceRNA by sponging miR-185-5p, thereby relieving repression of MMP2 and promoting ECM catabolism while suppressing ECM anabolism in NP cells."	0.8006
32626939	International journal of oncology	2020	CircRNA hsa_circ_0070934 functions as a competitive endogenous RNA to regulate HOXB7 expression by sponging miR_1236_3p in cutaneous squamous cell carcinoma.	hsa_circ_0070934	circ-0070934	hsa_circ_LARP1B	LARP1B	cutaneous squamous cell carcinoma 	MONDO:0002529	skin squamous cell carcinoma	up-regulated	RT-qPCR	"hsa_circ_0070934 (circ-0070934) is up-regulated in CSCC cell lines and promotes proliferation and invasion while inhibiting apoptosis. Mechanistically, it functions as a ceRNA that sponges miR-1236-3p to upregulate HOXB7, enhancing CSCC tumor growth in a xenograft model."	0.763
32627938	Cancer medicine	2020	Circ-SPECC1 modulates TGFbeta2 and autophagy under oxidative stress by sponging miR-33a to promote hepatocellular carcinoma tumorigenesis.	hsa_circ_0000745	circ_SPECC1	hsa_circ_SPECC1	SPECC1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"In H2O2-induced oxidative stress conditions, circ-SPECC1 is down-regulated in HCC cells but functions pro-tumorigenically. It promotes proliferation and suppresses apoptosis by sponging miR-33a, thereby relieving miR-33a-mediated repression of TGFbeta2 and modulating autophagy, and its knockdown reduces xenograft tumor growth."	0.5627
32629833	Cancers	2020	Plasma Level of Circular RNA hsa_circ_0000190 Correlates with Tumor Progression and Poor Treatment Response in Advanced Lung Cancers.	hsa_circ_0000190				lung cancer 	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000190 is up-regulated in lung cancer patients¡¯ plasma and correlates with tumor burden, metastatic status, and PD-L1 positivity. High plasma levels predict poor overall survival and poor response to systemic therapy and immunotherapy, supporting its use as a liquid-biopsy biomarker; mechanistically it is predicted to bind several miRNAs (e.g., miR-767-5p, miR-382-5p/3p, miR-1299)."	0.7399
32629833	Cancers	2020	Plasma Level of Circular RNA hsa_circ_0000190 Correlates with Tumor Progression and Poor Treatment Response in Advanced Lung Cancers.	hsa_circ_0001649	hsa_circ_000164			lung cancer 	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001649 is up-regulated in lung cancer cell lines and patients¡¯ plasma and is detectable as a secreted circulating circRNA by RT-ddPCR. It is proposed as a liquid-biopsy biomarker for monitoring immunotherapy effectiveness, and is predicted to interact with miR-942-5p, miR-889-3p, and miR-140-3p; unlike hsa_circ_0000190, high expression is not linked to worse overall survival."	0.6981
32633001	Journal of clinical laboratory analysis	2020	has_circ_CCNB1 and has_circ_0009024 function as potential biomarkers for the diagnosis of type 2 diabetes mellitus.			hsa_circ_CCNB1	CCNB1	type 2 diabetes mellitus 	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RT-qPCR	"In serum from T2DM patients, has_circ_CCNB1 is up-regulated and shows diagnostic value by ROC analysis. Its levels positively correlate with GLU, GHb, IL-6 and TNF-alpha, linking it to hyperglycemia-associated inflammation in T2DM."	0.4187
32633001	Journal of clinical laboratory analysis	2020	has_circ_CCNB1 and has_circ_0009024 function as potential biomarkers for the diagnosis of type 2 diabetes mellitus.	hsa_circ_0009024	circ_0009024 			type 2 diabetes mellitus 	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RT-qPCR	"In serum from T2DM patients, has_circ_0009024 is down-regulated and shows diagnostic value by ROC analysis. Its levels negatively correlate with GLU, GHb, IL-6 and TNF-alpha, supporting its association with glycemic control and inflammation in T2DM."	0.4187
32633429	Journal of clinical laboratory analysis	2020	Hypoxia-induced hsa_circ_0000826 is linked to liver metastasis of colorectal cancer.	hsa_circ_0000826	circ_0000826	hsa_circ_ANKRD12	ANKRD12	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH	"This study shows that hypoxia induces upregulation of hsa_circ_0000826 in CRC cells and patient serum. hsa_circ_0000826 promotes CRC malignant behaviors (migration/invasion), tumorigenesis, and liver metastasis, and its elevated serum levels have diagnostic value for CRC and CRC liver metastasis."	0.6474
32633429	Journal of clinical laboratory analysis	2020	Hypoxia-induced hsa_circ_0000826 is linked to liver metastasis of colorectal cancer.	mmu_circ_0000807				colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH	"In mouse CRC models (AOM-DSS and APCMin/+), hypoxia increases mmu_circ_0000807 expression in tumor-related tissues and serum. mmu_circ_0000807 is implicated in promoting CRC development/tumorigenesis under hypoxic conditions, supported by knockdown experiments in vivo."	0.5619
32636640	OncoTargets and therapy	2020	Circular RNA 0001073 Attenuates Malignant Biological Behaviours in Breast Cancer Cell and Is Delivered by Nanoparticles to Inhibit Mice Tumour Growth.		circRNA 0001073 	hsa_circ_ACVR2A	ACVR2A	breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	"circ-1073 (circRNA 0001073) derived from ACVR2A is down-regulated in breast cancer tissues/cells and functions as a tumor suppressor. Its overexpression inhibits proliferation, migration/invasion and EMT while promoting apoptosis, and it suppresses xenograft tumor growth, at least partly via interaction with the RBP HuR and associated changes in cleaved Caspase-3/9 and EMT markers."	0.8311
32636641	OncoTargets and therapy	2020	"A Novel Circular RNA, circ_0005394, Predicts Unfavorable Prognosis and Contributes to Hepatocellular Carcinoma Progression by Regulating miR-507/E2F3 and miR-515-5p/CXCL6 Signaling Pathways."	hsa_circ_0005394	circ_0005394	hsa_circ_ZC3H7A	ZC3H7A	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0005394 is up-regulated in HCC tissues and cell lines and acts as an oncogenic circRNA. It promotes proliferation/viability, migration and invasion and suppresses apoptosis by sponging miR-507 and miR-515-5p to de-repress E2F3 and CXCL6 (miR-507/E2F3 and miR-515-5p/CXCL6 axes). High circ_0005394 expression predicts poorer overall survival and is an independent prognostic factor in an 82-patient cohort."	0.7408
32636647	OncoTargets and therapy	2020	Down-Regulation of circNRIP1 Promotes the Apoptosis and Inhibits the Migration and Invasion of Gastric Cancer Cells by miR-182/ROCK1 Axis.	hsa_circ_0002711	circNRIP1 	hsa_circ_NRIP1	NRIP1	gastric cancer	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circNRIP1 is up-regulated in gastric cancer and higher levels are associated with worse overall survival. Functionally, circNRIP1 promotes migration and invasion and suppresses apoptosis by sponging miR-182, thereby derepressing ROCK1 expression (circNRIP1/miR-182/ROCK1 ceRNA axis)."	0.7992
32636650	OncoTargets and therapy	2020	Hsa_circ_0001806 Acts as a ceRNA to Facilitate the Stemness of Colorectal Cancer Cells by Increasing COL1A1.	hsa_circ_0001806	hsa_circ_000180			colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001806 is upregulated in colorectal cancer and promotes cancer cell stemness and tumor-initiating ability. It functions as a ceRNA by sponging miR-193a-5p to relieve repression of COL1A1, forming a hsa_circ_0001806/miR-193a-5p/COL1A1 axis associated with advanced clinicopathologic features and poorer overall survival."	0.8625
32639948	Aging	2020	Altered circular RNA expression profiles in the non-ischemic thalamus in focal cortical infarction mice.		mmu_circ:chr2:74568941-74573626 	mmu_circ_Lnp	Lnp	focal cortical infarction 	MONDO:0005394	brain infarction	up-regulated	RT-qPCR; RNA-seq	"mmu_circ:chr2:74568941-74573626 (circ-Lnp) is significantly up-regulated in the non-ischemic ipsilateral thalamus at 14 days after distal MCAO. The study predicts it may act as a miRNA sponge (e.g., miR-122-5p and miR-1271-5p) within a circRNA-miRNA-mRNA network potentially related to post-stroke secondary thalamic alterations."	0.4997
32639948	Aging	2020	Altered circular RNA expression profiles in the non-ischemic thalamus in focal cortical infarction mice.		mmu_circ:chr8:8639206-8639489 	mmu_circ_Efnb2	Efnb2	focal cortical infarction 	MONDO:0005394	brain infarction	up-regulated	RT-qPCR; RNA-seq	mmu_circ:chr8:8639206-8639489 (circ-Efnb2) is significantly up-regulated in the non-ischemic ipsilateral thalamus at 14 days after distal MCAO. The study predicts it may function in a ceRNA manner by binding miR-141-5p within a circRNA-miRNA-mRNA network potentially linked to secondary thalamic alterations after stroke.	0.4997
32640974	"Molecular medicine (Cambridge, Mass.)"	2020	circCELSR1 facilitates ovarian cancer proliferation and metastasis by sponging miR-598 to activate BRD4 signals.	hsa_circ_0063809	circCELSR1 	hsa_circ_CELSR1	CELSR1	ovarian cancer	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circCELSR1 is up-regulated in ovarian cancer cells and promotes proliferation, migration/invasion, EMT and in vivo metastasis while inhibiting apoptosis. Mechanistically, it sponges miR-598 to de-repress BRD4 and activate BRD4-associated pro-tumor signaling."	0.6542
32644049	Aging	2020	circRNA_100859 functions as an oncogene in colon cancer by sponging the miR-217-HIF-1alpha pathway.		circRNA_100859 	hsa_circ_KDM2A	KDM2A	colon cancer	MONDO:0021063	malignant colon neoplasm	up-regulated	RT-qPCR; Microarray	"circRNA_100859 is up-regulated in colon cancer tissues and promotes proliferation while inhibiting apoptosis. Mechanistically, it functions as a ceRNA that sponges miR-217, thereby relieving miR-217-mediated repression of HIF-1alpha and contributing to colon cancer progression. High circRNA_100859 is associated with worse PFS and shows diagnostic/prognostic value."	0.7588
32645691	Aging	2020	Circular RNA circMBOAT2 promotes prostate cancer progression via a miR-1271-5p/mTOR axis.	hsa_circ_0007334	circMBOAT2	hsa_circ_MBOAT2	MBOAT2	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; RNA-seq	"circMBOAT2 is up-regulated in prostate cancer tissues and cell lines and promotes proliferation, migration, invasion, tumor growth and metastasis. It functions as a ceRNA that sponges miR-1271-5p to de-repress mTOR, activating PI3K/Akt signaling; high circMBOAT2 is associated with shorter DFS."	0.8837
32647666	Annals of translational medicine	2020	CircRNA ZNF609 in peripheral blood leukocytes acts as a protective factor and a potential biomarker for coronary artery disease.	hsa_circ_0000615	circZNF609 	hsa_circ_ZNF609	ZNF609	coronary artery disease 	MONDO:0005010	coronary artery disorder	down-regulated	RT-qPCR	"circZNF609 (hsa_circ_0000615) is down-regulated in peripheral blood leukocytes from CAD patients and is independently associated with lower CAD risk. Functionally, its overexpression in RAW264.7 macrophages reduces pro-inflammatory cytokines (IL-6, TNF-alpha) and increases IL-10, supporting an anti-inflammatory protective role; a ceRNA/miRNA-sponge mechanism was proposed via bioinformatics and literature."	0.7156
32648571	Bioscience reports	2020	Hsa_circ_0026134 expression promoted TRIM25- and IGF2BP3-mediated hepatocellular carcinoma cell proliferation and invasion via sponging miR-127-5p.	hsa_circ_0026134	circRNA TUBA1C	hsa_circ_TUBA1C	TUBA1C	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"hsa_circ_0026134 is up-regulated in HCC tissues and cell lines and functions as an oncogenic circRNA. It sponges miR-127-5p to increase TRIM25 and IGF2BP3, thereby promoting HCC cell proliferation and migration/invasion and supporting xenograft tumor growth."	0.5607
32651991	Aging	2020	Depletion of exosomal circLDLR in follicle fluid derepresses miR-1294 function and inhibits estradiol production via CYP19A1 in polycystic ovary syndrome.	hsa_circ_0006877	circLDLR	hsa_circ_LDLR	LDLR	polycystic ovary syndrome 	MONDO:0008487	polycystic ovary syndrome	down-regulated	RT-qPCR; RNA-seq	"Exosomal circLDLR (hsa_circ_0006877) is decreased in follicular fluid exosomes from PCOS patients. It acts as a ceRNA by sponging miR-1294, thereby relieving repression of CYP19A1 and modulating aromatase-dependent estradiol (E2) production in granulosa cells."	0.7684
32652519	Aging	2020	The circular RNA circEIF3M promotes breast cancer progression by promoting cyclin D1 expression.	hsa_circ_0003119	circEIF3M 	hsa_circ_EIF3M	EIF3M	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; RNA-seq	"circEIF3M is up-regulated in TNBC tissues and promotes proliferation, migration, invasion, cell-cycle progression, and tumor growth. Mechanistically, it functions as a ceRNA that sponges miR-33a to derepress CCND1 (cyclin D1), forming a circEIF3M/miR-33a/CCND1 axis."	0.7422
32653032	Journal of experimental & clinical cancer research : CR	2020	Circular RNA circNTRK2 facilitates the progression of esophageal squamous cell carcinoma through up-regulating NRIP1 expression via miR-140-3p.	hsa_circ_0087378	circNTRK2	hsa_circ_NTRK2	NTRK2	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"circNTRK2 is up-regulated in ESCC and promotes malignant phenotypes (proliferation, invasion, EMT) while inhibiting apoptosis. It acts mainly in the cytoplasm as a ceRNA, sponging miR-140-3p to increase NRIP1 expression, and its high expression associates with advanced stage and poorer survival."	0.8689
32655319	Cancer cell international	2020	"CircRNA hsa_circRNA_0000069 promotes the proliferation, migration and invasion of cervical cancer through miR-873-5p/TUSC3 axis."	hsa_circ_0000069				cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000069 is up-regulated in cervical cancer and promotes proliferation, migration, invasion, and xenograft tumor growth. It functions as a ceRNA by sponging miR-873-5p, thereby increasing TUSC3 expression, and its high expression is associated with lymph node metastasis and poor overall survival."	0.7855
32655321	Cancer cell international	2020	CircRNA CDR1as/miR-641/HOXA9 pathway regulated stemness contributes to cisplatin resistance in non-small cell lung cancer (NSCLC).		circRNA CDR1as 	hsa_circ_CDR1	CDR1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"In NSCLC cisplatin-resistant models, circRNA CDR1as is up-regulated and promotes cisplatin chemoresistance and cancer stemness. It functions as a ceRNA by sponging miR-641 to increase HOXA9 expression; CDR1as knockdown sensitizes resistant cells to cisplatin and reduces stemness via the miR-641/HOXA9 axis."	0.7045
32655392	Frontiers in aging neuroscience	2020	Identification of the Potential Key Circular RNAs in Elderly Patients With Postoperative Cognitive Dysfunction.		hsa_circ_001145 	hsa_circ_CPNE1	CPNE1	postoperative cognitive dysfunction 	MONDO:0002039	cognitive disorder	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_001145 is significantly up-regulated in POCD patient serum and was included in the validated differentially expressed circRNAs. The study predicts it may function as a ceRNA by sponging miRNAs (e.g., miR-1226-5p) to influence target genes such as ITSN1 in a circRNA_miRNA_mRNA network relevant to POCD-related processes."	0.4761
32655392	Frontiers in aging neuroscience	2020	Identification of the Potential Key Circular RNAs in Elderly Patients With Postoperative Cognitive Dysfunction.		hsa_circ_101138 	hsa_circ_UBE3B	UBE3B	postoperative cognitive dysfunction 	MONDO:0002039	cognitive disorder	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_101138 is significantly up-regulated in POCD patient serum and was among the circRNAs used to build the predicted circRNA_miRNA_mRNA network. Bioinformatics suggests it may sponge miRNAs such as miR-107 and miR-376a/b-3p to affect targets including NEDD9, GSKIP and HAS2, linking it to POCD-relevant neurodegeneration-related gene regulation."	0.4761
32655392	Frontiers in aging neuroscience	2020	Identification of the Potential Key Circular RNAs in Elderly Patients With Postoperative Cognitive Dysfunction.		hsa_circ_030050 	hsa_circ_ELF1	ELF1	postoperative cognitive dysfunction 	MONDO:0002039	cognitive disorder	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_030050 is up-regulated in POCD patient serum and was experimentally validated by RT-qPCR consistent with microarray results. The study provides predicted interacting miRNAs for this circRNA via bioinformatics, but no specific downstream targets or pathways were experimentally established."	0.4761
32655392	Frontiers in aging neuroscience	2020	Identification of the Potential Key Circular RNAs in Elderly Patients With Postoperative Cognitive Dysfunction.		hsa_circ_061570 	hsa_circ_ITSN1	ITSN1	postoperative cognitive dysfunction 	MONDO:0002039	cognitive disorder	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_061570 is significantly up-regulated in POCD patient serum and was used to construct the predicted circRNA_miRNA_mRNA interaction network. The paper suggests it may regulate its parent gene ITSN1 (and shared targets such as BCL2L2) via predicted ceRNA interactions and possibly an RBP-related mechanism, linking it to RAS/MAPK-associated inflammation/apoptosis contexts in POCD."	0.4761
32655392	Frontiers in aging neuroscience	2020	Identification of the Potential Key Circular RNAs in Elderly Patients With Postoperative Cognitive Dysfunction.		hsa_circ_005537 	hsa_circ_CDC25C	CDC25C	postoperative cognitive dysfunction 	MONDO:0002039	cognitive disorder	down-regulated	RT-qPCR; Microarray	hsa_circRNA_005537 is down-regulated in POCD patient serum and was validated by RT-qPCR consistent with the microarray. The study reports predicted miRNA response elements for this circRNA but does not experimentally establish a specific downstream pathway or function in POCD.	0.4761
32655392	Frontiers in aging neuroscience	2020	Identification of the Potential Key Circular RNAs in Elderly Patients With Postoperative Cognitive Dysfunction.		hsa_circ_092522 	hsa_circ_GRAMD4	GRAMD4	postoperative cognitive dysfunction 	MONDO:0002039	cognitive disorder	down-regulated	RT-qPCR; Microarray	hsa_circRNA_092522 is down-regulated in POCD patient serum and was validated by RT-qPCR consistent with microarray results. The study provides predicted miRNA response elements for this circRNA but no specific experimentally supported downstream mechanism in POCD.	0.4761
32655392	Frontiers in aging neuroscience	2020	Identification of the Potential Key Circular RNAs in Elderly Patients With Postoperative Cognitive Dysfunction.		hsa_circ_005458 	hsa_circ_AC114755.7	AC114755.7	postoperative cognitive dysfunction 	MONDO:0002039	cognitive disorder	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_005458 is down-regulated in POCD patient serum and was validated by RT-qPCR consistent with microarray results. The paper reports predicted miRNA response elements for this circRNA, without experimentally confirmed downstream targets or pathways in POCD."	0.4761
32655392	Frontiers in aging neuroscience	2020	Identification of the Potential Key Circular RNAs in Elderly Patients With Postoperative Cognitive Dysfunction.		hsa_circ_050545 	hsa_circ_UBA2	UBA2	postoperative cognitive dysfunction 	MONDO:0002039	cognitive disorder	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_050545 is up-regulated in POCD patient serum and was validated by RT-qPCR consistent with the microarray. The paper lists predicted miRNA response elements for this circRNA, but no specific downstream targets or pathways were experimentally confirmed in POCD."	0.4761
32655392	Frontiers in aging neuroscience	2020	Identification of the Potential Key Circular RNAs in Elderly Patients With Postoperative Cognitive Dysfunction.		hsa_circRNA_401117	hsa_circ_ZNF10	ZNF10	postoperative cognitive dysfunction 	MONDO:0002039	cognitive disorder	unknown	Microarray	"hsa_circRNA_401117 was reported among the top dysregulated circRNAs identified by circRNA microarray in POCD serum, with predicted miRNA response elements from bioinformatics. The article does not report RT-qPCR validation results or a confirmed direction of change for this specific circRNA in the main text."	0.329
32655392	Frontiers in aging neuroscience	2020	Identification of the Potential Key Circular RNAs in Elderly Patients With Postoperative Cognitive Dysfunction.		hsa_circRNA_012989	hsa_circ_USP33	USP33	postoperative cognitive dysfunction 	MONDO:0002039	cognitive disorder	unknown	Microarray	"hsa_circRNA_012989 was reported among the top dysregulated circRNAs identified by circRNA microarray in POCD serum, with predicted miRNA response elements. The main text does not report RT-qPCR validation outcomes or the specific direction of change for this circRNA."	0.329
32660590	"Critical care (London, England)"	2020	The circular RNA landscape in specific peripheral blood mononuclear cells of critically ill patients with sepsis.		circVCAN 	hsa_circ_VCAN	VCAN	sepsis 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RNA-seq	"circVCAN is significantly increased in CD14+ monocytes from sepsis patients secondary to CAP versus healthy controls based on RNA-seq. The study experimentally confirms circVCAN is a bona fide RNase R_resistant circular transcript in healthy human monocytes, but does not establish a specific miRNA-sponge mechanism or direct downstream targets."	0.437
32660590	"Critical care (London, England)"	2020	The circular RNA landscape in specific peripheral blood mononuclear cells of critically ill patients with sepsis.		circCHD2 	hsa_circ_CHD2	CHD2	sepsis 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RNA-seq	"circCHD2 is significantly increased in CD14+ monocytes from sepsis patients secondary to CAP versus healthy controls based on RNA-seq. The study confirms circCHD2 is RNase R_resistant and detectable by divergent-primer qRT-PCR in healthy human monocytes, but does not support a miRNA sequestration role or define downstream targets."	0.437
32661238	Cell death & disease	2020	Circ-ADAM9 targeting PTEN and ATG7 promotes autophagy and apoptosis of diabetic endothelial progenitor cells by sponging mir-20a-5p.	hsa_circ_0001791	circ-ADAM9 	hsa_circ_ADAM9	ADAM9	diabetes mellitus 	MONDO:0005015	diabetes mellitus	up-regulated	RT-qPCR	"In high-glucose (diabetic) conditions, circ-ADAM9 is up-regulated in EPCs and mainly localizes to the cytoplasm. It sponges mir-20a-5p to upregulate PTEN and ATG7, inhibit AKT/mTOR phosphorylation, and thereby promote autophagy and apoptosis while impairing angiogenic capacity; circ-ADAM9 knockdown improves perfusion and microvessel formation in diabetic hind limb ischemia."	0.7663
32662258	Diabetes & metabolism journal	2020	Differential Profile of Plasma Circular RNAs in Type 1 Diabetes Mellitus.		hsa_circRNA_101062			type 1 diabetes mellitus 	MONDO:0005147	type 1 diabetes mellitus	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_101062 is up-regulated in plasma from new-onset T1DM patients. It is predicted (in silico) to function in a circRNA_miRNA_mRNA regulatory network and may act as a hub upstream of hsa-miR-660-3p and hsa-miR-612, linking to inflammation/immune-related processes in T1DM."	0.5135
32662258	Diabetes & metabolism journal	2020	Differential Profile of Plasma Circular RNAs in Type 1 Diabetes Mellitus.		hsa_circRNA_100332			type 1 diabetes mellitus 	MONDO:0005147	type 1 diabetes mellitus	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_100332 is significantly up-regulated in plasma of new-onset T1DM patients (validated by qRT-PCR). It is predicted to sponge miRNAs (e.g., hsa-miR-892a) and participate in inflammation/immune-related regulatory networks implicated in T1DM."	0.5135
32662258	Diabetes & metabolism journal	2020	Differential Profile of Plasma Circular RNAs in Type 1 Diabetes Mellitus.		hsa_circRNA_085129 			type 1 diabetes mellitus 	MONDO:0005147	type 1 diabetes mellitus	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_085129 is significantly up-regulated in plasma of new-onset T1DM patients (validated by qRT-PCR). It is predicted to sponge hsa-miR-145-5p and contribute to inflammation/immune-related regulatory networks implicated in T1DM, suggesting potential biomarker value."	0.5135
32662258	Diabetes & metabolism journal	2020	Differential Profile of Plasma Circular RNAs in Type 1 Diabetes Mellitus.		hsa_circRNA_103845			type 1 diabetes mellitus 	MONDO:0005147	type 1 diabetes mellitus	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_103845 is significantly up-regulated in plasma from new-onset T1DM patients (validated by qRT-PCR). It is predicted to interact with miRNAs including hsa-miR-127-3p and sponge hsa-miR-432-5p, linking it to inflammation/immune-related regulatory networks implicated in T1DM."	0.5135
32664176	Medicine	2020	Hsa_circ_0002320: a novel clinical biomarker for colorectal cancer prognosis.	hsa_circ_0002320		hsa_circ_YAP1	YAP1	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"hsa_circ_0002320 (host gene YAP1) is down-regulated in CRC plasma and tumor tissues. Higher hsa_circ_0002320 is associated with longer overall survival and shows good diagnostic performance (ROC AUC 0.823), suggesting it as a noninvasive prognostic/diagnostic biomarker; bioinformatics links it to ubiquitination-related processes."	0.5121
32664914	BMC complementary medicine and therapies	2020	A circRNA-miRNA-mRNA network plays a role in the protective effect of diosgenin on alveolar bone loss in ovariectomized rats.		rno_circRNA_016717 			alveolar bone loss 	MONDO:0005076	periodontitis	up-regulated	RT-qPCR; Microarray	"rno_circRNA_016717 is up-regulated in alveolar bone in DIO-treated OVX rats versus OVX controls, and it is the only circRNA validated by RT-qPCR. It is proposed to participate in a circRNA_016717/miR-501-5p/Sfrp1 axis that may contribute to DIO¡¯s protective effect on OVX-induced alveolar bone loss, potentially via Wnt- and PI3K-related regulation of osteogenesis/osteoclastogenesis."	0.4997
32666646	Journal of clinical laboratory analysis	2020	Value of circular RNA 0007385 in disease monitoring and prognosis estimation in non-small-cell lung cancer patients.	hsa_circ_0007385	circular RNA_0007385			non_small_cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"In resected NSCLC patient tissues, hsa_circ_0007385 is up-regulated in tumors versus adjacent non-tumor tissues and can distinguish tumors from controls. High tumor hsa_circ_0007385 expression associates with more advanced disease features (lymph node metastasis, higher TNM stage) and predicts worse DFS/OS, independently predicting worse OS."	0.5918
32667627	Bioscience reports	2020	Circular RNA S-7 promotes ovarian cancer EMT via sponging miR-641 to up-regulate ZEB1 and MDM2.		ciRS-7 	hsa_circ_CDR1AS		ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"In ovarian cancer, ciRS-7 is up-regulated and promotes tumor growth and metastatic phenotypes (migration/invasion) by enhancing EMT. Mechanistically, ciRS-7 functions as a ceRNA that sponges miR-641 to increase ZEB1 and MDM2 expression, and high ciRS-7 is associated with poorer overall survival."	0.7548
32667746	Journal of cellular and molecular medicine	2020	Oestrogen induces epithelial-mesenchymal transition in endometriosis via circ_0004712/miR-148a-3p sponge function.	hsa_circ_0004712	circ_0004712 			endometriosis	MONDO:0005133	endometriosis	up-regulated	RT-qPCR	"circ_0004712 is induced by estrogen (E2) in endometrial epithelial cells and promotes E2-driven EMT and migration. Mechanistically, it sponges miR-148a-3p, relieving repression of SOS2 and contributing to activation of beta-catenin signaling."	0.5416
32668414	Aging	2020	CircRNA FGFR3 induces epithelial-mesenchymal transition of ovarian cancer by regulating miR-29a-3p/E2F1 axis.		circFGFR3 	hsa_circ_FGFR3	FGFR3	ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circFGFR3 is up-regulated in ovarian cancer tissues/cells and promotes OC progression by inducing EMT. It functions as a ceRNA by sponging miR-29a-3p to increase E2F1 expression, enhancing proliferation/viability, invasion/migration, and tumor growth/metastasis; high circFGFR3 is associated with poor prognosis and recurrence."	0.8198
32669871	Cancer management and research	2020	Sevoflurane Regulates Glioma Progression by Circ_0002755/miR-628-5p/MAGT1 Axis.	hsa_circ_0002755	circ_0002755 			glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ_0002755 is up-regulated in glioma tissues/cells and functions as an oncogenic circRNA. It sponges miR-628-5p to regulate MAGT1, affecting proliferation/viability, apoptosis, migration/invasion, and glycolysis, and it counteracts the anti-tumor effects of sevoflurane in vitro and in a xenograft model."	0.6536
32669952	International journal of medical sciences	2020	Circular RNA Hsa_circ_0066755 as an Oncogene via sponging miR-651 and as a Promising Diagnostic Biomarker for Nasopharyngeal Carcinoma.	hsa_circ_0066755	hsa_circ_006675	hsa_circ_KIAA1524	KIAA1524	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"hsa_circ_0066755 is up-regulated in NPC plasma and tissues and shows diagnostic value by ROC analysis. Functionally, it promotes NPC cell proliferation, colony formation, migration/invasion, and xenograft tumor growth. Mechanistically, it acts as a cytoplasmic miRNA sponge for miR-651, supported by luciferase and rescue assays."	0.7859
32669960	International journal of medical sciences	2020	Circular RNA hsa-circ-0007766 modulates the progression of Gastric Carcinoma via miR-1233-3p/GDF15 axis.		hsa-circ-0007766 	hsa_circ_ERBB2	ERBB2	gastric carcinoma 	MONDO:0004950	gastric carcinoma	up-regulated	RT-qPCR	"hsa-circ-0007766 is up-regulated in gastric carcinoma tissues and cell lines and promotes malignant behaviors (proliferation, migration, invasion, colony formation). Mechanistically, it functions as a ceRNA by sponging miR-1233-3p to increase GDF15 expression, and it shows potential diagnostic value by ROC analysis."	0.8562
32669971	Cancer cell international	2020	Circ-DENND4C up-regulates TCF4 expression to modulate hepatocellular carcinoma cell proliferation and apoptosis via activating Wnt/beta-catenin signal pathway.		circ-DENND4C	hsa_circ_DENND4C	DENND4C	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"In HCC cell models, circ-DENND4C is up-regulated and promotes proliferation, cell cycle progression, invasion and stemness while inhibiting apoptosis. Mechanistically, circ-DENND4C sponges miR-195-5p to up-regulate TCF4 and activate Wnt/beta-catenin signaling, and it enhances xenograft tumor growth in vivo."	0.8635
32669977	Cancer cell international	2020	Circ_0000527 promotes the progression of retinoblastoma by regulating miR-646/LRP6 axis.	hsa_circ_0000527	circ_0000527			retinoblastoma 	MONDO:0008380	retinoblastoma	up-regulated	RT-qPCR	"circ_0000527 is up-regulated in retinoblastoma tissues and RB cell lines and promotes proliferation, migration and invasion while inhibiting apoptosis. Mechanistically, it functions as a ceRNA to sponge miR-646 and thereby increases LRP6 expression, forming a circ_0000527/miR-646/LRP6 axis that drives RB progression."	0.7032
32670434	Disease markers	2020	Plasma-Derived Exosomal Circular RNA hsa_circ_0005540 as a Novel Diagnostic Biomarker for Coronary Artery Disease.	hsa_circ_0005540		hsa_circ_MCTP1	MCTP1	coronary artery disease 	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR; RNA-seq	"Plasma-derived exosomal hsa_circ_0005540 is up-regulated in CAD patients versus non-CAD controls and shows strong diagnostic performance (AUC 0.853) when combined with FHS risk factors. The paper suggests a possible miRNA-sponge role via predicted binding sites for miR-221 and miR-145, but no definitive functional mechanism is experimentally established."	0.5047
32670874	Frontiers in oncology	2020	A Novel Circular RNA hsa_circRPPH1_015 Exerts an Oncogenic Role in Breast Cancer by Impairing miRNA-326-Mediated ELK1 Inhibition.	hsa_circ_0000517	hsa_circRPPH1_015 	hsa_circ_RPPH1	RPPH1	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Northern Blot; Microarray	"In breast cancer, hsa_circRPPH1_015 is up-regulated and functions as an oncogenic circRNA that promotes proliferation, invasion, cell-cycle progression, and xenograft tumor growth/metastasis. Mechanistically, it binds (sponges) miR-326 in an Ago2-associated manner, relieving miR-326-mediated repression of ELK1, thereby enhancing ELK1-driven malignant phenotypes. Clinically, high hsa_circRPPH1_015 expression is associated with worse patient survival."	0.8648
32671065	Frontiers in cell and developmental biology	2020	hsa_circ_0026827 Promotes Osteoblast Differentiation of Human Dental Pulp Stem Cells Through the Beclin1 and RUNX1 Signaling Pathways by Sponging miR-188-3p.	hsa_circ_0026827	hsa_circ_ 0026827			osteoporosis	MONDO:0005298	osteoporosis	up-regulated	RT-qPCR	"hsa_circ_0026827 is upregulated during osteogenic differentiation of human DPSCs and promotes osteoblast differentiation and heterotopic bone formation. Mechanistically, it sponges miR-188-3p to relieve repression of Beclin1 (autophagy) and RUNX1, thereby enhancing osteogenic programs."	0.6479
32675386	Aging	2020	Circular RNA-9119 suppresses in ovarian cancer cell viability via targeting the microRNA-21-5p-PTEN-Akt pathway.		circRNA-9119 			ovarian cancer 	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR; Microarray	"circ9119 is down-regulated in ovarian cancer tissues and cell lines. Its overexpression suppresses OC cell proliferation/viability and promotes apoptosis by sponging miR-21-5p, thereby increasing PTEN and inhibiting Akt signaling, and it reduces xenograft tumor growth."	0.6004
32675746	Chinese medical journal	2020	CircHECTD1 up-regulates mucin 1 expression to accelerate hepatocellular carcinoma development by targeting microRNA-485-5p via a competing endogenous RNA mechanism.		circHECTD1	hsa_circ_HECTD1	HECTD1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circHECTD1 is up-regulated in HCC tissues and promotes malignant phenotypes of HepG2 cells. It functions as a ceRNA by sponging miR-485-5p, thereby relieving repression of MUC1 and facilitating proliferation, migration/invasion, and anti-apoptosis effects."	0.7032
32681011	Nature communications	2020	CircGRIA1 shows an age-related increase in male macaque brain and regulates synaptic plasticity and synaptogenesis.		circGRIA1		Gria1	brain aging 			up-regulated	RT-qPCR; Northern Blot; ISH; RNA-seq	"circGRIA1 is an age- and male-biased upregulated macaque brain circRNA derived from Gria1. It localizes mainly to the nucleus and associates with the Gria1 promoter/5¡ä-UTR region to suppress Gria1 transcription, reducing Gria1 mRNA/GluR1 protein and contributing to age-related synaptogenesis and synaptic plasticity deficits; circGRIA1 knockdown reverses these effects in males."	0.7939
32681092	Cell death & disease	2020	CircAGFG1 drives metastasis and stemness in colorectal cancer by modulating YY1/CTNNB1.		circAGFG1	hsa_circ_AGFG1	AGFG1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circAGFG1 is upregulated in colorectal cancer cells and tissues and promotes proliferation, migration/invasion, stemness, tumor growth and metastasis while inhibiting apoptosis. Mechanistically, it sponges miR-4262 and miR-185-5p to increase YY1, which transcriptionally activates CTNNB1 and thereby activates Wnt/beta-catenin signaling."	0.8785
32681581	Journal of cellular and molecular medicine	2020	Hsa_circ_0128846 promotes tumorigenesis of colorectal cancer by sponging hsa-miR-1184 and releasing AJUBA and inactivating Hippo/YAP signalling.	hsa_circ_0128846		hsa_circ_ZFR	ZFR	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"hsa_circ_0128846 (circ_0128846) is up-regulated in colorectal cancer tissues and CRC cell lines. It promotes CRC proliferation, migration, invasion, cell cycle progression and tumor growth by sponging miR-1184, thereby increasing AJUBA and inactivating Hippo/YAP signaling."	0.7801
32681720	Aging	2020	Downregulation of hsa_circ_0007580 inhibits non-small cell lung cancer tumorigenesis by reducing miR-545-3p sponging.	hsa_circ_0007580		hsa_circ_PRKCA	PRKCA	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0007580 is up-regulated in NSCLC and promotes tumorigenesis. Functionally, its knockdown suppresses proliferation and invasion and induces apoptosis in NSCLC cells and xenografts. Mechanistically, hsa_circ_0007580 sponges miR-545-3p to derepress PRKCA and activate p38/MAPK signaling."	0.7415
32684842	Cancer cell international	2020	Circular RNA hsa_circ_0005909 modulates osteosarcoma progression via the miR-936/HMGB1 axis.	hsa_circ_0005909	circ_0005909	hsa_circ_XPR1	XPR1	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"hsa_circ_0005909 (circ_0005909) is up-regulated in osteosarcoma tissues/cells and is associated with poorer overall survival. Functionally, circ_0005909 promotes osteosarcoma malignant behaviors and tumor growth by sponging miR-936, thereby relieving miR-936-mediated repression of HMGB1 (circ_0005909/miR-936/HMGB1 axis)."	0.817
32685526	BioMed research international	2020	circITGA7 Functions as an Oncogene by Sponging miR-198 and Upregulating FGFR1 Expression in Thyroid Cancer.		circITGA7	hsa_circ_ITGA7	ITGA7	thyroid cancer 	MONDO:0002108	thyroid cancer	up-regulated	RT-qPCR	"circITGA7 is upregulated in thyroid cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes thyroid cancer cell proliferation and metastatic behaviors by acting as a ceRNA that sponges miR-198, thereby relieving miR-198-mediated repression of FGFR1 and increasing FGFR1 expression."	0.6777
32685551	BioMed research international	2020	ciRS-7 Promotes the Proliferation and Migration of Papillary Thyroid Cancer by Negatively Regulating the miR-7/Epidermal Growth Factor Receptor Axis.		ciRS-7 	hsa_circ_CDR1	CDR1	papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"ciRS-7 is up-regulated in papillary thyroid cancer tissues and cell lines. Functionally, it promotes PTC cell proliferation, migration and invasion (partly via EMT) by sponging miR-7 and thereby increasing EGFR expression."	0.713
32686598	Gut microbes	2020	Gut microbiota regulate tumor metastasis via circRNA/miRNA networks.	mmu_circ_0000730				cancer metastasis 	MONDO:0024880	metastatic malignant neoplasm	dysregulated	RT-qPCR; Microarray	"mmu_circ_0000730 is a gut microbiota- and IL-11-regulated circRNA that promotes tumor metastasis by sponging mmu-miR-466i-3p/mmu-miR-466 f-3p, thereby increasing SOX9 and activating STAT3-associated EMT and cancer stemness programs. Silencing mmu_circ_0000730 reduces invasion and metastasis in mouse models and decreases CD133+ ALDH1A1+ cancer stem-like cells."	0.756
32690086	Journal of ovarian research	2020	circRNA-UBAP2 promotes the proliferation and inhibits apoptosis of ovarian cancer though miR-382-5p/PRPF8 axis.		circRNA-UBAP2	hsa_circ_UBAP2	UBAP2	ovarian cancer	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circRNA-UBAP2 is up-regulated in ovarian cancer tissues and cell lines and functions as an oncogenic circRNA. It sponges miR-382-5p to relieve repression of PRPF8, thereby promoting proliferation, inhibiting apoptosis, and influencing cell-cycle progression in ovarian cancer cells."	0.6521
32692470	Journal of cellular and molecular medicine	2020	Circulating circRNA predicting the occurrence of hepatocellular carcinoma in patients with HBV infection.	hsa_circ_0009582	circ_0009582			hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0009582 is up-regulated in plasma (and tumor tissue) of HBV-related HCC patients versus CH or healthy controls, and decreases after hepatectomy. It serves as a candidate circulating fingerprint/biomarker, especially when combined with AFP, to predict or distinguish HCC occurrence in HBV-infected patients."	0.5963
32692470	Journal of cellular and molecular medicine	2020	Circulating circRNA predicting the occurrence of hepatocellular carcinoma in patients with HBV infection.	hsa_circ_0037120	circ_0037120			hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0037120 is up-regulated in plasma (and tumor tissue) of HBV-related HCC patients versus CH or healthy controls, and decreases after hepatectomy. It is proposed as a circulating diagnostic fingerprint/biomarker and improves prediction when combined with AFP."	0.5963
32692470	Journal of cellular and molecular medicine	2020	Circulating circRNA predicting the occurrence of hepatocellular carcinoma in patients with HBV infection.	hsa_circ_0140117	circ_0140117			hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0140117 is up-regulated in plasma (and tumor tissue) of HBV-related HCC patients versus CH or healthy controls, and decreases after hepatectomy. It is a candidate circulating biomarker/fingerprint whose combination with AFP yields higher diagnostic sensitivity and specificity."	0.5963
32693639	Cell transplantation	2020	Circular RNA_CNST Promotes the Tumorigenesis of Osteosarcoma Cells by Sponging miR-421.	hsa_circ_0017311	circCNST	hsa_circ_CNST	CNST	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; ISH; Microarray	"circCNST (hsa_circ_0017311), derived from the CNST locus, is up-regulated in osteosarcoma tissues and cell lines and is associated with larger tumor size and poorer overall survival. Functionally, circCNST promotes OS cell proliferation/colony formation and xenograft growth by sponging miR-421 in the cytoplasm, thereby increasing SLC25A3 expression."	0.8717
32697386	Journal of cellular and molecular medicine	2020	"CircRHOT1 mediated cell proliferation, apoptosis and invasion of pancreatic cancer cells by sponging miR-125a-3p."	hsa_circ_0005397	circRHOT1	hsa_circ_RHOT1	RHOT1	pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"circRHOT1 is up-regulated in PDAC tissues and pancreatic cancer cell lines. It promotes proliferation and invasion and suppresses apoptosis by sponging miR-125a-3p, thereby increasing E2F3 expression."	0.6973
32698139	"Reproduction (Cambridge, England)"	2020	Estrogen-decreased hsa_circ_0001649 promotes stromal cell invasion in endometriosis.	hsa_circ_0001649		hsa_circ_SHPRH	SHPRH	Endometriosis 	MONDO:0005133	endometriosis	down-regulated	RT-qPCR	"In endometriosis, hsa_circ_0001649 is decreased in eutopic and ectopic endometrium and is downregulated by estradiol via estrogen receptors. Reduced hsa_circ_0001649 contributes to E2-driven MMP9 upregulation and promotes stromal cell migration and invasion, while circRNA overexpression reverses these effects."	0.6672
32699532	Cancer cell international	2020	"circ_0084927 promotes cervical carcinogenesis by sponging miR-1179 that suppresses CDK2, a cell cycle-related gene."	hsa_circ_0084927	circ_0084927	hsa_circ_ESRP1	ESRP1	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"circ_0084927 is up-regulated in cervical cancer tissues and cell lines and acts as an oncogenic circRNA. It mainly promotes malignant phenotypes (proliferation/adhesion and cell-cycle progression, and suppresses apoptosis) by sponging miR-1179, thereby releasing CDK2 expression in a circ_0084927/miR-1179/CDK2 ceRNA axis."	0.7893
32701211	Journal of clinical laboratory analysis	2020	hsa_circ_0000520 influences herceptin resistance in gastric cancer cells through PI3K-Akt signaling pathway.	hsa_circ_0000520	circular RNA _0000520 			gastric cancer	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"In gastric cancer, hsa_circ_0000520 is down-regulated in tumors and in the Herceptin-resistant NCI-N87R cells. Forced overexpression sensitizes cells to Herceptin by suppressing proliferation and increasing apoptosis, at least partly via inhibition of PI3K/AKT signaling (reduced p-PI3K and p-Akt), which can be counteracted by IGF-1 pathway activation."	0.568
32703944	Cell death & disease	2020	Hsa_circ_0046263 functions as a ceRNA to promote nasopharyngeal carcinoma progression by upregulating IGFBP3.	hsa_circ_0046263	circ-0046263 	hsa_circ_P4HB	P4HB	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; Microarray	"circ-0046263 is up-regulated in nasopharyngeal carcinoma tissues and cell lines and promotes malignant phenotypes (proliferation, migration/invasion, EMT, and metastasis). It mainly localizes in the cytoplasm and acts as a ceRNA by sponging miR-133a-5p to increase IGFBP3 expression, thereby driving NPC progression."	0.856
32705161	International journal of oncology	2020	Novel circRNA_0071196/miRNA_19b_3p/CIT axis is associated with proliferation and migration of bladder cancer.		circRNA_0071196 			bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"circRNA_0071196 is up-regulated in bladder cancer tissues and promotes bladder cancer cell viability/proliferation and migration. Mechanistically, it functions as a ceRNA by sponging miR-19b-3p to increase CIT expression, forming a circRNA_0071196/miR-19b-3p/CIT axis with potential therapeutic/diagnostic relevance."	0.7372
32705182	Molecular medicine reports	2020	Expression profiling of circular RNAs and their potential role in early_stage diabetic cardiomyopathy.	mmu_circ_0000652				diabetic cardiomyopathy 	MONDO:0004994	cardiomyopathy	down-regulated	RT-qPCR; RNA-seq	"mmu_circ_0000652 is down-regulated in early-stage DCM mouse myocardium. It is proposed to function as a ceRNA interacting with miR-195 and thereby affect BCL2 expression, potentially promoting cardiomyocyte apoptosis."	0.2465
32705182	Molecular medicine reports	2020	Expression profiling of circular RNAs and their potential role in early_stage diabetic cardiomyopathy.	mmu_circ_0001058				diabetic cardiomyopathy 	MONDO:0004994	cardiomyopathy	down-regulated	RT-qPCR; RNA-seq	"mmu_circ_0001058 is down-regulated in early-stage DCM mouse myocardium. It is implicated as a ceRNA that interferes with miR-21 to modulate SPRY1, linking it to fibrosis-related regulation in DCM."	0.2465
32705182	Molecular medicine reports	2020	Expression profiling of circular RNAs and their potential role in early_stage diabetic cardiomyopathy.	mmu_circ_0000680				diabetic cardiomyopathy 	MONDO:0004994	cardiomyopathy	down-regulated	RT-qPCR; RNA-seq	"mmu_circ_0000680 is down-regulated in early-stage DCM mouse myocardium. The study proposes a ceRNA network involving mmu_circ_0000680/miR-30d/FOXO3A, linked to cardiomyocyte pyroptosis."	0.2465
32705182	Molecular medicine reports	2020	Expression profiling of circular RNAs and their potential role in early_stage diabetic cardiomyopathy.	mmu_circ_0000547				diabetic cardiomyopathy 	MONDO:0004994	cardiomyopathy	down-regulated	RT-qPCR; RNA-seq	mmu_circ_0000547 is down-regulated in early-stage DCM mouse myocardium. The study proposes a ceRNA network mmu_circ_0000547/miR-320/IGF-1 associated with impaired angiogenesis.	0.2465
32705182	Molecular medicine reports	2020	Expression profiling of circular RNAs and their potential role in early_stage diabetic cardiomyopathy.		novel_circ_0004285			diabetic cardiomyopathy 	MONDO:0004994	cardiomyopathy	down-regulated	RT-qPCR; RNA-seq	novel_circ_0004285 is down-regulated in early-stage DCM mouse myocardium. The study proposes a ceRNA network novel_circ_0004285/miR-451/CAB39 associated with cardiomyocyte lipotoxicity.	0.2465
32705182	Molecular medicine reports	2020	Expression profiling of circular RNAs and their potential role in early_stage diabetic cardiomyopathy.	mmu_circ_0001160		mmu_circ_ZNT7	ZNT7	diabetic cardiomyopathy 	MONDO:0004994	cardiomyopathy	up-regulated	RT-qPCR; RNA-seq	"mmu_circ_0001160 is up-regulated in early-stage DCM mouse myocardium. Computational IRES/ORF analyses suggest it may encode a polypeptide, potentially related to its host gene ZNT7, though protein translation is not experimentally validated here."	0.2465
32706154	Cancer medicine	2020	Circular RNA hsa_circRNA_102209 promotes the growth and metastasis of colorectal cancer through miR-761-mediated Ras and Rab interactor 1 signaling.		hsa_circRNA_102209 			colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Northern Blot; Microarray	"hsa_circRNA_102209 is upregulated in colorectal cancer tissues and cell lines and functions as an oncogenic circRNA. It sponges miR-761 to upregulate RIN1, thereby promoting proliferation, migration, invasion, EMT, and in vivo tumor growth/metastasis, and its high expression is associated with liver metastasis and poorer overall survival."	0.8427
32706759	Aging	2020	"Circular RNA hsa_circ_0000073 contributes to osteosarcoma cell proliferation, migration, invasion and methotrexate resistance by sponging miR-145-5p and miR-151-3p and upregulating NRAS."	hsa_circ_0000073	hsa_circ_001069	hsa_circ_OMA1	OMA1	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000073 is upregulated in osteosarcoma and promotes malignant phenotypes (proliferation, migration, invasion) and methotrexate resistance. It functions mainly in the cytoplasm as a ceRNA that binds miR-145-5p and miR-151-3p, thereby relieving repression of NRAS."	0.8595
32710445	Journal of clinical laboratory analysis	2020	Quantitative proteomics reveals the regulatory networks of circular RNA BTBD7_hsa_circ_0000563 in human coronary artery.	hsa_circ_0000563	BTBD7_hsa_circ_0000563	hsa_circ_BTBD7	BTBD7	coronary artery disease 	MONDO:0005010	coronary artery disorder	down-regulated	RT-qPCR	"BTBD7_hsa_circ_0000563 is down-regulated in severely atherosclerotic human coronary artery segments. Proteomics linked higher BTBD7_hsa_circ_0000563 levels to broad changes in mitochondrial/TCA-cycle- and oxidative-phosphorylation-related proteins, suggesting a regulatory network involving ATP synthase; miR-155-5p and miR-130a-3p binding was predicted."	0.5802
32710728	Aging	2020	Hsa_circ_0044226 knockdown attenuates progression of pulmonary fibrosis by inhibiting CDC27.	hsa_circ_0044226	hsa_circRNA_102100	hsa_circ_CDC27	CDC27	idiopathic pulmonary fibrosis 	MONDO:0800504	idiopathic pulmonary fibrosis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0044226 is upregulated in IPF lung tissues and in bleomycin-induced fibrotic mouse lungs. Its knockdown reduces TGF-beta1/BLM-induced fibrosis features by decreasing CDC27 and suppressing EMT, leading to reduced migration/proliferation changes and reduced fibrotic markers."	0.6117
32713345	Molecular cancer	2020	Exosomal circPACRGL promotes progression of colorectal cancer via the miR-142-3p/miR-506-3p- TGF-beta1 axis.	hsa_circ_0069313	circPACRGL 			colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"In colorectal cancer, exosome-associated circPACRGL is upregulated in CRC cells after tumor-derived exosome stimulation. It promotes proliferation, migration/invasion and suppresses apoptosis by sponging miR-142-3p and miR-506-3p to increase TGF-beta1 expression, and it also promotes N1-to-N2 neutrophil differentiation via the same axis."	0.6181
32714093	Cancer cell international	2020	Downregulation of circular RNA hsa_circ_0000735 boosts prostate cancer sensitivity to docetaxel via sponging miR-7.	hsa_circ_0000735		hsa_circ_P2RX1	P2RX1	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"hsa_circ_0000735 is up-regulated in docetaxel-resistant prostate cancer tissues/cells and promotes docetaxel resistance. It mainly functions as a cytoplasmic miR-7 sponge, thereby enhancing malignant behaviors and reducing apoptosis; knockdown increases docetaxel sensitivity and suppresses tumor growth in vivo. High expression is associated with shorter overall survival."	0.8571
32714095	Cancer cell international	2020	"Circular RNA ITCH suppresses proliferation, invasion, and glycolysis of ovarian cancer cells by up-regulating CDH1 via sponging miR-106a."		circ-ITCH 	hsa_circ_ITCH	ITCH	ovarian cancer	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR	"circ-ITCH is down-regulated in ovarian cancer and functions as a tumor suppressor. It sponges miR-106a to up-regulate CDH1, thereby inhibiting proliferation, invasion and glycolysis while promoting apoptosis, and it suppresses xenograft tumor growth."	0.8034
32715657	EMBO molecular medicine	2020	A Parkinson's disease CircRNAs Resource reveals a link between circSLC8A1 and oxidative stress.		circSLC8A1 	hsa_circ_SLC8A1	SLC8A1	Parkinson's disease 	MONDO:0005180	Parkinson disease	up-regulated	RT-qPCR; RNA-seq	"circSLC8A1 is up-regulated in substantia nigra of Parkinson¡¯s disease donors and is inducible by oxidative stress (paraquat) in neuronal cells. It localizes to the cytoplasm, binds Ago2, and is linked to increased expression of miR-128 target genes (e.g., BMI1, SIRT1, AXIN1), consistent with modulation of miR-128 activity in PD-related oxidative stress context."	0.717
32717723	Aging	2020	Circular RNA DHX33 promotes malignant behavior in ccRCC by targeting miR-489-3p/MEK1 axis.	hsa_circ_0000740	circDHX33	hsa_circ_DHX33	DHX33	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR; Microarray	"circDHX33 (hsa_circ_0000740), derived from DHX33, is up-regulated in ccRCC tissues and cell lines and correlates with advanced TNM stage and metastasis. Functionally, circDHX33 promotes ccRCC proliferation, invasion and in vivo tumor growth by acting as a cytoplasmic ceRNA that sponges miR-489-3p and thereby increases MEK1 expression."	0.8632
32717724	Aging	2020	Circular RNA hsa_circ_0076690 acts as a prognostic biomarker in osteoporosis and regulates osteogenic differentiation of hBMSCs via sponging miR-152.	hsa_circ_0076690				Osteoporosis 	MONDO:0005298	osteoporosis	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0076690 is down-regulated in osteoporosis patient serum/plasma and shows diagnostic potential (ROC AUC ~0.83). Mechanistically, it sponges miR-152 to modulate RUNX2 expression and promotes osteogenic differentiation of hBMSCs."	0.7938
32717724	Aging	2020	Circular RNA hsa_circ_0076690 acts as a prognostic biomarker in osteoporosis and regulates osteogenic differentiation of hBMSCs via sponging miR-152.	hsa_circ_0111433				Osteoporosis 	MONDO:0005298	osteoporosis	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0111433 is down-regulated in osteoporosis patient serum/plasma and its decreased expression was validated by RT-qPCR in clinical samples. However, it did not show acceptable diagnostic value, and no mechanism/function experiments were reported for this circRNA in the study."	0.5129
32719345	Cell death & disease	2020	HMGA2 regulates circular RNA ASPH to promote tumor growth in lung adenocarcinoma.	hsa_circ_0084606	circASPH 	hsa_circ_ASPH	ASPH	lung adenocarcinoma	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circASPH is up-regulated in lung adenocarcinoma tissues and cell lines and is associated with more advanced T/N stages and shorter overall survival. It promotes proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, it is transcriptionally regulated by HMGA2 and Twist1 and sponges miR-370 to relieve repression of HMGA2, forming an HMGA2_circASPH_HMGA2 positive feedback axis."	0.8775
32721878	Molecular therapy. Nucleic acids	2020	Circular RNA circREPS2 Acts as a Sponge of miR-558 to Suppress Gastric Cancer Progression by Regulating RUNX3/beta-catenin Signaling.	hsa_circ_0139996	circREPS2	hsa_circ_REPS2	REPS2	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"circREPS2 (hsa_circ_0139996) is down-regulated in gastric cancer tissues and cell lines and functions as a tumor suppressor. It sponges miR-558 to upregulate RUNX3, thereby inhibiting Wnt/beta-catenin signaling and suppressing proliferation, migration, invasion, EMT, and xenograft tumor growth."	0.852
32722658	Medical science monitor : international medical journal of experimental and clinical research	2020	"CircKIAA0907 Retards Cell Growth, Cell Cycle, and Autophagy of Gastric Cancer In Vitro and Inhibits Tumorigenesis In Vivo via the miR-452-5p/KAT6B Axis."	hsa_circ_0005758	circKIAA0907	hsa_circ_KIAA0907	KIAA0907	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"circKIAA0907 is downregulated in gastric cancer and mainly localizes to the cytoplasm. It suppresses GC cell proliferation, cell-cycle progression and autophagy while promoting apoptosis, and inhibits xenograft tumor growth. Mechanistically, it functions as a ceRNA by sponging miR-452-5p to upregulate KAT6B."	0.8119
32724397	Oncology letters	2020	RNAseq profiling of circRNA expression in radiation-treated A549 cells and bioinformatics analysis of radiation-related circRNA-miRNA networks.	hsa_circ_0003187		hsa_circ_ZNF827	ZNF827	lung cancer 	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0003187 is significantly up-regulated in irradiated NSCLC cells (A549; also measured in NCI-H1299) compared with non-irradiated controls. The study did not experimentally validate a specific downstream mechanism for this circRNA beyond predicted circRNA_miRNA interactions.	0.2465
32724397	Oncology letters	2020	RNAseq profiling of circRNA expression in radiation-treated A549 cells and bioinformatics analysis of radiation-related circRNA-miRNA networks.	hsa_circ_0002174	circRNA_0002174			lung cancer 	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0002174 is up-regulated in irradiated NSCLC cells and was RT-qPCR-validated. Bioinformatics network analysis predicts extensive miRNA-binding sites, suggesting a potential role in post-irradiation miRNA regulation, but specific miRNAs/targets were not experimentally confirmed."	0.2465
32724397	Oncology letters	2020	RNAseq profiling of circRNA expression in radiation-treated A549 cells and bioinformatics analysis of radiation-related circRNA-miRNA networks.	hsa_circ_0070039		hsa_circ_NUP54	NUP54	lung cancer 	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0070039 is up-regulated after irradiation in NSCLC cell lines and its differential expression was validated by RT-qPCR. No specific downstream miRNA/target or pathway was experimentally confirmed for this circRNA.	0.2465
32724397	Oncology letters	2020	RNAseq profiling of circRNA expression in radiation-treated A549 cells and bioinformatics analysis of radiation-related circRNA-miRNA networks.	hsa_circ_0004270		hsa_circ_SLC25A24	SLC25A24	lung cancer 	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0004270 is up-regulated in NSCLC cells after irradiation and its expression change was validated by RT-qPCR. The study provides only predicted circRNA_miRNA interactions without circRNA-specific mechanistic validation.	0.2465
32724397	Oncology letters	2020	RNAseq profiling of circRNA expression in radiation-treated A549 cells and bioinformatics analysis of radiation-related circRNA-miRNA networks.	hsa_circ_0005591		hsa_circ_IFT81	IFT81	lung cancer 	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0005591 is up-regulated in irradiated NSCLC cells and was RT-qPCR-validated. The study does not report circRNA-specific functional assays or a confirmed downstream axis for this circRNA.	0.2465
32724397	Oncology letters	2020	RNAseq profiling of circRNA expression in radiation-treated A549 cells and bioinformatics analysis of radiation-related circRNA-miRNA networks.	hsa_circ_0001009		hsa_circ_FANCL	FANCL	lung cancer 	MONDO:0008903	lung cancer	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0001009 is significantly down-regulated in irradiated NSCLC cell lines and was validated by RT-qPCR. The study did not establish a specific mechanistic axis for this circRNA beyond general predicted circRNA_miRNA interactions for the validated set.	0.2465
32724397	Oncology letters	2020	RNAseq profiling of circRNA expression in radiation-treated A549 cells and bioinformatics analysis of radiation-related circRNA-miRNA networks.	hsa_circ_0004815		hsa_circ_PPHLN1	PPHLN1	lung cancer 	MONDO:0008903	lung cancer	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0004815 is significantly down-regulated in irradiated NSCLC cells and was validated by RT-qPCR. No circRNA-specific functional mechanism was experimentally validated.	0.2465
32724397	Oncology letters	2020	RNAseq profiling of circRNA expression in radiation-treated A549 cells and bioinformatics analysis of radiation-related circRNA-miRNA networks.	hsa_circ_0096360		hsa_circ_SHANK2	SHANK2	lung cancer 	MONDO:0008903	lung cancer	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0096360 is significantly down-regulated in irradiated NSCLC cells and was validated by RT-qPCR. No circRNA-specific downstream pathway or target was experimentally validated.	0.2465
32724397	Oncology letters	2020	RNAseq profiling of circRNA expression in radiation-treated A549 cells and bioinformatics analysis of radiation-related circRNA-miRNA networks.	hsa_circ_0036627	circRNA_0036627	hsa_circ_PDE8A	PDE8A	lung cancer 	MONDO:0008903	lung cancer	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0036627 is down-regulated in irradiated NSCLC cells and was validated by RT-qPCR. Bioinformatics analysis predicts it has a very large number of miRNA-binding sites, implying a potential role in miRNA regulation following irradiation, but specific targets were not experimentally confirmed."	0.2465
32724397	Oncology letters	2020	RNAseq profiling of circRNA expression in radiation-treated A549 cells and bioinformatics analysis of radiation-related circRNA-miRNA networks.	hsa_circ_0004524		hsa_circ_CEP70	CEP70	lung cancer 	MONDO:0008903	lung cancer	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0004524 is significantly down-regulated in irradiated NSCLC cells and was validated by RT-qPCR. No circRNA-specific functional assays or downstream pathway were reported for this circRNA.	0.2465
32724467	Theranostics	2020	Hypoxia induced exosomal circRNA promotes metastasis of Colorectal Cancer via targeting GEF-H1/RhoA axis.	hsa_circ_0010522	Circ-133			colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"In colorectal cancer, circ-133 is up-regulated and enriched in plasma exosomes, especially under hypoxia. Hypoxia-derived exosomal circ-133 is transferred to normoxic CRC cells and promotes migration/metastasis by sponging miR-133a to enhance the GEF-H1/RhoA axis and reduce E-cadherin membrane distribution."	0.7554
32727565	BMC medical genomics	2020	Analysis of exosomal circRNAs upon irradiation in pancreatic cancer cell repopulation.	hsa_circ_0000419				pancreatic cancer	MONDO:0009831	malignant pancreatic neoplasm	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0000419 was identified as a differentially expressed exosomal circRNA in pancreatic cancer cells after irradiation, and its differential expression was validated by RT-qPCR consistent with RNA-seq results."	0.3588
32727565	BMC medical genomics	2020	Analysis of exosomal circRNAs upon irradiation in pancreatic cancer cell repopulation.	hsa_circ_0001523				pancreatic cancer	MONDO:0009831	malignant pancreatic neoplasm	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0001523 was identified as a differentially expressed exosomal circRNA in pancreatic cancer cells after irradiation, and its differential expression was validated by RT-qPCR consistent with RNA-seq results."	0.3588
32727565	BMC medical genomics	2020	Analysis of exosomal circRNAs upon irradiation in pancreatic cancer cell repopulation.	hsa_circ_0000825				pancreatic cancer	MONDO:0009831	malignant pancreatic neoplasm	dysregulated	RT-qPCR; RNA-seq	hsa_circ_0000825 is a differentially expressed exosomal circRNA after irradiation in pancreatic cancer cell exosomes; it was RT-qPCR-validated and was among the top circRNAs used to construct a predicted circRNA_miRNA_mRNA regulatory network.	0.4032
32727565	BMC medical genomics	2020	Analysis of exosomal circRNAs upon irradiation in pancreatic cancer cell repopulation.		chrM:14131_15754- 	hsa_circ_MT		pancreatic cancer	MONDO:0009831	malignant pancreatic neoplasm	dysregulated	RT-qPCR; RNA-seq	The mitochondrial-coordinate circRNA chrM:14131_15754- was identified as differentially expressed in exosomes from irradiated vs non-irradiated pancreatic cancer cells and its differential expression was validated by RT-qPCR consistent with RNA-seq.	0.3588
32727565	BMC medical genomics	2020	Analysis of exosomal circRNAs upon irradiation in pancreatic cancer cell repopulation.	hsa_circ_0002130				pancreatic cancer	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; RNA-seq	"Exosomal hsa_circ_0002130 is up-regulated after irradiation in pancreatic cancer models (cell-derived exosomes and PDX plasma exosomes). It is proposed to act as a miRNA sponge for hsa_miR_4482-3p to increase NBN expression, potentially enhancing DNA damage repair and contributing to tumor cell repopulation after radiotherapy."	0.4997
32727578	Biological research	2020	Microarray profiling and functional analysis of differentially expressed plasma exosomal circular RNAs in Graves' disease.		hsa_circRNA_000102	hsa_circ_AKNAD1	AKNAD1	Graves' disease 	MONDO:0005364	Graves disease	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_000102 is up-regulated in plasma exosomes from Graves' disease patients and was validated by RT-qPCR. Bioinformatics-based circRNA/miRNA/mRNA network and GO/KEGG analyses suggest it may participate in immune activation processes, including virus infection-related pathways and interferon-beta signaling."	0.5135
32728015	Medical science monitor : international medical journal of experimental and clinical research	2020	Identification and Expression of Several Circular RNAs and Knockdown of hsa_circ_0005556 Exerts Oncogenic Functions by miR-767-5p in Gastric Cancer.	hsa_circ_0005556	circ_0005556			Gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_0005556 is up-regulated in gastric cancer tissues/cells and acts as an oncogenic circRNA. Its knockdown increases miR-767-5p and suppresses GC cell viability, migration and invasion while promoting apoptosis; high circ_0005556 is associated with poorer prognosis and shows modest diagnostic value."	0.7779
32728015	Medical science monitor : international medical journal of experimental and clinical research	2020	Identification and Expression of Several Circular RNAs and Knockdown of hsa_circ_0005556 Exerts Oncogenic Functions by miR-767-5p in Gastric Cancer.	hsa_circ_0001013	circ_0001013			Gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_0001013 was found to be up-regulated in 20 paired gastric cancer tissues versus adjacent normal tissues by RT-qPCR, but its function/mechanism was not further investigated in this study."	0.2995
32728015	Medical science monitor : international medical journal of experimental and clinical research	2020	Identification and Expression of Several Circular RNAs and Knockdown of hsa_circ_0005556 Exerts Oncogenic Functions by miR-767-5p in Gastric Cancer.	hsa_circ_0001190	circ_0001190			Gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"circ_0001190 was found to be down-regulated in 20 paired gastric cancer tissues versus adjacent normal tissues by RT-qPCR, but was not functionally characterized in this study."	0.2995
32728015	Medical science monitor : international medical journal of experimental and clinical research	2020	Identification and Expression of Several Circular RNAs and Knockdown of hsa_circ_0005556 Exerts Oncogenic Functions by miR-767-5p in Gastric Cancer.	hsa_circ_0003195	circ_0003195			Gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"circ_0003195 was found to be down-regulated in 20 paired gastric cancer tissues versus adjacent normal tissues by RT-qPCR, but was not functionally characterized in this study."	0.2995
32728015	Medical science monitor : international medical journal of experimental and clinical research	2020	Identification and Expression of Several Circular RNAs and Knockdown of hsa_circ_0005556 Exerts Oncogenic Functions by miR-767-5p in Gastric Cancer.	hsa_circ_0001811	circ_0001811			Gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"circ_0001811 was reported as down-regulated in 20 paired gastric cancer samples, but it was not among the 6 circRNAs validated in the described RT-qPCR experiment and was not functionally characterized in this study."	0.2995
32728015	Medical science monitor : international medical journal of experimental and clinical research	2020	Identification and Expression of Several Circular RNAs and Knockdown of hsa_circ_0005556 Exerts Oncogenic Functions by miR-767-5p in Gastric Cancer.	hsa_circ_0001181	circ_0001181			Gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"circ_0001181 was validated by RT-qPCR among 6 circRNAs and showed dysregulation in gastric cancer tissues compared with adjacent normal tissues; however, its function/mechanism was not further analyzed."	0.2995
32728069	Cell death & disease	2020	CircATRNL1 promotes epithelial-mesenchymal transition in endometriosis by upregulating Yes-associated protein 1 in vitro.		hsa-circ-0020093 	hsa_circ_ATRNL1	ATRNL1	endometriosis 	MONDO:0005133	endometriosis	up-regulated	RT-qPCR	"circATRNL1 is up-regulated in ectopic endometriotic tissues and mainly localizes to the cytoplasm in Ishikawa cells. It promotes proliferation, migration, invasion and EMT by acting as a ceRNA that sponges miR-141-3p and miR-200a-3p to upregulate YAP1 in vitro."	0.7325
32729377	Technology in cancer research & treatment	2020	Circular RNA SFMBT2 Inhibits the Proliferation and Metastasis of Glioma Cells Through Mir-182-5p/Mtss1 Pathway.		circRNA SFMBT2 	hsa_circ_SFMBT2	SFMBT2	glioma	MONDO:0021042	glioma	down-regulated	RT-qPCR	"circ_SFMBT2 is down-regulated in glioma tissues and cell lines. Functionally, circ_SFMBT2 suppresses glioma cell proliferation and metastasis-related behaviors by binding miR-182-5p and relieving repression of MTSS1 (circ_SFMBT2/miR-182-5p/MTSS1 axis)."	0.6099
32729666	Journal of cellular and molecular medicine	2020	Circular RNA circ_001842 plays an oncogenic role in renal cell carcinoma by disrupting microRNA-502-5p-mediated inhibition of SLC39A14.	hsa_circ_0000328	circ_001842 			renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR; Microarray	"circ_001842 is up-regulated in renal cell carcinoma and mainly localizes to the cytoplasm. It promotes RCC proliferation, migration, invasion, EMT and xenograft tumor growth by sponging miR-502-5p and thereby increasing SLC39A14 expression; high circ_001842 expression is associated with worse patient survival."	0.8717
32729669	Journal of cellular and molecular medicine	2020	"A novel circRNA, circNUP98, a potential biomarker, acted as an oncogene via the miR-567/ PRDX3 axis in renal cell carcinoma."		circNUP98 	hsa_circ_NUP98	NUP98	renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR; Microarray	"circNUP98 is up-regulated in renal cell carcinoma and is associated with advanced stage and poor survival. It promotes RCC malignant phenotypes by sponging miR-567 to increase PRDX3, and its expression is induced by STAT3; silencing circNUP98 suppresses tumor growth and increases chemosensitivity."	0.8037
32731816	Cell transplantation	2020	Circular RNA MTO1 Inhibits the Proliferation and Invasion of Ovarian Cancer Cells Through the miR-182-5p/KLF15 Axis.		circMTO1	hsa_circ_MTO1	MTO1	ovarian cancer	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR	"circMTO1 is down-regulated in ovarian cancer tissues and cell lines and functions as a tumor suppressor by inhibiting ovarian cancer cell proliferation and invasion. It acts as a ceRNA by sponging miR-182-5p, thereby supporting KLF15 expression and suppressing ovarian cancer progression."	0.6479
32732872	Cell death & disease	2020	CircularRNA-9119 protects hepatocellular carcinoma cells from apoptosis by intercepting miR-26a/JAK1/STAT3 signaling.		circularRNA-9119 			hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ9119 is up-regulated in HCC tissues and HCC cell lines and functions as an oncogenic circRNA. It sponges miR-26a to relieve repression of JAK1, thereby promoting JAK1/STAT3 signaling, enhancing proliferation and inhibiting apoptosis; circ9119 silencing suppresses xenograft tumor growth."	0.6829
32732916	Cell death & disease	2020	Circ-GLI1 promotes metastasis in melanoma through interacting with p70S6K2 to activate Hedgehog/GLI1 and Wnt/beta-catenin pathways and upregulate Cyr61.	hsa_circ_0027247	circ-GLI1 	hsa_circ_GLI1	GLI1	melanoma 	MONDO:0005105	melanoma	up-regulated	RT-qPCR; Microarray	"circ-GLI1 (hsa_circ_0027247), derived from GLI1, is up-regulated in melanoma cells and promotes migration/invasion, metastasis, and angiogenesis. Mechanistically, it binds p70S6K2 to increase GSK3beta Ser9 phosphorylation, stabilizing GLI1 and beta-catenin proteins to activate Hedgehog/GLI1 and Wnt/beta-catenin signaling, thereby inducing MYC-driven CYR61 transcription."	0.846
32732957	Cell death & disease	2020	LEF1 mediates osteoarthritis progression through circRNF121/miR-665/MYD88 axis via NF-§ÜB signaling pathway.	hsa_circ_0023404	circRNF121	hsa_circ_RNF121	RNF121	osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"In osteoarthritis cartilage/chondrocytes, circRNF121 is up-regulated and promotes OA progression by increasing ECM degradation, inducing apoptosis, and suppressing proliferation. Mechanistically, circRNF121 acts as a ceRNA that sponges miR-665 to upregulate MYD88 and activate NF-kappaB signaling; its expression is promoted by the transcription factor LEF1."	0.7799
32733638	Oxidative medicine and cellular longevity	2020	Exosomal CircHIPK3 Released from Hypoxia-Induced Cardiomyocytes Regulates Cardiac Angiogenesis after Myocardial Infarction.		circHIPK3	mmu_circ_HIPK3	HIPK3	myocardial infarction 	MONDO:0005068	myocardial infarction	up-regulated	RT-qPCR	"This study shows that circHIPK3 is enriched in hypoxia-induced cardiomyocyte exosomes and increases in recipient cardiac endothelial cells. Exosomal circHIPK3 promotes post-MI angiogenesis by inhibiting miR-29a, upregulating VEGFA, and accelerating endothelial cell cycle progression, proliferation, migration, and tube formation."	0.6179
32733938	BioMed research international	2020	Circular RNA circFAT1(e2) Promotes Osteosarcoma Progression and Metastasis by Sponging miR-181b and Regulating HK2 Expression.		circFAT1(e2) 	hsa_circ_FAT1	FAT1	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circFAT1(e2) is up-regulated in osteosarcoma tissues/cell lines and mainly localizes to the cytoplasm. It promotes osteosarcoma cell proliferation, migration and invasion by sponging miR-181b and thereby increasing HK2 expression (circFAT1(e2)/miR-181b/HK2 ceRNA axis)."	0.6369
32742198	Cancer cell international	2020	Circ_0000190 suppresses gastric cancer progression potentially via inhibiting miR-1252/PAK3 pathway.	hsa_circ_0000190	circ_0000190			gastric cancer	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; ISH	"circ_0000190 is down-regulated in gastric cancer and mainly localized in the cytoplasm. Its overexpression suppresses gastric cancer cell growth and motility and induces apoptosis and G1 arrest, acting via a ceRNA axis where circ_0000190 sponges miR-1252 to de-repress PAK3; miR-1252 mimics attenuate these effects and PAK3 re-expression rescues them."	0.8355
32746878	Journal of experimental & clinical cancer research : CR	2020	"Circular RNA circ-CPA4/ let-7 miRNA/PD-L1 axis regulates cell growth, stemness, drug resistance and immune evasion in non-small cell lung cancer (NSCLC)."	hsa_circ_0082374	circ-CPA4 	hsa_circ_CPA4	CPA4	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ-CPA4 is upregulated in NSCLC tissues and cell lines and acts as a ceRNA sponge for let-7 miRNA, leading to increased PD-L1 (including exosomal PD-L1). This axis promotes proliferation, invasion/EMT, stemness and cisplatin resistance, and contributes to immune evasion by suppressing CD8+ T-cell activity."	0.8006
32751923	Genes	2020	Identification of circRNA-lncRNA-miRNA-mRNA Competitive Endogenous RNA Network as Novel Prognostic Markers for Acute Myeloid Leukemia.	hsa_circ_0001247				Acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	Microarray	hsa_circ_0001247 was identified as an up-regulated differentially expressed circRNA in AML and included as a hub component in an AML prognostic circRNA_lncRNA_miRNA_mRNA ceRNA network constructed via database-based target prediction.	0.1768
32751923	Genes	2020	Identification of circRNA-lncRNA-miRNA-mRNA Competitive Endogenous RNA Network as Novel Prognostic Markers for Acute Myeloid Leukemia.	hsa_circ_0012152				Acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	Microarray	hsa_circ_0012152 was identified as an up-regulated circRNA in AML and incorporated into a prognostic ceRNA network via in-silico target prediction using public datasets.	0.1768
32751923	Genes	2020	Identification of circRNA-lncRNA-miRNA-mRNA Competitive Endogenous RNA Network as Novel Prognostic Markers for Acute Myeloid Leukemia.	hsa_circ_0003602				Acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	Microarray	hsa_circ_0003602 was identified as up-regulated in AML microarray data and used as one of six hub circRNAs to build a prognostic ceRNA network through computational target prediction.	0.1768
32751923	Genes	2020	Identification of circRNA-lncRNA-miRNA-mRNA Competitive Endogenous RNA Network as Novel Prognostic Markers for Acute Myeloid Leukemia.	hsa_circ_0005571				Acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	down-regulated	Microarray	hsa_circ_0005571 was identified as a down-regulated circRNA in AML and included among six hub circRNAs forming a prognostic ceRNA network based on computational prediction.	0.1768
32751923	Genes	2020	Identification of circRNA-lncRNA-miRNA-mRNA Competitive Endogenous RNA Network as Novel Prognostic Markers for Acute Myeloid Leukemia.	hsa_circ_0007609	circ-DNAJC5	hsa_circ_DNAJC5	DNAJC5	Acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	down-regulated	Microarray	hsa_circ_0007609 (circ-DNAJC5) was found down-regulated in AML and selected as a hub circRNA used to construct an AML prognostic ceRNA network through bioinformatic analyses.	0.1768
32751923	Genes	2020	Identification of circRNA-lncRNA-miRNA-mRNA Competitive Endogenous RNA Network as Novel Prognostic Markers for Acute Myeloid Leukemia.	hsa_circ_0074371				Acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	down-regulated	Microarray	"hsa_circ_0074371 was identified as down-regulated in AML and included as a hub circRNA within the prognostic ceRNA network; the paper notes its direction differs from gastric cancer reports, suggesting context-dependent roles."	0.1768
32753964	Cancer management and research	2020	Circular RNA MYLK Promotes Glycolysis and Proliferation of Non-Small Cell Lung Cancer Cells by Sponging miR-195-5p and Increasing Glucose Transporter Member 3 Expression.		circMYLK	hsa_circ_MYLK	MYLK	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circMYLK is up-regulated in NSCLC and promotes malignant phenotypes (proliferation, migration, invasion) and glycolysis. Mechanistically, it sponges miR-195-5p to increase GLUT3 expression, and high circMYLK correlates with poor overall survival."	0.7113
32753969	Cancer management and research	2020	Circular RNA Circ_0016760 Modulates Non-Small-Cell Lung Cancer Growth Through the miR-577/ZBTB7A Axis.	hsa_circ_0016760	circ_0016760	hsa_circ_SNAP47		non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0016760 is up-regulated in NSCLC tissues and cell lines and mainly localizes to the cytoplasm. It promotes NSCLC malignant phenotypes (colony formation, migration, invasion, glycolytic activity/ECAR) and tumor growth by acting as a ceRNA that sponges miR-577, thereby increasing ZBTB7A expression."	0.7244
32756009	Aging	2020	circIQCH sponges miR-145 to promote breast cancer progression by upregulating DNMT3A expression.	hsa_circ_0104345	circIQCH	hsa_circ_IQCH	IQCH	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circIQCH (hsa_circ_0104345), derived from IQCH, is upregulated in primary and metastatic breast cancer tissues and in breast cancer cell lines. Functionally, circIQCH promotes proliferation, migration and lung metastasis. Mechanistically, circIQCH acts as a ceRNA sponge for miR-145, thereby increasing DNMT3A (and associated decreases in PTEN/BRCA1), forming a circIQCH_miR-145_DNMT3A axis."	0.84
32756532	Medical science monitor : international medical journal of experimental and clinical research	2020	Exosomes Mediated Transfer of Circ_UBE2D2 Enhances the Resistance of Breast Cancer to Tamoxifen by Binding to MiR-200a-3p.		circ_UBE2D2 	hsa_circ_UBE2D2	UBE2D2	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_UBE2D2 is up-regulated in tamoxifen-resistant breast cancer tissues/cells and is enriched in exosomes from resistant cells. Exosome-transferred circ_UBE2D2 binds miR-200a-3p and thereby promotes tamoxifen resistance, increasing cell viability and migration/invasion and modulating EMT markers and ERalpha in vitro and in xenograft tumors."	0.7581
32760224	Cancer cell international	2020	Circular RNA UBAP2 contributes to tumor growth and metastasis of cervical cancer via modulating miR-361-3p/SOX4 axis.			hsa_circ_UBAP2	UBAP2	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circUBAP2 is up-regulated in cervical cancer tissues/cell lines and its high expression is associated with poor overall survival. Functionally, circUBAP2 promotes proliferation, EMT, migration/invasion and metastasis while inhibiting apoptosis. Mechanistically, circUBAP2 acts as a ceRNA that sponges miR-361-3p to increase SOX4 expression (circUBAP2/miR-361-3p/SOX4 axis)."	0.835
32760833	Heliyon	2020	Circular RNA expression in the lungs of a mouse model of sepsis induced by cecal ligation and puncture.		circEfnb2 	mmu_circ_Efnb2	Efnb2	sepsis-induced acute lung injury 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR; RNA-seq	"In CLP-induced sepsis-associated acute lung injury in mice, circEfnb2 is up-regulated in lung tissue and is predicted (via TargetScan/miRanda) to sponge mmu-miR-340-5p, suggesting a potential ceRNA-type regulatory role in sepsis-related lung inflammation."	0.5922
32760833	Heliyon	2020	Circular RNA expression in the lungs of a mouse model of sepsis induced by cecal ligation and puncture.		circWdr49 	mmu_circ_Wdr49	Wdr49	sepsis-induced acute lung injury 	MONDO:0005229	bacterial infectious disease with sepsis	down-regulated	RT-qPCR; RNA-seq	"In CLP-induced sepsis-associated acute lung injury in mice, circWdr49 is down-regulated in lung tissue and is predicted to bind mmu-miR-34b-5p; the authors discuss a possible connection to miR-34b-5p/PGRN-related modulation of inflammation and apoptosis, though functional validation is not performed."	0.5922
32764824	PLoS pathogens	2020	Host-derived circular RNAs display proviral activities in Hepatitis C virus-infected cells.		circPSD3 	hsa_circ_PSD3	PSD3	Hepatitis C virus infection 	MONDO:0005231	hepatitis C virus infection	up-regulated	RT-qPCR; RNA-seq	"circPSD3 is up-regulated in HCV-infected liver cells and functions as a pro-viral factor that increases HCV RNA abundance; it also promotes DENV infectivity. Mechanistically, it binds eIF4A3 and can modulate NMD substrates, but its pro-viral effect occurs mainly at a post-translational step and is independent of eIF4A3¡¯s antiviral NMD-related effects."	0.6913
32764824	PLoS pathogens	2020	Host-derived circular RNAs display proviral activities in Hepatitis C virus-infected cells.		circEXOSC 	hsa_circ_EXOSC		Hepatitis C virus infection 	MONDO:0005231	hepatitis C virus infection	up-regulated	RT-qPCR; RNA-seq	"circEXOSC is up-regulated during HCV infection in Huh7 cells, and siRNA knockdown of its back-splice junction reduces HCV infectivity, supporting a pro-viral role."	0.4851
32764824	PLoS pathogens	2020	Host-derived circular RNAs display proviral activities in Hepatitis C virus-infected cells.		circTIAL	hsa_circ_TIAL1	TIAL1	Hepatitis C virus infection 	MONDO:0005231	hepatitis C virus infection	up-regulated	RT-qPCR; RNA-seq	"circTIAL (from TIAL1) is up-regulated during HCV infection, and siRNA knockdown of its back-splice junction reduces HCV infectivity, indicating a pro-viral role."	0.4851
32764965	OncoTargets and therapy	2020	RNA-Seq Profiling of Circular RNAs and the Oncogenic Role of circPVT1 in Cutaneous Squamous Cell Carcinoma.	hsa_circ_0001821	circPVT1 	hsa_circ_PVT1	PVT1	Cutaneous squamous cell carcinoma 	MONDO:0002529	skin squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circPVT1 (hsa_circ_0001821) is up-regulated in CSCC tissues and CSCC cell lines. Loss-of-function (siRNA knockdown) inhibits proliferation, migration and invasion and increases apoptosis, supporting an oncogenic role; miRNA-sponging interactions were bioinformatically predicted (notably hsa-miR-587) but not experimentally validated."	0.7477
32765068	Cancer management and research	2020	Circular RNA ITCH Suppresses Cell Proliferation but Induces Apoptosis in Oral Squamous Cell Carcinoma by Regulating miR-421/PDCD4 Axis.			hsa_circ_ITCH	ITCH	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR	"circ-ITCH is down-regulated in OSCC tissues and cell lines and functions as a tumor suppressor. It mainly localizes to the cytoplasm and acts as a ceRNA to sponge miR-421, relieving miR-421-mediated repression of PDCD4, thereby inhibiting proliferation and promoting apoptosis in OSCC cells."	0.7325
32765095	Cancer management and research	2020	circ-NRIP1 Promotes Glycolysis and Tumor Progression by Regulating miR-186-5p/MYH9 Axis in Gastric Cancer.		circ-NRIP1 	hsa_circ_NRIP1	NRIP1	Gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"In gastric cancer, circ-NRIP1 is up-regulated and promotes proliferation, migration, glycolysis and tumor growth while suppressing apoptosis. Mechanistically, circ-NRIP1 sponges miR-186-5p to increase MYH9 expression, which contributes to glycolytic activation (e.g., HK2/PKM2) and tumor progression."	0.6536
32765789	Oncology letters	2020	Circular RNA profiling in plasma exosomes from patients with gastric cancer.	hsa_circ_0093425		hsa_circ_ANKRD26	ANKRD26	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RNA-seq	hsa_circ_0093425 was identified by RNA-seq as an upregulated circRNA in plasma exosomes from patients with gastric cancer compared with healthy controls. No circRNA-specific mechanism or function was experimentally validated for this circRNA in this study.	0.1155
32765789	Oncology letters	2020	Circular RNA profiling in plasma exosomes from patients with gastric cancer.	hsa_circ_0007247		hsa_circ_TBCE	TBCE	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RNA-seq	hsa_circ_0007247 was identified by RNA-seq as an upregulated circRNA in plasma exosomes from patients with gastric cancer compared with healthy controls. The study did not provide circRNA-specific functional/mechanistic validation for this circRNA.	0.1155
32765789	Oncology letters	2020	Circular RNA profiling in plasma exosomes from patients with gastric cancer.	hsa_circ_0029780		hsa_circ_MTMR6	MTMR6	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RNA-seq	hsa_circ_0029780 was identified by RNA-seq as upregulated in plasma exosomes from gastric cancer patients versus healthy controls. The study did not report circRNA-specific functional or mechanistic experiments for this circRNA.	0.1155
32765789	Oncology letters	2020	Circular RNA profiling in plasma exosomes from patients with gastric cancer.	hsa_circ_0139983		hsa_circ_REPS2	REPS2	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RNA-seq	hsa_circ_0139983 was identified by RNA-seq as downregulated in plasma exosomes from gastric cancer patients versus healthy controls. The study did not provide circRNA-specific functional/mechanistic validation for this circRNA.	0.1155
32765789	Oncology letters	2020	Circular RNA profiling in plasma exosomes from patients with gastric cancer.	hsa_circ_0001989		hsa_circ_SPG20	SPG20	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RNA-seq	hsa_circ_0001989 was identified by RNA-seq as downregulated in plasma exosomes from gastric cancer patients compared with healthy controls. No circRNA-specific functional or mechanistic validation was reported for this circRNA.	0.1155
32765789	Oncology letters	2020	Circular RNA profiling in plasma exosomes from patients with gastric cancer.	hsa_circ_0011115		hsa_circ_EYA3	EYA3	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RNA-seq	hsa_circ_0011115 was identified by RNA-seq as downregulated in plasma exosomes from gastric cancer patients versus healthy controls. The paper did not report specific downstream miRNAs/mRNAs or functional assays for this circRNA.	0.1155
32765789	Oncology letters	2020	Circular RNA profiling in plasma exosomes from patients with gastric cancer.	hsa_circ_0019618		hsa_circ_MGEA5	MGEA5	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RNA-seq	hsa_circ_0019618 was identified by RNA-seq as downregulated in plasma exosomes from gastric cancer patients compared with healthy controls. The study provided no circRNA-specific functional/mechanistic validation for this circRNA.	0.1155
32766125	Frontiers in oncology	2020	CircRNA circ_POLA2 Promotes Cervical Squamous Cell Carcinoma Progression via Regulating miR-326/GNB1.	hsa_circ_0022812	circ_POLA2	hsa_circ_POLA2	POLA2	cervical squamous cell carcinoma 	MONDO:0006143	cervical squamous cell carcinoma	up-regulated	RT-qPCR; ISH	"circ_POLA2 is up-regulated in CESC and associated with poor prognosis. It promotes cervical cancer proliferation, migration/invasion and metastasis by acting as a ceRNA that sponges miR-326, leading to increased GNB1 and activation of ERK signaling."	0.8427
32766708	Bioscience reports	2020	Circ_0000144 functions as a miR-623 sponge to enhance gastric cancer progression via up-regulating GPRC5A.	hsa_circ_0000144	circ_0000144 	hsa_circ_SLAMF6	SLAMF6	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_0000144 is up-regulated in gastric cancer and promotes malignant phenotypes and glutaminolysis while inhibiting apoptosis. Mechanistically, it functions as a ceRNA by sponging miR-623 to up-regulate GPRC5A, and its knockdown suppresses xenograft tumor growth."	0.6831
32767499	Thoracic cancer	2020	Circular RNA CirCHIPK3 promotes cell proliferation and invasion of breast cancer by sponging miR-193a/HMGB1/PI3K/AKT axis.	hsa_circ_0000284	CirCHIPK3 	hsa_circ_HIPK3	HIPK3	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"CirCHIPK3 is up-regulated in breast cancer and is associated with worse overall survival. Functionally, it promotes proliferation, migration, invasion and xenograft tumor growth by sponging miR-193a to increase HMGB1 and activate the HMGB1/PI3K/AKT pathway."	0.8008
32774154	Cancer cell international	2020	Circular RNA hsa_circ_0000517 modulates hepatocellular carcinoma advancement via the miR-326/SMAD6 axis.	hsa_circ_0000517		hsa_circ_RPPH1	RPPH1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"In hepatocellular carcinoma, hsa_circ_0000517 is up-regulated and functions as an oncogenic circRNA by promoting proliferation, cell-cycle progression, migration/invasion, and xenograft tumor growth. Mechanistically, it acts as a ceRNA that sponges miR-326 to increase SMAD6, forming a hsa_circ_0000517/miR-326/SMAD6 regulatory axis associated with poor patient survival."	0.8006
32774168	Cancer cell international	2020	"CircPOSTN/miR-361-5p/TPX2 axis regulates cell growth, apoptosis and aerobic glycolysis in glioma cells."		circPOSTN	hsa_circ_POSTN	POSTN	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circPOSTN is upregulated in glioma tissues/cells and promotes proliferation, tumor growth and aerobic glycolysis while suppressing apoptosis. It functions as a ceRNA to sponge miR-361-5p, thereby increasing TPX2 expression and driving the circPOSTN/miR-361-5p/TPX2 regulatory axis."	0.6521
32775413	BioMed research international	2020	Circular RNA circHIPK3 Promotes Cell Metastasis through miR-637/STAT3 Axis in Osteosarcoma.		circHIPK3	hsa_circ_HIPK3	HIPK3	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in osteosarcoma tissues and cell lines and promotes osteosarcoma cell proliferation, migration, and invasion. Mechanistically, it mainly localizes in the cytoplasm and functions as a miR-637 sponge to de-repress STAT3, forming a circHIPK3/miR-637/STAT3 regulatory axis with potential prognostic/therapeutic relevance."	0.6676
32782238	Medical science monitor : international medical journal of experimental and clinical research	2020	"A Regulatory Axis of circ_0008193/miR-1180-3p/TRIM62 Suppresses Proliferation, Migration, Invasion, and Warburg Effect in Lung Adenocarcinoma Cells Under Hypoxia."	hsa_circ_0008193	circ_0008193	hsa_circ_FAM120A	FAM120A	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR	"hsa_circ_0008193 (circ_0008193), derived from FAM120A, is down-regulated in LUAD tissues and cell lines, further decreased under hypoxia. Its overexpression suppresses proliferation, migration/invasion, and glycolysis (Warburg effect) in hypoxic LUAD cells and inhibits xenograft growth by sponging miR-1180-3p to upregulate TRIM62."	0.7843
32782441	Cancer cell international	2020	Circ_0007841 promotes the progression of multiple myeloma through targeting miR-338-3p/BRD4 signaling cascade.	hsa_circ_0007841	circ_0007841			multiple myeloma 	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR	"circ_0007841 is up-regulated in multiple myeloma plasma cells and MM cell lines and acts as an oncogenic circRNA. It sponges miR-338-3p to increase BRD4 expression, thereby promoting PI3K/AKT activation and enhancing proliferation, cell-cycle progression, migration/invasion while suppressing apoptosis; MSC-derived exosomes can further enhance MM malignancy via circ_0007841."	0.6831
32785098	Cells	2020	circRNAome Profiling in Oral Carcinoma Unveils a Novel circFLNB that Mediates Tumour Growth-Regulating Transcriptional Response.		circFLNB	hsa_circ_FLNB	FLNB	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circFLNB is up-regulated in OSCC tumors and functions as a pro-tumorigenic circRNA that promotes proliferation, survival under doxorubicin stress, migration/invasion, and xenograft tumor growth. Mechanistically, the study proposes a ceRNA axis involving circFLNB and miR-9-5p with shared targeting of downstream genes such as SLC7A8 and ZNF618, supported by RNA-seq/co-expression and knockdown transcriptome profiling."	0.7634
32785098	Cells	2020	circRNAome Profiling in Oral Carcinoma Unveils a Novel circFLNB that Mediates Tumour Growth-Regulating Transcriptional Response.		circSNX5	hsa_circ_SNX5		oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RNA-seq	"circSNX5 was identified from OSCC tumor vs adjacent normal RNA-seq data and showed elevated expression in tumors; its existence and tumor-associated differential expression were supported by divergent-primer PCR and Sanger sequencing, but no further functional or mechanistic characterization was reported."	0.385
32785098	Cells	2020	circRNAome Profiling in Oral Carcinoma Unveils a Novel circFLNB that Mediates Tumour Growth-Regulating Transcriptional Response.		circABCA6	hsa_circ_ABCA6		oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RNA-seq	"circABCA6 was identified from OSCC tumor vs adjacent normal RNA-seq data and showed reduced expression in tumors; its existence and tumor-associated differential expression were supported by divergent-primer PCR and Sanger sequencing, but no further functional or mechanistic characterization was reported."	0.385
32785098	Cells	2020	circRNAome Profiling in Oral Carcinoma Unveils a Novel circFLNB that Mediates Tumour Growth-Regulating Transcriptional Response.		circBNC2	hsa_circ_BNC2		oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RNA-seq	"circBNC2 was identified from OSCC tumor vs adjacent normal RNA-seq data and showed reduced expression in tumors; its existence and tumor-associated differential expression were supported by divergent-primer PCR and Sanger sequencing, but no further functional or mechanistic characterization was reported."	0.385
32787581	Cell transplantation	2020	Circular RNA hsa_Circ_101141 as a Competing Endogenous RNA Facilitates Tumorigenesis of Hepatocellular Carcinoma by Regulating miR-1297/ROCK1 Pathway.		hsa_Circ_101141	hsa_circ_ANAPC7	ANAPC7	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH	"circ_101141 (circular ANAPC7) is up-regulated in HCC tissues and cell lines and is associated with worse overall survival. Functionally, circ_101141 promotes proliferation, cell-cycle progression, migration/invasion, and in vivo xenograft tumor growth. Mechanistically, it acts as a ceRNA sponging miR-1297 to increase ROCK1 expression."	0.8457
32788609	Scientific reports	2020	Construct a circRNA/miRNA/mRNA regulatory network to explore potential pathogenesis and therapy options of clear cell renal cell carcinoma.	hsa_circ_0029340	hsa_circRNA_101202	hsa_circ_SCARB1	SCARB1	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	Microarray	"hsa_circ_0029340 is up-regulated in ccRCC (microarray) and was used to construct a predicted ceRNA network. It was predicted to sponge miR-1205 and miR-657, forming an axis such as hsa_circ_0029340/miR-657/GRM4."	0.1768
32788609	Scientific reports	2020	Construct a circRNA/miRNA/mRNA regulatory network to explore potential pathogenesis and therapy options of clear cell renal cell carcinoma.	hsa_circ_0039238	hsa_circRNA_039238	hsa_circ_NETO2	NETO2	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	Microarray	"hsa_circ_0039238 is up-regulated in ccRCC (microarray) and was incorporated into a predicted circRNA/miRNA/mRNA network. It was predicted to bind miR-1278 and miR-548p and connect to targets including PTGER3, HAPLN1, CXCL5, MCHR1, and CXCR4 via miR-548p."	0.1768
32788609	Scientific reports	2020	Construct a circRNA/miRNA/mRNA regulatory network to explore potential pathogenesis and therapy options of clear cell renal cell carcinoma.	hsa_circ_0025135	hsa_circRNA_101001	hsa_circ_SCNN1A	SCNN1A	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	down-regulated	Microarray	"hsa_circ_0025135 is down-regulated in ccRCC (microarray) and was included in a predicted circRNA/miRNA/mRNA network. It was predicted to sponge miR-587 and miR-637 and link to multiple hub genes including PTGER3, ADCY2, ACKR3, NPY5R, APLN, GRM4 and MTNR1B."	0.1768
32788609	Scientific reports	2020	Construct a circRNA/miRNA/mRNA regulatory network to explore potential pathogenesis and therapy options of clear cell renal cell carcinoma.	hsa_circ_0031594	hsa_circRNA_101341	hsa_circ_EGLN3	EGLN3	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	Microarray	"hsa_circ_0031594 is up-regulated in ccRCC based on microarray analysis, but no circRNA_miRNA interactions were identified for it in this study. Its functional mechanism in ccRCC remains unspecified and is only discussed as possibly acting via non-ceRNA roles."	0.1768
32788609	Scientific reports	2020	Construct a circRNA/miRNA/mRNA regulatory network to explore potential pathogenesis and therapy options of clear cell renal cell carcinoma.	hsa_circ_0084927	hsa_circRNA_104651	hsa_circ_ESRP1	ESRP1	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	down-regulated	Microarray	"hsa_circ_0084927 is down-regulated in ccRCC based on microarray analysis, but no predicted miRNA interactions were found for it in the constructed ceRNA network. Its role in ccRCC remains unspecified in this study."	0.1768
32788609	Scientific reports	2020	Construct a circRNA/miRNA/mRNA regulatory network to explore potential pathogenesis and therapy options of clear cell renal cell carcinoma.	hsa_circ_0035442	hsa_circRNA_101529	hsa_circ_ALDH1A2	ALDH1A2	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	down-regulated	Microarray	"hsa_circ_0035442 is down-regulated in ccRCC based on microarray analysis, but it was not connected to predicted miRNAs in the ceRNA network. The study does not specify its functional mechanism in ccRCC."	0.1768
32791450	Molecular therapy. Nucleic acids	2020	Circular RNA circTNPO3 Regulates Paclitaxel Resistance of Ovarian Cancer Cells by miR-1299/NEK2 Signaling Pathway.	hsa_circ_0001741	circTNPO3	hsa_circ_TNPO3	TNPO3	ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; Microarray	"circTNPO3 (hsa_circ_0001741) is upregulated in ovarian cancer, especially in paclitaxel-resistant tumors and cell lines. It promotes paclitaxel resistance by acting as a cytoplasmic ceRNA that sponges miR-1299, thereby increasing NEK2 expression and reducing PTX-induced apoptosis; high expression is associated with poorer overall survival and shows diagnostic value in tissues."	0.8919
32792505	Cell death & disease	2020	The circular RNA circ-GRB10 participates in the molecular circuitry inhibiting human intervertebral disc degeneration.		circ-GRB10 	hsa_circ_GRB10	GRB10	intervertebral disc degeneration 	MONDO:0011385	intervertebral disk degenerative disorder	down-regulated	RT-qPCR	"circ-GRB10 is down-regulated in IDD and exerts protective effects by promoting ECM anabolism (collagen II, aggrecan) and inhibiting catabolic enzymes (MMP-13, ADAMT-5) in NP cells. Mechanistically, it sponges miR-328-5p to sustain ERBB2 and ERK signaling, while its biogenesis is promoted by the RBP FUS, which is suppressed by miR-141-3p, forming an ERBB2/ERK/miR-141-3p/FUS/circ-GRB10 feedback circuit; intradiscal delivery alleviates rat IDD."	0.7939
32792549	Scientific reports	2020	Upregulation of circ_0000199 in circulating exosomes is associated with survival outcome in OSCC.	hsa_circ_0000199	circ_0000199	hsa_circ_AKT3	AKT3	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circ_0000199 is up-regulated in circulating (serum) exosomes of OSCC patients and its high level predicts worse OS and DFS and higher recurrence/mortality. Functionally, circ_0000199 promotes OSCC cell proliferation and inhibits apoptosis, and is predicted to sponge miR-145-5p/miR-29b-3p to affect downstream targets (e.g., CPEB3, PAN2, RLIM, CFL2) and pathways including ECM-receptor interaction and TGF-beta signaling."	0.6304
32796815	Cell death & disease	2020	Circular noncoding RNA circMBOAT2 is a novel tumor marker and regulates proliferation/migration by sponging miR-519d-3p in colorectal cancer.	hsa_circ_0007334	circMBOAT2	hsa_circ_MBOAT2	MBOAT2	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"circMBOAT2 (hsa_circ_0007334), derived from MBOAT2, is up-regulated in colorectal cancer tissues and patient serum and is associated with tumor stage. It promotes CRC cell proliferation, migration, invasion and tumor growth by acting as a miRNA sponge for miR-519d-3p, thereby upregulating TROAP. It shows diagnostic value (ROC) and high expression predicts poor overall survival, serving as an independent prognostic marker."	0.8766
32796851	Nature communications	2020	An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution.		circKCNT2	hsa_circ_KCNT2	KCNT2	innate colitis 	MONDO:0005292	colitis	up-regulated	RT-qPCR; Northern Blot; ISH; Microarray	"In mouse ILC3s during intestinal inflammation, circKcnt2 is induced and localizes to the nucleus. It directly associates with Mbd3/NuRD and is enriched at the Batf promoter to repress Batf transcription, reducing IL-17 production and limiting ILC3 activation, thereby facilitating colitis resolution."	0.7701
32796851	Nature communications	2020	An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution.	mmu_circ_0000084	circKcnt2 	mmu_circ_Kcnt2	Kcnt2	innate colitis 	MONDO:0005292	colitis	up-regulated	RT-qPCR; Northern Blot; ISH; Microarray	"In mouse ILC3s during intestinal inflammation, circKcnt2 is induced and localizes to the nucleus. It directly associates with Mbd3/NuRD and is enriched at the Batf promoter to repress Batf transcription, reducing IL-17 production and limiting ILC3 activation, thereby facilitating colitis resolution."	0.7701
32799891	Journal of experimental & clinical cancer research : CR	2020	CircTADA2A suppresses the progression of colorectal cancer via miR-374a-3p/KLF14 axis.		circTADA2A 	hsa_circ_TADA2A	TADA2A	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	"CircTADA2A is down-regulated in colorectal cancer and mainly localized in the cytoplasm. It suppresses CRC progression by sponging miR-374a-3p to up-regulate KLF14, thereby inhibiting cell cycle progression and glycolysis and promoting apoptosis, and it reduces tumor growth in xenograft models."	0.7328
32801258	The Journal of reproduction and development	2020	CircPlekha7 plays an anti-fibrotic role in intrauterine adhesions by modulating endometrial stromal cell proliferation and apoptosis.		chr1:185495031|185495489	rno_circ_Plekha7	PLEKHA7	intrauterine adhesions 	MONDO:0001809	adhesions of uterus	up-regulated	RT-qPCR; RNA-seq	"In a TGF-beta1-induced rat endometrial stromal cell IUA fibrosis model, circPlekha7 is upregulated in the SIS3-treated (fibrosis-reversed) condition. Functionally, circPlekha7 promotes ESC apoptosis, reduces cell viability, and suppresses fibrosis markers (alpha-SMA, collagen I) and SMAD3/pSMAD3. Mechanistically, it is linked to a ceRNA relationship with rno-miR-207 and the anti-fibrotic gene Csf1."	0.6528
32801782	OncoTargets and therapy	2020	Circular RNA circLPAR3 Facilitates Esophageal Squamous Cell Carcinoma Progression Through Upregulating HMGB1 via Sponging miR-375/miR-433.	hsa_circ_0004390	circLPAR3	hsa_circ_LPAR3	LPAR3	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"circLPAR3 is up-regulated in ESCC tissues/cells and mainly localizes to the cytoplasm. It promotes ESCC proliferation, migration, invasion and xenograft tumor growth by sponging miR-375 and miR-433, thereby relieving repression of HMGB1. High circLPAR3 expression is associated with poorer overall survival in ESCC patients."	0.8034
32801783	OncoTargets and therapy	2020	Circular RNA ZNF609 Promoted Hepatocellular Carcinoma Progression by Upregulating PAP2C Expression via Sponging miR-342-3p.		CircZNF609 	hsa_circ_ZNF609	ZNF609	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH	"circZNF609 is upregulated in hepatocellular carcinoma and is associated with poor clinical outcomes. Functionally, it promotes HCC cell proliferation/viability, migration and invasion while suppressing apoptosis, and it enhances tumor growth in a HepG2 xenograft model. Mechanistically, it acts as a ceRNA sponge for miR-324-3p to increase RAP2C expression."	0.7829
32801884	Cancer management and research	2020	Circ_0000885 Enhances Osteosarcoma Progression by Increasing FGFR1 Expression via Sponging MiR-1294.	hsa_circ_0000885	circ_0000885			osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ_0000885 is up-regulated in osteosarcoma tissues and cell lines and promotes malignant phenotypes (proliferation, migration/invasion, and cell-cycle progression) as well as tumor growth in vivo. Mechanistically, it functions as a ceRNA by sponging miR-1294 to increase FGFR1 expression."	0.6542
32801908	Cancer management and research	2020	CircEPSTI1 Promotes the Progression of Non-Small Cell Lung Cancer Through miR-145/HMGB3 Axis.		circEPSTI1 	hsa_circ_EPSTI1	EPSTI1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circEPSTI1 is up-regulated in NSCLC tissues/cells and its high level correlates with worse survival. Functionally, circEPSTI1 promotes NSCLC proliferation and metastasis-related behaviors and enhances tumor growth in vivo by sponging miR-145 to derepress HMGB3."	0.7583
32801909	Cancer management and research	2020	Circ_0046599 Promotes the Development of Hepatocellular Carcinoma by Regulating the miR-1258/RPN2 Network.	hsa_circ_0046599	circ_0046599			hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0046599 is up-regulated in HCC tissues and cell lines and is mainly localized in the cytoplasm. It promotes HCC malignant phenotypes (proliferation, migration/invasion and glycolysis) and tumor growth by sponging miR-1258 to increase RPN2 expression."	0.8174
32801999	Mediators of inflammation	2020	Comprehensive Analysis of a circRNA-miRNA-mRNA Network to Reveal Potential Inflammation-Related Targets for Gastric Adenocarcinoma.	hsa_circ_0001866				gastric cancer 	MONDO:0001056	gastric cancer	dysregulated	Microarray	"This study¡¯s constructed ceRNA network suggests hsa_circ_0001866 may act as a miRNA sponge for hsa-miR-421, thereby potentially affecting COL4A1 regulation in gastric cancer/gastric adenocarcinoma. The evidence is based on microarray differential expression and bioinformatics interaction predictions without experimental validation."	0.1768
32801999	Mediators of inflammation	2020	Comprehensive Analysis of a circRNA-miRNA-mRNA Network to Reveal Potential Inflammation-Related Targets for Gastric Adenocarcinoma.	hsa_circ_0003192				gastric cancer 	MONDO:0001056	gastric cancer	dysregulated	Microarray	The bioinformatics-derived ceRNA network indicates hsa_circ_0003192 may sponge hsa-miR-421 and thereby be linked to regulation of COL4A1 in gastric cancer/gastric adenocarcinoma. No wet-lab validation was reported for this circRNA.	0.1768
32801999	Mediators of inflammation	2020	Comprehensive Analysis of a circRNA-miRNA-mRNA Network to Reveal Potential Inflammation-Related Targets for Gastric Adenocarcinoma.	hsa_circ_0055521				gastric cancer 	MONDO:0001056	gastric cancer	dysregulated	Microarray	"In the inferred ceRNA network, hsa_circ_0055521 is proposed to interact with hsa-miR-567 and be connected to THBS1 and IGFBP5 regulation in gastric cancer. This is supported by microarray-based differential expression and computational interaction prediction only."	0.1768
32801999	Mediators of inflammation	2020	Comprehensive Analysis of a circRNA-miRNA-mRNA Network to Reveal Potential Inflammation-Related Targets for Gastric Adenocarcinoma.	hsa_circ_0005217				gastric cancer 	MONDO:0001056	gastric cancer	dysregulated	Microarray	The study¡¯s bioinformatics ceRNA network links hsa_circ_0005217 with hsa-miR-648 and the downstream mRNAs THBS1 and CALM1 in gastric cancer. This association is computational and lacks experimental validation in the paper.	0.1768
32801999	Mediators of inflammation	2020	Comprehensive Analysis of a circRNA-miRNA-mRNA Network to Reveal Potential Inflammation-Related Targets for Gastric Adenocarcinoma.	hsa_circ_0004370				gastric cancer 	MONDO:0001056	gastric cancer	dysregulated	Microarray	This paper¡¯s ceRNA network analysis associates hsa_circ_0004370 with hsa-miR-648 and downstream THBS1/CALM1 in gastric cancer. The finding is bioinformatics-based with no direct experimental confirmation reported.	0.1768
32801999	Mediators of inflammation	2020	Comprehensive Analysis of a circRNA-miRNA-mRNA Network to Reveal Potential Inflammation-Related Targets for Gastric Adenocarcinoma.	hsa_circ_0007094				gastric cancer 	MONDO:0001056	gastric cancer	dysregulated	Microarray	"The constructed ceRNA network proposes that hsa_circ_0007094 may sponge hsa-miR-140-3p and/or hsa-miR-1205, linking it to FN1 and THBS1 regulation in gastric cancer. This is based on microarray DE results and in-silico predictions only."	0.1768
32801999	Mediators of inflammation	2020	Comprehensive Analysis of a circRNA-miRNA-mRNA Network to Reveal Potential Inflammation-Related Targets for Gastric Adenocarcinoma.	hsa_circ_0013048				gastric cancer 	MONDO:0001056	gastric cancer	dysregulated	Microarray	"The bioinformatics ceRNA network links hsa_circ_0013048 to hsa-miR-140-3p and FN1 in gastric cancer, suggesting a potential miRNA-sponge regulatory role. No experimental validation is provided."	0.1768
32801999	Mediators of inflammation	2020	Comprehensive Analysis of a circRNA-miRNA-mRNA Network to Reveal Potential Inflammation-Related Targets for Gastric Adenocarcinoma.	hsa_circ_0008615				gastric cancer 	MONDO:0001056	gastric cancer	dysregulated	Microarray	The paper¡¯s ceRNA network analysis suggests hsa_circ_0008615 may sponge hsa-miR-140-3p and be connected to FN1 in gastric cancer. Evidence is limited to differential-expression microarray data and in-silico predictions.	0.1768
32801999	Mediators of inflammation	2020	Comprehensive Analysis of a circRNA-miRNA-mRNA Network to Reveal Potential Inflammation-Related Targets for Gastric Adenocarcinoma.	hsa_circ_0002570				gastric cancer 	MONDO:0001056	gastric cancer	dysregulated	Microarray	"The study suggests, via a ceRNA network, that hsa_circ_0002570 could interact with hsa-miR-140-3p and relate to FN1 regulation in gastric cancer. Evidence is limited to computational analysis of microarray datasets."	0.1768
32801999	Mediators of inflammation	2020	Comprehensive Analysis of a circRNA-miRNA-mRNA Network to Reveal Potential Inflammation-Related Targets for Gastric Adenocarcinoma.	hsa_circ_0001789				gastric cancer 	MONDO:0001056	gastric cancer	dysregulated	Microarray	"The ceRNA network analysis links hsa_circ_0001789 to hsa-miR-140-3p and FN1 in gastric cancer, implying a potential miRNA sponge role. This is not experimentally validated in the study."	0.1768
32801999	Mediators of inflammation	2020	Comprehensive Analysis of a circRNA-miRNA-mRNA Network to Reveal Potential Inflammation-Related Targets for Gastric Adenocarcinoma.	hsa_circ_0004339				gastric cancer 	MONDO:0001056	gastric cancer	dysregulated	Microarray	"The paper¡¯s ceRNA network links hsa_circ_0004339 to hsa-miR-1205 and THBS1 in gastric cancer, implying a possible sponge-mediated regulatory relationship derived from bioinformatics analysis."	0.1768
32801999	Mediators of inflammation	2020	Comprehensive Analysis of a circRNA-miRNA-mRNA Network to Reveal Potential Inflammation-Related Targets for Gastric Adenocarcinoma.	hsa_circ_0007613				gastric cancer 	MONDO:0001056	gastric cancer	dysregulated	Microarray	"The study links hsa_circ_0007613 to a predicted hsa-miR-1205/THBS1 ceRNA axis in gastric cancer via bioinformatics analysis of GEO microarrays and interaction databases, without experimental validation."	0.1768
32801999	Mediators of inflammation	2020	Comprehensive Analysis of a circRNA-miRNA-mRNA Network to Reveal Potential Inflammation-Related Targets for Gastric Adenocarcinoma.	hsa_circ_0007404				gastric cancer 	MONDO:0001056	gastric cancer	dysregulated	Microarray	The bioinformatics ceRNA network suggests hsa_circ_0007404 may regulate CTGF via sponging hsa-miR-375 in gastric cancer. The study provides computational evidence only (microarray + database predictions).	0.1768
32801999	Mediators of inflammation	2020	Comprehensive Analysis of a circRNA-miRNA-mRNA Network to Reveal Potential Inflammation-Related Targets for Gastric Adenocarcinoma.	hsa_circ_0051246				gastric cancer 	MONDO:0001056	gastric cancer	dysregulated	Microarray	"The study¡¯s computational ceRNA network associates hsa_circ_0051246 with hsa-miR-375 and CTGF in gastric cancer, suggesting a potential regulatory axis without experimental validation."	0.1768
32801999	Mediators of inflammation	2020	Comprehensive Analysis of a circRNA-miRNA-mRNA Network to Reveal Potential Inflammation-Related Targets for Gastric Adenocarcinoma.	hsa_circ_0045602				gastric cancer 	MONDO:0001056	gastric cancer	dysregulated	Microarray	"The study¡¯s ceRNA network analysis associates hsa_circ_0045602 with hsa-miR-375 and CTGF in gastric cancer, suggesting a potential sponge-based regulatory axis inferred from bioinformatics."	0.1768
32801999	Mediators of inflammation	2020	Comprehensive Analysis of a circRNA-miRNA-mRNA Network to Reveal Potential Inflammation-Related Targets for Gastric Adenocarcinoma.	hsa_circ_0031027				gastric cancer 	MONDO:0001056	gastric cancer	dysregulated	Microarray	"The ceRNA network associates hsa_circ_0031027 with hsa-miR-375 and CTGF in gastric cancer, implying a potential circRNA-miRNA-mRNA regulatory relationship based on bioinformatics analysis."	0.1768
32802182	Theranostics	2020	CircCDK14 protects against Osteoarthritis by sponging miR-125a-5p and promoting the expression of Smad2.	hsa_circ_0001722	CircCDK14	hsa_circ_CDK14	CDK14	Osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR; ISH; RNA-seq	"CircCDK14 is down-regulated in osteoarthritic weight-bearing cartilage and exerts protective effects by maintaining ECM anabolism, promoting proliferation, and inhibiting apoptosis in chondrocytes. Mechanistically, it functions as a cytoplasmic ceRNA that sponges miR-125a-5p to support Smad2 expression and modulate TGF-beta/SMAD signaling; AAV-mediated CircCDK14 overexpression alleviates OA in an ACLT rabbit model."	0.8378
32802409	Cell death discovery	2020	Circular RNA cIARS regulates ferroptosis in HCC cells through interacting with RNA binding protein ALKBH5.	hsa_circ_0008367	cIARS	hsa_circ_IARS	IARS	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"In sorafenib-treated HCC cell lines, cIARS (hsa_circ_0008367, from IARS) is upregulated and promotes ferroptosis and drug cytotoxicity. Mechanistically, it binds the RBP ALKBH5 and counteracts ALKBH5-driven autophagy inhibition, thereby enhancing autophagic flux/ferritinophagy to support ferroptotic events."	0.7742
32804726	Chinese medical journal	2020	Up-regulation of circular RNA hsa_circ_01844 induces apoptosis and suppresses proliferation and migration of glioblastoma cells.		hsa_circ_01844 			glioblastoma	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR	"hsa_circ_01844 is down-regulated in glioblastoma tissues. Forced overexpression in U87 and U251 cells inhibits cell cycle progression, proliferation/colony formation, and migration, while promoting apoptosis. The paper proposes (bioinformatically) that it may interact with miRNA-616 and miRNA-671-5p, but this mechanism is not experimentally validated."	0.5751
32805720	Aging	2020	hsa_circRNA6448-14 promotes carcinogenesis in esophageal squamous cell carcinoma.		hsa_circRNA6448-14 	hsa_circ_TGFBI	TGFBI	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circRNA6448-14 is up-regulated in ESCC tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion) while inhibiting apoptosis. Mechanistically, it functions as a miRNA sponge by binding miR-455-3p, and higher expression is associated with worse DFS/OS and diagnostic value in ESCC."	0.7628
32805720	Aging	2020	hsa_circRNA6448-14 promotes carcinogenesis in esophageal squamous cell carcinoma.		hsa_circRNA15930-8 	hsa_circ_SH2D3C	SH2D3C	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	hsa_circRNA15930-8 is significantly down-regulated in ESCC tissues versus adjacent normal tissues and shows modest diagnostic value by ROC analysis (AUC 0.673). No mechanism or functional assays were reported for this circRNA in this study.	0.4679
32808350	Journal of clinical laboratory analysis	2020	Identification of plasma hsa_circ_0008673 expression as a potential biomarker and tumor regulator of breast cancer.	hsa_circ_0008673		hsa_circ_BRCA1	BRCA1	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0008673 is up-regulated in breast cancer patient plasma and breast cancer cell lines. High plasma levels have diagnostic value and are associated with worse OS/DSS. Functionally, hsa_circ_0008673 promotes proliferation and metastatic traits, as its knockdown induces G1 arrest and suppresses migration/invasion in MDA-MB-231 and MCF-7 cells."	0.7408
32808450	Journal of cellular and molecular medicine	2020	CircPSMC3 alleviates the symptoms of PCOS by sponging miR-296-3p and regulating PTEN expression.		circPSMC3 	hsa_circ_PSMC3	PSMC3	polycystic ovary syndrome 	MONDO:0008487	polycystic ovary syndrome	down-regulated	RT-qPCR	"circPSMC3 is down-regulated in ovarian granulosa cells from PCOS patients. Its overexpression alleviates PCOS-like phenotypes in a DHEA-induced mouse model and suppresses granulosa-like cell proliferation while promoting apoptosis. Mechanistically, circPSMC3 sponges miR-296-3p to increase PTEN expression (circPSMC3/miR-296-3p/PTEN ceRNA axis)."	0.7554
32808501	Journal of gynecologic oncology	2020	Circulating exosomal circFoxp1 confers cisplatin resistance in epithelial ovarian cancer cells.		circFoxp1	hsa_circ_FOXP1	Foxp1	epithelial ovarian cancer 	MONDO:0005140	ovarian carcinoma	up-regulated	RT-qPCR	"Circulating serum exosomal circFoxp1 is up-regulated in EOC, especially in cisplatin-resistant patients, and high levels predict poorer survival and recurrence. Functionally, circFoxp1 promotes proliferation and cisplatin resistance in vitro and in a xenograft model by sponging miR-22 and miR-150-3p, thereby increasing CEBPG and FMNL3 expression."	0.7853
32812415	Turkish journal of haematology : official journal of Turkish Society of Haematology	2020	Circulating Exosomal CircMYC Is Associated with Recurrence and Bortezomib Resistance in Patients with Multiple Myeloma.	hsa_circ_0085533	circMYC	hsa_circ_MYC	MYC	multiple myeloma 	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR	"Circulating serum exosomal circMYC (hsa_circ_0085533, host gene MYC) is up-regulated in multiple myeloma and is higher in bortezomib-resistant/relapsed settings. High exosomal circMYC predicts higher relapse and mortality and independently indicates poor OS/PFS, supporting its use as a diagnostic/prognostic biomarker; mechanistic functions were not tested."	0.5727
32814879	Cell death and differentiation	2021	CircRNA-vgll3 promotes osteogenic differentiation of adipose-derived mesenchymal stem cells via modulating miRNA-dependent integrin alpha5 expression.		circRNA-vgll3 	rno_circ_vgll3	vgll3	critical-sized bone defects 	MONDO:0005381	bone disorder	up-regulated	RT-qPCR; RNA-seq	"circRNA-vgll3 is upregulated during BMP2-induced osteogenic differentiation of rat ADSCs and promotes osteogenesis. Mechanistically, it acts as a cytoplasmic miRNA sponge for miR-326-5p to increase Itga5 protein expression, enhancing bone regeneration in a rat critical-sized calvarial defect model."	0.8547
32817745	Cancer cell international	2020	"CircHIPK3/miR-876-5p/PIK3R1 axis regulates regulation proliferation, migration, invasion, and glutaminolysis in gastric cancer cells."	hsa_circ_0000284	circHIPK3	hsa_circ_HIPK3	HIPK3	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"CircHIPK3 is up-regulated in gastric cancer tissues and cell lines and promotes proliferation, migration, invasion, glutaminolysis, and xenograft tumor growth. Mechanistically, it acts as a ceRNA to sponge miR-876-5p and thereby increases PIK3R1 expression."	0.7164
32819442	Biological research	2020	Hypoxia inducible factor-1 (HIF-1alpha) reduced inflammation in spinal cord injury via miR-380-3p/ NLRP3 by Circ 0001723.		Circ 0001723			spinal cord injury 	MONDO:0043797	spinal cord injury	down-regulated	RT-qPCR; Microarray	"Circ 0001723 is down-regulated in SCI rat spinal cord. Functionally, manipulating Circ 0001723 alters inflammatory cytokine production, and mechanistically it acts through a miR-380-3p_HIF-1alpha/NLRP3/caspase-1 cascade with involvement of autophagy and NF-kappaB signaling in SCI inflammation."	0.5979
32821115	OncoTargets and therapy	2020	CircHIPK3 Promotes Clear Cell Renal Cell Carcinoma (ccRCC) Cells Proliferation and Metastasis via Altering of miR-508-3p/CXCL13 Signal.		circHIPK3	hsa_circ_HIPK3	HIPK3	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR; ISH	"circHIPK3 is upregulated in ccRCC and promotes proliferation and metastatic behaviors. Mechanistically, it acts as a cytoplasmic ceRNA that sponges miR-508-3p, thereby relieving repression of CXCL13 and enhancing CXCL13 expression. High circHIPK3 is associated with worse clinicopathological features and poorer overall survival."	0.8659
32821119	OncoTargets and therapy	2020	Knockdown of circ_0000512 Inhibits Cell Proliferation and Promotes Apoptosis in Colorectal Cancer by Regulating miR-296-5p/RUNX1 Axis.	hsa_circ_0000512	circ_0000512 			colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circ_0000512 is up-regulated in colorectal cancer and acts as an oncogenic circRNA. Its knockdown inhibits proliferation, induces G0/G1 arrest and promotes apoptosis by functioning as a miR-296-5p sponge to increase RUNX1 expression, and it suppresses xenograft tumor growth in vivo."	0.8399
32821160	Cancer management and research	2020	circ_0136666 Facilitates the Progression of Colorectal Cancer via miR-383/CREB1 Axis.	hsa_circ_0136666	circ_0136666	hsa_circ_PRKDC	PRKDC	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0136666 is up-regulated in colorectal cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes CRC cell proliferation and glycolysis and inhibits apoptosis by sponging miR-383 to up-regulate CREB1, leading to increased HK2 and LDHA and enhanced tumor growth in xenografts."	0.6521
32821699	Journal of lipid and atherosclerosis	2019	Analysis of Circular RNAs in the Coronary Arteries of Patients with Kawasaki Disease.		circHIPK3	hsa_circ_HIPK3		Kawasaki disease	MONDO:0012727	Kawasaki disease	down-regulated	RNA-seq	"circHIPK3 is significantly down-regulated in coronary artery tissue from untreated Kawasaki disease patients and returns to normal levels after treatment, suggesting potential utility as a disease-status biomarker. This study does not experimentally validate a specific mechanistic axis for circHIPK3 in Kawasaki disease."	0.1768
32821699	Journal of lipid and atherosclerosis	2019	Analysis of Circular RNAs in the Coronary Arteries of Patients with Kawasaki Disease.		circZNF124	hsa_circ_ZNF124		Kawasaki disease	MONDO:0012727	Kawasaki disease	down-regulated	RNA-seq	"circZNF124 is significantly down-regulated in coronary artery tissue from untreated Kawasaki disease and returns to control-like levels after treatment, supporting its potential as a biomarker. Bioinformatic prediction suggests circZNF124 may suppress miR-181b-5p via multiple binding sites."	0.1768
32821699	Journal of lipid and atherosclerosis	2019	Analysis of Circular RNAs in the Coronary Arteries of Patients with Kawasaki Disease.		circWHAMMP1	hsa_circ_WHAMMP1		Kawasaki disease	MONDO:0012727	Kawasaki disease	down-regulated	RNA-seq	"circWHAMMP1 is significantly down-regulated in coronary artery tissue from untreated Kawasaki disease and normalizes after treatment, indicating potential biomarker value. TargetScan-based prediction suggests a regulatory relationship between circWHAMMP1 and miR-663b consistent with a miRNA-sponge hypothesis, without experimental validation."	0.1768
32821699	Journal of lipid and atherosclerosis	2019	Analysis of Circular RNAs in the Coronary Arteries of Patients with Kawasaki Disease.		circSLAIN2	hsa_circ_SLAIN2		Kawasaki disease	MONDO:0012727	Kawasaki disease	down-regulated	RNA-seq	"circSLAIN2 is down-regulated in coronary artery tissue from untreated Kawasaki disease and returns to normal after treatment, suggesting potential biomarker utility. The study does not provide a specific mechanistic interaction for circSLAIN2."	0.1768
32821699	Journal of lipid and atherosclerosis	2019	Analysis of Circular RNAs in the Coronary Arteries of Patients with Kawasaki Disease.		circATM	hsa_circ_ATM		Kawasaki disease	MONDO:0012727	Kawasaki disease	down-regulated	RNA-seq	"circATM is down-regulated in coronary artery tissue from untreated Kawasaki disease and returns to normal levels after treatment, supporting its candidacy as a biomarker reflecting disease status. No specific downstream mechanism is experimentally established in this study."	0.1768
32823854	Biomolecules	2020	Association between Circular RNA CDR1as and Post-Infarction Cardiac Function in Pig Ischemic Heart Failure: Influence of the Anti-Fibrotic Natural Compounds Bufalin and Lycorine.		CDR1as 	ssc_circ_CDR1AS		ischemic heart failure 	MONDO:0024644	myocardial ischemia	up-regulated	RT-qPCR	"In a porcine reperfused AMI model leading to ischemic HF, CDR1as is detectable and becomes upregulated in infarct tissue, particularly with bufalin treatment. Higher CDR1as levels correlate with better LV/RV function and smaller infarct size, and it is discussed as acting through miRNA sponging (notably miR-7) with links to miR-671/miR-7 dynamics."	0.5202
32826876	Cell death & disease	2020	The circEPSTI1/mir-942-5p/LTBP2 axis regulates the progression of OSCC in the background of OSF via EMT and the PI3K/Akt/mTOR pathway.	hsa_circ_0000479	circEPSTI1	hsa_circ_EPSTI1	EPSTI1	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circEPSTI1 is sequentially up-regulated from NBM to OSF to OSCC and promotes OSCC cell proliferation, migration and invasion. Mechanistically, it functions as a ceRNA to sponge miR-942-5p, thereby increasing LTBP2 expression, accelerating EMT and enhancing PI3K/Akt/mTOR pathway activation; high circEPSTI1 predicts poor OS and PFS."	0.8961
32827242	Journal of cellular and molecular medicine	2020	Circular RNA VMA21 ameliorates sepsis-associated acute kidney injury by regulating miR-9-3p/SMG1/inflammation axis and oxidative stress.	hsa_circ_0091702	circVMA21	hsa_circ_VMA21	VMA21	sepsis-associated acute kidney injury 	MONDO:0005229	bacterial infectious disease with sepsis	down-regulated	RT-qPCR	"circVMA21 is down-regulated in sepsis-associated AKI and its overexpression alleviates kidney injury by reducing apoptosis, inflammation, and oxidative stress. Mechanistically, circVMA21 sponges miR-9-3p to derepress SMG1, forming a circVMA21/miR-9-3p/SMG1 axis."	0.6276
32831141	Stem cell research & therapy	2020	Circular RNA SIPA1L1 promotes osteogenesis via regulating the miR-617/Smad3 axis in dental pulp stem cells.		circSIPA1L1	hsa_circ_SIPA1L1	SIPA1L1	bone regeneration 	MONDO:0005381	bone disorder	up-regulated	RT-qPCR	"circSIPA1L1 is upregulated during osteogenic differentiation of dental pulp stem cells and promotes osteogenesis. Mechanistically, it acts as a miRNA sponge for miR-617 in the cytoplasm, relieving repression on Smad3 (including phosphorylated Smad3) and enhancing osteogenic marker expression and mineralization, supported by in vitro assays and a nude mouse subcutaneous implantation model."	0.7263
32831647	Cancer cell international	2020	Circular RNA circ_0020123 promotes non-small cell lung cancer progression by sponging miR-590-5p to regulate THBS2.	hsa_circ_0020123	circ_0020123			non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0020123 is upregulated in NSCLC tissues/cells and functions as an oncogenic circRNA. It sponges miR-590-5p to upregulate THBS2, thereby promoting proliferation and migration and inhibiting apoptosis, and its knockdown suppresses xenograft tumor growth."	0.6825
32831649	Cancer cell international	2020	FOXA1-induced circOSBPL10 potentiates cervical cancer cell proliferation and migration through miR-1179/UBE2Q1 axis.	hsa_circ_0064669	circOSBPL10	hsa_circ_OSBPL10	OSBPL10	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circOSBPL10 (hsa_circ_0064669), derived from OSBPL10, is up-regulated in cervical cancer cell lines and mainly localized in the cytoplasm. It promotes proliferation and migration (and suppresses apoptosis) by acting as a ceRNA that sponges miR-1179, thereby increasing UBE2Q1 expression; FOXA1 transcriptionally activates OSBPL10 to induce circOSBPL10."	0.808
32831653	Cancer cell international	2020	CircZFR functions as a sponge of miR-578 to promote breast cancer progression by regulating HIF1A expression.	hsa_circ_0072088	circZFR	hsa_circ_ZFR		breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circZFR is up-regulated in breast cancer and its high expression correlates with worse overall survival. Functionally, circZFR promotes malignant phenotypes (proliferation/colony formation, migration/invasion, glycolysis) and suppresses apoptosis. Mechanistically, circZFR sponges miR-578 to de-repress HIF1A, forming a circZFR/miR-578/HIF1A regulatory axis."	0.7552
32838810	Molecular cancer	2020	CircRNA inhibits DNA damage repair by interacting with host gene.		circSMARCA5	hsa_circ_SMARCA5	SMARCA5	breast cancer	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Northern Blot; ISH; RNA-seq	"In breast cancer, circSMARCA5 is down-regulated in tumors and cell lines. circSMARCA5 binds the SMARCA5 genomic locus to form an R-loop, causing transcriptional termination around exon 15, reducing SMARCA5 and generating nonfunctional truncated deltaSMARCA5, thereby inhibiting DNA damage repair and increasing cisplatin/bleomycin sensitivity in vitro and in MCF-7 xenografts."	0.8576
32844469	Journal of clinical laboratory analysis	2020	"Analysis of circular RNA expression profiles of lung cancer in Xuanwei, China."	hsa_circ_0005927	hsa_circRNA_104600			lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; Microarray	hsa_circ_0005927 is significantly up-regulated in LCXW tumor tissues and is associated with larger tumor size. The study suggests it may act via a predicted miRNA-sponge mechanism and could serve as a potential biomarker for LCXW.	0.5541
32844469	Journal of clinical laboratory analysis	2020	"Analysis of circular RNA expression profiles of lung cancer in Xuanwei, China."	hsa_circ_0001936	hsa_circRNA_105013			lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0001936 is significantly down-regulated in LCXW by RT-qPCR (opposite to microarray). Its dysregulation is associated with tumor size, and it is proposed as a potential biomarker; predicted miRNA interactions suggest a possible miRNA-sponge role."	0.5541
32844469	Journal of clinical laboratory analysis	2020	"Analysis of circular RNA expression profiles of lung cancer in Xuanwei, China."		hsa_circ_406010	hsa_circ_HECW2	HECW2	lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_406010 is significantly down-regulated in LCXW tumor tissues and lower expression is associated with poor prognosis. It is an intronic circRNA linked to host gene HECW2 (no expression correlation observed) and is predicted to sponge several miRNAs, supporting its potential as a prognostic biomarker."	0.63
32846020	Journal of cellular and molecular medicine	2020	CircC3P1 attenuated pro-inflammatory cytokine production and cell apoptosis in acute lung injury induced by sepsis through modulating miR-21.		circC3P1	mmu_circ_C3P1	C3P1	acute lung injury 	MONDO:0015796	acute lung injury	down-regulated	RT-qPCR	"In sepsis-induced acute lung injury models (CLP mice and LPS-treated MPVECs), circC3P1 is down-regulated and its overexpression protects against lung injury by suppressing inflammation and apoptosis. Mechanistically, circC3P1 negatively regulates miR-21 and reduces p-AKT/AKT signaling and pro-inflammatory cytokine production."	0.4236
32847606	Journal of experimental & clinical cancer research : CR	2020	CircRNA hsa_circ_0002577 accelerates endometrial cancer progression through activating IGF1R/PI3K/Akt pathway.	hsa_circ_0002577	hsa_circ_002577	hsa_circ_WDR26	WDR26	Endometrial cancer 	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR; ISH	"hsa_circ_0002577 is upregulated in endometrial cancer and functions as an oncogenic circRNA. It sponges miR-625-5p to upregulate IGF1R and activate the PI3K/Akt pathway, promoting proliferation, migration/invasion, angiogenesis-related tube formation, and tumor growth/metastasis; high expression is associated with poorer overall survival."	0.8428
32848418	OncoTargets and therapy	2020	The Potential Tumor Promotional Role of circVAPA in Retinoblastoma via Regulating miR-615-3p and SMARCE1.		circVAPA	hsa_circ_VAPA		Retinoblastoma 	MONDO:0008380	retinoblastoma	up-regulated	RT-qPCR	"circVAPA is upregulated in retinoblastoma tissues and cell lines and is associated with poorer prognosis. Functionally, circVAPA promotes proliferation and metastatic phenotypes and inhibits apoptosis, at least partly by sponging miR-615-3p to increase SMARCE1 expression."	0.7412
32848465	Cancer management and research	2020	"Circular RNA MAT2B Induces Colorectal Cancer Proliferation via Sponging miR-610, Resulting in an Increased E2F1 Expression."		circMAT2B 	hsa_circ_MAT2B	MAT2B	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circMAT2B is upregulated in colorectal cancer tissues and cell lines and promotes CRC cell proliferation. Mechanistically, circMAT2B sponges miR-610, relieving repression of the miR-610 target E2F1 and thereby increasing E2F1 expression."	0.7032
32848466	Cancer management and research	2020	Circular RNA circNHSL1 Contributes to Gastric Cancer Progression Through the miR-149-5p/YWHAZ Axis.	hsa_circ_0006835	circNHSL1	hsa_circ_NHSL1	NHSL1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circNHSL1 is up-regulated in gastric cancer tissues, cells, and serum/cell-derived exosomes. It promotes GC migration, invasion, glutaminolysis and in vivo tumor growth by acting as a ceRNA that sponges miR-149-5p to increase YWHAZ expression."	0.7759
32848851	Frontiers in physiology	2020	circAFF1 Aggravates Vascular Endothelial Cell Dysfunction Mediated by miR-516b/SAV1/YAP1 Axis.		circAFF1 	hsa_circ_AFF1	AFF1	subarachnoid hemorrhage 	MONDO:0005099	subarachnoid hemorrhage	up-regulated	RT-qPCR	"circAFF1 is up-regulated in hypoxia-treated endothelial cells and in serum of SAH patients. It localizes mainly to the cytoplasm and functions as a ceRNA sponge for miR-516b, increasing SAV1 and YAP1 phosphorylation (Hippo/YAP-related signaling), thereby inhibiting endothelial proliferation/tube formation/migration and promoting apoptosis. The authors suggest circAFF1 may have early diagnostic value for hypoxia-related vascular diseases."	0.7893
32850310	Frontiers in oncology	2020	Circular RNA 103862 Promotes Proliferation and Invasion of Laryngeal Squamous Cell Carcinoma Cells Through the miR-493-5p/GOLM1 Axis.	hsa_circ_0072758	circRNA_103862			laryngeal squamous cell carcinoma 	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR; ISH	"circRNA_103862 is up-regulated in LSCC tissues/cell lines and mainly localizes to the cytoplasm. It promotes LSCC proliferation, migration, invasion, and xenograft growth by acting as a ceRNA that sponges miR-493-5p to increase GOLM1 expression. High circRNA_103862 is associated with lymph-node metastasis and poor overall survival, and shows diagnostic potential by ROC analysis."	0.7718
32850833	Frontiers in cell and developmental biology	2020	Circular RNA cMTO1 Promotes PTEN Expression Through Sponging miR-181b-5p in Liver Fibrosis.	hsa_circ_0007874	cMTO1 	hsa_circ_MTO1	MTO1	liver fibrosis 	MONDO:0100430	fibrotic liver disease	down-regulated	RT-qPCR	"cMTO1 is down-regulated in cirrhotic/fibrotic liver and activated HSCs, and its restoration suppresses HSC proliferation and activation markers. Mechanistically, cMTO1 sponges miR-181b-5p in the cytoplasm to relieve repression of PTEN, thereby inhibiting fibrotic activation (via the PTEN-related PI3K/Akt context)."	0.8389
32850833	Frontiers in cell and developmental biology	2020	Circular RNA cMTO1 Promotes PTEN Expression Through Sponging miR-181b-5p in Liver Fibrosis.	mmu_circ_0015911		mmu_circ_MTO1	MTO1	liver fibrosis	MONDO:0100430	fibrotic liver disease	down-regulated	RT-qPCR	mmu_circ_0015911 (a mouse MTO1-derived circRNA splice) is reduced in CCl4-induced fibrotic mouse livers; it was selected for subsequent experiments due to its lower expression compared with other MTO1 splice circRNAs.	0.2586
32850833	Frontiers in cell and developmental biology	2020	Circular RNA cMTO1 Promotes PTEN Expression Through Sponging miR-181b-5p in Liver Fibrosis.	mmu_circ_0015912		mmu_circ_MTO1	MTO1	liver fibrosis	MONDO:0100430	fibrotic liver disease	down-regulated	RT-qPCR	mmu_circ_0015912 (a mouse MTO1-derived circRNA splice) shows reduced expression in CCl4-induced fibrotic mouse livers; no mechanism or functional experiments were reported for this specific circRNA.	0.2586
32850833	Frontiers in cell and developmental biology	2020	Circular RNA cMTO1 Promotes PTEN Expression Through Sponging miR-181b-5p in Liver Fibrosis.	mmu_circ_0015913		mmu_circ_MTO1	MTO1	liver fibrosis	MONDO:0100430	fibrotic liver disease	down-regulated	RT-qPCR	mmu_circ_0015913 (a mouse MTO1-derived circRNA splice) is reduced in CCl4-induced fibrotic mouse livers; no downstream mechanism or functional validation was reported for this specific circRNA.	0.2586
32851074	BioMed research international	2020	Circular RNA circCCDC66 Contributes to Malignant Phenotype of Osteosarcoma by Sponging miR-338-3p to Upregulate the Expression of PTP1B.		circCCDC66	hsa_circ_CCDC66	CCDC66	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circCCDC66 is up-regulated in osteosarcoma tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion). Mechanistically, it acts mainly in the cytoplasm as a ceRNA sponging miR-338-3p to upregulate PTP1B."	0.7291
32852391	Chinese medical journal	2020	Expression profile of circular RNAs in epicardial adipose tissue in heart failure.	hsa_circ_0005565				heart failure 	MONDO:0005252	heart failure	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005565 is significantly up-regulated in epicardial adipose tissue from CAD patients with heart failure compared with non-HF controls, and is proposed as a potential biomarker for HF."	0.3588
32855967	BioMed research international	2020	Circular RNA circ_0026359 Enhances Cisplatin Resistance in Gastric Cancer via Targeting miR-1200/POLD4 Pathway.	hsa_circ_0026359	circ_0026359 			gastric cancer	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_0026359 is up-regulated in gastric cancer, especially in CDDP-resistant tissues/cells, and high expression predicts worse OS/RFS. It mainly localizes to the cytoplasm and promotes cisplatin resistance by sponging miR-1200, thereby increasing POLD4 expression; miR-1200/POLD4 mediates this effect."	0.7967
32856037	Bioscience reports	2020	Profiling and bioinformatics analyses reveal differential circular RNA expression in NK/T-cell lymphoma-associated hemophagocytic syndrome.	hsa_circ_0073586	chr5:112090570-112137080+			NK/T-cell lymphoma-associated hemophagocytic syndrome	MONDO:0015540	hemophagocytic syndrome	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0073586 is significantly up-regulated in NK/T-LAHS patient serum (NGS and RT-qPCR consistent). It was selected based on predicted NK/T-LAHS-related miRNA binding sites, suggesting a potential ceRNA/miRNA-sponge role and potential diagnostic biomarker value."	0.4032
32856037	Bioscience reports	2020	Profiling and bioinformatics analyses reveal differential circular RNA expression in NK/T-cell lymphoma-associated hemophagocytic syndrome.	hsa_circ_0114150	chr1:77620134-77635080_			NK/T-cell lymphoma-associated hemophagocytic syndrome	MONDO:0015540	hemophagocytic syndrome	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0114150 is significantly up-regulated in NK/T-LAHS patient serum and was validated by RT-qPCR consistent with RNA-seq. It was selected for predicted NK/T-LAHS-related miRNA binding sites, supporting a potential miRNA-sponge role and diagnostic biomarker potential."	0.4032
32856037	Bioscience reports	2020	Profiling and bioinformatics analyses reveal differential circular RNA expression in NK/T-cell lymphoma-associated hemophagocytic syndrome.	hsa_circ_0027353	chr12:62715245-62749256+			NK/T-cell lymphoma-associated hemophagocytic syndrome	MONDO:0015540	hemophagocytic syndrome	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0027353 is up-regulated in NK/T-LAHS serum and validated by RT-qPCR consistent with RNA-seq. It was selected due to predicted NK/T-LAHS-related miRNA binding sites, supporting a potential miRNA-sponge/ceRNA role and diagnostic biomarker potential."	0.4032
32856037	Bioscience reports	2020	Profiling and bioinformatics analyses reveal differential circular RNA expression in NK/T-cell lymphoma-associated hemophagocytic syndrome.	hsa_circ_0115056	chr20:34304662-34320057_			NK/T-cell lymphoma-associated hemophagocytic syndrome	MONDO:0015540	hemophagocytic syndrome	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0115056 is up-regulated in NK/T-LAHS serum and validated by RT-qPCR consistent with RNA-seq. It was selected for predicted NK/T-LAHS-related miRNA binding sites, supporting a potential miRNA-sponge/ceRNA role and diagnostic biomarker potential."	0.4032
32856037	Bioscience reports	2020	Profiling and bioinformatics analyses reveal differential circular RNA expression in NK/T-cell lymphoma-associated hemophagocytic syndrome.	hsa_circ_0131996	chr6:56989532-57025950+ 			NK/T-cell lymphoma-associated hemophagocytic syndrome	MONDO:0015540	hemophagocytic syndrome	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0131996 is significantly up-regulated in NK/T-LAHS serum and validated by RT-qPCR consistent with RNA-seq. The study predicts it functions as a miRNA sponge via multiple NK/T-LAHS-related miRNA binding sites, supporting potential diagnostic biomarker value."	0.4032
32857753	Medical science monitor : international medical journal of experimental and clinical research	2020	Circ_cse1l Inhibits Colorectal Cancer Proliferation by Binding to eIF4A3.	hsa_circ_0060745	circ_cse1l 	hsa_circ_CSE1L	CSE1L	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"circ_cse1l (hsa_circ_0060745), a CSE1L-derived circRNA, is downregulated in colorectal cancer tissues/serum and CRC cell lines. Functionally, circ_cse1l overexpression suppresses CRC cell proliferation, migration and invasion, and mechanistically it binds eIF4A3 to reduce PCNA mRNA/protein expression."	0.6278
32862195	Cancer gene therapy	2021	Hsa_circRNA_102002 facilitates metastasis of papillary thyroid cancer through regulating miR-488-3p/HAS2 axis.		hsa_circRNA_102002 	hsa_circ_USP22	USP22	papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"Hsa_circRNA_102002 (circ_102002; hsa_circ_102002) is up-regulated in papillary thyroid cancer and promotes EMT, migration/invasion and in vivo lung metastasis. Mechanistically, it sponges miR-488-3p to relieve repression of HAS2, leading to increased FAK/Akt phosphorylation and EMT marker changes; high expression is associated with poorer overall survival and metastasis."	0.8456
32862732	RNA biology	2021	Circular ANRIL isoforms switch from repressors to activators of p15/CDKN2B expression during RAF1 oncogene-induced senescence.		circANRIL e7-e5	hsa_circ_ANRIL	ANRIL	oncogene-induced senescence 	MONDO:0004992	cancer	up-regulated	RT-qPCR	"circANRIL e7-e5 is induced in RAF1-driven oncogene-induced senescence and, together with circANRIL e16-e5, is required for full transcriptional induction of INK4 locus genes (p15, p16, p14ARF) in senescent cells, while repressing p15 in proliferative fibroblasts."	0.6715
32862732	RNA biology	2021	Circular ANRIL isoforms switch from repressors to activators of p15/CDKN2B expression during RAF1 oncogene-induced senescence.		circANRIL e16-e5	hsa_circ_ANRIL	ANRIL	oncogene-induced senescence 	MONDO:0004992	cancer	up-regulated	RT-qPCR	"circANRIL e16-e5 is up-regulated in RAF1 oncogene-induced senescence and helps drive transcriptional activation of INK4 genes. Mechanistically, RNAs containing the e16-e5 back-spliced junction bind PRC2 components (EZH2/SUZ12) and influence EZH2 recruitment and H3K27 acetylation/methylation at the INK4 locus."	0.7549
32863763	Cancer cell international	2020	Circular RNA circ_0000517 regulates hepatocellular carcinoma development via miR-326/IGF1R axis.	hsa_circ_0000517	circ_0000517			hepatocellular carcinoma	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0000517 is up-regulated in hepatocellular carcinoma and promotes malignant phenotypes (proliferation/viability, migration, invasion and glycolysis). Mechanistically, it acts as a ceRNA that sponges miR-326 to increase IGF1R expression, and circ_0000517 knockdown suppresses tumor growth in a Huh7 xenograft model."	0.7177
32863766	Cancer cell international	2020	"Circ_0000140 restrains the proliferation, metastasis and glycolysis metabolism of oral squamous cell carcinoma through upregulating CDC73 via sponging miR-182-5p."	hsa_circ_0000140	circ_0000140	hsa_circ_KIAA0907	KIAA0907	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR	"circ_0000140 is down-regulated in OSCC tissues and cell lines and is mainly localized in the cytoplasm. Its overexpression suppresses OSCC cell proliferation, migration/invasion and glycolysis, and inhibits tumor growth in a xenograft model, at least partly via the circ_0000140/miR-182-5p/CDC73 axis."	0.6996
32863771	Cancer cell international	2020	CircRNA hsa_circRNA_0001776 inhibits proliferation and promotes apoptosis in endometrial cancer via downregulating LRIG2 by sponging miR-182.	hsa_circ_0001776	hsa_circRNA_0001776 			endometrial cancer 	MONDO:0011962	endometrial cancer	down-regulated	RT-qPCR	"circ_0001776 is down-regulated in endometrial cancer and mainly localized in the cytoplasm. It suppresses EC cell proliferation and glycolysis while promoting apoptosis by acting as a ceRNA that sponges miR-182 to upregulate LRIG2, and it inhibits xenograft tumor growth. Low circ_0001776 expression is associated with worse patient survival and it shows diagnostic potential by ROC analysis."	0.8066
32867570	Bioengineered	2020	Circular RNA circ-LRP6 facilitates Myc-driven tumorigenesis in esophageal squamous cell cancer.		circ-LRP6	hsa_circ_LRP6	LRP6	esophageal squamous cell cancer 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"circ-LRP6 is up-regulated in ESCC tissues and promotes ESCC proliferation/invasion and xenograft tumor growth. Mechanistically, it localizes mainly in the cytoplasm and functions as a ceRNA by sponging miR-182, thereby relieving repression of Myc and increasing Myc expression; clinically, higher circ-LRP6 associates with advanced features and poorer survival."	0.8555
32877369	Aging	2020	CircRNA circ_0072995 promotes the progression of epithelial ovarian cancer by modulating miR-147a/CDK6 axis.	hsa_circ_0072995	circ_0072995 	hsa_circ_ARHGEF28	ARHGEF28	epithelial ovarian cancer 	MONDO:0005140	ovarian carcinoma	up-regulated	RT-qPCR	"circ_0072995 is up-regulated in epithelial ovarian cancer tissues/cell lines and mainly localizes to the cytoplasm. It promotes EOC proliferation, migration/invasion and tumor growth while suppressing apoptosis, by sponging miR-147a to derepress CDK6 (circ_0072995/miR-147a/CDK6 axis). Its expression correlates with pathological grade in EOC patients."	0.6837
32884301	OncoTargets and therapy	2020	Circular RNA circEXOC6B Inhibits the Progression of Ovarian Cancer by Sponging miR-421 and Regulating RUS1 Expression.		circEXOC6B	hsa_circ_EXOC6B	EXOC6B	ovarian cancer 	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR	"circEXOC6B is down-regulated in ovarian cancer cell lines (SKOV3 and OVCAR3 vs IOSE80) and acts as a tumor suppressor. It inhibits proliferation and invasion and promotes apoptosis by sponging miR-421, thereby relieving miR-421-mediated repression of RSU1."	0.5997
32884344	Cancer management and research	2020	"Blocking circ_0013912 Suppressed Cell Growth, Migration and Invasion of Pancreatic Ductal Adenocarcinoma Cells in vitro and in vivo Partially Through Sponging miR-7-5p."	hsa_circ_0013912	circ_0013912 	hsa_circ_POLR3C	POLR3C	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circ_0013912 is up-regulated in PDAC tissues and cell lines and correlates with advanced TNM stage and lymph node metastasis. Its knockdown suppresses PDAC cell proliferation/colony formation, migration and invasion, promotes apoptosis, and inhibits tumor growth in a cell line-derived xenograft model, partly by sponging miR-7-5p."	0.7384
32884349	Cancer management and research	2020	Circ-SAR1A Promotes Renal Cell Carcinoma Progression Through miR-382/YBX1 Axis.		circ-SAR1A 	hsa_circ_SAR1A	SAR1A	renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR; Microarray	"circ-SAR1A is up-regulated in RCC/ccRCC tissues and cell lines and is associated with advanced Fuhrman grade and lymph-node metastasis. Functionally, circ-SAR1A promotes RCC cell proliferation and invasion in vitro by acting as a cytoplasmic miRNA sponge for miR-382, thereby increasing YBX1 expression (circ-SAR1A/miR-382/YBX1 ceRNA axis)."	0.692
32884351	Cancer management and research	2020	Circ_0015756 Aggravates Hepatocellular Carcinoma Development by Regulating FGFR1 via Sponging miR-610.	hsa_circ_0015756	circ_0015756	hsa_circ_CFH	CFH	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0015756 is up-regulated in HCC tissues/serum/cells and promotes malignant phenotypes and xenograft tumor growth. Mechanistically, it sponges miR-610 to de-repress FGFR1, forming a circ_0015756/miR-610/FGFR1 ceRNA axis."	0.7296
32884449	Cancer cell international	2020	Identification of circular RNA hsa_circ_0044556 and its effect on the progression of colorectal cancer.	hsa_circ_0044556		hsa_circ_COL1A1	COL1A1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0044556 is up-regulated in colorectal cancer tissues and is associated with advanced tumor stage and lymph node metastasis. Functionally, its knockdown suppresses CRC cell proliferation, migration, and invasion, suggesting an oncogenic role. Mechanistically, it was proposed to act as a miRNA sponge within a circRNA_miRNA_mRNA network, with hsa-mir-214-3p highlighted as inversely affected upon circRNA silencing."	0.7932
32889742	Journal of clinical laboratory analysis	2020	Association between circular RNA expression content and severity of coronary atherosclerosis in human coronary artery.	hsa_circ_0016868				coronary atherosclerosis 	MONDO:0021661	coronary atherosclerosis	dysregulated	RT-qPCR; RNA-seq	hsa_circ_0016868 is differentially expressed across coronary artery segments with different atherosclerosis severity and was validated by RT-qPCR and its back-splice junction confirmed by Sanger sequencing. The study suggests it may be involved in the pathological process of coronary atherosclerosis and could be a potential diagnostic/therapeutic target for CAD.	0.5541
32889742	Journal of clinical laboratory analysis	2020	Association between circular RNA expression content and severity of coronary atherosclerosis in human coronary artery.	hsa_circ_0001364				coronary atherosclerosis 	MONDO:0021661	coronary atherosclerosis	dysregulated	RT-qPCR; RNA-seq	hsa_circ_0001364 shows differential expression among coronary artery segments with varying atherosclerosis severity and was validated by RT-qPCR with back-splice junction confirmed by Sanger sequencing. The study suggests it may be involved in coronary atherosclerosis and could represent a potential diagnostic/therapeutic target for CAD.	0.5541
32889742	Journal of clinical laboratory analysis	2020	Association between circular RNA expression content and severity of coronary atherosclerosis in human coronary artery.	hsa_circ_0006731				coronary atherosclerosis 	MONDO:0021661	coronary atherosclerosis	dysregulated	RT-qPCR; RNA-seq	hsa_circ_0006731 is differentially expressed among coronary artery segments with different atherosclerosis severity and was validated by RT-qPCR with its circular junction verified by Sanger sequencing. The study suggests it may contribute to coronary atherosclerosis and could be a potential diagnostic/therapeutic target for CAD.	0.5541
32892696	Bioengineered	2020	Circular RNA hsa_circ_0000034 promotes the progression of retinoblastoma via sponging microRNA-361-3p.	hsa_circ_0000034				retinoblastoma	MONDO:0008380	retinoblastoma	up-regulated	RT-qPCR	"hsa_circ_0000034 is up-regulated in retinoblastoma tissues and cell lines and is associated with advanced IIRC stage and optic nerve invasion. Functionally, it promotes retinoblastoma cell proliferation, migration, and invasion in vitro. Mechanistically, it mainly acts as a ceRNA by sponging miR-361-3p (supported by luciferase and AGO2-RIP), and miR-361-3p inhibition rescues the effects of hsa_circ_0000034 knockdown."	0.7295
32894144	Molecular cancer	2020	Circular RNA CDR1as disrupts the p53/MDM2 complex to inhibit Gliomagenesis.		CDR1as	hsa_circ_CDR1		glioma 	MONDO:0021042	glioma	down-regulated	RT-qPCR; ISH; RNA-seq	"CDR1as is down-regulated in glioma/GBM and acts as a tumor suppressor. It binds p53 (via the DBD), disrupts p53/MDM2 complex formation, reduces p53 ubiquitination, stabilizes p53 protein and enhances p53 pathway activity, leading to reduced glioma cell growth and increased cell-cycle arrest/apoptosis, including under DNA damage."	0.8424
32894165	Journal of experimental & clinical cancer research : CR	2020	The U2AF2 /circRNA ARF1/miR-342-3p/ISL2 feedback loop regulates angiogenesis in glioma stem cells.	hsa_circ_0016767		hsa_circ_ARF1	ARF1	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR	"cARF1 (hsa_circ_0016767), derived from ARF1, is up-regulated in glioma tissues and correlates with poor survival. It promotes glioma-associated angiogenesis and malignant phenotypes by sponging miR-342_3p to increase ISL2, thereby enhancing VEGFA output and downstream ERK signaling, and is reinforced by U2AF2-mediated stabilization in a feedback loop."	0.8593
32896032	Cancer science	2020	Circulating circERBB2 as a potential prognostic biomarker for gastric cancer: An investigative study.		circERBB2 	hsa_circ_ERBB2	ERBB2	gastric cancer 	MONDO:0001056	gastric cancer	unknown	RT-qPCR; Microarray	"This study identifies circulating circERBB2 (derived from ERBB2) as a plasma biomarker in gastric cancer. Detectable/high preoperative plasma circERBB2 is associated with lymph node metastasis and predicts worse relapse-free and overall survival. Plasma circERBB2 levels decrease after surgery and rise at recurrence, supporting its use for postoperative monitoring."	0.6605
32896063	Molecular oncology	2020	CircFNDC3B sequestrates miR-937-5p to derepress TIMP3 and inhibit colorectal cancer progression.		CircFNDC3B 	hsa_circ_FNDC3B	FNDC3B	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"circFNDC3B is down-regulated in colorectal cancer tissues/cell lines/exosomes and functions as a tumor suppressor. It sponges miR-937-5p to derepress TIMP3, thereby inhibiting EMT-associated proliferation, migration/invasion, angiogenesis (VEGFA/VEGFR), tumor growth and liver metastasis; circFNDC3B-enriched exosomes also convey anti-angiogenic effects."	0.8279
32901868	Molecular medicine reports	2020	"A novel identified circular RNA, circ_0000491, aggravates the extracellular matrix of diabetic nephropathy glomerular mesangial cells through suppressing miR_101b by targeting TGFbetaRI."	mmu_circ_0000491	circ_0000491 	mmu_circ_Homer1	Homer1	diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR; RNA-seq	"In diabetic nephropathy models (db/db mouse kidney and high-glucose MES13 cells), circ_0000491 is up-regulated and promotes ECM accumulation/fibrosis-associated protein expression and EMT. Mechanistically, it functions as a ceRNA by sponging miR-101b, thereby relieving repression of TGFbetaRI and enhancing TGF-beta/Smad-related fibrotic signaling."	0.7076
32901890	Oncology reports	2020	Circular RNA NOX4 promotes the development of colorectal cancer via the microRNA_485_5p/CKS1B axis.	hsa_circ_0023990	circNOX4 	hsa_circ_NOX4	NOX4	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circNOX4 is upregulated in colorectal cancer and is associated with poorer patient survival. Functionally, circNOX4 promotes CRC cell proliferation, migration, invasion, and glycolysis and enhances xenograft tumor growth by sponging miR-485-5p to increase CKS1B."	0.7992
32903845	Frontiers in oncology	2020	CircHIPK3 Promotes Metastasis of Gastric Cancer via miR-653-5p/miR-338-3p-NRP1 Axis Under a Long-Term Hypoxic Microenvironment.		circHIPK3	hsa_circ_HIPK3	HIPK3	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"In gastric cancer under long-term hypoxia, circHIPK3 is induced by HIF-2alpha and promotes migration/invasion. It functions as a ceRNA by sponging miR-653-5p and miR-338-3p to upregulate NRP1, thereby activating ERK and AKT signaling to enhance metastatic potential."	0.7399
32904464	PeerJ	2020	"CircHIPK3 regulates cardiac fibroblast proliferation, migration and phenotypic switching through the miR-152-3p/TGF-beta2 axis under hypoxia."	mmu_circ_0001052	circHIPK3	mmu_circ_Hipk3	Hipk3	cardiac fibrosis	MONDO:0005267	heart disorder	up-regulated	RT-qPCR	"In hypoxia-treated mouse cardiac fibroblasts, circHIPK3 is upregulated and promotes proliferation, migration, and fibroblast-to-myofibroblast phenotypic switching. It functions as a ceRNA by sponging miR-152-3p, thereby increasing TGF-beta2 expression and enhancing downstream fibrotic signaling."	0.6737
32904490	BioMed research international	2020	Circular RNA cir-ITCH Is a Potential Therapeutic Target for the Treatment of Castration-Resistant Prostate Cancer.	hsa_circ_0001141	cir-ITCH	hsa_circ_ITCH	ITCH	prostate cancer 	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR	"cir-ITCH (hsa_circ_0001141) is down-regulated in prostate cancer tissues and cell lines. Its overexpression suppresses PCa cell viability/proliferation, migration and invasion, and it negatively interacts with miR-17 while inhibiting Wnt/beta-catenin and PI3K/AKT/mTOR signaling activity, suggesting therapeutic potential for CRPC."	0.5732
32904557	BioMed research international	2020	The Significance of Circular RNA DDX17 in Prostate Cancer.		circDDX17 	hsa_circ_DDX17	DDX17	prostate cancer 	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR	"circDDX17 is down-regulated in prostate cancer tissues and functions as a tumor suppressor. It inhibits proliferation, invasion and EMT by sponging miR-346 and thereby increasing LHPP expression (circDDX17/miR-346/LHPP axis)."	0.7289
32904604	OncoTargets and therapy	2020	Circular RNA MYLK Promotes Hepatocellular Carcinoma Progression Through the miR29a/KMT5C Signaling Pathway.	hsa_circ_0002768	circMYLK	hsa_circ_MYLK	MYLK	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH	"circMYLK (hsa_circ_0002768) is up-regulated in HCC tissues and cell lines and predicts worse overall survival. It promotes HCC proliferation, migration/invasion, and metastasis while inhibiting apoptosis by sponging miR-29a to increase KMT5C expression."	0.7739
32908453	Cancer cell international	2020	circRAE1 promotes colorectal cancer cell migration and invasion by modulating miR-338-3p/TYRO3 axis.	hsa_circ_0060967	circRAE1 	hsa_circ_RAE1	RAE1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circRAE1 (Hsa_circ_0060967, from host gene RAE1) is up-regulated in colorectal cancer tissues and cell lines and promotes proliferation, migration and invasion. Mechanistically, it mainly localizes in the cytoplasm and functions as a ceRNA sponging miR-338-3p to derepress TYRO3, contributing to EMT-associated phenotypes."	0.7795
32908582	Computational and mathematical methods in medicine	2020	Construction of circRNA-Associated ceRNA Network Reveals Novel Biomarkers for Esophageal Cancer.	hsa_circ_0002255	circ_0002255			Esophageal cancer 	MONDO:0007576	esophageal cancer	unknown	RNA-seq	hsa_circ_0002255 was identified as a key circRNA in an ESCC-associated predicted ceRNA network. Functional enrichment suggested it is related to substrate adhesion-dependent cell spreading in ESCC.	0.1768
32908582	Computational and mathematical methods in medicine	2020	Construction of circRNA-Associated ceRNA Network Reveals Novel Biomarkers for Esophageal Cancer.	hsa_circ_0000530	circ_0000530			Esophageal cancer 	MONDO:0007576	esophageal cancer	unknown	RNA-seq	"circ_0000530 was identified as a key circRNA in the predicted ESCC ceRNA network, but the paper did not report a specific enriched function/pathway for this circRNA individually."	0.1768
32908582	Computational and mathematical methods in medicine	2020	Construction of circRNA-Associated ceRNA Network Reveals Novel Biomarkers for Esophageal Cancer.	hsa_circ_0001904	circ_0001904			Esophageal cancer 	MONDO:0007576	esophageal cancer	unknown	RNA-seq	"hsa_circ_0001904 was identified as a key circRNA regulator in ESCC through bioinformatics network construction, but no circ_0001904-specific function/pathway enrichment was reported in the provided text."	0.1768
32908582	Computational and mathematical methods in medicine	2020	Construction of circRNA-Associated ceRNA Network Reveals Novel Biomarkers for Esophageal Cancer.	hsa_circ_0001005	circ_0001005			Esophageal cancer 	MONDO:0007576	esophageal cancer	unknown	RNA-seq	circ_0001005 was identified as a key circRNA in the predicted ESCC ceRNA network; no circ_0001005-specific functional enrichment or clinical association was reported in the provided text.	0.1768
32908582	Computational and mathematical methods in medicine	2020	Construction of circRNA-Associated ceRNA Network Reveals Novel Biomarkers for Esophageal Cancer.	hsa_circ_0000513	circ_0000513			Esophageal cancer 	MONDO:0007576	esophageal cancer	unknown	RNA-seq	"hsa_circ_0000513 was identified as a key circRNA in ESCC via bioinformatics ceRNA network analysis. Enrichment results implicated it in adherens junction and ERBB/ErbB-related signaling regulation, potentially involving targets such as PTPRJ, SOS1, HIP1, PXN, and PIGU."	0.1768
32908582	Computational and mathematical methods in medicine	2020	Construction of circRNA-Associated ceRNA Network Reveals Novel Biomarkers for Esophageal Cancer.	hsa_circ_0000075	circ_0000075			Esophageal cancer 	MONDO:0007576	esophageal cancer	unknown	RNA-seq	hsa_circ_0000075 was identified as a key circRNA in ESCC based on RNA-seq and bioinformatics network analysis. Enrichment suggested associations with angiogenesis/blood vessel development and extrinsic apoptotic signaling-related processes.	0.1768
32908582	Computational and mathematical methods in medicine	2020	Construction of circRNA-Associated ceRNA Network Reveals Novel Biomarkers for Esophageal Cancer.	hsa_circ_0001121	circ_0001121			Esophageal cancer 	MONDO:0007576	esophageal cancer	unknown	RNA-seq	hsa_circ_0001121 was identified as a key circRNA in ESCC via bioinformatics ceRNA network analysis. Enrichment suggested its association with nucleocytoplasmic transport and protein export from nucleus-related processes.	0.1768
32908877	BioMed research international	2020	Bioinformatics Analysis of Key Genes and circRNA-miRNA-mRNA Regulatory Network in Gastric Cancer.	hsa_circ_0001013				Gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	Microarray	"This study identified hsa_circ_0001013 as up-regulated in gastric cancer based on GEO circRNA microarrays. Bioinformatics prediction suggests it may function as a ceRNA (e.g., sponging miR-182-5p/miR-145-5p/miR-758-3p) to regulate ECM/adhesion-related genes such as FBN1 and FN1, potentially influencing adhesion and metastasis and relating to PI3K-Akt and ECM-receptor interaction."	0.1768
32913142	Aging	2020	Profiling of circular RNAs in age-related cataract reveals circZNF292 as an antioxidant by sponging miR-23b-3p.	hsa_circ_0004058	circZNF292 	hsa_circ_ZNF292	ZNF292	age-related cataract 	MONDO:0004847	senile cataract	down-regulated	RT-qPCR; RNA-seq	"circZNF292 is down-regulated in ARC lens anterior capsule (and also in plasma) and acts as an antioxidant-related circRNA. It functions as a ceRNA by sponging miR-23b-3p, thereby de-repressing anti-oxidative genes (e.g., GPX3, SIRT1, PRDX6, ALDH6A1, SOD1) and potentially reducing oxidative stress-induced apoptosis of lens epithelial cells."	0.5135
32913142	Aging	2020	Profiling of circular RNAs in age-related cataract reveals circZNF292 as an antioxidant by sponging miR-23b-3p.	hsa_circ_0060144	chr20:34389413-34459751+	hsa_circ_PHF20	PHF20	age-related cataract 	MONDO:0004847	senile cataract	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0060144 (PHF20-derived) is identified as a significantly down-regulated candidate circRNA in ARC anterior lens capsules. It was selected based on having miR-23b-3p response elements and validated for differential expression by qRT-PCR, suggesting a possible role in an ARC-related circRNA_miR-23b-3p network."	0.4032
32913142	Aging	2020	Profiling of circular RNAs in age-related cataract reveals circZNF292 as an antioxidant by sponging miR-23b-3p.	hsa_circ_0122396	chr3:150903117-150911453+	hsa_circ_MED12L	MED12L	age-related cataract 	MONDO:0004847	senile cataract	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0122396 (MED12L-derived) is identified as a significantly down-regulated candidate circRNA in ARC anterior lens capsules. It was selected due to predicted miR-23b-3p response elements and its differential expression was verified by qRT-PCR, indicating involvement in a candidate circRNA_miR-23b-3p network in ARC."	0.4032
32913183	Cell death & disease	2020	UBAC2 promotes bladder cancer proliferation through BCRC-3/miRNA-182-5p/p27 axis.		BCRC-3 			bladder cancer 	MONDO:0004986	urinary bladder carcinoma	unknown	RT-qPCR	"In bladder cancer cells, BCRC-3 participates in the BCRC-3/miR-182-5p/p27 ceRNA axis and suppresses proliferation by supporting p27 expression. UBAC2 directly binds BCRC-3 and reduces its miR-182-5p sponging capacity, thereby decreasing p27 and promoting cell-cycle progression."	0.7261
32913938	Non-coding RNA research	2020	Integrated analysis of circRNA-miRNA-mRNA regulatory network identifies potential diagnostic biomarkers in diabetic foot ulcer.	hsa_circ_0089761				diabetic foot ulcer 	MONDO:0000960	diabetic peripheral angiopathy	dysregulated	Microarray	hsa_circ_0089761 was identified as a differentially expressed circRNA included in a DFU-specific circRNA_miRNA_mRNA ceRNA network constructed from GEO microarray datasets. Its functional/clinical role was not experimentally validated and was proposed as a potential diagnostic biomarker/therapeutic target requiring further study.	0.1768
32913938	Non-coding RNA research	2020	Integrated analysis of circRNA-miRNA-mRNA regulatory network identifies potential diagnostic biomarkers in diabetic foot ulcer.	hsa_circ_0089762				diabetic foot ulcer 	MONDO:0000960	diabetic peripheral angiopathy	dysregulated	Microarray	hsa_circ_0089762 was one of eight differentially expressed circRNAs included in a DFU-associated circRNA_miRNA_mRNA ceRNA network derived from GEO datasets. No specific downstream miRNA/mRNA axis or experimental validation was reported for this circRNA.	0.1768
32913938	Non-coding RNA research	2020	Integrated analysis of circRNA-miRNA-mRNA regulatory network identifies potential diagnostic biomarkers in diabetic foot ulcer.	hsa_circ_0001222		hsa_circ_FBXO7	FBXO7	diabetic foot ulcer 	MONDO:0000960	diabetic peripheral angiopathy	dysregulated	Microarray	hsa_circ_0001222 (host gene FBXO7) was included among the differentially expressed circRNAs used to build a DFU-associated ceRNA network from GEO datasets. The study did not report a specific validated miRNA/mRNA axis or functional experiments for this circRNA.	0.1768
32913938	Non-coding RNA research	2020	Integrated analysis of circRNA-miRNA-mRNA regulatory network identifies potential diagnostic biomarkers in diabetic foot ulcer.	hsa_circ_0089763				diabetic foot ulcer 	MONDO:0000960	diabetic peripheral angiopathy	dysregulated	Microarray	"hsa_circ_0089763 was identified as a differentially expressed circRNA within a DFU-specific ceRNA network built from GEO datasets. The paper proposed it as a potential diagnostic biomarker/therapeutic target, but did not provide experimental validation or a specific interaction axis in the provided text."	0.1768
32913938	Non-coding RNA research	2020	Integrated analysis of circRNA-miRNA-mRNA regulatory network identifies potential diagnostic biomarkers in diabetic foot ulcer.	hsa_circ_0000711		hsa_circ_NFATC3	NFATC3	diabetic foot ulcer 	MONDO:0000960	diabetic peripheral angiopathy	dysregulated	Microarray	hsa_circ_0000711 (host gene NFATC3) was one of the eight differentially expressed circRNAs used to construct a DFU-related ceRNA network using GEO datasets. The article did not report specific validated interacting miRNAs/mRNAs or functional experiments for this circRNA.	0.1768
32913938	Non-coding RNA research	2020	Integrated analysis of circRNA-miRNA-mRNA regulatory network identifies potential diagnostic biomarkers in diabetic foot ulcer.	hsa_circ_0001714		hsa_circ_BAZ1B	BAZ1B	diabetic foot ulcer 	MONDO:0000960	diabetic peripheral angiopathy	dysregulated	Microarray	hsa_circ_0001714 (host gene BAZ1B) was identified as a differentially expressed circRNA incorporated into a DFU ceRNA network constructed via GEO datasets and database predictions. No circRNA-specific functional validation or explicit downstream targets were provided in the text.	0.1768
32913938	Non-coding RNA research	2020	Integrated analysis of circRNA-miRNA-mRNA regulatory network identifies potential diagnostic biomarkers in diabetic foot ulcer.	hsa_circ_0000437		hsa_circ_CORO1C	CORO1C	diabetic foot ulcer 	MONDO:0000960	diabetic peripheral angiopathy	dysregulated	Microarray	hsa_circ_0000437 (host gene CORO1C) was identified as a differentially expressed circRNA and included in the DFU ceRNA network built from GEO data and interaction predictions. The paper did not report specific validated targets or experimental functional assays for this circRNA.	0.1768
32913938	Non-coding RNA research	2020	Integrated analysis of circRNA-miRNA-mRNA regulatory network identifies potential diagnostic biomarkers in diabetic foot ulcer.	hsa_circ_0000288		hsa_circ_CAPRIN1	CAPRIN1	diabetic foot ulcer 	MONDO:0000960	diabetic peripheral angiopathy	dysregulated	Microarray	hsa_circ_0000288 (host gene CAPRIN1) was one of the differentially expressed circRNAs used to build a DFU-related ceRNA network via integrative bioinformatics analysis of GEO datasets. The paper did not provide circRNA-specific functional experiments or validated interaction partners beyond the predicted network context.	0.1768
32916598	Molecular therapy. Nucleic acids	2020	ZEB1-Mediated Transcriptional Upregulation of circWWC3 Promotes Breast Cancer Progression through Activating Ras Signaling Pathway.	hsa_circ_0001910	circWWC3	hsa_circ_WWC3	WWC3	breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; ISH; Microarray	"In breast cancer, circWWC3 (hsa_circ_0001910) is upregulated and mainly localized in the cytoplasm. It promotes proliferation, migration, invasion, and in vivo growth/metastasis by sponging miR-26b-3p and miR-660-3p, thereby activating the Ras signaling pathway (e.g., increasing EGFR/GRB2/PAK4/MAPK1/AKT1 protein levels). High circWWC3 expression is associated with advanced clinical stage and poor overall survival."	0.8961
32917240	Molecular cancer	2020	Circular HER2 RNA positive triple negative breast cancer is sensitive to Pertuzumab.	hsa_circ_0007766	circ-HER2 	hsa_circ_HER2	HER2	triple negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; Northern Blot; RNA-seq	"In TNBC, circ-HER2 (hsa_circ_0007766) is up-regulated in a subset of patients and is translated into the peptide/protein HER2_103. HER2_103 promotes EGFR/EGFR and EGFR/HER3 dimerization, enhances EGFR kinase activity and sustains AKT phosphorylation, thereby promoting proliferation, invasion/migration and tumorigenesis; circ-HER2 positivity associates with worse overall survival and predicts sensitivity to Pertuzumab in preclinical xenograft models."	0.8956
32917870	Nature communications	2020	Spatial expression analyses of the putative oncogene ciRS-7 in cancer reshape the microRNA sponge theory.		ciRS-7 	hsa_circ_LINC00632	LINC00632	colon cancer 	MONDO:0021063	malignant colon neoplasm	dysregulated	RT-qPCR; ISH; RNA-seq	"In colon cancer tissues, ciRS-7 is not expressed in cancer cells but is abundant in tumor stromal cells. The study argues that bulk-tissue correlations between ciRS-7 and putative miR-7 target genes can be driven by variable cancer-to-stromal cell ratios rather than ceRNA (miR-7 sponge) activity, supported by ciRS-7 knockout and reporter assays in HEK293T cells."	0.6103
32922032	OncoTargets and therapy	2020	Construction of a circRNA-Related ceRNA Prognostic Regulatory Network in Breast Cancer.	hsa_circ_0062682		hsa_circ_TPST2	TPST2	breast cancer	MONDO:0007254	breast cancer	up-regulated	Microarray	"hsa_circ_0062682 is identified as an upregulated differentially expressed circRNA in breast cancer based on circRNA microarray profiling. It is included in the study¡¯s predicted circRNA-related ceRNA framework, but no circRNA-specific mechanism or clinical association is experimentally validated."	0.1768
32922032	OncoTargets and therapy	2020	Construction of a circRNA-Related ceRNA Prognostic Regulatory Network in Breast Cancer.	hsa_circ_0007798		hsa_circ_MAP3K5	MAP3K5	breast cancer	MONDO:0007254	breast cancer	up-regulated	Microarray	"hsa_circ_0007798 is identified as an upregulated differentially expressed circRNA in breast cancer using circRNA microarray data. It is part of the study¡¯s predicted circRNA_miRNA_mRNA ceRNA network, without circRNA-specific experimental validation of mechanism or prognosis."	0.1768
32922032	OncoTargets and therapy	2020	Construction of a circRNA-Related ceRNA Prognostic Regulatory Network in Breast Cancer.	hsa_circ_0092342		hsa_circ_RPL27A	RPL27A	breast cancer	MONDO:0007254	breast cancer	down-regulated	Microarray	"hsa_circ_0092342 is identified as a downregulated differentially expressed circRNA in breast cancer from circRNA microarray profiling. It is considered within a predicted circRNA_miRNA_mRNA ceRNA regulatory framework, but no circRNA-specific functional mechanism is experimentally validated."	0.1768
32922032	OncoTargets and therapy	2020	Construction of a circRNA-Related ceRNA Prognostic Regulatory Network in Breast Cancer.	hsa_circ_0065173		hsa_circ_SETD2	SETD2	breast cancer	MONDO:0007254	breast cancer	down-regulated	Microarray	"hsa_circ_0065173 is a downregulated differentially expressed circRNA in breast cancer in this microarray-based analysis. The paper notes it was previously reported as altered in breast cancer and includes it within a predicted circRNA-related ceRNA regulatory network, but provides no circRNA-specific experimental validation."	0.1768
32922033	OncoTargets and therapy	2020	"Downregulation of Hsa_circ_0000735 Inhibits the Proliferation, Migration, Invasion, and Glycolysis in Non-small-cell Lung Cancer by Targeting miR-940/BMPER Axis."	hsa_circ_0000735	circ_0000735	hsa_circ_P2RX1	P2RX1	Non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0000735 is upregulated in NSCLC and functions as an oncogenic circRNA, promoting proliferation, migration, invasion, glycolysis, and xenograft tumor growth. Mechanistically, it primarily localizes to the cytoplasm and regulates BMPER expression by sponging miR-940, forming a circ_0000735/miR-940/BMPER axis associated with poor patient survival."	0.7855
32922040	OncoTargets and therapy	2020	Comprehensive Analysis of circRNA-miRNA-mRNA Network in Cervical Squamous Cell Carcinoma by Integrated Analysis.	hsa_circ_0000069				Cervical squamous cell carcinoma 	MONDO:0006143	cervical squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000069 is up-regulated in CSCC and may function as a ceRNA by sponging hsa-miR-125b-5p, thereby relating to CDKN2A within the proposed circRNA_miRNA_mRNA axis in CSCC."	0.4032
32922040	OncoTargets and therapy	2020	Comprehensive Analysis of circRNA-miRNA-mRNA Network in Cervical Squamous Cell Carcinoma by Integrated Analysis.	hsa_circ_0020594				Cervical squamous cell carcinoma 	MONDO:0006143	cervical squamous cell carcinoma	unknown	Microarray	"hsa_circ_0020594 is proposed (based on integrated bioinformatics analysis) to participate in CSCC via a ceRNA axis involving hsa-let-7c-5p and the downstream gene CCNB2, but its expression direction and experimental validation were not reported."	0.1768
32922071	Cancer management and research	2020	Circular RNA circRNA_103809 Accelerates Bladder Cancer Progression and Enhances Chemo-Resistance by Activation of miR-516a-5p/FBXL18 Axis.		circRNA_103809			bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circRNA_103809 is up-regulated in bladder cancer tissues/cell lines and its high expression correlates with worse OS and PFS. Functionally, it promotes proliferation, migration/invasion and gemcitabine chemo-resistance by sponging miR-516a-5p to increase FBXL18 expression."	0.7078
32922073	Cancer management and research	2020	"Circ_0000376, a Novel circRNA, Promotes the Progression of Non-Small Cell Lung Cancer Through Regulating the miR-1182/NOVA2 Network."	hsa_circ_0000376	circ_0000376			non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0000376 is up-regulated in NSCLC and is further induced by hypoxia. Functionally, it promotes glycolysis and malignant phenotypes (viability, migration, invasion) and supports tumor growth. Mechanistically, it acts as a ceRNA that sponges miR-1182 to increase NOVA2 expression, forming a circ_0000376/miR-1182/NOVA2 axis associated with poor overall survival."	0.8162
32922078	Cancer management and research	2020	"Blocking circ_0000520 Suppressed Breast Cancer Cell Growth, Migration and Invasion Partially via miR-1296/SP1 Axis Both in vitro and in vivo."	hsa_circ_0000520	circ_0000520	hsa_circ_RPPH1	RPPH1	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"In breast cancer, circ_0000520 is up-regulated and functions as an oncogenic circRNA that promotes proliferation, migration, invasion and tumor growth while inhibiting apoptosis. Mechanistically, it is mainly cytoplasmic and acts as a miRNA sponge for miR-1296-5p, thereby relieving miR-1296-mediated repression of SP1 (circ_0000520/miR-1296/SP1 axis). High circ_0000520 expression is associated with worse overall survival."	0.8256
32922436	Frontiers in genetics	2020	Identification of Prostate Cancer-Related Circular RNA Through Bioinformatics Analysis.	hsa_circ_0024353		hsa_circ_APOC3	APOC3	Prostate cancer 	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0024353 is down-regulated in PC-3 prostate cancer cells versus RWPE-1. Bioinformatics predicts it may act in a circRNA_miRNA_mRNA network by sponging miR-940 and miR-1253 to regulate PDE7B and DMRT2, respectively, with downstream genes enriched in pathways including PI3K-Akt, HIF-1, p53, and cell cycle."	0.3858
32922436	Frontiers in genetics	2020	Identification of Prostate Cancer-Related Circular RNA Through Bioinformatics Analysis.	hsa_circ_0085494		hsa_circ_TMEM65	TMEM65	Prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0085494 is up-regulated in PC-3 prostate cancer cells versus RWPE-1. Bioinformatics predicts a circRNA_miRNA_mRNA axis hsa_circ_0085494/miR-330-3p/TGFBR3, and enrichment suggests involvement of PI3K-Akt and AMPK-related signaling."	0.3858
32922436	Frontiers in genetics	2020	Identification of Prostate Cancer-Related Circular RNA Through Bioinformatics Analysis.	hsa_circ_0031408		hsa_circ_STXBP6	STXBP6	Prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0031408 is up-regulated in PC-3 prostate cancer cells versus RWPE-1. Its miRNA response elements and potential target genes were predicted bioinformatically, with enrichment including cell-cycle-related pathways, but no specific downstream miRNA_mRNA axis was highlighted as a main predicted axis in the paper."	0.3858
32926734	Neuro-oncology	2021	EIF4A3-induced circular RNA ASAP1 promotes tumorigenesis and temozolomide resistance of glioblastoma via NRAS/MEK1/ERK1-2 signaling.	hsa_circ_0002330	circASAP1	hsa_circ_ASAP1	ASAP1	glioblastoma 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; RNA-seq	"circASAP1 is up-regulated in recurrent glioblastoma and TMZ-resistant GBM cells, promotes proliferation and temozolomide resistance, and inhibits TMZ-induced apoptosis. Mechanistically, circASAP1 acts as a ceRNA to sponge miR-502-5p, thereby increasing NRAS expression and activating the NRAS/MEK1/ERK1-2 signaling pathway; its biogenesis is promoted by EIF4A3 binding to flanking sequences. High circASAP1 expression is associated with worse overall survival after TMZ treatment."	0.8816
32927434	Aging	2020	High hsa_circ_0020123 expression indicates poor progression to non-small cell lung cancer by regulating the miR-495/HOXC9 axis.	hsa_circ_0020123		hsa_circ_PDZD8	PDZD8	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; ISH	"hsa_circ_0020123 is up-regulated in NSCLC tissues and cell lines and mainly localizes to the cytoplasm. It promotes NSCLC proliferation, migration/invasion and xenograft tumor growth by sponging miR-495 and thereby increasing HOXC9 expression, forming a hsa_circ_0020123/miR-495/HOXC9 axis. High expression associates with worse overall survival, supporting a prognostic/therapeutic relevance."	0.7628
32928266	Journal of experimental & clinical cancer research : CR	2020	Hsa_circ_0001944 promotes the growth and metastasis in bladder cancer cells by acting as a competitive endogenous RNA for miR-548.	hsa_circ_0001944				bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"hsa_circ_0001944 is up-regulated in bladder cancer tissues and cell lines and promotes proliferation, invasion, and metastasis. Mechanistically, it functions as a ceRNA by sponging miR-548 to increase PROK2 expression, and high hsa_circ_0001944 levels are associated with poor overall survival."	0.7927
32929374	Theranostics	2020	circ-PRKCB acts as a ceRNA to regulate p66Shc-mediated oxidative stress in intestinal ischemia/reperfusion.			hsa_circ_PRKCB	PRKCB	intestinal ischemia	MONDO:0004613	acute intestinal ischemia	up-regulated	RT-qPCR	"circ-PRKCB is upregulated in murine intestinal I/R and in ischemic intestinal tissues from patients with intestinal infarction. It mainly localizes to the cytoplasm and acts as a ceRNA sponge for miR-339-5p, relieving repression of p66Shc and promoting oxidative stress/ROS accumulation. Silencing circ-PRKCB reduces p66Shc and attenuates oxidative damage and intestinal I/R injury in vitro and in vivo."	0.8203
32929374	Theranostics	2020	circ-PRKCB acts as a ceRNA to regulate p66Shc-mediated oxidative stress in intestinal ischemia/reperfusion.	mmu_circ_0013842		mmu_circ_Prkcb	Prkcb	intestinal ischemia	MONDO:0004613	acute intestinal ischemia	up-regulated	RT-qPCR	"circ-PRKCB is upregulated in murine intestinal I/R and in ischemic intestinal tissues from patients with intestinal infarction. It mainly localizes to the cytoplasm and acts as a ceRNA sponge for miR-339-5p, relieving repression of p66Shc and promoting oxidative stress/ROS accumulation. Silencing circ-PRKCB reduces p66Shc and attenuates oxidative damage and intestinal I/R injury in vitro and in vivo."	0.8203
32929380	Theranostics	2020	circPTCH1 promotes invasion and metastasis in renal cell carcinoma via regulating miR-485-5p/MMP14 axis.	hsa_circ_0139402	circPTCH1	hsa_circ_PTCH1	PTCH1	renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR; Microarray	"circPTCH1 (hsa_circ_0139402), derived from PTCH1, is up-regulated in RCC and promotes migration, invasion, and metastasis. It functions mainly in the cytoplasm as a ceRNA that sponges miR-485-5p to increase MMP14 expression and drive EMT, and high circPTCH1 levels are associated with worse patient survival."	0.8931
32938310	Technology in cancer research & treatment	2020	circUSP42 Is Downregulated in Triple-Negative Breast Cancer and Associated With Poor Prognosis.	hsa_circ_0002032				triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0002032 was identified as an upregulated circRNA in TNBC tissues and was predicted (bioinformatically) to sponge miR-182; its downstream targets and functional effects were not experimentally characterized in this study.	0.4685
32938310	Technology in cancer research & treatment	2020	circUSP42 Is Downregulated in Triple-Negative Breast Cancer and Associated With Poor Prognosis.		chr6:131973682-132047340+			triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; RNA-seq	"The circRNA denoted by chr6:131973682-132047340+ was identified as upregulated in TNBC and predicted to sponge miR-182; no host gene, downstream targets, or functional assays were reported specifically for this circRNA."	0.4685
32938310	Technology in cancer research & treatment	2020	circUSP42 Is Downregulated in Triple-Negative Breast Cancer and Associated With Poor Prognosis.	hsa_circ_0005982				triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005982 was found upregulated in TNBC tissues and predicted to sponge miR-182, but the study did not experimentally define its downstream effectors or cellular phenotypes."	0.4685
32938310	Technology in cancer research & treatment	2020	circUSP42 Is Downregulated in Triple-Negative Breast Cancer and Associated With Poor Prognosis.	hsa_circ_0007823	circUSP42	hsa_circ_USP42	USP42	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	down-regulated	RT-qPCR; RNA-seq	"circUSP42 (hsa_circ_0007823), derived from USP42, is downregulated in TNBC tissues and its low expression correlates with lymph node metastasis, advanced stage, and worse DFS/OS. It is predicted to sponge miR-182/miR-182-5p, but downstream targets and signaling pathways were not experimentally defined."	0.559
32938310	Technology in cancer research & treatment	2020	circUSP42 Is Downregulated in Triple-Negative Breast Cancer and Associated With Poor Prognosis.	hsa_circ_0001777				triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001777 was identified as downregulated in TNBC and predicted to sponge miR-182; the study did not provide circRNA-specific downstream targets, pathway involvement, or clinical outcome association for this circRNA."	0.4685
32940102	The Journal of international medical research	2020	Circular RNA circ-NCOR2 accelerates papillary thyroid cancer progression by sponging miR-516a-5p to upregulate metastasis-associated protein 2 expression.	hsa_circ_0000461	circ-NCOR2	hsa_circ_NCOR2	NCOR2	papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circ-NCOR2 (hsa_circ_0000461) is up-regulated in papillary thyroid cancer tissues and cell lines. It mainly localizes in the cytoplasm and promotes proliferation, migration and invasion while inhibiting apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-516a-5p to increase MTA2 expression, forming a circ-NCOR2/miR-516a-5p/MTA2 axis."	0.6829
32943916	Cancer management and research	2020	Circ-ZNF609 Accelerates the Radioresistance of Prostate Cancer Cells by Promoting the Glycolytic Metabolism Through miR-501-3p/HK2 Axis.		circ-ZNF609 	hsa_circ_ZNF609		prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circ-ZNF609 is up-regulated in prostate cancer tissues and cell lines and promotes malignant phenotypes and radioresistance. Mechanistically, it sponges miR-501-3p to increase HK2 expression, enhancing glycolysis and thereby decreasing radiosensitivity; circ-ZNF609 knockdown reverses these effects in vitro and in xenograft tumors."	0.705
32943917	Cancer management and research	2020	Exosomal CircGDI2 Suppresses Oral Squamous Cell Carcinoma Progression Through the Regulation of MiR-424-5p/SCAI Axis.	hsa_circ_0005379	circGDI2	hsa_circ_GDI2	GDI2	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR	"In OSCC, circGDI2 is down-regulated and can be transported via exosomes. Exosomal circGDI2 suppresses malignant behaviors (proliferation, migration, invasion) and glycolysis by sponging miR-424-5p, thereby increasing SCAI expression, and it inhibits tumor growth in vivo."	0.721
32943922	Cancer management and research	2020	"Exosomal Circ-ZNF652 Promotes Cell Proliferation, Migration, Invasion and Glycolysis in Hepatocellular Carcinoma via miR-29a-3p/GUCD1 Axis."		circ-ZNF652 	hsa_circ_ZNF652	ZNF652	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"Exosomal circ-ZNF652 is up-regulated in HCC patient serum exosomes and HCC cells. It mainly localizes in the cytoplasm and promotes proliferation, migration, invasion, glycolysis and in vivo tumor growth by sponging miR-29a-3p to upregulate GUCD1 (with downstream effects including HK2-associated glycolysis)."	0.762
32944002	Cancer cell international	2020	"CircUBE2D2 (hsa_circ_0005728) promotes cell proliferation, metastasis and chemoresistance in triple-negative breast cancer by regulating miR-512-3p/CDCA3 axis."	hsa_circ_0005728	CircUBE2D2	hsa_circ_UBE2D2	UBE2D2	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"circUBE2D2 (hsa_circ_0005728) is up-regulated in TNBC and mainly localized in the cytoplasm. It promotes malignant phenotypes (proliferation, migration/invasion, tumor growth) and doxorubicin chemoresistance by sponging miR-512-3p, thereby up-regulating CDCA3."	0.8591
32945389	International journal of molecular medicine	2020	Circular RNA circ_0010283 regulates the viability and migration of oxidized low_density lipoprotein_induced vascular smooth muscle cells via an miR_370_3p/HMGB1 axis in atherosclerosis.	hsa_circ_0010283	circ_0010283	hsa_circ_UBR4	UBR4	atherosclerosis	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"circ_0010283 is upregulated in ox-LDL-induced human VSMCs and mainly localizes to the cytoplasm. It promotes VSMC viability and migration by sponging miR-370-3p, thereby relieving repression of HMGB1 (circ_0010283/miR-370-3p/HMGB1 axis) in an in vitro atherosclerosis model."	0.6865
32951448	Cell transplantation	2020	Circ_0000079 Decoys the RNA-Binding Protein FXR1 to Interrupt Formation of the FXR1/PRCKI Complex and Decline Their Mediated Cell Invasion and Drug Resistance in NSCLC.	hsa_circ_0000079	circ_0000079 	hsa_circ_USP1	USP1	nonsmall cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"circ_0000079 (hsa_circ_0000079, from USP1) is down-regulated in NSCLC, particularly in cisplatin-resistant cases, and low expression is associated with worse overall survival. Functionally, circ_0000079 suppresses proliferation, invasion, and cisplatin resistance by binding/decoying FXR1, disrupting the FXR1/PRKCI complex and reducing downstream signaling that supports EMT and drug resistance."	0.841
32951449	Cell transplantation	2020	Hsa_circ_002178 Promotes the Growth and Migration of Breast Cancer Cells and Maintains Cancer Stem-like Cell Properties Through Regulating miR-1258/KDM7A Axis.		hsa_circ_002178 			breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; ISH; Microarray	"hsa_circ_002178 is up-regulated in breast cancer tissues and cell lines and is associated with worse survival and aggressive clinicopathological features. Functionally, it promotes proliferation, invasion/migration and cancer stem-like properties. Mechanistically, it sponges miR-1258 to relieve repression of KDM7A, supporting tumor growth and metastasis in vitro and in a xenograft model."	0.8239
32952599	Computational and mathematical methods in medicine	2020	Comprehensive Analysis of Differentially Expressed circRNAs Reveals a Colorectal Cancer-Related ceRNA Network.	hsa_circ_0004841				colorectal cancer 	MONDO:0005575	colorectal cancer	unknown	RNA-seq	"hsa_circ_0004841 was identified by ceRNA network analysis as a key circRNA in colorectal cancer, being connected to >10 predicted miRNAs within the circRNA-miRNA-mRNA network."	0.1768
32952599	Computational and mathematical methods in medicine	2020	Comprehensive Analysis of Differentially Expressed circRNAs Reveals a Colorectal Cancer-Related ceRNA Network.	hsa_circ_0007523				colorectal cancer 	MONDO:0005575	colorectal cancer	unknown	RNA-seq	"hsa_circ_0007523 was identified by ceRNA network analysis as a key circRNA in colorectal cancer, being connected to >10 predicted miRNAs within the circRNA-miRNA-mRNA network."	0.1768
32952599	Computational and mathematical methods in medicine	2020	Comprehensive Analysis of Differentially Expressed circRNAs Reveals a Colorectal Cancer-Related ceRNA Network.	hsa_circ_0008038				colorectal cancer 	MONDO:0005575	colorectal cancer	unknown	RNA-seq	"hsa_circ_0008038 was identified by ceRNA network analysis as a key circRNA in colorectal cancer, being connected to >10 predicted miRNAs within the circRNA-miRNA-mRNA network."	0.1768
32952599	Computational and mathematical methods in medicine	2020	Comprehensive Analysis of Differentially Expressed circRNAs Reveals a Colorectal Cancer-Related ceRNA Network.	hsa_circ_0000799				colorectal cancer 	MONDO:0005575	colorectal cancer	unknown	RNA-seq	"hsa_circ_0000799 was identified by ceRNA network analysis as a key circRNA in colorectal cancer, being connected to >10 predicted miRNAs within the circRNA-miRNA-mRNA network."	0.1768
32952599	Computational and mathematical methods in medicine	2020	Comprehensive Analysis of Differentially Expressed circRNAs Reveals a Colorectal Cancer-Related ceRNA Network.	hsa_circ_0002744				colorectal cancer 	MONDO:0005575	colorectal cancer	unknown	RNA-seq	"hsa_circ_0002744 was identified by ceRNA network analysis as a key circRNA in colorectal cancer, being connected to >10 predicted miRNAs within the circRNA-miRNA-mRNA network."	0.1768
32952599	Computational and mathematical methods in medicine	2020	Comprehensive Analysis of Differentially Expressed circRNAs Reveals a Colorectal Cancer-Related ceRNA Network.	hsa_circ_0005620				colorectal cancer 	MONDO:0005575	colorectal cancer	unknown	RNA-seq	"hsa_circ_0005620 was identified by ceRNA network analysis as a key circRNA in colorectal cancer, being connected to >10 predicted miRNAs within the circRNA-miRNA-mRNA network."	0.1768
32953799	Annals of translational medicine	2020	"CircRNA-0008717 promotes cell proliferation, migration, and invasion by regulating miR-203/Slug in esophageal cancer cells."	hsa_circ_0008717	circRNA-0008717			esophageal cancer 	MONDO:0007576	esophageal cancer	up-regulated	RT-qPCR	"In esophageal cancer cell lines, circRNA-0008717 is up-regulated and promotes malignant phenotypes (proliferation, migration, invasion) while reducing apoptosis. Mechanistically, it sponges miR-203, thereby relieving repression of Slug and modulating EMT-related markers (vimentin and E-cadherin)."	0.5992
32954174	ACS omega	2020	CircRNA CircRIMS Acts as a MicroRNA Sponge to Promote Gastric Cancer Metastasis.		circRIMS			gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"circRIMS is up-regulated in metastasis-prone gastric cancer tissues (higher in T3N3M0 than T3N1M0) and promotes GC cell migration, invasion, and in vivo metastatic burden. Mechanistically, it functions as a miRNA sponge for hsa-miR-148a-5p and hsa-miR-218-5p, and miRNA mimics can rescue/reverse the pro-metastatic phenotype. It is proposed as a potential early biomarker for predicting invasive metastasis in GC."	0.8754
32960511	Journal of cellular and molecular medicine	2020	Circ_0007331 knock-down suppresses the progression of endometriosis via miR-200c-3p/HiF-1alpha axis.	hsa_circ_0007331	circ_0007331			endometriosis 	MONDO:0005133	endometriosis	up-regulated	RT-qPCR	"circ_0007331 is up-regulated in endometriosis endometrial samples and ectopic endometrial cells. Its knockdown suppresses ectopic endometrial cell viability/proliferation/invasion and reduces lesion growth in a mouse model. Mechanistically, circ_0007331 sponges miR-200c-3p to increase HIF-1alpha, forming a circ_0007331/miR-200c-3p/HIF-1alpha regulatory axis."	0.7126
32963582	Computational and mathematical methods in medicine	2020	Circular RNA CircITGA7 Promotes Tumorigenesis of Osteosarcoma via miR-370/PIM1 Axis.		CircITGA7	hsa_circ_ITGA7	ITGA7	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circITGA7 is up-regulated in osteosarcoma tissues and OS cell lines and promotes malignant phenotypes (proliferation, migration, invasion). Mechanistically, circITGA7 functions as a ceRNA to sponge miR-370, thereby relieving repression of PIM1 and driving OS progression."	0.6369
32964035	BioMed research international	2020	SRCIN1 Regulated by circCCDC66/miR-211 Is Upregulated and Promotes Cell Proliferation in Non-Small-Cell Lung Cancer.		circCCDC66 	hsa_circ_CCDC66		non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	unknown	RT-qPCR	"circCCDC66 promotes NSCLC cell proliferation in vitro. Mechanistically, it acts as a ceRNA/miRNA sponge for miR-211, thereby relieving miR-211-mediated suppression of SRCIN1 and supporting the miR-211/SRCIN1 axis."	0.4712
32965791	FEBS open bio	2020	Circular RNAs associated with a mouse model of concanavalin A-induced autoimmune hepatitis: preliminary screening and comprehensive functional analysis.	mmu_circ_0000700		mmu_circ_Robo2	Robo2	autoimmune hepatitis 	MONDO:0016264	autoimmune hepatitis	up-regulated	RT-qPCR; Microarray	mmu_circ_0000700 is up-regulated in liver tissue from a Con A-induced AIH mouse model and was validated by qRT-PCR after microarray screening. No specific downstream miRNA/mRNA mechanism was established for this circRNA in the study.	0.4625
32965791	FEBS open bio	2020	Circular RNAs associated with a mouse model of concanavalin A-induced autoimmune hepatitis: preliminary screening and comprehensive functional analysis.	mmu_circ_0001335		mmu_circ_Nsd2	Nsd2	autoimmune hepatitis 	MONDO:0016264	autoimmune hepatitis	up-regulated	RT-qPCR; Microarray	"mmu_circ_0001335 is up-regulated in liver tissue in a Con A-induced AIH mouse model, with expression validated by qRT-PCR following microarray screening. The study did not report a specific miRNA/mRNA regulatory mechanism for this circRNA."	0.4625
32965791	FEBS open bio	2020	Circular RNAs associated with a mouse model of concanavalin A-induced autoimmune hepatitis: preliminary screening and comprehensive functional analysis.	mmu_circ_0001843		mmu_circ_Qrich1	Qrich1	autoimmune hepatitis 	MONDO:0016264	autoimmune hepatitis	up-regulated	RT-qPCR; Microarray	"mmu_circ_0001843 is up-regulated in liver tissue in a Con A-induced AIH mouse model, and its differential expression was validated by qRT-PCR after microarray profiling. No specific downstream interaction axis was defined for this circRNA in the paper."	0.4625
32965791	FEBS open bio	2020	Circular RNAs associated with a mouse model of concanavalin A-induced autoimmune hepatitis: preliminary screening and comprehensive functional analysis.	mmu_circ_0000607		mmu_circ_Zfat	Zfat	autoimmune hepatitis 	MONDO:0016264	autoimmune hepatitis	down-regulated	RT-qPCR; Microarray	"mmu_circ_0000607 is down-regulated in liver tissue in a Con A-induced AIH mouse model, and this change was supported by qRT-PCR validation of the microarray result. The study did not specify a downstream regulatory axis for this circRNA."	0.4625
32965791	FEBS open bio	2020	Circular RNAs associated with a mouse model of concanavalin A-induced autoimmune hepatitis: preliminary screening and comprehensive functional analysis.	mmu_circ_0001816				autoimmune hepatitis 	MONDO:0016264	autoimmune hepatitis	down-regulated	RT-qPCR; Microarray	"mmu_circ_0001816 (an intergenic circRNA) is down-regulated in liver tissue in a Con A-induced AIH mouse model, supported by qRT-PCR validation of microarray findings. The paper did not provide a specific interaction network or mechanism for this circRNA."	0.4625
32965791	FEBS open bio	2020	Circular RNAs associated with a mouse model of concanavalin A-induced autoimmune hepatitis: preliminary screening and comprehensive functional analysis.	mmu_circ_0001815				autoimmune hepatitis 	MONDO:0016264	autoimmune hepatitis	down-regulated	RT-qPCR; Microarray	mmu_circ_0001815 (an intergenic circRNA) is down-regulated in liver tissue in a Con A-induced AIH mouse model and was validated by qRT-PCR after microarray screening. No specific downstream mechanism was established for this circRNA.	0.4625
32965791	FEBS open bio	2020	Circular RNAs associated with a mouse model of concanavalin A-induced autoimmune hepatitis: preliminary screening and comprehensive functional analysis.	mmu_circ_0001520		mmu_circ_C1s		autoimmune hepatitis 	MONDO:0016264	autoimmune hepatitis	up-regulated	RT-qPCR; Microarray	"mmu_circ_0001520 is up-regulated in liver in a Con A-induced AIH mouse model. The study proposes and partially validates a ceRNA axis where mmu_circ_0001520 sponges mmu-miR-193b-3p, associated with increased MAPK10 expression, potentially contributing to AIH progression."	0.4474
32968054	Cell death & disease	2020	Circular RNA GLIS2 promotes colorectal cancer cell motility via activation of the NF-kappaB pathway.		circGLIS2 	hsa_circ_GLIS2	GLIS2	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circGLIS2 is upregulated in colorectal cancer tissues and cell lines and promotes CRC cell migration. Mechanistically, cytoplasmic circGLIS2 functions as a ceRNA by sponging miR-671, thereby activating NF-kappaB signaling (p65 phosphorylation/nuclear localization) and enhancing pro-inflammatory chemokine production with leukocyte recruitment."	0.8304
32974140	Frontiers in oncology	2020	Upregulated hsa_circ_0005785 Facilitates Cell Growth and Metastasis of Hepatocellular Carcinoma Through the miR-578/APRIL Axis.	hsa_circ_0005785				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"In hepatocellular carcinoma, hsa_circ_0005785 is up-regulated and promotes malignant phenotypes (proliferation, migration/invasion/metastasis) while inhibiting apoptosis and relieving cell-cycle arrest. Mechanistically, it functions as a cytoplasmic ceRNA sponging miR-578 to derepress the miR-578 target APRIL, thereby driving tumor progression and associating with poor overall survival."	0.8712
32977365	Journal of cellular and molecular medicine	2020	Knockdown of circ_0060745 alleviates acute myocardial infarction by suppressing NF-kappaB activation.	mmu_circ_0060745	circ_0060745			acute myocardial infarction 	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR	"In an LAD ligation mouse AMI model, circ_0060745 is up-regulated in infarcted myocardium and is enriched in cardiac fibroblasts. Silencing circ_0060745 reduces infarct size, improves systolic function, suppresses inflammatory cytokines and macrophage migration, and decreases cardiomyocyte apoptosis, at least partly by inhibiting NF-kappaB activation under hypoxia."	0.4236
32978168	Cancer research	2020	A Circle RNA Regulatory Axis Promotes Lung Squamous Metastasis via CDR1-Mediated Regulation of Golgi Trafficking.		CDR1as 	hsa_circ_CDR1	CDR1	Lung squamous carcinoma 	MONDO:0005097	squamous cell lung carcinoma	up-regulated	RT-qPCR; ISH	"CDR1as is up-regulated in LUSC tumors and is associated with worse patient survival. Functionally, the CDR1as/CDR1 axis promotes LUSC migration and metastasis in vivo, and therapeutic delivery of miR-671_5p inhibits metastasis by silencing CDR1as and CDR1 (largely in a miR-7-independent manner in this context)."	0.6956
32979257	Aging	2020	circKIF4A sponges miR-127 to promote ovarian cancer progression.		circKIF4A	hsa_circ_KIF4A	KIF4A	ovarian cancer	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circKIF4A is up-regulated in ovarian cancer tissues and promotes malignant phenotypes (proliferation, invasion/migration, tumor growth and lung metastasis). Mechanistically, it mainly localizes in the cytoplasm and acts as a ceRNA to sponge miR-127, thereby increasing JAM3 expression via an Ago2/RISC-associated interaction."	0.7759
32982273	OncoTargets and therapy	2019	Circular RNA PVT1 promotes the invasion and epithelial-mesenchymal transition of breast cancer cells through serving as a competing endogenous RNA for miR-204-5p.		circPVT1	hsa_circ_PVT1	PVT1	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circPVT1 is up-regulated in breast cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation, migration, invasion, EMT and tumor growth, at least partly by acting as a ceRNA that binds and suppresses miR-204-5p, and high circPVT1 is associated with worse overall survival."	0.6919
32982288	OncoTargets and therapy	2020	circKRT7-miR-29a-3p-COL1A1 Axis Promotes Ovarian Cancer Cell Progression.	hsa_circ_0026360	circKRT7 	hsa_circ_KRT7	KRT7	ovarian cancer	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circKRT7 is up-regulated in ovarian cancer tissues and promotes tumor cell proliferation, migration/invasion and in vivo xenograft growth. Mechanistically, it acts as a ceRNA by sponging miR-29a-3p to de-repress COL1A1, thereby enhancing EMT-related malignant progression."	0.8324
32982311	OncoTargets and therapy	2020	Circular RNA circNELL2 Acts as the Sponge of miR-127-5p to Promote Esophageal Squamous Cell Carcinoma Progression.	hsa_circ_0025933	circNELL2	hsa_circ_NELL2	NELL2	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"circNELL2 is up-regulated in ESCC and promotes malignant phenotypes (proliferation/colony formation/migration and xenograft growth). It acts as a ceRNA by sponging miR-127-5p, thereby increasing CDC6 expression and facilitating ESCC progression."	0.8521
32982348	"Diabetes, metabolic syndrome and obesity : targets and therapy"	2020	Interference of Hsa_circ_0003928 Alleviates High Glucose-Induced Cell Apoptosis and Inflammation in HK-2 Cells via miR-151-3p/Anxa2.	hsa_circ_0003928				diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"In diabetic nephropathy (patient serum and HG-induced HK-2 cells), hsa_circ_0003928 is up-regulated and aggravates high glucose-induced apoptosis and inflammatory injury. Mechanistically, hsa_circ_0003928 sponges miR-151-3p to regulate Anxa2, and knockdown of hsa_circ_0003928 alleviates ROS, cytokine production, and apoptosis."	0.6536
32982406	Cancer management and research	2020	"CircFLNA Acts as a Sponge of miR-646 to Facilitate the Proliferation, Metastasis, Glycolysis, and Apoptosis Inhibition of Gastric Cancer by Targeting PFKFB2."		circFLNA 	hsa_circ_FLNA	FLNA	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circFLNA is up-regulated in gastric cancer and promotes malignant phenotypes (proliferation, migration/invasion, glycolysis) while inhibiting apoptosis. Mechanistically, it functions as a ceRNA by sponging miR-646 to increase PFKFB2, thereby facilitating GC progression and tumor growth in vivo."	0.7548
32982415	Cancer management and research	2020	CircTTBK2 Contributes to the Progression of Glioma Through Regulating miR-145-5p/CPEB4 Axis.		circTTBK2	hsa_circ_TTBK2	TTBK2	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circTTBK2 is up-regulated in glioma and associated with poorer patient survival. Functionally, circTTBK2 promotes proliferation, migration/invasion, glycolysis and in vivo tumor growth while inhibiting apoptosis, mainly by sponging miR-145-5p to increase CPEB4 expression."	0.8295
32982419	Cancer management and research	2020	Circular RNA hsa_circ_0003496 Contributes to Tumorigenesis and Chemoresistance in Osteosarcoma Through Targeting (microRNA) miR-370/Kr¨¹ppel-Like Factor 12 Axis.	hsa_circ_0003496	circ_0003496			Osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"hsa_circ_0003496 (circ_0003496) is up-regulated in doxorubicin-chemoresistant osteosarcoma tissues and DXR-resistant OS cell lines. Functionally, it promotes proliferation/migration/invasion, inhibits apoptosis, increases MDR-related proteins, and enhances DXR resistance. Mechanistically, it acts as a miR-370 sponge to de-repress KLF12 (circ_0003496/miR-370/KLF12 axis)."	0.7289
32982424	Cancer management and research	2020	CircRNA Circ_0001721 Promotes the Progression of Osteosarcoma Through miR-372-3p/MAPK7 Axis.	hsa_circ_0001721	circ_0001721			Osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ_0001721 is upregulated in osteosarcoma and primarily localized in the cytoplasm. It promotes glycolysis, proliferation, migration, invasion and EMT while inhibiting apoptosis by sponging miR-372-3p to increase MAPK7 expression, and its high expression is associated with worse overall survival."	0.7588
32982440	Cancer management and research	2020	Circ_0007031 Serves as a Sponge of miR-760 to Regulate the Growth and Chemoradiotherapy Resistance of Colorectal Cancer via Regulating DCP1A.	hsa_circ_0007031	circ_0007031	hsa_circ_TUBGCP3	TUBGCP3	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0007031 is up-regulated in colorectal cancer, enriched in the cytoplasm, and promotes proliferation and chemoradiotherapy resistance. Mechanistically, it sponges miR-760 to increase DCP1A expression, thereby enhancing 5-Fu and radiation resistance; silencing circ_0007031 increases treatment sensitivity in vitro and in xenograft tumors."	0.7635
32982457	Cancer management and research	2020	Downregulation of circRNA_0000285 Suppresses Cervical Cancer Development by Regulating miR197-3p-ELK1 Axis.	hsa_circ_0000285	circ_0000285 	hsa_circ_HIPK3	HIPK3	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"hsa_circ_0000285 (circ_0000285), derived from HIPK3, is up-regulated in cervical cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes cervical cancer progression by acting as a ceRNA that sponges miR197-3p, thereby relieving repression of ELK1 and enhancing malignant phenotypes; its knockdown suppresses xenograft tumor growth."	0.7981
32984037	Frontiers in oncology	2020	Hsa_circ_0012152 and Hsa_circ_0001857 Accurately Discriminate Acute Lymphoblastic Leukemia From Acute Myeloid Leukemia.	hsa_circ_0012152				acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; Microarray	hsa_circ_0012152 is markedly up-regulated in AML (vs ALL and healthy controls) and serves as a classification/diagnostic biomarker to distinguish AML from ALL. Bioinformatics-based ceRNA analysis suggests it may sponge miR-491-5p or miR-512-3p to influence EGFR/MAPK1 and MAPK-related signaling in AML.	0.5963
32984037	Frontiers in oncology	2020	Hsa_circ_0012152 and Hsa_circ_0001857 Accurately Discriminate Acute Lymphoblastic Leukemia From Acute Myeloid Leukemia.	hsa_circ_0001857				acute lymphoblastic leukemia 	MONDO:0004967	acute lymphoblastic leukemia	up-regulated	RT-qPCR; Microarray	hsa_circ_0001857 is markedly up-regulated in ALL (vs AML and healthy controls) and serves as a classification biomarker to discriminate ALL from AML; this study did not further investigate its downstream mechanism.	0.5662
32984325	Frontiers in cell and developmental biology	2020	"Circular RNA circ-0016068 Promotes the Growth, Migration, and Invasion of Prostate Cancer Cells by Regulating the miR-330-3p/BMI-1 Axis as a Competing Endogenous RNA."	hsa_circ_0016068	circ-0016068	hsa_circ_BTG2	BTG2	prostate cancer	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	"circ-0016068 is up-regulated in prostate cancer tissues and cell lines and functions as an oncogenic circRNA. It mainly localizes to the cytoplasm and promotes proliferation, migration, invasion, EMT, and xenograft tumor growth/metastasis by sponging miR-330-3p to de-repress BMI-1."	0.8427
32993417	The Journal of international medical research	2020	Hsa_circ_0003829 serves as a potential diagnostic predictor for oral squamous cell carcinoma.	hsa_circ_0003829		hsa_circ_CASC4	CASC4	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR	"hsa_circ_0003829 is significantly down-regulated in OSCC tissues and OSCC cell lines and shows diagnostic potential (AUC 0.81). Bioinformatic prediction suggests it may act as a ceRNA by binding eight candidate miRNAs, though this mechanism is not experimentally validated in the study."	0.459
32993655	World journal of surgical oncology	2020	Hsa_circ_0000231 knockdown inhibits the glycolysis and progression of colorectal cancer cells by regulating miR-502-5p/MYO6 axis.	hsa_circ_0000231				colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"hsa_circ_0000231 is up-regulated in colorectal cancer and its high expression is associated with poorer survival. It promotes CRC cell proliferation, migration/invasion and glycolysis and inhibits apoptosis by sponging miR-502-5p to upregulate MYO6; knockdown suppresses tumor growth in a xenograft model."	0.7857
32999631	Cancer cell international	2020	Circ_002117 binds to microRNA-370 and promotes endoplasmic reticulum stress-induced apoptosis in gastric cancer.	hsa_circ_002117	circ_002117 			gastric cancer	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"circ_002117 is down-regulated in gastric cancer tissues/cells and acts as a tumor suppressor by binding miR-370 and relieving repression of HERPUD1. Through the circ_002117/miR-370/HERPUD1 axis, it enhances ER stress-associated signaling and promotes apoptosis, thereby inhibiting gastric cancer proliferation and xenograft tumor growth."	0.8618
33000177	International journal of molecular medicine	2020	Silencing circRNA_001937 may inhibit cutaneous squamous cell carcinoma proliferation and induce apoptosis by preventing the sponging of the miRNA_597_3p/FOSL2 pathway.		circRNA_001937			cutaneous squamous cell carcinoma 	MONDO:0002529	skin squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circRNA_001937 is up-regulated in CSCC tissues and cell lines. It promotes malignant behaviors (proliferation and invasion) and suppresses apoptosis, at least in part by sponging miRNA-597-3p to increase FOSL2 expression, forming a circRNA_001937/miRNA-597-3p/FOSL2 axis. It may have diagnostic biomarker potential for CSCC."	0.6829
33000178	International journal of molecular medicine	2020	"circRNA RNF111 regulates the growth, migration and invasion of gastric cancer cells by binding to miR_27b_3p."	hsa_circ_0001982	circRNA ring finger protein 111 (RNF111) 	hsa_circ_RNF111	RNF111	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"hsa_circ_0001982 (circR-RNF111) is up-regulated in gastric cancer tissues and cell lines and correlates with aggressive clinicopathological features. Functionally, circR-RNF111 promotes proliferation, migration and invasion while inhibiting apoptosis in GC cells, at least partly by sponging miR-27b-3p and modulating apoptosis- and EMT-related protein expression."	0.6542
33000244	Molecular medicine reports	2020	Expression and clinical significance of circular RNA hsa_circ_0079787 in the peripheral blood of patients with axial spondyloarthritis.	hsa_circ_0079787				axial spondyloarthritis 	MONDO:0005095	spondyloarthropathy	down-regulated	RT-qPCR	"hsa_circ_0079787 is down-regulated in peripheral blood of AxSpA patients and shows diagnostic value by ROC analysis, especially when combined with PLT/MPV/PCT. Its levels correlate with disease activity (BASDAI) and several blood parameters, and it has predicted miRNA-binding partners suggesting a potential miRNA-sponge role that remains unvalidated."	0.459
33000697	Technology in cancer research & treatment	2020	Comprehensive Characterization of Circular RNAs in Neuroblastoma Cell Lines.	hsa_circ_0005379				Neuroblastoma 	MONDO:0005072	neuroblastoma	dysregulated	RNA-seq	"In neuroblastoma cell lines, hsa_circ_0005379 was predicted to be a key ceRNA regulator, forming a complex network by competing for miRNAs and thereby linking to 13 downstream target genes."	0.1768
33000697	Technology in cancer research & treatment	2020	Comprehensive Characterization of Circular RNAs in Neuroblastoma Cell Lines.	hsa_circ_0002343				Neuroblastoma 	MONDO:0005072	neuroblastoma	dysregulated	RNA-seq	"In neuroblastoma cell lines, hsa_circ_0002343 was predicted (via ceRNA analysis) to influence the PI3K/Akt/mTOR signaling pathway through RAC1."	0.1768
33000697	Technology in cancer research & treatment	2020	Comprehensive Characterization of Circular RNAs in Neuroblastoma Cell Lines.	hsa_circ_0001361				Neuroblastoma 	MONDO:0005072	neuroblastoma	dysregulated	RNA-seq	"In neuroblastoma cell lines, hsa_circ_0001361 was predicted to be linked to EMT, connecting with EMT-related genes (NOTCH2, SERPINH1, LAMC1) in the constructed ceRNA framework."	0.1768
33000910	Thoracic cancer	2020	Hsa_circRNA_0000518 facilitates breast cancer development via regulation of the miR-326/FGFR1 axis.	hsa_circ_0000518	hsa_circRNA_0000518 	hsa_circ_RPPH1	RPPH1	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circ_0000518 is up-regulated in breast cancer tissues and cells and promotes malignant phenotypes (proliferation, colony formation, cell-cycle progression, migration/invasion) while inhibiting apoptosis. Mechanistically, it functions as a ceRNA that sponges miR-326 to increase FGFR1 expression, thereby promoting tumor growth in a cell line-derived xenograft model."	0.7302
33002329	Journal of cellular and molecular medicine	2020	CircHivep2 contributes to microglia activation and inflammation via miR-181a-5p/SOCS2 signalling in mice with kainic acid-induced epileptic seizures.	mmu_circ_0000146	circRNA_0000146 	mmu_circ_Hivep2	Hivep2	epilepsy 	MONDO:0005027	epilepsy	down-regulated	RT-qPCR; ISH; Microarray	"In a mouse kainic acid-induced epilepsy/status epilepticus model, circHivep2 (mmu_circ_0000146, derived from Hivep2) is down-regulated in hippocampus and KA-treated BV-2 microglia. Functionally, circHivep2 suppresses microglial activation and pro-inflammatory cytokine production by binding miR-181a-5p and relieving repression of SOCS2, and it can also interact with TDP-43 to impair miR-181a-5p biogenesis. Delivery of circHivep2-overexpressing ADSC exosomes improves seizure behavioral scores and dampens neuroinflammation in vivo."	0.7296
33005174	Frontiers in genetics	2020	Exosomal Circ-MEMO1 Promotes the Progression and Aerobic Glycolysis of Non-small Cell Lung Cancer Through Targeting MiR-101-3p/KRAS Axis.		circ-MEMO1 	hsa_circ_MEMO1	MEMO1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ-MEMO1 is up-regulated in NSCLC tissues and serum exosomes and functions as an oncogenic circRNA. It mainly localizes to the cytoplasm and promotes NSCLC cell proliferation, cell-cycle progression, and aerobic glycolysis while inhibiting apoptosis, largely via the circ-MEMO1/miR-101-3p/KRAS ceRNA axis. High circ-MEMO1 correlates with poor survival and exosomal circ-MEMO1 shows diagnostic potential by ROC analysis."	0.8709
33005182	Frontiers in genetics	2020	Circular RNA CircHIPK3 Elevates CCND2 Expression and Promotes Cell Proliferation and Invasion Through miR-124 in Glioma.		circHIPK3 	hsa_circ_HIPK3	HIPK3	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in glioma tissues/cell lines and promotes glioma cell proliferation, migration, and invasion. Mechanistically, it acts as a ceRNA by sponging miR-124, thereby elevating CCND2 expression."	0.5416
33006960	Medical science monitor : international medical journal of experimental and clinical research	2020	Circular RNA circ_C16orf62 Suppresses Cell Growth in Gastric Cancer by miR-421/Tubulin beta-2A Chain (TUBB2A) Axis.	hsa_circ_0005699	circ_C16orf62	hsa_circ_C16orf62	C16orf62	Gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"circ_C16orf62 is down-regulated in gastric cancer tissues and cell lines and mainly localizes to the cytoplasm. It suppresses GC cell proliferation, migration and invasion and inhibits xenograft tumor growth by sponging miR-421 to increase TUBB2A expression."	0.7223
33012723	Aging	2020	Comprehensive analysis of TGF-beta-induced mRNAs and ncRNAs in hepatocellular carcinoma.	hsa_circ_0006123				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0006123 is up-regulated in HCC tissues and further increased in patients with vascular invasion. Functional knockdown assays indicate it promotes EMT-associated migration and invasion in HCC cell lines, and it is proposed to act via a predicted circRNA_miRNA_mRNA ceRNA network under TGF-beta-induced EMT conditions."	0.5923
33012723	Aging	2020	Comprehensive analysis of TGF-beta-induced mRNAs and ncRNAs in hepatocellular carcinoma.	hsa_circ_0005480				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	hsa_circ_0005480 is experimentally validated by RT-qPCR to be up-regulated in HCC tissues compared with adjacent non-cancerous tissues; no further functional or mechanistic validation is reported for this circRNA in the study.	0.2995
33015172	BioMed research international	2020	circHIPK3 Acts as Competing Endogenous RNA and Promotes Non-Small-Cell Lung Cancer Progression through the miR-107/BDNF Signaling Pathway.		circHIPK3 	hsa_circ_HIPK3	HIPK3	non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in NSCLC cells and promotes proliferation, migration, and invasion. Mechanistically, it sponges miR-107 to relieve repression of the downstream target BDNF, forming a circHIPK3/miR-107/BDNF ceRNA axis with potential biomarker relevance in NSCLC."	0.5416
33024586	Journal of gastric cancer	2020	Circular RNA hsa_circ_0005556 Accelerates Gastric Cancer Progression by Sponging miR-4270 to Increase MMP19 Expression.	hsa_circ_0005556	circ_0005556	hsa_circ_NBAS	NBAS	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"hsa_circ_0005556 is up-regulated in gastric cancer tissues and cell lines and promotes proliferation, migration, invasion and tumor growth. Mechanistically, it functions as a ceRNA by sponging miR-4270, thereby increasing MMP19 expression and contributing to EMT-related changes."	0.6544
33028110	Cell transplantation	2020	circRNA hsa_circ_104566 Sponged miR-338-3p to Promote Hepatocellular Carcinoma Progression.		hsa_circ_104566 	hsa_circ_PSD3	PSD3	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"hsa_circ_104566 is up-regulated in HCC and its high expression is associated with shorter overall survival. Functionally, it promotes proliferation, migration, invasion and EMT-like changes and inhibits apoptosis by acting as a ceRNA that sponges miR-338-3p to increase FOXP1, and its knockdown suppresses tumor growth and metastasis in xenograft models."	0.8156
33028742	Aging	2020	Circ-0001068 is a novel biomarker for ovarian cancer and inducer of PD1 expression in T cells.	hsa_circ_0001068	Circ-0001068	hsa_circ_MGAT5	MGAT5	ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; Microarray	"circ-0001068 is up-regulated in serum exosomes and tumor tissues from ovarian cancer patients and shows strong diagnostic performance by ROC analysis. OC-derived exosomal circ-0001068 can enter T cells and function as a ceRNA that sponges miR-28-5p, thereby relieving repression of PD1 and promoting PD1 upregulation associated with T cell exhaustion/immune evasion."	0.7039
33028811	Cell death & disease	2020	CircRNA_09505 aggravates inflammation and joint damage in collagen-induced arthritis mice via miR-6089/AKT1/NF-kappaB axis.		circRNA_09505			rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; RNA-seq	"circRNA_09505 is up-regulated in RA PBMCs/monocytes and mainly localizes to the cytoplasm of macrophages. It promotes macrophage proliferation, cell-cycle progression, and inflammatory cytokine production by sponging miR-6089 to increase AKT1 and activate IkappaBalpha/NF-kappaB signaling; its knockdown alleviates inflammation and joint damage in CIA mice."	0.7229
33029498	BioMed research international	2020	"circSMARCA5 Promoted Osteosarcoma Cell Proliferation, Adhesion, Migration, and Invasion through a Competing Endogenous RNA Network."	hsa_circ_0001445	circSMARCA5	hsa_circ_SMARCA5	SMARCA5	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circSMARCA5 (hsa_circ_0001445) is up-regulated in osteosarcoma cells and functions as an oncogenic circRNA, promoting proliferation, adhesion, migration, and invasion. Mechanistically, the study proposes a CircNet-predicted ceRNA network in which circSMARCA5 sponges multiple miRNAs (e.g., miR-432-5p and miR-181c-3p) and connects to a set of downstream mRNAs, but the miRNA/mRNA interactions were not experimentally validated here."	0.4546
33030101	Technology in cancer research & treatment	2020	Downregulation of circRNA_100876 Inhibited Progression of NSCLC In Vitro via Targeting miR-636.		circRNA_100876 			non-small cell lung carcinoma 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"In NSCLC cell lines, circRNA_100876 promotes malignant phenotypes (proliferation, migration/invasion) and suppresses apoptosis. Mechanistically it sponges miR-636 to de-repress RET and activate PI3K/Akt signaling (with reduced p-Akt and p-ERK upon knockdown)."	0.5627
33033491	Frontiers in genetics	2020	CircDENND2A Promotes Non-small Cell Lung Cancer Progression via Regulating MiR-34a/CCNE1 Signaling.		circDENND2A	hsa_circ_DENND2A	DENND2A	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circDENND2A is up-regulated in NSCLC tissues and promotes malignant phenotypes (proliferation/viability, migration, invasion) while suppressing apoptosis and G0/G1 arrest. Mechanistically, it functions as a ceRNA that sponges miR-34a to increase CCNE1 expression, and CCNE1 restoration rescues the effects of circDENND2A knockdown."	0.6536
33041662	Cancer cell international	2020	"Circ_0000285 regulates proliferation, migration, invasion and apoptosis of osteosarcoma by miR-409-3p/IGFBP3 axis."	hsa_circ_0000285	circ_0000285	hsa_circ_HIPK3	HIPK3	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ_0000285 is up-regulated in osteosarcoma tissues and cell lines and mainly localizes to the cytoplasm. It promotes osteosarcoma cell proliferation, migration and invasion while inhibiting apoptosis by sponging miR-409-3p to upregulate IGFBP3, and its knockdown suppresses tumor growth in a xenograft model."	0.7984
33041665	Cancer cell international	2020	The novel circ_0028171/miR-218-5p/IKBKB axis promotes osteosarcoma cancer progression.	hsa_circ_0028171	circ_0028171 	hsa_circ_ATP2A2	ATP2A2	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"circ_0028171 is up-regulated in osteosarcoma tissues and cell lines and mainly localizes to the cytoplasm. It promotes osteosarcoma proliferation, migration, invasion and in vivo tumor growth by sponging miR-218-5p, thereby increasing IKBKB expression."	0.8228
33042261	Theranostics	2020	Circular RNA circPPM1F modulates M1 macrophage activation and pancreatic islet inflammation in type 1 diabetes mellitus.	hsa_circ_0062444	circPPM1F	hsa_circ_PPM1F	PPM1F	type 1 diabetes mellitus 	MONDO:0005147	type 1 diabetes mellitus	up-regulated	RT-qPCR; Microarray	"circPPM1F is up-regulated in PBMCs from children with T1DM (mainly in monocytes) and promotes LPS-induced M1 macrophage activation. It enhances NF-kappaB signaling by competitively binding HuR to suppress translation of its host gene PPM1F, thereby aggravating pancreatic islet inflammation/injury in an STZ-induced diabetic mouse model."	0.8611
33043809	Technology in cancer research & treatment	2020	Identification of Hsa_circ_0104824 as a Potential Biomarkers for Breast Cancer.	hsa_circ_0104824		hsa_circ_NTRK3	NTRK3	Breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0104824 (host gene NTRK3) is significantly downregulated in breast cancer tissues and in patient peripheral blood. It shows good diagnostic performance by ROC analysis and is proposed to act as an miRNA sponge based on bioinformatic predictions, with inferred links to metastasis- and proliferation-related processes."	0.5047
33047994	Cancer biology & therapy	2020	"Circular RNA hsa_circ_0003204 promotes cervical cancer cell proliferation, migration, and invasion by regulating MAPK pathway."	hsa_circ_0003204				Cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0003204 is up-regulated in cervical cancer tissues/cell lines and functions as an oncogenic circRNA. Its knockdown suppresses proliferation, migration and invasion and increases apoptosis, while overexpression has the opposite effects and enhances xenograft tumor growth, associated with activation of MAPK signaling (increased p-ERK and p-P38)."	0.7523
33049714	Aging	2020	CircPDZD8 promotes gastric cancer progression by regulating CHD9 via sponging miR-197-5p.	hsa_circ_0020123	circPDZD8	hsa_circ_PDZD8	PDZD8	gastric cancer	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circPDZD8 is up-regulated in gastric cancer and mainly localized in the cytoplasm. It promotes gastric cancer cell proliferation and migration and tumor growth by acting as a ceRNA that sponges miR-197-5p, thereby increasing CHD9 expression via the miR-197-5p/CHD9 axis. High circPDZD8 expression is associated with poorer overall survival."	0.7369
33052880	Aging	2020	CircRNA CDR1as promotes hepatoblastoma proliferation and stemness by acting as a miR-7-5p sponge to upregulate KLF4 expression.	hsa_circ_0001946	CDR1as	hsa_circ_CDR1	CDR1	hepatoblastoma 	MONDO:0018666	hepatoblastoma	up-regulated	RT-qPCR	"CDR1as is up-regulated in hepatoblastoma tissues/cell lines and in CSC-enriched spheres. Functionally, CDR1as promotes HB cell proliferation and cancer stemness by acting as a ceRNA that sponges miR-7-5p, thereby increasing KLF4 expression; CDR1as knockdown suppresses tumor growth in a HepG2 xenograft model."	0.8634
33060778	Scientific reports	2020	"Cir-ITCH inhibits gastric cancer migration, invasion and proliferation by regulating the Wnt/beta-catenin pathway."		cir-ITCH 	hsa_circ_ITCH	ITCH	gastric cancer	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"cir-ITCH is down-regulated in gastric cancer and functions as a tumor suppressor by inhibiting proliferation, migration, invasion and in vivo tumor growth. Mechanistically, cir-ITCH sponges miR-17 (also binds miR-214), elevates linear ITCH, and suppresses canonical Wnt/beta-catenin signaling (Dvl2/beta-catenin and Wnt target genes such as c-Myc and cyclin D1). High cir-ITCH expression is associated with better overall survival."	0.859
33061423	OncoTargets and therapy	2020	Circular RNA Hsa_circ_0004018 Inhibits Wnt/beta-Catenin Signaling Pathway by Targeting microRNA-626/DKK3 in Hepatocellular Carcinoma.	hsa_circ_0004018				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"hsa_circ_0004018 is down-regulated in HCC tissues and cell lines and suppresses HCC proliferation/migration and xenograft growth. Mechanistically, it sponges miR-626 to relieve repression of DKK3, thereby inhibiting Wnt/beta-catenin signaling (reduced beta-catenin/TCF activity and c-myc)."	0.7052
33061425	OncoTargets and therapy	2020	Paclitaxel Suppresses Hepatocellular Carcinoma Tumorigenesis Through Regulating Circ-BIRC6/miR-877-5p/YWHAZ Axis.	hsa_circ_0003288	circ-BIRC6	hsa_circ_BIRC6	BIRC6	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ-BIRC6 is upregulated in HCC tissues/cells and promotes tumorigenesis by sponging miR-877-5p to increase YWHAZ expression. Paclitaxel suppresses HCC partly by downregulating circ-BIRC6, thereby relieving miR-877-5p suppression and reducing YWHAZ."	0.6536
33061434	OncoTargets and therapy	2020	Circ_0006528 Contributes to Paclitaxel Resistance of Breast Cancer Cells by Regulating miR-1299/CDK8 Axis.	hsa_circ_0006528	circ_0006528			breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0006528 is up-regulated in paclitaxel-resistant breast cancer tissues and cells and promotes PTX resistance and malignant behaviors. Mechanistically, it sponges miR-1299 to upregulate CDK8, thereby enhancing proliferation/migration/invasion and autophagy while suppressing apoptosis, and it promotes tumor growth in xenograft models."	0.7591
33061591	Cancer management and research	2020	CircRNA CDR1as/miR-1287/Raf1 Axis Modulates Hepatocellular Carcinoma Progression Through MEK/ERK Pathway.	hsa_circ_0001946	circ_CDR1as 	hsa_circ_CDR1		hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_CDR1as is up-regulated in HCC tissues and cell lines and promotes proliferation, migration/invasion, EMT and xenograft tumor growth. Mechanistically, it sponges miR-1287 to increase Raf1 expression and thereby activates the MEK/ERK pathway."	0.7631
33061603	Cancer management and research	2020	The Hsa_circ_0091579/miR-940/TACR1 Axis Regulates the Development of Hepatocellular Carcinoma.	hsa_circ_0091579	circ_0091579	hsa_circ_GPC3	GPC3	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"hsa_circ_0091579 (circ_0091579) is up-regulated in HCC tissues and cell lines and functions as an oncogenic circRNA. Its knockdown suppresses proliferation/colony formation, migration/invasion, induces G0/G1 arrest and apoptosis, and reduces xenograft tumor growth by acting as a ceRNA that sponges miR-940 to upregulate TACR1."	0.7421
33061606	Cancer management and research	2020	"Knockdown of circPRKCA Restrained Cell Growth, Migration, and Invasion of NSCLC Cells Both in vitro and in vivo via Regulating miR-330-5p/PDK1/AKT Pathway."	hsa_circ_0007580	circPRKCA_024 	hsa_circ_PRKCA	PRKCA	non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circPRKCA is up-regulated in NSCLC tissues and cell lines and acts oncogenically. It sponges miR-330-5p to increase PDK1 expression and activate AKT signaling, thereby promoting proliferation/viability, migration and invasion and inhibiting apoptosis; circPRKCA knockdown suppresses xenograft tumor growth."	0.7289
33061608	Cancer management and research	2020	Downregulation of circNRIP1 Suppresses the Paclitaxel Resistance of Ovarian Cancer via Regulating the miR-211-5p/HOXC8 Axis.	hsa_circ_0002711	circNRIP1 	hsa_circ_NRIP1	NRIP1	ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circNRIP1 is up-regulated in paclitaxel-resistant ovarian cancer tissues and cells. circNRIP1 promotes paclitaxel resistance and malignant phenotypes by acting as a cytoplasmic ceRNA that sponges miR-211-5p, thereby increasing HOXC8 expression; circNRIP1 knockdown sensitizes tumors to paclitaxel in a xenograft model."	0.7983
33061613	Cancer management and research	2020	Gambogic Acid Inhibits the Progression of Gastric Cancer via circRNA_ASAP2/miR-33a-5p/CDK7 Axis.		circ_ASAP2 	hsa_circ_ASAP2	ASAP2	Gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_ASAP2 is up-regulated in gastric cancer tissues and cells. It promotes GC cell proliferation, migration and invasion and inhibits apoptosis by sponging miR-33a-5p to upregulate CDK7, thereby weakening the anti-tumor effects of gambogic acid."	0.7595
33061617	Cancer management and research	2020	Circ_0084927 Facilitates Cervical Cancer Development via Sponging miR-142-3p and Upregulating ARL2.	hsa_circ_0084927	circ_0084927			cervical cancer	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ_0084927 is up-regulated in cervical cancer tissues/cells and promotes malignant phenotypes (proliferation, cell-cycle progression, migration/invasion) and xenograft tumor growth. Mechanistically, it acts as a ceRNA to sponge miR-142-3p, thereby de-repressing/upregulating ARL2."	0.8001
33061621	Cancer management and research	2020	Up-Regulation of circRNA hsa_circ_0003074 Expression is a Reliable Diagnostic and Prognostic Biomarker in Patients with Osteosarcoma.	hsa_circ_0003074				osteosarcoma	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0003074 is up-regulated in osteosarcoma tissues and blood and is elevated in osteosarcoma cell lines. High hsa_circ_0003074 supports osteosarcoma diagnosis (AUC 0.93) and predicts worse prognosis with reduced OS and PFS; its level is associated with tumor size, lung metastasis, relapse, and chemotherapy resistance."	0.5416
33061624	Cancer management and research	2020	CircCFL1/MiR-107 Axis Targeting HMGB1 Promotes the Malignant Progression of Diffuse Large B-Cell Lymphoma Tumors.		CircCFL1		CFL1	diffuse large B-cell lymphoma 	MONDO:0018905	diffuse large B-cell lymphoma	unknown	RT-qPCR	"CircCFL1 promotes DLBCL malignant behaviors (proliferation, migration/invasion and xenograft tumor growth) by sponging miR-107 and de-repressing HMGB1. This is associated with increased phosphorylation of AKT, ERK and STAT3."	0.6323
33061631	Cancer management and research	2020	Hsa_circ_0084927 Regulates Cervical Cancer Advancement via Regulation of the miR-634/TPD52 Axis.	hsa_circ_0084927		hsa_circ_ESRP1	ESRP1	Cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"hsa_circ_0084927 is up-regulated in cervical cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes malignant phenotypes and tumor growth by sponging miR-634, thereby upregulating the target gene TPD52 (circRNA/miRNA/mRNA axis). High hsa_circ_0084927 expression correlates with adverse clinicopathologic features and poorer survival."	0.8006
33061633	Cancer management and research	2020	Circ_0058124 Aggravates the Progression of Papillary Thyroid Carcinoma by Activating LMO4 Expression via Targeting miR-370-3p.	hsa_circ_0058124	circ_0058124	hsa_circ_FN1	FN1	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circ_0058124 is up-regulated in papillary thyroid carcinoma tissues and cell lines and acts as an oncogenic circRNA. It promotes PTC cell proliferation, migration and invasion and suppresses apoptosis by sponging miR-370-3p to increase LMO4 expression (circ_0058124/miR-370-3p/LMO4 axis), and its knockdown inhibits xenograft tumor growth."	0.795
33061642	Cancer management and research	2020	CircCSNK1G1 Contributes to the Development of Colorectal Cancer by Increasing the Expression of MYO6 via Competitively Targeting miR-455-3p.	hsa_circ_0001955	circCSNK1G1 	hsa_circ_CSNK1G1	CSNK1G1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circCSNK1G1 is up-regulated in colorectal cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes malignant phenotypes and xenograft tumor growth by sponging miR-455-3p, thereby increasing MYO6 expression (circCSNK1G1/miR-455-3p/MYO6 axis)."	0.8207
33061643	Cancer management and research	2020	CircNFIX Acts as a miR-212-3p Sponge to Enhance the Malignant Progression of Non-Small Cell Lung Cancer by Up-Regulating ADAM10.	hsa_circ_0049658	circNFIX	hsa_circ_NFIX		non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circNFIX is up-regulated in NSCLC tissues/cells and high circNFIX is associated with worse overall survival. Functionally, circNFIX promotes NSCLC proliferation/viability, migration, invasion, glycolysis and in vivo tumor growth by sponging miR-212-3p to de-repress ADAM10."	0.7353
33061846	Cancer cell international	2020	Hsa_circ_0026416 promotes proliferation and migration in colorectal cancer via miR-346/NFIB axis.	hsa_circ_0026416	circ_0026416	hsa_circ_KRT6C	KRT6C	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0026416 is up-regulated in colorectal cancer tissues and plasma and primarily localizes to the cytoplasm. It promotes CRC proliferation, migration and invasion (and tumor growth in xenografts) by sponging miR-346, thereby increasing NFIB expression, and its high expression is associated with poorer overall survival and diagnostic value."	0.8094
33061972	Journal of oncology	2020	Bioinformatics-Based Identification of a circRNA-miRNA-mRNA Axis in Esophageal Squamous Cell Carcinomas.	hsa_circ_0052867	circ_0052867			Esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	Microarray	"circ_0052867 was identified by intersecting predicted miR-139-5p_targeting circRNAs with differentially expressed circRNAs in ESCC microarray data. The study proposes a circ_0052867/miR-139-5p/RAP1B ceRNA axis that may relate to ESCC progression and patient survival, but lacks experimental validation."	0.1768
33061973	Journal of oncology	2020	"Circ_0072088 Promotes Proliferation, Migration, and Invasion of Esophageal Squamous Cell Cancer by Absorbing miR-377."	hsa_circ_0072088	circ_0072088	hsa_circ_ZFR	ZFR	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0072088 is upregulated in ESCC and promotes proliferation, migration, and invasion. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-377, thereby increasing VEGF expression and enhancing malignant phenotypes, including tumor growth in a xenograft model."	0.8558
33062700	BioMed research international	2020	Identification of Circular RNA-MicroRNA-Messenger RNA Regulatory Network in Atrial Fibrillation by Integrated Analysis.		hsa_circRNA_100053 	hsa_circ_MFN2	MFN2	atrial fibrillation 	MONDO:0004981	atrial fibrillation	down-regulated	Microarray	"hsa_circRNA_100053 (host gene MFN2) is down-regulated in AF heart tissue and was proposed to participate in AF through a ceRNA relationship with hsa-miR-455-5p affecting TRPV1 expression, potentially linking to cardioprotective responses."	0.1768
33062700	BioMed research international	2020	Identification of Circular RNA-MicroRNA-Messenger RNA Regulatory Network in Atrial Fibrillation by Integrated Analysis.		hsa_circRNA_005843 			atrial fibrillation 	MONDO:0004981	atrial fibrillation	down-regulated	Microarray	"hsa_circRNA_005843 is down-regulated in AF heart tissue and was proposed to be associated with AF through a ceRNA interaction with hsa-miR-188-5p affecting SPON1, with discussion linking the miRNA/mRNA to angiogenesis-related roles."	0.1768
33062700	BioMed research international	2020	Identification of Circular RNA-MicroRNA-Messenger RNA Regulatory Network in Atrial Fibrillation by Integrated Analysis.		hsa-circRNA-402565 			atrial fibrillation 	MONDO:0004981	atrial fibrillation	up-regulated	RT-qPCR; Microarray	"hsa-circRNA-402565 is up-regulated in AF and its differential expression was validated by qRT-PCR in blood samples, supporting an association with AF pathology, though no specific downstream mechanism was established in this paper."	0.4032
33063376	Journal of clinical laboratory analysis	2021	Research on the circular RNA bioinformatics in patients with acute myocardial infarction.	hsa_circ_0066439				acute myocardial infarction 	MONDO:0004781	acute myocardial infarction	down-regulated	Microarray	"hsa_circ_0066439 is down-regulated in AMI patient plasma/blood by microarray and is predicted (via circRNA_miRNA network analysis) to bind miRNAs such as hsa-miR-1254 and hsa-miR-328-5p, thereby potentially participating in AMI through multiple signaling pathways."	0.348
33063376	Journal of clinical laboratory analysis	2021	Research on the circular RNA bioinformatics in patients with acute myocardial infarction.	hsa_circ_0081241				acute myocardial infarction 	MONDO:0004781	acute myocardial infarction	up-regulated	Microarray	"hsa_circ_0081241 is up-regulated in AMI patient plasma/blood by microarray and is highlighted in a predicted circRNA_miRNA network as a circRNA that can bind miR-328-5p (and also mentioned with miRNAs including hsa-miR-1254), suggesting a potential role in AMI-related signaling regulation."	0.348
33063376	Journal of clinical laboratory analysis	2021	Research on the circular RNA bioinformatics in patients with acute myocardial infarction.	hsa_circ_0122984				acute myocardial infarction 	MONDO:0004781	acute myocardial infarction	down-regulated	Microarray	hsa_circ_0122984 is down-regulated in AMI patient plasma/blood by microarray and is identified in a predicted circRNA_miRNA network (including miRNAs such as hsa-miR-1254 and hsa-miR-328-5p) as potentially participating in AMI via regulation of multiple signaling pathways.	0.348
33063376	Journal of clinical laboratory analysis	2021	Research on the circular RNA bioinformatics in patients with acute myocardial infarction.	hsa_circ_0043563				acute myocardial infarction 	MONDO:0004781	acute myocardial infarction	up-regulated	Microarray	hsa_circ_0043563 is reported as an up-regulated novel circRNA candidate in AMI plasma based on microarray screening and is predicted to interact with miRNAs (including hsa-miR-4763-3p and hsa-miR-328-5p) in a circRNA_miRNA network that may regulate multiple signaling pathways relevant to AMI.	0.348
33063376	Journal of clinical laboratory analysis	2021	Research on the circular RNA bioinformatics in patients with acute myocardial infarction.	hsa_circ_0119137				acute myocardial infarction 	MONDO:0004781	acute myocardial infarction	up-regulated	Microarray	hsa_circ_0119137 is identified as an up-regulated novel circRNA candidate in AMI plasma and is predicted to interact with miRNAs (including hsa-miR-4763-3p and hsa-miR-328-5p) in a circRNA_miRNA network potentially involved in AMI-related signaling regulation.	0.348
33063376	Journal of clinical laboratory analysis	2021	Research on the circular RNA bioinformatics in patients with acute myocardial infarction.	hsa_circ_0025097				acute myocardial infarction 	MONDO:0004781	acute myocardial infarction	up-regulated	Microarray	"hsa_circ_0025097 is up-regulated in AMI plasma by microarray and is predicted to bind hsa-miR-328-5p in a circRNA_miRNA network, potentially influencing multiple signaling pathways involved in AMI."	0.348
33063376	Journal of clinical laboratory analysis	2021	Research on the circular RNA bioinformatics in patients with acute myocardial infarction.	hsa_circ_0106804				acute myocardial infarction 	MONDO:0004781	acute myocardial infarction	down-regulated	Microarray	hsa_circ_0106804 is reported as a down-regulated novel circRNA candidate in AMI plasma and is predicted to interact with miRNAs (including hsa-miR-4763-3p and hsa-miR-328-5p) in a circRNA_miRNA network potentially involved in AMI-related signaling regulation.	0.348
33063376	Journal of clinical laboratory analysis	2021	Research on the circular RNA bioinformatics in patients with acute myocardial infarction.	hsa_circ_0085214				acute myocardial infarction 	MONDO:0004781	acute myocardial infarction	down-regulated	Microarray	hsa_circ_0085214 is reported as a down-regulated novel circRNA candidate in AMI plasma and is predicted to interact with miRNAs (including hsa-miR-4763-3p and hsa-miR-328-5p) in a circRNA_miRNA network potentially involved in AMI-related signaling regulation.	0.348
33063376	Journal of clinical laboratory analysis	2021	Research on the circular RNA bioinformatics in patients with acute myocardial infarction.	hsa_circ_0028302				acute myocardial infarction 	MONDO:0004781	acute myocardial infarction	down-regulated	Microarray	"hsa_circ_0028302 is identified as a down-regulated novel circRNA candidate in AMI plasma and is predicted to bind hsa-miR-328-5p, potentially regulating multiple signaling pathways involved in AMI and suggested as a possible diagnostic/therapeutic target candidate."	0.348
33064661	Journal of molecular endocrinology	2020	Circ-Tulp4 promotes beta-cell adaptation to lipotoxicity by regulating soat1 expression.		circ-Tulp4	mmu_circ_Tulp4	TULP4	type 2 diabetes 	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RT-qPCR; RNA-seq	"circ-Tulp4 is down-regulated in islets of T2DM mouse models and in Min6 cells under palmitate-induced lipotoxicity. It promotes beta-cell proliferation and preserves insulin secretory function by sponging miR-7222-3p, thereby relieving repression of soat1 and increasing cyclin D1 to drive cell-cycle progression."	0.7564
33082297	Aging	2020	Hsa_circ_0081534 increases the proliferation and invasion of nasopharyngeal carcinoma cells through regulating the miR-508-5p/FN1 axis.	hsa_circ_0081534	circEPHB4 	hsa_circ_EPHB4	EPHB4	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0081534 is up-regulated in nasopharyngeal carcinoma tissues and cell lines and promotes NPC cell proliferation and invasion. Mechanistically, it mainly localizes in the cytoplasm and acts as a ceRNA by sponging miR-508-5p, thereby increasing FN1 expression; knockdown suppresses xenograft tumor growth."	0.822
33083467	BioMed research international	2020	Comprehensive Analysis of Differentially Expressed Circular RNAs in Patients with Senile Osteoporotic Vertebral Compression Fracture.	hsa_circ_0079449	circ_0079449			senile osteoporotic vertebral compression fracture 	MONDO:0005298	osteoporosis	dysregulated	RT-qPCR; RNA-seq	circ_0079449 is differentially expressed in peripheral blood of patients with senile OVCF versus controls and was validated by RT-qPCR. The study predicts a circ_0079449-centered circRNA_miRNA_mRNA network by bioinformatics.	0.4032
33083467	BioMed research international	2020	Comprehensive Analysis of Differentially Expressed Circular RNAs in Patients with Senile Osteoporotic Vertebral Compression Fracture.	hsa_circ_0122913	circ_0122913			senile osteoporotic vertebral compression fracture 	MONDO:0005298	osteoporosis	dysregulated	RT-qPCR; RNA-seq	circ_0122913 is differentially expressed in peripheral blood of patients with senile OVCF versus controls and was validated by RT-qPCR. The study predicts a circ_0122913-centered circRNA_miRNA_mRNA network by bioinformatics.	0.4032
33083473	BioMed research international	2020	The Regulation of circRNA RNF13/miRNA-1224-5p Axis Promotes the Malignant Evolution in Acute Myeloid Leukemia.		circRNF13 	hsa_circ_RNF13	RNF13	acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"circRNF13 is up-regulated in AML patient blood. Functional assays in AML cell lines indicate that circRNF13 promotes proliferation, cell-cycle progression, migration and invasion while suppressing apoptosis, and it directly interacts with miRNA-1224-5p."	0.6278
33085838	Molecular oncology	2021	CircRNA EPHB4 modulates stem properties and proliferation of gliomas via sponging miR-637 and up-regulating SOX10.	hsa_circ_0081519	circEPHB4 	hsa_circ_EPHB4	EPHB4	gliomas 	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circEPHB4 is up-regulated in gliomas and promotes glioma stemness, proliferation/cell-cycle progression, and glycolysis while inhibiting apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-637, thereby up-regulating SOX10 and its downstream target Nestin; high circEPHB4 is associated with poorer overall survival."	0.7794
33089764	Technology in cancer research & treatment	2020	Circ_0000215 Increases the Expression of CXCR2 and Promoted the Progression of Glioma Cells by Sponging miR-495-3p.	hsa_circ_0000215	Circ_0000215 			glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ_0000215 is upregulated in glioma tissues and cell lines and promotes glioma progression. It functions as a ceRNA that sponges miR-495-3p, thereby relieving repression of CXCR2 and enhancing downstream PI3K/Akt signaling, leading to increased proliferation, invasion and EMT and reduced apoptosis."	0.7537
33090705	Journal of cellular and molecular medicine	2020	"circ_SEPT9, a newly identified circular RNA, promotes oral squamous cell carcinoma progression through miR-1225/PKN2 axis."	hsa_circ_0005320	circ_SEPT9 	hsa_circ_SEPT9	SEPT9	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circ_SEPT9 is up-regulated in OSCC tissues and cell lines and promotes proliferation, tumour growth, migration and invasion. It functions as a miR-1225 sponge to relieve repression of PKN2, forming a circ_SEPT9/miR-1225/PKN2 ceRNA axis that drives OSCC progression."	0.8115
33093901	Experimental and therapeutic medicine	2020	Circular RNA expression profiles significantly altered in UVA-irradiated human dermal fibroblasts.	hsa_circ_0006766	circ-0006766		CCL24	photoaging 			down-regulated	RT-qPCR; Microarray	"circ-0006766 (hsa_circ_0006766) is significantly down-regulated in UVA-irradiated human dermal fibroblasts (a photoaging model), and this decrease was consistent between circRNA microarray profiling and RT-qPCR validation."	0.4032
33093901	Experimental and therapeutic medicine	2020	Circular RNA expression profiles significantly altered in UVA-irradiated human dermal fibroblasts.	hsa_circ_0011129	circ-0011129			photoaging 			down-regulated	RT-qPCR; Microarray	"circ-0011129 (hsa_circ_0011129) is significantly down-regulated in UVA-irradiated human dermal fibroblasts. Bioinformatic predictions suggest it may sponge hsa-miR-484, hsa-miR-3619-5p, and hsa-miR-6732-5p, potentially relating to collagen/elastin-associated targets in photoaging."	0.4032
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0008310		hsa_circ_CNTROB	CNTROB	Stomach Adenocarcinoma	MONDO:0005036	gastric adenocarcinoma	up-regulated	RT-qPCR; Microarray	"In pan-cancer, hsa_circ_0008310 is up-regulated and shows pro-malignant effects: its knockdown suppresses proliferation, migration, and invasion in cancer cell lines. The study predicts it may participate in a ceRNA network involving miR-3174 (and possibly miR-760) and downstream targets such as NUSAP1/NEK2/CENPI."	0.5008
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0004639		hsa_circ_NECTIN3	NECTIN3	Stomach Adenocarcinoma	MONDO:0005036	gastric adenocarcinoma	down-regulated	RT-qPCR; Microarray	"In pan-cancer, hsa_circ_0004639 is down-regulated and acts as a tumor-suppressive circRNA in functional assays: its overexpression inhibits proliferation, migration, and invasion. The study predicts it may be involved in a ceRNA network affecting miR-3174 (and also miR-507/miR-4517 responses) with potential downstream targets including NUSAP1/NEK2/CENPI."	0.5008
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0020390		hsa_circ_DOCK1	DOCK1	Stomach Adenocarcinoma	MONDO:0005036	gastric adenocarcinoma	down-regulated	Microarray	"hsa_circ_0020390 is identified as a down-regulated pan-circRNA in pan-cancer through integrated microarray screening and was included in predicted ceRNA network analyses, but no direct functional experiments were reported for this circRNA in the paper."	0.1768
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0043256		hsa_circ_ACACA	ACACA	Stomach Adenocarcinoma	MONDO:0005036	gastric adenocarcinoma	down-regulated	Microarray	"hsa_circ_0043256 is a down-regulated pan-circRNA identified by integrated microarray screening in pan-cancer and included for subsequent ceRNA-network predictions, but the current study did not report direct functional validation experiments for this circRNA."	0.1768
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0061749		hsa_circ_BRWD1	BRWD1	Stomach Adenocarcinoma	MONDO:0005036	gastric adenocarcinoma	down-regulated	Microarray	"hsa_circ_0061749 is a down-regulated pan-circRNA discovered by integrated microarray analysis across cancers and incorporated into the predicted pan-cancer ceRNA network, without direct functional assays reported for this circRNA."	0.1768
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0076798		hsa_circ_GCLC	GCLC	Stomach Adenocarcinoma	MONDO:0005036	gastric adenocarcinoma	down-regulated	Microarray	"hsa_circ_0076798 is a down-regulated pan-circRNA identified via integrated microarray screening, but it was reported to have no connection with the hub genes in the constructed network and no direct functional assays were presented for it."	0.1768
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0008310		hsa_circ_CNTROB	CNTROB	Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma	MONDO:0005131	cervical carcinoma	up-regulated	RT-qPCR; Microarray	"In pan-cancer, hsa_circ_0008310 is up-regulated and shows pro-malignant effects: its knockdown suppresses proliferation, migration, and invasion in cancer cell lines. The study predicts it may participate in a ceRNA network involving miR-3174 (and possibly miR-760) and downstream targets such as NUSAP1/NEK2/CENPI."	0.5008
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0004639		hsa_circ_NECTIN3	NECTIN3	Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma	MONDO:0005131	cervical carcinoma	down-regulated	RT-qPCR; Microarray	"In pan-cancer, hsa_circ_0004639 is down-regulated and acts as a tumor-suppressive circRNA in functional assays: its overexpression inhibits proliferation, migration, and invasion. The study predicts it may be involved in a ceRNA network affecting miR-3174 (and also miR-507/miR-4517 responses) with potential downstream targets including NUSAP1/NEK2/CENPI."	0.5008
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0020390		hsa_circ_DOCK1	DOCK1	Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma	MONDO:0005131	cervical carcinoma	down-regulated	Microarray	"hsa_circ_0020390 is identified as a down-regulated pan-circRNA in pan-cancer through integrated microarray screening and was included in predicted ceRNA network analyses, but no direct functional experiments were reported for this circRNA in the paper."	0.1768
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0043256		hsa_circ_ACACA	ACACA	Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma	MONDO:0005131	cervical carcinoma	down-regulated	Microarray	"hsa_circ_0043256 is a down-regulated pan-circRNA identified by integrated microarray screening in pan-cancer and included for subsequent ceRNA-network predictions, but the current study did not report direct functional validation experiments for this circRNA."	0.1768
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0061749		hsa_circ_BRWD1	BRWD1	Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma	MONDO:0005131	cervical carcinoma	down-regulated	Microarray	"hsa_circ_0061749 is a down-regulated pan-circRNA discovered by integrated microarray analysis across cancers and incorporated into the predicted pan-cancer ceRNA network, without direct functional assays reported for this circRNA."	0.1768
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0076798		hsa_circ_GCLC	GCLC	Cervical Squamous Cell Carcinoma and Endocervical Adenocarcinoma	MONDO:0005131	cervical carcinoma	down-regulated	Microarray	"hsa_circ_0076798 is a down-regulated pan-circRNA identified via integrated microarray screening, but it was reported to have no connection with the hub genes in the constructed network and no direct functional assays were presented for it."	0.1768
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0008310		hsa_circ_CNTROB	CNTROB	Thyroid Carcinoma	MONDO:0015075	thyroid gland carcinoma	up-regulated	RT-qPCR; Microarray	"In pan-cancer, hsa_circ_0008310 is up-regulated and shows pro-malignant effects: its knockdown suppresses proliferation, migration, and invasion in cancer cell lines. The study predicts it may participate in a ceRNA network involving miR-3174 (and possibly miR-760) and downstream targets such as NUSAP1/NEK2/CENPI."	0.5008
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0004639		hsa_circ_NECTIN3	NECTIN3	Thyroid Carcinoma	MONDO:0015075	thyroid gland carcinoma	down-regulated	RT-qPCR; Microarray	"In pan-cancer, hsa_circ_0004639 is down-regulated and acts as a tumor-suppressive circRNA in functional assays: its overexpression inhibits proliferation, migration, and invasion. The study predicts it may be involved in a ceRNA network affecting miR-3174 (and also miR-507/miR-4517 responses) with potential downstream targets including NUSAP1/NEK2/CENPI."	0.5008
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0020390		hsa_circ_DOCK1	DOCK1	Thyroid Carcinoma	MONDO:0015075	thyroid gland carcinoma	down-regulated	Microarray	"hsa_circ_0020390 is identified as a down-regulated pan-circRNA in pan-cancer through integrated microarray screening and was included in predicted ceRNA network analyses, but no direct functional experiments were reported for this circRNA in the paper."	0.1768
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0043256		hsa_circ_ACACA	ACACA	Thyroid Carcinoma	MONDO:0015075	thyroid gland carcinoma	down-regulated	Microarray	"hsa_circ_0043256 is a down-regulated pan-circRNA identified by integrated microarray screening in pan-cancer and included for subsequent ceRNA-network predictions, but the current study did not report direct functional validation experiments for this circRNA."	0.1768
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0061749		hsa_circ_BRWD1	BRWD1	Thyroid Carcinoma	MONDO:0015075	thyroid gland carcinoma	down-regulated	Microarray	"hsa_circ_0061749 is a down-regulated pan-circRNA discovered by integrated microarray analysis across cancers and incorporated into the predicted pan-cancer ceRNA network, without direct functional assays reported for this circRNA."	0.1768
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0076798		hsa_circ_GCLC	GCLC	Thyroid Carcinoma	MONDO:0015075	thyroid gland carcinoma	down-regulated	Microarray	"hsa_circ_0076798 is a down-regulated pan-circRNA identified via integrated microarray screening, but it was reported to have no connection with the hub genes in the constructed network and no direct functional assays were presented for it."	0.1768
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0008310		hsa_circ_CNTROB	CNTROB	Thyroid Carcinoma	MONDO:0015075	thyroid gland carcinoma	up-regulated	RT-qPCR; Microarray	"In pan-cancer, hsa_circ_0008310 is up-regulated and shows pro-malignant effects: its knockdown suppresses proliferation, migration, and invasion in cancer cell lines. The study predicts it may participate in a ceRNA network involving miR-3174 (and possibly miR-760) and downstream targets such as NUSAP1/NEK2/CENPI."	0.5008
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0004639		hsa_circ_NECTIN3	NECTIN3	Thyroid Carcinoma	MONDO:0015075	thyroid gland carcinoma	down-regulated	RT-qPCR; Microarray	"In pan-cancer, hsa_circ_0004639 is down-regulated and acts as a tumor-suppressive circRNA in functional assays: its overexpression inhibits proliferation, migration, and invasion. The study predicts it may be involved in a ceRNA network affecting miR-3174 (and also miR-507/miR-4517 responses) with potential downstream targets including NUSAP1/NEK2/CENPI."	0.5008
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0020390		hsa_circ_DOCK1	DOCK1	Thyroid Carcinoma	MONDO:0015075	thyroid gland carcinoma	down-regulated	Microarray	"hsa_circ_0020390 is identified as a down-regulated pan-circRNA in pan-cancer through integrated microarray screening and was included in predicted ceRNA network analyses, but no direct functional experiments were reported for this circRNA in the paper."	0.1768
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0043256		hsa_circ_ACACA	ACACA	Thyroid Carcinoma	MONDO:0015075	thyroid gland carcinoma	down-regulated	Microarray	"hsa_circ_0043256 is a down-regulated pan-circRNA identified by integrated microarray screening in pan-cancer and included for subsequent ceRNA-network predictions, but the current study did not report direct functional validation experiments for this circRNA."	0.1768
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0061749		hsa_circ_BRWD1	BRWD1	Thyroid Carcinoma	MONDO:0015075	thyroid gland carcinoma	down-regulated	Microarray	"hsa_circ_0061749 is a down-regulated pan-circRNA discovered by integrated microarray analysis across cancers and incorporated into the predicted pan-cancer ceRNA network, without direct functional assays reported for this circRNA."	0.1768
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0076798		hsa_circ_GCLC	GCLC	Thyroid Carcinoma	MONDO:0015075	thyroid gland carcinoma	down-regulated	Microarray	"hsa_circ_0076798 is a down-regulated pan-circRNA identified via integrated microarray screening, but it was reported to have no connection with the hub genes in the constructed network and no direct functional assays were presented for it."	0.1768
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0008310		hsa_circ_CNTROB	CNTROB	Liver Hepatocellular Carcinoma	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"In pan-cancer, hsa_circ_0008310 is up-regulated and shows pro-malignant effects: its knockdown suppresses proliferation, migration, and invasion in cancer cell lines. The study predicts it may participate in a ceRNA network involving miR-3174 (and possibly miR-760) and downstream targets such as NUSAP1/NEK2/CENPI."	0.5008
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0004639		hsa_circ_NECTIN3	NECTIN3	Liver Hepatocellular Carcinoma	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"In pan-cancer, hsa_circ_0004639 is down-regulated and acts as a tumor-suppressive circRNA in functional assays: its overexpression inhibits proliferation, migration, and invasion. The study predicts it may be involved in a ceRNA network affecting miR-3174 (and also miR-507/miR-4517 responses) with potential downstream targets including NUSAP1/NEK2/CENPI."	0.5008
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0020390		hsa_circ_DOCK1	DOCK1	Liver Hepatocellular Carcinoma	MONDO:0007256	hepatocellular carcinoma	down-regulated	Microarray	"hsa_circ_0020390 is identified as a down-regulated pan-circRNA in pan-cancer through integrated microarray screening and was included in predicted ceRNA network analyses, but no direct functional experiments were reported for this circRNA in the paper."	0.1768
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0043256		hsa_circ_ACACA	ACACA	Liver Hepatocellular Carcinoma	MONDO:0007256	hepatocellular carcinoma	down-regulated	Microarray	"hsa_circ_0043256 is a down-regulated pan-circRNA identified by integrated microarray screening in pan-cancer and included for subsequent ceRNA-network predictions, but the current study did not report direct functional validation experiments for this circRNA."	0.1768
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0061749		hsa_circ_BRWD1	BRWD1	Liver Hepatocellular Carcinoma	MONDO:0007256	hepatocellular carcinoma	down-regulated	Microarray	"hsa_circ_0061749 is a down-regulated pan-circRNA discovered by integrated microarray analysis across cancers and incorporated into the predicted pan-cancer ceRNA network, without direct functional assays reported for this circRNA."	0.1768
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0076798		hsa_circ_GCLC	GCLC	Liver Hepatocellular Carcinoma	MONDO:0007256	hepatocellular carcinoma	down-regulated	Microarray	"hsa_circ_0076798 is a down-regulated pan-circRNA identified via integrated microarray screening, but it was reported to have no connection with the hub genes in the constructed network and no direct functional assays were presented for it."	0.1768
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0008310		hsa_circ_CNTROB	CNTROB	Lung Adenocarcinoma	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"In pan-cancer, hsa_circ_0008310 is up-regulated and shows pro-malignant effects: its knockdown suppresses proliferation, migration, and invasion in cancer cell lines. The study predicts it may participate in a ceRNA network involving miR-3174 (and possibly miR-760) and downstream targets such as NUSAP1/NEK2/CENPI."	0.5008
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0004639		hsa_circ_NECTIN3	NECTIN3	Lung Adenocarcinoma	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; Microarray	"In pan-cancer, hsa_circ_0004639 is down-regulated and acts as a tumor-suppressive circRNA in functional assays: its overexpression inhibits proliferation, migration, and invasion. The study predicts it may be involved in a ceRNA network affecting miR-3174 (and also miR-507/miR-4517 responses) with potential downstream targets including NUSAP1/NEK2/CENPI."	0.5008
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0020390		hsa_circ_DOCK1	DOCK1	Lung Adenocarcinoma	MONDO:0005061	lung adenocarcinoma	down-regulated	Microarray	"hsa_circ_0020390 is identified as a down-regulated pan-circRNA in pan-cancer through integrated microarray screening and was included in predicted ceRNA network analyses, but no direct functional experiments were reported for this circRNA in the paper."	0.1768
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0043256		hsa_circ_ACACA	ACACA	Lung Adenocarcinoma	MONDO:0005061	lung adenocarcinoma	down-regulated	Microarray	"hsa_circ_0043256 is a down-regulated pan-circRNA identified by integrated microarray screening in pan-cancer and included for subsequent ceRNA-network predictions, but the current study did not report direct functional validation experiments for this circRNA."	0.1768
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0061749		hsa_circ_BRWD1	BRWD1	Lung Adenocarcinoma	MONDO:0005061	lung adenocarcinoma	down-regulated	Microarray	"hsa_circ_0061749 is a down-regulated pan-circRNA discovered by integrated microarray analysis across cancers and incorporated into the predicted pan-cancer ceRNA network, without direct functional assays reported for this circRNA."	0.1768
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0076798		hsa_circ_GCLC	GCLC	Lung Adenocarcinoma	MONDO:0005061	lung adenocarcinoma	down-regulated	Microarray	"hsa_circ_0076798 is a down-regulated pan-circRNA identified via integrated microarray screening, but it was reported to have no connection with the hub genes in the constructed network and no direct functional assays were presented for it."	0.1768
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0008310		hsa_circ_CNTROB	CNTROB	Colon Adenocarcinoma	MONDO:0002271	colon adenocarcinoma	up-regulated	RT-qPCR; Microarray	"In pan-cancer, hsa_circ_0008310 is up-regulated and shows pro-malignant effects: its knockdown suppresses proliferation, migration, and invasion in cancer cell lines. The study predicts it may participate in a ceRNA network involving miR-3174 (and possibly miR-760) and downstream targets such as NUSAP1/NEK2/CENPI."	0.5008
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0004639		hsa_circ_NECTIN3	NECTIN3	Colon Adenocarcinoma	MONDO:0002271	colon adenocarcinoma	down-regulated	RT-qPCR; Microarray	"In pan-cancer, hsa_circ_0004639 is down-regulated and acts as a tumor-suppressive circRNA in functional assays: its overexpression inhibits proliferation, migration, and invasion. The study predicts it may be involved in a ceRNA network affecting miR-3174 (and also miR-507/miR-4517 responses) with potential downstream targets including NUSAP1/NEK2/CENPI."	0.5008
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0020390		hsa_circ_DOCK1	DOCK1	Colon Adenocarcinoma	MONDO:0002271	colon adenocarcinoma	down-regulated	Microarray	"hsa_circ_0020390 is identified as a down-regulated pan-circRNA in pan-cancer through integrated microarray screening and was included in predicted ceRNA network analyses, but no direct functional experiments were reported for this circRNA in the paper."	0.1768
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0043256		hsa_circ_ACACA	ACACA	Colon Adenocarcinoma	MONDO:0002271	colon adenocarcinoma	down-regulated	Microarray	"hsa_circ_0043256 is a down-regulated pan-circRNA identified by integrated microarray screening in pan-cancer and included for subsequent ceRNA-network predictions, but the current study did not report direct functional validation experiments for this circRNA."	0.1768
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0061749		hsa_circ_BRWD1	BRWD1	Colon Adenocarcinoma	MONDO:0002271	colon adenocarcinoma	down-regulated	Microarray	"hsa_circ_0061749 is a down-regulated pan-circRNA discovered by integrated microarray analysis across cancers and incorporated into the predicted pan-cancer ceRNA network, without direct functional assays reported for this circRNA."	0.1768
33094914	Cancer medicine	2020	"Screening and bioinformatics analysis of a ceRNA network based on the circular RNAs, miRNAs, and mRNAs in pan-cancer."	hsa_circ_0076798		hsa_circ_GCLC	GCLC	Colon Adenocarcinoma	MONDO:0002271	colon adenocarcinoma	down-regulated	Microarray	"hsa_circ_0076798 is a down-regulated pan-circRNA identified via integrated microarray screening, but it was reported to have no connection with the hub genes in the constructed network and no direct functional assays were presented for it."	0.1768
33097010	BMC cancer	2020	Circular RNA hsa_circ_0000282 contributes to osteosarcoma cell proliferation by regulating miR-192/XIAP axis.	hsa_circ_0000282				osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"hsa_circ_0000282 is up-regulated in osteosarcoma tissues and cell lines and promotes osteosarcoma cell proliferation while inhibiting apoptosis. Mechanistically, it sponges miR-192 to relieve repression of XIAP, forming a circ_0000282/miR-192/XIAP ceRNA axis."	0.7032
33099538	Aging	2020	Down-regulated ciRS-7/up-regulated miR-7 axis aggravated cartilage degradation and autophagy defection by PI3K/AKT/mTOR activation mediated by IL-17A in osteoarthritis.		ciRS-7	hsa_circ_CDR1AS	CDR1AS	osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR	"This study investigates ciRS-7 as part of the ciRS-7/miR-7 axis in osteoarthritis, linking altered axis status to cartilage matrix degradation and impaired autophagy. The axis is connected mechanistically to IL-17A-associated PI3K/AKT/mTOR pathway activation in IL-1beta-stimulated chondrocytes, with supportive in vivo findings in a DMM rat OA model (via miR-7 modulation)."	0.6111
33101012	Frontiers in pharmacology	2020	Circular RNA Involved in the Protective Effect of Malva sylvestris L. on Myocardial Ischemic/Re-Perfused Injury.		rno_circ_003593			myocardial ischemia	MONDO:0024644	myocardial ischemia	up-regulated	RT-qPCR; Microarray	"Circ003593 (rat_circ_003593) is up-regulated in myocardial ischemia/reperfusion injury and in OGD/Re-treated H9c2 cells. Knockdown of circ003593 alleviates OGD/Re-induced loss of viability and apoptosis, suppresses the NLRP3 inflammasome components (NLRP3/ASC/cleaved caspase-1), and is associated with activation of RISK signaling (AKT and ERK1/2 phosphorylation)."	0.5089
33101367	Frontiers in genetics	2020	Construction of a circRNA-miRNA-mRNA Network Related to Macrophage Infiltration in Hepatocellular Carcinoma.	hsa_circ_0072088	circZFR	hsa_circ_ZFR	ZFR	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	unknown	Microarray	"hsa_circ_0072088 (circZFR) was included as a differentially expressed circRNA in the macrophage-related circRNA-miRNA-mRNA network for HCC; unlike the other four DEcircRNAs in the hub network, its direction of dysregulation was not specified. No experimental validation or specific macrophage-related functional mechanism was performed for this circRNA in the study."	0.1768
33101367	Frontiers in genetics	2020	Construction of a circRNA-miRNA-mRNA Network Related to Macrophage Infiltration in Hepatocellular Carcinoma.	hsa_circ_0004913				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	Microarray	"This study identified hsa_circ_0004913 as a downregulated DEcircRNA in HCC and placed it in the PRC1-centered circRNA-miRNA-mRNA network. The authors propose (without experimental validation) that hsa_circ_0004913 may sponge hsa-miR-182-5p to relieve inhibition of PRC1, potentially altering macrophage infiltration and promoting HCC progression."	0.1768
33101384	Frontiers in genetics	2020	Identification of Specific Circular RNA Expression Patterns and MicroRNA Interaction Networks in Mesial Temporal Lobe Epilepsy.		circRNA-CAMSAP1	hsa_circ_CAMSAP1	CAMSAP1	mesial temporal lobe epilepsy 	MONDO:0005115	temporal lobe epilepsy	dysregulated	RNA-seq	circRNA-CAMSAP1 is differentially expressed in temporal cortex tissue from MTLE patients versus controls based on RNA-seq and downstream computational analyses.	0.1768
33101384	Frontiers in genetics	2020	Identification of Specific Circular RNA Expression Patterns and MicroRNA Interaction Networks in Mesial Temporal Lobe Epilepsy.		circRNA-NMD3	hsa_circ_NMD3	NMD3	mesial temporal lobe epilepsy 	MONDO:0005115	temporal lobe epilepsy	up-regulated	RNA-seq	"circRNA-NMD3 is up-regulated in MTLE hippocampus and is analyzed as a putative miRNA sponge with 15 predicted/CLIP-supported miRNA binding interactions, associated with differential expression of downstream miRNA-target mRNAs and enriched functions including signal transduction/metabolism of proteins."	0.1768
33101384	Frontiers in genetics	2020	Identification of Specific Circular RNA Expression Patterns and MicroRNA Interaction Networks in Mesial Temporal Lobe Epilepsy.		circRNA-BNIP3L	hsa_circ_BNIP3L	BNIP3L	mesial temporal lobe epilepsy 	MONDO:0005115	temporal lobe epilepsy	up-regulated	RNA-seq	circRNA-BNIP3L is up-regulated in MTLE hippocampus and is computationally characterized for miRNA-binding capacity as part of circRNA_miRNA network analyses.	0.1768
33101384	Frontiers in genetics	2020	Identification of Specific Circular RNA Expression Patterns and MicroRNA Interaction Networks in Mesial Temporal Lobe Epilepsy.		circRNA-FBXL4	hsa_circ_FBXL4	FBXL4	mesial temporal lobe epilepsy 	MONDO:0005115	temporal lobe epilepsy	up-regulated	RNA-seq	"circRNA-FBXL4 is up-regulated in MTLE hippocampus and is analyzed as a miRNA sponge with many predicted/CLIP-supported miRNA binding sites (including hsa-miR-378 family), associated with broad downstream mRNA target dysregulation and enriched processes related to protein localization/modification."	0.1768
33101384	Frontiers in genetics	2020	Identification of Specific Circular RNA Expression Patterns and MicroRNA Interaction Networks in Mesial Temporal Lobe Epilepsy.		circRNA-TLL1	hsa_circ_TLL1	TLL1	mesial temporal lobe epilepsy 	MONDO:0005115	temporal lobe epilepsy	up-regulated	RNA-seq	circRNA-TLL1 is up-regulated in MTLE hippocampus and included in computational miRNA-binding/interaction network analyses.	0.1768
33101384	Frontiers in genetics	2020	Identification of Specific Circular RNA Expression Patterns and MicroRNA Interaction Networks in Mesial Temporal Lobe Epilepsy.		circRNA-RPS6KC1	hsa_circ_RPS6KC1	RPS6KC1	mesial temporal lobe epilepsy 	MONDO:0005115	temporal lobe epilepsy	up-regulated	RNA-seq	circRNA-RPS6KC1 is up-regulated in MTLE hippocampus and included in computational miRNA-binding analyses as part of circRNA-related regulatory network assessment.	0.1768
33101384	Frontiers in genetics	2020	Identification of Specific Circular RNA Expression Patterns and MicroRNA Interaction Networks in Mesial Temporal Lobe Epilepsy.		circRNA-HOMER1	hsa_circ_HOMER1	HOMER1	mesial temporal lobe epilepsy 	MONDO:0005115	temporal lobe epilepsy	down-regulated	RNA-seq	"circRNA-HOMER1 is down-regulated in MTLE hippocampus and is analyzed as a putative miRNA sponge with 12 predicted/CLIP-supported miRNA binding interactions, associated with altered expression of miRNA-target mRNAs and functional enrichments related to heterocyclic compound/ion binding in hippocampal neurons."	0.1768
33101498	Oncology letters	2020	"Esomeprazole affects the proliferation, metastasis, apoptosis and chemosensitivity of gastric cancer cells by regulating lncRNA/circRNA-miRNA-mRNA ceRNA networks."	hsa_circ_0008221				gastric cancer 	MONDO:0001056	gastric cancer	unknown	Microarray	"hsa_circ_0008221 was highlighted as a potential key node in the circRNA-miRNA-mRNA ceRNA network altered in AGS gastric cancer cells after esomeprazole treatment, based on microarray profiling and bioinformatic network construction."	0.1768
33101498	Oncology letters	2020	"Esomeprazole affects the proliferation, metastasis, apoptosis and chemosensitivity of gastric cancer cells by regulating lncRNA/circRNA-miRNA-mRNA ceRNA networks."	hsa_circ_0076332				gastric cancer 	MONDO:0001056	gastric cancer	unknown	Microarray	"hsa_circ_0076332 was implicated in a predicted ceRNA axis in AGS gastric cancer cells under esomeprazole treatment, acting as a ceRNA for hsa-miR-372-5p with downstream targets MAP2, HIPK2 and ANK2."	0.1768
33101498	Oncology letters	2020	"Esomeprazole affects the proliferation, metastasis, apoptosis and chemosensitivity of gastric cancer cells by regulating lncRNA/circRNA-miRNA-mRNA ceRNA networks."	hsa_circ_0059713				gastric cancer 	MONDO:0001056	gastric cancer	unknown	Microarray	"hsa_circ_0059713 was proposed (via bioinformatic ceRNA network analysis) to sponge hsa-miR-372-5p and thereby relate to regulation of MAP2, HIPK2 and ANK2 in AGS gastric cancer cells under esomeprazole treatment."	0.1768
33105568	International journal of molecular sciences	2020	Circular RNAs and Their Linear Transcripts as Diagnostic and Prognostic Tissue Biomarkers in Prostate Cancer after Prostatectomy in Combination with Clinicopathological Factors.	hsa_circ_0001246	circATXN10 	hsa_circ_ATXN10	ATXN10	prostate cancer 	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; Microarray	circATXN10 is down-regulated in prostate cancer tissue and serves as a diagnostic tissue biomarker for distinguishing malignant from adjacent normal prostate tissue. It was evaluated for BCR prediction but did not contribute independently when linear RNAs were considered.	0.6663
33105568	International journal of molecular sciences	2020	Circular RNAs and Their Linear Transcripts as Diagnostic and Prognostic Tissue Biomarkers in Prostate Cancer after Prostatectomy in Combination with Clinicopathological Factors.	hsa_circ_0007386	circCRIM1 	hsa_circ_CRIM1	CRIM1	prostate cancer 	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; Microarray	"circCRIM1 is down-regulated in prostate cancer tissue and was evaluated primarily as a diagnostic tissue biomarker distinguishing tumor from adjacent normal tissue, without mechanistic functional experiments in this study."	0.6663
33105568	International journal of molecular sciences	2020	Circular RNAs and Their Linear Transcripts as Diagnostic and Prognostic Tissue Biomarkers in Prostate Cancer after Prostatectomy in Combination with Clinicopathological Factors.	hsa_circ_0001522	circCSNK1G3 	hsa_circ_CSNK1G3	CSNK1G3	prostate cancer 	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; Microarray	circCSNK1G3 is down-regulated in prostate cancer tissue and was assessed mainly for diagnostic discrimination and BCR association analyses; this study did not perform functional mechanism experiments for it.	0.6813
33105568	International journal of molecular sciences	2020	Circular RNAs and Their Linear Transcripts as Diagnostic and Prognostic Tissue Biomarkers in Prostate Cancer after Prostatectomy in Combination with Clinicopathological Factors.	hsa_circ_0003759	circLPP 	hsa_circ_LPP	LPP	prostate cancer 	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; Microarray	"circLPP is down-regulated in prostate cancer tissue by RT-qPCR and shows diagnostic discrimination between tumor and adjacent normal tissue. It was included in circRNA-only Cox models for BCR prediction, though circRNAs did not improve BCR prediction when combined with linear RNAs."	0.6813
33105568	International journal of molecular sciences	2020	Circular RNAs and Their Linear Transcripts as Diagnostic and Prognostic Tissue Biomarkers in Prostate Cancer after Prostatectomy in Combination with Clinicopathological Factors.	hsa_circ_0000324	circNEAT1 	hsa_circ_NEAT1	NEAT1	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	"circNEAT1 is up-regulated in prostate cancer tissue but has very low abundance and poorer RT-qPCR performance, leading to exclusion from multivariable BCR prognostic modeling in this study. Its role here is primarily as a diagnostic expression marker rather than a mechanistically characterized regulator."	0.6663
33105568	International journal of molecular sciences	2020	Circular RNAs and Their Linear Transcripts as Diagnostic and Prognostic Tissue Biomarkers in Prostate Cancer after Prostatectomy in Combination with Clinicopathological Factors.	hsa_circ_0007444	circRHOBTB3 	hsa_circ_RHOBTB3	RHOBTB3	prostate cancer 	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; Microarray	"circRHOBTB3 is down-regulated in prostate cancer tissue and was evaluated as a tissue biomarker for distinguishing tumor from adjacent normal samples, without mechanistic functional validation in this study."	0.6663
33105568	International journal of molecular sciences	2020	Circular RNAs and Their Linear Transcripts as Diagnostic and Prognostic Tissue Biomarkers in Prostate Cancer after Prostatectomy in Combination with Clinicopathological Factors.	hsa_circ_0000069	circSTIL 	hsa_circ_STIL	STIL	prostate cancer 	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; Microarray	circSTIL is down-regulated in prostate cancer tissue by RT-qPCR and provides moderate diagnostic discrimination between tumor and adjacent normal tissue. It was not retained as an independent circRNA predictor for BCR in multivariable modeling.	0.6663
33106166	Molecular cancer	2020	CircECE1 activates energy metabolism in osteosarcoma by stabilizing c-Myc.	hsa_circ_0002402	CircECE1 	hsa_circ_ECE1	ECE1	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; RNA-seq	"CircECE1 (hsa_circ_0002402), derived from ECE1, is up-regulated in osteosarcoma tissues/cells and promotes proliferation, migration, metastasis, and enhanced glucose metabolism (Warburg effect). It binds c-Myc to block SPOP-mediated ubiquitination and degradation of c-Myc, thereby activating the c-Myc/TXNIP axis to drive metabolic reprogramming in OS."	0.8776
33109096	BMC pregnancy and childbirth	2020	circCRAMP1L is a novel biomarker of preeclampsia risk and may play a role in preeclampsia pathogenesis via regulation of the MSP/RON axis in trophoblasts.		circCRAMP1L 	hsa_circ_CRAMP1L	CRAMP1L	preeclampsia 	MONDO:0005081	preeclampsia	down-regulated	RT-qPCR	"circCRAMP1L is down-regulated in the plasma of patients with preeclampsia and is proposed as a diagnostic/predictive biomarker (ROC AUC 0.813; improved to 0.928 when combined with MSP). Functionally, circCRAMP1L regulates trophoblast proliferation and invasion through interaction with MSP and modulation of the MSP/RON axis."	0.8417
33109222	Diagnostic pathology	2020	Circ_0001421 facilitates glycolysis and lung cancer development by regulating miR-4677-3p/CDCA3.	hsa_circ_0001421	circ_0001421 	hsa_circ_SEC31A	SEC31A	Lung cancer 	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circ_0001421 is up-regulated in lung cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation, migration, invasion, glycolysis, and in vivo tumor growth by sponging miR-4677-3p to upregulate CDCA3, with associated increases in HK2 and glycolytic output."	0.6261
33109773	Aging	2020	Circular RNA circ_PVT1 induces epithelial-mesenchymal transition to promote metastasis of cervical cancer.	hsa_circ_0009143	circ_PVT1 	hsa_circ_PVT1	PVT1	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"circ_PVT1 (hsa_circ_0009143) is up-regulated in cervical cancer tissues/cells and in patient plasma/urine exosomes. Functionally, it promotes proliferation, migration, invasion, EMT and lung metastasis. Mechanistically, it acts as a miR-1286 sponge and can be transmitted via exosomes to activate EMT in recipient cells."	0.6791
33114016	International journal of molecular sciences	2020	Mapping a Circular RNA-microRNA-mRNA-Signaling Regulatory Axis That Modulates Stemness Properties of Cancer Stem Cell Populations in Colorectal Cancer Spheroid Cells.	hsa_circ_0066631	circ_0066631	hsa_circ_DCBLD2	DCBLD2	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0066631 is up-regulated in CSC-enriched CRC spheroid cells and acts as a miRNA sponge to suppress core miRNAs, thereby derepressing stemness-related mRNA targets involved in pluripotency-associated signaling pathways (e.g., GP130/Stat, TGF-beta/SMAD, Wnt/beta-catenin) and promoting stemness-associated phenotypes."	0.5719
33114016	International journal of molecular sciences	2020	Mapping a Circular RNA-microRNA-mRNA-Signaling Regulatory Axis That Modulates Stemness Properties of Cancer Stem Cell Populations in Colorectal Cancer Spheroid Cells.	hsa_circ_0082096	circ_0082096	hsa_circ_ZNF800	ZFN800	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0082096 is up-regulated in CSC-enriched CRC spheroid cells and sponges core miRNAs (including miR-140-3p, miR-382 and miR-579), leading to derepression of multiple mRNA targets (e.g., IL6ST/GP130, SMAD2, WNT5A) and activation of pluripotency-associated signaling that supports CSC stemness."	0.5719
33116589	OncoTargets and therapy	2020	Comprehensive Assessment of Plasma Circ_0004771 as a Novel Diagnostic and Dynamic Monitoring Biomarker in Gastric Cancer.	hsa_circ_0004771	circ_0004771	hsa_circ_NRIP1	NRIP1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"This study identifies plasma circ_0004771 (NRIP1-derived) as up-regulated in gastric cancer and demonstrates its value as a noninvasive diagnostic biomarker with good ROC performance. Its plasma level decreases after gastrectomy and increases again upon recurrence, supporting dynamic monitoring utility; a cytoplasmic ceRNA network with multiple predicted miRNAs is proposed but not experimentally validated."	0.6957
33116591	OncoTargets and therapy	2020	Circ-ELF2 Acts as a Competing Endogenous RNA to Facilitate Glioma Cell Proliferation and Aggressiveness by Targeting MiR-510-5p/MUC15 Signaling.		circ-ELF2 	hsa_circ_ELF2	ELF2	Glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR; Microarray	"circ-ELF2 is up-regulated in glioma and mainly localized in the cytoplasm. It promotes glioma cell proliferation, migration and invasion and inhibits apoptosis by functioning as a ceRNA that sponges miR-510-5p to upregulate MUC15. High circ-ELF2 expression is associated with worse overall survival and higher recurrence after surgery."	0.866
33116597	OncoTargets and therapy	2020	The Novel Circular RNA Circ-PGAP3 Promotes the Proliferation and Invasion of Triple Negative Breast Cancer by Regulating the miR-330-3p/Myc Axis.	hsa_circ_0106800	circ-PGAP3	hsa_circ_PGAP3	PGAP3	triple negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"circ-PGAP3 is up-regulated in TNBC tissues and promotes TNBC cell proliferation, invasion and metastasis in vitro and in vivo. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-330-3p, thereby increasing Myc expression. High circ-PGAP3 correlates with aggressive clinicopathological features and worse patient survival."	0.8556
33116616	OncoTargets and therapy	2020	Hsa_circ_0003645 Promotes Breast Cancer Progression by Regulating miR-139-3p/HMGB1 Axis.	hsa_circ_0003645	circ_0003645 			breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0003645 is up-regulated in breast cancer tissues and cell lines and acts oncogenically by promoting proliferation and suppressing apoptosis. Mechanistically, it functions as a ceRNA that sponges miR-139-3p to increase HMGB1 expression, supporting tumor growth in vitro and in a cell line-derived xenograft model."	0.7256
33116853	Cancer management and research	2020	"Circ_0032821 Facilitates Gastric Cancer Cell Proliferation, Migration, Invasion and Glycolysis by Regulating MiR-1236-3p/HMGB1 Axis."	hsa_circ_0032821	circ_0032821	hsa_circ_CEP128	CEP128	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_0032821 is up-regulated in gastric cancer tissues/cell lines and acts as an oncogenic circRNA. It promotes proliferation, migration/invasion and glycolysis, at least partly by sponging miR-1236-3p to increase HMGB1 expression, and its knockdown suppresses xenograft tumor growth."	0.7581
33116862	Cancer management and research	2020	Knockdown of circ-TTBK2 Inhibits Glioma Progression by Regulating miR-1283 and CHD1.	hsa_circ_0000594	circ-TTBK2 	hsa_circ_TTBK2	TTBK2	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ-TTBK2 is up-regulated in glioma tissues and cell lines and promotes malignant phenotypes including proliferation, migration, invasion and glycolysis. Mechanistically, circ-TTBK2 acts as a ceRNA by sponging miR-1283 to increase CHD1, and its knockdown suppresses tumor growth in a U251 xenograft model."	0.7581
33116874	Cancer management and research	2020	"Knockdown of CircCRIM1 Inhibits HDAC4 to Impede Osteosarcoma Proliferation, Migration, and Invasion and Facilitate Autophagy by Targeting miR-432-5p."	hsa_circ_0053958	circCRIM1 	hsa_circ_CRIM1	CRIM1	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circCRIM1 is up-regulated in osteosarcoma tissues and cell lines. It promotes proliferation, migration and invasion and suppresses autophagy by sponging miR-432-5p, which leads to increased HDAC4 expression and enhanced tumor growth in vivo."	0.6952
33116877	Cancer management and research	2020	CircRNA circUGGT2 Contributes to Hepatocellular Carcinoma Development via Regulation of the miR-526b-5p/RAB1A Axis.	hsa_circ_0008274	circUGGT2	hsa_circ_UGGT2	UGGT2	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circUGGT2 (hsa_circ_0008274) is up-regulated in HCC tissues and cell lines and is mainly localized in the cytoplasm. It promotes malignant phenotypes (proliferation, colony formation, cell-cycle progression, migration/invasion) and tumor growth by sponging miR-526b-5p to derepress RAB1A (circUGGT2/miR-526b-5p/RAB1A ceRNA axis)."	0.8206
33116893	Cancer management and research	2020	Oncolytic Vaccinia Virus-Mediated Antitumor Effect and Cell Proliferation Were Promoted in PTC by Regulating circRNA_103598/miR-23a-3p/IL-6 Axis.		circRNA_103598 			Papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"circRNA_103598 is up-regulated in papillary thyroid carcinoma and functions as an oncogenic circRNA. It sponges miR-23a-3p to increase IL-6 expression, promoting PTC cell proliferation and enhancing OVV-mediated antitumor effects via increased viral replication. Clinically, higher circRNA_103598 correlates with more advanced disease features and poorer overall survival, and shows ROC-based biomarker potential."	0.7588
33118329	Journal of cellular and molecular medicine	2020	Androgen receptor suppresses vasculogenic mimicry in hepatocellular carcinoma via circRNA7/miRNA7-5p/VE-cadherin/Notch4 signalling.		circRNA7 			hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"In HCC cells, AR suppresses circRNA7 expression by binding the circRNA7 host gene promoter. Reduced circRNA7 increases miR-7-5p activity, which represses VE-cadherin and Notch4, thereby inhibiting vasculogenic mimicry formation."	0.4844
33121269	Cell transplantation	2020	hsa_circ_102559 Acts as the Sponge of miR-130a-5p to Promote Hepatocellular Carcinoma Progression Through Regulation of ANXA2.		hsa_circ_102559 	hsa_circ_TMEM91	TMEM91	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_102559 is up-regulated in hepatocellular carcinoma and promotes proliferation, migration/invasion, EMT, and in vivo tumor growth/metastasis. Mechanistically, it mainly localizes in the cytoplasm and functions as a ceRNA sponge for miR-130a-5p, increasing ANXA2 expression. High expression is associated with worse overall survival and metastatic clinicopathologic features."	0.8457
33122916	OncoTargets and therapy	2020	Overexpression of hsa_circ_0001715 is a Potential Diagnostic and Prognostic Biomarker in Lung Adenocarcinoma.	hsa_circ_0001715		hsa_circ_LIMK1	LIMK1	lung adenocarcinoma	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001715 is up-regulated in lung adenocarcinoma tissues and elevated in patient plasma. Its plasma level correlates with TNM stage and distant metastasis, shows strong diagnostic performance (AUC 0.871), and high plasma expression predicts poorer overall survival as an independent prognostic factor."	0.6939
33122949	Cancer management and research	2020	Circ_0000260 Regulates the Development and Deterioration of Gastric Adenocarcinoma with Cisplatin Resistance by Upregulating MMP11 via Targeting MiR-129-5p.	hsa_circ_0000260	circ_0000260 	hsa_circ_SMC3	SMC3	gastric adenocarcinoma 	MONDO:0005036	gastric adenocarcinoma	up-regulated	RT-qPCR	"circ_0000260 (circSMC3, from SMC3) is up-regulated in GAC tumor tissues and serum-derived exosomes, especially in cisplatin-resistant cases. Functionally, it promotes cisplatin chemoresistance and malignant behaviors by acting as a ceRNA for miR-129-5p to increase MMP11 expression, and its knockdown sensitizes cells/tumors to cisplatin."	0.6545
33123285	Journal of Cancer	2020	Identification of hsa_circ_0039053 as an up-regulated and oncogenic circRNA in hepatocellular carcinoma via the miR-637-mediated USP21 activation.	hsa_circ_0039053	circITGAL	hsa_circ_ITGAL	ITGAL	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"In hepatocellular carcinoma, hsa_circ_0039053 (circITGAL) is up-regulated and promotes proliferation, invasion, and in vivo tumor growth. It predominantly localizes to the cytoplasm and functions as a ceRNA by sponging miR-637 to upregulate USP21."	0.8634
33124180	Journal of cellular and molecular medicine	2020	Circular RNA circCCDC9 alleviates ischaemic stroke ischaemia/reperfusion injury via the Notch pathway.		circCCDC9 	mmu_circ_CCDC9	CCDC9	ischaemic stroke 	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR	"In a mouse tMCAO cerebral ischaemia/reperfusion model, circCCDC9 is down-regulated in brain tissue. circCCDC9 overexpression protects blood-brain barrier integrity and reduces neuronal apoptosis, at least partly by suppressing Notch1 signaling (Notch1/NICD/Hes1), while circCCDC9 knockdown exacerbates injury."	0.414
33125087	International journal of molecular medicine	2020	Hypoxia_induced circCCDC66 promotes the tumorigenesis of colorectal cancer via the miR_3140/autophagy pathway.		circCCDC66	hsa_circ_CCDC66	CCDC66	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circCCDC66 is upregulated in colorectal cancer tissues/cell lines and further induced by hypoxia. Functionally, circCCDC66 promotes CRC cell viability, migration and invasion and suppresses apoptosis under hypoxic conditions by sponging miR-3140, thereby relieving miR-3140-mediated inhibition of autophagy."	0.6536
33125091	Oncology reports	2020	Sevoflurane suppresses cell viability and invasion and promotes cell apoptosis in colon cancer by modulating exosome_mediated circ_HMGCS1 via the miR_34a_5p/SGPP1 axis.		circ-HMGCS1 	hsa_circ_HMGCS1	HMGCS1	colon cancer	MONDO:0021063	malignant colon neoplasm	up-regulated	RT-qPCR	"circ-HMGCS1 is up-regulated in colon cancer (notably in serum- and cell-derived exosomes) and functions as an oncogenic circRNA. It sponges miR-34a-5p to increase SGPP1, thereby promoting proliferation/viability and invasion while inhibiting apoptosis; sevoflurane suppresses colon cancer progression partly by downregulating this exosome-transmitted circ-HMGCS1/miR-34a-5p/SGPP1 axis."	0.7045
33125858	Molecular therapy : the journal of the American Society of Gene Therapy	2021	Circular RNA circPDE4D Protects against Osteoarthritis by Binding to miR-103a-3p and Regulating FGF18.		circPDE4D	hsa_circ_PDE4D	PDE4D	Osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR; Northern Blot; ISH	"circPDE4D is down-regulated in osteoarthritic cartilage. It protects cartilage ECM homeostasis by sponging miR-103a-3p and releasing FGF18, thereby preserving Aggrecan and suppressing catabolic enzymes (e.g., MMP3/MMP13/ADAMTS4/5) and alleviating OA in a DMM mouse model."	0.872
33126850	BMC anesthesiology	2020	Bupivacaine suppresses the progression of gastric cancer through regulating circ_0000376/miR-145-5p axis.	hsa_circ_0000376				gastric cancer	MONDO:0001056	gastric cancer	unknown	RT-qPCR	"In AGS and HGC27 gastric cancer cells, circ_0000376 promotes malignant phenotypes (viability, migration/invasion, glycolysis) and suppresses apoptosis. Mechanistically, circ_0000376 sponges miR-145-5p and negatively regulates its level; bupivacaine decreases circ_0000376, thereby increasing miR-145-5p and inhibiting malignant behaviors."	0.5607
33131207	Molecular oncology	2021	Circular RNA profiling identifies circ102049 as a key regulator of colorectal liver metastasis.	hsa_circ_0043278	hsa_circ_102049 	hsa_circ_TADA2A	TADA2A	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circ102049 is up-regulated in CRC with liver metastasis and predicts poor survival. It promotes CRC cell adhesion/migration/invasion and liver metastasis mainly by sponging miR-761 and miR-192-3p to increase FRAS1, and it also binds DGCR8 to alter its localization, indirectly affecting miR-761/miR-192-3p maturation."	0.887
33133095	Frontiers in immunology	2020	Hsa_circ_0060450 Negatively Regulates Type I Interferon-Induced Inflammation by Serving as miR-199a-5p Sponge in Type 1 Diabetes Mellitus.	hsa_circ_0060450	circ_0450	hsa_circ_MYBL2	MYBL2	type 1 diabetes mellitus 	MONDO:0005147	type 1 diabetes mellitus	up-regulated	RT-qPCR; Microarray	"hsa_circ_0060450 is up-regulated in PBMCs from children with T1DM and is distributed in both nucleus and cytoplasm. It acts as a miR-199a-5p sponge to relieve repression of SHP2 (PTPN11), thereby suppressing IFN-I_triggered JAK-STAT1/3 activation and reducing macrophage inflammatory responses; it also shows diagnostic potential via ROC analysis in PBMCs."	0.8261
33133146	Frontiers in genetics	2020	Circular RNA Expression Profiling Identifies Glaucoma-Related Circular RNAs in Various Chronic Ocular Hypertension Rat Models.	hsa_circ_0023826		hsa_circ_TENM4	TENM4	glaucoma 	MONDO:0005041	glaucoma	down-regulated	RT-qPCR; RNA-seq	"This study identified hsa_circ_0023826 (from host gene TENM4) as down-regulated in glaucoma patient aqueous humor and proposed it as a diagnostic biomarker. Mechanistically, it was placed in a predicted circRNA_miRNA interaction network, targeting miR-146a-5p, miR-3543, miR-3553 and miR-539-5p."	0.5922
33133224	Computational and mathematical methods in medicine	2020	"circFAT1(e2) Promotes Papillary Thyroid Cancer Proliferation, Migration, and Invasion via the miRNA-873/ZEB1 Axis."		circFAT1(e2)	hsa_circ_FAT1	FAT1	papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circFAT1(e2) is up-regulated in papillary thyroid cancer tissues and cell lines and promotes PTC cell proliferation, migration, and invasion. Mechanistically, it functions as a ceRNA by sponging miR-873, leading to increased ZEB1 expression and enhanced malignant phenotypes."	0.6676
33135290	Journal of cellular and molecular medicine	2020	circRNA 001306 enhances hepatocellular carcinoma growth by up-regulating CDK16 expression via sponging miR-584-5p.		circ_1306 			hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circ_1306 (circRNA 001306) is up-regulated in HCC tissues and cell lines and promotes proliferation and tumour growth while inhibiting apoptosis. Mechanistically, it sponges miR-584-5p to de-repress CDK16, forming a circ_1306/miR-584-5p/CDK16 axis with potential diagnostic/therapeutic relevance in HCC."	0.7954
33138667	Bioengineered	2020	Circular RNA hsa_circ_0007364 increases cervical cancer progression through activating methionine adenosyltransferase II alpha (MAT2A) expression by restraining microRNA-101-5p.	hsa_circ_0007364	hsa_circRNA_100141 	hsa_circ_PTP4A2	PTP4A2	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0007364 is up-regulated in cervical cancer and is associated with advanced clinical features (FIGO stage and lymph-node metastasis). Functionally, it promotes cervical cancer cell proliferation and invasion and enhances xenograft tumor growth, mainly by sponging miR-101-5p to increase MAT2A expression (miR-101-5p/MAT2A axis)."	0.8432
33147167	Aging	2020	Dexmedetomidine inhibits inflammatory response and autophagy through the circLrp1b/miR-27a-3p/Dram2 pathway in a rat model of traumatic brain injury.		rno-circRNA_010705 	rno_circ_Lrp1b	Lrp1b	traumatic brain injury 	MONDO:0858950	traumatic brain injury	up-regulated	RT-qPCR; Northern Blot	"In rat TBI, circLrp1b is up-regulated and promotes autophagy and inflammatory injury by sponging miR-27a-3p to increase Dram2. Dexmedetomidine alleviates TBI-associated autophagy/inflammation in vivo partly through inactivation of the circLrp1b/miR-27a-3p/Dram2 axis."	0.8146
33149606	OncoTargets and therapy	2020	Microarray Expression Profiles and Bioinformatics Analyses Reveal Aberrant Circular RNAs Expression in Bladder Cancer.	hsa_circ_0006168	hsa_circRNA_103670	hsa_circ_CNOT6L	CNOT6L	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_103670 is up-regulated in bladder cancer tissues versus paired para-carcinoma normal tissues (microarray and RT-qPCR validation). The study predicts it may act as a miRNA sponge, with candidate target miRNAs including miR-570-5p, miR-592, miR-542-3p, miR-628-5p and miR-148b-5p. Higher hsa_circRNA_103670 expression is associated with high histological grade and poor T stage."	0.5135
33149606	OncoTargets and therapy	2020	Microarray Expression Profiles and Bioinformatics Analyses Reveal Aberrant Circular RNAs Expression in Bladder Cancer.	hsa_circ_0000367	hsa_circRNA_000367	hsa_circ_SIAE	SIAE	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_000367 is down-regulated in bladder cancer tissues versus paired para-carcinoma normal tissues (microarray and RT-qPCR validation). The study predicts it may sponge miRNAs including miR-331-3p, miR-4646-5p, miR-4797-5p, miR-3919 and miR-3190-3p. Higher hsa_circRNA_000367 expression correlates with earlier T stage."	0.5135
33149615	OncoTargets and therapy	2020	Hsa_circRNA_100146 Acts as a Sponge of miR-149-5p in Promoting Bladder Cancer Progression via Regulating RNF2.	hsa_circ_0011385	hsa_circRNA_100146 			bladder cancer	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circRNA_100146 is up-regulated in bladder cancer tissues and cell lines and its high expression predicts poor prognosis. Functionally, it promotes proliferation, migration and invasion and inhibits apoptosis in vitro, and enhances tumor growth in a xenograft model. Mechanistically, it acts as a ceRNA that sponges miR-149-5p to increase RNF2 expression."	0.8071
33149675	Cancer management and research	2020	circRNA Hsa_circ_0020850 Silence Represses the Development of Lung Adenocarcinoma via Regulating miR-195-5p/IRS2 Axis.	hsa_circ_0020850	circ_0020850	hsa_circ_NUP98	NUP98	lung adenocarcinoma	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"In lung adenocarcinoma, circ_0020850 is up-regulated and functions as an oncogenic circRNA. Silencing circ_0020850 inhibits proliferation, migration and invasion, promotes apoptosis, and reduces xenograft tumor growth by sponging miR-195-5p to increase IRS2 expression."	0.6835
33150086	PeerJ	2020	Construction and analysis of macrophage infiltration related circRNA-miRNA-mRNA regulatory networks in hepatocellular carcinoma.	hsa_circ_0007456				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	dysregulated	Microarray	"This study identifies hsa_circ_0007456 as a hub circRNA in a macrophage-infiltration-related circRNA-miRNA-mRNA network in HCC. It directly binds hsa-miR-139-5p in a binding-site-dependent luciferase reporter assay, supporting a miRNA-sponge (ceRNA) mechanism potentially affecting the miR-139-5p_CDCA8/KPNA2/PRC1/TOP2A subnetwork."	0.4375
33153123	International journal of molecular sciences	2020	Emerging Role for Linear and Circular Spermine Oxidase RNAs in Skeletal Muscle Physiopathology.		circSMOX 	mmu_circ_SMOX	SMOX	skeletal muscle atrophy 	MONDO:0005583	non-human animal disease	up-regulated	RT-qPCR	"circSMOX (from the SMOX gene, exons 2_3) is experimentally validated in mouse muscle cells and is significantly up-regulated in muscle atrophy models (DEXA-treated C2C12 myotubes) and in two ALS mouse models with progressive muscle atrophy. circSMOX is predominantly cytoplasmic; the study suggests (without direct testing) it may act as a miRNA sponge and/or could be translated from a putative ORF, and it is proposed as a potential biomarker/therapeutic target for atrophy/ALS monitoring."	0.6571
33153390	Technology in cancer research & treatment	2020	Circular RNA circ_0032462 Enhances Osteosarcoma Cell Progression by Promoting KIF3B Expression.	hsa_circ_0032462	circ_0032462			osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ_0032462 (hsa_circ_0032462) is up-regulated in osteosarcoma cell lines and promotes proliferation, migration, and invasion. It enhances KIF3B mRNA/protein expression, and KIF3B is required for circ_0032462-driven oncogenic phenotypes."	0.528
33153478	Molecular cancer	2020	circCUL2 regulates gastric cancer malignant transformation and cisplatin resistance by modulating autophagy activation via miR-142-3p/ROCK2.	hsa_circ_0000234	circCUL2	hsa_circ_CUL2	CUL2	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"circCUL2 is down-regulated in gastric cancer tissues, serum, and cell lines and acts as a tumor suppressor. It sponges miR-142-3p to upregulate ROCK2, thereby inhibiting malignant behaviors and autophagy, and increasing cisplatin sensitivity (reducing cisplatin resistance) in GC."	0.8981
33154193	Aging	2020	Hsa_circ_0043278 functions as competitive endogenous RNA to enhance glioblastoma multiforme progression by sponging miR-638.	hsa_circ_0043278	hsa_circRNA_0043278 	hsa_circ_TADA2A	TADA2A	glioblastoma multiforme 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR	"circ_0043278 is up-regulated in GBM tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion and in vivo tumor growth). Mechanistically, it acts as a ceRNA that sponges miR-638, leading to increased HOXA9 and activation of Wnt/beta-catenin signaling."	0.6478
33154349	Nature communications	2020	A circular RNA generated from an intron of the insulin gene controls insulin secretion.			mmu_circ_Ins2	Ins2	type 2 diabetes	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RT-qPCR; RNA-seq	"ci-Ins2 (a lariat-derived intronic circular RNA from Ins2 intron 2) supports beta-cell insulin secretion by maintaining transcription of multiple secretory machinery genes, at least partly via interaction with the RBP TDP-43. Its level is decreased in rodent type 2 diabetes models, consistent with beta-cell secretory dysfunction."	0.7536
33154349	Nature communications	2020	A circular RNA generated from an intron of the insulin gene controls insulin secretion.			rno_circ_Ins2	Ins2	type 2 diabetes	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RT-qPCR; RNA-seq	"ci-Ins2 (a lariat-derived intronic circular RNA from Ins2 intron 2) supports beta-cell insulin secretion by maintaining transcription of multiple secretory machinery genes, at least partly via interaction with the RBP TDP-43. Its level is decreased in rodent type 2 diabetes models, consistent with beta-cell secretory dysfunction."	0.7536
33154349	Nature communications	2020	A circular RNA generated from an intron of the insulin gene controls insulin secretion.			hsa_circ_INS	INS	type 2 diabetes	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RT-qPCR	"Human ci-INS promotes glucose- and depolarization-induced insulin secretion in human islets; its silencing reduces stimulated insulin release. In clinical islet samples, ci-INS is reduced in type 2 diabetes and inversely correlates with HbA1c, linking it to beta-cell dysfunction."	0.7241
33154668	Cancer management and research	2020	CircRAD18 Accelerates the Progression of Acute Myeloid Leukemia by Modulation of miR-206/PRKACB Axis.	hsa_circ_0001264	circRAD18 	hsa_circ_RAD18	RAD18	acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"circRAD18 is up-regulated in AML patient blood and AML cell lines. It promotes malignant phenotypes (proliferation, migration/invasion, cell-cycle progression) and inhibits apoptosis by sponging miR-206, thereby increasing PRKACB expression (circRAD18/miR-206/PRKACB axis)."	0.7181
33159017	Aging	2020	CircGLCE alleviates intervertebral disc degeneration by regulating apoptosis and matrix degradation through the targeting of miR-587/STAP1.		CircGLCE 	hsa_circ_GLCE	GLCE	intervertebral disc degeneration 	MONDO:0011385	intervertebral disk degenerative disorder	down-regulated	RT-qPCR; Northern Blot; ISH; Microarray	"CircGLCE is down-regulated in intervertebral disc degeneration and mainly localizes to the cytoplasm of nucleus pulposus cells. It functions as a ceRNA sponge for miR-587 to relieve repression of STAP1, thereby inhibiting NP cell apoptosis and reducing matrix-degrading enzymes (e.g., MMP13, ADAMTS5) to alleviate IDD in vitro and in a puncture-induced mouse model."	0.866
33159345	Journal of clinical laboratory analysis	2021	Low expression of hsa_circ_0001811 in gastric cancer and its role in clinical diagnosis.	hsa_circ_0001811		hsa_circ_STAU2	STAU2	gastric cancer	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"hsa_circ_0001811 is significantly down-regulated in gastric cancer tissues and in preoperative patient plasma. Its tissue and plasma levels show diagnostic utility by ROC analysis, and lower expression is associated with several clinicopathological features, supporting its potential as a non-invasive diagnostic biomarker."	0.5958
33160353	BMC medical genomics	2020	Genomic analysis of circular RNAs in heart.		circSCAF8_e4:TIAM2_e1			dilated cardiomyopathy 	MONDO:0005021	dilated cardiomyopathy	down-regulated	RNA-seq	This rt-circRNA derived from the SCAF8 and TIAM2 loci is significantly down-regulated in human DCM left ventricle based on RNA-seq differential expression analysis.	0.1155
33160353	BMC medical genomics	2020	Genomic analysis of circular RNAs in heart.		circSCAF8_e4:TIAM2_e2			dilated cardiomyopathy 	MONDO:0005021	dilated cardiomyopathy	down-regulated	RNA-seq	circSCAF8_e4:TIAM2_e2 is down-regulated in human DCM left ventricle and is predicted to sponge miR-150-5p and miR-17. The paper proposes a circSCAF8_e4:TIAM2_e2_miR-17_SCN2B regulatory axis whereby reduced circRNA may release miR-17 to suppress its downstream cardiac-related targets.	0.1768
33160353	BMC medical genomics	2020	Genomic analysis of circular RNAs in heart.		circALMS1_6	hsa_circ_ALMS1	ALMS1	dilated cardiomyopathy 	MONDO:0005021	dilated cardiomyopathy	unknown	RNA-seq	"circALMS1_6 is a cardiac circRNA predicted (by TargetScan-based binding site analysis) to be a strong miRNA sponge, especially for miR-133a-5p and miR-133a-3p, which are implicated in cardiac remodeling/hypertrophy."	0.1768
33169172	Molecular medicine reports	2021	Expression profile and diagnostic value of circRNAs in peripheral blood from patients with systemic lupus erythematosus.	hsa_circ_0082688				systemic lupus erythematosus 	MONDO:0007915	systemic lupus erythematosus	up-regulated	RT-qPCR; Microarray	hsa_circ_0082688 is significantly up-regulated in peripheral blood of adult SLE patients and shows diagnostic value versus healthy controls (ROC AUC 0.714). The study only performed miRNA target prediction (suggesting a possible miRNA-sponge role) without functional mechanistic validation; expression correlates negatively with C3 and monocyte count in SLE.	0.6089
33169172	Molecular medicine reports	2021	Expression profile and diagnostic value of circRNAs in peripheral blood from patients with systemic lupus erythematosus.	hsa_circ_0082689				systemic lupus erythematosus 	MONDO:0007915	systemic lupus erythematosus	up-regulated	RT-qPCR; Microarray	"hsa_circ_0082689 is significantly up-regulated in peripheral blood of adult SLE patients and has diagnostic value (highest AUC 0.733 among the tested circRNAs). In combination with hsa_circ_0082688, it forms a diagnostic model that distinguishes SLE from RA and healthy controls; mechanistically, only predicted miRNA interactions were explored without direct validation."	0.6089
33169172	Molecular medicine reports	2021	Expression profile and diagnostic value of circRNAs in peripheral blood from patients with systemic lupus erythematosus.	hsa_circ_0008675				systemic lupus erythematosus 	MONDO:0007915	systemic lupus erythematosus	up-regulated	RT-qPCR; Microarray	hsa_circ_0008675 is significantly up-regulated in peripheral blood of adult SLE patients and shows modest diagnostic performance versus healthy controls (AUC 0.643). The study did not experimentally validate function or downstream targets; only computational miRNA target prediction was performed for possible sponge activity.	0.6089
33169939	Journal of cellular and molecular medicine	2020	Circ_0067835 sponges miR-324-5p to induce HMGA1 expression in endometrial carcinoma cells.	hsa_circ_0067835	circ_0067835 			endometrial cancer 	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR	"circ_0067835 is up-regulated in endometrial carcinoma and promotes malignant phenotypes (proliferation, migration, invasion) while inhibiting apoptosis. Mechanistically, it sponges miR-324-5p to up-regulate HMGA1, supporting tumor growth in a cell line-derived xenograft model."	0.7554
33172486	Molecular cancer	2020	Circular RNA hsa_circ_0004872 inhibits gastric cancer progression via the miR-224/Smad4/ADAR1 successive regulatory circuit.	hsa_circ_0004872	circMAPK1 	hsa_circ_MAPK1	MAPK1	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0004872 (circMAPK1) is down-regulated in gastric cancer and functions as a tumor suppressor. It mainly localizes to the cytoplasm and sponges miR-224, thereby increasing p21 and Smad4 expression and inhibiting proliferation, invasion/migration, and metastasis. The study proposes a negative feedback circuit in which ADAR1 suppresses hsa_circ_0004872, while Smad4 represses ADAR1 transcription, collectively modulating the hsa_circ_0004872/miR-224 axis."	0.886
33173313	OncoTargets and therapy	2020	Upregulated circPDK1 Promotes RCC Cell Migration and Invasion by Regulating the miR-377-3P-NOTCH1 Axis in Renal Cell Carcinoma.		circPDK1 	hsa_circ_PDK1	PDK1	renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circPDK1 is up-regulated in RCC tissues and cell lines and promotes RCC cell migration, invasion, and lung metastasis in a xenograft model. Mechanistically, circPDK1 localizes mainly in the cytoplasm and acts as a ceRNA sponge for miR-377-3P, thereby increasing NOTCH1 expression and enhancing metastatic behavior."	0.7736
33173333	Cancer management and research	2020	Circ_0109046 Promotes the Progression of Endometrial Cancer via Regulating miR-136/HMGA2 Axis.	hsa_circ_0109046		hsa_circ_ALB		Endometrial cancer 	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR	"circ_0109046 is up-regulated in endometrial cancer tissues/cells and promotes malignant phenotypes (proliferation, migration, invasion and EMT) and xenograft tumor growth. Mechanistically, it mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-136 to relieve repression of HMGA2. High circ_0109046 expression is associated with poor overall survival and more aggressive clinicopathological features."	0.7788
33173336	Cancer management and research	2020	Circ-ATP5H Induces Hepatitis B Virus Replication and Expression by Regulating miR-138-5p/TNFAIP3 Axis.	hsa_circ_0006942	circ-ATP5H	hsa_circ_ATP5H	ATP5H	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ-ATP5H (hsa_circ_0006942) is up-regulated in HBV-positive HCC tissues and HBV-producing HCC cells. Functionally, circ-ATP5H promotes HBV DNA replication and viral antigen (HBsAg/HBeAg) production by sponging miR-138-5p to up-regulate TNFAIP3, forming a circ-ATP5H/miR-138-5p/TNFAIP3 ceRNA axis."	0.6369
33173347	Cancer management and research	2020	"Ropivacaine Inhibits Cell Proliferation, Migration and Invasion, Whereas Induces Oxidative Stress and Cell Apoptosis by circSCAF11/miR-145-5p Axis in Glioma."		circSCAF11	hsa_circ_SCAF11	SCAF11	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circSCAF11 is up-regulated in glioma tissues and cell lines and promotes malignant phenotypes. It sponges miR-145-5p (validated by luciferase and Ago2-RIP), thereby reducing oxidative stress and apoptosis while enhancing proliferation, migration, invasion/EMT; ropivacaine suppresses glioma partly by downregulating circSCAF11 and restoring miR-145-5p."	0.7949
33173349	Cancer management and research	2020	Circ_0072995 Promotes Cell Carcinogenesis via Up-Regulating miR-149-5p-Mediated SHMT2 in Breast Cancer.	hsa_circ_0072995	Circ_0072995	hsa_circ_RGNEF	RGNEF	breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"Circ_0072995 is up-regulated in breast cancer tissues and cell lines and acts as an oncogenic circRNA. It sponges miR-149-5p to increase SHMT2 expression, promoting malignant phenotypes and anaerobic glycolysis, and its silencing suppresses xenograft tumor growth."	0.7591
33173957	Molecular medicine reports	2020	Exosomal circular RNA_400068 promotes the development of renal cell carcinoma via the miR_210_5p/SOCS1 axis.		circular RNA (circ)_400068 			renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR; Microarray	"Exosomal circ_400068 is up-regulated in RCC and promotes proliferation while inhibiting apoptosis in recipient kidney cells. Mechanistically, it targets miR-210-5p and modulates SOCS1 via a circ_400068/miR-210-5p/SOCS1 axis, suggesting biomarker and therapeutic potential in RCC."	0.6777
33173985	Molecular medicine reports	2020	Differentially expressed circular RNAs in a murine asthma model.	mmu_circ_0000455	circ_0000455			allergic asthma 	MONDO:0004784	allergic asthma	up-regulated	RT-qPCR; RNA-seq	"mmu_circ_0000455 is up-regulated in HDM-induced murine asthma lung tissue. Bioinformatic prediction suggests it may interact with miR-29b, implying a potential miRNA-sponge role in asthma-related regulation."	0.5922
33173985	Molecular medicine reports	2020	Differentially expressed circular RNAs in a murine asthma model.	mmu_circ_0000629	circ_0000629			allergic asthma 	MONDO:0004784	allergic asthma	up-regulated	RT-qPCR; RNA-seq	"mmu_circ_0000629 is up-regulated in HDM-induced murine asthma lung tissue. Bioinformatic prediction suggests it may interact with miR-15a, indicating a potential miRNA-sponge role relevant to asthma regulation."	0.5922
33173985	Molecular medicine reports	2020	Differentially expressed circular RNAs in a murine asthma model.	mmu_circ_0001454	circ_0001454			allergic asthma 	MONDO:0004784	allergic asthma	unknown	RNA-seq	"mmu_circ_0001454 is a candidate downregulated circRNA from sequencing in an HDM-induced murine asthma model. Predicted network analysis suggests it may target miR-146b, implying a potential miRNA-sponge relationship relevant to asthma."	0.5922
33173985	Molecular medicine reports	2020	Differentially expressed circular RNAs in a murine asthma model.	mmu_circ_0000723	circ_0000723			allergic asthma 	MONDO:0004784	allergic asthma	down-regulated	RT-qPCR; RNA-seq	"mmu_circ_0000723 is down-regulated in HDM-induced murine asthma lung tissue. Network prediction suggests it targets miR-214, supporting a potential miRNA-sponge role in asthma-associated regulation."	0.5922
33176280	Aging	2020	Circular RNA circSEMA5A promotes bladder cancer progression by upregulating ENO1 and SEMA5A expression.	hsa_circ_0071820	circSEMA5A	hsa_circ_SEMA5A	SEMA5A	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circSEMA5A is upregulated in bladder cancer and promotes malignant phenotypes (proliferation, migration/invasion, angiogenesis) while inhibiting apoptosis and enhancing glycolysis. It functions via a ceRNA axis circSEMA5A/miR-330-5p/ENO1 that activates Akt and beta-catenin signaling, and also recruits EIF4A3 to stabilize SEMA5A mRNA to promote angiogenesis."	0.8279
33177084	Science advances	2020	Circular RNAs from BOULE play conserved roles in protection against stress-induced fertility decline.		circEx2-3	dme_circ_boule	boule	stress-induced fertility decline 	MONDO:0005047	infertility disorder	unknown	RT-qPCR; Northern Blot	"In Drosophila, circEx2-3 (a circBoule RNA) protects male fertility under heat stress and helps maintain normal sperm number and morphology. Mechanistically, it binds heat shock proteins Hsc4 and Hsp60C and promotes their ubiquitination, contributing to lower HSP protein levels during heat stress."	0.7326
33177084	Science advances	2020	Circular RNAs from BOULE play conserved roles in protection against stress-induced fertility decline.		circEx4-7	dme_circ_boule	boule	stress-induced fertility decline 	MONDO:0005047	infertility disorder	unknown	RT-qPCR; Northern Blot	"In Drosophila, circEx4-7 (a circBoule RNA) helps protect male fertility and sperm quality during heat stress. It binds Hsc4 and Hsp60C and contributes to their ubiquitination-mediated down-regulation."	0.7326
33177084	Science advances	2020	Circular RNAs from BOULE play conserved roles in protection against stress-induced fertility decline.		circEx3-6 	mmu_circ_Boule	Boule	stress-induced fertility decline 	MONDO:0005047	infertility disorder	down-regulated	RT-qPCR	"Mouse circEx3-6 binds HSPA2 in sperm and promotes HSPA2 ubiquitination, contributing to proper reduction of HSPA2 during sperm maturation/capacitation. Loss of circBoule RNAs (including circEx3-6) compromises fertilization ability particularly under heat stress, and mouse circEx3-6 can partially rescue heat-stress fertility decline in circBoule-KO flies."	0.7353
33177084	Science advances	2020	Circular RNAs from BOULE play conserved roles in protection against stress-induced fertility decline.		circEx3-5	mmu_circ_Boule	Boule	stress-induced fertility decline 	MONDO:0005047	infertility disorder	unknown	RT-qPCR; Northern Blot	"Mouse circEx3-5 is a Boule-derived circRNA eliminated in the circBoule-KO mice and can bind HSPA2 in testis, supporting a conserved circBoule_HSP interaction framework implicated in fertility protection under heat stress."	0.4468
33177084	Science advances	2020	Circular RNAs from BOULE play conserved roles in protection against stress-induced fertility decline.		circEx3-7	mmu_circ_Boule	Boule	stress-induced fertility decline 	MONDO:0005047	infertility disorder	unknown	RT-qPCR; Northern Blot	"Mouse circEx3-7 is a Boule-derived circRNA removed in the circBoule-KO mice and interacts with HSPA2 in testis, consistent with a conserved circBoule_HSP interaction implicated in maintaining male fertility under heat stress."	0.4468
33177084	Science advances	2020	Circular RNAs from BOULE play conserved roles in protection against stress-induced fertility decline.		circEx3-6	hsa_circ_BOULE	BOULE	asthenozoospermia	MONDO:0100459	azoospermia	down-regulated	RT-qPCR	"In human sperm, circEx3-6 is down-regulated in asthenozoospermia and physically interacts with HSPA2. In normozoospermic samples, circEx3-6 levels are negatively correlated with HSPA2 protein, suggesting involvement in HSPA2 regulation relevant to sperm motility/fertility."	0.5917
33177084	Science advances	2020	Circular RNAs from BOULE play conserved roles in protection against stress-induced fertility decline.		circEx2-7	hsa_circ_BOULE	BOULE	asthenozoospermia	MONDO:0100459	azoospermia	down-regulated	RT-qPCR	"In human sperm, circEx2-7 is down-regulated in asthenozoospermia and interacts with HSPA2, supporting a conserved circBoule_HSPA2 interaction potentially relevant to sperm motility-related infertility."	0.5129
33177837	OncoTargets and therapy	2020	"Circ_0057553/miR-515-5p Regulates Prostate Cancer Cell Proliferation, Apoptosis, Migration, Invasion and Aerobic Glycolysis by Targeting YES1."	hsa_circ_0057553	circ_0057553	hsa_circ_SLC39A10	SLC39A10	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circ_0057553 is up-regulated in prostate cancer tissues and cell lines and promotes proliferation/viability, migration, invasion and glycolysis while inhibiting apoptosis. Mechanistically, it binds (sponges) miR-515-5p to derepress YES1, and circ_0057553 knockdown suppresses xenograft tumor growth."	0.7792
33177838	OncoTargets and therapy	2020	Hsa_circ_0006916 Knockdown Represses the Development of Hepatocellular Carcinoma via Modulating miR-599/SRSF2 Axis.	hsa_circ_0006916	circ_0006916	hsa_circ_HOMER1	HOMER1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	circ_0006916 is up-regulated in HCC tissues and cell lines. Its knockdown suppresses malignant phenotypes in vitro and tumor growth in a xenograft model by acting as a ceRNA to sponge miR-599 and thereby reduce SRSF2 expression.	0.7951
33177875	Cancer management and research	2020	Circ_0061825 Acts as a miR-593-3p Sponge to Promote Breast Cancer Progression by Regulating FGFR3 Expression.	hsa_circ_0061825	circ_0061825 	hsa_circ_TFF1	TFF1	Breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0061825 (circ_TFF1) is up-regulated in breast cancer and mainly cytoplasmic. It promotes malignant phenotypes and tumor growth by acting as a ceRNA sponge for miR-593-3p, thereby increasing FGFR3 expression."	0.7801
33177876	Cancer management and research	2020	Down-Regulation of Circ_0032833 Sensitizes Colorectal Cancer to 5-Fluorouracil and Oxaliplatin Partly Depending on the Regulation of miR-125-5p and MSI1.	hsa_circ_0032833	circ_0032833			colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0032833 is up-regulated in FOLFOX-resistant colorectal cancer and promotes resistance to 5-fluorouracil and oxaliplatin. Mechanistically, it sponges miR-125-5p to increase MSI1 expression, thereby enhancing malignant behaviors and decreasing chemosensitivity; its knockdown sensitizes tumors in vitro and in a cell line-derived xenograft model."	0.705
33178826	BioMed research international	2020	Differential Expression and Bioinformatic Analysis of the circRNA Expression in Migraine Patients.	hsa_circ_0006168	hsa_circRNA_103670	hsa_circ_CNOT6L	CNOT6L	Migraine 	MONDO:0005277	migraine disorder	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_103670 (hsa_circ_0006168) is up-regulated in migraine patient plasma and was validated by qRT-PCR. Bioinformatic predictions place it in a circRNA_miRNA_mRNA (ceRNA) network and suggest a possible link to PI3K/AKT-related inflammatory processes in migraine, but no direct functional experiments were performed."	0.5135
33178826	BioMed research international	2020	Differential Expression and Bioinformatic Analysis of the circRNA Expression in Migraine Patients.	hsa_circ_0072088	hsa_circRNA_103809	hsa_circ_ZFR	ZFR	Migraine 	MONDO:0005277	migraine disorder	up-regulated	Microarray	"hsa_circRNA_103809 (hsa_circ_0072088) was identified by microarray as up-regulated in migraine plasma, but the abstract reports it as reduced versus controls, creating an unresolved direction conflict. It was included in predicted ceRNA network analyses, with a hypothesized connection to PI3K/AKT-associated inflammation in migraine."	0.4685
33178826	BioMed research international	2020	Differential Expression and Bioinformatic Analysis of the circRNA Expression in Migraine Patients.	hsa_circ_0000367	hsa_circRNA_000367	hsa_circ_SIAE	SIAE	Migraine 	MONDO:0005277	migraine disorder	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_000367 (hsa_circ_0000367) is down-regulated in migraine patient plasma and validated by qRT-PCR. It was used for GO/KEGG and ceRNA-network predictions, with suggested links to PI3K/AKT-related inflammatory mechanisms, and is highlighted as a potential regulator of migraine pathology."	0.5135
33178826	BioMed research international	2020	Differential Expression and Bioinformatic Analysis of the circRNA Expression in Migraine Patients.	hsa_circ_0012634	hsa_circRNA_100236	hsa_circ_TMEM59	TMEM59	Migraine 	MONDO:0005277	migraine disorder	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_100236 (hsa_circ_0012634) is down-regulated in migraine patient plasma and validated by qRT-PCR. The study does not report a specific mechanism, pathway, or downstream targets for this circRNA beyond differential expression."	0.4773
33178826	BioMed research international	2020	Differential Expression and Bioinformatic Analysis of the circRNA Expression in Migraine Patients.	hsa_circ_0003745	hsa_circRNA_102413	hsa_circ_PIP5K1C	PIP5K1C	Migraine 	MONDO:0005277	migraine disorder	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_102413 (hsa_circ_0003745) is down-regulated in migraine patient plasma and validated by qRT-PCR. It was included in GO/KEGG and ceRNA-network predictions and highlighted as a potential regulator of migraine pathology, with hypothesized links to PI3K/AKT-associated inflammatory processes (without direct mechanistic validation)."	0.5135
33178826	BioMed research international	2020	Differential Expression and Bioinformatic Analysis of the circRNA Expression in Migraine Patients.	hsa_circ_0039908	hsa_circRNA_101833	hsa_circ_DUS2	DUS2	Migraine 	MONDO:0005277	migraine disorder	dysregulated	Microarray	"hsa_circRNA_101833 (hsa_circ_0039908) shows conflicting direction between the abstract (reduced) and the reported qRT-PCR confirmation (upregulation), so it is treated as dysregulated. The study does not provide a specific mechanism or pathway for this circRNA."	0.429
33179443	Journal of cellular and molecular medicine	2020	CircFAT1 promotes hepatocellular carcinoma progression via miR-30a-5p/REEP3 pathway.		circFAT1	hsa_circ_FAT1	FAT1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circFAT1 is up-regulated in hepatocellular carcinoma tissues and cell lines and mainly localizes to the cytoplasm. It promotes HCC proliferation, invasion, EMT and xenograft tumor growth by acting as a ceRNA that sponges miR-30a-5p, thereby increasing REEP3 expression."	0.7631
33184989	Journal of cellular and molecular medicine	2020	Circ_0075829 facilitates the progression of pancreatic carcinoma by sponging miR-1287-5p and activating LAMTOR3 signalling.	hsa_circ_0075829	Circ_0075829 	hsa_circ_CASC15	CASC15	pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"circ_0075829 is up-regulated in pancreatic cancer tissues and cells and mainly localizes to the cytoplasm. It promotes pancreatic cancer proliferation, migration/invasion and in vivo growth/metastasis by sponging miR-1287-5p, thereby increasing LAMTOR3 and activating downstream ERK signaling."	0.8175
33190405	Molecular oncology	2021	"A novel circular RNA, hsa_circ_0030998 suppresses lung cancer tumorigenesis and Taxol resistance by sponging miR-558."	hsa_circ_0030998	circ_0030998 	hsa_circ_LAMP1	LAMP1	lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	"hsa_circ_0030998 (circ_0030998), derived from LAMP1 exon 3, is down-regulated in lung cancer tissues/cells and in Taxol-resistant cells. It functions mainly in the cytoplasm as a miR-558 sponge (AGO2-associated), thereby suppressing lung cancer cell proliferation, migration, invasion and reducing Taxol resistance, and its higher expression is associated with better patient survival."	0.8708
33192077	OncoTargets and therapy	2020	Circ_0110805 Knockdown Enhances Cisplatin Sensitivity and Inhibits Gastric Cancer Progression by miR-299-3p/ENDOPDI Axis.	hsa_circ_0110805	circ_0110805			gastric cancer	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_0110805 is up-regulated in cisplatin-resistant gastric cancer tissues and cells. Its knockdown increases cisplatin sensitivity and suppresses malignant behaviors by sponging miR-299-3p to reduce ENDOPDI expression, including in a xenograft model."	0.6536
33192092	Cancer management and research	2020	Effect of the Up-Regulation of Circular RNA Hsa_circ_0069767 Derived from C-KIT on the Biological Behavior of Multiple Myeloma Cells.	hsa_circ_0069767	circ_0069767 	hsa_circ_C-KIT		Multiple myeloma 	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR	"circ_0069767 (derived from C-KIT/KIT) is up-regulated in multiple myeloma bone marrow samples and higher levels predict better PFS/OS. Functionally, circ_0069767 suppresses MM cell viability/proliferation, migration and invasion while enhancing apoptosis, and mechanistically acts as a sponge for miR-636 to regulate K-RAS expression."	0.7646
33193637	Frontiers in genetics	2020	"Changing Expression Profiles of Messenger RNA, MicroRNA, Long Non-coding RNA, and Circular RNA Reveal the Key Regulators and Interaction Networks of Competing Endogenous RNA in Pulmonary Fibrosis."		circRNA1863			pulmonary fibrosis 	MONDO:0002771	pulmonary fibrosis	dysregulated	RNA-seq	"In a bleomycin-induced rat pulmonary fibrosis model, circRNA1863 was identified as differentially expressed and was bioinformatically associated with negative regulation of EGFR signaling. Its specific downstream miRNA/mRNA mechanism was not experimentally validated in this study."	0.31
33193637	Frontiers in genetics	2020	"Changing Expression Profiles of Messenger RNA, MicroRNA, Long Non-coding RNA, and Circular RNA Reveal the Key Regulators and Interaction Networks of Competing Endogenous RNA in Pulmonary Fibrosis."		circRNA3902			pulmonary fibrosis 	MONDO:0002771	pulmonary fibrosis	dysregulated	RNA-seq	circRNA3902 was reported as a differentially expressed circRNA in a bleomycin-induced rat pulmonary fibrosis model and was linked by enrichment analysis to negative regulation of EGFR signaling. No circRNA-specific wet-lab validation was provided.	0.31
33193637	Frontiers in genetics	2020	"Changing Expression Profiles of Messenger RNA, MicroRNA, Long Non-coding RNA, and Circular RNA Reveal the Key Regulators and Interaction Networks of Competing Endogenous RNA in Pulmonary Fibrosis."		circRNA822			pulmonary fibrosis 	MONDO:0002771	pulmonary fibrosis	dysregulated	RNA-seq	circRNA822 was identified as a differentially expressed circRNA in bleomycin-induced rat pulmonary fibrosis lungs and was associated (by GO enrichment) with negative regulation of EGFR signaling and positive regulation of the JNK cascade. The paper did not report circRNA822-specific qRT-PCR or mechanistic validation.	0.31
33193637	Frontiers in genetics	2020	"Changing Expression Profiles of Messenger RNA, MicroRNA, Long Non-coding RNA, and Circular RNA Reveal the Key Regulators and Interaction Networks of Competing Endogenous RNA in Pulmonary Fibrosis."		circRNA178			pulmonary fibrosis 	MONDO:0002771	pulmonary fibrosis	dysregulated	RNA-seq	circRNA178 was identified as differentially expressed in a rat bleomycin-induced pulmonary fibrosis model and was linked via GO enrichment to negative regulation of EGFR signaling. No direct experimental validation for circRNA178 was reported.	0.31
33193637	Frontiers in genetics	2020	"Changing Expression Profiles of Messenger RNA, MicroRNA, Long Non-coding RNA, and Circular RNA Reveal the Key Regulators and Interaction Networks of Competing Endogenous RNA in Pulmonary Fibrosis."		circRNA1388			pulmonary fibrosis 	MONDO:0002771	pulmonary fibrosis	dysregulated	RNA-seq	circRNA1388 was identified as differentially expressed in bleomycin-induced rat pulmonary fibrosis and was bioinformatically linked to regulation of the TGF-beta signaling pathway. No circRNA1388-specific experimental validation was reported.	0.31
33193637	Frontiers in genetics	2020	"Changing Expression Profiles of Messenger RNA, MicroRNA, Long Non-coding RNA, and Circular RNA Reveal the Key Regulators and Interaction Networks of Competing Endogenous RNA in Pulmonary Fibrosis."		circRNA1765			pulmonary fibrosis 	MONDO:0002771	pulmonary fibrosis	dysregulated	RNA-seq	circRNA1765 was identified as a differentially expressed circRNA in rat pulmonary fibrosis and was linked to regulation of TGF-beta signaling and positive regulation of the JNK cascade based on GO enrichment. The study did not provide circRNA1765-specific experimental validation.	0.31
33193637	Frontiers in genetics	2020	"Changing Expression Profiles of Messenger RNA, MicroRNA, Long Non-coding RNA, and Circular RNA Reveal the Key Regulators and Interaction Networks of Competing Endogenous RNA in Pulmonary Fibrosis."		circRNA243			pulmonary fibrosis 	MONDO:0002771	pulmonary fibrosis	dysregulated	RNA-seq	circRNA243 was identified as differentially expressed in rat pulmonary fibrosis and was linked by enrichment analysis to regulation of the TGF-beta signaling pathway. No direct validation for circRNA243 was reported.	0.31
33193637	Frontiers in genetics	2020	"Changing Expression Profiles of Messenger RNA, MicroRNA, Long Non-coding RNA, and Circular RNA Reveal the Key Regulators and Interaction Networks of Competing Endogenous RNA in Pulmonary Fibrosis."		circRNA2783			pulmonary fibrosis 	MONDO:0002771	pulmonary fibrosis	dysregulated	RNA-seq	circRNA2783 was reported as differentially expressed in rat pulmonary fibrosis and bioinformatically associated with TGF-beta signaling regulation. No circRNA2783-specific qRT-PCR or functional assays were described.	0.31
33193637	Frontiers in genetics	2020	"Changing Expression Profiles of Messenger RNA, MicroRNA, Long Non-coding RNA, and Circular RNA Reveal the Key Regulators and Interaction Networks of Competing Endogenous RNA in Pulmonary Fibrosis."		circRNA437			pulmonary fibrosis 	MONDO:0002771	pulmonary fibrosis	dysregulated	RNA-seq	circRNA437 was identified as differentially expressed in a rat pulmonary fibrosis model and was linked by enrichment analysis to TGF-beta signaling regulation. The study did not report circRNA437-specific experimental validation.	0.31
33193637	Frontiers in genetics	2020	"Changing Expression Profiles of Messenger RNA, MicroRNA, Long Non-coding RNA, and Circular RNA Reveal the Key Regulators and Interaction Networks of Competing Endogenous RNA in Pulmonary Fibrosis."		circRNA439			pulmonary fibrosis 	MONDO:0002771	pulmonary fibrosis	dysregulated	RNA-seq	circRNA439 was identified as differentially expressed in rat pulmonary fibrosis and was linked to regulation of TGF-beta signaling based on enrichment analysis. No circRNA439-specific functional experiments were reported.	0.31
33193637	Frontiers in genetics	2020	"Changing Expression Profiles of Messenger RNA, MicroRNA, Long Non-coding RNA, and Circular RNA Reveal the Key Regulators and Interaction Networks of Competing Endogenous RNA in Pulmonary Fibrosis."		circRNA988			pulmonary fibrosis 	MONDO:0002771	pulmonary fibrosis	dysregulated	RNA-seq	circRNA988 was identified as differentially expressed in bleomycin-induced rat pulmonary fibrosis and was associated by enrichment analysis with regulation of TGF-beta signaling. No circRNA988-specific experimental validation was described.	0.31
33193637	Frontiers in genetics	2020	"Changing Expression Profiles of Messenger RNA, MicroRNA, Long Non-coding RNA, and Circular RNA Reveal the Key Regulators and Interaction Networks of Competing Endogenous RNA in Pulmonary Fibrosis."		circRNA1178			pulmonary fibrosis 	MONDO:0002771	pulmonary fibrosis	dysregulated	RNA-seq	circRNA1178 was identified as differentially expressed in rat pulmonary fibrosis and was linked via GO enrichment to positive regulation of the JNK cascade (MAPK-related). No circRNA1178-specific validation experiments were reported.	0.31
33193637	Frontiers in genetics	2020	"Changing Expression Profiles of Messenger RNA, MicroRNA, Long Non-coding RNA, and Circular RNA Reveal the Key Regulators and Interaction Networks of Competing Endogenous RNA in Pulmonary Fibrosis."		circRNA1355			pulmonary fibrosis 	MONDO:0002771	pulmonary fibrosis	dysregulated	RNA-seq	circRNA1355 was identified as differentially expressed in rat pulmonary fibrosis and linked by GO enrichment to positive regulation of the JNK cascade. The paper did not include circRNA1355-specific experimental validation.	0.31
33193637	Frontiers in genetics	2020	"Changing Expression Profiles of Messenger RNA, MicroRNA, Long Non-coding RNA, and Circular RNA Reveal the Key Regulators and Interaction Networks of Competing Endogenous RNA in Pulmonary Fibrosis."		circRNA1635			pulmonary fibrosis 	MONDO:0002771	pulmonary fibrosis	dysregulated	RNA-seq	circRNA1635 was reported as differentially expressed in bleomycin-induced rat pulmonary fibrosis and associated with positive regulation of the JNK cascade by GO enrichment. No circRNA1635-specific validation was provided.	0.31
33193637	Frontiers in genetics	2020	"Changing Expression Profiles of Messenger RNA, MicroRNA, Long Non-coding RNA, and Circular RNA Reveal the Key Regulators and Interaction Networks of Competing Endogenous RNA in Pulmonary Fibrosis."		circRNA170			pulmonary fibrosis 	MONDO:0002771	pulmonary fibrosis	dysregulated	RNA-seq	circRNA170 was identified as a differentially expressed circRNA in rat pulmonary fibrosis and was associated with positive regulation of the JNK cascade by GO enrichment. No circRNA170-specific experimental validation was performed.	0.31
33193637	Frontiers in genetics	2020	"Changing Expression Profiles of Messenger RNA, MicroRNA, Long Non-coding RNA, and Circular RNA Reveal the Key Regulators and Interaction Networks of Competing Endogenous RNA in Pulmonary Fibrosis."		circRNA3100			pulmonary fibrosis 	MONDO:0002771	pulmonary fibrosis	dysregulated	RNA-seq	circRNA3100 was reported as differentially expressed in rat pulmonary fibrosis and associated with positive regulation of the JNK cascade by GO enrichment. No circRNA3100-specific experimental validation was included.	0.31
33193848	Oncology letters	2020	Hypoxia-induced circular RNA hsa_circ_0008450 accelerates hepatocellular cancer progression via the miR-431/AKAP1 axis.	hsa_circ_0008450	circ_0008450	hsa_circ_CMTM3	CMTM3	hepatocellular cancer 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"hsa_circ_0008450 (circ_0008450), derived from CMTM3, is up-regulated in HCC tissues/serum and in hypoxia-treated HCC cells. It promotes hypoxia-driven malignant phenotypes (higher viability and glycolysis, lower apoptosis) and tumor growth by sponging miR-431 to increase AKAP1 expression, forming a circ_0008450/miR-431/AKAP1 axis with diagnostic potential."	0.8158
33193877	Journal of Cancer	2020	Circular RNA microarray expression profile and potential function of circ0005875 in clear cell renal cell carcinoma.	hsa_circ_0005875				clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR; Microarray	"In ccRCC, hsa_circ_0005875 is up-regulated in tumor tissues and most renal carcinoma cell lines. Its overexpression promotes proliferation, migration, and invasion, and it may function as a miR-145-5p sponge to modulate the miR-145-5p/ZEB2 axis, suggesting potential biomarker value."	0.7291
33195183	Frontiers in cell and developmental biology	2020	"Hsa_circ_0088233 Alleviates Proliferation, Migration, and Invasion of Prostate Cancer by Targeting hsa-miR-185-3p."	hsa_circ_0088233	circ_0088233			prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	"circ_0088233 is up-regulated in prostate cancer tissues and cell lines and correlates with TNM stage. It promotes prostate cancer cell proliferation, migration, invasion, cell cycle progression and tumor growth while inhibiting apoptosis, mainly by sponging miR-185-3p and affecting downstream targets including E2F1 and WNT2B."	0.8122
33195225	Frontiers in cell and developmental biology	2020	CircCOG8 Downregulation Contributes to the Compression-Induced Intervertebral Disk Degeneration by Targeting miR-182-5p and FOXO3.	hsa_circ_0040060	circCOG8	hsa_circ_COG8	COG8	intervertebral disk degeneration 	MONDO:0011385	intervertebral disk degenerative disorder	down-regulated	RT-qPCR; Microarray	"circCOG8 is down-regulated under compression in human nucleus pulposus cells and functions protectively by reducing apoptosis, ROS accumulation, and ECM degradation. Mechanistically, it acts as a ceRNA sponge for miR-182-5p to relieve repression of FOXO3, thereby attenuating compression-induced IDD progression (including in an ex vivo rat IVD model)."	0.7922
33195232	Frontiers in cell and developmental biology	2020	Promotion of Bronchopulmonary Dysplasia Progression Using Circular RNA circabcc4 via Facilitating PLA2G6 Expression by Sequestering miR-663a.	hsa_circ_0030605	circABCC4	hsa_circ_ABCC4	ABCC4	bronchopulmonary dysplasia 	MONDO:0019091	bronchopulmonary dysplasia	up-regulated	RT-qPCR; Microarray	"circABCC4 is up-regulated in BPD (patient peripheral blood and hyperoxia models) and mainly localizes to the cytoplasm. It promotes BPD progression by acting as a ceRNA that sponges miR-663a, relieving repression of PLA2G6, thereby enhancing apoptosis and inhibiting proliferation."	0.8289
33195693	BioMed research international	2020	"Circular RNA circ-CCAC1 Facilitates Adrenocortical Carcinoma Cell Proliferation, Migration, and Invasion through Regulating the miR-514a-5p/C22orf46 Axis."	hsa_circ_0043469	circ-CCAC1 	hsa_circ_ERBB2	ERBB2	Adrenocortical carcinoma 	MONDO:0006639	adrenal cortex carcinoma	up-regulated	RT-qPCR	"circ-CCAC1 is up-regulated in ACC tissues and cell lines and is associated with worse overall survival. Functionally, circ-CCAC1 promotes ACC cell proliferation, migration, and invasion and inhibits apoptosis by acting as a ceRNA that sponges miR-514a-5p to upregulate C22orf46."	0.8025
33196759	Genetics and molecular biology	2020	A comparison of mRNA and circRNA expression between squamous cell carcinoma and adenocarcinoma of the lungs.		hsa_circ_027570			non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	dysregulated	RNA-seq	"hsa_circ_027570 is differentially expressed between LUAD and LUSC and was highlighted as a key node in a predicted ceRNA network. It is predicted to bind hsa-miR-103a-3p, suggesting a potential miRNA-sponge role, but no experimental functional validation was reported."	0.1768
33196759	Genetics and molecular biology	2020	A comparison of mRNA and circRNA expression between squamous cell carcinoma and adenocarcinoma of the lungs.		hsa_circ_006089			non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	dysregulated	RNA-seq	"hsa_circ_006089 is differentially expressed between LUAD and LUSC and appears as a hub circRNA in the predicted miRNA_circRNA/ceRNA networks. It is predicted to bind hsa-miR-103a-3p, implying a possible ceRNA role, but no wet-lab validation was provided."	0.1768
33196759	Genetics and molecular biology	2020	A comparison of mRNA and circRNA expression between squamous cell carcinoma and adenocarcinoma of the lungs.		hsa-circ_035997			non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	dysregulated	RNA-seq	"hsa-circ_035997 is differentially expressed between LUAD and LUSC and was identified as a key circRNA node in the computational ceRNA analysis. It is predicted to bind miR-141-3p, suggesting a potential miRNA-sponge mechanism, but experimental validation was not performed."	0.1768
33198772	Journal of experimental & clinical cancer research : CR	2020	Circular RNA MCTP2 inhibits cisplatin resistance in gastric cancer by miR-99a-5p-mediated induction of MTMR3 expression.	hsa_circ_0000657	circMCTP2	hsa_circ_MCTP2	MCTP2	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; RNA-seq	"circMCTP2 is down-regulated in cisplatin-resistant gastric cancer cells/tissues. Functionally, circMCTP2 suppresses cisplatin resistance by inhibiting proliferation, promoting apoptosis, and reducing autophagy. Mechanistically, it acts as a ceRNA that sponges miR-99a-5p to upregulate MTMR3."	0.8905
33200221	Oncology reports	2021	Microarray expression profile analysis of circular RNAs and their potential regulatory role in bladder carcinoma.		hsa_circRNA_100876 	hsa_circ_CBX4	CBX4	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_100876 is up-regulated in bladder cancer tissues and promotes malignant behavior by enhancing proliferation. Mechanistically, it functions as a ceRNA by sponging miR-136-5p to increase CBX4 expression, and high expression is associated with advanced stage, lymphatic metastasis, and poor overall survival."	0.8063
33200535	Journal of cellular and molecular medicine	2022	circ-AKT3 aggravates renal ischaemia-reperfusion injury via regulating miR-144-5p /Wnt/beta-catenin pathway and oxidative stress.		circ-AKT3 	rno_circ_AKT3	AKT3	renal ischaemia-reperfusion injury 	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR; ISH	"circ-AKT3 is up-regulated in rat renal I/R injury and predominantly localizes to the cytoplasm. It aggravates renal I/R injury by sponging miR-144-5p, thereby promoting apoptosis, activating Wnt/beta-catenin signaling, and increasing oxidative stress; miR-144-5p mimic reverses these effects."	0.6867
33204164	Cancer management and research	2020	CircSEC31A Promotes the Malignant Progression of Non-Small Cell Lung Cancer Through Regulating SEC31A Expression via Sponging miR-376a.	hsa_circ_0001421	circSEC31A 	hsa_circ_SEC31A	SEC31A	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circSEC31A is up-regulated in NSCLC tissues and cell lines and promotes malignant phenotypes (migration, invasion, glycolysis, and tumor growth) while inhibiting apoptosis. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-376a, thereby relieving miR-376a-mediated repression of SEC31A."	0.762
33205602	Journal of cellular and molecular medicine	2021	Circular RNA circANKRD36 regulates Casz1 by targeting miR-599 to prevent osteoarthritis chondrocyte apoptosis and inflammation.		circANKRD36	hsa_circ_ANKRD36	ANKRD36	Osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR; RNA-seq	"circANKRD36 is down-regulated in osteoarthritis cartilage and IL-1beta-treated human chondrocytes. It suppresses IL-1beta-induced chondrocyte apoptosis and inflammatory cytokine production by acting as a miR-599 sponge, thereby relieving miR-599-mediated repression of Casz1."	0.8278
33207694	Cells	2020	SRRM4 Expands the Repertoire of Circular RNAs by Regulating Microexon Inclusion.		ME-circEIF4G3 	hsa_circ_EIF4G3	EIF4G3	gliomas 	MONDO:0021042	glioma	down-regulated	RT-qPCR; RNA-seq	"ME-circEIF4G3 (a microexon-containing circRNA from EIF4G3) is biogenesis-controlled by the splicing factor SRRM4. It shows reduced abundance in matched GBM tumor versus healthy brain tissue in an example patient, and was experimentally validated by RT-PCR and Sanger sequencing across the backsplice junction."	0.6926
33207694	Cells	2020	SRRM4 Expands the Repertoire of Circular RNAs by Regulating Microexon Inclusion.		circLRBA	hsa_circ_LRBA	LRBA	gliomas 	MONDO:0021042	glioma	unknown	RT-qPCR; RNA-seq	"circLRBA is an SRRM4-driven circRNA whose presence in HEK293 cells depends on SRRM4 overexpression, indicating SRRM4 can promote its biogenesis. The study does not report a specific disease-associated expression change or downstream functional mechanism for circLRBA in gliomas/GBM."	0.5598
33207694	Cells	2020	SRRM4 Expands the Repertoire of Circular RNAs by Regulating Microexon Inclusion.		circSETDB2	hsa_circ_SETDB2	SETDB2	gliomas 	MONDO:0021042	glioma	unknown	RT-qPCR; RNA-seq	"circSETDB2 is an SRRM4-driven circRNA validated to be absent in HEK293 empty-vector cells but present after SRRM4 overexpression, supporting SRRM4-dependent circRNA biogenesis. The study does not provide a specific disease-direction expression change or functional/clinical mechanism for circSETDB2 in gliomas/GBM."	0.5598
33207694	Cells	2020	SRRM4 Expands the Repertoire of Circular RNAs by Regulating Microexon Inclusion.		ME-circDPY19L1	hsa_circ_DPY19L1	DPY19L1	gliomas 	MONDO:0021042	glioma	unknown	RT-qPCR	"ME-circDPY19L1 is a Hyb-identified microexon-containing circRNA whose existence was supported by RT-PCR and Sanger sequencing in tumor samples. The study does not report its differential expression direction, downstream targets, or functional role in gliomas/GBM."	0.5531
33209054	International journal of general medicine	2020	Clinical Significance of Has_circ_0060937 in Bone Metastasis of NSCLC.	hsa_circ_0060937		hsa_circ_CYP24A1	CYP24A1	non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"has_circ_0060937 (derived from CYP24A1) is up-regulated in NSCLC tissues and is highest in NSCLC with bone metastasis, including elevated serum levels across bone-metastasis grades. Functionally, its knockdown suppresses proliferation and invasion in NSCLC bone-metastasis cells, and high expression is associated with poorer survival, supporting its potential as a biomarker for NSCLC bone metastasis."	0.6949
33210454	Journal of cellular and molecular medicine	2022	Circular RNA circ_0008305 aggravates hepatocellular carcinoma growth through binding to miR-186 and inducing TMED2.	hsa_circ_0008305	circ_0008305			hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0008305 is up-regulated in HCC tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion and tumour growth). It functions as a ceRNA by sponging miR-186 to relieve repression of TMED2, thereby enhancing HCC progression."	0.7554
33217846	Medicine	2020	Correlation between serum circRNA and thyroid micropapillary carcinoma with cervical lymph node metastasis.		hsa_circRNA_000121  			papillary thyroid microcarcinoma 	MONDO:0011368	papillary thyroid Microcarcinoma	up-regulated	RT-qPCR; Microarray	"Serum hsa_circRNA_000121 is up-regulated in PTMC (L) versus non-invasive PTMC in female patients. It is predicted to bind miR-146b-3p and may be involved in metastatic/invasive behavior, with a proposed circRNA000121/miR-146b-3p/NF2 axis."	0.4032
33217846	Medicine	2020	Correlation between serum circRNA and thyroid micropapillary carcinoma with cervical lymph node metastasis.		hsa_circRNA_000466 			papillary thyroid microcarcinoma 	MONDO:0011368	papillary thyroid Microcarcinoma	up-regulated	RT-qPCR; Microarray	"Serum hsa_circRNA_000466 is up-regulated in PTMC (L) versus non-invasive PTMC in female patients. It is predicted to interact with several miRNAs (including miR-485-5p), suggesting a potential ceRNA-related role in PTMC lymph node metastasis."	0.4032
33217846	Medicine	2020	Correlation between serum circRNA and thyroid micropapillary carcinoma with cervical lymph node metastasis.		hsa_circRNA_001059 			papillary thyroid microcarcinoma 	MONDO:0011368	papillary thyroid Microcarcinoma	up-regulated	RT-qPCR; Microarray	"Serum hsa_circRNA_001059 is up-regulated in PTMC (L) versus non-invasive PTMC in female patients, supported by microarray and RT-qPCR. It is bioinformatically predicted to bind multiple miRNAs, suggesting a potential ceRNA-related involvement in PTMC lymph node metastasis."	0.4032
33217846	Medicine	2020	Correlation between serum circRNA and thyroid micropapillary carcinoma with cervical lymph node metastasis.		hsa_circRNA_051239 			papillary thyroid microcarcinoma 	MONDO:0011368	papillary thyroid Microcarcinoma	up-regulated	RT-qPCR; Microarray	"Serum hsa_circRNA_051239 is up-regulated in PTMC (L) versus non-invasive PTMC in female patients. It is predicted to bind miR-574-5p and other miRNAs, implying a potential ceRNA-related association with metastatic processes."	0.4032
33217846	Medicine	2020	Correlation between serum circRNA and thyroid micropapillary carcinoma with cervical lymph node metastasis.		hsa_circRNA_102116 			papillary thyroid microcarcinoma 	MONDO:0011368	papillary thyroid Microcarcinoma	up-regulated	RT-qPCR; Microarray	"Serum hsa_circRNA_102116 is up-regulated in PTMC (L) versus non-invasive PTMC in female patients, validated by RT-qPCR. It is predicted to bind multiple miRNAs, consistent with a potential ceRNA-related role in lymph node metastasis."	0.4032
33217846	Medicine	2020	Correlation between serum circRNA and thyroid micropapillary carcinoma with cervical lymph node metastasis.		hsa_circRNA_001729 			papillary thyroid microcarcinoma 	MONDO:0011368	papillary thyroid Microcarcinoma	down-regulated	RT-qPCR; Microarray	"Serum hsa_circRNA_001729 is down-regulated in PTMC (L) versus non-invasive PTMC in female patients. It is predicted to interact with miR-363-3p (and other miRNAs) and is discussed as potentially contributing to cervical lymph node metastasis via miRNA-mediated downstream pathways, though this is speculative in the paper."	0.4032
33217846	Medicine	2020	Correlation between serum circRNA and thyroid micropapillary carcinoma with cervical lymph node metastasis.		hsa_circRNA_004183 			papillary thyroid microcarcinoma 	MONDO:0011368	papillary thyroid Microcarcinoma	down-regulated	RT-qPCR; Microarray	"Serum hsa_circRNA_004183 is down-regulated in PTMC (L) versus non-invasive PTMC in female patients, validated by RT-qPCR. It is predicted to bind several miRNAs, suggesting possible ceRNA-related involvement in lymph node metastasis, though no specific downstream target is validated."	0.4032
33217846	Medicine	2020	Correlation between serum circRNA and thyroid micropapillary carcinoma with cervical lymph node metastasis.		hsa_circRNA_102051 			papillary thyroid microcarcinoma 	MONDO:0011368	papillary thyroid Microcarcinoma	down-regulated	RT-qPCR; Microarray	"Serum hsa_circRNA_102051 is down-regulated in PTMC (L) versus non-invasive PTMC in female patients and validated by RT-qPCR. It is predicted to bind several miRNAs, consistent with a putative ceRNA association with lymph node metastasis."	0.4032
33217846	Medicine	2020	Correlation between serum circRNA and thyroid micropapillary carcinoma with cervical lymph node metastasis.		hsa_circRNA_404686 			papillary thyroid microcarcinoma 	MONDO:0011368	papillary thyroid Microcarcinoma	down-regulated	RT-qPCR; Microarray	"Serum hsa_circRNA_404686 is differentially expressed between PTMC with cervical lymph node metastasis (PTMC (L)) and non-invasive PTMC, supported by microarray and RT-qPCR (including extended validation). The study constructed a predicted circRNA_miRNA_mRNA network for this circRNA and suggests it may act via miRNA sponging (e.g., miR-214-3p). The authors propose it as a potential circulating diagnostic marker for PTMC (L) in females."	0.4032
33217846	Medicine	2020	Correlation between serum circRNA and thyroid micropapillary carcinoma with cervical lymph node metastasis.		hsa_circRNA_405571  			papillary thyroid microcarcinoma 	MONDO:0011368	papillary thyroid Microcarcinoma	down-regulated	RT-qPCR; Microarray	"Serum hsa_circRNA_405571 is down-regulated in PTMC (L) versus non-invasive PTMC in female patients and validated by RT-qPCR. It is predicted to bind multiple miRNAs, suggesting potential ceRNA-related involvement in lymph node metastasis, without validated downstream targets."	0.4032
33219594	Journal of cellular and molecular medicine	2022	CircSAMD4A aggravates H/R-induced cardiomyocyte apoptosis and inflammatory response by sponging miR-138-5p.		circSAMD4A	mmu_circ_SAMD4A	SAMD4A	acute myocardial infarction 	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR	"circSAMD4A is up-regulated in AMI mouse hearts and H/R-treated H9C2 cells. Its inhibition reduces cardiomyocyte apoptosis and inflammatory cytokine production, while mechanistically it sponges miR-138-5p to promote H/R-induced myocardial injury in vitro and in vivo."	0.5634
33219594	Journal of cellular and molecular medicine	2022	CircSAMD4A aggravates H/R-induced cardiomyocyte apoptosis and inflammatory response by sponging miR-138-5p.		circSAMD4A	rno_circ_SAMD4A	SAMD4A	acute myocardial infarction 	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR	"circSAMD4A is up-regulated in AMI mouse hearts and H/R-treated H9C2 cells. Its inhibition reduces cardiomyocyte apoptosis and inflammatory cytokine production, while mechanistically it sponges miR-138-5p to promote H/R-induced myocardial injury in vitro and in vivo."	0.5634
33221744	Aging	2020	Hsa_circ_0048179 attenuates free fatty acid-induced steatosis via hsa_circ_0048179/miR-188-3p/GPX4 signaling.	hsa_circ_0048179				non-alcoholic fatty liver disease 	MONDO:0013209	metabolic dysfunction-associated steatotic liver disease	down-regulated	RT-qPCR	"In an oleate/palmitate-induced in vitro NAFLD/steatosis model in HepG2 cells, hsa_circ_0048179 is down-regulated. Its overexpression alleviates lipid accumulation and related oxidative/mitochondrial injury by sponging miR-188-3p and thereby increasing GPX4 expression."	0.5997
33221765	Aging	2020	Comprehensive circular RNA expression profiling constructs a ceRNA network and identifies hsa_circ_0000673 as a novel oncogene in distal cholangiocarcinoma.	hsa_circ_0000673		hsa_circ_RSL1D1	RSL1D1	distal cholangiocarcinoma 	MONDO:0019087	cholangiocarcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000673 is up-regulated in distal cholangiocarcinoma and shows diagnostic potential (AUC 0.85). Functionally, its knockdown inhibits CCA cell proliferation, migration, and invasion, supporting an oncogenic role. Mechanistically, it binds miR-548b-3p and is proposed to affect CCNB1 within a ceRNA network."	0.8162
33221765	Aging	2020	Comprehensive circular RNA expression profiling constructs a ceRNA network and identifies hsa_circ_0000673 as a novel oncogene in distal cholangiocarcinoma.	hsa_circ_0060144				distal cholangiocarcinoma 	MONDO:0019087	cholangiocarcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0060144 is up-regulated in dCCA and was incorporated into a circRNA-miRNA-mRNA network. Its binding to miR-616-3p/miR-629-3p/miR-643 was supported by luciferase assays, and a potential axis involving miR-616-3p/NEK2 was discussed."	0.7164
33221765	Aging	2020	Comprehensive circular RNA expression profiling constructs a ceRNA network and identifies hsa_circ_0000673 as a novel oncogene in distal cholangiocarcinoma.	hsa_circ_0008274				distal cholangiocarcinoma 	MONDO:0019087	cholangiocarcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0008274 is up-regulated in dCCA and included in a ceRNA network. Its binding to miR-526b-5p was validated by luciferase reporter assay, but downstream targets and functional effects were not experimentally characterized in this paper."	0.7164
33221765	Aging	2020	Comprehensive circular RNA expression profiling constructs a ceRNA network and identifies hsa_circ_0000673 as a novel oncogene in distal cholangiocarcinoma.	hsa_circ_0139402				distal cholangiocarcinoma 	MONDO:0019087	cholangiocarcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0139402 is down-regulated in dCCA tissues and was included in a ceRNA network. Its binding to miR-885-3p was validated by luciferase reporter assay, but no direct functional experiments were reported for this circRNA."	0.7164
33221765	Aging	2020	Comprehensive circular RNA expression profiling constructs a ceRNA network and identifies hsa_circ_0000673 as a novel oncogene in distal cholangiocarcinoma.	hsa_circ_0001714				distal cholangiocarcinoma 	MONDO:0019087	cholangiocarcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0001714 is down-regulated in dCCA tissues and included in a ceRNA network. Its binding to miR-766-5p was validated by luciferase reporter assay, but downstream targets and functional impacts were not directly tested for this circRNA in this study."	0.7164
33221767	Aging	2020	Hsa_circ_0001869 promotes NSCLC progression via sponging miR-638 and enhancing FOSL2 expression.	hsa_circ_0001869		hsa_circ_ZCCHC6	ZCCHC6	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; ISH	"hsa_circ_0001869 is up-regulated in NSCLC tissues and cell lines and acts as an oncogenic circRNA. It promotes NSCLC proliferation, migration, invasion and in vivo tumor growth by sponging miR-638 and thereby enhancing FOSL2 expression, and high expression is associated with poor overall survival."	0.7631
33222692	Molecular cancer	2020	N6-methyladenosine-modified CircRNA-SORE sustains sorafenib resistance in hepatocellular carcinoma by regulating beta-catenin signaling.	hsa_circ_0087293		hsa_circ_TLE4	TLE4	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circRNA-SORE is up-regulated in sorafenib-resistant HCC and is required to maintain resistance by suppressing sorafenib-induced apoptosis. It acts as a ceRNA that sponges miR-103a-2-5p and miR-660-3p, thereby activating Wnt2b/beta-catenin signaling. Its elevated abundance in resistant cells is promoted by m6A-dependent stabilization, and targeting it in vivo enhances sorafenib efficacy."	0.8729
33222697	Journal of experimental & clinical cancer research : CR	2020	A novel circular RNA circ-LRIG3 facilitates the malignant progression of hepatocellular carcinoma by modulating the EZH2/STAT3 signaling.	hsa_circ_0027345		hsa_circ_LRIG3	LRIG3	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ-LRIG3 (hsa_circ_0027345) is upregulated in HCC tissues/cells/plasma and functions as an oncogenic nuclear circRNA. It scaffolds EZH2 and STAT3 to enhance STAT3 methylation/phosphorylation and activate STAT3 signaling, and activated STAT3 increases circ-LRIG3 transcription to form a positive feedback loop, promoting proliferation, invasion and metastasis and inhibiting apoptosis. Clinically, high circ-LRIG3 indicates poor prognosis and plasma circ-LRIG3 shows diagnostic potential for HCC."	0.9014
33223511	Aging	2020	Construction of circRNA-based ceRNA network to reveal the role of circRNAs in the progression and prognosis of metastatic clear cell renal cell carcinoma.	hsa_circ_0002286		hsa_circ_NTNG1	NTNG1	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0002286 is down-regulated in ccRCC tissues and shows a tumor-suppressive association. The study proposes a ceRNA axis in which hsa_circ_0002286 interacts with miR-222-5p to affect TRIM2, potentially inhibiting ccRCC metastasis and progression."	0.4032
33223511	Aging	2020	Construction of circRNA-based ceRNA network to reveal the role of circRNAs in the progression and prognosis of metastatic clear cell renal cell carcinoma.	hsa_circ_0000512		hsa_circ_RPPH1	RPPH1	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	down-regulated	RT-qPCR; Microarray	hsa_circ_0000512 is down-regulated in ccRCC tissues based on microarray screening and RT-qPCR validation. The study did not further define its specific miRNA/mRNA regulatory axis or functional mechanism.	0.4032
33223511	Aging	2020	Construction of circRNA-based ceRNA network to reveal the role of circRNAs in the progression and prognosis of metastatic clear cell renal cell carcinoma.	hsa_circ_0003596		hsa_circ_COL5A1	COL5A1	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	unknown	RT-qPCR; Microarray	hsa_circ_0003596 shows differential expression between ccRCC tumor cell lines and 293T cells and is part of the circRNA set screened by microarray/bioinformatics. The paper does not report a specific downstream miRNA/mRNA axis or functional role for this circRNA.	0.2465
33223511	Aging	2020	Construction of circRNA-based ceRNA network to reveal the role of circRNAs in the progression and prognosis of metastatic clear cell renal cell carcinoma.	hsa_circ_0035436		hsa_circ_CGNL1	CGNL1	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	unknown	RT-qPCR; Microarray	hsa_circ_0035436 is differentially expressed between ccRCC tumor cell lines and 293T cells in this study. No specific mechanistic axis or functional characterization is reported for this circRNA.	0.2465
33223849	Cancer management and research	2020	CircPVT1 Promoted the Progression of Breast Cancer by Regulating MiR-29a-3p-Mediated AGR2-HIF-1alpha Pathway.		circPVT1	hsa_circ_PVT1	PVT1	Breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circPVT1 is upregulated in breast cancer tissues/cells and promotes proliferation, migration, invasion and tumor growth while inhibiting apoptosis. Mechanistically, it functions as a ceRNA sponge for miR-29a-3p, thereby increasing AGR2 and HIF-1alpha expression via the miR-29a-3p/AGR2/HIF-1alpha axis."	0.7416
33225938	Molecular cancer	2020	The circular RNA circ-ERBIN promotes growth and metastasis of colorectal cancer by miR-125a-5p and miR-138-5p/4EBP-1 mediated cap-independent HIF-1alpha translation.	hsa_circ_0001492	circ-ERBIN 	hsa_circ_ERBIN	ERBIN	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ-ERBIN is up-regulated in colorectal cancer and promotes proliferation, migration/invasion, angiogenesis, and metastasis. It functions as a ceRNA sponging miR-125a-5p and miR-138-5p to increase 4EBP-1, thereby enhancing cap-independent translation of HIF-1alpha and activating HIF-1 signaling."	0.8635
33230102	Cell death & disease	2020	Exosomal circ_DLGAP4 promotes diabetic kidney disease progression by sponging miR-143 and targeting ERBB3/NF-kappaB/MMP-2 axis.		circ_DLGAP4 	rno_circ_DLGAP4	DLGAP4	diabetic kidney disease 	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"Exosomal circ_DLGAP4 is up-regulated in DKD (patient serum, HG-treated mesangial cells, and DKD rats). It promotes mesangial-cell proliferation and fibrosis by sponging miR-143, thereby increasing ERBB3 and activating the NF-kappaB/MMP-2 axis, which accelerates DKD progression in vivo."	0.8171
33230102	Cell death & disease	2020	Exosomal circ_DLGAP4 promotes diabetic kidney disease progression by sponging miR-143 and targeting ERBB3/NF-kappaB/MMP-2 axis.		circ_DLGAP4 	hsa_circ_DLGAP4	DLGAP4	diabetic kidney disease 	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"Exosomal circ_DLGAP4 is up-regulated in DKD (patient serum, HG-treated mesangial cells, and DKD rats). It promotes mesangial-cell proliferation and fibrosis by sponging miR-143, thereby increasing ERBB3 and activating the NF-kappaB/MMP-2 axis, which accelerates DKD progression in vivo."	0.8171
33230434	Molecular therapy. Nucleic acids	2020	Circular RNA circTMEM45A Acts as the Sponge of MicroRNA-665 to Promote Hepatocellular Carcinoma Progression.	hsa_circ_0066659	circTMEM45A	hsa_circ_TMEM45A	TMEM45A	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circTMEM45A (hsa_circ_0066659), derived from TMEM45A, is up-regulated in HCC tissues, HCC cell lines, and serum exosomes from HCC patients. It promotes HCC malignant phenotypes and xenograft tumor growth mainly by acting as a cytoplasmic ceRNA that sponges miR-665, thereby upregulating IGF2, and its high expression is associated with poor overall survival and diagnostic potential."	0.8824
33230436	Molecular therapy. Nucleic acids	2020	Circular RNA circCUL3 Accelerates the Warburg Effect Progression of Gastric Cancer through Regulating the STAT3/HK2 Axis.	hsa_circ_0008309	circCUL3	hsa_circ_CUL3	CUL3	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circCUL3 is up-regulated in gastric cancer tissues and cell lines and is associated with worse overall survival. It promotes GC cell proliferation and aerobic glycolysis (Warburg effect) by sponging miR-515-5p to increase STAT3, which then transcriptionally upregulates HK2; circCUL3 knockdown suppresses xenograft tumor growth."	0.8784
33230446	Molecular therapy. Nucleic acids	2020	circFN1 Mediates Sorafenib Resistance of Hepatocellular Carcinoma Cells by Sponging miR-1205 and Regulating E2F1 Expression.	hsa_circ_0058124	circFN1	hsa_circ_FN1	FN1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circFN1 (hsa_circ_0058124) is upregulated in HCC tissues and sorafenib-resistant HCC cells, and its high expression predicts poorer overall survival. Functionally, circFN1 promotes proliferation and sorafenib resistance while inhibiting sorafenib-induced apoptosis, at least partly by sponging miR-1205 to increase E2F1 expression."	0.8837
33230448	Molecular therapy. Nucleic acids	2020	"hsa_circ_0001955 Enhances In Vitro Proliferation, Migration, and Invasion of HCC Cells through miR-145-5p/NRAS Axis."	hsa_circ_0001955				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001955 is up-regulated in HCC tissues and cell lines and promotes HCC cell proliferation, migration, and invasion. Mechanistically, it acts in the cytoplasm as a sponge of miR-145-5p, thereby increasing NRAS expression via a ceRNA axis."	0.6777
33230453	Molecular therapy. Nucleic acids	2020	circNR3C1 Suppresses Bladder Cancer Progression through Acting as an Endogenous Blocker of BRD4/C-myc Complex.		circNR3C1 	hsa_circ_NR3C1	NR3C1	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"circNR3C1 (from NR3C1) is down-regulated in bladder cancer and suppresses tumor proliferation/tumorigenesis. It binds BRD4 in the nucleus, disrupts the BRD4_C-myc promoter complex, downregulates C-myc and downstream EZH2 transcription, thereby inhibiting BC progression."	0.7694
33230455	Molecular therapy. Nucleic acids	2020	circRNA CDR1as Promotes Pulmonary Artery Smooth Muscle Cell Calcification by Upregulating CAMK2D and CNN3 via Sponging miR-7-5p.	hsa_circ_0001946	CDR1as 	hsa_circ_CDR1	CDR1	pulmonary hypertension 	MONDO:0005149	pulmonary hypertension	up-regulated	RT-qPCR; ISH	"In hypoxia-induced pulmonary hypertension cellular context, CDR1as is up-regulated in HPASMCs and promotes osteogenic differentiation and calcification. Mechanistically, it sponges miR-7-5p to relieve repression of CAMK2D and CNN3, forming a CDR1as/miR-7-5p/CAMK2D-CNN3 ceRNA axis that drives mineralization."	0.657
33230464	Molecular therapy. Nucleic acids	2020	Exosome-Shuttled circSHOC2 from IPASs Regulates Neuronal Autophagy and Ameliorates Ischemic Brain Injury via the miR-7670-3p/SIRT1 Axis.	mmu_circ_0092670	circSHOC2 	mmu_circ_SHOC2	SHOC2	ischemic stroke 	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; Microarray	"In ischemic stroke models (OGD neurons and MCAO mice), astrocyte-derived exosomes enriched in circSHOC2 protect neurons. circSHOC2 predominantly localizes in the cytoplasm and acts as a sponge for miR-7670-3p to relieve repression of SIRT1, thereby modulating autophagy and reducing neuronal apoptosis."	0.7918
33230465	Molecular therapy. Nucleic acids	2020	Overexpression of circRNA circUCK2 Attenuates Cell Apoptosis in Cerebral Ischemia-Reperfusion Injury via miR-125b-5p/GDF11 Signaling.			mmu_circ_UCK2	UCK2	ischemia stroke 	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR	"circUCK2 is down-regulated in mouse cerebral ischemia-reperfusion injury (MCAO) and in OGD-treated HT-22 neurons. Restoring/overexpressing circUCK2 reduces neuronal apoptosis and improves neurological outcomes by sponging miR-125b-5p, increasing GDF11, and activating TGF-beta/Smad3 signaling."	0.6337
33230468	Molecular therapy. Nucleic acids	2020	circ_2858 Helps Blood-Brain Barrier Disruption by Increasing VEGFA via Sponging miR-93-5p during Escherichia coli Meningitis.		circ_2858	hsa_circ_SNX9	SNX9	Escherichia coli meningitis 	MONDO:0006753	Escherichia coli meningitis	up-regulated	RT-qPCR; RNA-seq	"circ_2858 is up-regulated in hBMECs upon meningitic E. coli infection and localizes mainly in the cytoplasm. It functions as a ceRNA that sponges miR-93-5p (miR-17 family), thereby increasing VEGFA expression and causing tight-junction protein disruption, which increases BBB permeability."	0.7519
33230478	Molecular therapy. Nucleic acids	2020	Circular RNA circRIMS1 Acts as a Sponge of miR-433-3p to Promote Bladder Cancer Progression by Regulating CCAR1 Expression.	hsa_circ_0132246	circRIMS1	hsa_circ_RIMS1	RIMS1	bladder cancer	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; RNA-seq	"circRIMS1 (hsa_circ_0132246), derived from RIMS1, is up-regulated in bladder cancer tissues and cell lines and is mainly localized in the cytoplasm. It promotes bladder cancer proliferation, migration, invasion, tumor growth and metastasis by sponging miR-433-3p to restore CCAR1 expression (circRIMS1/miR-433-3p/CCAR1 axis), with downstream association to EMT markers and Wnt/beta-catenin target genes (c-Myc, survivin)."	0.8343
33234130	Molecular cancer	2020	circPARD3 drives malignant progression and chemoresistance of laryngeal squamous cell carcinoma by inhibiting autophagy through the PRKCI-Akt-mTOR pathway.		circPARD3 	hsa_circ_PARD3	PARD3	laryngeal squamous cell carcinoma 	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circPARD3 is up-regulated in LSCC and mainly localizes in the cytoplasm. It promotes proliferation, migration/invasion and cisplatin chemoresistance by inhibiting autophagy via the miR-145-5p/PRKCI/Akt-mTOR axis, and high circPARD3 predicts poor survival."	0.8817
33234142	Journal of experimental & clinical cancer research : CR	2020	CircSOD2 induced epigenetic alteration drives hepatocellular carcinoma progression through activating JAK2/STAT3 signaling pathway.	hsa_circ_0004662	circSOD2	hsa_circ_SOD2	SOD2	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circSOD2 (hsa_circ_0004662) is upregulated in HCC tissues/cell lines and promotes proliferation, migration, cell-cycle progression, and xenograft tumor growth while inhibiting apoptosis. Mechanistically, EP300/WDR5 activate circSOD2 via H3K27ac/H3K4me3 at its promoter, and circSOD2 sponges miR-502-5p to increase DNMT3a, which methylates and suppresses SOCS3 to activate JAK2/STAT3, with STAT3 feeding back to upregulate circSOD2. High circSOD2 expression is associated with poor patient survival."	0.8496
33235500	Cancer management and research	2020	Circ_0062020 Knockdown Strengthens the Radiosensitivity of Prostate Cancer Cells.	hsa_circ_0062020	circ_0062020 			prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circ_0062020 is up-regulated in prostate cancer (especially radioresistant tumors) and reduces radiosensitivity. Mechanistically, it functions as a ceRNA by sponging miR-615-5p to upregulate TRIP13, thereby promoting proliferation/metastasis and inhibiting apoptosis under ionizing radiation, and it supports tumor growth in vivo."	0.6544
33236350	Journal of clinical laboratory analysis	2021	The microarray identification circular RNA hsa_circ_0105015 up-regulated involving inflammation pathway in essential hypertension.	hsa_circ_0105015				essential hypertension 	MONDO:0001134	essential hypertension	up-regulated	RT-qPCR; Microarray	"This study identifies hsa_circ_0105015 as up-regulated in essential hypertension and in TNF-alpha-induced endothelial inflammation. Bioinformatics prediction and expression correlation support an interaction with hsa-miR-637, suggesting hsa_circ_0105015 may contribute to inflammatory endothelial dysfunction and has potential diagnostic value."	0.5534
33237585	Journal of cellular and molecular medicine	2021	G protein-coupled oestrogen receptor promotes cell growth of non-small cell lung cancer cells via YAP1/QKI/circNOTCH1/m6A methylated NOTCH1 signalling.	hsa_circ_0089552	circNOTCH1	hsa_circ_NOTCH1	NOTCH1	non_small_cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"In NSCLC cells, circNOTCH1 is induced downstream of GPER via YAP1-TEAD_mediated transcriptional upregulation of the circRNA biogenesis factor QKI. circNOTCH1 promotes NSCLC cell growth and xenograft tumour growth by competing with NOTCH1 mRNA for METTL14 binding, thereby altering m6A-related regulation and increasing NOTCH1 mRNA stability and NOTCH1 protein expression."	0.6996
33238574	International journal of molecular sciences	2020	Identification of Two Novel Circular RNAs Deriving from BCL2L12 and Investigation of Their Potential Value as a Molecular Signature in Colorectal Cancer.		circ-BCL2L12-1	hsa_circ_BCL2L12	BCL2L12	colorectal cancer 	MONDO:0005575	colorectal cancer	unknown	RT-qPCR	"circ-BCL2L12-1 is a newly identified BCL2L12-derived circRNA in colorectal cancer. High circ-BCL2L12-1 levels are associated with shorter overall survival, and it is predicted to function through miRNA sponging (e.g., miR-1915-5p) and binding of splicing-related RBPs."	0.6548
33238574	International journal of molecular sciences	2020	Identification of Two Novel Circular RNAs Deriving from BCL2L12 and Investigation of Their Potential Value as a Molecular Signature in Colorectal Cancer.		circ-BCL2L12-2	hsa_circ_BCL2L12	BCL2L12	colorectal cancer 	MONDO:0005575	colorectal cancer	unknown	RT-qPCR	"circ-BCL2L12-2 is a newly identified BCL2L12-derived circRNA in colorectal cancer. Its expression is inversely associated with TNM stage, and it is predicted to interact with multiple miRNAs/RBPs and to contain an ORF (potential translation), though its prognostic value was not supported in this cohort."	0.5841
33239003	BMC pulmonary medicine	2020	"CircRNA0001859, a new diagnostic and prognostic biomarkers for COPD and AECOPD."		CircRNA0001859 			chronic obstructive pulmonary disease 	MONDO:0005002	chronic obstructive pulmonary disease	down-regulated	RT-qPCR; ISH; Microarray	circRNA0001859 is consistently down-regulated in COPD/AECOPD models and in patient serum. Its serum level correlates positively with lung function (FEV1%) and shows diagnostic potential for COPD and AECOPD based on ROC analysis.	0.6033
33239613	Cell death & disease	2020	CircCNTNAP3-TP53-positive feedback loop suppresses malignant progression of esophageal squamous cell carcinoma.	hsa_circ_0087104	cCNTNAP3 	hsa_circ_CNTNAP3	CNTNAP3	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	"cCNTNAP3 (hsa_circ_0087104), derived from CNTNAP3, is down-regulated in ESCC and suppresses malignant progression in p53 wild-type contexts. It sponges miR-513a-5p to increase TP53/p53 expression, while p53 promotes cCNTNAP3 biogenesis via RBM25, forming a positive feedback loop. Low cCNTNAP3 associates with advanced T stage and poorer overall survival in p53 wild-type ESCC."	0.8728
33239890	OncoTargets and therapy	2020	Hypoxic Tumor-Derived Exosomal Circ0048117 Facilitates M2 Macrophage Polarization Acting as miR-140 Sponge in Esophageal Squamous Cell Carcinoma.	hsa_circ_0048117		hsa_circ_ARID3A	ARID3A	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"In ESCC, hypoxia increases tumor-cell exosomal hsa-circ-0048117, which is transferred to macrophages and promotes M2 polarization. Mechanistically, hsa-circ-0048117 sponges miR-140 to relieve repression of TLR4, thereby enhancing M2 markers/cytokines and indirectly promoting ESCC cell migration and invasion."	0.8344
33239891	OncoTargets and therapy	2020	Circ_SATB2 Attenuates the Anti-Tumor Role of Celastrol in Non-Small-Cell Lung Carcinoma Through Targeting miR-33a-5p/E2F7 Axis.		circ_SATB2 	hsa_circ_SATB2	SATB2	non-small-cell lung carcinoma 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_SATB2 is up-regulated in NSCLC tissues and cell lines. It sponges miR-33a-5p to increase E2F7 expression, thereby promoting malignant phenotypes and weakening celastrol-induced anti-tumor effects, including in xenograft tumors."	0.7183
33239917	Cancer management and research	2020	Circ_0002232 Acts as a Potential Biomarker for AML and Reveals a Potential ceRNA Network of Circ_0002232/miR-92a-3p/PTEN.	hsa_circ_0002232	circ_0002232 	hsa_circ_PTEN	PTEN	acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	down-regulated	RT-qPCR	"circ_0002232 (a PTEN-derived circRNA) is down-regulated in AML bone marrow samples and shows diagnostic value for distinguishing AML patients from controls. The study proposes a potential ceRNA axis where circ_0002232 may sponge miR-92a-3p to influence PTEN expression, and circ_0002232 level is associated with overall survival in AML."	0.5121
33239918	Cancer management and research	2020	"Silencing circSLC19A1 Inhibits Prostate Cancer Cell Proliferation, Migration and Invasion Through Regulating miR-326/MAPK1 Axis."		CircSLC19A1	hsa_circ_SLC19A1	SLC19A1	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circSLC19A1 is up-regulated in prostate cancer tissues and cell lines and acts as an oncogenic circRNA. Its knockdown suppresses PCa cell proliferation/colony formation, migration and invasion by sponging miR-326 and thereby reducing MAPK1 expression (circSLC19A1/miR-326/MAPK1 ceRNA axis)."	0.7846
33240215	Frontiers in endocrinology	2020	Transcriptome Sequencing Analysis of Peripheral Blood of Type 2 Diabetes Mellitus Patients With Thirst and Fatigue.		novel_circ_0003372			type 2 diabetes mellitus	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RNA-seq	"novel_circ_0003372 was identified by RNA-seq as up-regulated in peripheral blood of D-T2DM patients versus healthy controls. The study constructed a circRNA_miRNA regulatory network and predicted that novel_circ_0003372 contains multiple miRNA binding sites, suggesting a potential miRNA-sponge role in D-T2DM."	0.1768
33240215	Frontiers in endocrinology	2020	Transcriptome Sequencing Analysis of Peripheral Blood of Type 2 Diabetes Mellitus Patients With Thirst and Fatigue.	hsa_circ_0057753				type 2 diabetes mellitus	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RNA-seq	"hsa_circ_0057753 was identified by RNA-seq as up-regulated in peripheral blood of D-T2DM patients compared with healthy controls, without further functional validation reported."	0.1155
33240215	Frontiers in endocrinology	2020	Transcriptome Sequencing Analysis of Peripheral Blood of Type 2 Diabetes Mellitus Patients With Thirst and Fatigue.	hsa_circ_0002590				type 2 diabetes mellitus	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RNA-seq	"hsa_circ_0002590 was up-regulated in peripheral blood from D-T2DM patients. Bioinformatics/network analysis suggested it is associated with MiR-149-5p and may act as a competing endogenous RNA to inhibit MiR-149-5p function, potentially affecting insulin secretion-related regulation."	0.1768
33240215	Frontiers in endocrinology	2020	Transcriptome Sequencing Analysis of Peripheral Blood of Type 2 Diabetes Mellitus Patients With Thirst and Fatigue.	hsa_circ_0003940				type 2 diabetes mellitus	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RNA-seq	"hsa_circ_0003940 was up-regulated in peripheral blood of D-T2DM patients and included in the circRNA_miRNA network with many predicted miRNA binding sites, suggesting a potential miRNA-sponge role in D-T2DM."	0.1768
33240215	Frontiers in endocrinology	2020	Transcriptome Sequencing Analysis of Peripheral Blood of Type 2 Diabetes Mellitus Patients With Thirst and Fatigue.	hsa_circ_0004086				type 2 diabetes mellitus	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RNA-seq	"hsa_circ_0004086 was up-regulated in peripheral blood of D-T2DM patients and included in the predicted circRNA_miRNA network with many miRNA binding sites, suggesting a potential miRNA-sponge role."	0.1768
33240215	Frontiers in endocrinology	2020	Transcriptome Sequencing Analysis of Peripheral Blood of Type 2 Diabetes Mellitus Patients With Thirst and Fatigue.	hsa_circ_0007643				type 2 diabetes mellitus	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RNA-seq	"hsa_circ_0007643 was identified by RNA-seq as down-regulated in peripheral blood of D-T2DM patients compared with healthy controls, without further functional validation reported."	0.1155
33240215	Frontiers in endocrinology	2020	Transcriptome Sequencing Analysis of Peripheral Blood of Type 2 Diabetes Mellitus Patients With Thirst and Fatigue.	hsa_circ_0002909				type 2 diabetes mellitus	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RNA-seq	"hsa_circ_0002909 was identified by RNA-seq as down-regulated in peripheral blood of D-T2DM patients compared with healthy controls, without further functional validation reported."	0.1155
33240215	Frontiers in endocrinology	2020	Transcriptome Sequencing Analysis of Peripheral Blood of Type 2 Diabetes Mellitus Patients With Thirst and Fatigue.	hsa_circ_0036353				type 2 diabetes mellitus	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RNA-seq	"hsa_circ_0036353 was down-regulated in peripheral blood of D-T2DM patients and included in the predicted circRNA_miRNA network with multiple miRNA binding sites, suggesting a potential miRNA-sponge role, though specific miRNAs were not listed for this circRNA."	0.1768
33240215	Frontiers in endocrinology	2020	Transcriptome Sequencing Analysis of Peripheral Blood of Type 2 Diabetes Mellitus Patients With Thirst and Fatigue.		novel_circ_0011589			type 2 diabetes mellitus	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RNA-seq	"novel_circ_0011589 was identified by RNA-seq as down-regulated in peripheral blood of D-T2DM patients compared with healthy controls, without additional mechanistic analysis reported for this circRNA."	0.1155
33240215	Frontiers in endocrinology	2020	Transcriptome Sequencing Analysis of Peripheral Blood of Type 2 Diabetes Mellitus Patients With Thirst and Fatigue.	hsa_circ_0028247				type 2 diabetes mellitus	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RNA-seq	"hsa_circ_0028247 was identified by RNA-seq as down-regulated in peripheral blood of D-T2DM patients compared with healthy controls, without additional mechanistic analysis reported for this circRNA."	0.1155
33240215	Frontiers in endocrinology	2020	Transcriptome Sequencing Analysis of Peripheral Blood of Type 2 Diabetes Mellitus Patients With Thirst and Fatigue.		novel_circ_0003446			type 2 diabetes mellitus	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RNA-seq	"novel_circ_0003446 was identified by RNA-seq as down-regulated in peripheral blood of D-T2DM patients compared with healthy controls, without additional mechanistic analysis reported for this circRNA."	0.1155
33240215	Frontiers in endocrinology	2020	Transcriptome Sequencing Analysis of Peripheral Blood of Type 2 Diabetes Mellitus Patients With Thirst and Fatigue.		novel_circ_0016196			type 2 diabetes mellitus	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RNA-seq	"novel_circ_0016196 was down-regulated in peripheral blood of D-T2DM patients. Network analysis indicated it is associated with MiR-877-3p, and the authors suggest that reduced circRNA levels could increase MiR-877-3p activity and potentially contribute to mitochondrial apoptosis-related mechanisms in D-T2DM."	0.1768
33240215	Frontiers in endocrinology	2020	Transcriptome Sequencing Analysis of Peripheral Blood of Type 2 Diabetes Mellitus Patients With Thirst and Fatigue.	hsa_circ_0036348				type 2 diabetes mellitus	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RNA-seq	"hsa_circ_0036348 was identified by RNA-seq as down-regulated in peripheral blood of D-T2DM patients compared with healthy controls, without additional mechanistic analysis reported for this circRNA."	0.1155
33240215	Frontiers in endocrinology	2020	Transcriptome Sequencing Analysis of Peripheral Blood of Type 2 Diabetes Mellitus Patients With Thirst and Fatigue.		novel_circ_0016198			type 2 diabetes mellitus	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RNA-seq	"novel_circ_0016198 was down-regulated in peripheral blood of D-T2DM patients. Network analysis linked it to MiR-877-3p, and the authors propose that reduced levels of these circRNAs could enhance MiR-877-3p function and potentially influence mitochondrial apoptosis-related processes in D-T2DM."	0.1768
33240215	Frontiers in endocrinology	2020	Transcriptome Sequencing Analysis of Peripheral Blood of Type 2 Diabetes Mellitus Patients With Thirst and Fatigue.		novel_circ_0036259			type 2 diabetes mellitus	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RNA-seq	"novel_circ_0036259 was identified by RNA-seq as down-regulated in peripheral blood of D-T2DM patients compared with healthy controls, without additional mechanistic analysis reported for this circRNA."	0.1155
33240996	Annals of translational medicine	2020	Interference of circRNA HIPK3 alleviates cardiac dysfunction in lipopolysaccharide-induced mice models and apoptosis in H9C2 cardiomyocytes.		circHIPK3 	rno_circ_HIPK3	HIPK3	LPS-induced myocarditis 	MONDO:0004496	myocarditis	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in LPS-induced myocarditis models (mouse myocardium and H9C2 cells). circHIPK3 knockdown improves cardiac function and reduces myocardial injury by inhibiting cardiomyocyte apoptosis, oxidative stress, and inflammation, while partially restoring cell proliferation."	0.5445
33244865	Molecular oncology	2021	"Circ_0008039 supports breast cancer cell proliferation, migration, invasion, and glycolysis by regulating the miR-140-3p/SKA2 axis."	hsa_circ_0008039	Circ_0008039	hsa_circ_PRKAR1B	PRKAR1B	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0008039 is up-regulated in breast cancer (TNBC) tissues and cells and correlates with advanced stage and lymph node metastasis. Functionally, circ_0008039 promotes proliferation, migration/invasion, and glycolysis. Mechanistically, it acts as a ceRNA by sponging miR-140-3p to increase SKA2 expression, thereby supporting tumor growth in xenografts."	0.7795
33245100	Bioscience reports	2020	Regulation of circGOLPH3 and its binding protein CBX7 on the proliferation and apoptosis of prostate cancer cells.	hsa_circ_0072068	circGOLPH3	hsa_circ_GOLPH3	GOLPH3	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"In prostate cancer PC-3 cells, circGOLPH3 is upregulated and promotes proliferation/viability while inhibiting apoptosis. Mechanistically, circGOLPH3 directly binds CBX7, and CBX7 overexpression phenocopies circGOLPH3¡¯s pro-proliferative and anti-apoptotic effects."	0.6738
33247464	"Brain pathology (Zurich, Switzerland)"	2021	Distinct circular RNA expression profiles in pediatric ependymomas.		circSMARCA5	hsa_circ_SMARCA5	SMARCA5	pediatric ependymomas 	MONDO:0003478	childhood ependymoma	down-regulated	RNA-seq	"circSMARCA5 is significantly down-regulated in pediatric ependymoma tissue versus controls based on RNA-seq profiling, highlighting it as a potentially disease-associated circRNA (functional mechanism not tested in this study)."	0.1768
33247464	"Brain pathology (Zurich, Switzerland)"	2021	Distinct circular RNA expression profiles in pediatric ependymomas.		circ_FBXW7 	hsa_circ_FBXW7	FBXW7	pediatric ependymomas 	MONDO:0003478	childhood ependymoma	down-regulated	RNA-seq	circ-FBXW7 is significantly down-regulated in pediatric ependymomas compared with control brain tissue in the RNA-seq profiling; no functional mechanism was experimentally investigated for this circRNA in this study.	0.1768
33247464	"Brain pathology (Zurich, Switzerland)"	2021	Distinct circular RNA expression profiles in pediatric ependymomas.		circRMST	hsa_circ_RMST	RMST	pediatric ependymomas 	MONDO:0003478	childhood ependymoma	up-regulated	RNA-seq	circRMST is up-regulated in pediatric ependymomas versus control brain tissue and appears relatively specific to ependymoma compared with other pediatric brain tumor entities in the NanoString panel; functional mechanisms were not experimentally tested.	0.348
33247464	"Brain pathology (Zurich, Switzerland)"	2021	Distinct circular RNA expression profiles in pediatric ependymomas.		circLRBA	hsa_circ_LRBA	LRBA	pediatric ependymomas 	MONDO:0003478	childhood ependymoma	up-regulated	Others	circLRBA (LRBA-derived circRNA) is reported as specifically up-regulated in pediatric ependymomas versus controls in the NanoString validation cohort; no molecular mechanism was tested.	0.2629
33247464	"Brain pathology (Zurich, Switzerland)"	2021	Distinct circular RNA expression profiles in pediatric ependymomas.		circWDR78	hsa_circ_WDR78	WDR78	pediatric ependymomas 	MONDO:0003478	childhood ependymoma	up-regulated	Others	circWDR78 (WDR78-derived circRNA) is reported as strongly and specifically up-regulated in pediatric ependymomas versus controls in the NanoString-based analysis; functional mechanism was not investigated.	0.2629
33247464	"Brain pathology (Zurich, Switzerland)"	2021	Distinct circular RNA expression profiles in pediatric ependymomas.		circDRC1	hsa_circ_DRC1	DRC1	pediatric ependymomas 	MONDO:0003478	childhood ependymoma	up-regulated	Others	circDRC1 (DRC1-derived circRNA) is reported as specifically up-regulated in pediatric ependymomas versus controls in the NanoString cohort; mechanism/function was not tested.	0.2629
33247464	"Brain pathology (Zurich, Switzerland)"	2021	Distinct circular RNA expression profiles in pediatric ependymomas.		circBBS9	hsa_circ_BBS9	BBS9	pediatric ependymomas 	MONDO:0003478	childhood ependymoma	up-regulated	Others	circBBS9 (BBS9-derived circRNA) is reported as specifically up-regulated in pediatric ependymomas versus controls in the NanoString cohort; no mechanism was tested.	0.2629
33255923	Biomedicines	2020	Whole-Transcriptome Analysis in Peripheral Blood Mononuclear Cells from Patients with Lipid-Specific Oligoclonal IgM Band Characterization Reveals Two Circular RNAs and Two Linear RNAs as Biomarkers of Highly Active Disease.	hsa_circ_0000478	Circ_0000478	hsa_circ_VWA8	VWA8	multiple sclerosis 	MONDO:0005301	multiple sclerosis	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000478 (Circ_0000478/circ_0000478), derived from host gene VWA8, is downregulated in PBMCs of MS patients with positive LS-OCMBs and was validated by RT-qPCR after RNA-seq discovery. It was evaluated as a minimally invasive blood biomarker to discriminate LS-OCMB+ vs LS-OCMB_ patients (ROC AUC ~66% alone; improved in combinations)."	0.6841
33255923	Biomedicines	2020	Whole-Transcriptome Analysis in Peripheral Blood Mononuclear Cells from Patients with Lipid-Specific Oligoclonal IgM Band Characterization Reveals Two Circular RNAs and Two Linear RNAs as Biomarkers of Highly Active Disease.	hsa_circ_0116639	circ_0116639	hsa_circ_EP300	EP300	multiple sclerosis 	MONDO:0005301	multiple sclerosis	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0116639 (circ_0116639), overlapping the EP300 gene, is downregulated in PBMCs of MS patients with positive LS-OCMBs and was validated by RT-qPCR after RNA-seq discovery. It was assessed as a minimally invasive blood biomarker for highly active/aggressive MS, showing moderate discrimination performance (ROC AUC ~66% alone; improved in combinations)."	0.6841
33256799	Journal of experimental & clinical cancer research : CR	2020	Tumor promoting effects of circRNA_001287 on renal cell carcinoma through miR-144-targeted CEP55.	hsa_circ_0000990	circ_001287 			renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR; Microarray	"circ_001287 is up-regulated in RCC tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion) and xenograft tumor growth while inhibiting apoptosis. Mechanistically, circ_001287 binds miR-144 (cytoplasmic co-localization) to relieve repression of the miR-144 target CEP55, forming a circ_001287/miR-144/CEP55 ceRNA axis."	0.7633
33257506	Molecular and cellular biology	2021	Circular RNA 100146 Promotes Colorectal Cancer Progression by the MicroRNA 149/HMGA2 Axis.	hsa_circ_0011385	circRNA 100146	hsa_circ_EIF3I	EIF3I	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circRNA 100146 (hsa_circ_0011385, from EIF3I) is upregulated in colorectal cancer tissues and cell lines. It promotes CRC proliferation, migration/invasion and tumor growth/metastasis and inhibits apoptosis by sponging miR-149 to upregulate HMGA2 (circRNA 100146/miR-149/HMGA2 axis)."	0.8275
33262782	Frontiers in genetics	2020	"CircRNA_100876 Is Upregulated in Gastric Cancer (GC) and Promotes the GC Cells' Growth, Migration and Invasion via miR-665/YAP1 Signaling."		CircRNA_100876 			gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circRNA_100876 is up-regulated in gastric cancer tissues/cells and its high expression is associated with worse patient survival. Functionally, circRNA_100876 promotes GC cell proliferation, migration, invasion and EMT while inhibiting apoptosis, mainly by sponging miR-665 to relieve repression of YAP1."	0.7126
33262952	Frontiers in oncology	2020	"Circular RNA circGSK3B Promotes Cell Proliferation, Migration, and Invasion by Sponging miR-1265 and Regulating CAB39 Expression in Hepatocellular Carcinoma."	hsa_circ_0003763	circGSK3B	hsa_circ_GSK3B	GSK3B	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circGSK3B (hsa_circ_0003763), derived from GSK3B, is up-regulated in HCC tissues and cell lines and promotes proliferation, migration, invasion and in vivo tumor growth/metastasis. Mechanistically, it sponges miR-1265 to upregulate CAB39 and activate downstream ERK/EMT, and it also enhances glutamine metabolism by increasing GLS expression; QKI promotes its biogenesis."	0.8546
33264494	Journal of cellular and molecular medicine	2021	Circular RNA hsa_circ_0000658 inhibits osteosarcoma cell proliferation and migration via the miR-1227/IRF2 axis.	hsa_circ_0000658	circ-0000658 			Osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0000658 is down-regulated in osteosarcoma tissues/cell lines and acts as a tumor suppressor. It sponges miR-1227 to increase IRF2, thereby inhibiting proliferation/invasion, promoting apoptosis, and suppressing tumour growth and lung metastasis; higher circ-0000658 associates with better overall survival."	0.8428
33268793	Cell death & disease	2020	"A novel circular RNA, circXPO1, promotes lung adenocarcinoma progression by interacting with IGF2BP1."	hsa_circ_0001016	circXPO1	hsa_circ_XPO1	XPO1	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circXPO1 (hsa_circ_0001016), derived from XPO1 exon 3-4, is upregulated in LUAD and correlates with worse overall survival. It predominantly localizes in the cytoplasm, binds the RBP IGF2BP1, enhances CTNNB1 mRNA stability and CTNNB1 protein expression, thereby promoting LUAD cell proliferation and migration/invasion and tumor growth; circXPO1 knockdown suppresses growth in xenograft and PDX models."	0.8783
33276753	BMC cancer	2020	A novel circular RNA hsa_circRNA_103809/miR-377-3p/GOT1 pathway regulates cisplatin-resistance in non-small cell lung cancer (NSCLC).		hsa_circRNA_103809			non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circRNA_103809 is up-regulated in cisplatin-resistant NSCLC cells and promotes cisplatin resistance. It functions as a ceRNA by sponging miR-377-3p to increase GOT1, thereby maintaining proliferation/viability and suppressing apoptosis under cisplatin; silencing it sensitizes resistant cells and inhibits xenograft growth with cisplatin."	0.7581
33281969	Oncology letters	2021	Circular RNA hsa_circ_0005114-miR-142-3p/miR-590-5p-adenomatous polyposis coli protein axis as a potential target for treatment of glioma.	hsa_circ_0005114		hsa_circ_RIMS2	RIMS2	glioma 	MONDO:0021042	glioma	down-regulated	RNA-seq	"This study (bioinformatics) identified hsa_circ_0005114 as a downregulated circRNA in glioma and predicted it interacts with hsa-miR-142-3p and hsa-miR-590-5p in a ceRNA axis targeting APC. Functional enrichment suggested a link to insulin secretion, while the axis connects to APC/Wnt signaling in glioma."	0.5135
33290265	Aging	2020	Hsa_circ_0079480 promotes tumor progression in acute myeloid leukemia via miR-654-3p/HDGF axis.	hsa_circ_0079480		hsa_circ_ISPD	ISPD	acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"hsa_circ_0079480 is up-regulated in AML bone marrow and mainly localized in the cytoplasm. It promotes AML cell proliferation and suppresses apoptosis by acting as a ceRNA that sponges miR-654-3p, thereby relieving inhibition of HDGF; rescue experiments support the hsa_circ_0079480/miR-654-3p/HDGF axis as the mechanism."	0.8267
33292166	Cellular & molecular biology letters	2020	hsa_circ_0006916 promotes hepatocellular carcinoma progression by activating the miR-337-3p/STAT3 axis.	hsa_circ_0006916	circ_0006916			hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"hsa_circ_0006916 is up-regulated in hepatocellular carcinoma tissues and cell lines and promotes proliferation and invasion. Mechanistically, it localizes to the cytoplasm and functions as a miR-337-3p sponge to increase STAT3 expression, forming a hsa_circ_0006916/miR-337-3p/STAT3 axis linked to aggressive clinical features."	0.7477
33292234	Cancer cell international	2020	Circ0120816 acts as an oncogene of esophageal squamous cell carcinoma by inhibiting miR-1305 and releasing TXNRD1.	hsa_circ_0120816 	circ0120816 			esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circ0120816 is up-regulated in ESCC and functions as an oncogenic circRNA. It mainly localizes to the cytoplasm and promotes ESCC cell viability/proliferation/adhesion while inhibiting apoptosis by sponging miR-1305 to derepress TXNRD1, and its silencing suppresses xenograft tumor growth and lung metastasis."	0.8399
33292236	Cancer cell international	2020	Exosome-transferred hsa_circ_0014235 promotes DDP chemoresistance and deteriorates the development of non-small cell lung cancer by mediating the miR-520a-5p/CDK4 pathway.	hsa_circ_0014235		hsa_circ_S100A2	S100A2	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0014235 is up-regulated in NSCLC tumor tissues, NSCLC cells, and NSCLC patient serum-derived exosomes. It promotes cisplatin (DDP) chemoresistance and malignant phenotypes (proliferation, migration/invasion, cell-cycle progression) while inhibiting apoptosis, partly through an exosome-associated ceRNA axis hsa_circ_0014235/miR-520a-5p/CDK4."	0.6833
33292243	Cancer cell international	2020	"CircSMYD4 regulates proliferation, migration and apoptosis of hepatocellular carcinoma cells by sponging miR-584-5p."	hsa_circ_0004018	circSMYD4	hsa_circ_SMYD4	SMYD4	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"circSMYD4 (hsa_circ_0004018), derived from SMYD4, is down-regulated in HCC tissues/cells and predominantly localized in the cytoplasm. Functionally, circSMYD4 acts as a tumor suppressor by inhibiting proliferation, migration/invasion and EMT while promoting apoptosis and reducing xenograft tumor growth. Mechanistically, it sponges miR-584-5p, and miR-584-5p overexpression partially rescues circSMYD4-mediated effects."	0.8596
33292255	Cancer cell international	2020	Circ_0015756 promotes the progression of ovarian cancer by regulating miR-942-5p/CUL4B pathway.	hsa_circ_0015756	circ_0015756	hsa_circ_CFH	CFH	ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circ_0015756 is up-regulated in ovarian cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes OC cell proliferation, migration and invasion and inhibits apoptosis by sponging miR-942-5p to increase CUL4B expression, and its knockdown suppresses tumor growth in a xenograft model."	0.7294
33292256	Cancer cell international	2020	Hsa_circ_0004831 serves as a blood-based prognostic biomarker for colorectal cancer and its potentially circRNA-miRNA-mRNA regulatory network construction.	hsa_circ_0004831		hsa_circ_RSF1	RSF1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0004831 is up-regulated in CRC serum/blood extracellular vesicles and its high expression is associated with poorer overall survival, suggesting it as a blood-based prognostic biomarker. The study proposes a ceRNA network in which hsa_circ_0004831 may regulate hsa-miR-4326 and downstream mRNAs, with co-expressed genes enriched in EMT, WNT and p53-related pathways."	0.5534
33293827	OncoTargets and therapy	2020	Identification of a Functional ceRNA Network to Explore Potential Biomarkers for Hepatocellular Carcinoma.	hsa_circ_0130911	circ_0130911	hsa_circ_UTRN	UTRN	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ_0130911 (hsa_circ_0130911), derived from UTRN, is up-regulated in HCC tissues and higher in early recurring HCC. It is associated with poor prognosis and may function as a ceRNA by sponging multiple miRNAs to regulate cell cycle-related hub genes within a predicted circRNA_miRNA_mRNA network."	0.6201
33293831	OncoTargets and therapy	2020	TRPS1 and YAP1 Regulate Cell Proliferation and Drug Resistance of Osteosarcoma via Competitively Binding to the Target of circTADA2A - miR-129-5p.		circTADA2A 	hsa_circ_TADA2A	TADA2A	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circTADA2A is up-regulated in osteosarcoma cell lines and promotes proliferation and cisplatin (DDP) resistance. Mechanistically, it sponges miR-129-5p to increase TRPS1 and YAP1 expression and modulate YAP1 phosphorylation, and its knockdown suppresses xenograft tumor growth and improves DDP sensitivity."	0.6216
33294447	BioMed research international	2020	Transcriptomic Analysis of circRNAs in the Peripheral Blood of Nonarteritic Anterior Ischemic Optic Neuropathy.	hsa_circ_0005583		hsa_circ_ATM	ATM	nonarteritic anterior ischemic optic neuropathy 	MONDO:0000499	non-arteritic anterior ischemic optic neuropathy	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005583 (ATM-derived) is significantly down-regulated in peripheral blood of NAION patients and is proposed to relate to neurodegeneration/oxidative-stress-associated processes. The study predicts it may act via RBP eFI4A3 and involvement in nonsense-mediated mRNA decay, suggesting biomarker potential."	0.4032
33294447	BioMed research international	2020	Transcriptomic Analysis of circRNAs in the Peripheral Blood of Nonarteritic Anterior Ischemic Optic Neuropathy.	hsa_circ_0003922		hsa_circ_SP100	SP100	nonarteritic anterior ischemic optic neuropathy 	MONDO:0000499	non-arteritic anterior ischemic optic neuropathy	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0003922 (SP100-derived) is significantly down-regulated in NAION peripheral blood and was validated by RT-qPCR consistent with sequencing. It is bioinformatically predicted to share the RBP eFI4A3 with other key down-regulated circRNAs, suggesting possible involvement in RNA-processing pathways and biomarker potential."	0.4032
33294447	BioMed research international	2020	Transcriptomic Analysis of circRNAs in the Peripheral Blood of Nonarteritic Anterior Ischemic Optic Neuropathy.	hsa_circ_0002021		hsa_circ_FRYL	FRYL	nonarteritic anterior ischemic optic neuropathy 	MONDO:0000499	non-arteritic anterior ischemic optic neuropathy	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0002021 (FRYL-derived) is significantly down-regulated in NAION peripheral blood and was validated by RT-qPCR consistent with sequencing. It is predicted to interact with the RBP eFI4A3, suggesting a possible connection to RNA surveillance/processing such as nonsense-mediated mRNA decay."	0.4032
33294447	BioMed research international	2020	Transcriptomic Analysis of circRNAs in the Peripheral Blood of Nonarteritic Anterior Ischemic Optic Neuropathy.	hsa_circ_0000462		hsa_circ_SLC15A4	SLC15A4	nonarteritic anterior ischemic optic neuropathy 	MONDO:0000499	non-arteritic anterior ischemic optic neuropathy	down-regulated	RNA-seq	"hsa_circ_0000462 (SLC15A4-derived) was identified among the key NAION-associated circRNAs, but its qRT-PCR validation was opposite to sequencing, lowering evidence strength. It is predicted to share the RBP eFI4A3 with other dysregulated circRNAs, suggesting potential involvement in RNA-processing pathways."	0.4032
33298061	Cancer cell international	2020	"Circular RNA circPLK1 promotes breast cancer cell proliferation, migration and invasion by regulating miR-4500/IGF1 axis."	hsa_circ_0038632	circPLK1 	hsa_circ_PLK1	PLK1	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circPLK1 is up-regulated in breast cancer tissues and cells and functions as an oncogenic circRNA. It promotes proliferation, cell-cycle progression, migration and invasion, at least partly by sponging miR-4500 to increase IGF1 expression, and its knockdown suppresses xenograft tumor growth."	0.7591
33298118	Journal of orthopaedic surgery and research	2020	Plasma and local expressions of CircRNA CDR1as are linked with disease severity in patients with non-traumatic osteonecrosis of femoral head.		CircRNA CDR1as 	hsa_circ_CDR1AS	CDR1AS	non-traumatic osteonecrosis of femoral head 	MONDO:0005380	osteonecrosis	up-regulated	RT-qPCR	"CircCDR1as is up-regulated in plasma of non-traumatic ONFH patients and in local necrotic femoral-head tissue versus adjacent non-necrotic tissue. Higher plasma/local levels correlate with worse radiographic stage (ARCO) and worse symptoms (higher VAS, lower HHS), and plasma CircCDR1as shows potential as a biomarker for radiographic progression."	0.4187
33298186	Stem cell research & therapy	2020	circAKT3 positively regulates osteogenic differentiation of human dental pulp stromal cells via miR-206/CX43 axis.		circAKT3	hsa_circ_AKT3	AKT3	osteogenic differentiation 	MONDO:0005381	bone disorder	up-regulated	RT-qPCR; RNA-seq	"circAKT3 is up-regulated during osteogenic differentiation of hDPSCs and promotes osteogenesis/mineralization. Mechanistically, it directly sponges miR-206, thereby relieving miR-206-mediated repression of CX43."	0.7369
33304235	Frontiers in neuroscience	2020	Prenatal Alcohol Exposure Results in Sex-Specific Alterations in Circular RNA Expression in the Developing Mouse Brain.		circSatb2	mmu_circ_Satb2	Satb2	fetal alcohol spectrum disorders 	MONDO:0000408	fetal alcohol spectrum disorder	up-regulated	RT-qPCR; Microarray	"In the E18 mouse brain, prenatal alcohol exposure increases circSatb2 in males but not females. circSatb2 levels inversely correlate with neuronal marker mRNAs and show negative association with Bdnf, suggesting a potential link to sex-specific neurodevelopmental regulation in the PAE/FASD model."	0.5618
33304235	Frontiers in neuroscience	2020	Prenatal Alcohol Exposure Results in Sex-Specific Alterations in Circular RNA Expression in the Developing Mouse Brain.		circPtchd2 	mmu_circ_Ptchd2	Ptchd2	fetal alcohol spectrum disorders 	MONDO:0000408	fetal alcohol spectrum disorder	dysregulated	RT-qPCR; Microarray	"circPtchd2 displays sex-dimorphic expression in control E18 mouse brain (female > male), and this dimorphism is abolished by prenatal alcohol exposure. The study suggests (without direct mechanistic proof) that its synthesis could be influenced by thyroid hormone signaling and reports correlations with neuronal/glial marker expression."	0.5618
33308021	Technology in cancer research & treatment	2020	The Analysis of Differentially Expressed circRNAs Under the Antiproliferative Effect From 5-Fluorouracil on Osteosarcoma Cells.	hsa_circ_0001013		hsa_circ_KIAA1841	KIAA1841	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0001013 is up-regulated in MG63 osteosarcoma cells after 5-FU treatment and is included in predicted circRNA_miRNA_mRNA networks related to proliferation/apoptosis. It was predicted to target hsa-let-7 g and may be involved in regulation of HOXB1 and NF-kappaB signaling during 5-FU response.	0.5608
33308021	Technology in cancer research & treatment	2020	The Analysis of Differentially Expressed circRNAs Under the Antiproliferative Effect From 5-Fluorouracil on Osteosarcoma Cells.	hsa_circ_0034616		hsa_circ_RAD51	RAD51	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0034616 is up-regulated in 5-FU-treated MG63 osteosarcoma cells and was included in predicted circRNA_miRNA_mRNA networks related to proliferation/apoptosis. It was predicted to target miR-18a-5p, suggesting a ceRNA-like role during 5-FU response."	0.4761
33308021	Technology in cancer research & treatment	2020	The Analysis of Differentially Expressed circRNAs Under the Antiproliferative Effect From 5-Fluorouracil on Osteosarcoma Cells.		hsa_circ_00116639	hsa_circ_EP300	EP300	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_00116639 (EP300-derived) is up-regulated in 5-FU-treated MG63 osteosarcoma cells and is part of predicted circRNA_miRNA_mRNA regulatory networks linked to proliferation/apoptosis.	0.4761
33308021	Technology in cancer research & treatment	2020	The Analysis of Differentially Expressed circRNAs Under the Antiproliferative Effect From 5-Fluorouracil on Osteosarcoma Cells.			hsa_circ_FAM172A	FAM172A	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_FAM172A is up-regulated in 5-FU-treated MG63 osteosarcoma cells and is included in predicted circRNA_miRNA_mRNA networks associated with proliferation and apoptosis.	0.4761
33308021	Technology in cancer research & treatment	2020	The Analysis of Differentially Expressed circRNAs Under the Antiproliferative Effect From 5-Fluorouracil on Osteosarcoma Cells.	hsa_circ_0005694		hsa_circ_AHRR	AHRR	osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005694 is down-regulated in MG63 osteosarcoma cells after 5-FU treatment and was analyzed within predicted circRNA_miRNA_mRNA networks linked to proliferation and apoptosis. It was predicted to bind miR-150-5p, and downstream mRNA/protein changes were examined by qPCR/WB in the study¡¯s network validation."	0.5608
33308021	Technology in cancer research & treatment	2020	The Analysis of Differentially Expressed circRNAs Under the Antiproliferative Effect From 5-Fluorouracil on Osteosarcoma Cells.	hsa_circ_0007386		hsa_circ_CRIM1	CRIM1	osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0007386 is down-regulated in 5-FU-treated MG63 osteosarcoma cells and is part of predicted circRNA_miRNA_mRNA networks associated with proliferation and apoptosis.	0.4761
33308021	Technology in cancer research & treatment	2020	The Analysis of Differentially Expressed circRNAs Under the Antiproliferative Effect From 5-Fluorouracil on Osteosarcoma Cells.	hsa_circ_0008362		hsa_circ_FBXW4	FBXW4	osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0008362 is down-regulated in 5-FU-treated MG63 osteosarcoma cells and was included in predicted circRNA_miRNA_mRNA networks related to proliferation/apoptosis. It was predicted to target miR-18a-5p, suggesting coordinated regulation with other circRNAs during 5-FU response."	0.4761
33308021	Technology in cancer research & treatment	2020	The Analysis of Differentially Expressed circRNAs Under the Antiproliferative Effect From 5-Fluorouracil on Osteosarcoma Cells.	hsa_circ_0073817		hsa_circ_ADAMTS19	ADAMTS19	osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0073817 is down-regulated in 5-FU-treated MG63 osteosarcoma cells and is included in predicted proliferation/apoptosis-related circRNA_miRNA_mRNA networks. It was one of three circRNAs selected for downstream mRNA validation by qPCR and western blot in support of the network relationships.	0.5608
33308253	Journal of translational medicine	2020	Circular RNA expression profiles and features in NAFLD mice: a study using RNA-seq data.		circRNA_0010514 			Nonalcoholic fatty liver disease 	MONDO:0013209	metabolic dysfunction-associated steatotic liver disease	up-regulated	RT-qPCR; RNA-seq	"In HFD-induced NAFLD mouse liver tissues, circRNA_0010514 was identified by circRNA-seq as differentially expressed and its up-regulation was confirmed by RT-qPCR with consistency to sequencing results."	0.6903
33308253	Journal of translational medicine	2020	Circular RNA expression profiles and features in NAFLD mice: a study using RNA-seq data.		chr4_46734057_46749582			Nonalcoholic fatty liver disease 	MONDO:0013209	metabolic dysfunction-associated steatotic liver disease	up-regulated	RT-qPCR; RNA-seq	"In HFD-induced NAFLD mouse liver tissues, chr4_46734057_46749582 was identified as up-regulated by circRNA-seq and this up-regulation was confirmed by RT-qPCR, consistent with sequencing."	0.6903
33308253	Journal of translational medicine	2020	Circular RNA expression profiles and features in NAFLD mice: a study using RNA-seq data.	mmu_circ_0015959				Nonalcoholic fatty liver disease 	MONDO:0013209	metabolic dysfunction-associated steatotic liver disease	unknown	RT-qPCR; RNA-seq	"mmu_circ_0015959 was among the randomly selected dysregulated circRNAs and showed statistically significant differential expression by RT-qPCR in NAFLD mouse liver, but the direction (up or down) was not explicitly stated in the text provided."	0.4276
33308253	Journal of translational medicine	2020	Circular RNA expression profiles and features in NAFLD mice: a study using RNA-seq data.		chr7_82671604_82674582			Nonalcoholic fatty liver disease 	MONDO:0013209	metabolic dysfunction-associated steatotic liver disease	unknown	RT-qPCR; RNA-seq	"chr7_82671604_82674582 showed statistically significant differential expression by RT-qPCR in NAFLD mouse liver among the randomly selected dysregulated circRNAs, but the text provided does not specify whether it is up- or down-regulated."	0.4276
33308276	Diagnostic pathology	2020	Circ_0003998 enhances doxorubicin resistance in hepatocellular carcinoma by regulating miR-218-5p/EIF5A2 pathway.	hsa_circ_0003998	circ_0003998			hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0003998 is up-regulated in HCC, particularly in DOX-resistant tissues/cells, and promotes DOX resistance along with migration, invasion and EMT. Mechanistically, it acts as a ceRNA that sponges miR-218-5p to increase EIF5A2 expression, and its knockdown sensitizes HCC cells to DOX in vitro and in xenograft models."	0.7177
33308284	Journal of experimental & clinical cancer research : CR	2020	Circular RNA hsa_circ_0001829 promotes gastric cancer progression through miR-155-5p/SMAD2 axis.	hsa_circ_0001829		hsa_circ_SLC45A4	SLC45A4	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"hsa_circ_0001829 is up-regulated in gastric cancer tissues and cell lines and promotes proliferation, migration, invasion, cell-cycle progression, and tumor growth/metastasis. Mechanistically, it mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-155-5p to upregulate SMAD2, thereby driving GC progression."	0.8595
33308298	Journal of experimental & clinical cancer research : CR	2020	CircCDKN2B-AS1 interacts with IMP3 to stabilize hexokinase 2 mRNA and facilitate cervical squamous cell carcinoma aerobic glycolysis progression.	hsa_circ_0008796	circCDKN2B-AS1	hsa_circ_CDKN2B-AS1	CDKN2B-AS1	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; RNA-seq	"circCDKN2B-AS1 is up-regulated in cervical cancer/HSIL and acts as an oncogenic circRNA. It binds the RBP IMP3 to enhance IMP3 association with the HK2 mRNA 3¡äUTR, stabilizing HK2 mRNA and promoting aerobic glycolysis, proliferation, migration/invasion and tumor growth in vitro and in vivo."	0.8705
33311442	Cell death & disease	2020	CircRNA hsa_circRNA_104348 promotes hepatocellular carcinoma progression through modulating miR-187-3p/RTKN2 axis and activating Wnt/beta-catenin pathway.		hsa_circRNA_104348 	hsa_circ_ELMO1	ELMO1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"hsa_circRNA_104348 (has_circ_104348) is up-regulated in hepatocellular carcinoma tissues and cell lines and is associated with worse overall survival. Functionally, it promotes HCC cell proliferation, migration, invasion and EMT-like changes while inhibiting apoptosis, and its knockdown suppresses tumor growth and lung metastasis in xenograft models. Mechanistically, it mainly localizes to the cytoplasm and acts as a ceRNA sponging miR-187-3p to increase RTKN2 and activate Wnt/beta-catenin signaling."	0.8428
33312754	Molecular therapy. Nucleic acids	2020	circEYA1 Functions as a Sponge of miR-582-3p to Suppress Cervical Adenocarcinoma Tumorigenesis via Upregulating CXCL14.	hsa_circ_0137084	circEYA1 	hsa_circ_EYA1	EYA1	cervical adenocarcinoma	MONDO:0005153	cervical adenocarcinoma	down-regulated	RT-qPCR; RNA-seq	"circEYA1 (hsa_circ_0137084), derived from EYA1, is down-regulated in cervical adenocarcinoma and acts as a tumor suppressor. It sponges miR-582-3p in the nucleus and cytoplasm to relieve repression of CXCL14, thereby inhibiting proliferation/colony formation and promoting apoptosis, including in a HeLa xenograft model. Clinically, circEYA1 shows diagnostic potential (ROC AUC 0.814) and was validated in a cohort of 198 cervical tissue samples."	0.8769
33312757	Molecular therapy. Nucleic acids	2021	circRASGRF2 functions as an oncogenic gene in hepatocellular carcinoma by acting as a miR-1224 sponge.	hsa_circ_0073181	circRASGRF2	hsa_circ_RASGRF2	RASGRF2	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circRASGRF2 (hsa_circ_0073181) is upregulated in HCC and primarily localized in the cytoplasm. It promotes HCC cell proliferation, migration/invasion, EMT, and tumor growth/metastasis by sponging miR-1224 to derepress FAK, and high expression is associated with poor overall survival and diagnostic value (AUC 0.882)."	0.898
33312941	Frontiers in oncology	2020	Circular RNA Circ-03955 Promotes Epithelial-Mesenchymal Transition in Osteosarcoma by Regulating miR-3662/Metadherin Pathway.		Circ-03955 			osteosarcoma	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"circ-03955 is up-regulated in osteosarcoma tissues/cells and mainly localizes to the cytoplasm. It promotes osteosarcoma progression and EMT by sponging miR-3662 and indirectly increasing MTDH expression, thereby enhancing proliferation/migration/invasion and suppressing apoptosis."	0.8254
33313118	Annals of translational medicine	2020	Integrated analysis of circRNA-miRNA-mRNA network reveals potential prognostic biomarkers for radiotherapies with X-rays and carbon ions in non-small cell lung cancer.	hsa_circ_0084606				non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0084606 was identified as differentially expressed in the radioresistance-related circRNA profiling of NSCLC cell lines, but its direction of change was inconsistent between RNA-seq and RT-qPCR validation."	0.2465
33313120	Annals of translational medicine	2020	Comprehensive analysis of circular RNA in oral leukoplakia: upregulated circHLA-C as a potential biomarker for diagnosis and prognosis.		circHLA-C	hsa_circ_HLA-C	HLA-C	oral leukoplakia 	MONDO:0004844	oral mucosa leukoplakia	up-regulated	RT-qPCR; RNA-seq	"circHLA-C is up-regulated in oral leukoplakia tissues and its expression positively correlates with the degree of epithelial dysplasia. It shows strong diagnostic potential (ROC AUC 0.9550) and is proposed to act via a predicted miRNA-sponge (ceRNA) mechanism involving miR-9, miR-339-5p, miR-29a-3p, miR-26a-5p, and miR-222-3p."	0.6841
33313120	Annals of translational medicine	2020	Comprehensive analysis of circular RNA in oral leukoplakia: upregulated circHLA-C as a potential biomarker for diagnosis and prognosis.		circPLIN4	hsa_circ_PLIN4	PLIN4	oral leukoplakia 	MONDO:0004844	oral mucosa leukoplakia	up-regulated	RT-qPCR; RNA-seq	"circPLIN4 is significantly up-regulated in OLK versus NOM and its expression change is consistent between RNA-seq and RT-qPCR validation. The study further shows circPLIN4 is RNase R-resistant, supporting its circular nature, but does not report a specific functional mechanism in OLK."	0.5541
33313120	Annals of translational medicine	2020	Comprehensive analysis of circular RNA in oral leukoplakia: upregulated circHLA-C as a potential biomarker for diagnosis and prognosis.		circMTX2	hsa_circ_MTX2	MTX2	oral leukoplakia 	MONDO:0004844	oral mucosa leukoplakia	up-regulated	RT-qPCR; RNA-seq	circMTX2 is significantly up-regulated in OLK versus NOM with consistent direction between RNA-seq and RT-qPCR. The paper does not provide a specific functional mechanism or clinical utility for circMTX2 beyond differential expression validation.	0.4773
33313120	Annals of translational medicine	2020	Comprehensive analysis of circular RNA in oral leukoplakia: upregulated circHLA-C as a potential biomarker for diagnosis and prognosis.		circRNF13	hsa_circ_RNF13	RNF13	oral leukoplakia 	MONDO:0004844	oral mucosa leukoplakia	up-regulated	RT-qPCR; RNA-seq	"circRNF13 is up-regulated in OLK and validated by RT-qPCR. It is RNase R-resistant and was included in the constructed ceRNA network with predicted binding to miR-7-5p, miR-5683, miR-7107-3p, miR-4452, and miR-580-5p, but downstream effects were not experimentally tested."	0.6193
33313120	Annals of translational medicine	2020	Comprehensive analysis of circular RNA in oral leukoplakia: upregulated circHLA-C as a potential biomarker for diagnosis and prognosis.		circSENP2	hsa_circ_SENP2	SENP2	oral leukoplakia 	MONDO:0004844	oral mucosa leukoplakia	down-regulated	RT-qPCR; RNA-seq	"circSENP2 is significantly down-regulated in OLK compared with NOM and was validated by RT-qPCR with the same trend as RNA-seq. No further mechanism, pathway, or clinical application is reported for circSENP2 in this study."	0.4773
33313120	Annals of translational medicine	2020	Comprehensive analysis of circular RNA in oral leukoplakia: upregulated circHLA-C as a potential biomarker for diagnosis and prognosis.		circPLEKHM2	hsa_circ_PLEKHM2	PLEKHM2	oral leukoplakia 	MONDO:0004844	oral mucosa leukoplakia	down-regulated	RT-qPCR; RNA-seq	circPLEKHM2 is significantly down-regulated in OLK versus NOM and was validated by RT-qPCR consistent with RNA-seq. The study does not report specific downstream mechanisms or clinical relevance for circPLEKHM2.	0.4773
33313120	Annals of translational medicine	2020	Comprehensive analysis of circular RNA in oral leukoplakia: upregulated circHLA-C as a potential biomarker for diagnosis and prognosis.		circEMB	hsa_circ_EMB	EMB	oral leukoplakia 	MONDO:0004844	oral mucosa leukoplakia	down-regulated	RT-qPCR; RNA-seq	circEMB is significantly down-regulated in OLK compared with NOM and validated by RT-qPCR consistent with RNA-seq. No additional mechanism or clinical significance is provided for circEMB in this paper.	0.4773
33313951	Molecular medicine reports	2021	circARRDC3 contributes to interleukin_13_induced inflammatory cytokine and mucus production in nasal epithelial cells via the miR_375/KLF4 axis.		circARRDC3	hsa_circ_ARRDC3	ARRDC3	allergic rhinitis 	MONDO:0011786	allergic rhinitis	up-regulated	RT-qPCR	"circARRDC3 is up-regulated in AR nasal mucosa and promotes IL-13-induced inflammatory cytokine (GM-CSF, eotaxin) and mucus (MUC5AC) production in nasal epithelial cells. Mechanistically, circARRDC3 negatively regulates miR-375, thereby increasing KLF4 and driving AR-associated inflammatory responses."	0.7078
33314480	Cancer science	2021	circ_100984-miR-432-3p axis regulated c-Jun/YBX-1/beta-catenin feedback loop promotes bladder cancer progression.		circ_100984			bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circ_100984 is up-regulated in bladder cancer tissues and cell lines and promotes tumor growth, migration, invasion, metastasis, and EMT. It functions as a ceRNA by sponging miR-432-3p to derepress YBX-1, thereby facilitating a c-Jun/YBX-1/beta-catenin feedback loop that supports malignant progression."	0.6833
33314661	International wound journal	2021	Identification of potential circRNAs and circRNA-miRNA-mRNA regulatory network in the development of diabetic foot ulcers by integrated bioinformatics analysis.		circRNA_072697 			diabetic foot ulcers 	MONDO:0000960	diabetic peripheral angiopathy	up-regulated	RT-qPCR; Microarray	"In DFU, circRNA_072697 is up-regulated and may function as a ceRNA by sponging miR-3150a-3p to regulate KRAS, with MAPK signaling implicated as a related pathway. It is proposed as a novel biomarker for DFU."	0.5135
33314661	International wound journal	2021	Identification of potential circRNAs and circRNA-miRNA-mRNA regulatory network in the development of diabetic foot ulcers by integrated bioinformatics analysis.		circRNA_405463 			diabetic foot ulcers 	MONDO:0000960	diabetic peripheral angiopathy	unknown	Microarray	"circRNA_405463 was identified as a differentially expressed circRNA in DFU and predicted to bind miR-4649-3p with analyzed binding sites. It was proposed as a potential biomarker for DFU, but its expression direction and downstream targets were not experimentally validated in this paper."	0.329
33316781	Aging	2020	Circ_0005198 enhances temozolomide resistance of glioma cells through miR-198/TRIM14 axis.	hsa_circ_0005198	circ_0005198 			glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR	circ_0005198 is up-regulated in glioma tissues/serum and further increased in TMZ-resistant glioma cells. It localizes mainly in the cytoplasm and promotes TMZ resistance and malignant phenotypes by sponging miR-198 and derepressing TRIM14 (circ_0005198/miR-198/TRIM14 axis).	0.7283
33317596	Journal of experimental & clinical cancer research : CR	2020	CircRNA_0000392 promotes colorectal cancer progression through the miR-193a-5p/PIK3R3/AKT axis.	hsa_circ_0000392	circRNA_0000392 	hsa_circ_YAF2	YAF2	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"circRNA_0000392 is up-regulated in colorectal cancer and promotes malignant phenotypes (proliferation, invasion, tumor growth). It mainly localizes to the cytoplasm and acts as a ceRNA by sponging miR-193a-5p, thereby increasing PIK3R3 and activating the AKT/mTOR pathway."	0.8768
33318568	Scientific reports	2020	The bivariate NRIP1/ZEB2 RNA marker permits non-invasive presymptomatic screening of pre-eclampsia.		circular NRIP1 	hsa_circ_NRIP1	NRIP1	pre-eclampsia	MONDO:0005081	preeclampsia	dysregulated	RT-qPCR	This study detected and quantified circular NRIP1 in first-trimester maternal plasma and used the relative balance between linear and circular NRIP1 to help discriminate pre-eclampsia from trisomy 21 in presymptomatic screening. No downstream miRNA/protein/pathway mechanism for circNRIP1 was experimentally established in this paper.	0.429
33320427	Journal of cellular and molecular medicine	2022	Circular RNA hsa_circ_0008003 facilitates tumorigenesis and development of non-small cell lung carcinoma via modulating miR-488/ZNF281 axis.	hsa_circ_0008003	circ_0008003			non_small cell lung carcinoma 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0008003 (circ-0008003) is up-regulated in NSCLC tissues and cell lines and promotes proliferation, invasion, and xenograft tumor growth. Mechanistically, it acts as a cytoplasmic ceRNA that sponges miR-488 to increase ZNF281 expression. High circ-0008003 level is associated with advanced TNM stage/lymphatic metastasis and predicts poor survival."	0.8581
33320435	Journal of cellular and molecular medicine	2021	CircPUM1 promotes hepatocellular carcinoma progression through the miR-1208/MAP3K2 axis.	hsa_circ_0000043	circPUM1 	hsa_circ_PUM1	PUM1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	unknown	RT-qPCR	"circPUM1 functions as an oncogenic circRNA in HCC, promoting proliferation, migration, invasion and EMT. Mechanistically, it sponges miR-1208 to de-repress MAP3K2, and circPUM1 knockdown suppresses xenograft tumor growth with reduced EMT markers."	0.7002
33323543	Aging	2020	Screening and functional prediction of differentially expressed circular RNAs in human glioma of different grades.	hsa_circ_0000915	hsa_circFKBP8_005	hsa_circ_FKBP8	FKBP8	glioma 	MONDO:0021042	glioma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000915 is down-regulated in HGG compared with LGG and shows diagnostic potential by ROC analysis. The study predicts it may participate in a circRNA_miRNA_mRNA network (e.g., via hsa-miR-330-5p and FAIM2) but does not functionally validate downstream effects."	0.6556
33323543	Aging	2020	Screening and functional prediction of differentially expressed circular RNAs in human glioma of different grades.	hsa_circ_0127664	hsa_circKCNN2_003	hsa_circ_KCNN2	KCNN2	glioma 	MONDO:0021042	glioma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0127664 is down-regulated in HGG compared with LGG and has diagnostic potential by ROC analysis. The study predicts a circRNA_miRNA_mRNA network (e.g., via hsa-miR-99b-3p and DLGAP2) and reports relatively high predicted m6A modification, without functional experiments."	0.6556
33323543	Aging	2020	Screening and functional prediction of differentially expressed circular RNAs in human glioma of different grades.	hsa_circ_0008362	hsa_circFBXW4_008	hsa_circ_FBXW4	FBXW4	glioma 	MONDO:0021042	glioma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0008362 is down-regulated in HGG compared with adjacent normal tissue and shows strong diagnostic potential by ROC analysis. The study predicts a ceRNA network (e.g., via hsa-miR-217-5p and ATP1B1) and relatively high predicted m6A modification, without functional validation."	0.6556
33323543	Aging	2020	Screening and functional prediction of differentially expressed circular RNAs in human glioma of different grades.	hsa_circ_0001467	hsa_circMARCH6_047	hsa_circ_MARCH6	MARCH6	glioma 	MONDO:0021042	glioma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001467 is down-regulated in HGG compared with adjacent normal tissue and shows strong diagnostic potential by ROC analysis. The study predicts a ceRNA network (e.g., via hsa-miR-302d-5p and RALYL) and suggests coding potential via predicted IRES/ORF, without functional validation."	0.6556
33324055	International journal of nanomedicine	2020	Hsa_circ_0000069 Knockdown Inhibits Tumorigenesis and Exosomes with Downregulated hsa_circ_0000069 Suppress Malignant Transformation via Inhibition of STIL in Pancreatic Cancer.	hsa_circ_0000069		hsa_circ_STIL	STIL	pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000069 is upregulated in pancreatic cancer and functions as an oncogenic circRNA. It sponges miR-144 to upregulate STIL (with effects on GLi1 and cell-cycle regulators), promoting proliferation, migration/invasion and cell-cycle progression while suppressing apoptosis. SW1990-derived exosomes can transfer hsa_circ_0000069 to HPDE cells, and reducing exosomal hsa_circ_0000069 suppresses HPDE malignant transformation."	0.7861
33324096	Cancer management and research	2020	CircRNA_102272 Promotes Cisplatin-Resistance in Hepatocellular Carcinoma by Decreasing MiR-326 Targeting of RUNX2.		circRNA_102272 			hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circRNA_102272 is up-regulated in HCC and is associated with worse patient survival. It promotes HCC cell proliferation and cisplatin resistance by acting as a ceRNA that sponges miR-326, thereby increasing RUNX2 expression."	0.7325
33328224	Science advances	2020	The nuclear DICER-circular RNA complex drives the deregulation of the glioblastoma cell microRNAome.	hsa_circ_0002082		hsa_circ_MALAT1	MALAT1	glioblastoma 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; ISH; Microarray	"circ2082 (hsa_circ_0002082), derived from MALAT1, is up-regulated in glioblastoma GSCs and forms a nuclear complex with RBM3 and DICER. This complex retains DICER in the nucleus and contributes to impaired microRNA maturation and microRNAome suppression; circ2082 knockdown relocalizes DICER to the cytosol, restores the microRNAome, and reduces tumorigenicity in vitro and in xenograft models, with links to favorable patient outcomes."	0.8208
33328759	International journal of general medicine	2020	Circular RNA 0001313 Knockdown Suppresses Non-Small Cell Lung Cancer Cell Proliferation and Invasion via the microRNA-452/HMGB3/ERK/MAPK Axis.	hsa_circ_0001313		hsa_circ_CCDC66	CCDC66	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ0001313 is up-regulated in NSCLC tissues and cell lines and promotes proliferation and invasion. Mechanistically, it sponges miR-452 to increase HMGB3 expression, leading to ERK/MAPK pathway activation."	0.7477
33329702	Frontiers in genetics	2020	Integrative Analysis Extracts a Core ceRNA Network of the Fetal Hippocampus With Down Syndrome.	hsa_circ_0078328				Down syndrome 	MONDO:0008608	Down syndrome	unknown	RT-qPCR; Microarray	"In fetal hippocampus Down syndrome samples, hsa_circ_0078328 is implicated as a ceRNA that directly binds miR-138-5p and may modulate EZH2, potentially influencing hippocampal development. The circRNA_miRNA interaction was supported by dual-luciferase assay in 293T cells."	0.5618
33329702	Frontiers in genetics	2020	Integrative Analysis Extracts a Core ceRNA Network of the Fetal Hippocampus With Down Syndrome.	hsa_circ_0115770		hsa_circ_GRIK1	GRIK1	Down syndrome 	MONDO:0008608	Down syndrome	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_0115770 is an upregulated GRIK1-derived circRNA in fetal hippocampus from Down syndrome cases. The study proposes it participates in a multidimensional circRNA_miRNA_mRNA network potentially relevant to abnormal neurodevelopment, with expression validated by qRT-PCR."	0.3588
33329702	Frontiers in genetics	2020	Integrative Analysis Extracts a Core ceRNA Network of the Fetal Hippocampus With Down Syndrome.	hsa_circ_0115774		hsa_circ_GRIK1	GRIK1	Down syndrome 	MONDO:0008608	Down syndrome	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_0115774 is an upregulated GRIK1-derived circRNA in fetal hippocampus from Down syndrome cases. The study suggests it may contribute to abnormal neurodevelopment through a predicted circRNA_miRNA_mRNA network, with expression validated by qRT-PCR."	0.3588
33329702	Frontiers in genetics	2020	Integrative Analysis Extracts a Core ceRNA Network of the Fetal Hippocampus With Down Syndrome.	hsa_circ_0115775		hsa_circ_GRIK1	GRIK1	Down syndrome 	MONDO:0008608	Down syndrome	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_0115775 is an upregulated GRIK1-derived circRNA in fetal hippocampus from Down syndrome cases. The paper associates it with a predicted circRNA_miRNA_mRNA network potentially linked to abnormal neurodevelopment, and indicates qRT-PCR expression validation was performed for circ-GRIK1s."	0.3588
33330021	Frontiers in oncology	2020	Expression Profile of Circular RNAs in Oral Squamous Cell Carcinoma.	hsa_circ_0005050		hsa_circ_XPO1	XPO1	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	unknown	RT-qPCR; RNA-seq	hsa_circ_0005050 (from host gene XPO1) was identified as a differentially expressed circRNA in OSCC tissues versus normal oral mucosa and was validated/confirmed as circular by RNase R treatment and Sanger sequencing; no specific downstream miRNA/target axis or functional phenotype was established for this circRNA in this study.	0.5841
33330021	Frontiers in oncology	2020	Expression Profile of Circular RNAs in Oral Squamous Cell Carcinoma.	hsa_circ_0001766		hsa_circ_PDIA4	PDIA4	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001766 (from PDIA4) is upregulated in OSCC tissues and OSCC cell lines. Functionally, its knockdown suppresses OSCC cell proliferation. Mechanistically, it likely acts as a ceRNA that sponges miR-877-3p to increase VEGFA expression, and miR-877-3p inhibition rescues the effects of hsa_circ_0001766 knockdown."	0.7754
33330483	Frontiers in cell and developmental biology	2020	"CircASH2L Promotes Ovarian Cancer Tumorigenesis, Angiogenesis, and Lymphangiogenesis by Regulating the miR-665/VEGFA Axis as a Competing Endogenous RNA."		circASH2L 	hsa_circ_ASH2L	ASH2L	ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circASH2L is up-regulated in ovarian cancer tissues and cell lines and acts as an oncogenic circRNA. It mainly localizes to the cytoplasm and functions as a ceRNA to sponge miR-665, thereby increasing VEGFA expression and promoting proliferation, invasion, as well as VEGFA-mediated angiogenesis and lymphangiogenesis in vitro and in xenograft tumors."	0.8174
33330659	Frontiers in cardiovascular medicine	2020	Expression Profiles of Circular RNA in Human Atrial Fibrillation With Valvular Heart Diseases.		circ 255-ITGA7	hsa_circ_ITGA7	ITGA7	atrial fibrillation 	MONDO:0004981	atrial fibrillation	down-regulated	RT-qPCR; RNA-seq	"circ 255-ITGA7 is significantly down-regulated in left atrial appendage tissue from VHD patients with persistent AF compared with sinus rhythm controls. The study validates its differential expression by RT-qPCR and confirms its back-splice junction by Sanger sequencing, but does not define a specific miRNA/mRNA axis for this circRNA."	0.5541
33330659	Frontiers in cardiovascular medicine	2020	Expression Profiles of Circular RNA in Human Atrial Fibrillation With Valvular Heart Diseases.		circ 418-KCNN2	hsa_circ_KCNN2	KCNN2	atrial fibrillation 	MONDO:0004981	atrial fibrillation	down-regulated	RT-qPCR; RNA-seq	"circ 418-KCNN2 is down-regulated in valvular persistent AF LAA tissue. Network analysis suggests it may act via a ceRNA-like mechanism affecting the miR-302a/b/c/d-3p cluster to regulate RELA (p65), implicating inflammatory/NF-kappaB-related signaling in AF."	0.585
33330659	Frontiers in cardiovascular medicine	2020	Expression Profiles of Circular RNA in Human Atrial Fibrillation With Valvular Heart Diseases.		circ 13913-MIB1	hsa_circ_MIB1	MIB1	atrial fibrillation 	MONDO:0004981	atrial fibrillation	down-regulated	RT-qPCR; RNA-seq	"circ 13913-MIB1 is significantly down-regulated in LAA tissue from VHD patients with persistent AF. The study confirms differential expression by RT-qPCR and validates its back-splice junction by Sanger sequencing, but does not report a specific downstream miRNA/mRNA mechanism for this circRNA."	0.5541
33330659	Frontiers in cardiovascular medicine	2020	Expression Profiles of Circular RNA in Human Atrial Fibrillation With Valvular Heart Diseases.		circ 44670-BARD1	hsa_circ_BARD1	BARD1	atrial fibrillation 	MONDO:0004981	atrial fibrillation	up-regulated	RT-qPCR; RNA-seq	"circ 44670-BARD1 is up-regulated in LAA tissue from VHD patients with persistent AF versus sinus rhythm. Its differential expression is validated by RT-qPCR and its back-splice junction is confirmed by Sanger sequencing, but no specific miRNA/mRNA axis is provided for this circRNA."	0.5541
33330659	Frontiers in cardiovascular medicine	2020	Expression Profiles of Circular RNA in Human Atrial Fibrillation With Valvular Heart Diseases.		circ 44782-LAMA2	hsa_circ_LAMA2	LAMA2	atrial fibrillation 	MONDO:0004981	atrial fibrillation	up-regulated	RT-qPCR; RNA-seq	"circ 44782-LAMA2 is up-regulated in LAA tissue from VHD patients with persistent AF. The study validates its differential expression via RT-qPCR and confirms its back-splice junction by Sanger sequencing, but does not report a specific downstream regulatory axis for this circRNA."	0.5541
33330659	Frontiers in cardiovascular medicine	2020	Expression Profiles of Circular RNA in Human Atrial Fibrillation With Valvular Heart Diseases.		circ 81906-RYR2	hsa_circ_RYR2	RYR2	atrial fibrillation 	MONDO:0004981	atrial fibrillation	up-regulated	RT-qPCR; RNA-seq	circ 81906-RYR2 is up-regulated in valvular persistent AF LAA tissue. The constructed network predicts a circ 81906-RYR2/miR-7-5p/CALM2/3 axis that may relate to calcium signaling and cAMP-associated pathways in AF.	0.585
33330659	Frontiers in cardiovascular medicine	2020	Expression Profiles of Circular RNA in Human Atrial Fibrillation With Valvular Heart Diseases.		circ 35880-ANO5	hsa_circ_ANO5	ANO5	atrial fibrillation 	MONDO:0004981	atrial fibrillation	up-regulated	RT-qPCR; RNA-seq	"circ 35880-ANO5 is up-regulated in LAA tissue from VHD patients with persistent AF compared with sinus rhythm. The association is supported by RNA-seq and validated by RT-qPCR, with back-splice junction confirmed by Sanger sequencing, but no specific mechanistic axis is described for this circRNA."	0.5541
33330659	Frontiers in cardiovascular medicine	2020	Expression Profiles of Circular RNA in Human Atrial Fibrillation With Valvular Heart Diseases.		circ 22249-TNNI3K	hsa_circ_TNNI3K	TNNI3K	atrial fibrillation 	MONDO:0004981	atrial fibrillation	up-regulated	RT-qPCR; RNA-seq	"circ 22249-TNNI3K is up-regulated in LAA tissue from VHD patients with persistent AF. Differential expression is validated by RT-qPCR and junction confirmation by Sanger sequencing, but the study does not report a specific miRNA/mRNA regulatory mechanism for this circRNA."	0.5541
33330659	Frontiers in cardiovascular medicine	2020	Expression Profiles of Circular RNA in Human Atrial Fibrillation With Valvular Heart Diseases.		circ 3136-TNNI3K	hsa_circ_TNNI3K	TNNI3K	atrial fibrillation 	MONDO:0004981	atrial fibrillation	up-regulated	RT-qPCR; RNA-seq	"circ 3136-TNNI3K is up-regulated in valvular persistent AF LAA tissue and is among six circRNAs used to build the circRNA-miRNA-mRNA interaction network. Downstream genes in the network are enriched for cAMP and Wnt signaling pathways, suggesting circ 3136-TNNI3K may be involved in these AF-related pathways via predicted ceRNA regulation."	0.585
33330659	Frontiers in cardiovascular medicine	2020	Expression Profiles of Circular RNA in Human Atrial Fibrillation With Valvular Heart Diseases.		circ 56186-TNNI3K	hsa_circ_TNNI3K	TNNI3K	atrial fibrillation 	MONDO:0004981	atrial fibrillation	up-regulated	RT-qPCR; RNA-seq	"circ 56186-TNNI3K is up-regulated in valvular persistent AF LAA tissue compared with sinus rhythm. The study validates its differential expression by RT-qPCR and confirms its back-splice junction by Sanger sequencing, but does not report a specific regulatory axis for this circRNA."	0.5541
33335404	OncoTargets and therapy	2020	A Circular RNA Derived from Golgi Glycoprotein 1 mRNA Regulates KRAS Expression and Promotes Colorectal Cancer Progression by Targeting microRNA-622.	hsa_circ_0003315	circ_GLG1	hsa_circ_GLG1	GLG1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circ_GLG1 is up-regulated in colorectal cancer tissues and CRC cell lines and acts as an oncogenic circRNA. It sponges miR-622 to increase KRAS expression (mRNA and protein), thereby promoting CRC cell proliferation, viability, invasion, and migration in vitro."	0.6829
33335643	Oxidative medicine and cellular longevity	2020	Oxidative Stress-Induced circHBEGF Promotes Extracellular Matrix Production via Regulating miR-646/EGFR in Human Trabecular Meshwork Cells.	hsa_circ_0074241	circHBEGF	hsa_circ_HBEGF	HBEGF	primary open-angle glaucoma 	MONDO:0005338	open-angle glaucoma	up-regulated	RT-qPCR; Microarray	"In oxidative stress-treated human trabecular meshwork cells (a POAG-relevant model), circHBEGF is up-regulated and promotes extracellular matrix accumulation. Mechanistically, it sponges miR-646 to de-repress EGFR and activate downstream STAT3/AKT/ERK signaling, leading to increased fibronectin and collagen I expression."	0.5871
33336052	"Open medicine (Warsaw, Poland)"	2020	Circular RNA circ_SETD2 represses breast cancer progression via modulating the miR-155-5p/SCUBE2 axis.	hsa_circ_0065173	circ_SETD2	hsa_circ_SETD2	SETD2	Breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	"circ_SETD2 is down-regulated in breast cancer and functions as a tumor suppressor. It sponges miR-155-5p to increase SCUBE2, thereby inhibiting proliferation/migration/invasion, arresting the cell cycle, promoting apoptosis, and suppressing xenograft tumor growth."	0.7799
33336062	"Open medicine (Warsaw, Poland)"	2020	"Circular RNA hsa_circ_0007121 regulates proliferation, migration, invasion, and epithelial-mesenchymal transition of trophoblast cells by miR-182-5p/PGF axis in preeclampsia."	hsa_circ_0007121				preeclampsia 	MONDO:0005081	preeclampsia	down-regulated	RT-qPCR	"hsa_circ_0007121 is down-regulated in PE placental tissues and in HTR-8/SVneo trophoblast cells. Functionally, increased hsa_circ_0007121 promotes trophoblast proliferation, migration, invasion and EMT, while its knockdown suppresses these processes. Mechanistically, it sponges miR-182-5p to derepress PGF (hsa_circ_0007121/miR-182-5p/PGF axis)."	0.7911
33344445	Frontiers in cell and developmental biology	2020	CircAMOTL1 Promotes Tumorigenesis Through miR-526b/SIK2 Axis in Cervical Cancer.	hsa_circ_0004214		hsa_circ_AMOTL1	AMOTL1	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"CircAMOTL1 is up-regulated in cervical cancer tissues and cell lines and promotes proliferation, migration/invasion, EMT, tumorigenicity and metastasis while inhibiting apoptosis. Mechanistically, it functions as a ceRNA by sponging miR-526b to increase SIK2 expression and enhance AKT signaling/EMT."	0.7418
33347535	Carcinogenesis	2021	Hsa_circRNA_002144 promotes growth and metastasis of colorectal cancer through regulating miR-615-5p/LARP1/mTOR pathway.		hsa_circRNA_002144 	hsa_circ_RPPH1	RPPH1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_002144 is up-regulated in colorectal cancer tissues and cell lines and is associated with shorter overall survival. Functionally, it promotes CRC growth, metastasis and EMT while inhibiting apoptosis, mainly by sponging miR-615-5p to increase LARP1 and mTOR expression."	0.8192
33356989	Technology in cancer research & treatment	2020	Hsa_circ_0075960 Serves as a Sponge for miR-361-3p/SH2B1 in Endometrial Carcinoma.	hsa_circ_0075960	circ_0075960			endometrial carcinoma 	MONDO:0002447	endometrial carcinoma	up-regulated	RT-qPCR	"hsa_circ_0075960 is upregulated in endometrial carcinoma cell lines and promotes malignant phenotypes (increased proliferation and migration, reduced apoptosis). Mechanistically, it acts as a ceRNA sponge for miR-361-3p to increase SH2B1 expression, and miR-361-3p inhibition reverses the effects of hsa_circ_0075960 knockdown."	0.7198
33361760	Signal transduction and targeted therapy	2020	CircRNA-SORE mediates sorafenib resistance in hepatocellular carcinoma by stabilizing YBX1.	hsa_circ_0087293	circRNA-SORE 	hsa_circ_TLE4	TLE4	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circRNA-SORE (circRNA_104797/circ_0087293) is up-regulated in sorafenib-resistant HCC cells and promotes sorafenib resistance by inhibiting sorafenib-induced apoptosis. Mechanistically, it binds YBX1 in the cytoplasm to prevent PRP19-mediated ubiquitination and degradation of YBX1, and it can be transported via exosomes to spread resistance among HCC cells; high circRNA-SORE predicts worse recurrence-free survival in sorafenib-treated patients."	0.8792
33363013	Frontiers in oncology	2020	CircRNA_ACAP2 Suppresses EMT in Head and Neck Squamous Cell Carcinoma by Targeting the miR-21-5p/STAT3 Signaling Axis.		CircRNA_ACAP2 	hsa_circ_ACAP2	ACAP2	head and neck squamous cell carcinoma 	MONDO:0010150	head and neck squamous cell carcinoma	down-regulated	RT-qPCR	"CircRNA_ACAP2 is down-regulated in HNSCC and acts as a tumor suppressor. It primarily localizes to the cytoplasm and inhibits EMT-related behaviors (proliferation, migration/invasion) by sponging miR-21-5p to modulate STAT3 signaling and downstream ZEB1, and higher expression is associated with better overall survival."	0.7696
33363156	Frontiers in cell and developmental biology	2020	An Eight-CircRNA Assessment Model for Predicting Biochemical Recurrence in Prostate Cancer.		circ_30029	hsa_circ_STK39	STK39	prostate cancer 	MONDO:0008315	prostate cancer	unknown	RNA-seq	"circ_30029 is one component of an eight-circRNA signature that predicts biochemical recurrence in prostate cancer. In the model, its negative coefficient indicates that higher circ_30029 expression is associated with reduced biochemical recurrence risk."	0.5504
33363156	Frontiers in cell and developmental biology	2020	An Eight-CircRNA Assessment Model for Predicting Biochemical Recurrence in Prostate Cancer.		circ_117300	hsa_circ_MKLN1	MKLN1	prostate cancer 	MONDO:0008315	prostate cancer	unknown	RNA-seq	circ_117300 contributes to an eight-circRNA signature for predicting biochemical recurrence in prostate cancer. Its negative model coefficient suggests higher expression associates with longer BCR-free outcome.	0.5504
33363156	Frontiers in cell and developmental biology	2020	An Eight-CircRNA Assessment Model for Predicting Biochemical Recurrence in Prostate Cancer.		circ_176436	hsa_circ_SLC22A3	SLC22A3	prostate cancer 	MONDO:0008315	prostate cancer	unknown	RNA-seq	"circ_176436 is included in an eight-circRNA signature for predicting biochemical recurrence in prostate cancer. Within the model, higher circ_176436 expression is associated with reduced recurrence risk."	0.5504
33363156	Frontiers in cell and developmental biology	2020	An Eight-CircRNA Assessment Model for Predicting Biochemical Recurrence in Prostate Cancer.		circ_112897	hsa_circ_ACSM1	ACSM1	prostate cancer 	MONDO:0008315	prostate cancer	unknown	RNA-seq	circ_112897 is part of an eight-circRNA model predicting biochemical recurrence in prostate cancer. Higher circ_112897 expression corresponds to a lower recurrence risk in the model.	0.5504
33363156	Frontiers in cell and developmental biology	2020	An Eight-CircRNA Assessment Model for Predicting Biochemical Recurrence in Prostate Cancer.		circ_178252	hsa_circ_ASPH	ASPH	prostate cancer 	MONDO:0008315	prostate cancer	unknown	RNA-seq	circ_178252 is a component of an eight-circRNA signature predicting biochemical recurrence in prostate cancer. Higher circ_178252 expression is associated with worse BCR-related outcome in the model.	0.5504
33363156	Frontiers in cell and developmental biology	2020	An Eight-CircRNA Assessment Model for Predicting Biochemical Recurrence in Prostate Cancer.		circ_115617	hsa_circ_PTPN13	PTPN13	prostate cancer 	MONDO:0008315	prostate cancer	unknown	RNA-seq	circ_115617 is an element of an eight-circRNA prognostic signature for biochemical recurrence in prostate cancer. Higher circ_115617 expression is linked to worse BCR outcome in the model.	0.5504
33363156	Frontiers in cell and developmental biology	2020	An Eight-CircRNA Assessment Model for Predicting Biochemical Recurrence in Prostate Cancer.		circ_14736	hsa_circ_OMA1	OMA1	prostate cancer 	MONDO:0008315	prostate cancer	unknown	RT-qPCR; RNA-seq	"circ_14736 is included in an eight-circRNA signature predicting biochemical recurrence in prostate cancer, where higher expression indicates worse outcome. Experimentally, circ_14736 shows circular features, is mainly cytoplasmic, promotes proliferation of PCa cells, and can be detected in plasma exosomes from PCa patients."	0.8209
33363156	Frontiers in cell and developmental biology	2020	An Eight-CircRNA Assessment Model for Predicting Biochemical Recurrence in Prostate Cancer.		circ_17720	hsa_circ_RERE	RERE	prostate cancer 	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; RNA-seq	"circ_17720 is part of an eight-circRNA model for predicting biochemical recurrence in prostate cancer, where higher expression is associated with less recurrence. Experimentally, it is downregulated in PCa cell lines, mainly localized in the cytoplasm, supports PCa cell proliferation, and is detectable in patient plasma exosomes; its downstream mechanism was not validated, though database-based miRNA/protein binding and coding potential were reported."	0.8209
33363164	Frontiers in cell and developmental biology	2020	The Involvement of the hsa_circ_0088494-miR-876-3p-CTNNB1/CCND1 Axis in Carcinogenesis and Progression of Papillary Thyroid Carcinoma.	hsa_circ_0088494	hsa_circRNA_104917	hsa_circ_NEK6	NEK6	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circ_0088494 is up-regulated in papillary thyroid carcinoma and is proposed to act in a ceRNA axis by negatively associating with miR-876-3p and positively associating with CTNNB1 and CCND1. This hsa_circ_0088494_miR-876-3p_CTNNB1/CCND1 regulatory axis is linked to PTC carcinogenesis and progression.	0.4032
33364827	Cancer management and research	2020	Hsa_circ_0046263 Drives the Carcinogenesis and Metastasis of Non-Small Cell Lung Cancer Through the Promotion of NOVA2 by Absorbing Mir-940 as a Molecular Sponge.	hsa_circ_0046263	circP4HB	hsa_circ_P4HB	P4HB	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0046263 is up-regulated in NSCLC and acts as an oncogenic circRNA. It sponges miR-940 to relieve repression of NOVA2, thereby promoting proliferation, cell-cycle progression, migration/invasion and in vivo tumor growth while inhibiting apoptosis, and high expression predicts poorer survival."	0.8299
33364834	Cancer management and research	2020	Circ-PRKDC Facilitates the Progression of Colorectal Cancer Through miR-198/DDR1 Regulatory Axis.	hsa_circ_0136666	circ-PRKDC	hsa_circ_PRKDC	PRKDC	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ-PRKDC (hsa_circ_0136666) is up-regulated in colorectal cancer and promotes malignant phenotypes (proliferation, migration, invasion) while inhibiting apoptosis and facilitating tumor growth. Mechanistically, it acts as a ceRNA by sponging miR-198, thereby increasing DDR1 expression."	0.7595
33364841	Cancer management and research	2020	"CircPVT1 Regulates Cell Proliferation, Apoptosis and Glycolysis in Hepatocellular Carcinoma via miR-377/TRIM23 Axis."			hsa_circ_PVT1	PVT1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circPVT1 is up-regulated in hepatocellular carcinoma tissues and cell lines, and functions as an oncogenic circRNA. It primarily localizes in the cytoplasm and promotes proliferation and glycolysis while inhibiting apoptosis by sponging miR-377 to increase TRIM23 expression, thereby enhancing tumor growth in xenograft models."	0.762
33372356	Molecular oncology	2021	CircATRNL1 activates Smad4 signaling to inhibit angiogenesis and ovarian cancer metastasis via miR-378.	hsa_circ_0020093	circATRNL1	hsa_circ_ATRNL1	ATRNL1	ovarian cancer	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR	"circATRNL1 is down-regulated in ovarian cancer and acts as a tumor suppressor. It sponges miR-378 to relieve repression of Smad4, thereby inhibiting AKT signaling, reducing proliferation/migration/invasion/angiogenesis and metastasis, and higher circATRNL1 predicts better survival."	0.7829
33372369	Journal of cellular and molecular medicine	2022	CircASPH promotes KGN cells proliferation through miR-375/MAP2K6 axis in Polycystic Ovary Syndrome.		circASPH 	hsa_circ_ASPH	ASPH	Polycystic Ovary Syndrome 	MONDO:0008487	polycystic ovary syndrome	up-regulated	RT-qPCR	"circASPH is up-regulated in PCOS granulosa cells and promotes granulosa-like (KGN) cell proliferation while inhibiting apoptosis. Mechanistically, circASPH sponges miR-375 to relieve repression of MAP2K6, forming a circASPH/miR-375/MAP2K6 ceRNA axis with potential diagnostic/therapeutic relevance in PCOS."	0.6521
33375322	Cancers	2020	Gene Expression Signatures of a Preclinical Mouse Model during Colorectal Cancer Progression under Low-Dose Metronomic Chemotherapy.			hsa_circ_ZNF609	ZNF609	colorectal cancer	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Northern Blot; RNA-seq	"circZNF609 is up-regulated during colorectal cancer progression and metastasis in the xenograft model. Functional gain- and loss-of-function experiments show it promotes tumor growth, cell proliferation, and liver metastasis; the detailed molecular mechanism is not resolved."	0.6554
33375322	Cancers	2020	Gene Expression Signatures of a Preclinical Mouse Model during Colorectal Cancer Progression under Low-Dose Metronomic Chemotherapy.			mmu_circ_Zfp609	Zfp609	colorectal cancer	MONDO:0005575	colorectal cancer	unknown	RT-qPCR; Northern Blot	"In mouse CMT93 cells and C57BL/6 syngeneic tumors, circZfp609 overexpression increases tumor growth, supporting an oncogenic role consistent with circZNF609 findings. The paper does not report an endogenous differential-expression direction for circZfp609 during disease progression."	0.4062
33376485	Gastroenterology research and practice	2020	hsa_circRNA_000166 Facilitated Cell Growth and Limited Apoptosis through Targeting miR-326/LASP1 Axis in Colorectal Cancer.		hsa_circRNA_000166			colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_000166 is upregulated in colorectal cancer tissues and cell lines and its high expression is associated with worse 5-year survival. Functionally, it promotes CRC cell growth and inhibits apoptosis by sponging miR-326, thereby regulating the downstream effector LASP1."	0.7357
33376626	Molecular therapy. Nucleic acids	2021	circPHIP promotes oral squamous cell carcinoma progression by sponging miR-142-5p and regulating PHIP and ACTN4 expression.	hsa_circ_0001615	circPHIP	hsa_circ_PHIP	PHIP	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circPHIP (hsa_circ_0001615), derived from PHIP, is up-regulated in OSCC tissues and cell lines and mainly localizes to the cytoplasm. It promotes OSCC proliferation, migration/invasion and xenograft growth by sponging miR-142-5p, thereby increasing PHIP and ACTN4 expression and activating PI3K/AKT/mTOR signaling."	0.8072
33380810	OncoTargets and therapy	2020	Knockdown of Circular RNA Hsa_circ_0000714 Can Regulate RAB17 by Sponging miR-370-3p to Reduce Paclitaxel Resistance of Ovarian Cancer Through CDK6/RB Pathway.	hsa_circ_0000714				ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"hsa_circ_0000714 is up-regulated in paclitaxel-resistant ovarian cancer cells and promotes paclitaxel resistance. It functions as a ceRNA sponge for miR-370-3p to derepress RAB17 and activate the CDK6/RB pathway, enhancing proliferation and G1/S cell-cycle progression."	0.5607
33390186	Journal of experimental & clinical cancer research : CR	2021	"CDK13 upregulation-induced formation of the positive feedback loop among circCDK13, miR-212-5p/miR-449a and E2F5 contributes to prostate carcinogenesis."	hsa_circ_0079929	circCDK13 	hsa_circ_CDK13	CDK13	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Northern Blot; Microarray	"circCDK13 is upregulated in prostate cancer and mainly localizes in the cytoplasm. It promotes PCa cell proliferation (and its depletion increases apoptosis) by sponging miR-212-5p and miR-449a to relieve repression of E2F5, forming a CDK13/circCDK13/miR-212-5p/miR-449a/E2F5 positive feedback loop that enhances tumor growth in xenografts."	0.799
33391456	Journal of Cancer	2021	Circular PVT1 regulates cell proliferation and invasion via miR-149-5p/FOXM1 axis in ovarian cancer.		circular PVT1 	hsa_circ_PVT1	PVT1	ovarian cancer 	MONDO:0008170	ovarian cancer	unknown	RT-qPCR	"In ovarian cancer cells, circPVT1 promotes cell viability/proliferation, migration and invasion and inhibits apoptosis. Mechanistically, circPVT1 acts as a ceRNA to sponge miR-149-5p, thereby increasing FOXM1 expression."	0.6376
33391469	Theranostics	2021	Integrative analysis of long extracellular RNAs reveals a detection panel of noncoding RNAs for liver cancer.	hsa_circ_0073052	circ-0073052	hsa_circ_POLK	POLK	liver cancer 	MONDO:0002691	liver cancer	up-regulated	RT-qPCR	"circ-0073052 (from POLK) is up-regulated in plasma of HCC/liver cancer patients and serves as a potential diagnostic exRNA biomarker. The study suggests its circular structure contributes to stability in plasma, and its up-regulation is independent of the linear POLK transcript."	0.5129
33391469	Theranostics	2021	Integrative analysis of long extracellular RNAs reveals a detection panel of noncoding RNAs for liver cancer.	hsa_circ_0080695	circ-0080695			liver cancer 	MONDO:0002691	liver cancer	up-regulated	RT-qPCR	"circ-0080695 is significantly up-regulated in plasma from liver cancer/HCC patients and was validated across sequencing datasets and RT-qPCR. It is a key component of the study¡¯s 3-RNA panel (with SNORD3B-1 and miR-122) for detecting liver cancer, including AFP-negative and early-stage cases."	0.4032
33391541	Theranostics	2021	Circular RNA circDLC1 inhibits MMP1-mediated liver cancer progression via interaction with HuR.	hsa_circ_0135718	circDLC1	hsa_circ_DLC1	DLC1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"circDLC1 (hsa_circ_0135718), derived from the DLC1 gene, is down-regulated in HCC tissues and its low expression predicts worse OS/RFS. Functionally, circDLC1 suppresses hepatoma cell proliferation, cell-cycle progression, migration/invasion and in vivo tumor growth/metastasis by binding HuR and weakening HuR_MMP1 mRNA interaction, which reduces MMP1 mRNA stability and expression."	0.8897
33392159	Frontiers in bioengineering and biotechnology	2020	Identification and Characterization of Circular RNA as a Novel Regulator and Biomarker in Preterm Birth.		hsa-MORC3_0001 	hsa_circ_MORC3	MORC3	Preterm birth 	MONDO:0012511	preterm premature rupture of the membranes	dysregulated	RNA-seq	"This study predicts that hsa-MORC3_0001 is dysregulated in PTB peripheral blood and may act via a ceRNA mechanism. The proposed key axis is hsa-MORC3_0001_hsa-miR-1248_CHRM2, potentially contributing to immune/inflammation processes linked to PTB."	0.348
33392159	Frontiers in bioengineering and biotechnology	2020	Identification and Characterization of Circular RNA as a Novel Regulator and Biomarker in Preterm Birth.		hsa-ANKFY1_0025	hsa_circ_ANKFY1	ANKFY1	Preterm birth 	MONDO:0012511	preterm premature rupture of the membranes	dysregulated	RNA-seq; Microarray	hsa-ANKFY1_0025 shows significant expression differences between PTB and term groups in peripheral blood and is proposed as a potential PTB biomarker. Its diagnostic performance is supported by ROC analysis (AUC reported as 0.7138) and consistency across RNA-seq and microarray.	0.5047
33392159	Frontiers in bioengineering and biotechnology	2020	Identification and Characterization of Circular RNA as a Novel Regulator and Biomarker in Preterm Birth.		hsa-FAM13B_0019	hsa_circ_FAM13B	FAM13B	Preterm birth 	MONDO:0012511	preterm premature rupture of the membranes	dysregulated	RNA-seq; Microarray	"hsa-FAM13B_0019 is reported as a stable, differentially expressed circRNA in PTB peripheral blood and is highlighted as an optimal diagnostic biomarker candidate. ROC analysis reports very high discrimination ability (AUC = 1.000)."	0.5047
33392159	Frontiers in bioengineering and biotechnology	2020	Identification and Characterization of Circular RNA as a Novel Regulator and Biomarker in Preterm Birth.		hsa-NUSAP1_0010	hsa_circ_NUSAP1	NUSAP1	Preterm birth 	MONDO:0012511	preterm premature rupture of the membranes	dysregulated	RNA-seq; Microarray	"hsa-NUSAP1_0010 is identified as a stable, differentially expressed circRNA in PTB peripheral blood and proposed as a diagnostic biomarker. Its discrimination ability is supported by ROC analysis and consistency between RNA-seq and microarray datasets."	0.5047
33392159	Frontiers in bioengineering and biotechnology	2020	Identification and Characterization of Circular RNA as a Novel Regulator and Biomarker in Preterm Birth.		hsa-LMBR1L_0001	hsa_circ_LMBR1L	LMBR1L	Preterm birth 	MONDO:0012511	preterm premature rupture of the membranes	unknown	RNA-seq	"The study¡¯s ceRNA network analysis links hsa-LMBR1L_0001 to regulation of IL-6R via has-miR-1207-3p, suggesting a potential role in PTB-related immune/inflammatory regulation. However, the article does not clearly report the direction of its differential expression in PTB."	0.1768
33392159	Frontiers in bioengineering and biotechnology	2020	Identification and Characterization of Circular RNA as a Novel Regulator and Biomarker in Preterm Birth.		hsa-RANBP9_0002	hsa_circ_RANBP9	RANBP9	Preterm birth 	MONDO:0012511	preterm premature rupture of the membranes	unknown	RNA-seq	"hsa-RANBP9_0002 is presented as a PTB biomarker candidate with very high ROC performance (AUC = 1). The ceRNA network discussion links it to regulation of hsa-miR-135a-5p, but the downstream effector genes and expression direction in PTB are not specified in the provided text."	0.348
33392180	Frontiers in cell and developmental biology	2020	Circ-ZDHHC5 Accelerates Esophageal Squamous Cell Carcinoma Progression in vitro via miR-217/ZEB1 Axis.		circ-ZDHHC5 	hsa_circ_ZDHHC5	ZDHHC5	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circ-ZDHHC5 is up-regulated in ESCC plasma, tissues and ESCC cell lines. It promotes ESCC cell proliferation, migration and invasion by functioning as a ceRNA that sponges miR-217 to increase ZEB1 expression, and is proposed as a non-invasive biomarker for ESCC detection."	0.8386
33392258	Frontiers in molecular biosciences	2020	Differential Expression Profiles and Functional Prediction of Circular RNAs in Pediatric Dilated Cardiomyopathy.	hsa_circ_0067735		hsa_circ_MED12L	MED12L	pediatric dilated cardiomyopathy 	MONDO:0016333	familial dilated cardiomyopathy	down-regulated	RT-qPCR; Microarray	"has_circ_0067735 is down-regulated in peripheral blood leukocytes from pediatric dilated cardiomyopathy patients. The study predicts a ceRNA mechanism in which has_circ_0067735 sponges hsa-miR-4262 to influence CACNA2D2, and proposes it as a potential non-invasive biomarker."	0.4773
33392258	Frontiers in molecular biosciences	2020	Differential Expression Profiles and Functional Prediction of Circular RNAs in Pediatric Dilated Cardiomyopathy.	hsa_circ_0070186		hsa_circ_ANXA3	ANXA3	pediatric dilated cardiomyopathy 	MONDO:0016333	familial dilated cardiomyopathy	up-regulated	RT-qPCR; Microarray	"has_circ_0070186 is up-regulated in peripheral blood leukocytes from pediatric dilated cardiomyopathy patients. The study predicts a ceRNA mechanism in which has_circ_0070186 binds hsa-miR-4448 and may modulate IGF1, supporting its potential as a non-invasive biomarker."	0.4773
33392258	Frontiers in molecular biosciences	2020	Differential Expression Profiles and Functional Prediction of Circular RNAs in Pediatric Dilated Cardiomyopathy.	hsa_circ_0069972		hsa_circ_CXCL5	CXCL5	pediatric dilated cardiomyopathy 	MONDO:0016333	familial dilated cardiomyopathy	down-regulated	RT-qPCR; Microarray	has_circ_0069972 is down-regulated in peripheral blood leukocytes from pediatric dilated cardiomyopathy patients and is proposed as a candidate biomarker. The paper does not specify a concrete miRNA/mRNA mechanistic axis for has_circ_0069972 beyond network-level predictions.	0.4773
33393621	Bioscience reports	2021	"Circ_0061012 contributes to IL-22-induced proliferation, migration and invasion in keratinocytes through miR-194-5p/GAB1 axis in psoriasis."	hsa_circ_0061012			SLMO2-ATP5E readthrough (SLMO2-ATP5E)	psoriasis	MONDO:0005083	psoriasis	up-regulated	RT-qPCR	"circ_0061012 is up-regulated in psoriatic lesional skin and IL-22-stimulated HaCaT keratinocytes. It promotes IL-22-induced keratinocyte proliferation, migration, and invasion by sponging miR-194-5p, thereby increasing GAB1 expression."	0.7759
33397365	Journal of biomedical science	2021	CircNOL10 suppresses breast cancer progression by sponging miR-767-5p to regulate SOCS2/JAK/STAT signaling.	hsa_circ_0000977	CircNOL10 	hsa_circ_NOL10	NOL10	breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	"In breast cancer, circNOL10 is down-regulated and functions as a tumor suppressor. It mainly localizes to the cytoplasm and sponges miR-767-5p, thereby de-repressing SOCS2 and inhibiting JAK2/STAT5 signaling, which reduces proliferation, migration, invasion, EMT, and xenograft tumor growth."	0.8912
33397440	Journal of experimental & clinical cancer research : CR	2021	Circular RNA circLMO7 acts as a microRNA-30a-3p sponge to promote gastric cancer progression via the WNT2/beta-catenin pathway.	hsa_circ_0008259	circLMO7	hsa_circ_LMO7	LMO7	Gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"circLMO7 (hsa_circ_0008259), derived from LMO7, is upregulated in gastric cancer and mainly localizes to the cytoplasm. It promotes GC proliferation, migration/invasion, EMT and in vivo tumor growth/metastasis by sponging miR-30a-3p to derepress WNT2 and activate WNT2/beta-catenin signaling, and it enhances glutaminolysis (via GLS-related metabolic changes). HNRNPL facilitates circLMO7 biogenesis by binding to flanking introns."	0.8794
33402817	"Drug design, development and therapy"	2020	Silencing of circHIPK3 Inhibits Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction by Sponging miR-185-3p.		circHIPK3	mmu_circ_HIPK3	HIPK3	cardiac hypertrophy 	MONDO:0001302	hypertensive heart disease	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in TAC- and Ang II-induced cardiac hypertrophy and mainly localizes to the cytoplasm. circHIPK3 promotes hypertrophic phenotypes by sponging miR-185-3p, thereby relieving miR-185-3p-mediated repression of CASR; circHIPK3 knockdown attenuates hypertrophy and dysfunction in vitro and in vivo."	0.8152
33403048	Journal of Cancer	2021	Upregulated expression of serum exosomal hsa_circ_0026611 is associated with lymph node metastasis and poor prognosis of esophageal squamous cell carcinoma.	hsa_circ_0026611				esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"Serum exosomal hsa_circ_0026611 is upregulated in ESCC patients with lymph node metastasis and can distinguish LNM from non-LNM cases. High serum exosomal hsa_circ_0026611 levels are associated with poorer OS and DFS, suggesting potential utility as a prognostic biomarker."	0.5416
33407443	Cancer cell international	2021	Circular RNA hsa_circ_0061395 accelerates hepatocellular carcinoma progression via regulation of the miR-877-5p/PIK3R3 axis.	hsa_circ_0061395		hsa_circ_BACH1	BACH1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"hsa_circ_0061395 (circ_0061395), derived from BACH1, is up-regulated in HCC tissues, serum, and serum-derived exosomes. It promotes HCC malignant phenotypes and tumor growth by sponging miR-877-5p to increase PIK3R3 expression (ceRNA axis)."	0.7594
33407505	Cancer cell international	2021	Circ_ZFR contributes to the paclitaxel resistance and progression of non-small cell lung cancer by upregulating KPNA4 through sponging miR-195-5p.	hsa_circ_0072083	circ_ZFR 	hsa_circ_ZFR	ZFR	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	circ_ZFR is upregulated in paclitaxel-resistant NSCLC tissues and PTX-resistant cell models. It promotes chemoresistance and malignant behaviors by sponging miR-195-5p and thereby increasing KPNA4 expression; circ_ZFR knockdown restores PTX sensitivity in vitro and in a xenograft model.	0.7228
33407514	Cancer cell international	2021	Circ-CCDC66 upregulates REXO1 expression to aggravate cervical cancer progression via restraining miR-452-5p.	hsa_circ_0001313	Circ-CCDC66 	hsa_circ_CCDC66	CCDC66	cervical cancer	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ-CCDC66 is upregulated in cervical cancer tissues and promotes proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, it functions as a miRNA sponge for miR-452-5p to increase REXO1 expression, forming a circ-CCDC66/miR-452-5p/REXO1 axis."	0.7441
33408482	OncoTargets and therapy	2020	Circ_0001175 Promotes Hepatocellular Carcinoma Cell Proliferation and Metastasis by Regulating miR-130a-5p.	hsa_circ_0001175	circ_0001175 	hsa_circ_YTHDF1	YTHDF1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0001175 is up-regulated in hepatocellular carcinoma and promotes proliferation, migration, invasion, EMT, and lung metastasis. Mechanistically, it sponges miR-130a-5p to increase SNX5 expression, forming a circ_0001175/miR-130a-5p/SNX5 ceRNA axis associated with more aggressive clinicopathologic features."	0.763
33408484	OncoTargets and therapy	2020	Circular RNA circGSE1 Promotes Cervical Cancer Progression Through miR-138-5p/Vimentin.	hsa_circ_0000722	circGSE1	hsa_circ_GSE1	GSE1	cervical cancer	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; RNA-seq	"circGSE1 (hsa_circ_0000722), derived from the GSE1 gene, is up-regulated in cervical cancer and mainly localized in the cytoplasm. It promotes cervical cancer cell migration and invasion by sponging miR-138-5p, thereby relieving repression of Vimentin. High circGSE1 correlates with aggressive clinicopathological features and poorer OS/DFS."	0.8679
33408514	Cancer management and research	2020	"CircSKA3 Modulates FOXM1 to Facilitate Cell Proliferation, Migration, and Invasion While Confine Apoptosis in Medulloblastoma via miR-383-5p."	hsa_circ_0029696	circSKA3 	hsa_circ_SKA3	SKA3	Medulloblastoma 	MONDO:0007959	medulloblastoma	up-regulated	RT-qPCR	"circSKA3 is up-regulated in medulloblastoma and mainly localized in the cytoplasm. It promotes MB cell proliferation, migration and invasion while inhibiting apoptosis by sponging miR-383-5p and thereby increasing FOXM1 expression, and its knockdown suppresses DAOY xenograft growth in vivo."	0.7635
33408523	Cancer management and research	2020	Circ_101341 Deteriorates the Progression of Clear Cell Renal Cell Carcinoma Through the miR- 411/EGLN3 Axis.	hsa_circ_0031594	circ_101341 	hsa_circ_EGLN3	EGLN3	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR	"circ_101341 is up-regulated in ccRCC tissues/cell lines and promotes malignant phenotypes (proliferation, migration, invasion, EMT) and xenograft tumor growth. Mechanistically, it acts as a cytoplasmic ceRNA that sponges miR-411 to de-repress EGLN3, and high circ_101341 is associated with worse overall survival."	0.8322
33408778	Theranostics	2021	"Estrogen-induced circRNA, circPGR, functions as a ceRNA to promote estrogen receptor-positive breast cancer cell growth by regulating cell cycle-related genes."		circPGR 	hsa_circ_PGR	PGR	estrogen receptor-positive breast cancer 	MONDO:0006512	estrogen-receptor positive breast cancer	up-regulated	RT-qPCR; RNA-seq	"circPGR (from PGR) is an estrogen-induced circRNA up-regulated in ER-positive breast tumors and enriched in ER-positive breast cancer cell lines. It localizes to the cytoplasm and functions as a ceRNA that sponges miR-301a-5p to de-repress cell cycle genes (e.g., CDK6, CDK1, CHEK2), thereby promoting cell cycle progression, proliferation, migration/invasion, and xenograft tumor growth. ASO or RNAi-mediated circPGR knockdown suppresses ER-positive breast cancer cell growth."	0.8574
33408783	Theranostics	2021	Retina as a window to cerebral dysfunction following studies with circRNA signature during neurodegeneration.		cGLIS3	mmu_circ_GLIS3	GLIS3	ischemic stroke 	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; Microarray	"cGLIS3 is up-regulated in ischemia-related neurodegeneration models and patient samples, and its silencing reduces cerebral infarct/neuronal apoptosis and alleviates retinal neurodegeneration. Mechanistically, cGLIS3 functions as a miR-203 sponge and is positively regulated by the RBP EIF4A3."	0.7827
33408787	Theranostics	2021	Novel role of circRSU1 in the progression of osteoarthritis by adjusting oxidative stress.	hsa_circ_0006577	circRSU1	hsa_circ_RSU1	RSU1	osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; ISH; RNA-seq	"circRSU1 is up-regulated in oxidative-stress/inflammation-stimulated human chondrocytes and in OA cartilage from elderly patients. It promotes ROS production, inflammatory cytokines, and ECM degradation by sponging miR-93-5p to increase MAP3K8 and activate MEK/ERK1/2 and NF-kappaB signaling; overexpression aggravates OA-like changes in a mouse OA model."	0.8537
33408787	Theranostics	2021	Novel role of circRSU1 in the progression of osteoarthritis by adjusting oxidative stress.		mmu_circRsu1	mmu_circ_Rsu1	Rsu1	osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	ISH	"Mouse circRsu1 is up-regulated in aged mouse articular cartilage and localizes to the cytoplasm. Intra-articular overexpression of circRSU1 induces OA-like cartilage damage and oxidative stress, and this effect is abolished when the miR-93-5p binding site in circRSU1 is mutated, supporting a conserved miR-93-5p-dependent mechanism."	0.527
33411690	Aging	2020	Downregulation of circFASTKD1 ameliorates myocardial infarction by promoting angiogenesis.		circFASTKD1	hsa_circ_FASTKD1	FASTKD1	myocardial infarction	MONDO:0005068	myocardial infarction	up-regulated	RT-qPCR	"circFASTKD1 inhibits endothelial angiogenesis by sponging miR-106a, thereby de-repressing LATS1/2 and suppressing Hippo/YAP signaling. Silencing circFASTKD1 enhances angiogenic behaviors under hypoxia and improves cardiac repair and function after myocardial infarction in mice."	0.7229
33413045	Technology in cancer research & treatment	2021	Identification of Circ_001569 as a Potential Biomarker in the Diagnosis and Prognosis of Pancreatic Cancer.		Circ_001569	hsa_circ_ABCC1	ABCC1	pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; Microarray	"circ_001569 is upregulated in pancreatic cancer tissues and patient plasma and is associated with aggressive clinicopathological features. High circ_001569 predicts poorer overall survival and shows moderate diagnostic performance in plasma. Functionally, circ_001569 promotes malignant phenotypes (proliferation, migration, invasion) and inhibits apoptosis in PC cell lines, while its molecular mechanism was not defined."	0.7617
33413076	"Molecular medicine (Cambridge, Mass.)"	2021	Aerobic exercise improves VCI through circRIMS2/miR-186/BDNF-mediated neuronal apoptosis.	hsa_circ_0005114	circRIMS2 	hsa_circ_RIMS2	RIMS2	Vascular cognitive impairment 	MONDO:0002039	cognitive disorder	down-regulated	RT-qPCR; Microarray	"circRIMS2 is down-regulated in VCI and functions as a ceRNA that sponges miR-186 to upregulate BDNF, thereby inhibiting neuronal apoptosis. Aerobic exercise increases circRIMS2 in the VCI mouse model, contributing to improved cognitive performance."	0.725
33413360	Cancer cell international	2021	CircNEIL3 promotes cervical cancer cell proliferation by adsorbing miR-137 and upregulating KLF12.	hsa_circ_0071474	circNEIL3	hsa_circ_NEIL3	NEIL3	cervical cancer	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"circNEIL3 (hsa_circ_0071474), derived from NEIL3, is up-regulated in cervical cancer tissues and cell lines. It mainly localizes to the cytoplasm and promotes cervical cancer cell proliferation by sponging miR-137, thereby relieving repression of KLF12 and increasing KLF12 expression; circNEIL3 knockdown suppresses xenograft growth."	0.8118
33413401	Cancer cell international	2021	CircRNA PIP5K1A promotes the progression of glioma through upregulation of the TCF12/PI3K/AKT pathway by sponging miR-515-5p.		CircPIP5K1A 	hsa_circ_PIP5K1A	PIP5K1A	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"CircPIP5K1A is up-regulated in glioma and promotes malignant behaviors (proliferation, invasion, EMT, tumor growth) while inhibiting apoptosis. Mechanistically, it sponges miR-515-5p to upregulate TCF12 and activate the PI3K/AKT pathway, and higher circPIP5K1A is associated with worse patient survival."	0.8169
33413420	Cancer cell international	2021	Expression profile of circular RNA and construction of circular RNA-Micro RNA network in salivary adenoid cystic carcinoma.		circRNA ABCA13	hsa_circ_ABCA13	ABCA13	salivary adenoid cystic carcinoma 	MONDO:0003175	salivary gland adenoid cystic carcinoma	up-regulated	RT-qPCR; RNA-seq	circRNA ABCA13 is up-regulated in SACC tissues and is proposed to promote SACC progression by inhibiting miR-138-5p. The study also predicts a downstream connection between miR-138-5p and Notch1 within a circRNA_miRNA regulatory network.	0.4032
33413420	Cancer cell international	2021	Expression profile of circular RNA and construction of circular RNA-Micro RNA network in salivary adenoid cystic carcinoma.		circRNA CASC15	hsa_circ_CASC15	CASC15	salivary adenoid cystic carcinoma 	MONDO:0003175	salivary gland adenoid cystic carcinoma	up-regulated	RT-qPCR; RNA-seq	circRNA CASC15 is identified as an up-regulated circRNA in SACC and its differential expression was validated by RT-qPCR in clinical tissues; no specific downstream mechanism was reported for this circRNA in the paper.	0.3588
33413420	Cancer cell international	2021	Expression profile of circular RNA and construction of circular RNA-Micro RNA network in salivary adenoid cystic carcinoma.		circRNA VCAN	hsa_circ_VCAN	VCAN	salivary adenoid cystic carcinoma 	MONDO:0003175	salivary gland adenoid cystic carcinoma	up-regulated	RT-qPCR; RNA-seq	circRNA VCAN is up-regulated in SACC and its differential expression was validated by RT-qPCR in clinical tissue samples; the paper does not report a specific interaction axis or functional mechanism for this circRNA.	0.3588
33413420	Cancer cell international	2021	Expression profile of circular RNA and construction of circular RNA-Micro RNA network in salivary adenoid cystic carcinoma.		circRNA LIFR	hsa_circ_LIFR	LIFR	salivary adenoid cystic carcinoma 	MONDO:0003175	salivary gland adenoid cystic carcinoma	down-regulated	RT-qPCR; RNA-seq	"circRNA LIFR is down-regulated in SACC and its expression change was validated by RT-qPCR. It was bioinformatically predicted to interact with miR-520a-5p, but qRT-PCR results for miR-520a-5p did not agree with the predicted negative relationship, and no functional role was established."	0.4032
33416105	International journal of molecular medicine	2021	Downregulation of hsa_circ_0026123 suppresses ovarian cancer cell metastasis and proliferation through the miR_124_3p/EZH2 signaling pathway.	hsa_circ_0026123		hsa_circ_TUBA1B	TUBA1B	ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"hsa_circ_0026123 is up-regulated in ovarian cancer tissues and cell lines and mainly localizes to the cytoplasm. Its knockdown suppresses proliferation, migration/metastasis and CSC differentiation and inhibits xenograft tumor growth by sponging miR-124-3p to downregulate EZH2 (miR-124-3p/EZH2 axis)."	0.6829
33416120	International journal of molecular medicine	2021	Circular RNA CSNK1G1 promotes the progression of osteoarthritis by targeting the miR_4428/FUT2 axis.		circCSNK1G1 	hsa_circ_CSNK1G1	CSNK1G1	osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circCSNK1G1 is up-regulated in osteoarthritis cartilage and promotes OA progression by enhancing inflammation, extracellular matrix degradation and chondrocyte apoptosis. Mechanistically, it acts as a miRNA sponge for miR-4428, thereby derepressing the miR-4428 target FUT2 (circCSNK1G1/miR-4428/FUT2 ceRNA axis)."	0.7052
33416147	Oncology reports	2021	circHIPK3 promotes proliferation and migration and invasion via regulation of miR_637/HDAC4 signaling in osteosarcoma cells.		circHIPK3 	hsa_circ_HIPK3	HIPK3	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in osteosarcoma tissues and cell lines and mainly localizes to the cytoplasm. It promotes osteosarcoma cell proliferation, migration and invasion by sponging miR-637 and thereby increasing HDAC4 expression; high circHIPK3 expression is associated with shorter overall survival and shows diagnostic value by ROC analysis."	0.8343
33416186	Oncology reports	2021	Hsa_circ_0016760 exacerbates the malignant development of non_small cell lung cancer by sponging miR_145_5p/FGF5.	hsa_circ_0016760				non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0016760 is upregulated in NSCLC and functions as an oncogenic circRNA that promotes proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, it sponges miR-145-5p to increase FGF5 expression, and high hsa_circ_0016760 levels are associated with poor patient survival."	0.8198
33424579	Frontiers in aging neuroscience	2020	Identification of Circular RNA hsa_Circ_0003391 in Peripheral Blood Is Potentially Associated With Alzheimer's Disease.	hsa_circ_0003391		hsa_circ_UBASH3B	UBASH3B	Alzheimer's disease 	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR; Microarray	"hsa_circ_0003391 is significantly down-regulated in peripheral blood (plasma and whole blood cells) of Alzheimer's disease patients and correlates with cognitive test scores and hippocampal volume. It shows potential diagnostic value by ROC analysis, and bioinformatic/RT-qPCR evidence suggests a potential interaction with miR-574-5p."	0.6556
33425483	Molecular therapy. Nucleic acids	2021	circRNA circARNT2 Suppressed the Sensitivity of Hepatocellular Carcinoma Cells to Cisplatin by Targeting the miR-155-5p/PDK1 Axis.	hsa_circ_0104670	circARNT2 	hsa_circ_ARNT2	ARNT2	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circARNT2 is upregulated in HCC, especially in cisplatin-resistant tissues/cells, and promotes malignant phenotypes and cisplatin resistance. Mechanistically, circARNT2 sponges miR-155-5p to increase PDK1 expression, affecting autophagy and leading to reduced cisplatin sensitivity. High circARNT2 is associated with aggressive clinicopathologic features and poorer overall survival."	0.8766
33425489	Molecular therapy. Nucleic acids	2021	CircMEG3 inhibits telomerase activity by reducing Cbf5 in human liver cancer stem cells.		CircMEG3 	hsa_circ_MEG3	MEG3	human liver cancer	MONDO:0002691	liver cancer	down-regulated	RT-qPCR	"CircMEG3 is down-regulated in human liver cancer tissues and acts as a tumor-suppressive circRNA in liver cancer stem cells. It inhibits HULC-dependent METTL3 expression, reduces m6A-related regulation of Cbf5, suppresses telomerase activity, and shortens telomere length, thereby inhibiting CSC growth and malignant differentiation."	0.7737
33425493	Molecular therapy. Nucleic acids	2021	circDCUN1D4 suppresses tumor metastasis and glycolysis in lung adenocarcinoma by stabilizing TXNIP expression.	hsa_circ_0007928	circDCUN1D4 	hsa_circ_DCUN1D4	DCUN1D4	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; ISH; Microarray	"In LUAD, circDCUN1D4 is down-regulated and functions as a tumor suppressor by inhibiting metastasis-related behaviors and glycolysis. Mechanistically, it binds HuR, promotes HuR cytoplasmic export, and stabilizes TXNIP mRNA (also via direct interaction with TXNIP 3¡äUTR), forming a circDCUN1D4/HuR/TXNIP complex. Low circDCUN1D4 expression is associated with lymph node metastasis and worse overall survival."	0.8828
33425718	Frontiers in oncology	2020	CircRNA_000864 Upregulates B-cell Translocation Gene 2 Expression and Represses Migration and Invasion in Pancreatic Cancer Cells by Binding to miR-361-3p.	hsa_circ_0000662	circRNA_000864 			pancreatic cancer	MONDO:0009831	malignant pancreatic neoplasm	down-regulated	RT-qPCR; Microarray	"circRNA_000864 is down-regulated in pancreatic cancer tissues and cell lines. Functionally, restoring circRNA_000864 suppresses proliferation, migration/invasion, promotes apoptosis and G0/G1 arrest, and inhibits xenograft tumor growth, mainly by sponging miR-361-3p to increase BTG2 expression."	0.756
33425899	Frontiers in cell and developmental biology	2020	CircHmbox1 Targeting miRNA-1247-5p Is Involved in the Regulation of Bone Metabolism by TNF-alpha in Postmenopausal Osteoporosis.	mmu_circ_0000549	circHmbox1 	mmu_circ_Hmbox1	Hmbox1	postmenopausal osteoporosis 	MONDO:0008159	postmenopausal osteoporosis	down-regulated	RT-qPCR	"In a mouse OVX osteoporosis model and TNF-alpha_stimulated osteoclastogenesis, circHmbox1 (mmu_circ_0000549) is down-regulated and suppresses osteoclast differentiation. It functions mainly as a ceRNA by sponging miR-1247-5p to increase Bcl6, and osteoclast-derived exosomal circHmbox1 modulates osteoblast differentiation; restoring circHmbox1 alleviates OVX-induced osteoporosis."	0.5634
33430866	Cancer cell international	2021	"As a biomarker for gastric cancer, circPTPN22 regulates the progression of gastric cancer through the EMT pathway."	hsa_circ_0000110	circPTPN22 	hsa_circ_PTPN22	PTPN22	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"circPTPN22 is significantly up-regulated in gastric cancer tissues, cells, and patient plasma and correlates with lymph node metastasis and worse survival. Functionally, circPTPN22 promotes proliferation, migration/invasion and tumor growth; its knockdown suppresses EMT marker changes (E-cad up, N-cad/Vimentin/Snail down). The study suggests circPTPN22 may act via a predicted ceRNA mechanism by binding multiple miRNAs (e.g., has_miR_665), supporting its diagnostic/prognostic biomarker potential."	0.7947
33431945	Scientific reports	2021	CircRNA GFRA1 promotes hepatocellular carcinoma progression by modulating the miR-498/NAP1L3 axis.		CircRNA GFRA1 	hsa_circ_GFRA1	GFRA1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circGFRA1 is up-regulated in HCC tissues and cell lines and is associated with advanced stage and poor overall survival. Functionally, circGFRA1 promotes HCC proliferation, invasion, and xenograft tumor growth by sponging miR-498 to increase NAP1L3 expression."	0.7891
33433033	Movement disorders : official journal of the Movement Disorder Society	2021	Differentially Expressed Circular RNAs in Peripheral Blood Mononuclear Cells of Patients with Parkinson's Disease.	hsa_circ_0001566		hsa_circ_MAPK9	MAPK9	Parkinson's disease 	MONDO:0005180	Parkinson disease	down-regulated	RT-qPCR	"MAPK9_circ_0001566 is down-regulated in PBMCs from idiopathic PD patients. The study predicts it participates in PD-related ceRNA/RBP networks by sequestering miRNAs and RBPs, and it contributes to a multi-circRNA diagnostic panel for PD."	0.459
33433033	Movement disorders : official journal of the Movement Disorder Society	2021	Differentially Expressed Circular RNAs in Peripheral Blood Mononuclear Cells of Patients with Parkinson's Disease.	hsa_circ_0006916		hsa_circ_HOMER1	HOMER1	Parkinson's disease 	MONDO:0005180	Parkinson disease	down-regulated	RT-qPCR	HOMER1_circ_0006916 is down-regulated in PBMCs from idiopathic PD patients. The study suggests it may modulate PD-relevant regulatory networks via predicted binding to miRNAs and RBPs.	0.348
33433033	Movement disorders : official journal of the Movement Disorder Society	2021	Differentially Expressed Circular RNAs in Peripheral Blood Mononuclear Cells of Patients with Parkinson's Disease.	hsa_circ_0000497		hsa_circ_SLAIN1	SLAIN1	Parkinson's disease 	MONDO:0005180	Parkinson disease	down-regulated	RT-qPCR	SLAIN1_circ_0000497 is down-regulated in PBMCs of idiopathic PD patients and is part of a 4-circRNA diagnostic classifier. It is predicted to act through miRNA/RBP sequestration within PD-related regulatory networks.	0.459
33433033	Movement disorders : official journal of the Movement Disorder Society	2021	Differentially Expressed Circular RNAs in Peripheral Blood Mononuclear Cells of Patients with Parkinson's Disease.	hsa_circ_0001187		hsa_circ_DOP1B	DOP1B	Parkinson's disease 	MONDO:0005180	Parkinson disease	down-regulated	RT-qPCR	DOP1B_circ_0001187 is down-regulated in PBMCs from idiopathic PD patients. The work suggests it may influence PD-related regulation by interacting with miRNAs and RBPs based on in-silico/CLIP-seq-derived interaction networks.	0.348
33433033	Movement disorders : official journal of the Movement Disorder Society	2021	Differentially Expressed Circular RNAs in Peripheral Blood Mononuclear Cells of Patients with Parkinson's Disease.	hsa_circ_0004368		hsa_circ_REPS1	REPS1	Parkinson's disease 	MONDO:0005180	Parkinson disease	down-regulated	RT-qPCR	"RESP1_circ_0004368 is down-regulated in PBMCs from idiopathic PD patients. The study proposes it may affect PD biology via predicted sequestration of miRNAs and RBPs, implying increased activity of those targets when the circRNA is reduced."	0.348
33433033	Movement disorders : official journal of the Movement Disorder Society	2021	Differentially Expressed Circular RNAs in Peripheral Blood Mononuclear Cells of Patients with Parkinson's Disease.	hsa_circ_0003848		hsa_circ_PSEN1	PSEN1	Parkinson's disease 	MONDO:0005180	Parkinson disease	down-regulated	RT-qPCR	PSEN1_circ_0003848 is down-regulated in PBMCs from idiopathic PD patients and is part of a 4-circRNA panel with AUC 0.84 for distinguishing PD from controls. It is predicted to participate in miRNA/RBP-associated regulatory networks in PD.	0.459
33433832	Molecular and cellular biochemistry	2021	The circular RNA circSlc7a11 promotes bone cancer pain pathogenesis in rats by modulating LLC-WRC 256 cell proliferation and apoptosis.		circSlc7a11	rno_circ_Slc7a11	Slc7a11	bone cancer pain 	MONDO:0002129	bone cancer	up-regulated	RT-qPCR	"circSlc7a11 is up-regulated in the spinal cords of rat bone cancer pain (BCP) models. Functional assays show it promotes proliferation and inhibits apoptosis of LLC-WRC 256 and UMR-106 cells. Mechanistically, it is linked to broad transcriptomic changes and a predicted circRNA_miRNA_mRNA network involving genes such as Pax8, Isg15 and Cxcl10, implicating apoptotic processes and chemokine-related signaling in BCP pathogenesis."	0.657
33435987	Journal of orthopaedic surgery and research	2021	Circular RNA circ_0081001 knockdown enhances methotrexate sensitivity in osteosarcoma cells by regulating miR-494-3p/TGM2 axis.	hsa_circ_0081001		hsa_circ_CYP51A1	CYP51A1	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ_0081001 is up-regulated in osteosarcoma, especially in MTX-resistant tissues/cells, and high expression predicts poor survival. It promotes MTX resistance and malignant phenotypes by acting as a ceRNA sponge for miR-494-3p, thereby increasing TGM2 expression; circ_0081001 knockdown enhances MTX sensitivity in vitro and in xenograft tumors."	0.8066
33436040	Arthritis research & therapy	2021	Hsa_circ_0123190 acts as a competitive endogenous RNA to regulate APLNR expression by sponging hsa-miR-483-3p in lupus nephritis.	hsa_circ_0123190				lupus nephritis 	MONDO:0005556	lupus nephritis	down-regulated	RT-qPCR; RNA-seq	"In lupus nephritis, hsa_circ_0123190 is down-regulated in renal tissue and peripheral blood. It functions as a ceRNA by sponging hsa-miR-483-3p to regulate APLNR, linking it to renal fibrosis-related changes, and it shows diagnostic potential in blood (AUC 0.900)."	0.6709
33436041	Journal of experimental & clinical cancer research : CR	2021	Hsa_circ_0005273 facilitates breast cancer tumorigenesis by regulating YAP1-hippo signaling pathway.	hsa_circ_0005273		hsa_circ_PTK2	PTK2	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005273 is up-regulated in breast cancer tissues and cell lines and promotes tumorigenesis (proliferation, migration, cell-cycle progression, and xenograft growth). Mechanistically, it acts as a cytoplasmic miR-200a-3p sponge to increase YAP1 and thereby inactivate Hippo signaling."	0.8771
33436560	Nature communications	2021	circNDUFB2 inhibits non-small cell lung cancer progression via destabilizing IGF2BPs and activating anti-tumor immunity.	hsa_circ_0007518	circNDUFB2	hsa_circ_NDUFB2	NDUFB2	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"circNDUFB2 (hsa_circ_0007518), derived from NDUFB2, is down-regulated in NSCLC and acts as a tumor suppressor. It scaffolds TRIM25 with IGF2BP1/2/3 to promote IGF2BP ubiquitination/proteasomal degradation in an m6A-enhanced manner, and it also activates RIG-I_MAVS innate immune signaling to increase cytokines/chemokines and recruit immune cells into the tumor microenvironment, thereby inhibiting NSCLC growth and metastasis."	0.8641
33436852	Scientific reports	2021	CircRNA_103765 acts as a proinflammatory factor via sponging miR-30 family in Crohn's disease.		hsa_circRNA_103765 	hsa_circ_KLHL2	KLHL2	inflammatory bowel disease 	MONDO:0005265	inflammatory bowel disease	up-regulated	RT-qPCR; Microarray	"circRNA_103765 is up-regulated in PBMCs from active IBD (CD/UC) patients and is induced by TNF-alpha. It promotes IEC apoptosis (and affects proliferation) by acting as a ceRNA that sponges miR-30a-5p/miR-30e-5p to increase DLL4 and downstream Notch signaling (NICD, Hes1)."	0.7492
33437212	International journal of medical sciences	2021	circRNA expression pattern and ceRNA network in the pathogenesis of aseptic loosening after total hip arthroplasty.	hsa_circ_0007482				aseptic loosening after total hip arthroplasty 	MONDO:0005380	osteonecrosis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0007482 is significantly up-regulated in aseptic loosening synovial tissues after THA and was included as a key circRNA in the constructed circRNA-miRNA-mRNA (ceRNA) network. KEGG enrichment of its predicted target mRNAs implicated pathways including cGMP-PKG signaling and DNA repair-related processes, suggesting potential involvement in aseptic loosening pathogenesis via ceRNA regulation."	0.4032
33437212	International journal of medical sciences	2021	circRNA expression pattern and ceRNA network in the pathogenesis of aseptic loosening after total hip arthroplasty.	hsa_circ_0005232				aseptic loosening after total hip arthroplasty 	MONDO:0005380	osteonecrosis	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0005232 is significantly down-regulated in aseptic loosening synovial tissues after THA and was incorporated into a predicted circRNA-miRNA-mRNA (ceRNA) network. Enrichment of its predicted downstream target mRNAs suggested involvement of inflammatory/immune-related pathways such as Toll-like receptor and chemokine signaling in aseptic loosening.	0.4032
33437212	International journal of medical sciences	2021	circRNA expression pattern and ceRNA network in the pathogenesis of aseptic loosening after total hip arthroplasty.	hsa_circ_0000994				aseptic loosening after total hip arthroplasty 	MONDO:0005380	osteonecrosis	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000994 is significantly down-regulated in aseptic loosening synovial tissues after THA and was used to build a predicted circRNA-miRNA-mRNA (ceRNA) network. Its predicted downstream target genes were enriched in pathways including Toll-like receptor signaling and chemokine signaling, suggesting possible roles in inflammation-related mechanisms of aseptic loosening."	0.4032
33437212	International journal of medical sciences	2021	circRNA expression pattern and ceRNA network in the pathogenesis of aseptic loosening after total hip arthroplasty.	hsa_circ_0000690				aseptic loosening after total hip arthroplasty 	MONDO:0005380	osteonecrosis	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000690 is significantly down-regulated in aseptic loosening synovial tissues after THA and was part of the predicted circRNA-miRNA-mRNA (ceRNA) network. Predicted downstream target mRNAs of the downregulated circRNA group were enriched in Toll-like receptor and chemokine signaling pathways, implicating immune/inflammatory processes in aseptic loosening."	0.4032
33437212	International journal of medical sciences	2021	circRNA expression pattern and ceRNA network in the pathogenesis of aseptic loosening after total hip arthroplasty.	hsa_circ_0058092				aseptic loosening after total hip arthroplasty 	MONDO:0005380	osteonecrosis	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0058092 is significantly down-regulated in aseptic loosening synovial tissues after THA and was included in the predicted ceRNA network. Pathway enrichment of predicted target mRNAs for the downregulated circRNA group highlighted Toll-like receptor and chemokine signaling pathways, linking this circRNA to immune/inflammatory components of aseptic loosening."	0.4032
33437212	International journal of medical sciences	2021	circRNA expression pattern and ceRNA network in the pathogenesis of aseptic loosening after total hip arthroplasty.	hsa_circ_0004496				aseptic loosening after total hip arthroplasty 	MONDO:0005380	osteonecrosis	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0004496 is significantly down-regulated in aseptic loosening synovial tissues after THA and was used for subsequent ceRNA network construction. Enrichment analyses of predicted target mRNAs for the downregulated circRNA set emphasized Toll-like receptor and chemokine signaling pathways, suggesting a potential link to inflammatory mechanisms in aseptic loosening."	0.4032
33437631	Journal of orthopaedic translation	2021	Identification of circ-FAM169A sponges miR-583 involved in the regulation of intervertebral disc degeneration.	hsa_circ_0007158	circ-FAM169A 	hsa_circ_FAM169A	FAM169A	intervertebral disc degeneration 	MONDO:0011385	intervertebral disk degenerative disorder	up-regulated	RT-qPCR; Microarray	"circ-FAM169A is up-regulated in degenerative human NP tissues in IDD. It localizes to the cytoplasm and acts as a ceRNA that directly sponges miR-583, thereby influencing the miR-583 target Sox9 and potentially modulating ECM metabolism and apoptosis in NPCs."	0.659
33439739	Cell transplantation	2021	hsa_circ_0023409 Accelerates Gastric Cancer Cell Growth and Metastasis Through Regulating the IRS4/PI3K/AKT Pathway.	hsa_circ_0023409		hsa_circ_RNF121	RNF121	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; ISH	"In gastric cancer, hsa_circ_0023409 is up-regulated and mainly localized in the cytoplasm. It promotes proliferation, migration/invasion and inhibits apoptosis by sponging miR-542-3p to upregulate IRS4 and activate the PI3K/AKT pathway, and its high expression is associated with worse survival."	0.8192
33439746	Cell transplantation	2021	LncRNA CCDC26 Interacts with CELF2 Protein to Enhance Myeloid Leukemia Cell Proliferation and Invasion via the circRNA_ANKIB1/miR-195-5p/PRR11 Axis.		circRNA_ANKIB1 	hsa_circ_ANKIB1	ANKIB1	myeloid leukemia 	MONDO:0004643	myeloid leukemia	unknown	RT-qPCR	"In myeloid leukemia cell lines, circRNA_ANKIB1 is regulated by the CCDC26_CELF2 interaction and functions as a ceRNA that sponges miR-195-5p, increasing PRR11 expression. This axis promotes leukemia cell proliferation and invasion and suppresses apoptosis, associated with activation of PI3K/AKT and NF-kappaB signaling downstream of PRR11."	0.657
33442268	OncoTargets and therapy	2021	Circ_0006404 Accelerates Prostate Cancer Progression Through Regulating miR-1299/CFL2 Signaling.	hsa_circ_0006404	circ_0006404 	hsa_circ_FOXO3	FOXO3	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circ_0006404 (circFOXO3) is up-regulated in prostate cancer tissues and cell lines, promotes malignant phenotypes (proliferation, migration/invasion) and inhibits apoptosis. Mechanistically, it sponges miR-1299 to increase CFL2 expression, promoting tumor growth in a DU145 xenograft model."	0.7979
33442269	OncoTargets and therapy	2021	Circ_0007444 Inhibits the Progression of Ovarian Cancer via Mediating the miR-570-3p/PTEN Axis.	hsa_circ_0007444	circ_0007444			Ovarian cancer 	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR	"circ_0007444 is down-regulated in ovarian cancer and functions as a tumor suppressor. It sponges miR-570-3p to increase PTEN, thereby inhibiting proliferation/migration/invasion and promoting apoptosis, and it suppresses xenograft tumor growth in vivo."	0.8154
33442296	Cancer management and research	2021	Circular RNA circ_0020123 Promotes Non-Small Cell Lung Cancer Progression Through miR-384/TRIM44 Axis.	hsa_circ_0020123	circ_0020123		PDZD8	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0020123 is up-regulated in NSCLC tissues and cell lines and promotes malignant phenotypes (viability, migration, invasion, EMT) while inhibiting apoptosis. Mechanistically, it sponges miR-384 to increase TRIM44 expression (circ_0020123/miR-384/TRIM44 axis), and its knockdown suppresses xenograft tumor growth; high circ_0020123 is associated with worse overall survival."	0.8347
33445426	Genes	2021	Identification of Circular RNAs in Hypothalamus of Gilts during the Onset of Puberty.		circ 11:4104218-4118265	ssc_circ_CDK8	CDK8	pubertal transition 	MONDO:0024990	swine disease	down-regulated	RNA-seq	This circRNA is differentially down-regulated during pubertal transition in gilt hypothalamus. It is proposed to act as a miRNA sponge (ssc-miR-34a) to modulate the expression of the puberty-associated gene FSTL4.	0.1768
33445426	Genes	2021	Identification of Circular RNAs in Hypothalamus of Gilts during the Onset of Puberty.		circ 3:103726106-103773127	ssc_circ_CRIM1	CRIM1	pubertal transition 	MONDO:0024990	swine disease	dysregulated	RNA-seq	This circRNA shows stage-dependent dysregulation during pubertal transition in gilt hypothalamus. It is implicated in a circRNA_miRNA_gene regulatory relationship with ssc-miR-4331-3p and the puberty-related gene SULT1E1.	0.1768
33446214	Cancer cell international	2021	Knockdown of circRNA_0007534 suppresses the tumorigenesis of cervical cancer via miR-206/GREM1 axis.	hsa_circ_0007534	circRNA_0007534 	hsa_circ_DDX42	DDX42	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"Circ_0007534 is up-regulated in cervical cancer tissues and cell lines and functions as an oncogenic circRNA. It sponges miR-206 to increase GREM1 expression, thereby promoting proliferation/viability and invasion and inhibiting apoptosis, and its knockdown suppresses xenograft tumor growth via the miR-206/GREM1 axis."	0.6973
33446260	Genome biology	2021	A novel protein encoded by circular SMO RNA is essential for Hedgehog signaling activation and glioblastoma tumorigenicity.	hsa_circ_0001742	circ-SMO	hsa_circ_SMO	SMO	glioblastoma 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; Northern Blot; ISH; RNA-seq	"circ-SMO (hsa_circ_0001742), derived from the SMO gene, is up-regulated in glioblastoma/CSCs and mainly localized in the cytoplasm. It encodes the protein SMO-193a.a., which binds SMO, enhances SMO cholesterol modification, and promotes Shh-induced Hedgehog signaling activation, thereby supporting CSC self-renewal/proliferation and in vivo tumorigenicity. High circ-SMO expression is associated with worse overall survival in a GBM patient cohort."	0.8979
33447417	Journal of thoracic disease	2020	Reduced expression of circRNA novel_circ_0005280 and its clinical value in the diagnosis of non-small cell lung cancer.	hsa_circ_0005280	novel_circ_0005280	hsa_circ_SCN7A	SCN7A	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	"novel_circ_0005280 (host gene SCN7A) is down-regulated in NSCLC tumor tissues versus adjacent tissues. It shows strong diagnostic performance (ROC AUC 0.944) and lower expression is associated with worse overall survival, suggesting utility as a diagnostic and prognostic biomarker."	0.636
33453148	Cancer science	2021	CircPVT1 promotes progression in clear cell renal cell carcinoma by sponging miR-145-5p and regulating TBX15 expression.	hsa_circ_0001821	circPVT1	hsa_circ_PVT1	PVT1	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR; Microarray	"circPVT1 (hsa_circ_0001821), derived from PVT1, is up-regulated in ccRCC tissues and serum and is associated with advanced stage. Functionally, it promotes ccRCC proliferation, migration/invasion, and in vivo tumor growth/metastasis. Mechanistically, it acts as a ceRNA sponging miR-145-5p to upregulate TBX15."	0.8802
33458917	Cell proliferation	2021	Circ_SMAD4 promotes gastric carcinogenesis by activating wnt/beta-catenin pathway.	hsa_circ_0047718	circ_SMAD4	hsa_circ_SMAD4	SMAD4	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circ_SMAD4 (hsa_circ_0047718), derived from SMAD4, is up-regulated in gastric cancer and its high expression is associated with worse survival. It promotes GC proliferation and tumorigenesis by activating CTNNB1-dependent Wnt/beta-catenin signaling via recruiting TCF4 to enhance CTNNB1 transcription and sponging miR-1276 to relieve post-transcriptional repression of CTNNB1."	0.891
33462208	Cell death & disease	2021	Hsa_circ_0007456 regulates the natural killer cell-mediated cytotoxicity toward hepatocellular carcinoma via the miR-6852-3p/ICAM-1 axis.	hsa_circ_0007456	circ_0007456			hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"In HCC, hsa_circ_0007456 is down-regulated and increases tumor-cell susceptibility to NK cell-mediated killing. Mechanistically, it sponges miR-6852-3p to upregulate ICAM-1, and the miR-6852-3p/ICAM-1 axis is required for the NK-cytotoxicity phenotype."	0.6324
33467444	Genes	2021	Systematic Identification and Analysis of Circular RNAs of Japanese Flounder (Paralichthys olivaceus) in Response to Vibrio anguillarum Infection.		circ_005398	pol_circ_SDC4	SDC4	Vibrio anguillarum infection 	MONDO:0005583	non-human animal disease	dysregulated	RNA-seq	"circ_005398 is an immune-related differentially expressed circRNA in flounder spleen after V. anguillarum infection and is implicated in immune defense by regulating its parental gene SDC4, associated with CAMs and ECM_receptor interaction pathways."	0.31
33467444	Genes	2021	Systematic Identification and Analysis of Circular RNAs of Japanese Flounder (Paralichthys olivaceus) in Response to Vibrio anguillarum Infection.		circ_000857	pol_circ_IL-4Ralpha	IL-4Ralpha	Vibrio anguillarum infection 	MONDO:0005583	non-human animal disease	dysregulated	RNA-seq	"circ_000857 is an immune-related differentially expressed circRNA in flounder spleen after V. anguillarum infection. It is predicted to act as a miRNA sponge (including miR-29-x and miR-146-x) and is linked to cytokine_cytokine receptor interaction through its parental gene IL-4Ralpha, suggesting a role in pathogen-induced immune responses."	0.31
33467444	Genes	2021	Systematic Identification and Analysis of Circular RNAs of Japanese Flounder (Paralichthys olivaceus) in Response to Vibrio anguillarum Infection.		circ_000859	pol_circ_IL-4Ralpha	IL-4Ralpha	Vibrio anguillarum infection 	MONDO:0005583	non-human animal disease	dysregulated	RNA-seq	"circ_000859 is an immune-related differentially expressed circRNA in flounder spleen after V. anguillarum infection. It is predicted to sponge multiple DETmiRs (including miR-194-y and miR-322-y) and is linked to cytokine_cytokine receptor interaction through its parental gene IL-4Ralpha, suggesting involvement in pathogen-induced immune responses."	0.31
33467444	Genes	2021	Systematic Identification and Analysis of Circular RNAs of Japanese Flounder (Paralichthys olivaceus) in Response to Vibrio anguillarum Infection.		circ_004625	pol_circ_SH3GLB2	SH3GLB2	Vibrio anguillarum infection 	MONDO:0005583	non-human animal disease	dysregulated	RNA-seq	circ_004625 is an immune-related differentially expressed circRNA in flounder spleen after V. anguillarum infection. It is implicated in immune defense by regulating its parental gene SH3GLB2 and thereby engaging the endocytosis-related response during infection.	0.31
33467444	Genes	2021	Systematic Identification and Analysis of Circular RNAs of Japanese Flounder (Paralichthys olivaceus) in Response to Vibrio anguillarum Infection.		circ_000528			Vibrio anguillarum infection 	MONDO:0005583	non-human animal disease	dysregulated	RNA-seq	"circ_000528 is implicated in the flounder response to V. anguillarum infection as part of an immune-related circRNA_miRNA network. It is predicted to target (sponge) miR-29-x, suggesting a ceRNA-like role in pathogen-induced immune regulation."	0.31
33467964	Bioengineered	2021	"Circular RNA circ_0001287 inhibits the proliferation, metastasis, and radiosensitivity of non-small cell lung cancer cells by sponging microRNA miR-21 and up-regulating phosphatase and tensin homolog expression."	hsa_circ_0001287	circ_0001287	hsa_circ_TCAIM	TCAIM	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"circ_0001287 is down-regulated in NSCLC tissues and cell lines and functions as a tumor suppressor. It sponges miR-21 to relieve repression of PTEN, thereby inhibiting proliferation/migration/invasion and reducing radioresistance (enhancing radiosensitivity) in NSCLC cells."	0.6825
33468140	Molecular cancer	2021	Circular RNA circSDHC serves as a sponge for miR-127-3p to promote the proliferation and metastasis of renal cell carcinoma via the CDKN3/E2F1 axis.	hsa_circ_0015004	circSDHC 	hsa_circ_SDHC	SDHC	renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR; Microarray	"circSDHC is up-regulated in RCC/ccRCC and mainly localizes to the cytoplasm. It promotes proliferation and metastasis by sponging miR-127-3p to derepress CDKN3 and activate the E2F1 pathway, and high circSDHC predicts poor survival."	0.8865
33468219	Diabetology & metabolic syndrome	2021	Knockdown of circ-FANCA alleviates LPS-induced HK2 cell injury via targeting miR-93-5p/OXSR1 axis in septic acute kidney injury.		Circ-FANCA 	hsa_circ_FANCA	FANCA	septic acute kidney injury 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR	"circ-FANCA is up-regulated in septic AKI patient serum and in LPS-treated HK2 cells. Silencing circ-FANCA alleviates LPS-induced HK2 injury by promoting proliferation and reducing apoptosis, inflammation, and oxidative stress via a ceRNA mechanism in which circ-FANCA sponges miR-93-5p to upregulate OXSR1; circ-FANCA is also present in exosomes from LPS-treated HK2 cells."	0.7795
33469368	Cancer management and research	2021	Up-Regulation of circEIF6 Contributes to Pancreatic Cancer Development Through Targeting miR-557/SLC7A11/PI3K/AKT Signaling.	hsa_circ_0060055	circEIF6	hsa_circ_EIF6	EIF6	pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"circEIF6 (hsa_circ_0060055) is up-regulated in pancreatic cancer and promotes malignant phenotypes and xenograft growth. Mechanistically, it sponges miR-557 to relieve repression of SLC7A11 and thereby enhances PI3K/AKT pathway activation."	0.7657
33469375	Cancer management and research	2021	Circ_LDLR Knockdown Suppresses Progression of Hepatocellular Carcinoma via Modulating miR-7/RNF38 Axis.	hsa_circ_0003892	circ_LDLR 	hsa_circ_LDLR	LDLR	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_LDLR is up-regulated in hepatocellular carcinoma tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation, migration/invasion and EMT while inhibiting apoptosis, at least partly by sponging miR-7 to derepress RNF38 (circ_LDLR/miR-7/RNF38 axis). circ_LDLR depletion suppresses xenograft tumor growth in vivo."	0.7419
33469676	Oncology reports	2021	Hsa_circ_0008537 facilitates liver carcinogenesis by upregulating MCL1 and Snail1 expression via miR_153_3p.	hsa_circ_0008537	circ_0008537 	hsa_circ_GLI3	GLI3	liver cancer	MONDO:0002691	liver cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0008537 (circ_0008537), derived from the host gene GLI3, is up-regulated in liver cancer tissues and cell lines and is associated with worse overall survival. Functionally, it promotes liver cancer cell proliferation, migration, and invasion. Mechanistically, it acts as a ceRNA by sponging miR-153-3p, thereby indirectly increasing MCL1 and Snail1 expression."	0.8568
33472586	BMC molecular and cell biology	2021	circRNA_0005529 facilitates growth and metastasis of gastric cancer via regulating miR-527/Sp1 axis.	hsa_circ_0005529	circRNA_0005529 	hsa_circ_VPS33B	VPS33B	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circ_0005529 (from VPS33B) is upregulated in gastric cancer and mainly localized in the cytoplasm. It promotes GC cell proliferation, migration/invasion and in vivo tumor growth/metastasis by sponging miR-527 and relieving repression of Sp1, thereby facilitating EMT-related phenotypes."	0.8457
33479208	Cell death & disease	2021	Circular RNA circRUNX1 promotes papillary thyroid cancer progression and metastasis by sponging MiR-296-3p and regulating DDHD2 expression.	hsa_circ_0002360	circRUNX1	hsa_circ_RUNX1	RUNX1	papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"circRUNX1 is up-regulated in papillary thyroid cancer and promotes proliferation, migration and invasion in vitro and tumor growth in vivo. Mechanistically, circRUNX1 mainly localizes in the cytoplasm and acts as a ceRNA by sponging miR-296-3p, thereby relieving repression of DDHD2 and driving PTC progression."	0.8265
33481351	Cancer medicine	2021	Circ_0008305-mediated miR-660/BAG5 axis contributes to hepatocellular carcinoma tumorigenesis.	hsa_circ_0008305	circ_0008305			hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0008305 is up-regulated in HCC tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion, tumor growth) while suppressing apoptosis. Mechanistically, it functions as a ceRNA sponging miR-660/miR-660-5p to upregulate BAG5, forming a circ_0008305_miR-660_BAG5 axis driving HCC progression."	0.6917
33482819	Cancer cell international	2021	Three novel circRNAs upregulated in tissue and plasma from hepatocellular carcinoma patients and their regulatory network.	hsa_circ_0009910		hsa_circ_MFN2	MFN2	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0009910 is up-regulated in HCC tissue and plasma and was experimentally validated as a circular, RNase R_resistant transcript that can be excreted into hepatoma-cell culture medium. It is proposed to act in a circRNA_miRNA_mRNA (ceRNA) network by interacting with hsa-miR-455-5p and hsa-miR-615-3p to modulate cell-cycle/DNA-replication hub genes (e.g., MCM family, CCNB1, CDC20, CDC7, DLGAP5)."	0.6193
33482819	Cancer cell international	2021	Three novel circRNAs upregulated in tissue and plasma from hepatocellular carcinoma patients and their regulatory network.	hsa_circ_0049783		hsa_circ_CLEC17A	CLEC17A	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	Microarray	"hsa_circ_0049783 is up-regulated in HCC tissue and plasma based on circRNA microarray meta-analysis. The study proposes a ceRNA module hsa_circ_0049783/hsa-miR-18a-3p/ZWINT within a circRNA_miRNA_mRNA regulatory network, but without experimental circularity/RT-qPCR validation for this circRNA."	0.348
33482819	Cancer cell international	2021	Three novel circRNAs upregulated in tissue and plasma from hepatocellular carcinoma patients and their regulatory network.	hsa_circ_0089172		hsa_circ_NUP214	NUP214	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0089172 is up-regulated in HCC tissue and plasma and was experimentally validated as a circular, RNase R_resistant transcript that can be excreted into hepatoma-cell culture medium. It is proposed to act as a ceRNA by interacting with hsa-miR-4524a-3p to influence cell-cycle/DNA-replication hub genes (e.g., CDC7, CCNB1, CENPU, ASPM, ECT2, NDC80)."	0.6193
33483472	Cell death discovery	2021	Circ-NOLC1 promotes epithelial ovarian cancer tumorigenesis and progression by binding ESRP1 and modulating CDK1 and RhoA expression.		Circ-NOLC1	hsa_circ_NOLC1	NOLC1	epithelial ovarian cancer 	MONDO:0005140	ovarian carcinoma	up-regulated	RT-qPCR	"circ-NOLC1 is up-regulated in epithelial ovarian cancer and is associated with more advanced FIGO stage, poorer differentiation, and CA125 positivity. Functionally, it promotes proliferation, migration and invasion and inhibits apoptosis in vitro, and enhances tumor growth in a cell line-derived xenograft model. Mechanistically, it binds the RBP ESRP1 (validated by RIP) and increases ESRP1, CDK1 and RhoA expression, supporting an ESRP1-mediated regulation of CDK1/RhoA rather than a direct miRNA-sponge effect for the tested miRNAs."	0.6833
33484110	Journal of cellular and molecular medicine	2021	Analysis of changes in circular RNA expression and construction of ceRNA networks in human dilated cardiomyopathy.		Chr7:8257935_8275635_			dilated cardiomyopathy 	MONDO:0005021	dilated cardiomyopathy	up-regulated	RT-qPCR; RNA-seq	"This circRNA is significantly up-regulated in human DCM heart tissue and was validated by qRT-PCR. It is included as part of the study¡¯s predicted ceRNA (circRNA-miRNA-mRNA) network analysis framework, but no specific downstream miRNA/mRNA axis was reported for this individual circRNA in the provided text."	0.5135
33484110	Journal of cellular and molecular medicine	2021	Analysis of changes in circular RNA expression and construction of ceRNA networks in human dilated cardiomyopathy.		chr4:187627717_187630999_			dilated cardiomyopathy 	MONDO:0005021	dilated cardiomyopathy	up-regulated	RT-qPCR; RNA-seq	"This circRNA is significantly up-regulated in human DCM heart tissue and was validated by qRT-PCR. It was included in the study¡¯s overall ceRNA-network construction, but no specific miRNA/mRNA targets were detailed for it in the provided text."	0.5135
33484110	Journal of cellular and molecular medicine	2021	Analysis of changes in circular RNA expression and construction of ceRNA networks in human dilated cardiomyopathy.		chr1:219352489_219385095+			dilated cardiomyopathy 	MONDO:0005021	dilated cardiomyopathy	up-regulated	RT-qPCR; RNA-seq	"This circRNA is significantly up-regulated in human DCM heart tissue and was validated by qRT-PCR. It was used in the study¡¯s ceRNA-network prediction analyses, but no specific interacting miRNAs/mRNAs were reported for this circRNA in the provided text."	0.5135
33484110	Journal of cellular and molecular medicine	2021	Analysis of changes in circular RNA expression and construction of ceRNA networks in human dilated cardiomyopathy.		Chr5:158204421_158267118_			dilated cardiomyopathy 	MONDO:0005021	dilated cardiomyopathy	down-regulated	RT-qPCR; RNA-seq	"This circRNA is significantly down-regulated in human DCM heart tissue and was validated by qRT-PCR. It was incorporated into the predicted circRNA-miRNA-mRNA ceRNA network analysis, but no specific miRNA/mRNA partners were reported for it in the provided text."	0.5135
33484110	Journal of cellular and molecular medicine	2021	Analysis of changes in circular RNA expression and construction of ceRNA networks in human dilated cardiomyopathy.		chr1:247200894_247202839_			dilated cardiomyopathy 	MONDO:0005021	dilated cardiomyopathy	down-regulated	RT-qPCR; RNA-seq	"This circRNA is significantly down-regulated in human DCM heart tissue and was validated by qRT-PCR. It served as an input to the study¡¯s predicted ceRNA networks, with no individual miRNA/mRNA axis specified in the provided text."	0.5135
33484110	Journal of cellular and molecular medicine	2021	Analysis of changes in circular RNA expression and construction of ceRNA networks in human dilated cardiomyopathy.		chr13:35615070_35672542+			dilated cardiomyopathy 	MONDO:0005021	dilated cardiomyopathy	down-regulated	RT-qPCR; RNA-seq	"This circRNA is significantly down-regulated in human DCM heart tissue and was validated by qRT-PCR. It was included in the study¡¯s predicted ceRNA networks, but no specific downstream miRNA/mRNA interactions were reported for it in the provided text."	0.5135
33484498	Journal of cellular and molecular medicine	2021	CircCAMSAP1 promotes hepatocellular carcinoma progression through miR-1294/GRAMD1A pathway.		circCAMSAP1	hsa_circ_CAMSAP1	CAMSAP1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circCAMSAP1 is up-regulated in hepatocellular carcinoma and promotes malignant phenotypes (proliferation, migration, invasion) and xenograft growth. Mechanistically, it mainly localizes to the cytoplasm and acts as a ceRNA by sponging miR-1294, thereby increasing GRAMD1A expression."	0.7564
33489803	Translational lung cancer research	2020	Hsa_circ_0006571 promotes spinal metastasis through sponging microRNA-138 to regulate sirtuin 1 expression in lung adenocarcinoma.	hsa_circ_0006571		hsa_circ_SATB2	SATB2	spinal metastasis 	MONDO:0044912	metastatic malignant neoplasm in the spinal cord	up-regulated	RT-qPCR; Microarray	"hsa_circ_0006571 (from SATB2) is up-regulated in spinal metastasis tissues of lung adenocarcinoma and mainly localizes to the cytoplasm. It promotes proliferation, migration/invasion, and EMT while inhibiting apoptosis by sponging miR-138 to increase Sirt1, forming a hsa_circ_0006571/miR-138/Sirt1 regulatory axis that contributes to spinal metastasis in vivo."	0.7452
33490078	Frontiers in cell and developmental biology	2020	CircRNAs Dysregulated in Juvenile Myelomonocytic Leukemia: CircMCTP1 Stands Out.			hsa_circ_MCTP1	MCTP1	Juvenile myelomonocytic leukemia 	MONDO:0011908	juvenile myelomonocytic leukemia	up-regulated	RT-qPCR; RNA-seq	"circMCTP1(9_12) is strongly up-regulated in JMML and was confirmed by qRT-PCR in an independent cohort. Network analyses suggest it may act as a miRNA decoy for tumor-suppressor miRNAs (e.g., miR-138-5p, miR-638, miR-508-5p, miR-572, miR-8075), potentially contributing to de-repression of oncogenic target genes and related pathways."	0.5135
33490078	Frontiers in cell and developmental biology	2020	CircRNAs Dysregulated in Juvenile Myelomonocytic Leukemia: CircMCTP1 Stands Out.			hsa_circ_LYN	LYN	Juvenile myelomonocytic leukemia 	MONDO:0011908	juvenile myelomonocytic leukemia	up-regulated	RT-qPCR; RNA-seq	circLYN(5_8) is up-regulated in JMML versus healthy donors based on RNA-seq and qRT-PCR validation in an independent cohort. The study did not experimentally define its downstream mechanism or targets.	0.4773
33490078	Frontiers in cell and developmental biology	2020	CircRNAs Dysregulated in Juvenile Myelomonocytic Leukemia: CircMCTP1 Stands Out.			hsa_circ_AFF2	AFF2	Juvenile myelomonocytic leukemia 	MONDO:0011908	juvenile myelomonocytic leukemia	up-regulated	RT-qPCR; RNA-seq	"circAFF2 isoforms (circAFF2(3) and circAFF2(2_3)) are up-regulated in JMML versus healthy donors, supported by RNA-seq and qRT-PCR validation. No specific miRNA/mRNA targets or pathways were experimentally established for circAFF2 in this paper."	0.4773
33490078	Frontiers in cell and developmental biology	2020	CircRNAs Dysregulated in Juvenile Myelomonocytic Leukemia: CircMCTP1 Stands Out.			hsa_circ_ATM	ATM	Juvenile myelomonocytic leukemia 	MONDO:0011908	juvenile myelomonocytic leukemia	down-regulated	RT-qPCR; RNA-seq	circATM(2_4) is consistently down-regulated in JMML versus healthy donors in both RNA-seq and qRT-PCR validation cohorts. The paper does not establish a specific downstream molecular mechanism for circATM in JMML.	0.4773
33490078	Frontiers in cell and developmental biology	2020	CircRNAs Dysregulated in Juvenile Myelomonocytic Leukemia: CircMCTP1 Stands Out.			hsa_circ_OXNAD1	OXNAD1	Juvenile myelomonocytic leukemia 	MONDO:0011908	juvenile myelomonocytic leukemia	down-regulated	RT-qPCR; RNA-seq	"circOXNAD1(7_8) is consistently down-regulated in JMML compared with healthy donors, confirmed by RNA-seq and qRT-PCR. The study does not provide a specific downstream mechanism for circOXNAD1 in JMML."	0.4773
33490086	Frontiers in cell and developmental biology	2020	"Circular RNA CircNOLC1, Upregulated by NF-KappaB, Promotes the Progression of Prostate Cancer via miR-647/PAQR4 Axis."	hsa_circ_0000257	circNOLC1	hsa_circ_NOLC1	NOLC1	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; ISH; Microarray	"circNOLC1 is upregulated in prostate cancer and functions as an oncogenic circRNA. It sponges miR-647 to increase PAQR4 expression and thereby promotes PI3K/AKT pathway activation, enhancing proliferation, migration, tumor growth, and angiogenesis. NF-kappaB transcriptionally upregulates NOLC1 and circNOLC1 via binding the NOLC1 promoter."	0.894
33494070	Aging	2021	RNA interactions in right ventricular dysfunction induced type II cardiorenal syndrome.		mm9_circ_004072			right ventricular (RV) dysfunction induced type II cardiorenal syndrome 	MONDO:0044079	cardio-renal syndrome	up-regulated	RT-qPCR	"mm9_circ_004072 is significantly upregulated in right ventricular tissue in a PAC-induced mouse model of RV dysfunction-induced type II CRS. The study reports this as part of transcriptomic dysregulation, without a specific validated downstream mechanism for this circRNA."	0.4128
33494070	Aging	2021	RNA interactions in right ventricular dysfunction induced type II cardiorenal syndrome.		mm9_circ_007155			right ventricular (RV) dysfunction induced type II cardiorenal syndrome 	MONDO:0044079	cardio-renal syndrome	up-regulated	RT-qPCR	mm9_circ_007155 is significantly upregulated in right ventricular tissue in a PAC-induced mouse model of RV dysfunction-induced type II CRS. No specific interacting miRNA/mRNA axis is experimentally validated for this circRNA in the paper.	0.4128
33494070	Aging	2021	RNA interactions in right ventricular dysfunction induced type II cardiorenal syndrome.		Mm9_circ_010239			right ventricular (RV) dysfunction induced type II cardiorenal syndrome 	MONDO:0044079	cardio-renal syndrome	down-regulated	RT-qPCR	Mm9_circ_010239 is downregulated in kidney tissue in the PAC-induced mouse model of RV dysfunction-induced type II CRS. The paper does not provide a specific experimentally validated miRNA/mRNA mechanism for this circRNA.	0.4128
33494763	Cancer cell international	2021	Hsa_circ_0010235 functions as an oncogenic drive in non-small cell lung cancer by modulating miR-433-3p/TIPRL axis.	hsa_circ_0010235		hsa_circ_ALDH4A1	ALDH4A1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0010235 is up-regulated in NSCLC tissues and cell lines and promotes NSCLC malignant phenotypes. Mechanistically, it functions as a ceRNA by sponging miR-433-3p to upregulate TIPRL, thereby enhancing proliferation, autophagy, migration/invasion and tumor growth while inhibiting apoptosis. Clinically, higher hsa_circ_0010235 expression is associated with poorer overall survival."	0.8352
33495420	Aging	2021	Hsa_circ_0000199 facilitates chemo-tolerance of triple-negative breast cancer by interfering with miR-206/613-led PI3K/Akt/mTOR signaling.	hsa_circ_0000199	circRNA AKT3 	hsa_circ_AKT3	AKT3	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"hsa_circ_0000199 (AKT3-derived) is up-regulated in TNBC and promotes malignant phenotypes and chemoresistance. It sponges miR-206 and miR-613 to modulate PI3K/AKT/mTOR signaling, affecting proliferation, migration/invasion, chemosensitivity and autophagy, and its high expression predicts poor survival in TNBC patients."	0.7126
33498476	Cancers	2021	Genome-Wide Circular RNA Expression Patterns Reflect Resistance to Immunomodulatory Drugs in Multiple Myeloma Cells.		ciRS-7 	hsa_circ_LINC00632	LINC00632	multiple myeloma 	MONDO:0009693	plasma cell myeloma	down-regulated	RNA-seq	"ciRS-7 (CDR1as) is markedly down-regulated in acquired lenalidomide- and pomalidomide-resistant multiple myeloma cell models. Its loss correlates with hypermethylation of the LINC00632 T3 promoter CpG island and can be partially reversed by DNMT and EZH2 inhibition, but ciRS-7 knockdown alone does not change IMiD sensitivity."	0.4852
33498476	Cancers	2021	Genome-Wide Circular RNA Expression Patterns Reflect Resistance to Immunomodulatory Drugs in Multiple Myeloma Cells.		circIKZF3	hsa_circ_IKZF3	IKZF3	multiple myeloma 	MONDO:0009693	plasma cell myeloma	up-regulated	RNA-seq	"circIKZF3 is up-regulated in lenalidomide- and pomalidomide-resistant NCI-H929 multiple myeloma cells and its expression trend was validated by NanoString. Functional follow-up was not completed due to unsuccessful knockdown, so its role in IMiD resistance remains undetermined."	0.1768
33500381	Signal transduction and targeted therapy	2021	cFUT8 promotes liver cancer progression by miR-548c/FUT8 axis.		cFUT8	hsa_circ_FUT8	FUT8	Hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"cFUT8 is up-regulated in HCC and promotes malignant phenotypes (proliferation, invasion, metastasis, and EMT-related changes). Mechanistically, it predominantly localizes in the cytoplasm and sponges miR-548c, relieving miR-548c-mediated repression of FUT8 and thereby increasing FUT8 expression; high cFUT8 is associated with worse survival."	0.7859
33500536	Cancer gene therapy	2022	Circular RNA FLNA acts as a sponge of miR-486-3p in promoting lung cancer progression via regulating XRCC1 and CYP1A1.	hsa_circ_0092012	circFLNA	hsa_circ_FLNA	FLNA	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circFLNA (hsa_circ_0092012) is up-regulated in lung cancer tissues/cells and mainly localized in the cytoplasm. It promotes lung cancer cell proliferation, migration and invasion and enhances xenograft tumor growth by sponging miR-486-3p, leading to increased XRCC1 and CYP1A1 expression."	0.742
33500625	OncoTargets and therapy	2021	Circ_0067835 Knockdown Enhances the Radiosensitivity of Colorectal Cancer by miR-296-5p/IGF1R Axis.	hsa_circ_0067835	circ_0067835			colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0067835 is up-regulated in CRC tissues and in serum exosomes (especially after radiotherapy) and is associated with CRC development and radioresistance. Functionally, circ_0067835 promotes proliferation and cell-cycle progression and inhibits apoptosis, while its knockdown sensitizes CRC cells to irradiation in vitro and suppresses xenograft growth in vivo. Mechanistically, circ_0067835 acts as a ceRNA by sponging miR-296-5p to increase IGF1R expression (circ_0067835/miR-296-5p/IGF1R axis)."	0.6542
33500653	International journal of general medicine	2021	CircRNA_104565 Promoted Cell Proliferation in Papillary Thyroid Carcinoma by Sponging miR-134.		circRNA_104565			papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circRNA_104565 is up-regulated in papillary thyroid carcinoma tissues and cell lines and promotes PTC cell proliferation and xenograft growth. It functions as a ceRNA that sponges miR-134, thereby relieving repression of ELF2 and activating the miR-134/ELF2 axis."	0.6479
33500664	Cancer management and research	2021	CircSKA3 Downregulates miR-1 Through Methylation in Glioblastoma to Promote Cancer Cell Proliferation.		circSKA3	hsa_circ_SKA3	SKA3	glioblastoma 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR	"circSKA3 is up-regulated in glioblastoma and acts as an oncogenic circRNA by promoting GBM cell proliferation. Mechanistically, circSKA3 overexpression increases methylation of the miR-1 gene, leading to reduced miR-1 expression, and high circSKA3 expression is associated with poorer overall survival in GBM patients."	0.6866
33502747	"Reproductive sciences (Thousand Oaks, Calif.)"	2021	Decreased circUBAP2 Expression Is Associated with Preeclampsia by Limiting Trophoblast Cell Proliferation and Migration.	hsa_circ_0003496	circUBAP2	hsa_circ_UBAP2	UBAP2	Preeclampsia 	MONDO:0005081	preeclampsia	down-regulated	RT-qPCR	"circUBAP2 is down-regulated in placental tissues from preeclampsia patients. Functional assays show that circUBAP2 supports trophoblast proliferation and migration, and mechanistically acts as a ceRNA by sponging miR-1244 to regulate FOXM1; miR-1244 inhibition partially rescues the effects of circUBAP2 knockdown."	0.7795
33504681	Aging	2021	circRNA_141539 can serve as an oncogenic factor in esophageal squamous cell carcinoma by sponging miR-4469 and activating CDK3 gene.		circRNA_141539			esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circRNA_141539 is up-regulated in ESCC tissues and promotes ESCC cell proliferation and invasion. Mechanistically, it sponges miR-4469, relieving repression of CDK3 and activating CDK3 expression, and higher circRNA_141539 is associated with worse patient prognosis and diagnostic value."	0.8122
33505171	Cancer management and research	2021	Circ_0105346 Knockdown Inhibits Osteosarcoma Development via Regulating miR-1182/WNT7B Axis.	hsa_circ_0105346	circ_0105346 	hsa_circ_ASPHD1	ASPHD1	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"circ_0105346 is upregulated in osteosarcoma and functions as an oncogenic circRNA. It sponges miR-1182 to increase WNT7B expression, thereby promoting OS malignant behaviors (proliferation, migration/invasion, EMT-like changes, and glycolysis) and inhibiting apoptosis; its knockdown suppresses tumor growth in xenograft models and high expression correlates with worse overall survival."	0.7524
33505218	Mediators of inflammation	2021	circRNA circ_102049 Implicates in Pancreatic Ductal Adenocarcinoma Progression through Activating CD80 by Targeting miR-455-3p.	hsa_circ_0043278	circRNA_102049 	hsa_circ_TADA2A	TADA2A	Pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; Microarray	"In PDAC, circ_102049 (circTADA2A; hsa_circRNA_102049/hsa_circ_0043278) is up-regulated and mainly cytoplasmic. It promotes proliferation, migration/invasion and inflammatory factor expression while inhibiting apoptosis, partly by sponging miR-455-3p to upregulate CD80, and its knockdown suppresses tumor growth in a cell line-derived xenograft model."	0.7346
33506021	BioMed research international	2021	"Comprehensive Analysis of the Profiles of Differentially Expressed mRNAs, lncRNAs, and circRNAs in Phosgene-Induced Acute Lung Injury."		circRNA-3871			phosgene-induced acute lung injury 	MONDO:0003479	toxic pneumonitis	up-regulated	RNA-seq	"circRNA-3871 is up-regulated in phosgene-exposed rat lung tissue and is proposed (based on predicted binding sites/network analysis) to act as a miRNA sponge, particularly for miR-339, potentially influencing inflammation/apoptosis-related processes in ALI and MSC-mediated treatment."	0.31
33506021	BioMed research international	2021	"Comprehensive Analysis of the Profiles of Differentially Expressed mRNAs, lncRNAs, and circRNAs in Phosgene-Induced Acute Lung Injury."		circRNA-2246			phosgene-induced acute lung injury 	MONDO:0003479	toxic pneumonitis	unknown	RNA-seq	"circRNA-2246 is one of the significantly differentially expressed circRNAs in rat lung tissue in the phosgene-induced ALI study and was included in the predicted circRNA_miRNA network, with predicted binding to miR-149-5p/miR-296-3p/miR-3593-5p and shared targeting of miR-1956-5p."	0.31
33506021	BioMed research international	2021	"Comprehensive Analysis of the Profiles of Differentially Expressed mRNAs, lncRNAs, and circRNAs in Phosgene-Induced Acute Lung Injury."		circRNA-3868			phosgene-induced acute lung injury 	MONDO:0003479	toxic pneumonitis	unknown	RNA-seq	"circRNA-3868 was included among the significantly differentially expressed circRNAs between phosgene-exposed and MSC-treated rat groups and was incorporated into a predicted circRNA_miRNA interaction network, with predicted binding sites for miR-877/miR-357/miR-874-3p."	0.31
33506021	BioMed research international	2021	"Comprehensive Analysis of the Profiles of Differentially Expressed mRNAs, lncRNAs, and circRNAs in Phosgene-Induced Acute Lung Injury."		circRNA-3235			phosgene-induced acute lung injury 	MONDO:0003479	toxic pneumonitis	down-regulated	RNA-seq	"circRNA-3235 shows lower expression in phosgene-exposed rats compared with MSC-treated rats and is proposed to function as a miR-320 sponge based on predicted binding/network analysis, implicating it in ALI and MSC-related therapeutic effects."	0.31
33506107	"Open medicine (Warsaw, Poland)"	2021	"CircRNA circ_0004370 promotes cell proliferation, migration, and invasion and inhibits cell apoptosis of esophageal cancer via miR-1301-3p/COL1A1 axis."	hsa_circ_0004370	circ_0004370	hsa_circ_PRRX1	PRRX1	esophageal cancer 	MONDO:0007576	esophageal cancer	up-regulated	RT-qPCR	"circ_0004370 is up-regulated in esophageal cancer tissues/cells and functions as an oncogenic circRNA. It mainly localizes to the cytoplasm and promotes proliferation, migration, invasion, EMT, and xenograft tumor growth while inhibiting apoptosis by sponging miR-1301-3p to upregulate COL1A1."	0.7799
33506582	Thoracic cancer	2021	Propofol suppresses lung cancer tumorigenesis by modulating the circ-ERBB2/miR-7-5p/FOXM1 axis.	hsa_circ_0007766	circ-ERBB2 	hsa_circ_ERBB2	ERBB2	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; Microarray	"circ-ERBB2 is up-regulated in lung cancer tissues and cell lines, and propofol reduces its expression. Mechanistically, circ-ERBB2 sponges miR-7-5p to increase FOXM1, thereby promoting malignant phenotypes including proliferation, invasion and glycolysis and reducing apoptosis; circ-ERBB2 knockdown enhances propofol¡¯s antitumor effects in xenografts."	0.742
33508783	Aging	2021	CircMRE11A_013 binds to UBXN1 and integrates ATM activation enhancing lens epithelial cells senescence in age-related cataract.			hsa_circ_MRE11A	MRE11A	age-related cortical cataract 	MONDO:0001749	cortical senile cataract	up-regulated	RT-qPCR; Northern Blot	"circMRE11A (circMRE11A_013) is up-regulated in lens epithelial cells from ARCC patients and in UVB-treated SRA01/04 cells. It promotes senescence and G1/S arrest and reduces viability by binding UBXN1 to enhance ATM activation (ATM-S1981p), triggering the ATM/p53/p21 pathway, with evidence supporting a protein-scaffold mechanism rather than miRNA sponging."	0.8229
33509213	Cancer cell international	2021	Circ_0000020 elevates the expression of PIK3CA and facilitates the malignant phenotypes of glioma cells via targeting miR-142-5p.	hsa_circ_0000020	circ_0000020	hsa_circ_DDI2	DDI2	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ_0000020 (hsa_circ_0000020) is up-regulated in glioma tissues/cell lines and promotes glioma cell proliferation, migration/invasion and in vivo tumor growth/metastasis. Mechanistically, it acts as a ceRNA by sponging miR-142-5p to increase PIK3CA expression, and higher circ_0000020 correlates with worse overall survival and adverse clinicopathological features."	0.7126
33511111	Frontiers in cell and developmental biology	2020	Circular RNA hsa_circ_0004277 Stimulates Malignant Phenotype of Hepatocellular Carcinoma and Epithelial-Mesenchymal Transition of Peripheral Cells.	hsa_circ_0004277	circ-0004277 	hsa_circ_WDR37	WDR37	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"hsa_circ_0004277 (circ-0004277), derived from WDR37, is up-regulated in HCC tissues, HCC cell lines, and plasma exosomes, and promotes HCC proliferation, migration, EMT, and metastasis. Mechanistically, it binds the RBP HuR, interferes with HuR_ZO-1 mRNA interaction, suppresses ZO-1, and thereby enhances EMT. Exosomal circ-0004277 can be transferred to surrounding normal hepatic cells to stimulate EMT/migration, and it shows diagnostic potential by ROC analysis."	0.8202
33511909	Technology in cancer research & treatment	2021	Circ_0003998 Regulates the Progression and Docetaxel Sensitivity of DTX-Resistant Non-Small Cell Lung Cancer Cells by the miR-136-5p/CORO1C Axis.	hsa_circ_0003998	circ_0003998			non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0003998 is up-regulated in NSCLC, especially in docetaxel-resistant tissues/cells, and promotes chemoresistance, colony formation and tumor growth while inhibiting apoptosis. It functions as a ceRNA by sponging miR-136-5p to increase CORO1C expression, thereby reducing docetaxel sensitivity."	0.6825
33514777	Scientific reports	2021	A risk progression breast epithelial 3D culture model reveals Cx43/hsa_circ_0077755/miR-182 as a biomarker axis for heightened risk of breast cancer initiation.	hsa_circ_0007961		hsa_circ_SPRED2	SPRED2	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0007961 (from SPRED2) is significantly up-regulated upon Cx43 silencing in the S1/Cx43-KO-S1 3D risk-progression model. It was proposed to sponge several miRNAs, but the predicted inverse circRNA_miRNA pattern and patient-cohort support were lacking, so the axis was not validated for breast cancer initiation risk assessment."	0.5135
33514777	Scientific reports	2021	A risk progression breast epithelial 3D culture model reveals Cx43/hsa_circ_0077755/miR-182 as a biomarker axis for heightened risk of breast cancer initiation.	hsa_circ_0081481		hsa_circ_FBXO24	FBXO24	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0081481 (from FBXO24) is significantly up-regulated upon Cx43 silencing in the 3D risk-progression model. Although a circRNA_miRNA axis (including miR-3960/miR-8072) was proposed, it was not validated because patient-cohort miR-3960 expression contradicted the expected inverse pattern."	0.5135
33514777	Scientific reports	2021	A risk progression breast epithelial 3D culture model reveals Cx43/hsa_circ_0077755/miR-182 as a biomarker axis for heightened risk of breast cancer initiation.	hsa_circ_0060056		hsa_circ_EIF6	EIF6	breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	hsa_circ_0060056 (EIF6-derived) is significantly down-regulated after Cx43 silencing in the S1 3D breast epithelial risk-progression model. No specific downstream miRNA/mRNA mechanism or clinical relevance was further established for this circRNA in the study.	0.3401
33514777	Scientific reports	2021	A risk progression breast epithelial 3D culture model reveals Cx43/hsa_circ_0077755/miR-182 as a biomarker axis for heightened risk of breast cancer initiation.	hsa_circ_0083442		hsa_circ_MTUS1	MTUS1	breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	hsa_circ_0083442 (MTUS1-derived) is significantly down-regulated after Cx43 silencing in the S1 3D breast epithelial risk-progression model. The study did not further establish a specific mechanism or clinical implication for this circRNA.	0.3401
33514777	Scientific reports	2021	A risk progression breast epithelial 3D culture model reveals Cx43/hsa_circ_0077755/miR-182 as a biomarker axis for heightened risk of breast cancer initiation.	hsa_circ_0005185		hsa_circ_PRKD1	PRKD1	breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	hsa_circ_0005185 (PRKD1-derived) is significantly down-regulated after Cx43 silencing in the S1 3D breast epithelial risk-progression model. No specific downstream mechanism was established for this circRNA in the study.	0.3401
33514777	Scientific reports	2021	A risk progression breast epithelial 3D culture model reveals Cx43/hsa_circ_0077755/miR-182 as a biomarker axis for heightened risk of breast cancer initiation.	hsa_circ_0001072		hsa_circ_GTDC1	GTDC1	breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	hsa_circ_0001072 (GTDC1-derived) is significantly down-regulated after Cx43 silencing in the S1 3D breast epithelial risk-progression model. The study did not further investigate mechanistic targets or clinical associations for this circRNA.	0.3401
33514777	Scientific reports	2021	A risk progression breast epithelial 3D culture model reveals Cx43/hsa_circ_0077755/miR-182 as a biomarker axis for heightened risk of breast cancer initiation.	hsa_circ_0077753		hsa_circ_GJA1	GJA1	breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	hsa_circ_0077753 is a GJA1 (Cx43) derived circRNA isoform significantly down-regulated upon Cx43 silencing in the S1 3D culture model. The study did not establish a specific miRNA sponging axis or clinical association for this isoform.	0.1155
33514777	Scientific reports	2021	A risk progression breast epithelial 3D culture model reveals Cx43/hsa_circ_0077755/miR-182 as a biomarker axis for heightened risk of breast cancer initiation.	hsa_circ_0077754		hsa_circ_GJA1	GJA1	breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	hsa_circ_0077754 is a GJA1 (Cx43) derived circRNA isoform significantly down-regulated upon Cx43 silencing in the S1 3D culture model. The paper does not attribute a specific validated miRNA axis or clinical implication to this isoform.	0.1155
33514777	Scientific reports	2021	A risk progression breast epithelial 3D culture model reveals Cx43/hsa_circ_0077755/miR-182 as a biomarker axis for heightened risk of breast cancer initiation.	hsa_circ_0077755		hsa_circ_GJA1	GJA1	breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0077755 (GJA1/Cx43-derived) is significantly down-regulated upon Cx43 silencing in the S1 3D risk-progression model and forms the study¡¯s only validated risk-assessment axis with miR-182, consistent with a miRNA-sponging relationship. Bioinformatics analyses link the axis to cancer-related functions such as migration, invasion and proliferation, and the authors propose it as a biomarker signature for heightened risk of breast cancer initiation and prognosis patterns across progression."	0.6142
33516252	Journal of experimental & clinical cancer research : CR	2021	The circular RNA circZFR phosphorylates Rb promoting cervical cancer progression by regulating the SSBP1/CDK2/cyclin E1 complex.	hsa_circ_0072088	circZFR 	hsa_circ_ZFR	ZFR	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"circZFR (hsa_circ_0072088), derived from ZFR, is up-regulated in cervical cancer and promotes proliferation, G1/S transition, migration/invasion, and xenograft tumor growth. Mechanistically it binds the RBP SSBP1 to enhance SSBP1/CDK2/cyclin E1 complex assembly, increasing Rb phosphorylation (S807/S608) and activating E2F1-driven cell-cycle programs."	0.8712
33517886	BMC medicine	2021	Development and validation of a novel circular RNA as an independent prognostic factor in acute myeloid leukemia.	hsa_circ_0075451	circGMDS	hsa_circ_GMDS	GMDS	acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0075451 (circGMDS) is up-regulated in CN-AML patients with unfavorable outcome and serves as an independent prognostic factor; high expression predicts poorer overall survival. Mechanistically, it mainly localizes in the cytoplasm and acts as a ceRNA by sponging miR-330-5p and miR-326, thereby increasing PRDM16 expression, and its high expression is associated with distinct metabolic changes in bone marrow blasts."	0.8305
33519139	World journal of gastroenterology	2021	Circular RNA AKT3 governs malignant behaviors of esophageal cancer cells by sponging miR-17-5p.			hsa_circ_AKT3	AKT3	esophageal cancer	MONDO:0007576	esophageal cancer	up-regulated	RT-qPCR	"circAKT3 is up-regulated in esophageal cancer tissues and cell lines and promotes malignant behaviors (proliferation, migration, invasion) and xenograft tumor growth. Mechanistically, circAKT3 functions as a ceRNA by sponging miR-17-5p, thereby increasing RHOC and STAT3 expression."	0.6966
33519212	OncoTargets and therapy	2021	Circular RNA circSEC24A Promotes Cutaneous Squamous Cell Carcinoma Progression by Regulating miR-1193/MAP3K9 Axis.	hsa_circ_0003528	circSEC24A 	hsa_circ_SEC24A	SEC24A	cutaneous squamous cell carcinoma 	MONDO:0002529	skin squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circSEC24A is up-regulated in CSCC tissues/cells and functions as an oncogenic circRNA. It sponges miR-1193 to de-repress MAP3K9, thereby promoting proliferation, migration/invasion and glycolysis while inhibiting apoptosis; silencing circSEC24A suppresses xenograft tumor growth and is associated with better overall survival in patients with low circSEC24A."	0.8324
33520980	Frontiers in cell and developmental biology	2020	Circ0083429 Regulates Osteoarthritis Progression via the Mir-346/SMAD3 Axis.	hsa_circ_0083429	Circ0083429 	hsa_circ_SLC7A2	SLC7A2	Osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR; Northern Blot; ISH; RNA-seq	"Circ0083429 is down-regulated in osteoarthritic cartilage and mainly localizes to the cytoplasm of human chondrocytes. It protects ECM homeostasis and alleviates OA progression by acting as a ceRNA that sponges miR-346, thereby relieving repression of SMAD3 and modulating ECM-related genes (e.g., MMP3/MMP13/ADAMTS4, COL2A1, aggrecan)."	0.8527
33520987	Frontiers in cell and developmental biology	2020	Hsa_circ_0020095 Promotes Oncogenesis and Cisplatin Resistance in Colon Cancer by Sponging miR-487a-3p and Modulating SOX9.	hsa_circ_0020095		hsa_circ_ATRNL1	ATRNL1	colon cancer 	MONDO:0021063	malignant colon neoplasm	up-regulated	RT-qPCR; Northern Blot	"circ_0020095 (hsa_circ_0020095), derived from ATRNL1, is up-regulated in colon cancer tissues/cell lines and promotes proliferation, migration, invasion and cisplatin resistance while inhibiting apoptosis. It mainly functions as a cytoplasmic ceRNA that sponges miR-487a-3p to increase SOX9 (and also regulates Met via miR-338-3p), and its knockdown suppresses xenograft tumor growth."	0.8533
33526034	BMC cardiovascular disorders	2021	"CircTM7SF3 contributes to oxidized low-density lipoprotein-induced apoptosis, inflammation and oxidative stress through targeting miR-206/ASPH axis in atherosclerosis cell model in vitro."	hsa_circ_0007478	circTM7SF3	hsa_circ_TM7SF3	TM7SF3	Atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"In atherosclerosis serum samples and ox-LDL-treated macrophage models, circTM7SF3 is up-regulated and aggravates ox-LDL-induced macrophage injury (reduced viability, increased apoptosis, inflammation, and oxidative stress). Mechanistically, circTM7SF3 sponges miR-206 to increase ASPH expression, forming a circTM7SF3/miR-206/ASPH axis."	0.8107
33530981	Molecular cancer	2021	CircNR3C2 promotes HRD1-mediated tumor-suppressive effect via sponging miR-513a-3p in triple-negative breast cancer.	hsa_circ_0071127	CircNR3C2	hsa_circ_NR3C2	NR3C2	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	down-regulated	RT-qPCR	"circNR3C2 is down-regulated in TNBC and mainly localized in the cytoplasm. It suppresses TNBC growth and metastasis by sponging miR-513a-3p, thereby relieving miRNA-mediated repression of HRD1 and enhancing HRD1-driven ubiquitin-proteasome degradation of Vimentin, inhibiting EMT-related malignant phenotypes."	0.8571
33531835	Cancer management and research	2021	Circular RNA CircCDYL Regulates Proliferation and Apoptosis in Non-Small Cell Lung Cancer Cells by Sponging miR-185-5p and Upregulating TNRC6A.		CircCDYL	hsa_circ_CDYL	CDYL	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"circCDYL is down-regulated in NSCLC tissues, plasma, and cell lines. Functionally, circCDYL suppresses proliferation/viability, induces apoptosis and cell-cycle arrest in A549 cells. Mechanistically, it sponges miR-185-5p to upregulate TNRC6A and inhibit ERK1/2 signaling."	0.7552
33531839	Cancer management and research	2021	Circ_0035483 Functions as a Tumor Promoter in Renal Cell Carcinoma via the miR-31-5p-Mediated HMGA1 Upregulation.	hsa_circ_0035483	Circ_0035483			Renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR	"circ_0035483 is up-regulated in RCC tissues/cells and functions as an oncogenic circRNA. It sponges miR-31-5p to relieve repression of HMGA1, thereby promoting proliferation, migration/invasion, EMT, glycolysis, and xenograft tumor growth."	0.7087
33531841	Cancer management and research	2021	Circ_0031242 Silencing Mitigates the Progression and Drug Resistance in DDP-Resistant Hepatoma Cells by the miR-924/POU3F2 Axis.	hsa_circ_0031242	circ_0031242 	hsa_circ_PRMT5	PRMT5	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0031242 (circ_PRMT5) is up-regulated in HCC, especially in DDP-resistant recurrent tumors and DDP-resistant cell lines. It promotes cisplatin resistance and malignant phenotypes by sponging miR-924 to increase POU3F2 expression, and its knockdown sensitizes xenografts to DDP."	0.6825
33532293	Translational andrology and urology	2021	Identification of a potentially functional circRNA-miRNA-mRNA ceRNA regulatory network in bladder cancer by analysis of microarray data.	hsa_circ_0023642				bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	Microarray	"In bladder cancer, has_circ_0023642 was identified as an up-regulated circRNA from a GEO microarray dataset. The study predicts it may function as a ceRNA by sponging miRNAs (notably miR-616/miR-616-3p) and thereby influencing expression of downstream mRNAs including hub genes such as CENPA and HIST1H3H."	0.1768
33532293	Translational andrology and urology	2021	Identification of a potentially functional circRNA-miRNA-mRNA ceRNA regulatory network in bladder cancer by analysis of microarray data.	hsa_circ_0047322				bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	Microarray	"In bladder cancer, has_circ_0047322 was identified as an up-regulated circRNA from microarray analysis. The study predicts a ceRNA role for has_circ_0047322, particularly via binding hsa-miR-515-5p and linking to hub genes such as CENPA and multiple HIST1H* genes within a circRNA-miRNA-mRNA network."	0.1768
33532293	Translational andrology and urology	2021	Identification of a potentially functional circRNA-miRNA-mRNA ceRNA regulatory network in bladder cancer by analysis of microarray data.	hsa_circ_0041151				bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	Microarray	"In bladder cancer, has_circ_0041151 was identified as an up-regulated circRNA from a GEO microarray dataset. The study predicts it participates in a ceRNA network, including a has_circ_0041151_hsa-miR-1178-3p_CENPA regulatory axis, potentially affecting mRNA expression programs relevant to BCa progression."	0.1768
33534779	Aging	2021	Circular RNA circEPSTI1 accelerates cervical cancer progression via miR-375/409-3P/515-5p-SLC7A11 axis.	hsa_circ_0000479	circEPSTI1 	hsa_circ_EPSTI1	EPSTI1	cervical cancer	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circEPSTI1 is up-regulated in cervical cancer cell lines and promotes proliferation and xenograft tumor growth. Mechanistically, it acts as a ceRNA that sponges miR-375/miR-409-3P/miR-515-5p to increase SLC7A11, thereby inhibiting ferroptosis (reduced lipid peroxidation and maintained GSH/GPX4). It is proposed as a potential biomarker and therapeutic target in cervical cancer."	0.7081
33536022	Cancer cell international	2021	circ-ANXA7 facilitates lung adenocarcinoma progression via miR-331/LAD1 axis.		circ-ANXA7	hsa_circ_ANXA7	ANXA7	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circ-ANXA7 is up-regulated in LUAD and promotes LUAD cell proliferation, migration and invasion and enhances tumor growth. Mechanistically, circ-ANXA7 sponges miR-331 to relieve repression of LAD1, forming a circ-ANXA7/miR-331/LAD1 axis. High circ-ANXA7 expression is associated with poorer overall survival and it serves as an independent prognostic factor."	0.8157
33536026	World journal of surgical oncology	2021	Hsa_circ_0025202 suppresses cell tumorigenesis and tamoxifen resistance via miR-197-3p/HIPK3 axis in breast cancer.	hsa_circ_0025202		hsa_circ_GADPH	GADPH	breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	"hsa_circ_0025202 is down-regulated in breast cancer tissues and especially in tamoxifen-resistant breast cancer cells. Functionally, it suppresses malignant phenotypes and tamoxifen resistance by sponging miR-197-3p and thereby restoring HIPK3 expression, improving tamoxifen sensitivity in vitro and in xenograft tumors."	0.6833
33536745	"Drug design, development and therapy"	2021	CircNRIP1 Modulates the miR-515-5p/IL-25 Axis to Control 5-Fu and Cisplatin Resistance in Nasopharyngeal Carcinoma.	hsa_circ_0004771	CircNRIP1	hsa_circ_NRIP1	NRIP1	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"CircNRIP1 is up-regulated in the serum of chemoresistant NPC patients and in cisplatin-resistant NPC cell models. It promotes 5-Fu and cisplatin resistance by sponging miR-515-5p to derepress IL-25, and high serum circNRIP1 is associated with worse overall survival."	0.7283
33536787	Cancer management and research	2021	CircRNA hsa_circ_0005909 Promotes Cell Proliferation of Osteosarcoma Cells by Targeting miR-338-3p/HMGA1 Axis.	hsa_circ_0005909	circ_0005909 			Osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"In osteosarcoma, circ_0005909 (hsa_circ_0005909) is up-regulated and promotes OS cell proliferation. It functions as a ceRNA that sponges miR-338-3p to increase HMGA1 expression, thereby activating ERK/MAPK and PI3K/AKT signaling."	0.7759
33536789	Cancer management and research	2021	Circular RNA Circ_0006282 Promotes Cell Proliferation and Metastasis in Gastric Cancer by Regulating MicroRNA-144-5p/Tyrosine 3-Monooxygenase/Tryptophan 5-Monooxygenase Activation Protein beta Axis.	hsa_circ_0006282	circ_0006282	hsa_circ_TCEB1	TCEB1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_0006282 is upregulated in gastric cancer tissues and cell lines, mainly localized in the cytoplasm, and promotes GC cell proliferation and metastatic phenotypes. Mechanistically, it acts as a ceRNA by sponging miR-144-5p to increase YWHAB expression; knockdown suppresses tumor growth in a nude mouse xenograft model."	0.7827
33537815	Molecular medicine reports	2021	Circ_TOP2A acts as a ceRNA for miR_346 and contributes to glioma progression via the modulation of sushi domain_containing 2.	hsa_circ_0043548	circ-TOP2A 	hsa_circ_TOP2A	TOP2A	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ-TOP2A is up-regulated in glioma tissues and cell lines and predicts poor survival. It promotes proliferation/viability, migration and invasion while inhibiting apoptosis by acting as a ceRNA that sponges miR-346 to increase SUSD2 expression (circ-TOP2A/miR-346/SUSD2 axis)."	0.8554
33539420	PLoS pathogens	2021	CircRNA ARFGEF1 functions as a ceRNA to promote oncogenic KSHV-encoded viral interferon regulatory factor induction of cell invasion and angiogenesis by upregulating glutaredoxin 3.	hsa_circ_0001808	circARFGEF1	hsa_circ_ARFGEF1	ARFGEF1	Kaposi¡¯s sarcoma 	MONDO:0005055	Kaposi's sarcoma	up-regulated	RT-qPCR; RNA-seq	"circARFGEF1 is up-regulated by KSHV vIRF1 via Lef1-mediated transcriptional activation and promotes endothelial oncogenic phenotypes (migration/invasion, proliferation, angiogenesis). It functions as a ceRNA by binding and destabilizing miR-125a-3p, thereby de-repressing the miR-125a-3p target GLRX3."	0.8507
33542659	Cancer management and research	2021	CircRNA_0000429 Regulates Development of NSCLC by Acting as a Sponge of miR-1197 to Control MADD.	hsa_circ_0000429	CircRNA_0000429 			Non-small-cell lung carcinoma 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0000429 is up-regulated in NSCLC tissues and cell lines and promotes NSCLC cell proliferation, migration/invasion, tumor growth and metastasis while inhibiting apoptosis. Mechanistically, it predominantly localizes in the cytoplasm and functions as a ceRNA by sponging miR-1197, thereby increasing MADD expression."	0.7635
33543830	Cancer medicine	2021	Circ-UBAP2 functions as sponges of miR-1205 and miR-382 to promote glioma progression by modulating STC1 expression.	hsa_circ_0008344	circ-UBAP2	hsa_circ_UBAP2	UBAP2	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ-UBAP2 is up-regulated in glioma and promotes malignant phenotypes (proliferation, migration, invasion) while suppressing apoptosis. It functions mainly in the cytoplasm as a miRNA sponge for miR-1205 and miR-382, thereby relieving miRNA-mediated repression of GPRC5A and enhancing tumor growth in a cell line-derived xenograft model."	0.7421
33544410	Journal of cellular and molecular medicine	2021	Identification of novel dysregulated circular RNAs in early-stage breast cancer.	hsa_circ_0006743	circJMJD1C	hsa_circ_JMJD1C	JMJD1C	early-stage breast cancer 	MONDO:0004658	breast carcinoma in situ	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0006743 (circJMJD1C) is significantly up-regulated in early-stage breast cancer tissues and was validated by RT-qPCR in clinical samples. The study proposes its potential diagnostic relevance, but does not experimentally define a downstream mechanism or axis for this circRNA."	0.585
33544410	Journal of cellular and molecular medicine	2021	Identification of novel dysregulated circular RNAs in early-stage breast cancer.	hsa_circ_0002496	circAPPBP1	hsa_circ_APPBP1	APPBP1	early-stage breast cancer 	MONDO:0004658	breast carcinoma in situ	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0002496 (circAPPBP1) is up-regulated in early-stage breast cancer tissues and was validated by RT-qPCR in clinical samples. Co-expression analysis suggests it may sponge miR-125B1, miR-204 and miR-10B, but the regulatory relationship is not experimentally validated in this study."	0.585
33544410	Journal of cellular and molecular medicine	2021	Identification of novel dysregulated circular RNAs in early-stage breast cancer.	hsa_circ_0023990		hsa_circ_NOX4	NOX4	early-stage breast cancer 	MONDO:0004658	breast carcinoma in situ	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0023990 is reported as up-regulated in early-stage breast cancer based on RNA-seq analysis and is suggested to interact with hsa-miR-548b-3p from co-expression and binding-site prediction. RT-qPCR was performed but did not show statistically significant up-regulation, so evidence strength is limited."	0.585
33545359	Molecular therapy : the journal of the American Society of Gene Therapy	2021	circEHBP1 promotes lymphangiogenesis and lymphatic metastasis of bladder cancer via miR-130a-3p/TGFbetaR1/VEGF-D signaling.	hsa_circ_0005552	circEHBP1	hsa_circ_EHBP1	EHBP1	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; RNA-seq	"circEHBP1 is up-regulated in bladder cancer and promotes lymphangiogenesis and lymphatic (LN) metastasis. Mechanistically, it sponges miR-130a-3p to de-repress TGFBR1, activating TGF-beta/SMAD3 signaling and increasing VEGF-D secretion; high circEHBP1 associates with worse OS/DFS."	0.8818
33552082	Frontiers in immunology	2020	Integrated Analysis of circRNA-miRNA-mRNA Regulatory Networks in the Intestine of Sebastes schlegelii Following Edwardsiella tarda Challenge.		novel_circ_0004195 			Edwardsiella tarda infection 	MONDO:1014977		down-regulated	RT-qPCR; RNA-seq	"novel_circ_0004195 is downregulated after E. tarda infection and is proposed to participate in a ceRNA network with novel_530 affecting IkappaB, thereby influencing activation of NF-kappaB signaling and intestinal immune barrier function."	0.4851
33552082	Frontiers in immunology	2020	Integrated Analysis of circRNA-miRNA-mRNA Regulatory Networks in the Intestine of Sebastes schlegelii Following Edwardsiella tarda Challenge.		novel_circ_0003210			Edwardsiella tarda infection 	MONDO:1014977		unknown	RNA-seq	"novel_circ_0003210 is implicated in an infection-responsive circRNA-miRNA-mRNA network with novel_152 and apoptosis-stimulating of p53 protein 1, and is proposed to regulate p53 signaling to promote cell cycle arrest and apoptosis during E. tarda infection."	0.4375
33552082	Frontiers in immunology	2020	Integrated Analysis of circRNA-miRNA-mRNA Regulatory Networks in the Intestine of Sebastes schlegelii Following Edwardsiella tarda Challenge.		novel_circ_0001907			Edwardsiella tarda infection 	MONDO:1014977		up-regulated	RNA-seq	"novel_circ_0001907 is upregulated (notably at 6 h post-infection) and is part of a predicted ceRNA network with novel_127 and interleukin-1 receptor type 2, potentially contributing to intestinal immune responses during E. tarda infection."	0.4375
33552272	Oncology letters	2021	Hsa_circ_0001696 modulates cell proliferation and migration in colorectal cancer.	hsa_circ_0001696		hsa_circ_HERPUD2	HERPUD2	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"hsa_circ_0001696 is down-regulated in colorectal cancer tissues. Functionally, its knockdown promotes CRC cell proliferation, colony formation, and migration, accompanied by increased CDK4/cyclin D/cyclin E and MMP9 levels, suggesting a tumor-suppressive role."	0.5414
33552886	Journal of bone oncology	2021	Circular RNA circANKIB1 promotes the progression of osteosarcoma by regulating miR-217/PAX3 axis.	hsa_circ_0009112	circANKIB1	hsa_circ_ANKIB1	ANKIB1	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circANKIB1 is up-regulated in osteosarcoma tissues and cell lines and functions as an oncogenic circRNA. It promotes OS cell proliferation, migration/invasion, EMT and tumor growth by sponging miR-217 to relieve repression of PAX3 (circANKIB1/miR-217/PAX3 ceRNA axis)."	0.7597
33552887	Journal of bone oncology	2021	Down-regulation of circular RNA hsa_circ_0007534 suppresses cell growth by regulating miR-219a-5p/SOX5 axis in osteosarcoma.	hsa_circ_0007534	circ_0007534			osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"hsa_circ_0007534 (circ_0007534) is up-regulated in osteosarcoma tissues and cell lines and functions as an oncogenic circRNA. It promotes OS proliferation, migration/invasion, EMT and tumor growth by sponging miR-219a-5p, leading to increased SOX5 expression."	0.7548
33552974	Frontiers in oncology	2020	"circ_NOTCH3 Functions as a Protooncogene Competing With miR-205-5p, Modulating KLF12 Expression and Promoting the Development and Progression of Basal-Like Breast Carcinoma."	hsa_circ_0109177	circ_NOTCH3 	hsa_circ_NOTCH3	NOTCH3	basal-like breast carcinoma 	MONDO:0004984	basal-like breast carcinoma	up-regulated	RT-qPCR; Microarray	"circ_NOTCH3 is up-regulated in BLBC tissues and cells and promotes malignant phenotypes (proliferation, migration, invasion) while inhibiting apoptosis. Mechanistically, it functions as a ceRNA by sponging miR-205-5p, thereby relieving repression of KLF12 and promoting BLBC progression."	0.6815
33553144	Frontiers in cell and developmental biology	2020	Progression Risk Assessment of Post-surgical Papillary Thyroid Carcinoma Based on Circular RNA-Associated Competing Endogenous RNA Mechanisms.	hsa_circ_0003645		hsa_circ_C16orf62	C16orf62	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	Microarray	"Identified as an upregulated DE-circRNA in PTC within a PFI-related ceRNA subnetwork. It is predicted to act as a miRNA sponge (hsa-miR-139-3p), thereby potentially contributing to PTC progression via downstream mRNA targets in the ceRNA network."	0.4032
33553144	Frontiers in cell and developmental biology	2020	Progression Risk Assessment of Post-surgical Papillary Thyroid Carcinoma Based on Circular RNA-Associated Competing Endogenous RNA Mechanisms.	hsa_circ_0089153		hsa_circ_NUP214	NUP214	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	Microarray	"hsa_circ_0089153 is upregulated in PTC and is included in the PFI-related ceRNA subnetwork. It is predicted to sponge hsa-miR-139-3p, thereby increasing SPC24 and CDKN2A expression and potentially promoting PTC progression."	0.4032
33553144	Frontiers in cell and developmental biology	2020	Progression Risk Assessment of Post-surgical Papillary Thyroid Carcinoma Based on Circular RNA-Associated Competing Endogenous RNA Mechanisms.	hsa_circ_0005699		hsa_circ_C16orf62	C16orf62	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	Microarray	"hsa_circ_0005699 is upregulated in PTC and part of the PFI-related ceRNA subnetwork. It is predicted to sponge hsa-miR-139-3p, thereby increasing SPC24 and CDKN2A expression and potentially promoting PTC progression."	0.4032
33553144	Frontiers in cell and developmental biology	2020	Progression Risk Assessment of Post-surgical Papillary Thyroid Carcinoma Based on Circular RNA-Associated Competing Endogenous RNA Mechanisms.	hsa_circ_0007146		hsa_circ_NAGPA	NAGPA	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	Microarray	hsa_circ_0007146 is predicted to be upregulated in PTC and included in the PFI-related ceRNA subnetwork. It may promote PTC progression by sponging hsa-miR-139-3p within the ceRNA framework.	0.4032
33553144	Frontiers in cell and developmental biology	2020	Progression Risk Assessment of Post-surgical Papillary Thyroid Carcinoma Based on Circular RNA-Associated Competing Endogenous RNA Mechanisms.	hsa_circ_0038718		hsa_circ_IL4R	IL4R	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	Microarray	hsa_circ_0038718 is upregulated in PTC and part of the PFI-related ceRNA subnetwork. It is predicted to act as a sponge for hsa-miR-139-3p and may contribute to oncogenic progression-related regulation in PTC.	0.4032
33553144	Frontiers in cell and developmental biology	2020	Progression Risk Assessment of Post-surgical Papillary Thyroid Carcinoma Based on Circular RNA-Associated Competing Endogenous RNA Mechanisms.	hsa_circ_0001658		hsa_circ_ARID1B	ARID1B	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	Microarray	"hsa_circ_0001658 is upregulated in PTC and included in the PFI-related ceRNA subnetwork. It is predicted to sponge hsa-miR-139-5p and thereby relieve repression of RIMS2, potentially promoting PTC progression."	0.4032
33553144	Frontiers in cell and developmental biology	2020	Progression Risk Assessment of Post-surgical Papillary Thyroid Carcinoma Based on Circular RNA-Associated Competing Endogenous RNA Mechanisms.	hsa_circ_0008784		hsa_circ_TNFRSF19	TNFRSF19	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	Microarray	"hsa_circ_0008784 is upregulated in PTC and included in the PFI-related ceRNA subnetwork. It is predicted to sponge hsa-miR-139-5p, potentially leading to increased RIMS2 expression and promoting oncogenic progression features in PTC."	0.4032
33553144	Frontiers in cell and developmental biology	2020	Progression Risk Assessment of Post-surgical Papillary Thyroid Carcinoma Based on Circular RNA-Associated Competing Endogenous RNA Mechanisms.	hsa_circ_0000965		hsa_circ_C19orf18	C19orf18	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	Microarray	"hsa_circ_0000965 is upregulated in PTC and included in the PFI-related ceRNA subnetwork. It is predicted to sponge hsa-miR-139-5p and may increase RIMS2 expression, contributing to oncogenic progression in PTC."	0.4032
33553144	Frontiers in cell and developmental biology	2020	Progression Risk Assessment of Post-surgical Papillary Thyroid Carcinoma Based on Circular RNA-Associated Competing Endogenous RNA Mechanisms.	hsa_circ_0001917		hsa_circ_CASK	CASK	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	Microarray	"hsa_circ_0001917 is upregulated in PTC and included in the PFI-related ceRNA subnetwork. It is predicted to sponge hsa-miR-139-5p and increase RIMS2 expression, potentially promoting PTC progression."	0.4032
33553144	Frontiers in cell and developmental biology	2020	Progression Risk Assessment of Post-surgical Papillary Thyroid Carcinoma Based on Circular RNA-Associated Competing Endogenous RNA Mechanisms.	hsa_circ_0008354		hsa_circ_WTIP	WTIP	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	Microarray	"hsa_circ_0008354 is downregulated in PTC and part of the PFI-related ceRNA subnetwork. It is predicted to sponge hsa-miR-146b-3p and is associated in the network with regulation of CLCNKB, FBXO27, and FXYD6."	0.4032
33553144	Frontiers in cell and developmental biology	2020	Progression Risk Assessment of Post-surgical Papillary Thyroid Carcinoma Based on Circular RNA-Associated Competing Endogenous RNA Mechanisms.	hsa_circ_0049271		hsa_circ_KEAP1	KEAP1	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	Microarray	"hsa_circ_0049271 is downregulated in PTC and included in the PFI-related ceRNA subnetwork. It is predicted to sponge hsa-miR-146b-3p and is associated in the network with regulation of CLCNKB, FBXO27, and FXYD6."	0.4032
33560542	Cancer science	2021	Identification of circular RNAs as novel biomarkers and potentially functional competing endogenous RNA network for myelodysplastic syndrome patients.		hsa_circRNA_100352	hsa_circ_ASH1L	ASH1L	myelodysplastic syndrome 	MONDO:0018881	myelodysplastic syndrome	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_100352 is up-regulated in bone marrow from MDS patients and shows diagnostic value by ROC analysis. Higher expression is associated with poorer overall survival, and bioinformatic predictions suggest it may act in a circRNA_miRNA_mRNA ceRNA network relevant to MDS development."	0.7151
33560542	Cancer science	2021	Identification of circular RNAs as novel biomarkers and potentially functional competing endogenous RNA network for myelodysplastic syndrome patients.		hsa_circRNA_104056	hsa_circ_RREB1	RREB1	myelodysplastic syndrome 	MONDO:0018881	myelodysplastic syndrome	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_104056 is up-regulated in MDS bone marrow, shows strong diagnostic performance (highest AUC among the six circRNAs), and its high expression predicts poorer overall survival. It is included in a predicted circRNA_miRNA_mRNA ceRNA network that may relate to MDS pathogenesis."	0.7151
33560542	Cancer science	2021	Identification of circular RNAs as novel biomarkers and potentially functional competing endogenous RNA network for myelodysplastic syndrome patients.		hsa_circRNA_104634	hsa_circ_ASPH	ASPH	myelodysplastic syndrome 	MONDO:0018881	myelodysplastic syndrome	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_104634 is up-regulated in MDS bone marrow and was RT-qPCR-validated. It shows potential diagnostic value by ROC analysis, but no significant overall survival association was reported."	0.6605
33560542	Cancer science	2021	Identification of circular RNAs as novel biomarkers and potentially functional competing endogenous RNA network for myelodysplastic syndrome patients.		hsa_circRNA_103846	hsa_circ_DEPDC1B	DEPDC1B	myelodysplastic syndrome 	MONDO:0018881	myelodysplastic syndrome	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_103846 is down-regulated in MDS bone marrow and was RT-qPCR-validated. It has potential diagnostic value by ROC analysis, but no significant overall survival association was reported."	0.6605
33560542	Cancer science	2021	Identification of circular RNAs as novel biomarkers and potentially functional competing endogenous RNA network for myelodysplastic syndrome patients.		hsa_circRNA_102817	hsa_circ_SAP130	SAP130	myelodysplastic syndrome 	MONDO:0018881	myelodysplastic syndrome	down-regulated	RT-qPCR; Microarray	hsa_circRNA_102817 is down-regulated in MDS bone marrow and is a diagnostic and prognostic biomarker: higher expression is linked to poorer overall survival. It was used to build a predicted circRNA_miRNA_mRNA ceRNA network suggesting roles in MDS-related processes such as cell cycle and p53 signaling (enrichment-based).	0.7151
33560542	Cancer science	2021	Identification of circular RNAs as novel biomarkers and potentially functional competing endogenous RNA network for myelodysplastic syndrome patients.		hsa_circRNA_102526	hsa_circ_UBA2	UBA2	myelodysplastic syndrome 	MONDO:0018881	myelodysplastic syndrome	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_102526 is down-regulated in MDS bone marrow and was RT-qPCR-validated. It has potential diagnostic value by ROC analysis, but no significant overall survival association was reported."	0.6605
33560588	Journal of cellular and molecular medicine	2022	CircCSNK1G3 up-regulates miR-181b to promote growth and metastasis via TIMP3-mediated epithelial to mesenchymal transitions in renal cell carcinoma.	hsa_circ_0001522	circCSNK1G3	hsa_circ_CSNK1G3	CSNK1G3	renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circCSNK1G3 (hsa_circ_0001522), derived from CSNK1G3, is up-regulated in RCC and predominantly localized in the cytoplasm. It promotes RCC cell proliferation, migration/invasion and in vivo tumor growth by directly interacting with and up-regulating miR-181b, which suppresses tumor suppressors (notably TIMP3) and enhances EMT, leading to metastasis-related phenotypes."	0.8207
33562358	International journal of molecular sciences	2021	The GAUGAA Motif Is Responsible for the Binding between circSMARCA5 and SRSF1 and Related Downstream Effects on Glioblastoma Multiforme Cell Migration and Angiogenic Potential.		circSMARCA5	hsa_circ_SMARCA5	SMARCA5	glioblastoma multiforme 	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR; Northern Blot	"circSMARCA5 is down-regulated in GBM and functions as a tumor-suppressive RBP decoy for SRSF1. Disrupting its GAUGAA motif weakens SRSF1 binding and increases GBM cell migration and pro-angiogenic activity, associated with altered VEGFA isoform balance and increased extracellular VEGFA mRNA."	0.7513
33563314	Journal of ovarian research	2021	"Propofol suppresses cell viability, cell cycle progression and motility and induces cell apoptosis of ovarian cancer cells through suppressing MEK/ERK signaling via targeting circVPS13C/miR-145 axis."		circVPS13C 	hsa_circ_VPS13C	VPS13C	ovarian cancer	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circVPS13C is up-regulated in ovarian cancer tissues/cell lines and directly binds (sponges) miR-145, leading to reduced miR-145. Under propofol treatment, circVPS13C down-regulation elevates miR-145 and suppresses MEK/ERK signaling, thereby inhibiting proliferation/cell-cycle progression/migration/invasion and promoting apoptosis in ovarian cancer cells."	0.779
33568625	Cell death & disease	2021	circST6GALNAC6 suppresses bladder cancer metastasis by sponging miR-200a-3p to modulate the STMN1/EMT axis.	hsa_circ_0088708	circST6GALNAC6	hsa_circ_ST6GALNAC6	ST6GALNAC6	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; ISH; Microarray	"circST6GALNAC6 (hsa_circ_0088708), derived from ST6GALNAC6, is down-regulated in bladder cancer tissues and cell lines. Its overexpression suppresses proliferation, migration/invasion, EMT and lung metastasis by sponging miR-200a-3p to release STMN1, with upstream transcriptional activation by SP1."	0.8794
33568942	Cancer management and research	2021	Hsa_circ_0043278 Inhibits Tumorigenesis and is Downregulated in Colorectal Cancer.	hsa_circ_0043278	hsa_circTADA2A_011	hsa_circ_TADA2A	TADA2A	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0043278 is downregulated in colorectal cancer tissues and cell lines and functions as a tumor suppressor by inhibiting proliferation and migration while promoting apoptosis and G0/G1 arrest. Mechanistically, it sponges miR-192-3p (validated by dual-luciferase assay) and shows moderate diagnostic potential (AUC 0.71)."	0.7855
33569293	Translational lung cancer research	2021	Circ-AASDH functions as the progression of early stage lung adenocarcinoma by targeting miR-140-3p to activate E2F7 expression.	hsa_circ_0126678	Circ-AASDH 	hsa_circ_AASDH	AASDH	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circ-AASDH is up-regulated in LUAD tissues and cell lines and promotes malignant phenotypes (proliferation, migration, tumor growth) while reducing apoptosis. Mechanistically, it functions as a ceRNA that sponges miR-140-3p, thereby derepressing E2F7 and promoting LUAD progression; high circ-AASDH is associated with larger tumors, higher clinical stage, and poorer overall survival."	0.8465
33569895	FEBS open bio	2021	Circular RNA profiles and the potential involvement of down-expression of hsa_circ_0001360 in cutaneous squamous cell carcinogenesis.	hsa_circ_0000932				cutaneous squamous cell carcinoma 	MONDO:0002529	skin squamous cell carcinoma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0000932 was experimentally confirmed (qRT-PCR) to be significantly down-regulated in cSCC tumor tissues compared with adjacent nontumorous tissues.	0.5909
33569895	FEBS open bio	2021	Circular RNA profiles and the potential involvement of down-expression of hsa_circ_0001360 in cutaneous squamous cell carcinogenesis.	hsa_circ_0001360	circRNA_0001360 	hsa_circ_PHC3	PHC3	cutaneous squamous cell carcinoma 	MONDO:0002529	skin squamous cell carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001360 is significantly down-regulated in cSCC tissues. Functionally, it acts as a tumor-suppressive circRNA in SCL-1 cells by inhibiting proliferation/colony formation, migration and invasion and by promoting apoptosis, with a predicted ceRNA network involving five miRNAs and many downstream mRNAs (potentially related to PI3K/AKT signaling)."	0.7507
33571015	Cell transplantation	2021	CircRNA Circ-ITCH Inhibits the Proliferation and Invasion of Glioma Cells Through Targeting the miR-106a-5p/SASH1 Axis.		Circ-ITCH 	hsa_circ_ITCH	ITCH	glioma	MONDO:0021042	glioma	down-regulated	RT-qPCR	"circ-ITCH is down-regulated in glioma tissues and cell lines. Its overexpression suppresses glioma proliferation, invasion, and xenograft tumor growth by sponging miR-106a-5p and thereby increasing SASH1 expression."	0.6261
33573240	International journal of molecular sciences	2021	"Novel Identified Circular Transcript of RCAN2, circ-RCAN2, Shows Deviated Expression Pattern in Pig Reperfused Infarcted Myocardium and Hypoxic Porcine Cardiac Progenitor Cells In Vitro."		Circ-RCAN2	ssc_circ_RCAN2	RCAN2	acute myocardial infarction 	MONDO:0004781	acute myocardial infarction	down-regulated	RT-qPCR; RNA-seq	"circ-RCAN2 (a novel circular transcript from RCAN2) is significantly down-regulated in reperfused infarcted pig myocardium versus healthy control tissue, but is up-regulated in hypoxic porcine cardiac progenitor cells in an ischemia-time-dependent manner. The study establishes its existence and differential regulation in MI-related in vivo and hypoxia-related in vitro contexts without defining a specific downstream molecular axis."	0.6521
33573240	International journal of molecular sciences	2021	"Novel Identified Circular Transcript of RCAN2, circ-RCAN2, Shows Deviated Expression Pattern in Pig Reperfused Infarcted Myocardium and Hypoxic Porcine Cardiac Progenitor Cells In Vitro."		circ-C12orf29 	ssc_circ_C12orf29	C12orf29	acute myocardial infarction 	MONDO:0004781	acute myocardial infarction	down-regulated	RT-qPCR; RNA-seq	"circ-C12orf29 is significantly down-regulated in reperfused infarcted pig myocardium compared with healthy control myocardium and was selected for follow-up hypoxia experiments, where it showed no significant differential expression in pCPCs."	0.6521
33574702	Cancer management and research	2021	CircRNA ZNF609 Knockdown Represses the Development of Non-Small Cell Lung Cancer via miR-623/FOXM1 Axis.	hsa_circ_0000615	circZNF609 	hsa_circ_ZNF609	ZNF609	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circZNF609 is up-regulated in NSCLC and its high expression is associated with worse overall survival. Functionally, circZNF609 promotes NSCLC cell growth and metastatic behaviors and inhibits apoptosis, at least partly by sponging miR-623 to upregulate FOXM1; circZNF609 knockdown suppresses xenograft tumor growth."	0.7751
33574707	Cancer management and research	2021	Anti-Tumor Effect of Celastrol on Hepatocellular Carcinoma by the circ_SLIT3/miR-223-3p/CXCR4 Axis.	hsa_circ_0074903	circ_SLIT3	hsa_circ_SLIT3	SLIT3	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_SLIT3 is up-regulated in HCC tissues/cells and promotes malignant phenotypes. Celastrol suppresses HCC progression partly by down-regulating circ_SLIT3, which functions as a ceRNA to sponge miR-223-3p and thereby increase CXCR4 expression, affecting proliferation, migration/invasion and apoptosis, including in a Hep3B xenograft model."	0.7856
33574834	Frontiers in genetics	2021	Five Circular RNAs in Metabolism Pathways Related to Prostate Cancer.	hsa_circ_0006410		hsa_circ_TUSC3	TUSC3	Prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0006410 is up-regulated in prostate cancer tissues and was validated by qRT-PCR. The study predicts it may act as a miRNA sponge and be associated with PCa-related pathways including MAPK, PI3K/AKT, and lipid-related processes, suggesting potential as a metabolic biomarker."	0.4032
33574834	Frontiers in genetics	2021	Five Circular RNAs in Metabolism Pathways Related to Prostate Cancer.	hsa_circ_0003970		hsa_circ_DOCK1	DOCK1	Prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0003970 is up-regulated in prostate cancer tissues and was validated by qRT-PCR. The work predicts it participates in a circRNA_miRNA_mRNA network and links it to PCa-related pathways (e.g., MAPK, PI3K/AKT, lipid-related processes), supporting its potential as a metabolic biomarker."	0.4032
33574834	Frontiers in genetics	2021	Five Circular RNAs in Metabolism Pathways Related to Prostate Cancer.	hsa_circ_0006754		hsa_circ_UTRN	UTRN	Prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0006754 is up-regulated in prostate cancer tissues and was validated by qRT-PCR. It is predicted to function via a circRNA_miRNA_mRNA interaction network and is linked to PCa-related pathways including MAPK and lipid-related processes, implying potential biomarker relevance."	0.4032
33574834	Frontiers in genetics	2021	Five Circular RNAs in Metabolism Pathways Related to Prostate Cancer.		hsa_circ_AKAP7	hsa_circ_AKAP7	AKAP7	Prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; RNA-seq	"The novel circRNA hsa_circ_AKAP7 is up-regulated in prostate cancer tissues and was validated by qRT-PCR. It is computationally linked to a circRNA_miRNA_mRNA regulatory network and PCa-relevant pathways (MAPK, PI3K/AKT, lipid-related processes), suggesting possible metabolic biomarker potential."	0.4032
33574968	Disease markers	2021	Differentially Expressed Circular RNA Profile in an Intracranial Aneurysm Group Compared with a Healthy Control Group.		hsa_circRNA_000139			Intracranial aneurysm 	MONDO:0005291	brain aneurysm	dysregulated	RT-qPCR; Microarray	"hsa_circRNA_000139 was identified as a differentially expressed circRNA in blood from IA patients versus controls and its dysregulation was validated by RT-qPCR. The study further predicted circRNA_miRNA interactions and implicated enriched pathways (including mTOR signaling) at the level of the differentially expressed circRNA set, without providing a specific downstream miRNA/target for this circRNA."	0.4032
33574968	Disease markers	2021	Differentially Expressed Circular RNA Profile in an Intracranial Aneurysm Group Compared with a Healthy Control Group.		hsa_circRNA_101321			Intracranial aneurysm 	MONDO:0005291	brain aneurysm	dysregulated	RT-qPCR; Microarray	"hsa_circRNA_101321 was among five circRNAs selected from the microarray results and validated by RT-qPCR as differentially expressed in IA patient blood versus controls. The paper only provided predicted circRNA_miRNA networks and pathway enrichment at the set level, without specifying a unique downstream mechanism for this circRNA."	0.4032
33574968	Disease markers	2021	Differentially Expressed Circular RNA Profile in an Intracranial Aneurysm Group Compared with a Healthy Control Group.		hsa_circRNA_072697			Intracranial aneurysm 	MONDO:0005291	brain aneurysm	dysregulated	RT-qPCR; Microarray	"hsa_circRNA_072697 was validated by RT-qPCR as a differentially expressed circRNA in IA patient blood compared with controls. Mechanistic links were limited to predicted circRNA_miRNA networks and enrichment of pathways (including mTOR signaling) across the differentially expressed circRNA set, not specifically for this circRNA."	0.4032
33574968	Disease markers	2021	Differentially Expressed Circular RNA Profile in an Intracranial Aneurysm Group Compared with a Healthy Control Group.		hsa_circRNA_069101			Intracranial aneurysm 	MONDO:0005291	brain aneurysm	dysregulated	RT-qPCR; Microarray	"hsa_circRNA_069101 was experimentally validated (RT-qPCR) as differentially expressed in IA versus control blood samples. The study linked the overall differentially expressed circRNA profile to predicted circRNA_miRNA networks and enriched pathways such as mTOR signaling, but did not report a dedicated mechanism for this specific circRNA."	0.4032
33574968	Disease markers	2021	Differentially Expressed Circular RNA Profile in an Intracranial Aneurysm Group Compared with a Healthy Control Group.		hsa_circRNA_103677			Intracranial aneurysm 	MONDO:0005291	brain aneurysm	dysregulated	RT-qPCR; Microarray	"hsa_circRNA_103677 was validated by RT-qPCR as differentially expressed in IA patient blood versus controls. The study performed predicted circRNA_miRNA network and pathway enrichment analyses (including mTOR signaling) for the differentially expressed circRNA set, but did not provide circRNA-specific targets for hsa_circRNA_103677."	0.4032
33576439	Molecular medicine reports	2021	NFIB promotes the progression of gastric cancer by upregulating circMAP7D1 to stabilize HER2 mRNA.	hsa_circ_0004093	circMAP7D1 	hsa_circ_MAP7D1	MAP7D1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circMAP7D1 is up-regulated in gastric cancer tissues and cells. It promotes GC cell proliferation and cell-cycle progression and inhibits apoptosis. Mechanistically, NFIB upregulates circMAP7D1, which binds HER2 and increases HER2 mRNA stability, contributing to tumor progression."	0.7592
33576448	International journal of molecular medicine	2021	CircUSP36 knockdown alleviates oxidized low_density lipoprotein_induced cell injury and inflammatory responses in human umbilical vein endothelial cells via the miR_20a_5p/ROCK2 axis.	hsa_circ_0003204	circUSP36 	hsa_circ_USP36	USP36	atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"circUSP36 is up-regulated in ox-LDL-treated HUVECs (an in vitro atherosclerosis model) and promotes ox-LDL-induced endothelial injury and inflammation. Functionally, circUSP36 knockdown reduces cell cycle arrest, apoptosis, and inflammatory cytokines and restores migration/invasion. Mechanistically, circUSP36 sponges miR-20a-5p to derepress ROCK2 (circUSP36/miR-20a-5p/ROCK2)."	0.5998
33579337	Journal of experimental & clinical cancer research : CR	2021	Circ_0119872 promotes uveal melanoma development by regulating the miR-622/G3BP1 axis and downstream signalling pathways.	hsa_circ_0119872	circ_0119872	hsa_circ_RASGRP3	RASGRP3	uveal melanoma 	MONDO:0006486	uveal melanoma	up-regulated	RT-qPCR; Microarray	"circ_0119872 is upregulated in uveal melanoma and functions as an oncogenic circRNA by promoting UM cell proliferation, angiogenesis, and xenograft tumor growth. Mechanistically, it sponges miR-622 to de-repress G3BP1, leading to activation of Wnt/beta-catenin and mTOR signaling."	0.8385
33579365	Stem cell research & therapy	2021	Circular RNA TTC3 regulates cerebral ischemia-reperfusion injury and neural stem cells by miR-372-3p/TLR4 axis in cerebral infarction.		circRNA TTC3 		TTC3	stroke 	MONDO:0005098	stroke disorder	up-regulated	RT-qPCR	"circTTC3 is upregulated in MCAO/R mouse brains and OGD-treated astrocytes, where it exacerbates ischemia/reperfusion-related injury. Mechanistically, circTTC3 sponges miR-372-3p to regulate TLR4, thereby promoting astrocyte injury and suppressing NSC proliferation/differentiation; miR-372-3p inhibition or TLR4 overexpression reverses the effects of circTTC3 knockdown."	0.5634
33584097	OncoTargets and therapy	2021	Circular RNA circARPP21 Acts as a Sponge of miR-543 to Suppress Hepatocellular Carcinoma by Regulating LIFR.	hsa_circ_0123629	circARPP21	hsa_circ_ARPP21	ARPP21	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"circARPP21 (hsa_circ_0123629) is downregulated in hepatocellular carcinoma and functions as a tumor suppressor by sponging miR-543, thereby relieving miR-543-mediated repression of LIFR. Increasing circARPP21 inhibits HCC cell proliferation, migration, and invasion, and low circARPP21 expression is associated with worse clinical features and prognosis."	0.8658
33584827	Frontiers in genetics	2021	"Comprehensive Analysis of Differentially Expressed lncRNA, circRNA and mRNA and Their ceRNA Networks in Mice With Severe Acute Pancreatitis."		CircAmy2a5	mmu_circ_Amy2a5		severe acute pancreatitis 	MONDO:0006515	acute pancreatitis	down-regulated	RT-qPCR; RNA-seq	"CircAmy2a5 was identified as significantly down-regulated in pancreatic tissue from SAP mice versus controls and its expression change was validated by RT-qPCR, consistent with RNA-seq."	0.4625
33584827	Frontiers in genetics	2021	"Comprehensive Analysis of Differentially Expressed lncRNA, circRNA and mRNA and Their ceRNA Networks in Mice With Severe Acute Pancreatitis."		CircZFP644	mmu_circ_ZFP644	ZFP644	severe acute pancreatitis 	MONDO:0006515	acute pancreatitis	down-regulated	RT-qPCR; RNA-seq	"CircZFP644 is down-regulated in SAP mouse pancreatic tissue and was validated by RT-qPCR. It is implicated in a ceRNA network by sponging miRNAs (e.g., miR-6929-3p) to regulate targets such as Cdh22, and is linked to calcium signal transduction and Notch/EPS-related regulation in SAP."	0.3684
33584827	Frontiers in genetics	2021	"Comprehensive Analysis of Differentially Expressed lncRNA, circRNA and mRNA and Their ceRNA Networks in Mice With Severe Acute Pancreatitis."		CircDTNB	mmu_circ_DTNB	DTNB	severe acute pancreatitis 	MONDO:0006515	acute pancreatitis	down-regulated	RT-qPCR; RNA-seq	"CircDTNB is down-regulated in SAP mouse pancreatic tissue and validated by RT-qPCR. It is proposed to act as a miRNA sponge (miR-6938-3p) to regulate Calb1, linking it to calcium signal transduction in SAP."	0.3684
33584827	Frontiers in genetics	2021	"Comprehensive Analysis of Differentially Expressed lncRNA, circRNA and mRNA and Their ceRNA Networks in Mice With Severe Acute Pancreatitis."		CircCELA3b	mmu_circ_CELA3b	CELA3b	severe acute pancreatitis 	MONDO:0006515	acute pancreatitis	down-regulated	RT-qPCR; RNA-seq	CircCELA3b was identified as significantly down-regulated in SAP mouse pancreatic tissue versus controls and validated by RT-qPCR; no specific ceRNA axis or functional mechanism was reported for CircCELA3b in this paper.	0.3213
33584827	Frontiers in genetics	2021	"Comprehensive Analysis of Differentially Expressed lncRNA, circRNA and mRNA and Their ceRNA Networks in Mice With Severe Acute Pancreatitis."		CircARHGEF38 	mmu_circ_ARHGEF38	ARHGEF38	severe acute pancreatitis 	MONDO:0006515	acute pancreatitis	down-regulated	RT-qPCR; RNA-seq	"CircARHGEF38 is down-regulated in SAP mouse pancreatic tissue and validated by RT-qPCR. In the circRNA-miRNA-mRNA network it is predicted to sponge miR-710 and regulate Atp2c1, potentially affecting calcium ion transport and calcium signal transduction in SAP."	0.3684
33584827	Frontiers in genetics	2021	"Comprehensive Analysis of Differentially Expressed lncRNA, circRNA and mRNA and Their ceRNA Networks in Mice With Severe Acute Pancreatitis."		CircSRPK2	mmu_circ_SRPK2	SRPK2	severe acute pancreatitis 	MONDO:0006515	acute pancreatitis	down-regulated	RT-qPCR; RNA-seq	"CircSRPK2 is down-regulated in SAP mouse pancreatic tissue and validated by RT-qPCR. It is implicated in ceRNA regulation (e.g., sponging miR-653-3p to regulate Gulp1) and is associated with apoptosis and autophagy regulation as well as intracellular calcium release (via miR-7081-5p/Tmem38b) in SAP."	0.3684
33584828	Frontiers in genetics	2021	Enrichment of Circular RNA Expression Deregulation at the Transition to Recurrent Spontaneous Seizures in Experimental Temporal Lobe Epilepsy.		circ_Arhgap4 	rno_circ_Arhgap4	Arhgap4	mesial temporal lobe epilepsy 	MONDO:0005115	temporal lobe epilepsy	up-regulated	RT-qPCR; RNA-seq	"In the rat PPS model of temporal lobe epilepsy, circ_Arhgap4 is significantly up-regulated at the day of first spontaneous seizure (DOFS). The study proposes a circ_Arhgap4_miR-6328_Drd2 regulatory network in which increased circ_Arhgap4 may sequester miR-6328 and thereby increase expression of miRNA target genes such as Drd2, potentially contributing to early epileptogenesis/TLE pathophysiology."	0.5971
33584828	Frontiers in genetics	2021	Enrichment of Circular RNA Expression Deregulation at the Transition to Recurrent Spontaneous Seizures in Experimental Temporal Lobe Epilepsy.		circ_Nav3 	rno_circ_Nav3	Nav3	mesial temporal lobe epilepsy 	MONDO:0005115	temporal lobe epilepsy	up-regulated	RT-qPCR; RNA-seq	"In the rat PPS model of temporal lobe epilepsy, circ_Nav3 is significantly up-regulated at DOFS. The study links circ_Nav3 to a predicted miR-10b-3p-centered circRNA/miRNA/mRNA network (with predicted targets including Tll1), suggesting a potential role in early epileptogenesis."	0.5971
33585208	Frontiers in oncology	2020	Hsa_circ_0107593 Suppresses the Progression of Cervical Cancer via Sponging hsa-miR-20a-5p/93-5p/106b-5p.	hsa_circ_0107593		hsa_circ_ABCA5	ABCA5	cervical cancer 	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR	"hsa_circ_0107593 is down-regulated in cervical cancer tissues and cell lines and functions as a tumor suppressor by inhibiting proliferation, migration, and invasion. Mechanistically, it sponges hsa-miR-20a-5p, hsa-miR-93-5p, and hsa-miR-106b-5p, and shows diagnostic potential by ROC analysis."	0.7113
33588586	Cell transplantation	2021	Circ SMARCA5 Inhibited Tumor Metastasis by Interacting with SND1 and Downregulating the YWHAB Gene in Cervical Cancer.		circ SMARCA5 	hsa_circ_SMARCA5	SMARCA5	cervical cancer	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR	"circ SMARCA5 is down-regulated in cervical cancer tissues/cell lines. Its overexpression suppresses proliferation, invasion, and in vivo tumor growth/metastasis while promoting apoptosis, mechanistically by binding the RBP SND1 and reducing SND1-mediated YWHAB upregulation."	0.7045
33591945	Aging	2021	Circ_ 0115744 acts as miR-144 sponge to promote and predict the metastasis of colorectal cancer.	hsa_circ_0115744	circ_0115744 			colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circ_0115744 is up-regulated in CRC, particularly in CRC with liver metastasis, and can distinguish CRLM from non-metastatic CRC using plasma-based risk score/ROC analysis. It promotes CRC cell invasion and metastasis by sponging miR-144, thereby relieving miR-144-mediated repression of EZH2 and increasing EZH2 expression."	0.824
33593338	Cancer cell international	2021	Circular RNA CDR1as promotes tumor progression by regulating miR-432-5p/E2F3 axis in pancreatic cancer.		circular RNA CDR1as 	hsa_circ_CDR1AS	CDR1as	pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; Microarray	"circCDR1as is up-regulated in pancreatic cancer tissues and cell lines and promotes malignant phenotypes. Mechanistically, it sponges miR-432-5p, thereby increasing E2F3 expression and enhancing proliferation, migration/invasion, and xenograft tumor growth while reducing apoptosis."	0.6835
33596920	World journal of surgical oncology	2021	Circ_0082182 promotes oncogenesis and metastasis of colorectal cancer in vitro and in vivo by sponging miR-411 and miR-1205 to activate the Wnt/beta-catenin pathway.	hsa_circ_0082182	circ_0082182			colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0082182 is up-regulated in colorectal cancer and its high expression is associated with worse overall survival. It promotes proliferation, cell-cycle progression, migration/invasion, EMT and tumor growth by sponging miR-411 and miR-1205 to activate Wnt/beta-catenin signaling."	0.7372
33598424	Frontiers in oncology	2020	Circular RNA circ_0014717 Suppresses Hepatocellular Carcinoma Tumorigenesis Through Regulating miR-668-3p/BTG2 Axis.	hsa_circ_0014717	circ_0014717			hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"circ_0014717 is down-regulated in HCC tissues and cell lines and functions as a tumor suppressor. Mechanistically, it sponges miR-668-3p to relieve repression of BTG2, thereby inhibiting proliferation/migration/invasion and suppressing xenograft tumor growth; higher circ_0014717 expression is associated with better survival outcomes."	0.7795
33603167	Oncogene	2021	Porcine model elucidates function of p53 isoform in carcinogenesis and reveals novel circTP53 RNA.		circTP53 	ssc_circ_TP53	TP53	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circTP53 (including variants circTP53-1 to -4, with circTP53-3 highly expressed in bone) is significantly up-regulated in porcine osteosarcoma compared with matched healthy bone. Overexpression of circTP53-3 in pig OS cells increases cell proliferation, while the downstream molecular mechanism is not yet defined."	0.6145
33603395	OncoTargets and therapy	2021	"Baicalein Represses Cervical Cancer Cell Growth, Cell Cycle Progression and Promotes Apoptosis via Blocking AKT/mTOR Pathway by the Regulation of circHIAT1/miR-19a-3p Axis."		circHIAT1 	hsa_circ_HIAT1	HIAT1	cervical cancer 	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR	"circHIAT1 is downregulated in cervical cancer tissues/cells but is induced by baicalein. It suppresses CC malignant behaviors by sponging miR-19a-3p and contributing to AKT/mTOR pathway inactivation, thereby inhibiting proliferation/cell cycle progression and promoting apoptosis, including reduced xenograft tumor growth."	0.705
33603460	Cancer management and research	2021	CircRNA circYY1 (hsa_circ_0101187) Modulates Cell Glycolysis and Malignancy Through Regulating YY1 Expression by Sponging miR-769-3p in Breast Cancer.	hsa_circ_0101187	circYY1	hsa_circ_YY1	YY1	Breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circYY1 (hsa_circ_0101187), derived from the YY1 gene, is up-regulated in breast cancer tissues/cells and associated with worse patient survival. Functionally, circYY1 promotes malignant phenotypes and glycolysis, and in vivo knockdown suppresses xenograft growth. Mechanistically, circYY1 mainly localizes in the cytoplasm and acts as a ceRNA by sponging miR-769-3p to increase YY1 expression."	0.8197
33603471	Cancer management and research	2021	"Circ_0056285 Regulates Proliferation, Apoptosis and Glycolysis of Osteosarcoma Cells via miR-1244/TRIM44 Axis."	hsa_circ_0056285	circ_0056285 	hsa_circ_RALB	RALB	Osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	circ_0056285 is up-regulated in osteosarcoma tissues/cells and mainly localizes to the cytoplasm. It promotes osteosarcoma cell proliferation and glycolysis and inhibits apoptosis by acting as a ceRNA that sponges miR-1244 to increase TRIM44 expression; its knockdown suppresses xenograft growth and exosomal circ_0056285 shows diagnostic potential.	0.8735
33603482	Cancer management and research	2021	"CircGDI2 Regulates the Proliferation, Migration, Invasion and Apoptosis of OSCC via miR-454-3p/FOXF2 Axis."	hsa_circ_0005379	circGDI2 	hsa_circ_GDI2	GDI2	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR	"circGDI2 is down-regulated in OSCC and suppresses malignant phenotypes (proliferation, migration, invasion) while promoting apoptosis. Mechanistically, it sponges miR-454-3p to relieve repression of FOXF2, forming a circGDI2/miR-454-3p/FOXF2 axis that inhibits tumor growth in vivo."	0.7416
33603770	Frontiers in genetics	2021	Circ_0065149 Alleviates Oxidized Low-Density Lipoprotein-Induced Apoptosis and Inflammation in Atherosclerosis by Targeting miR-330-5p.	hsa_circ_0065149	circ_0065149			atherosclerosis	MONDO:0005311	atherosclerosis	down-regulated	RT-qPCR	"circ_0065149 is down-regulated in ox-LDL-injured HUVECs and exerts a protective role by reducing apoptosis and inflammatory cytokine production while improving viability and motility. Mechanistically, it sponges miR-330-5p and suppresses NF-kappaB p65 nuclear translocation, thereby inhibiting NF-kappaB_associated inflammatory responses."	0.5634
33603847	Experimental and therapeutic medicine	2021	Circular RNA expression profile in human primary multiple intracranial aneurysm.	hsa_circ_0135895		hsa_circ_PTK2	PTK2	primary multiple intracranial aneurysm 	MONDO:0005291	brain aneurysm	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0135895 is up-regulated in PBMCs from patients with primary multiple intracranial aneurysm and was RT-qPCR-validated. The study predicts it participates in MIA pathogenesis via a ceRNA mechanism, sponging miRNAs to regulate PTK2 in the leukocyte transendothelial migration-related network."	0.5135
33603847	Experimental and therapeutic medicine	2021	Circular RNA expression profile in human primary multiple intracranial aneurysm.	hsa_circ_0000682				primary multiple intracranial aneurysm 	MONDO:0005291	brain aneurysm	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000682 is down-regulated in PBMCs from patients with primary multiple intracranial aneurysm and was RT-qPCR-validated as significantly different between cases and controls. It is predicted to act as a miRNA sponge in a ceRNA network related to leukocyte transendothelial migration, thereby regulating PRKCB."	0.5135
33603847	Experimental and therapeutic medicine	2021	Circular RNA expression profile in human primary multiple intracranial aneurysm.	hsa_circ_0000690		hsa_circ_ITGAL		primary multiple intracranial aneurysm 	MONDO:0005291	brain aneurysm	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000690 is down-regulated in PBMCs from patients with primary multiple intracranial aneurysm and was RT-qPCR-validated as significantly different between cases and controls. The study predicts it affects leukocyte transendothelial migration via a ceRNA network, acting as a miRNA sponge to regulate ITGAL (CD11a)."	0.5135
33612481	Aging	2021	Overexpression of hsa_circ_0002874 promotes resistance of non-small cell lung cancer to paclitaxel by modulating miR-1273f/MDM2/p53 pathway.	hsa_circ_0002874				non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0002874 is upregulated in NSCLC tissues and is associated with paclitaxel resistance. Mechanistically, it functions as a ceRNA by sponging miR-1273f to modulate the MDM2/P53 signaling, thereby affecting apoptosis and chemosensitivity; knockdown of hsa_circ_0002874 (or miR-1273f overexpression) reverses PTX resistance in vitro and in xenograft models."	0.7126
33613709	Oncology letters	2021	Hsa_circ_0076305 induces migration-proliferation dichotomy in gastric cancer.	hsa_circ_0076305	circPGC	hsa_circ_PGC	PGC	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"In gastric cancer, circPGC (hsa_circ_0076305) is down-regulated in tumors and decreases further in advanced stages. In AGS cells, circPGC overexpression suppresses proliferation but promotes migration/invasion and EMT-like changes, accompanied by increased MMP9/MMP14/Collagen I and reduced EGFR/PCNA/c-Myc/E-cadherin."	0.5751
33613755	Journal of Cancer	2021	circ_SMAD2 regulate colorectal cancer cells proliferation through targeting miR-1258/RPN2 signaling pathway.	hsa_circ_0000847	circ_SMAD2 	hsa_circ_SMAD2	SMAD2	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"In colorectal cancer, circ_SMAD2 (hsa_circ_0000847) is up-regulated and promotes proliferation, invasion, and in vivo tumor growth. It mainly acts as a ceRNA by sponging miR-1258, thereby increasing RPN2 expression and driving CRC progression."	0.8539
33614229	Molecular therapy. Nucleic acids	2021	circRNA hsa_circ_0018414 inhibits the progression of LUAD by sponging miR-6807-3p and upregulating DKK1.	hsa_circ_0018414	circ_0018414 	hsa_circ_DKK1	DKK1	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR	"hsa_circ_0018414 (circ_0018414), derived from DKK1, is down-regulated in LUAD and functions as a tumor suppressor. It mainly localizes to the cytoplasm and acts as a ceRNA by sponging miR-6807-3p to relieve repression of DKK1, thereby inhibiting Wnt/beta-catenin signaling and reducing proliferation/stemness while promoting apoptosis; low circ_0018414 is associated with worse overall survival."	0.8748
33614231	Molecular therapy. Nucleic acids	2021	circFOXM1 contributes to sorafenib resistance of hepatocellular carcinoma cells by regulating MECP2 via miR-1324.	hsa_circ_0025039		hsa_circ_FOXM1	FOXM1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circFOXM1 is up-regulated in HCC, especially in sorafenib-resistant tissues/cells, and its high level correlates with worse prognosis. Functionally, circFOXM1 promotes sorafenib resistance and malignant phenotypes by acting as a ceRNA that sponges miR-1324 to increase MECP2 expression."	0.8625
33614234	Molecular therapy. Nucleic acids	2021	Circular RNA circPSD3 alleviates hepatic fibrogenesis by regulating the miR-92b-3p/Smad7 axis.	mmu_circ_0001682				hepatic fibrosis 	MONDO:0100430	fibrotic liver disease	down-regulated	RT-qPCR	"circPSD3 is down-regulated in hepatic fibrosis (CCl4-induced mouse HF and human HF tissues). Functionally it suppresses hepatic stellate cell activation and proliferation and alleviates fibrogenesis. Mechanistically, circPSD3 acts as a miR-92b-3p sponge to upregulate Smad7 (circPSD3/miR-92b-3p/Smad7 axis)."	0.82
33614234	Molecular therapy. Nucleic acids	2021	Circular RNA circPSD3 alleviates hepatic fibrogenesis by regulating the miR-92b-3p/Smad7 axis.	hsa_circ_0002111	circPSD3 	hsa_circ_PSD3	PSD3	hepatic fibrosis 	MONDO:0100430	fibrotic liver disease	down-regulated	RT-qPCR	"circPSD3 is down-regulated in hepatic fibrosis (CCl4-induced mouse HF and human HF tissues). Functionally it suppresses hepatic stellate cell activation and proliferation and alleviates fibrogenesis. Mechanistically, circPSD3 acts as a miR-92b-3p sponge to upregulate Smad7 (circPSD3/miR-92b-3p/Smad7 axis)."	0.82
33614236	Molecular therapy. Nucleic acids	2021	Circular RNA RBPMS inhibits bladder cancer progression via miR-330-3p/RAI2 regulation.	hsa_circ_0006539	circRBPMS 	hsa_circ_RBPMS	RBPMS	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; ISH; RNA-seq	"circRBPMS (hsa_circ_0006539), derived from RBPMS, is down-regulated in bladder cancer and functions as a tumor suppressor. It sponges miR-330-3p to upregulate RAI2, thereby inhibiting ERK signaling and EMT, which suppresses proliferation, migration/invasion and metastasis and promotes apoptosis. Low circRBPMS expression is associated with aggressive clinicopathologic features and poorer survival, suggesting biomarker/therapeutic potential."	0.8824
33614247	Molecular therapy. Nucleic acids	2021	"hsa_circNFXL1_009 modulates apoptosis, proliferation, migration, and potassium channel activation in pulmonary hypertension."			hsa_circ_NFXL1	NFXL1	pulmonary arterial hypertension 	MONDO:0015924	pulmonary arterial hypertension	down-regulated	RT-qPCR; Microarray	"hsa_circNFXL1_009 is down-regulated in PAH-COPD blood and in hypoxia-treated hPASMCs. Its overexpression counteracts hypoxia-induced hPASMC proliferation, migration, and apoptotic resistance by sponging hsa-miR-29b-2-5p and upregulating KCNB1, thereby increasing whole-cell K+ currents."	0.8244
33614247	Molecular therapy. Nucleic acids	2021	"hsa_circNFXL1_009 modulates apoptosis, proliferation, migration, and potassium channel activation in pulmonary hypertension."			hsa_circ_MFN2	MFN2	pulmonary arterial hypertension 	MONDO:0015924	pulmonary arterial hypertension	down-regulated	RT-qPCR; Microarray	hsa_circMFN2_004 is significantly down-regulated in PAH-COPD patient whole blood and shows moderate diagnostic performance by ROC analysis (AUC 0.7472). No functional or mechanistic experiments were reported for this circRNA in the study.	0.4679
33614247	Molecular therapy. Nucleic acids	2021	"hsa_circNFXL1_009 modulates apoptosis, proliferation, migration, and potassium channel activation in pulmonary hypertension."			hsa_circ_ZNF302	ZNF302	pulmonary arterial hypertension 	MONDO:0015924	pulmonary arterial hypertension	down-regulated	RT-qPCR; Microarray	has_circ_ZNF302 is significantly down-regulated in PAH-COPD patient whole blood and demonstrates relatively high diagnostic performance among validated circRNAs by ROC analysis (AUC 0.8476). No downstream functional/mechanistic studies were reported for this circRNA.	0.4679
33614247	Molecular therapy. Nucleic acids	2021	"hsa_circNFXL1_009 modulates apoptosis, proliferation, migration, and potassium channel activation in pulmonary hypertension."			hsa_circ_GSDMD	GSDMD	pulmonary arterial hypertension 	MONDO:0015924	pulmonary arterial hypertension	up-regulated	RT-qPCR; Microarray	hsa_circGSDMD_004 is significantly up-regulated in PAH-COPD patient whole blood and has modest ROC performance (AUC 0.7316). The study did not further investigate its biological function or mechanism.	0.4679
33614247	Molecular therapy. Nucleic acids	2021	"hsa_circNFXL1_009 modulates apoptosis, proliferation, migration, and potassium channel activation in pulmonary hypertension."			hsa_circ_WDR37	WDR37	pulmonary arterial hypertension 	MONDO:0015924	pulmonary arterial hypertension	up-regulated	RT-qPCR; Microarray	hsa_circWDR37_016 is significantly up-regulated in PAH-COPD patient whole blood and shows good diagnostic performance by ROC analysis (AUC 0.8225). The study did not report mechanistic or functional validation for this circRNA.	0.4679
33614250	Molecular therapy. Nucleic acids	2021	Hypoxic tumor-derived exosomal circular RNA SETDB1 promotes invasive growth and EMT via the miR-7/Sp1 axis in lung adenocarcinoma.			hsa_circ_SETDB1	SETDB1	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"In LUAD, exosomal circSETDB1 is upregulated under hypoxia and in patient serum exosomes. It promotes proliferation, migration, invasion and EMT by sponging miR-7 to upregulate Sp1, enhancing tumor growth and metastasis."	0.8871
33615661	Journal of cellular and molecular medicine	2022	Circular RNA circEIF4G2 aggravates renal fibrosis in diabetic nephropathy by sponging miR-218.			mmu_circ_EIF4G2	EIF4G2	diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"circEIF4G2 is up-regulated in diabetic nephropathy models and promotes renal tubular epithelial cell fibrosis. It functions as a ceRNA by sponging miR-218, thereby relieving repression of SERBP1 and increasing fibrosis-related proteins such as TGF-beta1, Collagen I and Fibronectin."	0.5607
33615686	The Kaohsiung journal of medical sciences	2021	The depletion of Circ-PRKDC enhances autophagy and apoptosis in T-cell acute lymphoblastic leukemia via microRNA-653-5p/Reelin mediation of the PI3K/AKT/mTOR signaling pathway.		Circ_PRKDC 	hsa_circ_PRKDC	PRKDC	T-cell acute lymphoblastic leukemia 	MONDO:0004963	T-cell acute lymphoblastic leukemia	up-regulated	RT-qPCR	"Circ-PRKDC is up-regulated in T-ALL bone marrow samples and T-ALL cell lines. Functionally, Circ-PRKDC promotes proliferation and PI3K/AKT/mTOR pathway activation while suppressing autophagy and apoptosis by sponging miR-653-5p to upregulate RELN."	0.7032
33617480	Aging	2021	Circ_0000527 promotes osteosarcoma cell progression through modulating miR-646/ARL2 axis.	hsa_circ_0000527	circ_0000527			osteosarcoma	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ_0000527 is up-regulated in osteosarcoma cells and patient specimens. Functionally, its overexpression promotes proliferation and cell-cycle progression and increases secretion of inflammatory cytokines. Mechanistically, circ_0000527 acts as a miR-646 sponge to relieve repression of ARL2 (circ_0000527/miR-646/ARL2 axis)."	0.6996
33618745	Journal of experimental & clinical cancer research : CR	2021	CircAGAP1 promotes tumor progression by sponging miR-15-5p in clear cell renal cell carcinoma.	hsa_circ_0058792	circAGAP1 	hsa_circ_AGAP1	AGAP1	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR; Microarray	"circAGAP1 (hsa_circ_0058792), derived from AGAP1, is up-regulated in ccRCC and mainly localized in the cytoplasm. It promotes ccRCC proliferation/viability, migration and invasion and inhibits apoptosis by acting as a ceRNA that sponges miR-15a-5p, thereby increasing E2F3 expression and driving tumor progression in vitro and in a cell line-derived xenograft model."	0.8769
33621401	Journal of cellular and molecular medicine	2022	Circular RNA circ_0002137 regulated the progression of osteosarcoma through regulating miR-433-3p/ IGF1R axis.	hsa_circ_0002137	circ_0002137 			osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"hsa_circ_0002137 is up-regulated in osteosarcoma tissues and OS cell lines. Functionally, circ_0002137 knockdown inhibits proliferation, invasion and migration, induces G0/G1 arrest, and promotes apoptosis, and suppresses xenograft tumor growth. Mechanistically, circ_0002137 binds (sponges) miR-433-3p to regulate IGF1R expression, forming a circ_0002137/miR-433-3p/IGF1R axis in OS."	0.7418
33628035	OncoTargets and therapy	2021	Circular RNA circDNM3OS Functions as a miR-145-5p Sponge to Accelerate Cholangiocarcinoma Growth and Glutamine Metabolism by Upregulating MORC2.	hsa_circ_0005230	circDNM3OS	hsa_circ_DNM3OS	DNM3OS	Cholangiocarcinoma 	MONDO:0019087	cholangiocarcinoma	up-regulated	RT-qPCR	"circDNM3OS is up-regulated in cholangiocarcinoma tissues and cells and mainly localizes to the cytoplasm. It promotes tumor growth and malignant phenotypes (proliferation, migration/invasion) and enhances glutamine metabolism by sponging miR-145-5p to upregulate MORC2."	0.7637
33628056	Cancer management and research	2021	Circ_0006174 Accelerates Colorectal Cancer Progression Through Regulating miR-138-5p/MACC1 Axis.	hsa_circ_0006174	circ_0006174	hsa_circ_RAD23B	RAD23B	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0006174 is up-regulated in colorectal cancer tissues/cells and acts as an oncogenic circRNA. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-138-5p, thereby increasing MACC1 expression to promote proliferation, migration/invasion and tumor growth while inhibiting apoptosis; high circ_0006174 correlates with poorer overall survival."	0.8035
33629528	Journal of cellular and molecular medicine	2021	CircORC2 is involved in the pathogenesis of slow transit constipation via modulating the signalling of miR-19a and neurotensin/motilin.		circORC2 	hsa_circ_ORC2	ORC2	slow transit constipation 	MONDO:0002203	constipation disorder	down-regulated	RT-qPCR	"In STC patients, circORC2 is down-regulated in peripheral blood. circORC2 acts as a miR-19a sponge, relieving miR-19a-mediated repression of MLN and NST, thereby increasing motilin and neurotensin signaling that may benefit STC."	0.6102
33632213	Cancer cell international	2021	"CircMMP11 regulates proliferation, migration, invasion, and apoptosis of breast cancer cells through miR-625-5p/ZEB2 axis."	hsa_circ_0062558	CircMMP11	hsa_circ_MMP11	MMP11	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circMMP11 is up-regulated in breast cancer tissues and cell lines and functions as an oncogenic circRNA. It sponges miR-625-5p to de-repress ZEB2, thereby promoting proliferation, migration/invasion (with EMT marker changes) and inhibiting apoptosis, and its knockdown suppresses xenograft tumor growth."	0.705
33633191	Scientific reports	2021	CircSLC8A1 and circNFIX can be used as auxiliary diagnostic markers for sudden cardiac death caused by acute ischemic heart disease.		circSLC8A1	hsa_circ_SLC8A1	Slc8a1	acute myocardial infarction	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR	circSLC8A1 is up-regulated in acute ischemic damage and is elevated in myocardium from MI-related IHD SCD autopsy cases. It shows diagnostic utility (ROC performance) for postmortem MI and correlates positively with CK-MB levels in pericardial fluid.	0.6888
33633191	Scientific reports	2021	CircSLC8A1 and circNFIX can be used as auxiliary diagnostic markers for sudden cardiac death caused by acute ischemic heart disease.		circNFIX	hsa_circ_NFIX	NFIX	acute myocardial infarction	MONDO:0004781	acute myocardial infarction	down-regulated	RT-qPCR	"circNFIX is down-regulated in myocardium from IHD-related SCD autopsy cases (both MI and non-MI) and shows diagnostic value by ROC analysis. Its expression is negatively correlated with coronary artery stenosis grade, supporting its use as an auxiliary indicator of ischemic myocardial damage severity."	0.6888
33633466	Cancer management and research	2021	Circ_0020123 Increases ZFX Expression to Facilitate Non-Small Cell Lung Cancer Progression by Sponging miR-142-3p.	hsa_circ_0020123	Circ_0020123	hsa_circ_PDZD8	PDZD8	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0020123 is up-regulated in NSCLC tissues and cell lines and acts as an oncogenic circRNA. It promotes proliferation, migration/invasion and tumorigenesis while inhibiting apoptosis, mainly by sponging miR-142-3p to increase ZFX expression (miR-142-3p/ZFX axis)."	0.6831
33634097	Frontiers in cell and developmental biology	2020	Circular RNA_PDHX Promotes the Proliferation and Invasion of Prostate Cancer by Sponging MiR-378a-3p.	hsa_circ_0003768	circPDHX	hsa_circ_PDHX	PDHX	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; ISH; Microarray	"circPDHX (hsa_circ_0003768), derived from PDHX, is up-regulated in prostate cancer and mainly localized in the cytoplasm. It promotes PCa cell proliferation and invasion by sponging miR-378a-3p, thereby increasing IGF1R expression and activating IGF1R/PI3K/AKT signaling, and its high expression predicts poor overall survival."	0.8655
33637685	Cell death discovery	2021	Inhibition of intervertebral disc disease progression via the circPKNOX1-miR-370-3p-KIAA0355 axis.	hsa_circ_0061853	circPKNOX1	hsa_circ_PKNOX1	PKNOX1	intervertebral disc disease 	MONDO:0011385	intervertebral disk degenerative disorder	down-regulated	RT-qPCR; Microarray	"circPKNOX1 is down-regulated in degenerative nucleus pulposus tissues/cells and mainly localizes to the cytoplasm. It inhibits IVDD progression by sponging miR-370-3p, thereby restoring KIAA0355 expression and promoting ECM anabolism (e.g., collagen II, aggrecan, SOX9) while suppressing catabolic enzymes (e.g., ADAMTS4/5, MMP3/13)."	0.8244
33637694	Cell death & disease	2021	CircRAB11FIP1 promoted autophagy flux of ovarian cancer through DSC1 and miR-129.	hsa_circ_0005630	CircRAB11FIP1 	hsa_circ_RAB11FIP1	RAB11FIP1	epithelial ovarian cancer 	MONDO:0005140	ovarian carcinoma	up-regulated	RT-qPCR; RNA-seq	"circRAB11FIP1 is upregulated in epithelial ovarian cancer and promotes autophagic flux, enhancing proliferation, invasion/migration and in vivo metastasis. Mechanistically, it sponges miR-129 to increase ATG7/ATG14, binds DSC1 to enhance DSC1_ATG101 interaction, and binds FTO mRNA to elevate FTO and modulate m6A-dependent ATG5/ATG7 expression; it is proposed as a diagnostic/therapeutic biomarker for EOC."	0.7836
33637694	Cell death & disease	2021	CircRAB11FIP1 promoted autophagy flux of ovarian cancer through DSC1 and miR-129.	hsa_circ_0008561	circTCF20	hsa_circ_TCF20	TCF20	epithelial ovarian cancer 	MONDO:0005140	ovarian carcinoma	up-regulated	RT-qPCR	"circTCF20 was measured and found increased in EOC tissues/cells (and induced by Torin 1), but functional evidence in autophagy was not established in this paper (LC3-II showed no significant change after circTCF20 silencing)."	0.2586
33640021	"Journal of biological research (Thessalonike, Greece)"	2021	CircCTNNA1 acts as a ceRNA for miR-363-3p to facilitate the progression of colorectal cancer by promoting CXCL5 expression.		CircCTNNA1 	hsa_circ_CTNNA1	CTNNA1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circCTNNA1 is up-regulated in colorectal cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes CRC malignant phenotypes and tumor growth by acting as a ceRNA that sponges miR-363-3p, thereby increasing CXCL5 expression."	0.78
33641485	The Journal of international medical research	2021	Inhibitory role of circRNA_100395 in the proliferation and metastasis of prostate cancer cells.		circRNA_100395 			prostate cancer	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR	"circRNA_100395 is down-regulated in prostate cancer tissues and cell lines and acts as a tumor suppressor. Its overexpression inhibits proliferation and metastatic behaviors and suppresses EMT, at least partly through direct binding/inhibition of miR-1228."	0.6521
33642823	World journal of gastroenterology	2021	Circular RNA circVAPA promotes chemotherapy drug resistance in gastric cancer progression by regulating miR-125b-5p/STAT3 axis.		circVAPA	hsa_circ_VAPA	VAPA	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"CircVAPA is up-regulated in gastric cancer tissues and in cisplatin-resistant GC cells. It promotes proliferation, migration/invasion, tumor growth and cisplatin resistance while suppressing apoptosis, mainly by sponging miR-125b-5p and thereby increasing STAT3 signaling."	0.6287
33648498	Molecular cancer	2021	"CircWAC induces chemotherapeutic resistance in triple-negative breast cancer by targeting miR-142, upregulating WWP1 and activating the PI3K/AKT pathway."	hsa_circ_0007503	circWAC	hsa_circ_WAC	WAC	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; Microarray	"circWAC is up-regulated in TNBC and promotes paclitaxel chemoresistance. It primarily localizes to the cytoplasm and functions as a ceRNA sponge for miR-142, thereby de-repressing WWP1 and activating PI3K/AKT signaling; high circWAC correlates with worse overall survival."	0.8814
33648601	Stem cell research & therapy	2021	Exosomal hsa_circ_0006859 is a potential biomarker for postmenopausal osteoporosis and enhances adipogenic versus osteogenic differentiation in human bone marrow mesenchymal stem cells by sponging miR-431-5p.	hsa_circ_0006859				postmenopausal osteoporosis 	MONDO:0008159	postmenopausal osteoporosis	up-regulated	RT-qPCR; Microarray	"Exosomal hsa_circ_0006859 is upregulated in osteopenia/osteoporosis in postmenopausal women and shows diagnostic potential by ROC analysis. Functionally, it suppresses osteogenic differentiation and promotes adipogenic differentiation of hBMSCs by acting as a ceRNA that sponges miR-431-5p and upregulates ROCK1."	0.814
33649795	Oncology reports	2021	Circ_0000003 regulates glutamine metabolism and tumor progression of tongue squamous cell carcinoma via the miR_330_3p/GLS axis.	hsa_circ_0000003	circ_0000003			tongue squamous cell carcinoma 	MONDO:0000500	tongue squamous cell carcinoma	up-regulated	RT-qPCR	"hsa_circ_0000003 (circ_0000003) is up-regulated in TSCC tissues/cell lines and promotes malignant phenotypes (proliferation, migration, invasion). It acts as a ceRNA that sponges miR-330-3p, thereby relieving repression of GLS and enhancing glutamine catabolism (glutamine consumption, alpha-KG and ATP production), which contributes to tumor progression and poorer patient survival."	0.7938
33649815	International journal of molecular medicine	2021	circNRIP1 facilitates keloid progression via FXR1_mediated upregulation of miR_503_3p and miR_503_5p.		circNRIP1 	hsa_circ_NRIP1	NRIP1	keloids 	MONDO:0005348	keloid	up-regulated	RT-qPCR	"circNRIP1 is up-regulated in keloid tissues and keloid-derived fibroblasts and promotes fibroblast proliferation and extracellular matrix accumulation while inhibiting apoptosis. Mechanistically, circNRIP1 binds FXR1 and blocks Fbxo4-mediated ubiquitination/degradation of FXR1, which enhances pre-miR-503 maturation and increases miR-503-3p/miR-503-5p levels, facilitating keloid progression."	0.7977
33649821	International journal of oncology	2021	"Circ_0000511 accelerates the proliferation, migration and invasion, and restrains the apoptosis of breast cancer cells through the miR_326/TAZ axis."	hsa_circ_0000511	Circular RNA 0000511 	hsa_circ_RPPH1	RPPH1	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0000511 is up-regulated in breast cancer tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion) while inhibiting apoptosis. Mechanistically, it sponges miR-326 to relieve repression of TAZ, thereby increasing TAZ expression and tumor growth in vivo."	0.6971
33649850	Molecular medicine reports	2021	circ_0000212 promotes cell proliferation of colorectal cancer by sponging miR_491 and modulating FOXP4 expression.	hsa_circ_0000212	hsa-circ-0000212 	hsa_circ_SFMBT2	SFMBT2	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"In colorectal cancer, circ-0000212 is up-regulated and mainly localized in the cytoplasm. It promotes CRC cell proliferation by acting as a miR-491 sponge, thereby relieving miR-491-mediated repression of FOXP4 and increasing FOXP4 expression."	0.8191
33649864	Molecular medicine reports	2021	circRNA_0006896_miR1264_DNMT1 axis plays an important role in carotid plaque destabilization by regulating the behavior of endothelial cells in atherosclerosis.		circRNA-0006896 			atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR; Microarray	"This study identifies circRNA-0006896 as upregulated in serum exosomes from patients with unstable/vulnerable carotid plaques. Exosomal circRNA-0006896 is taken up by HUVECs and sponges miR-1264, increasing DNMT1 and downstream STAT3 phosphorylation while reducing SOCS3, thereby promoting endothelial proliferation and migration linked to plaque destabilization."	0.7519
33650644	International journal of oncology	2021	circUBAP2 regulates osteosarcoma progression via the miR_204_3p/HMGA2 axis.		circUBAP2 	hsa_circ_UBAP2	UBAP2	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circUBAP2 is up-regulated in osteosarcoma and functions as an oncogenic circRNA. It promotes proliferation, migration and invasion while inhibiting apoptosis, mainly by sponging miR-204-3p to derepress HMGA2 (circUBAP2/miR-204-3p/HMGA2 axis). High circUBAP2 expression is associated with worse overall survival and has diagnostic potential by ROC analysis."	0.819
33653372	Journal of orthopaedic surgery and research	2021	"Circ-AFF2/miR-650/CNP axis promotes proliferation, inflammatory response, migration, and invasion of rheumatoid arthritis synovial fibroblasts."	hsa_circ_0001947	circ-AFF2	hsa_circ_AFF2	AFF2	rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"circ-AFF2 (hsa_circ_0001947), derived from AFF2, is up-regulated in RA synovial tissues and primary RAFLSs and mainly localizes to the cytoplasm. Functionally, circ-AFF2 promotes RAFLS proliferation, inflammatory response, migration/invasion and EMT while suppressing apoptosis, by acting as a sponge for miR-650 to de-repress CNP (circ-AFF2/miR-650/CNP axis)."	0.7519
33654430	Cancer management and research	2021	Circular RNA circSPATA6 Inhibits the Progression of Oral Squamous Cell Carcinoma Cells by Regulating TRAF6 via miR-182.	hsa_circ_0008202	circSPATA6 	hsa_circ_SPATA6	SPATA6	Oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR	"circSPATA6 is down-regulated in OSCC serum and cell lines and acts as a tumor suppressor. It sponges miR-182 to upregulate TRAF6, thereby inhibiting migration/invasion, inducing cell-cycle arrest and apoptosis, and suppressing xenograft tumor growth; exosomal circSPATA6 also restrains OSCC cell progression."	0.8005
33656636	Cell biology and toxicology	2022	Circular RNA circGLIS3 promotes bladder cancer proliferation via the miR-1273f/SKP1/Cyclin D1 axis.	hsa_circ_0002874	circGLIS3	hsa_circ_GLIS3	GLIS3	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"circGLIS3 is up-regulated in bladder cancer tissues/cells and promotes proliferation, migration, invasion and xenograft growth. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-1273f to increase SKP1, which elevates Cyclin D1 and drives G0/G1 cell-cycle progression; it shows limited diagnostic potential (AUC ~0.66)."	0.8175
33657879	"Arteriosclerosis, thrombosis, and vascular biology"	2021	Circular RNA Calm4 Regulates Hypoxia-Induced Pulmonary Arterial Smooth Muscle Cells Pyroptosis via the Circ-Calm4/miR-124-3p/PDCD6 Axis.		circ-Calm4	mmu_circ_Calm4	Calm4	pulmonary hypertension 	MONDO:0005149	pulmonary hypertension	up-regulated	RT-qPCR; ISH	"In hypoxia-induced pulmonary hypertension models, circ-Calm4 is up-regulated in lung tissue and PASMCs and promotes PASMC pyroptosis. Mechanistically, it functions as a ceRNA sponge for miR-124-3p, thereby de-repressing Pdcd6/PDCD6 and driving pyroptosis-related phenotypes under hypoxia."	0.7011
33658002	"Molecular medicine (Cambridge, Mass.)"	2021	Knockdown of circROBO2 attenuates acute myocardial infarction through regulating the miR-1184/TRADD axis.		circROBO2	mmu_circ_ROBO2	ROBO2	acute myocardial infarction 	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR; ISH	"In a mouse MI model and hypoxia-injured primary cardiomyocytes, circROBO2 is up-regulated and aggravates myocardial injury by promoting cardiomyocyte apoptosis. Mechanistically, circROBO2 sponges miR-1184 to de-repress TRADD; circROBO2 knockdown increases miR-1184, decreases TRADD, and improves cardiac injury indicators and function in vivo."	0.73
33658057	Journal of orthopaedic surgery and research	2021	Knockdown of Circ_SLC39A8 protects against the progression of osteoarthritis by regulating miR-591/IRAK3 axis.	hsa_circ_0002782	circ_SLC39A8 	hsa_circ_SLC39A8	SLC39A8	osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circ_SLC39A8 is up-regulated in osteoarthritis cartilage. Functionally, circ_SLC39A8 promotes chondrocyte apoptosis, inflammation, and ECM degradation, while its knockdown is protective. Mechanistically, it acts as a miR-591 sponge to modulate IRAK3 (miR-591/IRAK3 axis)."	0.7129
33658855	Cancer management and research	2021	Exosomal circ_IFT80 Enhances Tumorigenesis and Suppresses Radiosensitivity in Colorectal Cancer by Regulating miR-296-5p/MSI1 Axis.		circ_IFT80 	hsa_circ_IFT80	IFT80	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_IFT80 is up-regulated in CRC patient serum-derived exosomes and CRC cells. It promotes CRC tumorigenesis and radioresistance by acting as a ceRNA sponge for miR-296-5p, thereby increasing MSI1 expression and enhancing proliferation/cell-cycle progression while suppressing apoptosis."	0.7181
33659023	Frontiers in genetics	2021	Identification of Differently Expressed mRNAs in Atherosclerosis Reveals CDK6 Is Regulated by circHIPK3/miR-637 Axis and Promotes Cell Growth in Human Vascular Smooth Muscle Cells.		circHIPK3		HIPK3	atherosclerosis	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"In human VSMCs relevant to atherosclerosis, circHIPK3 is up-regulated and mainly localized in the cytoplasm. circHIPK3 functions as a ceRNA to sponge miR-637, thereby relieving repression of CDK6 and promoting VSMC proliferation/cell-cycle progression while inhibiting apoptosis."	0.6579
33663506	Cancer cell international	2021	RNA sequencing reveals the expression profiles of circRNA and identifies a four-circRNA signature acts as a prognostic marker in esophageal squamous cell carcinoma.	hsa_circ_0008199		hsa_circ_ATXN10	ATXN10	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	unknown	RT-qPCR; RNA-seq	"hsa_circ_0008199 (ATXN10-derived) is one component of a four-circRNA signature that predicts overall survival in ESCC. In the model, it has a negative coefficient and is annotated as low expression with poor prognosis, implying higher expression contributes to a better predicted outcome."	0.7277
33663506	Cancer cell international	2021	RNA sequencing reveals the expression profiles of circRNA and identifies a four-circRNA signature acts as a prognostic marker in esophageal squamous cell carcinoma.	hsa_circ_0007541		hsa_circ_USP13	USP13	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	unknown	RT-qPCR; RNA-seq	hsa_circ_0007541 (USP13-derived) is a component of the four-circRNA prognostic signature for ESCC overall survival. It is annotated as high expression with poor prognosis and contributes positively to the model risk score.	0.7277
33663506	Cancer cell international	2021	RNA sequencing reveals the expression profiles of circRNA and identifies a four-circRNA signature acts as a prognostic marker in esophageal squamous cell carcinoma.	hsa_circ_0000005		hsa_circ_CDK11A	CDK11A	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	unknown	RT-qPCR; RNA-seq	hsa_circ_0000005 (CDK11A-derived) is a component of the four-circRNA prognostic signature for ESCC overall survival. It is annotated as high expression with poor prognosis and contributes positively to the model risk score.	0.7277
33663506	Cancer cell international	2021	RNA sequencing reveals the expression profiles of circRNA and identifies a four-circRNA signature acts as a prognostic marker in esophageal squamous cell carcinoma.	hsa_circ_0077536		hsa_circ_ATG5	ATG5	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	unknown	RT-qPCR; RNA-seq	hsa_circ_0077536 (ATG5-derived) is a component of the four-circRNA prognostic signature for ESCC overall survival. It is annotated as high expression with poor prognosis and contributes positively to the model risk score.	0.7277
33663510	Cancer cell international	2021	Circular RNA circCSPP1 knockdown attenuates doxorubicin resistance and suppresses tumor progression of colorectal cancer via miR-944/FZD7 axis.	hsa_circ_0001806	circCSPP1	hsa_circ_CSPP1	CSPP1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circCSPP1 is up-regulated in DOX-resistant colorectal cancer tissues and cell models. Silencing circCSPP1 increases doxorubicin sensitivity and suppresses malignant phenotypes (proliferation, migration, invasion) while promoting apoptosis, partly through a ceRNA mechanism involving miR-944 and downstream target FZD7, and it inhibits xenograft tumor growth in vivo."	0.7087
33664565	"Drug design, development and therapy"	2021	Aloperine Inhibits Proliferation and Promotes Apoptosis in Colorectal Cancer Cells by Regulating the circNSUN2/miR-296-5p/STAT3 Pathway.		circNSUN2	hsa_circ_NSUN2	NSUN2	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"In CRC cell lines, Aloperine suppresses circNSUN2, and circNSUN2 promotes malignant phenotypes by sponging miR-296-5p to support STAT3 signaling. Overexpression of circNSUN2 partially rescues Aloperine-induced inhibition of proliferation and promotion of apoptosis, confirming a circNSUN2/miR-296-5p/STAT3 regulatory axis."	0.6536
33664803	Oncology letters	2021	Upregulated hsa_circ_0000129 expression promotes proliferation and migration of breast cancer cells.	hsa_circ_0000129				breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"hsa_circ_0000129 is upregulated in breast cancer tissues and cell lines and promotes malignant phenotypes (proliferation, migration, colony formation). Mechanistically, it positively regulates EZH2 expression in breast cancer cells and is associated with lymph node metastasis and higher TNM stage, suggesting prognostic potential."	0.5732
33664993	Molecular therapy. Nucleic acids	2021	circCAMSAP1 promotes osteosarcoma progression and metastasis by sponging miR-145-5p and regulating FLI1 expression.	hsa_circ_0004338	circCAMSAP1 	hsa_circ_CAMSAP1	CAMSAP1	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circCAMSAP1 (hsa_circ_0004338) is up-regulated in osteosarcoma tissues/cell lines and mainly localized in the cytoplasm. It promotes osteosarcoma proliferation, migration, invasion and tumor growth by sponging miR-145-5p to derepress FLI1 (with downstream effects including increased c-Myc and decreased IGFBP3)."	0.8233
33674567	Cell death & disease	2021	Hsa_circ_0110757 upregulates ITGA1 to facilitate temozolomide resistance in glioma by suppressing hsa-miR-1298-5p.	hsa_circ_0110757		hsa_circ_Mcl-1	Mcl-1	glioma; temozolomide resistance 	MONDO:0021042	glioma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0110757 is up-regulated in TMZ-resistant glioma tissues and cells, promoting TMZ resistance and invasion while inhibiting apoptosis. Mechanistically, it acts as a miRNA sponge for hsa-miR-1298-5p to de-repress ITGA1, which activates PI3K/AKT signaling (with increased Bcl-2), reducing TMZ-induced apoptosis."	0.8539
33675150	Journal of cellular and molecular medicine	2021	Circ-LAMP1 contributes to the growth and metastasis of cholangiocarcinoma via miR-556-5p and miR-567 mediated YY1 activation.	hsa_circ_0030998		hsa_circ_LAMP1	LAMP1	cholangiocarcinoma 	MONDO:0019087	cholangiocarcinoma	up-regulated	RT-qPCR; Microarray	"circ-LAMP1 is up-regulated in cholangiocarcinoma and predominantly localized in the cytoplasm. It promotes CCA proliferation, invasion and metastasis and inhibits apoptosis by acting as a ceRNA that sponges miR-556-5p and miR-567, thereby up-regulating YY1. High circ-LAMP1 expression is associated with recurrence and poor survival in CCA patients."	0.8737
33675175	Orthopaedic surgery	2021	CircRNA circ-IQGAP1 Knockdown Alleviates Interleukin-1beta-Induced Osteoarthritis Progression via Targeting miR-671-5p/TCF4.			hsa_circ_IQGAP1	IQGAP1	osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circ-IQGAP1 is up-regulated in OA cartilage and in IL-1beta-treated CHON-001 cells. It promotes OA-like chondrocyte injury by sponging miR-671-5p, thereby increasing TCF4 and enhancing apoptosis, inflammatory cytokine secretion, and extracellular matrix degradation; circ-IQGAP1 knockdown is protective."	0.6811
33679417	Frontiers in pharmacology	2021	"CircMAP3K11 Contributes to Proliferation, Apoptosis and Migration of Human Periodontal Ligament Stem Cells in Inflammatory Microenvironment by Regulating TLR4 via miR-511 Sponging."			hsa_circ_MAP3K11	MAP3K11	periodontitis 	MONDO:0005076	periodontitis	up-regulated	RT-qPCR	"circMAP3K11 is up-regulated in periodontitis periodontal ligament tissue. It promotes hPDLSC proliferation and migration and inhibits apoptosis by sponging miR-511-3p, thereby increasing TLR4 expression (circMAP3K11/miR-511-3p/TLR4 axis)."	0.6545
33679420	Frontiers in pharmacology	2021	"Identification of Plasma hsa_circ_0005397 and Combined With Serum AFP, AFP-L3 as Potential Biomarkers for Hepatocellular Carcinoma."	hsa_circ_0005397		hsa_circ_RHOT1	RHOT1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"Plasma hsa_circ_0005397 is up-regulated in HCC patients and is detectable and stable in plasma. It shows diagnostic value alone and higher sensitivity when combined with AFP and AFP-L3, and its high level is associated with advanced disease features and poorer overall survival; postoperative dynamics may indicate recurrence/metastasis."	0.6888
33679870	Frontiers in genetics	2020	Comprehensive circRNA Expression Profile and Construction of circRNAs-Related ceRNA Network in a Mouse Model of Autism.		novel_circ_015779			autism 	MONDO:0005260	autism	up-regulated	RT-qPCR; RNA-seq	"novel_circ_015779 is up-regulated in brain tissues from a valproic acid-induced mouse model of autism, supported by RNA-seq and RT-qPCR."	0.3213
33679870	Frontiers in genetics	2020	Comprehensive circRNA Expression Profile and Construction of circRNAs-Related ceRNA Network in a Mouse Model of Autism.		novel_circ_035247			autism 	MONDO:0005260	autism	up-regulated	RT-qPCR; RNA-seq	"novel_circ_035247 is up-regulated in brain tissues from a valproic acid-induced mouse model of autism, supported by RNA-seq and RT-qPCR."	0.3213
33680929	Frontiers in oncology	2020	Knockdown of circRNA circ_0087378 Represses the Tumorigenesis and Progression of Esophageal Squamous Cell Carcinoma Through Modulating the miR-140-3p/E2F3 Axis.	hsa_circ_0087378				esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ_0087378 is up-regulated in ESCC and mainly localized in the cytoplasm. It promotes ESCC malignant phenotypes and xenograft growth by acting as a ceRNA that sponges miR-140-3p, thereby derepressing E2F3; high circ_0087378 is associated with worse overall survival."	0.8399
33680975	Frontiers in oncology	2021	CircHIPK3 Promotes the Tumorigenesis and Development of Gastric Cancer Through miR-637/AKT1 Pathway.		circHIPK3 	hsa_circ_HIPK3		gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in gastric cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes gastric cancer cell viability/proliferation, migration, and invasion by functioning as a ceRNA that sponges miR-637 and thereby increases AKT1 expression."	0.6676
33681183	Frontiers in cell and developmental biology	2020	Circular RNA POSTN Promotes Myocardial Infarction-Induced Myocardial Injury and Cardiac Remodeling by Regulating miR-96-5p/BNIP3 Axis.			hsa_circ_POSTN	POSTN	myocardial infarction 	MONDO:0005068	myocardial infarction	up-regulated	RT-qPCR	"circPostn is up-regulated in MI (patient plasma and MI mouse hearts) and in H/R-treated human cardiomyocytes. It aggravates MI-related myocardial injury and cardiac remodeling by sponging miR-96-5p to de-repress BNIP3, promoting cardiomyocyte injury/apoptosis and remodeling markers."	0.6536
33681183	Frontiers in cell and developmental biology	2020	Circular RNA POSTN Promotes Myocardial Infarction-Induced Myocardial Injury and Cardiac Remodeling by Regulating miR-96-5p/BNIP3 Axis.			mmu_circ_Postn	Postn	myocardial infarction 	MONDO:0005068	myocardial infarction	up-regulated	RT-qPCR	"circPostn is up-regulated in MI (patient plasma and MI mouse hearts) and in H/R-treated human cardiomyocytes. It aggravates MI-related myocardial injury and cardiac remodeling by sponging miR-96-5p to de-repress BNIP3, promoting cardiomyocyte injury/apoptosis and remodeling markers."	0.6536
33685351	Bioengineered	2021	Circular RNA circ_0000467 regulates colorectal cancer development via miR-382-5p/EN2 axis.	hsa_circ_0000467				colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circ_0000467 is up-regulated in colorectal cancer tissues and cell lines and is mainly localized in the cytoplasm. It promotes CRC cell proliferation, migration, invasion and EMT by sponging miR-382-5p and thereby increasing EN2 expression."	0.7589
33685441	Cancer cell international	2021	CircTP63 promotes hepatocellular carcinoma progression by sponging miR-155-5p and upregulating ZBTB18.		circTP63	hsa_circ_TP63	TP63	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circTP63 is up-regulated in HCC and functions as an oncogenic circRNA. It promotes proliferation/migration/invasion and inhibits apoptosis by sponging miR-155-5p, thereby increasing ZBTB18 expression (circTP63/miR-155-5p/ZBTB18 axis). High circTP63 expression is associated with advanced clinicopathological features and poorer overall survival."	0.8174
33685455	World journal of surgical oncology	2021	Circ_DOCK1 regulates USP11 through miR-132-3p to control colorectal cancer progression.	hsa_circ_0020397	circ_DOCK1	hsa_circ_DOCK1	DOCK1	colorectal cancer	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_DOCK1 (hsa_circ_0020397) is up-regulated in colorectal cancer and mainly localized in the cytoplasm. It promotes proliferation and metastasis and inhibits apoptosis by sponging miR-132-3p to increase USP11 expression, and its knockdown suppresses xenograft tumor growth."	0.8326
33686957	Aging	2021	Circular RNA RHOT1 promotes progression and inhibits ferroptosis via mir-106a-5p/STAT3 axis in breast cancer.		circRHOT1	hsa_circ_RHOT1	RHOT1	breast cancer	MONDO:0007254	breast cancer	unknown	RT-qPCR	"circRHOT1 promotes malignant progression of breast cancer cells (proliferation, invasion/migration) and suppresses apoptosis and ferroptosis. Mechanistically, it functions as a ceRNA by sponging miR-106a-5p to upregulate STAT3, and its knockdown suppresses tumor growth in a cell line-derived xenograft model."	0.5637
33688484	International journal of molecular and cellular medicine	2020	The Expression Pattern and Clinicopathological Importance of Hsa_circ_000425 in Colorectal Cancer.	hsa_circ_0001563	hsa_circ_000425 	hsa_circ_HNRPNPH1	HNRPNPH1	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"hsa_circ_000425 (hsa_circ_0001563) is significantly down-regulated in colorectal cancer tissues and several CRC cell lines. Lower expression is associated with poor differentiation and lymphatic metastasis, and it shows diagnostic potential (ROC AUC 0.839)."	0.6238
33692802	Frontiers in immunology	2021	Circ_0088194 Promotes the Invasion and Migration of Rheumatoid Arthritis Fibroblast-Like Synoviocytes via the miR-766-3p/MMP2 Axis.	hsa_circ_0088194	Circ_0088194	hsa_circ_TNC	TNC	rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; Microarray	Circ_0088194 is up-regulated in RA-FLSs and correlates with DAS28. It promotes RA-FLS migration and invasion by sponging miR-766-3p to upregulate MMP2.	0.8271
33704915	Thoracic cancer	2021	Identification of differentially expressed circular RNAs associated with thymoma.	hsa_circ_0001173		hsa_circ_VAPB	VAPB	thymoma	MONDO:0006456	thymoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0001173 is up-regulated in thymoma tissues and is implicated (via predicted circRNA_miRNA_mRNA networks) in immune-related pathways such as MAPK/TNF signaling and other enriched processes. Its mechanistic miRNA targets were predicted but not experimentally validated in this study.	0.585
33704915	Thoracic cancer	2021	Identification of differentially expressed circular RNAs associated with thymoma.	hsa_circ_0007291		hsa_circ_SCAP	SCAP	thymoma	MONDO:0006456	thymoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0007291 is up-regulated in thymoma and was used to build predicted circRNA_miRNA_mRNA networks linked to immune-related pathways (e.g., MAPK/TNF). The study also analyzed its host gene SCAP in Kaplan_Meier plots, suggesting clinical relevance at the parental-gene level."	0.6556
33704915	Thoracic cancer	2021	Identification of differentially expressed circular RNAs associated with thymoma.	hsa_circ_0003550		hsa_circ_WDR1	WDR1	thymoma	MONDO:0006456	thymoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0003550 is up-regulated in thymoma tissues and is linked by enrichment/network analyses to immune-related signaling and processes (e.g., MAPK/TNF-related inflammation) through predicted ceRNA networks. No specific miRNA partners were experimentally validated."	0.585
33704915	Thoracic cancer	2021	Identification of differentially expressed circular RNAs associated with thymoma.	hsa_circ_0001947		hsa_circ_AFF2	AFF2	thymoma	MONDO:0006456	thymoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001947 is up-regulated in thymoma and is linked to immune-related signaling by circRNA_miRNA_mRNA network and KEGG analyses. The paper further suggests a possible relationship with its host gene AFF2 and reports parental-gene survival associations, but miRNA interactions were not experimentally validated."	0.6556
33704916	Brain and behavior	2021	IGF2R circular RNA hsa_circ_0131235 expression in the middle temporal cortex is associated with AD pathology.	hsa_circ_0131235		hsa_circ_IGF2R	IGF2R	Alzheimer disease 	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0131235 (IGF2R circRNA) is up-regulated in the middle temporal cortex of individuals with high AD pathology compared with low pathology. The study supports its potential use as a marker of AD pathology burden, while mechanism and localization were not determined."	0.585
33707417	Cell death & disease	2021	Cancer-associated fibroblast-derived CXCL11 modulates hepatocellular carcinoma cell migration and tumor metastasis through the circUBAP2/miR-4756/IFIT1/3 axis.		circUBAP2	hsa_circ_UBAP2	UBAP2	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"In HCC, CXCL11 from CAFs induces upregulation of circUBAP2. circUBAP2 promotes HCC cell migration and metastasis by sponging miR-4756, thereby relieving miR-4756 repression of IFIT1/IFIT3 and increasing IL-1beta/IL-17-associated inflammatory output."	0.7373
33708621	Frontiers in oncology	2021	Analysis and Validation of circRNA-miRNA Network in Regulating m6A RNA Methylation Modulators Reveals CircMAP2K4/miR-139-5p/YTHDF1 Axis Involving the Proliferation of Hepatocellular Carcinoma.	hsa_circ_0007456	circMAP2K4 	hsa_circ_MAP2K4	MAP2K4	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	unknown	RT-qPCR	"circMAP2K4 (hsa_circ_0007456) promotes proliferation of hepatocellular carcinoma cells. Mechanistically, it sponges hsa-miR-139-5p, leading to increased YTHDF1 expression and partial reversal of miR-139-5p-mediated growth inhibition."	0.6575
33713570	Journal of cellular and molecular medicine	2021	Circular RNA circANAPC2 mediates the impairment of endochondral ossification by miR-874-3p/SMAD3 signalling pathway in idiopathic short stature.	hsa_circ_0003129	circANAPC2 	hsa_circ_ANAPC2	ANAPC2	idiopathic short stature 	MONDO:1010112	isolated short stature	up-regulated	RT-qPCR; Microarray	"circANAPC2 is up-regulated in idiopathic short stature and suppresses chondrocyte proliferation (G1 arrest), hypertrophy, and endochondral ossification. Mechanistically, it sponges miR-874-3p, leading to increased SMAD3 (and downstream effects such as IHH reduction), forming a circANAPC2/miR-874-3p/SMAD3 axis."	0.7489
33714195	Aging	2021	"Determining the influence of high glucose on exosomal lncRNAs, mRNAs, circRNAs and miRNAs derived from human renal tubular epithelial cells."	hsa_circ_0028717	circRNA_164	hsa_circ_GCN1	GCN1	diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	down-regulated	RNA-seq	"Exosomal circRNA_164 (GCN1-derived; circBase IDs hsa_circ_0028717/hsa_circ_0000448) is down-regulated in exosomes from high-glucose_treated HK-2 cells versus controls, suggesting potential involvement in diabetic nephropathy-related changes. Its functional role is not experimentally validated and is only explored via RNA-seq and predicted ceRNA/network analyses."	0.1768
33714195	Aging	2021	"Determining the influence of high glucose on exosomal lncRNAs, mRNAs, circRNAs and miRNAs derived from human renal tubular epithelial cells."	hsa_circ_0000448	circRNA_164	hsa_circ_GCN1	GCN1	diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	down-regulated	RNA-seq	"Exosomal circRNA_164 (GCN1-derived; circBase IDs hsa_circ_0028717/hsa_circ_0000448) is down-regulated in exosomes from high-glucose_treated HK-2 cells versus controls, suggesting potential involvement in diabetic nephropathy-related changes. Its functional role is not experimentally validated and is only explored via RNA-seq and predicted ceRNA/network analyses."	0.1768
33714195	Aging	2021	"Determining the influence of high glucose on exosomal lncRNAs, mRNAs, circRNAs and miRNAs derived from human renal tubular epithelial cells."	hsa_circ_0061273	circRNA_225	hsa_circ_NRIP1	NRIP1	diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	down-regulated	RNA-seq	Exosomal circRNA_225 (NRIP1-derived; circBase IDs hsa_circ_0061273/hsa_circ_0141673/hsa_circ_0004771) is down-regulated in exosomes from high-glucose_treated HK-2 cells versus controls. The study only provides RNA-seq profiling and predicted network/interaction analyses without experimental functional validation.	0.1768
33714195	Aging	2021	"Determining the influence of high glucose on exosomal lncRNAs, mRNAs, circRNAs and miRNAs derived from human renal tubular epithelial cells."	hsa_circ_0141673	circRNA_225	hsa_circ_NRIP1	NRIP1	diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	down-regulated	RNA-seq	Exosomal circRNA_225 (NRIP1-derived; circBase IDs hsa_circ_0061273/hsa_circ_0141673/hsa_circ_0004771) is down-regulated in exosomes from high-glucose_treated HK-2 cells versus controls. The study only provides RNA-seq profiling and predicted network/interaction analyses without experimental functional validation.	0.1768
33714195	Aging	2021	"Determining the influence of high glucose on exosomal lncRNAs, mRNAs, circRNAs and miRNAs derived from human renal tubular epithelial cells."	hsa_circ_0004771	circRNA_225	hsa_circ_NRIP1	NRIP1	diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	down-regulated	RNA-seq	Exosomal circRNA_225 (NRIP1-derived; circBase IDs hsa_circ_0061273/hsa_circ_0141673/hsa_circ_0004771) is down-regulated in exosomes from high-glucose_treated HK-2 cells versus controls. The study only provides RNA-seq profiling and predicted network/interaction analyses without experimental functional validation.	0.1768
33714195	Aging	2021	"Determining the influence of high glucose on exosomal lncRNAs, mRNAs, circRNAs and miRNAs derived from human renal tubular epithelial cells."	hsa_circ_0068682	circRNA_57	hsa_circ_DLG1	DLG1	diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	down-regulated	RNA-seq	"Exosomal circRNA_57 (DLG1-derived; circBase IDs hsa_circ_0068682/hsa_circ_0008583) is down-regulated in exosomes from high-glucose_treated HK-2 cells versus controls. The study reports RNA-seq-based differential expression and predicted ceRNA/network analyses, but no direct functional experiments validating its role in diabetic nephropathy."	0.1768
33714195	Aging	2021	"Determining the influence of high glucose on exosomal lncRNAs, mRNAs, circRNAs and miRNAs derived from human renal tubular epithelial cells."	hsa_circ_0008583	circRNA_57	hsa_circ_DLG1	DLG1	diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	down-regulated	RNA-seq	"Exosomal circRNA_57 (DLG1-derived; circBase IDs hsa_circ_0068682/hsa_circ_0008583) is down-regulated in exosomes from high-glucose_treated HK-2 cells versus controls. The study reports RNA-seq-based differential expression and predicted ceRNA/network analyses, but no direct functional experiments validating its role in diabetic nephropathy."	0.1768
33714261	Bosnian journal of basic medical sciences	2021	"Circ-RNF13, as an oncogene, regulates malignant progression of HBV-associated hepatocellular carcinoma cells and HBV infection through ceRNA pathway of circ-RNF13/miR-424-5p/TGIF2."	hsa_circ_0067717	circ-RNF13 	hsa_circ_RNF13	RNF13	HBV-associated hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ-RNF13 is up-regulated in HBV-associated HCC tissues and HBV-expressing HCC cells, mainly localized in the cytoplasm. It promotes malignant phenotypes and HBV replication by sponging miR-424-5p and positively regulating TGIF2 in a ceRNA axis."	0.7421
33715625	World journal of surgical oncology	2021	Circ-KIAA0907 inhibits the progression of oral squamous cell carcinoma by regulating the miR-96-5p/UNC13C axis.			hsa_circ_KIAA0907	KIAA0907	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR	"Circ-KIAA0907 is down-regulated in OSCC tissues and cell lines and mainly localizes to the cytoplasm. Functionally, its overexpression suppresses migration, invasion, glycolysis, and tumor growth while promoting apoptosis and radiosensitivity. Mechanistically, it acts as a ceRNA that sponges miR-96-5p to upregulate UNC13C."	0.7977
33718243	Frontiers in oncology	2021	Increased Expression of hsa_circ_0002111 and Its Clinical Significance in Papillary Thyroid Cancer.	hsa_circ_0002111		hsa_circ_PSD3	PSD3	papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0002111 is up-regulated in papillary thyroid cancer tissues and PTC cell lines. Functional knockdown experiments indicate it promotes PTC cell proliferation, migration, and invasion, and it shows potential diagnostic value (AUC 0.833), though its molecular mechanism was not investigated."	0.6758
33718350	Frontiers in cell and developmental biology	2021	Differential CircRNA Expression Signatures May Serve as Potential Novel Biomarkers in Prostate Cancer.	hsa_circ_0064644		hsa_circ_RBMS3	RBMS3	prostate cancer 	MONDO:0008315	prostate cancer	down-regulated	Microarray	"hsa_circ_0064644 is down-regulated in malignant versus benign/normal prostate cell lines. Bioinformatic analyses link it to the host gene RBMS3 and predict interaction with miR-15a, suggesting a potential miRNA-related regulatory role in prostate cancer."	0.1768
33718350	Frontiers in cell and developmental biology	2021	Differential CircRNA Expression Signatures May Serve as Potential Novel Biomarkers in Prostate Cancer.	hsa_circ_0060539		hsa_circ_SDC4	SDC4	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	Microarray	"hsa_circ_0060539 is highly up-regulated in malignant versus benign/normal prostate cell lines. It is bioinformatically linked to the host gene SDC4, but no downstream miRNA targets or functional assays were reported."	0.1768
33718350	Frontiers in cell and developmental biology	2021	Differential CircRNA Expression Signatures May Serve as Potential Novel Biomarkers in Prostate Cancer.	hsa_circ_0021652		hsa_circ_CAPRIN1	CAPRIN1	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	Microarray	"hsa_circ_0021652 (CAPRIN1-derived) is among the top up-regulated circRNAs in androgen-dependent versus androgen-independent prostate cancer cell lines, highlighting it as part of an androgen-dependency expression signature. The study did not experimentally validate its mechanism or clinical relevance."	0.1768
33718350	Frontiers in cell and developmental biology	2021	Differential CircRNA Expression Signatures May Serve as Potential Novel Biomarkers in Prostate Cancer.	hsa_circ_0000288		hsa_circ_CAPRIN1	CAPRIN1	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	Microarray	"hsa_circ_0000288 (CAPRIN1-derived) is among the top up-regulated circRNAs in androgen-dependent versus androgen-independent prostate cancer cell lines, suggesting it contributes to an androgen-dependency-associated circRNA signature. No experimental validation of its mechanism was reported."	0.1768
33718350	Frontiers in cell and developmental biology	2021	Differential CircRNA Expression Signatures May Serve as Potential Novel Biomarkers in Prostate Cancer.	hsa_circ_0021647		hsa_circ_CAPRIN1	CAPRIN1	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	Microarray	"hsa_circ_0021647 (CAPRIN1-derived) is among the top up-regulated circRNAs in androgen-dependent versus androgen-independent prostate cancer cell lines, consistent with an androgen-dependency-related circRNA signature. The study provides no experimental functional validation for this circRNA."	0.1768
33718350	Frontiers in cell and developmental biology	2021	Differential CircRNA Expression Signatures May Serve as Potential Novel Biomarkers in Prostate Cancer.	hsa_circ_0000367		hsa_circ_SIAE	SIAE	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	Microarray	hsa_circ_0000367 (also written as hsa_circ_0000361 in the text) is reported as up-regulated between androgen-dependent and androgen-independent prostate cancer cell lines and is associated with the host gene SIAE. The study does not provide mechanistic or functional validation beyond microarray/bioinformatic annotation.	0.1768
33718350	Frontiers in cell and developmental biology	2021	Differential CircRNA Expression Signatures May Serve as Potential Novel Biomarkers in Prostate Cancer.	hsa_circ_0000825		hsa_circ_MTCL1	MTCL1	prostate cancer 	MONDO:0008315	prostate cancer	down-regulated	Microarray	hsa_circ_0000825 is reported as the most strongly down-regulated circRNA (by fold change) between androgen-dependent and androgen-independent prostate cancer cell lines and is associated with the host gene MTCL1. The study provides no direct functional or mechanistic validation for this circRNA.	0.1768
33718387	Frontiers in cell and developmental biology	2021	Circular RNA circ_0057558 Controls Prostate Cancer Cell Proliferation Through Regulating miR-206/USP33/c-Myc Axis.	hsa_circ_0057558		hsa_circ_SLC39A10	SLC39A10	prostate cancer	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circ_0057558 is up-regulated in prostate cancer and acts oncogenically by promoting proliferation and cell-cycle progression. Mechanistically, it sponges miR-206 to upregulate USP33, which deubiquitinates and stabilizes c-Myc, and it reduces sensitivity to docetaxel."	0.805
33719338	Frontiers in genetics	2021	Construction of circRNA-Based ceRNA Network to Reveal the Role of circRNAs in the Progression and Prognosis of Hepatocellular Carcinoma.	hsa_circ_0077210				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	dysregulated	RT-qPCR; Microarray	"This study identified hsa_circ_0077210 as an upstream regulator in an HCC ceRNA axis, potentially modulating hsa-miR-92b-3p and downstream targets CPEB3 and ACADL. The axis is proposed to inhibit HCC occurrence and progression and was supported by differential expression in clinical HCC tissues."	0.4032
33722210	BMC cancer	2021	The characteristics of circRNA as competing endogenous RNA in pathogenesis of acute myeloid leukemia.	hsa_circ_0000205				acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	down-regulated	Microarray	hsa_circ_0000205 was identified as a co-downregulated circRNA in AML bone marrow samples from two GEO circRNA microarray datasets and was included among DEcircRNAs used to build the AML ceRNA network.	0.1768
33722210	BMC cancer	2021	The characteristics of circRNA as competing endogenous RNA in pathogenesis of acute myeloid leukemia.	hsa_circ_0074371				acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	down-regulated	Microarray	"hsa_circ_0074371 is down-regulated in AML and was highlighted as a key circRNA in the circRNA_miRNA_hub gene subnetwork, predicted to regulate SIRPA by sponging hsa-miR-145-5p."	0.1768
33722210	BMC cancer	2021	The characteristics of circRNA as competing endogenous RNA in pathogenesis of acute myeloid leukemia.	hsa_circ_0001910				acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	down-regulated	Microarray	"hsa_circ_0001910 was detected as down-regulated in AML and included as one of the DEcircRNAs contributing to the constructed AML ceRNA network, but no specific miRNA/mRNA regulatory module was detailed for it."	0.1768
33722210	BMC cancer	2021	The characteristics of circRNA as competing endogenous RNA in pathogenesis of acute myeloid leukemia.	hsa_circ_0029410				acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	down-regulated	Microarray	"hsa_circ_0029410 was identified as a co-downregulated circRNA in AML from intersected GEO microarray datasets and was included in the AML ceRNA network construction, without a specific highlighted regulatory module in the hub subnetwork."	0.1768
33722210	BMC cancer	2021	The characteristics of circRNA as competing endogenous RNA in pathogenesis of acute myeloid leukemia.	hsa_circ_0012152				acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	Microarray	"hsa_circ_0012152 was the only co-upregulated circRNA identified across two AML circRNA microarray datasets and was included in the study¡¯s AML ceRNA network, but no specific downstream miRNA/mRNA module was highlighted for it."	0.1768
33722210	BMC cancer	2021	The characteristics of circRNA as competing endogenous RNA in pathogenesis of acute myeloid leukemia.	hsa_circ_0029407				acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	down-regulated	Microarray	"hsa_circ_0029407 is down-regulated in AML and was identified as a key circRNA in the circRNA_miRNA_hub gene subnetwork, predicted to regulate LDLR via hsa-miR-19b-3p."	0.1768
33722210	BMC cancer	2021	The characteristics of circRNA as competing endogenous RNA in pathogenesis of acute myeloid leukemia.	hsa_circ_0000994				acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	down-regulated	Microarray	"hsa_circ_0000994 is down-regulated in AML and was identified as a key circRNA in the AML circRNA_miRNA_hub gene subnetwork, predicted to act via hsa-miR-27b-3p to regulate CD28/HGF and via hsa-miR-495-3p to regulate HGF/PTPRJ."	0.1768
33722210	BMC cancer	2021	The characteristics of circRNA as competing endogenous RNA in pathogenesis of acute myeloid leukemia.	hsa_circ_0000660				acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	down-regulated	Microarray	"hsa_circ_0000660 was identified as down-regulated in AML and included among the DEcircRNAs in the AML ceRNA network, but no specific predicted miRNA/mRNA axis was highlighted for it."	0.1768
33722210	BMC cancer	2021	The characteristics of circRNA as competing endogenous RNA in pathogenesis of acute myeloid leukemia.	hsa_circ_0001394				acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	down-regulated	Microarray	"hsa_circ_0001394 is down-regulated in AML and was identified as a key circRNA in the AML circRNA_miRNA_hub gene subnetwork, predicted to regulate FCGR3A via hsa-miR-370-3p."	0.1768
33722210	BMC cancer	2021	The characteristics of circRNA as competing endogenous RNA in pathogenesis of acute myeloid leukemia.	hsa_circ_0007609				acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	down-regulated	Microarray	"hsa_circ_0007609 was found down-regulated in AML and included as a component of the constructed AML ceRNA network, but no specific miRNA/mRNA interactions were emphasized for it."	0.1768
33722210	BMC cancer	2021	The characteristics of circRNA as competing endogenous RNA in pathogenesis of acute myeloid leukemia.	hsa_circ_0008934				acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	down-regulated	Microarray	"hsa_circ_0008934 was identified as down-regulated in AML from GEO microarray datasets and included in the AML ceRNA network, but no specific AML-related ceRNA axis was detailed for it in the results."	0.1768
33722210	BMC cancer	2021	The characteristics of circRNA as competing endogenous RNA in pathogenesis of acute myeloid leukemia.	hsa_circ_0071375				acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	down-regulated	Microarray	"hsa_circ_0071375 was identified as down-regulated in AML and included as part of the AML ceRNA network, but no specific regulatory module or clinical association was provided for it."	0.1768
33723214	Cell death & disease	2021	CircRNA circ_0124554 blocked the ubiquitination of AKT promoting the skip lymphovascular invasion on hepatic metastasis in colorectal cancer.	hsa_circ_0124554	circ_0124554 	hsa_circ_FOXP1	FOXP1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Northern Blot; ISH; Microarray	"In lymph node-negative CRC with synchronous liver metastasis (LNLM1), hsa_circ_0124554 is up-regulated and promotes invasion/migration and in vivo metastasis. Mechanistically, it directly binds AKT, inhibits AKT ubiquitination, sustains AKT phosphorylation, and activates AKT-associated downstream signaling (e.g., GSK-3beta and mTOR). Clinically, higher expression is associated with vascular invasion/liver metastasis and poorer prognosis, and plasma levels may help distinguish LNLM1 from LNLM0."	0.8551
33726686	BMC cancer	2021	Circ_0003266 sponges miR-503-5p to suppress colorectal cancer progression via regulating PDCD4 expression.	hsa_circ_0003266	circ_0003266			colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	"circ_0003266 is down-regulated in colorectal cancer tissues and cell lines and functions as a tumor suppressor. It sponges miR-503-5p to relieve repression of PDCD4, thereby inhibiting proliferation/migration/invasion and promoting apoptosis in CRC cells."	0.7404
33727578	Scientific reports	2021	Genome-wide identification and characterization of circular RNA in resected hepatocellular carcinoma and background liver tissue.	hsa_circ_0041150				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0041150 is significantly down-regulated in resected HCC tissues compared with matched background normal liver tissues, supporting its potential as an HCC-associated biomarker."	0.3588
33727578	Scientific reports	2021	Genome-wide identification and characterization of circular RNA in resected hepatocellular carcinoma and background liver tissue.	hsa_circ_0025624				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0025624 is down-regulated in HCC tissues versus matched background normal liver tissues based on qPCR validation, suggesting potential relevance as an HCC-associated circRNA biomarker."	0.3588
33727578	Scientific reports	2021	Genome-wide identification and characterization of circular RNA in resected hepatocellular carcinoma and background liver tissue.	hsa_circ_0001020				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001020 is down-regulated in HCC tissues versus matched background normal liver tissues. Lower tumor expression is associated with worse recurrence-free and overall survival, indicating prognostic value."	0.4679
33727578	Scientific reports	2021	Genome-wide identification and characterization of circular RNA in resected hepatocellular carcinoma and background liver tissue.	hsa_circ_0028129				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RNA-seq	"hsa_circ_0028129 was identified by high-throughput RNA-seq as down-regulated in HCC tissues compared with paired background normal liver tissues, but its down-regulation was not reported as confirmed by qPCR or linked to prognosis in the main text."	0.1155
33727578	Scientific reports	2021	Genome-wide identification and characterization of circular RNA in resected hepatocellular carcinoma and background liver tissue.	hsa_circ_0008558				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0008558 is significantly down-regulated in HCC tissues compared with matched background normal liver tissues based on qPCR validation; mechanistic targets were not investigated.	0.3588
33727578	Scientific reports	2021	Genome-wide identification and characterization of circular RNA in resected hepatocellular carcinoma and background liver tissue.	hsa_circ_0036683				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0036683 is down-regulated in HCC tissues relative to matched background liver tissues and serves as a prognostic biomarker: low expression predicts worse RFS and OS and remains an independent factor in multivariate models; it also adds predictive value when combined with AFP.	0.5202
33727578	Scientific reports	2021	Genome-wide identification and characterization of circular RNA in resected hepatocellular carcinoma and background liver tissue.	hsa_circ_0058087				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0058087 is down-regulated in HCC and has prognostic significance: lower expression in tumor tissue correlates with worse recurrence-free and overall survival, and is an independent predictor for inferior RFS."	0.4679
33727831	OncoTargets and therapy	2021	Circ-PITX1 Promotes the Progression of Non-Small Cell Lung Cancer Through Regulating the miR-1248/CCND2 Axis.	hsa_circ_0074027		hsa_circ_PITX1	PITX1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"Circ-PITX1 is up-regulated in NSCLC tissues/cells and promotes malignant phenotypes (proliferation, migration/invasion, cell-cycle progression) and metabolic reprogramming (glycolysis and glutamine metabolism) while inhibiting apoptosis. Mechanistically, it sponges miR-1248 to relieve repression of CCND2, thereby enhancing NSCLC progression and tumor growth in xenografts."	0.7419
33728810	The Kaohsiung journal of medical sciences	2021	Circular RNA circRNA_101996 promoted cervical cancer development by regulating miR-1236-3p/TRIM37 axis.		circRNA_101996			cervical cancer	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circRNA_101996 is up-regulated in cervical cancer tissues and cell lines and promotes proliferation, cell-cycle progression, migration, and tumor growth. Mechanistically, it sponges miR-1236-3p to de-repress TRIM37, forming the circRNA_101996/miR-1236-3p/TRIM37 axis; high circRNA_101996 correlates with worse overall survival."	0.8428
33729388	Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas	2021	Hsa_circ_0002162 has a critical role in malignant progression of tongue squamous cell carcinoma through targeting miR-33a-5p.	hsa_circ_0002162				tongue squamous cell carcinoma 	MONDO:0000500	tongue squamous cell carcinoma	up-regulated	RT-qPCR	"hsa_circ_0002162 is up-regulated in TSCC cell lines and promotes malignant phenotypes (proliferation and invasion) while inhibiting apoptosis. Mechanistically, it directly binds and negatively regulates miR-33a-5p, and miR-33a-5p rescue experiments support this circRNA/miRNA interaction as functionally important."	0.6152
33731207	Journal of experimental & clinical cancer research : CR	2021	CircFAM73A promotes the cancer stem cell-like properties of gastric cancer through the miR-490-3p/HMGA2 positive feedback loop and HNRNPK-mediated beta-catenin stabilization.	hsa_circ_0002570	CircFAM73A	hsa_circ_FAM73A	FAM73A	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"CircFAM73A is up-regulated in gastric cancer and promotes CSC-like traits, proliferation, migration, metastasis, and cisplatin resistance. It sponges miR-490-3p to upregulate HMGA2 in a positive feedback loop, and also binds HNRNPK to stabilize beta-catenin, enhancing Wnt/beta-catenin signaling and malignancy."	0.8988
33732019	Cancer management and research	2021	"Hsa_circ_0015326 Promotes the Proliferation, Invasion and Migration of Ovarian Cancer Through miR-127-3p/MYB."	hsa_circ_0015326		hsa_circ_RABGAP1L	RABGAP1L	ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"hsa_circ_0015326 is up-regulated in ovarian cancer tissues and cell lines and acts as an oncogenic circRNA. It promotes proliferation, migration and invasion and inhibits apoptosis by sponging miR-127-3p to increase MYB expression, and its knockdown suppresses tumor growth in a xenograft model."	0.7554
33732022	Cancer management and research	2021	Circ_0005927 Inhibits the Progression of Colorectal Cancer by Regulating miR-942-5p/BATF2 Axis.	hsa_circ_0005927				colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	"circ_0005927 is down-regulated in colorectal cancer tissues/cells and functions as a tumor suppressor. It sponges miR-942-5p to relieve repression of BATF2, thereby inhibiting colony formation, migration and invasion, promoting apoptosis, and suppressing xenograft tumor growth."	0.7795
33732328	Experimental and therapeutic medicine	2021	CircRNA-016901 silencing attenuates irradiation-induced injury in bone mesenchymal stem cells via regulating the miR-1249-5p/HIPK2 axis.		circRNA-016901 			irradiation-induced injury 	MONDO:0043458	radiation injury	up-regulated	RT-qPCR	"In irradiated mouse BMSCs, circ-016901 is upregulated and contributes to irradiation-induced cell injury. Silencing circ-016901 protects BMSCs by increasing proliferation and autophagy and decreasing apoptosis through a circ-016901/miR-1249-5p/HIPK2 ceRNA axis."	0.6376
33733589	Journal of cellular and molecular medicine	2021	CircPVT1 up-regulation attenuates steroid-induced osteonecrosis of the femoral head through regulating miR-21-5p-mediated Smad7/TGFbeta signalling pathway.		CircPVT1 	rno_circ_PVT1	PVT1	Steroid-induced osteonecrosis of the femoral head 	MONDO:0005380	osteonecrosis	down-regulated	RT-qPCR	"CircPVT1 is down-regulated in SIONFH models. Its overexpression protects against steroid/GC-induced osteonecrosis phenotypes by promoting osteogenic differentiation and proliferation while inhibiting apoptosis. Mechanistically, CircPVT1 sponges miR-21-5p to increase Smad7 and suppress TGFbeta/Smad2/3 signaling."	0.7045
33734009	Bioengineered	2021	Circular RNA ZNF609 functions as a competing endogenous RNA in regulating E2F transcription factor 6 through competitively binding to microRNA-197-3p to promote the progression of cervical cancer progression.		circRNA ZNF609 	hsa_circ_ZNF609	ZNF609	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ-ZNF609 is up-regulated in cervical cancer tissues and cell lines and functions as an oncogenic circRNA. It sponges miR-197-3p to relieve repression of E2F6, thereby promoting proliferation, migration, invasion, and xenograft tumor growth."	0.6479
33735107	Aging	2021	"Silencing of circular RNA_0000326 inhibits cervical cancer cell proliferation, migration and invasion by boosting microRNA-338-3p-dependent down-regulation of CDK4."	hsa_circ_0000326				cervical cancer	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"circ_0000326 is up-regulated in cervical cancer tissues and cell lines and is associated with more advanced stage. Functionally, circ_0000326 promotes proliferation, cell-cycle progression, migration and invasion, and its knockdown suppresses xenograft tumor growth. Mechanistically, it acts as a miR-338-3p sponge in an Ago2-dependent manner to upregulate CDK4."	0.8429
33735323	PLoS pathogens	2021	Circular RNA circDtx1 regulates IRF3-mediated antiviral immune responses through suppression of miR-15a-5p-dependent TRIF downregulation in teleost fish.		circDtx1 	mmi_circ_Dtx1		Siniperca chuatsi rhabdovirus (SCRV) infection	MONDO:0024934	fish disease	up-regulated	RT-qPCR; RNA-seq	"In SCRV-infected teleost fish, circDtx1 is up-regulated and mainly cytoplasmic. It functions as a ceRNA that sponges miR-15a-5p to relieve repression of TRIF, thereby promoting NF-kappaB/IRF3-driven antiviral responses and inhibiting viral replication while supporting cell proliferation/viability."	0.8058
33738906	Journal of cellular and molecular medicine	2022	Circular RNA VRK1 facilitates pre-eclampsia progression via sponging miR-221-3P to regulate PTEN/Akt.	hsa_circ_0000566	circVRK1	hsa_circ_VRK1	VRK1	pre-eclampsia 	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR; Microarray	"circVRK1 (hsa_circ_0000566), derived from VRK1, is up-regulated in pre-eclampsia placental tissues. It localizes mainly in the cytoplasm and suppresses trophoblast migration, invasion and EMT by sponging miR-221-3p to derepress PTEN and reduce Akt phosphorylation/PI3K-Akt activation."	0.8405
33741901	Cell death & disease	2021	CircSPI1 acts as an oncogene in acute myeloid leukemia through antagonizing SPI1 and interacting with microRNAs.		circSPI1 	hsa_circ_SPI1	SPI1	acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; RNA-seq	"In AML, circSPI1 (mainly the Ex234-S isoform) is up-regulated and functions as an oncogene. It antagonizes SPI1/PU.1 by repressing PU.1 translation via binding eIF4AIII, and it sponges miR-1307-3p/miR-382-5p/miR-767-5p to regulate apoptosis/proliferation-related targets such as BCL2, CDK6 and p-ERK1/2. circSPI1-associated gene signatures correlate with worse clinical risk in AML cohorts."	0.8351
33741902	Cell death & disease	2021	N6-methyladenosine modification of circCUX1 confers radioresistance of hypopharyngeal squamous cell carcinoma through caspase1 pathway.		circCUX1 	hsa_circ_CUX1	CUX1	hypopharyngeal squamous cell carcinoma 	MONDO:0044638	hypopharynx squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circCUX1 is upregulated in HPSCC, especially in radioresistant tumors, and high circCUX1 predicts poor OS/DFS. METTL3-mediated m6A methylation stabilizes circCUX1, which binds caspase1 mRNA/3¡äUTR to suppress caspase1, reduce IL-1beta/IL-18 release, and promote radiotherapy tolerance; circCUX1 knockdown sensitizes HPSCC cells to irradiation."	0.8892
33744861	Aging	2021	Hsa_circ_0053063 inhibits breast cancer cell proliferation via hsa_circ_0053063/hsa-miR-330-3p/PDCD4 axis.	hsa_circ_0053063	circ_0053063 	hsa_circ_HADHA	HADHA	Breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0053063 is up-regulated in breast cancer tissues/cell lines but functions as an anti-oncogenic circRNA. It sponges miR-330-3p to de-repress PDCD4, thereby inhibiting breast cancer cell proliferation and suppressing xenograft tumor growth; it also modulates P53 protein levels via the miR-330-3p/PDCD4 axis."	0.8277
33747217	Oncology letters	2021	Bioinformatics identification of the candidate microRNAs and construction of a competing endogenous RNA regulatory network in lacrimal gland adenoid cystic carcinoma high-grade transformation.	hsa_circ_0079694				lacrimal gland adenoid cystic carcinoma high-grade transformation 	MONDO:0006262	lacrimal gland adenoid cystic carcinoma	up-regulated	Microarray	hsa_circ_0079694 was identified by circRNA microarray as an upregulated circRNA in LACC-HGT primary cells and incorporated into a predicted circRNA-miRNA-mRNA ceRNA network. Its specific biological function was not experimentally validated in this study.	0.1768
33747217	Oncology letters	2021	Bioinformatics identification of the candidate microRNAs and construction of a competing endogenous RNA regulatory network in lacrimal gland adenoid cystic carcinoma high-grade transformation.	hsa_circ_0031983				lacrimal gland adenoid cystic carcinoma high-grade transformation 	MONDO:0006262	lacrimal gland adenoid cystic carcinoma	up-regulated	Microarray	_0031983 was included as an upregulated circRNA node in the predicted LACC-HGT circRNA-miRNA-mRNA ceRNA network based on microarray profiling and interaction prediction. No direct experimental validation of its expression change or function was provided.	0.1768
33747217	Oncology letters	2021	Bioinformatics identification of the candidate microRNAs and construction of a competing endogenous RNA regulatory network in lacrimal gland adenoid cystic carcinoma high-grade transformation.	hsa_circ_0050998				lacrimal gland adenoid cystic carcinoma high-grade transformation 	MONDO:0006262	lacrimal gland adenoid cystic carcinoma	up-regulated	Microarray	_0050998 was reported as an upregulated circRNA included in the predicted circRNA-miRNA-mRNA ceRNA network for LACC-HGT derived from microarray data and interaction prediction. The study did not experimentally validate its expression change by RT-qPCR nor its downstream effects.	0.1768
33747217	Oncology letters	2021	Bioinformatics identification of the candidate microRNAs and construction of a competing endogenous RNA regulatory network in lacrimal gland adenoid cystic carcinoma high-grade transformation.	hsa_circ_0010187				lacrimal gland adenoid cystic carcinoma high-grade transformation 	MONDO:0006262	lacrimal gland adenoid cystic carcinoma	up-regulated	Microarray	_0010187 was identified as an upregulated circRNA included in the predicted LACC-HGT ceRNA network (circRNA-miRNA-mRNA) built from microarray results and in-silico interaction prediction. The paper did not validate this circRNA experimentally nor define its host gene or specific downstream targets.	0.1768
33750389	Molecular cancer	2021	CircNEIL3 regulatory loop promotes pancreatic ductal adenocarcinoma progression via miRNA sponging and A-to-I RNA-editing.		circNEIL3	hsa_circ_NEIL3	NEIL3	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circNEIL3 is upregulated in PDAC tissues/cells and promotes proliferation, migration, invasion, tumor growth and metastasis. It sponges miR-432-5p to increase ADAR1, which enhances A-to-I editing of GLI1 and drives cell-cycle progression and EMT; ADAR1 also suppresses circNEIL3 biogenesis, forming a feedback loop. High circNEIL3 expression is associated with worse OS and serves as an independent prognostic factor in PDAC."	0.8981
33750466	Military Medical Research	2021	Comprehensive circRNA-microRNA-mRNA network analysis revealed the novel regulatory mechanism of Trichosporon asahii infection.	hsa_circ_0065336				Trichosporon asahii infection 	MONDO:0000306	trichosporonosis	up-regulated	RT-qPCR; RNA-seq	"In THP-1 macrophage-like cells infected with Trichosporon asahii, hsa_circ_0065336 is up-regulated and functions as a ceRNA that sponges miR-505-3p, thereby increasing PTPN11 expression. This validated circRNA/miRNA/mRNA axis is proposed to contribute to host immune/inflammatory responses during fungal infection."	0.5491
33750466	Military Medical Research	2021	Comprehensive circRNA-microRNA-mRNA network analysis revealed the novel regulatory mechanism of Trichosporon asahii infection.	hsa_circ_0077736				Trichosporon asahii infection 	MONDO:0000306	trichosporonosis	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0077736 was identified as differentially expressed after T. asahii infection in THP-1 cells and its RNA-seq result was validated by RT-qPCR, but no specific downstream mechanism or function was reported for this circRNA."	0.3401
33750466	Military Medical Research	2021	Comprehensive circRNA-microRNA-mRNA network analysis revealed the novel regulatory mechanism of Trichosporon asahii infection.	hsa_circ_0108123				Trichosporon asahii infection 	MONDO:0000306	trichosporonosis	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0108123 was identified as differentially expressed after T. asahii infection in THP-1 cells and its RNA-seq result was validated by RT-qPCR, but no specific downstream mechanism or function was reported for this circRNA."	0.3401
33750466	Military Medical Research	2021	Comprehensive circRNA-microRNA-mRNA network analysis revealed the novel regulatory mechanism of Trichosporon asahii infection.	hsa_circ_0029624				Trichosporon asahii infection 	MONDO:0000306	trichosporonosis	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0029624 was identified as differentially expressed after T. asahii infection in THP-1 cells and its RNA-seq result was validated by RT-qPCR, but no specific downstream mechanism or function was reported for this circRNA."	0.3401
33754062	Theranostics	2021	N6-methyladenosine-induced circ1662 promotes metastasis of colorectal cancer by accelerating YAP1 nuclear localization.		circ1662	hsa_circ_YAP1	YAP1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circ1662 is upregulated in colorectal cancer and promotes invasion, migration, EMT, and lung metastasis. It binds YAP1 protein and accelerates YAP1 nuclear transport, which suppresses SMAD3 signaling; METTL3-driven m6A modification enhances circ1662 biogenesis. High circ1662 expression associates with deeper tumors and poorer overall survival, supporting its prognostic/therapeutic relevance in CRC metastasis."	0.8801
33757550	Journal of translational medicine	2021	A circular RNA derived from PLXNB2 as a valuable predictor of the prognosis of patients with acute myeloid leukaemia.	hsa_circ_0001257	circPLXNB2	hsa_circ_PLXNB2	PLXNB2	acute myeloid leukaemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; Microarray	"circPLXNB2 (hsa_circ_0001257), derived from PLXNB2, is up-regulated in AML (especially AML with EMI) and is mainly nuclear. It promotes AML cell proliferation and migration and inhibits apoptosis in vitro and in xenograft models, and is associated with poorer OS/LFS; mechanistically it is linked to increased PLXNB2 (and BCL2/cyclin D1) and decreased BAX."	0.8309
33757583	Biological research	2021	"CircRNA RSF1 regulated ox-LDL induced vascular endothelial cells proliferation, apoptosis and inflammation through modulating miR-135b-5p/HDAC1 axis in atherosclerosis."	hsa_circ_0000345	circRSF1	hsa_circ_RSF1	RSF1	Atherosclerosis 	MONDO:0005311	atherosclerosis	down-regulated	RT-qPCR	"circRSF1 (hsa_circ_0000345), derived from RSF1 and mainly localized in the cytoplasm, is down-regulated in ox-LDL-treated HUVECs (an in vitro atherosclerosis model). Functionally, circRSF1 overexpression restores proliferation and suppresses apoptosis and inflammatory responses by sponging miR-135b-5p, thereby relieving miR-135b-5p-mediated repression of HDAC1."	0.7812
33758619	Journal of Cancer	2021	CircNT5E promotes the proliferation and migration of bladder cancer via sponging miR-502-5p.		circNT5E 	hsa_circ_TLK1	TLK1	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circNT5E is up-regulated in bladder cancer tissues and promotes bladder cancer cell proliferation and migration. Mechanistically, it localizes mainly in the cytoplasm and sponges miR-502-5p to upregulate HOXC8, enhancing tumor growth in vitro and in a xenograft model; high circNT5E is associated with larger tumor size and worse overall survival."	0.817
33759638	Technology in cancer research & treatment	2021	Knockdown of circ_NEK6 Decreased 131I Resistance of Differentiated Thyroid Carcinoma via Regulating miR-370-3p/MYH9 Axis.		circ_NEK6	hsa_circ_NEK6	NEK6	differentiated thyroid carcinoma 	MONDO:0015447	differentiated thyroid carcinoma	up-regulated	RT-qPCR	"circ_NEK6 is upregulated in 131I-resistant DTC tissues and resistant cell lines. Silencing circ_NEK6 increases 131I radiosensitivity by inhibiting proliferation/migration/invasion and promoting apoptosis and DNA damage, partly through the circ_NEK6_miR-370-3p_MYH9 regulatory axis."	0.6536
33760104	Molecular medicine reports	2021	"Circular RNA hsa_circ_0072309 inhibits the proliferation, invasion and migration of gastric cancer cells via inhibition of PI3K/AKT signaling by activating PPARgamma/PTEN signaling."	hsa_circ_0072309				gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"hsa_circ_0072309 is down-regulated in gastric cancer cell lines. Its overexpression suppresses gastric cancer cell proliferation, migration and invasion by activating PPARgamma/PTEN signaling and inhibiting PI3K/AKT/mTOR phosphorylation."	0.4236
33760126	Molecular medicine reports	2021	"Circular RNA_0074027 participates in cell proliferation, apoptosis and metastasis of colorectal cancer cells through regulation of miR_525_3p."	hsa_circ_0074027				colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circRNA-0074027 is up-regulated in colorectal cancer tissues/cell lines and functions as a tumor promoter. Its knockdown inhibits proliferation and migration/invasion and increases apoptosis, at least partly by sponging miR-525-3p and modulating p53 signaling and EMT-related markers."	0.6536
33760147	Molecular medicine reports	2021	Circular RNA circ_CCT3 promotes hepatocellular carcinoma progression by regulating the miR_1287_5p/TEAD1/PTCH1/LOX axis.		circ-CCT3 	hsa_circ_CCT3	CCT3	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circ-CCT3 is upregulated in HCC and promotes proliferation, migration/invasion while inhibiting apoptosis. Mechanistically, it sponges miR-1287-5p to increase TEAD1, which activates PTCH1 and LOX transcription, and high circ-CCT3 predicts worse overall survival."	0.8427
33760208	Molecular medicine reports	2021	"Circular RNA ABCB10 promotes cell proliferation and invasion, but inhibits apoptosis via regulating the microRNA_1271_mediated Capn4/Wnt/beta_catenin signaling pathway in epithelial ovarian cancer."		circ-ABCB10 	hsa_circ_ABCB10	ABCB10	epithelial ovarian cancer 	MONDO:0005140	ovarian carcinoma	up-regulated	RT-qPCR	"In epithelial ovarian cancer cell models, circ-ABCB10 is up-regulated and promotes proliferation and invasion while inhibiting apoptosis. Mechanistically, circ-ABCB10 directly binds and negatively regulates miR-1271, leading to increased Capn4 and activation of Wnt/beta-catenin signaling."	0.6152
33760216	Oncology reports	2021	"Circular RNA hsa_circ_0001666 sponges miR_330_5p, miR_193a_5p and miR_326, and promotes papillary thyroid carcinoma progression via upregulation of ETV4."	hsa_circ_0001666	hsa_circ_000742	hsa_circ_FAM120B	FAM120B	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circ_0001666 is up-regulated in papillary thyroid carcinoma tissues and cell lines and is associated with lymph node metastasis. It promotes PTC proliferation and tumor growth and suppresses apoptosis by sponging miR-330-5p/miR-193a-5p/miR-326 to upregulate ETV4.	0.8635
33762338	Science advances	2021	A tumor-suppressive circular RNA mediates uncanonical integrin degradation by the proteasome in liver cancer.	hsa_circ_0085154	circPABPC1 	hsa_circ_PABPC1	PABPC1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"In HCC, circPABPC1 is down-regulated in tumors and acts as a tumor suppressor by inhibiting cell adhesion, migration, and metastasis. Mechanistically, it scaffolds ITGB1 with the 26S proteasome (via PSMA4) to promote ubiquitination-independent proteasomal degradation of ITGB1, dampening downstream FAK/PI3K/Akt signaling. Low circPABPC1 levels are associated with worse OS/DFS, implying potential prognostic and therapeutic relevance."	0.8428
33762580	Cell death & disease	2021	Circ-HMGA2 (hsa_circ_0027446) promotes the metastasis and epithelial-mesenchymal transition of lung adenocarcinoma cells through the miR-1236-3p/ZEB1 axis.	hsa_circ_0027446	Circ-HMGA2	hsa_circ_HMGA2	HMGA2	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circ-HMGA2 (hsa_circ_0027446) is up-regulated in LUAD tissues and cells and promotes migration/invasion and lung metastasis by inducing EMT. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-1236-3p to increase ZEB1 expression, thereby activating an EMT program."	0.8455
33777211	Oncology letters	2021	Upregulation of circ-ASPH contributes to glioma cell proliferation and aggressiveness by targeting the miR-599/AR/SOCS2-AS1 signaling pathway.		hsa_circRNA_104634 	hsa_circ_ASPH	ASPH	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR; Microarray	"circ-ASPH (hsa_circRNA_104634), derived from ASPH, is upregulated in glioma tissues/cells and its high expression correlates with worse overall survival. Functionally, it promotes proliferation, migration and invasion of glioma cells by sponging miR-599 to relieve repression of AR and consequently increasing SOCS2-AS1 expression."	0.8554
33777742	Frontiers in oncology	2021	Circular RNA CHST15 Sponges miR-155-5p and miR-194-5p to Promote the Immune Escape of Lung Cancer Cells Mediated by PD-L1.	hsa_circ_0109320	CircCHST15	hsa_circ_CHST15	CHST15	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"CircCHST15 is up-regulated in lung cancer and mainly localized in the cytoplasm. It functions as a ceRNA by sponging miR-155-5p and miR-194-5p to increase PD-L1 expression, thereby promoting tumor growth and PD-L1-mediated immune escape with altered T-cell subsets."	0.8174
33777841	Frontiers in cellular and infection microbiology	2021	Comprehensive Analyses of circRNA Expression Profiles and Function Prediction in Chicken Cecums After Eimeria tenella Infection.		circRNA2202			Eimeria tenella infection 	MONDO:1015065		unknown	RNA-seq	"circRNA2202 is differentially expressed in chicken cecal tissue after E. tenella infection and is predicted to participate in host immune responses. Its function was inferred from a circRNA_mRNA coexpression network showing positive correlation with DTX1, a Notch-related immune regulator."	0.1768
33777841	Frontiers in cellular and infection microbiology	2021	Comprehensive Analyses of circRNA Expression Profiles and Function Prediction in Chicken Cecums After Eimeria tenella Infection.		circRNA0759 			Eimeria tenella infection 	MONDO:1015065		unknown	RT-qPCR; RNA-seq	circRNA0759 is differentially expressed in chicken cecal tissue after E. tenella infection and was further validated by qRT-PCR. Network analysis suggests it may modulate immune responses by associating with DTX1 (a Notch signaling target).	0.4032
33777841	Frontiers in cellular and infection microbiology	2021	Comprehensive Analyses of circRNA Expression Profiles and Function Prediction in Chicken Cecums After Eimeria tenella Infection.		circRNA4338			Eimeria tenella infection 	MONDO:1015065		unknown	RNA-seq	"circRNA4338 is a differentially expressed circRNA in chicken cecum after E. tenella infection, predicted to contribute to immune responses. Coexpression analysis linked it with immune-related genes VPREB3 and CXCL13L3 in the resistant vs control comparison."	0.1768
33777841	Frontiers in cellular and infection microbiology	2021	Comprehensive Analyses of circRNA Expression Profiles and Function Prediction in Chicken Cecums After Eimeria tenella Infection.		circRNA2612			Eimeria tenella infection 	MONDO:1015065		unknown	RNA-seq	circRNA2612 is a differentially expressed circRNA in chicken cecum after E. tenella infection and is predicted to contribute to host immune responses. This inference is based on coexpression with IL8L1 and F2RL2 in the resistant vs susceptible comparison.	0.1768
33777841	Frontiers in cellular and infection microbiology	2021	Comprehensive Analyses of circRNA Expression Profiles and Function Prediction in Chicken Cecums After Eimeria tenella Infection.		circRNA6300 			Eimeria tenella infection 	MONDO:1015065		unknown	RT-qPCR; RNA-seq	circRNA6300 is differentially expressed in chicken cecum after E. tenella infection and was validated by qRT-PCR. Coexpression analysis suggests a potential immune-related association through correlation with RORC and CD101 expression.	0.4032
33777841	Frontiers in cellular and infection microbiology	2021	Comprehensive Analyses of circRNA Expression Profiles and Function Prediction in Chicken Cecums After Eimeria tenella Infection.		circRNA4375 			Eimeria tenella infection 	MONDO:1015065		unknown	RT-qPCR; RNA-seq	"circRNA4375 was identified as differentially expressed in chicken cecal tissues after E. tenella infection and was included among the circRNAs validated by qRT-PCR, supporting the sequencing results, but no specific downstream partners or functions were described."	0.3588
33777841	Frontiers in cellular and infection microbiology	2021	Comprehensive Analyses of circRNA Expression Profiles and Function Prediction in Chicken Cecums After Eimeria tenella Infection.		circRNA6530 			Eimeria tenella infection 	MONDO:1015065		unknown	RT-qPCR; RNA-seq	"circRNA6530 was identified as differentially expressed in chicken cecal tissues after E. tenella infection and was among the circRNAs validated by qRT-PCR, but the article did not provide a specific functional mechanism or target association for it."	0.3588
33777841	Frontiers in cellular and infection microbiology	2021	Comprehensive Analyses of circRNA Expression Profiles and Function Prediction in Chicken Cecums After Eimeria tenella Infection.		circRNA4340 			Eimeria tenella infection 	MONDO:1015065		unknown	RT-qPCR; RNA-seq	"circRNA4340 was identified as differentially expressed in chicken cecal tissues after E. tenella infection and was among the circRNAs validated by qRT-PCR, but no specific functional mechanism or targets were reported for it."	0.3588
33777841	Frontiers in cellular and infection microbiology	2021	Comprehensive Analyses of circRNA Expression Profiles and Function Prediction in Chicken Cecums After Eimeria tenella Infection.		circRNA1909 			Eimeria tenella infection 	MONDO:1015065		unknown	RT-qPCR; RNA-seq	"circRNA1909 was identified as differentially expressed in chicken cecal tissues after E. tenella infection and was among the circRNAs validated by qRT-PCR, but the paper did not report specific targets, pathways, or functions for it."	0.3588
33777926	Frontiers in cell and developmental biology	2021	Construction of circRNA-miRNA-mRNA Network for Exploring Underlying Mechanisms of Lubrication Disorder.	hsa_circ_0002075				lubrication disorder 	MONDO:0001433	vaginal disorder	up-regulated	RNA-seq	"hsa_circ_0002075 is up-regulated in vaginal epithelial tissue from women with lubrication disorder and is included as a node in the constructed ceRNA network, suggesting it may contribute to LD via circRNA_miRNA_mRNA regulation."	0.1768
33777926	Frontiers in cell and developmental biology	2021	Construction of circRNA-miRNA-mRNA Network for Exploring Underlying Mechanisms of Lubrication Disorder.	hsa_circ_0000576				lubrication disorder 	MONDO:0001433	vaginal disorder	down-regulated	RNA-seq	"hsa_circ_0000576 is down-regulated in vaginal epithelial tissue from women with lubrication disorder and is included in the study¡¯s ceRNA network, implying a potential role in LD via circRNA_miRNA_mRNA regulation."	0.1768
33777926	Frontiers in cell and developmental biology	2021	Construction of circRNA-miRNA-mRNA Network for Exploring Underlying Mechanisms of Lubrication Disorder.	hsa_circ_0069863				lubrication disorder 	MONDO:0001433	vaginal disorder	up-regulated	RNA-seq	"hsa_circ_0069863 is up-regulated in lubrication disorder and appears in the constructed ceRNA network, indicating a potential role in LD via miRNA sponging to affect downstream mRNA expression."	0.1768
33777926	Frontiers in cell and developmental biology	2021	Construction of circRNA-miRNA-mRNA Network for Exploring Underlying Mechanisms of Lubrication Disorder.	hsa_circ_0072162				lubrication disorder 	MONDO:0001433	vaginal disorder	up-regulated	RNA-seq	"hsa_circ_0072162 is up-regulated in lubrication disorder and is a component of the study¡¯s ceRNA network, suggesting potential involvement in LD via circRNA_miRNA_mRNA regulation."	0.1768
33777926	Frontiers in cell and developmental biology	2021	Construction of circRNA-miRNA-mRNA Network for Exploring Underlying Mechanisms of Lubrication Disorder.	hsa_circ_0026782				lubrication disorder 	MONDO:0001433	vaginal disorder	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0026782 is significantly up-regulated in vaginal epithelial tissue from women with lubrication disorder. It directly binds hsa-miR-874-3p and is linked to ASB2 within a ceRNA regulatory network validated by RT-qPCR and dual-luciferase assays.	0.6676
33777952	Frontiers in cell and developmental biology	2021	Revisiting the Relationship Between Alzheimer's Disease and Cancer With a circRNA Perspective.		circPICALM	hsa_circ_PICALM	PICALM	Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	dysregulated	RNA-seq	"circPICALM is one of the hub circRNAs in a CLIP-informed circRNA_miRNA_mRNA network shared between AD-associated circRNA changes and multiple cancers. It connects to miRNAs such as hsa-miR-155-5p and hsa-miR-205-5p and to inflammation/viral-response-related mRNAs, supporting a potential inflammation-linked cross-disease mechanism."	0.1768
33777952	Frontiers in cell and developmental biology	2021	Revisiting the Relationship Between Alzheimer's Disease and Cancer With a circRNA Perspective.		circRTN4	hsa_circ_RTN4	RTN4	Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	dysregulated	RNA-seq	"circRTN4 is a hub circRNA in the shared AD_cancer circRNA_miRNA_mRNA network. It connects to miRNAs including hsa-miR-142-3p, hsa-miR-205-5p, hsa-miR-21-5p and hsa-miR-320a, linking to mRNAs enriched for IL-12 response and viral-process/inflammation-related functions."	0.1768
33777952	Frontiers in cell and developmental biology	2021	Revisiting the Relationship Between Alzheimer's Disease and Cancer With a circRNA Perspective.		circMAN2A1	hsa_circ_MAN2A1	MAN2A1	Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	dysregulated	RNA-seq	"circMAN2A1 is identified as a hub node within the AD_cancer shared circRNA_miRNA_mRNA network. It is linked to hsa-miR-92a-3p in a network cluster and is discussed in relation to its parental gene MAN2A1, suggesting potential relevance to immune/inflammation-related mechanisms highlighted by enrichment analyses."	0.1768
33782039	Molecular and cellular biology	2021	Silencing of hsa_circ_0009035 Suppresses Cervical Cancer Progression and Enhances Radiosensitivity through MicroRNA 889-3p-Dependent Regulation of HOXB7.	hsa_circ_0009035		hsa_circ_RACGAP1	RACGAP1	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"hsa_circ_0009035 is up-regulated in cervical cancer tissues/cells and is linked to radioresistance. Functionally, it promotes proliferation, migration and invasion while inhibiting apoptosis, enhancing tumor growth and reducing radiosensitivity. Mechanistically, it acts as a ceRNA by sponging miR-889-3p to increase HOXB7 expression."	0.8738
33783995	Clinical and translational medicine	2021	Androgen receptor decreases renal cell carcinoma bone metastases via suppressing the osteolytic formation through altering a novel circEXOC7 regulatory axis.		circEXOC7 	hsa_circ_EXOC7	EXOC7	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR; Microarray	"circEXOC7 is up-regulated in RCC bone metastasis tissues and promotes osteolytic formation. Mechanistically, AR induces DHX9 to decrease circEXOC7, while circEXOC7 sponges miR-149-3p to elevate CSF1, thereby facilitating RBM progression."	0.8035
33784000	Clinical and translational medicine	2021	Novel circular RNA circSOBP governs amoeboid migration through the regulation of the miR-141-3p/MYPT1/p-MLC2 axis in prostate cancer.	hsa_circ_0001633	circSOBP	hsa_circ_SOBP	SOBP	prostate cancer 	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; Microarray	"circSOBP (hsa_circ_0001633), derived from SOBP, is down-regulated in prostate cancer and suppresses migration, invasion, and in vivo metastasis. It mainly localizes to the cytoplasm and acts as a miR-141-3p sponge to upregulate MYPT1, thereby modulating the MYPT1/p-MLC2 axis to inhibit amoeboid migration."	0.8426
33786605	International journal of molecular medicine	2021	Hsa_circ_0032463 acts as the tumor promoter in osteosarcoma by regulating the miR_330_3p/PNN axis.	hsa_circ_0032463	circ_0032463	hsa_circ_SIPA1L1	SIPA1L1	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"circ_0032463 is up-regulated in osteosarcoma tissues and cell lines and promotes malignant phenotypes (proliferation/viability/invasion/adhesion) while inhibiting apoptosis. Mechanistically, it acts as a ceRNA that sponges miR-330-3p, thereby relieving repression of PNN and promoting OS progression."	0.8058
33790645	Cancer management and research	2021	Circular RNA_0000629 Suppresses Bladder Cancer Progression Mediating MicroRNA-1290/CDC73.	hsa_circ_0000629	circ_0000629 			bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; Microarray	"circ_0000629 is down-regulated in bladder cancer tissues and cell lines and acts as a tumor suppressor. It mainly localizes to the cytoplasm and inhibits proliferation, migration/invasion and EMT while promoting apoptosis. Mechanistically, circ_0000629 sponges miR-1290 to increase CDC73 expression, suppressing tumor growth in xenograft models."	0.7538
33790646	Cancer management and research	2021	Downregulation of Circ_0071589 Suppresses Cisplatin Resistance in Colorectal Cancer by Regulating the MiR-526b-3p/KLF12 Axis.	hsa_circ_0071589	circ_0071589	hsa_circ_FAT1		colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0071589 is up-regulated in CDDP-resistant colorectal cancer tissues/cells and promotes cisplatin resistance and malignant behaviors. Mechanistically, it acts as a ceRNA sponge for miR-526b-3p to de-repress KLF12, thereby enhancing CDDP resistance; knockdown of circ_0071589 sensitizes CRC cells to cisplatin in vitro and in xenografts."	0.8298
33790949	Frontiers in genetics	2021	Comparative Transcriptomic Analysis to Identify the Important Coding and Non-coding RNAs Involved in the Pathogenesis of Pterygium.	hsa_circ_0007482				pterygium	MONDO:0005085	pterygium	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0007482 is up-regulated in pterygium versus paired normal conjunctiva (RNA-seq and RT-qPCR validated). The study suggests it may contribute to pterygium development and potentially relate to abnormal proliferation/recurrence, but no specific miRNA/mRNA axis was experimentally defined."	0.5909
33790949	Frontiers in genetics	2021	Comparative Transcriptomic Analysis to Identify the Important Coding and Non-coding RNAs Involved in the Pathogenesis of Pterygium.	hsa_circ_0023988				pterygium	MONDO:0005085	pterygium	unknown	RT-qPCR; RNA-seq	hsa_circ_0023988 was experimentally validated as a circular RNA in pterygium vs normal conjunctiva samples (back-splice junction confirmed by PCR/Sanger sequencing and RNase R resistance; expression assessed by RNA-seq and RT-qPCR). The paper does not provide a clear up/down direction or specific mechanism for this circRNA in pterygium in the provided text.	0.5909
33790949	Frontiers in genetics	2021	Comparative Transcriptomic Analysis to Identify the Important Coding and Non-coding RNAs Involved in the Pathogenesis of Pterygium.	hsa_circ_0004846				pterygium	MONDO:0005085	pterygium	unknown	RT-qPCR; RNA-seq	hsa_circ_0004846 was validated as a circular RNA in patient pterygium and paired normal conjunctiva samples (Sanger-confirmed back-splice junction; RNase R resistance) and its expression was assessed by RNA-seq and RT-qPCR. The provided text does not specify its dysregulation direction or downstream mechanism.	0.5909
33790949	Frontiers in genetics	2021	Comparative Transcriptomic Analysis to Identify the Important Coding and Non-coding RNAs Involved in the Pathogenesis of Pterygium.		novel_circ_0000151			pterygium	MONDO:0005085	pterygium	unknown	RT-qPCR; RNA-seq	novel_circ_0000151 is a newly identified circRNA detected in patient pterygium and paired normal conjunctiva tissues and validated for circularity (Sanger sequencing of back-splice junction and RNase R resistance). The provided text does not state its dysregulation direction or mechanism in pterygium.	0.5909
33790949	Frontiers in genetics	2021	Comparative Transcriptomic Analysis to Identify the Important Coding and Non-coding RNAs Involved in the Pathogenesis of Pterygium.		novel_circ_0012935			pterygium	MONDO:0005085	pterygium	unknown	RT-qPCR; RNA-seq	"novel_circ_0012935 is a novel circRNA detected in pterygium and paired normal conjunctiva tissues and validated for circular structure (PCR/Sanger of back-splice junction; RNase R resistance), with expression assessed by RNA-seq and RT-qPCR. No direction of change or mechanism is given in the provided text."	0.5909
33790949	Frontiers in genetics	2021	Comparative Transcriptomic Analysis to Identify the Important Coding and Non-coding RNAs Involved in the Pathogenesis of Pterygium.		hsa_circ_001730			pterygium	MONDO:0005085	pterygium	up-regulated	RNA-seq	"hsa_circ_001730 is reported as up-regulated in pterygium based on the study¡¯s differential expression profiling, and the authors consider it potentially involved in pterygium development. It was not among the circRNAs experimentally validated by RT-qPCR/Sanger/RNase R in the provided text, and no mechanism was established in this paper."	0.1768
33799408	Genes	2021	Circular RNA UVRAG Mediated by Alternative Splicing Factor NOVA1 Regulates Adhesion and Migration of Vascular Smooth Muscle Cells.		circUVRAG 	rno_circ_Uvrag	Uvrag	vein graft disease 	MONDO:0005385	vascular disorder	down-regulated	RT-qPCR; RNA-seq	"In a rat vein graft model (intimal hyperplasia context), circUVRAG is down-regulated in graft veins and mainly localizes to the cytoplasm of VSMCs. circUVRAG promotes VSMC adhesion and migration, and its biogenesis is regulated by the alternative splicing factor NOVA1 via UVRAG pre-mRNA processing."	0.7104
33815662	Oxidative medicine and cellular longevity	2021	Exosomal circEhmt1 Released from Hypoxia-Pretreated Pericytes Regulates High Glucose-Induced Microvascular Dysfunction via the NFIA/NLRP3 Pathway.		circEhmt1	mmu_circ_Ehmt1	Ehmt1	Diabetic retinopathy 	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR; Microarray	"In a diabetic retinopathy (high-glucose injury) cell model, hypoxia-pretreated pericytes release exosomes enriched in circEhmt1 that can be taken up by endotheliocytes. circEhmt1 (mainly nuclear in pericytes) increases NFIA and thereby represses NLRP3 transcription/inflammasome activity, reducing endothelial apoptosis and inflammatory cytokine release."	0.734
33816459	Frontiers in cell and developmental biology	2021	"Regulation of Circular RNA CircNFATC3 in Cancer Cells Alters Proliferation, Migration, and Oxidative Phosphorylation."	hsa_circ_0000711	circNFATC3 	hsa_circ_NFATC3	NFATC3	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	"In breast and ovarian cancer cell lines, circNFATC3 promotes proliferative and motile phenotypes and supports mitochondrial respiration/oxidative phosphorylation. siRNA knockdown reduces proliferation, migration/invasion and lowers OCR/ECAR, while circRNA mini-vector overexpression increases these phenotypes. The circRNA is mainly cytoplasmic and is predicted (database-based) to interact with Let-7 family miRNAs and multiple RBPs."	0.6956
33817257	Open life sciences	2020	"CircHIPK3/miR-381-3p axis modulates proliferation, migration, and glycolysis of lung cancer cells by regulating the AKT/mTOR signaling pathway."	hsa_circ_0021593	circHIPK3 	hsa_circ_HIPK3	HIPK3	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in lung cancer and functions as an oncogenic circRNA. It promotes proliferation, migration and glycolysis while inhibiting apoptosis by sponging miR-381-3p and activating the AKT/mTOR signaling pathway, and its knockdown suppresses tumor growth in a xenograft model."	0.7087
33817300	Open life sciences	2021	Circ_0091579 enhances the malignancy of hepatocellular carcinoma via miR-1287/PDK2 axis.	hsa_circ_0091579	circ_0091579			hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0091579 is upregulated in HCC tissues and cell lines and functions as an oncogenic circRNA. It sponges miR-1287 to increase PDK2 expression, thereby promoting proliferation and glycolysis while inhibiting apoptosis, and supports xenograft tumor growth."	0.8166
33819198	Aging	2021	circRNA expression profiling of colon tissue from mesalazine-treated mouse of inflammatory bowel disease reveals an important circRNA-miRNA-mRNA pathway.		chr10:115386962-115390436+	mmu_circ_Cnot6l	Cnot6l	inflammatory bowel disease 	MONDO:0005265	inflammatory bowel disease	up-regulated	RT-qPCR; RNA-seq	"In DSS-induced IBD mouse colon, chr10:115386962-115390436+ is up-regulated and was highlighted as a key circRNA in a predicted circRNA_miRNA_mRNA axis. The study suggests it may sponge mmu-miR-6914-5p to modulate Atg7, potentially impacting autophagy during IBD and mesalazine treatment."	0.4997
33819198	Aging	2021	circRNA expression profiling of colon tissue from mesalazine-treated mouse of inflammatory bowel disease reveals an important circRNA-miRNA-mRNA pathway.		chr12:84171460-84174423-	mmu_circ_Ttll5	Ttll5	inflammatory bowel disease 	MONDO:0005265	inflammatory bowel disease	up-regulated	RT-qPCR; RNA-seq	chr12:84171460-84174423- (host gene Ttll5) was selected from differential-expression profiling and its up-regulation in DSS-induced IBD mouse colon was validated by RT-qPCR consistent with RNA-seq. No specific downstream mechanism was established for this circRNA in the study.	0.4625
33819198	Aging	2021	circRNA expression profiling of colon tissue from mesalazine-treated mouse of inflammatory bowel disease reveals an important circRNA-miRNA-mRNA pathway.		chr13:55233895-55248077+	mmu_circ_Oma1	Oma1	inflammatory bowel disease 	MONDO:0005265	inflammatory bowel disease	down-regulated	RT-qPCR; RNA-seq	chr13:55233895-55248077+ (host gene Oma1) was down-regulated in DSS-induced IBD mouse colon and this change was validated by RT-qPCR consistent with RNA-seq. The study did not further define a specific mechanistic role for this circRNA.	0.4625
33819198	Aging	2021	circRNA expression profiling of colon tissue from mesalazine-treated mouse of inflammatory bowel disease reveals an important circRNA-miRNA-mRNA pathway.		chr4:44133640-44152553-	mmu_circ_Camta1	Camta1	inflammatory bowel disease 	MONDO:0005265	inflammatory bowel disease	down-regulated	RT-qPCR; RNA-seq	chr4:44133640-44152553- (host gene Camta1) was down-regulated in DSS-induced IBD mouse colon and this change was validated by RT-qPCR consistent with RNA-seq. The paper did not report an interaction axis or pathway specifically for this circRNA.	0.4625
33819198	Aging	2021	circRNA expression profiling of colon tissue from mesalazine-treated mouse of inflammatory bowel disease reveals an important circRNA-miRNA-mRNA pathway.		chr8:79060250-79076538+	mmu_circ_Cdk13	Cdk13	inflammatory bowel disease 	MONDO:0005265	inflammatory bowel disease	down-regulated	RT-qPCR; RNA-seq	chr8:79060250-79076538+ (host gene Cdk13) was down-regulated in DSS-induced IBD mouse colon and this was validated by RT-qPCR consistent with RNA-seq. No specific downstream targets or pathways were further characterized for this circRNA.	0.4625
33824281	Cell death & disease	2021	Circular RNA hsa_circ_101555 promotes hepatocellular carcinoma cell proliferation and migration by sponging miR-145-5p and regulating CDCA3 expression.		hsa_circ_101555 	hsa_circ_CSNK1G1	CSNK1G1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"hsa_circ_101555 is up-regulated in HCC tissues/serum and HCC cell lines and mainly localizes to the cytoplasm. It promotes HCC proliferation, migration, invasion and xenograft growth by acting as a ceRNA that sponges miR-145-5p, thereby relieving repression of CDCA3; EIF4A3 facilitates its biogenesis via CSNK1G1 pre-mRNA binding."	0.8868
33824287	Cell death discovery	2021	CircHIPK3 regulates the autophagy and apoptosis of hypoxia/reoxygenation-stimulated cardiomyocytes via the miR-20b-5p/ATG7 axis.		circular RNA HIPK3	mmu_circ_HIPK3	HIPK3	myocardial ischemia	MONDO:0024644	myocardial ischemia	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in mouse myocardial I/R and cardiomyocyte H/R injury, and it promotes excessive autophagy, ROS accumulation, and apoptosis. Mechanistically, circHIPK3 sponges miR-20b-5p to increase ATG7 expression, forming a circHIPK3/miR-20b-5p/ATG7 axis that aggravates H/R-induced injury."	0.5699
33830559	Journal of clinical laboratory analysis	2021	Tumor suppressor role of hsa_circ_0035445 in gastric cancer.	hsa_circ_0035445		hsa_circ_ALDH1A2	ALDH1A2	gastric cancer	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"hsa_circ_0035445 is down-regulated in gastric cancer tissues, patient plasma, and most gastric cancer cell lines. Functionally, increasing hsa_circ_0035445 inhibits proliferation and migration, promotes apoptosis, and induces G0/G1 arrest, supporting a tumor-suppressor role and potential diagnostic utility (ROC/AUC in tissue and plasma)."	0.737
33832516	Journal of experimental & clinical cancer research : CR	2021	Circ-MBOAT2 knockdown represses tumor progression and glutamine catabolism by miR-433-3p/GOT1 axis in pancreatic cancer.		circ-MBOAT2 	hsa_circ_MBOAT2	MBOAT2	pancreatic cancer	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"circ-MBOAT2 is up-regulated in pancreatic cancer tissues and cell lines and mainly localizes to the cytoplasm. Functionally, circ-MBOAT2 promotes malignant phenotypes and glutamine catabolism by sponging miR-433-3p to derepress GOT1, and its knockdown suppresses tumor growth in vivo."	0.7421
33833509	International journal of chronic obstructive pulmonary disease	2021	CircANKRD11 Knockdown Protects HPMECs from Cigarette Smoke Extract-Induced Injury by Regulating miR-145-5p/BRD4 Axis.	hsa_circ_0040929	circANKRD11	hsa_circ_ANKRD11	ANKRD11	chronic obstructive pulmonary disease 	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR	"circANKRD11 is up-regulated in lung tissues from smokers (with or without COPD) and in CSE-treated HPMECs. It aggravates CSE-induced endothelial injury by sponging miR-145-5p and thereby increasing BRD4, promoting apoptosis, inflammation, and oxidative stress; circANKRD11 knockdown is protective and is proposed as a diagnostic biomarker for smoker-caused COPD."	0.7277
33833570	Cancer management and research	2021	Low Expression of Circular RNA hsa_circ_0078607 Predicts Poor Prognosis in High-Grade Serous Ovarian Cancer.	hsa_circ_0078607	circ_0078607	hsa_circ_SLC22A3	SLC22A3	high-grade serous ovarian cancer 	MONDO:0005211	ovarian serous adenocarcinoma	down-regulated	RT-qPCR	"In 49 paired clinical samples, circ_0078607 is down-regulated in HGSOC tumor tissues versus adjacent non-cancerous tissues. Low circ_0078607 expression is associated with advanced FIGO stage, higher CA125, and shorter PFS/OS, and is an independent adverse prognostic factor in HGSOC."	0.4758
33833571	Cancer management and research	2021	circCEP128 Knockdown Suppresses Bladder Cancer Progression via Regulating microRNA-515-5p/SDC1 Axis.	hsa_circ_0032821	circCEP128 	hsa_circ_CEP128	CEP128	bladder cancer	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"circCEP128 is up-regulated in bladder cancer tissues and cell lines and promotes malignant phenotypes. Mechanistically, it binds (sponges) miR-515-5p to relieve repression of SDC1, thereby enhancing proliferation/migration/invasion and inhibiting apoptosis; circCEP128 knockdown suppresses xenograft tumor growth."	0.742
33833580	Cancer management and research	2021	Circular RNA CircEPB41L2 Functions as Tumor Suppressor in Hepatocellular Carcinoma Through Sponging miR-590-5p.	hsa_circ_0077837	circEPB41L2	hsa_circ_EPB41L2	EPB41L2	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"circEPB41L2 (hsa_circ_0077837), derived from EPB41L2, is down-regulated in HCC tissues and acts as a tumor suppressor. It inhibits HCC cell proliferation, migration and invasion and suppresses tumor growth in a xenograft model, at least partly by sponging miR-590-5p and modulating EMT-related markers."	0.8545
33836754	Molecular cancer	2021	A novel protein encoded by circMAPK1 inhibits progression of gastric cancer by suppressing activation of MAPK signaling.	hsa_circ_0004872	circMAPK1 	hsa_circ_MAPK1	MAPK1	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"circMAPK1 (hsa_circ_0004872) is down-regulated in gastric cancer and acts as a tumor suppressor. It inhibits GC malignant behaviors mainly by encoding MAPK1_109aa, which competitively binds MEK1 and reduces MAPK1 phosphorylation, thereby suppressing MAPK signaling. Higher circMAPK1 expression is associated with better overall survival in GC patients."	0.8913
33840258	Cell transplantation	2021	RAI14 Regulated by circNFATC3/miR-23b-3p axis Facilitates Cell Growth and Invasion in Gastric Cancer.	hsa_circ_0039930	circNFATC3	hsa_circ_NFATC3	NFATC3	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; ISH	"In gastric cancer, circNFATC3 (hsa_circ_0039930) is up-regulated and mainly localized in the cytoplasm. It promotes tumor growth and invasion by sponging miR-23b-3p to increase RAI14, and high circNFATC3 expression is linked to poorer overall survival."	0.8222
33841499	Frontiers in genetics	2021	Downregulation of hsa_circ_0004543 Activates oxLDL-Induced Vascular Endothelial Cell Proliferation and Angiogenesis.	hsa_circ_0004543	hsa_circ0004543			atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"hsa_circ_0004543 is up-regulated in oxLDL-treated HUVECs (an in vitro atherosclerosis-related endothelial injury model). Functionally, hsa_circ_0004543 acts as a negative regulator of endothelial proliferation/migration/invasion and angiogenic activity, at least partly by suppressing the PI3K/AKT/NOS3 (eNOS) pathway."	0.4635
33841577	Oncology letters	2021	"circCCDC66 promotes thyroid cancer cell proliferation, migratory and invasive abilities and glycolysis through the miR-211-5p/PDK4 axis."		circCCDC66	hsa_circ_CCDC66	CCDC66	thyroid cancer 	MONDO:0002108	thyroid cancer	up-regulated	RT-qPCR	"circCCDC66 is up-regulated in thyroid cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes TC cell proliferation, migration/invasion and glycolysis by acting as a ceRNA that sponges miR-211-5p, thereby increasing PDK4 expression (miR-211-5p/PDK4 axis)."	0.6777
33841580	Oncology letters	2021	Upregulation of circRNA_100395 sponges miR-142-3p to inhibit gastric cancer progression by targeting the PI3K/AKT axis.		circRNA_100395 			gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"circRNA_100395 is down-regulated in gastric cancer tissues/cell lines, and higher circRNA_100395 expression is associated with better overall survival. Functionally, circRNA_100395 overexpression suppresses proliferation, migration and invasion and promotes apoptosis, at least partly by sponging miR-142-3p and inhibiting the PTEN-PI3K/AKT signaling axis."	0.7126
33842379	Frontiers in oncology	2021	CircRNA circ_0092314 Induces Epithelial-Mesenchymal Transition of Pancreatic Cancer Cells via Elevating the Expression of S100P by Sponging miR-671.	hsa_circ_0092314	Circ_0092314	hsa_circ_RANBP1	RANBP1	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR	"circ_0092314 is up-regulated in PAAD tissues/cells and functions as an oncogenic circRNA. It mainly localizes to the cytoplasm and promotes proliferation, invasion and EMT by sponging miR-671 to de-repress S100P, leading to activation of AKT signaling; high expression is associated with worse patient survival."	0.8034
33842488	Frontiers in cell and developmental biology	2021	CircRNA_100395 Carried by Exosomes From Adipose-Derived Mesenchymal Stem Cells Inhibits the Malignant Transformation of Non-Small Cell Lung Carcinoma Through the miR-141-3p-LATS2 Axis.		circRNA_100395 			non-small cell lung carcinoma 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"circ_100395 is down-regulated in NSCLC tissues/cell lines. AMSC-derived exosomes delivering circ_100395 suppress NSCLC malignant phenotypes (proliferation, migration/invasion, EMT) and promote apoptosis by sponging miR-141-3p, thereby increasing LATS2 and inhibiting Hippo/YAP signaling."	0.7554
33845641	Cell transplantation	2021	CircANKRD52 Promotes the Tumorigenesis of Hepatocellular Carcinoma by Sponging miR-497-5p and Upregulating BIRC5 Expression.	hsa_circ_0026939	circANKRD52	hsa_circ_ANKRD52	ANKRD52	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	unknown	RT-qPCR; ISH	"In HCC, circANKRD52 (hsa_circ_0026939) functions as an oncogenic circRNA that promotes proliferation and invasion. It predominantly localizes to the cytoplasm and sponges miR-497-5p, thereby relieving repression of BIRC5 and enhancing tumorigenesis in vitro and in a cell line-derived xenograft model."	0.8294
33849596	Journal of orthopaedic surgery and research	2021	"Circ_0116061 regulated the proliferation, apoptosis, and inflammation of osteoarthritis chondrocytes through regulating the miR-200b-3p/SMURF2 axis."	hsa_circ_0116061	Circ_0116061			osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circ_0116061 is up-regulated in OA cartilage and promotes OA progression. Functionally, circ_0116061 knockdown increases chondrocyte proliferation while reducing apoptosis and inflammatory factor expression. Mechanistically, circ_0116061 acts as a ceRNA by sponging miR-200b-3p to relieve repression of SMURF2."	0.7032
33850880	Annals of translational medicine	2021	"High-throughput sequencing profile of laryngeal cancers: analysis of co-expression and competing endogenous RNA networks of circular RNAs, long non-coding RNAs, and messenger RNAs."	hsa_circ_0000936	SHKBP1	hsa_circ_SHKBP1	SHKBP1	laryngeal cancer 	MONDO:0002358	laryngeal carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000936 (SHKBP1) is significantly up-regulated in laryngeal cancer tissues versus adjacent noncancerous tissues based on RNA-seq, and this differential expression was confirmed by RT-qPCR in patient samples."	0.3588
33850881	Annals of translational medicine	2021	Downregulation of circ-RANBP9 in laryngeal cancer and its clinical significance.	hsa_circ_0001578	circ-RANBP9	hsa_circ_RANBP9	RANBP9	laryngeal cancer 	MONDO:0002358	laryngeal carcinoma	down-regulated	RT-qPCR; RNA-seq	"This study identified and validated circ-RANBP9 (hsa_circ_0001578, derived from RANBP9) as down-regulated in laryngeal cancer tissues and cell lines. Functionally, circ-RANBP9 acts as a tumor suppressor by inhibiting proliferation, migration/invasion and EMT, and higher expression is associated with better survival and diagnostic value. Mechanistically, the work mainly supports a predicted ceRNA network and predicted RBP interactions."	0.7733
33850895	Annals of translational medicine	2021	Circular RNA hsa-circ-000881 suppresses the progression of lung adenocarcinoma in vitro via a miR-665/PRICKLE2 axis.		hsa-circ-000881 			lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR	"Circ-000881 is down-regulated in LUAD tissues and cell lines and functions as a tumor suppressor in vitro by inhibiting proliferation, migration and invasion. Mechanistically, it acts as a ceRNA sponge for miR-665 to relieve repression of PRICKLE2, forming a circ-000881/miR-665/PRICKLE2 axis."	0.6815
33853613	Molecular cancer	2021	CircPTPRA blocks the recognition of RNA N6-methyladenosine through interacting with IGF2BP1 to suppress bladder cancer progression.	hsa_circ_0006117	circPTPRA	hsa_circ_PTPRA	PTPRA	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"circPTPRA is down-regulated in bladder cancer and functions as a tumor suppressor. It binds the m6A reader IGF2BP1 (via KH3/KH4), interferes with IGF2BP1 recognition of m6A-modified RNAs, and reduces stability/expression of oncogenic targets such as MYC and FSCN1, thereby inhibiting proliferation, migration, invasion, and metastasis."	0.8554
33854310	International journal of chronic obstructive pulmonary disease	2021	Circ-OSBPL2 Contributes to Smoke-Related Chronic Obstructive Pulmonary Disease by Targeting miR-193a-5p/BRD4 Axis.	hsa_circ_0061052	circOSBPL2 	hsa_circ_OSBPL2	OSBPL2	chronic obstructive pulmonary disease 	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR	"Circ-OSBPL2 is up-regulated in lung tissues from smokers with COPD and in CSE-treated 16HBE cells. It promotes CSE-induced epithelial injury (reduced viability/proliferation arrest, increased apoptosis, inflammation and oxidative stress) by sponging miR-193a-5p and thereby relieving repression of BRD4."	0.7785
33854374	Cancer management and research	2021	CircRNA circ-OGDH (hsa_circ_0003340) Acts as a ceRNA to Regulate Glutamine Metabolism and Esophageal Squamous Cell Carcinoma Progression by the miR-615-5p/PDX1 Axis.	hsa_circ_0003340	circ-OGDH	hsa_circ_OGDH	OGDH	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"Circ-OGDH (hsa_circ_0003340), derived from OGDH, is up-regulated in ESCC tissues and cell lines. It promotes ESCC malignant phenotypes and glutamine metabolism by sponging miR-615-5p to derepress PDX1, increasing GLS1 and supporting tumor growth in vitro and in a TE-1 xenograft model."	0.7418
33854376	Cancer management and research	2021	"Circ_0001806 Promotes the Proliferation, Migration and Invasion of NSCLC Cells Through miR-1182/NOVA2 Axis."	hsa_circ_0001806	circ_0001806			non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0001806 is up-regulated in NSCLC tissues and cell lines and promotes NSCLC cell proliferation, migration, and invasion. Mechanistically, it localizes mainly to the cytoplasm and binds miR-1182, thereby relieving miR-1182 repression and indirectly increasing NOVA2 expression."	0.6829
33854621	Journal of Cancer	2021	Circular RNA hsa_circ_0000700 promotes cell proliferation and migration in Esophageal Squamous Cell Carcinoma by sponging miR-1229.	hsa_circ_0000700		hsa_circ_CHD9	CHD9	Esophageal Squamous Cell Carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"hsa_circ_0000700 is up-regulated in ESCC cell lines and mainly localized in the cytoplasm. It promotes ESCC cell proliferation and migration and suppresses apoptosis by acting as a ceRNA sponge for miR-1229, thereby indirectly increasing PRRG4/REEP5/PSMB5 expression."	0.763
33854768	Pulmonary circulation	2021	Circular RNA-HIPK3 regulates human pulmonary artery endothelial cells function and vessel growth by regulating microRNA-328-3p/STAT3 axis.			hsa_circ_HIPK3	HIPK3	pulmonary arterial hypertension 	MONDO:0015924	pulmonary arterial hypertension	up-regulated	RT-qPCR	"In a PDGF-stimulated hPAEC PAH cell model, circHIPK3 is up-regulated and promotes endothelial proliferation, migration, and tube formation. It acts as a miRNA sponge for miR-328-3p, relieving repression on STAT3 and increasing STAT3 protein levels, thereby contributing to PAH-related vascular remodeling phenotypes."	0.7406
33858365	BMC pregnancy and childbirth	2021	Differential circular RNA expression profiles in umbilical cord blood exosomes from preeclampsia patients.	hsa_circ_0077260		hsa_circ_CGA	CGA	preeclampsia 	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR; Microarray	"circ_0077260 is up-regulated in umbilical cord blood exosomes from preeclampsia patients (validated by qPCR). Its host gene is CGA, and bioinformatics predicts it may bind PE-related miRNAs (e.g., miR-17-3p, miR-424-5p, miR-885-5p), suggesting a potential ceRNA/miRNA-sponge role in PE."	0.6521
33858365	BMC pregnancy and childbirth	2021	Differential circular RNA expression profiles in umbilical cord blood exosomes from preeclampsia patients.	hsa_circ_0090100		hsa_circ_SAT1	SAT1	preeclampsia 	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR; Microarray	"circ_0090100 is up-regulated in umbilical cord blood exosomes from preeclampsia patients (validated by qPCR). It derives from SAT1 and is predicted to bind PE-related miRNAs (miR-424-5p, miR-483-3p), implying a potential ceRNA/miRNA-sponge involvement in PE."	0.6521
33858365	BMC pregnancy and childbirth	2021	Differential circular RNA expression profiles in umbilical cord blood exosomes from preeclampsia patients.	hsa_circ_0076206		hsa_circ_MTCH1	MTCH1	preeclampsia 	MONDO:0005081	preeclampsia	down-regulated	RT-qPCR; Microarray	"circ_0076206 is down-regulated in umbilical cord blood exosomes from preeclampsia patients (validated by qPCR). It derives from MTCH1 and is predicted to bind PE-related miRNAs (miR-197-5p, miR-431-5p, miR-486-5p), suggesting a potential ceRNA/miRNA-sponge link to PE."	0.6521
33858418	Cancer cell international	2021	Circular RNA hsa_circ_0003288 induces EMT and invasion by regulating hsa_circ_0003288/miR-145/PD-L1 axis in hepatocellular carcinoma.	hsa_circ_0003288				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"hsa_circ_0003288 is up-regulated in HCC tissues/cell lines and mainly localized in the cytoplasm. It promotes EMT, migration and invasion by sponging miR-145 to de-repress PD-L1, with downstream activation of the PI3K/Akt pathway; knockdown suppresses tumor growth and EMT in xenograft models."	0.7046
33858489	Journal of experimental & clinical cancer research : CR	2021	The SRSF1/circATP5B/miR-185-5p/HOXB5 feedback loop regulates the proliferation of glioma stem cells via the IL6-mediated JAK2/STAT3 signaling pathway.	hsa_circ_0027068		hsa_circ_ATP5B	ATP5B	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circATP5B is up-regulated in glioma/GSCs and promotes GSC proliferation and in vivo tumorigenesis. It functions as a ceRNA by sponging miR-185-5p to increase HOXB5, which drives IL6-mediated JAK2/STAT3 signaling; SRSF1 binds circATP5B and enhances its expression within a feedback loop."	0.8796
33859492	International journal of general medicine	2021	Microarray Expression Profile and Analysis of Circular RNA Regulatory Network in Pulmonary Thromboembolism.	hsa_circ_0000891				Pulmonary thromboembolism 	MONDO:0005399	venous thromboembolism	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000891 is up-regulated in peripheral blood from PTE patients and was validated by RT-qPCR. The study includes it in a predicted circRNA-miRNA-mRNA ceRNA network (with hsa-miR-644 as a predicted binding miRNA), suggesting potential involvement in PTE pathogenesis."	0.4032
33859492	International journal of general medicine	2021	Microarray Expression Profile and Analysis of Circular RNA Regulatory Network in Pulmonary Thromboembolism.	hsa_circ_0043506				Pulmonary thromboembolism 	MONDO:0005399	venous thromboembolism	up-regulated	RT-qPCR; Microarray	"hsa_circ_0043506 is up-regulated in peripheral blood of PTE patients and validated by RT-qPCR. The study predicts multiple miRNA binding sites and builds a ceRNA network, proposing (speculatively) a hsa_circ_0043506_miR-942_CAPN2 regulatory axis relevant to PTE pathophysiology."	0.4032
33859754	Theranostics	2021	Hsa_circ_0030042 regulates abnormal autophagy and protects atherosclerotic plaque stability by targeting eIF4A3.	hsa_circ_0030042		hsa_circ_FOXO1	FOXO1	coronary heart disease 	MONDO:0005010	coronary artery disorder	down-regulated	RT-qPCR; Northern Blot; ISH; RNA-seq	"hsa_circ_0030042 is down-regulated in CHD and atherosclerotic plaques. It suppresses ox-LDL_induced abnormal autophagy and endothelial apoptosis, thereby improving plaque stability. Mechanistically, it acts as a cytoplasmic protein sponge for eIF4A3, reducing eIF4A3 recruitment to beclin1 and FOXO1 mRNAs and lowering their stability/expression."	0.8488
33862583	EBioMedicine	2021	Potential clinical value of circular RNAs as peripheral biomarkers for the diagnosis and treatment of major depressive disorder.	hsa_circ_0050119	circFKBP8	hsa_circ_FKBP8	FKBP8	major depressive disorder 	MONDO:0002009	major depressive disorder	down-regulated	RT-qPCR; RNA-seq	"circFKBP8 (hsa_circ_0050119) is down-regulated in whole blood of MDD patients. Its expression is associated with serum BDNF and depressive symptom measures, and it increases after rTMS with changes predicting subsequent symptom improvement. Mechanistically, it was analyzed via a predicted ceRNA network linking to downstream mRNAs (e.g., GPR68, PDXDC1, RNF213, NMT2, ABCC3), suggesting roles in neuroplasticity/neuroinflammation."	0.5849
33862583	EBioMedicine	2021	Potential clinical value of circular RNAs as peripheral biomarkers for the diagnosis and treatment of major depressive disorder.	hsa_circ_0001349	circMBNL1	hsa_circ_MBNL1	MBNL1	major depressive disorder 	MONDO:0002009	major depressive disorder	up-regulated	RT-qPCR; RNA-seq	"circMBNL1 (hsa_circ_0001349) is up-regulated in whole blood of MDD patients. Higher circMBNL1 is associated with lower HAMD-24 scores, and mediation analysis links circMBNL1 to depressive severity through serum BDNF, suggesting involvement in neuroplasticity. A predicted ceRNA network connects circMBNL1 to downstream mRNAs including MRPL48, CENPF, ZNF37A, LNPEP and TBL1X."	0.5047
33864660	Molecular medicine reports	2021	Hsa_circRNA_G004213 promotes cisplatin sensitivity by regulating miR_513b_5p/PRPF39 in liver cancer.		hsa-circRNA-G004213 			liver cancer 	MONDO:0002691	liver cancer	up-regulated	RT-qPCR; RNA-seq	"Exosomal circ-G004213 is upregulated after TACE in liver cancer. Functionally, circ-G004213 enhances cisplatin sensitivity in HepG2 cells and reduces tumor growth with improved survival in a HepG2 xenograft model. Mechanistically, it acts as a ceRNA by sponging miR-513b-5p to regulate PRPF39, and higher circ-G004213 expression is associated with better post-TACE prognosis."	0.7588
33866410	Acta neuropathologica	2021	Circular RNA profiling distinguishes medulloblastoma groups and shows aberrant RMST overexpression in WNT medulloblastoma.		circRMST	hsa_circ_RMST	RMST	medulloblastoma 	MONDO:0007959	medulloblastoma	up-regulated	RNA-seq	"circRMST is aberrantly overexpressed in WNT medulloblastoma compared to other medulloblastoma groups and is proposed as a reproducible, specific circRNA biomarker for WNT group classification."	0.1768
33867829	International journal of biological sciences	2021	Identification of low-dose radiation-induced exosomal circ-METRN and miR-4709-3p/GRB14/PDGFRalpha pathway as a key regulatory mechanism in Glioblastoma progression and radioresistance: Functional validation and clinical theranostic significance.		circ-METRN 	hsa_circ_METRN	METRN	Glioblastoma	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; Microarray	"This study identifies low-dose radiation-induced exosomes as carriers of circ-METRN, which is up-regulated in ldrEXOs and promotes glioblastoma progression and radioresistance. Mechanistically, exosomal circ-METRN sponges miR-4709-3p to derepress GRB14 and activate PDGFRalpha-associated signaling (including PI3K/AKT and MEK/ERK). Clinically, high serum exosomal circ-METRN in the first week of radiotherapy associates with early recurrence and poor prognosis and may aid MRI-based diagnosis."	0.8238
33867838	International journal of biological sciences	2021	"CircMETTL3, upregulated in a m6A-dependent manner, promotes breast cancer progression."		circMETTL3	hsa_circ_METTL3	METTL3	breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circMETTL3 is up-regulated in breast cancer tissues/cell lines and promotes proliferation, migration, invasion and xenograft tumor growth. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-31-5p to increase CDK1 expression; its expression is enhanced by m6A modification and is positively regulated by its host gene METTL3 in an m6A-dependent manner."	0.8784
33869006	Frontiers in oncology	2021	Downregulation of hsa_circ_0001836 Induces Pyroptosis Cell Death in Glioma Cells via Epigenetically Upregulating NLRP1.	hsa_circ_0001836				glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR	"In glioma cells, hsa_circ_0001836 is upregulated and its knockdown suppresses proliferation/viability and inhibits xenograft tumor growth. Mechanistically, reducing hsa_circ_0001836 decreases DNA methylation of the NLRP1 promoter, upregulates NLRP1 and activates NLRP1_caspase-1_GSDMD-mediated pyroptosis."	0.6917
33869307	Frontiers in cardiovascular medicine	2021	"circ_0003204 Regulates Cell Growth, Oxidative Stress, and Inflammation in ox-LDL-Induced Vascular Endothelial Cells via Regulating miR-942-5p/HDAC9 Axis."	hsa_circ_0003204	circ_0003204	hsa_circ_USP36	USP36	Atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"In an ox-LDL-stimulated HUVEC atherosclerosis cell model, circ_0003204 is up-regulated and exacerbates endothelial injury. Mechanistically, it sponges miR-942-5p, thereby relieving repression of HDAC9 and promoting apoptosis, oxidative stress, and inflammatory cytokine production while inhibiting cell growth/viability."	0.5974
33869627	BioMed research international	2021	circSLC8A1 Acts as a Tumor Suppressor in Prostate Cancer via Sponging miR-21.	hsa_circ_0000994	circSLC8A1	hsa_circ_SLC8A1	SLC8A1	prostate cancer 	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR	"circSLC8A1 (hsa_circ_0000994) is down-regulated in prostate cancer tissues and cell lines and functions as a tumor suppressor. It inhibits PCa cell proliferation and migration by sponging miR-21, with downstream cancer-related pathways suggested by GO/KEGG enrichment (e.g., MAPK and chemokine signaling). High circSLC8A1 expression correlates with better patient survival."	0.7618
33869778	"Open medicine (Warsaw, Poland)"	2021	Knockdown of circ_0003204 alleviates oxidative low-density lipoprotein-induced human umbilical vein endothelial cells injury: Circulating RNAs could explain atherosclerosis disease progression.	hsa_circ_0003204	circ_0003204			atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"In an ox-LDL-induced HUVEC atherosclerosis cell model, circ_0003204 is up-regulated and aggravates endothelial injury by decreasing viability and promoting apoptosis, inflammation, and oxidative stress. Mechanistically, circ_0003204 functions as a ceRNA that sponges miR-330-5p, thereby increasing TLR4 and activating the NF-kappaB pathway."	0.6253
33874956	Molecular cancer	2021	CircLIFR synergizes with MSH2 to attenuate chemoresistance via MutSalpha/ATM-p73 axis in bladder cancer.	hsa_circ_0072309	circLIFR	hsa_circ_LIFR	LIFR	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"CircLIFR (hsa_circ_0072309), derived from LIFR, is down-regulated in bladder cancer and higher expression is associated with better overall survival. It localizes mainly in the nucleus and binds MSH2, enhancing MutSalpha_ATM interaction and ATM phosphorylation to increase p73-mediated apoptosis, thereby sensitizing bladder cancer cells and xenografts/PDX tumors to cisplatin and reducing chemoresistance."	0.8931
33875631	Medical science monitor : international medical journal of experimental and clinical research	2021	Overexpression of circ_0021739 in Peripheral Blood Mononuclear Cells in Women with Postmenopausal Osteoporosis Is Associated with Reduced Expression of microRNA-194-5p in Osteoclasts.	hsa_circ_0021739	circ_0021739			postmenopausal osteoporosis 	MONDO:0008159	postmenopausal osteoporosis	down-regulated	RT-qPCR	"hsa_circ_0021739 is significantly down-regulated in PBMCs from women with PMOP and shows diagnostic potential (ROC AUC 0.849) and correlation with T-scores. Functionally, its overexpression inhibits osteoclast differentiation, likely by targeting/sponging hsa-miR-502-5p."	0.6765
33875646	Cell death & disease	2021	"Up-regulated circBACH2 contributes to cell proliferation, invasion, and migration of triple-negative breast cancer."		hsa_circ_000442	hsa_circ_BACH2	BACH2	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; Microarray	"circBACH2 is up-regulated in TNBC tissues/cell lines and promotes proliferation, migration, invasion, EMT, and in vivo tumor growth and lung metastasis. It functions as a ceRNA by sponging miR-186-5p and miR-548c-3p to increase CXCR4 expression, forming a circBACH2_miR-186-5p/miR-548c-3p_CXCR4 axis associated with malignant progression."	0.742
33879262	Biological research	2021	The role of circular RNA circ_0008285 in gestational diabetes mellitus by regulating the biological functions of trophoblasts.	hsa_circ_0008285	circ_0008285 	hsa_circ_CDYL	CDYL	gestational diabetes mellitus 	MONDO:0005406	gestational diabetes	up-regulated	RT-qPCR; RNA-seq	"circ_0008285 is upregulated in GDM patient plasma and in high glucose-treated HTR-8/SVneo trophoblast cells. Silencing circ_0008285 suppresses trophoblast proliferation, migration, and invasion under high glucose. Mechanistically, the study predicts a circ_0008285_miRNA_mRNA network and suggests involvement of PI3K/AKT signaling, supporting its potential as a serum biomarker/therapeutic target clue in GDM."	0.7477
33879262	Biological research	2021	The role of circular RNA circ_0008285 in gestational diabetes mellitus by regulating the biological functions of trophoblasts.	hsa_circ_0001173	circ_0001173 	hsa_circ_VAPB	VAPB	gestational diabetes mellitus 	MONDO:0005406	gestational diabetes	down-regulated	RT-qPCR; RNA-seq	circ_0001173 is downregulated in GDM patient plasma and also decreases in high glucose-treated HTR-8/SVneo cells. The study reports an association with glycated hemoglobin but does not experimentally define a functional mechanism for circ_0001173 in trophoblast biology.	0.5909
33879631	Aging	2021	Circular RNA hsa_circ_0072309 promotes tumorigenesis and invasion by regulating the miR-607/FTO axis in non-small cell lung carcinoma.	hsa_circ_0072309	circLIFR	hsa_circ_LIFR	LIFR	non-small cell lung carcinoma 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"hsa_circ_0072309 (circLIFR), derived from LIFR, is upregulated in NSCLC/LUAD and mainly localizes to the cytoplasm. It promotes proliferation, migration, invasion and xenograft tumor growth by sponging miR-607 and thereby upregulating the miR-607 target FTO (an m6A demethylase), establishing a hsa_circ_0072309/miR-607/FTO oncogenic axis."	0.867
33879631	Aging	2021	Circular RNA hsa_circ_0072309 promotes tumorigenesis and invasion by regulating the miR-607/FTO axis in non-small cell lung carcinoma.	hsa_circ_0000284				non-small cell lung carcinoma 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000284 is significantly upregulated in lung adenocarcinoma tissues and is strongly upregulated in lung cancer cell lines. Colony formation data suggest it affects proliferative capacity in H1975 cells, but no mechanism was characterized in this paper."	0.4625
33879631	Aging	2021	Circular RNA hsa_circ_0072309 promotes tumorigenesis and invasion by regulating the miR-607/FTO axis in non-small cell lung carcinoma.	hsa_circ_0004873				non-small cell lung carcinoma 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0004873 is upregulated in lung adenocarcinoma tissues and lung cancer cell lines in this study, but the paper does not further characterize its function or mechanism."	0.3588
33880025	International journal of nanomedicine	2021	Downregulation of hsa_circ_0074854 Suppresses the Migration and Invasion in Hepatocellular Carcinoma via Interacting with HuR and via Suppressing Exosomes-Mediated Macrophage M2 Polarization.	hsa_circ_0074854				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"This study reports that hsa_circ_0074854 (also referred to as hsa_circ_00074854) is up-regulated in HCC and promotes malignant phenotypes including proliferation, migration, invasion and EMT. Its knockdown reduces HuR protein stability via direct interaction and also limits exosome-mediated macrophage M2 polarization, together suppressing HCC progression in vitro and in xenograft models."	0.7486
33880589	Molecular medicine reports	2021	circ-PRKCI targets miR-1294 and miR-186-5p by downregulating FOXK1 expression to suppress glycolysis in hepatocellular carcinoma.		circ-PRKCI 	hsa_circ_PRKCI	PRKCI	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	unknown	RT-qPCR	"In HCCLM3 hepatocellular carcinoma cells, circ-PRKCI acts as a ceRNA that sponges miR-1294 and miR-186-5p, resulting in increased FOXK1 expression. This enhances malignant phenotypes (viability, migration, invasion) and promotes glycolysis, including upregulation of HK2/GLUT1/LDHA and increased glucose/lactic acid levels."	0.5607
33880592	Molecular medicine reports	2021	Hsa_circ_0010957 level is increased and sponges microRNA_125b in CD4+ T cells of patients with systemic lupus erythematosus.	hsa_circ_0010957		hsa_circ_SEPN1	SEPN1	systemic lupus erythematosus 	MONDO:0007915	systemic lupus erythematosus	up-regulated	RT-qPCR; Microarray	"hsa_circ_0010957 is up-regulated in SLE CD4+ T cells and functions as a ceRNA that sponges miR-125b to enhance STAT3 signaling, thereby promoting secretion of IL-18, IL-6 and IL-17. It shows diagnostic potential for distinguishing SLE (especially active disease) from controls."	0.7242
33880595	Molecular medicine reports	2021	hsa_circ_0058357 acts as a ceRNA to promote non_small cell lung cancer progression via the hsa_miR_24_3p/AVL9 axis.	hsa_circ_0058357	circ_0058357	hsa_circ_ATG9A	ATG9A	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0058357 is up-regulated in NSCLC tissues and cell lines and promotes proliferation, migration, and xenograft tumor growth while inhibiting apoptosis. It functions as a ceRNA by sponging miR-24-3p, thereby relieving miR-24-3p_mediated repression of AVL9 and driving NSCLC progression."	0.6917
33882454	Aging	2021	circUBAP2 exacerbates malignant capabilities of NSCLC by targeting KLF4 through miR-3182 modulation.		circUBAP2 	hsa_circ_UBAP2	UBAP2	Non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circUBAP2 is up-regulated in NSCLC tumor tissues and NSCLC cell lines and is enriched in the cytoplasm. It promotes proliferation, migration/invasion, and chemoresistance, and accelerates xenograft tumor growth, largely via a ceRNA mechanism sponging miR-3182 to modulate KLF4."	0.8119
33882945	World journal of surgical oncology	2021	Circ_0055625 knockdown inhibits tumorigenesis and improves radiosensitivity by regulating miR-338-3p/MSI1 axis in colon cancer.	hsa_circ_0055625	circ_0055625			colon cancer	MONDO:0021063	malignant colon neoplasm	up-regulated	RT-qPCR	"circ_0055625 is up-regulated in colon cancer and is further induced by irradiation. It promotes malignant phenotypes and radioresistance by sponging miR-338-3p to upregulate MSI1; its knockdown suppresses tumor growth and enhances radiosensitivity in vitro and in a SW480 xenograft model, and high expression correlates with poor survival."	0.7132
33883408	Chinese medical journal	2021	"Circ_0049447 acts as a tumor suppressor in gastric cancer through reducing proliferation, migration, invasion, and epithelial-mesenchymal transition."	hsa_circ_0049447	circ_0049447	hsa_circ_RAB3D	RAB3D	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"circ_0049447 (derived from RAB3D exons) is down-regulated in gastric cancer and acts as a tumor suppressor by inhibiting proliferation, migration, invasion, and EMT in GC cells and xenografts. Mechanistically, it binds (sponges) miR-324-5p (validated by luciferase), with associated upregulation of PTPRD and inhibition of beta-catenin/wnt1 signals. It shows diagnostic potential (ROC AUC 0.838) but no significant association with overall survival in this cohort."	0.7831
33883902	OncoTargets and therapy	2021	"Circ_0006168 Promotes the Migration, Invasion and Proliferation of Esophageal Squamous Cell Carcinoma Cells via miR-516b-5p-Dependent Regulation of XBP1."	hsa_circ_0006168	circ_0006168	hsa_circ_CNOT6L	CNOT6L	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"Circ_0006168 is up-regulated in ESCC tissues and cell lines and promotes ESCC cell proliferation, migration, and invasion. Mechanistically, it functions as a ceRNA by sponging miR-516b-5p, thereby increasing XBP1 expression; rescue experiments support the circ_0006168/miR-516b-5p/XBP1 axis."	0.778
33884267	BioMed research international	2021	circRNA circFAT1(e2) Elevates the Development of Non-Small-Cell Lung Cancer by Regulating miR-30e-5p and USP22.		circFAT1(e2)	hsa_circ_FAT1	FAT1	non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circFAT1(e2) is up-regulated in NSCLC tissues/cell lines and functions as an oncogenic circRNA. It sponges miR-30e-5p to increase USP22 expression, thereby promoting proliferation, migration/invasion and metastasis-related phenotypes in NSCLC cells."	0.6369
33885378	Aging	2021	circACTA2 mediates Ang II-induced VSMC senescence by modulation of the interaction of ILF3 with CDK4 mRNA.		circACTA2	hsa_circ_ACTA2	ACTA2	hypertension 	MONDO:0005044	hypertensive disorder	up-regulated	RT-qPCR; ISH	"circACTA2 is up-regulated in Ang II-stimulated human VSMCs and in renal artery tissues from hypertensive patients. It promotes VSMC senescence by binding the RBP ILF3 and competitively displacing CDK4 mRNA, thereby reducing CDK4 mRNA stability and CDK4 protein expression."	0.7785
33889522	Translational lung cancer research	2021	circFBXW7 attenuates malignant progression in lung adenocarcinoma by sponging miR-942-5p.	hsa_circ_0001451	circFBXW7	hsa_circ_FBXW7	FBXW7	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR	"In LUAD, circFBXW7 is down-regulated and functions as a tumor suppressor by inhibiting proliferation, migration, tumor growth, and EMT. Mechanistically, it sponges miR-942-5p to relieve repression of BARX2 (circFBXW7/miR-942-5p/BARX2 axis), and low circFBXW7 expression is associated with shorter DFS/OS."	0.8308
33891564	Aging	2021	CircRNA hsa_circ_0110102 inhibited macrophage activation and hepatocellular carcinoma progression via miR-580-5p/PPARalpha/CCL2 pathway.	hsa_circ_0110102	hsa_circ_ 0110102 	hsa_circ_ZNF562	ZNF562	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0110102 is down-regulated in HCC and functions as a tumor-suppressive circRNA. It sponges miR-580-5p to modulate the PPARalpha/CCL2 cascade, thereby reducing macrophage COX-2/PGE2 inflammatory activation in the tumor microenvironment and inhibiting HCC proliferation, migration and invasion."	0.7678
33892646	BMC cardiovascular disorders	2021	Circ_0004104 knockdown alleviates oxidized low-density lipoprotein-induced dysfunction in vascular endothelial cells through targeting miR-328-3p/TRIM14 axis in atherosclerosis.	hsa_circ_0004104	circ_0004104	hsa_circ_SPARC	SPARC	atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"In an ox-LDL-induced HUVEC atherosclerosis cell model, circ_0004104 is up-regulated and exacerbates endothelial injury (reduced viability/angiogenesis; increased apoptosis, inflammation, and oxidative stress). Mechanistically, circ_0004104 functions as a ceRNA by sponging miR-328-3p to up-regulate TRIM14, and circ_0004104 knockdown alleviates these dysfunctions."	0.762
33896365	Bioengineered	2021	Circular RNA hsa_circ_0000117 accelerates the proliferation and invasion of gastric cancer cells by regulating the microRNA-337-3p/signal transducer and activator of transcription 3 axis.	hsa_circ_0000117				Gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"hsa_circ_0000117 is up-regulated in gastric cancer tissues/cell lines and promotes proliferation and invasion. Mechanistically, it localizes to the cytoplasm and functions as a ceRNA sponge for miR-337-3p, thereby relieving repression of STAT3 and driving GC progression."	0.7283
33896797	Aging	2021	Circ_0007841 accelerates ovarian cancer development through facilitating MEX3C expression by restraining miR-151-3p activity.	hsa_circ_0007841	circ_0007841			ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circ_0007841 is up-regulated in ovarian cancer tissues and cell lines and promotes proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, it functions as a ceRNA that sponges miR-151-3p, thereby increasing MEX3C expression; high circ_0007841 expression is associated with poorer patient survival."	0.8025
33898108	Molecular therapy. Nucleic acids	2021	"hsa_circ_0001018 promotes papillary thyroid cancer by facilitating cell survival, invasion, G1/S cell cycle progression, and repressing cell apoptosis via crosstalk with miR-338-3p and SOX4."	hsa_circ_0001018	circ_0001018 	hsa_circ_CCT4	CCT4	papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"hsa_circ_0001018 is up-regulated in papillary thyroid cancer and mainly localizes to the cytoplasm. It promotes malignant phenotypes (survival/proliferation, migration/invasion, G1/S progression) and inhibits apoptosis by acting as a ceRNA that sponges miR-338-3p, thereby increasing SOX4 expression; its knockdown suppresses xenograft tumor growth."	0.8772
33901012	Aging	2021	Construction and topological analysis of an endometriosis-related exosomal circRNA-miRNA-mRNA regulatory network.	hsa_circ_0026129	circ_0026129 			endometriosis 	MONDO:0005133	endometriosis	dysregulated	RT-qPCR; RNA-seq	"In endometriosis, exosomal circ_0026129 is differentially expressed and functions as a ceRNA. It binds/sponges miRNA-15a-5p to de-repress ATP6V1A, potentially contributing to disease pathogenesis and serving as part of an exosomal biomarker panel."	0.5618
33901239	PloS one	2021	Upregulated hsa_circRNA_100269 inhibits the growth and metastasis of gastric cancer through inactivating PI3K/Akt axis.		hsa_circRNA_100269 			gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"hsa_circRNA_100269 is down-regulated in gastric cancer and acts as a tumor suppressor. Its overexpression inhibits proliferation, migration/invasion and EMT while promoting G0/G1 arrest and apoptosis, at least partly by inactivating the PI3K/Akt signaling axis, and it suppresses xenograft growth/metastasis in vivo."	0.622
33907219	Scientific reports	2021	CircPVT1 attenuates negative regulation of NRAS by let-7 and drives cancer cells towards oncogenicity.	hsa_circ_0001821	CircPVT1	hsa_circ_PVT1	PVT1	lung cancer 	MONDO:0008903	lung cancer	unknown	RT-qPCR	"In A549 lung cancer and HCT116 colorectal cancer cells, circPVT1 promotes oncogenic phenotypes (proliferation, migration, apoptosis resistance and EMT). Mechanistically, circPVT1 antagonizes let-7 to relieve repression of NRAS via the NRAS 3¡äUTR, and blocking let-7/NRAS binding rescues NRAS reduction and several phenotypes caused by circPVT1 knockdown."	0.6733
33907420	OncoTargets and therapy	2021	Depletion of hsa_circ_0000144 Suppresses Oxaliplatin Resistance of Gastric Cancer Cells by Regulating miR-502-5p/ADAM9 Axis.	hsa_circ_0000144		hsa_circ_SLAMF6	SLAMF6	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000144 is up-regulated in oxaliplatin-resistant gastric cancer tissues/cells and promotes OXA resistance and malignant behaviors. Mechanistically, it functions as a ceRNA by sponging miR-502-5p to increase ADAM9, and its knockdown suppresses tumor growth in a cell line-derived xenograft model."	0.7897
33907579	Oncology letters	2021	Effect of the circCDR1as/miR-641/XIAP regulatory axis on the proliferation and invasion of the prostate cancer PC-3 cell line.	hsa_circ_0001946	circCDR1as	hsa_circ_CDR1	CDR1	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circCDR1as is up-regulated in prostate cancer cell lines and promotes PC-3 cell proliferation, invasion and migration. Mechanistically, circCDR1as binds miR-641 and modulates XIAP expression via a circCDR1as/miR-641/XIAP ceRNA axis."	0.6253
33910309	Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi	2021	[Expression of circ-KEL in acute myeloid leukemia and its regulatory mechanisms in leukemic cells].	hsa_circ_0082801	circ-KEL	hsa_circ_KEL	KEL	acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"circ-KEL (hsa_circ_0082801) is up-regulated in AML and its high expression is associated with worse overall survival. Functionally, circ-KEL promotes leukemic cell proliferation and inhibits apoptosis by acting as a ceRNA that sponges miR-335-5p to increase LRG1 expression."	0.8499
33911067	Cell death & disease	2021	"Tumor-derived exosomal circPSMA1 facilitates the tumorigenesis, metastasis, and migration in triple-negative breast cancer (TNBC) through miR-637/Akt1/beta-catenin (cyclin D1) axis."		circPSMA1	hsa_circ_PSMA1	PSMA1	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; RNA-seq	"circPSMA1 is up-regulated in TNBC cells and patient serum exosomes and acts as an oncogenic exosomal circRNA. It sponges miR-637 to increase Akt1 and downstream beta-catenin/cyclin D1 (and reduce Bax), thereby promoting TNBC proliferation, migration, metastasis, cell-cycle progression, and apoptosis resistance in vitro and in a cell line-derived xenograft model."	0.8072
33911151	Scientific reports	2021	Regulatory role of non-coding RNA in ginseng rusty root symptom tissue.		novel_circ_0000349			Ginseng rusty root symptom 	Plant diseases		dysregulated	RT-qPCR; RNA-seq	"novel_circ_0000349 was identified as a differentially expressed circRNA between GRS and healthy ginseng tissues, and its expression change from RNA-seq was validated by RT-qPCR. The study did not report a specific mechanism, targets, or functional assays for this circRNA."	0.3588
33911151	Scientific reports	2021	Regulatory role of non-coding RNA in ginseng rusty root symptom tissue.		novel_circ_0000605			Ginseng rusty root symptom 	Plant diseases		dysregulated	RT-qPCR; RNA-seq	"novel_circ_0000605 was identified as a differentially expressed circRNA between GRS and healthy ginseng tissues, and its expression change from RNA-seq was validated by RT-qPCR. The study did not report a specific mechanism, targets, or functional assays for this circRNA."	0.3588
33911151	Scientific reports	2021	Regulatory role of non-coding RNA in ginseng rusty root symptom tissue.		novel_circ_0000628			Ginseng rusty root symptom 	Plant diseases		dysregulated	RT-qPCR; RNA-seq	"novel_circ_0000628 was identified as a differentially expressed circRNA between GRS and healthy ginseng tissues, and its expression change from RNA-seq was validated by RT-qPCR. The study did not report a specific mechanism, targets, or functional assays for this circRNA."	0.3588
33920880	Cancers	2021	Circular RNA in Chemonaive Lymph Node Negative Colon Cancer Patients.		circSATB2	hsa_circ_SATB2	SATB2	colon cancer 	MONDO:0021063	malignant colon neoplasm	unknown	RNA-seq	"In a cohort of 181 chemonaive stage I_II colon cancer tumors, circSATB2 presence/absence was associated with microsatellite instability status and consensus molecular subtypes. Its back-splice junction was supported by RNA-seq and validated by Sanger sequencing."	0.559
33920880	Cancers	2021	Circular RNA in Chemonaive Lymph Node Negative Colon Cancer Patients.		circFGD6 	hsa_circ_FGD6	FGD6	colon cancer 	MONDO:0021063	malignant colon neoplasm	unknown	RNA-seq	"circFGD6 was detected from RNA-seq in chemonaive stage I_II colon cancer tumors and selected as a representative candidate for method validation; its circular junction was confirmed by Sanger sequencing. No disease mechanism, pathway, or prognostic association for circFGD6 was established in this paper."	0.559
33920880	Cancers	2021	Circular RNA in Chemonaive Lymph Node Negative Colon Cancer Patients.		circKMT2C	hsa_circ_KMT2C	KMT2C	colon cancer 	MONDO:0021063	malignant colon neoplasm	unknown	RNA-seq	"circKMT2C was identified from RNA-seq in stage I_II colon cancer tumors and its back-splice junction was validated by Sanger sequencing as part of an unbiased pipeline validation. The study did not report a specific mechanism, pathway, or clinical outcome association for circKMT2C."	0.559
33920880	Cancers	2021	Circular RNA in Chemonaive Lymph Node Negative Colon Cancer Patients.		circPLEKHM3	hsa_circ_PLEKHM3	PLEKHM3	colon cancer 	MONDO:0021063	malignant colon neoplasm	unknown	RNA-seq	circPLEKHM3 was detected from RNA-seq in stage I_II colon cancer tumors and selected for unbiased validation; its back-splice junction was confirmed by Sanger sequencing. The study noted a negative correlation between circPLEKHM3 junction reads and its host gene mRNA expression but did not establish a disease mechanism or prognostic implication for this circRNA.	0.559
33920880	Cancers	2021	Circular RNA in Chemonaive Lymph Node Negative Colon Cancer Patients.		circMGA	hsa_circ_MGA	MGA	colon cancer 	MONDO:0021063	malignant colon neoplasm	unknown	RNA-seq	"In stage I_II chemonaive colon cancer, presence of circMGA (vs absence) is associated with lower relapse and better disease-free survival. The work supports circMGA as a potential prognostic biomarker, but does not define a molecular mechanism."	0.5121
33920880	Cancers	2021	Circular RNA in Chemonaive Lymph Node Negative Colon Cancer Patients.		circNAB1	hsa_circ_NAB1	NAB1	colon cancer 	MONDO:0021063	malignant colon neoplasm	unknown	RNA-seq	circNAB1 presence/absence was linked to MSI status and CMS classification in stage I_II colon cancer tumors based on RNA-seq-derived circRNA calls. The study did not provide mechanistic experiments for circNAB1.	0.459
33920880	Cancers	2021	Circular RNA in Chemonaive Lymph Node Negative Colon Cancer Patients.		circCEP192	hsa_circ_CEP192	CEP192	colon cancer 	MONDO:0021063	malignant colon neoplasm	unknown	RNA-seq	circCEP192 presence/absence was associated with MSI status and CMS groups in stage I_II colon cancer tumors as determined from RNA-seq. No mechanistic validation for circCEP192 was performed in this study.	0.459
33926347	Bioengineered	2021	Circular RNA circ_0062389 modulates papillary thyroid carcinoma progression via the miR-1179/high mobility group box 1 axis.	hsa_circ_0062389	circ_0062389 			papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0062389 is up-regulated in papillary thyroid carcinoma and functions as an oncogenic circRNA. It sponges miR-1179 to relieve repression of HMGB1, thereby promoting PTC cell proliferation/viability, migration and EMT."	0.7372
33928018	Frontiers in oncology	2020	Circ-ZFR Promotes Progression of Bladder Cancer by Upregulating WNT5A Via Sponging miR-545 and miR-1270.	hsa_circ_0072088	CircZFR 	hsa_circ_ZFR	ZFR	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"circZFR is up-regulated in bladder cancer tissues and cell lines and promotes BCa proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, circZFR sponges miR-545 and miR-1270 to derepress WNT5A and activate Wnt/beta-catenin signaling, and high circZFR is associated with poorer patient survival."	0.8252
33932142	FEBS open bio	2021	Identification of crucial noncoding RNAs and mRNAs in hypertrophic scars via RNA sequencing.	hsa_circ_0069865				hypertrophic scar 	MONDO:0005093	skin disorder	down-regulated	RNA-seq	"hsa_circ_0069865 is down-regulated in hypertrophic scar tissue and is highlighted as a key DEcircRNA in a circRNA_mRNA coexpression network, where it is coexpressed with COMP and ADAM12, suggesting a potential role in ECM-related HS pathology."	0.348
33932991	BMC cardiovascular disorders	2021	Hsa_circ_0004831 downregulation is partially responsible for atorvastatinalleviated human umbilical vein endothelial cell injuries induced by ox-LDL through targeting the miR-182-5p/CXCL12 axis.	hsa_circ_0004831		hsa_circ_RSF1	RSF1	atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"In an ox-LDL-induced HUVEC injury model of atherosclerosis, hsa_circ_0004831 is increased by ox-LDL and reduced by atorvastatin. Functionally, hsa_circ_0004831 promotes endothelial injury phenotypes (apoptosis, oxidative stress, inflammation) and attenuates atorvastatin protection by sponging miR-182-5p to upregulate CXCL12."	0.7822
33935503	OncoTargets and therapy	2021	A Novel Circular RNA circCSPP1 Promotes Liver Cancer Progression by Sponging miR-1182.	hsa_circ_0001806	circCSPP1 	hsa_circ_CSPP1	CSPP1	liver cancer 	MONDO:0002691	liver cancer	up-regulated	RT-qPCR; Microarray	"circCSPP1 is up-regulated in liver cancer tissues/cell lines and mainly localizes to the cytoplasm. It promotes malignant phenotypes (proliferation, migration, invasion, tumor growth/metastasis) by sponging miR-1182 and relieving miR-1182-mediated repression of RAB15 (ceRNA mechanism)."	0.8635
33937016	Frontiers in oncology	2021	Circular RNA hsa_circ_0013958 Functions as an Oncogenic Gene Through Modulating miR-532-3p/WEE1 Axis in Hepatocellular Carcinoma.	hsa_circ_0013958	circ0013958	hsa_circ_ACP6	ACP6	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ0013958 is up-regulated in hepatocellular carcinoma and promotes malignant phenotypes (proliferation, migration/invasion, and tumor growth) while inhibiting apoptosis. Mechanistically, it functions as a ceRNA by sponging miR-532-3p to increase WEE1 expression, and higher circ0013958 is associated with poor patient prognosis."	0.7552
33942982	Journal of cellular and molecular medicine	2021	Circ_0023404 sponges miR-136 to induce HK-2 cells injury triggered by hypoxia/reoxygenation via up-regulating IL-6R.	hsa_circ_0023404	Circ_0023404			acute kidney injury 	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR	"circ_0023404 is up-regulated in AKI patient serum and in H/R-injured HK-2 cells, and its knockdown alleviates H/R-induced injury (higher viability, less apoptosis, reduced inflammatory cytokines and oxidative stress). Mechanistically, circ_0023404 functions as a miR-136 sponge to increase IL-6R expression, forming a circ_0023404/miR-136/IL-6R axis that promotes AKI-related cellular injury in vitro."	0.6521
33943007	The Kaohsiung journal of medical sciences	2021	CircRNA ZNF609 promotes angiogenesis in nasopharyngeal carcinoma by regulating miR-145/STMN1 axis.		circRNA ZNF609 	hsa_circ_ZNF609	ZNF609	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"circ-ZNF609 is up-regulated in nasopharyngeal carcinoma tissues and cell lines and promotes NPC cell proliferation and migration and HUVEC angiogenesis. Mechanistically, it sponges miR-145 (ceRNA), thereby increasing STMN1 expression and enhancing VEGF/VEGFR-related angiogenic activity."	0.7591
33946584	Cancers	2021	"CircEHD2, CircNETO2 and CircEGLN3 as Diagnostic and Prognostic Biomarkers for Patients with Renal Cell Carcinoma."		circEHD2	hsa_circ_EHD2	EHD2	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR	"circEHD2 is upregulated in ccRCC versus normal renal tissue. High circEHD2 levels independently predict worse survival outcomes (PFS/CSS/OS) after nephrectomy, supporting its prognostic (and moderate diagnostic) biomarker value."	0.6759
33946584	Cancers	2021	"CircEHD2, CircNETO2 and CircEGLN3 as Diagnostic and Prognostic Biomarkers for Patients with Renal Cell Carcinoma."		circEGLN3	hsa_circ_EGLN3	EGLN3	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR	circEGLN3 is significantly upregulated in ccRCC tissues and provides strong diagnostic discrimination between ccRCC and normal renal tissue in this cohort. The study did not find an association between circEGLN3 expression and survival outcomes.	0.6608
33946584	Cancers	2021	"CircEHD2, CircNETO2 and CircEGLN3 as Diagnostic and Prognostic Biomarkers for Patients with Renal Cell Carcinoma."		circNETO2	hsa_circ_NETO2	NETO2	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR	"circNETO2 is upregulated in ccRCC compared with normal renal tissue. Despite being upregulated overall, lower circNETO2 expression within ccRCC patients is independently associated with worse survival outcomes, indicating prognostic value and moderate diagnostic performance."	0.6759
33946595	Biomedicines	2021	Regulation of MRP4 Expression by circHIPK3 via Sponging miR-124-3p/miR-4524-5p in Hepatocellular Carcinoma.	hsa_circ_0000284	circHIPK3	hsa_circ_HIPK3	HIPK3	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in HCC tissues and functions as a ceRNA that sponges miR-124-3p and miR-4524-5p. By reducing the availability of these miRNAs, circHIPK3 increases MRP4 protein expression, which may relate to proliferation and multidrug resistance in HCC."	0.6427
33947841	Cell death & disease	2021	Circular RNA hsa_circ_0006401 promotes proliferation and metastasis in colorectal carcinoma.	hsa_circ_0006401	hsa_circRNA_0006401	hsa_circ_COL6A3	col6a3	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH	"hsa_circ_0006401 is up-regulated in metastatic colorectal cancer and promotes aggressive phenotypes (proliferation, migration, metastasis) while inhibiting apoptosis. Mechanistically, it encodes a 198-aa peptide that promotes stabilization of COL6A3 (col6a3) mRNA and modulates COL6A3/TGFbeta1 expression, contributing to CRC progression and metastatic potential; it also shows diagnostic potential for metastatic CRC."	0.8658
33952191	"Molecular medicine (Cambridge, Mass.)"	2021	CircPTK2-miR-181c-5p-HMGB1: a new regulatory pathway for microglia activation and hippocampal neuronal apoptosis induced by sepsis.	hsa_circ_0008305	circPTK2	hsa_circ_PTK2	PTK2	sepsis 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR	"circPTK2 (hsa_circ_0008305) is up-regulated in LPS-stimulated microglia and in the hippocampus of CLP-induced sepsis mice. It promotes microglial inflammatory activation and hippocampal cell apoptosis by sponging miR-181c-5p, which in turn targets HMGB1. Silencing circPTK2 alleviates inflammation, improves mitochondrial membrane potential and cognitive performance, and increases survival in septic mice."	0.7164
33952725	Aging	2021	Tumor-derived exosomal circRNA_102481 contributes to EGFR-TKIs resistance via the miR-30a-5p/ROR1 axis in non-small cell lung cancer.		circRNA_102481 	hsa_circ_BABAM1	BABAM1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"This study reports that tumor-derived exosomal circRNA_102481 is up-regulated in EGFR-TKI_resistant NSCLC and promotes resistance by enhancing proliferation and inhibiting apoptosis. Mechanistically, circRNA_102481 functions as a ceRNA that sponges miR-30a-5p to increase ROR1 expression. High exosomal circRNA_102481 correlates with adverse clinicopathological features and shorter PFS/OS."	0.814
33952725	Aging	2021	Tumor-derived exosomal circRNA_102481 contributes to EGFR-TKIs resistance via the miR-30a-5p/ROR1 axis in non-small cell lung cancer.		circRNA_100859 			non-small cell lung cancer	MONDO:0005233	non-small cell lung carcinoma	unknown	RT-qPCR; Microarray	"circRNA_100859 is mentioned as an overexpression vector used in EGFR-TKI_sensitive NSCLC cell lines, but the text is inconsistent about whether the observed functional effects are attributable to circRNA_100859 or circRNA_102481; no clear, supported circRNA_100859_disease conclusion is provided."	0.1904
33953570	OncoTargets and therapy	2021	TCEB3 is Regulated by Circ-0000212/miR-140-3p Axis to Promote the Progression of Cervical Cancer.		circ-0000212			cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ-0000212 is up-regulated in cervical cancer tissues and promotes malignant phenotypes. It functions as a ceRNA by sponging miR-140-3p, thereby relieving repression of TCEB3 and enhancing proliferation/invasion while reducing apoptosis in cervical cancer cells."	0.7045
33954256	Open life sciences	2021	circTLK1 facilitates the proliferation and metastasis of renal cell carcinoma by regulating miR-495-3p/CBL axis.	hsa_circ_0004442	circTLK1	hsa_circ_TLK1	TLK1	renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR	"circTLK1 (hsa_circ_0004442), derived from TLK1, is up-regulated in RCC tissues and cell lines. It promotes RCC proliferation, migration/invasion, EMT and tumor growth while inhibiting apoptosis by sponging miR-495-3p to upregulate CBL."	0.6973
33955043	Journal of clinical laboratory analysis	2021	Expression profiles of circular RNAs in colon biopsies from Crohn's disease patients by microarray analysis.	hsa_circ_0062142		hsa_circ_TPTEP1	TPTEP1	Crohn's disease 	MONDO:0005011	Crohn disease	up-regulated	RT-qPCR; Microarray	"hsa_circ_0062142 is up-regulated in colon tissues from Crohn's disease patients versus UC and healthy controls, and shows diagnostic potential (AUC 0.803). Bioinformatics predicts it may function through a circRNA/miRNA/mRNA (ceRNA) network and be related to immune/inflammatory pathways implicated in CD."	0.6556
33955043	Journal of clinical laboratory analysis	2021	Expression profiles of circular RNAs in colon biopsies from Crohn's disease patients by microarray analysis.	hsa_circ_0001666		hsa_circ_FAM120B	FAM120B	Crohn's disease 	MONDO:0005011	Crohn disease	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001666 is up-regulated in colon tissues from Crohn's disease patients versus UC and healthy controls, and shows diagnostic potential (AUC 0.858). Bioinformatics predicts it may act in a circRNA/miRNA/mRNA (ceRNA) network and be linked to inflammatory/immune pathways relevant to CD."	0.6556
33957921	Cancer cell international	2021	circ_NRIP1 is oncogenic in malignant development of esophageal squamous cell carcinoma (ESCC) via miR-595/SEMA4D axis and PI3K/AKT pathway.	hsa_circ_0004771	circ_NRIP1 	hsa_circ_NRIP1	NRIP1	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"circ_NRIP1 (hsa_circ_0004771) is up-regulated in ESCC tissues and cell lines and acts as an oncogenic circRNA. It sponges miR-595 to increase SEMA4D, thereby promoting proliferation, migration/invasion and EMT-like changes while inhibiting apoptosis, and it supports tumor growth in a cell line-derived xenograft model via PI3K/AKT pathway activation."	0.7181
33957927	Parasites & vectors	2021	Circular RNA ciRS-7 affects the propagation of Cryptosporidium parvum in HCT-8 cells by sponging miR-1270 to activate the NF-kappaB signaling pathway.			hsa_circ_CDR1AS	CDR1AS	cryptosporidiosis 	MONDO:0015474	cryptosporidiosis	up-regulated	RT-qPCR; Microarray	"In C. parvum-infected HCT-8 cells, ciRS-7 is up-regulated and functions as a miRNA sponge for miR-1270. Through the ciRS-7/miR-1270/relA (p65) ceRNA axis, it activates NF-kappaB signaling (including nos2 and cxcl2) and promotes parasite propagation, with evidence also suggesting an anti-apoptotic effect via increased Bcl-2."	0.5495
33958507	Journal of microbiology and biotechnology	2021	"Knockdown of Circ_0000144 Suppresses Cell Proliferation, Migration and Invasion in Gastric Cancer Via Sponging MiR-217."	hsa_circ_0000144	circ_0000144 	hsa_circ_SLAMF6	SLAMF6	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_0000144 is up-regulated in gastric cancer tissues and cell lines and acts as an oncogenic circRNA. It promotes proliferation, migration, invasion and EMT by sponging miR-217, thereby relieving suppression of the downstream target ANLN."	0.7032
33959417	PeerJ	2021	Identification and characterization of melon circular RNAs involved in powdery mildew responses through comparative transcriptome analysis.		Cmcirc0260			powdery mildew disease 	Plant diseases		up-regulated	RT-qPCR; RNA-seq	"Cmcirc0260 is induced after powdery mildew infection, with stronger induction in the PM-resistant melon genotype than in the susceptible genotype, suggesting a role in PM response/resistance."	0.4773
33959417	PeerJ	2021	Identification and characterization of melon circular RNAs involved in powdery mildew responses through comparative transcriptome analysis.		Cmcirc0881			powdery mildew disease 	Plant diseases		up-regulated	RT-qPCR; RNA-seq	"Cmcirc0881 is up-regulated after powdery mildew infection and shows stronger induction in the resistant melon line, implicating it in PM response/resistance."	0.4773
33959417	PeerJ	2021	Identification and characterization of melon circular RNAs involved in powdery mildew responses through comparative transcriptome analysis.		Cmcirc1283			powdery mildew disease 	Plant diseases		up-regulated	RT-qPCR; RNA-seq	"Cmcirc1283 is induced by PM infection, and its induction is stronger in PM-resistant melon, suggesting involvement in PM resistance response."	0.4773
33959417	PeerJ	2021	Identification and characterization of melon circular RNAs involved in powdery mildew responses through comparative transcriptome analysis.		Cmcirc2417			powdery mildew disease 	Plant diseases		up-regulated	RT-qPCR; RNA-seq	"Cmcirc2417 is induced after PM infection (stronger in resistant melon). It was additionally validated for a back-spliced junction by divergent-primer PCR and Sanger sequencing, supporting its identity as a circRNA involved in PM response."	0.5909
33959417	PeerJ	2021	Identification and characterization of melon circular RNAs involved in powdery mildew responses through comparative transcriptome analysis.		Cmcirc3971			powdery mildew disease 	Plant diseases		up-regulated	RT-qPCR; RNA-seq	"Cmcirc3971 is up-regulated upon PM infection, with higher induction in the PM-resistant genotype, suggesting a role in melon PM defense responses."	0.4773
33959417	PeerJ	2021	Identification and characterization of melon circular RNAs involved in powdery mildew responses through comparative transcriptome analysis.		Cmcirc4093			powdery mildew disease 	Plant diseases		up-regulated	RT-qPCR; RNA-seq	"Cmcirc4093 is up-regulated after PM infection and is more strongly induced in the resistant genotype, supporting a potential role in PM resistance response."	0.4773
33959635	Frontiers in molecular biosciences	2021	"Identification of mRNA-, circRNA- and lncRNA- Associated ceRNA Networks and Potential Biomarkers for Preeclampsia From Umbilical Vein Endothelial Cells."	hsa_circ_0025992				preeclampsia 	MONDO:0005081	preeclampsia	down-regulated	RT-qPCR; Microarray	"hsa_circ_0025992 is down-regulated in PE samples (HUVECs/placenta and maternal peripheral blood) and shows diagnostic potential for early PE (ROC AUC 0.8065). It is predicted to act as a ceRNA by sponging hsa-miR-20a-3p, suggesting a possible link to endothelial dysfunction in PE."	0.5047
33959635	Frontiers in molecular biosciences	2021	"Identification of mRNA-, circRNA- and lncRNA- Associated ceRNA Networks and Potential Biomarkers for Preeclampsia From Umbilical Vein Endothelial Cells."	hsa_circ_0090396				preeclampsia 	MONDO:0005081	preeclampsia	down-regulated	RT-qPCR; Microarray	"hsa_circ_0090396 was experimentally validated by qRT-PCR and is decreased in PE-related HUVECs/placental tissues compared with controls, suggesting involvement in PE-associated endothelial dysfunction."	0.3588
33959635	Frontiers in molecular biosciences	2021	"Identification of mRNA-, circRNA- and lncRNA- Associated ceRNA Networks and Potential Biomarkers for Preeclampsia From Umbilical Vein Endothelial Cells."	hsa_circ_0066955				preeclampsia 	MONDO:0005081	preeclampsia	down-regulated	RT-qPCR; Microarray	"hsa_circ_0066955 is down-regulated in PE and was validated by qRT-PCR in HUVECs and placental tissues, indicating it may be involved in PE pathogenesis, though no specific mechanism was established."	0.3588
33959635	Frontiers in molecular biosciences	2021	"Identification of mRNA-, circRNA- and lncRNA- Associated ceRNA Networks and Potential Biomarkers for Preeclampsia From Umbilical Vein Endothelial Cells."	hsa_circ_0041203				preeclampsia 	MONDO:0005081	preeclampsia	down-regulated	RT-qPCR; Microarray	"hsa_circ_0041203 is down-regulated in PE and was validated by qRT-PCR in HUVECs and placental tissues, suggesting involvement in PE-associated molecular changes, without a specified downstream mechanism."	0.3588
33959635	Frontiers in molecular biosciences	2021	"Identification of mRNA-, circRNA- and lncRNA- Associated ceRNA Networks and Potential Biomarkers for Preeclampsia From Umbilical Vein Endothelial Cells."	hsa_circ_0018116				preeclampsia 	MONDO:0005081	preeclampsia	down-regulated	RT-qPCR; Microarray	hsa_circ_0018116 is down-regulated in PE and was validated by qRT-PCR in HUVECs and placental tissues; its specific miRNA interactions and downstream pathways were not detailed in the article.	0.3588
33960101	Journal of cellular and molecular medicine	2022	Construction of circRNA-miRNA-mRNA network in the pathogenesis of recurrent implantation failure using integrated bioinformatics study.	hsa_circ_0038383				recurrent implantation failure 	MONDO:0005047	infertility disorder	down-regulated	Microarray	This circRNA was identified as down-regulated in endometrial tissue from recurrent implantation failure patients versus fertile controls based on the GSE147442 circRNA microarray dataset. No mechanistic or functional validation was performed in this study.	0.1768
33960101	Journal of cellular and molecular medicine	2022	Construction of circRNA-miRNA-mRNA network in the pathogenesis of recurrent implantation failure using integrated bioinformatics study.	hsa_circ_0000115				recurrent implantation failure 	MONDO:0005047	infertility disorder	down-regulated	Microarray	This circRNA was reported as decreased in endometrial tissue of recurrent implantation failure patients compared with controls in the GSE147442 circRNA microarray analysis. The study did not provide experimental functional/mechanistic validation for this circRNA.	0.1768
33960101	Journal of cellular and molecular medicine	2022	Construction of circRNA-miRNA-mRNA network in the pathogenesis of recurrent implantation failure using integrated bioinformatics study.	hsa_circ_0091053				recurrent implantation failure 	MONDO:0005047	infertility disorder	down-regulated	Microarray	This circRNA was found to be down-regulated in endometrial biopsies from recurrent implantation failure patients based on circRNA microarray differential-expression analysis (GSE147442). The paper did not experimentally validate its function or construct a specific miRNA/mRNA axis for it.	0.1768
33960555	Cell proliferation	2021	CircSLC7A2 protects against osteoarthritis through inhibition of the miR-4498/TIMP3 axis.	hsa_circ_0005805	circSLC7A2 	hsa_circ_SLC7A2	SLC7A2	osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR; ISH	"circSLC7A2 is down-regulated in osteoarthritic cartilage and protects against OA by sponging miR-4498 to maintain TIMP3 expression, thereby reducing inflammation/catabolism, promoting anabolism, and limiting chondrocyte apoptosis. Its biogenesis is promoted by the RBP FUS, and intra-articular delivery alleviates OA progression in an ACLT mouse model."	0.8509
33962397	Aging	2021	Circular RNA circitga7 accelerates glioma progression via miR-34a-5p/VEGFA axis.		circITGA7	hsa_circ_ITGA7	ITGA7	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circITGA7 is up-regulated in glioma tissues and cell lines and promotes glioma cell proliferation, migration, and invasion. Mechanistically, circITGA7 functions as a ceRNA sponge for miR-34a-5p, thereby increasing VEGFA expression and driving glioma progression."	0.6479
33962616	Journal of orthopaedic surgery and research	2021	Blocking circ-CNST suppresses malignant behaviors of osteosarcoma cells and inhibits glycolysis through circ-CNST-miR-578-LDHA/PDK1 ceRNA networks.	hsa_circ_0017311	circ-CNST 	hsa_circ_CNST	CNST	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ-CNST is up-regulated in osteosarcoma tissues and cell lines and is associated with advanced clinical features and shorter overall survival. Functionally, circ-CNST promotes malignant behaviors and glycolysis by acting as a ceRNA sponge for miR-578, thereby increasing LDHA and PDK1 expression; circ-CNST knockdown suppresses tumor growth in vitro and in a cell line-derived xenograft model."	0.7482
33964939	Journal of orthopaedic surgery and research	2021	CircASH2L facilitates tumor-like biologic behaviours and inflammation of fibroblast-like synoviocytes via miR-129-5p/HIPK2 axis in rheumatoid arthritis.	hsa_circ_0083964	circASH2L 	hsa_circ_ASH2L	ASH2L	rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"circASH2L (hsa_circ_0083964), derived from ASH2L, is up-regulated in RA synovial tissues and RA-FLSs. It promotes RA-FLS tumor-like behaviors (proliferation, migration, invasion, cell cycle progression), inhibits apoptosis, and enhances inflammatory cytokine production by sponging miR-129-5p to increase HIPK2 expression."	0.6973
33967607	International journal of medical sciences	2021	has_circ_0071106 can be used as a diagnostic marker for type 2 diabetes.	hsa_circ_0071106				type 2 diabetes 	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RT-qPCR; Microarray	"In peripheral blood from a Guangzhou case-control cohort, hsa_circ_0071106 is up-regulated in T2DM and its high expression is associated with increased T2DM risk and moderate diagnostic performance (AUC up to 0.690 after adjustment). Bioinformatics predicts it may bind several miRNAs (including hsa-miR-29a-5p) and be related to MAPK signaling and transcription/protein-binding processes, but mechanisms were not experimentally validated."	0.5534
33968138	Frontiers in genetics	2021	Identification of a Potentially Functional circRNA-miRNA-mRNA Regulatory Network in Melanocytes for Investigating Pathogenesis of Vitiligo.	hsa_circ_0003164		hsa_circ_ZC3H14	ZC3H14	vitiligo 	MONDO:0008661	vitiligo	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0003164 is up-regulated in vitiligo patient skin compared with control skin, identified by circRNA-seq and validated by RT-qPCR. No specific downstream miRNA/mRNA mechanism was reported for this circRNA in the study."	0.429
33968138	Frontiers in genetics	2021	Identification of a Potentially Functional circRNA-miRNA-mRNA Regulatory Network in Melanocytes for Investigating Pathogenesis of Vitiligo.	hsa_circ_0028899		hsa_circ_RNF10	RNF10	vitiligo 	MONDO:0008661	vitiligo	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0028899 is down-regulated in vitiligo patient skin compared with control skin, identified by circRNA-seq and validated by RT-qPCR. The study did not report a specific interacting miRNA/mRNA axis for this circRNA."	0.429
33968138	Frontiers in genetics	2021	Identification of a Potentially Functional circRNA-miRNA-mRNA Regulatory Network in Melanocytes for Investigating Pathogenesis of Vitiligo.	hsa_circ_0087961	circ_0087961	hsa_circ_LPAR1	LPAR1	vitiligo 	MONDO:0008661	vitiligo	down-regulated	RNA-seq	"hsa_circ_0087961 (circ_0087961) is down-regulated in vitiligo skin by circRNA-seq. It was proposed to act in a ceRNA axis with hsa-miR-27a-3p and PXN (PAXILLIN) and may play an important regulatory role in vitiligo pathology, but this specific circRNA was not RT-qPCR-validated in the paper."	0.3991
33968165	Experimental and therapeutic medicine	2021	Circular RNA expression profiles in the plasma of patients with infantile hemangioma determined using microarray analysis.		hsa_circRNA_101566 			infantile hemangioma 	MONDO:0006500	hemangioma	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_101566 is down-regulated in plasma from proliferative infantile hemangioma patients. Bioinformatics analyses suggest it may act in a circRNA-miRNA-mRNA network (e.g., via miR-520c and NLRX1) and be linked to mTOR- and VEGF-related regulation in IH development."	0.4032
33968165	Experimental and therapeutic medicine	2021	Circular RNA expression profiles in the plasma of patients with infantile hemangioma determined using microarray analysis.		hsa_circRNA_103546			infantile hemangioma 	MONDO:0006500	hemangioma	down-regulated	RT-qPCR; Microarray	hsa_circRNA_103546 is down-regulated in plasma from proliferative infantile hemangioma patients. The study predicts it may function as a miRNA sponge (notably for miR-520c) and may be linked to metabolic/HIF-1-related processes via indirect regulation of SDHD.	0.4032
33968165	Experimental and therapeutic medicine	2021	Circular RNA expression profiles in the plasma of patients with infantile hemangioma determined using microarray analysis.		hsa_circRNA_103573			infantile hemangioma 	MONDO:0006500	hemangioma	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_103573 is down-regulated in plasma from proliferative infantile hemangioma patients. It was included in a predicted circRNA-miRNA-mRNA network, with selected angiogenesis-related miRNAs highlighted, suggesting a potential regulatory role in IH-related angiogenesis pathways."	0.4032
33968202	Oncology letters	2021	Circular RNA UBAP2 promotes the proliferation of prostate cancer cells via the miR-1244/MAP3K2 axis.		circUBAP2 	hsa_circ_UBAP2	UBAP2	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	circUBAP2 is up-regulated in prostate cancer tissues and cell lines and is mainly localized in the cytoplasm. It promotes PCa cell proliferation by sponging miR-1244 to increase MAP3K2 (with downstream MAPK factors such as ERK/JNK/p38 affected).	0.6676
33968341	Gastroenterology and hepatology from bed to bench	2021	Investigation of circRNA-miRNA-mRNA network in colorectal cancer using an integrative bioinformatics approach.	hsa_circ_0014879	circ_0014879 	hsa_circ_DCAF8	DCAF8	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	Microarray	"circ_0014879 is predicted to be up-regulated in CRC and may act as an oncogenic circRNA. Bioinformatics suggests a ceRNA axis where circ_0014879 sponges miR-885-5p, potentially increasing ARG2 expression and contributing to tumorigenesis/immune microenvironment effects."	0.1768
33968341	Gastroenterology and hepatology from bed to bench	2021	Investigation of circRNA-miRNA-mRNA network in colorectal cancer using an integrative bioinformatics approach.	hsa_circ_0001666	circ_0001666 	hsa_circ_FAM120B	FAM120B	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	Microarray	"circ_0001666 is predicted to be down-regulated in CRC and may act as a tumor-suppressive circRNA. It is proposed (bioinformatically) to sponge miR-1276, potentially impacting the tumor suppressor gene RASSF2 via a ceRNA axis."	0.1768
33968341	Gastroenterology and hepatology from bed to bench	2021	Investigation of circRNA-miRNA-mRNA network in colorectal cancer using an integrative bioinformatics approach.	hsa_circ_0000977	circ_0000977 	hsa_circ_NOL10	NOL10	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	Microarray	"circ_0000977 is predicted to be down-regulated in CRC and proposed to act as a tumor-suppressive circRNA. Bioinformatic analyses suggest it may sponge miR-1208, thereby potentially affecting tumor-suppressor genes such as IL10RA and AKR1B10 via a ceRNA mechanism."	0.1768
33968929	Frontiers in cell and developmental biology	2021	Circular RNA circSIPA1L1 Contributes to Osteosarcoma Progression Through the miR-411-5p/RAB9A Signaling Pathway.	hsa_circ_0032462	circSIPA1L1 	hsa_circ_SIPA1L1	SIPA1L1	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"circSIPA1L1 is up-regulated in osteosarcoma tissues and cell lines and mainly localizes in the cytoplasm. It promotes osteosarcoma proliferation and metastatic phenotypes by sponging miR-411-5p, thereby increasing RAB9A expression; circSIPA1L1 knockdown suppresses tumor growth in vitro and in a xenograft model."	0.8748
33969120	BioMed research international	2021	A Robust Circular RNA-Associated Three-Gene Prognostic Signature for Patients with Gastric Cancer.	hsa_circ_0081143				gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	Microarray	"hsa_circ_0081143 is computationally identified as up-regulated in gastric cancer tissues and is predicted to act as a ceRNA sponge for miR-145, thereby regulating SERPINE1. The study suggests it may have prognostic relevance in GC via the SERPINE1 link."	0.1768
33969120	BioMed research international	2021	A Robust Circular RNA-Associated Three-Gene Prognostic Signature for Patients with Gastric Cancer.	hsa_circ_0058097				gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	Microarray	"hsa_circ_0058097 is computationally identified as up-regulated in gastric cancer tissues and predicted as a hub circRNA in a ceRNA network. It may sponge multiple miRNAs (including hsa_miR_145-5p, hsa_miR_133a-3p, hsa_miR_133b and hsa_miR_1-3p) to regulate targets such as SERPINE1, COL1A1 and DKK1, potentially contributing to GC progression and prognosis."	0.1768
33969120	BioMed research international	2021	A Robust Circular RNA-Associated Three-Gene Prognostic Signature for Patients with Gastric Cancer.	hsa_circ_0091742				gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	Microarray	"hsa_circ_0091742 is computationally identified as up-regulated in gastric cancer tissues and predicted to bind miR-145, miR-196a, miR-196b and miR-552. Through these interactions it may regulate targets including SERPINE1, GCNT4 and EPHA7, potentially contributing to GC progression and prognosis."	0.1768
33969128	Journal of immunology research	2021	Circular RNA ITCH Is a Tumor Suppressor in Clear Cell Renal Cell Carcinoma Metastasis through miR-106b-5p/PDCD4 Axis.		circ-ITCH 	hsa_circ_ITCH	ITCH	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	down-regulated	RT-qPCR	"circ-ITCH is down-regulated in ccRCC tissues/cell lines and acts as a tumor suppressor by inhibiting migration and invasion. Mechanistically, it sponges miR-106b-5p to relieve repression of PDCD4, thereby suppressing ccRCC metastasis and reducing xenograft tumor growth."	0.6261
33969549	Journal of clinical laboratory analysis	2021	"Higher circular RNA_0015278 correlates with absence of extrathyroidal invasion, lower pathological tumor stages, and prolonged disease-free survival in papillary thyroid carcinoma patients."	hsa_circ_0015278				papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR	"circ_0015278 is down-regulated in PTC tumor tissue versus adjacent tissue. Higher tumor circ_0015278 levels are associated with less advanced disease features and independently predict longer disease-free survival, suggesting potential value as a clinical biomarker."	0.5918
33969826	Journal of biosciences	2021	CircRNA expression profiling and bioinformatics analysis indicate the potential biological role and clinical significance of circRNA in influenza A virus-induced lung injury.	hsa_circ_0003252	circRNA Slco3a1 	hsa_circ_SLCO3A1	Slco3a1	influenza A virus-induced lung injury 	MONDO:0005812	influenza	up-regulated	RT-qPCR; RNA-seq	"CircRNA Slco3a1 (mmu_circ_0014392/hsa_circ_0003252) is up-regulated in IAV-induced lung injury in mice and in plasma from IAV-induced ARDS patients. The study predicts circRNA_miRNA interactions and enrichment in processes such as mitochondrial function/superoxide metabolism and pathways including Hippo and oxidative phosphorylation, suggesting a potential regulatory role during lung injury."	0.5623
33969826	Journal of biosciences	2021	CircRNA expression profiling and bioinformatics analysis indicate the potential biological role and clinical significance of circRNA in influenza A virus-induced lung injury.	mmu_circ_0014392	circRNA Slco3a1 	mmu_circ_Slco3a1	Slco3a1	influenza A virus-induced lung injury 	MONDO:0005812	influenza	up-regulated	RT-qPCR; RNA-seq	"CircRNA Slco3a1 (mmu_circ_0014392/hsa_circ_0003252) is up-regulated in IAV-induced lung injury in mice and in plasma from IAV-induced ARDS patients. The study predicts circRNA_miRNA interactions and enrichment in processes such as mitochondrial function/superoxide metabolism and pathways including Hippo and oxidative phosphorylation, suggesting a potential regulatory role during lung injury."	0.5623
33969826	Journal of biosciences	2021	CircRNA expression profiling and bioinformatics analysis indicate the potential biological role and clinical significance of circRNA in influenza A virus-induced lung injury.	hsa_circ_0003192	circRNA Wdr33 	hsa_circ_WDR33	Wdr33	influenza A virus-induced lung injury 	MONDO:0005812	influenza	down-regulated	RT-qPCR; RNA-seq	"CircRNA Wdr33 (mmu_circ_0000858/hsa_circ_0003192) is down-regulated in IAV-induced lung injury in mice and in plasma from IAV-induced ARDS patients. The study builds predicted circRNA_miRNA interaction networks and enrichment results implicating processes such as mitochondrial function/superoxide metabolism and pathways including Hippo, oxidative phosphorylation, and Notch, suggesting potential regulatory involvement in lung injury."	0.5623
33969826	Journal of biosciences	2021	CircRNA expression profiling and bioinformatics analysis indicate the potential biological role and clinical significance of circRNA in influenza A virus-induced lung injury.	mmu_circ_0000858	circRNA Wdr33 	mmu_circ_Wdr33	Wdr33	influenza A virus-induced lung injury 	MONDO:0005812	influenza	down-regulated	RT-qPCR; RNA-seq	"CircRNA Wdr33 (mmu_circ_0000858/hsa_circ_0003192) is down-regulated in IAV-induced lung injury in mice and in plasma from IAV-induced ARDS patients. The study builds predicted circRNA_miRNA interaction networks and enrichment results implicating processes such as mitochondrial function/superoxide metabolism and pathways including Hippo, oxidative phosphorylation, and Notch, suggesting potential regulatory involvement in lung injury."	0.5623
33969826	Journal of biosciences	2021	CircRNA expression profiling and bioinformatics analysis indicate the potential biological role and clinical significance of circRNA in influenza A virus-induced lung injury.	mmu_circ_0009613	circRNA Nfatc2 	mmu_circ_Nfatc2	Nfatc2	influenza A virus-induced lung injury 	MONDO:0005812	influenza	up-regulated	RT-qPCR; RNA-seq	"mmu_circ_0009613 (circRNA Nfatc2) is significantly up-regulated in lung tissues from IAV-infected mice versus controls, supported by sequencing and qPCR validation. No specific downstream mechanism or pathway was established for this circRNA in the paper."	0.4062
33969826	Journal of biosciences	2021	CircRNA expression profiling and bioinformatics analysis indicate the potential biological role and clinical significance of circRNA in influenza A virus-induced lung injury.	mmu_circ_0016387	circRNA Dmd 	mmu_circ_Dmd	Dmd	influenza A virus-induced lung injury 	MONDO:0005812	influenza	down-regulated	RT-qPCR; RNA-seq	"mmu_circ_0016387 (circRNA Dmd) is significantly down-regulated in lung tissues from IAV-infected mice versus controls, supported by sequencing and qPCR validation. The paper does not define a specific mechanistic axis or pathway for this circRNA."	0.4062
33973871	Aging	2021	CircRNA_30032 promotes renal fibrosis in UUO model mice via miRNA-96-5p/HBEGF/KRAS axis.		circular RNA_30032 			renal fibrosis 	MONDO:0000494	renal fibrosis	up-regulated	RT-qPCR; Microarray	"In UUO mouse kidneys and TGF-beta1-treated BUMPT cells, circRNA_30032 is upregulated and promotes renal fibrosis/ECM protein accumulation. Mechanistically, it acts as a cytoplasmic ceRNA that sponges miR-96-5p to increase HBEGF and KRAS, and its induction is linked to p38 MAPK signaling. Silencing circRNA_30032 attenuates UUO-induced fibrosis, suggesting therapeutic potential."	0.692
33975612	Journal of orthopaedic surgery and research	2021	Circular RNA circ_0128846 promotes the progression of osteoarthritis by regulating miR-127-5p/NAMPT axis.	hsa_circ_0128846	circ_0128846 	hsa_circ_ZFR	ZFR	osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circ_0128846 is upregulated in OA cartilage and promotes OA-related chondrocyte apoptosis, inflammation, and ECM degradation while suppressing viability. Mechanistically, it functions as a miRNA sponge for miR-127-5p to increase NAMPT expression (circ_0128846/miR-127-5p/NAMPT axis)."	0.7551
33975615	Journal of experimental & clinical cancer research : CR	2021	Warburg effect-promoted exosomal circ_0072083 releasing up-regulates NANGO expression through multiple pathways and enhances temozolomide resistance in glioma.	hsa_circ_0072083	circ_0072083	hsa_circ_ZFR	ZFR	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR	"Exosomal circ_0072083 is up-regulated in TMZ-resistant glioma and promotes TMZ chemoresistance. It sponges miR-1252-5p to increase ALKBH5 and NANOG, and enhances ALKBH5-mediated m6A demethylation to stabilize NANOG mRNA. Warburg effect increases the release of exosomal circ_0072083, enabling transfer of resistance to sensitive glioma cells."	0.8712
33976115	Cell death discovery	2021	CircRNA_2646 functions as a ceRNA to promote progression of esophageal squamous cell carcinoma via inhibiting miR-124/PLP2 signaling pathway.		CircRNA_2646 			esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"CircRNA_2646 is up-regulated in ESCC and promotes malignant progression (proliferation, migration, invasion, EMT) while inhibiting apoptosis. Mechanistically, it functions as a ceRNA by sponging miR-124, thereby relieving repression of PLP2 and promoting ESCC growth in vitro and in a xenograft model; high expression is associated with worse survival."	0.7414
33976128	Nature communications	2021	The RNA landscape of the human placenta in health and disease.		CDR1as 	hsa_circ_CDR1	CDR1	Preeclampsia	MONDO:0005081	preeclampsia	unknown	RT-qPCR; RNA-seq	CDR1as (CiRS-7) is present in human placental RNA datasets and was experimentally confirmed by RT-qPCR and Sanger sequencing of the back-splice junction. It is described as a miRNA sponge with many predicted miR-7(-5p) binding sites; disease-associated expression/roles (PE/FGR) were not reported for this circRNA.	0.4773
33976128	Nature communications	2021	The RNA landscape of the human placenta in health and disease.	hsa_circ_0140572	circSTS	hsa_circ_STS	STS	Preeclampsia	MONDO:0005081	preeclampsia	unknown	RT-qPCR; RNA-seq	"circSTS (hsa_circ_0140572) is a placental circRNA proposed as a candidate miRNA sponge, with predicted binding sites for miR-5584-5p and miR-7113-5p. Its back-splice junction was validated by divergent PCR/RT-qPCR and confirmed by Sanger sequencing; no PE/FGR-specific expression change was reported for this circRNA."	0.5541
33976128	Nature communications	2021	The RNA landscape of the human placenta in health and disease.	hsa_circ_0027902				Preeclampsia	MONDO:0005081	preeclampsia	unknown	RNA-seq	"hsa_circ_0027902 is one of two placental circRNAs for which the authors report peptide-spectrum matches uniquely mapping to a peptide spanning its back-splice junction, suggesting potential circRNA translation. No PE/FGR-specific expression change or functional mechanism beyond translation evidence was established."	0.1768
33976128	Nature communications	2021	The RNA landscape of the human placenta in health and disease.	hsa_circ_0008923				Preeclampsia	MONDO:0005081	preeclampsia	unknown	RNA-seq	"hsa_circ_0008923 is reported as a placental circRNA with peptide-spectrum matches uniquely supporting a peptide spanning its back-splice junction, consistent with potential circRNA translation. No disease-specific (PE/FGR) association was reported for this circRNA."	0.1768
33976128	Nature communications	2021	The RNA landscape of the human placenta in health and disease.		CDR1as 	hsa_circ_CDR1	CDR1	fetal growth restriction	MONDO:0005030	fetal growth restriction	unknown	RT-qPCR; RNA-seq	CDR1as (CiRS-7) is present in human placental RNA datasets and was experimentally confirmed by RT-qPCR and Sanger sequencing of the back-splice junction. It is described as a miRNA sponge with many predicted miR-7(-5p) binding sites; disease-associated expression/roles (PE/FGR) were not reported for this circRNA.	0.4773
33976128	Nature communications	2021	The RNA landscape of the human placenta in health and disease.	hsa_circ_0140572	circSTS	hsa_circ_STS	STS	fetal growth restriction	MONDO:0005030	fetal growth restriction	unknown	RT-qPCR; RNA-seq	"circSTS (hsa_circ_0140572) is a placental circRNA proposed as a candidate miRNA sponge, with predicted binding sites for miR-5584-5p and miR-7113-5p. Its back-splice junction was validated by divergent PCR/RT-qPCR and confirmed by Sanger sequencing; no PE/FGR-specific expression change was reported for this circRNA."	0.5541
33976128	Nature communications	2021	The RNA landscape of the human placenta in health and disease.	hsa_circ_0027902				fetal growth restriction	MONDO:0005030	fetal growth restriction	unknown	RNA-seq	"hsa_circ_0027902 is one of two placental circRNAs for which the authors report peptide-spectrum matches uniquely mapping to a peptide spanning its back-splice junction, suggesting potential circRNA translation. No PE/FGR-specific expression change or functional mechanism beyond translation evidence was established."	0.1768
33976128	Nature communications	2021	The RNA landscape of the human placenta in health and disease.	hsa_circ_0008923				fetal growth restriction	MONDO:0005030	fetal growth restriction	unknown	RNA-seq	"hsa_circ_0008923 is reported as a placental circRNA with peptide-spectrum matches uniquely supporting a peptide spanning its back-splice junction, consistent with potential circRNA translation. No disease-specific (PE/FGR) association was reported for this circRNA."	0.1768
33976128	Nature communications	2021	The RNA landscape of the human placenta in health and disease.		"chr19:53,687,886-53,694,145"			preeclampsia 	MONDO:0005081	preeclampsia	dysregulated	RT-qPCR; RNA-seq	"The circRNA at chr19:53,687,886-53,694,145 is reported as one of two circRNAs differentially regulated in placentas from pregnancies complicated by PE and/or FGR, and it is present across all RNA-seq samples analyzed. The authors validated this circRNA by qPCR and confirmed its back-splice junction by Sanger sequencing; no downstream mechanism or pathway was established."	0.4773
33976535	"Drug design, development and therapy"	2021	Exosomal Circ-XIAP Promotes Docetaxel Resistance in Prostate Cancer by Regulating miR-1182/TPD52 Axis.		circ-XIAP 	hsa_circ_XIAP	XIAP	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circ-XIAP is upregulated in docetaxel-resistant prostate cancer tissues/cells and enriched in exosomes. It promotes DTX resistance by acting as a sponge for miR-1182, thereby increasing TPD52 expression, enhancing malignant phenotypes and reducing chemosensitivity in vitro and in a xenograft model."	0.7421
33976734	Journal of Cancer	2021	Hsa_circ_0091581 promotes glioma progression by regulating RMI1 via sponging miR-1243-5p.	hsa_circ_0091581	circ_0091581 	hsa_circ_GPC3	GPC3	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR	"hsa_circ_0091581 is up-regulated in glioma tissues and cell lines and promotes glioma cell proliferation, migration, and invasion. Mechanistically, it acts as a ceRNA by sponging miR-1243-5p to increase RMI1, and its knockdown suppresses tumor growth in a U87 xenograft model."	0.7792
33976745	Journal of Cancer	2021	Circular RNA ZNF609 promotes the malignant progression of glioma by regulating miR-1224-3p/PLK1 signaling.	hsa_circ_0000615	circRNA RNA ZNF609	hsa_circ_ZNF609	ZNF609	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ-ZNF609 is up-regulated in glioma and promotes malignant phenotypes (proliferation, migration, invasion) and xenograft tumor growth. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-1224-3p to increase PLK1 expression, forming a circ-ZNF609/miR-1224-3p/PLK1 axis associated with poor prognosis."	0.8439
33976984	PeerJ	2021	Identification and comparison of circular RNAs in preeclampsia.	hsa_circ_0001289				Preeclampsia 	MONDO:0005081	preeclampsia	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0001289 was identified as a differentially expressed circRNA in leukocytes from preeclampsia patients versus healthy pregnant women using RNA-seq, and its altered expression trend was validated by RT-qPCR, with back-splice junction confirmed by RT-PCR and Sanger sequencing."	0.5541
33976984	PeerJ	2021	Identification and comparison of circular RNAs in preeclampsia.	hsa_circ_0008311				Preeclampsia 	MONDO:0005081	preeclampsia	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0008311 was found to be differentially expressed in leukocytes of preeclampsia patients by RNA-seq and its expression change trend was validated in a clinical sample set by RT-qPCR, with junction confirmation via RT-PCR and Sanger sequencing."	0.5541
33976984	PeerJ	2021	Identification and comparison of circular RNAs in preeclampsia.	hsa_circ_0004960				Preeclampsia 	MONDO:0005081	preeclampsia	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0004960 was identified as differentially expressed in leukocytes from preeclampsia patients via RNA-seq, then validated by RT-qPCR in 20 PE vs 20 controls, and its circular junction was confirmed by RT-PCR and Sanger sequencing."	0.5541
33976984	PeerJ	2021	Identification and comparison of circular RNAs in preeclampsia.	hsa_circ_0003753				Preeclampsia 	MONDO:0005081	preeclampsia	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0003753 was identified as differentially expressed in leukocytes from preeclampsia patients using RNA-seq and was experimentally validated by RT-qPCR, with additional confirmation of its back-splice junction via RT-PCR and Sanger sequencing."	0.5541
33976984	PeerJ	2021	Identification and comparison of circular RNAs in preeclampsia.	hsa_circ_0001861				Preeclampsia 	MONDO:0005081	preeclampsia	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0001861 was among the differentially expressed circRNAs in leukocytes of preeclampsia patients identified by RNA-seq and its expression alteration was validated by RT-qPCR, with circular junction verified by RT-PCR and Sanger sequencing."	0.5541
33976984	PeerJ	2021	Identification and comparison of circular RNAs in preeclampsia.	hsa_circ_0006719				Preeclampsia 	MONDO:0005081	preeclampsia	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0006719 showed differential expression in leukocytes from preeclampsia patients in RNA-seq, and this dysregulation trend was validated by RT-qPCR with junction confirmation by RT-PCR and Sanger sequencing."	0.5541
33976984	PeerJ	2021	Identification and comparison of circular RNAs in preeclampsia.	hsa_circ_0005806				Preeclampsia 	MONDO:0005081	preeclampsia	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0005806 was identified as a differentially expressed circRNA in leukocytes from preeclampsia patients through RNA-seq and its altered expression trend was validated by RT-qPCR, with junction confirmed by RT-PCR and Sanger sequencing."	0.5541
33976984	PeerJ	2021	Identification and comparison of circular RNAs in preeclampsia.		circRNA_13301			Preeclampsia 	MONDO:0005081	preeclampsia	up-regulated	RNA-seq	circRNA_13301 was identified as upregulated in leukocytes from preeclampsia patients by RNA-seq and placed into an inferred ceRNA network where it is predicted to sponge four miRNAs and associate with five upregulated mRNAs.	0.1768
33980140	BMC immunology	2021	Circular RNA circFADS2 is overexpressed in sepsis and suppresses LPS-induced lung cell apoptosis by inhibiting the maturation of miR-15a-5p.		circFADS2	hsa_circ_FADS2	FADS2	sepsis	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR	"circFADS2 is up-regulated in sepsis plasma and is induced by LPS in HBEpCs. Its overexpression suppresses LPS-induced apoptosis, at least partly by inhibiting the maturation (and thus reducing the level) of mature miR-15a-5p."	0.5218
33981162	Cancer management and research	2021	CircRNA circ_POLA2 is Upregulated in Acute Myeloid Leukemia (AML) and Promotes Cell Proliferation by Suppressing the Production of Mature miR-34a.		circ_POLA2	hsa_circ_POLA2	POLA2	Acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"circ_POLA2 is upregulated in AML bone marrow samples and AML cell lines, and its high expression is associated with worse overall survival. Functionally, circ_POLA2 promotes AML cell proliferation, at least in part by suppressing the production/maturation of mature miR-34a and increasing PD-L1 expression."	0.6458
33981611	Frontiers in oncology	2021	The circ_0032822 Promotes the Proliferation of Head and Neck Squamous Cell Carcinoma Cells Through miR-141/EF3 Signaling Axis.	hsa_circ_0032822	circ_0032822 		CEP128	Head and neck squamous cell carcinoma 	MONDO:0010150	head and neck squamous cell carcinoma	up-regulated	RT-qPCR	"circ_0032822 is up-regulated in HNSCC tumors and promotes HNSCC cell proliferation, alters cell-cycle distribution (S-phase increase), and inhibits apoptosis. It functions as a ceRNA that sponges miR-141 to de-repress E2F3, supporting tumor growth and associating with worse OS/RFS."	0.8351
33981772	BioMed research international	2021	Circular RNA circPVT1 Contributes to Doxorubicin (DXR) Resistance of Osteosarcoma Cells by Regulating TRIAP1 via miR-137.		circPVT1	hsa_circ_PVT1	PVT1	osteosarcoma	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circPVT1 is up-regulated in osteosarcoma, especially in doxorubicin-resistant tissues/cells, and promotes DXR resistance. Mechanistically, it sponges miR-137 to upregulate TRIAP1, enhancing cell survival/proliferation and reducing apoptosis, and it supports resistant tumor growth in a xenograft model."	0.7045
33982329	Journal of gastroenterology and hepatology	2021	A curcumin analog GL63 inhibits the malignant behaviors of hepatocellular carcinoma by inactivating the JAK2/STAT3 signaling pathway via the circular RNA zinc finger protein 83/microRNA-324-5p/cyclin-dependent kinase 16 axis.	hsa_circ_0052112	circZNF83 	hsa_circ_ZNF83	ZNF83	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circZNF83 is up-regulated in HCC tissues and cell lines and functions as an oncogenic circRNA. It sponges miR-324-5p to increase CDK16 expression and support malignant phenotypes, and GL63 suppresses HCC partly by downregulating circZNF83 to inhibit the miR-324-5p/CDK16 axis and inactivate JAK2/STAT3 signaling."	0.7052
33982351	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2021	Circular RNA circUbe2k promotes hepatic fibrosis via sponging miR-149-5p/TGF-beta2 axis.	mmu_circ_0001350	circUbe2k	mmu_circ_Ube2k	Ube2k	hepatic fibrosis 	MONDO:0100430	fibrotic liver disease	up-regulated	RT-qPCR	"circUbe2k is up-regulated in CCl4-induced hepatic fibrosis and in TGF-beta1-activated LX-2 cells. It promotes hepatic stellate cell activation and proliferation by acting as a ceRNA that sponges miR-149-5p to increase TGF-beta2 expression, and its knockdown alleviates fibrosis phenotypes in vivo and in vitro."	0.8005
33982351	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2021	Circular RNA circUbe2k promotes hepatic fibrosis via sponging miR-149-5p/TGF-beta2 axis.	hsa_circ_0069492	circUbe2k		Ube2k	hepatic fibrosis 	MONDO:0100430	fibrotic liver disease	up-regulated	RT-qPCR	"circUbe2k is up-regulated in CCl4-induced hepatic fibrosis and in TGF-beta1-activated LX-2 cells. It promotes hepatic stellate cell activation and proliferation by acting as a ceRNA that sponges miR-149-5p to increase TGF-beta2 expression, and its knockdown alleviates fibrosis phenotypes in vivo and in vitro."	0.8005
33982667	Aging	2021	Exosomal circRNA 0001445 promotes glioma progression through miRNA-127-5p/SNX5 pathway.		circRNA 0001445 			glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; RNA-seq	"Exosomal circRNA 0001445 is increased in exosome-treated glioma cells and is taken up by recipient cells. It mainly localizes to the cytoplasm and promotes glioma proliferation, migration, and invasion while inhibiting apoptosis by sponging miRNA-127-5p to upregulate SNX5."	0.6174
33982782	Molecular medicine reports	2021	Overexpression of hsa_circ_0001445 reverses oxLDL_induced inhibition of HUVEC proliferation via SRSF1.	hsa_circ_0001445	cSMARCA5	hsa_circ_SMARCA5	SMARCA5	atherosclerosis	MONDO:0005311	atherosclerosis	down-regulated	RT-qPCR	"In an in vitro atherosclerosis model (oxLDL-treated HUVECs), hsa_circ_0001445 is down-regulated, and its overexpression counteracts oxLDL-induced endothelial dysfunction by promoting proliferation and reducing apoptosis and migration. Mechanistically, hsa_circ_0001445 binds the RBP SRSF1 and suppresses beta-catenin/Wnt signaling activity, consistent with an SRSF1/beta-catenin/EMT-related axis."	0.5312
33985545	Molecular cancer	2021	CircMEMO1 modulates the promoter methylation and expression of TCF21 to regulate hepatocellular carcinoma progression and sorafenib treatment sensitivity.	hsa_circ_0006790	circMEMO1	hsa_circ_MEMO1	MEMO1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"circMEMO1 is down-regulated in HCC and acts as a tumor suppressor by inhibiting proliferation, invasion/metastasis and stemness. It sponges miR-106b-5p to restore TET1/2 and 5hmC, promotes TCF21 promoter demethylation and upregulates TCF21, thereby suppressing EMT and improving sensitivity to sorafenib; higher circMEMO1 predicts better survival."	0.8824
33986259	Cell death & disease	2021	Circular RNA circACSL1 aggravated myocardial inflammation and myocardial injury by sponging miR-8055 and regulating MAPK14 expression.	hsa_circ_0071542	circACSL1 	hsa_circ_ACSL1	ACSL1	myocarditis 	MONDO:0004496	myocarditis	up-regulated	RT-qPCR; Microarray	"circACSL1 (hsa_circ_0071542), derived from ACSL1, is upregulated in myocarditis and in LPS-induced inflammatory cardiomyocytes. It promotes myocardial inflammation/injury and apoptosis by sponging miR-8055, thereby derepressing and upregulating MAPK14 (p38alpha), supported by luciferase, pull-down, FISH colocalization and rescue experiments. It may serve as a blood-based biomarker to help diagnose MC and distinguish MC from DCM."	0.8254
33986327	Scientific reports	2021	Thymic transcriptome analysis after Newcastle disease virus inoculation in chickens and the influence of host small RNAs on NDV replication.		ggacirc_023318			Newcastle disease 	MONDO:0005875	Newcastle disease	down-regulated	RNA-seq	ggacirc_023318 was identified as a differentially expressed circRNA (down-regulated at 24 h post LaSota NDV vaccine) in chicken thymus and was bioinformatically predicted (miRanda) to potentially bind gga-miR-6631-5p.	0.1768
33986327	Scientific reports	2021	Thymic transcriptome analysis after Newcastle disease virus inoculation in chickens and the influence of host small RNAs on NDV replication.		ggacirc_013281			Newcastle disease 	MONDO:0005875	Newcastle disease	down-regulated	RNA-seq	ggacirc_013281 was down-regulated at 24 h post LaSota NDV vaccine inoculation in chicken thymus and was predicted by miRanda to potentially bind gga-miR-6631-5p.	0.1768
33986327	Scientific reports	2021	Thymic transcriptome analysis after Newcastle disease virus inoculation in chickens and the influence of host small RNAs on NDV replication.		ggacirc_033324			Newcastle disease 	MONDO:0005875	Newcastle disease	down-regulated	RNA-seq	ggacirc_033324 was down-regulated at 24 h post LaSota NDV vaccine inoculation in chicken thymus and was computationally predicted to potentially bind gga-miR-6631-5p.	0.1768
33986327	Scientific reports	2021	Thymic transcriptome analysis after Newcastle disease virus inoculation in chickens and the influence of host small RNAs on NDV replication.		ggacirc_007720			Newcastle disease 	MONDO:0005875	Newcastle disease	dysregulated	RNA-seq	ggacirc_007720 showed time-dependent dysregulation after LaSota NDV vaccine inoculation (up at 24 h but down at 48 h) and was predicted to potentially bind gga-miR-6631-5p.	0.1768
33986327	Scientific reports	2021	Thymic transcriptome analysis after Newcastle disease virus inoculation in chickens and the influence of host small RNAs on NDV replication.		ggacirc_028880			Newcastle disease 	MONDO:0005875	Newcastle disease	dysregulated	RNA-seq	ggacirc_028880 was time-dependently dysregulated after LaSota NDV vaccine inoculation (up at 24 h but down at 48 h) and was predicted (miRanda) to potentially interact with gga-miR-6631-5p.	0.1768
33986327	Scientific reports	2021	Thymic transcriptome analysis after Newcastle disease virus inoculation in chickens and the influence of host small RNAs on NDV replication.		ggacirc_033375			Newcastle disease 	MONDO:0005875	Newcastle disease	up-regulated	RNA-seq	ggacirc_033375 was up-regulated at 24 h after LaSota NDV vaccine inoculation in chicken thymus and was predicted to potentially bind gga-miR-6631-5p.	0.1768
33986327	Scientific reports	2021	Thymic transcriptome analysis after Newcastle disease virus inoculation in chickens and the influence of host small RNAs on NDV replication.		ggacirc_003001			Newcastle disease 	MONDO:0005875	Newcastle disease	up-regulated	RNA-seq	ggacirc_003001 was up-regulated at 48 h after LaSota NDV vaccine inoculation in chicken thymus and was predicted to potentially bind gga-miR-6631-5p.	0.1768
33986327	Scientific reports	2021	Thymic transcriptome analysis after Newcastle disease virus inoculation in chickens and the influence of host small RNAs on NDV replication.		ggacirc_036392			Newcastle disease 	MONDO:0005875	Newcastle disease	up-regulated	RNA-seq	ggacirc_036392 was up-regulated at 48 h after LaSota NDV vaccine inoculation in chicken thymus and was predicted to potentially bind gga-miR-6631-5p.	0.1768
33986327	Scientific reports	2021	Thymic transcriptome analysis after Newcastle disease virus inoculation in chickens and the influence of host small RNAs on NDV replication.		ggacirc_005990			Newcastle disease 	MONDO:0005875	Newcastle disease	down-regulated	RNA-seq	ggacirc_005990 was down-regulated at 48 h after LaSota NDV vaccine inoculation in chicken thymus and was predicted to potentially bind gga-miR-6631-5p.	0.1768
33986327	Scientific reports	2021	Thymic transcriptome analysis after Newcastle disease virus inoculation in chickens and the influence of host small RNAs on NDV replication.		ggacirc_022025			Newcastle disease 	MONDO:0005875	Newcastle disease	down-regulated	RNA-seq	ggacirc_022025 was down-regulated after LaSota NDV vaccine inoculation (at least at 48 h and 96 h) and was predicted to potentially bind gga-miR-6631-5p.	0.1768
33986327	Scientific reports	2021	Thymic transcriptome analysis after Newcastle disease virus inoculation in chickens and the influence of host small RNAs on NDV replication.		ggacirc_018753			Newcastle disease 	MONDO:0005875	Newcastle disease	up-regulated	RNA-seq	ggacirc_018753 was up-regulated at 48 h after LaSota NDV vaccine inoculation in chicken thymus and was predicted to potentially bind gga-miR-6631-5p.	0.1768
33986327	Scientific reports	2021	Thymic transcriptome analysis after Newcastle disease virus inoculation in chickens and the influence of host small RNAs on NDV replication.		ggacirc_033182			Newcastle disease 	MONDO:0005875	Newcastle disease	down-regulated	RNA-seq	ggacirc_033182 was down-regulated at 48 h after LaSota NDV vaccine inoculation in chicken thymus and was predicted to potentially bind gga-miR-6631-5p.	0.1768
33986327	Scientific reports	2021	Thymic transcriptome analysis after Newcastle disease virus inoculation in chickens and the influence of host small RNAs on NDV replication.		ggacirc_013774			Newcastle disease 	MONDO:0005875	Newcastle disease	up-regulated	RNA-seq	ggacirc_013774 was up-regulated at 72 h after LaSota NDV vaccine inoculation in chicken thymus and was predicted to potentially bind gga-miR-6631-5p.	0.1768
33986327	Scientific reports	2021	Thymic transcriptome analysis after Newcastle disease virus inoculation in chickens and the influence of host small RNAs on NDV replication.		ggacirc_034572			Newcastle disease 	MONDO:0005875	Newcastle disease	down-regulated	RNA-seq	ggacirc_034572 was down-regulated at 96 h after LaSota NDV vaccine inoculation and was predicted to potentially bind gga-miR-6631-5p.	0.1768
33987373	Annals of translational medicine	2021	Ferroptosis is involved in the progression of hepatocellular carcinoma through the circ0097009/miR-1261/SLC7A11 axis.	hsa_circ_0097009	circ0097009	hsa_circ_SLC5A8	SLC5A8	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circ0097009 (hsa_circ_0097009), derived from SLC5A8, is up-regulated in HCC tissues and cell lines and promotes malignant phenotypes (proliferation, invasion, tumor growth and metastasis). Mechanistically, it sponges miR-1261 to de-repress SLC7A11, thereby inhibiting ferroptosis (system Xc- and GPX4-related) and facilitating HCC progression."	0.8442
33987874	Clinical and experimental pharmacology & physiology	2021	The circular RNA circ_GRHPR promotes NSCLC cell proliferation and invasion via interactions with the RNA-binding protein PCBP2.	hsa_circ_0001861	hsa_circ_GRHPR 	hsa_circ_GRHPR	GRHPR	lung cancer 	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; RNA-seq	"circ_GRHPR (hsa_circ_0001861) is upregulated in NSCLC (serum and cell lines) and promotes NSCLC cell proliferation and invasion in vitro and in a xenograft model. Mechanistically, it binds the RBP PCBP2 and shifts PCBP2 toward the cytoplasm, leading to increased nuclear FHL3 expression that contributes to the malignant phenotype."	0.7806
33995497	Frontiers in genetics	2021	"Bioinformatic Analysis of Crosstalk Between circRNA, miRNA, and Target Gene Network in NAFLD."	hsa_circ_0000313				non-alcoholic fatty liver disease 	MONDO:0013209	metabolic dysfunction-associated steatotic liver disease	dysregulated	Microarray	"This study used database predictions and GEO datasets to identify hsa_circ_0000313 as a differentially expressed circRNA in NAFLD and constructed a putative ceRNA crosstalk axis hsa_circ_0000313_hsa-miR-6512-3p_PEG10. The axis was proposed as potentially involved in NAFLD pathogenesis and as a future biomarker candidate, but it lacks experimental validation."	0.1768
33995497	Frontiers in genetics	2021	"Bioinformatic Analysis of Crosstalk Between circRNA, miRNA, and Target Gene Network in NAFLD."	hsa_circ_0001453				non-alcoholic fatty liver disease 	MONDO:0013209	metabolic dysfunction-associated steatotic liver disease	dysregulated	Microarray	This study identified hsa_circ_0001453 as a differentially expressed circRNA in NAFLD via GEO data and built a predicted ceRNA-like axis hsa_circ_0001453_hsa-miR-27b-3p_PEG10. No experimental validation beyond public-dataset verification was provided.	0.1768
33995502	Frontiers in genetics	2021	Detection of circRNA Biomarker for Acute Myocardial Infarction Based on System Biological Analysis of RNA Expression.		circRNA_104761 	hsa_circ_UBAP2	UBAP2	Acute myocardial infarction 	MONDO:0004781	acute myocardial infarction	down-regulated	RT-qPCR; Microarray	circRNA_104761 (host gene UBAP2) is down-regulated in whole blood of AMI patients and decreases under hypoxia in AC16 cardiomyocytes. It shows diagnostic potential (ROC AUC 0.890) and functionally protects cardiomyocytes from hypoxia-induced injury/apoptosis; its mechanism is proposed as miRNA sponging (miR-449/miR-34 family) affecting apoptosis-related pathways such as p53/E2F1.	0.7364
33995502	Frontiers in genetics	2021	Detection of circRNA Biomarker for Acute Myocardial Infarction Based on System Biological Analysis of RNA Expression.		hsa_circRNA068655 	hsa_circ_UBXN7	UBXN7	Acute myocardial infarction 	MONDO:0004781	acute myocardial infarction	down-regulated	RT-qPCR; Microarray	"circRNA_068655 (host gene UBXN7) was identified by microarray and validated by RT-qPCR as down-regulated in whole blood of AMI patients versus mild coronary artery stenosis controls. It was proposed as a potential AMI biomarker, with predicted miRNA binding partners from TargetScan/miRanda."	0.5135
33995502	Frontiers in genetics	2021	Detection of circRNA Biomarker for Acute Myocardial Infarction Based on System Biological Analysis of RNA Expression.		circRNA_104765	hsa_circ_UBAP2	UBAP2	Acute myocardial infarction 	MONDO:0004781	acute myocardial infarction	down-regulated	RT-qPCR; Microarray	"circRNA_104765 (host gene UBAP2) was identified by microarray and validated by RT-qPCR as down-regulated in whole blood of AMI patients versus mild coronary artery stenosis controls. It was proposed as a potential AMI biomarker, with predicted miRNA binding partners from TargetScan/miRanda."	0.5135
33995660	Theranostics	2021	CircUbe3a from M2 macrophage-derived small extracellular vesicles mediates myocardial fibrosis after acute myocardial infarction.	mmu_circ_0001572	CircUbe3a 	mmu_circ_Ube3a	Ube3a	acute myocardial infarction 	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR; Microarray	"In a mouse AMI model, circUbe3a is enriched in M2 macrophage-derived small extracellular vesicles and transferred to cardiac fibroblasts. It promotes fibroblast proliferation, migration and myofibroblastic transformation, exacerbating post-AMI myocardial fibrosis by sponging miR-138-5p and thereby regulating RhoC."	0.7887
33996428	Journal of bone oncology	2021	Hsa_circ_0010220 regulates miR-198/Syntaxin 6 axis to promote osteosarcoma progression.	hsa_circ_0010220	circ_0010220	hsa_circ_ARHGEF10L	ARHGEF10L	osteosarcoma	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"circ_0010220 (from ARHGEF10L) is up-regulated in osteosarcoma tissues/cells and its high expression is linked to poorer survival. Functionally, circ_0010220 promotes malignant phenotypes and xenograft growth by sponging miR-198 to derepress STX6, forming a circ_0010220/miR-198/STX6 ceRNA axis."	0.8621
33996547	Frontiers in oncology	2021	circATP2B1 Promotes Aerobic Glycolysis in Gastric Cancer Cells Through Regulation of the miR-326 Gene Cluster.	hsa_circ_0000826	circATP2B1 	hsa_circ_ATP2B1	ATP2B1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circATP2B1 is up-regulated in gastric cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes aerobic glycolysis and proliferation by sponging miR-326-3p/miR-330-5p (miR-326 gene cluster) in an Ago2/RISC-dependent manner, thereby relieving repression of PKM2."	0.8606
33996813	Frontiers in cell and developmental biology	2021	circDENND1B Participates in the Antiatherosclerotic Effect of IL-1beta Monoclonal Antibody in Mouse by Promoting Cholesterol Efflux via miR-17-5p/Abca1 Axis.	mmu_circ_0000081	circDENND1B	mmu_circ_DENND1B	Dennd1b	atherosclerosis 	MONDO:0005311	atherosclerosis	down-regulated	RT-qPCR; RNA-seq	"In ApoE_/_ atherosclerotic mice and ox-LDL-induced macrophage foam cells, circDENND1B is down-regulated and its upregulation reduces foam cell formation by promoting cholesterol efflux. Mechanistically, circDENND1B acts as a cytoplasmic ceRNA that sponges miR-17-5p to increase Abca1 expression, contributing to the anti-atherosclerotic effect of IL-1beta monoclonal antibody."	0.8017
33999949	PLoS pathogens	2021	Characterization of ALTO-encoding circular RNAs expressed by Merkel cell polyomavirus and trichodysplasia spinulosa polyomavirus.		circALTO1		ALTO	Merkel cell carcinoma 	MONDO:0019210	cutaneous neuroendocrine carcinoma	unknown	RT-qPCR; Northern Blot; RNA-seq	"MCPyV circALTO1 is a viral circRNA from the ALTO region that can be translated to ALTO protein in cultured cells. ALTO acts as a transcriptional enhancer for specific promoters and is negatively regulated by MCPyV miRNAs. circALTO RNAs are stable, mainly cytoplasmic, and can be packaged into exosomes to mediate ALTO expression in recipient cells."	0.7938
33999949	PLoS pathogens	2021	Characterization of ALTO-encoding circular RNAs expressed by Merkel cell polyomavirus and trichodysplasia spinulosa polyomavirus.		circALTO2		ALTO	Merkel cell carcinoma 	MONDO:0019210	cutaneous neuroendocrine carcinoma	dysregulated	RT-qPCR; Northern Blot; RNA-seq	"MCPyV circALTO2 is a viral circRNA detected in virus-positive MCC tumors/cell lines, resistant to RNase R, and confirmed by sequencing/Northern blot. It localizes mainly to the cytoplasm, is m6A-modified, and serves as a template to translate ALTO protein, whose expression can be suppressed by MCPyV miRNAs. circALTO2 is enriched in exosomes and can be transferred to recipient cells to drive ALTO expression and transcriptional activation."	0.8108
33999949	PLoS pathogens	2021	Characterization of ALTO-encoding circular RNAs expressed by Merkel cell polyomavirus and trichodysplasia spinulosa polyomavirus.		TSPyV circALTO		ALTO	trichodysplasia spinulosa 	MONDO:0016455	virus-associated trichodysplasia spinulosa	unknown	RT-qPCR	"TSPyV circALTO is a viral circRNA detectable in a subset of trichodysplasia spinulosa patient skin biopsies, confirmed by RNase R resistance and Sanger sequencing of the backsplice junction. In vitro transfection shows it can be translated to TSPyV ALTO protein, but unlike MCPyV ALTO it did not activate tested GFP reporter promoters."	0.5862
34001137	Cancer cell international	2021	Circular RNA circHECTD1 prevents Diosbulbin-B-sensitivity via miR-137/PBX3 axis in gastric cancer.	hsa_circ_0031452	circHECTD1	hsa_circ_HECTD1	HECTD1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circHECTD1 (hsa_circ_0031452) is up-regulated in gastric cancer tissues and cell lines and promotes tumor growth. Mechanistically, it sponges miR-137 to upregulate PBX3, thereby increasing Diosbulbin-B resistance (reducing DB sensitivity) by affecting cell viability, cell-cycle arrest, and apoptosis."	0.7092
34002672	Bioengineered	2021	Circular RNA circ_0008274 upregulates granulin to promote the progression of hepatocellular carcinoma via sponging microRNA -140-3p.	hsa_circ_0008274	circ_0008274 	hsa_circ_UGGT2	UGGT2	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0008274 is up-regulated in hepatocellular carcinoma and mainly localizes to the cytoplasm. It promotes HCC cell proliferation, migration and invasion by sponging miR-140-3p, thereby relieving repression of GRN and increasing GRN expression."	0.7283
34004360	"Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases"	2021	Differential host circRNA expression profiles in human lung epithelial cells infected with SARS-CoV-2.	hsa_circ_0000566		hsa_circ_VRK1	VRK1	SARS-CoV-2 infection 	MONDO:0100096	COVID-19	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0000566 is a SARS-CoV-2 infection_associated dysregulated host circRNA validated by RT-qPCR in BEAS-2B cells after RNA-seq discovery in Calu-3. It is predicted to bind RBPs including AGO2, EIF4A3, HuR and U2AF65, suggesting potential involvement in post-transcriptional regulation during antiviral responses."	0.4032
34004360	"Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases"	2021	Differential host circRNA expression profiles in human lung epithelial cells infected with SARS-CoV-2.	hsa_circ_0060927				SARS-CoV-2 infection 	MONDO:0100096	COVID-19	dysregulated	RT-qPCR; RNA-seq	hsa_circ_0060927 is among the top significantly dysregulated circRNAs during SARS-CoV-2 infection and was included in the constructed circRNA_miRNA_gene (ceRNA) network. It was also selected for RT-qPCR validation of expression changes in BEAS-2B cells.	0.2465
34004360	"Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases"	2021	Differential host circRNA expression profiles in human lung epithelial cells infected with SARS-CoV-2.	hsa_circ_0067985		hsa_circ_FNDC3B	FNDC3B	SARS-CoV-2 infection 	MONDO:0100096	COVID-19	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0067985 (host gene FNDC3B) is a dysregulated host circRNA in SARS-CoV-2-infected lung epithelial cells, validated by RT-qPCR and included in the ceRNA network analysis. It is also predicted to bind RBPs EIF4A3 and HuR, suggesting potential roles in post-transcriptional regulation during infection."	0.2465
34004360	"Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases"	2021	Differential host circRNA expression profiles in human lung epithelial cells infected with SARS-CoV-2.		circRNA_04769			SARS-CoV-2 infection 	MONDO:0100096	COVID-19	dysregulated	RT-qPCR; RNA-seq	"circRNA_04769 is a dysregulated circRNA during SARS-CoV-2 infection identified by RNA-seq and selected for RT-qPCR validation in BEAS-2B cells. The paper does not provide its host gene, mechanism, or interaction partners in the provided text."	0.1904
34004360	"Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases"	2021	Differential host circRNA expression profiles in human lung epithelial cells infected with SARS-CoV-2.	hsa_circ_0001681		hsa_circ_RAPGEF5	RAPGEF5	SARS-CoV-2 infection 	MONDO:0100096	COVID-19	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0001681 (host gene RAPGEF5) is a dysregulated circRNA during SARS-CoV-2 infection validated by RT-qPCR and included in the ceRNA network analysis. It is predicted to interact with EIF4A3 and FUS, implying a potential role via RBP binding and RNA-level regulation during infection."	0.2465
34004360	"Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases"	2021	Differential host circRNA expression profiles in human lung epithelial cells infected with SARS-CoV-2.	hsa_circ_0080941		hsa_circ_PCLO	PCLO	SARS-CoV-2 infection 	MONDO:0100096	COVID-19	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0080941 (host gene PCLO) is a significantly dysregulated circRNA in SARS-CoV-2-infected lung epithelial cells, validated by RT-qPCR and incorporated into the ceRNA network. It is predicted to bind EIF4A3, suggesting potential regulation through RBP-associated post-transcriptional processes during infection."	0.2465
34004360	"Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases"	2021	Differential host circRNA expression profiles in human lung epithelial cells infected with SARS-CoV-2.	hsa_circ_0080942		hsa_circ_PCLO	PCLO	SARS-CoV-2 infection 	MONDO:0100096	COVID-19	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0080942 (host gene PCLO) is a significantly dysregulated circRNA in SARS-CoV-2-infected lung epithelial cells, validated by RT-qPCR and included in ceRNA network analysis. It is predicted to bind EIF4A3 and FUS, suggesting possible roles through RBP-associated regulation during infection."	0.2465
34004360	"Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases"	2021	Differential host circRNA expression profiles in human lung epithelial cells infected with SARS-CoV-2.	hsa_circ_0005630		hsa_circ_RAB11FIP1	RAB11FIP1	SARS-CoV-2 infection 	MONDO:0100096	COVID-19	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0005630 (host gene RAB11FIP1) is a significantly dysregulated circRNA in SARS-CoV-2-infected lung epithelial cells, validated by RT-qPCR and incorporated into a ceRNA network analysis. It is predicted to bind EIF4A3, suggesting possible involvement in RBP-related post-transcriptional regulation during infection."	0.2465
34007212	Cancer management and research	2021	Depletion of Circular RNA circ_CORO1C Suppresses Gastric Cancer Development by Modulating miR-138-5p/KLF12 Axis.	hsa_circ_0000437	circ_CORO1C 	hsa_circ_CORO1C	CORO1C	Gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_CORO1C is up-regulated in gastric cancer tissues and cell lines and functions as an oncogenic circRNA. Its knockdown suppresses proliferation, migration, invasion and EMT while promoting apoptosis, and inhibits tumor growth in a xenograft model by sponging miR-138-5p to upregulate KLF12."	0.7416
34007215	Cancer management and research	2021	"Circ_HIPK3 Knockdown Inhibits Cell Proliferation, Migration and Invasion of Cholangiocarcinoma Partly via Mediating the miR-148a-3p/ULK1 Pathway."		circ_HIPK3 	hsa_circ_HIPK3	HIPK3	cholangiocarcinoma 	MONDO:0019087	cholangiocarcinoma	up-regulated	RT-qPCR	"circ_HIPK3 is up-regulated in cholangiocarcinoma and functions as an oncogenic circRNA. Its knockdown suppresses proliferation, colony formation, migration/invasion and tumor growth while promoting apoptosis and G0/G1 arrest, partly by sponging miR-148a-3p to upregulate ULK1."	0.6973
34012268	OncoTargets and therapy	2021	Inhibition of circRNA circVPS33B Reduces Warburg Effect and Tumor Growth Through Regulating the miR-873-5p/HNRNPK Axis in Infiltrative Gastric Cancer.	hsa_circ_0005529	circVPS33B 	hsa_circ_VPS33B	VPS33B	infiltrative gastric cancer 	MONDO:0001060	microinvasive gastric cancer	up-regulated	RT-qPCR	"circVPS33B is up-regulated in infiltrative gastric cancer tissues/cells and promotes malignant behaviors and the Warburg effect. It functions mainly in the cytoplasm as a ceRNA, sponging miR-873-5p to increase HNRNPK expression, thereby enhancing tumor growth in vitro and in a xenograft model."	0.8442
34012271	OncoTargets and therapy	2021	CircHIPK2 Contributes to DDP Resistance and Malignant Behaviors of DDP-Resistant Ovarian Cancer Cells Both in vitro and in vivo Through circHIPK2/miR-338-3p/CHTOP ceRNA Pathway.	hsa_circ_0001756	circHIPK2 	hsa_circ_HIPK2	HIPK2	ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circHIPK2 is up-regulated in DDP-resistant ovarian cancer tissues and cells and promotes cisplatin resistance and malignant phenotypes. It acts as a ceRNA by sponging miR-338-3p to increase CHTOP expression, thereby enhancing proliferation/cell-cycle progression, migration/invasion and reducing apoptosis; silencing circHIPK2 suppresses tumor growth in xenografts."	0.7983
34012513	Oncotarget	2021	Transcriptome analyses of urine RNA reveal tumor markers for human bladder cancer: validated amplicons for RT-qPCR-based detection.	hsa_circ_0084758		hsa_circ_TRAM1	TRAM1	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RNA-seq	Circular TRAM1 circRNAs (hsa_circ_0084756/57/58/59) are reduced in urine from high risk bladder cancer patients versus controls based on RNA-seq. The study proposes them as non-invasive urine RNA tumor markers and suggests combining with S100A6 as a ratio for better discrimination.	0.3858
34012513	Oncotarget	2021	Transcriptome analyses of urine RNA reveal tumor markers for human bladder cancer: validated amplicons for RT-qPCR-based detection.	hsa_circ_0084756		hsa_circ_TRAM1	TRAM1	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RNA-seq	Circular TRAM1 circRNAs (hsa_circ_0084756/57/58/59) are reduced in urine from high risk bladder cancer patients versus controls based on RNA-seq. The study proposes them as non-invasive urine RNA tumor markers and suggests combining with S100A6 as a ratio for better discrimination.	0.3858
34012513	Oncotarget	2021	Transcriptome analyses of urine RNA reveal tumor markers for human bladder cancer: validated amplicons for RT-qPCR-based detection.	hsa_circ_0084757		hsa_circ_TRAM1	TRAM1	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RNA-seq	Circular TRAM1 circRNAs (hsa_circ_0084756/57/58/59) are reduced in urine from high risk bladder cancer patients versus controls based on RNA-seq. The study proposes them as non-invasive urine RNA tumor markers and suggests combining with S100A6 as a ratio for better discrimination.	0.3858
34012513	Oncotarget	2021	Transcriptome analyses of urine RNA reveal tumor markers for human bladder cancer: validated amplicons for RT-qPCR-based detection.	hsa_circ_0084759		hsa_circ_TRAM1	TRAM1	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RNA-seq	Circular TRAM1 circRNAs (hsa_circ_0084756/57/58/59) are reduced in urine from high risk bladder cancer patients versus controls based on RNA-seq. The study proposes them as non-invasive urine RNA tumor markers and suggests combining with S100A6 as a ratio for better discrimination.	0.3858
34012513	Oncotarget	2021	Transcriptome analyses of urine RNA reveal tumor markers for human bladder cancer: validated amplicons for RT-qPCR-based detection.	hsa_circ_0014225		hsa_circ_S100A6	S100A6	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RNA-seq	Circular S100A6 circRNAs (hsa_circ_0014224/25/26/27) are increased in urine from high risk bladder cancer patients versus controls based on RNA-seq. The study proposes them as urine RNA tumor markers and highlights the diagnostic potential of the S100A6/TRAM1 ratio.	0.3858
34012513	Oncotarget	2021	Transcriptome analyses of urine RNA reveal tumor markers for human bladder cancer: validated amplicons for RT-qPCR-based detection.	hsa_circ_0014226		hsa_circ_S100A6	S100A6	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RNA-seq	Circular S100A6 circRNAs (hsa_circ_0014224/25/26/27) are increased in urine from high risk bladder cancer patients versus controls based on RNA-seq. The study proposes them as urine RNA tumor markers and highlights the diagnostic potential of the S100A6/TRAM1 ratio.	0.3858
34012513	Oncotarget	2021	Transcriptome analyses of urine RNA reveal tumor markers for human bladder cancer: validated amplicons for RT-qPCR-based detection.	hsa_circ_0014224		hsa_circ_S100A6	S100A6	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RNA-seq	Circular S100A6 circRNAs (hsa_circ_0014224/25/26/27) are increased in urine from high risk bladder cancer patients versus controls based on RNA-seq. The study proposes them as urine RNA tumor markers and highlights the diagnostic potential of the S100A6/TRAM1 ratio.	0.3858
34012513	Oncotarget	2021	Transcriptome analyses of urine RNA reveal tumor markers for human bladder cancer: validated amplicons for RT-qPCR-based detection.	hsa_circ_0014227		hsa_circ_S100A6	S100A6	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RNA-seq	Circular S100A6 circRNAs (hsa_circ_0014224/25/26/27) are increased in urine from high risk bladder cancer patients versus controls based on RNA-seq. The study proposes them as urine RNA tumor markers and highlights the diagnostic potential of the S100A6/TRAM1 ratio.	0.3858
34012794	Translational lung cancer research	2021	"Role of the epithelial-mesenchymal transition-related circular RNA, circ-10720, in non-small-cell lung cancer."	hsa_circ_0018189	circ-10720	hsa_circ_CUL2	CUL2	non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ-10720 (hsa_circ_0018189, host gene CUL2) is upregulated in NSCLC tumor tissue and promotes EMT-associated phenotypes. Its knockdown reduces VIM protein, suppresses migration/invasion, increases apoptosis, and decreases proliferation; high tumor expression predicts shorter time to relapse in non-adjuvantly treated resected patients, with evidence consistent with a miR-1246-mediated ceRNA mechanism."	0.6211
34012964	Frontiers in cell and developmental biology	2021	Circular RNA Circ0021205 Promotes Cholangiocarcinoma Progression Through MiR-204-5p/RAB22A Axis.	hsa_circ_0021205	Circ0021205 			Cholangiocarcinoma 	MONDO:0019087	cholangiocarcinoma	up-regulated	RT-qPCR	"circ_0021205 is up-regulated in cholangiocarcinoma and promotes malignant phenotypes (proliferation, migration, invasion) and xenograft tumor growth. Mechanistically, it acts as a ceRNA by sponging miR-204-5p to increase RAB22A expression, supporting a circ_0021205/miR-204-5p/RAB22A axis and potential diagnostic/therapeutic relevance."	0.7412
34013042	"Open medicine (Warsaw, Poland)"	2021	circAGFG1 sponges miR-28-5p to promote non-small-cell lung cancer progression through modulating HIF-1alpha level.			hsa_circ_AGFG1	AGFG1	non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circAGFG1 is up-regulated in NSCLC tissues and serum and is associated with poor overall survival. Functionally, circAGFG1 promotes NSCLC cell proliferation, migration, invasion, glycolysis and tumor growth while inhibiting apoptosis, mainly by sponging miR-28-5p to increase HIF-1alpha."	0.8198
34015763	Aging	2021	Circular RNA ITCH promotes extracellular matrix degradation via activating Wnt/beta-catenin signaling in intervertebral disc degeneration.		circITCH 	hsa_circ_ITCH	ITCH	intervertebral disc degeneration 	MONDO:0011385	intervertebral disk degenerative disorder	up-regulated	RT-qPCR	"circITCH is up-regulated in IDD nucleus pulposus tissues and promotes NP-cell apoptosis, suppresses proliferation, and accelerates ECM degradation. Mechanistically, circITCH sponges miR-17-5p to increase SOX4 and activate Wnt/beta-catenin signaling, driving degenerative changes."	0.6479
34015764	Aging	2021	Circular RNA ABCB10 contributes to laryngeal squamous cell carcinoma (LSCC) progression by modulating the miR-588/CXCR4 axis.		circular RNA ABCB10 	hsa_circ_ABCB10	ABCB10	laryngeal squamous cell carcinoma 	MONDO:0005595	laryngeal squamous cell carcinoma	unknown	RT-qPCR	"circABCB10 promotes LSCC malignant behaviors (proliferation, migration/invasion and tumor growth) and inhibits apoptosis. Mechanistically, it sponges miR-588, thereby increasing CXCR4 expression; CXCR4 overexpression or miR-588 inhibition rescues the effects of circABCB10 knockdown."	0.5312
34017919	Open life sciences	2021	Downregulation of circ_0037655 impedes glioma formation and metastasis via the regulation of miR-1229-3p/ITGB8 axis.	hsa_circ_0037655	circ_0037655	hsa_circ_CREBBP	CREBBP	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ_0037655 is up-regulated in glioma tissues and cell lines and functions as an oncogenic circRNA. It sponges miR-1229-3p to increase ITGB8 expression, thereby promoting proliferation, cell-cycle progression, migration/invasion, EMT, and in vivo tumor growth; circ_0037655 knockdown reverses these phenotypes."	0.6973
34020619	BMC cancer	2021	Hsa_circ_0000301 facilitates the progression of cervical cancer by targeting miR-1228-3p/IRF4 Axis.	hsa_circ_0000301		hsa_circ_SPL1	SPL1	cervical cancer 	MONDO:0002974	cervical cancer	dysregulated	Microarray	"This study identified hsa_circ_0000301 as the sole core DE-circRNA from GSE102686 and constructed a circRNA-miRNA-mRNA network in cervical cancer. Bioinformatic predictions support a putative ceRNA axis involving hsa_circ_0000301, hsa-miR-1228-3p, and IRF4 (and additional axes with CXCL16, OAS3, PTGER3), suggesting involvement in cervical cancer development."	0.1768
34020639	Cancer cell international	2021	Circ_0000745 strengthens the expression of CCND1 by functioning as miR-488 sponge and interacting with HuR binding protein to facilitate the development of oral squamous cell carcinoma.	hsa_circ_0000745	circ_0000745 			oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circ_0000745 is up-regulated in OSCC tissues/cell lines and promotes malignant phenotypes. It enhances CCND1 expression by sponging miR-488 and by binding the RBP HuR to facilitate CCND1 mRNA stability/interaction, thereby promoting proliferation and cell-cycle progression while suppressing apoptosis; high expression correlates with worse overall survival."	0.82
34022910	Cancer cell international	2021	Circular RNA circ_0006168 enhances Taxol resistance in esophageal squamous cell carcinoma by regulating miR-194-5p/JMJD1C axis.	hsa_circ_0006168	circ_0006168	hsa_circ_CNOT6L	CNOT6L	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"circ_0006168 is up-regulated in ESCC tissues/cells and further elevated in Taxol-resistant ESCC cells. It promotes Taxol resistance and malignant phenotypes by sponging miR-194-5p to upregulate JMJD1C, and its knockdown increases Taxol sensitivity and suppresses xenograft tumor growth."	0.7794
34024242	Annals of medicine	2021	"Circular RNA circ_0010235 sponges miR-338-3p to play oncogenic role in proliferation, migration and invasion of non-small-cell lung cancer cells through modulating KIF2A."	hsa_circ_0010235	circ_0010235	hsa_circ_ALDH4A1	ALDH4A1	non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0010235 is upregulated in NSCLC tissues and cell lines and functions as an oncogenic circRNA. Its knockdown suppresses proliferation, migration/invasion and tumour growth while promoting apoptosis, mainly via the circ_0010235_miR-338-3p_KIF2A ceRNA axis and associated EMT marker changes (E-cadherin/N-cadherin)."	0.7983
34027234	Bioactive materials	2021	Small extracellular vesicles in combination with sleep-related circRNA3503: A targeted therapeutic agent with injectable thermosensitive hydrogel to prevent osteoarthritis.		circRNA3503 	hsa_circ_ZNF430	ZNF430	osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR; RNA-seq	"circRNA3503 is down-regulated in inflammation-induced OA-like chondrocytes (TNF-alpha/IL-1beta) and its overexpression counteracts IL-1beta-induced apoptosis and ECM catabolism. It functions mainly through a ceRNA mechanism by sponging hsa-miR-181c-3p and hsa-let-7b-3p to increase PGC-1alpha (PPARGC1A) and SOX9, helping restore cartilage homeostasis and enabling a therapeutic strategy using circRNA3503-loaded SMSC-derived sEVs (with PLEL hydrogel delivery) to prevent OA progression."	0.7799
34028890	Journal of clinical laboratory analysis	2021	Circular RNA hsa_circ_0001874 is an indicator for gastric cancer.	hsa_circ_0001874		hsa_circ_BICD2	BICD2	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0001874 is down-regulated in gastric cancer tissues and GC cell lines and is proposed as a diagnostic indicator (AUC 0.673). Bioinformatics predicts it acts as a miRNA sponge for miR-593-5p, miR-103a-3p and miR-107, potentially influencing cell cycle-, p53 signaling- and metabolism-related processes via downstream target genes."	0.5963
34031947	The journal of gene medicine	2021	Hsa_circRNA_102229 facilitates the progression of triple-negative breast cancer via regulating the miR-152-3p/PFTK1 pathway.		hsa_circRNA_102229 	hsa_circ_NPLOC4	NPLOC4	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"hsa_circRNA_102229 (hsa_circ_102229) is up-regulated in TNBC and promotes proliferation, migration, invasion and metastasis while inhibiting apoptosis. Mechanistically, it acts as a ceRNA that sponges miR-152-3p to increase PFTK1 expression, and high expression is associated with poor prognosis in TNBC patients."	0.8192
34032607	Aging	2021	Hsa_circ_0032131 knockdown inhibits osteoarthritis progression via the miR-502-5p/PRDX3 axis.	hsa_circ_0032131				osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"hsa_circ_0032131 is upregulated in osteoarthritis models and promotes OA-related chondrocyte injury. Its knockdown alleviates apoptosis and restores proliferation partly by acting as a ceRNA that sponges miR-502-5p to modulate PRDX3, affecting Trx1 and STAT3 signaling and improving OA phenotypes in vivo."	0.6006
34034740	Cancer cell international	2021	circ-PTK2 (hsa_circ_0008305) regulates the pathogenic processes of ovarian cancer via miR-639 and FOXC1 regulatory cascade.	hsa_circ_0008305	circ-PTK2 	hsa_circ_PTK2	PTK2	ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circ-PTK2 (hsa_circ_0008305) is up-regulated in ovarian cancer tissues and promotes ovarian cancer progression by enhancing migration, invasion, angiogenesis, EMT and in vivo tumor growth. Mechanistically, circ-PTK2 acts as a ceRNA by binding miR-639, thereby relieving miR-639-mediated repression of FOXC1."	0.8256
34035217	Cell death & disease	2021	"Circ_0001367 inhibits glioma proliferation, migration and invasion by sponging miR-431 and thus regulating NRXN3."	hsa_circ_0001367	circ_0001367	hsa_circ_KLHL24	KLHL24	glioma 	MONDO:0021042	glioma	down-regulated	RT-qPCR; ISH	"circ_0001367 is down-regulated in glioma tissues and cell lines and acts as a tumor suppressor. It inhibits glioma proliferation, migration and invasion (and tumor growth in vivo) by sponging miR-431 to relieve repression of NRXN3, forming a circ_0001367/miR-431/NRXN3 ceRNA axis. Low circ_0001367 expression is associated with worse patient outcome."	0.8353
34035858	Experimental and therapeutic medicine	2021	circSKIL promotes the ossification of cervical posterior longitudinal ligament by activating the JNK/STAT3 pathway.		circSKIL 	hsa_circ_SKI		ossification of the posterior longitudinal ligament 	MONDO:0011230	ossification of the posterior longitudinal ligament of the spine	up-regulated	RT-qPCR	"circSKIL is up-regulated in OPLL posterior longitudinal ligament cells/tissues and promotes ligament-cell proliferation, mineralization, and osteogenic differentiation. Mechanistically, circSKIL activates the JNK/STAT3 signaling axis (increased JNK and STAT3 phosphorylation), while circSKIL knockdown suppresses these processes."	0.5358
34036610	Journal of applied toxicology : JAT	2022	Potential role of circular RNA in cyclosporin A-induced cardiotoxicity in rats.		rno_circRNA_014540	rno_circ_Prepl	Prepl	CsA-induced cardiotoxicity 	MONDO:0029000	poisoning	up-regulated	RT-qPCR; Microarray	"rno_circRNA_014540 is up-regulated in rat hearts with CsA-induced cardiotoxicity and was validated by qRT-PCR. The study predicts it may sponge miR-329-5p/miR-376c-3p/miR-877, potentially linking circRNA dysregulation to autophagy/apoptosis-related mechanisms in CsA cardiotoxicity."	0.5922
34036610	Journal of applied toxicology : JAT	2022	Potential role of circular RNA in cyclosporin A-induced cardiotoxicity in rats.		rno_circRNA_003481	rno_circ_Pan3	Pan3	CsA-induced cardiotoxicity 	MONDO:0029000	poisoning	down-regulated	RT-qPCR; Microarray	"rno_circRNA_003481 is down-regulated in rat hearts with CsA-induced cardiotoxicity and was validated by qRT-PCR. The study predicts it may bind miR-667-5p/miR-135b-5p/miR-133c, supporting a possible miRNA-sponge role for circRNAs in CsA cardiotoxicity."	0.5922
34036683	Cancer science	2021	Heparanase confers temozolomide resistance by regulation of exosome secretion and circular RNA composition in glioma.	hsa_circ_0042003		hsa_circ_CTC1	CTC1	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR; Microarray	Exosomal hsa_circ_0042003 is elevated in TMZ-resistant glioma models and in serum exosomes from TMZ-nonresponders. Its transfer via exosomes promotes TMZ chemoresistance by increasing proliferation and reducing apoptosis; silencing it in exosomes restores TMZ sensitivity in vitro and suppresses xenograft growth in vivo.	0.7173
34040392	OncoTargets and therapy	2021	Circular RNA circWDR27 Promotes Papillary Thyroid Cancer Progression by Regulating miR-215-5p/TRIM44 Axis.	hsa_circ_0078738	circWDR27 	hsa_circ_WDR27	WDR27	papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circWDR27 is up-regulated in papillary thyroid cancer tissues/cells and functions as an oncogenic circRNA. It promotes proliferation and metastatic behaviors by sponging miR-215-5p to increase TRIM44 expression, and its knockdown suppresses xenograft tumor growth."	0.6745
34040437	Cancer management and research	2021	Circ_0001944 Contributes to Glycolysis and Tumor Growth by Upregulating NFAT5 Through Acting as a Decoy for miR-142-5p in Non-Small Cell Lung Cancer.	hsa_circ_0001944	circ_0001944			non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0001944 is up-regulated in NSCLC and promotes malignant phenotypes and glycolysis. Mechanistically, it acts as a sponge/decoy for miR-142-5p to relieve repression of NFAT5, leading to increased glycolysis-related markers (HK2, LDHA) and enhanced tumor growth in vitro and in vivo."	0.7548
34043680	PloS one	2021	Knockdown of hsa_circ_0001275 reverses dexamethasone-induced osteoblast growth inhibition via mediation of miR-377/CDKN1B axis.	hsa_circ_0001275				osteoporosis	MONDO:0005298	osteoporosis	up-regulated	RT-qPCR	"In DEX-treated human osteoblast hFOB1.19 cells (an in vitro osteoporosis model), hsa_circ_0001275 is induced and contributes to growth inhibition, apoptosis, and mineralization changes. Silencing hsa_circ_0001275 alleviates these effects by sponging miR-377 and regulating the downstream target CDKN1B, affecting G1 arrest-related proteins (CDK2 and Cyclin E1)."	0.6278
34045869	OncoTargets and therapy	2021	Sevoflurane Suppresses Colon Cancer Cell Malignancy by Regulating circ-PI4KA.	hsa_circ_0062389	circ-PI4KA 	hsa_circ_PI4KA	PI4KA	colon cancer	MONDO:0021063	malignant colon neoplasm	up-regulated	RT-qPCR; Microarray	"circ-PI4KA is up-regulated in colon cancer and functions as an oncogenic circRNA. It sponges miR-331-3p to increase LASP1, promoting proliferation/migration/invasion and reducing apoptosis, thereby counteracting sevoflurane-induced suppression of malignancy and affecting tumor growth in vivo."	0.786
34046827	Molecular and cellular biochemistry	2021	Circ_0020093 ameliorates IL-1beta-induced apoptosis and extracellular matrix degradation of human chondrocytes by upregulating SPRY1 via targeting miR-23b.	hsa_circ_0020093	circ_0020093	hsa_circ_ATRNL1	ATRNL1	Osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR	"In an IL-1beta-induced osteoarthritis-like human chondrocyte model, circ_0020093 is down-regulated and functions protectively by reducing apoptosis and extracellular matrix degradation. Mechanistically, circ_0020093 sponges miR-23b to relieve repression of SPRY1, forming a circ_0020093/miR-23b/SPRY1 axis."	0.6089
34049561	Journal of translational medicine	2021	Identification of circRNA-miRNA-mRNA networks contributes to explore underlying pathogenesis and therapy strategy of gastric cancer.	hsa_circ_0000390		hsa_circ_FGD4	FGD4	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; RNA-seq; Microarray	hsa_circ_0000390 is down-regulated in gastric cancer tissues and is predominantly localized in the cytoplasm. The study suggests it may act as a ceRNA by sponging miRNAs (with predicted MREs and AGO2 binding) within circRNA_miRNA_mRNA networks that relate to MAPK and PI3K-AKT pathway-enriched target genes.	0.6223
34049561	Journal of translational medicine	2021	Identification of circRNA-miRNA-mRNA networks contributes to explore underlying pathogenesis and therapy strategy of gastric cancer.	hsa_circ_0000615		hsa_circ_ZNF609	ZNF609	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; RNA-seq; Microarray	hsa_circ_0000615 is down-regulated in gastric cancer tissues and is mainly localized in the cytoplasm. It is proposed to act in circRNA_miRNA_mRNA ceRNA networks (with predicted MREs/AGO2 binding) that are linked to MAPK and PI3K-AKT enriched target genes.	0.6223
34049561	Journal of translational medicine	2021	Identification of circRNA-miRNA-mRNA networks contributes to explore underlying pathogenesis and therapy strategy of gastric cancer.	hsa_circ_0001438		hsa_circ_LARP1B	LARP1B	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; RNA-seq; Microarray	hsa_circ_0001438 is down-regulated in gastric cancer and predominantly localized in the cytoplasm. The study supports a proposed ceRNA role through predicted miRNA binding (with AGO2 binding site evidence) within circRNA_miRNA_mRNA networks enriched for MAPK and PI3K-AKT pathways.	0.6223
34049561	Journal of translational medicine	2021	Identification of circRNA-miRNA-mRNA networks contributes to explore underlying pathogenesis and therapy strategy of gastric cancer.	hsa_circ_0002190		hsa_circ_KLHDC10	KLHDC10	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; RNA-seq; Microarray	"hsa_circ_0002190 is down-regulated in gastric cancer tissues and mainly localizes to the cytoplasm. The study places it in predicted ceRNA networks (circRNA_miRNA_mRNA) supported by MRE prediction and AGO2 binding-site mining, with downstream genes enriched in MAPK and PI3K-AKT pathways."	0.6223
34049561	Journal of translational medicine	2021	Identification of circRNA-miRNA-mRNA networks contributes to explore underlying pathogenesis and therapy strategy of gastric cancer.	hsa_circ_0002449		hsa_circ_C5orf32	C5orf32	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; RNA-seq; Microarray	hsa_circ_0002449 is down-regulated in gastric cancer and is mainly cytoplasmic. The study suggests it participates in predicted circRNA_miRNA_mRNA ceRNA networks (supported by MRE prediction and AGO2 binding-site mining) with target genes enriched in MAPK and PI3K-AKT pathways.	0.6223
34049561	Journal of translational medicine	2021	Identification of circRNA-miRNA-mRNA networks contributes to explore underlying pathogenesis and therapy strategy of gastric cancer.	hsa_circ_0003120	hsa_circ_0003012	hsa_circ_SLC41A2	SLC41A2	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; RNA-seq; Microarray	"The study reports decreased expression of this circRNA in gastric cancer and cytoplasmic enrichment, and proposes it participates in predicted circRNA_miRNA_mRNA ceRNA networks (with AGO2 binding-site evidence) linked to MAPK and PI3K-AKT pathway-enriched target genes. The paper inconsistently labels it as hsa_circ_0003120 in the text and hsa_circ_0003012 in a table/figure caption."	0.6223
34050132	Cell death discovery	2021	hsa_circ_0008234 inhibits the progression of lung adenocarcinoma by sponging miR-574-5p.	hsa_circ_0008234	circ_0008234 	hsa_circ_FOXP1	FOXP1	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0008234 is down-regulated in LUAC and acts as a tumor suppressor by inhibiting proliferation and promoting apoptosis in vitro and in xenograft models. Mechanistically, it functions as a ceRNA that sponges miR-574-5p to increase RND3 expression, and higher circ_0008234 levels are associated with better patient prognosis."	0.8426
34052838	Cell death discovery	2021	"Effect of circular RNA, mmu_circ_0000296, on neuronal apoptosis in chronic cerebral ischaemia via the miR-194-5p/Runx3/Sirt1 axis."	mmu_circ_0000296	circ_0000296 	mmu_circ_Nufip2	Nufip2	chronic cerebral ischaemia 	MONDO:0002679	cerebral infarction	down-regulated	RT-qPCR	"mmu_circ_0000296 is down-regulated in CCI models (OGD-treated HT22 cells and mouse hippocampus) and its overexpression reduces CCI-induced neuronal apoptosis. Mechanistically, it binds miR-194-5p to relieve repression of Runx3, which then enhances Sirt1 transcription to mediate an anti-apoptotic effect."	0.6678
34054343	Mediators of inflammation	2021	Involvement of circRNAs in Proinflammatory Cytokines-Mediated beta-Cell Dysfunction.		circRNAs 006029 			type 1 diabetes	MONDO:0005147	type 1 diabetes mellitus	up-regulated	RT-qPCR; Microarray	circRNA 006029 was identified as up-regulated in cytokine-treated MIN6 pancreatic beta-cells (in a type 1 diabetes-related inflammatory context) by microarray and validated by qRT-PCR. No functional knockdown or mechanistic axis was reported for this circRNA in the study.	0.1904
34054343	Mediators of inflammation	2021	Involvement of circRNAs in Proinflammatory Cytokines-Mediated beta-Cell Dysfunction.		circRNAs 013053 			type 1 diabetes	MONDO:0005147	type 1 diabetes mellitus	up-regulated	RT-qPCR; Microarray	circRNA 013053 was identified as up-regulated in cytokine-treated MIN6 pancreatic beta-cells (a type 1 diabetes-related inflammatory context) by microarray and validated by qRT-PCR. The paper did not report functional perturbation experiments or a defined regulatory axis for circRNA 013053.	0.1904
34054343	Mediators of inflammation	2021	Involvement of circRNAs in Proinflammatory Cytokines-Mediated beta-Cell Dysfunction.		circRNAs 000286 			type 1 diabetes	MONDO:0005147	type 1 diabetes mellitus	down-regulated	RT-qPCR; Microarray	"circRNA 000286 is down-regulated in cytokine-treated MIN6 beta-cells. siRNA-mediated inhibition of circRNA 000286 reduces proinsulin mRNA/insulin content and impairs glucose-stimulated insulin secretion, while increasing beta-cell apoptosis. The authors propose a predicted circRNA-miRNA-mRNA (ceRNA) network as a potential mechanism and report enrichment of TGF-beta and MAPK signaling pathways among related genes."	0.4469
34054343	Mediators of inflammation	2021	Involvement of circRNAs in Proinflammatory Cytokines-Mediated beta-Cell Dysfunction.		circRNAs 017277 			type 1 diabetes	MONDO:0005147	type 1 diabetes mellitus	down-regulated	RT-qPCR; Microarray	"circRNA 017277 is down-regulated in cytokine-treated MIN6 beta-cells. Knockdown of circRNA 017277 reduces insulin biosynthesis/content and impairs glucose-stimulated insulin secretion, while promoting beta-cell apoptosis. The study proposes a predicted circRNA-miRNA-mRNA ceRNA network (including a possible interaction with miR-34a) and reports enrichment of TGF-beta and MAPK signaling pathways among related genes."	0.4469
34054537	Frontiers in pharmacology	2021	CircRNA circ_0006677 Inhibits the Progression and Glycolysis in Non-Small-Cell Lung Cancer by Sponging miR-578 and Regulating SOCS2 Expression.	hsa_circ_0006677	circ_0006677 			non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"circ_0006677 is down-regulated in NSCLC and its low expression is associated with worse overall survival. Functionally, circ_0006677 suppresses NSCLC cell proliferation, migration, invasion, and glycolysis and inhibits xenograft tumor growth. Mechanistically, it acts as a miR-578 sponge to upregulate SOCS2 (circ_0006677/miR-578/SOCS2 axis)."	0.8423
34055022	Evidence-based complementary and alternative medicine : eCAM	2021	Effects of Berberine on Circular RNA Expression Profiles in Human Gastric Cancer Cells.		circRNA2499			gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"circRNA2499 was identified as a berberine-responsive circRNA that is up-regulated in AGS and HGC27 gastric cancer cells after berberine treatment. The study predicts that it may function as a miRNA sponge within a circRNA-miRNA-mRNA network, with target-gene enrichment suggesting involvement in cell-cycle-related processes (e.g., mitotic prometaphase)."	0.2465
34055022	Evidence-based complementary and alternative medicine : eCAM	2021	Effects of Berberine on Circular RNA Expression Profiles in Human Gastric Cancer Cells.	hsa_circ_0003423				gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0003423 is up-regulated by berberine treatment in gastric cancer cell lines. The study predicts a ceRNA role for hsa_circ_0003423 as a miRNA sponge, with enrichment of its putative target genes pointing to MAPK-family signaling cascades and ER-stress-related responses."	0.2465
34055022	Evidence-based complementary and alternative medicine : eCAM	2021	Effects of Berberine on Circular RNA Expression Profiles in Human Gastric Cancer Cells.	hsa_circ_0006702				gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0006702 is significantly up-regulated in berberine-treated gastric cancer cells. It is modeled as a miRNA sponge in a predicted circRNA-miRNA-mRNA network, and enrichment of predicted targets suggests links to NF-kappaB-related signaling and cell-cycle regulation (including G2/M transition)."	0.2465
34055022	Evidence-based complementary and alternative medicine : eCAM	2021	Effects of Berberine on Circular RNA Expression Profiles in Human Gastric Cancer Cells.	hsa_circ_0070562				gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	hsa_circ_0070562 was among the differentially expressed circRNAs selected for RT-qPCR validation and was significantly up-regulated in berberine-treated AGS and HGC27 gastric cancer cells. The paper does not further analyze its downstream mechanism or functional pathways.	0.1155
34055636	Frontiers in oncology	2021	A Comprehensive RNA Study to Identify circRNA and miRNA Biomarkers for Docetaxel Resistance in Breast Cancer.		circABCB1 	hsa_circ_ABCB1	ABCB1	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	"circABCB1 is strongly up-regulated in docetaxel-resistant breast cancer cell lines. It is proposed to act as a ceRNA/miRNA sponge (e.g., miR-877-3p) and thereby promote ABCB1 expression, contributing to docetaxel resistance, with pathway associations inferred from enrichment (PI3K-Akt and AGE-RAGE)."	0.4761
34055636	Frontiers in oncology	2021	A Comprehensive RNA Study to Identify circRNA and miRNA Biomarkers for Docetaxel Resistance in Breast Cancer.		circEPHA3.1 	hsa_circ_EPHA3	EPHA3	breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; RNA-seq	"circEPHA3.1 is strongly down-regulated in docetaxel-resistant breast cancer cell lines. It is proposed to modulate docetaxel response by sponging miR-346; loss of circEPHA3.1 may relieve miR-346 inhibition and contribute to resistance, with pathway associations inferred from enrichment analyses."	0.4761
34055636	Frontiers in oncology	2021	A Comprehensive RNA Study to Identify circRNA and miRNA Biomarkers for Docetaxel Resistance in Breast Cancer.		circEPHA3.2 	hsa_circ_EPHA3	EPHA3	breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; RNA-seq	"circEPHA3.2 is strongly down-regulated in docetaxel-resistant breast cancer cell lines. It is predicted to interact with chemotherapy-associated miRNAs (including miR-1248, miR-204-5p/3p, and miR-124-3p) and may help maintain docetaxel sensitivity, with broader pathway associations inferred from miRNA target enrichment (PI3K-Akt and AGE-RAGE)."	0.4761
34055775	Frontiers in cell and developmental biology	2021	Mechanism of circADD2 as ceRNA in Childhood Acute Lymphoblastic Leukemia.	hsa_circ_0120872	circADD2	hsa_circ_ADD2	ADD2	childhood acute lymphoblastic leukemia 	MONDO:0000870	childhood acute lymphoblastic leukemia	down-regulated	RT-qPCR; Microarray	"circADD2 (hsa_circ_0120872), derived from the ADD2 gene, is down-regulated in childhood ALL bone marrow and ALL cell lines. Its overexpression suppresses leukemia cell proliferation and tumor growth and promotes apoptosis, mainly by sponging miR-149-5p and reducing AKT2 expression."	0.7845
34055896	Frontiers in molecular biosciences	2021	Silencing of circRNA circ_0001666 Represses EMT in Pancreatic Cancer Through Upregulating miR-1251 and Downregulating SOX4.	hsa_circ_0001666	circ_0001666	hsa_circ_FAM120B	FAM120B	Pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"circ_0001666 is up-regulated in pancreatic cancer and promotes proliferation, EMT and invasion. Mechanistically, it functions as a miR-1251 sponge to de-repress SOX4 (and increase EZH2), and high circ_0001666 expression is associated with poorer overall survival."	0.8219
34056113	Open life sciences	2021	Mechanisms of circular RNA circ_0066147 on pancreatic cancer progression.	hsa_circ_0066147	circ_0066147 	hsa_circ_SFMBT1	SFMBT1	pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; Microarray	"circ_0066147 (circSFMBT1; hsa_circ_103390) is up-regulated in pancreatic cancer and promotes malignant behaviors (proliferation, migration, invasion) while inhibiting apoptosis, and it supports xenograft tumor growth. It functions mainly via a ceRNA mechanism, sponging miR-326 to increase E2F2 expression (circ_0066147/miR-326/E2F2 axis), and its high expression is associated with poorer patient survival."	0.8595
34057019	Bioengineered	2021	Circular RNA circ_0001162 promotes cell proliferation and invasion of glioma via the miR-936/ERBB4 axis.	hsa_circ_0001162	circ_0001162	hsa_circ_MMP9	MMP9	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ_0001162 is up-regulated in glioma tissues and cell lines and predominantly localizes to the cytoplasm. It promotes glioma proliferation, colony formation, migration, invasion, and xenograft tumor growth by sponging miR-936 and thereby increasing ERBB4 expression (circ_0001162/miR-936/ERBB4 axis)."	0.8119
34058990	"Molecular medicine (Cambridge, Mass.)"	2021	CircHYBID regulates hyaluronan metabolism in chondrocytes via hsa-miR-29b-3p/TGF-beta1 axis.	hsa_circ_0003893	circHYBID 	hsa_circ_KIAA1199	KIAA1199	osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR; RNA-seq	"In osteoarthritis cartilage and IL-1beta-stimulated human chondrocytes, circHYBID is down-regulated. circHYBID overexpression increases HA accumulation and modulates HA-metabolism enzymes (decreases HYBID and restores HAS2). Mechanistically, it sponges hsa-miR-29b-3p to upregulate TGF-beta1, forming a circHYBID/miR-29b-3p/TGF-beta1 axis that regulates HA metabolism and may be therapeutically relevant in OA."	0.8082
34060415	Bioengineered	2021	Circular RNA 0102049 suppresses the progression of osteosarcoma through modulating miR-520g-3p/PLK2 axis.	hsa_circ_0102049	circ_0102049			osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"This study shows circ_0102049 acts as a tumor suppressor in osteosarcoma models. Silencing circ_0102049 promotes tumor growth and enhances MG63 cell proliferation, migration and invasion while reducing apoptosis, mainly through a ceRNA mechanism involving miR-520g-3p and downstream PLK2 (and TAp73)."	0.6276
34074294	Molecular cancer	2021	The circular RNA circSPARC enhances the migration and proliferation of colorectal cancer by regulating the JAK/STAT pathway.	hsa_circ_0004104	circSPARC	hsa_circ_SPARC	SPARC	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"circSPARC (hsa_circ_0004104), derived from SPARC, is upregulated in CRC tissues and plasma and promotes CRC proliferation, migration, invasion, tumor growth and metastasis. It acts as a cytoplasmic ceRNA sponging miR-485-3p to increase JAK2 expression and enhance JAK2/STAT3 signaling (increased p-STAT3), and also recruits the RBP FUS to facilitate nuclear translocation of p-STAT3. High circSPARC is associated with advanced clinicopathologic features and poorer overall survival, with potential diagnostic/prognostic value."	0.9033
34077306	Bioengineered	2021	Circular RNA circ_0003028 contributes to tumorigenesis by regulating GOT2 via miR-1298-5p in non-small cell lung cancer.	hsa_circ_0003028	circ_0003028	hsa_circ_FUT8	FUT8	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0003028 is up-regulated in NSCLC tissues and cell lines and mainly localizes to the cytoplasm. It promotes malignant phenotypes (proliferation, migration/invasion, angiogenesis) and tumor growth by sponging miR-1298-5p to increase GOT2 expression, while its knockdown increases apoptosis and autophagy."	0.8201
34078991	Scientific reports	2021	Reconstruction of circRNA-miRNA-mRNA associated ceRNA networks reveal functional circRNAs in intracerebral hemorrhage.		novel_circ_0004272			intracerebral hemorrhage 	MONDO:0013792	intracerebral hemorrhage	unknown	RNA-seq	"In ICH rat brain (day 7), novel_circ_0004272 is identified as a hub circRNA in a ceRNA network, predicted to sponge rno-miR-134-3p and thereby associate with Grk3 regulation. This hub module is implicated in early-stage ICH-related processes and pathways including chemokine signaling and Hedgehog-related annotations via the target gene Grk3."	0.1768
34078991	Scientific reports	2021	Reconstruction of circRNA-miRNA-mRNA associated ceRNA networks reveal functional circRNAs in intracerebral hemorrhage.		novel_circ_0020253			intracerebral hemorrhage 	MONDO:0013792	intracerebral hemorrhage	unknown	RNA-seq	"In ICH rat brain (day 28), novel_circ_0020253 is highlighted as a hub circRNA within a ceRNA module predicted to sponge rno-miR-1224 and associate with Vegfa. This module is linked to VEGF-related vascular repair/angiogenesis programs in chronic-stage ICH via the Vegfa target."	0.1768
34079579	Frontiers in genetics	2021	Construction of a circRNA-miRNA-mRNA Regulatory Network Reveals Potential Mechanism and Treatment Options for Osteosarcoma.	hsa_circ_0000253		hsa_circ_BLNK	BLNK	osteosarcoma	MONDO:0009807	osteosarcoma	up-regulated	Microarray	"This study identified hsa_circ_0000253 as an up-regulated circRNA in osteosarcoma based on circRNA microarray data, suggesting a potential tumor-promoting role, but without experimental validation or a specific mechanistic axis."	0.1768
34079579	Frontiers in genetics	2021	Construction of a circRNA-miRNA-mRNA Regulatory Network Reveals Potential Mechanism and Treatment Options for Osteosarcoma.	hsa_circ_0010220		hsa_circ_ARHGEF10L	ARHGEF10L	osteosarcoma	MONDO:0009807	osteosarcoma	up-regulated	Microarray	"This study identified hsa_circ_0010220 as up-regulated in osteosarcoma tissues by circRNA microarray and placed it in a predicted circRNA-miRNA-mRNA subnetwork with hsa-miR-940/hsa-miR-223 and STC2/RASGRP2, consistent with a putative ceRNA role, but without experimental validation."	0.1768
34079579	Frontiers in genetics	2021	Construction of a circRNA-miRNA-mRNA Regulatory Network Reveals Potential Mechanism and Treatment Options for Osteosarcoma.	hsa_circ_0020378		hsa_circ_DOCK1	DOCK1	osteosarcoma	MONDO:0009807	osteosarcoma	up-regulated	Microarray	"This study identified hsa_circ_0020378 as up-regulated in osteosarcoma tissues by circRNA microarray and included it in a predicted subnetwork with hsa-miR-940/hsa-miR-223 and STC2/RASGRP2, suggesting a potential ceRNA role without experimental validation."	0.1768
34079579	Frontiers in genetics	2021	Construction of a circRNA-miRNA-mRNA Regulatory Network Reveals Potential Mechanism and Treatment Options for Osteosarcoma.	hsa_circ_0049271		hsa_circ_KEAP1	KEAP1	osteosarcoma	MONDO:0009807	osteosarcoma	down-regulated	Microarray	"This study found hsa_circ_0049271 to be down-regulated in osteosarcoma tissues in a circRNA microarray dataset, suggesting a potential tumor-inhibitory role, without mechanistic or experimental validation."	0.1768
34079579	Frontiers in genetics	2021	Construction of a circRNA-miRNA-mRNA Regulatory Network Reveals Potential Mechanism and Treatment Options for Osteosarcoma.	hsa_circ_0000006		hsa_circ_SLC35E2B	SLC35E2B	osteosarcoma	MONDO:0009807	osteosarcoma	down-regulated	Microarray	"This study identified hsa_circ_0000006 as down-regulated in osteosarcoma tissues by circRNA microarray and placed it into a predicted circRNA-miRNA-mRNA subnetwork involving hsa-miR-940/hsa-miR-223 and STC2/RASGRP2, suggesting a putative ceRNA relationship without experimental validation."	0.1768
34079579	Frontiers in genetics	2021	Construction of a circRNA-miRNA-mRNA Regulatory Network Reveals Potential Mechanism and Treatment Options for Osteosarcoma.	hsa_circ_0078767		hsa_circ_FAM120B	FAM120B	osteosarcoma	MONDO:0009807	osteosarcoma	down-regulated	Microarray	"This study identified hsa_circ_0078767 as down-regulated in osteosarcoma tissues by circRNA microarray and included it in a predicted subnetwork with hsa-miR-940/hsa-miR-223 and STC2/RASGRP2, implying a possible ceRNA relationship without experimental validation."	0.1768
34079579	Frontiers in genetics	2021	Construction of a circRNA-miRNA-mRNA Regulatory Network Reveals Potential Mechanism and Treatment Options for Osteosarcoma.	hsa_circ_0046264		hsa_circ_P4HB	P4HB	osteosarcoma	MONDO:0009807	osteosarcoma	down-regulated	Microarray	"This study identified hsa_circ_0046264 as down-regulated in osteosarcoma tissues and placed it into a predicted circRNA-miRNA-mRNA subnetwork involving hsa-miR-940/hsa-miR-223 and STC2/RASGRP2, suggesting a potential ceRNA role without experimental validation."	0.1768
34079579	Frontiers in genetics	2021	Construction of a circRNA-miRNA-mRNA Regulatory Network Reveals Potential Mechanism and Treatment Options for Osteosarcoma.	hsa_circ_0094088		hsa_circ_SFMBT2	SFMBT2	osteosarcoma	MONDO:0009807	osteosarcoma	down-regulated	Microarray	"This study identified hsa_circ_0094088 as down-regulated in osteosarcoma tissues by circRNA microarray and included it in a predicted subnetwork with hsa-miR-940/hsa-miR-223 and STC2/RASGRP2, suggesting a possible ceRNA relationship without experimental validation."	0.1768
34079579	Frontiers in genetics	2021	Construction of a circRNA-miRNA-mRNA Regulatory Network Reveals Potential Mechanism and Treatment Options for Osteosarcoma.	hsa_circ_0096041		hsa_circ_FADS2	FADS2	osteosarcoma	MONDO:0009807	osteosarcoma	down-regulated	Microarray	"This study identified hsa_circ_0096041 as down-regulated in osteosarcoma tissues in a circRNA microarray dataset, suggesting a potential tumor-inhibitory role, without mechanistic or experimental validation."	0.1768
34079759	Frontiers in oncology	2021	CircHECTD1 Regulates Cell Proliferation and Migration by the miR-320-5p/SLC2A1 Axis in Glioblastoma Multiform.		circHECTD1	hsa_circ_HECTD1	HECTD1	Glioblastoma multiform 	MONDO:0018177	glioblastoma	unknown	RT-qPCR	"circHECTD1 promotes glioblastoma multiform cell proliferation and migration and enhances tumor growth in xenografts. It functions as a ceRNA that sponges miR-320-5p, thereby increasing SLC2A1 expression."	0.8143
34080649	Molecular medicine reports	2021	circSAMD4A participates in the apoptosis and autophagy of dopaminergic neurons via the miR_29c_3p_mediated AMPK/mTOR pathway in Parkinson's disease.	hsa_circ_0004846	circSAMD4A 	hsa_circ_SAMD4A	SAMD4A	Parkinson's disease 	MONDO:0005180	Parkinson disease	up-regulated	RT-qPCR	"circSAMD4A is upregulated in PD models and promotes dopaminergic neuron apoptosis and autophagy. Mechanistically, circSAMD4A directly targets and negatively regulates miR-29c-3p, thereby modulating the AMPK/mTOR signaling cascade; circSAMD4A knockdown is protective and this protection is reversed by a miR-29c-3p inhibitor."	0.5607
34080658	Oncology reports	2021	circNSUN2 promotes the malignant biological behavior of colorectal cancer cells via the miR_181a_5p/ROCK2 axis.		circNSUN2 	hsa_circ_NSUN2	"NOP2/Sun domain family, member 2"	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circNSUN2 is up-regulated in colorectal cancer tissues and cell lines and promotes malignant phenotypes (proliferation and migration) while inhibiting apoptosis. Mechanistically, it sponges miR-181a-5p to increase ROCK2 expression, driving CRC progression and tumor growth in vivo."	0.6542
34082777	World journal of surgical oncology	2021	Hsa_circ_0001982 promotes the progression of breast cancer through miR-1287-5p/MUC19 axis under hypoxia.	hsa_circ_0001982	circ_0001982	hsa_circ_RNF111	RNF111	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"In breast cancer, circ_0001982 is up-regulated (including under hypoxia) and mainly localized in the cytoplasm. It promotes glycolysis and malignant behaviors (viability/proliferation, migration, invasion) by acting as a ceRNA sponge for miR-1287-5p, thereby increasing MUC19 expression, and its knockdown suppresses xenograft tumor growth."	0.7283
34082824	Arthritis research & therapy	2021	Exosomal circ-BRWD1 contributes to osteoarthritis development through the modulation of miR-1277/TRAF6 axis.	hsa_circ_0116061	circ-BRWD1 	hsa_circ_BRWD1	BRWD1	osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circ-BRWD1 is upregulated in osteoarthritis cartilage and IL-1beta-stimulated chondrocytes and is enriched in the cytoplasm. It is transmitted via exosomes and aggravates IL-1beta-induced chondrocyte injury by sponging miR-1277 to increase TRAF6, thereby promoting apoptosis, inflammation and ECM degradation while reducing cell viability/proliferation."	0.7631
34090465	Molecular cancer	2021	CHEK1 and circCHEK1_246aa evoke chromosomal instability and induce bone lesion formation in multiple myeloma.		circCHEK1_246aa 	hsa_circ_CHEK1	CHEK1	multiple myeloma 	MONDO:0009693	plasma cell myeloma	unknown	RT-qPCR	"circCHEK1_246aa (from CHEK1) is a protein-coding circRNA translated into a 246-aa CHEK1 isoform. Its expression/overexpression promotes chromosomal instability and enhances osteoclast differentiation, contributing to myeloma aggressiveness and bone lesion formation, and it can interact with CEP170."	0.7505
34093041	Cancer management and research	2021	"circRNA-TBC1D4, circRNA-NAALAD2 and circRNA-TGFBR3: Selected Key circRNAs in Neuroblastoma and Their Associations with Clinical Features."		circRNA-TBC1D4 	hsa_circ_TBC1D4	TBC1D4	neuroblastoma 	MONDO:0005072	neuroblastoma	down-regulated	RT-qPCR; RNA-seq	"circRNA-TBC1D4 is significantly down-regulated in neuroblastoma tissues versus adjacent adrenal medulla and is predicted to sponge miR-21. Functionally, circRNA-TBC1D4 overexpression in SH-SY5Y cells reduces migration, and its low expression correlates with clinical features such as MYCN status and LDH."	0.725
34093041	Cancer management and research	2021	"circRNA-TBC1D4, circRNA-NAALAD2 and circRNA-TGFBR3: Selected Key circRNAs in Neuroblastoma and Their Associations with Clinical Features."		circRNA-NAALAD2	hsa_circ_NAALAD2	NAALAD2	neuroblastoma 	MONDO:0005072	neuroblastoma	down-regulated	RT-qPCR; RNA-seq	circRNA-NAALAD2 is significantly down-regulated in neuroblastoma tissues and is predicted to bind (sponge) miR-21. Its reduced expression correlates with LDH and may indicate an unfavorable neuroblastoma type.	0.585
34093041	Cancer management and research	2021	"circRNA-TBC1D4, circRNA-NAALAD2 and circRNA-TGFBR3: Selected Key circRNAs in Neuroblastoma and Their Associations with Clinical Features."		circRNA-TGFBR3	hsa_circ_TGFBR3	TGFBR3	neuroblastoma 	MONDO:0005072	neuroblastoma	down-regulated	RT-qPCR; RNA-seq	circRNA-TGFBR3 is significantly down-regulated in neuroblastoma tissues and is predicted to bind (sponge) miR-21. Its downregulation correlates with histology category and may indicate an unfavorable neuroblastoma type.	0.585
34093124	Frontiers in molecular neuroscience	2021	CircRNA-ceRNA Network Revealing the Potential Regulatory Roles of CircRNA in Alzheimer's Disease Involved the cGMP-PKG Signal Pathway.		novel_circ_0003012	mmu_circ_Adcy6	Adcy6	Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR; RNA-seq	novel_circ_0003012 is up-regulated in APP/PS1 mouse hippocampus and is proposed to act as a ceRNA for mmu-miR-298-3p to regulate Smoc2. This axis may influence AD pathophysiology by affecting the cGMP-PKG signaling pathway (including reduced PKG).	0.5079
34093124	Frontiers in molecular neuroscience	2021	CircRNA-ceRNA Network Revealing the Potential Regulatory Roles of CircRNA in Alzheimer's Disease Involved the cGMP-PKG Signal Pathway.	mmu_circ_0000672		mmu_circ_Pi4ka	Pi4ka	Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR; RNA-seq	mmu_circ_0000672 is up-regulated in APP/PS1 mouse hippocampus and is implicated in an AD-related ceRNA network. It may sponge mmu-miR-351-5p to affect the target gene Cst7.	0.4375
34093163	Frontiers in aging neuroscience	2021	Circular RNA circDUS2 Is a Potential Biomarker for Intracranial Aneurysm.	hsa_circ_0039908	circDUS2 	hsa_circ_DUS2	DUS2	intracranial aneurysm 	MONDO:0005291	brain aneurysm	up-regulated	RT-qPCR; Microarray	circDUS2 (hsa_circRNA_101833; hsa_circ_0039908) is up-regulated in intracranial aneurysm tissues versus superficial temporal arteries and is proposed as a potential molecular marker. Bioinformatics analyses suggest it may act via miRNA-related regulation linked to SMAD binding and involvement of TGF-beta and MAPK signaling in IA formation; it localizes mainly to the cytoplasm in HBVSMCs.	0.4297
34093664	Frontiers in genetics	2021	"Circ-MFN2 Positively Regulates the Proliferation, Metastasis, and Radioresistance of Colorectal Cancer by Regulating the miR-574-3p/IGF1R Signaling Axis."	hsa_circ_0009910	hsa_circRNA_100053 	hsa_circ_MFN2	MFN2	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ-MFN2 is up-regulated in colorectal cancer tissues and cell lines and is associated with more advanced disease and worse overall survival. Functionally, circ-MFN2 promotes proliferation, migration/invasion (metastatic potential), and radioresistance by sponging miR-574-3p to increase IGF1R expression (circ-MFN2/miR-574-3p/IGF1R axis)."	0.7657
34093821	Journal of Cancer	2021	circ0101675 promotes malignant process via sponging miR-1278 and upregulating WNT3A/5A in non-small cell lung cancer.	hsa_circ_0101675	circ0101675	hsa_circ_NPAS3	NPAS3	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circ0101675 is up-regulated in NSCLC tissues and cell lines and promotes malignant phenotypes (proliferation, migration, metastasis). Mechanistically, it acts as a ceRNA to sponge miR-1278, leading to increased WNT3A and WNT5A expression, supporting NSCLC progression."	0.8442
34093832	Journal of Cancer	2021	Overexpressed circRANBP17 acts as an oncogene to facilitate nasopharyngeal carcinoma via the miR-635/RUNX2 axis.	hsa_circ_0001554	circRANBP17	hsa_circ_RANBP17	RANBP17	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001554 (circRANBP17), derived from RANBP17, is up-regulated in nasopharyngeal carcinoma tissues and cell lines. It promotes NPC cell proliferation and invasion and enhances tumor growth by sponging miR-635 to increase RUNX2 expression (circRANBP17/miR-635/RUNX2 ceRNA axis)."	0.8382
34093839	Journal of Cancer	2021	Identification of PGC-related ncRNAs and their relationship with the clinicopathological features of Gastric Cancer.	hsa_circ_0001483				gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"hsa_circ_0001483 is down-regulated in gastric cancer tissue and binds hsa-let-7c. It is part of a proposed PGC-related ceRNA axis (hsa_circ_0001483_hsa-let-7c_PGC) that may contribute to PGC down-regulation, and its expression is associated with inflammatory cell infiltration and lymphatic metastasis."	0.4685
34093839	Journal of Cancer	2021	Identification of PGC-related ncRNAs and their relationship with the clinicopathological features of Gastric Cancer.	hsa_circ_0001324				gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"hsa_circ_0001324 is down-regulated in gastric cancer tissue and binds hsa-let-7c. It is part of a proposed PGC-related ceRNA axis (hsa_circ_0001324_hsa-let-7c_PGC) that may contribute to PGC down-regulation, and its expression is associated with patient age."	0.4685
34094907	Frontiers in oncology	2021	Multiple Omics Integration Reveals Key Circular RNAs in Hepatocellular Carcinoma.	hsa_circ_0141900		hsa_circ_RAB1A	RAB1A	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RNA-seq	"hsa_circ_0141900 is down-regulated in HCC and shows a strong negative correlation with its host gene RAB1A, suggesting a potential isoform-switch relationship. Its correlated gene signature is enriched for mTOR-related signaling, linking this circRNA to PI3K/AKT/mTOR pathway dysregulation in HCC."	0.1768
34094907	Frontiers in oncology	2021	Multiple Omics Integration Reveals Key Circular RNAs in Hepatocellular Carcinoma.	hsa_circ_0002130				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0002130 is a downregulated ceRNA-network circRNA in HCC and, when overexpressed in HCC cell lines, suppresses cell proliferation while increasing GOT2 RNA and protein expression. The study proposes that hsa_circ_0002130 may act as a miRNA sponge to upregulate GOT2 and affect gluconeogenesis-related programs."	0.4852
34094907	Frontiers in oncology	2021	Multiple Omics Integration Reveals Key Circular RNAs in Hepatocellular Carcinoma.	hsa_circ_0008774				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RNA-seq	"hsa_circ_0008774 is a downregulated circRNA in an HCC ceRNA network and is computationally linked to AR as a target gene. The study suggests it may act upstream of AR signaling and relate to HNF3A-pathway-associated gene programs, but lacks experimental validation for this circRNA."	0.1768
34095115	Frontiers in cell and developmental biology	2021	Diagnostic Biomarker Hsa_circ_0126218 and Functioning Prediction in Peripheral Blood Monocular Cells of Female Patients With Major Depressive Disorder.	hsa_circ_0126218		hsa_circ_ZNF141	ZNF141	major depressive disorder 	MONDO:0002009	major depressive disorder	up-regulated	RT-qPCR; RNA-seq	"In female MDD PBMCs, hsa_circ_0126218 is up-regulated and shows diagnostic potential (AUC ~0.80). The study predicts a ceRNA mechanism by constructing a circRNA_miRNA_mRNA network and identifying downstream hub genes (e.g., PIK3CA, PTEN, MAPK1), with enrichment in pathways including Wnt and MAPK, but these mechanistic predictions were not experimentally validated."	0.5047
34095115	Frontiers in cell and developmental biology	2021	Diagnostic Biomarker Hsa_circ_0126218 and Functioning Prediction in Peripheral Blood Monocular Cells of Female Patients With Major Depressive Disorder.	hsa_circ_0006862		hsa_circ_DTL	DTL	major depressive disorder 	MONDO:0002009	major depressive disorder	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0006862 is up-regulated in PBMCs of female MDD patients in the preliminary RT-qPCR validation cohort and shows moderate diagnostic performance by ROC analysis (AUC 0.726). No downstream miRNA/mRNA mechanism for hsa_circ_0006862 is reported in this study.	0.4679
34096174	Thoracic cancer	2021	Circular RNA circLDB2 functions as a competing endogenous RNA to suppress development and promote cisplatin sensitivity in non-squamous non-small cell lung cancer.	hsa_circ_0069244	circLDB2 	hsa_circ_LDB2	LDB2	non-squamous non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"circLDB2 is down-regulated in non-squamous NSCLC and functions as a cytoplasmic ceRNA that sponges miR-346 to increase LIMCH1 expression, thereby inhibiting malignant phenotypes and improving cisplatin sensitivity (with increased p53/PUMA)."	0.8546
34096776	Molecular and cellular biology	2021	Circular RNA hsa_circ_0032463 Acts as the Tumor Promoter in Osteosarcoma by Regulating the MicroRNA 498/LEF1 Axis.	hsa_circ_0032463	circ_0032463	hsa_circ_SIPA1L1	SIPA1L1	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"In osteosarcoma, circ_0032463 (hsa_circ_0032463) is upregulated and mainly localized in the cytoplasm. It promotes proliferation and migration and inhibits apoptosis by sponging miR-498 to enhance LEF1 expression, forming a circ_0032463/miR-498/LEF1 regulatory axis."	0.8058
34098829	Bioengineered	2021	The functions of fluoxetine and identification of fluoxetine-mediated circular RNAs and messenger RNAs in cerebral ischemic stroke.		circMap2k1 	rno_circ_Map2k1	Map2k1	cerebral ischemic stroke 	MONDO:0005264	transient ischemic attack	up-regulated	RT-qPCR; RNA-seq	circMap2k1 is up-regulated in the rat MCAO ischemic stroke model and is suppressed after fluoxetine treatment. It directly binds rno-miR-135b-5p and is proposed to affect Pidd1 via a circMap2k1/miR-135b-5p/Pidd1 regulatory axis that may contribute to fluoxetine-mediated protection in ischemic stroke.	0.7605
34098865	Cellular & molecular biology letters	2021	Circular RNA expression profile in transgenic diabetic mouse kidneys.		circR_1084	mmu_circ_Aak1	Aak1	diabetic nephropathy	MONDO:0005016	diabetic kidney disease	down-regulated	RT-qPCR; RNA-seq	"circR_1084 is down-regulated in renal tissues of diabetic nephropathy model BKS-DB/Nju mice (8 and 16 weeks) versus WT, identified by RNA-seq and verified by RT-qPCR."	0.5541
34098865	Cellular & molecular biology letters	2021	Circular RNA expression profile in transgenic diabetic mouse kidneys.	mmu_circ_0000242	circR_182	mmu_circ_Aftph	Aftph	diabetic nephropathy	MONDO:0005016	diabetic kidney disease	down-regulated	RT-qPCR; RNA-seq	"circR_182 (mmu_circ_0000242) is down-regulated in renal tissues of diabetic nephropathy model BKS-DB/Nju mice (8 and 16 weeks) versus WT, discovered by RNA-seq and confirmed by RT-qPCR."	0.5541
34098865	Cellular & molecular biology letters	2021	Circular RNA expression profile in transgenic diabetic mouse kidneys.		circR_4	mmu_circ_Epb41l5	Epb41l5	diabetic nephropathy	MONDO:0005016	diabetic kidney disease	down-regulated	RT-qPCR; RNA-seq	"circR_4 is down-regulated in renal tissues of diabetic nephropathy model BKS-DB/Nju mice (8 and 16 weeks) versus WT, supported by RNA-seq and validated by RT-qPCR."	0.5541
34098865	Cellular & molecular biology letters	2021	Circular RNA expression profile in transgenic diabetic mouse kidneys.	mmu_circ_0000130	circR_50	mmu_circ_Ptpn14	Ptpn14	diabetic nephropathy	MONDO:0005016	diabetic kidney disease	down-regulated	RT-qPCR; RNA-seq	"circR_50 (mmu_circ_0000130) is down-regulated in renal tissues of BKS-DB/Nju diabetic nephropathy mice at 8 and 16 weeks, relative to WT, with RNA-seq discovery and RT-qPCR validation."	0.5541
34098865	Cellular & molecular biology letters	2021	Circular RNA expression profile in transgenic diabetic mouse kidneys.		circR_596	mmu_circ_Myo5b	Myo5b	diabetic nephropathy	MONDO:0005016	diabetic kidney disease	down-regulated	RT-qPCR; RNA-seq	"circR_596 is down-regulated in renal tissues of the BKS-DB/Nju diabetic nephropathy mouse model at 8 and 16 weeks versus WT, supported by RNA-seq and validated by RT-qPCR."	0.5541
34098865	Cellular & molecular biology letters	2021	Circular RNA expression profile in transgenic diabetic mouse kidneys.		circR_897	mmu_circ_Rnf38	Rnf38	diabetic nephropathy	MONDO:0005016	diabetic kidney disease	down-regulated	RT-qPCR; RNA-seq	"circR_897 is down-regulated in renal tissues of BKS-DB/Nju diabetic nephropathy mice (8 and 16 weeks) compared with WT, identified by RNA-seq and validated by RT-qPCR."	0.5541
34098865	Cellular & molecular biology letters	2021	Circular RNA expression profile in transgenic diabetic mouse kidneys.		circR_203	mmu_circ_Gpx3	Gpx3	diabetic nephropathy	MONDO:0005016	diabetic kidney disease	down-regulated	RT-qPCR; RNA-seq	"circR_203 is down-regulated in renal tissues of BKS-DB/Nju diabetic nephropathy mice (8 and 16 weeks) versus WT, discovered by RNA-seq and validated by RT-qPCR."	0.5541
34098865	Cellular & molecular biology letters	2021	Circular RNA expression profile in transgenic diabetic mouse kidneys.	mmu_circ_0000943	circR_627	mmu_circ_Glis3	Glis3	diabetic nephropathy	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR; RNA-seq	circR_627 (mmu_circ_0000943; host gene Glis3) is up-regulated in renal tissues of BKS-DB/Nju diabetic nephropathy mice at 8 and 16 weeks versus WT; ceRNA-related interactions were only computationally predicted.	0.585
34098865	Cellular & molecular biology letters	2021	Circular RNA expression profile in transgenic diabetic mouse kidneys.		circR_628	mmu_circ_Glis3	Glis3	diabetic nephropathy	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR; RNA-seq	circR_628 (host gene Glis3) is up-regulated in renal tissues from BKS-DB/Nju diabetic nephropathy mice at 8 and 16 weeks versus WT; its ceRNA-related interactions were only predicted computationally.	0.585
34098865	Cellular & molecular biology letters	2021	Circular RNA expression profile in transgenic diabetic mouse kidneys.		circR_735	mmu_circ_Camsap1	Camsap1	diabetic nephropathy	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR; RNA-seq	circR_735 is up-regulated in renal tissues of BKS-DB/Nju diabetic nephropathy mice (8 and 16 weeks) versus WT; ceRNA-related roles were suggested only by computational MRE/target prediction.	0.585
34098865	Cellular & molecular biology letters	2021	Circular RNA expression profile in transgenic diabetic mouse kidneys.		circR_801	mmu_circ_Spata1	Spata1	diabetic nephropathy	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR; RNA-seq	circR_801 is up-regulated in renal tissues of BKS-DB/Nju diabetic nephropathy mice (8 and 16 weeks) compared with WT; ceRNA-related functions were only suggested by bioinformatic MRE/target prediction.	0.585
34100450	Neural regeneration research	2022	Down-regulating Circular RNA Prkcsh suppresses the inflammatory response after spinal cord injury.		circPrkcsh	mmu_circ_Prkcsh	Prkcsh	spinal cord injury 	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR; RNA-seq	"circPrkcsh is up-regulated after spinal cord injury and promotes an inflammatory phenotype. It functions mainly in the cytoplasm as a miR-488 sponge, relieving miR-488 repression of Ccl2/CCL2, thereby increasing inflammatory cytokine expression/secretion; circPrkcsh knockdown attenuates inflammation in TNF-alpha-treated astrocytes."	0.8036
34102907	The Journal of international medical research	2021	"circVAPA promotes the proliferation, migration and invasion of oral cancer cells through the miR-132/HOXA7 axis."		circVAPA	hsa_circ_VAPA		oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circVAPA is up-regulated in OSCC tissues/cell lines and functions as an oncogenic circRNA. It promotes oral cancer cell proliferation, migration, and invasion by sponging miR-132 and relieving miR-132-mediated repression of HOXA7, and its high expression correlates with worse OS/PFS."	0.7537
34103911	International journal of chronic obstructive pulmonary disease	2021	Circ-HACE1 Aggravates Cigarette Smoke Extract-Induced Injury in Human Bronchial Epithelial Cells via Regulating Toll-Like Receptor 4 by Sponging miR-485-3p.	hsa_circ_0077520	circ-HACE1	hsa_circ_HACE1	HACE1	chronic obstructive pulmonary disease 	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR	"Circ-HACE1 is up-regulated in serum from smokers/smokers with COPD and in CSE-treated 16HBE cells. Functionally, it aggravates CSE-induced bronchial epithelial injury by sponging miR-485-3p to increase TLR4, promoting apoptosis, inflammation, and oxidative stress; circ-HACE1 knockdown is protective and is proposed as a diagnostic biomarker/therapeutic target for COPD."	0.7416
34103991	Cancer management and research	2021	Grape Seed Proanthocyanidins (GSPs) Inhibit the Development of Cutaneous Squamous Cell Carcinoma by Regulating the hsa_circ_0070934/miR-136-5p/PRAF2 Axis.	hsa_circ_0070934				cutaneous squamous cell carcinoma 	MONDO:0002529	skin squamous cell carcinoma	up-regulated	RT-qPCR	"In CSCC, hsa_circ_0070934 functions as an oncogenic circRNA. It sponges miR-136-5p to upregulate PRAF2, promoting proliferation, cell-cycle progression, migration/invasion and reducing apoptosis; GSPs suppress CSCC by decreasing hsa_circ_0070934 and inhibiting this axis in vitro and in xenograft tumors."	0.7797
34103997	Cancer management and research	2021	CircPRDM2 Contributes to Doxorubicin Resistance of Osteosarcoma by Elevating EZH2 via Sponging miR-760.	hsa_circ_0005986	circPRDM2 	hsa_circ_PRDM2		osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circPRDM2 is up-regulated in doxorubicin-resistant osteosarcoma tissues and cells and promotes DXR resistance, proliferation/colony formation, migration and invasion while inhibiting apoptosis. Mechanistically, it functions as a ceRNA by sponging miR-760 to elevate EZH2, and high circPRDM2 correlates with worse OS and DFS."	0.8034
34104646	BioMed research international	2021	"Identification of Differentially Expressed circRNAs, miRNAs, and Genes in Patients Associated with Cartilaginous Endplate Degeneration."	hsa_circ_0052830		hsa_circ_SDC1	SDC1	cartilaginous endplate degeneration 	MONDO:0005381	bone disorder	up-regulated	Microarray	"hsa_circ_0052830 (from host gene SDC1) was identified by microarray-based differential expression analysis as the most upregulated circRNA in cartilaginous endplate degeneration (CEPD). Its function/mechanism was not experimentally validated; the study suggests DECs may influence CEPD-related processes (inflammation, ECM metabolism, chondrocyte apoptosis/growth) possibly via regulating host genes."	0.1768
34108451	Cell death & disease	2021	CircC16orf62 promotes hepatocellular carcinoma progression through the miR-138-5p/PTK2/AKT axis.		CircC16orf62 	hsa_circ_C16orf62	C16orf62	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"CircC16orf62 is up-regulated in HCC and promotes malignant phenotypes (proliferation, invasion/migration, and aerobic glycolysis) and tumor growth. Mechanistically, it localizes mainly in the cytoplasm and acts as a ceRNA by sponging miR-138-5p to increase PTK2, thereby activating the AKT/mTOR pathway. High expression is associated with worse prognosis in HCC."	0.8834
34109199	Frontiers in medicine	2021	Exosomal Circular RNA RNA-seq Profiling and the Carcinogenic Role of Exosomal circ-CYP24A1 in Cutaneous Squamous Cell Carcinoma.		circ-CYP24A1	hsa_circ_CYP24A1	CYP24A1	cutaneous squamous cell carcinoma 	MONDO:0002529	skin squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"Exosomal circ-CYP24A1 is up-regulated in cSCC patient plasma. Silencing circ-CYP24A1 in exosomes suppresses malignant behaviors (reduced proliferation/migration/invasion and increased apoptosis) in cSCC cells and is associated with decreased CDS2, MAVS and SOGA1 expression."	0.7283
34110683	The Kaohsiung journal of medical sciences	2021	Differentially expressed circRNA and functional pathways in the hippocampus of epileptic mice based on next-generation sequencing.	mmu_circ_0000230	mm9_circ_008777			epilepsy 	MONDO:0005027	epilepsy	up-regulated	RT-qPCR; RNA-seq	"In a pilocarpine-induced acute epilepsy mouse model, mm9_circ_008777 was identified by sequencing as up-regulated in hippocampus and its increased expression was confirmed by RT-qPCR. The study constructed a predicted circRNA_miRNA_mRNA ceRNA network and suggested this circRNA may participate in epilepsy-related pathways (e.g., ErbB and VEGF) and serve as a potential diagnostic biomarker."	0.3684
34110683	The Kaohsiung journal of medical sciences	2021	Differentially expressed circRNA and functional pathways in the hippocampus of epileptic mice based on next-generation sequencing.	mmu_circ_0000872	mm9_circ_004424			epilepsy 	MONDO:0005027	epilepsy	up-regulated	RT-qPCR; RNA-seq	"In a pilocarpine-induced acute epilepsy mouse model, mm9_circ_004424 was identified by sequencing as up-regulated in hippocampus and its increased expression was confirmed by RT-qPCR. The study predicted a circRNA_miRNA_mRNA ceRNA network and inferred involvement in epilepsy-related pathways (e.g., ErbB and VEGF), suggesting potential diagnostic biomarker value."	0.3684
34112159	Cancer cell international	2021	CircRNA NALCN acts as an miR-493-3p sponge to regulate PTEN expression and inhibit glioma progression.	hsa_circ_0099761	circNALCN 	hsa_circ_NALCN	NALCN	glioma 	MONDO:0021042	glioma	down-regulated	RT-qPCR; RNA-seq	"circNALCN (hsa_circ_0099761), derived from NALCN, is down-regulated in glioma tissues and cell lines and is associated with higher WHO grade and worse overall survival. It mainly localizes to the cytoplasm and suppresses glioma cell proliferation and migration by acting as a ceRNA sponge for miR-493-3p, thereby de-repressing PTEN expression (circNALCN/miR-493-3p/PTEN axis)."	0.8502
34112238	Journal of experimental & clinical cancer research : CR	2021	CircPVT1 promotes proliferation of lung squamous cell carcinoma by binding to miR-30d/e.		circPVT1 	hsa_circ_PVT1	PVT1	lung squamous cell carcinoma 	MONDO:0005097	squamous cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"circPVT1 is up-regulated in LUSC tissues/serum/cell lines and promotes LUSC proliferation and xenograft tumor growth. Mechanistically, HuR upregulates circPVT1, which sponges miR-30d/miR-30e to de-repress CCNF, contributing to poor prognosis and potential diagnostic value."	0.8226
34113391	Oncology letters	2021	circMTO1 sponges microRNA-219a-5p to enhance gallbladder cancer progression via the TGF-beta/Smad and EGFR pathways.		circMTO1 	hsa_circ_MTO1	MTO1	gallbladder cancer 	MONDO:0005411	gallbladder cancer	up-regulated	RT-qPCR; RNA-seq	"In gallbladder cancer, circMTO1 is up-regulated and functions as an oncogenic circRNA. It sponges miR-219a-5p, leading to increased Smad2/Smad4 (TGF-beta/Smad signaling) and EGFR expression, thereby promoting viability/migration and tube formation while suppressing apoptosis; high expression correlates with poorer overall survival and more advanced stage."	0.6111
34113396	Oncology letters	2021	Characterization of the small RNA transcriptomes of cell protrusions and cell bodies of highly metastatic hepatocellular carcinoma cells via RNA sequencing.	hsa_circ_0002029				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0002029 is up-regulated in cell protrusions compared with cell bodies in highly metastatic HCCLM3 hepatocellular carcinoma cells, and its differential expression was confirmed by RT-qPCR consistent with RNA-seq results. The study treats it as a candidate circRNA potentially associated with invasion/metastasis-related protrusion biology, without validating a specific mechanistic axis."	0.1904
34113396	Oncology letters	2021	Characterization of the small RNA transcriptomes of cell protrusions and cell bodies of highly metastatic hepatocellular carcinoma cells via RNA sequencing.	hsa_circ_0002100				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0002100 is up-regulated in cell protrusions compared with cell bodies in highly metastatic HCCLM3 hepatocellular carcinoma cells, and its differential expression was confirmed by RT-qPCR consistent with RNA-seq results. It is presented as a candidate circRNA potentially involved in protrusion-associated invasion/metastasis biology, without an experimentally validated mechanistic axis in this study."	0.1904
34113396	Oncology letters	2021	Characterization of the small RNA transcriptomes of cell protrusions and cell bodies of highly metastatic hepatocellular carcinoma cells via RNA sequencing.	hsa_circ_0007429				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0007429 is down-regulated in cell protrusions compared with cell bodies in highly metastatic HCCLM3 hepatocellular carcinoma cells, validated by RT-qPCR with results consistent with RNA-seq. It is a candidate circRNA potentially linked to protrusion-associated invasion/metastasis biology, without a validated mechanistic axis in this study."	0.1904
34113396	Oncology letters	2021	Characterization of the small RNA transcriptomes of cell protrusions and cell bodies of highly metastatic hepatocellular carcinoma cells via RNA sequencing.	hsa_circ_0059580				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0059580 is down-regulated in cell protrusions compared with cell bodies in highly metastatic HCCLM3 hepatocellular carcinoma cells, supported by RNA-seq and verified by PCR/RT-qPCR with concordant direction. It is treated as a candidate circRNA potentially linked to invasion/metastasis-associated protrusion biology, without a validated mechanistic axis in this study."	0.1904
34113396	Oncology letters	2021	Characterization of the small RNA transcriptomes of cell protrusions and cell bodies of highly metastatic hepatocellular carcinoma cells via RNA sequencing.	hsa_circ_0067475				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0067475 is down-regulated in cell protrusions compared with cell bodies in highly metastatic HCCLM3 hepatocellular carcinoma cells, supported by RNA-seq and confirmed by PCR/RT-qPCR with concordant direction. It is a candidate circRNA potentially related to invasion/metastasis-associated protrusion biology, without a validated mechanistic axis in this study."	0.1904
34116030	Gastroenterology	2021	Circular RNA CircHIPK3 Promotes Homeostasis of the Intestinal Epithelium by Reducing MicroRNA 29b Function.		circHIPK3	hsa_circ_HIPK3	HIPK3	inflammatory bowel diseases 	MONDO:0005265	inflammatory bowel disease	down-regulated	RT-qPCR; Microarray	"circHIPK3 is reduced in human intestinal mucosa from IBD and sepsis patients, and it promotes intestinal epithelial wound repair and epithelial renewal. Mechanistically, it acts as a miR-29b sponge to relieve miR-29b-mediated repression of targets such as Rac1, Cdc42 and cyclin B1, supporting migration/proliferation during restitution."	0.7726
34116677	Molecular cancer	2021	The circACTN4 interacts with FUBP1 to promote tumorigenesis and progression of breast cancer by regulating the expression of proto-oncogene MYC.	hsa_circ_0050900	circACTN4	hsa_circ_ACTN4	ACTN4	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; ISH; Microarray	"circACTN4 (hsa_circ_0050900), derived from ACTN4, is up-regulated in breast cancer tissues/cells and associates with advanced stage and poor prognosis. It localizes mainly in the nucleus and promotes proliferation, invasion and metastasis by binding FUBP1, blocking FIR-FUBP1 interaction, and activating MYC transcription; USF2 enhances circACTN4 biogenesis."	0.9058
34117688	Journal of cellular and molecular medicine	2022	Circular RNA circFOXO3 regulates KDM2A by targeting miR-214 to promote tumor growth and metastasis in oral squamous cell carcinoma.	hsa_circ_0006404	circFOXO3	hsa_circ_FOXO3	FOXO3	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circFOXO3 is up-regulated in OSCC tissues and cell lines and promotes invasion and proliferation. Mechanistically, it acts as a ceRNA by sponging miR-214, relieving repression of KDM2A and thereby promoting OSCC progression, with in vivo xenograft evidence."	0.779
34120145	Cell death discovery	2021	Carcinoma-associated fibroblasts derived exosomes modulate breast cancer cell stemness through exonic circHIF1A by miR-580-5p in hypoxic stress.	hsa_circ_0032138	circHIF1A 	hsa_circ_HIF1A	HIF1A	breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; ISH; Microarray	"In breast cancer, exosomal circHIF1A derived from hypoxic CAFs is upregulated and transferred into cancer cells, where it mainly localizes to the cytoplasm. It promotes proliferation and stemness by sponging miR-580-5p and thereby increasing CD44 expression, with supportive in vivo xenograft evidence."	0.8551
34120606	Cancer cell international	2021	Exosomal circRNA as a novel potential therapeutic target for multiple myeloma-related myocardial damage.		circ-G042080 			multiple myeloma 	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR; RNA-seq	"circ-G042080 is up-regulated in serum exosomes from MM patients and correlates with MM-related myocardial damage severity. It likely sponges hsa-miR-4268 to increase TLR4 and activate Toll-like receptor signaling, promoting autophagy and cardiomyocyte injury; higher levels predict poorer survival."	0.7617
34123587	PeerJ	2021	Key circular RNAs identified in male osteoporosis patients by whole transcriptome sequencing.	hsa_circ_0042409	circ_0042409			osteoporosis 	MONDO:0005298	osteoporosis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0042409 is up-regulated in peripheral blood mononuclear cells from male osteoporosis patients. It is proposed to act as a ceRNA that sponges hsa-miR-195-5p to increase KLC1 expression, thereby promoting osteoporosis pathogenesis and potentially serving as a biomarker/target."	0.4032
34124144	Frontiers in molecular biosciences	2021	Gene Expression Profiles of Circular RNAs and MicroRNAs in Chronic Rhinosinusitis With Nasal Polyps.		hsa-circ-0031593			Chronic rhinosinusitis with nasal polyps 	MONDO:0006031	chronic rhinosinusitis	up-regulated	RT-qPCR; RNA-seq; Microarray	"hsa-circ-0031593 is up-regulated in CRSwNP nasal tissues versus controls and shows strong diagnostic/functional value by ROC analysis. It is included in circRNA_miRNA co-expression networks, suggesting potential miRNA-sponge-related regulatory roles, though no specific downstream target is experimentally validated in this study."	0.5267
34124144	Frontiers in molecular biosciences	2021	Gene Expression Profiles of Circular RNAs and MicroRNAs in Chronic Rhinosinusitis With Nasal Polyps.		hsa-circ-0031594			Chronic rhinosinusitis with nasal polyps 	MONDO:0006031	chronic rhinosinusitis	up-regulated	RT-qPCR; RNA-seq; Microarray	"hsa-circ-0031594 is up-regulated in CRSwNP versus control nasal tissues and was validated by qRT-PCR in expanded cohorts. It shows good diagnostic/functional value by ROC analysis (AUC 0.8176), but the study does not provide a specific mechanistic axis for this circRNA."	0.4915
34124372	Open life sciences	2021	Identification of circRNA circ-CSPP1 as a potent driver of colorectal cancer by directly targeting the miR-431/LASP1 axis.	hsa_circ_0001806	circ-CSPP1	hsa_circ_CSPP1	CSPP1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ-CSPP1 is up-regulated in colorectal cancer and acts as an oncogenic circRNA. It promotes CRC cell proliferation, migration and invasion and inhibits apoptosis, at least partly by sponging miR-431 to increase LASP1 expression, and it enhances xenograft tumor growth in vivo."	0.8071
34124974	Annals of medicine	2021	Hsa_circ_0042823 accelerates cancer progression via miR-877-5p/FOXM1 axis in laryngeal squamous cell carcinoma.	hsa_circ_0042823				laryngeal squamous cell carcinoma 	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR	"hsa_circ_0042823 is up-regulated in LSCC cell lines and functions as an oncogenic circRNA. It sponges miR-877-5p to increase FOXM1 expression, thereby promoting proliferation, migration, invasion, and xenograft tumor growth."	0.528
34126925	BMC genomics	2021	Ovary-derived circular RNAs profile analysis during the onset of puberty in gilts.		circ 7:65198472_65198799			pubertal transition 	MONDO:0024990	swine disease	dysregulated	RT-qPCR; RNA-seq	"This circRNA is significantly differentially expressed across pubertal stages in gilt ovaries, with RT-qPCR results consistent with RNA-seq."	0.3401
34126925	BMC genomics	2021	Ovary-derived circular RNAs profile analysis during the onset of puberty in gilts.		circ 16:44513270_44525240			pubertal transition 	MONDO:0024990	swine disease	dysregulated	RT-qPCR; RNA-seq	This circRNA is significantly differentially expressed across pubertal stages in gilt ovaries and is supported by RT-qPCR consistent with RNA-seq.	0.3401
34126925	BMC genomics	2021	Ovary-derived circular RNAs profile analysis during the onset of puberty in gilts.		circ 2:95657661_95677798			pubertal transition 	MONDO:0024990	swine disease	dysregulated	RT-qPCR; RNA-seq	"This circRNA shows significant differential expression across pubertal stages in gilt ovaries, validated by RT-qPCR in agreement with RNA-seq."	0.3401
34126925	BMC genomics	2021	Ovary-derived circular RNAs profile analysis during the onset of puberty in gilts.		circ 9:131264261_131268491			pubertal transition 	MONDO:0024990	swine disease	down-regulated	RT-qPCR; RNA-seq	"circ 9:131264261_131268491 is down-regulated during pubertal transition (pre- vs post-puberty) in gilt ovaries. It is predicted to interact with ssc-miR-320/ssc-miR-582-5p/ssc-miR-493-3p and potentially affect target genes including FSTL4, GAS2 and FSHR via a ceRNA-like mechanism."	0.3858
34126925	BMC genomics	2021	Ovary-derived circular RNAs profile analysis during the onset of puberty in gilts.		circ 15:76166995|76177857			pubertal transition 	MONDO:0024990	swine disease	dysregulated	RT-qPCR; RNA-seq	"This circRNA is significantly differentially expressed across pubertal stages in gilt ovaries, with RT-qPCR validation consistent with RNA-seq."	0.3401
34126925	BMC genomics	2021	Ovary-derived circular RNAs profile analysis during the onset of puberty in gilts.		circ 1:121217326|121230821			pubertal transition 	MONDO:0024990	swine disease	dysregulated	RT-qPCR; RNA-seq	"This circRNA is significantly differentially expressed across pubertal stages in gilt ovaries, and RT-qPCR confirms the RNA-seq trend."	0.3401
34126925	BMC genomics	2021	Ovary-derived circular RNAs profile analysis during the onset of puberty in gilts.		circ 13:82256891|82274534			pubertal transition 	MONDO:0024990	swine disease	dysregulated	RT-qPCR; RNA-seq	This circRNA is significantly differentially expressed during pubertal transition in gilt ovaries and is supported by RT-qPCR consistent with RNA-seq.	0.3401
34126925	BMC genomics	2021	Ovary-derived circular RNAs profile analysis during the onset of puberty in gilts.		circ 2:151068704_151069641			pubertal transition 	MONDO:0024990	swine disease	unknown	RT-qPCR; RNA-seq	This circRNA was used as an example of an insignificantly differentially expressed circRNA; RT-qPCR indicated no significant expression change across stages.	0.3401
34126989	Cancer cell international	2021	Circular RNA hsa_circ_0044234 as distinct molecular signature of triple negative breast cancer: a potential regulator of GATA3.	hsa_circ_0044234	circ_0044234 	hsa_circ_CDC27	CDC27	triple negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0044234 (a CDC27-derived circRNA) is down-regulated in TNBC compared with non-TNBC tumors and luminal cell lines. It is proposed to act in a ceRNA network by sponging miR-135b-5p to relieve repression of GATA3, and it shows potential diagnostic (ROC) and prognostic (DFS trend) value in breast cancer/TNBC."	0.6895
34127015	World journal of surgical oncology	2021	CircASXL1 knockdown represses the progression of colorectal cancer by downregulating GRIK3 expression by sponging miR-1205.	hsa_circ_0001136	circASXL1 	hsa_circ_ASXL1	ASXL1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circASXL1 is up-regulated in colorectal cancer and promotes malignant phenotypes (proliferation/colony formation, migration, invasion) while inhibiting G0/G1 arrest and apoptosis. Mechanistically, it functions as a ceRNA that sponges miR-1205 to increase GRIK3 expression, and circASXL1 knockdown suppresses xenograft tumor growth."	0.7892
34127806	Cell death and differentiation	2021	Targeting androgen receptor (AR) with antiandrogen Enzalutamide increases prostate cancer cell invasion yet decreases bladder cancer cell invasion via differentially altering the AR/circRNA-ARC1/miR-125b-2-3p or miR-4736/PPARgamma/MMP-9 signals.		circRNA-ARC1 	hsa_circ_AR	AR	prostate cancer 	MONDO:0008315	prostate cancer	dysregulated	RT-qPCR	"circRNA-ARC1 is an AR-locus-derived circRNA whose level is differentially regulated by AR/Enzalutamide in prostate vs bladder cancer cells. It promotes invasion/metastasis by sponging miR-125b-2-3p and miR-4736, thereby modulating PPARGC1B/PDK1 and downstream PPARgamma-driven MMP-9 signaling; knocking down circRNA-ARC1 suppresses Enz-induced prostate cancer metastasis in vivo."	0.7551
34132637	eLife	2021	circPTPN12/miR-21-5 p/_Np63alpha pathway contributes to human endometrial fibrosis.	hsa_circ_0003764	circPTPN12	hsa_circ_PTPN12	PTPN12	endometrium fibrosis 	MONDO:0000931	endometrial disorder	up-regulated	RT-qPCR; ISH; RNA-seq	"circPTPN12 (hsa_circ_0003764), derived from the PTPN12 gene, is up-regulated in fibrotic endometrium/IUA and mainly expressed in EECs. It localizes predominantly to the cytoplasm and acts as a ceRNA sponge for miR-21_5 p, lowering miR-21_5 p activity to de-repress deltaNp63alpha, thereby promoting EEC-EMT and endometrial fibrosis; miR-21_5 p supplementation counteracts these effects in vivo."	0.8558
34133325	Aging	2021	Identification of RNA binding protein interacting with circular RNA and hub candidate network for hepatocellular carcinoma.	hsa_circ_0004913				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	hsa_circ_0004913 is down-regulated in HCC and experimentally binds the RBP TARDBP in HCC cells (RIP and RNA pull-down). The paper discusses that hsa_circ_0004913 may have an anticarcinogenic role and could potentially counteract TARDBP-driven HCC progression; it is also reported to be linked to a miR-184/INPPL1 regulatory relationship.	0.5281
34135596	OncoTargets and therapy	2021	Construction and Analysis of a circRNA-Mediated ceRNA Network in Lung Adenocarcinoma.	hsa_circ_0072088	hsa_circRNA_103809			lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0072088 is up-regulated in LUAD tissues versus adjacent normal tissues (microarray and qRT-PCR). The study constructed a predicted ceRNA network in which hsa_circ_0072088 may sponge hsa-miR-532-3p and hsa-miR-942-5p to influence multiple downstream mRNAs (including IGF2BP3, MKI67, CD79A, and ABAT)."	0.4032
34135597	OncoTargets and therapy	2021	"circHIPK3 (hsa_circ_0000284) Promotes Proliferation, Migration and Invasion of Breast Cancer Cells via miR-326."	hsa_circ_0000284	circHIPK3 	hsa_circ_HIPK3	HIPK3	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circHIPK3 (hsa_circ_0000284) is up-regulated in breast cancer tissues/cells and mainly localized in the cytoplasm. It promotes proliferation, migration, invasion, EMT and tumor growth while inhibiting apoptosis, largely by sponging miR-326 (supported by luciferase and Ago2-RIP), thereby modulating apoptosis- and EMT-related proteins (e.g., Bcl-2, Bax, cleaved Caspase-3; E-cadherin, N-cadherin, vimentin)."	0.8175
34135635	Cancer management and research	2021	CircRNA CircRIMS is Overexpressed in Esophageal Squamous Cell Carcinoma and Downregulate miR-613 Through Methylation to Increase Cell Proliferation.		CircRNA CircRIMS 			esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"CircRIMS is up-regulated in ESCC tissues and promotes ESCC cell proliferation and xenograft tumor growth. Mechanistically, CircRIMS interacts with miR-613 and suppresses miR-613 expression by increasing methylation of the miR-613 gene, associated with increased DNMT1, leading to a poor-prognosis clinical association."	0.7548
34136401	Frontiers in oncology	2021	CircKEAP1 Suppresses the Progression of Lung Adenocarcinoma via the miR-141-3p/KEAP1/NRF2 Axis.		circKEAP1 	hsa_circ_KEAP1	KEAP1	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; Northern Blot; Microarray	"circKEAP1 (hsa_circRNA_102442) is down-regulated in LUAD and functions as a tumor suppressor. It sponges miR-141-3p to de-repress KEAP1, thereby modulating the KEAP1/NRF2/HDAC4 signaling cascade and inhibiting LUAD cell proliferation/migration and xenograft growth. Low circKEAP1 expression is associated with unfavorable prognosis in LUAD patients."	0.8942
34136582	Journal of immunology research	2021	Circular RNA hsa_circ_0000511 Improves Epithelial Mesenchymal Transition of Cervical Cancer by Regulating hsa-mir-296-5p/HMGA1.	hsa_circ_0000511	circ_0000511 	hsa_circ_RPPH1	RPPH1	cervical cancer	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"hsa_circ_0000511 is up-regulated in cervical cancer cell lines and is mainly localized in the cytoplasm. It functions as a ceRNA by sponging hsa-miR-296-5p to modulate HMGA1 and EMT-related markers (E-cadherin/N-cadherin), thereby influencing proliferation, migration, and invasion; the study also validates effects in a nude-mouse xenograft model."	0.762
34140036	Journal of orthopaedic surgery and research	2021	Circ-SPG11 knockdown hampers IL-1beta-induced osteoarthritis progression via targeting miR-337-3p/ADAMTS5.		circ-SPG11	hsa_circ_SPG11	SPG11	osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circ-SPG11 is up-regulated in osteoarthritis cartilage and IL-1beta-treated CHON-001 cells and mainly localizes to the cytoplasm. It promotes OA-like phenotypes by sponging miR-337-3p to increase ADAMTS5, leading to enhanced ECM degradation and increased inflammatory cytokine production, while reducing viability and increasing apoptosis."	0.7785
34145224	Cell death & disease	2021	Circ_0008542 in osteoblast exosomes promotes osteoclast-induced bone resorption through m6A methylation.	mmu_circ_0008542	circ_0008542	mmu_circ_Rrp15	Rrp15	osseointegration failure 	MONDO:0005381	bone disorder	up-regulated	RT-qPCR; RNA-seq	"circ_0008542 is enriched/upregulated in osteoblast (MC3T3-E1) exosomes after prolonged tensile stimulation and promotes RANKL-induced osteoclast differentiation and bone resorption. Mechanistically, it acts as a miR-185-5p sponge to increase RANK (Tnfrsf11a) expression, and this ceRNA effect depends on METTL3/ALKBH5-regulated m6A modification (functional site at 1956 bp)."	0.8152
34145797	"Immunity, inflammation and disease"	2021	"CircZNF124 regulates cell proliferation, leucine uptake, migration and invasion by miR-199b-5p/SLC7A5 pathway in endometrial cancer."	hsa_circ_0005667	circZNF124 	hsa_circ_ZNF124	ZNF124	endometrial cancer 	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR	"CircZNF124 is up-regulated in endometrial cancer tissues and cell lines and is associated with higher FIGO stage and lymph node metastasis. Functionally, circZNF124 promotes proliferation, leucine uptake, migration/invasion, and xenograft tumor growth by sponging miR-199b-5p to de-repress SLC7A5."	0.7751
34150336	Translational neuroscience	2021	circ_0030018 promotes glioma proliferation and metastasis.	hsa_circ_0030018	circ_0030018	hsa_circ_POSTN	POSTN	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ_0030018 is up-regulated in glioma tissues and glioma cell lines. It promotes glioma malignant phenotypes (proliferation, migration/invasion and in vivo tumor growth) and suppresses apoptosis by sponging miR-194-5p to de-repress TRIM44 (circ_0030018/miR-194-5p/TRIM44 axis)."	0.7595
34153004	Aging	2021	Circular RNA circKIF4A facilitates the malignant progression and suppresses ferroptosis by sponging miR-1231 and upregulating GPX4 in papillary thyroid cancer.		circKIF4A	hsa_circ_KIF4A	KIF4A	papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circKIF4A is up-regulated in papillary thyroid cancer and promotes tumor cell proliferation and migration/metastasis. Mechanistically, it acts as a ceRNA sponge for miR-1231 to relieve repression of GPX4, thereby increasing GPX4 and suppressing ferroptosis."	0.7983
34154526	BMC cardiovascular disorders	2021	Circular RNA mmu_circ_0005019 inhibits fibrosis of cardiac fibroblasts and reverses electrical remodeling of cardiomyocytes.	mmu_circ_0005019				atrial fibrillation 	MONDO:0004981	atrial fibrillation	unknown	RT-qPCR	"In mouse cardiac fibroblasts, mmu_circ_0005019 suppresses proliferation and migration, suggesting an anti-fibrotic effect. In HL-1 atrial myocytes, it increases expression of ion-channel-related genes (including Kcnn3) and is proposed to counter electrical remodeling in AF via a ceRNA mechanism where mmu_circ_0005019 sponges miR-499-5p to de-repress Kcnn3."	0.7166
34154607	Journal of orthopaedic surgery and research	2021	CircMAPK9 promotes the progression of fibroblast-like synoviocytes in rheumatoid arthritis via the miR-140-3p/PPM1A axis.	hsa_circ_0001566	circMAPK9	hsa_circ_MAPK9	MAPK9	Rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"circMAPK9 is up-regulated in RA synovial tissues and RA-FLSs. It promotes RA-FLS proliferation, migration/invasion and inflammatory cytokine production while inhibiting apoptosis by acting as a ceRNA sponge for miR-140-3p to increase PPM1A expression."	0.6971
34158077	World journal of surgical oncology	2021	CircLRP6 contributes to prostate cancer growth and metastasis by binding to miR-330-5p to up-regulate NRBP1.	hsa_circ_0000378	circLRP6 	hsa_circ_LRP6	LRP6	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; ISH; Microarray	"circLRP6 is up-regulated in prostate cancer tissues and cell lines and promotes proliferation and metastatic phenotypes (invasion, migration, EMT) while inhibiting apoptosis. Mechanistically, circLRP6 sponges miR-330-5p to relieve repression of NRBP1, forming a circLRP6/miR-330-5p/NRBP1 ceRNA axis that also drives tumor growth and EMT in a PC3 xenograft model."	0.8557
34158864	Theranostics	2021	Circular RNA circRHOBTB3 represses metastasis by regulating the HuR-mediated mRNA stability of PTBP1 in colorectal cancer.	hsa_circ_0007444	circRHOBTB3	hsa_circ_RHOBTB3	RHOBTB3	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"circRHOBTB3 is down-regulated in colorectal cancer and functions as a metastasis suppressor. It binds HuR and promotes beta-Trcp1-mediated ubiquitination/proteasomal degradation of HuR, reducing HuR-stabilized PTBP1 mRNA and thereby inhibiting EMT-associated migration/invasion and lung metastasis."	0.8747
34162830	Cell death & disease	2021	Circular RNA hsa_circ_0110389 promotes gastric cancer progression through upregulating SORT1 via sponging miR-127-5p and miR-136-5p.	hsa_circ_0110389		hsa_circ_SORT1	SORT1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0110389 is up-regulated in gastric cancer tissues/cells and is mainly cytoplasmic. It promotes GC proliferation, migration, invasion and xenograft growth by sponging miR-127-5p and miR-136-5p, thereby increasing SORT1 expression and influencing autophagy-related proteins."	0.8847
34163248	Cancer management and research	2021	Circular RNA 0014715 Facilitates Cell Proliferation and Inhibits Apoptosis in Esophageal Squamous Cell Carcinoma.	hsa_circ_0014715		hsa_circ_CCT3	CCT3	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"circ_0014715 (from host gene CCT3) is up-regulated in ESCC tissues and cell lines. Functional assays show it promotes proliferation, migration and invasion and inhibits apoptosis, with knockdown causing G2-phase arrest. The study only provides bioinformatic predictions of candidate binding miRNAs without mechanistic validation, and suggests potential diagnostic value by ROC analysis."	0.7554
34164494	Annals of translational medicine	2021	CircRNA HIPK3 promotes the progression of oral squamous cell carcinoma through upregulation of the NUPR1/PI3K/AKT pathway by sponging miR-637.		circHIPK3 	hsa_circ_HIPK3	HIPK3	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in OSCC and promotes proliferation, invasion and EMT while inhibiting apoptosis. Mechanistically, it sponges miR-637 to upregulate NUPR1 and activate the PI3K/AKT pathway, and high circHIPK3 indicates poorer survival."	0.8438
34165176	Molecular medicine reports	2021	Circular RNA profiling reveals a potential role of hsa_circ_IPCEF1 in papillary thyroid carcinoma.	hsa_circ_0000277		hsa_circ_PDE3B	PDE3B	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000277 is up-regulated in papillary thyroid carcinoma and was validated in both thyroid tissues and whole blood. Its miRNA response elements were bioinformatically predicted, suggesting potential ceRNA-related regulation, but no dedicated functional mechanism was experimentally validated for this circRNA in this study."	0.4032
34165176	Molecular medicine reports	2021	Circular RNA profiling reveals a potential role of hsa_circ_IPCEF1 in papillary thyroid carcinoma.	hsa_circ_0074530		hsa_circ_CD74	CD74	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circ_0074530 is up-regulated in papillary thyroid carcinoma and was validated in both thyroid tissues and whole blood. This study only provided bioinformatic prediction of its miRNA response elements without experimental functional validation.	0.4032
34165176	Molecular medicine reports	2021	Circular RNA profiling reveals a potential role of hsa_circ_IPCEF1 in papillary thyroid carcinoma.	hsa_circ_0057691		hsa_circ_SATB2	SATB2	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0057691 is up-regulated in papillary thyroid carcinoma and was validated in thyroid tissues and whole blood. The study predicted its miRNA response elements, implying a possible ceRNA-related role, but did not experimentally validate downstream targets or functions."	0.4032
34165176	Molecular medicine reports	2021	Circular RNA profiling reveals a potential role of hsa_circ_IPCEF1 in papillary thyroid carcinoma.	hsa_circ_0020396		hsa_circ_DOCK1	DOCK1	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR; Microarray	hsa_circ_0020396 is down-regulated in papillary thyroid carcinoma and was validated in thyroid tissues and whole blood. The study reported predicted miRNA response elements but did not experimentally validate a specific functional mechanism for this circRNA.	0.4032
34165176	Molecular medicine reports	2021	Circular RNA profiling reveals a potential role of hsa_circ_IPCEF1 in papillary thyroid carcinoma.	hsa_circ_0095448		hsa_circ_SOX6	SOX6	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR; Microarray	hsa_circ_0095448 is down-regulated in papillary thyroid carcinoma and was validated in thyroid tissues and whole blood. The study provided predicted miRNA response elements but no direct functional experiments for this circRNA.	0.4032
34165176	Molecular medicine reports	2021	Circular RNA profiling reveals a potential role of hsa_circ_IPCEF1 in papillary thyroid carcinoma.			hsa_circ_IPCEF1	IPCEF1	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_IPCEF1 is significantly down-regulated in papillary thyroid carcinoma and validated in tissues and whole blood. The study proposes a bioinformatics-based ceRNA model where hsa_circ_IPCEF1 sponges hsa-miR-3619-5p and may regulate cancer-related targets including CASR and CDC25B, with diagnostic potential supported by ROC analysis and association with lymph node metastasis."	0.6556
34165176	Molecular medicine reports	2021	Circular RNA profiling reveals a potential role of hsa_circ_IPCEF1 in papillary thyroid carcinoma.	hsa_circ_0021549		hsa_circ_MPPED2	MPPED2	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0021549 is down-regulated in papillary thyroid carcinoma and validated in tissues and whole blood. It shows diagnostic potential in whole blood based on ROC analysis (AUC 0.8194), while mechanistic roles were only bioinformatically inferred via predicted miRNA response elements."	0.5047
34165822	Journal of clinical laboratory analysis	2021	Down-regulation of hsa_circ_0006470 predicts tumor invasion: A new biomarker of gastric cancer.	hsa_circ_0006470		hsa_circ_MFN2	MFN2	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	hsa_circ_0006470 is significantly down-regulated in gastric cancer tissues and GC cell lines. Its decreased expression is associated with TNM stage and invasion degree and shows diagnostic value for GC (ROC AUC ~0.783).	0.559
34165827	Journal of clinical laboratory analysis	2021	The role of circRNA derived from RUNX2 in the serum of osteoarthritis and its clinical value.	hsa_circ_0005526	circ_RUNX2 	hsa_circ_RUNX2	RUNX2	osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"hsa_circ_0005526 (circ_RUNX2), derived from RUNX2, is up-regulated in OA patient serum and is mainly cytoplasmic in cartilage cells. It sponges miR-498/miR-924/miR-361-3p/miR-665 and is linked to the ECM-receptor interaction pathway; serum circ_RUNX2 shows diagnostic potential for OA (AUC 0.82)."	0.7241
34168116	Cell death & disease	2021	Novel circular RNA circSLIT2 facilitates the aerobic glycolysis of pancreatic ductal adenocarcinoma via miR-510-5p/c-Myc/LDHA axis.	hsa_circ_0009113	circSLIT2	hsa_circ_SLIT2	SLIT2	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circSLIT2 is up-regulated in PDAC and its high expression is associated with poor prognosis. It promotes Warburg-like aerobic glycolysis and proliferation, and enhances tumor growth via a ceRNA mechanism in which circSLIT2 sponges miR-510-5p to increase c-Myc and downstream LDHA transcription."	0.8763
34168916	Molecular therapy. Nucleic acids	2021	circMELK promotes glioblastoma multiforme cell tumorigenesis through the miR-593/EphB2 axis.		circMELK 	hsa_circ_MELK	MELK	glioblastoma multiforme 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR	"circMELK (cMELK), derived from MELK, is up-regulated in glioma/GBM tissues and cells and primarily localizes in the cytoplasm. It promotes GBM mesenchymal transition, migration/invasion and glioma stem cell maintenance. Mechanistically, it functions as a miR-593 sponge to de-repress EphB2, forming a circMELK/miR-593/EphB2 oncogenic axis."	0.891
34168984	Frontiers in oncology	2021	circ0093740 Promotes Tumor Growth and Metastasis by Sponging miR-136/145 and Upregulating DNMT3A in Wilms Tumor.		circ0093740		PCDH15	Wilms tumor 	MONDO:0006058	Wilms tumor	up-regulated	RT-qPCR; Microarray	"circ0093740 is upregulated in Wilms tumor tissues and cell lines and promotes proliferation, migration and metastasis. Mechanistically, it predominantly localizes in the cytoplasm and functions as a ceRNA to sponge miR-136 and miR-145, thereby upregulating DNMT3A (with AGO2/RISC involvement) and facilitating tumor progression."	0.8511
34169652	Journal of cellular and molecular medicine	2021	"Circ_0002984 induces proliferation, migration and inflammation response of VSMCs induced by ox-LDL through miR-326-3p/VAMP3 axis in atherosclerosis."	hsa_circ_0002984	circ_0002984	hsa_circ_UBR4	UBR4	atherosclerosis	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"circ_0002984 is up-regulated in atherosclerosis patient serum and in ox-LDL-treated VSMCs. It promotes VSMC proliferation/viability, cell-cycle progression, migration, and inflammatory cytokine release by sponging miR-326-3p and thereby increasing VAMP3 expression."	0.7591
34169675	The world journal of men's health	2022	Circ_0001686 Promotes Prostate Cancer Progression by Up-Regulating SMAD3/TGFBR2 via miR-411-5p.	hsa_circ_0001686	circ_0001686			prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	"circ_0001686 is up-regulated in prostate cancer tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion). Mechanistically, it interacts with miR-411-5p and increases SMAD3/TGFBR2 expression, implicating activation of the TGF-beta/SMAD axis."	0.6829
34172072	Molecular cancer	2021	"Circ3823 contributes to growth, metastasis and angiogenesis of colorectal cancer: involvement of miR-30c-5p/TCF7 axis."	hsa_circ_0001821	circ3823	hsa_circ_PVT1	PVT1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circ3823 (hsa_circ_0001821), derived from PVT1, is up-regulated in CRC tissues and patient serum and is associated with worse prognosis and diagnostic potential. It promotes CRC proliferation, migration/invasion, metastasis and angiogenesis by sponging miR-30c-5p to increase TCF7, thereby upregulating MYC and CCND1 and activating Wnt signaling. The study also reports m6A modification on circ3823 linked to its degradation regulation."	0.9043
34173324	Journal of cellular and molecular medicine	2021	CircPLCE1 facilitates the malignant progression of colorectal cancer by repressing the SRSF2-dependent PLCE1 pre-RNA splicing.	hsa_circ_0019230	circPLCE1	hsa_circ_PLCE1	PLCE1	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"circPLCE1 (hsa_circ_0019230), derived from PLCE1, is down-regulated in CRC tissues but functions as a tumour promoter. It mainly localizes to the nucleus and binds SRSF2 to repress SRSF2-dependent PLCE1 pre-RNA splicing, reducing PLCE1 mRNA/protein and promoting malignant phenotypes and xenograft growth."	0.7536
34174955	Diabetology & metabolic syndrome	2021	Circ-ACTR2 aggravates the high glucose-induced cell dysfunction of human renal mesangial cells through mediating the miR-205-5p/HMGA2 axis in diabetic nephropathy.			hsa_circ_ACTR2	ACTR2	Diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"circ-ACTR2 is up-regulated in DN kidney tissues and in HG-treated HRMCs, where it promotes mesangial cell injury (proliferation, inflammation, ECM deposition, oxidative stress). Mechanistically, it functions as a ceRNA by sponging miR-205-5p, thereby increasing HMGA2 expression and aggravating HG-induced dysfunction."	0.762
34178027	Frontiers in genetics	2021	Circ_0040039 May Aggravate Intervertebral Disk Degeneration by Regulating the MiR-874-3p-ESR1 Pathway.	hsa_circ_0040039	circ_0040039	hsa_circ_SNTB2	syntrophin beta2	intervertebral disk degeneration 	MONDO:0011385	intervertebral disk degenerative disorder	up-regulated	RT-qPCR; Microarray	"circ_0040039 is upregulated in IDD and, in NPCs, increases miR-874-3p while repressing ESR1, consistent with a miRNA-stabilization model. Functionally, circ_0040039 promotes NPC apoptosis and inhibits NPC growth, suggesting it aggravates IDD through the miR-874-3p_ESR1 axis."	0.5008
34180136	Journal of cellular and molecular medicine	2021	Identification and characterization of N6-methyladenosine modification of circRNAs in glioblastoma.		circ-DTHD1	hsa_circ_DTHD1	DTHD1	glioblastoma 	MONDO:0018177	glioblastoma	unknown	RT-qPCR; RNA-seq	"circ-DTHD1 was selected as a hypermethylated/high-expression candidate circRNA in GBM, but its MeRIP-qPCR validation result was inconsistent with sequencing, so its disease-associated change is not reliably supported in this study."	0.5135
34180753	Bioengineered	2021	CircRASSF2 acts as a prognostic factor and promotes breast cancer progression by modulating miR-1205/HOXA1 axis.	hsa_circ_0059354	circRASSF2	hsa_circ_RASSF2	RASSF2	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circRASSF2 is up-regulated in breast cancer tissues and patient serum and is associated with metastasis, advanced clinicopathologic features, and poor OS/PFS. Functionally, circRASSF2 promotes proliferation, colony formation, migration, and invasion and suppresses apoptosis in BC cells. Mechanistically, it acts as a ceRNA that sponges miR-1205 to increase HOXA1 expression (circRASSF2/miR-1205/HOXA1 axis)."	0.7408
34182814	The Journal of international medical research	2021	Potential mechanism of circRNA_000585 in cholangiocarcinoma.	hsa_circ_0000515	circRNA_000585 			cholangiocarcinoma 	MONDO:0019087	cholangiocarcinoma	up-regulated	RT-qPCR; Microarray	"circRNA_000585 (hsa_circ_0000515) is upregulated in cholangiocarcinoma tumor tissue versus paired para-cancer tissue. The study proposes a circRNA_000585_miR-615-5p_AMOT_YAP regulatory pathway based on bioinformatic prediction and RT-qPCR expression patterns of miR-615-5p, AMOT, and YAP."	0.5135
34182990	Cancer cell international	2021	CircRNA_100290 promotes GC cell proliferation and invasion via the miR-29b-3p/ITGA11 axis and is regulated by EIF4A3.		circRNA_100290 	hsa_circ_SLC30A7	SLC30A7	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circRNA_100290 is upregulated in gastric cancer tissues and cell lines and promotes proliferation, migration, invasion, cell-cycle progression, and EMT. It acts as a ceRNA by sponging miR-29b-3p to upregulate ITGA11, while EIF4A3 binds flanking regions to inhibit circRNA_100290 formation."	0.705
34183076	"Journal of biological research (Thessalonike, Greece)"	2021	Sevoflurane inhibits malignant progression of colorectal cancer via hsa_circ_0000231-mediated miR-622.	hsa_circ_0000231	circ_0000231			colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"hsa_circ_0000231 is up-regulated in colorectal cancer tissues/cells and promotes malignant behaviors (proliferation, migration/invasion) while inhibiting apoptosis. Mechanistically, it sponges miR-622 (validated by luciferase and Ago2-RIP), and its overexpression counteracts sevoflurane-induced suppression of CRC progression and tumor growth; high expression predicts poorer survival."	0.7858
34183642	Cell death & disease	2021	Circ-0005105 activates COL11A1 by targeting miR-20a-3p to promote pancreatic ductal adenocarcinoma progression.		circ-0005105	hsa_circ_SEC24A	SEC24A	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circ-0005105 is up-regulated in PDAC tissues and cell lines and promotes proliferation, invasion/migration, tumor growth and metastasis. It functions as a ceRNA by sponging miR-20a-3p to upregulate COL11A1, thereby activating EMT, and high circ-0005105 predicts poor survival in PDAC."	0.8855
34184075	Molecular medicine reports	2021	"Interference with circRNA DOCK1 inhibits hepatocellular carcinoma cell proliferation, invasion and migration by regulating the miR-654-5p/SMAD2 axis."		circRNA DOCK1 	hsa_circ_DOCK1	DOCK1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circRNA DOCK1 is up-regulated in hepatocellular carcinoma cell lines and mainly localized in the cytoplasm. It promotes HCC cell proliferation, migration and invasion by sponging miR-654-5p, thereby relieving miR-654-5p-mediated repression of SMAD2 (circRNA DOCK1/miR-654-5p/SMAD2 axis)."	0.5699
34185205	Annals of surgical oncology	2021	Significance of Circular FAT1 as a Prognostic Factor and Tumor Suppressor for Esophageal Squamous Cell Carcinoma.	hsa_circ_0001461	circFAT1 	hsa_circ_FAT1	FAT1	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	RT-qPCR	"circFAT1 is down-regulated in ESCC tissues and cell lines and acts as a tumor suppressor by inhibiting migration and invasion. Mechanistically, circFAT1 may sponge miR-548g (knockdown increases miR-548g), and higher tumor circFAT1 expression predicts better RFS/CSS in ESCC patients."	0.728
34187598	Infectious agents and cancer	2021	Circular RNA circRHOBTB3 is downregulated in hepatocellular carcinoma and suppresses cell proliferation by inhibiting miR-18a maturation.		circRHOBTB3	hsa_circ_RHOBTB3	RHOBTB3	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	circRHOBTB3 is down-regulated in hepatocellular carcinoma tissues and HCC cell lines. Its overexpression suppresses HCC cell proliferation by reducing mature miR-18a levels through inhibition of miR-18a maturation (without changing miR-18a precursor).	0.4862
34188490	OncoTargets and therapy	2021	Expression Profiles of Circular RNAs in Human Papillary Thyroid Carcinoma Based on RNA Deep Sequencing.		chr4: 25665378_25667298+	hsa_circ_SLC34A2	SLC34A2	Papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; RNA-seq	chr4: 25665378_25667298+ (host gene SLC34A2) is up-regulated in papillary thyroid carcinoma and is proposed as a diagnostic biomarker based on RT-qPCR validation and ROC analysis. Its mechanistic involvement is only predicted via a circRNA_miRNA_mRNA (ceRNA) network without direct experimental confirmation.	0.5047
34188490	OncoTargets and therapy	2021	Expression Profiles of Circular RNAs in Human Papillary Thyroid Carcinoma Based on RNA Deep Sequencing.	hsa_circ_0128482	chr5: 161330883_161336769-	hsa_circ_GABRB2	GABRB2	Papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; RNA-seq	chr5: 161330883_161336769- (hsa_circ_0128482; host gene GABRB2) is up-regulated in papillary thyroid carcinoma and shows diagnostic value in ROC analyses after RT-qPCR validation in clinical tissue pairs. Mechanistic roles were only computationally predicted via circRNA_miRNA_mRNA network analysis.	0.5047
34188490	OncoTargets and therapy	2021	Expression Profiles of Circular RNAs in Human Papillary Thyroid Carcinoma Based on RNA Deep Sequencing.	hsa_circ_0010023	chr1: 12578718_12579412-	hsa_circ_DHRS3	DHRS3	Papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; RNA-seq	chr1: 12578718_12579412- (hsa_circ_0010023; host gene DHRS3) is up-regulated in papillary thyroid carcinoma and has diagnostic potential supported by RT-qPCR validation and ROC analyses in two clinical cohorts. Its downstream mechanism is not experimentally validated and was only explored via predicted ceRNA network analysis.	0.5047
34188490	OncoTargets and therapy	2021	Expression Profiles of Circular RNAs in Human Papillary Thyroid Carcinoma Based on RNA Deep Sequencing.	hsa_circ_0002699	chr7: 116695750_116700284+	hsa_circ_MET	MET	Papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; RNA-seq	chr7: 116695750_116700284+ (hsa_circ_0002699; host gene MET) is up-regulated in papillary thyroid carcinoma and shows diagnostic potential based on RT-qPCR and ROC analyses. Mechanistic effects were not experimentally tested and were only assessed through predicted ceRNA network construction.	0.5047
34188490	OncoTargets and therapy	2021	Expression Profiles of Circular RNAs in Human Papillary Thyroid Carcinoma Based on RNA Deep Sequencing.	hsa_circ_0082002	chr7: 116699071_116700284+	hsa_circ_MET	MET	Papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; RNA-seq	"chr7: 116699071_116700284+ (hsa_circ_0082002; host gene MET) is up-regulated in papillary thyroid carcinoma and performs well as a diagnostic marker in ROC analyses after RT-qPCR validation. It was additionally used for stability testing in TPC1 cells, showing higher tolerance to RNase R, temperature, and time compared with linear mRNA; mechanistic ceRNA interactions were only computationally predicted."	0.7113
34188490	OncoTargets and therapy	2021	Expression Profiles of Circular RNAs in Human Papillary Thyroid Carcinoma Based on RNA Deep Sequencing.	hsa_circ_0129039	chr5: 38481299_38530666-	hsa_circ_LIFR	LIFR	Papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR; RNA-seq	chr5: 38481299_38530666- (hsa_circ_0129039; host gene LIFR) is markedly down-regulated in papillary thyroid carcinoma and was among the RT-qPCR-verified circRNAs evaluated for diagnostic potential using ROC curves.	0.4679
34188490	OncoTargets and therapy	2021	Expression Profiles of Circular RNAs in Human Papillary Thyroid Carcinoma Based on RNA Deep Sequencing.	hsa_circ_0093332	chr10: 179994_249088+	hsa_circ_ZMYND11	ZMYND11	Papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR; RNA-seq	chr10: 179994_249088+ (hsa_circ_0093332; host gene ZMYND11) is down-regulated in papillary thyroid carcinoma and has diagnostic value supported by RT-qPCR and ROC analyses. It was also included as a component of a multivariate logistic-regression Combined Prediction Index for PTC diagnosis; mechanistic roles were only predicted via bioinformatics ceRNA analysis.	0.5047
34188490	OncoTargets and therapy	2021	Expression Profiles of Circular RNAs in Human Papillary Thyroid Carcinoma Based on RNA Deep Sequencing.	hsa_circ_0121603	chr3: 121378716_121381532+	hsa_circ_STXBP5L	STXBP5L	Papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR; RNA-seq	chr3: 121378716_121381532+ (hsa_circ_0121603; host gene STXBP5L) is down-regulated in papillary thyroid carcinoma and was RT-qPCR-validated in clinical samples; diagnostic capability was assessed via ROC analysis among the verified circRNAs.	0.4679
34188490	OncoTargets and therapy	2021	Expression Profiles of Circular RNAs in Human Papillary Thyroid Carcinoma Based on RNA Deep Sequencing.	hsa_circ_0112640	chr1: 237423092_237445522+	hsa_circ_RYR2	RYR2	Papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR; RNA-seq	chr1: 237423092_237445522+ (hsa_circ_0112640; host gene RYR2) is down-regulated in papillary thyroid carcinoma and was among the RT-qPCR-validated circRNAs whose diagnostic potential was evaluated by ROC analysis.	0.4679
34188490	OncoTargets and therapy	2021	Expression Profiles of Circular RNAs in Human Papillary Thyroid Carcinoma Based on RNA Deep Sequencing.		chr2: 159932176_159945082-	hsa_circ_PLA2R1	PLA2R1	Papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR; RNA-seq	chr2: 159932176_159945082- (host gene PLA2R1) is down-regulated in papillary thyroid carcinoma and was included among the RT-qPCR-validated circRNAs whose diagnostic potential was evaluated using ROC curves; no specific mechanism was experimentally validated.	0.4679
34188491	OncoTargets and therapy	2021	Identification of Enzalutamide Resistance-Related circRNA-miRNA-mRNA Regulatory Networks in Patients with Prostate Cancer.	hsa_circ_0047641		hsa_circ_DYM	DYM	prostate cancer 	MONDO:0008315	prostate cancer	dysregulated	RT-qPCR; Microarray	"In this study, hsa_circ_0047641 was implicated in prostate cancer progression and enzalutamide resistance. It is mainly cytoplasmic and was analyzed as part of a proposed ceRNA subnetwork (hsa_circ_0047641/hsa_miR338-5p/RRM2). Silencing hsa_circ_0047641 reduced proliferation, migration/invasion, and enzalutamide-resistant cell growth in vitro."	0.508
34193158	Journal of nanobiotechnology	2021	Mesenchymal stem cell-derived extracellular vesicles prevent the development of osteoarthritis via the circHIPK3/miR-124-3p/MYH9 axis.		circHIPK3 	mmu_circ_HIPK3	HIPK3	osteoarthritis 	MONDO:0005178	osteoarthritis	unknown	RT-qPCR	"In a mouse osteoarthritis model, MSC-derived extracellular vesicles deliver circHIPK3 to chondrocytes, where circHIPK3 mainly localizes in the cytoplasm and functions as a ceRNA. By sponging miR-124-3p, circHIPK3 increases MYH9 expression, promoting chondrocyte proliferation/migration and inhibiting apoptosis, thereby alleviating IL-1beta-induced injury and supporting cartilage repair."	0.7375
34197029	Journal of cellular and molecular medicine	2021	Silencing of circTASP1 inhibits proliferation and induces apoptosis of acute myeloid leukaemia cells through modulating miR-515-5p/HMGA2 axis.	hsa_circ_0007340	circTASP1 	hsa_circ_TASP1	TASP1	acute myeloid leukaemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; Microarray	"circTASP1 (hsa_circ_0007340, from TASP1) is up-regulated in AML peripheral blood and AML cell lines. It mainly localizes to the cytoplasm and promotes AML cell proliferation while inhibiting apoptosis by sponging miR-515-5p, thereby increasing HMGA2; circTASP1 knockdown suppresses xenograft tumour growth and high circTASP1 expression predicts poor survival."	0.8823
34198263	Aging	2021	Plasma cell-free circRNAs panel act as fingerprint predicts the occurrence of laryngeal squamous cell carcinoma.	hsa_circ_0019201	circ_0019201			laryngeal squamous cell carcinoma 	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	circ_0019201 is up-regulated in plasma from LSCC patients versus controls (microarray and RT-qPCR). It shows diagnostic value by ROC analysis and contributes to a multi-circRNA plasma panel for LSCC prediction.	0.5202
34198263	Aging	2021	Plasma cell-free circRNAs panel act as fingerprint predicts the occurrence of laryngeal squamous cell carcinoma.	hsa_circ_0011773	circ_0011773			laryngeal squamous cell carcinoma 	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	circ_0011773 is up-regulated in plasma from LSCC patients versus controls (microarray and RT-qPCR). It has diagnostic performance by ROC analysis and is part of a 3-circRNA plasma panel to predict LSCC.	0.5202
34198263	Aging	2021	Plasma cell-free circRNAs panel act as fingerprint predicts the occurrence of laryngeal squamous cell carcinoma.	hsa_circ_0122790	circ_0122790			laryngeal squamous cell carcinoma 	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	circ_0122790 is up-regulated in plasma from LSCC patients versus controls (microarray and RT-qPCR). It shows high diagnostic accuracy in ROC analysis and is part of a combined 3-circRNA panel for LSCC prediction.	0.5202
34198978	"Pharmaceuticals (Basel, Switzerland)"	2021	Serum Extracellular Vesicle-Derived circHIPK3 and circSMARCA5 Are Two Novel Diagnostic Biomarkers for Glioblastoma Multiforme.	hsa_circ_0001445	circSMARCA5	hsa_circ_SMARCA5	SMARCA5	Glioblastoma multiforme 	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR	"Serum small extracellular vesicle-derived circSMARCA5 is decreased in GBM patients compared with unaffected controls (and also lower vs grade 3 glioma), and its ddPCR level provides diagnostic discrimination for GBM by ROC analysis."	0.5047
34198978	"Pharmaceuticals (Basel, Switzerland)"	2021	Serum Extracellular Vesicle-Derived circHIPK3 and circSMARCA5 Are Two Novel Diagnostic Biomarkers for Glioblastoma Multiforme.	hsa_circ_0000284	circHIPK3	hsa_circ_HIPK3	HIPK3	Glioblastoma multiforme 	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR	"Serum small extracellular vesicle-derived circHIPK3 is decreased in GBM patients compared with unaffected controls (and also lower vs grade 3 glioma), and its ddPCR level shows diagnostic utility for GBM by ROC analysis."	0.5047
34199580	Cancers	2021	Clinicopathological-Associated Regulatory Network of Deregulated circRNAs in Hepatocellular Carcinoma.		circGPC3 	hsa_circ_GPC3	GPC3	Hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"circGPC3 is up-regulated in HCC tumors and is linked to higher tumor grade. It promotes proliferation, cell-cycle progression, transformation, migration and invasion, and functions as a ceRNA by sponging miR-378a-3p (and predicted miR-378c) to upregulate ASPM, supported by luciferase, Ago2-RIP and pull-down assays."	0.8778
34199580	Cancers	2021	Clinicopathological-Associated Regulatory Network of Deregulated circRNAs in Hepatocellular Carcinoma.		circW7 	hsa_circ_WHSC1	WHSC1	Hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"circW7 is up-regulated in HCC and associated with aggressive clinicopathological features. Overexpression promotes proliferation and anchorage-independent growth in liver cell lines, and it can interact with Ago2, suggesting miRNA-related regulation."	0.835
34199580	Cancers	2021	Clinicopathological-Associated Regulatory Network of Deregulated circRNAs in Hepatocellular Carcinoma.		circW8 	hsa_circ_WHSC1	WHSC1	Hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"circW8 is up-regulated in HCC and associated with aggressive clinicopathological features. Its knockdown reduces proliferation and anchorage-independent growth in Huh7 cells, and it interacts with Ago2, consistent with miRNA-related regulatory potential."	0.835
34199580	Cancers	2021	Clinicopathological-Associated Regulatory Network of Deregulated circRNAs in Hepatocellular Carcinoma.		circW3 	hsa_circ_WHSC1	WHSC1	Hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"circW3 is up-regulated in HCC and associated with aggressive clinicopathological features. Its overexpression promotes proliferation and anchorage-independent growth, and it interacts with Ago2, consistent with a potential miRNA-associated mechanism."	0.835
34199580	Cancers	2021	Clinicopathological-Associated Regulatory Network of Deregulated circRNAs in Hepatocellular Carcinoma.		circRaly 	hsa_circ_RALY		Hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"circRaly is up-regulated in HCC, linked to higher tumor grade, and high expression is associated with poorer overall survival. Functionally, its overexpression promotes anchorage-independent growth and shows a non-significant trend toward increased proliferation; it interacts with Ago2 suggesting miRNA-related regulation."	0.8513
34203273	Genes	2021	CircVAMP3: A circRNA with a Role in Alveolar Rhabdomyosarcoma Cell Cycle Progression.	hsa_circ_0006354	circVAMP3	hsa_circ_VAMP3	VAMP3	alveolar rhabdomyosarcoma 	MONDO:0009994	alveolar rhabdomyosarcoma	up-regulated	RT-qPCR; RNA-seq	"circVAMP3 (hsa_circ_0006354) is up-regulated in the ARMS cell line RH4 and is mainly cytoplasmic. siRNA knockdown of circVAMP3 alters AKT/ERK-related signaling and cell-cycle regulators (e.g., WEE1, CDKN1A), leading to impaired cell-cycle progression with G2 accumulation, supporting circVAMP3 as a potential therapeutic target in alveolar rhabdomyosarcoma."	0.6862
34207029	"Molecules (Basel, Switzerland)"	2021	"Micro-Raman Characterization of Structural Features of High-k Stack Layer of SOI Nanowire Chip, Designed to Detect Circular RNA Associated with the Development of Glioma."		circ-SHKBP1	hsa_circ_SHKBP1	SHKBP1	glioma	MONDO:0021042	glioma	unknown	Microarray	"This study used a high-k SOI nanowire chip to detect circ-SHKBP1 (via complementary DNA probes) in human blood plasma samples from patients with brain/CNS neoplasms of uncertain nature, demonstrating feasibility for highly sensitive liquid-biopsy-style detection. The work focuses on biosensor detection capability rather than circ-SHKBP1¡¯s biological mechanism or expression direction in glioma."	0.2995
34216509	Journal of clinical laboratory analysis	2021	"Circular RNA_0001946 is insufficiently expressed in tumor tissues, while its higher expression correlates with less lymph node metastasis, lower TNM stage, and improved prognosis in NSCLC patients."	hsa_circ_0001946				non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"In this retrospective NSCLC cohort, circ_0001946 is down-regulated in tumor tissues compared with adjacent tissues. Higher tumor circ_0001946 expression is associated with less lymph node metastasis, lower TNM stage, and better DFS/OS, and remains an independent favorable prognostic factor."	0.5727
34219377	Pharmacology research & perspectives	2021	"Circ_0001821 knockdown suppresses growth, metastasis, and TAX resistance of non-small-cell lung cancer cells by regulating the miR-526b-5p/GRK5 axis."	hsa_circ_0001821	circ_0001821 	hsa_circ_PVT1	PVT1	non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0001821 is up-regulated in NSCLC tissues and cell lines and functions as an oncogenic circRNA. Its knockdown suppresses proliferation/colony formation, migration/invasion, and in vivo tumor growth while increasing paclitaxel sensitivity and apoptosis, mainly by sponging miR-526b-5p to relieve repression of GRK5 (circ_0001821/miR-526b-5p/GRK5 axis). High circ_0001821 expression is associated with poorer overall survival in NSCLC patients."	0.737
34220494	Frontiers in pharmacology	2021	Berberine Sensitizes Human Hepatoma Cells to Regorafenib via Modulating Expression of Circular RNAs.	hsa_circ_0032029				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"In HCC cells treated with berberine plus regorafenib, hsa_circ_0032029 is up-regulated and is proposed by the authors as a candidate circRNA that may contribute to the synergistic anti-tumor effect of the combination therapy. No specific downstream miRNA/target axis or pathway was experimentally established in this study."	0.5089
34220494	Frontiers in pharmacology	2021	Berberine Sensitizes Human Hepatoma Cells to Regorafenib via Modulating Expression of Circular RNAs.	hsa_circ_0008928				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"In HCC cells treated with berberine plus regorafenib, hsa_circ_0008928 is up-regulated and highlighted as a candidate circRNA potentially linked to the synergistic anti-tumor activity of the drug combination. The study did not experimentally define its direct targets or a specific regulatory axis."	0.5089
34221006	Gastroenterology research and practice	2021	Circular RNA CDR1as Inhibits the Metastasis of Gastric Cancer through Targeting miR-876-5p/GNG7 Axis.		CDR1as 	hsa_circ_CDR1	CDR1	gastric cancer 	MONDO:0001056	gastric cancer	unknown	RT-qPCR	"In gastric cancer models, CDR1as suppresses migration, invasion and in vivo metastasis. Mechanistically, it functions as a ceRNA by sponging miR-876-5p to de-repress/upregulate GNG7, leading to inhibition of EMT-associated changes and reduced MMP2/MMP9."	0.5554
34221216	The World Allergy Organization journal	2021	CircRNA expression profiles and circRNA-miRNA-mRNA crosstalk in allergic rhinitis.	hsa_circ_0008668				allergic rhinitis 	MONDO:0011786	allergic rhinitis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0008668 is significantly up-regulated in nasal mucosa tissues from patients with allergic rhinitis compared with controls, as supported by HTS and RT-PCR with back-splice junction confirmed by Sanger sequencing."	0.5541
34221216	The World Allergy Organization journal	2021	CircRNA expression profiles and circRNA-miRNA-mRNA crosstalk in allergic rhinitis.	hsa_circ_0029853		hsa_circ_PAN3	PAN3	allergic rhinitis 	MONDO:0011786	allergic rhinitis	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0029853 is down-regulated in allergic rhinitis nasal mucosa and is predicted (via the constructed ceRNA network) to sponge hsa-miR-98-5p/hsa-miR-140-5p/hsa-miR-3065-5p, thereby regulating ERRFI1 and NRCAM, potentially affecting EGFR-related signaling and promoting AR progression."	0.585
34221216	The World Allergy Organization journal	2021	CircRNA expression profiles and circRNA-miRNA-mRNA crosstalk in allergic rhinitis.		circTRIQK	hsa_circ_TRIQK	TRIQK	allergic rhinitis 	MONDO:0011786	allergic rhinitis	up-regulated	RT-qPCR; RNA-seq	"circTRIQK is significantly up-regulated in allergic rhinitis nasal mucosa, supported by HTS and RT-PCR, and its back-splice junction was validated by Sanger sequencing."	0.5541
34221216	The World Allergy Organization journal	2021	CircRNA expression profiles and circRNA-miRNA-mRNA crosstalk in allergic rhinitis.		circRNA_01002			allergic rhinitis 	MONDO:0011786	allergic rhinitis	down-regulated	RT-qPCR; RNA-seq	"circRNA_01002 is significantly down-regulated in allergic rhinitis nasal mucosa, supported by HTS and RT-PCR, and its back-splice junction was validated by Sanger sequencing."	0.5541
34221216	The World Allergy Organization journal	2021	CircRNA expression profiles and circRNA-miRNA-mRNA crosstalk in allergic rhinitis.		circCDKAL1	hsa_circ_CDKAL1	CDKAL1	allergic rhinitis 	MONDO:0011786	allergic rhinitis	up-regulated	RNA-seq	circCDKAL1 is one of the differentially expressed circRNAs included in the constructed AR-associated circRNA-miRNA-mRNA crosstalk network and is up-regulated in AR based on HTS results.	0.1768
34221216	The World Allergy Organization journal	2021	CircRNA expression profiles and circRNA-miRNA-mRNA crosstalk in allergic rhinitis.		circPCMT1	hsa_circ_PCMT1	PCMT1	allergic rhinitis 	MONDO:0011786	allergic rhinitis	up-regulated	RNA-seq	circPCMT1 is an up-regulated circRNA in AR identified by HTS and included in the study¡¯s constructed circRNA-miRNA-mRNA crosstalk network.	0.1768
34221216	The World Allergy Organization journal	2021	CircRNA expression profiles and circRNA-miRNA-mRNA crosstalk in allergic rhinitis.		circARHGEF33	hsa_circ_ARHGEF33	ARHGEF33	allergic rhinitis 	MONDO:0011786	allergic rhinitis	down-regulated	RNA-seq	circARHGEF33 is a down-regulated circRNA in AR identified by HTS and included in the study¡¯s constructed circRNA-miRNA-mRNA crosstalk network.	0.1768
34221216	The World Allergy Organization journal	2021	CircRNA expression profiles and circRNA-miRNA-mRNA crosstalk in allergic rhinitis.		circNCOA1	hsa_circ_NCOA1	NCOA1	allergic rhinitis 	MONDO:0011786	allergic rhinitis	up-regulated	RNA-seq	circNCOA1 is an up-regulated circRNA in AR identified by HTS and included in the study¡¯s constructed circRNA-miRNA-mRNA crosstalk network.	0.1768
34221216	The World Allergy Organization journal	2021	CircRNA expression profiles and circRNA-miRNA-mRNA crosstalk in allergic rhinitis.		circRNA_15993			allergic rhinitis 	MONDO:0011786	allergic rhinitis	up-regulated	RNA-seq	circRNA_15993 is an up-regulated intergenic circRNA in AR identified by HTS and included in the constructed circRNA-miRNA-mRNA crosstalk network.	0.1768
34221216	The World Allergy Organization journal	2021	CircRNA expression profiles and circRNA-miRNA-mRNA crosstalk in allergic rhinitis.		circRNA_07795			allergic rhinitis 	MONDO:0011786	allergic rhinitis	down-regulated	RNA-seq	circRNA_07795 is a down-regulated intergenic circRNA in AR identified by HTS and included in the constructed circRNA-miRNA-mRNA crosstalk network.	0.1768
34221216	The World Allergy Organization journal	2021	CircRNA expression profiles and circRNA-miRNA-mRNA crosstalk in allergic rhinitis.		circRNA_07800			allergic rhinitis 	MONDO:0011786	allergic rhinitis	down-regulated	RNA-seq	circRNA_07800 is a down-regulated intergenic circRNA in AR identified by HTS and included in the constructed circRNA-miRNA-mRNA crosstalk network.	0.1768
34222420	World journal of clinical cases	2021	Identification of the circRNA-miRNA-mRNA regulatory network and its prognostic effect in colorectal cancer.	hsa_circ_0000520				colorectal cancer 	MONDO:0005575	colorectal cancer	dysregulated	Microarray	hsa_circ_0000520 was identified as a differentially expressed circRNA in colorectal cancer and included in a predicted circRNA_miRNA_mRNA ceRNA network based on GEO datasets and target prediction databases; no experimental functional validation was performed.	0.1768
34222420	World journal of clinical cases	2021	Identification of the circRNA-miRNA-mRNA regulatory network and its prognostic effect in colorectal cancer.	hsa_circ_0000519				colorectal cancer 	MONDO:0005575	colorectal cancer	dysregulated	Microarray	hsa_circ_0000519 was identified as a differentially expressed circRNA in colorectal cancer and incorporated into a predicted ceRNA network constructed from GEO microarray datasets and target predictions; it was not experimentally validated in this study.	0.1768
34222420	World journal of clinical cases	2021	Identification of the circRNA-miRNA-mRNA regulatory network and its prognostic effect in colorectal cancer.	hsa_circ_0001955				colorectal cancer 	MONDO:0005575	colorectal cancer	dysregulated	Microarray	hsa_circ_0001955 was detected as differentially expressed in colorectal cancer and used as a node in a computationally inferred circRNA_miRNA_mRNA ceRNA network; the study did not experimentally validate its expression or function.	0.1768
34222420	World journal of clinical cases	2021	Identification of the circRNA-miRNA-mRNA regulatory network and its prognostic effect in colorectal cancer.	hsa_circ_0028198				colorectal cancer 	MONDO:0005575	colorectal cancer	dysregulated	Microarray	hsa_circ_0028198 was computationally identified as a CRC-associated differentially expressed circRNA and included in a predicted circRNA_miRNA_mRNA network; no wet-lab validation was provided.	0.1768
34222420	World journal of clinical cases	2021	Identification of the circRNA-miRNA-mRNA regulatory network and its prognostic effect in colorectal cancer.	hsa_circ_0080210				colorectal cancer 	MONDO:0005575	colorectal cancer	dysregulated	Microarray	hsa_circ_0080210 is a CRC-associated differentially expressed circRNA included in a prognostic ceRNA subnetwork (with miRNAs including miR-671-5p/miR-765 and mRNAs including ITLN1/LRRC19) inferred from GEO/TCGA analyses; its biological roles were not experimentally validated.	0.1768
34222420	World journal of clinical cases	2021	Identification of the circRNA-miRNA-mRNA regulatory network and its prognostic effect in colorectal cancer.	hsa_circ_0007158				colorectal cancer 	MONDO:0005575	colorectal cancer	dysregulated	Microarray	hsa_circ_0007158 is part of a prognostic CRC ceRNA subnetwork inferred by database-driven target prediction and differential expression analysis; its specific function and direction of effect were not experimentally determined.	0.1768
34222420	World journal of clinical cases	2021	Identification of the circRNA-miRNA-mRNA regulatory network and its prognostic effect in colorectal cancer.	hsa_circ_0000375				colorectal cancer 	MONDO:0005575	colorectal cancer	dysregulated	Microarray	hsa_circ_0000375 is a predicted CRC-related circRNA included in a prognostic ceRNA subnetwork (with miR-671-5p/miR-765 and ITLN1/LRRC19) but lacks experimental validation in this paper.	0.1768
34222420	World journal of clinical cases	2021	Identification of the circRNA-miRNA-mRNA regulatory network and its prognostic effect in colorectal cancer.	hsa_circ_0000026				colorectal cancer 	MONDO:0005575	colorectal cancer	dysregulated	Microarray	hsa_circ_0000026 was identified as a differentially expressed circRNA in CRC and included in a predicted ceRNA network; no direct experimental verification was performed.	0.1768
34222420	World journal of clinical cases	2021	Identification of the circRNA-miRNA-mRNA regulatory network and its prognostic effect in colorectal cancer.	hsa_circ_0023685				colorectal cancer 	MONDO:0005575	colorectal cancer	dysregulated	Microarray	hsa_circ_0023685 was computationally identified as a CRC-associated differentially expressed circRNA within a predicted ceRNA network; no direct experimental validation or specific miRNA partners were provided for this circRNA.	0.1768
34222420	World journal of clinical cases	2021	Identification of the circRNA-miRNA-mRNA regulatory network and its prognostic effect in colorectal cancer.	hsa_circ_0000370				colorectal cancer 	MONDO:0005575	colorectal cancer	dysregulated	Microarray	hsa_circ_0000370 was computationally identified as a differentially expressed circRNA in CRC and included in the inferred ceRNA network; no direct experimental confirmation was included.	0.1768
34222420	World journal of clinical cases	2021	Identification of the circRNA-miRNA-mRNA regulatory network and its prognostic effect in colorectal cancer.	hsa_circ_0061817				colorectal cancer 	MONDO:0005575	colorectal cancer	dysregulated	Microarray	hsa_circ_0061817 was identified from GEO microarray data as a CRC-associated differentially expressed circRNA and included as a node in the predicted ceRNA network; no experimental validation was done.	0.1768
34222420	World journal of clinical cases	2021	Identification of the circRNA-miRNA-mRNA regulatory network and its prognostic effect in colorectal cancer.	hsa_circ_0005927				colorectal cancer 	MONDO:0005575	colorectal cancer	dysregulated	Microarray	hsa_circ_0005927 was identified as a differentially expressed circRNA in CRC and included in the constructed ceRNA network via bioinformatics analysis only.	0.1768
34222420	World journal of clinical cases	2021	Identification of the circRNA-miRNA-mRNA regulatory network and its prognostic effect in colorectal cancer.	hsa_circ_0072088				colorectal cancer 	MONDO:0005575	colorectal cancer	dysregulated	Microarray	hsa_circ_0072088 was identified as a CRC-related differentially expressed circRNA and included in the predicted ceRNA network; no functional experiments were conducted in this paper.	0.1768
34222420	World journal of clinical cases	2021	Identification of the circRNA-miRNA-mRNA regulatory network and its prognostic effect in colorectal cancer.	hsa_circ_0018909				colorectal cancer 	MONDO:0005575	colorectal cancer	dysregulated	Microarray	"hsa_circ_0018909 was included in a CRC prognostic ceRNA subnetwork inferred from GEO/TCGA data; it is proposed as a potential biomarker, but its function/mechanism were not experimentally validated."	0.1768
34222420	World journal of clinical cases	2021	Identification of the circRNA-miRNA-mRNA regulatory network and its prognostic effect in colorectal cancer.	hsa_circ_0013912				colorectal cancer 	MONDO:0005575	colorectal cancer	dysregulated	Microarray	hsa_circ_0013912 was identified as a CRC-associated differentially expressed circRNA and included in the inferred ceRNA network; no experimental verification or specific regulatory axis was confirmed in this paper.	0.1768
34222420	World journal of clinical cases	2021	Identification of the circRNA-miRNA-mRNA regulatory network and its prognostic effect in colorectal cancer.	hsa_circ_0071681				colorectal cancer 	MONDO:0005575	colorectal cancer	dysregulated	Microarray	"hsa_circ_0071681 was identified by GEO microarray differential expression and included in the constructed CRC ceRNA network, without experimental validation."	0.1768
34222420	World journal of clinical cases	2021	Identification of the circRNA-miRNA-mRNA regulatory network and its prognostic effect in colorectal cancer.	hsa_circ_0011536				colorectal cancer 	MONDO:0005575	colorectal cancer	dysregulated	Microarray	hsa_circ_0011536 is a CRC-associated differentially expressed circRNA and part of a proposed prognostic ceRNA axis hsa_circ_0011536_hsa-miR-601_CA2 inferred from expression datasets and target prediction; experimental validation was not performed in this study.	0.1768
34222420	World journal of clinical cases	2021	Identification of the circRNA-miRNA-mRNA regulatory network and its prognostic effect in colorectal cancer.	hsa_circ_0043278				colorectal cancer 	MONDO:0005575	colorectal cancer	dysregulated	Microarray	hsa_circ_0043278 was included among the CRC differentially expressed circRNAs and incorporated into the predicted ceRNA network; no experimental validation or specific partners were reported.	0.1768
34222420	World journal of clinical cases	2021	Identification of the circRNA-miRNA-mRNA regulatory network and its prognostic effect in colorectal cancer.	hsa_circ_0006220				colorectal cancer 	MONDO:0005575	colorectal cancer	dysregulated	Microarray	hsa_circ_0006220 was computationally identified as a differentially expressed circRNA in CRC and included in the inferred ceRNA network; no experimental validation was conducted.	0.1768
34224315	Bioengineered	2021	CircRAB3IP upregulates twist family BHLH transcription factor (TWIST1) to promote osteosarcoma progression by sponging miR-580-3p.	hsa_circ_0000419	circRAB3IP 	hsa_circ_RAB3IP	RAB3IP	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circRAB3IP is up-regulated in osteosarcoma tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation, migration, invasion and in vivo tumor growth by sponging miR-580-3p, thereby relieving repression of TWIST1 (circRAB3IP/miR-580-3p/TWIST1 ceRNA axis)."	0.7695
34226522	Cell death & disease	2021	Circular RNA hsa_circ_0000277 sequesters miR-4766-5p to upregulate LAMA1 and promote esophageal carcinoma progression.	hsa_circ_0000277	circPDE3B	hsa_circ_PDE3B	PDE3B	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circPDE3B (hsa_circ_0000277) is up-regulated in ESCC and promotes proliferation and metastasis. It functions as a ceRNA by sponging miR-4766-5p to upregulate LAMA1, thereby activating EMT, and high circPDE3B predicts poor survival."	0.8837
34226531	Cell death discovery	2021	Circ_0030998 promotes tumor proliferation and angiogenesis by sponging miR-567 to regulate VEGFA in colorectal cancer.	hsa_circ_0030998	Circ_0030998	hsa_circ_LAMP1	LAMP1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"Circ_0030998 is up-regulated in colorectal cancer tissues and cell lines and promotes CRC proliferation, cell-cycle progression, and HUVEC angiogenesis. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-567, thereby relieving miR-567-mediated repression of VEGFA. High Circ_0030998 expression is associated with shorter survival and serves as an independent prognostic factor in CRC."	0.7859
34229638	BMC cancer	2021	A circular RNAs dataset landscape reveals potential signatures for the detection and prognosis of early-stage lung adenocarcinoma.	hsa_circ_0062682				early-stage lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0062682 is up-regulated in early-stage lung adenocarcinoma tissues and is highlighted as a potential diagnostic circRNA. Bioinformatic prediction places it in a circRNA_miRNA_mRNA ceRNA network where it interacts with hsa-miR-4268, with downstream genes enriched in Wnt signaling."	0.4032
34229638	BMC cancer	2021	A circular RNAs dataset landscape reveals potential signatures for the detection and prognosis of early-stage lung adenocarcinoma.	hsa_circ_0070610				early-stage lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0070610 is up-regulated in early-stage lung adenocarcinoma tissues and included in a predicted circRNA_miRNA_mRNA ceRNA network. It is predicted to bind hsa-let-7a-2-3p and hsa-miR-3622a-3p, linking it to downstream prognosis-related genes enriched in Wnt signaling."	0.4032
34234548	Cancer management and research	2021	CircCSNK1G1 Contributes to the Tumorigenesis of Gastric Cancer by Sponging miR-758 and Regulating ZNF217 Expression.		circCSNK1G1	hsa_circ_CSNK1G1	CSNK1G1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circCSNK1G1 is up-regulated in gastric cancer tissues, cells, and patient serum, and its high expression is associated with poorer overall survival and diagnostic potential. Functionally, circCSNK1G1 promotes GC cell proliferation, migration and invasion and inhibits apoptosis, and supports xenograft tumor growth. Mechanistically, it sponges miR-758 to upregulate ZNF217, forming a circCSNK1G1/miR-758/ZNF217 ceRNA axis."	0.7731
34234552	Cancer management and research	2021	CircASXL1 Knockdown Restrains Hypoxia-Induced DDP Resistance and NSCLC Progression by Sponging miR-206.		circASXL1 	hsa_circ_ASXL1	ASXL1	Non-small cell lung carcinoma 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circASXL1 is up-regulated in NSCLC tissues/cells and further increased under hypoxia. It promotes hypoxia-induced cisplatin (DDP) resistance and malignant phenotypes by sponging miR-206 and thereby sustaining HIF-1alpha expression; circASXL1 knockdown restores DDP sensitivity, suppresses proliferation/migration/invasion, and increases apoptosis, including reduced tumor growth in vivo."	0.783
34234564	Cancer management and research	2021	Hsa_circRNA_000543 Predicts Poor Prognosis and Promotes Cervical Cancer Cell Progression Through Regulating miR-567/ZNF268 Axis.	hsa_circ_0000326	hsa_circRNA_000543 	hsa_circ_MALAT1	MALAT1	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"In cervical cancer, hsa_circ_000543 is up-regulated and acts as an oncogenic circRNA. It sponges miR-567 to increase ZNF268 expression, thereby promoting proliferation/colony formation/migration/invasion and inhibiting apoptosis; high expression is associated with poorer overall survival."	0.7657
34234808	Frontiers in genetics	2021	CircCA12 Promotes Malignant Process via Sponging miR-1184 and Upregulating RAS Family in Bladder Cancer.		circCA12	hsa_circ_CA12	CA12	urinary bladder cancer 	MONDO:0001187	urinary bladder cancer	up-regulated	RT-qPCR	"circCA12 is up-regulated in bladder cancer tissues and cell lines and promotes malignant phenotypes including proliferation, invasion/migration, and metastasis. Mechanistically, circCA12 mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-1184, leading to upregulation of RAS family targets (KRAS/NRAS/HRAS) and promoting UBC progression."	0.7979
34234811	Frontiers in genetics	2021	circARL15 Plays a Critical Role in Intervertebral Disc Degeneration by Modulating miR-431-5p/DISC1.	hsa_circ_0072464	circARL15	hsa_circ_ARL15	ARL15	Intervertebral disk degeneration 	MONDO:0011385	intervertebral disk degenerative disorder	down-regulated	RT-qPCR; Microarray	"circARL15 is down-regulated in intervertebral disc degeneration and functions as a ceRNA by sponging miR-431-5p to increase DISC1. Functionally, circARL15 promotes NP cell proliferation and inhibits apoptosis, and its intradiscal overexpression alleviates IDD in a rat puncture model."	0.7302
34234862	Journal of Cancer	2021	circALPL Sponges miR-127 to Promote Gastric Cancer Progression by Enhancing MTDH Expression.		circALPL 	hsa_circ_ALPL	ALPL	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circALPL (hsa-circ-0010519), derived from ALPL, is up-regulated in gastric cancer tissues and cell lines and promotes proliferation and invasion/metastasis while suppressing apoptosis. Mechanistically, it mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-127-5p to increase MTDH expression, forming a circALPL/miR-127-5p/MTDH axis."	0.7897
34235193	Frontiers in veterinary science	2021	Genome-Wide Differential Expression Profiling of Pulmonary circRNAs Associated With Immune Reaction to Pasteurella multocida in Goats.		chicirc_000298			Pasteurella multocida infection 	MONDO:0040998	Pasteurella multocida infectious disease	down-regulated	RNA-seq	chicirc_000298 is down-regulated in goat lung after P. multocida challenge and was included in an immune-related ceRNA network. It may contribute to infection-associated inflammatory/immune responses via circRNA_miRNA_mRNA regulation.	0.1768
34235193	Frontiers in veterinary science	2021	Genome-Wide Differential Expression Profiling of Pulmonary circRNAs Associated With Immune Reaction to Pasteurella multocida in Goats.		chicirc_020284			Pasteurella multocida infection 	MONDO:0040998	Pasteurella multocida infectious disease	down-regulated	RNA-seq	chicirc_020284 is down-regulated in P. multocida-infected goat lung and was included in the downregulated circRNA ceRNA network. It is implicated in immune/inflammatory responses via circRNA_miRNA_mRNA regulation.	0.1768
34235193	Frontiers in veterinary science	2021	Genome-Wide Differential Expression Profiling of Pulmonary circRNAs Associated With Immune Reaction to Pasteurella multocida in Goats.		chicirc_028852			Pasteurella multocida infection 	MONDO:0040998	Pasteurella multocida infectious disease	down-regulated	RNA-seq	"chicirc_028852 is down-regulated in infected goat lung and appears in the downregulated circRNA ceRNA network, suggesting a role in immune/inflammatory regulation during P. multocida infection."	0.1768
34235193	Frontiers in veterinary science	2021	Genome-Wide Differential Expression Profiling of Pulmonary circRNAs Associated With Immune Reaction to Pasteurella multocida in Goats.		chicirc_047509			Pasteurella multocida infection 	MONDO:0040998	Pasteurella multocida infectious disease	down-regulated	RNA-seq	"chicirc_047509 is down-regulated in P. multocida-infected goat lung and is part of an immune-related ceRNA network, implicating it in inflammatory/immune responses during infection."	0.1768
34235193	Frontiers in veterinary science	2021	Genome-Wide Differential Expression Profiling of Pulmonary circRNAs Associated With Immune Reaction to Pasteurella multocida in Goats.		chicirc_04689			Pasteurella multocida infection 	MONDO:0040998	Pasteurella multocida infectious disease	up-regulated	RNA-seq	"chicirc_04689 is up-regulated in lungs of goats infected with P. multocida and is predicted to sponge 13 downregulated miRNAs within a ceRNA framework. The study links this network to infection-associated inflammation/immune responses, though direct functional assays were not shown for this circRNA."	0.1768
34236145	Thoracic cancer	2021	Overexpression of hsa_circ_0008274 inhibited the progression of lung adenocarcinoma by regulating HMGA2 via sponging miR-578.	hsa_circ_0008274		hsa_circ_UGGT2	UGGT2	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR	"hsa_circ_0008274 is down-regulated in LUAD tissues and cell lines. Its overexpression suppresses LUAD cell proliferation, invasion and migration by sponging miR-578 and relieving miR-578-mediated regulation of HMGA2, forming a hsa_circ_0008274/miR-578/HMGA2 ceRNA axis."	0.779
34238972	Scientific reports	2021	Exosomal hsa_circRNA_104484 and hsa_circRNA_104670 may serve as potential novel biomarkers and therapeutic targets for sepsis.	hsa_circ_0082326	hsa_circRNA_104484	hsa_circ_ZC3HC1	ZC3HC1	sepsis	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_104484 is up-regulated in serum exosomes from sepsis patients and shows moderate diagnostic value by ROC analysis. Bioinformatic prediction suggests it may act as a miRNA sponge (e.g., miR-378a-3p/miR-378d) within a circRNA_miRNA_mRNA (ceRNA) network potentially linked to sepsis-related inflammatory signaling."	0.5963
34238972	Scientific reports	2021	Exosomal hsa_circRNA_104484 and hsa_circRNA_104670 may serve as potential novel biomarkers and therapeutic targets for sepsis.	hsa_circ_0001818	hsa_circRNA_104670	hsa_circ_UBR5	UBR5	sepsis	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_104670 is up-regulated in serum exosomes from sepsis patients and shows moderate diagnostic performance by ROC analysis. Bioinformatic prediction suggests it may function as a miRNA sponge (e.g., miR-17-3p) in a circRNA_miRNA_mRNA regulatory network relevant to sepsis-associated inflammatory pathways."	0.5963
34239561	Journal of oncology	2021	Circular RNA hsa_circ_0005046 and hsa_circ_0001791 May Become Diagnostic Biomarkers for Breast Cancer Early Detection.	hsa_circ_0005046		hsa_circ_ARL8B	ARL8B	Breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"hsa_circ_0005046 is up-regulated in breast cancer tissues and shows diagnostic potential by ROC analysis. Bioinformatics suggests it may act as a miRNA sponge (including miR-215) influencing PI3K/AKT signaling, potentially promoting malignant behaviors."	0.459
34239561	Journal of oncology	2021	Circular RNA hsa_circ_0005046 and hsa_circ_0001791 May Become Diagnostic Biomarkers for Breast Cancer Early Detection.	hsa_circ_0001791	hsa _circ_ 000179 	hsa_circ_ADAM9	ADAM9	Breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"hsa_circ_0001791 is up-regulated in breast cancer tissues and has strong diagnostic performance by ROC analysis (AUC reported). It is associated with ER status and is proposed (mainly by bioinformatics/discussion) to sponge miR-383 and affect PI3K/AKT signaling, potentially promoting malignant phenotypes."	0.459
34239873	Frontiers in cell and developmental biology	2021	CircUBAP2 Promotes MMP9-Mediated Oncogenic Effect via Sponging miR-194-3p in Hepatocellular Carcinoma.	hsa_circ_0003945	circUBAP2	hsa_circ_UBAP2	UBAP2	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circUBAP2 is up-regulated in hepatocellular carcinoma and promotes proliferation, migration/invasion, tumor growth and lung metastasis. It mainly functions as a cytoplasmic ceRNA by sponging miR-194-3p, thereby relieving repression of MMP9. High circUBAP2 is associated with worse OS/RFS and may serve as a prognostic biomarker and therapeutic target in HCC."	0.8892
34239876	Frontiers in cell and developmental biology	2021	Comprehensive Analysis of Peripheral Exosomal circRNAs in Large Artery Atherosclerotic Stroke.	hsa_circ_0000698				large artery atherosclerotic (LAA) stroke 	MONDO:0005490	large artery stroke	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0000698 is significantly down-regulated in plasma exosomes from LAA stroke patients and is part of a validated circRNA_miRNA_mRNA ceRNA network involving hsa-miR-16 and VWF. It also contributes to a multi-circRNA logistic model with diagnostic value for distinguishing LAA cases from controls.	0.5047
34239876	Frontiers in cell and developmental biology	2021	Comprehensive Analysis of Peripheral Exosomal circRNAs in Large Artery Atherosclerotic Stroke.	hsa_circ_0002775				large artery atherosclerotic (LAA) stroke 	MONDO:0005490	large artery stroke	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0002775 is significantly down-regulated in plasma exosomes from LAA stroke patients and participates in a circRNA_miRNA_mRNA ceRNA network involving hsa-miR-16 and VWF. It is also part of a four-circRNA diagnostic logistic model that discriminates LAA from controls.	0.5047
34239876	Frontiers in cell and developmental biology	2021	Comprehensive Analysis of Peripheral Exosomal circRNAs in Large Artery Atherosclerotic Stroke.	hsa_circ_0005585				large artery atherosclerotic (LAA) stroke 	MONDO:0005490	large artery stroke	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005585 is significantly down-regulated in plasma exosomes from LAA stroke patients. Its expression is confirmed by RT-qPCR and it shows diagnostic value (AUC 0.732), improving further when combined with other circRNAs in logistic models."	0.5047
34239876	Frontiers in cell and developmental biology	2021	Comprehensive Analysis of Peripheral Exosomal circRNAs in Large Artery Atherosclerotic Stroke.	hsa_circ_0043837				large artery atherosclerotic (LAA) stroke 	MONDO:0005490	large artery stroke	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0043837 is significantly down-regulated in plasma exosomes from LAA stroke patients and is validated by RT-qPCR as part of a ceRNA-network circRNA set. It contributes to a multi-circRNA logistic model with good diagnostic performance (AUC 0.862).	0.5047
34239876	Frontiers in cell and developmental biology	2021	Comprehensive Analysis of Peripheral Exosomal circRNAs in Large Artery Atherosclerotic Stroke.		novel_circ_0010155			large artery atherosclerotic (LAA) stroke 	MONDO:0005490	large artery stroke	down-regulated	RT-qPCR; RNA-seq	novel_circ_0010155 is down-regulated in plasma exosomes from LAA stroke patients and is linked to a validated ceRNA subnetwork with hsa-miR-939 and septin 9/MYLK2. It shows diagnostic potential with an AUC of 0.822.	0.5047
34243823	Human genomics	2021	High-throughput screening of circRNAs reveals novel mechanisms of tuberous sclerosis complex-related renal angiomyolipoma.		circRNA_025332			TSC-related renal angiomyolipoma 	MONDO:0004555	kidney angiomyolipoma	up-regulated	RT-qPCR; Microarray	"circRNA_025332 is up-regulated in TSC-RAML and is proposed to act as a miRNA sponge for miRNA873-5p, thereby increasing multiple target mRNAs (e.g., AMACR and LAMP2) associated with lipid metabolism. Its up-regulation is also positively correlated with fibroblast infiltration in the TSC-RAML microenvironment."	0.4032
34243823	Human genomics	2021	High-throughput screening of circRNAs reveals novel mechanisms of tuberous sclerosis complex-related renal angiomyolipoma.		circRNA_000799			TSC-related renal angiomyolipoma 	MONDO:0004555	kidney angiomyolipoma	up-regulated	RT-qPCR; Microarray	"circRNA_000799 is up-regulated in TSC-RAML and its expression is positively correlated with fibroblast infiltration in the TSC-RAML microenvironment. The paper includes it as an experimentally q-PCR-confirmed member of the ceRNA network, but does not specify its miRNA/mRNA partners in the provided text."	0.4032
34243823	Human genomics	2021	High-throughput screening of circRNAs reveals novel mechanisms of tuberous sclerosis complex-related renal angiomyolipoma.		circRNA_103608			TSC-related renal angiomyolipoma 	MONDO:0004555	kidney angiomyolipoma	down-regulated	RT-qPCR; Microarray	circRNA_103608 is down-regulated in TSC-RAML versus normal kidney tissue and was included in the study's ceRNA network as a differentially expressed circRNA with q-PCR validation; no specific downstream mechanism or partners are described in the provided text.	0.4032
34243823	Human genomics	2021	High-throughput screening of circRNAs reveals novel mechanisms of tuberous sclerosis complex-related renal angiomyolipoma.		circRNA_103982			TSC-related renal angiomyolipoma 	MONDO:0004555	kidney angiomyolipoma	down-regulated	RT-qPCR; Microarray	circRNA_103982 is down-regulated in TSC-RAML and was included in the ceRNA network as a q-PCR-validated differentially expressed circRNA; no specific mechanism is provided in the supplied text.	0.4032
34243823	Human genomics	2021	High-throughput screening of circRNAs reveals novel mechanisms of tuberous sclerosis complex-related renal angiomyolipoma.		circRNA_100822			TSC-related renal angiomyolipoma 	MONDO:0004555	kidney angiomyolipoma	down-regulated	RT-qPCR; Microarray	circRNA_100822 is down-regulated in TSC-RAML and was experimentally confirmed by q-PCR as part of the study's ceRNA network; the provided text does not report its specific targets or functional pathway.	0.4032
34243823	Human genomics	2021	High-throughput screening of circRNAs reveals novel mechanisms of tuberous sclerosis complex-related renal angiomyolipoma.		circRNA_100719			TSC-related renal angiomyolipoma 	MONDO:0004555	kidney angiomyolipoma	down-regulated	RT-qPCR; Microarray	circRNA_100719 is down-regulated in TSC-RAML and was confirmed by q-PCR as part of the ceRNA network; no specific interacting miRNA/mRNA or biological function is described in the provided text.	0.4032
34245111	The Kaohsiung journal of medical sciences	2021	Hsa-circ_0000064 accelerates the malignant progression of gastric cancer via sponging microRNA-621.	hsa_circ_0000064	hsa-circ_0000064 			gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_0000064 is up-regulated in gastric cancer and promotes GC cell proliferation, migration, and invasion. Mechanistically, it sponges miR-621 to relieve repression of SYF2, forming a circ_0000064/miR-621/SYF2 ceRNA axis, and high expression is associated with worse overall survival."	0.7779
34249089	Frontiers in genetics	2021	Circ_0124644 Serves as a ceRNA for miR-590-3p to Promote Hypoxia-Induced Cardiomyocytes Injury via Regulating SOX4.	hsa_circ_0124644	circ_0124644	hsa_circ_ROBO2	ROBO2	acute myocardial infarction 	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR	"circ_0124644 is upregulated in AMI patient serum and in hypoxia-treated AC16 cardiomyocytes, where it promotes hypoxia-induced injury. Mechanistically, it acts as a ceRNA that sponges miR-590-3p, thereby increasing SOX4 and aggravating apoptosis/oxidative stress and cell-cycle impairment; circ_0124644 knockdown is protective."	0.8267
34250012	Frontiers in molecular biosciences	2021	Circular RNA TLK1 Promotes Sepsis-Associated Acute Kidney Injury by Regulating Inflammation and Oxidative Stress Through miR-106a-5p/HMGB1 Axis.		circTLK1 	hsa_circ_TLK1	TLK1	sepsis-associated acute kidney injury 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR	"circTLK1 is up-regulated in sepsis-associated AKI models and promotes kidney injury. Mechanistically, it acts as a ceRNA to sponge miR-106a-5p, thereby increasing HMGB1 and enhancing inflammation, oxidative stress, and apoptosis; circTLK1 knockdown alleviates these effects in vivo and in HK-2 cells."	0.6542
34252882	Aging	2021	Circular RNA circCCDC66 promotes glioma proliferation by acting as a ceRNA for miR-320a to regulate FOXM1 expression.		circCCDC66	hsa_circ_CCDC66	CCDC66	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circCCDC66 is up-regulated in glioma tissues/cell lines and functions as an oncogenic circRNA. It promotes proliferation, migration and invasion by acting as a ceRNA that sponges miR-320a, thereby increasing FOXM1 expression."	0.6369
34253241	Journal of experimental & clinical cancer research : CR	2021	EIF4A3-induced circ_0084615 contributes to the progression of colorectal cancer via miR-599/ONECUT2 pathway.	hsa_circ_0084615	circ_0084615	hsa_circ_ASPH	ASPH	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0084615 (ASPH-derived) is up-regulated in colorectal cancer and functions as an oncogenic circRNA. It promotes proliferation, migration/invasion, EMT-related changes and angiogenesis, at least partly by sponging miR-599 to increase ONECUT2, and its biogenesis is positively regulated by the RBP EIF4A3."	0.873
34256841	Stem cell research & therapy	2021	Exosome-transported circRNA_0001236 enhances chondrogenesis and suppress cartilage degradation via the miR-3677-3p/Sox9 axis.	hsa_circ_0001236	circRNA_0001236 	hsa_circ_ZC3H7B	ZC3H7B	osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR; Northern Blot; ISH; Microarray	"Exosomal circ_0001236 (circZC3H7B) is reduced in OA cartilage compared with healthy cartilage. It functions as a ceRNA sponge for miR-3677-3p to increase Sox9 and cartilage matrix markers (e.g., Col2a1) and decrease MMP13, thereby promoting chondrogenesis and inhibiting cartilage degradation; circ_0001236-overexpressing MSC exosomes attenuate OA in the DMM mouse model."	0.8087
34257163	Aging	2021	CircRNA FUT10 regulates the regenerative potential of aged skeletal muscle stem cells by targeting HOXA9.		circRNA FUT10 	mmu_circ_FUT10	FUT10	SkMSC aging 			up-regulated	RT-qPCR; Microarray	"circRNA FUT10 is up-regulated in aged mouse SkMSCs and suppresses SkMSC proliferation and differentiation. Mechanistically, it functions as a ceRNA by sponging miR-365a-3p, thereby relieving repression of HOXA9 and contributing to SkMSC aging; the circRNA FUT10/miR-365a-3p/HOXA9 axis is proposed as a therapeutic target for degenerative muscle disease."	0.6528
34257379	Scientific reports	2021	Identification and characterization of a novel Epstein-Barr Virus-encoded circular RNA from LMP-2 Gene.		circLMP-2_e5		LMP-2	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	dysregulated	RT-qPCR; RNA-seq	"circLMP-2_e5 is a bona fide EBV-encoded circRNA derived from LMP-2 exon 5, detected across EBV-positive cell lines with differential expression between NPC cells (lower) and B cells (higher) and localization in both nucleus and cytoplasm. Functional assays in B-cell lines indicate it does not significantly regulate proliferation, innate immune gene expression, linear LMP-2 transcripts, or EBV lytic reactivation, while its biogenesis may relate to exon 5 skipping with short flanking introns sufficient for circularization."	0.6631
34257535	Pathology oncology research : POR	2021	"Hsa_circ_0043265 Restrains Cell Proliferation, Migration and Invasion of Tongue Squamous Cell Carcinoma via Targeting the miR-1243/SALL1 Axis."	hsa_circ_0043265	circ_0043265			tongue squamous cell carcinoma 	MONDO:0000500	tongue squamous cell carcinoma	down-regulated	RT-qPCR	"circ_0043265 is down-regulated in TSCC tissues and cell lines and functions as a tumor suppressor by inhibiting proliferation, migration, and invasion. Mechanistically, it sponges miR-1243 to relieve repression of SALL1, forming a circ_0043265/miR-1243/SALL1 ceRNA axis; higher circ_0043265 expression correlates with better overall survival."	0.7752
34257702	Computational and mathematical methods in medicine	2021	Circular RNA circFAT1(e2) Promotes Colorectal Cancer Tumorigenesis via the miR-30e-5p/ITGA6 Axis.		circFAT1(e2)	hsa_circ_FAT1	FAT1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circFAT1(e2) is up-regulated in colorectal cancer tissues/cell lines and functions as an oncogenic circRNA. It sponges miR-30e-5p to relieve repression of ITGA6, thereby promoting CRC cell proliferation, migration, and invasion in vitro."	0.6369
34258149	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2021	HNRNPL Circularizes ARHGAP35 to Produce an Oncogenic Protein.		circARHGAP35	hsa_circ_ARHGAP35	ARHGAP35	hepatocellular carcinoma	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Northern Blot; RNA-seq	"circARHGAP35 (from ARHGAP35 exon2_exon3 back-splicing) is up-regulated in HCC and CRC and promotes proliferation, migration, invasion, and metastasis. It is m6A-dependently translated into a truncated oncogenic protein that interacts with TFII-I in the nucleus, and its biogenesis is promoted by the RBP HNRNPL; high circARHGAP35 predicts worse survival in HCC patients."	0.892
34258149	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2021	HNRNPL Circularizes ARHGAP35 to Produce an Oncogenic Protein.		circARHGAP35	hsa_circ_ARHGAP35	ARHGAP35	colorectal cancer	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Northern Blot; RNA-seq	"circARHGAP35 (from ARHGAP35 exon2_exon3 back-splicing) is up-regulated in HCC and CRC and promotes proliferation, migration, invasion, and metastasis. It is m6A-dependently translated into a truncated oncogenic protein that interacts with TFII-I in the nucleus, and its biogenesis is promoted by the RBP HNRNPL; high circARHGAP35 predicts worse survival in HCC patients."	0.892
34258151	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2021	circFAT1 Promotes Cancer Stemness and Immune Evasion by Promoting STAT3 Activation.		circular RNA FAT1	hsa_circ_FAT1	FAT1	head and neck squamous cell carcinoma 	MONDO:0010150	head and neck squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circFAT1 is up-regulated in HNSCC and promotes tumor growth, invasion, cancer stemness, and immune evasion. It acts mainly in the cytoplasm by binding STAT3 and blocking SHP1-mediated STAT3 dephosphorylation, thereby sustaining STAT3 activation and suppressing STAT1-driven type I IFN transcription; circFAT1 knockdown increases CD8+ T-cell infiltration and improves anti-PD1 efficacy."	0.8726
34258151	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2021	circFAT1 Promotes Cancer Stemness and Immune Evasion by Promoting STAT3 Activation.		circRNA Fat1	mmu_circ_Fat1	Fat1	head and neck squamous cell carcinoma 	MONDO:0010150	head and neck squamous cell carcinoma	unknown	RT-qPCR	"In the murine HNSCC model, circFat1 supports tumor growth and immune evasion; its knockdown reduces pSTAT3, increases intratumoral CD8+ T-cell infiltration, promotes tumor apoptosis, and sensitizes tumors to anti-PD1 treatment."	0.7039
34258296	Journal of immunology research	2021	Circ_0044516 Regulates miR-136/MAT2A Pathway to Facilitate Lung Cancer Development.	hsa_circ_0044516	circ_0044516 			lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circ_0044516 is up-regulated in lung cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation, invasion, stemness and tumor growth by sponging miR-136 to increase MAT2A expression."	0.7052
34258297	Journal of immunology research	2021	circSLC6A6 Sponges miR-497-5p to Promote Endometrial Cancer Progression via the PI4KB/Hedgehog Axis.	hsa_circ_0064428	circSLC6A6 	hsa_circ_SLC6A6	SLC6A6	endometrial cancer 	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR; RNA-seq	"circSLC6A6 is up-regulated in endometrial cancer tissues and cell lines and promotes proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, it sponges miR-497-5p to upregulate PI4KB and activate Hedgehog signaling, forming a circSLC6A6/miR-497-5p/PI4KB-Hedgehog axis with potential biomarker value."	0.8171
34258391	"Open medicine (Warsaw, Poland)"	2021	"Circular RNA VANGL1 knockdown suppressed viability, promoted apoptosis, and increased doxorubicin sensitivity through targeting miR-145-5p to regulate SOX4 in bladder cancer cells."	hsa_circ_0002623	circRNA VANGL1 	hsa_circ_VANGL1	VANGL1	bladder cancer	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circ_VANGL1 is up-regulated in bladder cancer tissues and cells. It promotes cell viability and tumor growth, inhibits apoptosis, and reduces doxorubicin sensitivity by sponging miR-145-5p to upregulate SOX4."	0.6521
34262342	Cancer management and research	2021	Circular RNA Circ_0003221 Promotes Cervical Cancer Progression by Regulating miR-758-3p/CPEB4 Axis.	hsa_circ_0003221	circ_0003221 	hsa_circ_PTK2	PTK2	cervical cancer	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ_0003221 is up-regulated in cervical cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation, migration, invasion, EMT and tumor growth by sponging miR-758-3p to increase CPEB4 expression (circ_0003221/miR-758-3p/CPEB4 axis)."	0.7094
34262589	Frontiers in genetics	2021	Analysis of Age-Related Circular RNA Expression Profiles in Mesenchymal Stem Cells of Rat Bone Marrow.		Circ-Phldb2	rno_circ_PHLDB2	Phldb2	age-associated MSC senescence 			up-regulated	RT-qPCR; RNA-seq	"Circ-Phldb2 is significantly up-regulated in aged rat bone marrow MSCs and is proposed to participate in MSC senescence. It may act within a circRNA_miRNA_mRNA network by binding rno-miR-130a-5p/rno-miR-134-5p/rno-miR-208a-5p and thereby potentially influencing target mRNAs such as Ces2h, Tmem47 and Nova1."	0.3684
34262589	Frontiers in genetics	2021	Analysis of Age-Related Circular RNA Expression Profiles in Mesenchymal Stem Cells of Rat Bone Marrow.		circ-Mdm2	rno_circ_MDM2	Mdm2	age-associated MSC senescence 			down-regulated	RT-qPCR; RNA-seq	circ-Mdm2 is down-regulated in aged rat bone marrow MSCs compared with young controls. The study does not report specific downstream miRNA/mRNA targets or pathways for circ-Mdm2.	0.3213
34262589	Frontiers in genetics	2021	Analysis of Age-Related Circular RNA Expression Profiles in Mesenchymal Stem Cells of Rat Bone Marrow.		circ-Rab31	rno_circ_RAB31	Rab31	age-associated MSC senescence 			down-regulated	RT-qPCR; RNA-seq	circ-Rab31 is down-regulated in aged rat bone marrow MSCs compared with young controls. The study does not provide a specific mechanism or downstream targets for circ-Rab31.	0.3213
34268375	Annals of translational medicine	2021	Hsa_circ_0080229 upregulates the expression of murine double minute-2 (MDM2) and promotes glioma tumorigenesis and invasion via the miR-1827 sponging mechanism.	hsa_circ_0080229	circ_0080229 	hsa_circ_EGFR	EGFR	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR; ISH	"circ_0080229 (EGFR-derived) is up-regulated in glioma tissues and cell lines and mainly localizes in the cytoplasm. It promotes glioma proliferation, migration/invasion and tumor growth by sponging miR-1827, thereby increasing MDM2 and affecting downstream p53 signaling; it is proposed as a prognostic/diagnostic biomarker."	0.7739
34271919	Cancer cell international	2021	Circular RNA-DPP4 serves an oncogenic role in prostate cancer progression through regulating miR-195/cyclin D1 axis.	hsa_circ_0056881	circDPP4 	hsa_circ_DPP4	DPP4	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	"circDPP4 (hsa_circ_0056881, derived from DPP4) is up-regulated in prostate cancer tissues and cell lines and promotes malignant phenotypes including proliferation, migration, invasion, and cell cycle progression. Mechanistically, it acts as a ceRNA for miR-195, relieving miR-195-mediated repression of cyclin D1 and thereby enhancing tumor growth."	0.7916
34271943	Journal of experimental & clinical cancer research : CR	2021	Circular RNA circ_001422 promotes the progression and metastasis of osteosarcoma via the miR-195-5p/FGF2/PI3K/Akt axis.		circ_001422	hsa_circ_NSD2	NSD2	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; RNA-seq	"circ_001422 is up-regulated in osteosarcoma tissues and cell lines and promotes proliferation, migration/invasion, and metastasis while inhibiting apoptosis. It functions mainly in the cytoplasm as a ceRNA that sponges miR-195-5p, thereby upregulating FGF2 and activating PI3K/Akt signaling, and its high expression is associated with poor overall survival and diagnostic value."	0.8981
34271965	Journal of orthopaedic surgery and research	2021	Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in postmenopausal osteoporosis.	hsa_circ_0000471	circ_0000471			postmenopausal osteoporosis 	MONDO:0008159	postmenopausal osteoporosis	up-regulated	RT-qPCR; RNA-seq	"circ_0000471 (hsa_circ_0000471) is up-regulated in PBMCs from PMOP patients versus controls based on RNA-seq and was validated by qRT-PCR. Its downstream miRNA/mRNA interactions were not specified individually, but it contributes to the study¡¯s predicted circRNA_miRNA_mRNA (ceRNA) regulatory landscape in PMOP."	0.4032
34271965	Journal of orthopaedic surgery and research	2021	Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in postmenopausal osteoporosis.	hsa_circ_0008139	circ_0008139			postmenopausal osteoporosis 	MONDO:0008159	postmenopausal osteoporosis	up-regulated	RT-qPCR; RNA-seq	"circ_0008139 (hsa_circ_0008139) is up-regulated in PBMCs from PMOP patients versus controls based on RNA-seq and was validated by qRT-PCR. Specific downstream targets were not detailed for this circRNA, but it is part of the study¡¯s predicted ceRNA network in PMOP."	0.4032
34271965	Journal of orthopaedic surgery and research	2021	Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in postmenopausal osteoporosis.	hsa_circ_0001824	circ_0001824			postmenopausal osteoporosis 	MONDO:0008159	postmenopausal osteoporosis	up-regulated	RT-qPCR; RNA-seq	circ_0001824 (hsa_circ_0001824) is up-regulated in PBMCs from PMOP patients versus controls based on RNA-seq and was validated by qRT-PCR. It is included among the dysregulated circRNAs underpinning the predicted circRNA_miRNA_mRNA (ceRNA) regulatory mechanism in PMOP.	0.4032
34271965	Journal of orthopaedic surgery and research	2021	Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in postmenopausal osteoporosis.	hsa_circ_0008345	circ_0008345			postmenopausal osteoporosis 	MONDO:0008159	postmenopausal osteoporosis	up-regulated	RT-qPCR; RNA-seq	circ_0008345 is up-regulated in PBMCs from PMOP patients versus controls by RNA-seq and its dysregulation was validated by qRT-PCR. No specific miRNA/mRNA targets were reported for this circRNA in the provided text.	0.4032
34271965	Journal of orthopaedic surgery and research	2021	Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in postmenopausal osteoporosis.	hsa_circ_0112054	circ_0112054			postmenopausal osteoporosis 	MONDO:0008159	postmenopausal osteoporosis	down-regulated	RT-qPCR; RNA-seq	circ_0112054 is down-regulated in PBMCs from PMOP patients versus controls by RNA-seq and its dysregulation was validated by qRT-PCR. No specific miRNA/mRNA targets were reported for this circRNA in the provided text.	0.4032
34271965	Journal of orthopaedic surgery and research	2021	Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in postmenopausal osteoporosis.	hsa_circ_0000443	circ_0000443			postmenopausal osteoporosis 	MONDO:0008159	postmenopausal osteoporosis	down-regulated	RT-qPCR; RNA-seq	circ_0000443 is down-regulated in PBMCs from PMOP patients versus controls by RNA-seq and its dysregulation was validated by qRT-PCR. No specific miRNA/mRNA targets were reported for this circRNA in the provided text.	0.4032
34271965	Journal of orthopaedic surgery and research	2021	Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in postmenopausal osteoporosis.	hsa_circ_0077548	circ_0077548			postmenopausal osteoporosis 	MONDO:0008159	postmenopausal osteoporosis	down-regulated	RT-qPCR; RNA-seq	circ_0077548 is down-regulated in PBMCs from PMOP patients versus controls by RNA-seq and its dysregulation was validated by qRT-PCR. No specific miRNA/mRNA targets were reported for this circRNA in the provided text.	0.4032
34271965	Journal of orthopaedic surgery and research	2021	Identification and comparison of novel circular RNAs with associated co-expression and competing endogenous RNA networks in postmenopausal osteoporosis.	hsa_circ_0001395	circ_0001395			postmenopausal osteoporosis 	MONDO:0008159	postmenopausal osteoporosis	down-regulated	RT-qPCR; RNA-seq	circ_0001395 is down-regulated in PBMCs from PMOP patients versus controls by RNA-seq and its dysregulation was validated by qRT-PCR. No specific miRNA/mRNA targets were reported for this circRNA in the provided text.	0.4032
34272768	Journal of clinical laboratory analysis	2021	Hsa_circ_0054633 association of C peptide is related to IL-17 and TNF-alpha in patients with diabetes mellitus receiving insulin treatment.	hsa_circ_0054633				type 2 diabetes 	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RT-qPCR	"This study measured serum hsa_circ_0054633 in T2D/IR patients and found it significantly decreased after insulin therapy. Its level negatively correlated with C peptide and positively correlated with IL-17 and TNF-alpha, supporting its potential as a biomarker of insulin treatment effect and inflammatory status."	0.459
34274912	Balkan medical journal	2021	CircCCT3 Acts as a Sponge of miR-613 to Promote Tumor Growth of Pancreatic Cancer Through Regulating VEGFA/VEGFR2 Signaling.	hsa_circ_0004680	CircCCT3	hsa_circ_CCT3	CCT3	pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"CircCCT3 is upregulated in pancreatic cancer and promotes proliferation, migration, invasion and tumor growth while suppressing apoptosis. Mechanistically it sponges miR-613 to increase VEGFA/VEGFR2 expression and enhance VEGFA/VEGFR2 signaling, and high CircCCT3 predicts poor prognosis."	0.7944
34276342	Frontiers in aging neuroscience	2021	Circulating CircRNAs Panel Acts as a Biomarker for the Early Diagnosis and Severity of Parkinson's Disease.	hsa_circ_0085869	circ_0085869			Parkinson's disease 	MONDO:0005180	Parkinson disease	up-regulated	RT-qPCR; Microarray	circ_0085869 is elevated in PD plasma and increases with Hoehn & Yahr stage. It contributes to a circulating circRNA panel that can help distinguish late-stage PD from early-stage PD for disease progression monitoring.	0.5047
34276342	Frontiers in aging neuroscience	2021	Circulating CircRNAs Panel Acts as a Biomarker for the Early Diagnosis and Severity of Parkinson's Disease.	hsa_circ_0004381	circ_0004381			Parkinson's disease 	MONDO:0005180	Parkinson disease	up-regulated	RT-qPCR; Microarray	"circ_0004381 is upregulated in PD plasma and increases with disease stage. It shows diagnostic value for early-stage PD and, together with other circRNAs, helps stratify PD severity (late vs early stage)."	0.5047
34276342	Frontiers in aging neuroscience	2021	Circulating CircRNAs Panel Acts as a Biomarker for the Early Diagnosis and Severity of Parkinson's Disease.	hsa_circ_0017204	circ_0017204			Parkinson's disease 	MONDO:0005180	Parkinson disease	up-regulated	RT-qPCR; Microarray	circ_0017204 is upregulated in PD plasma and rises with PD stage. It has diagnostic value for early-stage PD and contributes to a multi-circRNA panel for distinguishing late-stage from early-stage PD.	0.5047
34276342	Frontiers in aging neuroscience	2021	Circulating CircRNAs Panel Acts as a Biomarker for the Early Diagnosis and Severity of Parkinson's Disease.	hsa_circ_0090668	circ_0090668			Parkinson's disease 	MONDO:0005180	Parkinson disease	up-regulated	RT-qPCR; Microarray	circ_0090668 is upregulated in PD plasma and increases with disease stage. It is part of a circulating circRNA panel that can help monitor PD progression by distinguishing late-stage from early-stage PD.	0.5047
34277611	Frontiers in cell and developmental biology	2021	CircSNHG5 Sponges Mir-495-3p and Modulates CITED2 to Protect Cartilage Endplate From Degradation.	hsa_circ_0077254	circSNHG5	hsa_circ_SNHG5	SNHG5	Intervertebral disc degeneration 	MONDO:0011385	intervertebral disk degenerative disorder	down-regulated	RT-qPCR; Microarray	"circSNHG5 is downregulated in degenerative cartilage endplate tissues in IDD/DCM patients. Functionally, circSNHG5 supports chondrocyte proliferation and protects ECM from degradation by sponging miR-495-3p and regulating the downstream target CITED2."	0.7489
34277611	Frontiers in cell and developmental biology	2021	CircSNHG5 Sponges Mir-495-3p and Modulates CITED2 to Protect Cartilage Endplate From Degradation.	hsa_circ_0077257				Intervertebral disc degeneration 	MONDO:0011385	intervertebral disk degenerative disorder	down-regulated	RT-qPCR; Microarray	"hsa_circ_0077257 was selected from the top downregulated circRNAs and its decreased expression in degenerative CEP tissues was validated by qRT-PCR, but no functional/mechanistic experiments were reported for it."	0.3588
34277611	Frontiers in cell and developmental biology	2021	CircSNHG5 Sponges Mir-495-3p and Modulates CITED2 to Protect Cartilage Endplate From Degradation.	hsa_circ_0071102				Intervertebral disc degeneration 	MONDO:0011385	intervertebral disk degenerative disorder	down-regulated	RT-qPCR; Microarray	hsa_circ_0071102 was among the downregulated circRNAs in degenerative CEP tissues and its decrease was confirmed by qRT-PCR; no downstream targets or functional assays were reported for this circRNA.	0.3588
34278492	Molecular medicine reports	2021	hsa_circ_0101119 facilitates the progression of cervical cancer via an interaction with EIF4A3 to inhibit TCEAL6 expression.	hsa_circ_0101119	hsa_ circ_0101119			cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0101119 is upregulated in cervical cancer and acts as an oncogenic circRNA by promoting proliferation, migration and invasion while inhibiting apoptosis. Mechanistically, it binds/recruits EIF4A3 to suppress TCEAL6 expression by enhancing EIF4A3 interaction with TCEAL6 mRNA and inhibiting TCEAL6 translation."	0.7295
34278876	Technology in cancer research & treatment	2021	Circular RNA BMI1 Serves as a Potential Target for Diagnosis and Treatment in Esophageal Cancer.	hsa_circ_0093335		hsa_circ_BMI1	BMI1	esophageal cancer	MONDO:0007576	esophageal cancer	down-regulated	RT-qPCR	"circ-BMI1 (derived from BMI1 exons 6-12) is down-regulated in esophageal cancer tissues and patient serum. Its overexpression in Eca109 cells suppresses proliferation, migration, colony formation and xenograft tumor growth, and increases sensitivity to 5-fluorouracil and cisplatin, suggesting diagnostic and therapeutic potential."	0.6211
34281396	mBio	2021	A Novel Intronic Circular RNA Antagonizes Influenza Virus by Absorbing a microRNA That Degrades CREBBP and Accelerating IFN-beta Production.		AIVR 	hsa_circ_PRKAR1B	PRKAR1B	influenza virus infection 	MONDO:0005812	influenza	up-regulated	RT-qPCR; RNA-seq	"AIVR is a novel human intronic circRNA induced by influenza virus infection in A549 cells. It localizes mainly in the cytoplasm and acts as a miRNA sponge for miR-330-3p, thereby increasing CREBBP expression and enhancing IFN-beta production to antagonize influenza virus replication."	0.7666
34281530	Cancer cell international	2021	CircFBXL5 promotes the 5-FU resistance of breast cancer via modulating miR-216b/HMGA2 axis.	hsa_circ_0125597		hsa_circ_FBXL5	FBXL5	breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circFBXL5 is up-regulated in breast cancer, especially in 5-FU-resistant cells, and promotes 5-FU resistance, migration/invasion, and tumor growth while inhibiting apoptosis. Mechanistically, it sponges miR-216b to de-repress HMGA2, forming a circFBXL5/miR-216b/HMGA2 axis."	0.7416
34284793	Journal of translational medicine	2021	Hsa_circ_0000520 overexpression increases CDK2 expression via miR-1296 to facilitate cervical cancer cell proliferation.	hsa_circ_0000520		hsa_circ_RPPH1	RPPH1	cervical cancer	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000520 is up-regulated in cervical cancer tissues and cell lines and mainly localized in the cytoplasm. It promotes proliferation and cell-cycle progression and inhibits apoptosis by acting as an Ago2-associated sponge of miR-1296, thereby increasing CDK2 expression; knockdown suppresses xenograft tumor growth."	0.7396
34285193	Cell death & disease	2021	High-throughput sequencing identified circular RNA circUBE2K mediating RhoA associated bladder cancer phenotype via regulation of miR-516b-5p/ARHGAP5 axis.	hsa_circ_0009154		hsa_circ_UBE2K	UBE2K	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circUBE2K (hsa_circ_0009154), derived from UBE2K, is up-regulated in bladder cancer and mainly localized in the cytoplasm. It promotes proliferation, migration/invasion, EMT and metastasis by acting as a ceRNA that sponges miR-516b-5p to increase ARHGAP5, thereby modulating RhoA activity; high circUBE2K associates with poor overall survival."	0.8871
34285578	Cancer management and research	2021	Silencing of circHIPK3 Sensitizes Paclitaxel-Resistant Breast Cancer Cells to Chemotherapy by Regulating HK2 Through Targeting miR-1286.	hsa_circ_0000284		hsa_circ_HIPK3	HIPK3	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in paclitaxel-resistant breast cancer tissues and cells. Functionally, circHIPK3 promotes PTX resistance, while its knockdown sensitizes resistant cells and xenografts to PTX by sponging miR-1286 and thereby increasing HK2 expression, with associated suppression of glycolysis and malignant phenotypes upon circHIPK3 silencing."	0.8174
34287578	Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas	2021	Oncogenic circDHTKD1 promotes tumor growth and metastasis of oral squamous cell carcinoma in vitro and in vivo via upregulating miR-326-mediated GAB1.			hsa_circ_DHTKD1	DHTKD1	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circDHTKD1 is upregulated in OSCC tissues and cell lines and mainly localizes to the cytoplasm. It promotes proliferation, migration/invasion and tumor growth while inhibiting apoptosis by acting as a ceRNA sponge for miR-326 to upregulate GAB1 (circDHTKD1/miR-326/GAB1 axis). Clinically, higher circDHTKD1 expression is associated with advanced clinical stage and larger tumor size."	0.8279
34288804	Bioengineered	2021	Circular RNA hsa_circ_0033144 (CircBCL11B) regulates oral squamous cell carcinoma progression via the miR-579/LASP1 axis.	hsa_circ_0033144	circBCL11B	hsa_circ_BCL11B	BCL11B	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circBCL11B (hsa_circ_0033144) is up-regulated in OSCC tissues and cell lines, mainly localized in the cytoplasm, and its high expression is associated with worse overall survival and more aggressive clinicopathologic features. Functionally, circBCL11B promotes proliferation, migration/invasion and EMT while suppressing apoptosis. Mechanistically, circBCL11B acts as a ceRNA for miR-579 to de-repress LASP1 (circBCL11B/miR-579/LASP1 axis)."	0.8174
34288815	Bioengineered	2021	Circular RNA circRNA_0082835 promotes progression and lymphatic metastasis of primary melanoma by sponging microRNA miRNA-429.	hsa_circ_0082835	circRNA_0082835 	hsa_circ_EZH2	EZH2	primary melanoma 	MONDO:0005105	melanoma	up-regulated	RT-qPCR	"circRNA_0082835 is up-regulated in melanoma and increases with lymphatic metastasis. It promotes melanoma cell proliferation, invasion, migration, cell-cycle progression, Wnt/beta-catenin activity and EMT by sponging miR-429, thereby counteracting miR-429¡¯s anti-tumor effects."	0.6536
34288822	Bioengineered	2021	Circular RNA FAT atypical cadherin 1 (circFAT1)/microRNA-525-5p/spindle and kinetochore-associated complex subunit 1 (SKA1) axis regulates oxaliplatin resistance in breast cancer by activating the notch and Wnt signaling pathway.			hsa_circ_FAT1		breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circFAT1 is upregulated in oxaliplatin-resistant breast cancer tissues/cells and promotes oxaliplatin resistance, migration, and invasion while suppressing apoptosis. Mechanistically, it targets (sponges) miR-525-5p to increase SKA1, which in turn activates Notch and Wnt signaling."	0.5607
34290668	Frontiers in endocrinology	2021	Circular RNA Circ_0067934 Attenuates Ferroptosis of Thyroid Cancer Cells by miR-545-3p/SLC7A11 Signaling.	hsa_circ_0067934	circ_0067934			thyroid cancer	MONDO:0002108	thyroid cancer	up-regulated	RT-qPCR	"circ_0067934 is upregulated in thyroid cancer cell lines and suppresses ferroptosis while promoting cell growth. Mechanistically, it sponges miR-545-3p to relieve repression of SLC7A11, thereby inhibiting ferroptosis and supporting proliferation in vitro and in a nude-mouse xenograft model."	0.5627
34292663	The Kaohsiung journal of medical sciences	2021	Circ_0000317/microRNA-520g/HOXD10 axis affects the biological characteristics of colorectal cancer.	hsa_circ_0000317	circ_0000317 			colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	"circ_0000317 is down-regulated in colorectal cancer tissues and cell lines and acts as a tumor suppressor. It primarily localizes to the cytoplasm and inhibits CRC cell proliferation, migration, invasion, and in vivo metastasis by sponging miR-520g to upregulate HOXD10."	0.697
34294687	Cell death & disease	2021	Autophagy-related circRNA evaluation reveals hsa_circ_0001747 as a potential favorable prognostic factor for biochemical recurrence in patients with prostate cancer.	hsa_circ_0001747		hsa_circ_MKLN1	MKLN1	prostate cancer 	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR	"hsa_circ_0001747 (from MKLN1) is down-regulated in prostate cancer and acts as a protective factor: higher expression predicts longer BCR-free survival. Functionally, its knockdown enhances autophagy flux and promotes PCa cell proliferation and xenograft growth, while autophagy inhibition (CQ) mitigates this effect."	0.6634
34294754	Scientific reports	2021	Circular noncoding RNA hsa_circ_0005986 as a prognostic biomarker for hepatocellular carcinoma.	hsa_circ_0005986	hsa_circ_005986 			hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"hsa_circ_0005986 is down-regulated in HCC tissues and lower in more advanced TNM/BCLC stages. Higher expression predicts better overall and progression-free survival, supporting its role as an independent prognostic biomarker. Bioinformatic analyses further predicted a circRNA_miRNA_mRNA network (including hsa-mir-3677 and hsa-mir-188), suggesting potential involvement in proliferation/inflammation-related processes."	0.6201
34295155	International journal of chronic obstructive pulmonary disease	2021	"Circ-RBMS1 Knockdown Alleviates CSE-Induced Apoptosis, Inflammation and Oxidative Stress via Up-Regulating FBXO11 Through miR-197-3p in 16HBE Cells."	hsa_circ_0002136		hsa_circ_RBMS1	RBMS1	chronic obstructive pulmonary disease 	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR	"circ-RBMS1 is up-regulated in COPD patient samples and in CSE-treated 16HBE cells. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-197-3p, thereby up-regulating FBXO11 to exacerbate CSE-induced apoptosis, inflammation and oxidative stress; circ-RBMS1 knockdown is protective."	0.7631
34295803	Frontiers in oncology	2021	Aberrant Non-Coding RNA Expressed in Gastric Cancer and Its Diagnostic Value.		circASHL2	hsa_circ_ASHL2	ASHL2	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	circASHL2 is down-regulated in gastric cancer tumor tissues versus paired adjacent non-cancer tissues and was selected/validated as an aberrantly expressed circRNA biomarker candidate in this study.	0.3588
34295803	Frontiers in oncology	2021	Aberrant Non-Coding RNA Expressed in Gastric Cancer and Its Diagnostic Value.		circCCDC9	hsa_circ_CCDC9	CCDC9	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	circCCDC9 is down-regulated in gastric cancer tissues and its lower level is associated with higher TNM stage and lymphatic metastasis. It shows a negative correlation with miRNA-6792-3p and was included in a predicted circRNA-miRNA network.	0.4032
34295803	Frontiers in oncology	2021	Aberrant Non-Coding RNA Expressed in Gastric Cancer and Its Diagnostic Value.		circNHSL1	hsa_circ_NHSL1	NHSL1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	circNHSL1 is up-regulated in gastric cancer tissues and is associated with lymphatic metastasis and vascular invasion. It is negatively correlated with miRNA-1306-3p and was included in a predicted circRNA-miRNA network.	0.4032
34295803	Frontiers in oncology	2021	Aberrant Non-Coding RNA Expressed in Gastric Cancer and Its Diagnostic Value.		cirMLLT10	hsa_circ_MLLT10	MLLT10	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	cirMLLT10 is up-regulated in gastric cancer tumor tissues versus paired adjacent non-cancer tissues and was selected/validated as an aberrantly expressed circRNA candidate in this study.	0.3588
34295807	Frontiers in oncology	2021	Circular RNA circ-MMP11 Contributes to Lapatinib Resistance of Breast Cancer Cells by Regulating the miR-153-3p/ANLN Axis.	hsa_circ_0062558	circ-MMP11 	hsa_circ_MMP11	MMP11	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	Circ-MMP11 is up-regulated in lapatinib-resistant breast cancer tissues/cells and can be transported via exosomes. It promotes lapatinib resistance and malignant phenotypes by sponging miR-153-3p and derepressing ANLN; circ-MMP11 knockdown sensitizes cells and xenografts to lapatinib.	0.8353
34296306	Oncology reports	2021	Circular RNA TADA2A promotes proliferation and migration via modulating of miR_638/KIAA0101 signal in non_small cell lung cancer.	hsa_circ_0043278	circTADA2A 	hsa_circ_TADA2A	TADA2A	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circTADA2A is upregulated in NSCLC tissues and cell lines and promotes NSCLC cell proliferation, migration, and invasion. Mechanistically, it mainly localizes to the cytoplasm and acts as a miR-638 sponge to increase KIAA0101 expression, forming a circTADA2A/miR-638/KIAA0101 ceRNA axis. Clinically, higher circTADA2A is associated with advanced disease features and poorer overall survival, with ROC-supported diagnostic potential."	0.8823
34296778	Journal of clinical laboratory analysis	2021	Circular RNA circbeta-catenin aggravates the malignant phenotype of non-small-cell lung cancer via encoding a peptide.		circbeta_catenin	hsa_circ_CTNND1	beta_catenin	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circbeta-catenin is up-regulated in NSCLC tissues/cells and promotes malignant phenotypes (proliferation, migration, invasion, EMT). It encodes a peptide (circbeta-catenin-370aa) that binds GSK3beta, reduces beta-catenin ubiquitination/degradation, and enhances Wnt/beta-catenin signaling."	0.6285
34296783	Journal of clinical laboratory analysis	2021	Lower expression of Hsa_circRNA_102682 in diabetic hyperhomocysteinemia negatively related to creatinemia is associated with TGF-beta and CTGF.		hsa_circRNA_102682 			diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	down-regulated	RT-qPCR	"This study reports that serum Hsa_circRNA_102682 is decreased in diabetic patients with hyperhomocysteinemia and is negatively correlated with Hcy and creatinine. Its level is also negatively correlated with fibrotic factors TGF-beta and CTGF, and it shows high diagnostic performance for DN in ROC analysis."	0.4187
34299096	International journal of molecular sciences	2021	Identification of Novel RNA Binding Proteins Influencing Circular RNA Expression in Hepatocellular Carcinoma.	hsa_circ_0001955				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001955 is up-regulated in HCC and its expression increases upon ESRP2 knockdown in Huh-7 cells, supporting a model where the RBP ESRP2 represses its biogenesis/expression via splicing regulation."	0.3213
34299096	International journal of molecular sciences	2021	Identification of Novel RNA Binding Proteins Influencing Circular RNA Expression in Hepatocellular Carcinoma.	hsa_circ_0008016		hsa_circ_FGFR1	FGFR1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0008016 (from FGFR1) is up-regulated in HCC and increases upon ESRP2 knockdown in Huh-7 cells, consistent with ESRP2 acting as a negative RBP regulator of its biogenesis/expression. ENCODE eCLIP data support binding of PCBP2 near its upstream splice region."	0.4468
34299096	International journal of molecular sciences	2021	Identification of Novel RNA Binding Proteins Influencing Circular RNA Expression in Hepatocellular Carcinoma.	hsa_circ_0008274				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0008274 is up-regulated in HCC and increases upon ESRP2 knockdown in Huh-7 cells, suggesting ESRP2 normally represses its biogenesis/expression via splicing regulation."	0.3213
34299096	International journal of molecular sciences	2021	Identification of Novel RNA Binding Proteins Influencing Circular RNA Expression in Hepatocellular Carcinoma.	hsa_circ_0048492		hsa_circ_MFSD12	MSFD12	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	dysregulated	RT-qPCR; Microarray	"hsa_circ_0048492 shows inconsistent regulation: it is reported as differentially expressed in HCC public datasets but is down-regulated after ESRP2 knockdown in Huh-7 cells, indicating context-dependent ESRP2-mediated circRNA regulation."	0.4468
34301211	BMC cancer	2021	Construction and comprehensive analysis of a ceRNA network to reveal potential prognostic biomarkers for lung adenocarcinoma.	hsa_circ_0049271				lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	down-regulated	Microarray	"This study constructed an ENCORI-based ceRNA network in LUAD centered on the down-regulated circRNA hsa_circ_0049271, linking it to hsa-miR-3127-5p/hsa-miR-1306-5p and seven target mRNAs. Genes in this network were enriched in proliferation-related processes and the JAK-STAT pathway, and reduced hsa_circ_0049271 expression was associated with shorter overall survival."	0.348
34301211	BMC cancer	2021	Construction and comprehensive analysis of a ceRNA network to reveal potential prognostic biomarkers for lung adenocarcinoma.	hsa_circ_0029426				lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	down-regulated	Microarray	"hsa_circ_0029426 was identified as a down-regulated DEcircRNA in LUAD and was included in the constructed ceRNA network, where it may sponge at least one differentially expressed miRNA to regulate 26 DEGs. No experimental validation beyond microarray and computational analyses was reported."	0.1768
34301211	BMC cancer	2021	Construction and comprehensive analysis of a ceRNA network to reveal potential prognostic biomarkers for lung adenocarcinoma.	hsa_circ_0043256				lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	down-regulated	Microarray	"hsa_circ_0043256 was identified as a down-regulated DEcircRNA in LUAD and was included in the constructed ceRNA network, where it may sponge at least one differentially expressed miRNA to regulate 17 DEGs. The paper did not experimentally validate this circRNA beyond microarray and computational analyses."	0.1768
34301266	Molecular cancer	2021	A urine extracellular vesicle circRNA classifier for detection of high-grade prostate cancer in patients with prostate-specific antigen 2-10 ng/mL at initial biopsy.		circPDLIM5	hsa_circ_PDLIM5	PDLIM5	high-grade prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; RNA-seq	circPDLIM5 is elevated in urine extracellular vesicles from patients with high-grade (¡ÝGG2) prostate cancer and is one of five circRNAs used to construct the Ccirc classifier. Its measured level contributes to noninvasive detection and risk prediction of clinically significant PCa at initial biopsy.	0.5414
34301266	Molecular cancer	2021	A urine extracellular vesicle circRNA classifier for detection of high-grade prostate cancer in patients with prostate-specific antigen 2-10 ng/mL at initial biopsy.		circSCAF8	hsa_circ_SCAF8	SCAF8	high-grade prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; RNA-seq	circSCAF8 is increased in urine extracellular vesicles from patients with high-grade (¡ÝGG2) prostate cancer and is included in the 5-circRNA Ccirc model. It contributes to the classifier¡¯s diagnostic performance for predicting clinically significant PCa at initial biopsy.	0.5414
34301266	Molecular cancer	2021	A urine extracellular vesicle circRNA classifier for detection of high-grade prostate cancer in patients with prostate-specific antigen 2-10 ng/mL at initial biopsy.		circPLXDC2	hsa_circ_PLXDC2	PLXDC2	high-grade prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; RNA-seq	circPLXDC2 is elevated in urine extracellular vesicles from high-grade (¡ÝGG2) prostate cancer patients and is a component of the Ccirc diagnostic signature. It contributes to improved noninvasive prediction of clinically significant PCa compared with standard risk calculators.	0.5414
34301266	Molecular cancer	2021	A urine extracellular vesicle circRNA classifier for detection of high-grade prostate cancer in patients with prostate-specific antigen 2-10 ng/mL at initial biopsy.		circSCAMP1	hsa_circ_SCAMP1	SCAMP1	high-grade prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; RNA-seq	circSCAMP1 is upregulated in urine extracellular vesicles from high-grade (¡ÝGG2) prostate cancer patients and is included in the five-circRNA Ccirc classifier. It serves as part of a noninvasive diagnostic signature that improves risk prediction compared with standard clinical calculators.	0.5414
34301266	Molecular cancer	2021	A urine extracellular vesicle circRNA classifier for detection of high-grade prostate cancer in patients with prostate-specific antigen 2-10 ng/mL at initial biopsy.		circCCNT2	hsa_circ_CCNT2	CCNT2	high-grade prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; RNA-seq	circCCNT2 is upregulated in urine extracellular vesicles from high-grade (¡ÝGG2) prostate cancer patients and is one component of the five-circRNA Ccirc classifier. It contributes to improved noninvasive prediction of clinically significant PCa beyond standard risk calculators.	0.5414
34305409	Cancer management and research	2021	The Maturation of Tumor Suppressor miR-497 in Hepatocellular Carcinoma is Inhibited by Oncogenic circRNA SCARB1.		circRNA SCARB1	hsa_circ_SCARB1	SCARB1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circRNA SCARB1 is up-regulated in hepatocellular carcinoma and promotes HCC cell proliferation and migration. Mechanistically, it suppresses the maturation of miR-497 (reducing mature miR-497 without affecting its precursor), and miR-497 overexpression partially rescues SCARB1-driven phenotypes."	0.5546
34306017	Frontiers in genetics	2021	A Novel circRNA-miRNA-mRNA Hub Regulatory Network in Lung Adenocarcinoma.	hsa_circ_0004789		hsa_circ_SMURF2	SMURF2	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; Microarray	hsa_circ_0004789 is down-regulated in LUAD tissues versus adjacent non-tumor tissues and is included in the final ceRNA hub network. It is proposed to act via a ceRNA axis hsa_circ_0004789/hsa-miR-877-5p/C1orf115 in LUAD.	0.4032
34306017	Frontiers in genetics	2021	A Novel circRNA-miRNA-mRNA Hub Regulatory Network in Lung Adenocarcinoma.	hsa_circ_0043256		hsa_circ_ACACA	ACACA	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; Microarray	hsa_circ_0043256 is down-regulated in LUAD tissues versus adjacent non-tumor tissues and is included in the final ceRNA hub network. It is proposed to function through the ceRNA axis hsa_circ_0043256/hsa-miR-4496/PRICKLE2 in LUAD.	0.4032
34306203	Experimental and therapeutic medicine	2021	circRNA_103615 contributes to tumor progression and cisplatin resistance in NSCLC by regulating ABCB1.		circRNA_103615 			non-small cell lung carcinoma 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circRNA_103615 is upregulated in NSCLC tissues and cell lines. Its knockdown suppresses proliferation, migration, invasion and cisplatin resistance while promoting apoptosis, at least partly by reducing ABCB1 expression; ABCB1 overexpression rescues cisplatin resistance."	0.6778
34307012	Journal of bone oncology	2021	CircRERE confers the resistance of multiple myeloma to bortezomib depending on the regulation of CD47 by exerting the sponge effect on miR-152-3p.		circRERE 	hsa_circ_RERE	RERE	multiple myeloma 	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR	"circRERE is up-regulated in bortezomib-resistant multiple myeloma serum and resistant MM cell lines. It promotes BTZ resistance by acting as a ceRNA sponge for miR-152-3p, thereby relieving repression of CD47, enhancing proliferation and reducing apoptosis; higher circRERE levels correlate with chemoresistance and poorer survival."	0.8287
34307356	Frontiers in cell and developmental biology	2021	Exosomes Mediated Transfer of Circ_0000337 Contributes to Cisplatin (CDDP) Resistance of Esophageal Cancer by Regulating JAK2 via miR-377-3p.	hsa_circ_0000337	Circ_0000337	hsa_circ_PPFIA1	PPFIA1	esophageal cancer 	MONDO:0007576	esophageal cancer	up-regulated	RT-qPCR	"Exosomal circ_0000337 is up-regulated in CDDP-resistant esophageal cancer tissues/cells and promotes cisplatin resistance and malignant phenotypes. Mechanistically, it sponges miR-377-3p to derepress JAK2, enhancing tumor growth and CDDP resistance in vitro and in a xenograft model."	0.705
34307457	Frontiers in molecular biosciences	2021	Hsa_circRNA_100146 Promotes Prostate Cancer Progression by Upregulating TRIP13 via Sponging miR-615-5p.		hsa_circRNA_100146 			prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circRNA_100146 is up-regulated in prostate cancer cells and functions as an oncogenic circRNA. It promotes proliferation, migration/invasion, and xenograft tumor growth by sponging miR-615-5p and thereby relieving miR-615-5p-mediated repression of TRIP13."	0.7014
34308761	Bioengineered	2021	Circular RNA circ_0000228 promotes the malignancy of cervical cancer via microRNA-195-5p/ lysyl oxidase-like protein 2 axis.	hsa_circ_0000228	circ_0000228 	hsa_circ_ZEB1	ZEB1	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"circ_0000228 is up-regulated in cervical cancer tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion). It mainly localizes to the cytoplasm and acts as a ceRNA sponging miR-195-5p to increase LOXL2 expression, forming a circ_0000228/miR-195-5p/LOXL2 axis."	0.692
34308775	Bioengineered	2021	Human circular RNA hsa_circRNA_101705 (circTXNDC11) regulates renal cancer progression by regulating MAPK/ERK pathway.		hsa_circRNA_101705 	hsa_circ_TXNDC11	TXNDC11	renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR	"circTXNDC11 (hsa_circRNA_101705), derived from TXNDC11, is up-regulated in RCC tissues and cell lines and correlates with advanced TNM stage and lymph node metastasis. Functionally, circTXNDC11 promotes RCC proliferation and invasion and supports xenograft tumor growth, at least in part by activating MAPK/ERK signaling (increasing p-MEK/p-ERK)."	0.73
34311131	Molecular metabolism	2021	Novel noncoding RNA CircPTK2 regulates lipolysis and adipogenesis in cachexia.	hsa_circ_0005982	CircPTK2 	hsa_circ_PTK2	PTK2	Cancer-associated cachexia 	MONDO:0004992	cancer	up-regulated	RT-qPCR; RNA-seq	"circPTK2 is up-regulated in subcutaneous adipose tissue from cancer-associated cachexia patients and promotes lipolysis while inhibiting adipogenesis. It acts as a ceRNA by sponging miR-182-5p, thereby relieving repression of JAZF1, and shows diagnostic value for CAC in adipose tissue."	0.879
34311131	Molecular metabolism	2021	Novel noncoding RNA CircPTK2 regulates lipolysis and adipogenesis in cachexia.	mmu_circ_0005773	CircPTK2 	mmu_circ_PTK2	PTK2	Cancer-associated cachexia 	MONDO:0004992	cancer	up-regulated	RT-qPCR; RNA-seq	"circPTK2 is up-regulated in subcutaneous adipose tissue from cancer-associated cachexia patients and promotes lipolysis while inhibiting adipogenesis. It acts as a ceRNA by sponging miR-182-5p, thereby relieving repression of JAZF1, and shows diagnostic value for CAC in adipose tissue."	0.879
34311177	"Neoplasia (New York, N.Y.)"	2021	Circ_0089823 reinforces malignant behaviors of non-small cell lung cancer by acting as a sponge for microRNAs targeting SOX4.	hsa_circ_0089823	Circ_0089823	hsa_circ_ARSE	ARSE	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ_0089823 is up-regulated in NSCLC tissues and cell lines and primarily localizes to the cytoplasm. It promotes NSCLC proliferation and tumor growth while inhibiting apoptosis, mainly by sponging miR-507/miR-557/miR-579-3p/miR-1287-5p to up-regulate SOX4."	0.8432
34312371	Cell death discovery	2021	CircPVT1 promotes gallbladder cancer growth by sponging miR-339-3p and regulates MCL-1 expression.		circPVT1	hsa_circ_PVT1	PVT1	gallbladder cancer 	MONDO:0005411	gallbladder cancer	up-regulated	RT-qPCR	"circPVT1 is up-regulated in gallbladder cancer and is associated with lymph node metastasis, advanced TNM stage, and poor overall survival. Functionally, circPVT1 promotes GBC cell proliferation, cell-cycle progression, migration and invasion, and inhibits apoptosis, and its knockdown suppresses xenograft tumor growth. Mechanistically, circPVT1 acts as a cytoplasmic miRNA sponge for miR-339-3p to increase MCL-1 expression (circPVT1/miR-339-3p/MCL-1 axis)."	0.8097
34313353	Journal of clinical laboratory analysis	2021	CircRNA WHSC1 promotes non-small cell lung cancer progression via sponging microRNA-296-3p and up-regulating expression of AKT serine/threonine kinase 3.		circRNA WHSC1 	hsa_circ_WHSC1	WHSC1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	circWHSC1 is up-regulated in NSCLC tissues/cells and predicts poorer overall survival. It promotes proliferation and metastatic phenotypes and inhibits apoptosis by sponging miR-296-3p to up-regulate AKT3.	0.7548
34314379	Aging	2021	Circular RNA circSP3 promotes hepatocellular carcinoma growth by sponging microRNA-198 and upregulating cyclin-dependent kinase 4.		hsa_circSP3 	hsa_circ_SP3	SP3	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circSP3 is up-regulated in hepatocellular carcinoma and promotes tumor cell proliferation, migration/invasion, and xenograft growth. Mechanistically, circSP3 functions as a cytoplasmic sponge for miR-198, thereby de-repressing CDK4 expression to drive HCC progression."	0.8266
34320120	Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas	2021	Circular RNA circEGFR regulates tumor progression via the miR-106a-5p/DDX5 axis in colorectal cancer.	hsa_circ_0080220	circEGFR	hsa_circ_EGFR	EGFR	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circEGFR (hsa_circ_0080220) is up-regulated in colorectal cancer tissues and promotes CRC cell proliferation and invasion/migration in vitro. It functions as a ceRNA by sponging miR-106a-5p, derepressing DDX5 and increasing p-AKT, and higher circEGFR is associated with poorer prognosis and recurrence."	0.7113
34321242	Cancer research	2021	Epstein-Barr Virus-Encoded Circular RNA CircBART2.2 Promotes Immune Escape of Nasopharyngeal Carcinoma by Regulating PD-L1.		circBART2.2 	ebv_circ_BART	BART	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; ISH	"EBV-encoded circBART2.2 is up-regulated in nasopharyngeal carcinoma and promotes immune escape by increasing PD-L1 expression. Mechanistically, circBART2.2 binds the helicase domain of RIG-I, activates IRF3 and NF-kappaB transcriptional programs, and enhances PD-L1 promoter activity, leading to impaired T-cell function in vitro and in a xenograft model."	0.8703
34322376	Frontiers in oncology	2021	Circular RNA TAF4B Promotes Bladder Cancer Progression by Sponging miR-1298-5p and Regulating TGFA Expression.	hsa_circ_0047322	circTAF4B 	hsa_circ_TAF4B	TAF4B	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circTAF4B is up-regulated in bladder cancer and associated with poor prognosis. It promotes tumor cell proliferation, migration/invasion and EMT by sponging miR-1298-5p to increase TGFA expression, and it also enhances tumor growth and EMT in a xenograft model."	0.8571
34324278	Thoracic cancer	2021	Circ_0000520 contributes to triple-negative breast cancer progression through mediating the miR-1296/ZFX axis.	hsa_circ_0000520	circ_0000520	hsa_circ_RPPH1	RPPH1	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"circ_0000520 is up-regulated in TNBC tissues and cell lines and promotes TNBC cell proliferation, migration, invasion and xenograft growth while inhibiting apoptosis. Mechanistically, it acts as a ceRNA that sponges miR-1296 to increase ZFX expression, and high circ_0000520 expression is associated with worse survival."	0.8148
34325714	Molecular cancer	2021	Circular RNA circIKBKB promotes breast cancer bone metastasis through sustaining NF-kappaB/bone remodeling factors signaling.	hsa_circ_0084100	circIKBKB	hsa_circ_IKBKB	IKBKB	breast cancer bone metastasis 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circIKBKB (hsa_circ_0084100, from IKBKB) is up-regulated in bone-metastatic breast cancer and promotes osteolytic bone metastasis. It sustains NF-kappaB signaling by directly interacting with active IKKbeta and p65, disrupting the IkappaBalpha negative feedback loop, and enhances bone remodeling factor (M-CSF/GM-CSF) transcription to drive osteoclastogenesis and pre-metastatic niche formation. High circIKBKB is associated with shorter bone-metastasis-free survival."	0.8793
34326275	Aging	2021	CircSPIDR acts as a tumour suppressor in cervical adenocarcinoma by sponging miR-431-5p and regulating SORCS1 and CUBN expression.		circSPIDR	hsa_circ_SPIDR	SPIDR	cervical adenocarcinoma 	MONDO:0005153	cervical adenocarcinoma	down-regulated	RT-qPCR; Northern Blot; RNA-seq	"circSPIDR is down-regulated in cervical adenocarcinoma and functions as a tumour suppressor. It sponges miR-431-5p to de-repress SORCS1 and CUBN, thereby inhibiting proliferation/colony formation and promoting apoptosis, and it suppresses tumour growth in xenograft models. Clinically, circSPIDR shows diagnostic potential by ROC analysis and correlates with miR-431-5p/SORCS1/CUBN expression in patient tissues."	0.8792
34326381	Scientific reports	2021	Kras-driven intratumoral heterogeneity triggers infiltration of M2 polarized macrophages via the circHIPK3/PTK2 immunosuppressive circuit.		circHIPK3 	hsa_circ_HIPK3	HIPK3	lung cancer 	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	circHIPK3 is upregulated in NSCLC tissues and participates in a circHIPK3/circPTK2-associated immunosuppressive circuit linked to CD163+/CD206+ M2 macrophage infiltration and metastatic progression. Its exosomal presence in serum is associated with advanced-stage (metastatic) NSCLC and shows diagnostic value by ROC/AUC analysis.	0.6028
34326381	Scientific reports	2021	Kras-driven intratumoral heterogeneity triggers infiltration of M2 polarized macrophages via the circHIPK3/PTK2 immunosuppressive circuit.		circPTK2 	hsa_circ_PTK2	PTK2	lung cancer 	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circPTK2 is frequently upregulated in NSCLC tissues and serum exosomes, enriched in metastatic contexts, and is implicated in Kras-related immunosuppressive chemoresistance via M2 macrophage-associated circuits. Silencing circPTK2 (especially combined with M2 macrophage inhibition) reduces tumor growth and metastatic foci and improves survival in mouse models; exosomal circPTK2 also shows diagnostic value for metastatic NSCLC."	0.7169
34328193	Molecular medicine reports	2021	Knockdown of circ_PVT1 inhibits the progression of lung adenocarcinoma and enhances the sensitivity to cisplatin via the miR_429/FOXK1 signaling axis.		circ-PVT1	hsa_circ_PVT1	PVT1	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"circ-PVT1 is upregulated in lung adenocarcinoma cell lines and in cisplatin-resistant A549/DDP cells. Functionally, circ-PVT1 promotes proliferation, migration and invasion, and increases cisplatin resistance by inhibiting DDP-induced apoptosis. Mechanistically, circ-PVT1 acts as a ceRNA to sponge miR-429, thereby upregulating FOXK1 and driving the circ-PVT1/miR-429/FOXK1 axis."	0.5301
34329193	Aging	2021	CircRNA circFOXK2 facilitates oncogenesis in breast cancer via IGF2BP3/miR-370 axis.	hsa_circ_0000816	circFOXK2	hsa_circ_FOXK2	FOXK2	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	"circFOXK2 (hsa_circ_0000816) is up-regulated in highly metastatic breast cancer cells and advanced-stage/metastatic tissues. It promotes migration, invasion, and in vivo metastasis, and mechanistically cooperates with the RBP IGF2BP3 and miR-370; circFOXK2 increases miR-370 and enhances exosomal miR-370 transfer to recipient cells to boost metastatic ability."	0.7618
34330307	Journal of orthopaedic surgery and research	2021	Circ_0025908 regulates cell vitality and proliferation via miR-137/HIPK2 axis of rheumatic arthritis.	hsa_circ_0025908	circ_0025908			Rheumatic arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"circ_0025908 is up-regulated in RA synovial tissues and FLS-RA cells. It promotes RA cell viability/proliferation, cell-cycle progression and inflammatory cytokine production while inhibiting apoptosis by sponging miR-137 to de-repress HIPK2 (circ_0025908/miR-137/HIPK2 axis), with associated activation of NF-kappaB phosphorylation."	0.7294
34336825	Frontiers in cell and developmental biology	2021	Knockdown of Circular RNA hsa_circ_PVT1 Inhibited Laryngeal Cancer Progression via Preventing wnt4/beta-Catenin Signaling Pathway Activation.			hsa_circ_PVT1	PVT1	laryngeal cancer 	MONDO:0002358	laryngeal carcinoma	up-regulated	RT-qPCR; Microarray	"circ_PVT1 is up-regulated in laryngeal cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes LC cell proliferation, cell-cycle progression, migration and invasion while inhibiting apoptosis, at least partly by sponging miR-21-5p to regulate CBX4 and activate Wnt4/beta-catenin signaling; its knockdown suppresses xenograft tumor growth."	0.7492
34336924	Frontiers in molecular biosciences	2021	The Potential Role of hsa_circ_0005505 in the Rupture of Human Intracranial Aneurysm.	hsa_circ_0005505	hsa_circRNA_005505 	hsa_circ_IRAK3	IRAK3	intracranial aneurysm 	MONDO:0005291	brain aneurysm	up-regulated	RT-qPCR; Microarray	"hsa_circ_0005505 is up-regulated in ruptured intracranial aneurysm tissues versus un-ruptured tissues and promotes HBVSMC proliferation and migration while inhibiting apoptosis. It is mainly localized in the cytoplasm and is associated with predicted circRNA-miRNA-mRNA interactions and potential protein-coding capacity; knockdown decreases OPN, YAP1, MMP2 and MMP9 levels."	0.697
34345289	Experimental and therapeutic medicine	2021	Knockdown of circ_0001883 may inhibit epithelial-mesenchymal transition in laryngeal squamous cell carcinoma via the miR-125-5p/PI3K/AKT axis.	hsa_circ_0001883	circ_0001883			laryngeal squamous cell carcinoma 	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR	"circ_0001883 is up-regulated in LSCC tissues and cell lines. Its knockdown suppresses migration, invasion, EMT and tumor growth, at least partly by sponging miR-125b-5p and reducing PI3K/AKT pathway phosphorylation."	0.7471
34345298	Oncology letters	2021	Inhibition of circular RNA_0000285 prevents cell proliferation and induces apoptosis in thyroid cancer by sponging microRNA-654-3p.	hsa_circ_0000285	circRNA_0000285 			thyroid cancer 	MONDO:0002108	thyroid cancer	up-regulated	RT-qPCR	"circRNA_0000285 is up-regulated in thyroid cancer cell lines and promotes malignant phenotypes. Silencing circRNA_0000285 suppresses proliferation and induces apoptosis by sponging miR-654-3p, with associated Bax upregulation and Bcl-2 downregulation; miR-654-3p inhibition reverses these effects."	0.6261
34346842	Bioengineered	2021	A novel fusion circular RNA F-circBA1 derived from the BCR-ABL fusion gene displayed an oncogenic role in chronic myeloid leukemia cells.		F-circBA1 	hsa_circ_BCR-ABL	BCR-ABL	chronic myeloid leukemia 	MONDO:0011996	"chronic myelogenous leukemia, BCR-ABL1 positive"	unknown	RT-qPCR	"F-circBA1 is a BCR-ABL-derived fusion circRNA in CML that promotes CML cell proliferation and leukemogenesis. It mainly functions by sponging miR-148b-3p to increase CDC25B expression, contributing to G2/M cell-cycle regulation. It is detectable in a subset of BCR-ABL-positive CML patient bone marrow samples."	0.8149
34348712	Cancer cell international	2021	"CircFAM13B promotes the proliferation of hepatocellular carcinoma by sponging miR-212, upregulating E2F5 expression and activating the P53 pathway."	hsa_circ_0001535	hsa_circRNA_103951 	hsa_circ_FAM13B	FAM13B	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circFAM13B is up-regulated in HCC tissues/cell lines and promotes HCC cell proliferation and xenograft tumor growth. Mechanistically, it functions as a ceRNA by sponging miR-212-3p to relieve repression of E2F5, thereby suppressing p53 pathway activity (and is also discussed as activating ERK signaling)."	0.8375
34353342	Cancer cell international	2021	Blocking circ-SCMH1 (hsa_circ_0011946) suppresses acquired DDP resistance of oral squamous cell carcinoma (OSCC) cells both in vitro and in vivo by sponging miR-338-3p and regulating LIN28B.	hsa_circ_0011946	circ-SCMH1 	hsa_circ_SCMH1	SCMH1	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circ-SCMH1 is upregulated in DDP-resistant OSCC tissues/cells and promotes cisplatin resistance and malignant phenotypes. It acts as a cytoplasmic ceRNA that sponges miR-338-3p to increase LIN28B, and it can be transferred as an extracellular vesicle cargo to elevate circ-SCMH1 in recipient parental cells."	0.8324
34354043	Cell death & disease	2021	circEVI5 acts as a miR-4793-3p sponge to suppress the proliferation of gastric cancer.	hsa_circ_0013162	circEVI5	hsa_circ_EVI5	EVi5	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; RNA-seq	"circEVI5 is down-regulated in gastric cancer tissues/cells and functions as a tumor suppressor by inhibiting proliferation and inducing G1/S arrest. Mechanistically, it sponges miR-4793-3p to de-repress FOXO1 (and increase p21cip1/p27kip1), and low circEVI5 expression is associated with poorer relapse-free survival."	0.853
34356060	Genes	2021	CircIMPACT: An R Package to Explore Circular RNA Impact on Gene Expression and Pathways.		circHIPK3	hsa_circ_HIPK3	HIPK3	bladder cancer	MONDO:0004986	urinary bladder carcinoma	down-regulated	RNA-seq	"In bladder cancer RNA-seq samples, circHIPK3 is reported as down-regulated. The paper¡¯s case study detects the previously described circHIPK3_miR-558_HPSE axis, consistent with a tumor-suppressive role of circHIPK3 via miR-558 sponging and HPSE repression."	0.1768
34356707	Biosensors	2021	Nanoribbon-Based Electronic Detection of a Glioma-Associated Circular miRNA.	hsa_circ_0005660	NFIX circular RNA 	hsa_circ_NFIX	NFIX	glioma 	MONDO:0021042	glioma	up-regulated	Others	"This study uses SOI nanoribbon biosensor chips to detect human circNFIX (hsa_circ_0005660) in plasma and reports higher circNFIX levels in glioma patient plasma than in control samples, supporting its potential as a liquid-biopsy biomarker for early glioma detection. The paper also notes a reported association of circNFIX with glioma cell proliferation via miR-34a-5p."	0.2629
34363272	Cell biology international	2021	Upregulation of circ-FBL promotes myogenic proliferation in myasthenia gravis by regulation of miR-133/PAX7.	hsa_circ_0051032	circ_FBL	hsa_circ_FBL	FBL	myasthenia gravis 	MONDO:0009688	myasthenia gravis	up-regulated	RT-qPCR; RNA-seq	"circ-FBL (hsa_circ_0051032) is up-regulated in sera from myasthenia gravis patients. Functionally, circ-FBL promotes myoblast proliferation by acting as a ceRNA that sponges miR-133, thereby increasing PAX7 expression."	0.6579
34364402	"Journal of biological research (Thessalonike, Greece)"	2021	CircCNIH4 inhibits gastric cancer progression via regulating DKK2 and FRZB expression and Wnt/beta-catenin pathway.	hsa_circ_0000190	circCNIH4 	hsa_circ_CNIH4	CNIH4	gastric cancer	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"CircCNIH4 (hsa_circ_0000190) is down-regulated in gastric cancer tissues and cell lines and mainly localizes to the cytoplasm. Its overexpression suppresses proliferation/migration/invasion and promotes apoptosis by inhibiting Wnt/beta-catenin signaling, at least partly through upregulating DKK2 and FRZB; DKK2/FRZB knockdown reverses these effects, and circCNIH4 also reduces xenograft tumor growth."	0.7334
34365465	Cell death & disease	2021	Autophagy-associated circular RNA hsa_circ_0007813 modulates human bladder cancer progression via hsa-miR-361-3p/IGF2R regulation.	hsa_circ_0007813		hsa_circ_DHTKD1	DHTKD1	bladder cancer	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"hsa_circ_0007813 is up-regulated in bladder cancer and predicts worse overall survival. It promotes proliferation, migration/invasion, tumor growth and metastasis, and regulates autophagy by sponging hsa-miR-361-3p to increase IGF2R expression."	0.831
34367233	Frontiers in genetics	2021	Circular RNA Circ_0013958 Functions as a Tumor Promoter in Ovarian Cancer by Regulating miR-637/PLXNB2 Axis.	hsa_circ_0013958	circ_0013958 	hsa_circ_ACP6	ACP6	ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circ_0013958 is up-regulated in ovarian cancer tissues and cell lines and acts as a tumor promoter. It mainly localizes in the cytoplasm and functions as a ceRNA by sponging miR-637, thereby increasing PLXNB2 expression to promote proliferation/migration/invasion and inhibit apoptosis; its silencing suppresses xenograft tumor growth."	0.7829
34367259	Frontiers in genetics	2021	The Potential of Serum Exosomal hsa_circ_0028861 as the Novel Diagnostic Biomarker of HBV-Derived Hepatocellular Cancer.	hsa_circ_0028861				HBV-derived hepatocellular cancer 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"Serum exosomal hsa_circ_0028861 is down-regulated in HBV-derived HCC versus chronic HBV/cirrhosis and serves as a diagnostic biomarker, including for small, early-stage, and AFP-negative HCC. Bioinformatics analyses suggest it may regulate target miRNAs and thereby affect tumor-related pathways (e.g., integrin, VEGF, PI3K/Akt, mTOR) potentially influencing HCC progression."	0.5047
34368867	Molecular medicine reports	2021	"circCD151 promotes GLI2 expression by regulating miR_30d_5p and enhancing proliferation, invasion and stemness of lung cancer."		circCD151	hsa_circ_CD151	CD151	lung cancer 	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circCD151 is up-regulated in NSCLC/lung adenocarcinoma tissues and cell lines and mainly localizes to the cytoplasm. It promotes lung cancer cell proliferation, invasion and stemness via a ceRNA axis in which circCD151 sponges miR-30d-5p to increase GLI2 expression."	0.6777
34369654	The Kaohsiung journal of medical sciences	2021	Circular RNA circ_0011385 promotes cervical cancer progression through competitively binding to miR-149-5p and up-regulating SOX4 expression.	hsa_circ_0011385	circ_0011385			cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"circ_0011385 is up-regulated in cervical cancer tissues/cell lines and mainly localizes to the cytoplasm. It promotes malignant phenotypes (proliferation/migration/invasion) and inhibits apoptosis by sponging miR-149-5p, thereby increasing SOX4 expression (circ_0011385/miR-149-5p/SOX4 ceRNA axis)."	0.7884
34370715	Aging	2021	Circular RNA ZNF609 drives tumor progression by regulating the miR-138-5p/SIRT7 axis in melanoma.		circZNF609 	hsa_circ_ZNF609	ZNF609	melanoma	MONDO:0005105	melanoma	unknown	RT-qPCR	"In melanoma A375 and SK-MEL-28 cells, circZNF609 promotes proliferation, migration and invasion and inhibits apoptosis while repressing DNA damage. Mechanistically it functions as a ceRNA by sponging miR-138-5p to maintain SIRT7 expression, and circZNF609 knockdown suppresses tumor growth in a nude mouse xenograft model."	0.5637
34374630	Bioengineered	2021	Upregulated circRNA_102231 promotes gastric cancer progression and its clinical significance.		circRNA_102231			gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circRNA_102231 is up-regulated in gastric cancer tissues and patient plasma and is associated with worse clinical outcomes. It promotes GC proliferation, invasion and tumor growth by binding the oncoprotein IRTKS and increasing its protein stability/half-life, and IRTKS overexpression rescues the effects of circRNA_102231 knockdown."	0.7793
34377022	Cancer management and research	2021	Propofol Suppresses Gastric Cancer Progression by Regulating circPDSS1/miR-1324/SOX4 Axis.	hsa_circ_0093398	circPDSS1	hsa_circ_PDSS1	PDSS1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"In gastric cancer, circPDSS1 is upregulated in tumor tissues and promotes malignant phenotypes. Propofol suppresses GC progression partly by downregulating circPDSS1, which otherwise sponges miR-1324 to increase SOX4 expression and enhance proliferation/migration/invasion while reducing apoptosis."	0.8006
34377026	Cancer management and research	2021	CircTMCO3 Promotes Gastric Cancer Progression by Regulating miR-577/RAB14 Axis.		circTMCO3	hsa_circ_TMCO3	TMCO3	Gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circTMCO3 is up-regulated in gastric cancer tissues and cell lines and promotes GC cell proliferation, migration, and invasion. Mechanistically, it sponges miR-577 to de-repress the miR-577 target RAB14, forming a circTMCO3/miR-577/RAB14 axis that drives oncogenic phenotypes."	0.7369
34381772	Frontiers in cell and developmental biology	2021	CircFAM120B Blocks the Development of Colorectal Cancer by Activating TGF-Beta Receptor II Expression via Targeting miR-645.		circFAM120B 	hsa_circ_FAM120B	FAM120B	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	"In colorectal cancer, circFAM120B is down-regulated and functions as a tumor suppressor. Its overexpression inhibits proliferation, migration/invasion, glycolysis, and xenograft tumor growth by sponging miR-645 to relieve repression of TGFBR2 (circFAM120B/miR-645/TGFBR2 axis)."	0.8197
34384442	Molecular cancer	2021	CircDIDO1 inhibits gastric cancer progression by encoding a novel DIDO1-529aa protein and regulating PRDX2 protein stability.	hsa_circ_0061137	circDIDO1	hsa_circ_DIDO1	DIDO1	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"circDIDO1 (hsa_circ_0061137), derived from DIDO1, is down-regulated in gastric cancer and acts as a tumor suppressor by inhibiting proliferation, migration/invasion and metastasis while promoting apoptosis. It functions through dual mechanisms: encoding a DIDO1-529aa peptide that binds PARP1 to inhibit its activity, and binding PRDX2 to promote RBX1-mediated ubiquitination and proteasomal degradation, leading to inactivation of Wnt/beta-catenin, MAPK and PI3K/AKT signaling."	0.8793
34385405	Aging	2021	Plasmatic exosome-derived circRNAs panel act as fingerprint for glioblastoma.	hsa_circ_0055202	circ_0055202			glioblastoma multiforme 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0055202 is up-regulated in plasma exosomes from GBM patients and shows diagnostic value by ROC analysis. Functionally, knockdown of circ_0055202 in U87 cells reduces GBM cell proliferation, supporting a pro-proliferative role."	0.7242
34385405	Aging	2021	Plasmatic exosome-derived circRNAs panel act as fingerprint for glioblastoma.	hsa_circ_0074920	circ_0074920			glioblastoma multiforme 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0074920 is up-regulated in plasma exosomes from GBM patients and provides modest diagnostic discrimination by ROC analysis. In vitro, circ_0074920 knockdown reduces GBM cell proliferation, indicating a pro-proliferative effect."	0.7242
34385405	Aging	2021	Plasmatic exosome-derived circRNAs panel act as fingerprint for glioblastoma.	hsa_circ_0043722	circ_0043722			glioblastoma multiforme 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0043722 is up-regulated in plasma exosomes from GBM patients and shows high diagnostic value in the training set by ROC analysis. Knockdown of circ_0043722 suppresses GBM cell proliferation in vitro, suggesting it promotes proliferative capacity of GBM cells."	0.7242
34386427	Frontiers in oncology	2021	The Circular RNA circXPO1 Promotes Tumor Growth via Sponging MicroRNA-23a in Prostate Carcinoma.	hsa_circ_0001016	circXPO1 	hsa_circ_XPO1	XPO1	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	circXPO1 is up-regulated in prostate cancer tissues and cell lines and predominantly localized in the cytoplasm. It promotes prostate cancer cell proliferation/colony formation and invasion in vitro and tumor growth in a PC-3 xenograft model by sponging miR-23a and suppressing miR-23a levels.	0.7629
34389711	Nature communications	2021	Nuclear export and translation of circular repeat-containing intronic RNA in C9ORF72-ALS/FTD.			hsa_circ_C9ORF72	C9ORF72	amyotrophic lateral sclerosis 	MONDO:0004976	amyotrophic lateral sclerosis	dysregulated	RT-qPCR; ISH; RNA-seq	"In C9ORF72-ALS/FTD, the GGGGCC repeat-containing spliced intron is stabilized as a circular (lariat-derived) intronic RNA, exported to the cytoplasm via the NXF1-NXT1 pathway, and serves as the template for RAN translation that generates toxic DPR proteins."	0.6731
34390174	The Kaohsiung journal of medical sciences	2021	Circ_0087862 promotes the progression of colorectal cancer by sponging miR-142-3p and up-regulating BACH1 expression.	hsa_circ_0087862	circ_0087862			colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circ_0087862 is up-regulated in colorectal cancer tissues and cell lines and promotes CRC cell proliferation, migration, and invasion. Mechanistically, it functions as a ceRNA by sponging miR-142-3p to up-regulate BACH1."	0.7283
34390329	Aging	2021	"A circular RNA, circSMARCA5, inhibits prostate cancer proliferative, migrative, and invasive capabilities via the miR-181b-5p/miR-17-3p-TIMP3 axis."	hsa_circ_0001445	circSMARCA5 	hsa_circ_SMARCA5	SMARCA5	prostate cancer	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR	"circSMARCA5 is down-regulated in prostate cancer tissues and cell lines and functions as a tumor suppressor. It inhibits proliferation, migration, invasion, and metastasis by sponging miR-181b-5p and miR-17-3p to relieve repression of TIMP3; KAT5 promotes circSMARCA5 biogenesis and impacts this axis."	0.8166
34392306	Cell death discovery	2021	IGF2BP2-modified circular RNA circARHGAP12 promotes cervical cancer progression by interacting m6A/FOXM1 manner.	hsa_circ_0000231	circARHGAP12	hsa_circ_ARHGAP12	ARHGAP12	cervical cancer	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"circARHGAP12 (hsa_circ_0000231), derived from ARHGAP12, is up-regulated in cervical cancer and predicts worse survival. It promotes cervical cancer proliferation, migration, and xenograft growth by binding the m6A reader IGF2BP2 and enhancing FOXM1 mRNA stability (circARHGAP12/IGF2BP2/FOXM1 complex)."	0.8791
34395419	Frontiers in cell and developmental biology	2021	CircGNG4 Promotes the Progression of Prostate Cancer by Sponging miR-223 to Enhance EYA3/c-myc Expression.	hsa_circ_0017076	circGNG4	hsa_circ_GNG4	GNG4	prostate cancer	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circGNG4 is upregulated in prostate cancer and functions as an oncogenic circRNA. It mainly localizes to the cytoplasm and sponges miR-223, thereby increasing EYA3 and promoting c-Myc expression/stability to drive cell-cycle progression and malignant phenotypes (proliferation, migration/invasion, and xenograft growth)."	0.8365
34395434	Frontiers in cell and developmental biology	2021	MiR-92b-3p Inhibits Proliferation of HER2-Positive Breast Cancer Cell by Targeting circCDYL.		circCDYL	hsa_circ_CDYL	CDYL	HER2-positive breast cancer 	MONDO:0006244	HER2 positive breast carcinoma	up-regulated	RT-qPCR; ISH	"circCDYL is up-regulated in HER2+ breast cancer and promotes proliferation and tumorigenesis. Mechanistically, circCDYL activates PI3K/AKT signaling, and it directly binds miR-92b-3p but is degraded via a miR-92b-3p-dependent RISC (AGO2/GW182) mechanism rather than functioning as a miRNA sponge. High circCDYL expression predicts poorer DFS in HER2+ patients."	0.8846
34396434	Oncology reports	2021	Knockdown of circNRIP1 sensitizes colorectal cancer to 5_FU via sponging miR_532_3p.		circNRIP1 	hsa_circ_NRIP1	NRIP1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circNRIP1 is up-regulated in colorectal cancer and behaves as an oncogenic circRNA, promoting proliferation/migration/invasion and inhibiting apoptosis. It decreases CRC cell sensitivity to 5-FU by sponging miR-532-3p; knockdown of circNRIP1 increases miR-532-3p and sensitizes cells to 5-FU. High circNRIP1 is associated with advanced disease features and poor overall survival, with potential diagnostic utility (ROC)."	0.7365
34398999	Journal of clinical laboratory analysis	2021	Reduced expression of circRNA hsa_circ_001888 in gastric cancer and its clinical significance.	hsa_circ_0001228	hsa_circ_001888	hsa_circ_MFNG	MFNG	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"hsa_circ_001888 (MFNG-derived) is significantly down-regulated in gastric cancer cell lines, tumor tissues, and patient plasma, and shows diagnostic potential (ROC AUC ~0.65_0.66). Its expression associates with tumor differentiation in tissues and with serum CEA/CA19-9 status in plasma, but no molecular mechanism was experimentally defined in this study."	0.559
34400892	International journal of medical sciences	2021	MiR-508-3p promotes proliferation and inhibits apoptosis of middle ear cholesteatoma cells by targeting PTEN/PI3K/AKT pathway.	hsa_circ_0000007				middle ear cholesteatoma 	MONDO:0006533	cholesteatoma of middle ear	down-regulated	RT-qPCR; Microarray	"hsa_circ_0000007 is significantly down-regulated in middle ear cholesteatoma tissues/cells. The study proposes a hsa_circ_0000007/miR-508-3p/PTEN regulatory axis linked to the PTEN/PI3K/Akt pathway, suggesting hsa_circ_0000007 may counteract miR-508-3p-driven proliferation and anti-apoptosis effects."	0.4032
34404391	World journal of surgical oncology	2021	Identification of a novel circ_0018289/miR-183-5p/TMED5 regulatory network in cervical cancer development.	hsa_circ_0018289	circ_0018289	hsa_circ_SYT15	SYT15	cervical cancer	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ_0018289 is up-regulated in cervical cancer and acts as an oncogenic circRNA. It promotes proliferation, inhibits apoptosis, enhances angiogenesis and tumor growth by sponging miR-183-5p to derepress TMED5 (circ_0018289/miR-183-5p/TMED5 axis)."	0.7859
34405943	The Kaohsiung journal of medical sciences	2021	"Silencing of circ_0000517 suppresses proliferation, glycolysis, and glutamine decomposition of non-small cell lung cancer by modulating miR-330-5p/YY1 signal pathway."	hsa_circ_0000517	circ_0000517 			non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0000517 is up-regulated in NSCLC tissues and cell lines and its high expression is associated with worse overall survival. Functionally, circ_0000517 promotes NSCLC proliferation, glycolysis and glutamine catabolism and supports xenograft growth by acting as a ceRNA for miR-330-5p to increase YY1."	0.7942
34406978	Aging	2021	Circular RNA circRHOT1 contributes to pathogenesis of non-small cell lung cancer by epigenetically enhancing C-MYC expression through recruiting KAT5.		circRHOT1	hsa_circ_RHOT1	RHOT1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circRHOT1 is up-regulated in NSCLC tumor tissues and lung cancer cell lines and promotes proliferation and tumor growth while suppressing apoptosis. Mechanistically, circRHOT1 binds KAT5 and facilitates its recruitment to the c-MYC promoter, increasing transcription-associated H3K27ac/RNA polymerase II enrichment and elevating c-MYC expression."	0.8151
34407841	Journal of orthopaedic surgery and research	2021	Hsa_circ_0004674 promotes osteosarcoma doxorubicin resistance by regulating the miR-342-3p/FBN1 axis.	hsa_circ_0004674		hsa_circ_ADAM22	ADAM22	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"hsa_circ_0004674 is upregulated in doxorubicin-resistant osteosarcoma tissues and cells and promotes doxorubicin chemoresistance. Mechanistically, it sponges miR-342-3p to upregulate FBN1 and activate Wnt/beta-catenin signaling, thereby enhancing resistance and malignant phenotypes (proliferation, reduced apoptosis)."	0.8118
34410499	Archives of virology	2021	circRNA expression patterns and circRNA-miRNA-mRNA networks during CV-A16 infection of SH-SY5Y cells.	hsa_circ_0004447				CV-A16 infection	MONDO:0005721	coxsackievirus infectious disease	unknown	RNA-seq	hsa_circ_0004447 was identified (by sequencing and bioinformatic network analysis) as part of a circRNA-miRNA-mRNA ceRNA axis that may regulate MMP2 during CV-A16 infection of SH-SY5Y cells.	0.1768
34410499	Archives of virology	2021	circRNA expression patterns and circRNA-miRNA-mRNA networks during CV-A16 infection of SH-SY5Y cells.	hsa_circ_0078617				CV-A16 infection	MONDO:0005721	coxsackievirus infectious disease	unknown	RNA-seq	hsa_circ_0078617 was highlighted by bioinformatic ceRNA network analysis as potentially regulating MMP2 via binding hsa-miR-6780b-5p and/or hsa-miR-5196-5p during CV-A16 infection of SH-SY5Y cells.	0.1768
34410499	Archives of virology	2021	circRNA expression patterns and circRNA-miRNA-mRNA networks during CV-A16 infection of SH-SY5Y cells.	hsa_circ_0000205				CV-A16 infection	MONDO:0005721	coxsackievirus infectious disease	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0000205 is a CV-A16 infection-associated dysregulated circRNA in SH-SY5Y cells, and its differential expression was validated by qRT-PCR consistent with sequencing data."	0.3588
34410499	Archives of virology	2021	circRNA expression patterns and circRNA-miRNA-mRNA networks during CV-A16 infection of SH-SY5Y cells.	hsa_circ_0002485				CV-A16 infection	MONDO:0005721	coxsackievirus infectious disease	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0002485 is a CV-A16 infection-associated dysregulated circRNA in SH-SY5Y cells, and its differential expression was validated by qRT-PCR consistent with sequencing data."	0.3588
34410499	Archives of virology	2021	circRNA expression patterns and circRNA-miRNA-mRNA networks during CV-A16 infection of SH-SY5Y cells.	hsa_circ_0007059				CV-A16 infection	MONDO:0005721	coxsackievirus infectious disease	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0007059 is a CV-A16 infection-associated dysregulated circRNA in SH-SY5Y cells, and its differential expression was validated by qRT-PCR consistent with sequencing data."	0.3588
34410499	Archives of virology	2021	circRNA expression patterns and circRNA-miRNA-mRNA networks during CV-A16 infection of SH-SY5Y cells.	hsa_circ_0002483				CV-A16 infection	MONDO:0005721	coxsackievirus infectious disease	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0002483 is a CV-A16 infection-associated dysregulated circRNA in SH-SY5Y cells, and its differential expression was validated by qRT-PCR consistent with sequencing data."	0.3588
34410499	Archives of virology	2021	circRNA expression patterns and circRNA-miRNA-mRNA networks during CV-A16 infection of SH-SY5Y cells.	hsa_circ_0002301				CV-A16 infection	MONDO:0005721	coxsackievirus infectious disease	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0002301 is a CV-A16 infection-associated dysregulated circRNA in SH-SY5Y cells, and its differential expression was validated by qRT-PCR consistent with sequencing data."	0.3588
34410499	Archives of virology	2021	circRNA expression patterns and circRNA-miRNA-mRNA networks during CV-A16 infection of SH-SY5Y cells.	hsa_circ_0002141				CV-A16 infection	MONDO:0005721	coxsackievirus infectious disease	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0002141 is a CV-A16 infection-associated dysregulated circRNA in SH-SY5Y cells, and its differential expression was validated by qRT-PCR consistent with sequencing data."	0.3588
34410682	Journal of cellular and molecular medicine	2021	CircTLK1 modulates sepsis-induced cardiomyocyte apoptosis via enhancing PARP1/HMGB1 axis-mediated mitochondrial DNA damage by sponging miR-17-5p.		circTLK1 	hsa_circ_TLK1	TLK1	septic cardiomyopathy 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR	"CircTLK1 is up-regulated in LPS-stimulated human cardiomyocytes and in septic rat myocardium. It promotes cardiomyocyte apoptosis by sponging miR-17-5p to increase PARP1, thereby activating the PARP1/HMGB1 axis and aggravating oxidative mtDNA damage and mitochondrial dysfunction."	0.6331
34412616	BMC cancer	2021	Exosomal circEIF3K from cancer-associated fibroblast promotes colorectal cancer (CRC) progression via miR-214/PD-L1 axis.		circEIF3K	hsa_circ_EIF3K	EIF3K	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circEIF3K is enriched in CAF-derived exosomes under hypoxia and promotes CRC malignant phenotypes and xenograft growth. Mechanistically, circEIF3K binds miR-214, leading to increased PD-L1 expression and enhanced CRC progression; higher circEIF3K correlates with advanced stage and poorer survival in TCGA."	0.7032
34412652	Molecular cancer	2021	A novel NF-kappaB regulator encoded by circPLCE1 inhibits colorectal carcinoma progression by promoting RPS3 ubiquitin-dependent degradation.	hsa_circ_0019223	circPLCE1	hsa_circ_PLCE1	PLCE1	colorectal carcinoma 	MONDO:0024331	colorectal carcinoma	down-regulated	RT-qPCR; ISH; RNA-seq	"circPLCE1 is down-regulated in colorectal carcinoma and suppresses malignant phenotypes. It exerts its tumor-suppressive effect mainly by encoding circPLCE1-411, which binds the HSP90alpha/RPS3 complex to promote RPS3 ubiquitin-dependent degradation and inhibit NF-kappaB signaling. Low circPLCE1 levels are associated with advanced stage and worse patient survival."	0.8737
34413269	Aging	2021	Hsa_circ_0134111 promotes osteoarthritis progression by regulating miR-224-5p/CCL1 interaction.	hsa_circ_0134111	hsa-circ-0134111			osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"hsa_circ_0134111 is up-regulated in OA-related settings (OA patient cartilage and IL-1beta-stimulated human chondrocytes). It promotes OA progression by acting as a ceRNA that sponges miR-224-5p, relieving repression of CCL1 (with downstream CCR8-related effects), thereby enhancing chondrocyte apoptosis, suppressing viability/proliferation, and aggravating cartilage damage and inflammation; its knockdown alleviates OA phenotypes in vitro and in a rat OA model."	0.6835
34413875	Frontiers in genetics	2021	SNAI2-Induced CircMTO1 Promotes Cell Proliferation and Inhibits Apoptosis Through the miR-320b/MCL1 Axis in Human Granulosa-Like Tumor Cells.		CircMTO1 	hsa_circ_MTO1	MTO1	Polycystic ovary syndrome 	MONDO:0008487	polycystic ovary syndrome	up-regulated	RT-qPCR	"In insulin-treated human granulosa-like tumor cells (PCOS cellular model), circMTO1 is upregulated and mainly cytoplasmic. circMTO1 promotes proliferation and inhibits apoptosis by acting as a ceRNA that sponges miR-320b to upregulate MCL1, and its expression is induced by the transcription factor SNAI2 via the MTO1 promoter."	0.7836
34413915	Disease markers	2021	"circRNA hsa_circ_0005909 Predicts Poor Prognosis and Promotes the Growth, Metastasis, and Drug Resistance of Non-Small-Cell Lung Cancer via the miRNA-338-3p/SOX4 Pathway."	hsa_circ_0005909	circ_0005909	hsa_circ_XPR1	XPR1	non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0005909 (circ_0005909), derived from XPR1, is up-regulated in NSCLC tissues and cell lines and its high expression predicts shorter overall survival. Functionally it promotes proliferation, invasion/metastasis and adriamycin-related drug resistance, and its knockdown inhibits xenograft tumor growth. Mechanistically, it acts as a ceRNA by sponging miRNA-338-3p to increase SOX4 expression."	0.8353
34414449	Molecular medicine reports	2021	Circular RNA OMA1 regulates the progression of breast cancer via modulation of the miR_1276/SIRT4 axis.	hsa_circ_0000073		hsa_circ_OMA1	OMA1	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circOMA1 (hsa_circRNA_0000073, derived from OMA1) is up-regulated in breast cancer and associated with larger tumor size, lymph node metastasis, and poorer overall survival. It mainly localizes in the cytoplasm and promotes malignant phenotypes by sponging miR-1276 to increase SIRT4 expression, forming a circOMA1/miR-1276/SIRT4 ceRNA axis."	0.8761
34416901	Molecular cancer	2021	N6-methyladenosine-modified circIGF2BP3 inhibits CD8+ T-cell responses to facilitate tumor immune evasion by promoting the deubiquitination of PD-L1 in non-small cell lung cancer.	hsa_circ_0079587		hsa_circ_IGF2BP3	IGF2BP3	non-small-cell lung carcinoma 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circIGF2BP3 is upregulated in NSCLC and suppresses CD8+ T cell-mediated antitumor immunity. It acts as an m6A-regulated cytoplasmic ceRNA that sponges miR-328-3p/miR-3173-5p to increase PKP3, ultimately promoting OTUB1-dependent PD-L1 deubiquitination and tumor immune evasion, and high expression predicts poor overall survival."	0.8816
34416910	Journal of experimental & clinical cancer research : CR	2021	FUS-induced circRHOBTB3 facilitates cell proliferation via miR-600/NACC1 mediated autophagy response in pancreatic ductal adenocarcinoma.	hsa_circ_0007444		hsa_circ_RHOBTB3	RHOBTB3	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circRHOBTB3 is up-regulated in PDAC tissues and cell lines and promotes PDAC cell proliferation and tumor growth. It mainly localizes in the cytoplasm and acts as a ceRNA by sponging miR-600 to maintain NACC1 levels, thereby enhancing autophagy through inhibition of Akt/mTOR signaling; its biogenesis is promoted by the RBP FUS. High circRHOBTB3 expression predicts poor prognosis and is an independent risk factor in a 110-patient cohort."	0.8816
34419070	Molecular cancer	2021	Circular RNA CircEYA3 induces energy production to promote pancreatic ductal adenocarcinoma progression through the miR-1294/c-Myc axis.	hsa_circ_0007895		hsa_circ_EYA3	EYA3	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; ISH	"circEYA3 (hsa_circ_0007895), derived from EYA3 and mainly localized in the cytoplasm, is up-regulated in PDAC tissues/cells and correlates with advanced stage and poorer survival. It promotes PDAC proliferation, migration/invasion, and tumor growth while inhibiting apoptosis by acting as a miR-1294 sponge to increase c-Myc expression, thereby enhancing ATP/energy production."	0.8912
34419106	Journal of translational medicine	2021	Integrated analysis of competing endogenous RNA networks in peripheral blood mononuclear cells of systemic lupus erythematosus.		circRNA2013 			systemic lupus erythematosus 	MONDO:0007915	systemic lupus erythematosus	dysregulated	RT-qPCR; RNA-seq	"circRNA2013 was identified as a differentially expressed circRNA in SLE PBMCs, but its direction was inconsistent between RNA-seq (up) and RT-qPCR validation (down). It was placed in predicted ceRNA sub-networks involving PC-3P-9143_61/IFNAR2 and hsa-mir-6741/nfkb1."	0.4032
34420029	Cell death discovery	2021	CircRNA circ-PDCD11 promotes triple-negative breast cancer progression via enhancing aerobic glycolysis.	hsa_circ_0019853	circPDCD11 	hsa_circ_PDCD11	PDCD11	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; Microarray	"circPDCD11 is upregulated in TNBC and promotes aerobic glycolysis and proliferation, enhancing tumor growth. Mechanistically, it mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-432-5p to increase LDHA expression. High circPDCD11 expression is associated with worse overall survival and may serve as a prognostic biomarker/therapeutic target in TNBC."	0.8222
34420031	Cell death & disease	2021	Hsa_circ_0026628 promotes the development of colorectal cancer by targeting SP1 to activate the Wnt/beta-catenin pathway.	hsa_circ_0026628	circ_0026628	hsa_circ_SP1	SP1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"In colorectal cancer cells, circ_0026628 is upregulated and promotes proliferation, migration, EMT and stemness. It increases SP1 by sponging miR-346 and recruiting FUS to stabilize SP1 mRNA, thereby enhancing SP1/beta-catenin interaction and activating Wnt/beta-catenin signaling; SOX2 provides positive feedback by transcriptionally activating SP1 to elevate circ_0026628."	0.8155
34421353	International journal of biological sciences	2021	Circular RNA circBCBM1 promotes breast cancer brain metastasis by modulating miR-125a/BRD4 axis.	hsa_circ_0001944	circBCBM1 	hsa_circ_FIRRE	FIRRE	breast cancer brain metastasis 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circBCBM1 (hsa_circ_0001944), derived from the FIRRE locus, is upregulated in breast cancer brain metastasis cells, tissues, and patient plasma. It promotes proliferation, migration, tumor growth and brain metastasis by sponging miR-125a to upregulate BRD4, which increases MMP9 via SHH signaling. High circBCBM1 in primary tumors predicts shorter brain metastasis-free survival, supporting diagnostic/prognostic potential."	0.8817
34421997	Frontiers in genetics	2021	"Circ_0084582 Facilitates Cell Growth, Migration, Invasion, and Angiopoiesis in Osteosarcoma via Mediating the miR-485-3p/JAG1 Axis."	hsa_circ_0084582	circ_0084582			Osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ_0084582 is up-regulated in osteosarcoma tissues and cell lines and mainly localizes to the cytoplasm. It promotes osteosarcoma malignant behaviors (proliferation/cell cycle progression, migration, invasion, and angiopoiesis) and tumor growth by sponging miR-485-3p to increase JAG1 expression."	0.8325
34422020	Frontiers in genetics	2021	"Bioinformatics Analysis of circRNA Expression and Construction of ""circRNA-miRNA-mRNA"" Competing Endogenous RNAs Networks in Bipolar Disorder Patients."		Chr7:142060311_142086328			Bipolar disorder 	MONDO:0004985	bipolar disorder	up-regulated	RT-qPCR; RNA-seq	This circRNA was identified as up-regulated in peripheral blood from bipolar disorder patients versus controls by RNA-seq and its differential expression direction was validated by RT-qPCR. It was included as a DE-circRNA for subsequent ceRNA-network construction in the study.	0.3588
34422020	Frontiers in genetics	2021	"Bioinformatics Analysis of circRNA Expression and Construction of ""circRNA-miRNA-mRNA"" Competing Endogenous RNAs Networks in Bipolar Disorder Patients."		Chr13:50027207_50045232__			Bipolar disorder 	MONDO:0004985	bipolar disorder	up-regulated	RT-qPCR; RNA-seq	This circRNA was identified as up-regulated in peripheral blood from bipolar disorder patients versus controls by RNA-seq and its direction was validated by RT-qPCR. It served as one of the DE-circRNAs used for downstream ceRNA-network analyses.	0.3588
34422020	Frontiers in genetics	2021	"Bioinformatics Analysis of circRNA Expression and Construction of ""circRNA-miRNA-mRNA"" Competing Endogenous RNAs Networks in Bipolar Disorder Patients."		Chr6:29945234_30009177_+			Bipolar disorder 	MONDO:0004985	bipolar disorder	up-regulated	RT-qPCR; RNA-seq	This circRNA was found up-regulated in peripheral blood of bipolar disorder patients versus controls and was validated by RT-qPCR consistent with RNA-seq. It was one of the DE-circRNAs used in the study¡¯s ceRNA-network framework.	0.3588
34422020	Frontiers in genetics	2021	"Bioinformatics Analysis of circRNA Expression and Construction of ""circRNA-miRNA-mRNA"" Competing Endogenous RNAs Networks in Bipolar Disorder Patients."		Chr19:54222943_54280299__			Bipolar disorder 	MONDO:0004985	bipolar disorder	down-regulated	RT-qPCR; RNA-seq	This circRNA was identified as down-regulated in peripheral blood from bipolar disorder patients versus controls by RNA-seq and validated by RT-qPCR with consistent direction. It was among the DE-circRNAs used for ceRNA-network construction.	0.3588
34422020	Frontiers in genetics	2021	"Bioinformatics Analysis of circRNA Expression and Construction of ""circRNA-miRNA-mRNA"" Competing Endogenous RNAs Networks in Bipolar Disorder Patients."		Chr5:155854549_155870424_+			Bipolar disorder 	MONDO:0004985	bipolar disorder	down-regulated	RT-qPCR; RNA-seq	"This circRNA was down-regulated in peripheral blood of bipolar disorder patients and the direction was validated by RT-qPCR in clinical samples, consistent with RNA-seq. It was included as a DE-circRNA for downstream ceRNA-network analysis."	0.3588
34422020	Frontiers in genetics	2021	"Bioinformatics Analysis of circRNA Expression and Construction of ""circRNA-miRNA-mRNA"" Competing Endogenous RNAs Networks in Bipolar Disorder Patients."		Chr13:40826506_40855815__			Bipolar disorder 	MONDO:0004985	bipolar disorder	down-regulated	RT-qPCR; RNA-seq	"This circRNA was detected as down-regulated in peripheral blood of bipolar disorder patients compared with controls, and the RNA-seq finding was validated by RT-qPCR with consistent direction. It contributed to the study¡¯s set of DE-circRNAs used for ceRNA-network construction."	0.3588
34422839	Frontiers in cell and developmental biology	2021	Immune Microenvironment Change and Involvement of Circular RNAs in TIL Cells of Recurrent Nasopharyngeal Carcinoma.	hsa_circ_0006935				nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0006935 is up-regulated in NPC tissues and is also highly expressed in immune cells (TIL T cells, including CD3+ cells) from recurrent NPC samples, suggesting a role in the altered immune microenvironment during recurrence after radiotherapy, though the molecular mechanism was not defined."	0.4032
34422839	Frontiers in cell and developmental biology	2021	Immune Microenvironment Change and Involvement of Circular RNAs in TIL Cells of Recurrent Nasopharyngeal Carcinoma.	hsa_circ_0001730				nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0001730 was selected from GEO differential analysis and showed high expression in NPC tissues and in T-cell populations from recurrent NPC samples by qRT-PCR; no specific downstream mechanism was reported.	0.4032
34422839	Frontiers in cell and developmental biology	2021	Immune Microenvironment Change and Involvement of Circular RNAs in TIL Cells of Recurrent Nasopharyngeal Carcinoma.	hsa_circ_0000831				nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0000831 was identified as differentially expressed from GEO data and validated by qRT-PCR as highly expressed in NPC tissues and T-cell fractions from recurrent NPC samples; no mechanism or clinical association was provided.	0.4032
34422839	Frontiers in cell and developmental biology	2021	Immune Microenvironment Change and Involvement of Circular RNAs in TIL Cells of Recurrent Nasopharyngeal Carcinoma.	hsa_circ_0031584				nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; RNA-seq	hsa_ci rc_0031584 (as written in the paper) was among five GEO-selected circRNAs and was validated by qRT-PCR as highly expressed in NPC tissues and T-cell fractions from recurrent NPC samples; no specific mechanism was established.	0.4032
34422839	Frontiers in cell and developmental biology	2021	Immune Microenvironment Change and Involvement of Circular RNAs in TIL Cells of Recurrent Nasopharyngeal Carcinoma.	hsa_circ_0005019				nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0005019 was among five GEO-selected circRNAs and was validated by qRT-PCR as highly expressed in NPC tissues and T-cell fractions from recurrent NPC samples; no downstream targets or pathways were detailed.	0.4032
34422901	Frontiers in molecular biosciences	2021	Circular Ribonucleic Acid circFTO Promotes Angiogenesis and Impairs Blood-Retinal Barrier Via Targeting the miR-128-3p/Thioredoxin Interacting Protein Axis in Diabetic Retinopathy.	hsa_circ_0005941	circ_0005941 	hsa_circ_FTO	FTO	diabetic retinopathy 	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR	circFTO is up-regulated in high-glucose retinal vascular endothelial cells and in diabetic retinopathy mouse retinas. It promotes endothelial cell viability/angiogenesis and blood_retinal barrier breakdown by sponging miR-128-3p to increase TXNIP expression.	0.7537
34423029	BioMed research international	2021	circGLI3 Inhibits Oxidative Stress by Regulating the miR-339-5p/VEGFA Axis in IPEC-J2 Cells.		circGLI3	ssc_circ_GLI3	GLI3	intestinal oxidative stress 	MONDO:0005020	intestinal disorder	unknown	RT-qPCR	"In DQ-induced oxidative stress in porcine IPEC-J2 cells, circGLI3 protects against oxidative damage by acting as a cytoplasmic ceRNA that sponges miR-339-5p and thereby increases VEGFA expression. Functionally, circGLI3 promotes proliferation and S-phase entry, enhances antioxidant capacity, lowers ROS and MDA, and reduces inflammatory factors."	0.5997
34424826	Bioengineered	2021	"Circular RNA circVRK1 suppresses the proliferation, migration and invasion of osteosarcoma cells by regulating zinc finger protein ZNF652 expression via microRNA miR-337-3p."		circVRK1	hsa_circ_VRK1	VRK1	osteosarcoma	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; Northern Blot	"circVRK1 is down-regulated in osteosarcoma and functions as a tumor suppressor by inhibiting proliferation, migration, invasion, and xenograft growth. Mechanistically, it acts as a ceRNA sponging miR-337-3p to increase ZNF652 expression, and low circVRK1 expression is associated with worse prognosis."	0.8654
34429639	International journal of general medicine	2021	The Diagnostic Value of Serum Exosomal Has_circ_0000615 for Breast Cancer Patients.	hsa_circ_0000615	circ_0000615	hsa_circ_ZNF609	ZNF609	breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"has_circ_0000615 is up-regulated in breast cancer patients' plasma and in breast cancer tissues, and is detectable in exosomes. Its elevated level correlates with aggressive clinicopathological features and shows strong diagnostic performance (AUC 0.904) for non-metastatic breast cancer, outperforming conventional serum markers."	0.7154
34429656	Cancer management and research	2021	A Cytoplasm-Enriched circRNA circ-MYBL2 is Downregulated in Non-Small Cell Lung Cancer and Sponges Oncogenic miR-28 to Regulate Cancer Cell Proliferation and Apoptosis.		circ-MYBL2	hsa_circ_MYBL2	MYBL2	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"In NSCLC, circ-MYBL2 is downregulated and mainly localized in the cytoplasm. It directly binds (sponges) miR-28, thereby antagonizing miR-28¡¯s pro-proliferative and anti-apoptotic effects, consistent with a tumor-suppressive role and association of low circ-MYBL2 with poorer survival."	0.7513
34429762	Oncology letters	2021	Circular RNA SLC26A4 regulates the maturation of microRNA-15a in non-small cell lung cancer cells.		circSLC26A4	hsa_circ_SLC26A4	SLC26A4	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circSLC26A4 is up-regulated in NSCLC tissues and its high level is associated with poor overall survival. Functionally, circSLC26A4 promotes NSCLC cell proliferation by suppressing miR-15a maturation (reducing mature miR-15a without affecting its precursor)."	0.5736
34433131	Aging	2021	Mediation of circ_RPPH1 on miR-146b-3p/E2F2 pathway to hinder the growth and metastasis of breast carcinoma cells.	hsa_circ_0000517	circ_RPPH1 	hsa_circ_RPPH1	RPPH1	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circ_RPPH1 is up-regulated in breast cancer and promotes proliferation, migration/invasion, tumor growth and metastasis. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-146b-3p, thereby relieving repression of E2F2 and driving BC progression."	0.8519
34433810	Cell death & disease	2021	hsa_circ_0003222 accelerates stemness and progression of non-small cell lung cancer by sponging miR-527.	hsa_circ_0003222	hsa-circ-0003222 	hsa_circ_LARP4	LARP4	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; ISH	"hsa_circ_0003222 is up-regulated in NSCLC tissues and lung cancer stem-like cells and promotes proliferation, migration/invasion, stemness and cisplatin resistance. Mechanistically, it sponges miR-527 to increase PHF21B and downstream beta-catenin/Wnt signaling, and its inhibition sensitizes tumors to anti-PD-L1 therapy in vivo."	0.8512
34434213	Frontiers in genetics	2021	Construction of a circRNA-Related Prognostic Risk Score Model for Predicting the Immune Landscape of Lung Adenocarcinoma.	hsa_circ_0077607				lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	Microarray	"hsa_circ_0077607 was identified as an upregulated circRNA in LUAD and included in a prognostic ceRNA subnetwork. It is predicted to act as a miRNA sponge (miR-101-3p/miR-218-5p/miR-6720-3p) thereby indirectly affecting expression of HJURP, OIP5 and RRM2 that form a risk-score model linked to immune landscape and therapy sensitivity."	0.1768
34434213	Frontiers in genetics	2021	Construction of a circRNA-Related Prognostic Risk Score Model for Predicting the Immune Landscape of Lung Adenocarcinoma.	hsa_circ_0005699				lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	Microarray	"hsa_circ_0005699 is upregulated in LUAD in GEO-derived circRNA expression profiles and is part of a prognostic ceRNA subnetwork. It is computationally predicted to sponge miR-101-3p/miR-218-5p/miR-6720-3p and thereby influence HJURP, OIP5, and RRM2, which underlie a risk score tied to survival differences, immune infiltration patterns, and predicted drug sensitivity."	0.1768
34434213	Frontiers in genetics	2021	Construction of a circRNA-Related Prognostic Risk Score Model for Predicting the Immune Landscape of Lung Adenocarcinoma.	hsa_circ_0092283				lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	Microarray	"hsa_circ_0092283 is an upregulated circRNA in LUAD and part of a computationally derived prognostic ceRNA subnetwork. It is predicted to sponge miR-101-3p/miR-218-5p/miR-6720-3p to modulate HJURP, OIP5, and RRM2, which contribute to a risk score associated with immune infiltration patterns and predicted sensitivity to chemotherapy/targeted therapy."	0.1768
34434651	PeerJ	2021	Identification of a circRNA-miRNA-mRNA regulatory network for exploring novel therapeutic options for glioma.	hsa_circ_0001156		hsa_circ_PPP1R16B	PPP1R16B	glioma 	MONDO:0021042	glioma	down-regulated	Microarray	"hsa_circ_0001156 is down-regulated in glioma microarray datasets but was not included in the constructed ceRNA network; the paper suggests it may act via non-miRNA-sponge mechanisms (e.g., coding proteins, binding RBPs, or affecting mRNA stability), without experimental validation."	0.1768
34434651	PeerJ	2021	Identification of a circRNA-miRNA-mRNA regulatory network for exploring novel therapeutic options for glioma.	hsa_circ_0030788		hsa_circ_NALCN	NALCN	glioma 	MONDO:0021042	glioma	down-regulated	Microarray	"hsa_circ_0030788 is down-regulated in glioma microarray datasets and is included in the constructed circRNA_miRNA_mRNA ceRNA network. It is predicted (in silico) to bind multiple miRNAs (e.g., miR-5693, miR-6867-5p, miR-607, miR-1248, miR-586, miR-599) and thereby indirectly affect downstream mRNAs; no wet-lab validation is provided."	0.1768
34434651	PeerJ	2021	Identification of a circRNA-miRNA-mRNA regulatory network for exploring novel therapeutic options for glioma.	hsa_circ_0034182		hsa_circ_GABRB3	GABRB3	glioma 	MONDO:0021042	glioma	down-regulated	Microarray	"hsa_circ_0034182 is down-regulated in glioma microarray datasets and is incorporated into the predicted ceRNA network, where it is predicted to bind miR-1200 and thereby influence downstream mRNAs. The evidence is computational without experimental validation."	0.1768
34434651	PeerJ	2021	Identification of a circRNA-miRNA-mRNA regulatory network for exploring novel therapeutic options for glioma.	hsa_circ_0000227		hsa_circ_ZEB1	ZEB1	glioma 	MONDO:0021042	glioma	up-regulated	Microarray	"hsa_circ_0000227 is up-regulated in glioma microarray datasets and is part of the predicted ceRNA network. It is predicted to bind miR-647, miR-1303, and miR-767-3p to indirectly regulate downstream mRNAs; this is based on database predictions without wet-lab validation."	0.1768
34434651	PeerJ	2021	Identification of a circRNA-miRNA-mRNA regulatory network for exploring novel therapeutic options for glioma.	hsa_circ_0018086		hsa_circ_ZEB1	ZEB1	glioma 	MONDO:0021042	glioma	up-regulated	Microarray	"hsa_circ_0018086 is up-regulated in glioma microarray datasets and is included in the predicted ceRNA network. It is predicted to sponge miR-1303, miR-3925-5p, and miR-581 to regulate downstream mRNAs; no experimental validation is reported."	0.1768
34434651	PeerJ	2021	Identification of a circRNA-miRNA-mRNA regulatory network for exploring novel therapeutic options for glioma.	hsa_circ_0000229		hsa_circ_ZEB1	ZEB1	glioma 	MONDO:0021042	glioma	up-regulated	Microarray	hsa_circ_0000229 is up-regulated in glioma microarray datasets and is included in the predicted ceRNA network. It is predicted to bind miR-935 and miR-640 to affect downstream mRNAs; evidence is computational only.	0.1768
34434651	PeerJ	2021	Identification of a circRNA-miRNA-mRNA regulatory network for exploring novel therapeutic options for glioma.	hsa_circ_0036592		hsa_circ_SCAND2	SCAND2	glioma 	MONDO:0021042	glioma	up-regulated	Microarray	hsa_circ_0036592 is up-regulated in glioma microarray datasets and included in the predicted ceRNA network. It is predicted to bind miR-1205 and miR-767-3p and thereby indirectly affect mRNAs; findings are computational and unvalidated experimentally.	0.1768
34434651	PeerJ	2021	Identification of a circRNA-miRNA-mRNA regulatory network for exploring novel therapeutic options for glioma.	hsa_circ_0002765		hsa_circ_ZEB1	ZEB1	glioma 	MONDO:0021042	glioma	up-regulated	Microarray	hsa_circ_0002765 is up-regulated in glioma microarray datasets and included in the predicted ceRNA network. It is predicted to bind miR-587 and miR-767-3p and thereby indirectly regulate mRNAs; no experimental validation is provided.	0.1768
34434890	Frontiers in oncology	2021	Circular RNA FNDC3B Protects Oral Squamous Cell Carcinoma Cells From Ferroptosis and Contributes to the Malignant Progression by Regulating miR-520d-5p/SLC7A11 Axis.		circular RNA FNDC3B 	hsa_circ_FNDC3B	FNDC3B	Oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circFNDC3B is up-regulated in OSCC tissues and promotes malignant progression. Functionally, it suppresses ferroptosis and apoptosis while enhancing proliferation and tumor growth. Mechanistically, circFNDC3B acts as a ceRNA for miR-520d-5p to increase SLC7A11 (and downstream GPX4), thereby reducing ferroptosis-related ROS/iron accumulation."	0.7126
34435133	Open life sciences	2021	Lidocaine has antitumor effect on hepatocellular carcinoma via the circ_DYNC1H1/miR-520a-3p/USP14 axis.	hsa_circ_0033351	circ_DYNC1H1	hsa_circ_DYNC1H1	DYNC1H1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_DYNC1H1 is upregulated in HCC and mainly localized in the cytoplasm. It promotes HCC malignant phenotypes by sponging miR-520a-3p and thereby increasing USP14 expression, and lidocaine suppresses HCC progression partly by downregulating circ_DYNC1H1 to modulate the miR-520a-3p/USP14 axis."	0.8174
34440432	Genes	2021	Systematic Identification of circRNAs in Alzheimer's Disease.		hsa_circ_chr10_128859931_128908618_F	hsa_circ_DOCK1	DOCK1	Alzheimer¡¯s Disease 	MONDO:0004975	Alzheimer disease	dysregulated	RNA-seq	"This study reports a DOCK1-derived circRNA (hsa_circ_chr10_128859931_128908618_F) as differentially abundant in Alzheimer¡¯s disease across public RNA-seq datasets, but its functional role and mechanism were not experimentally characterized."	0.1768
34440432	Genes	2021	Systematic Identification of circRNAs in Alzheimer's Disease.		hsa_circ_chr9_87482157_87482346_F	hsa_circ_NTRK2	NTRK2	Alzheimer¡¯s Disease 	MONDO:0004975	Alzheimer disease	dysregulated	RNA-seq	"This study identifies an NTRK2-derived circRNA (hsa_circ_chr9_87482157_87482346_F) as differentially abundant in Alzheimer¡¯s disease based on public RNA-seq datasets, without downstream functional/mechanistic validation."	0.1768
34440432	Genes	2021	Systematic Identification of circRNAs in Alzheimer's Disease.		hsa_circ_chr3_196802707_196817897_R	hsa_circ_DLG1	DLG1	Alzheimer¡¯s Disease 	MONDO:0004975	Alzheimer disease	unknown	RNA-seq	The DLG1-derived circRNA hsa_circ_chr3_196802707_196817897_R is reported as AD-associated and discussed as being linked to neuronal strength and memory loss; no experimental mechanistic validation was performed beyond RNA-seq/bioinformatic analyses.	0.1768
34446693	Cell death & disease	2021	Circ_0057558 promotes nonalcoholic fatty liver disease by regulating ROCK1/AMPK signaling through targeting miR-206.	hsa_circ_0057558	circ_0057558	hsa_circ_SLC39A10	SLC39A10	nonalcoholic fatty liver disease 	MONDO:0013209	metabolic dysfunction-associated steatotic liver disease	up-regulated	RT-qPCR	"circ_0057558 is up-regulated in NAFLD models and promotes hepatic lipogenesis and triglyceride secretion. Mechanistically, it sponges miR-206 to de-repress ROCK1, leading to reduced AMPK signaling and enhanced lipogenic protein expression."	0.8215
34452628	Journal of experimental & clinical cancer research : CR	2021	Circ-GALNT16 restrains colorectal cancer progression by enhancing the SUMOylation of hnRNPK.	hsa_circ_0102495	circ-GALNT16	hsa_circ_GALNT16	GALNT16	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	"Circ-GALNT16 is downregulated in colorectal cancer and acts as a tumor suppressor. It predominantly localizes to the nucleus, binds hnRNPK (KH3 domain), enhances hnRNPK SUMOylation by blocking SENP2-mediated deSUMOylation, strengthens hnRNPK_p53 transcriptional complex activity, and thereby represses Serpine1 and increases p21, inhibiting proliferation and metastasis and promoting apoptosis. Low circ-GALNT16 is associated with worse clinical features and shorter overall survival."	0.9026
34455918	Bioengineered	2021	A novel circular RNA circPPFIA1 promotes laryngeal squamous cell carcinoma progression through sponging miR-340-3p and regulating ELK1 expression.	hsa_circ_0023326	circPPFIA1 	hsa_circ_PPFIA1	PPFIA1	laryngeal squamous cell carcinoma 	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circPPFIA1 is up-regulated in LSCC tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion) and tumor growth. It functions as a ceRNA by sponging miR-340-3p, thereby relieving repression of ELK1 and driving LSCC progression via the miR-340-3p/ELK1 axis."	0.8195
34456566	Neuropsychiatric disease and treatment	2021	CircRNA circPTK2 Might Suppress Cancer Cell Invasion and Migration of Glioblastoma by Inhibiting miR-23a Maturation.		circPTK2	hsa_circ_PTK2	PTK2	glioblastoma 	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR	"circPTK2 is down-regulated in glioblastoma tissues. Its overexpression suppresses GBM cell invasion and migration by inhibiting maturation of miR-23a, and miR-23a overexpression can reverse these inhibitory effects."	0.5736
34456589	Cancer management and research	2021	CircRNA DUSP16 Knockdown Suppresses Colorectal Cancer Progression by Regulating the miR-432-5p/E2F6 Axis.		CircRNA DUSP16 	hsa_circ_DUSP16	DUSP16	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circDUSP16 is upregulated in colorectal cancer and high expression is associated with poorer overall survival. Functionally, circDUSP16 promotes CRC cell proliferation, migration and invasion and suppresses apoptosis, at least partly by sponging miR-432-5p to increase E2F6 expression; circDUSP16 knockdown inhibits xenograft tumor growth."	0.7548
34457059	Oncology letters	2021	Circ_0074027 binds to EIF4A3 and promotes gastric cancer progression.	hsa_circ_0074027		hsa_circ_PITX1	PITX1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_0074027 is up-regulated in gastric cancer cell lines and promotes GC cell proliferation and motility. Mechanistically, circ_0074027 binds the RNA-binding protein EIF4A3, and EIF4A3 overexpression reverses the inhibitory effects caused by circ_0074027 knockdown."	0.7177
34458003	Molecular therapy. Nucleic acids	2021	ceRNA regulatory network of FIH inhibitor as a radioprotector for gastrointestinal toxicity by activating the HIF-1 pathway.		circRNA_2909 			radiation-induced GI syndrome 	MONDO:0043458	radiation injury	up-regulated	RT-qPCR; RNA-seq	"circRNA_2909 is a novel mouse circRNA upregulated in NOFD-pretreated irradiated intestinal crypts, and is proposed to act as a ceRNA that sponges mmu-miR-92a-1-5p and mmu-miR-148a-3p to promote HIF1A and NOS2 expression, supporting activation of the HIF-1 pathway in a radioprotective context."	0.5922
34458003	Molecular therapy. Nucleic acids	2021	ceRNA regulatory network of FIH inhibitor as a radioprotector for gastrointestinal toxicity by activating the HIF-1 pathway.		circRNA_0323 			radiation-induced GI syndrome 	MONDO:0043458	radiation injury	up-regulated	RT-qPCR; RNA-seq	"circRNA_0323 is a novel mouse circRNA upregulated in NOFD-pretreated irradiated intestinal crypts; it is implicated in a circRNA_miRNA_mRNA ceRNA network (including mmu-miR-92a-1-5p/mmu-miR-148a-3p) that promotes HIF1A and NOS2 expression, supporting HIF-1 pathway activation in radiation-induced GI toxicity."	0.5922
34461805	Bioengineered	2021	Whole-transcriptome analysis of rat cavernosum and identification of circRNA-miRNA-mRNA networks to investigate nerve injury erectile dysfunction pathogenesis.		ciRNA351			cavernous nerve injury erectile dysfunction 	MONDO:0005362	erectile dysfunction	up-regulated	RT-qPCR; RNA-seq	"ciRNA351 is up-regulated in the BCNC (CNI-ED) rat model and was included in the constructed circRNA-miRNA-mRNA ceRNA network. Bioinformatic predictions suggest it may sponge miRNA-let-7a and/or miRNA-129-2-3p to influence Pld1 expression, but this axis was not experimentally validated beyond expression changes."	0.3684
34461805	Bioengineered	2021	Whole-transcriptome analysis of rat cavernosum and identification of circRNA-miRNA-mRNA networks to investigate nerve injury erectile dysfunction pathogenesis.		circRNA2981			cavernous nerve injury erectile dysfunction 	MONDO:0005362	erectile dysfunction	up-regulated	RT-qPCR; RNA-seq	"circRNA2981 is up-regulated in the BCNC (CNI-ED) rat model and is part of the study¡¯s ceRNA network. The authors predict it may sponge miRNA-27b-5p to affect Cxcl10 and mitochondrial/energy metabolism, and it may also sponge miRNA-let-7a/miRNA-129-2-3p to influence Pld1; these interactions were not experimentally validated."	0.3684
34461805	Bioengineered	2021	Whole-transcriptome analysis of rat cavernosum and identification of circRNA-miRNA-mRNA networks to investigate nerve injury erectile dysfunction pathogenesis.		circRNA2982			cavernous nerve injury erectile dysfunction 	MONDO:0005362	erectile dysfunction	up-regulated	RT-qPCR; RNA-seq	"circRNA2982 is up-regulated in the BCNC (CNI-ED) rat model and included in the ceRNA network. The study predicts circRNA2982 may sponge miRNA-let-7a and/or miRNA-129-2-3p to modulate Pld1, without further experimental validation of these interactions."	0.3684
34461805	Bioengineered	2021	Whole-transcriptome analysis of rat cavernosum and identification of circRNA-miRNA-mRNA networks to investigate nerve injury erectile dysfunction pathogenesis.		circRNA2983			cavernous nerve injury erectile dysfunction 	MONDO:0005362	erectile dysfunction	up-regulated	RT-qPCR; RNA-seq	"circRNA2983 is up-regulated in the BCNC (CNI-ED) rat model and included in the ceRNA network. The study predicts circRNA2983 may sponge miRNA-let-7a and/or miRNA-129-2-3p to modulate Pld1, but these interactions were not experimentally validated."	0.3684
34461805	Bioengineered	2021	Whole-transcriptome analysis of rat cavernosum and identification of circRNA-miRNA-mRNA networks to investigate nerve injury erectile dysfunction pathogenesis.		circRNA2984			cavernous nerve injury erectile dysfunction 	MONDO:0005362	erectile dysfunction	up-regulated	RT-qPCR; RNA-seq	"circRNA2984 is up-regulated in the BCNC (CNI-ED) rat model and included in the ceRNA network. It is predicted to sponge miRNA-27b-5p, potentially affecting Cxcl10-associated mitochondrial/energy metabolism dysfunction in CNI-ED, but these interactions are computational and not experimentally verified."	0.3684
34461805	Bioengineered	2021	Whole-transcriptome analysis of rat cavernosum and identification of circRNA-miRNA-mRNA networks to investigate nerve injury erectile dysfunction pathogenesis.		circRNA2986			cavernous nerve injury erectile dysfunction 	MONDO:0005362	erectile dysfunction	up-regulated	RT-qPCR; RNA-seq	"circRNA2986 is up-regulated in the BCNC (CNI-ED) rat model and included in the ceRNA network. The study predicts circRNA2986 may sponge miRNA-let-7a and/or miRNA-129-2-3p to regulate Pld1, but no direct interaction experiments were performed."	0.3684
34461805	Bioengineered	2021	Whole-transcriptome analysis of rat cavernosum and identification of circRNA-miRNA-mRNA networks to investigate nerve injury erectile dysfunction pathogenesis.		circRNA3009			cavernous nerve injury erectile dysfunction 	MONDO:0005362	erectile dysfunction	up-regulated	RT-qPCR; RNA-seq	circRNA3009 is up-regulated in the BCNC (CNI-ED) rat model and included in the ceRNA network. It is predicted to sponge miRNA-27b-5p (affecting Cxcl10 and mitochondrial/energy metabolism dysfunction) and to be involved in Pld1 regulation via miRNA-let-7a/miRNA-129-2-3p; interaction axes were not experimentally validated.	0.3684
34461805	Bioengineered	2021	Whole-transcriptome analysis of rat cavernosum and identification of circRNA-miRNA-mRNA networks to investigate nerve injury erectile dysfunction pathogenesis.		circRNA945			cavernous nerve injury erectile dysfunction 	MONDO:0005362	erectile dysfunction	down-regulated	RT-qPCR; RNA-seq	"circRNA945 is down-regulated in the BCNC (CNI-ED) rat model and included as one of the ten circRNAs in the constructed ceRNA network, but the paper does not provide a specific validated miRNA/mRNA axis or mechanism for this circRNA."	0.3684
34461805	Bioengineered	2021	Whole-transcriptome analysis of rat cavernosum and identification of circRNA-miRNA-mRNA networks to investigate nerve injury erectile dysfunction pathogenesis.		ciRNA109			cavernous nerve injury erectile dysfunction 	MONDO:0005362	erectile dysfunction	down-regulated	RT-qPCR; RNA-seq	"ciRNA109 is down-regulated in the BCNC (CNI-ED) rat model and included among the ten circRNAs used to build the ceRNA network, but no specific downstream miRNA/mRNA target or pathway for ciRNA109 is reported in the text."	0.3684
34461805	Bioengineered	2021	Whole-transcriptome analysis of rat cavernosum and identification of circRNA-miRNA-mRNA networks to investigate nerve injury erectile dysfunction pathogenesis.		ciRNA171			cavernous nerve injury erectile dysfunction 	MONDO:0005362	erectile dysfunction	down-regulated	RT-qPCR; RNA-seq	"ciRNA171 is down-regulated in the BCNC (CNI-ED) rat model and included among the ten circRNAs used to build the ceRNA network, but the paper does not specify its miRNA/mRNA targets or functional pathway."	0.3684
34461805	Bioengineered	2021	Whole-transcriptome analysis of rat cavernosum and identification of circRNA-miRNA-mRNA networks to investigate nerve injury erectile dysfunction pathogenesis.		circRNA1063			cavernous nerve injury erectile dysfunction 	MONDO:0005362	erectile dysfunction	down-regulated	RT-qPCR; RNA-seq	circRNA1063 is down-regulated in the BCNC (CNI-ED) rat model as validated by RT-qPCR. The article does not report a specific ceRNA axis or functional mechanism for circRNA1063.	0.3684
34461926	World journal of surgical oncology	2021	Circ-RNF111 aggravates the malignancy of gastric cancer through miR-876-3p-dependent regulation of KLF12.	hsa_circ_0001982	circ-RNF111 	hsa_circ_RNF111	RNF111	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ-RNF111 is up-regulated in gastric cancer tissues/cells and promotes malignant behaviors (growth, migration/invasion, cell-cycle progression and glycolysis) while suppressing apoptosis. Mechanistically, it functions as a ceRNA by sponging miR-876-3p to increase KLF12 expression, and its knockdown inhibits xenograft tumor growth."	0.7858
34462422	Cell death & disease	2021	Exosomal transfer of tumor-associated macrophage-derived hsa_circ_0001610 reduces radiosensitivity in endometrial cancer.	hsa_circ_0001610	circ_0001610			endometrial cancer 	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR; Microarray	"In endometrial cancer, TAM-derived exosomes deliver hsa_circ_0001610 into tumor cells. hsa_circ_0001610 sponges miR-139-5p to increase CCNB1/cyclin B1, reducing G2/M arrest and weakening radiosensitivity, thereby promoting radioresistance and tumor growth after irradiation."	0.807
34465271	"Cell cycle (Georgetown, Tex.)"	2021	CircLNPEP promotes the progression of ovarian cancer through regulating miR-876-3p/ WNT5A axis.		CircLNPEP 	hsa_circ_LNPEP	LNPEP	ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circLNPEP is up-regulated in ovarian cancer and mainly localized in the cytoplasm. It functions as a ceRNA by sponging miR-876-3p to increase WNT5A, thereby promoting proliferation, migration/invasion, EMT and angiogenesis and inhibiting apoptosis. High circLNPEP expression is associated with advanced clinicopathological features and poorer OS/PFS."	0.8596
34465340	Molecular cancer	2021	Circular RNA circRNF13 inhibits proliferation and metastasis of nasopharyngeal carcinoma via SUMO2.		circRNF13 	hsa_circ_RNF13	RNF13	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	down-regulated	RT-qPCR; ISH; RNA-seq	"circRNF13 is down-regulated in nasopharyngeal carcinoma tissues and cell lines and functions as a tumor suppressor by inhibiting proliferation and metastasis. Mechanistically, it binds the 3¡ä-UTR of SUMO2 mRNA to stabilize it, increasing SUMO2, which promotes GLUT1 SUMOylation/ubiquitination and degradation, suppressing glycolysis and modulating AMPK-mTOR signaling."	0.8531
34468254	Bioengineered	2021	Circ_nuclear factor I X (circNfix) attenuates pressure overload-induced cardiac hypertrophy via regulating miR-145-5p/ATF3 axis.	hsa_circ_0005660		hsa_circ_NFIX	NFIX	cardiac hypertrophy 	MONDO:0001302	hypertensive heart disease	down-regulated	RT-qPCR	"circNfix (circBase: hsa_circ_0005660, from NFIX exon 2) is down-regulated in Ang II-treated cardiomyocytes and in TAC-induced hypertrophic mouse hearts. Its overexpression attenuates cardiac hypertrophy and cardiomyocyte apoptosis mainly by sponging miR-145-5p to de-repress ATF3 (circNfix/miR-145-5p/ATF3 axis)."	0.8351
34468254	Bioengineered	2021	Circ_nuclear factor I X (circNfix) attenuates pressure overload-induced cardiac hypertrophy via regulating miR-145-5p/ATF3 axis.			mmu_circ_NFIX	Nfix	cardiac hypertrophy 	MONDO:0001302	hypertensive heart disease	down-regulated	RT-qPCR	"circNfix (circBase: hsa_circ_0005660, from NFIX exon 2) is down-regulated in Ang II-treated cardiomyocytes and in TAC-induced hypertrophic mouse hearts. Its overexpression attenuates cardiac hypertrophy and cardiomyocyte apoptosis mainly by sponging miR-145-5p to de-repress ATF3 (circNfix/miR-145-5p/ATF3 axis)."	0.8351
34471635	BioMed research international	2021	A Potential ceRNA Network for Neurological Damage in Preterm Infants.	hsa_circ_0008439				neurological damage 	MONDO:0005071	nervous system disorder	down-regulated	Microarray	"This study identified hsa_circ_0008439 as a differentially expressed (downregulated) circRNA in preterm infants with neurological injury/PWMD. Bioinformatics network construction suggested a ceRNA axis hsa_circ_0008439_hsa-mir-3665_STAT3_MMP3 potentially contributing to neurodevelopmental damage, with links to oxidative phosphorylation changes via suppressed STAT3."	0.1768
34471635	BioMed research international	2021	A Potential ceRNA Network for Neurological Damage in Preterm Infants.	hsa_circ_0004976	circ_0004976			neurological injury 	MONDO:0005071	nervous system disorder	unknown	Microarray	"circ_0004976 was identified computationally as one of the circRNAs linked to miR-3665 in a predicted regulatory axis (circ_0004976_miR-3665_ASXL2) potentially relevant to neurological injury in preterm infants, but without experimental validation or reported direction of dysregulation in the text provided."	0.1768
34479497	BMC anesthesiology	2021	Sevoflurane blocks glioma malignant development by upregulating circRELN through circRELN-mediated miR-1290/RORA axis.	hsa_circ_0081769	circ_0081769 	hsa_circ_RELN	RELN	glioma	MONDO:0021042	glioma	down-regulated	RT-qPCR; RNA-seq	"circRELN is down-regulated in glioma tissues and cell lines, and sevoflurane increases its expression. circRELN suppresses glioma malignant behaviors and tumor growth by sponging miR-1290 and thereby de-repressing RORA (circRELN/miR-1290/RORA axis)."	0.8279
34479583	World journal of surgical oncology	2021	Importance of Circ0009910 in colorectal cancer pathogenesis as a possible regulator of miR-145 and PEAK1.	hsa_circ_0009910 	Circ0009910 	hsa_circ_MFN2	MFN2	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circ0009910 is upregulated in colorectal cancer tissues and is proposed to act as a ceRNA that sponges miR-145-5p, thereby associating with increased PEAK1 expression. Its expression shows diagnostic potential for CRC based on ROC analysis."	0.6556
34479589	World journal of surgical oncology	2021	Circ_0029803 serves as the sponge of miR-216b-5p to promote the progression of colorectal cancer by regulating SKIL expression.	hsa_circ_0029803	Circular RNA 0029803			colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0029803 is up-regulated in colorectal cancer and acts as an oncogenic circRNA. It mainly localizes to the cytoplasm and promotes CRC malignant phenotypes (proliferation, migration/invasion, EMT, glycolysis, and tumor growth) by sponging miR-216b-5p to increase SKIL expression, and high expression predicts worse overall survival."	0.8153
34482767	Technology in cancer research & treatment	2021	"Negative Correlation Between Circular RNA SMARC5 and MicroRNA 432, and Their Clinical Implications in Bladder Cancer Patients."		circular RNA SMARCA5	hsa_circ_SMARCA5	SMARCA5	bladder cancer	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"In this retrospective cohort of bladder cancer patients, circ-SMARCA5 is up-regulated in tumor tissues and negatively correlated with miR-432. High circ-SMARCA5 expression associates with more aggressive clinicopathologic features and independently predicts shorter DFS and OS."	0.6023
34483137	Aging	2021	Hsa-circ-0007292 promotes the osteogenic differentiation of posterior longitudinal ligament cells via regulating SATB2 by sponging miR-508-3p.	hsa_circ_0007292	hsa-circ-0007292 	hsa_circ_ATP5C1	ATP5C1	Ossification of the posterior longitudinal ligament 	MONDO:0011230	ossification of the posterior longitudinal ligament of the spine	up-regulated	RT-qPCR; Microarray	"hsa_circ_0007292 is up-regulated in OPLL PLL tissues/cells and promotes osteogenic differentiation. It predominantly localizes in the cytoplasm and functions as a ceRNA by sponging miR-508-3p, thereby relieving repression of SATB2 and enhancing osteogenesis-related marker expression."	0.7495
34483139	Aging	2021	Knockdown of hsa_circ_0091994 constrains gastric cancer progression by suppressing the miR-324-5p/HMGA1 axis.	hsa_circ_0091994	cicrRNA_105040 	hsa_circ_FLNA	FLNA	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0091994 is up-regulated in gastric cancer tissues and promotes malignant phenotypes. Its knockdown suppresses proliferation/viability, reduces wound healing ability and EMT markers, and increases apoptosis, and it inhibits tumor growth in a cell line-derived xenograft model by repressing the miR-324-5p/HMGA1 axis (ceRNA regulation)."	0.7094
34483886	Frontiers in aging neuroscience	2021	Microarray Analysis Identifies Key Differentially Expressed Circular RNAs in Aged Mice With Postoperative Cognitive Dysfunction.		circRNA_28795 			postoperative cognitive dysfunction 	MONDO:0002039	cognitive disorder	up-regulated	RT-qPCR; Microarray	circRNA_28795 is up-regulated in hippocampal tissue of aged mice with POCD and was validated by RT-qPCR. The study predicts that it may participate in POCD through a circRNA-miRNA-mRNA ceRNA network.	0.4997
34483886	Frontiers in aging neuroscience	2021	Microarray Analysis Identifies Key Differentially Expressed Circular RNAs in Aged Mice With Postoperative Cognitive Dysfunction.		mmu_circRNA_44122 			postoperative cognitive dysfunction 	MONDO:0002039	cognitive disorder	up-regulated	RT-qPCR; Microarray	circRNA_44122 is up-regulated in POCD hippocampal tissue (validated by RT-qPCR). Bioinformatics analysis suggests it may participate in POCD via a ceRNA network and potentially regulate Egfr.	0.4997
34483886	Frontiers in aging neuroscience	2021	Microarray Analysis Identifies Key Differentially Expressed Circular RNAs in Aged Mice With Postoperative Cognitive Dysfunction.		mmu_circRNA_22058 			postoperative cognitive dysfunction 	MONDO:0002039	cognitive disorder	up-regulated	RT-qPCR; Microarray	circRNA_22058 is up-regulated in POCD hippocampal tissue (validated by RT-qPCR). The study predicts a ceRNA network involving circRNA_22058 and suggests potential regulation of Egfr in POCD.	0.4997
34483886	Frontiers in aging neuroscience	2021	Microarray Analysis Identifies Key Differentially Expressed Circular RNAs in Aged Mice With Postoperative Cognitive Dysfunction.		mmu_circRNA_44559 			postoperative cognitive dysfunction 	MONDO:0002039	cognitive disorder	down-regulated	RT-qPCR; Microarray	circRNA_44559 is down-regulated in POCD hippocampal tissue and was validated by RT-qPCR. The study predicts it may be involved in POCD through a circRNA-miRNA-mRNA ceRNA network.	0.4997
34483886	Frontiers in aging neuroscience	2021	Microarray Analysis Identifies Key Differentially Expressed Circular RNAs in Aged Mice With Postoperative Cognitive Dysfunction.		mmu_circRNA_22673 			postoperative cognitive dysfunction 	MONDO:0002039	cognitive disorder	down-regulated	RT-qPCR; Microarray	"circRNA_22673 is down-regulated in POCD hippocampal tissue and was validated by RT-qPCR. Bioinformatics suggests a ceRNA network and potential downstream modulation of Prkacb, which is linked to MAPK-related processes in the discussion."	0.4997
34485151	Frontiers in oncology	2021	"circCDYL2, Overexpressed in Highly Migratory Colorectal Cancer Cells, Promotes Migration by Binding to Ezrin."	hsa_circ_0004087	circCDYL2	hsa_circ_CDYL2	CDYL2	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"circCDYL2 (hsa_circ_0004087), derived from CDYL2, is up-regulated in colorectal cancer tissues and CRC cell lines. It promotes CRC cell migration by binding Ezrin, increasing Ezrin protein levels, and activating AKT phosphorylation, supporting a pro-metastatic role."	0.8173
34485272	Frontiers in cell and developmental biology	2021	CircRNF111 Protects Against Insulin Resistance and Lipid Deposition via Regulating miR-143-3p/IGF2R Axis in Metabolic Syndrome.	hsa_circ_0001982	circRNF111	hsa_circ_RNF111	RNF111	Metabolic Syndrome 	MONDO:0000816	abdominal obesity-metabolic syndrome	down-regulated	RT-qPCR; RNA-seq	"CircRNF111 is down-regulated in MetS serum/urine and acts protectively against insulin resistance and lipid deposition. It mainly functions as a cytoplasmic ceRNA that sponges miR-143-3p, relieving repression of IGF2R and supporting insulin signaling (Akt phosphorylation), improving glucose uptake and reducing triglyceride accumulation; this was supported by in vitro hADSC assays and HFD-induced obese mouse experiments."	0.8476
34485273	Frontiers in cell and developmental biology	2021	CircCDYL Acts as a Tumor Suppressor in Wilms' Tumor by Targeting miR-145-5p.	hsa_circ_0008285	circCDYL 	hsa_circ_CDYL	CDYL	Wilms¡¯ tumor 	MONDO:0006058	Wilms tumor	down-regulated	RT-qPCR; RNA-seq	"circCDYL is down-regulated in Wilms¡¯ tumor and functions as a tumor suppressor. It sponges miR-145-5p to relieve repression of TJP1, thereby inhibiting WT cell proliferation, migration, and invasion, with validation in vitro and in a cell line-derived xenograft model."	0.843
34486489	Bioengineered	2021	"Exploration of differentially-expressed exosomal mRNAs, lncRNAs and circRNAs from serum samples of gallbladder cancer and xantho-granulomatous cholecystitis patients."		circDNAJC6	hsa_circ_DNAJC6	DNAJC6	gallbladder cancer 	MONDO:0005411	gallbladder cancer	dysregulated	RNA-seq	"circDNAJC6 is significantly differentially expressed in plasma-derived exosomes from gallbladder cancer patients compared with xantho-granulomatous cholecystitis controls. It was included among key exosomal DE genes highlighted by RNA-seq and downstream bioinformatic/ceRNA-network analyses, but no specific functional mechanism was experimentally validated for this circRNA."	0.1768
34486489	Bioengineered	2021	"Exploration of differentially-expressed exosomal mRNAs, lncRNAs and circRNAs from serum samples of gallbladder cancer and xantho-granulomatous cholecystitis patients."		circPIK3C3	hsa_circ_PIK3C3	PIK3C3	gallbladder cancer 	MONDO:0005411	gallbladder cancer	dysregulated	RNA-seq	"circPIK3C3 is significantly differentially expressed in plasma-derived exosomes from gallbladder cancer patients compared with xantho-granulomatous cholecystitis controls. It was highlighted as a widely expressed DE exosomal circRNA in the RNA-seq dataset, with only computational ceRNA/miRNA-target analyses reported and no direct experimental functional validation."	0.1768
34486534	Anti-cancer drugs	2022	Arsenic sulfide inhibits the progression of gastric cancer through regulating the circRNA_ASAP2/Wnt/beta-catenin pathway.	hsa_circ_0006089	circRNA_ASAP2	hsa_circ_ASAP2	ASAP2	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"circRNA_ASAP2 is downregulated in gastric cancer cells vs. normal gastric epithelial cells. Functionally, circRNA_ASAP2 promotes GC cell proliferation, migration and invasion and inhibits apoptosis, at least partly by activating Wnt/beta-catenin signaling; As4S4 suppresses GC progression by downregulating circRNA_ASAP2 and inhibiting Wnt/beta-catenin activity."	0.47
34489401	Cell death discovery	2021	Circbeta-catenin promotes tumor growth and Warburg effect of gallbladder cancer by regulating STMN1 expression.		circbeta-catenin	hsa_circ_CTNNB1	beta-catenin	gallbladder cancer 	MONDO:0005411	gallbladder cancer	up-regulated	RT-qPCR	"circbeta-catenin is up-regulated in gallbladder cancer and mainly localizes to the cytoplasm. It promotes proliferation, cell-cycle progression, tumor growth, and the Warburg effect by sponging miR-223 to increase STMN1 expression, and high circbeta-catenin is associated with worse overall survival."	0.8508
34493213	Biological procedures online	2021	Circ-ABCB10 knockdown inhibits the malignant progression of cervical cancer through microRNA-128-3p/ZEB1 axis.		circ-ABCB10	hsa_circ_ABCB10	ABCB10	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ-ABCB10 is up-regulated in cervical cancer tissues/cell lines and promotes malignant phenotypes (proliferation, invasion, EMT) while suppressing apoptosis. Mechanistically, it sponges miR-128-3p to increase ZEB1 expression, thereby enhancing tumor growth in xenograft models."	0.7548
34496888	Molecular cancer	2021	CircMYH9 drives colorectal cancer growth by regulating serine metabolism and redox homeostasis in a p53-dependent manner.	hsa_circ_0092283	circMYH9	hsa_circ_MYH9	MYH9	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; Microarray	"circMYH9 (hsa_circ_0092283), an intron-derived circRNA from MYH9, is up-regulated in colorectal cancer and mainly localized in the nucleus. It promotes CRC growth by reducing p53 via hnRNPA2B1-associated destabilization of p53 pre-mRNA, which increases PHGDH-driven serine/glycine metabolism and supports redox homeostasis (lower ROS, higher NAD+/NADH and GSH recycling). High circMYH9 levels predict worse RFS/OS in CRC patients, and it enhances tumorigenesis in vivo including AOM/DSS models and xenografts."	0.904
34497684	Oxidative medicine and cellular longevity	2021	Prognostic Nomogram Based on Circular RNA-Associated Competing Endogenous RNA Network for Patients with Lung Adenocarcinoma.	hsa_circ_0002191				lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	dysregulated	Microarray	"This circRNA was identified as a differentially expressed circRNA in LUAD and included in a constructed circRNA_miRNA_mRNA ceRNA network. It was proposed to interact with has-miR-144-3p and thereby potentially regulate CEP55, KIF14, and PRR11, influencing LUAD progression and prognosis."	0.1768
34497684	Oxidative medicine and cellular longevity	2021	Prognostic Nomogram Based on Circular RNA-Associated Competing Endogenous RNA Network for Patients with Lung Adenocarcinoma.	hsa_circ_0002727				lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	dysregulated	Microarray	"This circRNA was identified as a differentially expressed circRNA in LUAD and included in a constructed circRNA_miRNA_mRNA ceRNA network. It was proposed to interact with has-miR-144-3p and thereby potentially regulate CEP55, KIF14, and PRR11, influencing LUAD progression and prognosis."	0.1768
34497684	Oxidative medicine and cellular longevity	2021	Prognostic Nomogram Based on Circular RNA-Associated Competing Endogenous RNA Network for Patients with Lung Adenocarcinoma.	hsa_circ_0049271				lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	dysregulated	Microarray	"This circRNA was identified as a differentially expressed circRNA in LUAD and incorporated into the study¡¯s circRNA-associated ceRNA network, but no specific downstream miRNA/mRNA axis was detailed for it."	0.1768
34497684	Oxidative medicine and cellular longevity	2021	Prognostic Nomogram Based on Circular RNA-Associated Competing Endogenous RNA Network for Patients with Lung Adenocarcinoma.	hsa_circ_0050395				lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	dysregulated	Microarray	"This circRNA was identified as a differentially expressed circRNA in LUAD and incorporated into the study¡¯s circRNA-associated ceRNA network, but no specific downstream miRNA/mRNA axis was detailed for it."	0.1768
34497684	Oxidative medicine and cellular longevity	2021	Prognostic Nomogram Based on Circular RNA-Associated Competing Endogenous RNA Network for Patients with Lung Adenocarcinoma.	hsa_circ_0001974				lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	dysregulated	Microarray	"This circRNA was identified as a differentially expressed circRNA in LUAD and incorporated into the study¡¯s circRNA-associated ceRNA network, but no specific downstream miRNA/mRNA axis was detailed for it."	0.1768
34497684	Oxidative medicine and cellular longevity	2021	Prognostic Nomogram Based on Circular RNA-Associated Competing Endogenous RNA Network for Patients with Lung Adenocarcinoma.	hsa_circ_0004006				lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	dysregulated	Microarray	"This circRNA was identified as a differentially expressed circRNA in LUAD and incorporated into the study¡¯s circRNA-associated ceRNA network, but no specific downstream miRNA/mRNA axis was detailed for it."	0.1768
34497684	Oxidative medicine and cellular longevity	2021	Prognostic Nomogram Based on Circular RNA-Associated Competing Endogenous RNA Network for Patients with Lung Adenocarcinoma.	hsa_circ_0000641				lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	dysregulated	Microarray	"This circRNA was identified as a differentially expressed circRNA in LUAD and incorporated into the study¡¯s circRNA-associated ceRNA network, but no specific downstream miRNA/mRNA axis was detailed for it."	0.1768
34497684	Oxidative medicine and cellular longevity	2021	Prognostic Nomogram Based on Circular RNA-Associated Competing Endogenous RNA Network for Patients with Lung Adenocarcinoma.	hsa_circ_0079929	hsa_circRNA_0079929			lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	dysregulated	Microarray	"This circRNA was identified as a differentially expressed circRNA in LUAD and included in the constructed ceRNA network; however, this paper did not provide a specific LUAD mechanism for it beyond network inclusion."	0.1768
34497684	Oxidative medicine and cellular longevity	2021	Prognostic Nomogram Based on Circular RNA-Associated Competing Endogenous RNA Network for Patients with Lung Adenocarcinoma.	hsa_circ_0007788				lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	dysregulated	Microarray	"This circRNA was identified as a differentially expressed circRNA in LUAD and incorporated into the study¡¯s circRNA-associated ceRNA network, but no specific downstream miRNA/mRNA axis was detailed for it."	0.1768
34497684	Oxidative medicine and cellular longevity	2021	Prognostic Nomogram Based on Circular RNA-Associated Competing Endogenous RNA Network for Patients with Lung Adenocarcinoma.	hsa_circ_0001936				lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	dysregulated	Microarray	"hsa_circ_0001936 was identified as a LUAD-associated differentially expressed circRNA in the ceRNA network. The study suggests it interacts with has-miR-142-5p and may regulate target genes (CAV2/FGD5/S1PR1) linked to GTPase activity, potentially contributing to LUAD progression."	0.1768
34497684	Oxidative medicine and cellular longevity	2021	Prognostic Nomogram Based on Circular RNA-Associated Competing Endogenous RNA Network for Patients with Lung Adenocarcinoma.	hsa_circ_0015278	hsa_circRNA_0015278			lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	dysregulated	Microarray	"This circRNA was identified as a differentially expressed circRNA in LUAD and included in the constructed ceRNA network, but the paper did not report a LUAD-specific downstream axis or functional validation for it."	0.1768
34498720	Molecular medicine reports	2021	circFLNA promotes glioblastoma proliferation and invasion by negatively regulating miR_199_3p expression.	hsa_circ_0092012	circFLNA 	hsa_circ_FLNA	FLNA	glioblastoma 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; Microarray	"circFLNA (hsa_circ_0092012) is up-regulated in glioblastoma tissues and GBM cell lines and promotes GBM cell proliferation and invasion. Mechanistically, circFLNA interacts with and suppresses miR-199-3p, consistent with a ceRNA/miRNA-sponge model, and high circFLNA expression is associated with worse overall survival."	0.7916
34498800	"Cancer communications (London, England)"	2021	"A novel intronic circular RNA, circGNG7, inhibits head and neck squamous cell carcinoma progression by blocking the phosphorylation of heat shock protein 27 at Ser78 and Ser82."		circGNG7	hsa_circ_GNG7	GNG7	head and neck squamous cell carcinoma 	MONDO:0010150	head and neck squamous cell carcinoma	down-regulated	RT-qPCR; ISH; Microarray	"circGNG7 is down-regulated in HNSCC and acts as a tumor suppressor. It is promoted by SMAD4 and inhibits HNSCC progression by binding HSP27 at Ser78/Ser82 to block HSP27 phosphorylation, thereby reducing HSP27-driven JNK/P38 MAPK signaling; low circGNG7 is associated with worse patient survival."	0.8904
34499009	Bioengineered	2021	The circular RNA circ0005654 interacts with specificity protein 1 via microRNA-363 sequestration to promote gastric cancer progression.	hsa_circ_0005654	circ0005654	hsa_circ_PRDM2	PRDM2	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ0005654 is up-regulated in gastric cancer tissues and cell lines and is mainly localized in the cytoplasm. It promotes malignant phenotypes (proliferation, migration/invasion, tumor growth and metastasis) by sponging miR-363 to increase sp1, which activates myc transcription and potentiates Wnt/beta-catenin signaling. High circ0005654 is associated with poor prognosis and has diagnostic value in GC."	0.7976
34502114	International journal of molecular sciences	2021	Gender-Dependent Deregulation of Linear and Circular RNA Variants of HOMER1 in the Entorhinal Cortex of Alzheimer's Disease.	hsa_circ_0006916	circHOMER1 	hsa_circ_HOMER1	HOMER1	Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR	"hsa_circ_0006916 (a HOMER1-derived circRNA) is down-regulated in the entorhinal cortex of female Alzheimer¡¯s disease cases versus controls. The study reports association-level links to AD pathology and discusses potential biomarker relevance, without establishing a specific mechanistic axis."	0.5129
34502114	International journal of molecular sciences	2021	Gender-Dependent Deregulation of Linear and Circular RNA Variants of HOMER1 in the Entorhinal Cortex of Alzheimer's Disease.	hsa_circ_0073127	circHOMER1 	hsa_circ_HOMER1	HOMER1	Alzheimer¡¯s disease 	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR	"hsa_circ_0073127 is a HOMER1-derived circRNA that is down-regulated in the entorhinal cortex of female AD patients compared with female controls. Its expression shows a negative correlation with Abeta deposit burden, and the paper highlights it as a novel, gender-specific circRNA associated with AD pathology without defining a downstream mechanistic axis."	0.5466
34504560	Experimental and therapeutic medicine	2021	Suppression of circ_0008932 inhibits tumor growth and metastasis in osteosarcoma by targeting miR-145-5p.	hsa_circ_0008932	circ_0008932			osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ_0008932 is upregulated in osteosarcoma tissues and cell lines and is associated with metastasis and poor overall survival. Functionally, circ_0008932 promotes osteosarcoma cell proliferation, migration and invasion while inhibiting apoptosis, at least partly by directly binding and repressing miR-145-5p."	0.7078
34504600	Experimental and therapeutic medicine	2021	"circASS1 overexpression inhibits the proliferation, invasion and migration of colorectal cancer cells by regulating the miR-1269a/VASH1 axis."		circASS1 	hsa_circ_ASS1		colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"circASS1 is down-regulated in colorectal cancer tissues and CRC cell lines. circASS1 overexpression suppresses CRC cell proliferation, migration and invasion and promotes apoptosis by sponging miR-1269a and relieving repression of VASH1 (circASS1/miR-1269a/VASH1 axis)."	0.6285
34504842	Frontiers in cell and developmental biology	2021	CircITGA7 Suppresses Gastric Cancer Progression Through miR-1471/MTDH Axis.		circITGA7 	hsa_circ_ITGA7	ITGA7	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; RNA-seq	"circITGA7 is downregulated in gastric cancer tissues/cell lines and functions as a tumor suppressor by inhibiting proliferation and metastatic behaviors. Mechanistically, it sponges miR-1471 to regulate the downstream target MTDH, forming a circITGA7/miR-1471/MTDH axis that modulates GC progression."	0.6676
34507559	Journal of translational medicine	2021	Hsa_circ_0001361 facilitates the progress of lung adenocarcinoma cells via targeting miR-525-5p/VMA21 axis.	hsa_circ_0001361	Circ_0001361	hsa_circ_FNDC3B	FNDC3B	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"circ_0001361 is up-regulated in LUAD tissues and cell lines and mainly localizes to the cytoplasm. It promotes LUAD proliferation and metastatic behaviors by sponging miR-525-5p, thereby increasing VMA21 expression, and its silencing suppresses xenograft tumor growth."	0.7523
34507595	Journal of ovarian research	2021	Hsa_circ_0004712 downregulation attenuates ovarian cancer malignant development by targeting the miR-331-3p/FZD4 pathway.	hsa_circ_0004712				ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"hsa_circ_0004712 is up-regulated in ovarian cancer tissues and cell lines and functions as an oncogenic circRNA. Its knockdown suppresses proliferation/colony formation, invasion and migration and increases apoptosis, and it inhibits tumor growth in vivo. Mechanistically, it sponges miR-331-3p to relieve repression of FZD4, forming a hsa_circ_0004712/miR-331-3p/FZD4 axis associated with poor survival."	0.7554
34511434	Aging	2021	Up-regulation of circARF3 reduces blood-brain barrier damage in rat subarachnoid hemorrhage model via miR-31-5p/MyD88/NF-kappaB axis.		circARF3	rno_circ_ARF3	ARF3	subarachnoid hemorrhage 	MONDO:0005099	subarachnoid hemorrhage	down-regulated	RT-qPCR	"circARF3 is down-regulated in SAH patient plasma/CSF and in SAH rat brain tissue. circARF3 protects against SAH-associated BBB disruption and neuroinflammation by sponging miR-31-5p and suppressing the MyD88/NF-kappaB inflammatory pathway, improving neurological outcomes."	0.7375
34511934	OncoTargets and therapy	2021	A Preliminary Study on the Pathogenesis of Colorectal Cancer by Constructing a Hsa-circRNA-0067835-miRNA-mRNA Regulatory Network.		hsa-circRNA-0067835 	hsa_circ_IFT80	IFT80	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"In colorectal cancer, circIFT80 (hsa-circRNA-0067835) is up-regulated and promotes malignant phenotypes (proliferation, migration, invasion) while inhibiting apoptosis. Mechanistically, it sponges hsa-miR-370-3p to upregulate WNT7B and is positively associated with COL6A6, RCBTB1 and SLC1A5 expression."	0.6536
34511976	Journal of inflammation research	2021	Identification and Integrated Analysis of circRNA and miRNA of Radiation-Induced Lung Injury in a Mouse Model.		circRNA5229			radiation-induced lung injury 	MONDO:0043458	radiation injury	up-regulated	RT-qPCR; RNA-seq	circRNA5229 is significantly up-regulated in irradiated mouse lung tissue in an acute RILI model. It was included as an up-regulated circRNA in a predicted circRNA_miRNA_mRNA (ceRNA) network associated with Th1 and Th2 differentiation pathways.	0.3684
34511976	Journal of inflammation research	2021	Identification and Integrated Analysis of circRNA and miRNA of Radiation-Induced Lung Injury in a Mouse Model.		circRNA544			radiation-induced lung injury 	MONDO:0043458	radiation injury	up-regulated	RT-qPCR; RNA-seq	circRNA544 is significantly up-regulated in irradiated mouse lung tissue in an acute RILI model. The study implicates a ceRNA axis circRNA544/miR-188-3p/Il2ra linked to Th1 and Th2 differentiation-related immune regulation.	0.3684
34511976	Journal of inflammation research	2021	Identification and Integrated Analysis of circRNA and miRNA of Radiation-Induced Lung Injury in a Mouse Model.		circRNA3340			radiation-induced lung injury 	MONDO:0043458	radiation injury	up-regulated	RT-qPCR; RNA-seq	circRNA3340 is significantly up-regulated in irradiated mouse lung tissue in an acute RILI model. The study suggests a ceRNA axis circRNA3340/miR-146a-5p/CD4 associated with Th1 and Th2 differentiation-related immune regulation.	0.3684
34512021	Cancer management and research	2021	circTADA2A Retards the Progression of Colorectal Cancer via Regulating miR-1229/BCL2L10 Signal Axis.		circTADA2A 	hsa_circ_TADA2A	TADA2A	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	circTADA2A is down-regulated in colorectal cancer and acts as a tumor suppressor by inhibiting proliferation and migration. It functions as a ceRNA that sponges miR-1229 to relieve miR-1229-mediated suppression of BCL2L10.	0.8111
34512755	Journal of oncology	2021	Circular RNA hsa_circ_0006117 Facilitates Pancreatic Cancer Progression by Regulating the miR-96-5p/KRAS/MAPK Signaling Pathway.	hsa_circ_0006117		hsa_circ_PTPRA	PTPRA	pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; Microarray	"hsa_circ_0006117 is up-regulated in pancreatic cancer tissues and cell lines and functions as an oncogenic circRNA. It mainly localizes in the cytoplasm and promotes proliferation, migration, and invasion by sponging miR-96-5p to upregulate KRAS and activate the MAPK (MEK/ERK) signaling pathway."	0.8174
34513299	Molecular therapy. Nucleic acids	2021	hsa_circ_0068631 promotes breast cancer progression through c-Myc by binding to EIF4A3.	hsa_circ_0068631		hsa_circ_TFRC	TFRC	Breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"hsa_circ_0068631 is upregulated in breast cancer tissues and cell lines and promotes proliferation, migration, and tumor growth. Mechanistically, it binds and recruits the RBP EIF4A3 to c-Myc mRNA, increasing c-Myc mRNA stability and elevating c-Myc protein expression, thereby driving breast cancer progression."	0.8588
34514002	Journal of immunology research	2021	Circular RNA FOXP1 Induced by ZNF263 Upregulates U2AF2 Expression to Accelerate Renal Cell Carcinoma Tumorigenesis and Warburg Effect through Sponging miR-423-5p.			hsa_circ_FOXP1	FOXP1	renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR	"circFOXP1 is up-regulated in RCC tissues and cell lines and acts pro-tumorigenically by promoting proliferation, migration, invasion, and the Warburg effect. Mechanistically, it functions as a ceRNA to sponge miR-423-5p, thereby increasing U2AF2, and its expression is induced by ZNF263."	0.8246
34515615	Bioengineered	2021	Circular RNA hsa_circ_0075542 acts as a sponge for microRNA-1197 to suppress malignant characteristics and promote apoptosis in prostate cancer cells.	hsa_circ_0075542	ov-circ_0075542 			prostate cancer	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR	hsa_circ_0075542 is down-regulated in prostate cancer tissues and acts as a tumor suppressor in LNCaP and PC3 cells. It promotes apoptosis and inhibits proliferation/migration/invasion by sponging miR-1197 and relieving miR-1197-mediated repression of HOXC11.	0.8111
34516314	Bioengineered	2021	Circular RNA circ_0089153 acts as a competing endogenous RNA to regulate colorectal cancer development by the miR-198/SUMO-specific peptidase 1 (SENP1) axis.	hsa_circ_0089153	circ_0089153	hsa_circ_NUP214	NUP214	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0089153 is up-regulated in colorectal cancer and promotes malignant phenotypes (proliferation, stemness/sphere formation, angiogenesis) while suppressing apoptosis, and it enhances tumor growth in vivo. Mechanistically, it functions as a ceRNA that sponges miR-198 to de-repress SENP1, forming a circ_0089153/miR-198/SENP1 regulatory axis."	0.8171
34516341	Bioengineered	2021	Identification of hsa_circ_0002024 as a prognostic competing endogenous RNA (ceRNA) through the hsa_miR_129-5p/Anti-Silencing Function 1B Histone Chaperone (ASF1B) axis in renal cell carcinoma.	hsa_circ_0002024				renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	up-regulated	RNA-seq	"This study identified hsa_circ_0002024 as an upregulated circRNA in RCC and a prognostic ceRNA candidate. It was proposed to sponge hsa_miR_129-5p, thereby relieving repression of ASF1B and associating with worse overall survival."	0.348
34517790	Bioengineered	2021	Circular RNA SMEK1 promotes neuropathic pain in rats through targeting microRNA-216a-5p to mediate Thioredoxin Interacting Protein (TXNIP) expression.		circSMEK1 	rno_circ_SMEK1	SMEK1	neuropathic pain 	MONDO:0021667	neuralgia	up-regulated	RT-qPCR	"In CCI-induced neuropathic pain rats and LPS-stimulated microglia, circSMEK1 is up-regulated and aggravates pain behaviors and spinal cord inflammation. Mechanistically, circSMEK1 sponges miR-216a-5p to increase TXNIP expression, promoting microglia activation and M1 polarization; rescue experiments support the circSMEK1/miR-216a-5p/TXNIP axis."	0.6898
34519258	Bioengineered	2021	Circular RNA Circ_0000677 promotes cell proliferation by regulating microRNA-106b-5p/CCND1 in non-small cell lung cancer.	hsa_circ_0000677	circ_0000677 			non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; ISH	"circ_0000677 is up-regulated in NSCLC tissues and predicts worse overall survival. It promotes NSCLC proliferation and in vivo tumor growth by sponging miR-106b-5p and de-repressing CCND1 (cyclin D1), forming a circ_0000677/miR-106b/CCND1 axis."	0.7357
34519627	Bioengineered	2021	"A circular RNA, circUSP36, accelerates endothelial cell dysfunction in atherosclerosis by adsorbing miR-637 to enhance WNT4 expression."	hsa_circ_0003204	circUSP36 	hsa_circ_USP36	USP36	atherosclerosis	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"In ox-LDL-induced endothelial dysfunction (an in vitro atherosclerosis model), circUSP36 is up-regulated and functions as a miRNA sponge for miR-637. Through the circUSP36/miR-637/WNT4 axis, circUSP36 modulates endothelial cell proliferation and migration and is proposed as a potential diagnostic/therapeutic biomarker for atherosclerosis."	0.7812
34519628	Bioengineered	2021	Circular RNA PUM1 (CircPUM1) attenuates trophoblast cell dysfunction and inflammation in recurrent spontaneous abortion via the MicroRNA-30a-5p (miR-30a-5p)/JUNB axis.		Circular RNA PUM1 	hsa_circ_PUM1	PUM1	recurrent spontaneous abortion 	MONDO:0005047	infertility disorder	down-regulated	RT-qPCR	"circPUM1 is down-regulated in RSA placental tissues. Functionally, circPUM1 supports trophoblast proliferation/migration/invasion and suppresses apoptosis and inflammatory cytokine secretion by acting as a ceRNA sponge for miR-30a-5p to upregulate JUNB."	0.7045
34520391	Aging	2021	Circular RNA ZNF609 enhances proliferation and glycolysis during glioma progression by miR-378b/SLC2A1 axis.		circular RNA ZNF609 	hsa_circ_ZNF609	ZNF609	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circZNF609 is up-regulated in clinical glioma samples and promotes glioma proliferation, invasion/migration, EMT-like changes, and glycolysis while suppressing apoptosis. Mechanistically it sponges miR-378b to increase SLC2A1 (GLUT1) expression, and its knockdown suppresses xenograft tumor growth."	0.7294
34521346	BMC cardiovascular disorders	2021	Construction and investigation of a circRNA-associated ceRNA regulatory network in Tetralogy of Fallot.	hsa_circ_0007798				Tetralogy of Fallot 	MONDO:0008542	tetralogy of fallot	up-regulated	RT-qPCR; Microarray	"hsa_circ_0007798 is up-regulated in TOF heart tissues and is highlighted as a key circRNA in a predicted ceRNA network. The study proposes a hsa_circ_0007798/miR-199b-5p/HIF1A axis, supported by qPCR expression validation and a positive correlation between hsa_circ_0007798 and HIF1A in clinical samples."	0.4032
34522177	International journal of medical sciences	2021	Downregulation of circ_0000673 Promotes Cell Proliferation and Migration in Endometriosis via the Mir-616-3p/PTEN Axis.	hsa_circ_0000673	circ_0000673 	hsa_circ_RSL1D1	RSL1D1	endometriosis 	MONDO:0005133	endometriosis	down-regulated	RT-qPCR; ISH	"circ_0000673 is down-regulated in ectopic endometrium in endometriosis and mainly localizes to the cytoplasm. Its knockdown promotes endometrial stromal cell proliferation and migration by sponging miR-616-3p, thereby suppressing PTEN and activating PI3K/AKT signaling."	0.6815
34523261	Thoracic cancer	2021	Identification of circ_0058357 as a regulator in non-small cell lung cancer cells resistant to cisplatin by miR-361-3p/ABCC1 axis.	hsa_circ_0058357	circ_0058357	hsa_circ_ATG9A	ATG9A	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0058357 is up-regulated in cisplatin (DDP)-resistant NSCLC tissues and resistant cell lines. It promotes malignant phenotypes and DDP resistance by sponging miR-361-3p to de-repress ABCC1, thereby enhancing ABCC1 expression and reducing DDP sensitivity."	0.786
34523694	Molecular medicine reports	2021	"Circular RNA hsa_circ_0026552 inhibits the proliferation, migration and invasion of trophoblast cells via the miR_331_3p/TGF_betaR1 axis in pre_eclampsia."	hsa_circ_0026552				pre-eclampsia 	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR; Microarray	"hsa_circ_0026552 is up-regulated in pre-eclampsia placental tissues. Functionally, its overexpression suppresses trophoblast proliferation, migration and invasion, and it mechanistically acts as a ceRNA by sponging miR-331-3p to increase TGF-betaR1 expression, affecting PE progression."	0.7283
34523755	Journal of clinical laboratory analysis	2021	Plasma circular RNA hsa_circ_0001821 acts as a novel diagnostic biomarker for malignant tumors.	hsa_circ_0001821	hsa_circ_001821	hsa_circ_PVT1	PVT1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"The study reports that plasma hsa_circ_0001821 is up-regulated in CRC (also in HCC and lung cancer) and can serve as a noninvasive diagnostic biomarker with ROC performance. In CRC, higher plasma levels are associated with advanced stage and poorer overall survival, and hsa_circ_0001821 is an independent prognostic predictor in Cox regression."	0.4992
34524260	Journal of cardiovascular pharmacology	2021	CircRNA MFACR Is Upregulated in Myocardial Infarction and Downregulates miR-125b to Promote Cardiomyocyte Apoptosis Induced by Hypoxia.		circRNA MFACR 			myocardial infarction 	MONDO:0005068	myocardial infarction	up-regulated	RT-qPCR	"In myocardial infarction, MFACR is upregulated and promotes hypoxia-induced cardiomyocyte apoptosis. Mechanistically, MFACR reduces miR-125b levels by increasing methylation of the miR-125b gene, and miR-125b overexpression reverses MFACR¡¯s pro-apoptotic effects in vitro and in vivo."	0.6578
34526098	Journal of experimental & clinical cancer research : CR	2021	circHMGCS1-016 reshapes immune environment by sponging miR-1236-3p to regulate CD73 and GAL-8 expression in intrahepatic cholangiocarcinoma.	hsa_circ_0008621	circHMGCS1_016 	hsa_circ_HMGCS1	HMGCS1	intrahepatic cholangiocarcinoma 	MONDO:0003210	intrahepatic cholangiocarcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circHMGCS1_016 (hsa_circ_0008621), derived from HMGCS1, is up-regulated in ICC tissues and promotes ICC cell proliferation, invasion and metastasis. Mechanistically, it sponges miR-1236-3p to increase CD73 and GAL-8, leading to an immunosuppressive microenvironment with reduced T cell activity and decreased responsiveness to anti-PD1 therapy. High circHMGCS1_016 in tumors is associated with poorer survival and higher recurrence."	0.8933
34526791	"Diabetes, metabolic syndrome and obesity : targets and therapy"	2021	Understanding Competitive Endogenous RNA Network Mechanism in Type 1 Diabetes Mellitus Using Computational and Bioinformatics Approaches.	hsa_circ_0002202		hsa_circ_SAMD4A	SMAD4A	Type 1 diabetes mellitus 	MONDO:0005147	type 1 diabetes mellitus	up-regulated	RT-qPCR; Microarray	"hsa_circ_0002202 is up-regulated in PBMCs from T1DM patients and is mainly localized in the cytoplasm of THP-1-derived macrophages. Functional knockdown experiments indicate it promotes IFN-I-induced inflammatory responses, and bioinformatic ceRNA analysis links it to a miRNA-mediated regulatory module (miR-495-3p/miR-668-3p/miR-508-3p/miR-487a-3p) targeting GREM2."	0.3514
34528696	International journal of molecular medicine	2021	circ_Grm1 promotes pulmonary artery smooth muscle cell proliferation and migration via suppression of GRM1 expression by FUS.	mmu_circ_0001907	circ-Grm1 	mmu_circ_Grm1	Grm1	hypoxic pulmonary hypertension 	MONDO:0005149	pulmonary hypertension	up-regulated	RT-qPCR; RNA-seq	"In hypoxia-induced pulmonary hypertension models, circ-Grm1 is upregulated and promotes PASMC proliferation and migration. Mechanistically, circ-Grm1 binds the RBP FUS to suppress Grm1 mRNA stability/expression, thereby inhibiting Rap1 signaling and enhancing ERK1 phosphorylation."	0.7204
34528912	Journal of microbiology and biotechnology	2021	Hsa_Circ_0001947/MiR-661/DOK7 Axis Restrains Non-Small Cell Lung Cancer Development.	hsa_circ_0001947	circ_0001947	hsa_circ_DOK7	DOK7	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"In NSCLC, circ_0001947 is down-regulated and functions as a tumor suppressor. It sponges miR-661 to relieve repression of DOK7, thereby inhibiting viability/proliferation and promoting apoptosis with cell-cycle effects."	0.6521
34530825	Cancer cell international	2021	Circ-SFMBT2 drives the malignant phenotypes of esophageal cancer by the miR-107-dependent regulation of SLC1A5.	hsa_circ_0000211	circ-SFMBT2 	hsa_circ_SFMBT2	SFMBT2	esophageal cancer 	MONDO:0007576	esophageal cancer	up-regulated	RT-qPCR; Microarray	"circ-SFMBT2 is up-regulated in esophageal cancer tissues/cells and mainly localizes in the cytoplasm. It promotes malignant phenotypes (proliferation, invasion, glutamine metabolism and in vivo tumor growth) by sponging miR-107 and thereby increasing SLC1A5 expression; high circ-SFMBT2 correlates with poorer overall survival."	0.828
34531664	OncoTargets and therapy	2021	CircPTCH1 Promotes Migration in Lung Cancer by Regulating MYCN Expression Through miR-34c-5p.		circPTCH1	hsa_circ_PTCH1	PTCH1	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; RNA-seq	"circPTCH1 is up-regulated in lung cancer tissues/cell lines and is higher in metastatic samples. It promotes lung cancer cell migration, invasion and EMT by sponging miR-34c-5p to increase MYCN expression."	0.8382
34532284	Frontiers in oncology	2021	Comprehensive Analysis of circRNA Expression Profiles During Cervical Carcinogenesis.	hsa_circ_0001955		hsa_circ_CSNK1G1	CSNK1G1	cervical carcinogenesis 	MONDO:0005131	cervical carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circ_0001955 is continuously upregulated from NC to HSIL and CSCC. The study supports a ceRNA role for hsa_circ_0001955 involving hsa-miR-6719-3p/CDK1 and hsa-miR-1277-5p/NEDD4L during cervical carcinogenesis.	0.4032
34532284	Frontiers in oncology	2021	Comprehensive Analysis of circRNA Expression Profiles During Cervical Carcinogenesis.	hsa_circ_0003954		hsa_circ_NEDD4L	NEDD4L	cervical carcinogenesis 	MONDO:0005131	cervical carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0003954 is continuously upregulated from NC to HSIL and CSCC and is higher in SiHa than HcerEpic cells. Silencing hsa_circ_0003954 inhibits SiHa proliferation and induces G1 cell-cycle arrest, and its expression is consistent with a proposed hsa_circ_0003954/hsa-miR-15a-3p/SYCP2 ceRNA axis."	0.5923
34532373	Annals of translational medicine	2021	CircRNA hsa_circ_0006220 acts as a tumor suppressor gene by regulating miR-197-5p/CDH19 in triple-negative breast cancer.	hsa_circ_0006220		hsa_circ_TADA2A	TADA2A	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	down-regulated	RT-qPCR	"hsa_circ_0006220 is down-regulated in TNBC tissues and cell lines. It suppresses TNBC cell proliferation, migration, and invasion by acting as a ceRNA sponge for miR-197-5p, thereby increasing CDH19 expression."	0.6521
34532379	Annals of translational medicine	2021	hsa_circ_0000006 induces tumorigenesis through miR-361-3p targeting immunoglobulin-like domains protein 1 (LRIG1) in osteosarcoma.	hsa_circ_0000006				osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0000006 is down-regulated in osteosarcoma tissues and cell lines. Functionally, it promotes OS malignant phenotypes (proliferation, migration, invasion and EMT) by sponging miR-361-3p and thereby regulating LRIG1 in a ceRNA axis."	0.7283
34532392	Annals of translational medicine	2021	Circular RNA _0015278 inhibits the progression of non-small cell lung cancer through regulating the microRNA 1278/SOCS6 gene axis.	hsa_circ_0015278		hsa_circ_KLHL20	KLHL20	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"circ_0015278 is down-regulated in NSCLC and acts as a tumor suppressor. It sponges miR-1278 to relieve repression of SOCS6, thereby inhibiting proliferation, invasion and EMT and promoting apoptosis, and it suppresses xenograft tumor growth. Low circ_0015278 expression is associated with worse patient survival."	0.8824
34532478	Annals of translational medicine	2021	CircMMP1 promotes colorectal cancer growth and metastasis by sponging miR-1238 and upregulating MMP family expression.	hsa_circ_0024109	circMMP1 	hsa_circ_MMP1	MMP1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circMMP1 (hsa_circ_0024109) is up-regulated in colorectal cancer tissues and cell lines and mainly localizes in the cytoplasm. Functionally, circMMP1 promotes CRC proliferation, invasion and metastasis. Mechanistically, it sponges miR-1238 to relieve repression of MMP1/MMP2/MMP9, increasing their expression and driving CRC progression."	0.84
34532485	Annals of translational medicine	2021	Involvement of ferroptosis in the granulosa cells proliferation of PCOS through the circRHBG/miR-515/SLC7A11 axis.		circRHBG 	hsa_circ_RHBG	RHBG	Polycystic ovary syndrome 	MONDO:0008487	polycystic ovary syndrome	up-regulated	RT-qPCR; Microarray	"circRHBG (hsa_circ_0014734), derived from RHBG, is upregulated in granulosa cells from PCOS patients. Functionally, circRHBG supports granulosa cell proliferation and suppresses ferroptosis by sponging miR-515-5p, thereby modulating SLC7A11 in a ceRNA axis."	0.725
34534547	The Journal of biological chemistry	2021	A peptide CORO1C-47aa encoded by the circular noncoding RNA circ-0000437 functions as a negative regulator in endometrium tumor angiogenesis.	hsa_circ_0000437		hsa_circ_CORO1C	CORO1C	endometrial cancer 	MONDO:0011962	endometrial cancer	down-regulated	RT-qPCR; Northern Blot; ISH; RNA-seq	"In endometrial cancer, circ-0000437 is down-regulated and encodes the peptide CORO1C-47aa. CORO1C-47aa binds ARNT (PAS-B domain), disrupts ARNT_TACC3 coactivation, suppresses VEGF/VEGFA signaling, and thereby inhibits tumor angiogenesis and reduces xenograft growth."	0.8536
34535085	"Molecular medicine (Cambridge, Mass.)"	2021	Circular RNA-0007059 protects cell viability and reduces inflammation in a nephritis cell model by inhibiting microRNA-1278/SHP-1/STAT3 signaling.	hsa_circ_0007059	Circular RNA-0007059 			lupus nephritis 	MONDO:0005556	lupus nephritis	down-regulated	RT-qPCR; Microarray	"circ_0007059 is down-regulated in lupus nephritis specimens and IFN-treated renal cells. Its overexpression protects renal mesangial/HEK293 cells by restoring proliferation/viability and suppressing IFN-induced apoptosis and inflammatory gene expression, mainly via sponging miR-1278 to increase SHP-1 and reduce STAT3 phosphorylation."	0.7416
34537072	Respiratory research	2021	Circ_PIP5K1A regulates cisplatin resistance and malignant progression in non-small cell lung cancer cells and xenograft murine model via depending on miR-493-5p/ROCK1 axis.	hsa_circ_0014130	circ_PIP5K1A	hsa_circ_PIP5K1A	PIP5K1A	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_PIP5K1A is upregulated in cisplatin (DDP)-resistant NSCLC tissues and resistant cell lines. It promotes chemoresistance and malignant behaviors by sponging miR-493-5p, thereby increasing ROCK1 expression, and it modulates DDP response in a cell line-derived xenograft model."	0.7857
34539405	Frontiers in pharmacology	2021	Identification of Circular RNAs Circ_0005008 and Circ_0005198 in Plasma as Novel Biomarkers for New-Onset Rheumatoid Arthritis.	hsa_circ_0005008	Circ_0005008	hsa_circ_HNRNPA1P48	HNRNPA1P48	rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; Microarray	"circ_0005008 is significantly up-regulated in plasma from new-onset RA patients versus healthy controls, correlates with RA activity indices (DAS28, ESR, CRP, RF), and shows diagnostic value by ROC analysis; no functional mechanism was validated in RA-FLSs because circ_0005008 was not detectable there."	0.5963
34539405	Frontiers in pharmacology	2021	Identification of Circular RNAs Circ_0005008 and Circ_0005198 in Plasma as Novel Biomarkers for New-Onset Rheumatoid Arthritis.	hsa_circ_0005198	Circ_0005198	hsa_circ_PARP4	PARP4	rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; Microarray	"circ_0005198 is significantly up-regulated in plasma from new-onset RA patients and in RA-FLSs, correlates with disease activity measures (including DAS28), and has diagnostic value by ROC analysis. Mechanistically, it is proposed to act via interaction with miR-4778-3p based on miRNA prediction and a negative expression correlation in RA-FLSs."	0.5963
34539783	Journal of oncology	2021	Identification of Differentially Expressed Circular RNAs as miRNA Sponges in Lung Adenocarcinoma.	hsa_circ_0072088		hsa_circ_ZFR	ZFR	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	Microarray	"hsa_circ_0072088 is up-regulated in LUAD based on GEO microarray datasets and is proposed to act as a miRNA sponge within a constructed circRNA_miRNA_mRNA ceRNA network, with potential diagnostic value."	0.1768
34539783	Journal of oncology	2021	Identification of Differentially Expressed Circular RNAs as miRNA Sponges in Lung Adenocarcinoma.	hsa_circ_0003528		hsa_circ_SEC24A	SEC24A	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	Microarray	"hsa_circ_0003528 is up-regulated in LUAD based on GEO microarray datasets and is proposed as a cancer-specific circRNA that may act as a miRNA sponge in a ceRNA network, with potential diagnostic value."	0.1768
34539783	Journal of oncology	2021	Identification of Differentially Expressed Circular RNAs as miRNA Sponges in Lung Adenocarcinoma.	hsa_circ_0008274		hsa_circ_UGGT2	UGGT2	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	Microarray	"hsa_circ_0008274 is up-regulated in LUAD in GEO microarray datasets and was identified as a cancer-specific circRNA candidate with many predicted MREs, suggesting a potential miRNA-sponge (ceRNA) role and diagnostic value."	0.1768
34539783	Journal of oncology	2021	Identification of Differentially Expressed Circular RNAs as miRNA Sponges in Lung Adenocarcinoma.	hsa_circ_0003162		hsa_circ_BBS9	BBS9	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	down-regulated	Microarray	"hsa_circ_0003162 is down-regulated in LUAD and was identified bioinformatically as a cancer-specific circRNA candidate with predicted MREs, supporting a potential ceRNA/miRNA-sponge role and diagnostic relevance."	0.1768
34539783	Journal of oncology	2021	Identification of Differentially Expressed Circular RNAs as miRNA Sponges in Lung Adenocarcinoma.	hsa_circ_0029426		hsa_circ_RAN	RAN	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	down-regulated	Microarray	"hsa_circ_0029426 is down-regulated in LUAD and was incorporated into a predicted circRNA_miRNA_mRNA ceRNA network; downstream mRNAs associated with this network were enriched in pathways including PI3K-Akt and HIF-1 signaling, supporting potential diagnostic relevance."	0.1768
34539783	Journal of oncology	2021	Identification of Differentially Expressed Circular RNAs as miRNA Sponges in Lung Adenocarcinoma.	hsa_circ_0049271		hsa_circ_KEAP1	KEAP1	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	down-regulated	Microarray	"hsa_circ_0049271 is down-regulated in LUAD and was included in the predicted ceRNA network; downstream target mRNAs linked to this network show enrichment in PI3K-Akt and HIF-1 signaling pathways, suggesting potential diagnostic value."	0.1768
34539783	Journal of oncology	2021	Identification of Differentially Expressed Circular RNAs as miRNA Sponges in Lung Adenocarcinoma.	hsa_circ_0043256		hsa_circ_ACACA	ACACA	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	down-regulated	Microarray	"hsa_circ_0043256 is down-regulated in LUAD and was identified as a cancer-specific DEcircRNA in a predicted ceRNA network, suggesting a potential miRNA-sponge role and possible diagnostic relevance; prior literature is noted to link it to cancer progression."	0.1768
34539866	Oncology letters	2021	circRNA circ_POLA2 increases microRNA-31 methylation to promote endometrial cancer cell proliferation.		circ_POLA2 	hsa_circ_POLA2	POLA2	endometrial cancer 	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR	"circ_POLA2 is up-regulated in endometrial cancer tissues and promotes EC cell proliferation. Mechanistically, circ_POLA2 increases methylation of the miR-31 gene, reducing miR-31 expression and attenuating the anti-proliferative effect of miR-31 in EC cells."	0.6102
34540823	Frontiers in cell and developmental biology	2021	CircGLIS3 Promotes High-Grade Glioma Invasion via Modulating Ezrin Phosphorylation.	hsa_circ_0002874	circGLIS3	hsa_circ_GLIS3	GLIS3	high-grade glioma 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; Microarray	"circGLIS3 (hsa_circ_0002874, from GLIS3 exon 2) is up-regulated in high-grade glioma and promotes glioma migration/invasion in vitro and invasive behavior in intracranial xenografts. Mechanistically, it localizes to the cytoplasm and directly binds phosphorylated Ezrin(T567), increasing p-Ezrin(T567) levels to enhance motility. circGLIS3 can also be packaged into glioma-derived exosomes, transferred to endothelial cells, and promote angiogenesis with increased Ezrin T567 phosphorylation."	0.8806
34542161	Molecular medicine reports	2021	"Silencing circ_BIRC6 inhibits the proliferation, invasion, migration and epithelial_mesenchymal transition of bladder cancer cells by targeting the miR_495_3p/XBP1 signaling axis."			hsa_circ_BIRC6	BIRC6	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"In bladder cancer cell lines and xenografts, circ-BIRC6 is upregulated and promotes proliferation, invasion, migration and EMT. Mechanistically, circ-BIRC6 functions as a ceRNA by sponging miR-495-3p to increase XBP1 expression, thereby enhancing tumor growth and EMT-related protein changes."	0.6544
34545330	BioMed research international	2021	Screening and Bioinformatics Analysis of Competitive Endogenous RNA Regulatory Network --Related to Circular RNA in Breast Cancer.	hsa_circ_0001806				breast cancer	MONDO:0007254	breast cancer	unknown	Microarray	"hsa_circ_0001806 was included as one of the circRNAs in a GEO-derived, predicted ceRNA (circRNA_miRNA_mRNA) network for breast cancer. The study did not report its specific deregulation direction, interacting miRNAs, or downstream targets individually, and no experimental validation was provided for this circRNA."	0.1768
34545330	BioMed research international	2021	Screening and Bioinformatics Analysis of Competitive Endogenous RNA Regulatory Network --Related to Circular RNA in Breast Cancer.	hsa_circ_0007618				breast cancer	MONDO:0007254	breast cancer	unknown	Microarray	"hsa_circ_0007618 was included as one of the circRNAs in a predicted ceRNA network constructed from breast cancer GEO datasets. The article did not provide circRNA-specific expression direction, interactors, or experimental validation for this circRNA."	0.1768
34545330	BioMed research international	2021	Screening and Bioinformatics Analysis of Competitive Endogenous RNA Regulatory Network --Related to Circular RNA in Breast Cancer.	hsa_circ_0091449				breast cancer	MONDO:0007254	breast cancer	unknown	Microarray	hsa_circ_0091449 was one of the circRNAs included in the constructed breast cancer ceRNA network based on GEO expression profiles and target prediction databases. No circRNA-specific mechanistic or clinical findings were reported for this circRNA.	0.1768
34545330	BioMed research international	2021	Screening and Bioinformatics Analysis of Competitive Endogenous RNA Regulatory Network --Related to Circular RNA in Breast Cancer.	hsa_circ_0043278				breast cancer	MONDO:0007254	breast cancer	unknown	Microarray	"hsa_circ_0043278 was incorporated into a breast cancer ceRNA network generated via differential expression (GEO microarray) and interaction prediction. The study did not present individualized validation, targets, or clinical relevance for this circRNA."	0.1768
34545330	BioMed research international	2021	Screening and Bioinformatics Analysis of Competitive Endogenous RNA Regulatory Network --Related to Circular RNA in Breast Cancer.	hsa_circ_0000977				breast cancer	MONDO:0007254	breast cancer	unknown	Microarray	hsa_circ_0000977 was part of the study¡¯s breast cancer circRNA-related ceRNA network derived from GEO differential expression and database-based target predictions. No direct experimental validation or specific functional axis was reported for this circRNA.	0.1768
34545330	BioMed research international	2021	Screening and Bioinformatics Analysis of Competitive Endogenous RNA Regulatory Network --Related to Circular RNA in Breast Cancer.	hsa_circ_0072088				breast cancer	MONDO:0007254	breast cancer	unknown	Microarray	"hsa_circ_0072088 was included among the circRNAs forming the study¡¯s breast cancer ceRNA network from GEO microarray data and in-silico interaction prediction. The paper did not report its specific expression direction, miRNA/mRNA partners, or clinical associations."	0.1768
34545330	BioMed research international	2021	Screening and Bioinformatics Analysis of Competitive Endogenous RNA Regulatory Network --Related to Circular RNA in Breast Cancer.	hsa_circ_0001625				breast cancer	MONDO:0007254	breast cancer	unknown	Microarray	"hsa_circ_0001625 was mentioned among DEcircRNAs, but the authors reported that CSCD contained no target-miRNA information for it, so it was not characterized further in the ceRNA network. No circRNA-specific mechanism, targets, or validation were provided."	0.1768
34545623	Journal of clinical laboratory analysis	2021	"Circular RNA MTO1 intercorrelates with microRNA-630, both associate with Enneking stage and/or pathological fracture as well as prognosis in osteosarcoma patients."		circ_MTO1 	hsa_circ_MTO1	MTO1	osteosarcoma	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR	"In osteosarcoma patient tissues, circ-MTO1 is down-regulated in tumors versus adjacent non-tumor tissues. Higher tumor circ-MTO1 levels correlate with milder disease (lower Enneking stage), better neoadjuvant chemotherapy response, and longer DFS, and circ-MTO1 is negatively correlated with miR-630 expression."	0.5261
34545638	Journal of clinical laboratory analysis	2021	Serum Circ-FAF1/Circ-ELP3: A novel potential biomarker for breast cancer diagnosis.	hsa_circ_0001785	Circ-ELP3	hsa_circ_ELP3	ELP3	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"In this case-control cohort, serum Circ-ELP3 (hsa_circ_0001785) is elevated in pre-treatment breast cancer patients and decreases after therapy. It shows moderate diagnostic performance by ROC analysis and contributes to improved diagnostic accuracy when combined with Circ-FAF1."	0.4187
34545638	Journal of clinical laboratory analysis	2021	Serum Circ-FAF1/Circ-ELP3: A novel potential biomarker for breast cancer diagnosis.	hsa_circ_100219	Circ-FAF1	hsa_circ_FAF1	FAF1	breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	"In this case-control cohort, serum Circ-FAF1 (hsa_circ_100219) is reduced in pre-treatment breast cancer patients and increases after treatment. It has diagnostic value by ROC analysis and enhances diagnostic performance when combined with Circ-ELP3."	0.4187
34546850	Bioengineered	2021	Circular RNA PIP5K1A (circPIP5K1A) accelerates endometriosis progression by regulating the miR-153-3p/Thymosin Beta-4 X-Linked (TMSB4X) pathway.	hsa_circ_0014130	circPIP5K1A	hsa_circ_PIP5K1A	PIP5K1A	endometriosis 	MONDO:0005133	endometriosis	up-regulated	RT-qPCR	"circPIP5K1A is upregulated in endometriosis tissues and hEM15A cells. It promotes proliferation, cell-cycle progression, migration/invasion and inhibits apoptosis by sponging miR-153-3p to increase TMSB4X, which in turn activates TGF-beta signaling in vitro."	0.705
34546853	Bioengineered	2021	Circular RNA circ_RANBP9 exacerbates polycystic ovary syndrome via microRNA-136-5p/XIAP axis.	hsa_circ_0001577	circ_RANBP9 	hsa_circ_RANBP9	RANBP9	polycystic ovary syndrome 	MONDO:0008487	polycystic ovary syndrome	up-regulated	RT-qPCR	circ_RANBP9 is up-regulated in PCOS patient plasma and granulosa cell lines. It promotes granulosa-cell proliferation and inhibits apoptosis by sponging miR-136-5p and thereby increasing XIAP; silencing circ_RANBP9 reverses these effects.	0.7032
34547461	Molecular therapy : the journal of the American Society of Gene Therapy	2022	Circular RNA Cdyl promotes abdominal aortic aneurysm formation by inducing M1 macrophage polarization and M1-type inflammation.	hsa_circ_0008285	circCdyl 	hsa_circ_CDYl	Cdyl	abdominal aortic aneurysm 	MONDO:0005350	abdominal aortic aneurysm	up-regulated	RT-qPCR; ISH; Microarray	"circCdyl is up-regulated in mouse and human AAA tissues and promotes AAA formation by enhancing M1 macrophage polarization and M1-type inflammation. Mechanistically, it binds IRF4 to block its nuclear entry and also acts as a let-7c sponge to increase C/EBP-delta expression in macrophages."	0.8726
34547461	Molecular therapy : the journal of the American Society of Gene Therapy	2022	Circular RNA Cdyl promotes abdominal aortic aneurysm formation by inducing M1 macrophage polarization and M1-type inflammation.	mmu_circ_0000451	circCdyl 	mmu_circ_Cdyl	Cdyl	abdominal aortic aneurysm 	MONDO:0005350	abdominal aortic aneurysm	up-regulated	RT-qPCR; ISH; Microarray	"circCdyl is up-regulated in mouse and human AAA tissues and promotes AAA formation by enhancing M1 macrophage polarization and M1-type inflammation. Mechanistically, it binds IRF4 to block its nuclear entry and also acts as a let-7c sponge to increase C/EBP-delta expression in macrophages."	0.8726
34549306	Oncology reports	2021	Identification of the tumor_suppressive role of circular RNA_FOXO3 in colorectal cancer via regulation of miR_543/LATS1 axis.	hsa_circ_0006404	circ-FOXO3 	hsa_circ_FOXO3	FOXO3	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"circ-FOXO3 (hsa_circ_0006404) is down-regulated in colorectal cancer tissues and cell lines. Functionally, circ-FOXO3 suppresses CRC cell proliferation, migration and invasion by acting as a ceRNA that sponges miR-543 and thereby increases LATS1 expression. Low circ-FOXO3 expression is associated with poor overall survival and adverse clinicopathological features."	0.8244
34551195	Journal of cellular and molecular medicine	2021	Circular RNA WHSC1 exerts oncogenic properties by regulating miR-7/TAB2 in lung cancer.	hsa_circ_0004156	circ_WHSC1 	hsa_circ_WHSC1	WHSC1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ-WHSC1 (hsa_circ_0004156) is up-regulated in NSCLC tissues and cell lines and promotes proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, it functions as a ceRNA by sponging miR-7 to increase TAB2 expression, enhancing downstream p38 MAPK/IKKbeta signaling and accelerating NSCLC progression."	0.8439
34552818	Molecular therapy. Nucleic acids	2021	Circular RNA circDNA2 upregulates CCDC6 expression to promote the progression of gastric cancer via miR-149-5p suppression.		circDNA2	hsa_circ_DNA2	DNA2	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circDNA2 is up-regulated in gastric cancer and mainly localized in the cytoplasm. It promotes GC cell proliferation and lymphatic metastasis by sponging miR-149-5p, thereby increasing CCDC6 expression."	0.8588
34552819	Molecular therapy. Nucleic acids	2021	"circGNAQ, a circular RNA enriched in vascular endothelium, inhibits endothelial cell senescence and atherosclerosis progression."	hsa_circ_0006459	circGNAQ	hsa_circ_GNAQ	GNAQ	atherosclerosis 	MONDO:0005311	atherosclerosis	down-regulated	RT-qPCR; Northern Blot; RNA-seq	"circGNAQ (hsa_circ_0006459) is down-regulated in senescent endothelial cells and during atherosclerosis progression. It suppresses endothelial cell senescence and promotes proliferation/angiogenesis by sponging miR-146a-5p to de-repress PLK2, and its endothelial overexpression reduces atherosclerotic lesion formation in Ldlr_/_ mice."	0.8217
34552882	Frontiers in oncology	2021	Overexpression of Circular RNA circ_0013587 Reverses Erlotinib Resistance in Pancreatic Cancer Cells Through Regulating the miR-1227/E-Cadherin Pathway.	hsa_circ_0013587	circ_0013587			pancreatic cancer	MONDO:0009831	malignant pancreatic neoplasm	down-regulated	RT-qPCR	"circ_0013587 is down-regulated in pancreatic cancer, especially in erlotinib-resistant cells, and its restoration sensitizes pancreatic cancer cells to erlotinib while inhibiting proliferation, invasion and EMT. Mechanistically, circ_0013587 functions as a ceRNA by sponging miR-1227 to de-repress E-cadherin, thereby reversing erlotinib resistance in vitro and in xenograft models. Clinically, lower circ_0013587 levels are associated with worse overall survival."	0.7846
34553034	Molecular therapy oncolytics	2021	Circular RNA SERPINE2 promotes development of glioblastoma by regulating the miR-361-3p/miR-324-5p/BCL2 signaling pathway.		circSERPINE2 	hsa_circ_SERPINE2	SERPINE2	glioblastoma 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; Microarray	"circSERPINE2 is upregulated in glioblastoma tissues and cell lines and is mainly localized in the cytoplasm. It promotes glioblastoma proliferation and inhibits apoptosis by sponging miR-361-3p and miR-324-5p, thereby increasing BCL2 expression, and high circSERPINE2 correlates with poor prognosis."	0.8632
34555726	Translational oncology	2021	Hsa_circ_0088212-mediated miR-520 h/APOA1 axis inhibits osteosarcoma progression.	hsa_circ_0088212	circ_0088212			osteosarcoma	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; Microarray	"circ_0088212 is down-regulated in osteosarcoma tissues and cell lines. Its overexpression suppresses proliferation and invasion/migration and promotes apoptosis, including reduced tumor growth in a SW1353 xenograft model, mainly by sponging miR-520 h and thereby relieving repression of APOA1."	0.7914
34555810	Aging	2021	Circular RNA Foxo3 enhances progression of ovarian carcinoma cells.		Circular RNA Foxo3 	hsa_circ_Foxo3	Foxo3	ovarian carcinoma 	MONDO:0005140	ovarian carcinoma	up-regulated	RT-qPCR	"Foxo3 is up-regulated in ovarian carcinoma cell lines and promotes proliferation, migration, and invasion. Mechanistically, Foxo3 acts as a miRNA sponge for miR-422a to increase PLP2 expression, and it can be transferred via exosomes to enhance OC progression."	0.6157
34561612	Molecular psychiatry	2021	Obesity-linked circular RNA circTshz2-2 regulates the neuronal cell cycle and spatial memory in the brain.			mmu_circ_Tshz2	Tshz2	obesity 	MONDO:0011122	obesity disorder	up-regulated	RT-qPCR; RNA-seq	"In obese mouse brain, circTshz2-2 is up-regulated and acts as a repressive regulator of Bdnf transcription by associating with the YY1-CTBP-CTIP repressor complex. Its depletion increases BDNF/TrkB signaling, reduces Cyclin B2/CDK1, and drives neuronal G2/M arrest with enhanced neurite elongation/complexity, leading to context-dependent effects on spatial memory (worsened in WT, improved in obese)."	0.7142
34562344	The Kaohsiung journal of medical sciences	2021	"Circular RNA hsa_circ_0000730 restrains cell proliferation, migration, and invasion in cervical cancer through miR-942-5p/PTEN axis."	hsa_circ_0000730	circ_0000730			cervical cancer 	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0000730 (circ_0000730) is significantly down-regulated in cervical cancer tissues and cell lines, and its low expression is associated with worse overall survival. Functionally, circ_0000730 suppresses proliferation, migration, and invasion of cervical cancer cells by acting as a ceRNA that sponges miR-942-5p and thereby increases PTEN expression."	0.7325
34563140	BMC neurology	2021	Screening for differentially expressed circRNAs in ischemic stroke by RNA sequencing.	hsa_circ_0001459		hsa_circ_NEIL3	NEIL3	ischemic stroke	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0001459 is up-regulated in peripheral whole blood of ischemic stroke patients and shows diagnostic potential (AUC 0.800). The authors suggest it may affect ischemic stroke by regulating its host gene NEIL3 and it is predicted to share miR-140-5p as a target in the circRNA-miRNA network.	0.5963
34563140	BMC neurology	2021	Screening for differentially expressed circRNAs in ischemic stroke by RNA sequencing.	hsa_circ_0007706		hsa_circ_USP14	USP14	ischemic stroke	MONDO:1060198	ischemic stroke	unknown	RT-qPCR; RNA-seq	hsa_circ_0007706 is differentially expressed in ischemic stroke and is suggested to be implicated in disease in the context of its host gene USP14. It also appears in a circRNA-miRNA network sharing predicted miR-140-5p targeting and shows diagnostic potential by ROC analysis (AUC 0.809).	0.5963
34563140	BMC neurology	2021	Screening for differentially expressed circRNAs in ischemic stroke by RNA sequencing.	hsa_circ_0000745		hsa_circ_SPECC1	SPECC1	ischemic stroke	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000745 is up-regulated in peripheral whole blood from ischemic stroke patients and is proposed as a newly reported stroke-associated circRNA. It is included in a predicted circRNA-miRNA network (shared miR-140-5p) and shows diagnostic potential by ROC analysis (AUC 0.800), but requires further confirmation."	0.5963
34563140	BMC neurology	2021	Screening for differentially expressed circRNAs in ischemic stroke by RNA sequencing.	hsa_circ_0003694	circ-0003694	hsa_circ_SMAD2	SMAD2	ischemic stroke	MONDO:1060198	ischemic stroke	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0003694 shows inconsistent direction between RNA-seq (down) and qRT-PCR (up) in ischemic stroke blood samples, so it is best characterized as dysregulated with unclear direction. It is linked to host gene SMAD2 and appears in a predicted circRNA-miRNA network (shared miR-140-5p), and has moderate diagnostic value by ROC analysis (AUC 0.733)."	0.5963
34565283	Bioengineered	2021	Circular RNA hsa_circ_0000751 serves as a microRNA-488 sponge to suppress gastric cancer progression via ubiquinol-cytochrome c reductase core protein 2 regulation.	hsa_circ_0000751	circNUFIP2 	hsa_circ_NUFIP2	NUFIP2	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"In gastric cancer, hsa_circ_0000751 (circNUFIP2) is down-regulated and functions as a tumor suppressor. It sponges miR-488, relieving repression of UQCRC2 and thereby inhibiting proliferation and invasion/migration while promoting apoptosis, with in vivo xenograft suppression."	0.8175
34565284	Bioengineered	2021	Silencing circular RNA circ_0054537 and upregulating microRNA-640 suppress malignant progression of renal cell carcinoma via regulating neuronal pentraxin-2 (NPTX2).	hsa_circ_0054537	circ_0054537	hsa_circ_PSME4	PSME4	renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR	"circ_0054537 is up-regulated in RCC tissues and cell lines and mainly localizes to the cytoplasm. It promotes RCC malignant phenotypes (proliferation, migration/invasion, autophagy, glycolysis) and inhibits apoptosis by acting as a ceRNA that sponges miR-640 to derepress NPTX2; circ_0054537 knockdown suppresses xenograft tumor growth."	0.7923
34568326	Frontiers in cell and developmental biology	2021	Circular RNA hsa_circ_0000073 Enhances Osteosarcoma Cells Malignant Behavior by Sponging miR-1252-5p and Modulating CCNE2 and MDM2.	hsa_circ_0000073				osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"hsa_circ_0000073 is up-regulated in osteosarcoma cell lines and promotes malignant behaviors (proliferation, migration, invasion, cell-cycle progression) and tumorigenesis. Mechanistically, it functions as a ceRNA by sponging miR-1252-5p to regulate CCNE2 and MDM2 expression, supported by luciferase, RIP, and rescue experiments."	0.8124
34568335	Frontiers in cell and developmental biology	2021	Tumor Cell-Derived Exosomal Circ-0072088 Suppresses Migration and Invasion of Hepatic Carcinoma Cells Through Regulating MMP-16.		Circ-0072088 	hsa_circ_ZFR	ZFR	hepatic carcinoma 	MONDO:0002691	liver cancer	up-regulated	RT-qPCR; Microarray	"circ-0072088 is up-regulated in HCC tumor tissues and circulating serum/plasma exosomes, and higher levels associate with advanced clinicopathologic features and worse survival. Mechanistically, it localizes mainly to the cytoplasm and acts as a ceRNA sponging miR-375 to relieve repression of MMP-16, thereby promoting EMT-like changes and enhancing HCC cell migration/invasion; exosome-mediated transfer of circ-0072088 modulates metastasis and tumor growth in vivo."	0.8087
34569727	Cancer medicine	2021	Construction of circRNA-based ceRNA network and its prognosis-associated subnet of clear cell renal cell carcinoma.	hsa_circ_0001167		hsa_circ_PREX1	PREX1	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0001167 is down-regulated in ccRCC tissues and renal cancer cell lines and forms a prognosis-associated ceRNA axis with hsa-miR-595 and CCDC8. Knockdown of hsa_circ_0001167 decreases CCDC8 expression, and lower hsa_circ_0001167 level is linked to worse survival."	0.6432
34569727	Cancer medicine	2021	Construction of circRNA-based ceRNA network and its prognosis-associated subnet of clear cell renal cell carcinoma.	hsa_circ_0005019		hsa_circ_CHSY1	CHSY1	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0005019 was included in the ccRCC prognosis-associated ceRNA subnet and showed significantly lower expression in renal cancer cell lines than in HEK 293T, consistent with the subnet prediction."	0.2465
34569727	Cancer medicine	2021	Construction of circRNA-based ceRNA network and its prognosis-associated subnet of clear cell renal cell carcinoma.	hsa_circ_0031017		hsa_circ_TMCO3	TMCO3	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0031017 was part of the prognosis-associated ceRNA subnet and showed decreased expression in renal cancer cell lines versus HEK 293T, consistent with the subnet prediction."	0.2465
34572871	Cancers	2021	The Analysis of Platelet-Derived circRNA Repertoire as Potential Diagnostic Biomarker for Non-Small Cell Lung Cancer.		NRIP1 circRNA 	hsa_circ_NRIP1	NRIP1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	"This study identifies platelet-derived circNRIP1 as significantly down-regulated in NSCLC patients versus asymptomatic controls by RNA-seq and confirms it by RT-qPCR in an independent cohort. The decrease is most evident in late-stage NSCLC, supporting circNRIP1 as a potential liquid-biopsy biomarker for NSCLC detection and progression monitoring."	0.3588
34579723	Molecular cancer	2021	p113 isoform encoded by CUX1 circular RNA drives tumor progression via facilitating ZRF1/BRD4 transactivation.		circRNA of CUX1 	hsa_circ_CUX1	CUX1	neuroblastoma 	MONDO:0005072	neuroblastoma	unknown	RT-qPCR	"In neuroblastoma, the CUX1 circular RNA (ecircCUX1; hsa_circ_30402) promotes tumor growth and aggressiveness by encoding the peptide p113. p113 forms a transcriptional complex with ZRF1 and BRD4 to activate ALDH3A1, NDUFA1 and NDUFAF5, enhancing lipid metabolic reprogramming, fatty acid oxidation and mitochondrial complex I activity."	0.8871
34582677	Asian Pacific journal of cancer prevention : APJCP	2021	Circular RNAs 0064286 and 0000475: Potential Diagnostic Biomarkers in Hepatocellular Carcinoma.	hsa_circ_0064286	Circ_0064286			Hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"In serum from Egyptian HCC patients, hsa_circ_0064286 is significantly down-regulated and shows strong diagnostic performance by ROC analysis. Mechanistically, the paper proposes a ceRNA axis in which hsa_circ_0064286 sponges miR-421 to affect MAPK14, and also suggests potential interaction with the RBP EIF4AIII."	0.4187
34582677	Asian Pacific journal of cancer prevention : APJCP	2021	Circular RNAs 0064286 and 0000475: Potential Diagnostic Biomarkers in Hepatocellular Carcinoma.	hsa_circ_0000475				Hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"In serum from Egyptian HCC patients, hsa_circ_0000475 is significantly down-regulated and shows modest diagnostic performance by ROC analysis. The paper proposes that hsa_circ_0000475 may sponge miR-665, which is linked to regulation of the tumor suppressor target PTPRB, suggesting a possible role in HCC tumorigenesis."	0.4187
34584570	Oncology letters	2021	"circ-ACACA promotes proliferation, invasion, migration and glycolysis of cervical cancer cells by targeting the miR-582-5p/ERO1A signaling axis."		circ-ACACA 	hsa_circ_ACACA	ACACA	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ-ACACA is upregulated in cervical cancer cell lines and mainly localized in the cytoplasm. It promotes proliferation, invasion, migration and glycolysis while inhibiting apoptosis, at least partly by sponging miR-582-5p to increase ERO1A expression."	0.6742
34586741	Clinical and translational medicine	2021	CircIMMP2L promotes esophageal squamous cell carcinoma malignant progression via CtBP1 nuclear retention dependent epigenetic modification.	hsa_circ_0081964	CircIMMP2L	hsa_circ_IMMP2L	IMMP2L	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; Northern Blot; ISH; Microarray	"circIMMP2L is up-regulated in ESCC tissues and patient plasma and promotes ESCC invasion, migration, proliferation and metastasis. It directly binds CtBP1, enhances CtBP1 nuclear retention, and strengthens CtBP1_HDAC1 interaction to epigenetically repress E-cadherin and p21 transcription, supporting malignant progression and serving as a diagnostic/LNM and prognostic biomarker."	0.906
34588429	Cell death & disease	2021	Circular RNA hsa_circ_0043280 inhibits cervical cancer tumor growth and metastasis via miR-203a-3p/PAQR3 axis.	hsa_circ_0043280		hsa_circ_TADA2A	TADA2A	cervical cancer 	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR; ISH; Microarray	"hsa_circ_0043280 (from TADA2A) is down-regulated in cervical cancer and acts as a tumor suppressor. It sponges miR-203a-3p to restore PAQR3 expression, thereby inhibiting proliferation, migration/invasion, EMT and metastasis, with downstream suppression of AKT and ERK signaling."	0.8826
34588800	International journal of general medicine	2021	Identification of Three Potential circRNA Biomarkers of Polycystic Ovary Syndrome by Bioinformatics Analysis and Validation.	hsa_circ_0075691		hsa_circ_ATXN1	ATXN1	polycystic ovary syndrome 	MONDO:0008487	polycystic ovary syndrome	up-regulated	RT-qPCR; Microarray	hsa_circ_0075691 is up-regulated in PCOS follicular fluid and shows diagnostic potential by ROC analysis. It was included in a predicted circRNA-miRNA-mRNA ceRNA network (bioinformatics-based) but its downstream mechanism was not experimentally validated.	0.5047
34588800	International journal of general medicine	2021	Identification of Three Potential circRNA Biomarkers of Polycystic Ovary Syndrome by Bioinformatics Analysis and Validation.	hsa_circ_0075692		hsa_circ_ATXN1	ATXN1	polycystic ovary syndrome 	MONDO:0008487	polycystic ovary syndrome	up-regulated	RT-qPCR; Microarray	"hsa_circ_0075692 is up-regulated in PCOS follicular fluid and shows diagnostic potential (AUC 0.80). It is part of a bioinformatically predicted circRNA-miRNA-mRNA ceRNA network, without experimental validation of the downstream mechanism."	0.5047
34588800	International journal of general medicine	2021	Identification of Three Potential circRNA Biomarkers of Polycystic Ovary Syndrome by Bioinformatics Analysis and Validation.	hsa_circ_0085997				polycystic ovary syndrome 	MONDO:0008487	polycystic ovary syndrome	down-regulated	RT-qPCR; Microarray	"hsa_circ_0085997 is down-regulated in PCOS follicular fluid and has moderate diagnostic performance (AUC 0.75). It is included in a predicted ceRNA network, and the authors speculate it may sponge miR-346 and relate to inflammatory regulation, but the mechanism is not experimentally validated."	0.5047
34588984	Frontiers in pharmacology	2021	CircRNA Microarray Profiling Reveals hsa_circ_0058493 as a Novel Biomarker for Imatinib-Resistant CML.	hsa_circ_0058493	circ_0058493  	hsa_circ_RHBDD1	RHBDD1	Chronic myeloid leukemia 	MONDO:0011996	"chronic myelogenous leukemia, BCR-ABL1 positive"	up-regulated	RT-qPCR; Microarray	"hsa_circ_0058493 is up-regulated in PBMCs of imatinib nonresponding CML patients and is enriched in exosomes from imatinib-resistant CML cells. Functional knockdown in K562/G01 increases imatinib sensitivity, increases apoptosis, and reduces proliferation. Mechanistically, it is predicted to sponge miR-548b-3p (and miR-330-3p) based on bioinformatic analysis and expression trends."	0.7507
34589042	Frontiers in neurology	2021	Circular RNA circNF1 siRNA Silencing Inhibits Glioblastoma Cell Proliferation by Promoting the Maturation of miR-340.		circNF1 	hsa_circ_NF1	NF1	glioblastoma 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR	"circNF1 is up-regulated in glioblastoma and functions as an oncogenic circRNA by promoting GBM cell proliferation. Mechanistically, circNF1 binds miR-340 and suppresses its maturation, and miR-340 inhibition partially reverses the anti-proliferative effect of circNF1 silencing. High circNF1 level is associated with poor overall survival and acts as an independent prognostic factor."	0.7283
34589285	Molecular therapy. Nucleic acids	2021	Hepatocellular carcinoma progression mediated by hepatitis B virus-encoded circRNA HBV_circ_1 through interaction with CDK1.		HBV_circ_1			HBV-related hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Northern Blot; ISH; RNA-seq; Microarray	"HBV-encoded HBV_circ_1 is up-regulated in HBV-related HCC tissues and is associated with worse patient survival. Functional assays indicate HBV_circ_1 promotes proliferation, cell-cycle progression, migration/invasion and tumor growth while inhibiting apoptosis, mainly by directly binding to CDK1 and increasing CDK1 expression."	0.8536
34592064	Cancer science	2022	circUSP34 accelerates osteosarcoma malignant progression by sponging miR-16-5p.		circUSP34	hsa_circ_USP34	USP34	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circUSP34 is up-regulated in osteosarcoma cells and tissues and promotes malignant phenotypes (proliferation, migration, invasion) in vitro and tumor growth in a nude-mouse xenograft model. Mechanistically, it localizes to the cytoplasm and sponges miR-16-5p, supported by FISH colocalization, luciferase reporter assay, AGO2-RIP, and RNA pull-down; circUSP34 knockdown increases miR-16-5p and alters EMT-related markers."	0.8151
34592791	Journal of clinical laboratory analysis	2021	The expression profile and clinical application value of hsa_circ_0016148 in head and neck squamous cell carcinoma.	hsa_circ_0016148		hsa_circ_PIK3C2B	PIK3C2B	head and neck squamous cell carcinoma 	MONDO:0010150	head and neck squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0016148 is significantly down-regulated in HNSCC tissues and is associated with lymph node metastasis and clinical stage. It shows strong diagnostic performance (AUC 0.912) and lower expression independently predicts worse overall survival. Mechanistically, it is proposed (by bioinformatics) to act via a circRNA_miRNA_mRNA ceRNA network involving nine miRNAs."	0.5734
34592879	Bioengineered	2021	Blocking hsa_circ_0074027 suppressed non-small cell lung cancer chemoresistance via the miR-379-5p/IGF1 axis.	hsa_circ_0074027				non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0074027 (HC0074027) is up-regulated in docetaxel-resistant NSCLC tissues/cells and promotes chemoresistance. Mechanistically, it sponges miR-379-5p, thereby relieving miR-379-5p-mediated suppression of IGF1 and increasing IGF1 levels. High HC0074027 is associated with docetaxel resistance and poorer survival."	0.7466
34594413	Experimental and therapeutic medicine	2021	"circRNA_PTPRA functions as a sponge of miR-582-3p to regulate hepatocellular carcinoma cell proliferation, migration, invasion and apoptosis."		circRNA_PTPRA 	hsa_circ_PTPRA	PTPRA	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circRNA_PTPRA is upregulated in HCC cell lines and promotes malignant phenotypes by sponging miR-582-3p. Silencing circRNA_PTPRA increases miR-582-3p and suppresses proliferation, migration and invasion while promoting apoptosis, with rescue by miR-582-3p inhibition."	0.6253
34595108	Frontiers in oncology	2021	Circular RNA hsa_circ_0007507 May Serve as a Biomarker for the Diagnosis and Prognosis of Gastric Cancer.	hsa_circ_0007507		hsa_circ_RASA1	RASA1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0007507 is up-regulated in gastric cancer tissues and in patient serum, and shows diagnostic value by ROC analysis. It is mainly localized in the cytoplasm and may function via a predicted/partly tested circRNA_miRNA interaction network (ceRNA-like regulation). High serum expression is associated with recurrence and worse survival, and levels decrease after surgery, supporting use in dynamic monitoring."	0.7894
34595165	Frontiers in cell and developmental biology	2021	Circular RNA CircPPP1CB Suppresses Tumorigenesis by Interacting With the MiR-1307-3p/SMG1 Axis in Human Bladder Cancer.	hsa_circ_0119704	circPPP1CB	hsa_circ_PPP1CB	PPP1CB	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"CircPPP1CB is down-regulated in human bladder cancer and functions as a tumor suppressor. It mainly localizes to the cytoplasm and sponges miR-1307-3p, thereby relieving repression of SMG1 and inhibiting proliferation, angiogenesis, migration/invasion, metastasis-related phenotypes and EMT in vitro and in vivo."	0.8738
34595992	Bioengineered	2021	Circular RNA circCOL6A3_030 is involved in the metastasis of gastric cancer by encoding polypeptide.	hsa_circ_0006401	circCOL6A3_030 	hsa_circ_COL6A3	COL6A3	gastric cancer 	MONDO:0001056	gastric cancer	dysregulated	RT-qPCR; Microarray	"In gastric cancer, circCOL6A3_030 shows abnormal expression, being higher in lymph node metastasis cases. Functional assays indicate it promotes migration and in vivo liver metastasis mainly through translation into a 198-aa peptide (circCOL6A3_030_198aa), and it has potential value as a marker for lymph node metastasis."	0.8066
34596168	Medicine	2021	The profile analysis of circular RNAs in cervical cancer.	hsa_circ_0000745		hsa_circ_SPECC1	SPECC1	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000745 is up-regulated in CSCC tissues and is proposed to act through a ceRNA network by targeting miRNAs (e.g., hsa-miR-136) and affecting downstream genes such as E2F1/TFCP2/RBM41. Its overexpression is associated with promoting CSCC cell differentiation, proliferation, and metastasis."	0.4032
34596168	Medicine	2021	The profile analysis of circular RNAs in cervical cancer.	hsa_circ_0084927		hsa_circ_ESRP1	ESRP1	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0084927 is up-regulated in CSCC tissues and is proposed to function as a ceRNA by targeting miRNAs such as hsa-miR-520h, with downstream targets including KLHL2, ATPBD4, LHX8, and ZNF318. Its overexpression is associated with promoting CSCC cell differentiation, proliferation, and metastasis."	0.4032
34596168	Medicine	2021	The profile analysis of circular RNAs in cervical cancer.	hsa_circ_0002762		hsa_circ_CDK17	CDK17	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	hsa_circ_0002762 is significantly up-regulated in CSCC tissues versus normal controls based on microarray analysis and RT-qPCR validation. The study did not specify a dedicated downstream miRNA/mRNA mechanism for this circRNA.	0.4032
34596168	Medicine	2021	The profile analysis of circular RNAs in cervical cancer.	hsa_circ_0007905		hsa_circ_STX6	STX6	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	hsa_circ_0007905 is up-regulated in CSCC tissues versus normal controls based on microarray analysis and RT-qPCR validation. The study did not report a specific interacting miRNA/mRNA axis for this circRNA.	0.4032
34596168	Medicine	2021	The profile analysis of circular RNAs in cervical cancer.	hsa_circ_0078383		hsa_circ_TIAM2	TIAM2	cervical cancer 	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0078383 is down-regulated in CSCC tissues versus normal controls and is incorporated into a predicted circRNA_miRNA_mRNA (ceRNA) network. It is predicted to target miRNAs including hsa-miR-520h with downstream mRNAs such as PP2A/C, KLHL2, ATPBD4, LHX8, ZNF318 and SMOC2."	0.4032
34596168	Medicine	2021	The profile analysis of circular RNAs in cervical cancer.	hsa_circ_0075341		hsa_circ_MAPK9	MAPK9	cervical cancer 	MONDO:0002974	cervical cancer	dysregulated	RT-qPCR; Microarray	hsa_circ_0075341 shows inconsistent expression direction between the in-silico microarray analysis and RT-qPCR validation in CSCC tissues (opposite trends). The study did not establish a specific mechanistic axis for this circRNA.	0.4032
34596168	Medicine	2021	The profile analysis of circular RNAs in cervical cancer.	hsa_circ_0031027		hsa_circ_TMCO3	TMCO3	cervical cancer 	MONDO:0002974	cervical cancer	dysregulated	RT-qPCR; Microarray	hsa_circ_0031027 shows inconsistent expression direction between the in-silico microarray analysis and RT-qPCR validation in CSCC tissues (opposite trends). The paper does not provide a specific mechanistic pathway for this circRNA.	0.4032
34599150	Cell death discovery	2021	Hsa_circ_0011385 knockdown represses cell proliferation in hepatocellular carcinoma.	hsa_circ_0011385	circ_0011385	hsa_circ_EIF3I	EIF3I	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0011385 is up-regulated in HCC and promotes HCC cell proliferation and xenograft tumor growth. Mechanistically, it functions mainly in the cytoplasm as a ceRNA sponging miR-361-3p to upregulate STC2, and its transcription is activated by SP3. High circ_0011385 expression correlates with more aggressive clinicopathologic features and poorer survival."	0.8547
34600555	Journal of translational medicine	2021	Development of a two-circular RNA panel as potential prognostic biomarker for gastric cancer.	hsa_circ_0005092		hsa_circ_IPO7	IPO7	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0005092 (from IPO7) is upregulated in GC patients with good prognosis and its high expression is associated with longer RFS/OS. The study validates it by qRT-PCR and circularity/stability assays and uses it with hsa_circ_0002647 to build a prognostic circPanel; its ceRNA network is computationally predicted but not experimentally confirmed.	0.7047
34600555	Journal of translational medicine	2021	Development of a two-circular RNA panel as potential prognostic biomarker for gastric cancer.	hsa_circ_0002647		hsa_circ_EHMT1	EHMT1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0002647 (from EHMT1) is upregulated in GC patients with good prognosis and its high expression is associated with longer RFS/OS. The study validates it by qRT-PCR and circularity/stability assays and uses it with hsa_circ_0005092 to build a prognostic circPanel; its ceRNA network is computationally predicted but not experimentally confirmed.	0.7047
34603369	Frontiers in genetics	2021	Identification of Circular RNAs Associated With Chemoresistance in Colorectal Cancer.		hsacirc_002482			colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"hsacirc_002482 is down-regulated in 5-Fu- and cisplatin-resistant CRC cell lines. Its overexpression suppresses proliferation, increases apoptosis, and enhances chemosensitivity, potentially via a hsacirc_002482/hsa-miR-503-5p regulatory interaction predicted from circRNA_miRNA network analysis."	0.4852
34604037	Frontiers in oncology	2021	Machine Learning-Based Comparative Analysis of Pan-Cancer and Pan-Normal Tissues Identifies Pan-Cancer Tissue-Enriched circRNAs Related to Cancer Mutations as Potential Exosomal Biomarkers.		chr1_224952669_224968874_+	hsa_circ_DNAH14	DNAH14	cancer 	MONDO:0004992	cancer	up-regulated	RNA-seq	"chr1_224952669_224968874_+ (DNAH14-derived) is pan-cancer tissue-enriched and is elevated in multiple cancer tissues and in plasma exosomes from HCC and CRC patients, suggesting biomarker potential. Its increased expression in cancer appears increasingly transcription-driven and may be facilitated by a nearby splice acceptor mutation (chr1:224952669:G>A)."	0.1768
34604037	Frontiers in oncology	2021	Machine Learning-Based Comparative Analysis of Pan-Cancer and Pan-Normal Tissues Identifies Pan-Cancer Tissue-Enriched circRNAs Related to Cancer Mutations as Potential Exosomal Biomarkers.		chr1_224952669_224974153_+	hsa_circ_DNAH14	DNAH14	cancer 	MONDO:0004992	cancer	unknown	RNA-seq	chr1_224952669_224974153_+ is a DNAH14-derived circRNA related to the splice acceptor variant chr1:224952669:G>A and is highly expressed in plasma exosomes in both healthy controls and cancer patients; the study does not report a clear disease-specific up/down change or functional mechanism for this circRNA.	0.1768
34604037	Frontiers in oncology	2021	Machine Learning-Based Comparative Analysis of Pan-Cancer and Pan-Normal Tissues Identifies Pan-Cancer Tissue-Enriched circRNAs Related to Cancer Mutations as Potential Exosomal Biomarkers.		chr10_110964124_110965061_+	hsa_circ_SHOC2	SHOC2	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RNA-seq	"chr10_110964124_110965061_+ (SHOC2-derived) is elevated in plasma exosomes from CRC and is reported as mutation-related (chr10:110964124:G>-, splice acceptor variant), supporting its potential relevance as an exosomal cancer-associated circRNA."	0.1768
34604037	Frontiers in oncology	2021	Machine Learning-Based Comparative Analysis of Pan-Cancer and Pan-Normal Tissues Identifies Pan-Cancer Tissue-Enriched circRNAs Related to Cancer Mutations as Potential Exosomal Biomarkers.		chr2_45546731_45553730_-	hsa_circ_SRBD1	SRBD1	pancreatic adenocarcinoma 	MONDO:0006047	pancreatic adenocarcinoma	up-regulated	RNA-seq	"chr2_45546731_45553730_- (SRBD1-derived) is reported as mutation-related (chr2:45546731:C>A, splice donor variant) and is highly expressed in plasma exosomes from PAAD, indicating a cancer-associated exosomal circRNA signal in this cohort."	0.1768
34604044	Frontiers in oncology	2021	CircPTK2 Suppresses the Progression of Gastric Cancer by Targeting the MiR-196a-3p/AATK Axis.	hsa_circ_0005273	CircPTK2	hsa_circ_PTK2	PTK2	gastric cancer	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"circPTK2 (hsa_circ_0005273), derived from PTK2, is down-regulated in gastric cancer tissues and cell lines and functions as a tumor suppressor. It sponges miR-196a-3p to relieve repression of AATK, thereby inhibiting malignant behaviors (proliferation/migration/invasion), promoting apoptosis, and suppressing xenograft tumor growth, with downstream involvement of the STK39/p38 pathway."	0.8861
34604211	Frontiers in cell and developmental biology	2021	Circular RNA 0006349 Augments Glycolysis and Malignance of Non-small Cell Lung Cancer Cells Through the microRNA-98/MKP1 Axis.	hsa_circ_0006349	Circular RNA 0006349 			non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0006349 is up-regulated in NSCLC tissues and cell lines and functions as an oncogenic circRNA. It mainly localizes to the cytoplasm and acts as a ceRNA to sponge miR-98, thereby increasing MKP1 expression and promoting proliferation and glycolysis while reducing apoptosis in NSCLC cells."	0.7896
34605348	Bioengineered	2021	Circular RNA circPRKDC promotes tumorigenesis of gastric cancer via modulating insulin receptor substrate 2 (IRS2) and mediating microRNA-493-5p.		circPRKDC 	hsa_circ_PRKDC	PRKDC	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circPRKDC is up-regulated in gastric cancer tissues/serum and promotes GC cell proliferation/viability, migration, invasion and EMT, as well as xenograft tumor growth. Mechanistically, it functions as a ceRNA that sponges miR-493-5p to increase IRS2 expression, forming the circPRKDC/miR-493-5p/IRS2 axis with diagnostic potential."	0.7624
34607506	Bioengineered	2022	Downregulation of circular RNA circ-HN1 suppressed the progression of gastric cancer through the miR-485-5p/GSK3A pathway.	hsa_circ_0045602	circ-HN1 	hsa_circ_HN1	HN1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ-HN1 is up-regulated in gastric cancer tissues and cell lines and functions as a tumor promoter. Mechanistically, circ-HN1 sponges miR-485-5p to relieve repression of GSK3A, thereby promoting proliferation, migration, and invasion of GC cells; circ-HN1 knockdown suppresses these phenotypes."	0.7551
34611143	Cell death & disease	2021	Circular RNA UBE2Q2 promotes malignant progression of gastric cancer by regulating signal transducer and activator of transcription 3-mediated autophagy and glycolysis.		circUBE2Q2 	hsa_circ_UBE2Q2	UBE2Q2	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"circUBE2Q2 is upregulated in gastric cancer tissues/cells and promotes malignant phenotypes (proliferation, migration/invasion, metastasis) while enhancing glycolysis and suppressing autophagy. Mechanistically, it functions as a ceRNA by sponging miR-370-3p to de-repress STAT3 signaling, and it can also be packaged into exosomes to promote metastatic behavior via intercellular communication."	0.8837
34611229	Scientific reports	2021	CircRNA_0079586 and circRNA_RanGAP1 are involved in the pathogenesis of intracranial aneurysms rupture by regulating the expression of MPO.	hsa_circ_0079586	circRNA_0079586 	hsa_circ_IGF2BP3	IGF2BP3	intracranial aneurysm 	MONDO:0005291	brain aneurysm	up-regulated	RT-qPCR; Microarray	"circRNA_0079586 is up-regulated in endothelial cells from ruptured intracranial aneurysms and in turbulent-flow-treated HUVECs. It participates in an MPO-modulating axis (circRNA_0079586/miR-183-5p/MPO) supported by luciferase assays and gain/loss-of-function transfections, where higher circRNA_0079586 associates with lower miR-183-5p and higher MPO."	0.6432
34611229	Scientific reports	2021	CircRNA_0079586 and circRNA_RanGAP1 are involved in the pathogenesis of intracranial aneurysms rupture by regulating the expression of MPO.		circRNA_RanGAP1 	hsa_circ_RanGAP1	RanGAP1	intracranial aneurysm 	MONDO:0005291	brain aneurysm	up-regulated	RT-qPCR; Microarray	"circRNA_RanGAP1 is up-regulated in endothelial cells from ruptured intracranial aneurysms and in turbulent-flow-treated HUVECs. It contributes to an MPO-modulating axis (circRNA_RanGAP1/miR-877-3p/MPO), with luciferase and transfection experiments supporting that circRNA_RanGAP1 inversely associates with miR-877-3p and positively regulates MPO expression."	0.6432
34611269	Experimental & molecular medicine	2021	circSPG21 protects against intervertebral disc disease by targeting miR-1197/ATP1B3.	hsa_circ_0035875	circSPG21	hsa_circ_SPG21	SPG21	degenerative intervertebral disc disease 	MONDO:0011385	intervertebral disk degenerative disorder	down-regulated	RT-qPCR; ISH; Microarray	"circSPG21 is down-regulated in IVDD nucleus pulposus tissues/cells and protects against disc degeneration. It mainly acts as a cytoplasmic ceRNA that sponges miR-1197 to relieve repression of ATP1B3, thereby inhibiting NPC senescence and ECM catabolism and promoting ECM anabolism; therapeutic delivery of circSPG21 alleviates IVDD in a mouse tail-looping model."	0.8058
34616159	Journal of asthma and allergy	2021	Circular RNA ERBB2 Contributes to Proliferation and Migration of Airway Smooth Muscle Cells via miR-98-5p/IGF1R Signaling in Asthma.		circERBB2 	hsa_circ_ERBB2	ERBB2	asthma	MONDO:0004979	asthma	up-regulated	RT-qPCR	"circERBB2 is upregulated in bronchial biopsy samples from asthma patients and in PDGF-BB-stimulated human ASMCs. Functionally, circERBB2 promotes ASMC proliferation/migration and inflammatory responses while suppressing apoptosis by sponging miR-98-5p and thereby increasing IGF1R expression/signaling."	0.7289
34617876	Bioengineered	2021	Circular RNA circCRKL inhibits the proliferation of acute myeloid leukemia cells via the miR-196a-5p/miR-196b-5p/p27 axis.		circCRKL	hsa_circ_CRKL	CRKL	acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	down-regulated	RT-qPCR	"circCRKL is down-regulated in acute myeloid leukemia and functions as a tumor-suppressive circRNA by inhibiting AML cell proliferation, colony formation, and cell-cycle progression. Mechanistically, it acts as a ceRNA that sponges miR-196a-5p and miR-196b-5p, thereby relieving repression of p27 (CDKN1B) and promoting p27 expression."	0.8043
34620126	BMC cancer	2021	"Knockdown of circ_0011946 targets miR-216a-5p/BCL2L2 axis to regulate proliferation, migration, invasion and apoptosis of oral squamous cell carcinoma cells."	hsa_circ_0011946		hsa_circ_SCMH1	SCMH1	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circ_0011946 is up-regulated in OSCC tissues and cell lines and predominantly localizes to the cytoplasm. It promotes malignant phenotypes by sponging miR-216a-5p to relieve repression of BCL2L2, thereby enhancing proliferation/migration/invasion and reducing apoptosis; its knockdown suppresses xenograft tumor growth."	0.8442
34620840	Signal transduction and targeted therapy	2021	BUB1B and circBUB1B_544aa aggravate multiple myeloma malignancy through evoking chromosomal instability.		circBUB1B_544aa 	hsa_circ_BUB1B	BUB1B	multiple myeloma 	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR; ISH	"circBUB1B (encoding circBUB1B_544aa) is up-regulated in multiple myeloma and high levels are associated with inferior event-free survival. The translated product circBUB1B_544aa interacts with and phosphorylates CEP170 to induce chromosomal instability, promoting MM cell proliferation and drug resistance, and it can be secreted (exosome-associated) to affect microenvironmental cells."	0.8462
34621049	Cell death and differentiation	2022	Negative feedback of SNRK to circ-SNRK regulates cardiac function post-myocardial infarction.		circ-SNRK	rno_circ_SNRK	SNRK	heart failure 	MONDO:0005252	heart failure	down-regulated	RT-qPCR; Northern Blot; RNA-seq	"circ-SNRK is down-regulated in post-MI failing rat hearts and in hypoxia-treated cardiomyocytes. It functions mainly in the cytoplasm as a miR-33 sponge to increase SNRK protein, enhancing ATP production/mitochondrial function and reducing cardiomyocyte apoptosis, thereby improving cardiac function after MI. Its biogenesis is promoted by NOVA1 and negatively regulated by an SNRK-derived ~55 kDa peptide via a feedback loop."	0.8408
34621297	Frontiers in genetics	2021	CircDTL Functions as an Oncogene and Regulates Both Apoptosis and Ferroptosis in Non-small Cell Lung Cancer Cells.		CircDTL			Non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circDTL is up-regulated in NSCLC tissues/cell lines and functions as an oncogene. It mainly localizes to the cytoplasm and acts as a miRNA sponge for miR-1287-5p, thereby increasing GPX4 expression to suppress apoptosis and ferroptosis and promote malignant phenotypes; circDTL silencing enhances chemosensitivity and inhibits xenograft growth."	0.7099
34627193	BMC cancer	2021	CircCDC45 promotes the malignant progression of glioblastoma by modulating the miR-485-5p/CSF-1 axis.	hsa_circ_0062270	circCDC45 	hsa_circ_CDC45	CDC45	glioblastoma 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; Microarray	"circCDC45 is up-regulated in glioblastoma tissues/cells and functions as an oncogenic circRNA. It sponges miR-485-5p to increase CSF-1, thereby promoting proliferation, migration, invasion, and tumor growth in a xenograft model, and may serve as a plasma biomarker for GBM."	0.8119
34629820	World journal of gastroenterology	2021	CircRNA_0084927 promotes colorectal cancer progression by regulating miRNA-20b-3p/glutathione S-transferase mu 5 axis.	hsa_circ_0084927	circRNA_0084927 	hsa_circ_ESRP1	ESRP1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0084927 is up-regulated in colorectal cancer and promotes CRC cell proliferation, migration and invasion. It functions as a ceRNA by sponging miR-20b-3p to upregulate GSTM5 and activate the AKT/mTOR pathway, supporting CRC progression and showing diagnostic potential."	0.7113
34629900	Cancer management and research	2021	Circular RNA-Related CeRNA Network and Prognostic Signature for Patients with Osteosarcoma.	hsa_circ_0035554		hsa_circ_ANXA2	ANXA2	Osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0035554 (host gene ANXA2) is downregulated in osteosarcoma cell lines versus osteoblast controls and was included in the constructed circRNA_miRNA_mRNA ceRNA network. The authors suggest it may have diagnostic biomarker potential for OSA, though no specific downstream miRNA/mRNA axis was experimentally validated for this circRNA."	0.1904
34629900	Cancer management and research	2021	Circular RNA-Related CeRNA Network and Prognostic Signature for Patients with Osteosarcoma.	hsa_circ_0009034		hsa_circ_MAP3K5	MAP3K5	Osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0009034 (host gene MAP3K5) is downregulated in osteosarcoma cell lines versus osteoblast controls and was incorporated into a circRNA_miRNA_mRNA ceRNA network. The study suggests it may have diagnostic biomarker potential for OSA, but does not experimentally validate a specific miRNA/mRNA regulatory axis for this circRNA."	0.1904
34629900	Cancer management and research	2021	Circular RNA-Related CeRNA Network and Prognostic Signature for Patients with Osteosarcoma.	hsa_circ_0007440		hsa_circ_CTNNA1	CTNNA1	Osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0007440 (host gene CTNNA1) is downregulated in osteosarcoma cell lines and was used to construct a circRNA_miRNA_mRNA ceRNA network. The study proposes this circRNA as a potential diagnostic biomarker for OSA, without experimental validation of specific interacting miRNAs or targets for this circRNA."	0.1904
34629900	Cancer management and research	2021	Circular RNA-Related CeRNA Network and Prognostic Signature for Patients with Osteosarcoma.	hsa_circ_0003205		hsa_circ_CTNNA1	CTNNA1	Osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0003205 (host gene CTNNA1) is downregulated in osteosarcoma cell lines and was included in the circRNA-related ceRNA network. The authors propose it as a potential diagnostic biomarker for OSA, but do not provide circRNA-specific mechanistic validation beyond network construction and expression testing."	0.1904
34630706	Oncology letters	2021	Circular RNA ATAD1 is upregulated in acute myeloid leukemia and promotes cancer cell proliferation by downregulating miR-34b via promoter methylation.		circ-ATAD1 	hsa_circ_ATAD1	ATAD1	acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"circ-ATAD1 is upregulated in AML and is predominantly nuclear. Its overexpression increases methylation of the miR-34b promoter, suppresses miR-34b expression, and thereby promotes AML cell proliferation."	0.6336
34630853	Oxidative medicine and cellular longevity	2021	circ_0023461 Silencing Protects Cardiomyocytes from Hypoxia-Induced Dysfunction through Targeting miR-370-3p/PDE4D Signaling.	hsa_circ_0023461	circ_0023461	hsa_circ_ARAP1	ARAP1	Acute myocardial infarction 	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR; Microarray	"circ_0023461 is upregulated in AMI patient plasma and in hypoxia-treated AC16 cardiomyocytes. Silencing circ_0023461 protects cardiomyocytes from hypoxia-induced dysfunction by sponging miR-370-3p, thereby relieving repression of PDE4D and modulating apoptosis, inflammation/oxidative stress, and glycolytic metabolism."	0.7799
34631278	Molecular therapy. Nucleic acids	2021	LRRC4 mediates the formation of circular RNA CD44 to inhibitGBM cell proliferation.	hsa_circ_0021726	circ_0021726 	hsa_circ_CD44	CD44	glioblastoma multiforme 	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR	"circCD44 (hsa_circ_0021726), derived from CD44 exons 7_13, is down-regulated in GBM tissues and primary GBM cells and mainly localizes to the cytoplasm. Its re-expression suppresses GBM cell proliferation, colony formation and invasion, and inhibits xenograft/orthotopic tumor growth. Mechanistically, circCD44 functions as a ceRNA that sponges miR-326 and miR-330-5p to regulate SMAD6, and its biogenesis is promoted by LRRC4 via interference with SAM68 binding on CD44 pre-mRNA and enhanced eIF4A3 enrichment."	0.8632
34631281	Molecular therapy. Nucleic acids	2021	Hsa_circ_0024093 accelerates VSMC proliferation via miR-4677-3p/miR-889-3p/USP9X/YAP1 axis in in vitro model of lower extremity ASO.	hsa_circ_0024093		hsa_circ_YAP1	YAP1	Arteriosclerosis obliterans (ASO) of the lower extremities 	MONDO:0006659	arteriosclerosis obliterans	up-regulated	RT-qPCR	"In a PDGF-BB_induced in vitro model relevant to lower-extremity ASO, hsa_circ_0024093 is upregulated and promotes VSMC proliferation and migration while inhibiting apoptosis. It functions mainly in the cytoplasm as a ceRNA that sponges miR-889-3p and miR-4677-3p to increase USP9X, which deubiquitinates and stabilizes YAP1 protein."	0.6909
34631898	Journal of immunology research	2021	circCOL1A1 Promotes the Progression of Gastric Cancer Cells through Sponging miR-145 to Enhance RABL3 Expression.	hsa_circ_0044556	circCOL1A1	hsa_circ_COL1A1	COL1A1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circCOL1A1 (hsa_circ_0044556), derived from COL1A1, is up-regulated in gastric cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes proliferation, migration and invasion, and enhances tumor growth in a cell line-derived xenograft model. Mechanistically, it sponges miR-145 to increase RABL3 expression (circCOL1A1/miR-145/RABL3 axis) and is associated with increased M2 macrophage polarization."	0.8275
34633654	Human cell	2022	F-circEA1 regulates cell proliferation and apoptosis through ALK downstream signaling pathway in non-small cell lung cancer.		F-circEA1 	hsa_circ_EML4-ALK	EML4-ALK1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	unknown	RT-qPCR	"F-circEA1 is a fusion circRNA derived from the EML4-ALK1 fusion gene in NSCLC cells. It promotes proliferation, migration/invasion and tumor growth, inhibits apoptosis, and modulates crizotinib response, at least partly by upregulating EML4-ALK1 and activating ALK downstream signaling (PI3K/AKT/mTOR, JAK3/STAT3, MEK/ERK)."	0.7633
34635009	Bioengineered	2021	Novel circular RNA circATRNL1 accelerates the osteosarcoma aerobic glycolysis through targeting miR-409-3p/LDHA.	hsa_circ_0092796	circATRNL1	hsa_circ_ATRNL1	ATRNL1	osteosarcoma	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; RNA-seq	"circATRNL1 is up-regulated in osteosarcoma tissues and cell lines and is associated with worse overall survival. It mainly localizes to the cytoplasm and promotes aerobic glycolysis and tumor progression by sponging miR-409-3p to increase LDHA expression, also reducing apoptosis; its knockdown suppresses xenograft tumor growth."	0.8429
34635012	Bioengineered	2021	Identification of circRNA_001846 as putative non-small cell lung cancer biomarker.		circRNA_001846			non_small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circRNA_001846 is up-regulated in NSCLC (tumor tissue by microarray and patient serum by RT-qPCR). High serum circRNA_001846 is associated with adverse clinicopathological features and poorer PFS/OS, and it shows good diagnostic performance for distinguishing NSCLC from healthy controls."	0.5202
34635639	Cell death discovery	2021	Exosome-transmitted circCOG2 promotes colorectal cancer progression via miR-1305/TGF-beta2/SMAD3 pathway.	hsa_circ_0016866	circCOG2	hsa_circ_COG2	COG2	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circCOG2 (hsa_circ_0016866) is up-regulated in colorectal cancer tissues/plasma/exosomes and mainly localizes to the cytoplasm. It promotes CRC proliferation, migration, invasion and EMT by sponging miR-1305 and activating the TGF-beta2/SMAD3 pathway, and can be transmitted via exosomes to enhance malignant phenotypes in recipient CRC cells; high expression predicts poor overall survival."	0.8769
34637670	Bioengineered	2021	Circular RNA circ_0090231 promotes atherosclerosis in vitro by enhancing NLR family pyrin domain containing 3-mediated pyroptosis of endothelial cells.	hsa_circ_0090231	circ_0090231			atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"In ox-LDL-treated HAECs (in vitro atherosclerosis model), circ_0090231 is up-regulated and promotes endothelial cell injury and pyroptosis. Mechanistically, it sponges miR-635 to relieve repression of NLRP3, forming a circ_0090231/miR-635/NLRP3 regulatory axis."	0.6253
34637672	Bioengineered	2021	Circular RNA circFOXP1 promotes angiogenesis by regulating microRNA -127-5p/CDKN2AIP signaling pathway in osteosarcoma.		circFOXP1 	hsa_circ_FOXP1	FOXP1	osteosarcoma	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circFOXP1 is up-regulated in osteosarcoma and promotes tumor growth and angiogenesis. Mechanistically, it competitively binds miR-127-5p to relieve repression of CDKN2AIP, forming a circFOXP1/miR-127-5p/CDKN2AIP axis. High circFOXP1 expression is associated with poorer overall survival."	0.7169
34637682	Bioengineered	2021	A novel circular RNA circ_HN1/miR-628-5p/Ecto-5'-nucleotidase competing endogenous RNA network regulates gastric cancer development.	hsa_circ_0045602	circ_HN1 	hsa_circ_HN1	HN1	gastric cancer	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_HN1 is up-regulated in gastric cancer and mainly localizes to the cytoplasm. It promotes malignant phenotypes (proliferation, spheroid formation, migration/invasion, tumor growth) and inhibits apoptosis by acting as a ceRNA that sponges miR-628-5p to upregulate NT5E."	0.8122
34641879	Cancer cell international	2021	Circular RNA hsa_circ_0002483 promotes growth and invasion of lung adenocarcinoma by sponging miR-125a-3p.	hsa_circ_0002483	circ_0002483 	hsa_circ_PTK2	PTK2	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; ISH	"hsa_circ_0002483 (circ_0002483; circPTK2) is up-regulated in LUAC and correlates with advanced TNM stage and poorer overall survival. Functionally, it promotes LUAC cell proliferation and invasion and enhances xenograft growth. Mechanistically, it sponges miR-125a-3p, relieving repression of the CCL4-CCR5 axis."	0.8711
34644734	"Clinics (Sao Paulo, Brazil)"	2021	CircularRNA_0119872 regulates the microRNA-582-3p/E2F transcription factor 3 pathway to promote the progression of malignant melanoma.	hsa_circ_0119872		hsa_circ_RASGRP3	RASGRP3	malignant melanoma 	MONDO:0005105	melanoma	up-regulated	RT-qPCR	"circ_0119872 is up-regulated in malignant melanoma tissues and cell lines and promotes proliferation, migration, and invasion. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-582-3p to increase E2F3 expression, thereby facilitating MM progression."	0.6777
34645476	World journal of surgical oncology	2021	Circ_0026416 downregulation blocks the development of colorectal cancer through depleting MYO6 expression by enriching miR-545-3p.	hsa_circ_0026416	circ_0026416			colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0026416 is up-regulated in colorectal cancer and functions as an oncogenic circRNA. Its knockdown suppresses proliferation, migration, invasion, angiogenesis and EMT while promoting apoptosis, and inhibits xenograft tumor growth, mainly by sponging miR-545-3p to relieve repression of MYO6 (circ_0026416/miR-545-3p/MYO6 axis)."	0.7949
34646424	Oxidative medicine and cellular longevity	2021	circFAM160A2 Promotes Mitochondrial Stabilization and Apoptosis Reduction in Osteoarthritis Chondrocytes by Targeting miR-505-3p and SIRT3.	hsa_circ_0020990	circFAM160A2	hsa_circ_FAM160A2	FAM160A2	osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR	"circFAM160A2 is down-regulated in osteoarthritis cartilage and acts as a ceRNA that sponges miR-505-3p to upregulate SIRT3. Its overexpression stabilizes mitochondria, reduces ROS and chondrocyte apoptosis, decreases ECM-degrading enzymes, and alleviates OA phenotypes in vitro and in an ACLT mouse model."	0.6882
34646428	Oxidative medicine and cellular longevity	2021	circAMOTL1L Suppresses Renal Cell Carcinoma Growth by Modulating the miR-92a-2-5p/KLLN Pathway.	hsa_circ_0000350	circAMOTL1L	hsa_circ_AMOTL1	Amotl1	renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	down-regulated	RT-qPCR	"circAMOTL1L is down-regulated in RCC and functions as a tumor suppressor by inhibiting proliferation and promoting apoptosis. It acts as a ceRNA sponge for miR-92a-2-5p, relieving repression of KLLN and suppressing RCC growth in vitro and in a 786-O xenograft model. Low circAMOTL1L expression is associated with advanced stage/metastasis and worse survival."	0.7353
34649564	Journal of orthopaedic surgery and research	2021	Circ_0045714/miR-331-3p interaction affects IL-1beta-evoked human articular chondrocyte injury through regulating PIK3R3 in a ceRNA regulatory cascade.	hsa_circ_0045714	circ_0045714	hsa_circ_UNK	UNK	Osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR	"circ_0045714 is down-regulated in OA knee cartilage/chondrocytes and in IL-1beta-treated human articular chondrocytes. Its overexpression protects chondrocytes by sponging miR-331-3p to up-regulate PIK3R3, thereby attenuating IL-1beta-induced apoptosis, inflammation, and matrix degradation and improving proliferation/ECM synthesis, linked to PI3K/AKT signaling."	0.7591
34649567	Molecular cancer	2021	Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signaling.	hsa_circ_0007915	circIPO11	hsa_circ_IPO11	IPO11	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Northern Blot; Microarray	"circIPO11 is up-regulated in HCC tumor tissues and liver CSCs and is required for CSC self-renewal and tumor initiation/propagation. Mechanistically, it binds TOP1 and recruits it to the GLI1 promoter to activate GLI1 transcription, thereby promoting Hedgehog signaling."	0.8283
34649611	Journal of ovarian research	2021	Circ_0061140 knockdown inhibits tumorigenesis and improves PTX sensitivity by regulating miR-136/CBX2 axis in ovarian cancer.	hsa_circ_0061140	circular_0061140 	hsa_circ_C20orf11	C20orf11	ovarian cancer	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circ_0061140 is up-regulated in PTX-resistant ovarian cancer tissues/cells and promotes malignant phenotypes and paclitaxel resistance. Mechanistically, it sponges miR-136 to increase CBX2, thereby reducing PTX sensitivity; its knockdown suppresses tumor growth and enhances PTX response in vivo."	0.6287
34650036	Cell death & disease	2021	CircNPHP4 in monocyte-derived small extracellular vesicles controls heterogeneous adhesion in coronary heart atherosclerotic disease.	hsa_circ_0009135	circNPHP4	hsa_circ_NPHP4	NPHP4	coronary heart atherosclerotic disease 	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR; Microarray	"In CAD, circNPHP4 is upregulated in monocyte-derived sEVs and in serum, and it promotes heterogeneous adhesion between monocytes and coronary artery endothelial cells. Mechanistically, circNPHP4 functions as a ceRNA sponge for miR-1231, derepressing EGFR and activating EGFR/PI3K/AKT (and downstream NF-kappaB-related adhesion molecule expression such as ICAM-1 and VCAM-1). Clinically, elevated circNPHP4 shows diagnostic/risk-prediction value for CAD (ROC/nomogram)."	0.8933
34650925	Frontiers in oncology	2021	Chronic Stress-Induced Gene Changes In Vitro and In Vivo: Potential Biomarkers Associated With Depression and Cancer Based on circRNA- and lncRNA-Associated ceRNA Networks.	hsa_circ_0087100		hsa_circ_CNTNAP3	CNTNAP3	depression	MONDO:0002050	depressive disorder	dysregulated	RT-qPCR; Microarray	"hsa_circ_0087100 (from CNTNAP3) is dysregulated in depression and is induced by stress hormones (cortisol or norepinephrine) in multiple cancer cell lines, suggesting a stress-responsive circRNA potentially linking depression-related stress to cancer-associated transcriptional changes."	0.4997
34650925	Frontiers in oncology	2021	Chronic Stress-Induced Gene Changes In Vitro and In Vivo: Potential Biomarkers Associated With Depression and Cancer Based on circRNA- and lncRNA-Associated ceRNA Networks.	hsa_circ_0014221		hsa_circ_S100A9	S100A9	depression	MONDO:0002050	depressive disorder	unknown	RT-qPCR	"hsa_circ_0014221 (from S100A9) is induced by stress hormones (cortisol or norepinephrine) in multiple cancer cell lines, and is discussed as being enriched in the IL-17 signaling pathway together with its host gene S100A9 in the context of depression-related inflammation and depression_cancer links."	0.31
34650925	Frontiers in oncology	2021	Chronic Stress-Induced Gene Changes In Vitro and In Vivo: Potential Biomarkers Associated With Depression and Cancer Based on circRNA- and lncRNA-Associated ceRNA Networks.	hsa_circ_0014220		hsa_circ_S100A9	S100A9	depression	MONDO:0002050	depressive disorder	unknown	RT-qPCR	hsa_circ_0014220 (from S100A9) is induced by stress hormones (cortisol or norepinephrine) in multiple cancer cell lines and is discussed as an IL-17-pathway_enriched inflammatory circRNA potentially connecting depression-associated inflammation with cancer-related processes.	0.31
34652255	Bioengineered	2021	Circular RNA hsa_circ_0005567 overexpression promotes M2 type macrophage polarization through miR-492/SOCS2 axis to inhibit osteoarthritis progression.	hsa_circ_0005567				osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR	"hsa_circ_0005567 is downregulated in osteoarthritis synovial tissues. Its overexpression sponges miR-492 to upregulate SOCS2, shifting THP-1 macrophages away from M1 and toward M2 polarization, which indirectly improves chondrocyte viability and reduces apoptosis, thereby inhibiting osteoarthritis progression."	0.6996
34654357	Bioengineered	2021	Circular RNA FOXP1 relieves trophoblastic cell dysfunction in recurrent pregnancy loss via the miR-143-3p/S100A11 cascade.		circFOXP1 	hsa_circ_FOXP1	FOXP1	recurrent pregnancy loss 	MONDO:0005047	infertility disorder	down-regulated	RT-qPCR	"circFOXP1 is down-regulated in RPL placental tissues. It alleviates trophoblastic cell dysfunction by acting as a miR_143_3p sponge to upregulate S100A11, thereby promoting proliferation/viability, EMT, migration and invasion, and inhibiting apoptosis."	0.6536
34658165	Thoracic cancer	2021	Circ_0016760 accelerates non-small-cell lung cancer progression through miR-646/AKT3 signaling in vivo and in vitro.	hsa_circ_0016760		hsa_circ_SNAP47	SNAP47	non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0016760 is up-regulated in NSCLC tissues and cell lines and functions as an oncogenic circRNA. It mainly localizes to the cytoplasm and promotes NSCLC proliferation, migration/invasion and tumor growth while inhibiting apoptosis by sponging miR-646 to upregulate AKT3 (circ_0016760/miR-646/AKT3 axis)."	0.7855
34659329	Frontiers in genetics	2021	"CircC6orf132 Facilitates Proliferation, Migration, Invasion, and Glycolysis of Gastric Cancer Cells Under Hypoxia by Acting on the miR-873-5p/PRKAA1 Axis."	hsa_circ_0092341		hsa_circ_C6orf132	C6orf132	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circC6orf132 is up-regulated in gastric cancer tissues/cells and further induced by hypoxia. It mainly localizes to the cytoplasm and promotes hypoxia-associated malignant phenotypes (proliferation, migration, invasion) and glycolysis by sponging miR-873-5p, thereby increasing PRKAA1 expression; knockdown suppresses xenograft tumor growth and glycolysis."	0.8025
34659347	Frontiers in genetics	2021	CircSETD3 (Hsa_circ_0000567) Suppresses Hepatoblastoma Pathogenesis via Targeting the miR-423-3p/Bcl-2-Interacting Mediator of Cell Death Axis.	hsa_circ_0000567	circSETD3	hsa_circ_SETD3	SETD3	hepatoblastoma 	MONDO:0018666	hepatoblastoma	down-regulated	RT-qPCR	"circSETD3 is down-regulated in hepatoblastoma and acts as a tumor suppressor. It mainly localizes to the cytoplasm and inhibits HB cell proliferation/migration/EMT while promoting apoptosis by sponging miR-423-3p to upregulate the pro-apoptotic target Bim, suppressing tumor growth in a cell line-derived xenograft model."	0.8464
34659544	Journal of Cancer	2021	Circular RNA hsa_circ_0001306 Functions as a Competing Endogenous RNA to Regulate FBXW7 Expression by Sponging miR-527 in Hepatocellular Carcinoma.	hsa_circ_0001306		hsa_circ_RAD54L2	RAD54L2	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001306 is down-regulated in hepatocellular carcinoma and functions as a tumor suppressor. It mainly acts as a ceRNA that sponges miR-527 to relieve repression of FBXW7, thereby inhibiting HCC proliferation, invasion and cell-cycle progression; knockdown enhances xenograft tumor growth."	0.8256
34659556	Journal of Cancer	2021	Circular RNA Hsa_circRNA_101996 promotes the development of Gastric Cancer via Upregulating Matrix Metalloproteinases-2/Matrix Metalloproteinases-9 through MicroRNA-143/Ten-eleven translocation-2 Pathway.		hsa_circRNA_101996 			gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"hsa_circRNA_101996 is up-regulated in gastric cancer tissues/cell lines and mainly localizes to the cytoplasm. It promotes GC proliferation, migration, invasion and in vivo tumor growth by sponging miR-143, thereby de-repressing TET2 and increasing MMP2/MMP9 expression via a DNA demethylation-related mechanism; high expression indicates worse survival."	0.7444
34660182	Analytical cellular pathology (Amsterdam)	2021	circ-SIRT1 Promotes Colorectal Cancer Proliferation and EMT by Recruiting and Binding to eIF4A3.		circ-SIRT1	hsa_circ_SIRT1	SIRT1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ-SIRT1 is up-regulated in colorectal cancer tissues and cell lines and correlates with deeper tumor invasion. Functionally, circ-SIRT1 promotes CRC cell proliferation, migration/invasion and EMT by binding EIF4A3 and reducing EIF4A3 recruitment to N-cadherin and vimentin mRNAs, thereby increasing EMT marker expression."	0.6825
34660257	Frontiers in oncology	2021	CircNRIP1 Encapsulated by Bone Marrow Mesenchymal Stem Cell-Derived Extracellular Vesicles Aggravates Osteosarcoma by Modulating the miR-532-3p/AKT3/PI3K/AKT Axis.	hsa_circ_0004771	circNRIP1	hsa_circ_NRIP1	NRIP1	osteosarcoma	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"In osteosarcoma, circNRIP1 is up-regulated and promotes malignant phenotypes (proliferation, migration, invasion) and tumor growth. It is delivered by BMSC-derived extracellular vesicles and functions as a sponge for miR-532-3p, thereby de-repressing AKT3 and activating the PI3K/AKT pathway."	0.7283
34663267	BMC pulmonary medicine	2021	Circular RNA NEK6 contributes to the development of non-small-cell lung cancer by competitively binding with miR-382-5p to elevate BCAS2 expression at post-transcriptional level.		circ_NEK6 	hsa_circ_NEK6	NEK6	non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_NEK6 is up-regulated in NSCLC tissues and cell lines and functions as an oncogenic circRNA. It mainly localizes to the cytoplasm and promotes proliferation, migration and invasion while inhibiting apoptosis by sponging miR-382-5p to de-repress BCAS2 (circ_NEK6/miR-382-5p/BCAS2 axis)."	0.8487
34663837	Scientific reports	2021	Deregulation of hsa_circ_0001971/miR-186 and hsa_circ_0001874/miR-296 signaling pathways promotes the proliferation of oral squamous carcinoma cells by synergistically activating SHP2/PLK1 signals.	hsa_circ_0001874	circ_0001874			oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	dysregulated	RT-qPCR	"In OSCC, hsa_circ_0001874 acts as an oncogenic circRNA that promotes proliferation and suppresses apoptosis. Mechanistically, it functions in a ceRNA axis by interacting with miR-296-5p and regulating the downstream target PLK1, and it may have predictive biomarker potential."	0.7129
34663837	Scientific reports	2021	Deregulation of hsa_circ_0001971/miR-186 and hsa_circ_0001874/miR-296 signaling pathways promotes the proliferation of oral squamous carcinoma cells by synergistically activating SHP2/PLK1 signals.	hsa_circ_0001971	circ_0001971			oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	dysregulated	RT-qPCR	"In OSCC, hsa_circ_0001971 exerts oncogenic effects by promoting proliferation and suppressing apoptosis. It functions through a ceRNA mechanism involving miR-186 and the downstream target SHP2, and may also influence PLK1 via pathway cross-talk; it is proposed as a predictive biomarker candidate."	0.7129
34664684	Molecular medicine reports	2021	Circular RNA hsa_circ_105039 promotes cardiomyocyte differentiation by sponging miR_17 to regulate cyclinD2 expression.		hsa_circ_105039 			congenital heart disease 	MONDO:0005453	congenital heart disease	down-regulated	RT-qPCR	"hsa_circ_105039 is downregulated in CHD heart tissue and, in a DMSO-induced iPS cardiomyocyte model, its overexpression promotes cardiomyocyte differentiation, viability and migration while inhibiting apoptosis. Mechanistically, it sponges miR-17 to derepress cyclinD2, forming a hsa_circ_105039/miR-17/cyclinD2 regulatory axis with potential diagnostic relevance for CHD."	0.5607
34664737	Journal of clinical laboratory analysis	2021	Hsa_circ_0001806 promotes glycolysis and cell progression in hepatocellular carcinoma through miR-125b/HK2.	hsa_circ_0001806	Circ_0001806	hsa_circ_CSPP1	CSPP1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"hsa_circ_0001806 is up-regulated in HCC and associated with advanced disease and poor overall survival. Functionally it promotes proliferation, migration and glycolysis and inhibits apoptosis. Mechanistically it sponges miR-125b to increase HK2 expression, forming a miR-125b/HK2 axis that mediates these malignant phenotypes."	0.7646
34664835	Medicine	2021	Hsa_circ_0074491 regulates the malignance of cholesteatoma keratinocytes by modulating the PI3K/Akt pathway by binding to miR-22-3p and miR-125a-5p: An observational study.	hsa_circ_0074491	circ_0074491	hsa_circ_PPARGC1B	PPARGC1B	cholesteatoma	MONDO:0006530	cholesteatoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0074491 (circ_0074491), derived from PPARGC1B, is down-regulated in cholesteatoma tissues. Functionally, circ_0074491 suppresses cholesteatoma keratinocyte proliferation/migration/invasion and promotes apoptosis by sponging miR-22-3p and miR-125a-5p, thereby inhibiting PI3K/AKT signaling."	0.73
34666800	Journal of experimental & clinical cancer research : CR	2021	CircGSK3B promotes RORA expression and suppresses gastric cancer progression through the prevention of EZH2 trans-inhibition.	hsa_circ_0003763	circGSK3B 	hsa_circ_GSK3B	GSK3B	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"circGSK3B (hsa_circ_0003763) is down-regulated in gastric cancer tissues and cell lines and functions as a tumor suppressor. It localizes mainly in the nucleus and directly binds EZH2, reducing EZH2/H3K27me3 repression at the RORA promoter to increase RORA expression, thereby inhibiting Wnt/beta-catenin-related malignant phenotypes (proliferation, invasion/migration, metastasis) and promoting apoptosis."	0.8568
34668628	Journal of cellular and molecular medicine	2021	CircGFRA1 facilitates the malignant progression of HER-2-positive breast cancer via acting as a sponge of miR-1228 and enhancing AIFM2 expression.		hsa_circ_005239 	hsa_circ_GFRA1	GFRA1	HER_2_positive breast cancer 	MONDO:0006244	HER2 positive breast carcinoma	up-regulated	RT-qPCR; Microarray	"circGFRA1 (hsa_circ_005239), derived from the GFRA1 gene, is up-regulated in HER-2-positive breast cancer cells and tissues. It promotes malignant behaviors (proliferation, invasion and metastasis) and inhibits ferroptosis by sponging miR-1228 to enhance AIFM2 expression (circGFRA1/miR-1228/AIFM2 ceRNA axis)."	0.8069
34670246	Chinese medical journal	2021	Circular RNAs in peripheral blood mononuclear cells from ankylosing spondylitis.	hsa_circ_0001544	hsa_circRNA_001544	hsa_circ_NR3C1	NR3C1	ankylosing spondylitis 	MONDO:0005306	ankylosing spondylitis	up-regulated	RT-qPCR; Microarray	hsa_circRNA_001544 (hsa_circ_0001544; host gene NR3C1) is up-regulated in PBMCs from AS patients and shows diagnostic potential based on ROC analysis.	0.5047
34670246	Chinese medical journal	2021	Circular RNAs in peripheral blood mononuclear cells from ankylosing spondylitis.	hsa_circ_0008813	hsa_circRNA_102532	hsa_circ_UBA2	UBA2	ankylosing spondylitis 	MONDO:0005306	ankylosing spondylitis	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_102532 (hsa_circ_0008813; host gene UBA2) is up-regulated in PBMCs from AS patients, has predicted miRNA-sponging interactions, and shows modest diagnostic potential by ROC analysis."	0.5047
34670246	Chinese medical journal	2021	Circular RNAs in peripheral blood mononuclear cells from ankylosing spondylitis.	hsa_circ_0008961	hsa_circRNA_008961	hsa_circ_NAB1	NAB1	ankylosing spondylitis 	MONDO:0005306	ankylosing spondylitis	up-regulated	RT-qPCR; Microarray	hsa_circRNA_008961 (hsa_circ_0008961; host gene NAB1) is increased in active AS versus healthy controls and is linked to disease activity via its negative correlation with PLT count.	0.4032
34670246	Chinese medical journal	2021	Circular RNAs in peripheral blood mononuclear cells from ankylosing spondylitis.	hsa_circ_0012732	hsa_circRNA_012732	hsa_circ_MYSM1	MYSM1	ankylosing spondylitis 	MONDO:0005306	ankylosing spondylitis	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_012732 (hsa_circ_0012732; host gene MYSM1) is lower in active AS than stable AS, correlates with multiple clinical inflammation/activity indicators, and is proposed as a disease-activity indicator and potential therapeutic target."	0.4032
34670409	"Arteriosclerosis, thrombosis, and vascular biology"	2021	CircSOD2: A Novel Regulator for Smooth Muscle Proliferation and Neointima Formation.		circSOD2	hsa_circ_SOD2	SOD2	vascular injury-induced neointima formation 	MONDO:0005385	vascular disorder	up-regulated	RT-qPCR; RNA-seq	"circSOD2 is induced during vascular injury/PDGF-BB stimulation and promotes smooth muscle cell proliferation and neointima formation. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-206, relieving repression of NOTCH3 to activate NOTCH3 signaling (including ERK/p38/HEY1) and drive Cyclin D1/CDK4/6-dependent G1-to-S cell cycle progression."	0.7992
34675680	Cancer management and research	2021	Circular RNA Circ-0003006 Promotes Hepatocellular Carcinoma Proliferation and Metastasis Through Sponging miR-542-3p and Regulating HIF-1A.	hsa_circ_0003006		hsa_circ_FLNB	FLNB	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ-0003006 is up-regulated in hepatocellular carcinoma and mainly localized in the cytoplasm. It promotes HCC proliferation and metastasis by sponging miR-542-3p to increase HIF-1A expression, and its expression correlates with adverse clinicopathological features and poor prognosis."	0.8251
34675997	Experimental and therapeutic medicine	2021	Overexpression of circAtp9b in ulcerative colitis is induced by lipopolysaccharides and upregulates PTEN to promote the apoptosis of colonic epithelial cells.		circAtp9b 	hsa_circ_ATP9B	Atp9b	ulcerative colitis 	MONDO:0005101	ulcerative colitis	up-regulated	RT-qPCR	"circAtp9b is up-regulated in ulcerative colitis patient plasma and is inducible by LPS in human colonic epithelial cells. Functionally, circAtp9b promotes LPS-induced apoptosis by acting upstream to increase PTEN expression; PTEN overexpression partially rescues the anti-apoptotic effect of circAtp9b knockdown."	0.5214
34676300	Open life sciences	2021	"circ_CHFR regulates ox-LDL-mediated cell proliferation, apoptosis, and EndoMT by miR-15a-5p/EGFR axis in human brain microvessel endothelial cells."		circ_CHFR 	hsa_circ_CHFR	CHFR	ox-LDL-induced human brain vascular diseases 	MONDO:0004995	cardiovascular disorder	up-regulated	RT-qPCR	"circ_CHFR is up-regulated in ox-LDL-treated HBMECs and aggravates ox-LDL-induced dysfunction by sponging miR-15a-5p, thereby relieving miR-15a-5p-mediated repression of EGFR. Silencing circ_CHFR lowers EGFR and counteracts ox-LDL effects on proliferation, cell-cycle arrest, apoptosis, and EndoMT."	0.6945
34676904	Journal of clinical laboratory analysis	2021	circCORO1C promotes the proliferation and metastasis of hepatocellular carcinoma by enhancing the expression of PD-L1 through NF-kappaB pathway.	hsa_circ_0006852		hsa_circ_CORO1C	CORO1C	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circCORO1C is up-regulated in HCC tissues and promotes HCC cell proliferation, migration/invasion and xenograft tumor growth. It enhances PD-L1 expression by activating NF-kappaB signaling, increasing p65 phosphorylation and upregulating c-Myc and COX-2."	0.6502
34680287	Cancers	2021	Circular RNAs in Hedgehog Signaling Activation and Hedgehog-Mediated Medulloblastoma Tumors.	hsa_circ_0000915		hsa_circ_FKBP8	FKBP8	medulloblastoma 	MONDO:0007959	medulloblastoma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0000915 (FKBP8 circRNA) is down-regulated in SHH-subtype medulloblastoma compared with normal cerebellum while its corresponding linear mRNA is unchanged. Functional perturbation (siRNA knockdown or overexpression) shows minimal effects on proliferation in medulloblastoma cell lines.	0.7059
34680287	Cancers	2021	Circular RNAs in Hedgehog Signaling Activation and Hedgehog-Mediated Medulloblastoma Tumors.	hsa_circ_0001445		hsa_circ_SMARCA5	SMARCA5	medulloblastoma 	MONDO:0007959	medulloblastoma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0001445 (SMARCA5 circRNA) is down-regulated in SHH-subtype medulloblastoma compared with normal cerebellum while its corresponding linear mRNA is unchanged. Knockdown/overexpression experiments indicate minimal effects on proliferation in Daoy and UW-228 cells.	0.7059
34680287	Cancers	2021	Circular RNAs in Hedgehog Signaling Activation and Hedgehog-Mediated Medulloblastoma Tumors.	hsa_circ_0002079		hsa_circ_GLIS1	GLIS1	medulloblastoma 	MONDO:0007959	medulloblastoma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0002079 (GLIS1 circRNA) is down-regulated in SHH-subtype medulloblastoma relative to cerebellum while its linear mRNA does not change. Loss- and gain-of-function experiments show minimal impact on proliferation in medulloblastoma cell lines.	0.7059
34680287	Cancers	2021	Circular RNAs in Hedgehog Signaling Activation and Hedgehog-Mediated Medulloblastoma Tumors.	hsa_circ_0001181		hsa_circ_BACH1	BACH1	medulloblastoma 	MONDO:0007959	medulloblastoma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0001181 (BACH1 circRNA) is down-regulated in SHH-subtype medulloblastoma versus cerebellum while the linear BACH1 mRNA is unchanged. Knockdown or overexpression does not significantly alter proliferation in Daoy and UW-228 cells.	0.7059
34680287	Cancers	2021	Circular RNAs in Hedgehog Signaling Activation and Hedgehog-Mediated Medulloblastoma Tumors.	hsa_circ_0001727		hsa_circ_ZKSCAN1	ZKSCAN1	medulloblastoma 	MONDO:0007959	medulloblastoma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0001727 (ZKSCAN1 circRNA) is down-regulated in SHH-subtype medulloblastoma versus cerebellum while the linear transcript remains unchanged. Functional assays after knockdown/overexpression show minimal effects on medulloblastoma cell proliferation.	0.7059
34680287	Cancers	2021	Circular RNAs in Hedgehog Signaling Activation and Hedgehog-Mediated Medulloblastoma Tumors.	hsa_circ_0008285		hsa_circ_CDYL	CDYL	medulloblastoma 	MONDO:0007959	medulloblastoma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0008285 (CDYL circRNA) is down-regulated in SHH-subtype medulloblastoma compared with cerebellum while linear CDYL mRNA is unchanged. Knockdown and overexpression experiments show minimal effects on proliferation in medulloblastoma cell lines.	0.7059
34680287	Cancers	2021	Circular RNAs in Hedgehog Signaling Activation and Hedgehog-Mediated Medulloblastoma Tumors.	hsa_circ_0003340		hsa_circ_OGDH	OGDH	medulloblastoma 	MONDO:0007959	medulloblastoma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0003340 (OGDH circRNA) is down-regulated in SHH-subtype medulloblastoma compared with cerebellum while its linear mRNA does not change. siRNA depletion and plasmid overexpression experiments show minimal impact on medulloblastoma cell proliferation.	0.7059
34685466	"Life (Basel, Switzerland)"	2021	Comprehensive Characterization of Androgen-Responsive circRNAs in Prostate Cancer.	hsa_circ_0012755		hsa_circ_NFIA	NFIA	prostate cancer	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	"circNFIA is up-regulated in prostate cancer tissues, cell lines, and patient plasma. Functional knockdown suggests it promotes proliferation and cell-cycle progression while suppressing apoptosis. A bioinformatically predicted ceRNA network indicates potential involvement of PI3K-Akt and MAPK signaling via circRNA_miRNA_mRNA regulation."	0.6046
34685466	"Life (Basel, Switzerland)"	2021	Comprehensive Characterization of Androgen-Responsive circRNAs in Prostate Cancer.	hsa_circ_0049154		hsa_circ_ZNF561	ZNF561	prostate cancer	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR	"circZNF561 is down-regulated in prostate cancer tissues, cell lines, and patient plasma. Knockdown experiments indicate it restrains proliferation and cell-cycle progression and supports apoptosis, consistent with a tumor-suppressive role. A predicted ceRNA network suggests potential links to PI3K-Akt/MAPK signaling and ubiquitination-related processes."	0.568
34686662	Cell death & disease	2021	Circular RNA circUBE2J2 acts as the sponge of microRNA-370-5P to suppress hepatocellular carcinoma progression.	hsa_circ_0009246	circUBE2J2	hsa_circ_UBE2J2	UBE2J2	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; ISH; Microarray	"circUBE2J2 (hsa_circ_0009246) is down-regulated in HCC and functions as a tumor suppressor. It mainly localizes to the cytoplasm and acts as a ceRNA by sponging miR-370-5P, thereby relieving repression of KLF7 to inhibit HCC cell proliferation and migration and suppress xenograft tumor growth. Low circUBE2J2 expression is associated with poorer overall survival."	0.8901
34689155	Cell death discovery	2021	Doxorubicin-induced novel circRNA_0004674 facilitates osteosarcoma progression and chemoresistance by upregulating MCL1 through miR-142-5p.	hsa_circ_0004674		hsa_circ_ADAM22	ADAM22	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; RNA-seq	"circ_0004674 (hsa_circ_0004674), derived from ADAM22, is upregulated in chemoresistant osteosarcoma tissues/cell lines and is associated with poor survival. It promotes OS progression and doxorubicin resistance by acting as a cytoplasmic ceRNA that sponges miR-142-5p, thereby relieving repression of MCL1 and increasing its expression."	0.8921
34689806	Journal of translational medicine	2021	Bioinformatics analysis reveals a stem cell-expressed circ-Serpine2-mediated miRNA-mRNA regulatory subnetwork in the malignant progression of glioma.		circ-Serpine2 	hsa_circ_SERPINE2	Serpine2	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR; RNA-seq; Microarray	"circ-Serpine2 is upregulated in GSC23-derived exosomal context and acts predominantly in the cytoplasm as a ceRNA. It sponges miR-124-3p to increase KIF20A, thereby promoting glioma cell proliferation/migration/invasion and inhibiting apoptosis, and it enhances tumor growth in a xenograft model."	0.5318
34689819	Diagnostic pathology	2021	CircRNA NRIP1 promotes papillary thyroid carcinoma progression by sponging mir-195-5p and modulating the P38 MAPK and JAK/STAT pathways.		CircRNA NRIP1 	hsa_circ_NRIP1	NRIP1	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"CircRNA NRIP1 is up-regulated in papillary thyroid carcinoma tissues and cell lines and is associated with advanced stage. It promotes PTC cell proliferation and invasion and inhibits apoptosis by sponging miR-195-5p, thereby activating P38 MAPK and JAK/STAT signaling (increased p-p38, p-JAK2, p-STAT1) and enhancing xenograft tumor growth."	0.8001
34691176	Journal of oncology	2021	CircPTK2 (hsa_circ_0003221) Contributes to Laryngeal Squamous Cell Carcinoma by the miR-1278/YAP1 Axis.	hsa_circ_0003221	CircPTK2	hsa_circ_PTK2	PTK2	laryngeal squamous cell carcinoma 	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR	"circPTK2 (hsa_circ_0003221), derived from PTK2, is up-regulated in LSCC tissues and cell lines and is associated with advanced clinical stage and lymph-node metastasis. Functionally, circPTK2 promotes proliferation/cell-cycle progression and suppresses apoptosis, and its knockdown inhibits xenograft tumor growth. Mechanistically, circPTK2 acts as a ceRNA sponging miR-1278 to upregulate YAP1 in LSCC cells."	0.8405
34692507	Frontiers in oncology	2021	Circular RNA Circ-0002570 Accelerates Cancer Progression by Regulating VCAN via MiR-587 in Gastric Cancer.	hsa_circ_0002570		hsa_circ_FAM73A	FAM73A	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; ISH; Microarray	"Circ-0002570 (hsa_circ_0002570), derived from FAM73A, is up-regulated in gastric cancer tissues and cell lines and predicts poor survival. It promotes proliferation, migration, invasion, and tumor growth by sponging miR-587 to de-repress VCAN, forming a circ-0002570/miR-587/VCAN ceRNA axis."	0.8847
34693745	Cell transplantation	2021	CircRFWD2 Promotes Osteogenic Differentiation of human Dental Pulp Stem Cells by Targeting miR-6817-5p Through BMP-Smad and p38 MAPK Pathway.		circRFWD2	hsa_circ_RFWD2	RFWD2	bone defects	MONDO:0005381	bone disorder	up-regulated	RT-qPCR	"circRFWD2 is up-regulated during osteogenic induction of human dental pulp stem cells and promotes osteogenic differentiation. It functions as a ceRNA by binding miR-6817-5p, thereby increasing BMPR2 levels and activating Smad5 and p38 phosphorylation (BMP-Smad and p38 MAPK signaling) to enhance osteogenesis."	0.6099
34695805	Aging	2021	Circular RNA circPRKCI contributes to malignant progression of T-cell acute lymphoblastic leukemia by modulating miR-20a-5p/SOX4 axis.		circPRKCI	hsa_circ_PRKCI	PRKCI	T-cell acute lymphoblastic leukemia 	MONDO:0004963	T-cell acute lymphoblastic leukemia	up-regulated	RT-qPCR	"circPRKCI is up-regulated in clinical T-ALL bone marrow samples and promotes T-ALL cell survival. Mechanistically, circPRKCI functions as a ceRNA sponging miR-20a-5p, thereby relieving miR-20a-5p_mediated repression of SOX4 and reducing apoptosis."	0.6479
34696782	Journal of experimental & clinical cancer research : CR	2021	Hsa_circ_0004296 inhibits metastasis of prostate cancer by interacting with EIF4A3 to prevent nuclear export of ETS1 mRNA.	hsa_circ_0004296		hsa_circ_ETS1	ETS1	prostate cancer 	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; RNA-seq	"In prostate cancer, circ_0004296 is down-regulated in tumor tissues and also decreased in patients' plasma and urine, correlating negatively with metastasis. Functionally, it suppresses proliferation, migration/invasion, EMT and metastasis. Mechanistically, it is mainly nuclear and binds EIF4A3 to retain EIF4A3 in the nucleus, thereby blocking nuclear export of ETS1 mRNA and reducing ETS1 protein expression."	0.872
34696797	Molecular cancer	2021	CircCD44 plays oncogenic roles in triple-negative breast cancer by modulating the miR-502-5p/KRAS and IGF2BP2/Myc axes.	hsa_circ_0021735	circCD44 	hsa_circ_CD44	CD44	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; RNA-seq	"circCD44 is up-regulated in TNBC and predicts worse prognosis. It promotes malignant phenotypes (proliferation, migration/invasion, tumorigenesis/metastasis and chemoresistance) by sponging miR-502_5p to increase KRAS signaling and by binding IGF2BP2 to enhance m6A-associated stabilization of Myc mRNA."	0.898
34698000	Bioengineered	2021	"Circular RNA CNOT2 knockdown regulates twist family BHLH transcription factor via targeting microRNA 409-3p to prevent breast cancer invasion, migration and epithelial-mesenchymal transition."		circCNOT2 	hsa_circ_CNOT2	CNOT2	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circCNOT2 is up-regulated in breast cancer tissues/cells and correlates with worse survival. Functionally, circCNOT2 promotes proliferation, invasion, migration and EMT while inhibiting apoptosis in BC cells. Mechanistically, circCNOT2 acts as a ceRNA sponging miR-409-3p to increase TWIST1 expression (circCNOT2/miR-409-3p/TWIST1 axis)."	0.7537
34699255	Cell transplantation	2021	Identifying Circular RNAs in HepG2 Expressing Genotype IV Swine Hepatitis E Virus ORF3 Via Whole Genome Sequencing.	hsa_circ_0001423				swine hepatitis E 	MONDO:0024990	swine disease	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001423 was up-regulated in HepG2 cells upon adenovirus-mediated overexpression of genotype IV SHEV ORF3 compared with control (Ad_GFP). The study profiled circRNAs and validated this differential expression by RT-qPCR, without establishing a specific downstream mechanism for this circRNA."	0.1904
34699255	Cell transplantation	2021	Identifying Circular RNAs in HepG2 Expressing Genotype IV Swine Hepatitis E Virus ORF3 Via Whole Genome Sequencing.	hsa_circ_0006404				swine hepatitis E 	MONDO:0024990	swine disease	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0006404 was up-regulated in HepG2 cells upon adenovirus-mediated overexpression of genotype IV SHEV ORF3 compared with control (Ad_GFP). This differential expression was supported by sequencing and confirmed by RT-qPCR, but no specific downstream targets or mechanisms were experimentally validated for this circRNA."	0.1904
34699255	Cell transplantation	2021	Identifying Circular RNAs in HepG2 Expressing Genotype IV Swine Hepatitis E Virus ORF3 Via Whole Genome Sequencing.	hsa_circ_0004833				swine hepatitis E 	MONDO:0024990	swine disease	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0004833 was down-regulated in HepG2 cells following ORF3 overexpression (Ad_ORF3 vs Ad_GFP). The study identified this change by RNA-seq and confirmed it by RT-qPCR, without providing a validated miRNA/target or functional phenotype for this circRNA."	0.1904
34699255	Cell transplantation	2021	Identifying Circular RNAs in HepG2 Expressing Genotype IV Swine Hepatitis E Virus ORF3 Via Whole Genome Sequencing.	hsa_circ_0007444				swine hepatitis E 	MONDO:0024990	swine disease	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0007444 was down-regulated in HepG2 cells after ORF3 overexpression (Ad_ORF3 vs Ad_GFP). The study provided sequencing-based profiling and RT-qPCR confirmation, but did not experimentally validate an interaction network or biological phenotype for this circRNA."	0.1904
34699307	Virulence	2021	Sweeping analysis of transcript profile in dengue virus serotype 3 infection and antibody-dependent enhancement of infection.		novel_circ_001562 			dengue virus serotype 3 infection 	MONDO:0005502	dengue disease	dysregulated	RT-qPCR; RNA-seq	"novel_circ_001562 is differentially expressed in THP-1 cells under DENV-3 infection and ADE conditions. It is predicted to encode a small peptide whose amino acid sequence is consistent/highly similar to DDX60L, suggesting a potential interferon-stimulated antiviral role in DENV-host interactions."	0.4761
34699307	Virulence	2021	Sweeping analysis of transcript profile in dengue virus serotype 3 infection and antibody-dependent enhancement of infection.		hsa_circ_001812			dengue virus serotype 3 infection 	MONDO:0005502	dengue disease	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_001812 is a differentially expressed circRNA in DENV-3 infection and/or ADE models in THP-1 cells. It was analyzed for ORF/IRES features and was predicted to have small-peptide encoding potential, suggesting a possible role in host immune response during DENV-host interactions."	0.4761
34699307	Virulence	2021	Sweeping analysis of transcript profile in dengue virus serotype 3 infection and antibody-dependent enhancement of infection.	hsa_circ_0003915				dengue virus serotype 3 infection 	MONDO:0005502	dengue disease	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0003915 is a differentially expressed circRNA in DENV-3 infection/ADE models in THP-1 cells. It was analyzed for ORF/IRES and predicted to have small-peptide encoding potential, suggesting a possible contribution to host immune-related responses in DENV-host interactions."	0.4761
34699307	Virulence	2021	Sweeping analysis of transcript profile in dengue virus serotype 3 infection and antibody-dependent enhancement of infection.		hsa_circ_001801			dengue virus serotype 3 infection 	MONDO:0005502	dengue disease	dysregulated	RT-qPCR; RNA-seq	hsa_circ_001801 is a differentially expressed circRNA in DENV-3 infection/ADE models in THP-1 cells. ORF/IRES prediction suggests it may encode a small peptide and potentially participate in immune-related DENV-host interactions.	0.4761
34699307	Virulence	2021	Sweeping analysis of transcript profile in dengue virus serotype 3 infection and antibody-dependent enhancement of infection.	hsa_circ_0002983				dengue virus serotype 3 infection 	MONDO:0005502	dengue disease	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0002983 is a differentially expressed circRNA in THP-1 DENV-3 infection/ADE comparisons. Unlike the other highlighted circRNAs, it was predicted not to encode small peptides; no specific ceRNA axis was reported for it."	0.4761
34699307	Virulence	2021	Sweeping analysis of transcript profile in dengue virus serotype 3 infection and antibody-dependent enhancement of infection.	hsa_circ_0007052				dengue virus serotype 3 infection 	MONDO:0005502	dengue disease	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0007052 is differentially expressed in THP-1 cells across DENV-3 infection/ADE comparisons. The study proposes a ceRNA axis where hsa_circ_0007052 sponges hsa-let-7 c-5p, potentially derepressing mRNAs such as CD200R1, CASP3 and SUGT1; it was also included among circRNAs with predicted peptide-coding potential."	0.4761
34702297	Molecular cancer	2021	"CircRNF220, not its linear cognate gene RNF220, regulates cell growth and is associated with relapse in pediatric acute myeloid leukemia."	hsa_circ_0012152	circRNF220	hsa_circ_RNF220	RNF220	pediatric acute myeloid leukemia 	MONDO:0004996	childhood acute myeloid leukemia	up-regulated	RT-qPCR; Microarray	"circRNF220 is up-regulated in pediatric AML (BM and PB) and serves as a diagnostic marker and an independent predictor of relapse (high expression indicates poorer relapse-free survival). Functionally, circRNF220 promotes AML cell proliferation/cell-cycle progression and suppresses apoptosis, at least partly by sponging miR-30a to increase expression of targets such as MYSM1 and IER2."	0.889
34703648	Molecular therapy. Nucleic acids	2021	circNUDT21 promotes bladder cancer progression by modulating the miR-16-1-3p/MDM2/p53 axis.		circNUDT21 	hsa_circ_NUDT21	NUDT21	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circNUDT21 is up-regulated in bladder cancer tissues and cell lines and promotes proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, it functions as a ceRNA by sponging miR-16-1-3p to upregulate MDM2 and suppress p53, thereby driving BC progression via the miR-16-1-3p/MDM2/p53 axis."	0.8571
34703649	Molecular therapy. Nucleic acids	2021	m6A modification of circHPS5 and hepatocellular carcinoma progression through HMGA2 expression.	hsa_circ_0021427	circHPS5 	hsa_circ_HPS5	HPS5	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"circHPS5 is up-regulated in HCC tissues/cells and its high level predicts worse survival. It promotes HCC proliferation, migration/invasion, EMT and CSC-like traits, partly via m6A-dependent biogenesis/export (METTL3, YTHDC1) and a ceRNA mechanism sponging miR-370 to upregulate HMGA2."	0.8999
34703650	Molecular therapy. Nucleic acids	2021	Circular RNA circ-TNPO3 suppresses metastasis of GC by acting as a protein decoy for IGF2BP3 to regulate the expression of MYC and SNAIL.	hsa_circ_0001741	circ-TNPO3 	hsa_circ_TNPO3	TNPO3	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; ISH; Microarray	"circ-TNPO3 is down-regulated in gastric cancer tissues and plasma and acts as a tumor suppressor by inhibiting proliferation and migration/metastasis. Mechanistically, it binds IGF2BP3 as a protein decoy, weakening IGF2BP3-mediated stabilization of MYC mRNA and reducing MYC and downstream SNAIL expression. Plasma circ-TNPO3 shows potential diagnostic value, but it is not associated with overall survival in this study."	0.8944
34706132	Cancer science	2022	Hsa_circ_0005576 promotes osimertinib resistance through the miR-512-5p/IGF1R axis in lung adenocarcinoma cells.	hsa_circ_0005576	circ_0005576	hsa_circ_CDC42	CDC42	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0005576 is up-regulated in osimertinib-resistant LUAD cell models and promotes resistance by enhancing proliferation/viability and suppressing apoptosis. It functions as a miRNA sponge for miR-512-5p, thereby upregulating IGF1R and activating downstream AKT and ERK signaling; knockdown sensitizes resistant cells and xenografts to osimertinib."	0.7746
34706645	BMC genomics	2021	circ_0038718 promotes colon cancer cell malignant progression via the miR-195-5p/Axin2 signaling axis and also effect Wnt/beta-catenin signal pathway.	hsa_circ_0038718	circ_0038718 	hsa_circ_IL4R	IL4R	colon cancer 	MONDO:0021063	malignant colon neoplasm	up-regulated	RT-qPCR; Microarray	"circ_0038718 is up-regulated in colon/colorectal cancer and mainly localizes to the cytoplasm. It promotes malignant phenotypes (proliferation, migration, invasion and xenograft tumor growth) by sponging miR-195-5p to upregulate Axin2 and activate Wnt/beta-catenin signaling."	0.8244
34707713	Experimental and therapeutic medicine	2021	Mechanism underlying circularRNA_014301-mediated regulation of neuronal cell inflammation and apoptosis.		circRNA_014301 	rno_circ_MYT1L	MYT1L	spinal cord injury 	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR	"In an LPS-stimulated PC12 cell model relevant to SCI inflammation, circRNA_014301 expression increases and it promotes inflammatory responses and apoptosis. siRNA knockdown of circRNA_014301 reduces inflammatory cytokines and NF-kappaB activation and alleviates apoptosis, suggesting circRNA_014301 as a potential therapeutic/diagnostic target for SCI."	0.5979
34709743	Clinical and translational medicine	2021	A novel tumour suppressor protein encoded by circMAPK14 inhibits progression and metastasis of colorectal cancer by competitively binding to MKK6.	hsa_circ_0131663	circMAPK14 	hsa_circ_MAPK14	MAPK14	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"circMAPK14 (hsa_circ_0131663) is downregulated in colorectal cancer and mainly localized in the cytoplasm. It suppresses CRC proliferation and metastasis by encoding the peptide circMAPK14-175aa, which competes with MAPK14 for MKK6 binding, inhibits MAPK14 nuclear translocation, and promotes FOXC1 ubiquitination/degradation within a FOXC1_U2AF2 positive feedback loop."	0.8192
34709968	Bioengineered	2022	Circular RNA SOX13 promotes malignant behavior and cisplatin resistance in non-small cell lung cancer through targeting microRNA-3194-3p/microtubule-associated protein RP/EB family member 1.		circSOX13 	hsa_circ_SOX13	SOX13	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circSOX13 is up-regulated in NSCLC tissues and patient serum and promotes malignant phenotypes and cisplatin resistance. Mechanistically, circSOX13 sponges miR-3194-3p to up-regulate MAPRE1, enhancing proliferation/migration/invasion and inhibiting apoptosis. circSOX13 knockdown suppresses tumor growth and increases cisplatin sensitivity in a xenograft model."	0.713
34712363	Oncology letters	2021	Circular RNA FOXO3 accelerates glycolysis and improves cisplatin sensitivity in lung cancer cells via the miR-543/Foxo3 axis.		circRNA-FOXO3 	hsa_circ_FOXO3	FOXO3	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"circRNA-FOXO3 is downregulated in NSCLC tissues and in DDP-resistant cells. Its overexpression inhibits glycolysis and increases cisplatin sensitivity by sponging miR-543, thereby relieving miR-543-mediated repression of Foxo3."	0.6956
34712388	Oxidative medicine and cellular longevity	2021	Effect and Mechanism of LRP6 on Cardiac Myocyte Ferroptosis in Myocardial Infarction.	mmu_circ_0001615	circRNA1615 	mmu_circ_Copb1	Copb1	myocardial infarction 	MONDO:0005068	myocardial infarction	down-regulated	RT-qPCR	"In a mouse MI/ferroptosis model, circRNA1615 (mmu_circ_0001615, from Copb1) is down-regulated in infarcted myocardium and hypoxia-treated cardiomyocytes. circRNA1615 inhibits cardiomyocyte ferroptosis by sponging miR-152-3p to derepress LRP6, thereby modulating LRP6-associated autophagy-related ferroptosis."	0.7363
34716285	Aging	2021	CircFAM120B knockdown inhibits osteosarcoma tumorigenesis via the miR-1205/PTBP1 axis.	hsa_circ_0078767	circFAM120B	hsa_circ_FAM120B	FAM120B	Osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circFAM120B (hsa_circ_0078767) is up-regulated in osteosarcoma tissues and cell lines and correlates with advanced TNM stage and metastasis. It promotes osteosarcoma proliferation, colony formation, invasion, and xenograft growth by sponging miR-1205 to increase PTBP1 expression (ceRNA axis)."	0.783
34716310	Cell death & disease	2021	EIF4A3-induced circular RNA PRKAR1B promotes osteosarcoma progression by miR-361-3p-mediated induction of FZD4 expression.		circPRKAR1B 	hsa_circ_PRKAR1B	PRKAR1B	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; ISH	"circPRKAR1B is up-regulated in osteosarcoma and mainly localized in the cytoplasm. It promotes proliferation, migration, EMT, tumor growth and lung metastasis by sponging miR-361-3p to increase FZD4 and activate Wnt/beta-catenin signaling; EIF4A3 facilitates its biogenesis. circPRKAR1B overexpression decreases sensitivity to cisplatin (CDDP), suggesting a role in chemoresistance."	0.848
34716323	Cell death discovery	2021	CircETFA upregulates CCL5 by sponging miR-612 and recruiting EIF4A3 to promote hepatocellular carcinoma.	hsa_circ_0036412	CircETFA	hsa_circ_ETFA	ETFA	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"CircETFA is up-regulated in HCC tissues/plasma/cells and promotes HCC proliferation, invasion and metastasis while inhibiting apoptosis. Mechanistically, it upregulates CCL5 by sponging hsa-miR-612 and by recruiting EIF4A3 to prolong CCL5 mRNA half-life, thereby enhancing PI3K/Akt signaling (including FoxO6). High circETFA is associated with poor overall survival and shows diagnostic potential in plasma."	0.895
34717683	Journal of orthopaedic surgery and research	2021	Doxorubicin inhibits osteosarcoma progression by regulating circ_0000006/miR-646/ BDNF axis.	hsa_circ_0000006				osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	circ_0000006 is up-regulated in osteosarcoma tissues/cells and is reduced by doxorubicin treatment. It promotes malignant phenotypes and DOX resistance by sponging miR-646 to increase BDNF; circ_0000006 knockdown enhances DOX-mediated anti-tumor effects and suppresses xenograft tumor growth.	0.7183
34717684	Journal of orthopaedic surgery and research	2021	Identification of circular RNAs hsa_circ_0140271 in peripheral blood mononuclear cells as a novel diagnostic biomarker for female rheumatoid arthritis.	hsa_circ_0140271		hsa_circ_MED14	MED14	rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; RNA-seq	"This study identifies hsa_circ_0140271 (from MED14) as up-regulated in PBMCs of female rheumatoid arthritis patients and supports its utility as a diagnostic biomarker (including ROC-based discrimination vs HC, OA, and AS). Mechanistically, bioinformatics suggests it may act as a miRNA sponge and relate to fatty acid/lipid metabolism pathways in RA."	0.6841
34721518	Frontiers in genetics	2021	PBX2-Mediated circTLK1 Activates JAK/STAT Signaling to Promote Gliomagenesis via miR-452-5p/SSR1 Axis.		circTLK1	hsa_circ_TLK1	TLK1	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circTLK1 is up-regulated in glioma tissues and cell lines and promotes glioma cell proliferation, migration, invasion, and xenograft growth. Mechanistically, PBX2 enhances circTLK1 expression; circTLK1 functions as a ceRNA sponging miR-452-5p to upregulate SSR1 and activate JAK/STAT signaling."	0.8586
34721542	Frontiers in genetics	2021	Whole-Transcriptome Sequence of Degenerative Meniscus Cells Unveiling Diagnostic Markers and Therapeutic Targets for Osteoarthritis.	hsa_circ_0018069				osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR; RNA-seq	"This study identifies hsa_circ_0018069 as a downregulated circRNA in IL-1beta-stimulated degenerative OA meniscus. It is proposed to regulate a ceRNA axis by sponging miR-147b-3p, thereby affecting TJP2 expression, with a potential protective role against meniscus degeneration."	0.4032
34722233	Frontiers in oncology	2021	CircFAM114A2 Promotes Cisplatin Sensitivity via miR-222-3p/P27 and miR-146a-5p/P21 Cascades in Urothelial Carcinoma.		CircFAM114A2 	hsa_circ_FAM114A2	FAM114A2	urothelial carcinoma	MONDO:0040679	urothelial carcinoma	down-regulated	RT-qPCR; RNA-seq	"circFAM114A2 is downregulated in urothelial carcinoma and functions as a tumor-suppressive circRNA. It sponges miR-222-3p and miR-146a-5p to upregulate P27 and P21, promoting G1 arrest and apoptosis and enhancing cisplatin sensitivity in vitro and in xenograft models; higher expression predicts better survival."	0.8823
34722753	International journal of genomics	2021	circ_0002346 Suppresses Non-Small-Cell Lung Cancer Progression Depending on the Regulation of the miR-582-3p/STXBP6 Axis.	hsa_circ_0002346		hsa_circ_CRIM1	CRIM1	non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"circ_0002346 is down-regulated in NSCLC tissues/cell lines and functions as a tumor suppressor. It mainly localizes to the cytoplasm and inhibits proliferation, migration, invasion, and glycolysis while promoting apoptosis. Mechanistically, it sponges miR-582-3p to upregulate STXBP6 and suppresses xenograft tumor growth."	0.8326
34722778	Journal of immunology research	2021	circ_0001588 Induces the Malignant Progression of Hepatocellular Carcinoma by Modulating miR-874/CDK4 Signaling.	hsa_circ_0001588				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0001588 is up-regulated in HCC and functions as an oncogenic circRNA. It promotes HCC cell proliferation, migration and invasion while inhibiting apoptosis, and enhances xenograft tumor growth by sponging miR-874 to relieve repression of CDK4."	0.6002
34727877	BMC cancer	2021	Knockdown of circSMAD2 inhibits the tumorigenesis of gallbladder cancer through binding with eIF4A3.		circSMAD2	hsa_circ_SMAD2	SMAD2	gallbladder cancer 	MONDO:0005411	gallbladder cancer	up-regulated	RT-qPCR	"circSMAD2 is up-regulated in gallbladder cancer and promotes malignant phenotypes (cell viability, migration and invasion) while suppressing apoptosis. Mechanistically, circSMAD2 binds the RBP eIF4A3, interferes with eIF4A3_SMAD2 binding, and supports SMAD2 expression, linking its effects to TGF-beta/SMAD signaling; circSMAD2 knockdown suppresses xenograft tumor growth."	0.7412
34727925	Cancer cell international	2021	CircRFX3 contributes to glioma progression through the circRFX3-miR-1179/miR-1229-VASP axis.	hsa_circ_0001836	circRFX3 	hsa_circ_RFX3	RFX3	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circRFX3 is up-regulated in glioma and acts as an oncogenic circRNA. It sponges miR-1179 and miR-1229 to increase VASP expression, thereby promoting proliferation, migration/invasion and tumor growth while suppressing apoptosis; high circRFX3 correlates with worse overall survival."	0.8322
34729247	Molecular therapy. Nucleic acids	2021	circ-NOL10 regulated by MTDH/CASC3 inhibits breast cancer progression and metastasis via multiple miRNAs and PDCD4.		circ-NOL10	hsa_circ_NOL10	NOL10	breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	"circ-NOL10 is down-regulated in breast cancer (notably TNBC) and functions as a tumor suppressor by promoting apoptosis and inhibiting proliferation, migration, invasion and xenograft tumor growth. Mechanistically, it is repressed by the RBPs MTDH and CASC3 and sponges miR-149-5p/miR-330-3p/miR-452-5p to upregulate the tumor suppressor PDCD4; low circ-NOL10 is associated with poorer patient outcomes and has diagnostic potential."	0.8072
34730679	Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas	2021	CircRNA has_circ_0001806 promotes hepatocellular carcinoma progression via the miR-193a-5p/MMP16 pathway.	hsa_circ_0001806				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0001806 is overexpressed in HCC tissues and cell lines and promotes HCC cell proliferation, migration, and invasion. Mechanistically, it acts as a ceRNA by sponging miR-193a-5p to relieve repression of MMP16, thereby driving malignant behaviors."	0.8035
34732216	Journal of translational medicine	2021	Circular RNA circ-ERBB2 promotes HER2-positive breast cancer progression and metastasis via sponging miR-136-5p and miR-198.	hsa_circ_0043459	circ-ERBB2	hsa_circ_ERBB2	ERBB2	HER2-positive breast cancer	MONDO:0006244	HER2 positive breast carcinoma	up-regulated	RT-qPCR	"circ-ERBB2 (hsa_circ_0043459) is up-regulated in HER2-positive breast cancer tissues/cells and promotes proliferation, migration, invasion, and metastasis while inhibiting apoptosis. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-136-5p and miR-198 to de-repress TFAP2C, increasing HER2 and activating Akt/ERK signaling; knockdown suppresses tumor growth in a BT-474 xenograft model."	0.7338
34736477	Cancer cell international	2021	CircADARB1 serves as a new biomarker in natural killer T-cell lymphoma and a potential regulator of p-Stat3.	hsa_circ_0005037	circADARB1	hsa_circ_ADARB1	ADARB1	natural killer T-cell lymphoma	MONDO:0005169	neoplasm of mature T-cells or NK-cells	up-regulated	RT-qPCR; Microarray	"circADARB1 is up-regulated in NKTCL patient plasma and may aid diagnosis and predict therapy response. Functionally, circADARB1 promotes NKTCL cell proliferation/tumor growth and suppresses apoptosis, at least partly by sponging miR-214-3p to regulate p-Stat3/STAT3 signaling."	0.7734
34737800	Experimental and therapeutic medicine	2021	"Comprehensive analysis of mRNAs, lncRNAs and circRNAs in the early phase of microglial activation."		CIRCpedia_38964			Sepsis-associated encephalopathy 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR; Microarray	"CIRCpedia_38964 is up-regulated in LPS-stimulated BV-2 microglia (early activation model) and is predicted in a circRNA_miRNA_mRNA ceRNA network to sequester miRNA, potentially increasing Agrn and Lacc1 translation. Its functional significance is described as uncertain and may reflect an inflammation-related biomarker or other roles."	0.2465
34737800	Experimental and therapeutic medicine	2021	"Comprehensive analysis of mRNAs, lncRNAs and circRNAs in the early phase of microglial activation."		CIRCpedia_37520			Sepsis-associated encephalopathy 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR; Microarray	CIRCpedia_37520 is up-regulated in LPS-stimulated BV-2 microglia and was incorporated into a predicted circRNA_miRNA_mRNA network. It is predicted to act via miR-5620-3p to associate with Rapgef2.	0.2465
34737800	Experimental and therapeutic medicine	2021	"Comprehensive analysis of mRNAs, lncRNAs and circRNAs in the early phase of microglial activation."		CIRCpedia_216004			Sepsis-associated encephalopathy 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR; Microarray	"CIRCpedia_216004 is up-regulated in LPS-stimulated BV-2 microglia and was described as the top increased circRNA. It was not included/predicted in the circRNA_miRNA_mRNA ceRNA network, so its mechanism and downstream partners were not established in this study."	0.1904
34737807	Experimental and therapeutic medicine	2021	CircRNA expression profiling of PBMCs from patients with hepatocellular carcinoma by RNA-sequencing.	hsa_circ_0017586		hsa_circ_GDI2	GDI2	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0017586 is up-regulated in PBMCs from HCC patients versus healthy controls (RNA-seq and RT-qPCR). It was evaluated as a potential diagnostic biomarker via ROC analysis, and included in a predicted circRNA_miRNA_mRNA network."	0.4679
34737807	Experimental and therapeutic medicine	2021	CircRNA expression profiling of PBMCs from patients with hepatocellular carcinoma by RNA-sequencing.	hsa_circ_0008304		hsa_circ_TFDP2	TFDP2	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0008304 is down-regulated in PBMCs from HCC patients versus healthy controls (RNA-seq and RT-qPCR). It was assessed as a potential diagnostic biomarker via ROC analysis and included in predicted circRNA_miRNA_mRNA networks.	0.4679
34737807	Experimental and therapeutic medicine	2021	CircRNA expression profiling of PBMCs from patients with hepatocellular carcinoma by RNA-sequencing.	hsa_circ_0001181		hsa_circ_BACH1	BACH1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001181 is up-regulated in PBMCs from HCC patients and shows strong diagnostic performance by ROC analysis. Functionally, its knockdown in HepG2 cells suppresses proliferation, and it is incorporated into predicted ceRNA (circRNA_miRNA_mRNA) networks with specific predicted miRNA binding partners."	0.6368
34737807	Experimental and therapeutic medicine	2021	CircRNA expression profiling of PBMCs from patients with hepatocellular carcinoma by RNA-sequencing.	hsa_circ_0073239		hsa_circ_VCAN	VCAN	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0073239 is up-regulated in PBMCs from HCC patients versus controls, validated by RT-qPCR. It was evaluated as a diagnostic biomarker via ROC analysis and included in predicted circRNA_miRNA_mRNA regulatory networks."	0.5047
34737807	Experimental and therapeutic medicine	2021	CircRNA expression profiling of PBMCs from patients with hepatocellular carcinoma by RNA-sequencing.	hsa_circ_0070190		hsa_circ_BMP2K	BMP2K	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0070190 is up-regulated in PBMCs from HCC patients and validated by RT-qPCR. It was evaluated by ROC analysis as a potential diagnostic biomarker and is part of predicted ceRNA networks, with predicted binding to multiple miRNAs including shared sites (hsa-miR-4659b-3p/hsa-miR-3614-3p/hsa-miR-4659a-3p)."	0.5047
34737807	Experimental and therapeutic medicine	2021	CircRNA expression profiling of PBMCs from patients with hepatocellular carcinoma by RNA-sequencing.	hsa_circ_0000369		hsa_circ_FLI1	FLI1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0000369 is up-regulated in PBMCs from HCC patients and validated by RT-qPCR. It shows high diagnostic potential (high ROC AUC) and is included in predicted circRNA_miRNA_mRNA networks.	0.5047
34737808	Experimental and therapeutic medicine	2021	Identification of potential novel biomarkers for abdominal aortic aneurysm based on comprehensive analysis of circRNA-miRNA-mRNA networks.	hsa_circ_0057691				abdominal aortic aneurysm 	MONDO:0005350	abdominal aortic aneurysm	unknown	Microarray	"hsa_circ_0057691 was identified bioinformatically as part of a central AAA-associated ceRNA module, predicted to interact with miR-330-5p and thereby relate to CNN1-associated functions (e.g., focal adhesion/actin binding). No experimental validation of this circRNA¡¯s expression was reported in patient samples."	0.1768
34737808	Experimental and therapeutic medicine	2021	Identification of potential novel biomarkers for abdominal aortic aneurysm based on comprehensive analysis of circRNA-miRNA-mRNA networks.	hsa_circ_0092108				abdominal aortic aneurysm 	MONDO:0005350	abdominal aortic aneurysm	unknown	Microarray	"hsa_circ_0092108 was identified bioinformatically as part of a central AAA-associated ceRNA module with miR-330-5p and CNN1, implicating it in CNN1-related processes such as focal adhesion/actin binding. No experimental validation of this circRNA¡¯s expression was reported."	0.1768
34737808	Experimental and therapeutic medicine	2021	Identification of potential novel biomarkers for abdominal aortic aneurysm based on comprehensive analysis of circRNA-miRNA-mRNA networks.	hsa_circ_0006845				abdominal aortic aneurysm 	MONDO:0005350	abdominal aortic aneurysm	unknown	Microarray	"hsa_circ_0006845 was bioinformatically implicated in AAA as part of the center axis with miR-330-5p and CNN1, suggesting a ceRNA role connected to focal adhesion/actin binding functions via CNN1. The circRNA itself was not experimentally validated in patient tissues in this study."	0.1768
34737808	Experimental and therapeutic medicine	2021	Identification of potential novel biomarkers for abdominal aortic aneurysm based on comprehensive analysis of circRNA-miRNA-mRNA networks.	hsa_circ_0082182				abdominal aortic aneurysm 	MONDO:0005350	abdominal aortic aneurysm	unknown	Microarray	"hsa_circ_0082182 was predicted as a key circRNA in a central AAA ceRNA module (with miR-330-5p and CNN1), implying a regulatory role in CNN1-related processes such as focal adhesion/actin binding. The study did not experimentally validate this circRNA¡¯s expression changes."	0.1768
34737808	Experimental and therapeutic medicine	2021	Identification of potential novel biomarkers for abdominal aortic aneurysm based on comprehensive analysis of circRNA-miRNA-mRNA networks.	hsa_circ_0061482				abdominal aortic aneurysm 	MONDO:0005350	abdominal aortic aneurysm	unknown	Microarray	"hsa_circ_0061482 was identified by microarray/bioinformatics as a component of a central AAA ceRNA module predicted to bind miR-326 and relate to CD8A upregulation, implicating immune response/T cell activation-related functions. Its expression change was not experimentally validated in this paper."	0.1768
34737808	Experimental and therapeutic medicine	2021	Identification of potential novel biomarkers for abdominal aortic aneurysm based on comprehensive analysis of circRNA-miRNA-mRNA networks.	hsa_circ_0011450				abdominal aortic aneurysm 	MONDO:0005350	abdominal aortic aneurysm	unknown	Microarray	"hsa_circ_0011450 was predicted to participate in a central AAA-associated ceRNA axis with miR-326 and CD8A, linking it to immune response/T cell activation-related functions. No direct experimental validation of this circRNA was provided."	0.1768
34737808	Experimental and therapeutic medicine	2021	Identification of potential novel biomarkers for abdominal aortic aneurysm based on comprehensive analysis of circRNA-miRNA-mRNA networks.	hsa_circ_0008351				abdominal aortic aneurysm 	MONDO:0005350	abdominal aortic aneurysm	unknown	Microarray	"hsa_circ_0008351 was predicted to form a central ceRNA module in AAA with miR-326 and CD8A, suggesting a role in immune-related processes (immune response/T cell activation) through regulating CD8A. This circRNA was not experimentally validated in this work."	0.1768
34737808	Experimental and therapeutic medicine	2021	Identification of potential novel biomarkers for abdominal aortic aneurysm based on comprehensive analysis of circRNA-miRNA-mRNA networks.	hsa_circ_0004121				abdominal aortic aneurysm 	MONDO:0005350	abdominal aortic aneurysm	unknown	Microarray	"hsa_circ_0004121 was bioinformatically identified within a central AAA-related ceRNA axis with miR-326 and CD8A, implicating it in immune response/T cell activation-related functions via CD8A. The study did not validate this circRNA experimentally."	0.1768
34738502	Bioengineered	2021	Knockdown of circular RNA septin 9 inhibits the malignant progression of breast cancer by reducing the expression of solute carrier family 1 member 5 in a microRNA-149-5p-dependent manner.	hsa_circ_0005320		hsa_circ_SEPT9	SEPT9	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circSEPT9 is up-regulated in breast cancer tissues and cell lines and promotes malignant phenotypes (glutamine uptake, proliferation, tumor growth) while inhibiting apoptosis. Mechanistically, circSEPT9 functions as a ceRNA by sponging miR-149-5p, thereby increasing SLC1A5 expression."	0.8006
34738503	Bioengineered	2021	"Circular RNA mitochondrial translation optimization 1 homologue (CircMTO1) induced by zinc finger protein 460 (ZNF460) promotes oral squamous cell carcinoma progression through the microRNA miR-320a / alpha thalassemia/mental retardation, X-linked (ATRX) axis."		CircMTO1 	hsa_circ_MTO1	MTO1	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circMTO1 is upregulated in OSCC tissues and cell lines and promotes OSCC cell proliferation, migration, and invasion. Mechanistically, circMTO1 acts as a ceRNA by sponging miR-320a to increase ATRX expression, and its expression is transcriptionally induced by ZNF460."	0.8519
34740354	Molecular cancer	2021	ciRS-7 is a prognostic biomarker and potential gene therapy target for renal cell carcinoma.	hsa_circ_0001946	ciRS-7	hsa_circ_CDR1	CDR1	renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"ciRS-7 (hsa_circ_0001946), derived from CDR1, is up-regulated in RCC and predominantly cytoplasmic. It promotes RCC proliferation, migration/invasion and in vivo tumor growth/metastasis by sponging miR-139-3p, relieving repression of TAGLN and activating PI3K/AKT signaling; high expression is associated with poor survival."	0.8711
34740363	Reproductive biology and endocrinology : RB&E	2021	Circ_0043532 regulates miR-182/SGK3 axis to promote granulosa cell progression in polycystic ovary syndrome.	hsa_circ_0043532				Polycystic ovary syndrome 	MONDO:0008487	polycystic ovary syndrome	up-regulated	RT-qPCR	"circ_0043532 is up-regulated in PCOS granulosa cells and in KGN cells. Functionally, it promotes proliferation and cell-cycle progression and inhibits apoptosis by sponging miR-182 and thereby relieving repression of SGK3 (circ_0043532/miR-182/SGK3 axis)."	0.7045
34741437	Thoracic cancer	2021	Circular RNA circCPA4 promotes tumorigenesis by regulating miR-214-3p/TGIF2 in lung cancer.	hsa_circ_0082374	circCPA4	hsa_circ_CPA4	CPA4	lung cancer 	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circCPA4 is up-regulated in NSCLC and promotes lung cancer cell proliferation/colony formation, migration, invasion, and cell-cycle progression while inhibiting apoptosis. Mechanistically it functions as a ceRNA that sponges miR-214-3p to increase TGIF2 expression, enhancing tumor growth in a cell line-derived xenograft model; higher circCPA4 predicts worse survival."	0.8593
34742305	Cancer cell international	2021	Circ-RNF121 regulates tumor progression and glucose metabolism by miR-1224-5p/FOXM1 axis in colorectal cancer.		circ-RNF121 	hsa_circ_RNF121	RNF121	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ-RNF121 is up-regulated in colorectal cancer and promotes malignant behaviors (proliferation, migration/invasion, tumor growth) and glycolysis while inhibiting apoptosis. Mechanistically, it functions as a miR-1224-5p sponge to upregulate FOXM1 (circ-RNF121/miR-1224-5p/FOXM1), and it can be secreted in exosomes."	0.7662
34744154	Anti-cancer drugs	2022	Circular RNA circPDSS1 promotes osteosarcoma progression by sponging miR-502-3p and miR-4436a.		circPDSS1 	hsa_circ_PDSS1	PDSS1	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circPDSS1 is up-regulated in osteosarcoma tissues and cell lines and is associated with worse patient survival. Functionally, circPDSS1 promotes proliferation, clonogenic growth, invasion and in vivo tumorigenesis while inhibiting apoptosis. Mechanistically, it mainly localizes to the cytoplasm and sponges miR-502-3p and miR-4436a, influencing survival signaling (Akt/MAPK-related phosphorylation changes)."	0.7592
34744746	Frontiers in pharmacology	2021	CircEpc1 Promotes Ricin Toxin-Induced Inflammation via Activation of NF-kappaB and MAPK Signaling Pathways by Sponging miR-5114.		circEpc1 	mmu_circ_Epc1	Epc1	Ricin Toxin (RT)-induced inflammation 	MONDO:0029000	poisoning	up-regulated	RT-qPCR; RNA-seq	"circEpc1 is up-regulated in RT-treated RAW264.7 macrophages and in RT-injured mouse lungs. It promotes RT-induced inflammatory injury by sponging miR-5114, de-repressing NOD2/RIP2 and activating NF-kappaB and MAPK signaling, increasing TNF-alpha and IL-6 secretion."	0.7684
34747300	Bioengineered	2021	Circular RNA hsa_circ_0002360 promotes non-small cell lung cancer progression through upregulating matrix metalloproteinase 16 and sponging multiple micorRNAs.	hsa_circ_0002360				non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0002360 is up-regulated in NSCLC tissues and cell lines and promotes proliferation, migration, and invasion of NSCLC cells. It functions as a ceRNA that sponges miR-127-5p, miR-145-5p, miR-585-3p, and miR-758-3p to increase MMP16 expression, and high circ_0002360 correlates with shorter overall survival."	0.7444
34749774	Journal of cardiothoracic surgery	2021	CircMMP11 overexpression predicts the poor survival of non-small cell lung cancer and downregulates miR-143 through methylation to suppress cell proliferation.		CircMMP11	hsa_circ_MMP11	MMP-11	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circMMP11 is up-regulated in NSCLC tissues and high circMMP11 level predicts poorer patient survival. Functionally, circMMP11 promotes proliferation of NSCLC cells, at least in part by reducing miR-143 expression via increased miR-143 gene methylation."	0.6524
34750351	Cell death & disease	2021	"Circ_0058106 promotes proliferation, metastasis and EMT process by regulating Wnt2b/beta-catenin/c-Myc pathway through miR-185-3p in hypopharyngeal squamous cell carcinoma."	hsa_circ_0058106		hsa_circ_FN1	FN1	hypopharyngeal squamous cell carcinoma 	MONDO:0044638	hypopharynx squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0058106 is up-regulated in HSCC tumor tissues and promotes proliferation, migration/invasion, tumorigenesis, metastasis and EMT. Mechanistically, it binds (sponges) miR-185-3p and upregulates the Wnt2b/beta-catenin/c-Myc pathway."	0.843
34750955	Journal of cellular and molecular medicine	2021	Knockdown of circular RNA VANGL1 inhibits TGF-beta-induced epithelial-mesenchymal transition in melanoma cells by sponging miR-150-5p.		circVANGL1 	hsa_circ_VANGL1	VANGL1	melanoma	MONDO:0005105	melanoma	up-regulated	RT-qPCR	"circVANGL1 is up-regulated in melanoma tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion) and TGF-beta-induced EMT. Mechanistically, circVANGL1 predominantly localizes to the cytoplasm and directly binds/sponges miR-150-5p; restoring miR-150-5p counteracts circVANGL1-driven effects."	0.7081
34753388	Bioengineered	2021	Circ-Usp10 promotes microglial activation and induces neuronal death by targeting miRNA-152-5p/CD84.	mmu_circ_0014637		mmu_circ_Usp10	Usp10	Spinal cord injury 	MONDO:0043797	spinal cord injury	down-regulated	RT-qPCR; RNA-seq	"In a mouse SCI model and BV2 microglia, circ-Usp10 (mmu_circ_0014637) is decreased but functionally promotes microglial/macrophage activation by acting as a ceRNA for miR-152-5p to regulate CD84. Silencing circ-Usp10 reduces proinflammatory cytokines (IL-6, TNF-alpha) and decreases neuronal death in HT22 cells exposed to microglial supernatant."	0.5804
34753398	Bioengineered	2021	Circular RNA_0037128 aggravates high glucose-induced damage in HK-2 cells via regulation of microRNA-497-5p/nuclear factor of activated T cells 5 axis.	hsa_circ_0037128		hsa_circ_NPRL3	NPRL3	diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"circ_0037128 is up-regulated in DN patient kidney tissues and in high-glucose_treated HK-2 cells. Functionally, it aggravates HG-induced injury by promoting oxidative stress, inflammation, and fibrotic marker expression while suppressing proliferation. Mechanistically, it sponges miR-497-5p to increase NFAT5 expression (circ_0037128/miR-497-5p/NFAT5 axis)."	0.7782
34753486	Molecular cancer	2021	Cancer cell-derived exosomal circUSP7 induces CD8+ T cell dysfunction and anti-PD1 resistance by regulating the miR-934/SHP2 axis in NSCLC.	hsa_circ_0005152	circUSP7 	hsa_circ_USP7	USP7	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circUSP7 (hsa_circ_0005152), derived from USP7, is up-regulated in NSCLC tissues and enriched in plasma/cancer cell-derived exosomes. It is transferred to CD8+ T cells where it sponges miR-934, increases SHP2, induces CD8+ T cell dysfunction/exhaustion, and is associated with poor prognosis and anti-PD1 resistance."	0.8103
34754206	"Diabetes, metabolic syndrome and obesity : targets and therapy"	2021	CircRNA circVEGFC is Highly Expressed in Gestational Diabetes Mellitus (GDM) and It is Correlated with Multiple Adverse Events.		circVEGFC		VEGFC	gestational diabetes mellitus 	MONDO:0005406	gestational diabetes	up-regulated	RT-qPCR	circVEGFC is up-regulated in the plasma of GDM patients and is higher even early in pregnancy among those who later develop GDM. Plasma circVEGFC shows good early diagnostic performance (ROC AUC ~0.89) and higher levels are associated with increased risk of fetal malformation and maternal hypertension.	0.4758
34754888	Regenerative therapy	2021	RUNX3 derived hsa_circ_0005752 accelerates the osteogenic differentiation of adipose-derived stem cells via the miR-496/MDM2-p53 pathway.	hsa_circ_0005752		hsa_circ_LPAR1	LPAR1	osteoporosis	MONDO:0005298	osteoporosis	up-regulated	RT-qPCR	"In OM-induced ADSC osteogenesis (osteoporosis-relevant context), hsa_circ_0005752 is up-regulated and promotes osteogenic differentiation. It functions as a ceRNA that sponges miR-496 to increase MDM2 and suppress p53, and its expression is transcriptionally enhanced by RUNX3 via the LPAR1 promoter."	0.6145
34756880	The Journal of investigative dermatology	2022	Human Papillomavirus_Positive and _Negative Vulvar Squamous Cell Carcinoma Are Biologically but Not Clinically Distinct.		HPV16 circular E7 RNA 		E7	vulvar squamous cell carcinoma 	MONDO:0024609	vulvar squamous cell carcinoma	unknown	RT-qPCR; RNA-seq	"The study detected HPV16-derived circE7 in a subset of VSCC tumors and found it was more frequently present in HPV-positive cases. However, circE7 presence did not associate with overall or progression-free survival, so it was not supported as a VSCC biomarker in this cohort."	0.5958
34758510	"Hepatology (Baltimore, Md.)"	2022	IL-6-induced cGGNBP2 encodes a protein to promote cell growth and metastasis in intrahepatic cholangiocarcinoma.	hsa_circ_0003930	circRNA GGNBP2 	hsa_circ_GGNBP2	ggnbp2	intrahepatic cholangiocarcinoma 	MONDO:0003210	intrahepatic cholangiocarcinoma	up-regulated	RT-qPCR; RNA-seq	"In ICC, IL-6 induces up-regulation of cGGNBP2, whose biogenesis is inhibited by DHX9. cGGNBP2 promotes tumor growth and metastasis mainly by encoding cGGNBP2-184aa, which activates JAK/STAT signaling via STAT3 Tyr705 phosphorylation, and high cGGNBP2 is associated with poor prognosis."	0.8913
34759275	Cell death & disease	2021	Circ-SIRT1 inhibits cardiac hypertrophy via activating SIRT1 to promote autophagy.	hsa_circ_0093884		hsa_circ_SIRT1	SIRT1	cardiac hypertrophy 	MONDO:0001302	hypertensive heart disease	down-regulated	RT-qPCR	"In cardiac hypertrophy models, circ-SIRT1 is down-regulated and acts as an anti-hypertrophic factor. It promotes autophagy and suppresses hypertrophy by increasing SIRT1 via miR-3681-3p/miR-5195-3p sponging and by recruiting USP22 to deubiquitinate and stabilize SIRT1 protein."	0.7726
34759275	Cell death & disease	2021	Circ-SIRT1 inhibits cardiac hypertrophy via activating SIRT1 to promote autophagy.	mmu_circ_0002354		mmu_circ_Sirt1	Sirt1	cardiac hypertrophy 	MONDO:0001302	hypertensive heart disease	down-regulated	RT-qPCR	"In cardiac hypertrophy models (H9c2 cells and mouse hearts), circ-Sirt1 is down-regulated and exerts protective effects against hypertrophy. Overexpression of circ-Sirt1 attenuates CH markers and is associated with increased Sirt1 in vivo."	0.6435
34759742	Saudi journal of biological sciences	2021	Integrative and in-vitro analysis reveal hsa_circ_001787 can act as a diagnostic biomarker for colorectal cancer.	hsa_circ_0000034	hsa_circ_001787 	hsa_circ_DHDDS	DHDDS	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"hsa_circ_001787 is significantly down-regulated in colorectal cancer tissues and shows diagnostic value (AUC ~0.83). The study proposes that it functions as a ceRNA/miRNA sponge within a circRNA_miRNA_mRNA network involving miR-1204, miR-450b-3p, miR-769-3p and miR-1270 and downstream genes including FGF13, KCNB1, RNF217 and SARGAP2."	0.559
34759745	Saudi journal of biological sciences	2021	CircRNA PLOD2 enhances ovarian cancer propagation by controlling miR-378.		circRNA PLOD2 	hsa_circ_PLOD2	PLOD2	ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circ-LOPD2 (circRNA derived from PLOD2) is up-regulated in ovarian cancer tissues/cells and promotes ovarian cancer cell proliferation. Mechanistically, it directly binds miR-378 as a sponge and inversely regulates miR-378 expression."	0.6369
34760337	Molecular therapy. Nucleic acids	2021	HnRNP-L-regulated circCSPP1/miR-520h/EGR1 axis modulates autophagy and promotes progression in prostate cancer.		circCSPP1	hsa_circ_CSPP1	CSPP1	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; RNA-seq; Microarray	"circCSPP1 is up-regulated in prostate cancer tissues/cells and mainly localizes to the cytoplasm. It is promoted by the RBP HnRNP-L and functions as a ceRNA to sponge miR-520h, thereby increasing EGR1 and inducing autophagy, which enhances proliferation, migration, invasion and xenograft tumor growth; higher circCSPP1 tends to associate with faster biochemical recurrence."	0.853
34763084	Molecular therapy : the journal of the American Society of Gene Therapy	2022	Circular RNA circ-FoxO3 attenuates blood-brain barrier damage by inducing autophagy during ischemia/reperfusion.	hsa_circ_0006404	circ-FoxO3	hsa_circ_FoxO3	FoxO3	ischemia	MONDO:0005053	ischemic disease	up-regulated	RT-qPCR; ISH	"circ-FoxO3 is up-regulated in BMECs during cerebral ischemia/reperfusion and hemorrhagic transformation and protects BBB integrity by reducing endothelial barrier permeability. It activates autophagy primarily by sequestering mTOR and E2F1, inhibiting mTORC1 signaling, which helps clear cytotoxic aggregates and attenuate BBB collapse."	0.7822
34763084	Molecular therapy : the journal of the American Society of Gene Therapy	2022	Circular RNA circ-FoxO3 attenuates blood-brain barrier damage by inducing autophagy during ischemia/reperfusion.	mmu_circ_0002207	circ-FoxO3	mmu_circ_FoxO3	FoxO3	ischemia	MONDO:0005053	ischemic disease	up-regulated	RT-qPCR; ISH	"circ-FoxO3 is up-regulated in BMECs during cerebral ischemia/reperfusion and hemorrhagic transformation and protects BBB integrity by reducing endothelial barrier permeability. It activates autophagy primarily by sequestering mTOR and E2F1, inhibiting mTORC1 signaling, which helps clear cytotoxic aggregates and attenuate BBB collapse."	0.7822
34764360	Scientific reports	2021	The human TRAM1 locus expresses circular RNAs.	hsa_circ_0084756	circTRAM1-56 	hsa_circ_TRAM1	TRAM1	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"circTRAM1-56 is a TRAM1-derived human circular RNA validated as an authentic circRNA (BSJ sequencing, RNase H/asON evidence, RNase R resistance). It is down-regulated in urine from high-risk bladder cancer patients and shows only minor reduction with low expression in bladder cancer cell lines, suggesting limited robustness as a urine biomarker on its own."	0.5909
34764360	Scientific reports	2021	The human TRAM1 locus expresses circular RNAs.	hsa_circ_0084757	circTRAM1-57 	hsa_circ_TRAM1	TRAM1	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"circTRAM1-57 is a TRAM1-derived human circular RNA validated as authentic by circRNA-specific PCR and sequencing, tandem repeat exclusion, and RNase R resistance. It is down-regulated in urine from high-risk bladder cancer patients, but shows only minor reduction and low abundance in bladder cancer cell lines, limiting robustness for urine detection without additional markers."	0.5909
34764783	Central-European journal of immunology	2021	Knockdown of circular RNA hsa_circ_0003204 inhibits oxidative stress and apoptosis through the miR-330-5p/Nod2 axis to ameliorate endothelial cell injury induced by low-density lipoprotein.	hsa_circ_0003204		hsa_circ_USP36	USP36	Atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"In an ox-LDL-induced endothelial injury (atherosclerosis cell model), hsa_circ_0003204 is up-regulated and promotes oxidative stress and apoptosis. Silencing hsa_circ_0003204 alleviates injury by sponging miR-330-5p and reducing Nod2 expression (hsa_circ_0003204/miR-330-5p/Nod2 axis)."	0.5554
34764803	Central-European journal of immunology	2021	Hsa_circ_0010957 knockdown attenuates lipopolysaccharide-induced HK2 cell injury by regulating the miR-1224-5p/IRAK1 axis.	hsa_circ_0010957		hsa_circ_SELENON		lupus nephritis	MONDO:0005556	lupus nephritis	up-regulated	RT-qPCR	"In an LPS-induced HK2 cell model of lupus nephritis-like injury, hsa_circ_0010957 is up-regulated and aggravates apoptosis, inflammatory cytokine release, and oxidative injury. Silencing hsa_circ_0010957 protects HK2 cells by sponging miR-1224-5p to reduce IRAK1 expression (hsa_circ_0010957/miR-1224-5p/IRAK1 axis)."	0.6253
34764979	Frontiers in genetics	2021	Expression Profile and Potential Function of Circular RNAs in Peripheral Blood Mononuclear Cells in Male Patients With Primary Gout.	hsa_circ_0069977	hsa_circRNA_103657			primary gout 	MONDO:0005393	gout	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_103657 is up-regulated in PBMCs of male patients with primary gout and shows diagnostic potential (AUC 0.801). Bioinformatic prediction suggests it may act via a circRNA_miRNA_mRNA (ceRNA) network, with downstream enrichment in PI3K-Akt signaling and associations with lipid/glucose metabolism parameters."	0.5963
34764979	Frontiers in genetics	2021	Expression Profile and Potential Function of Circular RNAs in Peripheral Blood Mononuclear Cells in Male Patients With Primary Gout.	hsa_circ_0000241	hsa_circRNA_000241			primary gout 	MONDO:0005393	gout	up-regulated	RT-qPCR; Microarray	hsa_circRNA_000241 (hsa_circ_0000241) is up-regulated in PBMCs of male patients with primary gout and shows diagnostic value (AUC 0.726). It is predicted to function through a circRNA_miRNA_mRNA (ceRNA) network and is positively correlated with triglycerides in gout patients.	0.5963
34764979	Frontiers in genetics	2021	Expression Profile and Potential Function of Circular RNAs in Peripheral Blood Mononuclear Cells in Male Patients With Primary Gout.	hsa_circ_0088494	hsa_circRNA_104917			primary gout 	MONDO:0005393	gout	down-regulated	RT-qPCR; Microarray	hsa_circRNA_104917 (hsa_circ_0088494) was identified as down-regulated in PBMCs of primary gout patients versus healthy controls in microarray data and showed a consistent trend in the initial qRT-PCR verification set. The study did not report further mechanistic or clinical analyses for this circRNA.	0.4773
34764979	Frontiers in genetics	2021	Expression Profile and Potential Function of Circular RNAs in Peripheral Blood Mononuclear Cells in Male Patients With Primary Gout.	hsa_circ_0001343	hsa_circRNA_001594			primary gout 	MONDO:0005393	gout	down-regulated	RT-qPCR; Microarray	hsa_circRNA_001594 (hsa_circ_0001343) was identified as down-regulated in PBMCs of primary gout patients versus healthy controls in microarray data and showed a consistent trend in the initial qRT-PCR verification set. The study did not report further mechanistic or clinical analyses for this circRNA.	0.4773
34765599	Frontiers in cell and developmental biology	2021	Circ_0000215 Exerts Oncogenic Function in Nasopharyngeal Carcinoma by Targeting miR-512-5p.	hsa_circ_0000215	Circ_0000215	hsa_circ_CAMK1D	CAMK1D	Nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"circ_0000215 is up-regulated in nasopharyngeal carcinoma and promotes malignant phenotypes (proliferation, migration/invasion, EMT, tumor growth and lung metastasis). Mechanistically, it sponges miR-512-5p to increase PIK3R1 expression and is linked to ERBB signaling activation (including ERBB2 upregulation)."	0.8279
34768001	Molecular therapy : the journal of the American Society of Gene Therapy	2022	Microglia secrete miR-146a-5p-containing exosomes to regulate neurogenesis in depression.		circular RNA ANKS1B 	rno_circ_ANKS1B	ANKS1B	depression 	MONDO:0002050	depressive disorder	down-regulated	RT-qPCR; RNA-seq	"In a CUMS rat depression model, circANKS1B is decreased in hippocampal DG. circANKS1B acts as a miR-146a-5p sponge to modulate KLF4 (and downstream CDKL5/STAT3 signaling), thereby promoting DG neurogenesis and improving depression-like behaviors when overexpressed."	0.5008
34771489	Cancers	2021	"A DOCK1 Gene-Derived Circular RNA Is Highly Expressed in Luminal Mammary Tumours and Is Involved in the Epithelial Differentiation, Growth, and Motility of Breast Cancer Cells."	hsa_circ_0020397	circDOCK1-1	hsa_circ_DOCK1	DOCK1	breast cancer 	MONDO:0007254	breast cancer	dysregulated	RT-qPCR	"circDOCK1-1 (hsa_circ_0020397), derived from DOCK1, is high in luminal/epithelial breast cancer cell lines but low/undetectable in triple-negative mesenchymal lines. Overexpression promotes epithelial differentiation and cell_cell adhesion while inhibiting proliferation and motility, accompanied by transcriptomic changes in a common set of genes; a miRNA-sponge ceRNA mechanism is proposed in silico (e.g., involving hsa-mir-539-3p and hsa-miR-545-3p) but not functionally confirmed."	0.5008
34774079	Journal of ovarian research	2021	RNA-binding protein IGF2BP2 enhances circ_0000745 abundancy and promotes aggressiveness and stemness of ovarian cancer cells via the microRNA-3187-3p/ERBB4/PI3K/AKT axis.	hsa_circ_0000745	circ_0000745 	hsa_circ_SPECC1	SPECC1	ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circ_0000745 is upregulated in ovarian cancer tissues and cell lines and promotes malignant phenotypes including proliferation, migration/invasion, EMT, and stemness. Mechanistically, it sponges miR-3187-3p to increase ERBB4 and activate PI3K/AKT signaling, and IGF2BP2 binds circ_0000745 to enhance its abundance/stability."	0.8174
34774083	Journal of translational medicine	2021	Circular RNA circPIP5K1A contributes to cancer stemness of osteosarcoma by miR-515-5p/YAP axis.		circPIP5K1A 	hsa_circ_PIP5K1A	PIP5K1A	osteosarcoma	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circPIP5K1A is up-regulated in osteosarcoma tissues and promotes malignant phenotypes including proliferation, invasion/migration, EMT-like changes, and cancer stemness. Mechanistically, it functions through a ceRNA axis by sponging miR-515-5p to increase YAP/YAP1, and its knockdown suppresses tumor growth in a nude mouse xenograft model."	0.6287
34775467	Cell death & disease	2021	CircESRP1 inhibits clear cell renal cell carcinoma progression through the CTCF-mediated positive feedback loop.		circESRP1	hsa_circ_ESRP1	ESRP1	renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	down-regulated	RT-qPCR; Microarray	"circESRP1 is down-regulated in ccRCC and functions as a tumor suppressor. It sponges miR-3942/miR-3942-5p to relieve repression of CTCF, while CTCF transcriptionally promotes circESRP1 to form a positive feedback loop that inhibits c-Myc-mediated EMT and ccRCC progression."	0.8972
34776969	Frontiers in pharmacology	2021	Angiogenesis is Inhibited by Arsenic Trioxide Through Downregulation of the CircHIPK3/miR-149-5p/FOXO1/VEGF Functional Module in Rheumatoid Arthritis.	hsa_circ_0000284	CircHIPK3 	hsa_circ_HIPK3	HIPK3	rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in TNF-alpha_induced RA-FLS and promotes synovial angiogenesis by acting as a miR-149-5p sponge to increase FOXO1 and downstream VEGF. Arsenic trioxide suppresses this circHIPK3/miR-149-5p/FOXO1/VEGF module, and circHIPK3 knockdown alleviates angiogenesis and arthritis severity in CIA mice."	0.8442
34777465	Frontiers in genetics	2021	RNA Biological Characteristics at the Peak of Cell Death in Different Hereditary Retinal Degeneration Mutants.	mmu_circ_0000135				retinitis pigmentosa 	MONDO:0019200	retinitis pigmentosa	down-regulated	RT-qPCR; RNA-seq	"mmu-cicr0000135 (circ0000135) is down-regulated in retinal tissue at the peak of photoreceptor cell death in Pde6b rd1 and Pde6b rd10 mouse retinal degeneration models, validated by RT-qPCR."	0.4625
34777635	Disease markers	2021	Construction of the circRNA-miRNA-mRNA Regulatory Network of an Abdominal Aortic Aneurysm to Explore Its Potential Pathogenesis.	hsa_circ_0011449				Abdominal aortic aneurysm 	MONDO:0005350	abdominal aortic aneurysm	down-regulated	Microarray	"hsa_circ_0011449 was identified (by microarray + computational prediction) as a differentially expressed circRNA in AAA and included in a predicted ceRNA network. It may regulate hub genes (SOD2, CCR7, and PGRMC1) by sponging hsa-let-7f-5p (and hsa-let-7e-5p for PGRMC1), but this axis was not experimentally validated."	0.1768
34777635	Disease markers	2021	Construction of the circRNA-miRNA-mRNA Regulatory Network of an Abdominal Aortic Aneurysm to Explore Its Potential Pathogenesis.	hsa_circ_0081968				Abdominal aortic aneurysm 	MONDO:0005350	abdominal aortic aneurysm	down-regulated	Microarray	hsa_circ_0081968 was identified (by microarray + computational prediction) as downregulated in AAA and incorporated into a predicted ceRNA network. It may sponge hsa-let-7f-5p/hsa-let-7e-5p to influence hub genes (SOD2/CCR7/PGRMC1) and may also participate in a hsa-miR-107_FGFRL1/PLEKHF2 axis; these interactions were not experimentally validated.	0.1768
34777635	Disease markers	2021	Construction of the circRNA-miRNA-mRNA Regulatory Network of an Abdominal Aortic Aneurysm to Explore Its Potential Pathogenesis.	hsa_circ_0005073	hsa_circ_005073			Abdominal aortic aneurysm 	MONDO:0005350	abdominal aortic aneurysm	down-regulated	Microarray	"hsa_circ_0005073 was identified as downregulated in AAA (microarray) and proposed, via bioinformatic ceRNA modeling, to participate in an hsa-miR-107 axis regulating FGFRL1/PLEKHF2, potentially contributing to aneurysm formation. No experimental validation of this mechanism was performed."	0.1768
34779488	International journal of molecular medicine	2022	circPhc3 sponging microRNA_93_3p is involved in the regulation of chondrocyte function by mechanical instability in osteoarthritis.	mmu_circ_0010621	circPhc3	mmu_circ_Phc3	Phc3	osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR; ISH	"circPhc3 is down-regulated in human and mouse OA cartilage and in mechanically stressed chondrocytes. Functionally, circPhc3 supports ECM synthesis (Aggrecan, Col2alpha1) and suppresses MMP-3 production, mainly via a ceRNA mechanism involving miR-93-3p and its target FoxO1."	0.6815
34781747	mBio	2021	"A Previously Undiscovered Circular RNA, circTNFAIP3, and Its Role in Coronavirus Replication."	ssc_circ_0025549	circTNFAIP3	ssc_circ_TNFAIP3	TNFAIP3	porcine deltacoronavirus infection 	MONDO:0024990	swine disease	up-regulated	RT-qPCR; RNA-seq	"circTNFAIP3 (ssc_circ_0025549), a porcine circRNA derived from TNFAIP3, is up-regulated during PDCoV infection and promotes viral replication. Mechanistically, it inhibits PDCoV-induced apoptosis (reduced caspase-3 cleavage) and its pro-viral effect is independent of miRNA sponging despite AGO2 association."	0.7859
34781814	Bioengineered	2021	Regulation of transforming growth factor-beta1 by circANKS1B/miR-515-5p affects the metastatic potential and cisplatin resistance in oral squamous cell carcinoma.	hsa_circ_0007294	circANKS1B	hsa_circ_ANKS1B	ANKS1B	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circANKS1B is up-regulated in OSCC tissues/cells and promotes metastatic phenotypes (invasion, migration, EMT). It increases cisplatin resistance by supporting viability and suppressing apoptosis, acting as a ceRNA that sponges miR-515-5p to relieve repression of TGF-beta1."	0.705
34781898	"Molecular medicine (Cambridge, Mass.)"	2021	Global identification of circular RNAs in imatinib (IM) resistance of chronic myeloid leukemia (CML) by modulating signaling pathways of circ_0080145/miR-203/ABL1 and circ 0051886/miR-637/ABL1.	hsa_circ_0080145				chronic myeloid leukemia 	MONDO:0011996	"chronic myelogenous leukemia, BCR-ABL1 positive"	up-regulated	RT-qPCR	"circ_0080145 is up-regulated in imatinib non-responder CML patients and in IM-resistant K562/R cells. It sponges miR-203, leading to increased ABL1 expression and promoting proliferation, inhibiting apoptosis, and contributing to imatinib chemoresistance."	0.6479
34781898	"Molecular medicine (Cambridge, Mass.)"	2021	Global identification of circular RNAs in imatinib (IM) resistance of chronic myeloid leukemia (CML) by modulating signaling pathways of circ_0080145/miR-203/ABL1 and circ 0051886/miR-637/ABL1.	hsa_circ_0051886				chronic myeloid leukemia 	MONDO:0011996	"chronic myelogenous leukemia, BCR-ABL1 positive"	up-regulated	RT-qPCR	"circ_0051886 is up-regulated in imatinib non-responder CML patients and in IM-resistant K562/R cells. It sponges miR-637, increasing ABL1 expression and promoting proliferation, inhibiting apoptosis, and contributing to imatinib chemoresistance."	0.6479
34781898	"Molecular medicine (Cambridge, Mass.)"	2021	Global identification of circular RNAs in imatinib (IM) resistance of chronic myeloid leukemia (CML) by modulating signaling pathways of circ_0080145/miR-203/ABL1 and circ 0051886/miR-637/ABL1.	hsa_circ_0134501				chronic myeloid leukemia 	MONDO:0011996	"chronic myelogenous leukemia, BCR-ABL1 positive"	dysregulated	RT-qPCR	"circ 0134501 shows altered expression between imatinib responder vs non-responder CML patients and between K562 vs IM-resistant K562/R cells, but its direction is inconsistent across these two contexts and no mechanism was established in this study."	0.2995
34781898	"Molecular medicine (Cambridge, Mass.)"	2021	Global identification of circular RNAs in imatinib (IM) resistance of chronic myeloid leukemia (CML) by modulating signaling pathways of circ_0080145/miR-203/ABL1 and circ 0051886/miR-637/ABL1.	hsa_circ_0134491				chronic myeloid leukemia 	MONDO:0011996	"chronic myelogenous leukemia, BCR-ABL1 positive"	dysregulated	RT-qPCR	"circ 0134491 is differentially expressed between imatinib responder vs non-responder CML patients and between K562 vs IM-resistant K562/R cells, but with opposite directions in these two settings; no downstream mechanism was validated in this study."	0.2995
34781990	Journal of hematology & oncology	2021	Circular RNA circHERC4 as a novel oncogenic driver to promote tumor metastasis via the miR-556-5p/CTBP2/E-cadherin axis in colorectal cancer.	hsa_circ_0007113	circHERC4 	hsa_circ_HERC4	HERC4	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"circHERC4 (hsa_circ_0007113), derived from the HERC4 gene, is up-regulated in colorectal cancer and promotes proliferation and metastasis. It functions mainly in the cytoplasm by binding/inhibiting miR-556-5p, thereby increasing CTBP2 and suppressing E-cadherin, which facilitates metastatic progression; high circHERC4 indicates poor prognosis."	0.8831
34781999	Journal of experimental & clinical cancer research : CR	2021	CircRNA-DOPEY2 enhances the chemosensitivity of esophageal cancer cells by inhibiting CPEB4-mediated Mcl-1 translation.	hsa_circ_0008078	cDOPYE2 	hsa_circ_DOPEY2	DOPEY2	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	"cDOPEY2 (hsa_circ_0008078) is down-regulated in cisplatin-resistant ESCC and acts as a cytoplasmic protein scaffold. It promotes TRIM25-dependent ubiquitination and degradation of CPEB4, reducing CPEB4-driven Mcl-1 translation, thereby increasing cisplatin-induced apoptosis and improving chemosensitivity; low cDOPEY2 is associated with poor clinical outcomes and weaker cisplatin response."	0.8932
34783205	Journal of gynecologic oncology	2022	Circular RNA intraflagellar transport 80 facilitates endometrial cancer progression through modulating miR-545-3p/FAM98A signaling.	hsa_circ_0067835	circ-IFT80 	hsa_circ_IFT80	IFT80	Endometrial cancer 	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR	"circ-IFT80 is up-regulated in endometrial cancer and promotes malignant phenotypes (proliferation, migration, invasion, angiogenesis) while inhibiting apoptosis. Mechanistically, it acts as a cytoplasmic miRNA sponge for miR-545-3p, relieving repression of FAM98A and thereby enhancing tumor progression, including xenograft growth."	0.8175
34784267	Bosnian journal of basic medical sciences	2022	"CircFOXM1 promotes the proliferation, migration, invasion, and glutaminolysis of glioblastoma by regulating the miR-577/E2F5 axis."	hsa_circ_0025033	circFOXM1	hsa_circ_FOXM1	FOXM1	glioblastoma 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR	"circFOXM1 is up-regulated in glioblastoma tissues and cell lines. Functionally, circFOXM1 promotes GBM proliferation, migration, invasion, glutaminolysis and xenograft tumor growth by sponging miR-577, thereby relieving repression of the downstream target E2F5."	0.8436
34784951	Journal of ovarian research	2021	Knockdown of circ-FURIN suppresses the proliferation and induces apoptosis of granular cells in polycystic ovary syndrome via miR-195-5p/BCL2 axis.	hsa_circ_0036881	circ-FURIN	hsa_circ_FURIN	FURIN	polycystic ovary syndrome 	MONDO:0008487	polycystic ovary syndrome	up-regulated	RT-qPCR	"circ-FURIN is upregulated in PCOS cumulus/granulosa-related cells and promotes granulosa cell proliferation while inhibiting apoptosis. Mechanistically, circ-FURIN sponges miR-195-5p to increase BCL2 expression, with effects linked to reduced p-PI3K after circ-FURIN knockdown."	0.7936
34784955	Journal of ovarian research	2021	Curcumin inhibits ovarian cancer progression by regulating circ-PLEKHM3/miR-320a/SMG1 axis.	hsa_circ_0036882	Circ_0001095 	hsa_circ_PLEKHM3	PLEKHM3	ovarian cancer	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR	"circ-PLEKHM3 is down-regulated in ovarian cancer and is upregulated by curcumin treatment. Functionally, circ-PLEKHM3 suppresses ovarian cancer cell proliferation/colony formation and promotes apoptosis, enhancing curcumin¡¯s anti-tumor effects in vitro and in a xenograft model. Mechanistically, circ-PLEKHM3 sponges miR-320a to derepress SMG1, forming a circ-PLEKHM3/miR-320a/SMG1 ceRNA axis."	0.6811
34785951	Cancer management and research	2021	A Novel Circular RNA circPTCD3 Promotes Breast Cancer Progression Through Sponging miR-198.	hsa_circ_0055478	circPTCD3 	hsa_circ_PTCD3	PTCD3	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circPTCD3 (hsa_circ_0055478), derived from PTCD3 exons 3_9, is up-regulated in breast cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes breast cancer cell proliferation and migration and enhances xenograft tumor growth by acting as a ceRNA that sponges miR-198."	0.8275
34785952	Cancer management and research	2021	Knockdown of hsa_circ_0000729 Inhibits the Tumorigenesis of Non-Small Cell Lung Cancer Through Mediation of miR-1281/FOXO3 Axis.	hsa_circ_0000729				non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0000729 is up-regulated in NSCLC cell lines and acts as an oncogenic circRNA. Its knockdown suppresses proliferation, migration and invasion and induces pyroptosis, partly via the miR-1281/FOXO3 axis, and also inhibits tumor growth in a xenograft model."	0.6001
34786378	Journal of hepatocellular carcinoma	2021	CircANTXR1 Contributes to the Malignant Progression of Hepatocellular Carcinoma by Promoting Proliferation and Metastasis.	hsa_circ_0055033	circANTXR1 	hsa_circ_ANTXR1	ANTXR1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circANTXR1 is up-regulated in HCC tissues/cells and promotes proliferation and metastasis. Mechanistically, it sponges miR-532-5p to increase XRCC5 expression, and it is transported via exosomes; serum exosomal circANTXR1 shows diagnostic potential and high tumor expression predicts worse survival."	0.8283
34787049	Bioengineered	2021	"Circular RNA UBR1 promotes the proliferation, migration, and invasion but represses apoptosis of lung cancer cells via modulating microRNA-545-5p/SSFA2 axis."		circ-UBR1 	hsa_circ_UBR1	UBR1	Lung cancer 	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circ-UBR1 is up-regulated in lung cancer tissues/cells and acts as an oncogenic circRNA by binding and repressing miR-545-5p, thereby relieving miR-545-5p-mediated inhibition of SSFA2. Functionally, circ-UBR1 promotes proliferation, migration and invasion and inhibits apoptosis of lung cancer cells, and its knockdown suppresses tumor growth in a xenograft model."	0.7132
34787053	Bioengineered	2021	Circular RNA cerebellar degeneration-related protein 1 antisense RNA (Circ-CDR1as) downregulation induced by dexmedetomidine treatment protects hippocampal neurons against hypoxia/reoxygenation injury through the microRNA-28-3p (miR-28-3p)/tumor necrosis factor receptor-associated factor-3 (TRAF3) axis.		circ-CDR1as 	mmu_circ_CDR1AS		cerebral ischemia	MONDO:0002679	cerebral infarction	up-regulated	RT-qPCR	"In a CI/R in-vitro model (H/R-treated HT-22 hippocampal neurons), circ-CDR1as is induced by H/R but reduced by dexmedetomidine (DEX). Functionally, circ-CDR1as promotes neuronal injury phenotypes (reduced viability, increased apoptosis and inflammatory cytokines) by sponging miR-28-3p to upregulate TRAF3, thereby counteracting DEX-mediated neuroprotection."	0.5554
34787058	Bioengineered	2022	CircSLC7A6 promotes the progression of Wilms' tumor via microRNA-107/ ABL proto-oncogene 2 axis.		circSLC7A6	hsa_circ_SLC7A6	SLC7A6	Wilms¡¯ tumor 	MONDO:0006058	Wilms tumor	up-regulated	RT-qPCR	"circSLC7A6 is up-regulated in Wilms¡¯ tumor tissues and cell lines and promotes malignant phenotypes (proliferation/viability, migration, invasion) while suppressing apoptosis. Mechanistically, it functions as a ceRNA that sponges miR-107 to upregulate ABL2, and its knockdown inhibits xenograft tumor growth."	0.7365
34787066	Bioengineered	2022	Circular RNA circ_0048764 promotes the development of breast cancer by regulating microRNA-1296-5p/tripartite motif containing 14 axis.	hsa_circ_0048764	circ_0048764 			breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circ_0048764 is up-regulated in breast cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes malignant phenotypes (proliferation, migration, invasion) and inhibits apoptosis by sponging miR-1296-5p to increase TRIM14 expression, forming a circ_0048764/miR-1296-5p/TRIM14 ceRNA axis."	0.7415
34788230	Aging	2021	Circular RNA CELF1 drives immunosuppression and anti-PD1 therapy resistance in non-small cell lung cancer via the miR-491-5p/EGFR axis.		circ_CELF1	hsa_circ_CELF1	CELF1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_CELF1 is up-regulated in NSCLC tissues and promotes malignant phenotypes (proliferation, cell-cycle progression, migration/invasion, tumor growth/metastasis). It functions mainly as a ceRNA by sponging miR-491-5p to upregulate EGFR, and is associated with reduced CD8+ T-cell infiltration and resistance to anti-PD-1 therapy."	0.8596
34788492	Journal of clinical laboratory analysis	2022	The potential role of hsa_circ_0001079 in androgenetic alopecia via sponging hsa-miR-136-5p.	hsa_circ_0001079		hsa_circ_STK39	STK39	Androgenetic alopecia 	MONDO:0005339	androgenetic alopecia	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001079 is significantly up-regulated in hair follicles from androgenetic alopecia patients and shows diagnostic potential by ROC analysis. Mechanistically, it is predicted to sponge hsa-miR-136-5p, thereby relieving miRNA repression of Wnt5A and potentially inhibiting hair follicle growth."	0.6709
34789242	Respiratory research	2021	Knockdown of circFOXO3 ameliorates cigarette smoke-induced lung injury in mice.		circFOXO3 	mmu_circ_FOXO3	FOXO3	Chronic obstructive pulmonary disease 	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR; ISH	"circFOXO3 is up-regulated in cigarette smoke_exposed mouse lungs and CSE-treated MLE12 cells and is mainly cytoplasmic. It promotes lung inflammation by sponging miR-214-3p to increase IKK-beta expression, thereby activating NF-kappaB signaling and increasing inflammatory cytokines (e.g., CXCL1, IL-6); circFOXO3 knockdown ameliorates CS-induced lung injury/inflammation."	0.7223
34789260	Cancer cell international	2021	CircTP63 promotes cell proliferation and invasion by regulating EZH2 via sponging miR-217 in gallbladder cancer.	hsa_circ_0068515	CircTP63 	hsa_circ_TP63	TP63	gallbladder cancer 	MONDO:0005411	gallbladder cancer	up-regulated	RT-qPCR	"circTP63 is up-regulated in gallbladder cancer tissues and cell lines and promotes proliferation, cell-cycle progression, migration/invasion and EMT. It acts as a ceRNA by sponging miR-217 to increase EZH2 expression, thereby facilitating tumor progression; high circTP63 predicts poorer overall survival and is associated with lymph node metastasis."	0.8227
34789263	Journal of translational medicine	2021	The inhibition of circular RNA circNOLC1 by propofol/STAT3 attenuates breast cancer stem cells function via miR-365a-3p/STAT3 signaling.		circNOLC1	hsa_circ_NOLC1		breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circNOLC1 is up-regulated in breast cancer and promotes proliferation, migration/invasion, EMT, and cancer stem cell properties. Mechanistically, it acts as a ceRNA for miR-365a-3p to increase STAT3, and propofol suppresses circNOLC1 via inhibiting STAT3 recruitment to the circNOLC1 promoter, with circNOLC1 overexpression rescuing propofol¡¯s anti-tumor effects in vitro and in vivo."	0.7589
34789275	Journal of nanobiotechnology	2021	A nanodrug system overexpressed circRNA_0001805 alleviates nonalcoholic fatty liver disease via miR-106a-5p/miR-320a and ABCA1/CPT1 axis.	hsa_circ_0001805	circRNA_0001805			nonalcoholic fatty liver disease 	MONDO:0013209	metabolic dysfunction-associated steatotic liver disease	down-regulated	RT-qPCR	"circRNA_0001805 is down-regulated in NAFLD (patients, FFA-treated primary hepatocytes, and HFD-fed mice). Its overexpression protects against hepatic lipid accumulation and inflammation via a ceRNA mechanism that sponges miR-106a-5p and miR-320a, thereby increasing ABCA1 and CPT1 and suppressing NF-kappaB signaling."	0.5607
34789310	Journal of ovarian research	2021	CircSETDB1 knockdown inhibits the malignant progression of serous ovarian cancer through miR-129-3p-dependent regulation of MAP3K3.			hsa_circ_SETDB1	SETDB1	serous ovarian cancer 	MONDO:0005211	ovarian serous adenocarcinoma	up-regulated	RT-qPCR	"circSETDB1 is up-regulated in serous ovarian cancer and functions as an oncogenic circRNA. It sponges miR-129-3p to increase MAP3K3 expression, thereby promoting proliferation, migration and invasion and inhibiting apoptosis; circSETDB1 knockdown suppresses tumor growth in vivo."	0.8006
34790286	Oxidative medicine and cellular longevity	2021	Circular RNA circPHKA2 Relieves OGD-Induced Human Brain Microvascular Endothelial Cell Injuries through Competitively Binding miR-574-5p to Modulate SOD2.	hsa_circ_0090002	circPHKA2	hsa_circ_PHKA2	PHKA2	acute ischemic stroke 	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR	"circPHKA2 is downregulated in AIS patient blood and in OGD-treated HBMEC. Functionally, circPHKA2 overexpression protects endothelial cells from OGD injury by sponging miR-574-5p to upregulate SOD2, enhancing proliferation/migration/tube formation and reducing apoptosis, ER stress, and oxidative stress."	0.842
34791795	Journal of cellular and molecular medicine	2021	Circular RNA-associated ceRNA network involved in HIF-1 signalling in triple-negative breast cancer: circ_0047303 as a potential key regulator.	hsa_circ_0047303	circ_0047303 	hsa_circ_ZNF521	ZNF521	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0047303 is significantly upregulated in TNBC and acts as a ceRNA hub predicted to sponge tumor-suppressive miRNAs (notably miR-183-5p and miR-145-5p), thereby associating with increased expression of HIF-1A/EIF4E2/VEGFA and HIF-1 signaling-related angiogenesis. It shows diagnostic potential (AUC=0.7) and high expression is linked to shorter disease-free survival and more advanced clinicopathological features."	0.636
34795497	Journal of inflammation research	2021	circ_TGFBR2 Inhibits Vascular Smooth Muscle Cells Phenotypic Switch and Suppresses Aortic Dissection Progression by Sponging miR-29a.		circ_TGFBR2 	hsa_circ_TGFBR2	TGFBR2	Aortic dissection 	MONDO:0019625	familial thoracic aortic aneurysm and aortic dissection	down-regulated	RT-qPCR; ISH	"circ_TGFBR2 is down-regulated in aortic dissection tissues and AD-VSMCs. It suppresses VSMC proliferation/migration and phenotypic switching by acting as a ceRNA that sponges miR-29a to regulate KLF4, and its overexpression inhibits AD progression in a BAPN-induced rat model."	0.8465
34796151	Frontiers in pediatrics	2021	Microarray and Bioinformatics Analysis of Circular RNA Differential Expression in Newborns With Acute Respiratory Distress Syndrome.	hsa_circ_0005389		hsa_circ_SLC38A10	SLC38A10	Neonatal Acute Respiratory Distress Syndrome 	MONDO:0700081	newborn respiratory distress syndrome	up-regulated	RT-qPCR; Microarray	"hsa_circ_0005389 is up-regulated in NARDS/ARDS newborn plasma and its differential expression was supported by RT-qPCR consistent with the microarray. The study predicts a circRNA_miRNA_mRNA network and suggests potential involvement in inflammation/stress-related processes, but the specific mechanism for this circRNA was not experimentally validated."	0.5135
34796151	Frontiers in pediatrics	2021	Microarray and Bioinformatics Analysis of Circular RNA Differential Expression in Newborns With Acute Respiratory Distress Syndrome.	hsa_circ_0000367		hsa_circ_SIAE	SIAE	Neonatal Acute Respiratory Distress Syndrome 	MONDO:0700081	newborn respiratory distress syndrome	up-regulated	RT-qPCR; Microarray	hsa_circ_0000367 is identified as up-regulated in NARDS/ARDS newborn plasma by microarray and was among the circRNAs whose expression drift was supported by RT-qPCR. Its downstream miRNA/mRNA interactions were predicted bioinformatically but not experimentally validated.	0.5135
34796151	Frontiers in pediatrics	2021	Microarray and Bioinformatics Analysis of Circular RNA Differential Expression in Newborns With Acute Respiratory Distress Syndrome.	hsa_circ_0006608		hsa_circ_PFKP	PFKP	Neonatal Acute Respiratory Distress Syndrome 	MONDO:0700081	newborn respiratory distress syndrome	down-regulated	RT-qPCR; Microarray	"hsa_circ_0006608 is down-regulated in NARDS/ARDS newborn plasma and its differential expression drift was supported by RT-qPCR in an independent set of blood samples. Predicted miRNA/mRNA interactions were generated by bioinformatics, but no direct mechanistic validation was performed for this circRNA."	0.5135
34796151	Frontiers in pediatrics	2021	Microarray and Bioinformatics Analysis of Circular RNA Differential Expression in Newborns With Acute Respiratory Distress Syndrome.	hsa_circ_0058495		hsa_circ_RHBDD1	RHBDD1	Neonatal Acute Respiratory Distress Syndrome 	MONDO:0700081	newborn respiratory distress syndrome	down-regulated	Microarray	"hsa_circ_0058495 was identified by microarray as down-regulated in NARDS newborn plasma and was included in bioinformatic prediction of a circRNA_miRNA_mRNA network. It was not validated by RT-qPCR in this study due to primer/design limitations, so evidence remains microarray-based."	0.4685
34796151	Frontiers in pediatrics	2021	Microarray and Bioinformatics Analysis of Circular RNA Differential Expression in Newborns With Acute Respiratory Distress Syndrome.	hsa_circ_0059571		hsa_circ_RALGAPA2	RALGAPA2	Neonatal Acute Respiratory Distress Syndrome 	MONDO:0700081	newborn respiratory distress syndrome	up-regulated	Microarray	"hsa_circ_0059571 was identified by microarray as up-regulated in NARDS newborn plasma and was included in bioinformatic prediction of a circRNA_miRNA_mRNA network. It was not validated by RT-qPCR in this study, so evidence remains microarray-based."	0.4685
34798782	Cancer control : journal of the Moffitt Cancer Center	2021	Hsa_circ_0013290 Acts as Cancer-Promoting Gene in Hepatocellular Carcinoma.	hsa_circ_0013290	circAGL	hsa_circ_AGL	AGL	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"hsa_circ_0013290 (circAGL), derived from AGL, is up-regulated in HCC cell lines and mainly localized in the cytoplasm. It promotes invasion and migration and inhibits apoptosis in vitro; knockdown suppresses tumor growth in a cell line-derived xenograft model. Mechanistic work is limited to bioinformatics prediction of binding partners and observed changes in NOX4 and RRAGD after knockdown."	0.7722
34800978	BMC cancer	2021	Circular RNA hsa_circ_0043278 inhibits breast cancer progression via the miR-455-3p/EI24 signalling pathway.	hsa_circ_0043278		hsa_circ_TADA2A	TADA2A	Breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0043278 is down-regulated in breast cancer tissues and cell lines. It suppresses breast cancer progression by acting as a ceRNA sponge for miR-455-3p, thereby increasing EI24 and inhibiting NF-kappaB activity, which reduces proliferation/viability, migration, invasion, and xenograft tumor growth."	0.7699
34801043	Cancer cell international	2021	Construction of circRNA-miRNA-mRNA network and identification of novel potential biomarkers for non-small cell lung cancer.	hsa_circ_0002017	hsa_circRNA_102677	hsa_circ_CRIM1	CRIM1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	hsa_circ_0002017 is a down-regulated circRNA in NSCLC identified from GEO datasets and validated by qRT-PCR in NSCLC cell lines. It was included in the constructed circRNA-miRNA-mRNA ceRNA subnetwork with key up-regulated miRNAs (hsa-miR-767-3p/5p) and prognostic mRNAs.	0.4032
34801043	Cancer cell international	2021	Construction of circRNA-miRNA-mRNA network and identification of novel potential biomarkers for non-small cell lung cancer.	hsa_circ_0069244	hsa_circRNA_103606 	hsa_circ_LDB2	LDB2	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	hsa_circ_0069244 (circLDB2) is down-regulated in NSCLC and validated by qRT-PCR in NSCLC cell lines. It was included as a node in the study¡¯s circRNA-miRNA-mRNA ceRNA subnetwork anchored by hsa-miR-767-3p/5p and prognostic target genes.	0.4032
34801043	Cancer cell international	2021	Construction of circRNA-miRNA-mRNA network and identification of novel potential biomarkers for non-small cell lung cancer.		hsa_circ_026337			non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	hsa_circ_026337 is reported as a down-regulated circRNA in NSCLC and validated by qRT-PCR in A549 and SK-MES-1 cells. It is included in the study¡¯s circRNA-miRNA-mRNA ceRNA subnetwork together with key miRNAs (hsa-miR-767-3p/5p) and prognostic mRNAs.	0.4032
34801043	Cancer cell international	2021	Construction of circRNA-miRNA-mRNA network and identification of novel potential biomarkers for non-small cell lung cancer.	hsa_circ_0002346	hsa_circRNA_102678 	hsa_circ_CRIM1	CRIM1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	hsa_circ_0002346 (circCRIM1) is down-regulated in NSCLC and validated by qRT-PCR in A549 and SK-MES-1 cells. It is incorporated into the study¡¯s circRNA-miRNA-mRNA ceRNA subnetwork with key miRNAs (hsa-miR-767-3p/5p) and prognostic mRNAs.	0.4032
34801043	Cancer cell international	2021	Construction of circRNA-miRNA-mRNA network and identification of novel potential biomarkers for non-small cell lung cancer.	hsa_circ_0007386	hsa_circRNA_102683	hsa_circ_CRIM1	CRIM1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	hsa_circ_0007386 is down-regulated in NSCLC and validated by qRT-PCR in A549 and SK-MES-1 cells. It is part of the circRNA-miRNA-mRNA ceRNA subnetwork constructed in this study.	0.4032
34801043	Cancer cell international	2021	Construction of circRNA-miRNA-mRNA network and identification of novel potential biomarkers for non-small cell lung cancer.	hsa_circ_0008234	hsa_circRNA_103415 	hsa_circ_FOXP1	FOXP1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	hsa_circ_0008234 (circFOXP1) is down-regulated in NSCLC and validated by qRT-PCR in A549 and SK-MES-1 cells. It is one of the circRNAs used to build the study¡¯s circRNA-miRNA-mRNA ceRNA subnetwork.	0.4032
34801043	Cancer cell international	2021	Construction of circRNA-miRNA-mRNA network and identification of novel potential biomarkers for non-small cell lung cancer.	hsa_circ_0006857	hsa_circRNA_100850	hsa_circ_PACS1	PACS1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	hsa_circ_0006857 is down-regulated in NSCLC and validated by qRT-PCR in A549 and SK-MES-1 cells. It is included among the circRNAs forming the circRNA-miRNA-mRNA ceRNA subnetwork reported by the study.	0.4032
34801077	Diabetology & metabolic syndrome	2021	"CircSMAD4 alleviates high glucose-induced inflammation, extracellular matrix deposition and apoptosis in mouse glomerulus mesangial cells by relieving miR-377-3p-mediated BMP7 inhibition."	mmu_circ_0000894	circSMAD4	mmu_circ_SMAD4	SMAD4	Diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	down-regulated	RT-qPCR	"In DN models, circSMAD4 is down-regulated and functions as a protective circRNA. It sponges miR-377-3p to relieve repression of BMP7, thereby reducing high glucose-induced inflammation, ECM deposition/fibrosis markers, and apoptosis in SV40-MES13 mesangial cells."	0.6253
34803498	International journal of biological sciences	2021	Circ-PTPDC1 promotes the Progression of Gastric Cancer through Sponging Mir-139-3p by Regulating ELK1 and Functions as a Prognostic Biomarker.	hsa_circ_0008577	circ-PTPDC1 	hsa_circ_PTPDC1	PTPDC1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circ-PTPDC1 (hsa_circ_0008577) is up-regulated in gastric cancer tissues and plasma and mainly localized in the cytoplasm. It promotes gastric cancer cell proliferation, migration, and invasion by acting as a ceRNA that sponges miR-139-3p, thereby increasing ELK1 expression, and it is associated with worse DFS/OS and potential diagnostic/prognostic value."	0.8921
34804121	Frontiers in genetics	2021	Hsa_circRNA_103124 Upregulation in Crohn's Disease Promotes Cell Proliferation and Inhibits Autophagy by Regulating the Hsa-miR-650/AKT2 Signaling Pathway.		hsa_circRNA_103124 			Crohn¡¯s disease 	MONDO:0005011	Crohn disease	up-regulated	RT-qPCR	"In Crohn¡¯s disease, hsa_circRNA_103124 is up-regulated in PBMCs and correlates positively with WBC count and fecal calprotectin. Functionally, it promotes intestinal epithelial cell proliferation and inhibits rapamycin-induced autophagy by sponging hsa-miR-650, thereby increasing AKT2 (and CDK2) and reducing TSC1/LC3B."	0.6815
34804124	Frontiers in genetics	2021	Transcriptomic and Proteomic Profiling of Human Stable and Unstable Carotid Atherosclerotic Plaques.		hsacirc_000411 	hsa_circ_SH3GLB1	SH3GLB1	atherosclerosis 	MONDO:0005311	atherosclerosis	down-regulated	RNA-seq	"In human carotid atherosclerotic plaques, hsacirc_000411 (host gene SH3GLB1) is down-regulated in unstable versus stable plaques. It was identified as a key circRNA linked to plaque stability and is predicted to act via a ceRNA mechanism by binding miR-647 and miR-4433b to influence downstream target genes."	0.1768
34805186	Frontiers in cell and developmental biology	2021	Competitive Endogenous RNA Landscape in Epstein-Barr Virus Associated Nasopharyngeal Carcinoma.	hsa_circ_0002538				Nasopharyngeal Carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RNA-seq	"hsa_circ_0002538 is computationally identified as up-regulated in NPC cell lines vs non-cancer NP69 and is predicted to sponge miR-589-5p, consistent with a ceRNA axis potentially associated with RPGR upregulation. This axis is proposed as a source of downstream expression abnormalities but lacks experimental validation beyond RNA-seq and in silico prediction."	0.1768
34805186	Frontiers in cell and developmental biology	2021	Competitive Endogenous RNA Landscape in Epstein-Barr Virus Associated Nasopharyngeal Carcinoma.	hsa_circ_0027494				Nasopharyngeal Carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RNA-seq	"hsa_circ_0027494 is computationally identified as up-regulated in EBV+ vs EBV- NPC cell line comparisons and is paired with down-regulated let-7c-5p, consistent with a proposed miRNA sponge relationship. The study suggests this interaction may contribute to pathological differences between EBV subtypes of NPC, without experimental wet-lab validation."	0.1768
34805186	Frontiers in cell and developmental biology	2021	Competitive Endogenous RNA Landscape in Epstein-Barr Virus Associated Nasopharyngeal Carcinoma.	hsa_circ_0005853	hsa_circ_005853			Nasopharyngeal Carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RNA-seq	"hsa_circ_0005853 is up-regulated in EBV+ vs EBV- NPC cell line comparisons and is predicted to bind miR-1260b in a ceRNA axis that includes ZNF268 and ZNF302. The study suggests this axis may be important for NPC progression, but evidence is limited to RNA-seq-based differential expression and bioinformatic predictions."	0.1768
34805186	Frontiers in cell and developmental biology	2021	Competitive Endogenous RNA Landscape in Epstein-Barr Virus Associated Nasopharyngeal Carcinoma.	hsa_circ_0008952				Nasopharyngeal Carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RNA-seq	hsa_circ_0008952 is up-regulated in EBV+ vs EBV- NPC cell line comparisons and is predicted to bind miR-1260b in an axis associated with ZNF268 and ZNF302. The proposed role is based on RNA-seq differential expression and bioinformatic target prediction without further experimental validation.	0.1768
34805186	Frontiers in cell and developmental biology	2021	Competitive Endogenous RNA Landscape in Epstein-Barr Virus Associated Nasopharyngeal Carcinoma.	hsa_circ_0008129		hsa_circ_CDKN1B		Nasopharyngeal Carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RNA-seq	"hsa_circ_0008129 is identified as up-regulated in EBV+ vs EBV- NPC cell lines and is proposed to sponge miR-221-3p, resulting in increased CDKN1B expression as part of a ceRNA axis. The study suggests this axis may underlie pathological differences between EBV subtypes, but the evidence is computational (RNA-seq DE and target prediction) without direct experimental validation of the circRNA interaction."	0.1768
34805186	Frontiers in cell and developmental biology	2021	Competitive Endogenous RNA Landscape in Epstein-Barr Virus Associated Nasopharyngeal Carcinoma.		novel-circ-0008688			Nasopharyngeal Carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RNA-seq	novel-circ-0008688 is identified as up-regulated in EBV+ vs EBV- NPC cell line comparisons and forms predicted circRNA-miRNA pairs with miR-24-3p and miR-3074-5p. Its downstream effectors are not specified; evidence is limited to RNA-seq differential expression and bioinformatic prediction.	0.1768
34805186	Frontiers in cell and developmental biology	2021	Competitive Endogenous RNA Landscape in Epstein-Barr Virus Associated Nasopharyngeal Carcinoma.	hsa_circ_0001790				Nasopharyngeal Carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RNA-seq	hsa_circ_0001790 is identified as up-regulated in EBV+ vs EBV- NPC cell line comparisons and is predicted to interact with miR-24-3p and miR-3074-5p. The study does not specify downstream mRNA targets for this circRNA; evidence is computational only.	0.1768
34805186	Frontiers in cell and developmental biology	2021	Competitive Endogenous RNA Landscape in Epstein-Barr Virus Associated Nasopharyngeal Carcinoma.	hsa_circ_0055113				Nasopharyngeal Carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	down-regulated	RNA-seq	hsa_circ_0055113 is identified as down-regulated in EBV+ vs EBV- NPC cell line comparisons and is paired with up-regulated miR-449c-5p. The study does not provide downstream mRNA targets for this circRNA; evidence is computational (RNA-seq DE and in silico pairing).	0.1768
34805186	Frontiers in cell and developmental biology	2021	Competitive Endogenous RNA Landscape in Epstein-Barr Virus Associated Nasopharyngeal Carcinoma.	hsa_circ_0078510				Nasopharyngeal Carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	down-regulated	RNA-seq	hsa_circ_0078510 is identified as down-regulated in EBV+ vs EBV- NPC cell line comparisons and is paired with up-regulated miR-497-5p. The study does not define downstream mRNA targets for this circRNA; evidence is limited to RNA-seq differential expression and bioinformatic pairing.	0.1768
34806315	Thoracic cancer	2022	Construction of a circular RNA-microRNA-messenger RNA regulatory network of hsa_circ_0043256 in lung cancer by integrated analysis.	hsa_circ_0043256		hsa_circ_ACACA	ACACA	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0043256 is significantly down-regulated in NSCLC tissues and cell lines. Overexpression inhibits NSCLC cell proliferation and cell-cycle progression in vitro, and a predicted ceRNA network was constructed linking hsa_circ_0043256 to miR-1183-5p/miR-1303-5p/miR-512-5p and downstream mRNAs (including hub genes such as BIRC5 and CCNA2)."	0.6777
34811346	Cell death discovery	2021	CircMYOF triggers progression and facilitates glycolysis via the VEGFA/PI3K/AKT axis by absorbing miR-4739 in pancreatic ductal adenocarcinoma.	hsa_circ_0005392	circMYOF	hsa_circ_MYOF	MYOF	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circMYOF is upregulated in pancreatic ductal adenocarcinoma and promotes tumor cell proliferation and migratory ability. It mainly localizes to the cytoplasm and acts as a ceRNA that sponges miR-4739, thereby increasing VEGFA and activating PI3K/AKT signaling to enhance glycolysis."	0.8511
34811353	Cell death discovery	2021	circKDM4C enhances bladder cancer invasion and metastasis through miR-200bc-3p/ZEB1 axis.	hsa_circ_0001839	circKDM4C	hsa_circ_KDM4C	KDM4C	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; RNA-seq	"circKDM4C is up-regulated in bladder cancer tissues and cell lines and promotes migration, invasion, and metastasis. It primarily localizes to the cytoplasm and acts as a ceRNA by sponging miR-200b-3p/miR-200c-3p, thereby increasing ZEB1 expression and promoting EMT-like mesenchymal features."	0.8382
34811815	Journal of clinical laboratory analysis	2022	Circ_0000463 contributes to the progression and glutamine metabolism of non-small-cell lung cancer by targeting miR-924/SLC1A5 signaling.	hsa_circ_0000463		hsa_circ_EP400NL	EP400NL	non_small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0000463 is up-regulated in NSCLC tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion/EMT) while inhibiting apoptosis. Mechanistically, it functions as a ceRNA by sponging miR-924 to increase SLC1A5 expression, thereby enhancing glutamine metabolism and supporting tumor growth in a cell line-derived xenograft model."	0.8299
34820154	PeerJ	2021	Circ_0030235 knockdown protects H9c2 cells against OGD/R-induced injury via regulation of miR-526b.	mmu_circ_0030235				acute myocardial infarction 	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR	"Circ_0030235 is up-regulated in the OGD/R H9c2 myocardial injury model. Silencing circ_0030235 protects cells by reducing apoptosis, ROS and mitochondrial injury, by sponging miR-526b and thereby restoring PI3K/AKT and MEK/ERK pathway activity."	0.5607
34820156	PeerJ	2021	Circular RNA RBM33 contributes to extracellular matrix degradation via miR-4268/EPHB2 axis in abdominal aortic aneurysm.		circRBM33 	hsa_circ_RBM33	RBM33	abdominal aortic aneurysm 	MONDO:0005350	abdominal aortic aneurysm	up-regulated	RT-qPCR; RNA-seq	"circRBM33 is up-regulated in abdominal aortic aneurysm tissues and Ang II-induced VSMCs. Functionally, circRBM33 overexpression promotes ECM degradation by increasing MMP-2 and decreasing TIMP-1, mechanistically via sponging miR-4268 to upregulate EPHB2 (circRBM33/miR-4268/EPHB2 axis)."	0.7519
34820383	Frontiers in cell and developmental biology	2021	Circular RNA Expression Profiles and Bioinformatic Analysis in Mouse Models of Obstructive Sleep Apnea-Induced Cardiac Injury: Novel Insights Into Pathogenesis.		mmu_circRNA_014309 			obstructive sleep apnea 	MONDO:0007147	obstructive sleep apnea syndrome	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_014309 was down-regulated in CIH-induced cardiac injury in mice. The study predicted a circRNA_miRNA_mRNA ceRNA network for mmu_circ_014309 using TargetScan/miRanda, but did not experimentally validate the mechanistic interactions."	0.3858
34820383	Frontiers in cell and developmental biology	2021	Circular RNA Expression Profiles and Bioinformatic Analysis in Mouse Models of Obstructive Sleep Apnea-Induced Cardiac Injury: Novel Insights Into Pathogenesis.		mmu_circRNA_21856 			obstructive sleep apnea 	MONDO:0007147	obstructive sleep apnea syndrome	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_21856 was down-regulated in CIH-induced cardiac injury in mice. The study computationally predicted that it may bind (sponge) miR-326_5p and built a circRNA_miRNA_mRNA ceRNA network, without further experimental validation of binding or downstream effects."	0.3858
34820403	Frontiers in medicine	2021	Novel CircRNAs in Hub ceRNA Axis Regulate Gastric Cancer Prognosis and Microenvironment.	hsa_circ_0061695	circRNA DYRK1A_017 	hsa_circ_DYRK1A	DYRK1A	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	Microarray	"hsa_circ_0061695 (also referred to as circRNA DYRK1A_017) is upregulated in gastric cancer and is proposed as part of a hub ceRNA axis with miR-6512-3p/miR-6720-5p and VCAN. This axis is linked to pro-tumor pathways (e.g., EMT, TNFalpha-NFkappaB signaling, angiogenesis) and an immunosuppressive tumor microenvironment."	0.1768
34820403	Frontiers in medicine	2021	Novel CircRNAs in Hub ceRNA Axis Regulate Gastric Cancer Prognosis and Microenvironment.	hsa_circ_0091994	circRNA FLNA_118 	hsa_circ_FLNA	FLNA	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	Microarray	hsa_circ_0091994 (also referred to as circRNA FLNA_118) is upregulated in gastric cancer and is proposed as part of a hub ceRNA axis with miR-6512-3p/miR-6720-5p and VCAN. This axis is associated with pro-tumor pathways and an immunosuppressive tumor microenvironment.	0.1768
34824999	International journal of genomics	2021	Identification of the circRNA-miRNA-mRNA Regulatory Network in Bladder Cancer by Bioinformatics Analysis.		hsa_circRNA_104700			bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	Microarray	Identified as a hub circRNA in the circRNA-miRNA-mRNA network for bladder cancer and reported to be up-regulated in tumor samples based on expression profile datasets.	0.1768
34824999	International journal of genomics	2021	Identification of the circRNA-miRNA-mRNA Regulatory Network in Bladder Cancer by Bioinformatics Analysis.		hsa_circRNA_101902			bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	Microarray	Identified as a central/hub circRNA in bladder cancer and found up-regulated in tumor samples in the dataset-derived expression profiles.	0.1768
34824999	International journal of genomics	2021	Identification of the circRNA-miRNA-mRNA Regulatory Network in Bladder Cancer by Bioinformatics Analysis.		hsa_circRNA_100213			bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	Microarray	This hub circRNA was reported as up-regulated in bladder cancer tumor samples based on differential expression profiling used to build the regulatory network.	0.1768
34824999	International journal of genomics	2021	Identification of the circRNA-miRNA-mRNA Regulatory Network in Bladder Cancer by Bioinformatics Analysis.		hsa_circRNA_100062			bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	Microarray	Reported as an up-regulated central circRNA in bladder cancer tumors from the analyzed expression datasets used to construct the network.	0.1768
34824999	International journal of genomics	2021	Identification of the circRNA-miRNA-mRNA Regulatory Network in Bladder Cancer by Bioinformatics Analysis.		hsa_circRNA_102682 			bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	Microarray	This circRNA was identified as a hub/central circRNA in the constructed circRNA-miRNA-mRNA network for bladder cancer and was up-regulated in tumor samples; it was highlighted as targeting the maximum number of miRNAs in the network.	0.1768
34824999	International journal of genomics	2021	Identification of the circRNA-miRNA-mRNA Regulatory Network in Bladder Cancer by Bioinformatics Analysis.		hsa_circRNA_001059			bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	Microarray	This hub circRNA showed increased expression in bladder cancer tumor samples in the analyzed expression profiles.	0.1768
34824999	International journal of genomics	2021	Identification of the circRNA-miRNA-mRNA Regulatory Network in Bladder Cancer by Bioinformatics Analysis.		hsa_circRNA_104433			bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	Microarray	A central circRNA that is up-regulated in bladder cancer tumor samples according to the differential expression profiling used in this study.	0.1768
34824999	International journal of genomics	2021	Identification of the circRNA-miRNA-mRNA Regulatory Network in Bladder Cancer by Bioinformatics Analysis.		hsa_circRNA_100722 			bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	Microarray	"This hub circRNA was up-regulated in bladder cancer and was placed in a predicted ceRNA network where it binds has-miR-548ba, which targets CDCA4."	0.1768
34824999	International journal of genomics	2021	Identification of the circRNA-miRNA-mRNA Regulatory Network in Bladder Cancer by Bioinformatics Analysis.		hsa_circRNA_104435			bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	Microarray	Reported as a central circRNA whose expression is increased in bladder cancer tumor samples based on expression profiling.	0.1768
34824999	International journal of genomics	2021	Identification of the circRNA-miRNA-mRNA Regulatory Network in Bladder Cancer by Bioinformatics Analysis.		hsa_circRNA_104387			bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	Microarray	A central circRNA found up-regulated in bladder cancer tumor samples in this study¡¯s expression-profile comparison.	0.1768
34824999	International journal of genomics	2021	Identification of the circRNA-miRNA-mRNA Regulatory Network in Bladder Cancer by Bioinformatics Analysis.		hsa_circRNA_105055 			bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	Microarray	This hub circRNA is down-regulated in bladder cancer tumors and was placed in a predicted ceRNA network involving has-miR-944 and the mRNA GATA6; it was suggested to act as a suppressor in BCa.	0.1768
34824999	International journal of genomics	2021	Identification of the circRNA-miRNA-mRNA Regulatory Network in Bladder Cancer by Bioinformatics Analysis.		hsa_circRNA_101525			bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	Microarray	A hub circRNA reported to be down-regulated in bladder cancer tumor samples based on the analyzed expression datasets.	0.1768
34824999	International journal of genomics	2021	Identification of the circRNA-miRNA-mRNA Regulatory Network in Bladder Cancer by Bioinformatics Analysis.		hsa_circRNA_104194			bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	Microarray	This central circRNA was found down-regulated in bladder cancer tumor samples in the expression profile comparison.	0.1768
34824999	International journal of genomics	2021	Identification of the circRNA-miRNA-mRNA Regulatory Network in Bladder Cancer by Bioinformatics Analysis.		hsa_circRNA_104703			bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	Microarray	A hub circRNA reported to be down-regulated in bladder cancer tumor samples based on differential expression analysis of public datasets.	0.1768
34824999	International journal of genomics	2021	Identification of the circRNA-miRNA-mRNA Regulatory Network in Bladder Cancer by Bioinformatics Analysis.		hsa_circRNA_102002 			bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	Microarray	"This hub circRNA is down-regulated in bladder cancer and was included in a predicted ceRNA network where it binds has-miR-372, connected to the target gene LATS2."	0.1768
34824999	International journal of genomics	2021	Identification of the circRNA-miRNA-mRNA Regulatory Network in Bladder Cancer by Bioinformatics Analysis.		hsa_circRNA_101308			bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	Microarray	A central circRNA reported as down-regulated in bladder cancer tumor samples in this study¡¯s differential expression analysis.	0.1768
34824999	International journal of genomics	2021	Identification of the circRNA-miRNA-mRNA Regulatory Network in Bladder Cancer by Bioinformatics Analysis.		hsa_circRNA_104503 			bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	Microarray	This hub circRNA is down-regulated in bladder cancer and was highlighted as highly connected in the circRNA-miRNA-mRNA network; it was linked to has-miR-372 and the target gene LATS2 in the predicted ceRNA relationships.	0.1768
34824999	International journal of genomics	2021	Identification of the circRNA-miRNA-mRNA Regulatory Network in Bladder Cancer by Bioinformatics Analysis.		hsa_circRNA_103890			bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	Microarray	A central circRNA reported to be down-regulated in bladder cancer tumor samples based on analysis of public expression datasets.	0.1768
34825467	The Kaohsiung journal of medical sciences	2022	Circular RNA circ_0023404 serves as a miR-636 sponge to promote malignant behaviors in cervical cancer cells through upregulation of CYP2S1.	hsa_circ_0023404		hsa_circ_RNF121	RNF121	cervical cancer	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ_0023404 is up-regulated in cervical cancer tissues/cells and promotes malignant phenotypes (proliferation, migration, invasion) while inhibiting apoptosis. It functions as a ceRNA by sponging miR-636 to derepress CYP2S1, forming the circ_0023404/miR-636/CYP2S1 axis."	0.7595
34825849	Technology in cancer research & treatment	2021	Construction of a circRNA-miRNA-mRNA Regulated Pathway Involved in EGFR-TKI Lung Adenocarcinoma Resistance.	hsa_circ_0007312				lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	circ-0007312 (hsa_circ_0007312) is up-regulated in EGFR-TKI-resistant PC9/ER lung adenocarcinoma cells and is proposed to function in a ceRNA network by interacting with miR-764 to affect MAPK1. It is detectable in patient plasma and may serve as a disease progression biomarker related to EGFR-TKI resistance.	0.5135
34825849	Technology in cancer research & treatment	2021	Construction of a circRNA-miRNA-mRNA Regulated Pathway Involved in EGFR-TKI Lung Adenocarcinoma Resistance.	hsa_circ_0003748				lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	circ-0003748 (hsa_circ_0003748) is up-regulated in EGFR-TKI-resistant PC9/ER cells and is proposed to act in a ceRNA axis by interacting with miR-628 to influence MAPK1. It is part of a circRNA-miRNA-mRNA network implicated in EGFR-TKI resistance.	0.2465
34825849	Technology in cancer research & treatment	2021	Construction of a circRNA-miRNA-mRNA Regulated Pathway Involved in EGFR-TKI Lung Adenocarcinoma Resistance.	hsa_circ_0001398				lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	circ-0001398 (hsa_circ_0001398) is up-regulated in EGFR-TKI-resistant PC9/ER cells and is proposed to act in a ceRNA axis by interacting with miR-628 to influence MAPK1. It is part of a circRNA-miRNA-mRNA network implicated in EGFR-TKI resistance.	0.2465
34828307	Genes	2021	Circ_0092367 Inhibits EMT and Gemcitabine Resistance in Pancreatic Cancer via Regulating the miR-1206/ESRP1 Axis.	hsa_circ_0092367		hsa_circ_SNORD116-14		pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	down-regulated	RT-qPCR	"circ_0092367 is down-regulated in pancreatic cancer and acts as a tumor-suppressive circRNA that inhibits EMT and invasion while increasing gemcitabine sensitivity. Mechanistically, it localizes mainly in the cytoplasm and sponges miR-1206 to relieve repression of ESRP1, thereby reducing chemoresistance; higher circ_0092367 expression correlates with better patient survival."	0.8025
34828435	Genes	2021	CircNFIC Balances Inflammation and Apoptosis by Sponging miR-30e-3p and Regulating DENND1B Expression.	gga_circ_0002001	circNFIC 	gga_circ_NFIC	NFIC	chicken coccidiosis 	MONDO:1011186	"scoliosis, chicken"	up-regulated	RT-qPCR	"In chicken macrophages and coccidia-infected chicken tissues, circNFIC is up-regulated and promotes inflammatory cytokine expression and apoptosis markers. Mechanistically, it sponges miR-30e-3p to de-repress DENND1B, contributing to inflammation/apoptosis, potentially via NF-kappaB signaling."	0.7657
34830863	Cancers	2021	Tumor Suppressive Circular RNA-102450: Development of a Novel Diagnostic Procedure for Lymph Node Metastasis from Oral Cancer.		circRNA-102450	hsa_circ_LDLR		oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	"circRNA-102450 is down-regulated in OSCC cells and acts as a tumor suppressor. Its overexpression inhibits proliferation, migration and invasion, and it directly binds to and down-regulates miR-1178. In preoperative plasma liquid biopsy, low circRNA-102450 is associated with regional lymph node metastasis, supporting its potential diagnostic value for RLNM prediction."	0.8347
34837683	Cell journal	2021	Circular RNA circ_0000517 Facilitates The Growth and Metastasis of Non-Small Cell Lung Cancer by Sponging miR-326/miR-330-5p.	hsa_circ_0000517		hsa_circ_RPPH1	RPPH1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0000517 is up-regulated in NSCLC tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation and metastatic behaviors while inhibiting apoptosis by sponging miR-326 and miR-330-5p, thereby increasing MMP2 expression."	0.8632
34837947	BMC anesthesiology	2021	Circ_MUC16 attenuates the effects of Propofol to promote the aggressive behaviors of ovarian cancer by mediating the miR-1182/S100B signaling pathway.	hsa_circ_0049116	circ_MUC16 	hsa_circ_MUC16	MUC16	ovarian cancer	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circ_MUC16 is up-regulated in ovarian cancer tissues/cell lines and mainly localizes to the cytoplasm. It attenuates Propofol¡¯s anti-tumor effects by sponging miR-1182 and thereby increasing S100B, promoting proliferation, glycolysis, migration, invasion, and tumor growth."	0.7983
34838011	BMC medical genomics	2021	The circular RNA hsa_circ_000780 as a potential molecular diagnostic target for gastric cancer.	hsa_circ_000780		hsa_circ_FAM107B	FAM107B	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_000780 (host gene FAM107B) is significantly down-regulated in gastric cancer tissues and is also decreased in gastric fluid, supporting its potential as a noninvasive biomarker for early GC screening. Predicted miRNA partners include hsa_miRNA_522-3p, hsa_miRNA_381-3p, hsa_miRNA_300 and hsa_miRNA_15a-3p, but mechanistic interactions were not experimentally validated."	0.585
34838012	Cancer cell international	2021	PESV represses non-small cell lung cancer cell malignancy through circ_0016760 under hypoxia.	hsa_circ_0016760		hsa_circ_SNAP47	SNAP47	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0016760 (from host gene SNAP47) is up-regulated in NSCLC tissues/cells and promotes hypoxia-associated malignant phenotypes (migration, invasion, proliferation) and angiogenesis/tube formation. Mechanistically, it sponges miR-29b, thereby increasing HIF1A expression; PESV suppresses NSCLC malignancy under hypoxia partly by downregulating circ_0016760, and circ_0016760 overexpression rescues these inhibitory effects in vitro and in xenografts."	0.7371
34838121	Journal of hematology & oncology	2021	Amplification of spatially isolated adenosine pathway by tumor-macrophage interaction induces anti-PD1 resistance in hepatocellular carcinoma.	hsa_circ_0001663	circTMEM181 	hsa_circ_TMEM181	TMEM181	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circTMEM181 is up-regulated in HCC, especially in anti-PD1-resistant patients, and high expression predicts poor prognosis. HCC cells secrete exosomal circTMEM181, which sponges miR-488-3p in macrophages to increase CD39 (ENTPD1), cooperating with tumor-cell CD73 to activate the ATP_adenosine pathway, suppress CD8+ T cell function, and drive anti-PD1 resistance."	0.8652
34839824	World journal of surgical oncology	2021	Circular RNA circVAPA contributes to non-small-cell lung cancer progression via miR-342-3p-dependent regulation of ZEB2.	hsa_circ_0006990	circVAPA	hsa_circ_VAPA	VAPA	non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circVAPA is upregulated in NSCLC tissues/cell lines and promotes malignant phenotypes (proliferation, migration/invasion, EMT) while inhibiting apoptosis. Mechanistically, it sponges miR-342-3p to increase ZEB2 expression, and its knockdown suppresses xenograft tumor growth; high circVAPA correlates with poor prognosis and shows serum diagnostic potential."	0.8229
34841662	Clinical and translational medicine	2021	Hsa_circ_0001666 suppresses the progression of colorectal cancer through the miR-576-5p/PCDH10 axis.	hsa_circ_0001666		hsa_circ_FAM120B	FAM120B	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	"In colorectal cancer, hsa_circ_0001666 is down-regulated and functions as a tumor suppressor. It sponges miR-576-5p to de-repress PCDH10, thereby inhibiting Wnt/beta-catenin signaling, EMT/stemness, proliferation and metastasis while promoting apoptosis. Higher expression is associated with better patient survival."	0.8748
34844614	Cancer cell international	2021	The circular RNA circSLC7A11 functions as a mir-330-3p sponge to accelerate hepatocellular carcinoma progression by regulating cyclin-dependent kinase 1 expression.	hsa_circ_0070975	circSLC7A11	hsa_circ_SLC7A11	SLC7A11	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Northern Blot; RNA-seq	"circSLC7A11 (hsa_circ_0070975) is up-regulated in HCC and mainly localized in the cytoplasm. It promotes HCC proliferation and metastasis by sponging miR-330-3p and thereby increasing CDK1 expression, and high circSLC7A11 levels indicate worse patient prognosis."	0.8933
34845670	"Reproductive sciences (Thousand Oaks, Calif.)"	2022	"Upregulation of circRNA hsa_circ_0008726 in Pre-eclampsia Inhibits Trophoblast Migration, Invasion, and EMT by Regulating miR-345-3p/RYBP Axis."	hsa_circ_0008726				pre-eclampsia 	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR; Microarray	"In pre-eclampsia placentas, circ_0008726 is up-regulated and acts predominantly in the cytoplasm. It suppresses trophoblast migration, invasion, and EMT by sponging miR-345-3p and thereby increasing RYBP expression (circ_0008726/miR-345-3p/RYBP axis)."	0.7974
34845750	Journal of clinical laboratory analysis	2022	CircSamd4: A novel biomarker for predicting vascular calcification.		circSamd4a 	hsa_circ_Samd4a	Samd4a	vascular calcification 	MONDO:0005311	atherosclerosis	down-regulated	RT-qPCR	"circSamd4a is significantly downregulated in calcified HAECs, calcified mouse aorta, and in plasma from patients with VC/CAC. Its plasma level is an independent risk factor and negatively correlates with coronary artery calcium score, showing diagnostic value (AUC 0.81) as a biomarker for vascular calcification."	0.6032
34847936	Reproductive biology and endocrinology : RB&E	2021	CircCRIM1 promotes ovarian cancer progression by working as ceRNAs of CRIM1 and targeting miR-383-5p/ZEB2 axis.	hsa_circ_0002346	circCRIM1	hsa_circ_CRIM1	CRIM1	ovarian cancer	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"CircCRIM1 is up-regulated in ovarian cancer and promotes malignant phenotypes (viability/proliferation, migration, invasion) while inhibiting apoptosis, and enhances tumor growth in xenografts. Mechanistically, it acts as a ceRNA for CRIM1 via miR-145-5p and also binds miR-383-5p to increase ZEB2 expression."	0.7875
34849014	International journal of general medicine	2021	WGCNA Analysis Identifies Polycystic Ovary Syndrome-Associated Circular RNAs That Interact with RNA-Binding Proteins and Sponge miRNAs.	hsa_circ_0063309		hsa_circ_DDX17	DDX17	polycystic ovary syndrome 	MONDO:0008487	polycystic ovary syndrome	up-regulated	Microarray	"hsa_circ_0063309 is an upregulated hub circRNA in PCOS cumulus cells identified by microarray reanalysis and WGCNA. It is predicted to act as a miRNA sponge (e.g., hsa-miR-139-5p/217/346/421) to affect apoptosis/inflammation- and steroidogenesis-related targets (e.g., CASP2, FZD4, HMGCR, TAB2, PEA15, RUNX2, PAK3), and to interact with the RBP MBNL2."	0.1768
34849014	International journal of general medicine	2021	WGCNA Analysis Identifies Polycystic Ovary Syndrome-Associated Circular RNAs That Interact with RNA-Binding Proteins and Sponge miRNAs.	hsa_circ_0054275		hsa_circ_MTA3	MTA3	polycystic ovary syndrome 	MONDO:0008487	polycystic ovary syndrome	up-regulated	Microarray	"hsa_circ_0054275 is an upregulated hub circRNA in PCOS cumulus cells. It is predicted to sponge hsa-miR-139-5p and hsa-miR-217 to affect downstream genes involved in inflammation/apoptosis and steroidogenesis (e.g., CASP2, FZD4, HMGCR, TAB2, PEA15, RUNX2), and to interact with the RBP MBNL2."	0.1768
34849014	International journal of general medicine	2021	WGCNA Analysis Identifies Polycystic Ovary Syndrome-Associated Circular RNAs That Interact with RNA-Binding Proteins and Sponge miRNAs.	hsa_circ_0056196		hsa_circ_ACTR3	ACTR3	polycystic ovary syndrome 	MONDO:0008487	polycystic ovary syndrome	up-regulated	Microarray	"hsa_circ_0056196 is an upregulated hub circRNA in PCOS cumulus cells. It is predicted to modulate apoptosis/inflammation and steroidogenesis-related genes via ceRNA mechanisms (e.g., sponging hsa-miR-139-5p/217/496) and to interact with MBNL2."	0.1768
34849014	International journal of general medicine	2021	WGCNA Analysis Identifies Polycystic Ovary Syndrome-Associated Circular RNAs That Interact with RNA-Binding Proteins and Sponge miRNAs.	hsa_circ_0018108		hsa_circ_KIF5B	KIF5B	polycystic ovary syndrome 	MONDO:0008487	polycystic ovary syndrome	up-regulated	Microarray	hsa_circ_0018108 is an upregulated hub circRNA in PCOS cumulus cells. It is predicted to regulate apoptosis/inflammation and steroidogenesis-related targets via sponging hsa-miR-139-5p and hsa-miR-496 (affecting CASP2/FZD4/HMGCR) and to interact with the RBP MBNL2.	0.1768
34849014	International journal of general medicine	2021	WGCNA Analysis Identifies Polycystic Ovary Syndrome-Associated Circular RNAs That Interact with RNA-Binding Proteins and Sponge miRNAs.	hsa_circ_0070987		hsa_circ_ELF2	ELF2	polycystic ovary syndrome 	MONDO:0008487	polycystic ovary syndrome	up-regulated	Microarray	"hsa_circ_0070987 is an upregulated hub circRNA in PCOS cumulus cells. It is predicted to modulate apoptosis/inflammation and steroidogenesis-related genes (e.g., CASP2/FZD4/HMGCR) via sponging hsa-miR-139-5p, and to interact with the RBP MBNL2."	0.1768
34849014	International journal of general medicine	2021	WGCNA Analysis Identifies Polycystic Ovary Syndrome-Associated Circular RNAs That Interact with RNA-Binding Proteins and Sponge miRNAs.	hsa_circ_0099109		hsa_circ_CPSF6	CPSF6	polycystic ovary syndrome 	MONDO:0008487	polycystic ovary syndrome	up-regulated	Microarray	"hsa_circ_0099109 is an upregulated hub circRNA in PCOS cumulus cells predicted to bind the RNA-binding protein RBPMS, suggesting a circRNA/RBP regulatory role in PCOS pathogenesis."	0.1768
34850570	Thoracic cancer	2022	CircRNA circ_0008037 facilitates tumor growth and the Warburg effect via upregulating NUCKS1 by binding to miR-433-3p in non-small cell lung cancer.	hsa_circ_0008037		hsa_circ_UBA2	UBA2	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"In NSCLC, circ_0008037 is up-regulated and mainly localized in the cytoplasm. It promotes tumor growth, proliferation, migration/invasion and glycolytic Warburg effect by acting as a ceRNA to sponge miR-433-3p and thereby increase NUCKS1 expression; high expression is associated with worse patient prognosis."	0.8593
34852706	Bioengineered	2021	Hsa_circ_0030586 promotes epithelial-mesenchymal transition in prostate cancer via PI3K-AKT signaling.	hsa_circ_0030586	hsa_circ_003058 	hsa_circ_ABCC4	ABCC4	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0030586 is up-regulated in prostate cancer cell lines and promotes proliferation, migration, invasion, and EMT. Mechanistically, it likely sponges hsa-miR-145-3p to activate the PI3K/AKT pathway, and miR-145-3p inhibition reverses the effects of hsa_circ_0030586 knockdown."	0.7859
34852710	Bioengineered	2022	A novel circRNA-miRNA-mRNA network revealed exosomal circ-ATP10A as a biomarker for multiple myeloma angiogenesis.		circ-ATP10A	hsa_circ_ATP10A	ATP10A	multiple myeloma 	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR; RNA-seq	"This study identified serum exosomal circ-ATP10A as significantly up-regulated in multiple myeloma patients and associated it with increased angiogenesis. Mechanistically, circ-ATP10A is predicted to function as a ceRNA by sponging five miRNAs (hsa-miR-6758-3p, hsa-miR-3977, hsa-miR-6804-3p, hsa-miR-1266-3p, hsa-miR-3620-3p) to modulate pro-angiogenic targets including VEGFB, HIF1A, PDGFA and FGF. Clinically, higher circ-ATP10A indicates worse overall survival and shows prognostic performance by ROC/Kaplan_Meier analyses, with positive correlation to VEGFB protein levels and bone marrow microvessel density."	0.5734
34852711	Bioengineered	2022	Downregulated circular RNA hsa_circ_0005797 inhibits endometrial cancer by modulating microRNA-298/Catenin delta 1 signaling.	hsa_circ_0005797		hsa_circ_ATP2C1	ATP2C1	endometrial cancer 	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR	"In endometrial cancer, hsa_circ_0005797 is up-regulated and promotes proliferation, invasion, and xenograft tumor growth. Mechanistically, it functions as a ceRNA by sponging miR-298, thereby relieving repression of CTNND1 and activating the miR-298/CTNND1 axis. High expression is associated with aggressive clinicopathologic features and poor prognosis."	0.8462
34852712	Bioengineered	2021	Circular RNA circFLNA inhibits the development of bladder carcinoma through microRNA miR-216a-3p/BTG2 axis.		circFLNA 	hsa_circ_FLNA	FLNA	bladder carcinoma 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR	"circFLNA is down-regulated in bladder carcinoma tissues and cell lines. circFLNA suppresses malignant phenotypes (proliferation, migration, invasion), EMT and stemness by acting as a ceRNA that sponges miR-216a-3p, thereby releasing BTG2 expression."	0.7295
34852843	Molecular cancer	2021	CircEAF2 counteracts Epstein-Barr virus-positive diffuse large B-cell lymphoma progression via miR-BART19-3p/APC/beta-catenin axis.	hsa_circ_0066971	circEAF2	hsa_circ_EAF2	EAF2	diffuse large B-cell lymphoma 	MONDO:0018905	diffuse large B-cell lymphoma	down-regulated	RT-qPCR; RNA-seq	"circEAF2 (hsa_circ_0066971), derived from EAF2, is down-regulated in EBV+ DLBCL and acts as a tumor suppressor. It sponges EBV-encoded miR-BART19-3p to upregulate APC and decrease nuclear beta-catenin, thereby inhibiting Wnt/beta-catenin signaling, promoting apoptosis, reducing proliferation/tumor growth, and increasing epirubicin sensitivity; higher circEAF2 predicts better survival."	0.8721
34853524	Journal of inflammation research	2021	"Mesenchymal Stem Cell-Originated Exosomal Circular RNA circFBXW7 Attenuates Cell Proliferation, Migration and Inflammation of Fibroblast-Like Synoviocytes by Targeting miR-216a-3p/HDAC4 in Rheumatoid Arthritis."		circFBXW7	hsa_circ_FBXW7	FBXW7	Rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	down-regulated	RT-qPCR	"In rheumatoid arthritis, circFBXW7 is down-regulated in patient synovial tissues and serum exosomes. MSC-derived exosomal circFBXW7 suppresses RA-FLS proliferation, migration/invasion and inflammatory cytokine production and alleviates RA injury in rats by sponging miR-216a-3p to restore HDAC4 expression."	0.8327
34853631	Oxidative medicine and cellular longevity	2021	hsa_circ_0013401 Accelerates the Growth and Metastasis and Prevents Apoptosis and Autophagy of Neuroblastoma Cells by Sponging miR-195 to Release PAK2.	hsa_circ_0013401				Neuroblastoma 	MONDO:0005072	neuroblastoma	up-regulated	RT-qPCR; ISH	"In neuroblastoma, hsa_circ_0013401 is up-regulated and functions oncogenically to promote proliferation, migration/invasion, and in vivo tumor growth while suppressing apoptosis and autophagy. Mechanistically, it sponges miR-195 to de-repress PAK2 (hsa_circ_0013401/miR-195/PAK2 axis)."	0.7376
34853725	Molecular therapy. Nucleic acids	2021	circ_PTN contributes to -cisplatin resistance in glioblastoma via PI3K/AKT signaling through the miR-542-3p/PIK3R3 pathway.	hsa_circ_0003949	circ_PTN	hsa_circ_PTN	PTN	glioblastoma 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR	"circ_PTN is up-regulated in cisplatin-resistant glioblastoma cell models and promotes DDP resistance. Mechanistically, circ_PTN sponges miR-542-3p to relieve repression of PIK3R3, thereby activating PI3K/AKT signaling and reducing apoptosis under cisplatin treatment; circ_PTN knockdown sensitizes xenograft tumors to cisplatin."	0.8028
34856948	BMC cancer	2021	"Hsa_circ_0008434 regulates USP9X expression by sponging miR-6838-5p to promote gastric cancer growth, migration and invasion."	hsa_circ_0008434		hsa_circ_UQCRC2	UQCRC2	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"In gastric cancer, hsa_circ_0008434 is up-regulated and promotes proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, it functions as a ceRNA sponging miR-6838-5p to increase USP9X expression."	0.7736
34857007	BMC medical genomics	2021	The circular RNA expression profile in ovarian serous cystadenocarcinoma reveals a complex circRNA-miRNA regulatory network.			hsa_circ_DENND5B	DENND5B	ovarian serous cystadenocarcinoma	MONDO:0006046	ovarian serous cystadenocarcinoma	up-regulated	RNA-seq	"hsa_circ_DENND5B was identified from ovarian serous cystadenocarcinoma tissues and highlighted in the circRNA_miRNA network as a novel circRNA predicted to bind many ovarian cancer-related miRNAs (16), suggesting a potential miRNA-sponge role and biomarker potential."	0.1768
34857007	BMC medical genomics	2021	The circular RNA expression profile in ovarian serous cystadenocarcinoma reveals a complex circRNA-miRNA regulatory network.	hsa_circ_0003251				ovarian serous cystadenocarcinoma	MONDO:0006046	ovarian serous cystadenocarcinoma	unknown	RNA-seq	"hsa_circ_0003251 was highlighted in the constructed circRNA_miRNA network as one of four potential biomarker circRNAs, predicted to bind many ovarian cancer-related miRNAs (ranked second with 14)."	0.1768
34857007	BMC medical genomics	2021	The circular RNA expression profile in ovarian serous cystadenocarcinoma reveals a complex circRNA-miRNA regulatory network.			hsa_circ_SLC44A4	SLC44A4	ovarian serous cystadenocarcinoma	MONDO:0006046	ovarian serous cystadenocarcinoma	up-regulated	RNA-seq	"hsa_circ_SLC44A4 was highlighted in the circRNA_miRNA network as enriched in tumor tissues and predicted to interact with multiple ovarian cancer-related miRNAs (8), supporting its potential as a biomarker candidate."	0.1768
34857007	BMC medical genomics	2021	The circular RNA expression profile in ovarian serous cystadenocarcinoma reveals a complex circRNA-miRNA regulatory network.			hsa_circ_AKR1E2	AKR1E2	ovarian serous cystadenocarcinoma	MONDO:0006046	ovarian serous cystadenocarcinoma	up-regulated	RNA-seq	"hsa_circ_AKR1E2 was identified as enriched in tumor tissues and predicted to target ovarian cancer-related miRNAs including miR-608 and multiple let-7 family members, supporting a putative ceRNA/miRNA-sponge role and biomarker candidacy."	0.1768
34857012	Journal of orthopaedic surgery and research	2021	Circ-ATAD1 is overexpressed in osteosarcoma (OS) and suppresses the maturation of miR-154-5p to increase cell invasion and migration.		Circ-ATAD1	hsa_circ_ATAD1	ATAD1	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"Circ-ATAD1 is up-regulated in osteosarcoma tissues and cell lines and promotes invasion and migration. Mechanistically, it localizes to both nucleus and cytoplasm, binds premature miR-154-5p, and suppresses miR-154-5p maturation, reducing mature miR-154-5p activity and affecting downstream targets such as PIWIL1."	0.6432
34858831	Frontiers in oncology	2021	Microarray Identifies a Key Carcinogenic Circular RNA 0008594 That Is Related to Non-Small-Cell Lung Cancer Development and Lymph Node Metastasis and Promotes NSCLC Progression by Regulating the miR-760-Mediated PI3K/AKT and MEK/ERK Pathways.	hsa_circ_0008594				non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0008594 is up-regulated in NSCLC and is associated with lymph node metastasis. It promotes proliferation and invasion and suppresses apoptosis, at least partly by directly binding (sponging) miR-760 and activating PI3K/AKT and MEK/ERK signaling; these effects were supported by in vitro assays and an H23 cell line-derived xenograft model."	0.7373
34858831	Frontiers in oncology	2021	Microarray Identifies a Key Carcinogenic Circular RNA 0008594 That Is Related to Non-Small-Cell Lung Cancer Development and Lymph Node Metastasis and Promotes NSCLC Progression by Regulating the miR-760-Mediated PI3K/AKT and MEK/ERK Pathways.	hsa_circ_0004293				non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"circ_0004293 was identified by microarray as down-regulated in NSCLC tissues (including LNM vs NLNM comparison) and showed lower expression in NSCLC cell lines than control cells. It was tested in vitro with overexpression, but its effects on proliferation/apoptosis were weaker than circ_0008594 and no mechanism axis was established."	0.4852
34858831	Frontiers in oncology	2021	Microarray Identifies a Key Carcinogenic Circular RNA 0008594 That Is Related to Non-Small-Cell Lung Cancer Development and Lymph Node Metastasis and Promotes NSCLC Progression by Regulating the miR-760-Mediated PI3K/AKT and MEK/ERK Pathways.	hsa_circ_0003832				non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"circ_0003832 was identified by microarray as down-regulated in NSCLC tissues (including LNM vs NLNM comparison) and showed lower expression in NSCLC cell lines than control cells. It was tested in vitro with overexpression, but its phenotypic impact was weaker than circ_0008594 and no downstream mechanism was established."	0.4852
34860442	Journal of clinical laboratory analysis	2022	Evaluation of plasma circ_0006282 as a novel diagnostic biomarker in colorectal cancer.	hsa_circ_0006282		hsa_circ_TCEB1	TCEB1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"This study identifies hsa_circ_0006282 as an up-regulated circRNA in CRC tissues, CRC plasma, and CRC cell lines. Plasma hsa_circ_0006282 shows diagnostic value by ROC analysis and dynamically decreases after surgery and increases upon recurrence, supporting its use as a non-invasive biomarker for CRC monitoring."	0.5963
34862757	"Cancer reports (Hoboken, N.J.)"	2022	Distinct noncoding RNAs and RNA binding proteins associated with high-risk pediatric and adult acute myeloid leukemias detected by regulatory network analysis.		NRIP1 	hsa_circ_NRIP1	NRIP1	acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RNA-seq	"In high-risk adult AML (TCGA), NRIP1/circNRIP1 is identified as an upregulated circRNA target associated with RBPMS in an RBP-centered regulatory network and is prognostically associated with overall survival."	0.348
34862757	"Cancer reports (Hoboken, N.J.)"	2022	Distinct noncoding RNAs and RNA binding proteins associated with high-risk pediatric and adult acute myeloid leukemias detected by regulatory network analysis.		PTK2 	hsa_circ_PTK2	PTK2	acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RNA-seq	"In high-risk adult AML (TCGA), PTK2/circPTK2 is identified as an upregulated circRNA target associated with MLLT3 in an RBP-centered regulatory network and is prognostically associated with overall survival."	0.348
34863211	Molecular cancer	2021	A novel protein AXIN1-295aa encoded by circAXIN1 activates the Wnt/beta-catenin signaling pathway to promote gastric cancer progression.		circAXIN1	hsa_circ_AXIN1	AXIN1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"circAXIN1 is up-regulated in gastric cancer and promotes malignant phenotypes (proliferation, migration, invasion, tumor growth and lung metastasis). It functions mainly by encoding AXIN1-295aa, which competes for APC binding in the Wnt destruction complex, promoting beta-catenin nuclear translocation and activation of Wnt/beta-catenin target genes."	0.8933
34863268	Diabetology & metabolic syndrome	2021	Circ-FBXW12 aggravates the development of diabetic nephropathy by binding to miR-31-5p to induce LIN28B.	hsa_circ_0123996	circ-FBXW12 	hsa_circ_FBXW12	FBXW12	diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"circ-FBXW12 is up-regulated in DN patient serum and in high-glucose_treated human mesangial cells. It promotes mesangial-cell injury phenotypes (proliferation/cell-cycle progression, inflammation, ECM accumulation and oxidative stress) by sponging miR-31-5p to increase LIN28B expression."	0.7795
34864630	Redox biology	2021	LRPPRC regulates redox homeostasis via the circANKHD1/FOXM1 axis to enhance bladder urothelial carcinoma tumorigenesis.	hsa_circ_0001541	circANKHD1 	hsa_circ_ANKHD1	ANKHD1	urothelial carcinoma of the bladder 	MONDO:0005611	bladder transitional cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"In bladder urothelial carcinoma, circANKHD1 (hsa_circ_0001541) is up-regulated and mainly localized in the cytoplasm. It promotes tumor cell proliferation and survival by sponging miR-671-5p and miR-507, thereby relieving repression of FOXM1 and enhancing downstream antioxidant programs to maintain redox homeostasis."	0.7516
34866540	Bioengineered	2021	"Exosomal circular RNA hsa_circ_007293 promotes proliferation, migration, invasion, and epithelial-mesenchymal transition of papillary thyroid carcinoma cells through regulation of the microRNA-653-5p/paired box 6 axis."	hsa_circ_007293	circ007293 			papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"In papillary thyroid carcinoma, hsa_circ_007293 (circ007293) is upregulated and enriched in serum- and cell-derived exosomes. It promotes proliferation, migration, invasion, and EMT of PTC cells by acting as a ceRNA sponge for miR-653-5p, thereby upregulating PAX6; higher serum exosomal levels correlate with advanced stage and lymph node metastasis."	0.6815
34867700	Frontiers in neurology	2021	CircNUP98 Suppresses the Maturation of miR-519a-3p in Glioblastoma.		circNUP98	hsa_circ_NUP98	NUP98	glioblastoma 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR	"circNUP98 is up-regulated in glioblastoma/GBM. It binds pre-mature miR-519a-3p and suppresses its maturation, leading to reduced mature miR-519a-3p, increased STAT3 mRNA, enhanced GBM cell proliferation, and increased tumor growth in an intracranial U87 xenograft model."	0.7718
34868028	Frontiers in immunology	2021	CircRNA75 and CircRNA72 Function as the Sponge of MicroRNA-200 to Suppress Coelomocyte Apoptosis Via Targeting Tollip in Apostichopus japonicus.		circRNA75			Apostichopus japonicus skin ulceration syndrome 	MONDO:0005583	non-human animal disease	up-regulated	RT-qPCR; RNA-seq	"In A. japonicus skin ulceration syndrome-related immune stress, circRNA75 is up-regulated and functions as a ceRNA that sponges miR-200, thereby relieving miR-200-mediated repression of Tollip and suppressing coelomocyte apoptosis."	0.7769
34868028	Frontiers in immunology	2021	CircRNA75 and CircRNA72 Function as the Sponge of MicroRNA-200 to Suppress Coelomocyte Apoptosis Via Targeting Tollip in Apostichopus japonicus.		circRNA72 	Apostichopus japonicus_circ_HSP97	HSP97	Apostichopus japonicus skin ulceration+M185 syndrome 	MONDO:0005583	non-human animal disease	up-regulated	RT-qPCR; RNA-seq	"In A. japonicus skin ulceration syndrome-related immune stress, circRNA72 is up-regulated and acts as a ceRNA that sponges miR-200, which increases Tollip expression and suppresses coelomocyte apoptosis (with weaker sponge ability than circRNA75)."	0.7769
34868302	Neural plasticity	2021	Deep Sequencing of the Rat MCAO Cortexes Reveals Crucial circRNAs Involved in Early Stroke Events and Their Regulatory Networks.		circ_Camta1_9 	rno_circ_Camta1	Camta1	Ischemic stroke 	MONDO:1060198	ischemic stroke	up-regulated	RNA-seq	"circ_Camta1_9 is upregulated in the rat MCAO cortex and is proposed to act as a ceRNA, sponging multiple miRNAs. It is implicated in poststroke hypoxic/oxidative-stress responses (e.g., promoting HIF-1a via miR-18a-3p) and in modulating inflammatory genes such as TLR-4, PD-L1, AQP-4, and Nurr1; it is also predicted to impact PTEN-related PI3K/AKT signaling."	0.1768
34868302	Neural plasticity	2021	Deep Sequencing of the Rat MCAO Cortexes Reveals Crucial circRNAs Involved in Early Stroke Events and Their Regulatory Networks.		circ_Dlgap3_1	rno_circ_Dlgap3	Dlgap3	Ischemic stroke 	MONDO:1060198	ischemic stroke	down-regulated	RNA-seq	"circ_Dlgap3_1 is reported as significantly downregulated after stroke in the rat MCAO cortex. It is proposed (via network prediction) to sponge miR-182 and thereby influence HIF-1a-related hypoxia responses, and is also linked to apoptosis regulation through targets including Bcl-2 and apoptotic protease activating factor 1."	0.1768
34868302	Neural plasticity	2021	Deep Sequencing of the Rat MCAO Cortexes Reveals Crucial circRNAs Involved in Early Stroke Events and Their Regulatory Networks.		circ_Smad4_4	rno_circ_Smad4	Smad4	Ischemic stroke 	MONDO:1060198	ischemic stroke	down-regulated	RNA-seq	circ_Smad4_4 is described as significantly downregulated in the poststroke rat cortex. The study predicts it may sponge miR-182 and thereby influence HIF-1a activation and hypoxia/oxidative-stress responses in the MCAO model.	0.1768
34868959	Frontiers in oncology	2021	The circRAB3IP Mediated by eIF4A3 and LEF1 Contributes to Enzalutamide Resistance in Prostate Cancer by Targeting miR-133a-3p/miR-133b/SGK1 Pathway.	hsa_circ_0000419	circRAB3IP	hsa_circ_RAB3IP	RAB3IP	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; RNA-seq; Microarray	"circRAB3IP (hsa_circ_0000419), derived from RAB3IP, is upregulated in enzalutamide-resistant prostate cancer cells and tissues and promotes enzalutamide resistance. It mainly localizes to the cytoplasm and acts as a ceRNA by sponging miR-133a-3p/miR-133b to increase SGK1 expression; its expression/biogenesis is promoted by eIF4A3 and LEF1."	0.8575
34869035	Frontiers in oncology	2021	"The Circ_0001367/miR-545-3p/LUZP1 Axis Regulates Cell Proliferation, Migration and Invasion in Glioma Cells."	hsa_circ_0001367				glioma	MONDO:0021042	glioma	down-regulated	RT-qPCR	"circ_0001367 is down-regulated in glioma tissues/cell lines and acts as a tumor suppressor. It inhibits glioma cell proliferation, migration and invasion by sponging miR-545-3p to upregulate LUZP1, and suppresses tumor growth in a xenograft model."	0.8487
34869393	Frontiers in cell and developmental biology	2021	CircCRIM1 Promotes Hepatocellular Carcinoma Proliferation and Angiogenesis by Sponging miR-378a-3p and Regulating SKP2 Expression.	hsa_circ_0002346	CircCRIM1 	hsa_circ_CRIM1	CRIM1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"CircCRIM1 (hsa_circ_0002346), derived from CRIM1, is upregulated in HCC tissues and cell lines and is mainly localized in the cytoplasm. It promotes HCC proliferation, G1/S cell-cycle progression and angiogenesis, and enhances xenograft growth by sponging miR-378a-3p to increase SKP2 expression (circCRIM1/miR-378a-3p/SKP2 axis). High circCRIM1 expression correlates with adverse clinicopathologic features and poorer overall survival."	0.8871
34872444	Bioengineered	2021	Hsa_circ_0001879 promotes the progression of atherosclerosis by regulating the proliferation and migration of oxidation of low density lipoprotein (ox-LDL)-induced vascular endothelial cells via the miR-6873-5p-HDAC9 axis.	hsa_circ_0001879				atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"hsa_circ_0001879 is upregulated in atherosclerosis patient tissues and in ox-LDL-treated HUVECs. It functions as a ceRNA by sponging miR-6873-5p to prevent miR-6873-5p-induced HDAC9 degradation, thereby modulating endothelial-cell proliferation, migration and EMT-related markers in the AS context."	0.6996
34872582	Cancer cell international	2021	CircTUBGCP3 facilitates the tumorigenesis of lung adenocarcinoma by sponging miR-885-3p.	hsa_circ_0007031	circTUBGCP3 	hsa_circ_TUBGCP3	TUBGCP3	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circTUBGCP3 is up-regulated in lung adenocarcinoma and functions as an oncogenic circRNA. It sponges miR-885-3p to derepress Wnt10b and activate Wnt10b/beta-catenin signaling, promoting proliferation and invasion and supporting tumor growth in xenografts. High circTUBGCP3 expression is associated with advanced pathological stage and poorer overall survival."	0.8742
34873163	Cell death discovery	2021	Circular RNA circRPPH1 promotes breast cancer progression via circRPPH1-miR-512-5p-STAT1 axis.		circRPPH1 	hsa_circ_RPPH1	RPPH1	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	circRPPH1 is up-regulated in breast cancer tissues and cell lines and functions as an oncogenic circRNA. It localizes mainly in the cytoplasm and promotes proliferation and migration by sponging miR-512-5p to increase STAT1 expression (circRPPH1/miR-512-5p/STAT1 axis).	0.8539
34873976	Bioengineered	2021	Circular RNA expression alteration and bioinformatics analysis in patients with acute cerebral infarction injury.		hsa_circRNA_000581	hsa_circ_WDR20	WDR20	acute cerebral infarction 	MONDO:0002679	cerebral infarction	down-regulated	RT-qPCR; RNA-seq	"hsa_circRNA_000581 (host gene WDR20) is significantly down-regulated in plasma from acute cerebral infarction patients versus controls and was validated by RT-qPCR. The study computationally predicted its candidate miRNA binding partners, suggesting a potential circRNA/miRNA regulatory role, but no functional experiments were performed."	0.4032
34873976	Bioengineered	2021	Circular RNA expression alteration and bioinformatics analysis in patients with acute cerebral infarction injury.		hsa_circRNA_092476	hsa_circ_AC004076.9		acute cerebral infarction 	MONDO:0002679	cerebral infarction	down-regulated	RT-qPCR; RNA-seq	"hsa_circRNA_092476 (host gene AC004076.9) is significantly down-regulated in plasma from acute cerebral infarction patients and was validated by RT-qPCR. The study predicted candidate miRNA response elements for this circRNA computationally, but did not experimentally verify downstream targets or functions."	0.4032
34873976	Bioengineered	2021	Circular RNA expression alteration and bioinformatics analysis in patients with acute cerebral infarction injury.		hsa_circRNA_101836	hsa_circ_NFATC3	NFATC3	acute cerebral infarction 	MONDO:0002679	cerebral infarction	down-regulated	RT-qPCR; RNA-seq	"hsa_circRNA_101836 (host gene NFATC3) is significantly down-regulated in plasma from acute cerebral infarction patients versus controls and was validated by RT-qPCR. Bioinformatic predictions suggest it may bind several miRNAs, but the paper provides no experimental evidence for downstream targets or cellular functions."	0.4032
34873976	Bioengineered	2021	Circular RNA expression alteration and bioinformatics analysis in patients with acute cerebral infarction injury.		hsa_circRNA_102183	hsa_circ_BPTF	BPTF	acute cerebral infarction 	MONDO:0002679	cerebral infarction	down-regulated	RT-qPCR; RNA-seq	"hsa_circRNA_102183 (host gene BPTF) is significantly down-regulated in plasma from acute cerebral infarction patients and was validated by RT-qPCR. Its miRNA response elements were predicted bioinformatically, but the study did not experimentally validate downstream targets, pathways, or functional effects."	0.4032
34873976	Bioengineered	2021	Circular RNA expression alteration and bioinformatics analysis in patients with acute cerebral infarction injury.		hsa_circRNA_103372	hsa_circ_IP6K2	IP6K2	acute cerebral infarction 	MONDO:0002679	cerebral infarction	up-regulated	RT-qPCR; RNA-seq	"hsa_circRNA_103372 (host gene IP6K2) is significantly up-regulated in plasma from acute cerebral infarction patients versus controls and was validated by RT-qPCR. The paper predicts candidate miRNA binding sites for this circRNA computationally, but does not experimentally validate downstream targets or biological functions."	0.4032
34876132	Molecular cancer	2021	CircDOCK1 promotes the tumorigenesis and cisplatin resistance of osteogenic sarcoma via the miR-339-3p/IGF1R axis.	hsa_circ_0020378	circDOCK1	hsa_circ_DOCK1	DOCK1	osteogenic sarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"circDOCK1 is up-regulated in osteogenic sarcoma tissues/cells and mainly localized in the cytoplasm. It promotes malignant phenotypes (proliferation, migration, invasion, tumor growth/metastasis) and reduces apoptosis, and it contributes to cisplatin resistance by sponging miR-339-3p to upregulate IGF1R."	0.8999
34876161	Journal of neuroinflammation	2021	Down-regulation of circular RNA CDC14A peripherally ameliorates brain injury in acute phase of ischemic stroke.		circCDC14A 	mmu_circ_CDC14A	CDC14A	ischemic stroke 	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR	"circCDC14A is up-regulated in plasma and peri-infarct cortex after tMCAO and localizes mainly to peripheral neutrophils and peri-infarct astrocytes. Peripheral knockdown of circCDC14A reduces infarct volume and astrocyte activation, improves neurological scores and survival, and increases the proportion of N2 (Ly6G+/YM1+) neutrophils, suggesting a role in neuroinflammatory injury during acute ischemic stroke."	0.6516
34876825	"Diabetes, metabolic syndrome and obesity : targets and therapy"	2021	"Overexpression of circACTR2 in Gestational Diabetes Mellitus Predicts Intrauterine Death, Fetal Malformation, and Intrauterine Infection."		circACTR2 	hsa_circ_ACTR2	ACTR2	gestational diabetes mellitus 	MONDO:0005406	gestational diabetes	up-regulated	RT-qPCR	"circACTR2 is up-regulated in the plasma of women who develop GDM. Elevated plasma circACTR2 at ~1 month of gestation predicts subsequent GDM, and higher levels among GDM patients associate with increased risk of several adverse pregnancy outcomes."	0.4187
34880642	Journal of inflammation research	2021	Circular RNA Foxo3 Relieves Myocardial Ischemia/Reperfusion Injury by Suppressing Autophagy via Inhibiting HMGB1 by Repressing KAT7 in Myocardial Infarction.		circFoxo3	rno_circ_Foxo3	FoxO3	myocardial infarction 	MONDO:0005068	myocardial infarction	down-regulated	RT-qPCR	"circFoxo3 is downregulated in MI/I/R models. circFoxo3 overexpression protects myocardium/cardiomyocytes by suppressing autophagy, apoptosis and inflammation, acting through a KAT7¡úHMGB1 transcriptional regulation module (reduced KAT7-associated H3K14ac and RNA pol II enrichment on the HMGB1 promoter)."	0.6741
34887661	International journal of nanomedicine	2021	Therapeutic Potential of Exosomal circRNA Derived from Synovial Mesenchymal Cells via Targeting circEDIL3/miR-485-3p/PIAS3/STAT3/VEGF Functional Module in Rheumatoid Arthritis.	hsa_circ_0073244	circEDIL3	hsa_circ_EDIL3	EDIL3	rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	unknown	RT-qPCR	"Exosomal circEDIL3 from synovial MSCs suppresses IL-6_driven angiogenesis in RA by sponging miR-485-3p, thereby increasing PIAS3 and inhibiting STAT3 activity to reduce VEGF. Delivery of circEDIL3-enriched exosomes alleviates arthritis severity in the CIA mouse model."	0.7799
34887753	Frontiers in pharmacology	2021	Circular RNA CREBBP Suppresses Hepatic Fibrosis Via Targeting the hsa-miR-1291/LEFTY2 Axis.	hsa_circ_0007637	circCREBBP 	hsa_circ_CREBBP	CREBBP	hepatic fibrosis 	MONDO:0100430	fibrotic liver disease	down-regulated	RT-qPCR; RNA-seq	"circCREBBP is down-regulated in hepatic fibrosis and exerts anti-fibrotic effects by inhibiting hepatic stellate cell activation and proliferation. Mechanistically, it functions as a ceRNA by sponging hsa-miR-1291 to increase LEFTY2 expression, thereby alleviating fibrosis in vitro and in a CCl4-induced mouse model."	0.8067
34887753	Frontiers in pharmacology	2021	Circular RNA CREBBP Suppresses Hepatic Fibrosis Via Targeting the hsa-miR-1291/LEFTY2 Axis.	mmu_circ_0006288	circCREBBP 	mmu_circ_CREBBP	CREBBP	hepatic fibrosis 	MONDO:0100430	fibrotic liver disease	down-regulated	RT-qPCR; RNA-seq	"circCREBBP is down-regulated in hepatic fibrosis and exerts anti-fibrotic effects by inhibiting hepatic stellate cell activation and proliferation. Mechanistically, it functions as a ceRNA by sponging hsa-miR-1291 to increase LEFTY2 expression, thereby alleviating fibrosis in vitro and in a CCl4-induced mouse model."	0.8067
34887922	Journal of oncology	2021	circ_0075943 Dominates the miR-141-3p/AK2 Network to Support the Development of Breast Carcinoma.	hsa_circ_0075943	circ_0075943			Breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0075943 is up-regulated in breast cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes breast cancer cell proliferation, migration and invasion while inhibiting apoptosis, and it supports tumor growth in vivo by sponging miR-141-3p to derepress AK2 (circ_0075943/miR-141-3p/AK2 axis)."	0.7554
34888309	Frontiers in cell and developmental biology	2021	Methyltransferase-Like 3-Mediated m6A Methylation of Hsa_circ_0058493 Accelerates Hepatocellular Carcinoma Progression by Binding to YTH Domain-Containing Protein 1.	hsa_circ_0058493		hsa_circ_RHBDD1	RHBDD1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0058493 is up-regulated in HCC tissues and cells and acts as an oncogenic circRNA that promotes proliferation, cell-cycle progression, migration/invasion and tumor growth while inhibiting apoptosis. METTL3-mediated m6A modification enables YTHDC1 binding, which facilitates nuclear export of hsa_circ_0058493 to the cytoplasm and contributes to HCC progression; high expression predicts worse survival."	0.8814
34889689	Bioengineered	2021	Circular RNA_0000326 promotes bladder cancer progression via microRNA-338-3p/ETS Proto-Oncogene 1/phosphoinositide-3 kinase/Akt pathway.	hsa_circ_0000326	circ_0000326 			bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0000326 is up-regulated in bladder cancer tissues and cell lines and promotes malignant phenotypes (proliferation and migration) while inhibiting apoptosis. Mechanistically, it mainly localizes to the cytoplasm and functions as a ceRNA that sponges miR-338-3p to up-regulate ETS1, thereby activating the PI3K/AKT pathway."	0.7884
34890089	Cancer science	2022	hsa_circ_0003410 promotes hepatocellular carcinoma progression by increasing the ratio of M2/M1 macrophages through the miR-139-3p/CCL5 axis.	hsa_circ_0003410		hsa_circ_UBAP2	UBAP2	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0003410 is up-regulated in HCC and promotes proliferation, migration, and in vivo tumor growth. It functions as a ceRNA by sponging miR-139-3p to upregulate CCL5, which enhances M2 macrophage recruitment/polarization and increases the M2/M1 macrophage ratio in the HCC microenvironment."	0.8428
34893581	Translational psychiatry	2021	Circular RNA circCCNT2 is upregulated in the anterior cingulate cortex of individuals with bipolar disorder.	hsa_circ_0056537	circCCNT2	hsa_circ_CCNT2	CCNT2	bipolar disorder 	MONDO:0004985	bipolar disorder	up-regulated	RT-qPCR; RNA-seq	"circCCNT2 (hsa_circ_0056537), derived from CCNT2, is upregulated in bipolar disorder in post-mortem anterior cingulate cortex and also elevated in BD-derived B-lymphoblastoid cells. Lithium treatment reduces circCCNT2 expression in vitro, and bioinformatic predictions suggest potential interactions with miR-877-5p and multiple RBPs, though functional mechanisms were not experimentally established."	0.6193
34894939	Annals of medicine	2021	"Analysis of a circRNA-, miRNA-, and mRNA-associated ceRNA network reveals potential biomarkers in preeclampsia a ceRNA network in preeclampsia."	hsa_circ_0087208				Preeclampsia 	MONDO:0005081	preeclampsia	unknown	Microarray	"In placental tissues from preeclampsia datasets, hsa_circ_0087208 was predicted in a ceRNA network to bind miR-1248 and thereby upregulate GNB5, potentially affecting the PI3K-Akt signaling pathway in PE."	0.1768
34894939	Annals of medicine	2021	"Analysis of a circRNA-, miRNA-, and mRNA-associated ceRNA network reveals potential biomarkers in preeclampsia a ceRNA network in preeclampsia."	hsa_circ_0035443				Preeclampsia 	MONDO:0005081	preeclampsia	unknown	Microarray	"hsa_circ_0035443 was predicted in PE placental tissue data to act as a ceRNA by binding miR-1248 and increasing GNB5, potentially influencing PI3K-Akt signaling."	0.1768
34894939	Annals of medicine	2021	"Analysis of a circRNA-, miRNA-, and mRNA-associated ceRNA network reveals potential biomarkers in preeclampsia a ceRNA network in preeclampsia."	hsa_circ_0067557				Preeclampsia 	MONDO:0005081	preeclampsia	unknown	Microarray	hsa_circ_0067557 was predicted in PE placental tissue microarray data to bind miR-1248 and upregulate GNB5 as part of a ceRNA network linked to PI3K-Akt signaling.	0.1768
34894939	Annals of medicine	2021	"Analysis of a circRNA-, miRNA-, and mRNA-associated ceRNA network reveals potential biomarkers in preeclampsia a ceRNA network in preeclampsia."	hsa_circ_0052661				Preeclampsia 	MONDO:0005081	preeclampsia	unknown	Microarray	"hsa_circ_0052661 was predicted to act as a ceRNA in PE placental tissues, binding miR-4303 to increase IL2RB, implicating PI3K-Akt signaling via the network context."	0.1768
34897031	Aging	2021	"hsa_circ_0072389, hsa_circ_0072386, hsa_circ_0008621, hsa_circ_0072387, and hsa_circ_0072391 aggravate glioma via miR-338-5p/IKBIP."	hsa_circ_0072389		hsa_circ_HMGCS1	HMGCS1	glioma	MONDO:0021042	glioma	dysregulated	RT-qPCR; Microarray	"This study proposes that hsa_circ_0072389 (from host gene HMGCS1) aggravates glioma by sponging miR-338-5p, thereby relieving repression of IKBIP and promoting downstream NF-kappaB/JAK/STAT/TGFbeta-SMAD signaling."	0.4474
34897031	Aging	2021	"hsa_circ_0072389, hsa_circ_0072386, hsa_circ_0008621, hsa_circ_0072387, and hsa_circ_0072391 aggravate glioma via miR-338-5p/IKBIP."	hsa_circ_0072386		hsa_circ_HMGCS1	HMGCS1	glioma	MONDO:0021042	glioma	dysregulated	RT-qPCR; Microarray	"hsa_circ_0072386 (HMGCS1-derived) is proposed to aggravate glioma by binding miR-338-5p and relieving repression of IKBIP, contributing to activation of NF-kappaB/JAK/STAT/TGFbeta-SMAD signaling."	0.4474
34897031	Aging	2021	"hsa_circ_0072389, hsa_circ_0072386, hsa_circ_0008621, hsa_circ_0072387, and hsa_circ_0072391 aggravate glioma via miR-338-5p/IKBIP."	hsa_circ_0008621		hsa_circ_HMGCS1	HMGCS1	glioma	MONDO:0021042	glioma	dysregulated	RT-qPCR; Microarray	"hsa_circ_0008621 (HMGCS1-derived) is proposed to aggravate glioma through a ceRNA mechanism by binding miR-338-5p and promoting IKBIP, with inferred activation of NF-kappaB/JAK/STAT/TGFbeta-SMAD signaling."	0.4474
34897031	Aging	2021	"hsa_circ_0072389, hsa_circ_0072386, hsa_circ_0008621, hsa_circ_0072387, and hsa_circ_0072391 aggravate glioma via miR-338-5p/IKBIP."	hsa_circ_0072387		hsa_circ_HMGCS1	HMGCS1	glioma	MONDO:0021042	glioma	dysregulated	RT-qPCR; Microarray	"hsa_circ_0072387 (HMGCS1-derived) is proposed to sponge miR-338-5p, increase IKBIP, and thereby aggravate glioma with inferred activation of NF-kappaB/JAK/STAT/TGFbeta-SMAD signaling."	0.4474
34897031	Aging	2021	"hsa_circ_0072389, hsa_circ_0072386, hsa_circ_0008621, hsa_circ_0072387, and hsa_circ_0072391 aggravate glioma via miR-338-5p/IKBIP."	hsa_circ_0072391		hsa_circ_HMGCS1	HMGCS1	glioma	MONDO:0021042	glioma	dysregulated	RT-qPCR; Microarray	"hsa_circ_0072391 (HMGCS1-derived) is proposed to sponge miR-338-5p, increase IKBIP, and thereby aggravate glioma with inferred activation of NF-kappaB/JAK/STAT/TGFbeta-SMAD signaling."	0.4474
34898351	Bioengineered	2021	"Circular RNA circ_0000423 promotes gastric cancer cell proliferation, migration and invasion via the microR-582-3p/Disheveled-Axin domain containing 1 axis."	hsa_circ_0000423	circ_0000423	hsa_circ_PPP1R12A	PPP1R12A	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circ_0000423 is up-regulated in gastric cancer tissues and cell lines and promotes GC cell viability/proliferation, migration, and invasion. Mechanistically, it sponges miR-582-3p to de-repress DIXDC1, forming a circ_0000423/miR-582-3p/DIXDC1 ceRNA axis that drives malignant phenotypes."	0.814
34898366	Bioengineered	2022	Circular RNA expression profiles following negative pressure wound therapy in burn wounds with experimental Pseudomonas aeruginosa infection.	mmu_circ_0004796	"chr13_76759820_76741294_+18,526-Mctp1"	mmu_circ_Mctp1	Mctp1	P. aeruginosa-infected burn wounds 	MONDO:0040732	Pseudomonas aeruginosa infectious disease	up-regulated	RT-qPCR; RNA-seq	mmu_circ_0004796 (Mctp1) is up-regulated in NPWT-treated P. aeruginosa-infected burn wound tissues and is proposed to function as a miRNA sponge within circRNA_miRNA_mRNA regulatory networks linked to immune/inflammatory responses.	0.3684
34898366	Bioengineered	2022	Circular RNA expression profiles following negative pressure wound therapy in burn wounds with experimental Pseudomonas aeruginosa infection.	mmu_circ_0011322	chr4_137557440_137557174_+266-Hspg2	mmu_circ_Hspg2	Hspg2	P. aeruginosa-infected burn wounds 	MONDO:0040732	Pseudomonas aeruginosa infectious disease	up-regulated	RT-qPCR; RNA-seq	mmu_circ_0011322 (Hspg2) is up-regulated in NPWT-treated P. aeruginosa-infected burn wound tissues and is part of predicted circRNA_miRNA_mRNA (ceRNA) sponge networks associated with immune/inflammatory pathways.	0.2465
34898366	Bioengineered	2022	Circular RNA expression profiles following negative pressure wound therapy in burn wounds with experimental Pseudomonas aeruginosa infection.	mmu_circ_0001240	chr4_108719812_108717789_-2023-Zfyve9	mmu_circ_Zfyve9	Zfyve9	P. aeruginosa-infected burn wounds 	MONDO:0040732	Pseudomonas aeruginosa infectious disease	down-regulated	RT-qPCR; RNA-seq	mmu_circ_0001240 (Zfyve9) is down-regulated after NPWT in P. aeruginosa-infected burn wound tissues and is included in predicted ceRNA sponge networks potentially related to immune/inflammatory signaling.	0.2465
34898366	Bioengineered	2022	Circular RNA expression profiles following negative pressure wound therapy in burn wounds with experimental Pseudomonas aeruginosa infection.	mmu_circ_0013121	chr6_134761434_134758619_-2815-Dusp16	mmu_circ_Dusp16	Dusp16	P. aeruginosa-infected burn wounds 	MONDO:0040732	Pseudomonas aeruginosa infectious disease	down-regulated	RT-qPCR; RNA-seq	mmu_circ_0013121 (Dusp16) is down-regulated after NPWT in infected burn wound tissues and is included among five key differentially expressed circRNAs predicted to act as miRNA sponges in circRNA_miRNA_mRNA networks.	0.2465
34898366	Bioengineered	2022	Circular RNA expression profiles following negative pressure wound therapy in burn wounds with experimental Pseudomonas aeruginosa infection.		chr17_80053641_80044494_-9147-Hnrnpll (circRNA Hnrnpll) 	mmu_circ_Hnrnpll	Hnrnpll	P. aeruginosa-infected burn wounds 	MONDO:0040732	Pseudomonas aeruginosa infectious disease	down-regulated	RT-qPCR; RNA-seq	circRNA Hnrnpll is down-regulated after NPWT in infected burn wound tissues and is one of five key differentially expressed circRNAs predicted to act as miRNA sponges in circRNA_miRNA_mRNA networks.	0.2465
34898474	Aging	2021	"YY1 and eIF4A3 are mediators of the cell proliferation, migration and invasion in cholangiocarcinoma promoted by circ-ZNF609 by targeting miR-432-5p to regulate LRRC1."	hsa_circ_0000615	circ-ZNF609 	hsa_circ_ZNF609	ZNF609	cholangiocarcinoma 	MONDO:0019087	cholangiocarcinoma	up-regulated	RT-qPCR	"circ-ZNF609 is up-regulated in cholangiocarcinoma and functions as an oncogenic circRNA that promotes proliferation, migration, invasion and xenograft growth. Mechanistically, it sponges miR-432-5p to up-regulate LRRC1, while YY1 enhances its transcription and eIF4A3 promotes its circularization by binding the pre-mRNA."	0.849
34899853	Frontiers in genetics	2021	CircARVCF Contributes to Cisplatin Resistance in Gastric Cancer by Altering miR-1205 and FGFR1.	hsa_circ_0092330	circARVCF	hsa_circ_ARVCF	ARVCF	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circARVCF is upregulated in cisplatin-resistant gastric cancer tissues/cells and promotes DDP resistance and malignant phenotypes. Mechanistically, it acts as a ceRNA by sponging miR-1205 to increase FGFR1 expression, and circARVCF knockdown improves DDP sensitivity in vitro and in a xenograft model."	0.8171
34899908	Journal of oncology	2021	CircRNF13 Promotes the Malignant Progression of Pancreatic Cancer through Targeting miR-139-5p/IGF1R Axis.		circRNF13 	hsa_circ_RNF13	RNF13	pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"circRNF13 is up-regulated in pancreatic cancer tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion). Mechanistically, circRNF13 mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-139-5p to increase IGF1R expression, thereby driving pancreatic cancer progression."	0.7859
34900398	Molecular therapy. Nucleic acids	2021	Whole-transcriptome analysis of aluminum-exposed rat hippocampus and identification of ceRNA networks to investigate neurotoxicity of Al.	rno_circ_0001722				aluminum-induced neurotoxicity 	MONDO:0005527	toxic encephalopathy	down-regulated	RT-qPCR; RNA-seq	"rno_circ_0001722 is down-regulated in aluminum-exposed rat hippocampus and is highlighted as a central node in the circRNA-associated ceRNA network, including the PI3K/AKT pathway network. It is predicted to sponge multiple miRNAs (e.g., rno-miR-143-5p) to regulate IRS1 expression, potentially contributing to aluminum-induced neurotoxicity/AD-like pathology."	0.3684
34900398	Molecular therapy. Nucleic acids	2021	Whole-transcriptome analysis of aluminum-exposed rat hippocampus and identification of ceRNA networks to investigate neurotoxicity of Al.	rno_circ_0005551				aluminum-induced neurotoxicity 	MONDO:0005527	toxic encephalopathy	down-regulated	RT-qPCR	"rno_circ_0005551 is down-regulated in aluminum-exposed rat hippocampus and appears in the circRNA-associated ceRNA network with the up-regulated miRNA rno-miR-665. The study provides expression evidence and primer information for RT-qPCR validation, but does not report a specific downstream target axis for this circRNA."	0.2586
34900665	Frontiers in oncology	2021	Circular RNA Circ_0000098 Elevates ALX4 Expression via Adsorbing miR-1204 to Inhibit the Progression of Hepatocellular Carcinoma.	hsa_circ_0000098		hsa_circ_SLC30A7	SLC30A7	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"circ_0000098 (circSLC30A7) is down-regulated in HCC tissues/cells and acts as a tumor-suppressive circRNA. It functions mainly in the cytoplasm as a ceRNA that sponges miR-1204, thereby relieving repression of ALX4 and inhibiting proliferation, migration, invasion, EMT, and lung metastasis."	0.8206
34900700	Frontiers in oncology	2021	Plasma-Derived Extracellular Vesicles Circular RNAs Serve as Biomarkers for Breast Cancer Diagnosis.	hsa_circ_0002190				breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0002190 is elevated in plasma-derived extracellular vesicles of breast cancer patients and is included in the nine-circRNA diagnostic classifier (BCExoC) for distinguishing breast cancer patients from controls.	0.5047
34900700	Frontiers in oncology	2021	Plasma-Derived Extracellular Vesicles Circular RNAs Serve as Biomarkers for Breast Cancer Diagnosis.	hsa_circ_0007177				breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0007177 is elevated in plasma-derived extracellular vesicles of breast cancer patients and is included in the nine-circRNA diagnostic classifier (BCExoC).	0.5047
34900700	Frontiers in oncology	2021	Plasma-Derived Extracellular Vesicles Circular RNAs Serve as Biomarkers for Breast Cancer Diagnosis.	hsa_circ_0000642				breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0000642 is elevated in plasma-derived extracellular vesicles of breast cancer patients and is included in the BCExoC diagnostic classifier.	0.5047
34900700	Frontiers in oncology	2021	Plasma-Derived Extracellular Vesicles Circular RNAs Serve as Biomarkers for Breast Cancer Diagnosis.	hsa_circ_0001439				breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0001439 is elevated in plasma EVs from breast cancer patients and is part of the BCExoC diagnostic signature.	0.5047
34900700	Frontiers in oncology	2021	Plasma-Derived Extracellular Vesicles Circular RNAs Serve as Biomarkers for Breast Cancer Diagnosis.	hsa_circ_0001417				breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0001417 is elevated in plasma EVs of breast cancer patients and contributes to the multi-circRNA diagnostic classifier BCExoC.	0.5047
34900700	Frontiers in oncology	2021	Plasma-Derived Extracellular Vesicles Circular RNAs Serve as Biomarkers for Breast Cancer Diagnosis.	hsa_circ_0005552				breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0005552 is elevated in plasma EVs from breast cancer patients and is part of the BCExoC diagnostic panel.	0.5047
34900700	Frontiers in oncology	2021	Plasma-Derived Extracellular Vesicles Circular RNAs Serve as Biomarkers for Breast Cancer Diagnosis.	hsa_circ_0001073				breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0001073 is elevated in plasma-derived EVs in breast cancer and is included in the BCExoC diagnostic classifier.	0.5047
34900700	Frontiers in oncology	2021	Plasma-Derived Extracellular Vesicles Circular RNAs Serve as Biomarkers for Breast Cancer Diagnosis.	hsa_circ_0000267				breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0000267 is up-regulated in plasma EVs in breast cancer and is included in the BCExoC diagnostic signature.	0.5047
34900700	Frontiers in oncology	2021	Plasma-Derived Extracellular Vesicles Circular RNAs Serve as Biomarkers for Breast Cancer Diagnosis.	hsa_circ_0006404				breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0006404 is elevated in plasma EVs from breast cancer patients and is included in the BCExoC diagnostic classifier.	0.5047
34901263	International journal of genomics	2021	circHUWE1 Exerts an Oncogenic Role in Inducing DDP-Resistant NSCLC Progression Depending on the Regulation of miR-34a-5p/TNFAIP8.	hsa_circ_0004396	circHUWE1	hsa_circ_HUWE1	HUWE1	non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circHUWE1 is upregulated in NSCLC, particularly in cisplatin (DDP)-resistant tissues/cells. It promotes DDP resistance and malignant behaviors by sponging miR-34a-5p and derepressing TNFAIP8, and its knockdown suppresses xenograft growth."	0.8571
34901284	BioMed research international	2021	hsa_circ_0023305 Enhances Laryngeal Squamous Cell Carcinoma Progression and Modulates TRPM7 via miR-218-5p Sponging.	hsa_circ_0023305		hsa_circ_CCND1	CCND1	laryngeal squamous cell carcinoma 	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR; ISH	"hsa_circ_0023305 is up-regulated in LSCC tissues and promotes proliferation, migration/invasion and metastasis. Mechanistically, it acts as a sponge for miR-218-5p, thereby relieving repression of TRPM7 and enhancing LSCC progression, and its high expression associates with poor overall survival."	0.7631
34901392	Molecular therapy oncolytics	2021	Circular RNA circRAB31 acts as a miR-885-5psponge to suppress gastric cancer progressionvia the PTEN/PI3K/AKT pathway.	hsa_circ_0008821	circRAB31 	hsa_circ_RAB31	RAB31	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"circRAB31 is downregulated in gastric cancer and functions as a tumor suppressor. It sponges miR-885-5p to relieve repression of PTEN, thereby inhibiting PI3K/AKT signaling and reducing proliferation, migration, invasion, tumor growth and metastasis."	0.8792
34901459	"Open medicine (Warsaw, Poland)"	2021	circATP2A2 promotes osteosarcoma progression by upregulating MYH9.	hsa_circ_0028173	circATP2A2	hsa_circ_ATP2A2	ATP2A2	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"circATP2A2 is upregulated in osteosarcoma tissues/cells and patient serum and mainly localizes to the cytoplasm. It promotes osteosarcoma malignant behaviors and glycolysis by sponging miR-335-5p to upregulate MYH9, and its high expression indicates worse overall survival and has diagnostic potential."	0.8621
34903141	Bioengineered	2021	Downregulation of Circular RNA PSEN1 ameliorates ferroptosis of the high glucose treated retinal pigment epithelial cells via miR-200b-3p/cofilin-2 axis.	hsa_circ_0008521	circ-PSEN1 	hsa_circ_PSEN1	PSEN1	diabetic retinopathy 	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR	"circ-PSEN1 is up-regulated in a high-glucose ARPE19 cell model of diabetic retinopathy and promotes ferroptosis. Mechanistically, circ-PSEN1 sponges miR-200b-3p to regulate the downstream target CFL2, and circ-PSEN1 knockdown mitigates ferroptosis-related cell death."	0.7166
34903799	Scientific reports	2021	CircFOXM1 promotes proliferation and metastasis of hepatocellular carcinoma via regulating miR-1179/SPAG5 axis.	hsa_circ_0025033	circFOXM1	hsa_circ_FOXM1	FOXM1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circFOXM1 is upregulated in HCC cells/tissues and functions as an oncogenic circRNA. It promotes proliferation and metastatic phenotypes by sponging miR-1179, thereby increasing SPAG5 expression, and enhances xenograft tumor growth."	0.7581
34905439	Bioengineered	2021	Serum hsa_circ_0087776 as a new oncologic marker for the joint diagnosis of multiple myeloma.	hsa_circ_0087776				multiple myeloma 	MONDO:0009693	plasma cell myeloma	down-regulated	RT-qPCR	"This study reports that serum hsa_circ_0087776 is significantly down-regulated in multiple myeloma and shows consistent low expression in MM cell lines. It demonstrates diagnostic utility (AUC 0.722) and improved sensitivity when combined with ALB and beta2-MG, suggesting hsa_circ_0087776 as a potential noninvasive biomarker; no specific molecular mechanism was experimentally established."	0.6608
34905503	Aging	2021	Hsa_circ_0008259 modulates miR-21-5p and PDCD4 expression to restrain osteosarcoma progression.	hsa_circ_0008259		hsa_circ_LMO7	LMO7	osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; Microarray	"circ_0008259 is down-regulated in osteosarcoma tissues and cell lines and functions as a tumor suppressor. It mainly localizes to the cytoplasm and acts as a ceRNA that sponges miR-21-5p, thereby relieving miR-21-5p-mediated repression of PDCD4 and inhibiting malignant phenotypes while promoting apoptosis."	0.8058
34906151	Cancer cell international	2021	CircSEC24A upregulates TGFBR2 expression to accelerate pancreatic cancer proliferation and migration via sponging to miR-606.	hsa_circ_0003180	circSEC24A	hsa_circ_SEC24A	SEC24A	pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; Microarray	"circSEC24A is up-regulated in pancreatic cancer tissues and cell lines and promotes pancreatic cancer cell proliferation, migration, invasion, EMT and xenograft tumor growth. Mechanistically, it acts as a ceRNA by sponging miR-606 to de-repress TGFBR2, which contributes to activation of PI3K/AKT signaling."	0.7995
34911533	Molecular cancer	2021	The circular RNA circDLG1 promotes gastric cancer progression and anti-PD-1 resistance through the regulation of CXCL12 by sponging miR-141-3p.	hsa_circ_0008583	circDLG1 	hsa_circ_DLG1	DLG1	gastric cancer	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; ISH; Microarray	"circDLG1 (hsa_circ_0008583) is upregulated in metastatic and anti-PD-1_resistant gastric cancer tissues. It promotes proliferation, invasion/metastasis and immune evasion by sponging miR-141-3p to upregulate CXCL12, driving MDSC infiltration and anti-PD-1 resistance; high circDLG1 predicts worse PFS in anti-PD-1_treated patients."	0.8941
34912799	Frontiers in cell and developmental biology	2021	Hsa_Circ_0001860 Promotes Smad7 to Enhance MPA Resistance in Endometrial Cancer via miR-520h.	hsa_circ_0001860				endometrial cancer 	MONDO:0011962	endometrial cancer	down-regulated	RT-qPCR; RNA-seq	"This study identifies hsa_circ_0001860 as down-regulated in MPA-resistant endometrial cancer cells and tissues. Functionally, its downregulation promotes malignant phenotypes and MPA resistance, while its restoration improves MPA sensitivity. Mechanistically, hsa_circ_0001860 sponges miR-520 h to increase Smad7 and modulate EMT-related signaling."	0.8107
34912844	Frontiers in molecular biosciences	2021	CircularLRRC7 is a Potential Tumor Suppressor Associated With miR-1281 and PDXP Expression in Glioblastoma.	hsa_circ_0114014	circLRRC7	hsa_circ_LRRC7	LRRC7	glioblastoma 	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR; RNA-seq	"circLRRC7 (hsa_circ_0114014), derived from LRRC7, is markedly down-regulated in glioblastoma and is associated with better patient survival when expressed at higher levels. The study proposes a circLRRC7_miR-1281_PDXP regulatory relationship supported by database prediction and expression/correlation analyses in GBM tissues."	0.7034
34912856	Frontiers in cardiovascular medicine	2021	Hsa_circ_0003204 Knockdown Weakens Ox-LDL-Induced Cell Injury by Regulating miR-188-3p/TRPC6 Axis in Human Carotid Artery Endothelial Cells and THP-1 Cells.	hsa_circ_0003204		hsa_circ_USP36	USP36	atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"In ox-LDL-treated HCtAECs and THP-1 cells (in vitro carotid atherosclerosis model), circ_0003204 is up-regulated and promotes cell injury. Mechanistically, circ_0003204 acts as a ceRNA that sponges miR-188-3p to increase TRPC6, thereby enhancing endothelial apoptosis and promoting inflammatory response and oxidative stress; circ_0003204 knockdown is protective."	0.627
34913063	Molecular medicine reports	2022	CircRNA_0044556 diminishes the sensitivity of triple_negative breast cancer cells to adriamycin by sponging miR_145 and regulating NRAS.	hsa_circ_0044556	circRNA_0044556			triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"circRNA_0044556 is upregulated in TNBC tissues/cells (especially ADM-resistant) and reduces adriamycin sensitivity. Functionally, it promotes viability, migration and drug resistance while inhibiting apoptosis by sponging miR-145 and derepressing NRAS."	0.6996
34917303	Journal of healthcare engineering	2021	Circular RNA mmu_circ_0001598 Contributes to IL-1beta-Induced Osteoarthritis Progression by Regulating miR-127-3p.	mmu_circ_0001598	circ_0001598 			Osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"mmu_circ_0001598 is up-regulated in IL-1beta-stimulated mouse chondrocytes and ACLT-induced OA cartilage. Its knockdown promotes chondrocyte proliferation, reduces apoptosis and matrix degradation, and alleviates OA in vivo, at least partly via a circ_0001598/miR-127-3p axis affecting MMP-13 and COL2A1."	0.4611
34922539	Molecular cancer	2021	circCHST15 is a novel prognostic biomarker that promotes clear cell renal cell carcinoma cell proliferation and metastasis through the miR-125a-5p/EIF4EBP1 axis.	hsa_circ_0020303	circCHST15 	hsa_circ_CHST15	CHST15	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR; Microarray	"circCHST15 (hsa_circ_0020303), derived from the host gene CHST15, is upregulated in ccRCC tissues and cell lines and mainly localizes in the cytoplasm. It promotes ccRCC proliferation, migration/invasion and in vivo tumor growth/metastasis by sponging miR-125a-5p to increase EIF4EBP1, with involvement of PI3K-AKT-mTOR signaling. High circCHST15 is associated with advanced stage and independently predicts poorer OS and PFS in the SYSU cohort."	0.8925
34922544	Molecular cancer	2021	CircIL4R activates the PI3K/AKT signaling pathway via the miR-761/TRIM29/PHLPP1 axis and promotes proliferation and metastasis in colorectal cancer.	hsa_circ_0038718	circIL4R	hsa_circ_IL4R	IL4R	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; Microarray	"circIL4R (hsa_circ_0038718), derived from IL4R, is upregulated in colorectal cancer tissues and serum and mainly localizes to the cytoplasm. It promotes CRC proliferation, migration, invasion and metastasis by acting as a ceRNA for miR-761, thereby increasing TRIM29 and inducing TRIM29-mediated ubiquitination/degradation of PHLPP1 to activate PI3K/AKT signaling. High circIL4R is associated with aggressive clinicopathological features and poor OS/DFS and has diagnostic potential in serum."	0.8989
34922560	Biomedical engineering online	2021	Microarray analysis and functional prediction of differentially expressed circular RNAs in acquired middle ear cholesteatoma.		hsa_circRNA_104327			acquired middle ear cholesteatoma 	MONDO:0006533	cholesteatoma of middle ear	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_104327 is significantly up-regulated in acquired middle ear cholesteatoma versus normal skin and was included in a predicted circRNA_miRNA_mRNA ceRNA network, interacting with miRNA-152-5p."	0.4032
34922560	Biomedical engineering online	2021	Microarray analysis and functional prediction of differentially expressed circular RNAs in acquired middle ear cholesteatoma.		hsa_circRNA_404655			acquired middle ear cholesteatoma 	MONDO:0006533	cholesteatoma of middle ear	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_404655 is significantly up-regulated in acquired middle ear cholesteatoma and is predicted to act in a ceRNA network by binding miRNA-3664-3p, with putative downstream targets including IQGAP3, ROR2, EPHB1, NPM1, RCC2, and NCOA5; m6A sites on this circRNA were predicted with high confidence."	0.4032
34922560	Biomedical engineering online	2021	Microarray analysis and functional prediction of differentially expressed circular RNAs in acquired middle ear cholesteatoma.		hsa_circRNA_000319			acquired middle ear cholesteatoma 	MONDO:0006533	cholesteatoma of middle ear	down-regulated	RT-qPCR; Microarray	hsa_circRNA_000319 is significantly down-regulated in acquired middle ear cholesteatoma and is predicted to participate in a ceRNA network by interacting with hsa-miRNA-4436b-5p; four high-confidence m6A sites were predicted on this circRNA.	0.4032
34925640	Disease markers	2021	CircLDLR Promotes Papillary Thyroid Carcinoma Tumorigenicity by Regulating miR-637/LMO4 Axis.	hsa_circ_0003892	circLDLR 	hsa_circ_LDLR	LDLR	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circLDLR is up-regulated in papillary thyroid carcinoma tissues and cell lines and is mainly localized in the cytoplasm. It promotes PTC malignant phenotypes and tumor growth by sponging miR-637 to relieve repression of LMO4 (circLDLR/miR-637/LMO4 ceRNA axis), and high circLDLR expression is associated with poorer overall survival."	0.8354
34926705	Journal of immunology research	2021	ZNF652-Induced circRHOT1 Promotes SMAD5 Expression to Modulate Tumorigenic Properties and Nature Killer Cell-Mediated Toxicity in Bladder Cancer via Targeting miR-3666.		circRHOT1 	hsa_circ_RHOT1	RHOT1	Bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circRHOT1 is up-regulated in bladder cancer and functions as an oncogenic circRNA by promoting proliferation and migration while reducing NK cell-mediated cytotoxicity. Mechanistically, ZNF652 transcriptionally induces circRHOT1, which sponges miR-3666 to upregulate SMAD5 (ZNF652/circRHOT1/miR-3666/SMAD5)."	0.7435
34927541	Bioengineered	2021	Circular RNA Pvt1 oncogene (CircPVT1) promotes the progression of papillary thyroid carcinoma by activating the Wnt/beta-catenin signaling pathway and modulating the ratio of microRNA-195 (miR-195) to vascular endothelial growth factor A (VEGFA) expression.		circular RNA Pvt1 oncogene  	hsa_circ_PVT1	PVT1	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circPVT1 is up-regulated in papillary thyroid carcinoma tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion). Mechanistically, it sponges miR-195 to increase VEGFA expression and activate Wnt/beta-catenin signaling."	0.7113
34930332	Journal of orthopaedic surgery and research	2021	Ginsenoside Rg3 inhibits osteosarcoma progression by reducing circ_0003074 expression in a miR-516b-5p/KPNA4-dependent manner.	hsa_circ_0003074	circ_0003074	hsa_circ_DHTKD1	DHTKD1	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ_0003074 is up-regulated in osteosarcoma tissues and cells and promotes malignant phenotypes (proliferation, migration/invasion) while inhibiting apoptosis. Mechanistically, it sponges miR-516b-5p to de-repress KPNA4, and Rg3 exerts anti-osteosarcoma effects partly by reducing circ_0003074 and suppressing the circ_0003074/miR-516b-5p/KPNA4 axis."	0.8299
34930344	Journal of orthopaedic surgery and research	2021	"Down-regulation of circ_0058058 suppresses proliferation, angiogenesis and metastasis in multiple myeloma through miR-338-3p/ATG14 pathway."	hsa_circ_0058058	circ_0058058	hsa_circ_ATIC	ATIC	multiple myeloma 	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR	"circ_0058058 is up-regulated in multiple myeloma bone marrow aspirates and MM cell lines and mainly localizes to the cytoplasm. It promotes MM malignant phenotypes (proliferation, angiogenesis, migration/invasion and EMT) and tumor growth by sponging miR-338-3p, thereby increasing ATG14 expression."	0.8175
34930906	Cell death & disease	2021	CircMTO1 suppresses hepatocellular carcinoma progression via the miR-541-5p/ZIC1 axis by regulating Wnt/beta-catenin signaling pathway and epithelial-to-mesenchymal transition.		circMTO1 	hsa_circ_MTO1	MTO1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"circMTO1 is down-regulated in HCC and acts as a tumor suppressor. It sponges miR-541-5p to derepress ZIC1, thereby inhibiting Wnt/beta-catenin signaling and EMT and reducing proliferation, migration, invasion while promoting apoptosis, including in a xenograft model."	0.7759
34931668	Bioscience reports	2022	"Hsa_circ_0076931 suppresses malignant biological properties, down-regulates miR-6760-3p through direct binding, and up-regulates CCBE1 in glioma."	hsa_circ_0076931		hsa_circ_BAI3	BAI3	glioma 	MONDO:0021042	glioma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0076931 is down-regulated in glioma tissues and acts as a tumor suppressor by inhibiting proliferation/migration/invasion and promoting apoptosis. Mechanistically, it sponges miR-6760-3p in an AGO2-dependent manner to relieve repression of CCBE1, and it shows diagnostic potential (ROC AUC 0.882)."	0.8613
34934046	Cell death & disease	2021	Circular RNA circPPP6R3 upregulates CD44 to promote the progression of clear cell renal cell carcinoma via sponging miR-1238-3p.	hsa_circ_0001968	circPPP6R3	hsa_circ_PPP6R3	PPP6R3	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR; RNA-seq	"circPPP6R3 is up-regulated in ccRCC tissues and cell lines and promotes proliferation, migration, invasion, and in vivo tumor growth/metastasis. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-1238-3p to increase CD44, with downstream effects involving EMT-related factors such as MMP9 and Vimentin; high circPPP6R3 is associated with worse DFS."	0.8837
34938195	Frontiers in pharmacology	2021	Long Noncoding RNA and Circular RNA Expression Profiles of Monocyte-Derived Dendritic Cells in Autoimmune Hepatitis.	hsa_circ_0000279		hsa_circ_HPS5	HPS5	Autoimmune hepatitis 	MONDO:0016264	autoimmune hepatitis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000279 is up-regulated in monocyte-derived dendritic cells from AIH patients versus healthy controls (RNA-seq, confirmed by RT-qPCR). The study suggests it may influence DC immune function potentially related to cytokine secretion and cellular metabolism, within constructed circRNA_miRNA_mRNA ceRNA networks, but specific downstream miRNA/mRNA effectors were not established for this circRNA."	0.4032
34938195	Frontiers in pharmacology	2021	Long Noncoding RNA and Circular RNA Expression Profiles of Monocyte-Derived Dendritic Cells in Autoimmune Hepatitis.	hsa_circ_0005076		hsa_circ_MRPS6	MRPS6	Autoimmune hepatitis 	MONDO:0016264	autoimmune hepatitis	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005076 is down-regulated in monocyte-derived dendritic cells from AIH patients versus healthy controls (RNA-seq, confirmed by RT-qPCR). The study hypothesizes it may modulate DC function potentially via cytokine secretion and cellular metabolism and places it within constructed circRNA_miRNA_mRNA ceRNA networks, but does not define a specific validated regulatory axis for this circRNA."	0.4032
34938350	Computational and mathematical methods in medicine	2021	circFAT1(e2) Inhibits Cell Apoptosis and Facilitates Progression in Vascular Smooth Muscle Cells through miR-298/MYB Axis.		circFAT1(e2) 	hsa_circ_FAT1	FAT1	atrial fibrillation	MONDO:0004981	atrial fibrillation	unknown	RT-qPCR	"In human vascular smooth muscle cell lines, circFAT1(e2) promotes cell viability/proliferation and inhibits apoptosis. Mechanistically, it sponges miR-298 to relieve repression of MYB, forming a circFAT1(e2)/miR-298/MYB axis linked by the authors to atrial fibrillation progression."	0.5416
34938598	Molecular therapy. Nucleic acids	2021	circPTEN suppresses colorectal cancer progression through regulating PTEN/AKT pathway.	hsa_circ_0094343	circPTEN	hsa_circ_PTEN	PTEN	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"circPTEN (hsa_circ_0094343) is down-regulated in colorectal cancer and acts as a tumor suppressor. It increases PTEN expression by sponging miR-4470 and also binds TRAF6 to inhibit K63-linked AKT ubiquitination and AKT phosphorylation, thereby suppressing PTEN/AKT signaling, EMT, proliferation, invasion and metastasis while promoting apoptosis. Low circPTEN expression is associated with poor prognosis."	0.8862
34938599	Molecular therapy. Nucleic acids	2021	circRNA-DURSA regulates trophoblast apoptosis via miR-760-HIST1H2BE axis in unexplained recurrent spontaneous abortion.	hsa_circ_0050703	circRNA-0050703 	hsa_circ_WDR62	WDR62	unexplained recurrent spontaneous abortion 	MONDO:0005047	infertility disorder	down-regulated	RT-qPCR; Microarray	"circRNA-DURSA (circRNA-0050703), derived from WDR62 exons, is down-regulated in URSA placental villus and predominantly localizes to the cytoplasm. It suppresses trophoblast apoptosis by acting as a ceRNA sponge for miR-760, thereby relieving miR-760-mediated repression of HIST1H2BE; its knockdown increases apoptosis in vitro and reduces embryo implantation in vivo."	0.8265
34938603	Molecular therapy. Nucleic acids	2022	circRNA-0002109 promotes glioma malignant progression via modulating the miR-129-5P/EMP2 axis.	hsa_circ_0002109	circRNA-0002109 	hsa_circ_MCM10	MCM10	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR; Microarray	"circRNA-0002109 is up-regulated in glioma and mainly localized in the cytoplasm. It promotes glioma proliferation, migration, invasion and EMT by acting as a ceRNA sponge for miR-129-5P, thereby relieving miR-129-5P repression of EMP2 and increasing EMP2 expression; its knockdown suppresses xenograft tumor growth."	0.8516
34939762	Cell journal	2021	Circular RNA_0001073 (circ_0001073) Suppresses The Progression of Non-Small Cell Lung Cancer via miR-582-3p/RGMB Axis.	hsa_circ_0001073	Circ_0001073 	hsa_circ_ACVR2A	ACVR2A	Non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"circ_0001073 is down-regulated in NSCLC and acts as a tumor suppressor by inhibiting proliferation/migration/invasion and promoting apoptosis. Mechanistically, it sponges miR-582-3p to relieve repression of RGMB, forming a circ_0001073/miR-582-3p/RGMB axis; higher circ_0001073 levels correlate with longer patient survival."	0.8252
34945002	Cancers	2021	hsa_circ_0001275 Is One of a Number of circRNAs Dysregulated in Enzalutamide Resistant Prostate Cancer and Confers Enzalutamide Resistance In Vitro.	hsa_circ_0001275	circ1275 Stable	hsa_circ_PLCL2	PLCL2	enzalutamide resistant prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	hsa_circ_0001275 is up-regulated in enzalutamide-resistant LNCaP clones and its stable overexpression increases enzalutamide resistance in vitro. Plasma levels show a PSA-paralleling trend in an MCRPC clinical trial cohort but without statistical significance; mechanism is suggested to involve ceRNA networks but not proven.	0.6875
34945002	Cancers	2021	hsa_circ_0001275 Is One of a Number of circRNAs Dysregulated in Enzalutamide Resistant Prostate Cancer and Confers Enzalutamide Resistance In Vitro.	hsa_circ_0000129		hsa_circ_VPS72	VPS72	enzalutamide resistant prostate cancer	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000129 is experimentally validated as up-regulated in strongly enzalutamide-resistant LNCaP Clone 1 versus control, but no functional or mechanistic role was investigated further in this study."	0.1904
34946819	Genes	2021	Genome-Wide RNA-Sequencing Reveals Massive Circular RNA Expression Changes of the Neurotransmission Genes in the Rat Brain after Ischemia-Reperfusion.		circEce1-13.10	rno_circ_Ece1	Ece1	ischemic brain stroke 	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; RNA-seq	circEce1-13.10 is up-regulated in rat subcortical brain tissue at 24 h after tMCAO-induced ischemia_reperfusion. Its differential expression was identified by RNA-seq and confirmed by real-time RT_PCR.	0.5539
34946819	Genes	2021	Genome-Wide RNA-Sequencing Reveals Massive Circular RNA Expression Changes of the Neurotransmission Genes in the Rat Brain after Ischemia-Reperfusion.		circMvp-7.4	rno_circ_Mvp	Mvp	ischemic brain stroke 	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; RNA-seq	"circMvp-7.4 is up-regulated in rat subcortical brain tissue at 24 h after tMCAO-induced ischemia_reperfusion, supported by RNA-seq and confirmed by real-time RT_PCR."	0.5539
34946819	Genes	2021	Genome-Wide RNA-Sequencing Reveals Massive Circular RNA Expression Changes of the Neurotransmission Genes in the Rat Brain after Ischemia-Reperfusion.		circPlcb1-32.5	rno_circ_Plcb1	Plcb1	ischemic brain stroke 	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR; RNA-seq	"circPlcb1-32.5 is down-regulated in rat brain subcortical tissue after ischemia_reperfusion (tMCAO, 24 h) and was validated by real-time RT_PCR. Bioinformatic network analysis predicts it participates in circRNA_miRNA_mRNA competitive interactions (ceRNA-like regulation) within neurotransmission-related pathways (e.g., glutamatergic synapse), acting as a potential regulatory node."	0.5849
34946819	Genes	2021	Genome-Wide RNA-Sequencing Reveals Massive Circular RNA Expression Changes of the Neurotransmission Genes in the Rat Brain after Ischemia-Reperfusion.		circRgs9-8.2	rno_circ_Rgs9	Rgs9	ischemic brain stroke 	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR; RNA-seq	"circRgs9-8.2 is down-regulated in rat brain subcortical tissue at 24 h after tMCAO-induced ischemia_reperfusion, supported by RNA-seq and confirmed by real-time RT_PCR."	0.5539
34946819	Genes	2021	Genome-Wide RNA-Sequencing Reveals Massive Circular RNA Expression Changes of the Neurotransmission Genes in the Rat Brain after Ischemia-Reperfusion.		circGabra5-6.4	rno_circ_Gabra5	Gabra5	ischemic brain stroke 	MONDO:1060198	ischemic stroke	unknown	RNA-seq	"circGabra5-6.4 was used as an example to validate circRNA circular structure and back-splice junction in rat brain tissue using RNase R treatment, divergent-primer PCR, and Sanger sequencing, supporting the RNA-seq circRNA identification rather than a specific differential-expression claim."	0.527
34948079	International journal of molecular sciences	2021	New Circulating Circular RNAs with Diagnostic and Prognostic Potential in Advanced Colorectal Cancer.	hsa_circ_0001445	hsa_circ_00001445 	hsa_circ_SMARCA5	SMARCA5	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"hsa_circ_0001445 is up-regulated in plasma from advanced CRC patients and shows diagnostic value. In metastatic CRC, higher plasma hsa_circ_0001445 is associated with longer overall survival, supporting its prognostic biomarker potential. The study explored a possible miRNA-sponge relationship with miR-181b but found only a weak trend without significant correlation."	0.5918
34948079	International journal of molecular sciences	2021	New Circulating Circular RNAs with Diagnostic and Prognostic Potential in Advanced Colorectal Cancer.	hsa_circ_0003028	hsa_circ_00003028 	hsa_circ_FUT8	FUT8	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	hsa_circ_0003028 is up-regulated in plasma from CRC patients and shows statistically significant diagnostic accuracy by ROC analysis. Its plasma level is higher in patients with left-sided primary colon tumors compared with right-sided tumors.	0.5727
34948079	International journal of molecular sciences	2021	New Circulating Circular RNAs with Diagnostic and Prognostic Potential in Advanced Colorectal Cancer.	hsa_circ_0007915	hsa_circ_00007915 	hsa_circ_IPO11	IPO11	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	hsa_circ_0007915 is up-regulated in CRC plasma and has the best diagnostic performance among the tested circRNAs. It can differentiate stage III from stage IV CRC by ROC analysis. The study assessed a proposed interaction with miR-106a via correlation analysis but found no significant correlation.	0.6023
34948079	International journal of molecular sciences	2021	New Circulating Circular RNAs with Diagnostic and Prognostic Potential in Advanced Colorectal Cancer.	hsa_circ_0008717	hsa_circ_00008717 	hsa_circ_ABCB10	ABCB10	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"hsa_circ_0008717 is up-regulated in CRC patient plasma and demonstrates diagnostic value by ROC analysis, but it was not reported to have prognostic significance in this study."	0.5727
34950443	Journal of healthcare engineering	2021	"Potential Prognosis and Diagnostic Value of AKT3, LSM12, MEF2C, and RAB30 in Exosomes in Colorectal Cancer on Spark Framework."	hsa_circ_0000284				colorectal cancer 	MONDO:0005575	colorectal cancer	unknown	RNA-seq	"hsa_circ_0000284 was identified as a differentially expressed exosomal circRNA in colorectal cancer using exoRBase data and LIMMA-based differential analysis, but no specific mechanism, targets, or clinical significance were reported for this circRNA individually."	0.1768
34950443	Journal of healthcare engineering	2021	"Potential Prognosis and Diagnostic Value of AKT3, LSM12, MEF2C, and RAB30 in Exosomes in Colorectal Cancer on Spark Framework."	hsa_circ_0000799				colorectal cancer 	MONDO:0005575	colorectal cancer	unknown	RNA-seq	"hsa_circ_0000799 was reported among exosomal circRNAs differentially expressed between CRC and non-tumor samples in exoRBase, but the paper did not provide circRNA-specific direction, mechanism, or clinical association for this circRNA."	0.1768
34950443	Journal of healthcare engineering	2021	"Potential Prognosis and Diagnostic Value of AKT3, LSM12, MEF2C, and RAB30 in Exosomes in Colorectal Cancer on Spark Framework."	hsa_circ_0000567				colorectal cancer 	MONDO:0005575	colorectal cancer	unknown	RNA-seq	"hsa_circ_0000567 was included in the set of differentially expressed exosomal circRNAs in CRC from exoRBase/LIMMA analysis, but the article did not further validate or characterize it."	0.1768
34950443	Journal of healthcare engineering	2021	"Potential Prognosis and Diagnostic Value of AKT3, LSM12, MEF2C, and RAB30 in Exosomes in Colorectal Cancer on Spark Framework."	hsa_circ_0001615				colorectal cancer 	MONDO:0005575	colorectal cancer	unknown	RNA-seq	"hsa_circ_0001615 was identified as a differentially expressed exosomal circRNA in CRC via computational analysis, without downstream functional/clinical validation in this paper."	0.1768
34950443	Journal of healthcare engineering	2021	"Potential Prognosis and Diagnostic Value of AKT3, LSM12, MEF2C, and RAB30 in Exosomes in Colorectal Cancer on Spark Framework."	hsa_circ_0000443				colorectal cancer 	MONDO:0005575	colorectal cancer	unknown	RNA-seq	"hsa_circ_0000443 was listed as a differentially expressed exosomal circRNA in CRC based on exoRBase computational analysis, with no further circRNA-specific interpretation provided."	0.1768
34950443	Journal of healthcare engineering	2021	"Potential Prognosis and Diagnostic Value of AKT3, LSM12, MEF2C, and RAB30 in Exosomes in Colorectal Cancer on Spark Framework."	hsa_circ_0000652				colorectal cancer 	MONDO:0005575	colorectal cancer	unknown	RNA-seq	"hsa_circ_0000652 was one of the exosomal circRNAs flagged as differentially expressed in CRC by LIMMA analysis, but the study did not report its direction of change or mechanistic/clinical links."	0.1768
34950443	Journal of healthcare engineering	2021	"Potential Prognosis and Diagnostic Value of AKT3, LSM12, MEF2C, and RAB30 in Exosomes in Colorectal Cancer on Spark Framework."	hsa_circ_0000019				colorectal cancer 	MONDO:0005575	colorectal cancer	unknown	RNA-seq	"hsa_circ_0000019 was identified computationally as a differentially expressed exosomal circRNA in CRC, but the paper did not provide circRNA-specific functional or clinical conclusions."	0.1768
34950443	Journal of healthcare engineering	2021	"Potential Prognosis and Diagnostic Value of AKT3, LSM12, MEF2C, and RAB30 in Exosomes in Colorectal Cancer on Spark Framework."	hsa_circ_0000798				colorectal cancer 	MONDO:0005575	colorectal cancer	unknown	RNA-seq	"hsa_circ_0000798 was computationally identified among differentially expressed exosomal circRNAs in CRC, without further circRNA-specific validation or mechanistic analysis."	0.1768
34950443	Journal of healthcare engineering	2021	"Potential Prognosis and Diagnostic Value of AKT3, LSM12, MEF2C, and RAB30 in Exosomes in Colorectal Cancer on Spark Framework."	hsa_circ_0001860				colorectal cancer 	MONDO:0005575	colorectal cancer	unknown	RNA-seq	"hsa_circ_0001860 was reported as a differentially expressed exosomal circRNA in CRC from database analysis, but no direct functional mechanism or clinical prognostic/diagnostic performance was provided for it."	0.1768
34950443	Journal of healthcare engineering	2021	"Potential Prognosis and Diagnostic Value of AKT3, LSM12, MEF2C, and RAB30 in Exosomes in Colorectal Cancer on Spark Framework."	hsa_circ_0000339				colorectal cancer 	MONDO:0005575	colorectal cancer	unknown	RNA-seq	"hsa_circ_0000339 was included in the CRC exosomal differentially expressed circRNA set from exoRBase/LIMMA, with no additional circRNA-specific findings reported."	0.1768
34950443	Journal of healthcare engineering	2021	"Potential Prognosis and Diagnostic Value of AKT3, LSM12, MEF2C, and RAB30 in Exosomes in Colorectal Cancer on Spark Framework."	hsa_circ_0000419				colorectal cancer 	MONDO:0005575	colorectal cancer	unknown	RNA-seq	hsa_circ_0000419 was reported as part of the differentially expressed exosomal circRNA list in CRC but was not individually characterized further.	0.1768
34950443	Journal of healthcare engineering	2021	"Potential Prognosis and Diagnostic Value of AKT3, LSM12, MEF2C, and RAB30 in Exosomes in Colorectal Cancer on Spark Framework."	hsa_circ_0000705				colorectal cancer 	MONDO:0005575	colorectal cancer	unknown	RNA-seq	hsa_circ_0000705 was identified in silico as one of 13 differentially expressed exosomal circRNAs in CRC; no circRNA-specific mechanistic axis was reported.	0.1768
34950443	Journal of healthcare engineering	2021	"Potential Prognosis and Diagnostic Value of AKT3, LSM12, MEF2C, and RAB30 in Exosomes in Colorectal Cancer on Spark Framework."	hsa_circ_0000524				colorectal cancer 	MONDO:0005575	colorectal cancer	unknown	RNA-seq	"hsa_circ_0000524 was listed among differentially expressed exosomal circRNAs in CRC identified by LIMMA, but no circRNA-specific direction, interaction partners, or clinical utility metrics were provided."	0.1768
34950658	Frontiers in cell and developmental biology	2021	A Novel Circular RNA CircRFX3 Serves as a Sponge for MicroRNA-587 in Promoting Glioblastoma Progression via Regulating PDIA3.		hsa_circRFX3_003 	hsa_circ_RFX3	RFX3	glioblastoma 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; Microarray	"circRFX3 (hsa_circRFX3_003) is up-regulated in glioblastoma tissues and cell lines and promotes GBM cell proliferation, invasion, migration, and in vivo tumor growth. Mechanistically, it functions as a ceRNA sponging miR-587 to upregulate PDIA3 and activate the Wnt/beta-catenin (miR-587/PDIA3/beta-catenin) axis, and higher circRFX3 is associated with worse prognosis."	0.8684
34952600	Journal of translational medicine	2021	Analysis and validation of m6A regulatory network: a novel circBACH2/has-miR-944/HNRNPC axis in breast cancer progression.	hsa_circ_0001625	circBACH2	hsa_circ_BACH2	BACH2	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	circBACH2 (hsa_circ_0001625) is up-regulated in breast cancer and promotes breast cancer cell proliferation. It functions as a ceRNA by sponging hsa-miR-944 to increase HNRNPC expression and activate MAPK/ERK signaling.	0.5008
34952991	Journal of clinical laboratory analysis	2022	Hsa_circ_0000437 upregulates and promotes disease progression in rheumatic valvular heart disease.	hsa_circ_0000437		hsa_circ_CORO1C	CORO1C	rheumatic valvular heart disease 	MONDO:0006955	rheumatic heart disease	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000437 (from the CORO1C locus) is up-regulated in the plasma of RVHD patients and shows strong diagnostic performance by ROC analysis. In hVICs, it promotes proliferation and migration, inhibits apoptosis, and affects cell-cycle distribution; it is cytoplasm-localized and predicted to act as a miRNA sponge (e.g., hsa-miR-502-5p and let-7 family members)."	0.7486
34956563	Journal of healthcare engineering	2021	CircRNA RERE Promotes the Oxidative Stress-Induced Apoptosis and Autophagy of Nucleus Pulposus Cells through the miR-299-5p/Galectin-3 Axis.		circ_RERE	hsa_circ_RERE	RERE	intervertebral disc degeneration 	MONDO:0011385	intervertebral disk degenerative disorder	up-regulated	RT-qPCR; Microarray	circ_RERE is up-regulated in IDD NP tissue and in H2O2-treated human NP cells. It promotes oxidative stress-induced NP cell apoptosis and autophagy by sponging miR-299-5p and thereby increasing galectin-3 expression.	0.5997
34957096	Frontiers in cell and developmental biology	2021	Integral Analyses of Competing Endogenous RNA Mechanisms and DNA Methylation Reveal Regulatory Mechanisms in Osteosarcoma.	hsa_circ_0001753		hsa_circ_CREB3L2	CREB3L2	Osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0001753 is down-regulated in osteosarcoma cell lines versus osteoblasts. The study proposes and validates a ceRNA network where hsa_circ_0001753 interacts with hsa-miR-760 and is linked to reduced CD74 expression, suggesting a role in osteosarcoma pathogenesis and potential diagnostic/therapeutic relevance."	0.4997
34957102	Frontiers in cell and developmental biology	2021	Hsa_circ_0062682 Promotes Serine Metabolism and Tumor Growth in Colorectal Cancer by Regulating the miR-940/PHGDH Axis.	hsa_circ_0062682		hsa_circ_TPST2	TPST2	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"In colorectal cancer, circ_0062682 is upregulated and promotes tumor growth by enhancing serine biosynthesis. It mainly functions in the cytoplasm as a ceRNA that sponges miR-940, thereby releasing PHGDH expression and increasing serine-related metabolic outputs (e.g., NADPH/GSH) that support proliferation and survival under stress."	0.8673
34966440	Computational and mathematical methods in medicine	2021	Integrated Analysis of Circular RNA-Associated ceRNA Network Reveals Potential circRNA Biomarkers in Human Breast Cancer.	hsa_circ_0000069				breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	hsa_circ_0000069 was identified as a differentially expressed circRNA in breast cancer and was validated to be up-regulated in BRCA tumor tissues versus adjacent nontumor tissues by qRT-PCR.	0.4032
34966440	Computational and mathematical methods in medicine	2021	Integrated Analysis of Circular RNA-Associated ceRNA Network Reveals Potential circRNA Biomarkers in Human Breast Cancer.	hsa_circ_0000518				breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	hsa_circ_0000518 was identified as a differentially expressed circRNA in breast cancer and was validated to be up-regulated in BRCA tumor tissues versus adjacent nontumor tissues by qRT-PCR.	0.4032
34966440	Computational and mathematical methods in medicine	2021	Integrated Analysis of Circular RNA-Associated ceRNA Network Reveals Potential circRNA Biomarkers in Human Breast Cancer.	hsa_circ_0000520				breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	has_circ_0000520 was identified as a differentially expressed circRNA in breast cancer and was validated to be up-regulated in BRCA tumor tissues versus adjacent nontumor tissues by qRT-PCR.	0.4032
34966440	Computational and mathematical methods in medicine	2021	Integrated Analysis of Circular RNA-Associated ceRNA Network Reveals Potential circRNA Biomarkers in Human Breast Cancer.	hsa_circ_0000977				breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	has_circ_0000977 was identified as a differentially expressed circRNA in breast cancer and was validated to be down-regulated in BRCA tumor tissues versus adjacent nontumor tissues by qRT-PCR.	0.4032
34966683	Frontiers in oncology	2021	Circular RNA CircPVT1 Inhibits 5-Fluorouracil Chemosensitivity by Regulating Ferroptosis Through MiR-30a-5p/FZD3 Axis in Esophageal Cancer Cells.		circPVT1 	hsa_circ_PVT1	PVT1	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"circPVT1 is upregulated in 5-FU-resistant ESCC cells and promotes chemoresistance. Mechanistically, circPVT1 sponges miR-30a-5p to upregulate FZD3, activating Wnt/beta-catenin signaling and suppressing ferroptosis (via GPX4/SLC7A11), thereby reducing 5-FU chemosensitivity."	0.6287
34967281	Bioengineered	2022	Circ_0005320 promotes oral squamous cell carcinoma tumorigenesis by sponging microRNA-486-3p and microRNA-637.	hsa_circ_0005320		hsa_circ_SEPT9	SEPT9	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circ_0005320 is up-regulated in OSCC tissues and cell lines and functions as an oncogenic circRNA. It sponges miR-486-3p and miR-637, thereby promoting malignant phenotypes and activating the JAK2/STAT3 signaling pathway; its knockdown suppresses tumor growth in a nude mouse xenograft model."	0.8327
34967761	Aging	2021	Knockdown hsa_circ_0063526 inhibits endometriosis progression via regulating the miR-141-5p / EMT axis and downregulating estrogen receptors.	hsa_circ_0063526		hsa_circ_RanGAP1	RanGAP1	endometriosis 	MONDO:0005133	endometriosis	up-regulated	RT-qPCR	"hsa_circ_0063526 is up-regulated in endometriosis ectopic lesions. It promotes endometriosis cell proliferation, invasion and migration by binding miR-141-5p and enhancing EMT-related changes, and its knockdown reduces lesion size and suppresses estrogen receptor expression in vivo."	0.713
34972532	"Journal of biological research (Thessalonike, Greece)"	2021	Circ_0000620 acts as an oncogenic factor in gastric cancer through regulating MMP2 expression via sponging miR-671-5p.	hsa_circ_0000620		hsa_circ_AAGAB	AAGAB	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_0000620 is upregulated in gastric cancer and mainly localized in the cytoplasm. It promotes malignant phenotypes (proliferation, migration/invasion, and angiogenesis) and tumor growth by acting as a sponge for miR-671-5p, thereby increasing MMP2 expression, and high circ_0000620 is associated with poorer survival."	0.8325
34974169	Biomedical journal	2022	Circ_0091579 exerts an oncogenic role in hepatocellular carcinoma via mediating miR-136-5p/TRIM27.	hsa_circ_0091579		hsa_circ_GPC3	GPC3	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"Circ_0091579 is up-regulated in hepatocellular carcinoma and is associated with poorer survival. Functionally, it promotes HCC cell proliferation, migration/invasion, cell-cycle progression and EMT while inhibiting apoptosis, and it enhances xenograft tumor growth. Mechanistically, circ_0091579 mainly localizes to the cytoplasm and acts as a ceRNA sponge for miR-136-5p to up-regulate TRIM27."	0.8498
34974791	Bioengineered	2022	"Circular RNA protein tyrosine kinase 2 (circPTK2) promotes colorectal cancer proliferation, migration, invasion and chemoresistance."	hsa_circ_0003221		hsa_circ_PTK2	PTK2	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circPTK2 (hsa_circ_0003221) is up-regulated in CRC tissues/cells and is associated with liver metastasis, advanced clinical stage, and chemoresistance. Functionally, circPTK2 promotes proliferation, migration, invasion and resistance to 5-FU/oxaliplatin. Mechanistically, circPTK2 sponges miR-136-5p to increase YTHDF1 and activate Wnt/beta-catenin signaling, and circPTK2 knockdown suppresses xenograft tumor growth."	0.7587
34976014	Frontiers in genetics	2021	Downregulation of hsa_circRNA_0001400 Helps to Promote Cell Apoptosis Through Disruption of the circRNA_0001400-miR-326 Sponge in Cervical Cancer Cells.	hsa_circ_0001400				cervical cancer	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circRNA_0001400 is up-regulated in cervical cancer and functions as a miR-326 sponge to sustain Akt/AKT2 expression and p-Akt signaling, thereby promoting tumor progression. Silencing hsa_circRNA_0001400 increases miR-326, suppresses Akt, enhances apoptosis, inhibits migration, and reduces xenograft growth/angiogenesis."	0.6004
34976133	Experimental and therapeutic medicine	2022	Role of hsa_circ_0066966 in proliferation and migration of hepatitis B virus-related liver cancer cells.	hsa_circ_0066966		hsa_circ_GOLGB1	GOLGB1	HBV-positive liver cancer 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0066966 is up-regulated in HBV-positive liver cancer cell lines and promotes cell proliferation and migration. Its interaction with multiple miRNAs (e.g., hsa-miR-3619-5p, hsa-miR-214-3p, hsa-miR-646) was predicted bioinformatically, but downstream targets/pathways were not experimentally confirmed."	0.4852
34976169	Journal of Cancer	2022	Hsa_circ_0074298 promotes pancreatic cancer progression and resistance to gemcitabine by sponging miR-519 to target SMOC.	hsa_circ_0074298		hsa_circ_HARS	HARS	pancreatic cancer	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; ISH	"hsa_circ_0074298 (host gene HARS) is up-regulated in pancreatic cancer tissues and cell lines, mainly localizes to the cytoplasm, and promotes tumor proliferation, migration/invasion, and gemcitabine resistance. Mechanistically, it acts as a ceRNA to sponge miR-519d, thereby upregulating SMOC2 and contributing to malignant progression and chemoresistance; it also shows potential diagnostic value (ROC AUC 0.676)."	0.786
34976440	Molecular therapy. Nucleic acids	2022	hsa_circ_0005358 suppresses cervical cancer metastasis by interacting with PTBP1 protein to destabilize CDCP1 mRNA.	hsa_circ_0005358		hsa_circ_Gli1	Gli1	cervical cancer 	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR; Northern Blot; RNA-seq	"hsa_circ_0005358 is down-regulated in cervical cancer, especially in extracervical metastasis_associated tissues, and functions as a metastasis suppressor. It binds PTBP1 (via sequence 215_224) to block PTBP1-mediated stabilization of CDCP1 mRNA, promoting CDCP1 mRNA decay and lowering CDCP1 protein, thereby inhibiting migration/invasion and in vivo metastasis."	0.8483
34977002	Frontiers in cell and developmental biology	2021	Hsa_circ_0000652 Aggravates Inflammation by Activation of Macrophages and Enhancement of OX40/OX40L Interaction in Ankylosing Spondylitis.	hsa_circ_0000652		hsa_circ_IQGAP1	IQGAP1	ankylosing spondylitis 	MONDO:0005306	ankylosing spondylitis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000652 is upregulated in PBMCs from ankylosing spondylitis patients and correlates with disease activity. It promotes macrophage proliferation and pro-inflammatory cytokine secretion while inhibiting apoptosis, and it enhances OX40/OX40L-mediated macrophage_CD4+ T-cell inflammatory interaction by sponging hsa-miR-1179 to upregulate OX40L."	0.8412
34980005	BMC cancer	2022	Plasma circN4BP2L2 is a promising novel diagnostic biomarker for epithelial ovarian cancer.		circN4BP2L2	hsa_circ_N4BP2L2	N4BP2L2	epithelial ovarian cancer 	MONDO:0005140	ovarian carcinoma	down-regulated	RT-qPCR	"circN4BP2L2 is significantly down-regulated in plasma, tumor tissues, and EOC cell lines, and its decrease is associated with more aggressive clinicopathologic features. Functionally, circN4BP2L2 suppresses EOC cell migration and invasion in vitro and shows diagnostic value (including early-stage EOC) by ROC analysis. A potential circN4BP2L2-miRNA interaction is suggested by prediction software, but the mechanism is not experimentally validated."	0.648
34980129	Molecular cancer	2022	circCDYL2 promotes trastuzumab resistance via sustaining HER2 downstream signaling in breast cancer.	hsa_circ_0004087		hsa_circ_CDYL2	CDYL2	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circCDYL2 is up-regulated in trastuzumab-resistant HER2+ breast cancer and promotes resistance in vitro and in vivo. It binds GRB7 and FAK to form a scaffold complex, stabilizes GRB7 by reducing ubiquitination (linked to Pin1), and sustains downstream PI3K/AKT and ERK signaling. High circCDYL2 predicts higher recurrence and poorer DFS/OS after anti-HER2 therapy."	0.8861
34980149	Journal of translational medicine	2022	Circulating exosomal hsa_circRNA_0039480 is highly expressed in gestational diabetes mellitus and may be served as a biomarker for early diagnosis of GDM.	hsa_circ_0039480				gestational diabetes mellitus 	MONDO:0005406	gestational diabetes	up-regulated	RT-qPCR; Microarray	"Plasma exosomal hsa_circRNA_0039480 is up-regulated in GDM across pregnancy stages and correlates positively with OGTT glucose levels (second trimester). It shows diagnostic performance for distinguishing GDM from NGT, supporting its potential as an early, non-invasive biomarker."	0.5047
34980149	Journal of translational medicine	2022	Circulating exosomal hsa_circRNA_0039480 is highly expressed in gestational diabetes mellitus and may be served as a biomarker for early diagnosis of GDM.	hsa_circ_0026497				gestational diabetes mellitus 	MONDO:0005406	gestational diabetes	up-regulated	RT-qPCR; Microarray	"Plasma exosomal hsa_circRNA_0026497 is increased in GDM in some stages (notably second trimester; also higher before delivery in GDM). Its standalone early diagnostic performance is limited, but it correlates with hsa_circRNA_0039480 in first-trimester GDM and contributes to improved discrimination when combined with hsa_circRNA_0039480."	0.5047
34982022	Bioengineered	2022	Circular RNA circ-LARP1B contributes to cutaneous squamous cell carcinoma progression by targeting microRNA-515-5p/TPX2 microtubule nucleation factor axis.	hsa_circ_0070934	circ-LARP1B 	hsa_circ_LARP1B	LARP1B	cutaneous squamous cell carcinoma 	MONDO:0002529	skin squamous cell carcinoma	up-regulated	RT-qPCR	"circ-LARP1B is up-regulated in cutaneous squamous cell carcinoma and promotes malignant phenotypes (proliferation/colony formation, migration/invasion, cell-cycle progression, and glycolysis) while inhibiting apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-515-5p to increase TPX2 expression and activate PI3K/AKT signaling, and its knockdown suppresses xenograft tumor growth."	0.8039
34983293	"Cell cycle (Georgetown, Tex.)"	2022	Identifying a novel IRF3/circUHRF1/miR-1306-5p/ARL4C axis in pancreatic ductal adenocarcinoma progression.	hsa_circ_0048677	circUHRF1	hsa_circ_UHRF1	UHRF1	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR	"circUHRF1 is up-regulated in PDAC tissues and cell lines and mainly localizes in the cytoplasm. It promotes PDAC proliferation, migration, EMT and tumor growth while inhibiting apoptosis by sponging miR-1306-5p to upregulate ARL4C. Its expression is positively regulated by the transcription factor IRF3."	0.8279
34983537	Molecular cancer	2022	CircRTN4 promotes pancreatic cancer progression through a novel CircRNA-miRNA-lncRNA pathway and stabilizing epithelial-mesenchymal transition protein.	hsa_circ_0001006	circRTN4	hsa_circ_RTN4	RTN4	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circRTN4 is up-regulated in PDAC tumors and promotes malignant phenotypes (proliferation, migration/invasion, tumor growth and liver metastasis). Mechanistically, it sponges miR-497-5p to increase oncogenic lncRNA HOTTIP expression and also binds RAB11FIP1 to inhibit its ubiquitination and stabilize the protein, thereby promoting EMT marker expression."	0.8784
34983607	Journal of ovarian research	2022	Circ_0078607 inhibits the progression of ovarian cancer via regulating the miR-32-5p/SIK1 network.	hsa_circ_0078607				ovarian cancer 	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR	"circ_0078607 is down-regulated in ovarian cancer tissues and cell lines and functions as a tumor suppressor. It inhibits proliferation/migration/invasion and promotes apoptosis by sponging miR-32-5p to upregulate SIK1 (circ_0078607/miR-32-5p/SIK1 axis), reducing tumorigenesis in xenograft models."	0.713
34983617	Breast cancer research : BCR	2022	Circular RNA circCCDC85A inhibits breast cancer progression via acting as a miR-550a-5p sponge to enhance MOB1A expression.	hsa_circ_0120472	circCCDC85A	hsa_circ_CCDC85A	CCDC85A	breast cancer	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; ISH	"circCCDC85A is down-regulated in breast cancer and suppresses malignant phenotypes (proliferation, migration, invasion). It primarily functions as a ceRNA by sponging miR-550a-5p, thereby relieving miR-550a-5p-mediated repression and increasing MOB1A expression, with links to Hippo signaling components via the miR-550a-5p target MOB1A."	0.8231
34985013	Chinese medical journal	2022	Circular BANP knockdown inhibits the malignant progression of residual hepatocellular carcinoma after insufficient radiofrequency ablation.		circ-BANP 	hsa_circ_BANP	BANP	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ-BANP is up-regulated in HCC (especially residual tumors after insufficient RFA) and promotes malignant behaviors. Mechanistically, it sponges let-7f-5p to de-repress TLR4, activating the TLR4/STAT3 pathway to enhance proliferation, migration/invasion, angiogenesis, and EMT; circ-BANP knockdown suppresses these phenotypes in vitro and in a xenograft model."	0.7045
34985193	Thoracic cancer	2022	Circ_0026134 promotes NSCLC progression by the miR-3619-5p/CHAF1B axis.	hsa_circ_0026134	circ_0026134 	hsa_circ_TUBA1C	TUBA1C	Non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0026134 is up-regulated in NSCLC tissues/cells and promotes malignant phenotypes (proliferation/colony formation, migration, invasion, glycolysis) while suppressing apoptosis. Mechanistically, it sponges miR-3619-5p to increase CHAF1B, and its knockdown inhibits xenograft tumor growth."	0.7524
34986849	Molecular cancer	2022	Hsa_circ_0003258 promotes prostate cancer metastasis by complexing with IGF2BP3 and sponging miR-653-5p.	hsa_circ_0003258		hsa_circ_ZNF652	ZNF652	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; ISH; RNA-seq; Microarray	"hsa_circ_0003258 is up-regulated in prostate cancer tissues and promotes migration/metastasis. It sponges miR-653-5p to increase ARHGAP5 and also forms a cytoplasmic complex with IGF2BP3 to stabilize HDAC4 mRNA, activating ERK/MAPK-driven EMT."	0.8983
34987549	Frontiers in genetics	2021	Systematic Analysis of mRNAs and ncRNAs in BMSCs of Senile Osteoporosis Patients.		circRNA008876 			senile osteoporosis 	MONDO:0005298	osteoporosis	down-regulated	RT-qPCR; RNA-seq	"circRNA008876 is down-regulated in BMSCs from senile osteoporosis patients and promotes osteogenic differentiation. Mechanistically, it directly binds and sponges miR-150-5p, thereby affecting osteogenesis-related gene expression; pathway enrichment of the network implicated p53 and Hedgehog signaling."	0.6676
34988135	Frontiers in cardiovascular medicine	2021	Expression Profiles of Circular RNA in Aortic Vascular Tissues of Spontaneously Hypertensive Rats.	rno_circ_0005818	rno_circRNA_0005818	rno_circ_Dnajc1	Dnajc1	hypertension	MONDO:0005044	hypertensive disorder	up-regulated	RT-qPCR; RNA-seq	"rno_circRNA_0005818 is up-regulated in SHR thoracic aorta and was validated by RT-PCR. It is predicted to act as a ceRNA by sponging miRNAs (e.g., rno-miR-615 and miR-10b-5p) to affect hub mRNAs such as NOTCH1 and STAT3 in hypertensive vascular injury."	0.4851
34988135	Frontiers in cardiovascular medicine	2021	Expression Profiles of Circular RNA in Aortic Vascular Tissues of Spontaneously Hypertensive Rats.	rno_circ_0005304	rno_circRNA_0005304			hypertension	MONDO:0005044	hypertensive disorder	up-regulated	RT-qPCR; RNA-seq	"rno_circRNA_0005304 is up-regulated in SHR aorta and validated by RT-PCR. It is predicted to participate in a ceRNA network by binding rno-miR-194-5p, rno-miR-93-3p and rno-miR-320-5p, potentially contributing to hypertensive vascular remodeling."	0.4851
34988135	Frontiers in cardiovascular medicine	2021	Expression Profiles of Circular RNA in Aortic Vascular Tissues of Spontaneously Hypertensive Rats.	rno_circ_0005506	rno_circRNA_0005506	rno_circ_Ryr2	Ryr2	hypertension	MONDO:0005044	hypertensive disorder	up-regulated	RT-qPCR; RNA-seq	"rno_circRNA_0005506 (host gene Ryr2) is up-regulated in SHR aorta and validated by RT-PCR. It is predicted to bind rno-miR-122-3p, rno-miR-298-5p and rno-miR-509-3p as part of a ceRNA network implicated in hypertensive vascular remodeling."	0.4851
34988135	Frontiers in cardiovascular medicine	2021	Expression Profiles of Circular RNA in Aortic Vascular Tissues of Spontaneously Hypertensive Rats.	rno_circ_0009301	rno_circRNA_0009301			hypertension	MONDO:0005044	hypertensive disorder	up-regulated	RT-qPCR; RNA-seq	"rno_circRNA_0009301 is up-regulated in SHR aorta and validated by RT-PCR. It is predicted to participate in a ceRNA network by interacting with rno-miR-628, rno-miR-676 and rno-miR-873-5p, potentially contributing to hypertensive aortic remodeling."	0.4851
34988135	Frontiers in cardiovascular medicine	2021	Expression Profiles of Circular RNA in Aortic Vascular Tissues of Spontaneously Hypertensive Rats.	rno_circ_0009197	rno_circRNA_0009197	rno_circ_Cdh23	Cdh23	hypertension	MONDO:0005044	hypertensive disorder	down-regulated	RT-qPCR; RNA-seq	rno_circRNA_0009197 (host gene Cdh23) is down-regulated in SHR aorta and validated by RT-PCR. It is highlighted in a predicted ceRNA axis rno_circRNA_0009197/miR-509-5p/FOXO3 that may be involved in hypertensive vascular injury and dysfunction.	0.4851
34989110	The Kaohsiung journal of medical sciences	2022	eIF4A3-induced circWAC promotes breast cancer progression through mediating miR-599/E2F3 axis.	hsa_circ_0007503	circ_0007503 	hsa_circ_WAC	WAC	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circWAC is up-regulated in breast cancer and functions as an oncogenic circRNA. It promotes proliferation, migration, invasion, glycolysis and tumor growth while inhibiting apoptosis, mainly by sponging miR-599 to increase E2F3; eIF4A3 positively regulates circWAC biogenesis/expression."	0.8789
34989145	Thoracic cancer	2022	"Circ_0007385 regulates cell proliferation, apoptosis and stemness via targeting miR-493-3p/RAB22A axis in non-small cell lung cancer."	hsa_circ_0007385	Circ_0007385 			non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"Circ_0007385 is up-regulated in NSCLC tissues/cells and mainly localizes to the cytoplasm. It promotes NSCLC cell proliferation and stemness and inhibits apoptosis, at least in part by sponging miR-493-3p to increase RAB22A expression, and its knockdown suppresses xenograft tumor growth."	0.734
34992655	Journal of oncology	2021	CircRNA ANXA2 Promotes Lung Cancer Proliferation and Metastasis by Upregulating PDPK1 Expression.		circRNA ANXA2 	hsa_circ_ANXA2	ANXA2	lung cancer 	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circANXA2 is upregulated in lung adenocarcinoma tissues and lung cancer cell lines and is mainly localized in the cytoplasm. It promotes malignant phenotypes (proliferation, clonogenesis and EMT) and inhibits apoptosis by sponging miR-33a-5p, thereby increasing PDPK1 expression."	0.7369
34992688	Oncology letters	2022	circular RNAs 0000515 and 0011385 as potential biomarkers for disease monitoring and determining prognosis in pancreatic ductal adenocarcinoma.	hsa_circ_0000515	circ_0000515	hsa_circ_RPPH1	RPPH1	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circ_0000515 is upregulated in PDAC tissues versus paired adjacent normal tissues. High tumor circ_0000515 expression correlates with more advanced staging and shorter overall survival, supporting its potential as a prognostic biomarker in PDAC."	0.636
34992688	Oncology letters	2022	circular RNAs 0000515 and 0011385 as potential biomarkers for disease monitoring and determining prognosis in pancreatic ductal adenocarcinoma.	hsa_circ_0000517	circ_0000517	hsa_circ_RPPH1	RPPH1	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; Microarray	circ_0000517 is significantly upregulated in PDAC tissues compared with paired adjacent normal tissues and shows discriminatory ability between tumor and adjacent tissue by ROC analysis. It was not associated with overall survival in this cohort.	0.636
34992688	Oncology letters	2022	circular RNAs 0000515 and 0011385 as potential biomarkers for disease monitoring and determining prognosis in pancreatic ductal adenocarcinoma.	hsa_circ_0000520	circ_0000520	hsa_circ_RPPH1	RPPH1	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circ_0000520 is upregulated in PDAC tissues relative to paired adjacent normal tissues. Its expression is positively associated with tumor stage and it shows diagnostic discrimination by ROC analysis, but it is not associated with overall survival in this study."	0.636
34992688	Oncology letters	2022	circular RNAs 0000515 and 0011385 as potential biomarkers for disease monitoring and determining prognosis in pancreatic ductal adenocarcinoma.	hsa_circ_0000514	circ_0000514 	hsa_circ_RPPH1	RPPH1	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circ_0000514 is upregulated in PDAC tissues compared with paired adjacent normal tissues. Higher circ_0000514 expression is positively correlated with T stage and it shows diagnostic discrimination by ROC analysis, but it is not associated with overall survival in this cohort."	0.636
34992688	Oncology letters	2022	circular RNAs 0000515 and 0011385 as potential biomarkers for disease monitoring and determining prognosis in pancreatic ductal adenocarcinoma.	hsa_circ_0011385	circ_0011385	hsa_circ_EIF3I	EIF3I	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circ_0011385 is upregulated in PDAC tissues compared with paired adjacent normal tissues. High circ_0011385 expression is associated with more advanced tumor stage and shorter overall survival, indicating prognostic potential in PDAC."	0.636
34992688	Oncology letters	2022	circular RNAs 0000515 and 0011385 as potential biomarkers for disease monitoring and determining prognosis in pancreatic ductal adenocarcinoma.	hsa_circ_0055033	circ_0055033 	hsa_circ_ANTXR1	ANTXR1	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circ_0055033 is significantly upregulated in PDAC tissues versus paired adjacent normal tissues. Its diagnostic performance in distinguishing tumor from adjacent tissue is modest (ordinary AUC), and it is not associated with overall survival in this cohort."	0.636
34992688	Oncology letters	2022	circular RNAs 0000515 and 0011385 as potential biomarkers for disease monitoring and determining prognosis in pancreatic ductal adenocarcinoma.	hsa_circ_0072088	circ_0072088	hsa_circ_ZFR	ZFR	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circ_0072088 is upregulated in PDAC tissues compared with paired adjacent normal tissues. Its expression correlates with more advanced T stage/TNM stage and it shows good diagnostic discrimination by ROC analysis, but it is not associated with overall survival in this cohort."	0.636
34992688	Oncology letters	2022	circular RNAs 0000515 and 0011385 as potential biomarkers for disease monitoring and determining prognosis in pancreatic ductal adenocarcinoma.	hsa_circ_0003528	circ_0003528	hsa_circ_SEC24A	SEC24A	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circ_0003528 is significantly upregulated in PDAC tissues versus paired adjacent normal tissues. Its diagnostic performance is modest (ordinary AUC), and it is not associated with overall survival in this cohort."	0.636
34996416	BMC pulmonary medicine	2022	A novel circ_MACF1/miR-942-5p/TGFBR2 axis regulates the functional behaviors and drug sensitivity in gefitinib-resistant non-small cell lung cancer cells.	hsa_circ_0011780	circ_MACF1	hsa_circ_MACF1	MACF1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"circ_MACF1 is down-regulated in gefitinib-resistant NSCLC (cells and patient plasma). Restoring circ_MACF1 suppresses malignant behaviors and enhances gefitinib sensitivity by sponging miR-942-5p and thereby increasing TGFBR2 expression, leading to reduced tumor growth under gefitinib in vivo."	0.8175
35000524	Bioengineered	2022	Circular RNA Plasmacytoma Variant Translocation 1 (CircPVT1) knockdown ameliorates hypoxia-induced bladder fibrosis by regulating the miR-203/Suppressor of Cytokine Signaling 3 (SOCS3) signaling axis.		CircPVT1 	hsa_circ_PVT1	PVT1	bladder outlet obstruction 	MONDO:0006679	bladder neck obstruction	up-regulated	RT-qPCR; Microarray	"circPVT1 is upregulated in BOO-associated bladder remodeling and in hypoxia-induced fibrotic BSMCs. It promotes bladder hypertrophy/fibrosis by sponging miR-203, thereby increasing SOCS3 expression; circPVT1 knockdown ameliorates fibrotic markers and cellular injury phenotypes."	0.6829
35000535	Bioengineered	2022	"Circ_0017639 facilitates proliferative, migratory, and invasive potential of non-small cell lung cancer (NSCLC) cells via PI3K/AKT signaling pathway."	hsa_circ_0017639	circ_0017639 	hsa_circ_SFMBT2	SFMBT2	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0017639 is up-regulated in NSCLC tissues and cell lines and functions as an oncogenic circRNA that promotes proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, it enhances PI3K/AKT signaling activity (increased PI3K/AKT phosphorylation), and AKT activation (SC97) rescues the inhibitory effects of circ_0017639 knockdown."	0.7451
35002298	International journal of general medicine	2021	Correlation Analysis of circRNA Circ_0071662 in Diagnosis and Prognosis of Esophageal Squamous Cell Carcinoma.	hsa_circ_0071662	circ_0071662			esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	RT-qPCR	"circ_0071662 is down-regulated in ESCC plasma and tumor tissues. Lower plasma circ_0071662 levels discriminate ESCC from EU/GERD/healthy controls and are associated with worse patient survival, supporting its potential as a diagnostic and prognostic biomarker."	0.4992
35002514	International journal of biological sciences	2022	CircCCNB1 silencing acting as a miR-106b-5p sponge inhibited GPM6A expression to promote HCC progression by enhancing DYNC1I1 expression and activating the AKT/ERK signaling pathway.	hsa_circ_0001495	circCCNB1	hsa_circ_CCNB1	CCNB1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"In HCC, circCCNB1 is down-regulated and functions as a miR-106b-5p sponge to maintain GPM6A expression. Silencing circCCNB1 lowers GPM6A, elevates DYNC1I1, activates AKT/ERK phosphorylation, and promotes cell-cycle progression, proliferation, invasion/metastasis, and xenograft tumor growth."	0.7859
35002529	International journal of biological sciences	2022	CircCDK14 Promotes Tumor Progression and Resists Ferroptosis in Glioma by Regulating PDGFRA.	hsa_circ_0001721	circCDK14	hsa_circ_CDK14	CDK14	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR; RNA-seq	"circCDK14 (hsa_circ_0001721), derived from CDK14, is up-regulated in glioma tissues/cell lines and its high expression predicts worse OS. Functionally, it promotes glioma proliferation, migration, invasion and xenograft growth. Mechanistically, circCDK14 mainly localizes in the cytoplasm and sponges miR-3938 to increase PDGFRA, thereby enhancing malignant behavior and decreasing sensitivity to erastin-induced ferroptosis, partly via PDGFRalpha signaling affecting GPX4/SLC7A11."	0.8658
35002536	Mediators of inflammation	2021	CircN4bp1 Facilitates Sepsis-Induced Acute Respiratory Distress Syndrome through Mediating Macrophage Polarization via the miR-138-5p/EZH2 Axis.		circN4bp1	mmu_circ_N4bp1	N4bp1	sepsis-induced acute respiratory distress syndrome 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR	"circN4bp1 is up-regulated in sepsis-induced ARDS and promotes pro-inflammatory M1 macrophage polarization while inhibiting M2 polarization. Mechanistically it acts as a miR-138-5p sponge to increase EZH2 (with downstream STAT1/PPAR-gamma signaling changes), and its elevation is linked to increased m6A modification (METTL3-dependent). High circN4bp1 in PBMCs/monocytes associates with worse prognosis."	0.8739
35002727	Frontiers in pharmacology	2021	AhR Antagonist Promotes Differentiation of Papillary Thyroid Cancer via Regulating circSH2B3/miR-4640-5P/IGF2BP2 Axis.	hsa_circ_0006741	circSH2B3	hsa_circ_SH2B3	SH2B3	papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"circSH2B3 (hsa_circ_0006741), derived from SH2B3, promotes dedifferentiation of papillary thyroid cancer cells. It functions as a ceRNA by sponging hsa-miR-4640-5p to increase IGF2BP2, thereby reducing NIS expression and radioiodine uptake; AhR antagonists promote differentiation partly by inhibiting this circSH2B3/miR-4640-5p/IGF2BP2 axis."	0.7422
35003060	Frontiers in immunology	2021	Analyses of circRNA and mRNA Profiles in Vogt-Koyanagi-Harada Disease.	hsa_circ_0033144				Vogt_Koyanagi_Harada (VKH) disease 	MONDO:0018092	Vogt-Koyanagi-Harada disease	dysregulated	RT-qPCR; RNA-seq	hsa_circ_0033144 is differentially expressed in CD4+ T cells from active VKH patients versus controls (RNA-seq) and its dysregulation was validated by RT-qPCR. It was included in the study¡¯s circRNA profiling and candidate circRNA set used for downstream immune-related network analyses.	0.4032
35003060	Frontiers in immunology	2021	Analyses of circRNA and mRNA Profiles in Vogt-Koyanagi-Harada Disease.	hsa_circ_0000233				Vogt_Koyanagi_Harada (VKH) disease 	MONDO:0018092	Vogt-Koyanagi-Harada disease	dysregulated	RT-qPCR; RNA-seq	hsa_circ_0000233 is dysregulated in CD4+ T cells of VKH patients and was validated by RT-qPCR. It is included in a predicted immune-related circRNA-miRNA-mRNA ceRNA network that may contribute to VKH pathophysiology.	0.4032
35003060	Frontiers in immunology	2021	Analyses of circRNA and mRNA Profiles in Vogt-Koyanagi-Harada Disease.	hsa_circ_0000396				Vogt_Koyanagi_Harada (VKH) disease 	MONDO:0018092	Vogt-Koyanagi-Harada disease	dysregulated	RT-qPCR; RNA-seq	hsa_circ_0000396 is dysregulated in CD4+ T cells of VKH patients and was validated by RT-qPCR. It is part of a predicted immune-related ceRNA network potentially contributing to VKH disease.	0.4032
35003060	Frontiers in immunology	2021	Analyses of circRNA and mRNA Profiles in Vogt-Koyanagi-Harada Disease.	hsa_circ_0001924				Vogt_Koyanagi_Harada (VKH) disease 	MONDO:0018092	Vogt-Koyanagi-Harada disease	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0001924 is up-regulated in CD4+ T cells from active VKH patients and was validated by RT-qPCR. It was highlighted as a potential candidate marker gene and is implicated (by prediction) in immune/inflammation-related ceRNA regulation in VKH disease.	0.4032
35003060	Frontiers in immunology	2021	Analyses of circRNA and mRNA Profiles in Vogt-Koyanagi-Harada Disease.	hsa_circ_0001320				Vogt_Koyanagi_Harada (VKH) disease 	MONDO:0018092	Vogt-Koyanagi-Harada disease	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0001320 is up-regulated in CD4+ T cells from active VKH patients and was validated by RT-qPCR. It was highlighted as a potential candidate marker gene and is implicated (by prediction) in immune-related ceRNA regulation in VKH disease.	0.4032
35003259	Journal of oncology	2021	circITGA7 Acts as a miR-370-3p Sponge to Suppress the Proliferation of Prostate Cancer.		circITGA7	hsa_circ_ITGA7	ITGA7	Prostate cancer 	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; RNA-seq	"circITGA7 is down-regulated in prostate cancer tissues and cell lines and suppresses PCa cell proliferation by inducing G0/G1 arrest. It acts as a ceRNA by sponging miR-370-3p, thereby increasing the expression of P21CIP1; the anti-proliferative effect can be rescued by miR-370-3p overexpression."	0.7763
35003269	Stem cells international	2021	CircRNA FAT1 Regulates Osteoblastic Differentiation of Periodontal Ligament Stem Cells via miR-4781-3p/SMAD5 Pathway.		circRNA FAT1 	hsa_circ_FAT1	FAT1	periodontitis 	MONDO:0005076	periodontitis	unknown	RT-qPCR	"circFAT1 promotes osteogenic/osteoblastic differentiation of human PDLSCs and supports bone regeneration, mainly by acting as a miRNA sponge for miR-4781-3p to relieve repression of SMAD5. circFAT1 is predominantly localized in the cytoplasm and does not significantly affect PDLSC proliferation."	0.589
35004298	Frontiers in oncology	2021	METTL3 Is Suppressed by Circular RNA circMETTL3/miR-34c-3p Signaling and Limits the Tumor Growth and Metastasis in Triple Negative Breast Cancer.	hsa_circ_0101463	circMETTL3	hsa_circ_METTL3	METTL3	Triple negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"In TNBC, circMETTL3 is up-regulated and functions as a ceRNA by sponging miR-34c-3p, thereby increasing METTL3 expression. circMETTL3 over-expression suppresses TNBC cell proliferation, migration, invasion, and reduces tumor growth and lung metastasis in vivo."	0.528
35004326	Frontiers in oncology	2021	CircPIK3C2A Facilitates the Progression of Glioblastoma via Targeting miR-877-5p/FOXM1 Axis.	hsa_circ_0003577	circPIK3C2A	hsa_circ_PIK3C2A	PIK3C2A	glioblastoma 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR	"circPIK3C2A is up-regulated in glioblastoma cell lines and promotes proliferation, colony formation, migration and invasion. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-877-5p to increase FOXM1 expression, thereby enhancing GBM progression in vitro and in a nude-mouse xenograft model."	0.8324
35007184	"Cell cycle (Georgetown, Tex.)"	2022	The circ-PITX1 promotes non-small cell lung cancer development via the miR-30e-5p/ITGA6 axis.		circ-PITX1 	hsa_circ_PITX1	PITX1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ-PITX1 is up-regulated in NSCLC and promotes malignant phenotypes (proliferation, migration/invasion, EMT) while inhibiting apoptosis. It functions mainly as a ceRNA that sponges miR-30e-5p to relieve repression of ITGA6, thereby activating the ITGA6/PI3K/AKT pathway and correlating with poor patient survival."	0.798
35007362	Journal of clinical laboratory analysis	2022	Clinical values of expression signature of circCDR1AS and circHIAT1 in prostate cancer: Two circRNAs with regulatory function in androgen receptor (AR) and PI3K/AKT signaling pathways.	hsa_circ_0001946	circCDR1AS	hsa_circ_CDR1AS		prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	circCDR1AS is up-regulated in prostate cancer tissue compared with BPH and shows diagnostic potential to distinguish PCa from BPH (ROC AUC 0.848).	0.4187
35007362	Journal of clinical laboratory analysis	2022	Clinical values of expression signature of circCDR1AS and circHIAT1 in prostate cancer: Two circRNAs with regulatory function in androgen receptor (AR) and PI3K/AKT signaling pathways.	hsa_circ_0000096	circHIAT1 	hsa_circ_HIAT1	HIAT1	prostate cancer 	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR	circHIAT1 is down-regulated in prostate cancer tissue compared with BPH and shows diagnostic potential to distinguish PCa from BPH (ROC AUC 0.828).	0.4187
35008490	International journal of molecular sciences	2021	Circular RNA hsa_circ_0000190 Facilitates the Tumorigenesis and Immune Evasion by Upregulating the Expression of Soluble PD-L1 in Non-Small-Cell Lung Cancer.	hsa_circ_0000190	C190			non-small-cell lung carcinoma 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"In NSCLC, hsa_circ_0000190 (C190) promotes tumorigenic behaviors (proliferation, migration, invasion) and enhances tumor growth in xenografts. It elevates PD-L1 mRNA and increases secretion of soluble PD-L1 (sPD-L1), which may reduce anti-PD-L1 efficacy and T-cell activation, contributing to immune evasion and immunotherapy resistance."	0.6542
35012553	World journal of surgical oncology	2022	Hsa_circ_0020850 promotes the malignant behaviors of lung adenocarcinoma by regulating miR-326/BECN1 axis.	hsa_circ_0020850	circ_0020850	hsa_circ_NUP98	NUP98	lung adenocarcinoma	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	circ_0020850 is upregulated in lung adenocarcinoma and acts as an oncogenic circRNA. It promotes malignant phenotypes and tumor growth by sponging miR-326 to derepress BECN1 (circ_0020850/miR-326/BECN1 ceRNA axis). High circ_0020850 expression is associated with worse overall survival and more advanced clinicopathological features.	0.835
35013102	Cell death & disease	2022	Exosomal hsa_circ_0004658 derived from RBPJ overexpressed-macrophages inhibits hepatocellular carcinoma progression via miR-499b-5p/JAM3.	hsa_circ_0004658		hsa_circ_EMILIN2	EMILIN2	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"Exosomal hsa_circ_0004658 (derived from EMILIN2) suppresses HCC progression by inhibiting proliferation/migration and promoting apoptosis. It functions as a ceRNA that sponges miR-499b-5p, thereby de-repressing/upregulating JAM3 and reducing tumor growth in a xenograft model."	0.817
35022405	Cell death discovery	2022	CircRNA circTIAM1 promotes papillary thyroid cancer progression through the miR-646/HNRNPA1 signaling pathway.	hsa_circ_0061406	circTIAM1 	hsa_circ_TIAM1	TIAM1	papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"circTIAM1 (hsa_circ_0061406) is up-regulated in papillary thyroid cancer tissues and cell lines and promotes PTC cell proliferation and migration and supports tumor growth in xenografts. It mainly functions as a ceRNA by sponging miR-646, thereby relieving miR-646-mediated repression of HNRNPA1."	0.8802
35023214	Journal of clinical laboratory analysis	2022	CircRNA casein kinase 1 gamma 1 (circ-CSNK1G1) plays carcinogenic effects in thyroid cancer by acting as miR-149-5p sponge and relieving the suppression of miR-149-5p on mitogen-activated protein kinase 1 (MAPK1).	hsa_circ_0001955	circ-CSNK1G1 	hsa_circ_CSNK1G1	CSNK1G1	thyroid cancer	MONDO:0002108	thyroid cancer	up-regulated	RT-qPCR	"circ-CSNK1G1 is up-regulated in thyroid cancer tissues/cell lines and promotes malignant phenotypes (proliferation, survival, invasion) and xenograft tumor growth. Mechanistically, it acts as a ceRNA sponge for miR-149-5p, relieving miR-149-5p-mediated repression of MAPK1."	0.7489
35023295	ESC heart failure	2022	Circ_0001206 regulates miR-665/CRKL axis to alleviate hypoxia/reoxygenation-induced cardiomyocyte injury in myocardial infarction.	mmu_circ_0001206	circ_0001206	mmu_circ_CRKL	CRKL	myocardial infarction 	MONDO:0005068	myocardial infarction	down-regulated	RT-qPCR	"In myocardial infarction-related H/R cardiomyocyte injury models, circ_0001206 is down-regulated. Its overexpression protects cardiomyocytes by increasing viability/proliferation and reducing apoptosis, mainly via a ceRNA mechanism that sponges miR-665 to de-repress CRKL."	0.8093
35024241	Molecular therapy. Nucleic acids	2022	Promotion of tumor progression by exosome transmission of circular RNA circSKA3.		circSKA3	hsa_circ_SKA3	SKA3	breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circSKA3 is up-regulated in ascites exosomes from breast cancer patients and can be horizontally transferred between tumor cells via exosomes. Exosomal circSKA3 complexes with integrin beta1 and Tks5, enhancing invadopodia formation and promoting migration/invasion and tumor progression in vitro and in vivo."	0.774
35024242	Molecular therapy. Nucleic acids	2022	circRNA circMED27 acts as a prognostic factor and mediator to promote lenvatinib resistance of hepatocellular carcinoma.	hsa_circ_0006825	circMED27 	hsa_circ_MED27	MED27	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circMED27 is upregulated in HCC tissues and serum exosomes and is associated with worse prognosis. Functionally, circMED27 promotes lenvatinib resistance by acting as a ceRNA that sponges miR-655-3p, thereby increasing USP28 expression, with predominant cytoplasmic localization and validation in HCC cells and xenografts."	0.8062
35027503	Aging	2022	Circular RNA CUL2 regulates the development of colorectal cancer by modulating apoptosis and autophagy via miR-208a-3p/PPP6C.		circular RNA CUL2 	hsa_circ_CUL2	CUL2	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	"circCUL2 is down-regulated in colorectal cancer tissues and cell lines. Its overexpression suppresses CRC cell proliferation and tumor growth while inducing apoptosis and autophagy, acting through a ceRNA axis in which circCUL2 sponges miR-208a-3p to upregulate PPP6C."	0.7612
35027539	Cell death & disease	2022	Exosomal circRELL1 serves as a miR-637 sponge to modulate gastric cancer progression via regulating autophagy activation.	hsa_circ_0001400	circRELL1 	hsa_circ_RELL1	RELL1	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"circRELL1 (hsa_circ_0001400), derived from the RELL1 gene, is down-regulated in gastric cancer tissues and plasma exosomes and is associated with adverse clinicopathological features. Functionally, circRELL1 and exosomal circRELL1 suppress GC proliferation, migration/invasion, tumor growth and metastasis by acting as a ceRNA sponge for miR-637 to increase EPHB3 and modulate autophagy activity, supporting its potential as a circulating diagnostic/prognostic biomarker and therapeutic target."	0.8942
35029057	Journal of extracellular vesicles	2022	Extracellular vesicle-mediated delivery of circDYM alleviates CUS-induced depressive-like behaviours.		CircDYM 	mmu_circ_DYM	DYM	Major depressive disorder 	MONDO:0002009	major depressive disorder	down-regulated	RT-qPCR	"In a CUS mouse model of depression/MDD, circDYM is reduced in hippocampus, and systemic delivery of circDYM via RVG-engineered extracellular vesicles alleviates depressive-like behaviours. Mechanistically, circDYM binds the transcription factor TAF1, shifts TAF1 away from the nucleus, and downregulates TAF1 target genes (e.g., Trpm6 and Cyp39a1), thereby suppressing microglial activation and neuroinflammation and improving BBB/astrocyte-related pathology."	0.807
35029546	Endocrine connections	2022	Hsa_circ_0005729 enhances accuracy in diagnosing parathyroid carcinoma.	hsa_circ_0005729		hsa_circ_RNF138	RNF138	parathyroid carcinoma	MONDO:0012004	parathyroid gland carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005729 is up-regulated in parathyroid carcinoma tissue compared with parathyroid adenoma and can serve as a diagnostic biomarker. Combining hsa_circ_0005729 with serum calcium, creatinine, and ALP improves diagnostic performance (AUC up to 0.86). The study also assessed correlation with its host gene RNF138 mRNA, but did not elucidate a mechanism."	0.6238
35029546	Endocrine connections	2022	Hsa_circ_0005729 enhances accuracy in diagnosing parathyroid carcinoma.	hsa_circ_0027093				parathyroid carcinoma	MONDO:0012004	parathyroid gland carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0027093 is up-regulated in parathyroid carcinoma versus parathyroid adenoma and shows moderate diagnostic performance (AUC 0.69), which improves when combined with serum calcium, creatinine, and ALP (AUC 0.79). No downstream mechanism was investigated for this circRNA."	0.5958
35029546	Endocrine connections	2022	Hsa_circ_0005729 enhances accuracy in diagnosing parathyroid carcinoma.	hsa_circ_0005729		hsa_circ_RNF138	RNF138	parathyroid adenoma 	MONDO:0006890	parathyroid gland adenoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005729 is up-regulated in parathyroid carcinoma tissue compared with parathyroid adenoma and can serve as a diagnostic biomarker. Combining hsa_circ_0005729 with serum calcium, creatinine, and ALP improves diagnostic performance (AUC up to 0.86). The study also assessed correlation with its host gene RNF138 mRNA, but did not elucidate a mechanism."	0.6238
35029546	Endocrine connections	2022	Hsa_circ_0005729 enhances accuracy in diagnosing parathyroid carcinoma.	hsa_circ_0027093				parathyroid adenoma 	MONDO:0006890	parathyroid gland adenoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0027093 is up-regulated in parathyroid carcinoma versus parathyroid adenoma and shows moderate diagnostic performance (AUC 0.69), which improves when combined with serum calcium, creatinine, and ALP (AUC 0.79). No downstream mechanism was investigated for this circRNA."	0.5958
35029589	Aging	2022	Circular RNA circ_0000515 adsorbs miR-542-3p to accelerate bladder cancer progression via up-regulating ILK expression.	hsa_circ_0000515	circ_0000515 		RPPH1	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0000515 is up-regulated in bladder cancer tissues/cell lines and promotes proliferation/viability, migration, invasion and lung metastasis. Mechanistically, it sponges miR-542-3p to relieve repression of ILK, increasing ILK mRNA/protein and driving malignant phenotypes."	0.753
35030971	Bioengineered	2022	Circ_0019693 promotes osteogenic differentiation of bone marrow mesenchymal stem cell and enhances osteogenesis-coupled angiogenesis via regulating microRNA-942-5p-targeted purkinje cell protein 4 in the development of osteoporosis.	hsa_circ_0019693	circ_0019693 	hsa_circ_NOLC1	NOLC1	osteoporosis 	MONDO:0005298	osteoporosis	down-regulated	RT-qPCR	"circ_0019693 is down-regulated in serum and bone tissues of osteoporosis patients. Functionally, it promotes BMSC osteogenic differentiation and osteogenesis-coupled angiogenesis by sponging miR-942-5p, thereby relieving miR-942-5p repression of PCP4."	0.7944
35030979	Bioengineered	2022	Circular RNA hsa_circ_0032683 inhibits the progression of hepatocellular carcinoma by sponging microRNA-338-5p.	hsa_circ_0032683		hsa_circ_NEK9	NEK9	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"In hepatocellular carcinoma, hsa_circ_0032683 is down-regulated in tumors and HCC cell lines. It suppresses proliferation and promotes apoptosis by acting as a cytoplasmic ceRNA that sponges miR-338-5p, thereby increasing RTN4 expression; higher circRNA levels are associated with better patient survival."	0.8156
35030981	Bioengineered	2022	Circular RNA hsa_circ_0001658 regulates apoptosis and autophagy in gastric cancer through microRNA-182/Ras-related protein Rab-10 signaling axis.	hsa_circ_0001658	circ_0001658	hsa_circ_RAB10	RAB10	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001658 is up-regulated in gastric cancer and promotes GC cell viability and autophagy while inhibiting apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-182 to relieve repression of RAB10, forming the circ_0001658/miR-182/RAB10 axis."	0.657
35031054	Journal of experimental & clinical cancer research : CR	2022	Circ_0000658 knockdown inhibits epithelial-mesenchymal transition in bladder cancer via miR-498-induced HMGA2 downregulation.	hsa_circ_0000658	circular RNA_0000658 			bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"Circ_0000658 is up-regulated in bladder cancer tissues/cells and mainly localizes in the cytoplasm. It promotes EMT and malignant phenotypes by sponging miR-498 to upregulate HMGA2 (circ_0000658/miR-498/HMGA2 axis), and higher circ_0000658 correlates with worse OS/DFS."	0.8259
35031058	Molecular cancer	2022	EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3.	hsa_circ_0001460	circNEIL3	hsa_circ_NEIL3	NEIL3	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR; RNA-seq	"circNEIL3 (hsa_circ_0001460), derived from NEIL3, is up-regulated in glioma and increases with glioma grade. It promotes glioma proliferation/migration/invasion and tumor growth, and it drives macrophage infiltration and immunosuppressive polarization. Mechanistically, circNEIL3 is induced by EWSR1, binds and stabilizes IGF2BP3 by blocking HECTD4-mediated ubiquitination, and is packaged into exosomes via hnRNPA2B1 to act on TAMs and enhance YAP1 signaling."	0.9003
35032098	Journal of cellular and molecular medicine	2022	Screening differential circular RNA expression profiles reveals the regulatory role of circMARS in anti-tuberculosis drug-induced liver injury.	hsa_circ_0027252	circMARS	hsa_circ_MARS	MARS	anti-tuberculosis drug-induced liver injury 	MONDO:0005359	drug-induced liver injury	up-regulated	RT-qPCR; Microarray	"circMARS is up-regulated in ADLI patient serum and in anti-TB drug-treated hepatocytes. It functions as a miRNA sponge for miR-3157-5p/miR-6808-5p/miR-6874-3p to enhance KMT2C and EGFR levels, contributing to a compensatory repair response and showing potential diagnostic utility (AUC 0.80)."	0.824
35033075	Cancer cell international	2022	hsa_circ_0000231 Promotes colorectal cancer cell growth through upregulation of CCND2 by IGF2BP3/miR-375 dual pathway.	hsa_circ_0000231	circ_0000231	hsa_circ_ARHGAP12	ARHGAP12	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; Microarray	"hsa_circ_0000231 is up-regulated in colorectal cancer and promotes CRC cell proliferation and xenograft tumor growth. It upregulates CCND2 by sponging miR-375 (ceRNA mechanism) and by binding the RBP IGF2BP3 to stabilize/protect CCND2 from degradation, and high circRNA expression predicts poorer survival."	0.8429
35034536	Bioengineered	2022	The hsa_circRNA_102049 mediates the sorafenib sensitivity of hepatocellular carcinoma cells by regulating Reelin gene expression.	hsa_circ_0043278	hsa_circRNA_102049	hsa_circ_RELN		hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_102049 is down-regulated in sorafenib-resistant HCC cells. Its overexpression increases sorafenib sensitivity by sponging hsa-miR-214-3p to up-regulate RELN, influencing EMT markers and promoting apoptosis while inhibiting proliferation."	0.593
35034572	Bioengineered	2022	Circular RNA circ_0001955 promotes hepatocellular carcinoma tumorigenesis by up-regulating alkaline ceramidase 3 expression through microRNA-655-3p.	hsa_circ_0001955	circ_0001955	hsa_circ_CSNK1G1	CSNK1G1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0001955 is up-regulated in hepatocellular carcinoma and functions as an oncogenic circRNA. It promotes proliferation, migration/invasion, angiogenesis and EMT while inhibiting apoptosis, largely by sponging miR-655-3p to increase ACER3 expression; its knockdown suppresses tumor growth in xenografts."	0.8256
35035814	Journal of healthcare engineering	2022	circRNA LDLRAD3 Enhances the Malignant Behaviors of NSCLC Cells via the miR-20a-5p-SLC7A5 Axis Activating the mTORC1 Signaling Pathway.		circRNA LDLRAD3 	hsa_circ_LDLRAD3	LDLRAD3	non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circRNA LDLRAD3 is up-regulated in NSCLC tissues/cell lines and promotes NSCLC cell proliferation, migration, and invasion. Mechanistically, LDLRAD3 sponges miR-20a-5p to increase SLC7A5 expression and activates the mTORC1 signaling pathway, and high LDLRAD3 expression is associated with worse patient survival."	0.7396
35036070	Molecular therapy. Nucleic acids	2022	Analysis of the circRNA and T-UCR populations identifies convergent pathways in mouse and human models of Rett syndrome.		circSirt2	mmu_circ_Sirt2	Sirt2	Rett syndrome 	MONDO:0010726	Rett syndrome	dysregulated	RT-qPCR	"circSirt2 is dysregulated in MeCP2-deficient RTT mouse models and can post-transcriptionally increase SIRT2 protein levels without changing Sirt2 mRNA. This SIRT2 upregulation contributes to downstream changes in AMPAR subunits and GluR-1 acetylation, linking circSirt2 to cytoskeleton/AMPAR-related pathology in RTT."	0.6858
35036070	Molecular therapy. Nucleic acids	2022	Analysis of the circRNA and T-UCR populations identifies convergent pathways in mouse and human models of Rett syndrome.	hsa_circ_0050945	circ_0050945	hsa_circ_SIRT2	SIRT2	Rett syndrome 	MONDO:0010726	Rett syndrome	up-regulated	RT-qPCR	"hsa_circ_0050945 (a circSIRT2 species) is upregulated in MeCP2-KO human neural progenitor cells and localizes mainly to the cytoplasm. Its overexpression elevates SIRT2 protein without changing SIRT2 mRNA, contributing to SIRT2-dependent alterations of AMPAR subunit protein levels and GluR-1 acetylation in MeCP2-deficient cells."	0.4325
35036070	Molecular therapy. Nucleic acids	2022	Analysis of the circRNA and T-UCR populations identifies convergent pathways in mouse and human models of Rett syndrome.	hsa_circ_0050946	circ_0050946	hsa_circ_SIRT2	SIRT2	Rett syndrome 	MONDO:0010726	Rett syndrome	up-regulated	RT-qPCR; ISH	"hsa_circ_0050946 is a circSIRT2 transcript upregulated in MeCP2-KO human neural progenitor cells and detected by RNA ISH. It mainly accumulates in the cytoplasm and, like other circSIRT2 species, can elevate SIRT2 protein and contribute to SIRT2-dependent modulation of GluR protein levels and GluR-1 acetylation in MeCP2-deficient cells."	0.4325
35036070	Molecular therapy. Nucleic acids	2022	Analysis of the circRNA and T-UCR populations identifies convergent pathways in mouse and human models of Rett syndrome.	hsa_circ_0050948	circ_0050948	hsa_circ_SIRT2	SIRT2	Rett syndrome 	MONDO:0010726	Rett syndrome	up-regulated	RT-qPCR	"hsa_circ_0050948 is an upregulated circSIRT2 transcript in MeCP2-KO human neural progenitor cells. Along with other circSIRT2 species, it can post-transcriptionally increase SIRT2 protein and drive SIRT2-dependent changes in GluR protein levels/acetylation in MeCP2-deficient cells."	0.4062
35036070	Molecular therapy. Nucleic acids	2022	Analysis of the circRNA and T-UCR populations identifies convergent pathways in mouse and human models of Rett syndrome.	hsa_circ_0050951	circ_0050951	hsa_circ_SIRT2	SIRT2	Rett syndrome 	MONDO:0010726	Rett syndrome	up-regulated	RT-qPCR	"hsa_circ_0050951 is a circSIRT2 transcript upregulated in MeCP2-KO human neural progenitor cells. It is the most nuclear circSIRT2 species and is highly enriched in MeCP2 RIP, suggesting direct MeCP2 binding and possible nuclear retention; like other circSIRT2 RNAs it can elevate SIRT2 protein post-transcriptionally and influence downstream GluR regulation."	0.516
35036071	Molecular therapy. Nucleic acids	2022	Circular RNA circSmoc1-2 regulates vascular calcification by acting as a miR-874-3p sponge in vascular smooth muscle cells.		circSmoc1-2	rno_circ_Smoc1	Smoc1	vascular calcification 	MONDO:0005311	atherosclerosis	down-regulated	RT-qPCR; ISH; RNA-seq	"circSmoc1-2 is down-regulated during vascular calcification and primarily localizes to the cytoplasm. It inhibits calcification by sponging miR-874-3p and thereby relieving repression of the target gene Adam19, forming a circSmoc1-2/miR-874-3p/Adam19 ceRNA axis validated in VSMCs and mouse VC models."	0.8037
35036156	PeerJ	2021	Integrated analysis and the identification of a circRNA-miRNA-mRNA network in the progression of abdominal aortic aneurysm.	hsa_circ_0005073	circ_0005073 			abdominal aortic aneurysm 	MONDO:0005350	abdominal aortic aneurysm	down-regulated	Microarray	"circ_0005073 (circRNA_005073) is down-regulated in AAA tissue based on circRNA microarray reanalysis. It is predicted (via Circinteractome/Targetscan integration) to interact with miR-635/miR-527/miR-520h/miR-938/miR-518a-5p and thereby influence hub genes such as CCL2, SPP1 and UBA52 in a circRNA-miRNA-mRNA network."	0.1768
35036156	PeerJ	2021	Integrated analysis and the identification of a circRNA-miRNA-mRNA network in the progression of abdominal aortic aneurysm.	hsa_circ_0090069	circ_0090069 			abdominal aortic aneurysm 	MONDO:0005350	abdominal aortic aneurysm	down-regulated	Microarray	circ_0090069 (circRNA_090069) is down-regulated in AAA tissue based on circRNA microarray reanalysis. It is predicted to interact with miR-1206 and influence the hub gene RPS27A within a circRNA-miRNA-mRNA network; its biological role in AAA is not experimentally established in this study.	0.1768
35038914	mBio	2022	Human Papillomavirus Type 16 Circular RNA Is Barely Detectable for the Claimed Biological Activity.		circE7			cervical carcinogenesis 	MONDO:0005131	cervical carcinoma	unknown	RT-qPCR	This study confirms HPV16 circE7 is produced but is extremely low in CaSki (about 0.4 copies/cell) and primarily cytoplasmic. The authors conclude previously reported circE7-dependent effects on E7/proliferation were due to off-target suppression of linear E6*I/E6*II RNAs by circE7-targeting siRNAs rather than a genuine circE7 function.	0.6631
35039066	Molecular cancer	2022	CircNFIB inhibits tumor growth and metastasis through suppressing MEK1/ERK signaling in intrahepatic cholangiocarcinoma.	hsa_circ_0086376	circNFIB 	hsa_circ_NFIB	NFIB	intrahepatic cholangiocarcinoma 	MONDO:0003210	intrahepatic cholangiocarcinoma	down-regulated	RT-qPCR; RNA-seq	"circNFIB (hsa_circ_0086376; cNFIB) is down-regulated in metastatic ICC and functions as a tumor suppressor by inhibiting proliferation and metastasis. It localizes mainly in the cytoplasm and directly binds MEK1 to competitively disrupt MEK1_ERK2 interaction, leading to reduced ERK phosphorylation and suppression of ERK/MAPK signaling. Clinically, low cNFIB is associated with aggressive features and worse OS/RFS, and cNFIB overexpression enhances trametinib response and may delay resistance."	0.8996
35039758	Oxidative medicine and cellular longevity	2022	Circ_0004354 might compete with circ_0040039 to induce NPCs death and inflammatory response by targeting miR-345-3p-FAF1/TP73 axis in intervertebral disc degeneration.	hsa_circ_0040039	circ_0040039	hsa_circ_SNTB2	SNTB2	intervertebral disc degeneration 	MONDO:0011385	intervertebral disk degenerative disorder	up-regulated	RT-qPCR; Microarray	"circ_0040039 is up-regulated in IVDD NP tissues and promotes TNF-alpha-induced NPC PAoptosis, inflammatory response, growth inhibition, and ECM degradation. Mechanistically, it acts as a ceRNA by binding miR-345-3p (AGO2/RISC-associated) to increase FAF1 and TP73, with a stronger pro-apoptotic effect relative to circ_0004354."	0.8344
35039758	Oxidative medicine and cellular longevity	2022	Circ_0004354 might compete with circ_0040039 to induce NPCs death and inflammatory response by targeting miR-345-3p-FAF1/TP73 axis in intervertebral disc degeneration.	hsa_circ_0004354	circ_0004354	hsa_circ_SNTB2	SNTB2	intervertebral disc degeneration 	MONDO:0011385	intervertebral disk degenerative disorder	up-regulated	RT-qPCR; Microarray	"circ_0004354 is up-regulated in IVDD NP tissues and promotes TNF-alpha-induced NPC PAoptosis, inflammatory response, growth inhibition, and ECM degradation. It competitively binds miR-345-3p (AGO2/RISC-associated) to increase FAF1/TP73, showing a stronger tendency to drive pyroptosis-related features (e.g., GSDME cleavage and IL-1beta elevation) compared with circ_0040039."	0.8344
35039944	Cellular and molecular life sciences : CMLS	2022	Competing endogenous RNA network mediated by circ_3205 in SARS-CoV-2 infected cells.		circ_3205 	SARS-CoV-2_circ_N	N	COVID-19 	MONDO:0100096	COVID-19	up-regulated	RT-qPCR	"This study reports that the SARS-CoV-2-derived circ_3205 is detectable only in SARS-CoV-2-positive nasopharyngeal swab samples by RT-qPCR and is confirmed by Sanger sequencing of the back-splice junction. Bioinformatic predictions and expression correlations support a proposed ceRNA model in which circ_3205 sponges hsa-miR-298, contributing to increased KCNMB4 and PRKCE expression and potentially affecting immune response and blood coagulation processes during infection."	0.5466
35040370	Bioengineered	2022	CircRNA_0001795 sponges miRNA-339-5p to regulate yes-associated protein 1 expression and attenuate osteoporosis progression.	hsa_circ_0001795	circRNA_0001795 	hsa_circ_SLC20A2	SLC20A2	Osteoporosis 	MONDO:0005298	osteoporosis	down-regulated	RT-qPCR	"circ_0001795 is down-regulated in osteoporosis bone marrow samples. Functionally, circ_0001795 promotes osteogenic differentiation of hBMSCs by sponging miR-339-5p and relieving miR-339-5p-mediated repression of YAP1."	0.8144
35042525	Molecular cancer	2022	CircMET promotes tumor proliferation by enhancing CDKN2A mRNA decay and upregulating SMAD3.	hsa_circ_0082002	CircMET	hsa_circ_MET	MET	tumor	MONDO:0004992	cancer	up-regulated	RT-qPCR; ISH	"In NONO-TFE3 tRCC, circMET is up-regulated and promotes tumor cell proliferation and cell-cycle progression. Mechanistically, m6A-modified circMET is exported to the cytoplasm via YTHDC1, directly binds CDKN2A mRNA to recruit YTHDF2 and accelerate CDKN2A mRNA decay, and acts as a ceRNA sponging miR-1197 to upregulate SMAD3."	0.8165
35044104	Thoracic cancer	2022	Circ_0007580 knockdown strengthens the radiosensitivity of non-small cell lung cancer via the miR-598-dependent regulation of THBS2.	hsa_circ_0007580	circ_0007580	hsa_circ_PRKCA	PRKCA	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0007580 is up-regulated in NSCLC (especially radioresistant tissues) and promotes radioresistance. Its knockdown enhances radiosensitivity by inhibiting proliferation and promoting apoptosis, mainly via sponging miR-598 to upregulate THBS2 (circ_0007580/miR-598/THBS2 axis)."	0.7412
35045295	Cell reports	2022	A bidirectional competitive interaction between circHomer1 and Homer1b within the orbitofrontal cortex regulates reversal learning.			hsa_circ_HOMER1	HOMER1	bipolar disorder 	MONDO:0004985	bipolar disorder	down-regulated	RT-qPCR	"circHomer1 (from HOMER1) is down-regulated in BD (OFC and peripheral cells) and in SCZ (DLPFC). Mechanistically, it directly binds Homer1b mRNA (3¡ä UTR) and mutually inhibits synaptic expression/localization with Homer1b in mouse OFC, affecting reversal learning; EIF4A3 binds circHomer1 and promotes its biogenesis."	0.7884
35045295	Cell reports	2022	A bidirectional competitive interaction between circHomer1 and Homer1b within the orbitofrontal cortex regulates reversal learning.		circHomer1 	mmu_circ_Homer1 	Homer1 	bipolar disorder 	MONDO:0004985	bipolar disorder	down-regulated	RT-qPCR	"circHomer1 (from HOMER1) is down-regulated in BD (OFC and peripheral cells) and in SCZ (DLPFC). Mechanistically, it directly binds Homer1b mRNA (3¡ä UTR) and mutually inhibits synaptic expression/localization with Homer1b in mouse OFC, affecting reversal learning; EIF4A3 binds circHomer1 and promotes its biogenesis."	0.7884
35045883	Molecular cancer	2022	circFARP1 enables cancer-associated fibroblasts to promote gemcitabine resistance in pancreatic cancer via the LIF/STAT3 axis.	hsa_circ_0002557	circFARP1	hsa_circ_FARP1	FARP1	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circFARP1 is a CAF-enriched circRNA upregulated in gemcitabine-resistant PDAC and associated with worse PFS. It promotes GEM resistance by increasing CAF-derived LIF (both expression and secretion), activating STAT3 signaling in tumor cells. Mechanistically, it sponges miR-660-3p to relieve repression of LIF and binds CAV1 to inhibit ZNRF1-mediated ubiquitination/degradation of CAV1, enhancing LIF secretion."	0.892
35048477	Cancer science	2022	Circ_0002623 promotes bladder cancer progression by regulating the miR-1276/SMAD2 axis.	hsa_circ_0002623	circ_0002623	hsa_circ_VANGL1	VANGL1	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0002623 is upregulated in bladder cancer and acts as an oncogenic circRNA. It mainly localizes to the cytoplasm and promotes proliferation, migration, cell-cycle progression and in vivo tumor growth/metastasis by sponging miR-1276 to increase SMAD2, thereby enhancing TGF-beta and Wnt-related signaling (e.g., WNT1). High circ_0002623 expression correlates with lymph node metastasis and poorer overall survival."	0.84
35048790	Bioengineered	2022	Circular RNA SOX5 promotes the proliferation and inhibits the apoptosis of the hepatocellular carcinoma cells by targeting miR-502-5p/synoviolin 1 axis.		circ-SOX5 	hsa_circ_SOX5	SOX5	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	circ-SOX5 is up-regulated in HCC tissues/serum and HCC cell lines. It promotes HCC cell proliferation/viability and migration/invasion while inhibiting apoptosis via a ceRNA mechanism by sponging miR-502-5p and upregulating SYVN1.	0.8122
35051313	Clinical and translational medicine	2022	circKCNN2 suppresses the recurrence of hepatocellular carcinoma at least partially via regulating miR-520c-3p/methyl-DNA-binding domain protein 2 axis.	hsa_circ_0127664	circKCNN2	hsa_circ_KCNN2	KCNN2	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"circKCNN2 is downregulated in HCC and acts as a tumor-suppressive circRNA associated with lower recurrence risk and better survival. Mechanistically, it is repressed by NFYA and suppresses HCC progression by sponging miR-520c-3p to modulate MBD2 and downstream FGFR4, influencing lenvatinib response."	0.8913
35052380	Genes	2021	Circular RNA circYPEL2: A Novel Biomarker in Cervical Cancer.	hsa_circ_0005600	circYPEL2	hsa_circ_YPEL2	YPEL2	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; RNA-seq	"circYPEL2 (hsa_circ_0005600), derived from YPEL2 exon 2, is up-regulated in cervical cancer and mainly localized in the cytoplasm. Functional assays show circYPEL2 promotes cervical cancer cell proliferation, migration, and invasion; knockdown alters downstream gene expression with enrichment in EMT and KRAS signaling-related programs."	0.685
35054834	International journal of molecular sciences	2022	CircRNAs as Potential Blood Biomarkers and Key Elements in Regulatory Networks in Gastric Cancer.	hsa_circ_0000211	circSFMBT2	hsa_circ_SFMBT2	SFMBT2	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000211 is up-regulated in gastric cancer in both gastric tissue and peripheral blood by RT-qPCR, supporting its potential as a minimally invasive diagnostic biomarker. The study also predicts its involvement in circRNA-miRNA-mRNA and circRNA-RBP regulatory networks with cancer-related pathway enrichment."	0.5047
35054834	International journal of molecular sciences	2022	CircRNAs as Potential Blood Biomarkers and Key Elements in Regulatory Networks in Gastric Cancer.	hsa_circ_0000284	circHIPK3	hsa_circ_HIPK3	HIPK3	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000284 (circHIPK3) is up-regulated in gastric cancer in both gastric tissue and peripheral blood by RT-qPCR, suggesting diagnostic biomarker potential. The study additionally analyzes predicted circHIPK3-associated miRNA/mRNA and RBP interaction networks and enriches cancer-related pathways."	0.5267
35054834	International journal of molecular sciences	2022	CircRNAs as Potential Blood Biomarkers and Key Elements in Regulatory Networks in Gastric Cancer.	hsa_circ_0000524	circRBM23	hsa_circ_RBM23	RBM23	gastric cancer 	MONDO:0001056	gastric cancer	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0000524 shows opposite expression changes depending on sample type: it is down-regulated in gastric cancer tissue (and adjacent tissue) versus non-cancer tissue, but up-regulated in peripheral blood of gastric cancer patients versus controls. The study evaluates it as a potential minimally invasive diagnostic marker and includes predicted miRNA/mRNA and RBP interaction/pathway enrichment analyses."	0.5047
35054834	International journal of molecular sciences	2022	CircRNAs as Potential Blood Biomarkers and Key Elements in Regulatory Networks in Gastric Cancer.	hsa_circ_0001136	circASXL1	hsa_circ_ASXL1	ASXL1	gastric cancer 	MONDO:0001056	gastric cancer	unknown	RT-qPCR; RNA-seq	"hsa_circ_0001136 is significantly up-regulated in peripheral blood from gastric cancer patients, but shows only a non-significant upregulation trend in gastric tissue in this validation cohort. It is evaluated as a less invasive biomarker candidate and included in predicted miRNA/mRNA and RBP interaction network/pathway enrichment analyses."	0.5047
35054834	International journal of molecular sciences	2022	CircRNAs as Potential Blood Biomarkers and Key Elements in Regulatory Networks in Gastric Cancer.	hsa_circ_0004771	circNRIP1	hsa_circ_NRIP1	NRIP1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0004771 (circNRIP1) is up-regulated in gastric cancer in both gastric tissue and peripheral blood by RT-qPCR and is proposed as a minimally invasive diagnostic biomarker candidate. The paper notes QKI as an RBP related to its biogenesis and analyzes predicted interaction networks and pathway enrichment relevant to gastric carcinogenesis.	0.5047
35057034	Pharmaceutics	2022	Impact of circ-0000221 in the Pathogenesis of Hepatocellular via Modulation of miR-661-PTPN11 mRNA Axis.	hsa_circ_0000221		hsa_circ_VIM	VIM	Hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"In HCC, hsa-circ-0000221 (VIM-derived) is down-regulated in patient serum and functions as a tumor suppressor in vitro. Its overexpression in HepG2/SNU449 inhibits miR-661 and increases PTPN11 mRNA, reducing viability/colony formation and inducing G1 accumulation and caspase/mitochondria-associated apoptosis."	0.6536
35058790	Frontiers in physiology	2021	circHIPK3 Exacerbates Folic Acid-Induced Renal Tubulointerstitial Fibrosis by Sponging miR-30a.		circHIPK3	hsa_circ_HIPK3	HIPK3	renal tubulointerstitial fibrosis 	MONDO:0001085	interstitial nephritis	up-regulated	RT-qPCR; ISH	"circHIPK3 is up-regulated in folic acid-induced renal tubulointerstitial fibrosis and in human cTIN fibrotic kidney tissue. It localizes mainly to the cytoplasm and exacerbates fibrosis by sponging miR-30a, thereby increasing TGF-beta1 and downstream profibrotic factors (FN, COL1) in a feed-forward loop."	0.6046
35059468	Journal of immunology research	2022	Circular RNA circFGFR1 Functions as an Oncogene in Glioblastoma Cells through Sponging to hsa-miR-224-5p.	hsa_circ_0084003	circFGFR1 	hsa_circ_FGFR1	FGFR1	glioblastoma 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR	"circFGFR1 is upregulated in glioma/GBM cell models and promotes proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, it sponges hsa-miR-224-5p to relieve repression of CXCR4, thereby increasing CXCR4 expression and driving oncogenic phenotypes."	0.7703
35060189	Journal of clinical laboratory analysis	2022	Hsa_circRNA_0001971 contributes to oral squamous cell carcinoma progression via miR-186-5p/Fibronectin type III domain containing 3B axis.	hsa_circ_0001971	circ_0001971 			oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circRNA_0001971 is up-regulated in OSCC tissues and cell lines and functions as an oncogenic circRNA by promoting proliferation, migration, and invasion. Mechanistically, it acts as a ceRNA sponge for miR-186-5p, leading to increased FNDC3B expression in OSCC cells."	0.6996
35060203	Journal of clinical laboratory analysis	2022	Hsa_circ_0050102 regulates the pancreatic cancer development via miR-218-5p/PPME1 axis.	hsa_circ_0050102	Circ_0050102	hsa_circ_PGPEP1	PGPEP1	pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"hsa_circ_0050102 is up-regulated in pancreatic cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes pancreatic cancer cell proliferation, migration/invasion and angiogenesis and inhibits apoptosis by sponging miR-218-5p to increase PPME1 expression, and its knockdown suppresses xenograft tumor growth."	0.8039
32385717	Molecular and cellular biochemistry	2020	CircularRNA-9119 promotes the proliferation of cervical cancer cells by sponging miR-126/MDM4.		circ9119			cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ9119 is up-regulated in cervical cancer tissues and cell lines and acts as an oncogenic circRNA. It promotes proliferation and tumor growth while inhibiting apoptosis by sponging miR-126 and increasing MDM4 expression, with the circ9119/miR-126/MDM4 axis implicated in CC occurrence and progression."	0.6536
32387133	Biological psychiatry	2020	N6-Methyladenosine Modification of Fatty Acid Amide Hydrolase Messenger RNA in Circular RNA STAG1-Regulated Astrocyte Dysfunction and Depressive-like Behaviors.			hsa_circ_STAG1	STAG1	major depressive disorder 	MONDO:0002009	major depressive disorder	down-regulated	RT-qPCR; RNA-seq	"circSTAG1 is down-regulated in the hippocampus and blood of CUS mice and in peripheral blood of patients with MDD. Functionally, circSTAG1 overexpression attenuates astrocyte dysfunction, astrocyte loss, and depressive-like behaviors. Mechanistically, circSTAG1 captures ALKBH5 in the cytoplasm, limits ALKBH5 nuclear translocation, increases m6A methylation and degradation of FAAH mRNA, and may serve as a therapeutic target and blood-based biomarker candidate for MDD."	0.8814
32387133	Biological psychiatry	2020	N6-Methyladenosine Modification of Fatty Acid Amide Hydrolase Messenger RNA in Circular RNA STAG1-Regulated Astrocyte Dysfunction and Depressive-like Behaviors.	mm9_circ_0015149		mmu_circ_STAG1; 	STAG1	major depressive disorder 	MONDO:0002009	major depressive disorder	down-regulated	RT-qPCR; RNA-seq	"circSTAG1 is down-regulated in the hippocampus and blood of CUS mice and in peripheral blood of patients with MDD. Functionally, circSTAG1 overexpression attenuates astrocyte dysfunction, astrocyte loss, and depressive-like behaviors. Mechanistically, circSTAG1 captures ALKBH5 in the cytoplasm, limits ALKBH5 nuclear translocation, increases m6A methylation and degradation of FAAH mRNA, and may serve as a therapeutic target and blood-based biomarker candidate for MDD."	0.8814
32388272	Environment international	2020	Circular RNA 406961 interacts with ILF2 to regulate PM2.5-induced inflammatory responses in human bronchial epithelial cells via activation of STAT3/JNK pathways.		circ_406961	hsa_circ_PTPN12	PTPN12	PM2.5-induced inflammatory response 	MONDO:0043905	pneumonitis	down-regulated	RT-qPCR; Microarray	"In PM2.5-exposed human bronchial epithelial BEAS-2B cells, circ_406961 is down-regulated and functions as an inhibitor of cytotoxic and inflammatory responses. Mechanistically, circ_406961 localizes mainly in the nucleus, interacts with ILF2 protein, and suppresses PM2.5-induced activation of STAT3/JNK pathways, reducing IL-6 and IL-8 inflammatory factor release."	0.7595
32388910	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2020	Oncogenic circular RNA Hsa-circ-000684 interacts with microRNA-186 to upregulate ZEB1 in gastric cancer.	hsa_circ_0001013	hsa-circ-000684			gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Northern Blot; Microarray	"hsa-circ-000684 is upregulated in gastric cancer tissues and cell lines. It promotes GC proliferation, migration, invasion, angiogenesis/tube formation, and xenograft growth by acting as a miR-186 sponge and increasing ZEB1 expression. Its expression correlates with lymph node metastasis and TNM stage, suggesting biological and potential therapeutic relevance."	0.866
32389802	Brain research bulletin	2020	Comprehensive circular RNA profiling reveals that hsa_circ_0001368 is involved in growth hormone-secreting pituitary adenoma development.	hsa_circ_0001368		hsa_circ_KLHL24	KLHL24	growth hormone-secreting pituitary adenoma 	MONDO:0006238	growth hormone-producing pituitary gland adenoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001368 is specifically up-regulated in GHPA and correlates with invasiveness, serum GH level, tumor size, Knosp grade, and Pit-1 expression. Knockdown suppresses proliferation, migration, invasion, GH secretion/expression, and increases apoptosis in GHPA primary cultured cells, suggesting an oncogenic and clinically relevant role."	0.7519
32389802	Brain research bulletin	2020	Comprehensive circular RNA profiling reveals that hsa_circ_0001368 is involved in growth hormone-secreting pituitary adenoma development.	hsa_circ_0023984				growth hormone-secreting pituitary adenoma 	MONDO:0006238	growth hormone-producing pituitary gland adenoma	up-regulated	RT-qPCR; Microarray	hsa_circ_0023984 was up-regulated in GHPA by microarray and confirmed by qRT-PCR. It was incorporated into a predicted circRNA-miRNA-target gene network and may indirectly regulate GHPA development through miRNA-mediated effects on pituitary tumor-related genes.	0.4032
32389802	Brain research bulletin	2020	Comprehensive circular RNA profiling reveals that hsa_circ_0001368 is involved in growth hormone-secreting pituitary adenoma development.	hsa_circ_0009145				growth hormone-secreting pituitary adenoma 	MONDO:0006238	growth hormone-producing pituitary gland adenoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0009145 was identified among the top up-regulated circRNAs in GHPA and its up-regulation was confirmed by qRT-PCR. It was included in the predicted circRNA-miRNA-target gene network, but no circRNA-specific mechanistic or functional validation was reported."	0.4032
32389802	Brain research bulletin	2020	Comprehensive circular RNA profiling reveals that hsa_circ_0001368 is involved in growth hormone-secreting pituitary adenoma development.	hsa_circ_0008336				growth hormone-secreting pituitary adenoma 	MONDO:0006238	growth hormone-producing pituitary gland adenoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0008336 was identified among the top up-regulated circRNAs in GHPA and its up-regulation was confirmed by qRT-PCR. It was included in the predicted circRNA-miRNA-target gene network, but no circRNA-specific mechanistic or functional validation was reported."	0.4032
32390598	Cancer biomarkers : section A of Disease markers	2020	Circular RNA circ_0000337 contributes to osteosarcoma via the miR-4458/BACH1 pathway.	hsa_circ_0000337	circ_0000337 	hsa_circ_PPFIA1	PPFIA1	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ_0000337 is upregulated in osteosarcoma cell lines and promotes OS cell proliferation and migration while suppressing apoptosis. Mechanistically, it functions as a miR-4458 sponge to increase BACH1 expression, forming a circ_0000337/miR-4458/BACH1 regulatory pathway that facilitates OS progression and may provide a therapeutic target."	0.6528
32391718	Cancer biotherapy & radiopharmaceuticals	2021	Circ_0000526 Blocks the Progression of Breast Cancer by Sponging miR-492.	hsa_circ_0000526				breast cancer	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	"circ_0000526 is down-regulated in breast cancer tissues and cell lines and acts as a tumor suppressor. Mechanistically, it sponges miR-492 and thereby indirectly increases SOCS2 expression, suppressing breast cancer cell proliferation, migration, invasion, and metastasis. Low circ_0000526 expression is associated with unfavorable clinicopathological features, including lymph node metastasis."	0.6521
32392088	Circulation research	2020	"The Tumor-Suppressive Human Circular RNA CircITCH Sponges miR-330-5p to Ameliorate Doxorubicin-Induced Cardiotoxicity Through Upregulating SIRT6, Survivin, and SERCA2a."	hsa_circ_0001141		hsa_circ_ITCH	ITCH	doxorubicin-induced cardiotoxicity 	MONDO:0023006	doxorubicin induced cardiomyopathy	down-regulated	RT-qPCR; Northern Blot; ISH; RNA-seq	"CircITCH (hsa_circ_0001141), an ITCH-derived human circRNA, is downregulated in DOX-induced cardiotoxicity. It protects cardiomyocytes and mouse hearts from DOXIC by sponging miR-330-5p and relieving repression of SIRT6, BIRC5/Survivin, and ATP2A2/SERCA2a, thereby reducing oxidative stress, DNA damage and cell death while improving contractile function and calcium handling."	0.8581
32407167	Cancer biotherapy & radiopharmaceuticals	2021	CircSMARCA5 Facilitates the Progression of Prostate Cancer Through miR-432/PDCD10 Axis.			hsa_circ_SMARCA5	SMARCA5	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circSMARCA5 is upregulated in prostate cancer tissues and cells and mainly localizes to the cytoplasm. It promotes proliferation, migration, invasion, EMT, glycolysis, and xenograft tumor growth by sponging miR-432 to increase PDCD10 expression. The circSMARCA5/miR-432/PDCD10 axis is proposed as a potential therapeutic target for PCa."	0.8111
32409849	Journal of molecular histology	2020	Comprehensive profiling of circRNAs and the tumor suppressor function of circHIPK3 in clear cell renal carcinoma.	hsa_circ_0000284	circHIPK3	hsa_circ_HIPK3	HIPK3	clear cell renal carcinoma 	MONDO:0005005	clear cell renal carcinoma	down-regulated	RT-qPCR; RNA-seq	"circHIPK3 is downregulated in CCRCC tissues and cell lines. Its overexpression suppresses CCRCC migration, invasion, and proliferation in vitro and inhibits xenograft tumor growth in vivo, suggesting a tumor-suppressive role. Mechanistically, circHIPK3 may target miR-637 in CCRCC cells."	0.7591
32409849	Journal of molecular histology	2020	Comprehensive profiling of circRNAs and the tumor suppressor function of circHIPK3 in clear cell renal carcinoma.	hsa_circ_0003520				clear cell renal carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0003520 was identified by circRNA-seq as dysregulated in CCRCC and validated by qRT-PCR as upregulated in CCRCC tissues compared with matched adjacent normal renal tissues. No functional or mechanistic experiments were reported for this circRNA.	0.429
32409849	Journal of molecular histology	2020	Comprehensive profiling of circRNAs and the tumor suppressor function of circHIPK3 in clear cell renal carcinoma.	hsa_circ_0046677				clear cell renal carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0046677 was identified by circRNA-seq as dysregulated in CCRCC and validated by qRT-PCR as upregulated in CCRCC tissues compared with matched adjacent normal renal tissues. No functional or mechanistic experiments were reported for this circRNA.	0.429
32409849	Journal of molecular histology	2020	Comprehensive profiling of circRNAs and the tumor suppressor function of circHIPK3 in clear cell renal carcinoma.		circCCRCC			clear cell renal carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR; RNA-seq	"circCCRCC was newly identified in CCRCC tissues and validated by qRT-PCR as upregulated in CCRCC tissues compared with matched adjacent normal renal tissues. The authors suggested it may have an oncogenic role, but functional validation was not performed in this study."	0.429
32420810	"Cell cycle (Georgetown, Tex.)"	2020	Circular RNA ABCB10 promotes non-small cell lung cancer progression by increasing E2F5 expression through sponging miR-584-5p.	hsa_circ_0008717		hsa_circ_ABCB10	ABCB10	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"CircABCB10/hsa_circ_0008717 is up-regulated in NSCLC tissues and cell lines, and high expression predicts poorer survival. Functionally, circABCB10 promotes NSCLC proliferation, colony formation, migration, invasion, metastasis and xenograft tumor growth. Mechanistically, it acts as a miR-584-5p sponge to increase E2F5 expression, forming a circABCB10/miR-584-5p/E2F5 regulatory axis."	0.7369
32423803	Biochemical and biophysical research communications	2020	Circular RNA hsa_circ_0008285 inhibits colorectal cancer cell proliferation and migration via the miR-382-5p/PTEN axis.	hsa_circ_0008285		hsa_circ_CDYL	CDYL	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0008285/circ_0008285 is downregulated in CRC tissues and cell lines and acts as a tumor-suppressive circRNA. It inhibits CRC cell proliferation and migration by sponging miR-382-5p, upregulating PTEN, and suppressing PI3K/AKT signaling; lower expression correlates with larger tumor size, lymphatic metastasis, and advanced TNM stage."	0.802
32423804	Biochemical and biophysical research communications	2020	Matrine reduces the secretion of exosomal circSLC7A6 from cancer-associated fibroblast to inhibit tumorigenesis of colorectal cancer by regulating CXCR5.	hsa_circ_0039943		hsa_circ_SLC7A6	SLC7A6	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"This study identifies CAF-derived exosomal circSLC7A6 as an oncogenic circRNA in colorectal cancer. circSLC7A6 is upregulated in CRC tissues and cell lines, promotes proliferation, invasion and tumor growth, suppresses apoptosis, and acts through positive regulation of CXCR5. Matrine inhibits CRC tumorigenesis partly by reducing exosomal circSLC7A6 secretion from CAFs."	0.7408
32423867	Cellular signalling	2020	Identification and characterization of tumorigenic circular RNAs in cervical cancer.	hsa_circ_0001495				cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RNA-seq	"hsa_circ_0001495 was identified as an up-regulated circRNA in cervical cancer. Bioinformatics analyses predicted that it interacts with the RBP ESRP2 and functions as a miRNA sponge competing with TBL1XR1, thereby promoting epithelial cell proliferation and NOTCH signaling in CC tumorigenesis."	0.1768
32423867	Cellular signalling	2020	Identification and characterization of tumorigenic circular RNAs in cervical cancer.	hsa_circ_0080414				cervical cancer 	MONDO:0002974	cervical cancer	down-regulated	RNA-seq	"hsa_circ_0080414 was identified as a down-regulated tumorigenic circRNA in cervical cancer. It was predicted to act through a ceRNA network regulating downstream genes such as ESR1 and FOXL2, and its downregulation may impair normal cervix-related functions and contribute to unfavorable prognosis."	0.348
32423867	Cellular signalling	2020	Identification and characterization of tumorigenic circular RNAs in cervical cancer.			hsa_circ_TGFBR2	TGFBR2	cervical cancer 	MONDO:0002974	cervical cancer	dysregulated	RNA-seq	"circTGFBR2 was identified as a dysregulated circRNA in cervical cancer with an inverse expression relationship to its host gene TGFBR2. The study predicted that circTGFBR2 may inhibit TGFBR2 expression, possibly by competing with linear RNA during splicing."	0.1768
32423867	Cellular signalling	2020	Identification and characterization of tumorigenic circular RNAs in cervical cancer.			hsa_circ_KDM4C	KDM4C	cervical cancer 	MONDO:0002974	cervical cancer	dysregulated	RNA-seq	"circKDM4C was identified as a dysregulated circRNA in cervical cancer with an inverse expression relationship to its host gene KDM4C. The study predicted that circKDM4C may inhibit KDM4C expression, possibly by competing with linear RNA during splicing."	0.1768
32423991	Molecular and cellular biology	2020	Circular RNA CDR1as Exerts Oncogenic Properties Partially through Regulating MicroRNA 641 in Cholangiocarcinoma.		CDR1as / ciRS-7			cholangiocarcinoma 	MONDO:0019087	cholangiocarcinoma	up-regulated	RT-qPCR	"CDR1as is up-regulated in human cholangiocarcinoma cell lines and acts as an oncogenic circRNA. It promotes proliferation, migration, invasion, AKT3/mTOR pathway activation, and xenograft tumor growth, at least partly by binding miR-641, promoting miR-641 degradation, and increasing AKT3 and mTOR transcript stability/expression. The study suggests the CDR1as/miR-641 axis as a potential therapeutic target in CCA."	0.7794
32428698	Gene	2020	Circular RNA circ_0001368 inhibited growth and invasion in renal cell carcinoma by sponging miR-492 and targeting LATS2.	hsa_circ_0001368	circ_0001368			renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	down-regulated	RT-qPCR	"circ_0001368 is downregulated in renal cell carcinoma and functions as a tumor suppressor. It inhibits RCC cell growth, proliferation, migration and invasion by sponging miR-492 and relieving miR-492-mediated repression of LATS2. Clinically, higher circ_0001368 expression is associated with better overall survival and may have biomarker or therapeutic relevance."	0.713
32441115	Circulation	2020	Extracellular Vesicle-Mediated Delivery of Circular RNA SCMH1 Promotes Functional Recovery in Rodent and Nonhuman Primate Ischemic Stroke Models.			hsa_circ_SCMH1	SCMH1	ischemic stroke 	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR; Microarray	"circSCMH1 is decreased in plasma from AIS patients and in mouse stroke models, and its level has diagnostic and outcome-predictive value. Therapeutic delivery of circSCMH1 via engineered RVG-EVs improves functional recovery after ischemic stroke in rodents and nonhuman primates by promoting neuronal plasticity and suppressing glial activation and peripheral immune cell infiltration. Mechanistically, circSCMH1 binds MeCP2 and releases repression of MeCP2 downstream target genes such as Mobp, Igfbp3, Fxyd1, and Prodh."	0.8508
32445866	Free radical biology & medicine	2020	The circular RNA TLK1 exacerbates myocardial ischemia/reperfusion injury via targeting miR-214/RIPK1 through TNF signaling pathway.		mm9_circ_009932	mmu_circ_TLK1	TLK1	myocardial ischemia	MONDO:0024644	myocardial ischemia	up-regulated	RT-qPCR	"circTLK1 is up-regulated in a mouse myocardial ischemia/reperfusion injury model and aggravates myocardial injury. Mechanistically, circTLK1 sponges miR-214, thereby relieving repression of RIPK1 and activating RIPK1-mediated TNF signaling, which promotes cardiomyocyte apoptosis and tissue damage. Silencing circTLK1 protects cardiac tissue and may represent a biomarker or therapeutic strategy for myocardial IRI."	0.6562
32445925	Gene	2020	CircFOXO3 functions as a molecular sponge for miR-143-3p to promote the progression of gastric carcinoma via upregulating USP44.	hsa_circ_0006404	CircFOXO3 	hsa_circ_FOXO3	FOXO3	gastric carcinoma 	MONDO:0004950	gastric carcinoma	up-regulated	RT-qPCR	"CircFOXO3 is reported to be upregulated in gastric carcinoma models and to promote malignant phenotypes, including proliferation, migration, and xenograft tumor growth. Mechanistically, circFOXO3 acts as a sponge/scaffold for miR-143-3p, relieving miR-143-3p-mediated repression of USP44 and thereby enhancing the miR-143-3p-USP44 axis in GC progression."	0.6562
32446265	The FEBS journal	2021	Hsa_circ_0000515 is a novel circular RNA implicated in the development of breast cancer through its regulation of the microRNA-296-5p/CXCL10 axis.	hsa_circ_0000515				breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Northern Blot; ISH; Microarray	"Hsa_circ_0000515 is up-regulated in breast cancer tissues and cell lines, and high expression is associated with poor prognosis. Mechanistically, cytoplasmic hsa_circ_0000515 binds miR-296-5p and relieves miR-296-5p-mediated repression of CXCL10, promoting breast cancer cell proliferation, invasion, angiogenesis, inflammation, cell-cycle progression, and xenograft tumor growth."	0.8537
32446265	The FEBS journal	2021	Hsa_circ_0000515 is a novel circular RNA implicated in the development of breast cancer through its regulation of the microRNA-296-5p/CXCL10 axis.	hsa_circ_0001013				breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Northern Blot; ISH; Microarray	"Hsa_circ_0000515 is up-regulated in breast cancer tissues and cell lines, and high expression is associated with poor prognosis. Mechanistically, cytoplasmic hsa_circ_0000515 binds miR-296-5p and relieves miR-296-5p-mediated repression of CXCL10, promoting breast cancer cell proliferation, invasion, angiogenesis, inflammation, cell-cycle progression, and xenograft tumor growth."	0.8537
32449799	Cell biology international	2020	Circular RNA hsa_circ_0085131 is involved in cisplatin-resistance of non-small-cell lung cancer cells by regulating autophagy.	hsa_circ_0085131		hsa_circ_PABPC1	PABPC1	non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0085131 is a PABPC1-derived circRNA upregulated in NSCLC tumor tissues, recurrent NSCLC tissues, and cisplatin-resistant A549/DDP cells. It promotes proliferation, suppresses apoptosis, enhances cisplatin resistance, and drives autophagy through a hsa_circ_0085131/miR-654-5p/ATG7 axis. Clinically, high hsa_circ_0085131 expression is associated with recurrence and poorer OS and RFS in NSCLC patients."	0.8859
32450169	Life sciences	2020	Circular RNA circHIPK3 modulates the proliferation of airway smooth muscle cells by miR-326/STIM1 axis.	hsa_circ_0000284	circHIPK3	hsa_circ_HIPK3	HIPK3	asthma 	MONDO:0004979	asthma	up-regulated	RT-qPCR	"This study reports that circHIPK3 is up-regulated in PDGF-induced human ASMCs, a cellular model related to asthma airway remodeling. circHIPK3 promotes ASMC proliferation and migration while suppressing apoptosis, acting through a cytoplasmic ceRNA mechanism involving miR-326 and STIM1. The circHIPK3/miR-326/STIM1 axis is proposed as a potential therapeutic target for asthma-related airway remodeling."	0.7812
32450188	Neuroscience letters	2020	Knockdown of circHomer1 ameliorates METH-induced neuronal injury through inhibiting Bbc3 expression.		circHomer1	mmu_circ_Homer1	Homer1	methamphetamine-induced neuronal damage 	MONDO:0005465	methamphetamine-induced psychosis	up-regulated	RT-qPCR	"circHomer1 is a mouse Homer1-derived circRNA that is up-regulated after METH treatment in HT-22 cells and is mainly localized in the cytoplasm. Knockdown of circHomer1 alleviates METH-induced neuronal injury and apoptosis, likely through down-regulating Bbc3 in a predicted ceRNA-related mechanism. In METH-conditioned place preference models, circHomer1 expression is correlated with addictive behavior-related measures in brain regions such as the hippocampus."	0.6853
32463418	Biomaterials science	2020	Dicalcium silicate microparticles modulate the differential expression of circRNAs and mRNAs in BMSCs and promote osteogenesis via circ_1983-miR-6931-Gas7 interaction.	mmu_circ_0014738	circ_1983 	mmu_circ_Tacc1	Tacc1	bone defect healing 	MONDO:0005381	bone disorder	up-regulated	RT-qPCR; RNA-seq	"The study identifies mouse circ_1983, also reported as mmu_circ_0014738 from host gene Tacc1, as an upregulated circRNA in C 2 S-treated osteogenically differentiating BMSCs. circ_1983 promotes osteogenic differentiation through a ceRNA mechanism in which it sponges miR-6931, increases Gas7 expression, and supports Runx2-associated osteogenesis. Knockdown of circ_1983 reduces Gas7 and Runx2 expression and inhibits C 2 S-induced osteogenic differentiation."	0.7323
32464246	Gene	2020	Circular RNA hsa_circ_0054537 sponges miR-130a-3p to promote the progression of renal cell carcinoma through regulating cMet pathway.	hsa_circ_0054537				renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR	"hsa_circ_0054537 is up-regulated in RCC cell lines and promotes RCC progression. Mechanistically, it functions as a ceRNA by binding miR-130a-3p, thereby regulating cMet expression and the cMet pathway; inhibition of hsa_circ_0054537 restrains cell growth and migration and promotes apoptosis."	0.627
32468088	Cell and tissue research	2020	CiRS-126 inhibits proliferation of ovarian granulosa cells through targeting the miR-21-PDCD4-ROS axis in a polycystic ovarian syndrome model.		CiRS-126			polycystic ovarian syndrome 	MONDO:0008487	polycystic ovary syndrome	down-regulated	RT-qPCR; Microarray	"ciRS-126 is downregulated in PCOS ovarian samples and insulin-induced granulosa cells. Functional experiments indicate that restoring ciRS-126 suppresses granulosa-cell proliferation and promotes apoptosis by sponging miR-21, increasing PDCD4 expression, and enhancing ROS generation. The study proposes ciRS-126 as a potential diagnostic/prognostic biomarker and therapeutic target for PCOS."	0.7795
32472455	Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico	2020	hsa_circ_0121582 inhibits leukemia growth by dampening Wnt/beta-catenin signaling.	hsa_circ_0121582	circ_0121582	hsa_circ_GSK3beta	GSK3beta	acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0121582 is down-regulated in AML/leukemia and functions as a tumor-suppressive circRNA. It inhibits AML cell proliferation in vitro and in vivo by increasing GSK3beta through miR-224 sponging in the cytoplasm and TET1 recruitment to the GSK3beta promoter in the nucleus, thereby suppressing Wnt/beta-catenin signaling. Its restoration is proposed as a potential therapeutic strategy for AML."	0.8546
32473899	Archives of biochemistry and biophysics	2020	Knockdown of circular RNA circ-FARSA restricts colorectal cancer cell growth through regulation of miR-330-5p/LASP1 axis.		circ-FARSA 	hsa_circ_FARSA	FARSA	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ-FARSA is up-regulated in colorectal cancer tissues and cell lines, and high expression is associated with poorer overall survival. Functionally, circ-FARSA promotes CRC cell proliferation, migration, invasion and xenograft tumor growth. Mechanistically, it acts as a sponge for miR-330-5p to regulate LASP1 expression through the circ-FARSA/miR-330-5p/LASP1 axis."	0.8005
32476580	"Cell cycle (Georgetown, Tex.)"	2020	CircRNA-UBE2G1 regulates LPS-induced osteoarthritis through miR-373/HIF-1a axis.	hsa_circ_0008956	circRNA-UBE2G1	hsa_circ_UBE2G1	UBE2G1	Osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circRNA-UBE2G1 (hsa_circ_0008956) is up-regulated in OA tissues and LPS-treated human C28/I2 chondrocytes, and higher expression correlates with higher modified Mankin scores. Mechanistically, it mainly localizes to the cytoplasm and functions as a ceRNA for miR-373 to regulate HIF-1a, thereby promoting LPS-induced chondrocyte injury, apoptosis, and inflammatory cytokine expression. Its inhibition alleviates LPS-induced OA-like cellular injury, suggesting potential therapeutic value in OA."	0.7295
32486849	"Experimental biology and medicine (Maywood, N.J.)"	2020	CircFADS2: A potential prognostic biomarker of colorectal cancer.		hsa_circ_022382 	hsa_circ_FADS2	FADS2	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circFADS2, also named hsa_circ_022382 in the paper, is derived from the human FADS2 gene and is significantly up-regulated in CRC tissues. Its elevated expression correlates with aggressive clinicopathological features and shorter overall survival, supporting its role as a potential oncogenic prognostic biomarker for CRC. The study did not experimentally define a molecular regulatory mechanism."	0.6895
32500444	Journal of endocrinological investigation	2021	CircTP53 promotes the proliferation of thyroid cancer via targeting miR-1233-3p/MDM2 axis.		CircTP53	hsa_circ_TP53	TP53	thyroid cancer	MONDO:0002108	thyroid cancer	up-regulated	RT-qPCR; ISH	"CircTP53 is up-regulated in thyroid cancer tissues and mainly localizes in the cytoplasm of TPC-1 cells. It promotes thyroid cancer cell proliferation and viability by sponging miR-1233-3p, increasing MDM2 expression, and decreasing p53 protein signaling."	0.8566
32504353	Digestive diseases and sciences	2021	Circular RNA PTK2 Accelerates Cell Proliferation and Inhibits Cell Apoptosis in Gastric Carcinoma via miR-139-3p.	hsa_circ_0003221		hsa_circ_PTK2	PTK2	Gastric carcinoma 	MONDO:0004950	gastric carcinoma	up-regulated	RT-qPCR	"circPTK2 is up-regulated in gastric carcinoma tissues and cell lines. It promotes GC cell proliferation and xenograft tumor growth while inhibiting apoptosis, at least partly by sponging miR-139-3p and regulating proliferation- and apoptosis-related factors including Cyclin A1, PCNA, Bax, and Cleaved caspase-3. Its expression is associated with TNM stage, lymph node metastasis, and tumor size, suggesting potential clinical relevance as a therapeutic target."	0.7032
32506974	Journal of investigative surgery : the official journal of the Academy of Surgical Research	2021	CircRNA 001372 Reduces Inflammation in Propofol-Induced Neuroinflammation and Neural Apoptosis through PIK3CA/Akt/NF-kappaB by miRNA-148b-3p.		circRNA 001372 			propofol-induced neurotoxicity 	MONDO:0005527	toxic encephalopathy	down-regulated	RT-qPCR	"CircRNA 001372 is down-regulated in propofol-induced rat brain injury and functions protectively against neurotoxicity, neuroinflammation, and neural apoptosis. Mechanistically, it antagonizes miRNA-148b-3p and regulates the PI3K/Akt/NF-jB pathway, increasing PI3K/p-Akt signaling and reducing NF-jB-associated inflammatory and apoptotic responses."	0.5637
32511866	Environmental toxicology	2020	CircRNA circ_POLA2 promotes lung cancer cell stemness via regulating the miR-326/GNB1 axis.	hsa_circ_0022812		hsa_circ_POLA2	POLA2	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; ISH	"circ_POLA2 (hsa_circ_0022812), derived from POLA2, is up-regulated in lung cancer tissues and cell lines and high expression indicates poor overall survival. It promotes lung cancer cell stemness by acting as a ceRNA for miR-326, thereby regulating GNB1 expression through the circ_POLA2/miR-326/GNB1 axis. The study suggests circ_POLA2 may serve as a prognostic biomarker and therapeutic target in lung cancer."	0.8647
32522014	Cancer biotherapy & radiopharmaceuticals	2021	"Circle RNA circABCB10 Modulates PFN2 to Promote Breast Cancer Progression, as Well as Aggravate Radioresistance Through Facilitating Glycolytic Metabolism Via miR-223-3p."		circABCB10 	hsa_circ_ABCB10	ABCB10	Breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circABCB10 is up-regulated in breast cancer tissues and cells. It promotes breast cancer progression, glycolysis and irradiation resistance by sponging miR-223-3p and increasing PFN2 expression; circABCB10 knockdown suppresses malignant phenotypes and enhances irradiation sensitivity."	0.6521
32522568	Life sciences	2020	Circular RNA-9119 protects IL-1beta-treated chondrocytes from apoptosis in an osteoarthritis cell model by intercepting the microRNA-26a/PTEN axis.		circRNA-9119 			osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR; Microarray	"CircRNA-9119 is downregulated in OA cartilage and IL-1beta-induced human chondrocyte-like SW1353 cells. Its overexpression promotes chondrocyte viability/proliferation and inhibits apoptosis by sponging miR-26a and restoring PTEN expression, implicating the circRNA-9119/miR-26a/PTEN axis as a potential therapeutic target in OA."	0.7404
32524321	Molecular and cellular biochemistry	2020	CircBPTF knockdown ameliorates high glucose-induced inflammatory injuries and oxidative stress by targeting the miR-384/LIN28B axis in human umbilical vein endothelial cells.	hsa_circ_0045462	circBPTF 	hsa_circ_BPTF	BPTF	HG-induced endothelial dysfunction 	MONDO:0005015	diabetes mellitus	up-regulated	RT-qPCR	"circBPTF is up-regulated in high glucose-induced HUVEC dysfunction and promotes apoptosis, inflammatory cytokine release and oxidative stress. Mechanistically, circBPTF targets miR-384 to enhance LIN28B expression, while circBPTF knockdown alleviates endothelial injury through the miR-384/LIN28B axis."	0.7204
32524420	Journal of molecular neuroscience : MN	2020	Identification of Circular RNA Expression Profiles and their Implication in Spinal Cord Injury Rats at the Immediate Phase.		rno_circRNA_011690 			spinal cord injury 	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR; Microarray	rno_circRNA_011690 was significantly up-regulated in rat spinal cord tissue at 2 h after SCI and showed diagnostic discrimination between SCI and control rats. The study predicted circRNA-miRNA interactions but did not experimentally define its specific downstream mechanism.	0.5922
32524420	Journal of molecular neuroscience : MN	2020	Identification of Circular RNA Expression Profiles and their Implication in Spinal Cord Injury Rats at the Immediate Phase.		rno_circRNA_011494 			spinal cord injury 	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR; Microarray	rno_circRNA_011494 was significantly up-regulated in spinal cord tissue during the immediate phase of SCI. It showed discriminatory value for SCI versus control rats and was included in the predicted circRNA-miRNA interaction network.	0.5922
32524420	Journal of molecular neuroscience : MN	2020	Identification of Circular RNA Expression Profiles and their Implication in Spinal Cord Injury Rats at the Immediate Phase.		rno_circRNA_005470 			spinal cord injury 	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR; Microarray	"rno_circRNA_005470 was significantly up-regulated in the immediate phase of SCI and had diagnostic discrimination for SCI versus control rats. The authors proposed that it may regulate its parental gene membrane-type 1 metalloproteinase and may act as a miR-145-5p sponge, potentially affecting inflammation-related Akt signaling."	0.5922
32524420	Journal of molecular neuroscience : MN	2020	Identification of Circular RNA Expression Profiles and their Implication in Spinal Cord Injury Rats at the Immediate Phase.		rno_circRNA_014301 			spinal cord injury 	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR; Microarray	rno_circRNA_014301 was significantly up-regulated in spinal cord tissue at the immediate phase of SCI. It was predicted to have circRNA-miRNA interactions and showed diagnostic discrimination between SCI and control rats.	0.5922
32524420	Journal of molecular neuroscience : MN	2020	Identification of Circular RNA Expression Profiles and their Implication in Spinal Cord Injury Rats at the Immediate Phase.		rno_circRNA_009608 			spinal cord injury 	MONDO:0043797	spinal cord injury	down-regulated	RT-qPCR; Microarray	"rno_circRNA_009608 was significantly down-regulated in the immediate phase of SCI and could distinguish SCI rats from controls. Its specific downstream mechanism was not experimentally determined, but it was included in a predicted circRNA-miRNA interaction network."	0.5922
32524420	Journal of molecular neuroscience : MN	2020	Identification of Circular RNA Expression Profiles and their Implication in Spinal Cord Injury Rats at the Immediate Phase.		rno_circRNA_016031 			spinal cord injury 	MONDO:0043797	spinal cord injury	down-regulated	RT-qPCR; Microarray	rno_circRNA_016031 was significantly down-regulated in the immediate phase of SCI. It had moderate ability to distinguish SCI rats from controls and was predicted to interact with multiple miRNAs.	0.5922
32524420	Journal of molecular neuroscience : MN	2020	Identification of Circular RNA Expression Profiles and their Implication in Spinal Cord Injury Rats at the Immediate Phase.		rno_circRNA_011497 			spinal cord injury 	MONDO:0043797	spinal cord injury	down-regulated	RT-qPCR; Microarray	"rno_circRNA_011497 was significantly down-regulated in the immediate phase of SCI. It showed the strongest ROC performance among the validated candidates for distinguishing SCI from control rats, while its precise mechanism remained untested."	0.5922
32524420	Journal of molecular neuroscience : MN	2020	Identification of Circular RNA Expression Profiles and their Implication in Spinal Cord Injury Rats at the Immediate Phase.		rno_circRNA_015152 			spinal cord injury 	MONDO:0043797	spinal cord injury	down-regulated	RT-qPCR; Microarray	"rno_circRNA_015152 was significantly down-regulated in the immediate phase of SCI and had discriminatory value for SCI versus control rats. The authors proposed that it may sponge miR-711, potentially connecting it to neuronal cell death, axon damage, angiopoietin-1, and Akt pathways."	0.5922
32534097	Neuroscience letters	2020	Expression of circular RNAs in the vascular dementia rats.		circ_Map2k5	rno_circ_Map2k5	Map2k5	vascular dementia 	MONDO:0004648	vascular dementia	up-regulated	RT-qPCR; RNA-seq	circ_Map2k5 was identified as an up-regulated circRNA in the hippocampus of vascular dementia model rats and validated by qPCR. The study suggests that differentially expressed circRNAs may participate in VD through predicted ceRNA regulation and pathways related to neural function and inflammation.	0.5202
32534097	Neuroscience letters	2020	Expression of circular RNAs in the vascular dementia rats.		circ_Ulk2	rno_circ_Ulk2	Ulk2	vascular dementia 	MONDO:0004648	vascular dementia	up-regulated	RT-qPCR; RNA-seq	circ_Ulk2 was identified as an up-regulated circRNA in the hippocampus of vascular dementia model rats and validated by qPCR. The study links differentially expressed circRNAs to predicted ceRNA networks and VD-related biological processes.	0.5202
32534097	Neuroscience letters	2020	Expression of circular RNAs in the vascular dementia rats.		circ_Plekha5	rno_circ_Plekha5	Plekha5	vascular dementia 	MONDO:0004648	vascular dementia	up-regulated	RT-qPCR; RNA-seq	circ_Plekha5 was identified as an up-regulated circRNA in the hippocampus of vascular dementia model rats and validated by qPCR. Its disease association is based on differential expression and predicted ceRNA-related functional analyses.	0.5202
32534097	Neuroscience letters	2020	Expression of circular RNAs in the vascular dementia rats.		circ_Plcl1	rno_circ_Plcl1	Plcl1	vascular dementia 	MONDO:0004648	vascular dementia	up-regulated	RT-qPCR; RNA-seq	circ_Plcl1 was identified as an up-regulated circRNA in the hippocampus of vascular dementia model rats and validated by qPCR. The paper proposes that altered circRNA expression may contribute to VD through ceRNA networks and inflammation-related pathways.	0.5202
32534097	Neuroscience letters	2020	Expression of circular RNAs in the vascular dementia rats.		circ_Sntg1	rno_circ_Sntg1	Sntg1	vascular dementia 	MONDO:0004648	vascular dementia	up-regulated	RT-qPCR; RNA-seq	circ_Sntg1 was identified as an up-regulated circRNA in the hippocampus of vascular dementia model rats and validated by qPCR. The study suggests its potential involvement in VD as part of broader altered circRNA expression and predicted ceRNA regulation.	0.5202
32534097	Neuroscience letters	2020	Expression of circular RNAs in the vascular dementia rats.		circ_Morc3	rno_circ_Morc3	Morc3	vascular dementia 	MONDO:0004648	vascular dementia	down-regulated	RT-qPCR; RNA-seq	circ_Morc3 was identified as a down-regulated circRNA in the hippocampus of vascular dementia model rats and validated by qPCR. The study suggests that differentially expressed circRNAs may act through predicted circRNA-miRNA-mRNA networks in VD.	0.5202
32534097	Neuroscience letters	2020	Expression of circular RNAs in the vascular dementia rats.		circ_Rims1	rno_circ_Rims1	Rims1	vascular dementia 	MONDO:0004648	vascular dementia	down-regulated	RT-qPCR; RNA-seq	circ_Rims1 was identified as a down-regulated circRNA in the hippocampus of vascular dementia model rats and validated by qPCR. Its potential role is inferred from differential expression and predicted ceRNA/pathway analyses.	0.5202
32534097	Neuroscience letters	2020	Expression of circular RNAs in the vascular dementia rats.		circ_Stxbp5l	rno_circ_Stxbp5l	Stxbp5l	vascular dementia 	MONDO:0004648	vascular dementia	down-regulated	RT-qPCR; RNA-seq	circ_Stxbp5l was identified as a down-regulated circRNA in the hippocampus of vascular dementia model rats and validated by qPCR. The study suggests a possible role for altered circRNAs in VD mechanisms via predicted ceRNA networks.	0.5202
32534097	Neuroscience letters	2020	Expression of circular RNAs in the vascular dementia rats.		circ_Agtpbp1	rno_circ_Agtpbp1	Agtpbp1	vascular dementia 	MONDO:0004648	vascular dementia	down-regulated	RT-qPCR; RNA-seq	circ_Agtpbp1 was identified as a down-regulated circRNA in the hippocampus of vascular dementia model rats and validated by qPCR. The study proposes that such dysregulated circRNAs may influence VD through predicted ceRNA regulation and related pathways.	0.5202
32534097	Neuroscience letters	2020	Expression of circular RNAs in the vascular dementia rats.		circ_Lrrc28	rno_circ_Lrrc28	Lrrc28	vascular dementia 	MONDO:0004648	vascular dementia	down-regulated	RT-qPCR; RNA-seq	circ_Lrrc28 was identified as a down-regulated circRNA in the hippocampus of vascular dementia model rats and validated by qPCR. The paper suggests that differentially expressed circRNAs may be involved in VD pathogenesis through predicted ceRNA networks and inflammation-related processes.	0.5202
32535033	Experimental cell research	2020	Circular RNA-hsa-circ-0000670 promotes gastric cancer progression through the microRNA-384/SIX4 axis.	hsa_circ_0000670	hsa-circRNA-000200 			gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; ISH; Microarray	"hsa-circ-0000670 is up-regulated in gastric cancer tissues and cell lines. It promotes gastric cancer proliferation, migration, invasion, tumor growth, and angiogenesis-related phenotypes by binding miR-384 and up-regulating SIX4, suggesting a potential therapeutic role for targeting hsa-circ-0000670."	0.8508
32535036	Experimental cell research	2020	"Knockdown of circ_0003340 induces cell apoptosis, inhibits invasion and proliferation through miR-564/TPX2 in esophageal cancer cells."	hsa_circ_0003340	Circ_0003340 	hsa_circ_OGDH	OGDH	esophageal cancer 	MONDO:0007576	esophageal cancer	up-regulated	RT-qPCR	"circ3340 is up-regulated in ESCC tissues and esophageal cancer cell lines. Functionally, circ3340 supports proliferation, invasion, migration and tumor growth while suppressing apoptosis, and its knockdown reverses these malignant phenotypes. Mechanistically, circ3340 sponges miR-564 and regulates the miR-564/TPX2 pathway, suggesting potential value as a biomarker or therapeutic target in esophageal cancer."	0.7661
32535085	The Journal of molecular diagnostics : JMD	2020	Identification of Three Circular RNA Cargoes in Serum Exosomes as Diagnostic Biomarkers of Non-Small-Cell Lung Cancer in the Chinese Population.	hsa_circ_0047921	circ_0047921	hsa_circ_CD226	CD226	Non-Small-Cell Lung Cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	"circ_0047921 is a down-regulated serum exosomal circRNA in NSCLC. It was validated by qPCR and splice-junction sequencing and showed diagnostic utility for NSCLC, including early-stage disease and discrimination from COPD controls; a predicted miRNA interaction with let-7g was noted."	0.6556
32535085	The Journal of molecular diagnostics : JMD	2020	Identification of Three Circular RNA Cargoes in Serum Exosomes as Diagnostic Biomarkers of Non-Small-Cell Lung Cancer in the Chinese Population.	hsa_circ_0056285	circ_0056285	hsa_circ_RALB	RALB	Non-Small-Cell Lung Cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	"circ_0056285 is a down-regulated serum exosomal circRNA in NSCLC. It was validated by qPCR and splice-junction sequencing, showed diagnostic utility for NSCLC, and was negatively correlated with disease stage progression and lymphatic metastasis."	0.6556
32535085	The Journal of molecular diagnostics : JMD	2020	Identification of Three Circular RNA Cargoes in Serum Exosomes as Diagnostic Biomarkers of Non-Small-Cell Lung Cancer in the Chinese Population.	hsa_circ_0007761	circ_0007761	hsa_circ_ATXN7	ATXN7	Non-Small-Cell Lung Cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ_0007761 is an up-regulated serum exosomal circRNA in NSCLC. It was validated by qPCR and splice-junction sequencing and showed diagnostic utility for NSCLC, including early-stage disease; in combination with circ_0056285, it helped distinguish NSCLC from TB controls."	0.6556
32540374	Gene	2020	circPUM1 promotes polycystic ovary syndrome progression by sponging to miR-760.		circPUM1	hsa_circ_PUM1		polycystic ovary syndrome 	MONDO:0008487	polycystic ovary syndrome	up-regulated	RT-qPCR	"In this study, circPUM1 was up-regulated in PCOS tissues and insulin-treated granulosa cells/cell lines. circPUM1 promoted PCOS-related granulosa cell viability/proliferation and inhibited apoptosis by sponging miR-760 and decreasing miR-760 expression, suggesting a potential therapeutic target for PCOS."	0.7158
32554046	Gene	2020	Circular RNA circ_0003645 silencing alleviates inflammation and apoptosis via the NF-kappaB pathway in endothelial cells induced by oxLDL.	hsa_circ_0003645	circ_0003645 			Atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR; Microarray	"This study found that circ_0003645 is up-regulated in atherosclerosis patients and oxLDL-induced HUVECs. Functional experiments indicate that circ_0003645 promotes endothelial injury, apoptosis, inflammatory factor and adhesion molecule expression, and suppresses cell viability, at least partly through the NF-kappaB signaling pathway. The authors suggest circ_0003645 as a potential target or biomarker for AS diagnosis and therapy."	0.5821
32559850	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2020	Overexpressed circ-RPL15 predicts poor survival and promotes the progression of gastric cancer via regulating miR-502-3p/OLFM4/STAT3 pathway.		circ-RPL15 	hsa_circ_RPL15		gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ-RPL15 is up-regulated in gastric cancer tissues and cell lines, and high expression predicts poorer overall survival and more aggressive clinicopathological features. Functionally, circ-RPL15 promotes gastric cancer proliferation, migration, invasion and xenograft tumor growth while inhibiting apoptosis. Mechanistically, it acts as a ceRNA for miR-502-3p to regulate OLFM4 and activate the STAT3 pathway."	0.7369
32561093	Surgical oncology	2020	High expression of circulating exosomal circAKT3 is associated with higher recurrence in HCC patients undergoing surgical treatment.		circAKT3 	hsa_circ_AKT3	AKT3	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"This study found that circulating exosomal circAKT3 is up-regulated in serum exosomes from HCC patients compared with healthy subjects. High exosomal circAKT3 is associated with larger tumors, microinvasion, higher recurrence and mortality, and poorer overall and recurrence-free survival, supporting its potential role as a non-invasive prognostic biomarker for postoperative HCC monitoring."	0.5727
32561323	Gene	2020	Circular RNA circ_0001105 protects the intestinal barrier of septic rats by inhibiting inflammation and oxidative damage and YAP1 expression.	rno_circ_0001105	circ_0001105			sepsis 	MONDO:0005229	bacterial infectious disease with sepsis	down-regulated	RT-qPCR	"circ_0001105 is downregulated in intestinal tissues of CLP-induced septic rats. Experimental upregulation of circ_0001105 protects the intestinal barrier by reducing mucosal permeability, inflammation, oxidative injury, and YAP1 expression, and it improves rat survival after sepsis induction."	0.6148
32564659	Cancer biology & therapy	2020	Dysregulated circRNA_100876 contributes to proliferation and metastasis of colorectal cancer by targeting microRNA-516b (miR-516b).		circRNA_100876			colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circRNA_100876 is upregulated in colorectal cancer tissues and cell lines, and high expression is associated with worse clinicopathological features and poor survival. Functionally, circRNA_100876 promotes CRC proliferation, migration, invasion, metastasis and EMT while suppressing apoptosis, at least partly by targeting miR-516b."	0.7078
32568175	Cancer biomarkers : section A of Disease markers	2020	Up-regulation of circ_0000353 impedes the proliferation and metastasis of non-small cell lung cancer cells via adsorbing miR-411-5p and increasing forkhead box O1.	hsa_circ_0000353	circ_0000353			Non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"Circ_0000353 is down-regulated in NSCLC tissues and cell lines, and its reduced expression is associated with advanced clinical features. Functionally, circ_0000353 suppresses NSCLC cell proliferation, migration, invasion and metastasis. Mechanistically, it acts as a ceRNA by adsorbing miR-411-5p, thereby increasing FOXO1 expression."	0.6536
32580576	Cancer biotherapy & radiopharmaceuticals	2022	Circ_0074027 Contributes to Non-Small Cell Lung Cancer Progression by Upregulating CUL4B Expression Through miR-335-5p.	hsa_circ_0074027	circ_0074027	hsa_circ_PITX1	PITX1	nonsmall cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"Circ_0074027 is up-regulated in NSCLC tissues and cells and acts as an oncogenic circRNA. Its knockdown inhibits proliferation, colony formation, cell-cycle progression, and xenograft tumor growth while promoting apoptosis. Mechanistically, circ_0074027 sponges miR-335-5p to up-regulate CUL4B expression."	0.7595
32584497	"BioFactors (Oxford, England)"	2020	Circular RNA DOCK1 downregulates microRNA-124 to induce the growth of human thyroid cancer cell lines.			hsa_circ_DOCK1	DOCK1	thyroid cancer 	MONDO:0002108	thyroid cancer	up-regulated	RT-qPCR	"circDOCK1 is up-regulated in thyroid carcinoma tissues and acts as a pro-tumor circRNA in human thyroid cancer cell lines. The study suggests that circDOCK1 downregulates miR-124, activates JAK/STAT/AMPK signaling, and thereby promotes cell viability, proliferation, migration and invasion."	0.5214
32584521	IUBMB life	2020	CircPDE4B inhibits retinal pathological angiogenesis via promoting degradation of HIF-1alpha though targeting miR-181c.		circPDE4B	hsa_circ_PDE4B	PDE4B	Retinopathy of prematurity 	MONDO:0006952	retinopathy of prematurity	down-regulated	RT-qPCR	"CircPDE4B is downregulated in oxygen-induced retinopathy mouse retina and hypoxia-induced HRECs. Its overexpression suppresses HRECs proliferation, tube formation, VEGFA expression, and pathological angiogenesis by sponging miR-181c to increase VHL and promote ubiquitin-mediated degradation of HIF-1alpha. The study suggests circPDE4B as a potential therapeutic target for retinopathy of prematurity."	0.5607
32588730	"Cell cycle (Georgetown, Tex.)"	2020	Hsa_circ_0009910: oncogenic circular RNA targets microRNA-145 in ovarian cancer cells.	hsa_circ_0009910		hsa_circ_MFN2	MFN2	ovarian cancer	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"hsa_circ_0009910 is up-regulated in ovarian cancer tissues and high expression is associated with poor prognosis. Functionally, it promotes ovarian cancer cell proliferation, viability, migration and invasion. Mechanistically, hsa_circ_0009910 directly targets and suppresses miR-145, contributing to activation of NF-kappaB and Notch signaling."	0.7618
32592202	Journal of cellular physiology	2021	Hsa_circ_001988 attenuates GC progression in vitro and in vivo via sponging miR-197-3p.	hsa_circ_0001451	hsa_circ_001988 	hsa_circ_FBXW7	FBXW7	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"Hsa_circ_001988 is downregulated in gastric cancer tissues and cell lines and functions as a tumor suppressor. It inhibits GC proliferation, colony formation, migration, invasion, EMT and xenograft tumor growth through an EIF4A3/U2AF65-mediated hsa_circ_001988/miR-197-3p/FBXW7 regulatory axis. Its reduced expression is associated with clinicopathological features and it may have diagnostic value for GC."	0.8006
32598170	Cancer biotherapy & radiopharmaceuticals	2024	circ_0080145 Enhances Imatinib Resistance of Chronic Myeloid Leukemia by Regulating miR-326/PPFIA1 Axis.	hsa_circ_0080145				chronic myeloid leukemia 	MONDO:0011996	"chronic myelogenous leukemia, BCR-ABL1 positive"	up-regulated	RT-qPCR	"circ_0080145 is up-regulated in CML, especially in imatinib-resistant CML patients and cells. It enhances imatinib resistance, cell growth, and glycolysis while suppressing apoptosis through the miR-326/PPFIA1 axis. Knockdown of circ_0080145 improves imatinib sensitivity and inhibits tumor growth in a K562/IM xenograft model."	0.6521
32599139	Cellular signalling	2020	Circular RNA TUBA1C accelerates the progression of non-small-cell lung cancer by sponging miR-143-3p.		circTUBA1C 	hsa_circ_TUBA1C	TUBA1C	non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circTUBA1C is up-regulated in NSCLC tissues and cell lines. It promotes NSCLC cell proliferation and xenograft tumor growth while inhibiting apoptosis, at least partly by sponging and negatively regulating miR-143-3p. Knockdown of circTUBA1C suppresses Cyclin B1 and PCNA and increases Bax and cleaved caspase-3, effects that can be rescued by miR-143-3p inhibition."	0.7126
32614609	Cancer biotherapy & radiopharmaceuticals	2022	Circular RNA La-Related Protein 4 Inhibits Non-Small Cell Lung Cancer Cell Proliferation While Promotes Apoptosis Through Sponging microRNA-21-5p.		circular RNA La-related protein 4 	hsa_circ_LARP4	LARP4	nonsmall cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"circ-LARP4 is down-regulated in NSCLC cell lines relative to normal lung epithelial cells. Functional experiments indicate that circ-LARP4 suppresses NSCLC cell proliferation and promotes apoptosis, at least partly by directly binding and negatively regulating miR-21-5p."	0.6263
32619044	Journal of cellular biochemistry	2020	Circular RNA circ_0011269 sponges miR-122 to regulate RUNX2 expression and promotes osteoporosis progression.	hsa_circ_0011269	circ_0011269	hsa_circ_ZCCHC17	ZCCHC17	osteoporosis	MONDO:0005298	osteoporosis	down-regulated	RT-qPCR; Microarray	"circ_0011269 is down-regulated in osteoporosis patient serum/plasma samples and is derived from ZCCHC17. The study supports a circ_0011269/miR-122/RUNX2 ceRNA axis, in which circ_0011269 sponges miR-122 to increase RUNX2 expression and promote osteogenic differentiation markers and ALP activity. Its expression was validated by qRT-PCR in clinical samples, and its interaction mechanism was supported by luciferase reporter and AGO2-RIP assays."	0.7519
32621951	Gene	2020	"Down-regulation of circ_0061140 attenuates ectopic endometrial cell proliferation, migration and invasion in endometriosis via inactivating Notch2."	hsa_circ_0061140	circ_0061140			endometriosis	MONDO:0005133	endometriosis	up-regulated	RT-qPCR	"circ_0061140 is up-regulated in ectopic endometrium from patients with endometriosis. Functionally, circ_0061140 promotes ectopic endometrial cell growth, migration and invasion and suppresses apoptosis. Mechanistically, it acts through a miR-140-3p/Notch2 regulatory axis, suggesting a pathogenic role in endometriosis progression."	0.6542
32629000	Life sciences	2020	circPAN3 exerts a profibrotic role via sponging miR-221 through FoxO3/ATG7-activated autophagy in a rat model of myocardial infarction.		circPAN3	rno_circ_PAN3	PAN3	myocardial infarction 	MONDO:0005068	myocardial infarction	up-regulated	RT-qPCR	"circPAN3 is up-regulated in rat myocardial infarction-associated cardiac fibrosis and in TGFbeta1-stimulated cardiac fibroblasts. It promotes cardiac fibrosis, fibroblast proliferation and migration, and autophagy by sponging miR-221 and modulating the FoxO3/ATG7 axis; circPAN3 knockdown has anti-fibrotic effects in vivo and in vitro."	0.7296
32629026	The international journal of biochemistry & cell biology	2020	Circular RNA circ-ZEB1 acts as an oncogene in triple negative breast cancer via sponging miR-448.		circ-ZEB1	hsa_circ_ZEB1	ZEB1	triple negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"circ-ZEB1 is up-regulated in TNBC tissues and cell lines and functions as an oncogenic circRNA. Its knockdown suppresses TNBC cell proliferation and xenograft tumor growth while promoting apoptosis, likely through the circ-ZEB1/miR-448/eEF2K regulatory axis."	0.7045
32629066	Neuroscience letters	2020	"Down-regulation of circ-PTN suppresses cell proliferation, invasion and glycolysis in glioma by regulating miR-432-5p/RAB10 axis."		circ-PTN 	hsa_circ_PTN	PTN	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ-PTN is up-regulated in glioma tissues and cell lines. Functional experiments indicate that circ-PTN promotes glioma cell proliferation, invasion, glycolysis and xenograft tumor growth. Mechanistically, circ-PTN acts as a ceRNA by binding miR-432-5p and regulating RAB10 expression, suggesting circ-PTN as a potential therapeutic target in glioma."	0.7177
32633558	Human & experimental toxicology	2020	Exosomes derived from mmu_circ_0000623-modified ADSCs prevent liver fibrosis via activating autophagy.	mmu_circ_0000623				liver fibrosis 	MONDO:0100430	fibrotic liver disease	down-regulated	RT-qPCR; Microarray	mmu_circ_0000623 is down-regulated in CCl 4 -induced liver fibrosis mouse liver tissue. Exosomes from mmu_circ_0000623-modified ADSCs deliver mmu_circ_0000623 to suppress liver fibrosis by regulating the miR-125/ATG4D axis and activating autophagy.	0.593
32644821	Cancer biotherapy & radiopharmaceuticals	2021	Exosomal circ-HIPK3 Facilitates Tumor Progression and Temozolomide Resistance by Regulating miR-421/ZIC5 Axis in Glioma.			hsa_circ_HIPK3	HIPK3	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR	"This study found that exosomal circ-HIPK3 is up-regulated in TMZ-resistant glioma cells and serum exosomes. Functionally, circ-HIPK3 promotes glioma progression, invasion, tumor growth and TMZ resistance while suppressing apoptosis, mainly by sponging miR-421 to increase ZIC5 expression. Serum exosomal circ-HIPK3 was proposed as a potential diagnostic biomarker for TMZ-resistant glioma."	0.7045
32644859	Cancer biotherapy & radiopharmaceuticals	2022	Circ_0000745 Promotes the Progression of Cervical Cancer by Regulating miR-409-3p/ATF1 Axis.	hsa_circ_0000745	circ_0000745	hsa_circ_SPECC1	SPECC1	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; ISH	"circ_0000745 is upregulated in cervical cancer tissues and cell lines and is associated with advanced stage and invasion. Functionally, circ_0000745 promotes proliferation, migration, invasion, glycolysis, and xenograft tumor growth. Mechanistically, it acts as a ceRNA for miR-409-3p to activate ATF1, supporting its potential as a therapeutic biomarker for cervical cancer."	0.7884
32646340	"Cell cycle (Georgetown, Tex.)"	2020	Circular RNA circDLGAP4 is involved in lung cancer development through modulating microRNA-143/CDK1 axis.		circular RNA DLGAP4 	hsa_circ_DLGAP4	DLGAP4	lung cancer 	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circDLGAP4 is up-regulated in lung cancer tissues and cell lines and is associated with advanced TNM stage and metastasis. Functionally, it promotes malignant lung cancer cell behaviors through a miR-143/CDK1 regulatory axis and may have biomarker potential for diagnosis or treatment."	0.6536
32653519	Life sciences	2020	circ_KIAA1429 accelerates hepatocellular carcinoma advancement through the mechanism of m6A-YTHDF3-Zeb1.	hsa_circ_0084922	circ_KIAA1429 	hsa_circ_KIAA1429	KIAA1429	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circ_KIAA1429/hsa_circ_0084922 is derived from KIAA1429 and is upregulated in HCC tissues and cell lines. It promotes HCC migration, invasion, metastasis and EMT, at least partly by maintaining Zeb1 expression through an m6A-YTHDF3-Zeb1 mechanism that enhances Zeb1 mRNA stability. The study suggests circ_KIAA1429 may be a potential therapeutic target in HCC."	0.8162
32657138	Epigenomics	2020	hsa_circ_0001947 suppresses acute myeloid leukemia progression via targeting hsa-miR-329-5p/CREBRF axis.	hsa_circ_0001947		hsa_circ_AFF2	AFF2	acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	down-regulated	RT-qPCR; Microarray	"hsa_circ_0001947 is downregulated in AML and acts as a tumor suppressor. It inhibits AML cell proliferation and promotes apoptosis by sponging hsa-miR-329-5p and relieving repression of CREBRF, and it also shows diagnostic/prognostic potential in patient samples."	0.8162
32657141	Epigenomics	2020	Circular RNA expression profile and m6A modification analysis in poorly differentiated adenocarcinoma of the stomach.	hsa_circ_0102434		hsa_circ_NUP54	NUP54	poorly differentiated gastric adenocarcinoma 	MONDO:0005036	gastric adenocarcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0102434 was up-regulated in PDGA tissues and validated by RT-qPCR. It showed diagnostic potential for both gastric cancer and PDGA, and its m6A level was significantly correlated with its expression level."	0.6709
32657141	Epigenomics	2020	Circular RNA expression profile and m6A modification analysis in poorly differentiated adenocarcinoma of the stomach.	hsa_circ_0005505		hsa_circ_EPB41L2	EPB41L2	poorly differentiated gastric adenocarcinoma 	MONDO:0005036	gastric adenocarcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0005505 was up-regulated in PDGA and validated by RT-qPCR. It had diagnostic potential for both GC and PDGA, and its m6A level significantly correlated with circRNA expression."	0.6709
32657141	Epigenomics	2020	Circular RNA expression profile and m6A modification analysis in poorly differentiated adenocarcinoma of the stomach.	hsa_circ_0077837		hsa_circ_LIFR	LIFR	poorly differentiated gastric adenocarcinoma 	MONDO:0005036	gastric adenocarcinoma	down-regulated	RT-qPCR; Microarray	hsa_circ_0077837 was down-regulated in PDGA/GC and validated by RT-qPCR. It had the strongest diagnostic performance among the selected circRNAs for both GC and PDGA.	0.6709
32657141	Epigenomics	2020	Circular RNA expression profile and m6A modification analysis in poorly differentiated adenocarcinoma of the stomach.	hsa_circ_0072309		hsa_circ_IRAK3	IRAK3	poorly differentiated gastric adenocarcinoma 	MONDO:0005036	gastric adenocarcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0072309 was down-regulated in PDGA/GC and validated by RT-qPCR. It was proposed as a diagnostic marker for GC and PDGA, and its m6A modification level correlated with expression."	0.6709
32657141	Epigenomics	2020	Circular RNA expression profile and m6A modification analysis in poorly differentiated adenocarcinoma of the stomach.	hsa_circ_0070033		hsa_circ_FUT8	FUT8	poorly differentiated gastric adenocarcinoma 	MONDO:0005036	gastric adenocarcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0070033 was down-regulated in PDGA and validated by RT-qPCR. It was proposed as a PDGA-specific diagnostic signature, although its diagnostic performance for overall GC was not significant."	0.6709
32657141	Epigenomics	2020	Circular RNA expression profile and m6A modification analysis in poorly differentiated adenocarcinoma of the stomach.	hsa_circ_0001727	hsa circ 0001727			poorly differentiated gastric adenocarcinoma 	MONDO:0005036	gastric adenocarcinoma	up-regulated	Microarray	"hsa circ 0001727 was identified as an up-regulated DEC by microarray. Its m6A modification level was significantly correlated with its expression, suggesting possible involvement of m6A modification in PDGA/GC progression."	0.3858
32657141	Epigenomics	2020	Circular RNA expression profile and m6A modification analysis in poorly differentiated adenocarcinoma of the stomach.	hsa_circ_0016601	hsa circ 0016601			poorly differentiated gastric adenocarcinoma 	MONDO:0005036	gastric adenocarcinoma	up-regulated	Microarray	"hsa circ 0016601 was identified as an up-regulated DEC by microarray. Its m6A modification level was significantly correlated with expression, linking it to m6A-related circRNA dysregulation in PDGA/GC."	0.3858
32657141	Epigenomics	2020	Circular RNA expression profile and m6A modification analysis in poorly differentiated adenocarcinoma of the stomach.	hsa_circ_0071261	hsa circ 0071261			poorly differentiated gastric adenocarcinoma 	MONDO:0005036	gastric adenocarcinoma	down-regulated	Microarray	"hsa circ 0071261 was identified as a down-regulated DEC by microarray. Its m6A modification level significantly correlated with its expression, suggesting a possible m6A-related role in PDGA/GC progression."	0.3858
32658600	RNA biology	2020	Circular RNA circ-LDLRAD3 serves as an oncogene to promote non-small cell lung cancer progression by upregulating SLC1A5 through sponging miR-137.	hsa_circ_0006988	circ-LDLRAD3	hsa_circ_LDLRAD3	LDLRAD3	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ-LDLRAD3 is up-regulated in NSCLC tissues and cell lines and is associated with advanced TNM stage and lymphatic metastasis. Functionally, it promotes NSCLC cell proliferation and invasion while suppressing apoptosis. Mechanistically, circ-LDLRAD3 sponges miR-137 to up-regulate SLC1A5, forming a circ-LDLRAD3/miR-137/SLC1A5 oncogenic axis."	0.7181
32663980	Journal of affective disorders	2020	Plasma Circular RNA DYM Related to Major Depressive Disorder and Rapid Antidepressant Effect Treated by Visual Cortical Repetitive Transcranial Magnetic Stimulation.		circRNA DYM 	hsa_circ_DYM	DYM	major depressive disorder 	MONDO:0002009	major depressive disorder	down-regulated	RT-qPCR	"This clinical study validated that plasma circDYM is significantly reduced in patients with major depressive disorder compared with normal controls. circDYM levels increased after five days of real visual cortical rTMS, and ROC analyses suggested potential diagnostic and treatment-response predictive value."	0.4187
32667692	Journal of cellular physiology	2021	circNFATC3 sponges miR-548I acts as a ceRNA to protect NFATC3 itself and suppressed hepatocellular carcinoma progression.	hsa_circ_0000711	circNFATC3 	hsa_circ_NFATC3	NFATC3	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"circNFATC3 is downregulated in HCC tissues and cell lines and acts as a tumor suppressor. It sponges miR-548I to protect/upregulate its host gene NFATC3, suppressing JNK/c-Jun/AKT/mTOR phosphorylation and thereby inhibiting proliferation, migration, invasion, tumor growth and metastasis while promoting apoptosis. The study suggests circNFATC3 may serve as a biomarker and potential therapeutic target for HCC."	0.8275
32668286	Experimental and molecular pathology	2020	Circ_DCAF6 potentiates cell stemness and growth in breast cancer through GLI1-Hedgehog pathway.		circ_DCAF6	hsa_circ_DCAF6	DCAF6	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_DCAF6 is up-regulated in breast cancer cell lines and promotes breast cancer cell growth and stemness. Mechanistically, cytoplasmic circ_DCAF6 sponges miR-616-3p to increase GLI1 expression and activate the GLI1-dependent Hedgehog pathway."	0.7909
32673066	Cancer biotherapy & radiopharmaceuticals	2021	"Circular RNA circ_0091579 Promotes Hepatocellular Carcinoma Proliferation, Migration, Invasion, and Glycolysis Through miR-490-5p/CASC3 Axis."	hsa_circ_0091579	circ_0091579	hsa_circ_GPC3	GPC3	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0091579 is upregulated in HCC and mainly acts as an oncogenic circRNA. It sponges miR-490-5p to relieve repression of CASC3, thereby promoting proliferation, migration, invasion, and glycolysis in HCC cells."	0.814
32673817	Molecular immunology	2020	Hsa_circ_0088036 promotes the proliferation and migration of fibroblast-like synoviocytes by sponging miR-140-3p and upregulating SIRT 1 expression in rheumatoid arthritis.	hsa_circ_0088036		hsa_circ_SUSD1	SUSD1	rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"hsa_circ_0088036/circ0088036 is upregulated in RA fibroblast-like synoviocytes. It promotes RA-FLS proliferation and migration by sponging miR-140-3p and increasing SIRT 1 expression, suggesting a pro-inflammatory role and potential therapeutic relevance in RA."	0.6479
32674051	International immunopharmacology	2020	IFN regulatory Factor-1 induced macrophage pyroptosis by modulating m6A modification of circ_0029589 in patients with acute coronary syndrome.	hsa_circ_0029589				acute coronary syndrome 	MONDO:0005542	acute coronary syndrome	down-regulated	RT-qPCR	"In this study, hsa_circ_0029589 was significantly down-regulated in PBMC-derived macrophages from ACS patients, while its m6A modification level was increased. IRF-1 promoted METTL3 expression and m6A modification of circ_0029589, suppressing circ_0029589 and facilitating macrophage pyroptosis and inflammatory responses. Restoring circ_0029589 expression or inhibiting METTL3 attenuated IRF-1-induced pyroptosis, suggesting a potential therapeutic mechanism in ACS and AS."	0.682
32678674	Cancer biotherapy & radiopharmaceuticals	2021	"Knockdown of Circ_0081143 Mitigates Hypoxia-Induced Migration, Invasion, and EMT in Gastric Cancer Cells Through the miR-497-5p/EGFR Axis."	hsa_circ_0081143		hsa_circ_COL1A2	COL1A2	Gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_0081143 is up-regulated in gastric cancer tissues and cells and is further induced by hypoxia in GC cells. Functionally, circ_0081143 promotes hypoxia-induced migration, invasion, and EMT, while its knockdown suppresses these malignant behaviors. Mechanistically, circ_0081143 acts as a ceRNA for miR-497-5p to modulate EGFR expression, suggesting therapeutic potential in GC."	0.6369
32681834	Molecular therapy : the journal of the American Society of Gene Therapy	2020	Circular RNA circSnx5 Controls Immunogenicity of Dendritic Cells through the miR-544/SOCS1 Axis and PU.1 Activity Regulation.		circSnx5 	mmu_circ_Snx5	snx5 / Snx5	acute rejection after cardiac transplantation 	MONDO:1010187	acute transplant rejection	dysregulated	RT-qPCR; ISH; Microarray	"circSnx5 is a mouse Snx5-derived circRNA enriched in dendritic cells and functionally linked to DC immune status. It promotes tolerogenic DC functions and suppresses inflammatory DC activation through the miR-544/SOCS1 axis and by binding PU.1 to limit nuclear translocation and MHC class II expression. In vivo, transfer of circSnx5-overexpressing DCs prolonged cardiac allograft survival and reduced inflammation in experimental autoimmune myocarditis."	0.8519
32683074	Gene	2020	Circular RNA Circ_0000064 promotes the proliferation and fibrosis of mesangial cells via miR-143 in diabetic nephropathy.	mmu_circ_0000064				diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"Circ_0000064 is up-regulated in high-glucose-treated mouse mesangial cells used as a diabetic nephropathy model. It promotes mesangial cell proliferation and fibrosis and inhibits apoptosis, at least partly by suppressing miR-143. The study suggests circ_0000064/miR-143 as a preliminary regulatory axis and potential DN biomarker candidate, without clinical validation."	0.3957
32683589	Digestive diseases and sciences	2021	Hsa-circRNA-103809 Promotes Hepatocellular Carcinoma Development via MicroRNA-1270/PLAG1 Like Zinc Finger 2 Axis.		hsa-circRNA-103809 			hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circRNA-103809 is up-regulated in HCC cell lines and acts as an oncogenic circRNA. It promotes proliferation, migration, invasion and EMT by sponging miR-1270 and increasing PLAGL2 expression, forming a circRNA-103809/miR-1270/PLAGL2 ceRNA axis with potential biomarker and therapeutic relevance."	0.7006
32694641	Nature metabolism	2019	Adipose circular RNAs exhibit dynamic regulation in obesity and functional role in adipogenesis.		circTshz2-1	mmu_circ_Tshz2	Tshz2	obesity 	MONDO:0011122	obesity disorder	down-regulated	RT-qPCR; RNA-seq	"circTshz2-1 is a mouse adipose-enriched circRNA derived from the Tshz2 locus. It is downregulated in adipose tissue during diet-induced obesity and promotes adipocyte differentiation, as its specific knockdown inhibits lipid accumulation and adipogenic marker expression."	0.6862
32694641	Nature metabolism	2019	Adipose circular RNAs exhibit dynamic regulation in obesity and functional role in adipogenesis.		circArhgap5-2	mmu_circ_Arhgap5	Arhgap5	obesity 	MONDO:0011122	obesity disorder	down-regulated	RT-qPCR; RNA-seq	"circArhgap5-2 is a mouse circRNA derived from the Arhgap5 locus that is downregulated in adipose tissue under high-fat diet-induced obesity. It promotes adipogenesis and maintains mature adipocyte transcriptional programs, including lipid metabolic pathways, while its depletion induces inflammatory gene programs. The study ruled out miRNA sponge activity, AGO2 binding, peptide translation, and nuclear localization as likely mechanisms, leaving the precise mechanism unresolved."	0.7548
32694641	Nature metabolism	2019	Adipose circular RNAs exhibit dynamic regulation in obesity and functional role in adipogenesis.		circARHGAP5-1	hsa_circ_ARHGAP5	ARHGAP5	obesity 	MONDO:0011122	obesity disorder	unknown	RT-qPCR; RNA-seq	"circARHGAP5-1 is the human homologous circRNA from the ARHGAP5 locus. Although its obesity-specific expression change was not established, functional knockdown in immortalized human white fat progenitor cells suppressed adipogenesis and lipid accumulation, suggesting conservation of the pro-adipogenic ARHGAP5 circRNA function in humans."	0.3684
32707273	Environment international	2020	Circular RNA circBbs9 promotes PM2.5-induced lung inflammation in mice via NLRP3 inflammasome activation.		circ_025436 	mmu_circ_Bbs9	Bbs9	PM2.5-induced lung inflammation 	MONDO:0043905	pneumonitis	up-regulated	RT-qPCR; ISH; RNA-seq	"circBbs9 is a mouse Bbs9-derived circRNA upregulated in lung tissue, blood, and RAW264.7 cells after PM2.5 exposure, with stronger expression in COPD model mice exposed to PM2.5. It promotes PM2.5-induced lung inflammation by sponging miR-30e-5p, increasing Adar expression, and activating the NLRP3 inflammasome pathway, thereby increasing IL-1beta and IL-18. The study suggests circBbs9 may be an inflammatory indicator or assessment target for PM2.5-induced lung inflammation and COPD exacerbation."	0.7694
32707301	Gene	2020	Circ_0123996 promotes cell proliferation and fibrosisin mouse mesangial cells through sponging miR-149-5p and inducing Bach1 expression.	hsa_circ_0123996	circ_0123996			Diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"circ_0123996 is up-regulated in diabetic nephropathy patient kidney tissues, STZ-induced DN animal models, and high-glucose-treated mouse mesangial cells. Functionally, it promotes mesangial cell proliferation and fibrosis-related FN and Col-4 expression. Mechanistically, circ_0123996 acts as a miR-149-5p sponge to induce Bach1 expression, suggesting the circ_0123996/miR-149-5p/Bach1 axis as a potential therapeutic target for DN."	0.705
32716343	Cancer biomarkers : section A of Disease markers	2020	"Circ_0000376 enhances the proliferation, metastasis, and chemoresistance of NSCLC cells via repressing miR-384."	hsa_circ_0000376	circ_0000376			Non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"Circ_0000376 is up-regulated in NSCLC tissues and cell lines and is associated with unfavorable clinicopathological indicators. Functionally, it promotes proliferation, migration, invasion, EMT, metastasis, and cisplatin chemoresistance of NSCLC cells. Mechanistically, circ_0000376 binds to miR-384 and represses its expression, thereby contributing to malignant phenotypes in NSCLC."	0.6536
32716640	Cancer biotherapy & radiopharmaceuticals	2022	Knockdown of Circ_CCNB2 Sensitizes Prostate Cancer to Radiation Through Repressing Autophagy by the miR-30b-5p/KIF18A Axis.		circRNA Cyclin B2 	hsa_circ_CCNB2	CCNB2	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circ_CCNB2 is upregulated in prostate cancer, especially in irradiation-resistant PCa tissues and cells. It promotes radioresistance by sponging miR-30b-5p to increase KIF18A expression and enhance autophagy; knockdown of circ_CCNB2 sensitizes PCa cells and xenografts to radiation."	0.7045
32729955	The journal of gene medicine	2020	Circ_0000105 promotes liver cancer by regulating miR-498/PIK3R1.	hsa_circ_0000105	circ_0000105 	hsa_circ_CD53	CD53	liver cancer	MONDO:0002691	liver cancer	up-regulated	RT-qPCR	"Circ_0000105 is up-regulated in human liver cancer tissues and cell lines. It promotes liver cancer cell proliferation and suppresses apoptosis by sponging miR-498 and indirectly increasing PIK3R1 expression. Clinically, high circ_0000105 expression is associated with more advanced T stage, low tumor differentiation, and poorer prognosis."	0.7581
32729957	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2020	Circular RNA 000554 represses epithelial-mesenchymal transition in breast cancer by regulating microRNA-182/ZFP36 axis.	hsa_circ_0000376	circRNA_000554 			breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	"circRNA_000554 is down-regulated in breast cancer tissues and cell lines, and higher expression is associated with better patient survival. Functionally, circRNA_000554 suppresses EMT, migration, invasion, and xenograft tumor growth while promoting apoptosis and autophagy. Mechanistically, cytoplasmic circRNA_000554 sponges miR-182 to upregulate ZFP36, forming a circRNA_000554/miR-182/ZFP36 tumor-suppressive axis."	0.8769
32734834	Tumori	2021	Clinical significance of circPVT1 in patients with non-small cell lung cancer who received cisplatin combined with gemcitabine chemotherapy.		circPVT1	hsa_circ_PVT1		non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"This clinical study found that serum circPVT1 is up-regulated in NSCLC before chemotherapy and decreases after cisplatin plus gemcitabine treatment. Higher circPVT1 expression is associated with chemotherapy resistance, advanced clinical features, and poorer survival, suggesting its potential clinical value for prognosis and therapy-response assessment."	0.4758
32735753	Andrology	2020	Over-expression of hsa_circ_0000116 in patients with non-obstructive azoospermia and its predictive value in testicular sperm retrieval.	hsa_circ_0000116				non-obstructive azoospermia 	MONDO:0100459	azoospermia	up-regulated	RT-qPCR	"hsa_circ_0000116 is significantly up-regulated in testicular tissue from NOA patients, especially SCOS cases, compared with OA controls. Its high expression correlates with poorer spermatogenic status and lower successful sperm retrieval, and it may regulate spermatogenesis through a miR-449/autophagy-related ceRNA network. The study suggests hsa_circ_0000116 as a potential NOA biomarker and predictor of testicular sperm retrieval outcome."	0.5545
32735888	Life sciences	2020	Circular RNA hsa_circ_0001588 promotes the malignant progression of lung adenocarcinoma by modulating miR-524-3p/NACC1 signaling.	hsa_circ_0001588		hsa_circ_HIST1H4E	HIST1H4E	lung adenocarcinoma	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"hsa_circ_0001588 is upregulated in lung adenocarcinoma tissues and cell lines and high expression is associated with poor clinicopathological features and adverse prognosis. Functionally, it promotes proliferation, migration, invasion, metastasis, and in vivo tumor growth. Mechanistically, cytoplasmic hsa_circ_0001588 acts as a ceRNA for miR-524-3p to increase NACC1 expression, supporting its potential as a therapeutic target."	0.8162
32736703	Biochemical and biophysical research communications	2020	Suppression of circular RNA circDHCR24 alleviates aortic smooth muscle cell proliferation and migration by targeting miR-149-5p/MMP9 axis.	hsa_circ_0113656		hsa_circ_DHCR24	DHCR24	vascular restenosis after PCI 	MONDO:0005385	vascular disorder	up-regulated	RT-qPCR; Microarray	"circDHCR24 is up-regulated in PDGF-BB-induced human aortic vascular smooth muscle cells. It promotes VSMC proliferation, migration and phenotypic switch by acting as a sponge for miR-149-5p and regulating MMP9, suggesting a role in vascular restenosis."	0.7296
32736703	Biochemical and biophysical research communications	2020	Suppression of circular RNA circDHCR24 alleviates aortic smooth muscle cell proliferation and migration by targeting miR-149-5p/MMP9 axis.	hsa_circ_0001636				vascular restenosis after PCI 	MONDO:0005385	vascular disorder	up-regulated	RT-qPCR; Microarray	hsa_circ_0001636 was identified by circRNA microarray and validated by qRT-PCR as significantly up-regulated in PDGF-BB-induced HA-VSMCs. The study did not further investigate its function or mechanism.	0.1904
32736703	Biochemical and biophysical research communications	2020	Suppression of circular RNA circDHCR24 alleviates aortic smooth muscle cell proliferation and migration by targeting miR-149-5p/MMP9 axis.		hsa_circ_00009732 			vascular restenosis after PCI 	MONDO:0005385	vascular disorder	up-regulated	RT-qPCR; Microarray	has_-circ_00009732 / has_circ_00009732 was identified by circRNA microarray and validated by qRT-PCR as significantly up-regulated in PDGF-BB-induced HA-VSMCs. The study did not further investigate its function or mechanism.	0.1904
32737775	Molecular and cellular biochemistry	2020	"Circ-PVT1/miR-106a-5p/HK2 axis regulates cell growth, metastasis and glycolytic metabolism of oral squamous cell carcinoma."			hsa_circ_PVT1	PVT1	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"Circ-PVT1 is up-regulated in OSCC tissues and cell lines. It acts as an oncogenic circRNA by sponging miR-106a-5p to increase HK2 expression, promoting cell growth, migration, invasion, glycolytic metabolism and xenograft tumor growth while inhibiting apoptosis."	0.7177
32739469	Life sciences	2020	Circular RNA PRKCI silencing represses esophageal cancer progression and elevates cell radiosensitivity through regulating the miR-186-5p/PARP9 axis.		Circular RNA PRKCI 	hsa_circ_PRKCI	PRKCI	esophageal cancer 	MONDO:0007576	esophageal cancer	up-regulated	RT-qPCR	"circPRKCI is upregulated in esophageal cancer tissues and cells. It acts as an oncogenic circRNA that promotes EC cell viability, colony formation, cell cycle progression, tumor growth, and radioresistance. Mechanistically, circPRKCI sponges miR-186-5p to increase PARP9 expression, and its silencing suppresses EC progression and enhances radiosensitivity."	0.7595
32740683	Digestive diseases and sciences	2021	CircRNA Hsa_circ_0001017 Inhibited Gastric Cancer Progression via Acting as a Sponge of miR-197.	hsa_circ_0001017				gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"hsa_circ_0001017 is down-regulated in gastric cancer tissues and cell lines. Its overexpression suppresses gastric cancer cell proliferation, migration, invasion, and xenograft tumor growth by sponging miR-197 and promoting RHOB expression, suggesting potential therapeutic biomarker value."	0.6536
32741666	Clinical breast cancer	2020	circCDYL Acts as a Tumor Suppressor in Triple Negative Breast Cancer by Sponging miR-190a-3p and Upregulating TP53INP1.		circCDYL	hsa_circ_CDYL	CDYL	triple negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	down-regulated	RT-qPCR	"circCDYL is down-regulated in triple negative breast cancer tissues and cell lines, and higher expression is associated with longer patient survival. Functionally, circCDYL acts as a tumor suppressor by sponging miR-190a-3p, thereby up-regulating TP53INP1 and promoting apoptosis while inhibiting proliferation, migration, and invasion."	0.7113
32750152	"Hepatology (Baltimore, Md.)"	2021	"A Circular RNA, Cholangiocarcinoma-Associated Circular RNA 1, Contributes to Cholangiocarcinoma Progression, Induces Angiogenesis, and Disrupts Vascular Endothelial Barriers."		hsa_circRNA_102064 	hsa_circ_ERBB2	ERBB2	cholangiocarcinoma 	MONDO:0019087	cholangiocarcinoma	up-regulated	RT-qPCR; ISH; RNA-seq; Microarray	"circ-CCAC1 is an ERBB2-derived circRNA upregulated in CCA tissues and bile/serum EVs. It promotes CCA progression via the miR-514a-5p/YY1/CAMLG axis and exosomal circ-CCAC1 disrupts endothelial barriers and induces angiogenesis by sequestering EZH2 and modulating SH3GL2/ZO-1/Occludin signaling. High circ-CCAC1 expression is associated with poor prognosis, recurrence, adverse clinicopathological features, and diagnostic potential in EVs."	0.9046
32750152	"Hepatology (Baltimore, Md.)"	2021	"A Circular RNA, Cholangiocarcinoma-Associated Circular RNA 1, Contributes to Cholangiocarcinoma Progression, Induces Angiogenesis, and Disrupts Vascular Endothelial Barriers."		hsa_circRNA_100364			cholangiocarcinoma 	MONDO:0019087	cholangiocarcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"hsa_circRNA_100364 was detected as an upregulated circRNA in bile-derived EVs from CCA patients. The article evaluated its diagnostic relevance, but reported that its performance for predicting eCCA was limited compared with circ-CCAC1."	0.5267
32758011	Cancer biotherapy & radiopharmaceuticals	2022	Circ_0109291 Promotes Cisplatin Resistance of Oral Squamous Cell Carcinoma by Sponging miR-188-3p to Increase ABCB1 Expression.	hsa_circ_0109291				oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"This study shows that circ_0109291 is up-regulated in OSCC, especially in DDP-resistant OSCC tissues and cells. Functionally, circ_0109291 promotes proliferation and cisplatin resistance while suppressing apoptosis, and its knockdown increases tumor sensitivity to DDP in vivo. Mechanistically, circ_0109291 sponges miR-188-3p to regulate ABCB1 expression, forming a circ_0109291/miR-188-3p/ABCB1 axis involved in OSCC chemoresistance."	0.7289
32762552	Genetic testing and molecular biomarkers	2020	The Circular RNA CDR1as Regulates the Proliferation and Apoptosis of Human Cardiomyocytes Through the miR-135a/HMOX1 and miR-135b/HMOX1 Axes.		CDR1as	hsa_circ_CDR1	CDR1	Chronic heart failure 	MONDO:0005252	heart failure	up-regulated	RT-qPCR	"CDR1as is upregulated in the plasma of patients with chronic heart failure and shows diagnostic potential, with expression associated with NYHA class, LVEF, and BNP. Mechanistically, CDR1as acts as a sponge for miR-135a and miR-135b to regulate HMOX1, thereby promoting cardiomyocyte proliferation and inhibiting apoptosis in vitro."	0.7113
32767026	Molecular and cellular biochemistry	2020	"Circular RNA hsa_circ_0096157 contributes to cisplatin resistance by proliferation, cell cycle progression, and suppressing apoptosis of non-small-cell lung carcinoma cells."	hsa_circ_0096157		hsa_circ_MALAT1	MALAT1	non-small-cell lung carcinoma 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0096157 is up-regulated in Cisplatin-resistant A549/DDP NSCLC cells. Functional knockdown and overexpression experiments indicate that it promotes Cisplatin resistance by enhancing proliferation, migration, invasion, and cell cycle progression while suppressing apoptosis, accompanied by regulation of cell cycle and EMT-related proteins."	0.6591
32767026	Molecular and cellular biochemistry	2020	"Circular RNA hsa_circ_0096157 contributes to cisplatin resistance by proliferation, cell cycle progression, and suppressing apoptosis of non-small-cell lung carcinoma cells."	hsa_circ_0030411				non-small-cell lung carcinoma 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0030411 was identified by sequencing and validated by qRT-PCR as significantly elevated in Cisplatin-resistant A549/DDP NSCLC cells compared with A549 cells. No functional mechanism or clinical association was further tested for this circRNA in the article.	0.1904
32767026	Molecular and cellular biochemistry	2020	"Circular RNA hsa_circ_0096157 contributes to cisplatin resistance by proliferation, cell cycle progression, and suppressing apoptosis of non-small-cell lung carcinoma cells."	hsa_circ_0005941		hsa_circ_FTO	FTO	non-small-cell lung carcinoma 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005941 was identified by sequencing and validated by qRT-PCR as suppressed in Cisplatin-resistant A549/DDP cells compared with A549 cells. The authors noted that it is derived from FTO and speculated it may be involved in A549/DDP resistance to cisplatin, but no direct functional mechanism was tested."	0.1904
32768524	Cancer letters	2020	Targeting the radiation-induced TR4 nuclear receptor-mediated QKI/circZEB1/miR-141-3p/ZEB1 signaling increases prostate cancer radiosensitivity.	hsa_circ_0004907		hsa_circ_ZEB1	ZEB1	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"In prostate cancer models, radiation-induced TR4 increases QKI expression, thereby elevating circZEB1. Cytoplasmic circZEB1 promotes radioresistance by sponging miR-141-3p and increasing ZEB1 protein expression, which supports DNA damage repair and protects cells from IR-induced apoptosis. Targeting this TR4/QKI/circZEB1/miR-141-3p/ZEB1 axis may improve PCa radiosensitivity."	0.8058
32768781	The Science of the total environment	2020	Circ0061052 regulation of FoxC1/Snail pathway via miR-515-5p is involved in the epithelial-mesenchymal transition of epithelial cells during cigarette smoke-induced airway remodeling.	hsa_circ_0061052	circ0061052	hsa_circ_OSBPL2	OSBPL2	chronic obstructive pulmonary disease 	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR	"Circ0061052 is up-regulated after cigarette smoke/CSE exposure and promotes EMT associated with airway remodeling in COPD models. Mechanistically, cytoplasmic circ0061052 sponges miR-515-5p to relieve repression of FoxC1, leading to FoxC1/Snail activation and EMT marker changes."	0.7489
32768931	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2020	Circular RNA YAP1 attenuates osteoporosis through up-regulation of YAP1 and activation of Wnt/beta-catenin pathway.	hsa_circ_0024097	Circ_0024097		YAP1	osteoporosis	MONDO:0005298	osteoporosis	up-regulated	RT-qPCR	"circ_0024097 is a YAP1-derived circRNA that is up-regulated during osteoblastic differentiation of BMSCs and MC3T3-E1 cells. It functions as a ceRNA for miR-376b-3p, increasing YAP1 expression and activating Wnt/beta-catenin signaling to promote osteogenic differentiation and attenuate osteoporosis-related defects."	0.7322
32768951	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2020	Circ_0067934 promotes non-small cell lung cancer development by regulating miR-1182/KLF8 axis and activating Wnt/beta-catenin pathway.	hsa_circ_0067934	circ_0067934	hsa_circ_PRKCI	PRKCI	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"Circ_0067934 is up-regulated in NSCLC tissues and cells. It promotes NSCLC progression by acting as a ceRNA for miR-1182, thereby regulating KLF8 and activating the Wnt/beta-catenin pathway. Silencing circ_0067934 inhibits proliferation, migration, invasion, EMT and tumor growth, while inducing apoptosis."	0.7289
32777532	Gene	2020	Downregulated circular RNA zRANB1 mediates Wnt5a/beta-Catenin signaling to promote neuropathic pain via miR-24-3p/LPAR3 axis in CCI rat models.		cZRANB1 	rno_circ_ZRANB1	ZRANB1	neuropathic pain 	MONDO:0021667	neuralgia	down-regulated	RT-qPCR	"cZRANB1 is downregulated in CCI rat models of neuropathic pain. It acts as a sponge for miR-24-3p to regulate LPAR3 and Wnt5a/beta-Catenin signaling, and cZRANB1 overexpression alleviates mechanical allodynia and thermal hyperalgesia."	0.642
32778770	Cancer gene therapy	2021	circRACGAP1 promotes non-small cell lung cancer proliferation by regulating miR-144-5p/CDKL1 signaling pathway.		hsa_circRNA_101053 	hsa_circ_RACGAP1	RACGAP1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circRACGAP1 is up-regulated in NSCLC tissues and cell lines and high expression is associated with poorer patient survival. Functionally, circRACGAP1 promotes NSCLC proliferation, cell-cycle progression, tumor growth, and Gefitinib resistance. Mechanistically, it acts as a miR-144-5p sponge to regulate CDKL1 signaling."	0.8466
32779548	"Cell cycle (Georgetown, Tex.)"	2020	Silencing hsa_circRNA_0008035 exerted repressive function on osteosarcoma cell growth and migration by upregulating microRNA-375.	hsa_circ_0008035	hsa_circRNA_0008035 	hsa_circ_EXT1	EXT1	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"hsa_circ_0008035 is up-regulated in serum, tissues and cell lines from osteosarcoma. Functionally, hsa_circ_0008035 promotes OSA cell growth and migration and suppresses apoptosis, while its silencing has antitumor effects. Mechanistically, it acts through miR-375 and the Notch signaling pathway, suggesting potential value as an early diagnostic biomarker or therapeutic target."	0.6521
32783373	The journal of gene medicine	2020	"Protective effects of P2X7R antagonist in sepsis-induced acute lung injury in mice via regulation of circ_0001679 and circ_0001212 and downstream Pln, Cdh2, and Nprl3 expression."	mmu_circ_0001679				sepsis-induced acute lung injury 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR; RNA-seq	"mmu_circ_0001679 was significantly up-regulated in lung tissue from LPS-induced septic ALI mice and reduced by P2X7R antagonist A-438079. The study predicts that mmu_circ_0001679 may act as a ceRNA regulating Nprl3 via miRNA sponging, potentially contributing to sepsis-induced ALI and the protective effect of P2X7R antagonism."	0.5761
32783373	The journal of gene medicine	2020	"Protective effects of P2X7R antagonist in sepsis-induced acute lung injury in mice via regulation of circ_0001679 and circ_0001212 and downstream Pln, Cdh2, and Nprl3 expression."	mmu_circ_0001212	circ_0001212			sepsis-induced acute lung injury 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR; RNA-seq	"mmu_circ_0001212 was significantly up-regulated in lung tissue from LPS-induced septic ALI mice and reduced by P2X7R antagonist A-438079. The study predicts that mmu_circ_0001212 may function through a circRNA-miRNA-mRNA ceRNA network involving Pln, Cdh2 and Nprl3, potentially participating in sepsis-induced ALI and the protective response to P2X7R antagonist treatment."	0.5761
32783691	Cancer biotherapy & radiopharmaceuticals	2022	Serum-Derived Exosomes-Mediated Circular RNA ARHGAP10 Modulates the Progression of Non-Small Cell Lung Cancer Through the miR-638/FAM83F Axis.		circARHGAP10 	hsa_circ_ARHGAP10	ARHGAP10	Non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circARHGAP10 is upregulated in NSCLC tissues, cells, serum, and serum-derived exosomes. It promotes NSCLC proliferation, migration, invasion, glycolysis, and xenograft tumor growth by sponging miR-638 and increasing FAM83F expression, suggesting potential biomarker and therapeutic relevance."	0.7795
32789658	Molecular and cellular biochemistry	2020	"Interference with circBC048201 inhibits the proliferation, migration, and invasion of bladder cancer cells through the miR-1184/ITGA3 axis."		circBC048201 	hsa_circ_BC048201		bladder cancer	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circBC048201 is upregulated in bladder cancer tissues and cell lines. It promotes bladder cancer cell proliferation, migration, and invasion by acting as a miR-1184 sponge and relieving repression of ITGA3, supporting a circBC048201/miR-1184/ITGA3 ceRNA axis as a potential therapeutic target."	0.6772
32790025	EMBO reports	2020	Epstein-Barr virus-derived circular RNA LMP2A induces stemness in EBV-associated gastric cancer.		ebv-circLMP2A 		LMP2A	EBV-associated gastric cancer 	MONDO:0017784	Epstein-Barr virus-associated gastric carcinoma	up-regulated	RT-qPCR; Northern Blot; RNA-seq	"This EBV-derived circRNA is upregulated in EBVaGC stem-like cells and promotes stemness, self-renewal, migration, invasion, metastasis, and drug resistance while inhibiting apoptosis. Mechanistically, it acts as a cytoplasmic sponge for miR-3908 to derepress TRIM59 and suppress p53, forming a ceRNA axis that supports CSC phenotypes and correlates with poor prognosis."	0.8834
32794418	"Cell cycle (Georgetown, Tex.)"	2020	Circular RNA circ-SLC7A6 acts as a tumor suppressor in non-small cell lung cancer through abundantly sponging miR-21.		circ-SLC7A6	hsa_circ_SLC7A6	SLC7A6	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"circ-SLC7A6 is downregulated in NSCLC and low expression is associated with aggressive clinicopathological features and worse survival. Functionally, circ-SLC7A6 suppresses NSCLC proliferation, invasion, tumor growth and lung metastasis by sponging oncogenic miR-21 and increasing multiple miR-21 downstream tumor suppressors. QKI is also implicated in a positive regulatory loop by binding introns flanking circ-SLC7A6 and facilitating its production."	0.8769
32795540	Life sciences	2020	"Hsa_circ_0029589 knockdown inhibits the proliferation, migration and invasion of vascular smooth muscle cells via regulating miR-214-3p and STIM1."	hsa_circ_0029589	circ_0029589 	hsa_circ_CHFR	CHFR	atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"In an in vitro ox-LDL-induced atherosclerosis-like VSMC injury model, hsa_circ_0029589/circ_0029589 was up-regulated. Its knockdown inhibited VSMC proliferation, migration and invasion and promoted apoptosis/cell cycle arrest. Mechanistically, circ_0029589 acted through the miR-214-3p/STIM1 axis, suggesting it may be a therapeutic target for atherosclerosis."	0.6585
32798322	Diabetes/metabolism research and reviews	2021	Circulating circular RNAs profiles associated with type 1 diabetes.	hsa_circ_0072697	circ_0072697		PPWD1	type 1 diabetes 	MONDO:0005147	type 1 diabetes mellitus	down-regulated	RT-qPCR; Microarray	"hsa_circ_0072697 is a downregulated circRNA in the peripheral blood of T1D patients. The study suggests that it may act as a ceRNA/miRNA sponge and participate in diabetes-related circRNA-miRNA-mRNA networks, including the miR-15a-UBASH3A axis, thereby potentially influencing beta-cell function and T1D pathogenesis."	0.2465
32798322	Diabetes/metabolism research and reviews	2021	Circulating circular RNAs profiles associated with type 1 diabetes.	hsa_circ_0002473			DNAJC3	type 1 diabetes 	MONDO:0005147	type 1 diabetes mellitus	up-regulated	RT-qPCR; Microarray	"hsa_circ_0002473 is an upregulated circRNA in T1D peripheral blood that was validated by qRT-PCR. The paper links it to coding potential, but does not establish a diabetes-related ceRNA network or specific downstream mechanism for this circRNA."	0.2465
32798559	Life sciences	2020	Circ_WBSCR17 aggravates inflammatory responses and fibrosis by targeting miR-185-5p/SOX6 regulatory axis in high glucose-induced human kidney tubular cells.	hsa_circ_0080425	circ_WBSCR17 	hsa_circ_WBSCR17	WBSCR17	Diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"Circ_WBSCR17 is up-regulated in streptozotocin-induced DN mouse kidney cortex and high glucose-induced HK-2 cells. It aggravates HG-induced tubular cell injury by suppressing proliferation and promoting apoptosis, inflammatory responses and fibrosis. Mechanistically, circ_WBSCR17 targets miR-185-5p to increase SOX6 expression."	0.627
32799541	Cancer biotherapy & radiopharmaceuticals	2021	"Exosome-Derived Circ-PVT1 Contributes to Cisplatin Resistance by Regulating Autophagy, Invasion, and Apoptosis Via miR-30a-5p/YAP1 Axis in Gastric Cancer Cells."		circRNA-plasmacytoma variant translocation 1 	hsa_circ_PVT1	PVT1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"This study found that exosomal circ-PVT1 is upregulated in cisplatin-resistant gastric cancer serum exosomes and cells. Functionally, circ-PVT1 promotes cisplatin resistance by suppressing miR-30a-5p and indirectly increasing YAP1, thereby enhancing autophagy and invasion while inhibiting apoptosis; circ-PVT1 knockdown improves DDP sensitivity in vitro and in a cell line-derived xenograft model."	0.6536
32799546	DNA and cell biology	2020	"Whole Transcriptome RNA Sequencing Identified circ_022743, circ_052666, and circ_004452 Were Associated with Colon Cancer Development."		circ_022743			colon cancer 	MONDO:0021063	malignant colon neoplasm	down-regulated	RT-qPCR; RNA-seq	"circ_022743 was significantly down-regulated in early- and later-stage colon tumor tissues. The study suggests it may be involved in colon cancer initiation and progression through synergistic expression with SGK1 and regulation of the neurotrophin signaling pathway, and may have biomarker potential."	0.4032
32799546	DNA and cell biology	2020	"Whole Transcriptome RNA Sequencing Identified circ_022743, circ_052666, and circ_004452 Were Associated with Colon Cancer Development."		circ_052666			colon cancer 	MONDO:0021063	malignant colon neoplasm	up-regulated	RT-qPCR; RNA-seq	circ_052666 was markedly up-regulated in colon tumor tissues by qPCR validation. The study identifies a possible hsa-miR-29b/c-3p-circ_052666-COL1A1 ceRNA relationship and suggests that circ_052666 may influence colon cancer development through COL1A1 and ECM-receptor interaction.	0.4032
32799546	DNA and cell biology	2020	"Whole Transcriptome RNA Sequencing Identified circ_022743, circ_052666, and circ_004452 Were Associated with Colon Cancer Development."		circ_004452			colon cancer 	MONDO:0021063	malignant colon neoplasm	down-regulated	RT-qPCR; RNA-seq	circ_004452 was down-regulated specifically in later-stage colon tumor tissues compared with normal colon tissues. The study proposes a hsa-miR-1294-circ_004452-LEFTY1 ceRNA relationship and suggests that circ_004452 may affect later-stage colon cancer progression by altering TGF-b signaling.	0.4032
32800553	Biochemical and biophysical research communications	2020	CircZNF609 is involved in the pathogenesis of focal segmental glomerulosclerosis by sponging miR-615-5p.		circZNF609	hsa_circ_ZNF609	ZNF609	focal segmental glomerulosclerosis 	MONDO:0100313	focal segmental glomerulosclerosis	up-regulated	RT-qPCR; ISH	"circZNF609 is up-regulated in Adriamycin-induced FSGS mouse kidneys, BSA-exposed HK-2 cells, and renal biopsies from FSGS patients. The study suggests that circZNF609 contributes to FSGS pathogenesis through a circZNF609/miR-615-5p/COL1 ceRNA mechanism, promoting podocyte injury and renal fibrosis."	0.4997
32800553	Biochemical and biophysical research communications	2020	CircZNF609 is involved in the pathogenesis of focal segmental glomerulosclerosis by sponging miR-615-5p.		circZNF609	mmu_circ_ZNF609	ZNF609	focal segmental glomerulosclerosis 	MONDO:0100313	focal segmental glomerulosclerosis	up-regulated	RT-qPCR; ISH	"circZNF609 is up-regulated in Adriamycin-induced FSGS mouse kidneys, BSA-exposed HK-2 cells, and renal biopsies from FSGS patients. The study suggests that circZNF609 contributes to FSGS pathogenesis through a circZNF609/miR-615-5p/COL1 ceRNA mechanism, promoting podocyte injury and renal fibrosis."	0.4997
32800940	Molecular and cellular probes	2020	CircHIPK3 regulates melanoma cell behaviors by binding with miR-215-5p to upregulate YY1.	hsa_circ_0000284	circHIPK3 	hsa_circ_HIPK3	HIPK3	melanoma	MONDO:0005105	melanoma	up-regulated	RT-qPCR	"circHIPK3 is upregulated in melanoma tissues and cell lines and appears to act as an oncogenic circRNA. Mechanistically, it sponges miR-215-5p and increases YY1 expression, thereby promoting melanoma cell proliferation and suppressing apoptosis. Its expression correlates positively with Ki-67, suggesting potential relevance to melanoma progression and therapeutic targeting."	0.7945
32803502	Molecular biology reports	2020	A novel circular RNA hsa_circ_0060927 may serve as a potential diagnostic biomarker for human colorectal cancer.	hsa_circ_0060927			CYP24A1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"This study reports that hsa_circ_0060927 is up-regulated in a subset of CRC tissues and is inducible by vitamin D in CRC cell lines. It may function as a ceRNA/miRNA sponge for hsa-miR-224-3p, hsa-miR-522-3p, and hsa-miR-1264, thereby increasing CYP24A1 expression, and it was explored as a potential diagnostic biomarker with limited clinical utility due to low detectability in many samples."	0.6238
32807495	Biochemical and biophysical research communications	2020	circ-ZUFSP regulates trophoblasts migration and invasion through sponging miR-203 to regulate STOX1 expression.		circ-ZUFSP	hsa_circ_ZUFSP	ZUFSP	Recurrent spontaneous abortion 	MONDO:0005047	infertility disorder	down-regulated	RT-qPCR	"circ-ZUFSP is down-regulated in placental tissues of RSA mice. Functionally, circ-ZUFSP promotes trophoblast migration and invasion, while its loss suppresses these processes. Mechanistically, circ-ZUFSP acts through a miR-203/STOX1 axis by sponging miR-203 and increasing STOX1 expression, suggesting potential diagnostic or therapeutic relevance in RSA."	0.6521
32807495	Biochemical and biophysical research communications	2020	circ-ZUFSP regulates trophoblasts migration and invasion through sponging miR-203 to regulate STOX1 expression.		circ-ZUFSP	mmu_circ_ZUFSP	ZUFSP	Recurrent spontaneous abortion 	MONDO:0005047	infertility disorder	down-regulated	RT-qPCR	"circ-ZUFSP is down-regulated in placental tissues of RSA mice. Functionally, circ-ZUFSP promotes trophoblast migration and invasion, while its loss suppresses these processes. Mechanistically, circ-ZUFSP acts through a miR-203/STOX1 axis by sponging miR-203 and increasing STOX1 expression, suggesting potential diagnostic or therapeutic relevance in RSA."	0.6521
32807692	Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver	2020	Circ-SMARCA5 suppresses colorectal cancer progression via downregulating miR-39-3p and upregulating ARID4B.		Circ-SMARCA5 	hsa_circ_SMARCA5	SMARCA5	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"Circ-SMARCA5 is downregulated in colorectal cancer tissues and cell lines, while higher expression is associated with favorable overall survival. Functionally, circ-SMARCA5 acts as a tumor suppressor that inhibits CRC cell proliferation, colony formation, migration, invasion, and xenograft tumor growth. Mechanistically, it functions through a ceRNA-like axis involving miR-39-3p/miR-93-3p and ARID4B upregulation."	0.7412
32808701	Cell biology international	2020	CircIL4R facilitates the tumorigenesis and inhibits ferroptosis in hepatocellular carcinoma by regulating the miR-541-3p/GPX4 axis.	hsa_circ_0038718	circ-interleukin-4 receptor 	hsa_circ_IL4R	IL4R	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"CircIL4R is up-regulated in HCC tissues and cell lines and high expression is associated with poorer overall survival. Functionally, circIL4R promotes HCC proliferation and tumor growth while inhibiting apoptosis and erastin-induced ferroptosis. Mechanistically, it acts as a sponge for miR-541-3p to positively regulate GPX4 expression, forming the circIL4R/miR-541-3p/GPX4 axis."	0.8568
32808744	Cell biology international	2020	Circular RNA PRMT5 confers cisplatin-resistance via miR-4458/REV3L axis in non-small-cell lung cancer.	hsa_circ_0031250	Circular RNA 0031250 	hsa_circ_PRMT5	PRMT5	non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"This study found that circ-PRMT5 is up-regulated in cisplatin-resistant NSCLC tissues and cells. Functionally, circ-PRMT5 promotes DDP resistance, invasion, and tumor growth and inhibits apoptosis by acting as a sponge for miR-4458 to up-regulate REV3L."	0.7177
32810511	Experimental cell research	2020	Hsa_circ_0007494 suppresses prostate cancer progression via miR-616/PTEN axis.	hsa_circ_0007494		hsa_circ_ROCK2	ROCK2	prostate cancer 	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR	"Hsa_circ_0007494 is down-regulated in prostate cancer tissues and cell lines, and low expression is associated with metastasis and advanced tumor stage. Functionally, hsa_circ_0007494 acts as a tumor suppressor by inhibiting PCa cell proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, it sponges miR-616 to upregulate PTEN, forming the hsa_circ_0007494/miR-616/PTEN axis."	0.8032
32822232	Cancer biotherapy & radiopharmaceuticals	2023	Circular RNA cMras Suppresses the Progression of Lung Adenocarcinoma Through ABHD5/ATGL Axis Using NF-kappaB Signaling Pathway.			hsa_circ_Mras	Mras	Lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR	"Circ_cMras is down-regulated in lung adenocarcinoma tissues and cells. Its overexpression suppresses proliferation, migration, invasion and xenograft tumor growth, promotes apoptosis, and acts through positive regulation of the ABHD5/ATGL axis with inhibition of NF-kappaB signaling and increased p53."	0.6278
32822848	The international journal of biochemistry & cell biology	2020	Hsa_circ_0008934 promotes the proliferation and migration of osteosarcoma cells by targeting miR-145-5p to enhance E2F3 expression.	hsa_circ_0008934		hsa_circ_ASAP1	ASAP1	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0008934 is up-regulated in osteosarcoma cell lines and functions as an oncogenic circRNA. It promotes proliferation, cell-cycle progression, migration, invasion, and xenograft tumorigenesis while inhibiting apoptosis, mainly through a hsa_circ_0008934/miR-145-5p/E2F3 ceRNA axis."	0.7982
32825956	"Pathology, research and practice"	2020	Identification of epithelial-mesenchymal transition-related circRNA-miRNA-mRNA ceRNA regulatory network in breast cancer.		hsa_circRNA_002082	hsa_circ_MALAT1	MALAT1	breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_002082 is up-regulated in breast cancer tissues and was retained after RT-qPCR validation. The study proposes that it may act as a ceRNA in an EMT-related circRNA-miRNA-mRNA network, potentially regulating hub genes including CENPF, ZWINT, OIP5, BUB1B and DEPDC1 through predicted miRNA interactions."	0.4997
32825956	"Pathology, research and practice"	2020	Identification of epithelial-mesenchymal transition-related circRNA-miRNA-mRNA ceRNA regulatory network in breast cancer.		hsa_circRNA_400031 	hsa_circ_MINK1	MINK1	breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_400031 is up-regulated in breast cancer tissues and was retained after RT-qPCR validation. The study proposes that it may act as a ceRNA in an EMT-related circRNA-miRNA-mRNA network, with a predicted regulatory module involving hsa-miR-483-5p and KIF4A."	0.4997
32825967	"Pathology, research and practice"	2020	Circ_0000218 plays a carcinogenic role in laryngeal cancer through regulating microRNA-139-3p/Smad3 axis.	hsa_circ_0000218				laryngeal cancer 	MONDO:0002358	laryngeal carcinoma	up-regulated	RT-qPCR	"circ_0000218 is up-regulated in LSCC cells and acts as a pro-tumor circRNA. Silencing circ_0000218 suppresses LSCC cell viability and xenograft tumor growth while promoting apoptosis, mainly through negative regulation of miR-139-3p and the downstream Smad3 axis. The study suggests circ_0000218 as a potential therapeutic target for laryngeal cancer."	0.6253
32827680	Gene	2020	Circ_0010220-mediated miR-503-5p/CDCA4 axis contributes to osteosarcoma progression tumorigenesis.	hsa_circ_0010220		hsa_circ_ARHGEF10L	ARHGEF10L	osteosarcoma	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"circ_0010220 is up-regulated in osteosarcoma cells and acts as an oncogenic circRNA. Its knockdown suppresses proliferation, migration, invasion and xenograft tumor growth, while inducing apoptosis and G1 cell-cycle arrest. Mechanistically, circ_0010220 sponges miR-503-5p to regulate CDCA4 expression, suggesting potential biomarker value in osteosarcoma."	0.6835
32827683	Gene	2020	CircZNF609 aggravates neuropathic pain via miR-22-3p/ENO1 axis in CCI rat models.		circular RNA ZNF609 	rno_circ_ZNF609	ZNF609	neuropathic pain 	MONDO:0021667	neuralgia	up-regulated	RT-qPCR	"circZNF609 is up-regulated in CCI rat spinal cord tissue and promotes neuropathic pain progression. Mechanistically, it sponges miR-22-3p, relieves repression of ENO1, and increases inflammatory factors including TNF-alpha, IL-1, and IL-6; circZNF609 knockdown alleviates mechanical allodynia and thermal hyperalgesia."	0.6716
32828310	Biochemical and biophysical research communications	2020	Downregulation of circEPSTI1 represses the proliferation and invasion of non-small cell lung cancer by inhibiting TRIM24 via miR-1248 upregulation.		circEPSTI1 	hsa_circ_EPSTI1		non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circEPSTI1 is up-regulated in NSCLC tissues and cell lines and functions as an oncogenic circRNA. Its knockdown suppresses NSCLC cell proliferation, colony formation and invasion by increasing miR-1248 and reducing the miR-1248 target TRIM24, defining a circEPSTI1-miR-1248-TRIM24 ceRNA axis."	0.7032
32830397	The journal of gene medicine	2020	Circ-SLC8A1 regulates osteoporosis through blocking the inhibitory effect of miR-516b-5p on AKAP2 expression.		circ-SLC8A1 	hsa_circ_SLC8A1	SLC8A1	osteoporosis	MONDO:0005298	osteoporosis	up-regulated	RT-qPCR	"Circ-SLC8A1 is up-regulated in the OVX osteoporosis model and OVX-derived BMSCs. It promotes osteoporosis-related cellular phenotypes by acting as a cytoplasmic ceRNA that binds miR-516b-5p and increases AKAP2 expression, forming the circ-SLC8A1/miR-516b-5p/AKAP2 regulatory axis."	0.7549
32830578	Human & experimental toxicology	2021	Circular RNA has circ 0001591 promoted cell proliferation and metastasis of human melanoma via ROCK1/PI3K/AKT by targeting miR-431-5p.	hsa_circ_0001591				melanoma 	MONDO:0005105	melanoma	up-regulated	RT-qPCR	"circ 0001591 is up-regulated in serum from melanoma patients, and high expression is associated with poorer OS and DFS. Functionally, circ 0001591 promotes melanoma cell growth, invasion/progression and in vivo tumor growth, while suppressing apoptosis. Mechanistically, it acts through the miR-431-5p/ROCK1/PI3K/AKT signaling axis and may serve as a potential therapeutic target."	0.713
32833501	Cancer biotherapy & radiopharmaceuticals	2021	Knockdown of circHIPK3 Facilitates Temozolomide Sensitivity in Glioma by Regulating Cellular Behaviors Through miR-524-5p/KIF2A-Mediated PI3K/AKT Pathway.		circHIPK3 	hsa_circ_HIPK3	HIPK3	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in TMZ-resistant glioma tissues and cells. Its knockdown increases TMZ sensitivity and apoptosis while inhibiting proliferation, migration, invasion, and metastasis. Mechanistically, circHIPK3 sponges miR-524-5p to regulate KIF2A and activate the PI3K/AKT pathway, supporting its potential therapeutic relevance in TMZ-resistant glioma."	0.7164
32833503	Cancer biotherapy & radiopharmaceuticals	2022	Circ_0011292 Enhances Paclitaxel Resistance in Non-Small Cell Lung Cancer by Regulating miR-379-5p/TRIM65 Axis.	hsa_circ_0011292		hsa_circ_TINAGL1	TINAGL1	Non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0011292 is upregulated in NSCLC tissues and paclitaxel-resistant NSCLC cells. Functional experiments show that circ_0011292 promotes malignant progression and paclitaxel resistance by sponging miR-379-5p and increasing TRIM65 expression, making it a potential therapeutic target for NSCLC chemotherapy resistance."	0.7591
32839935	Molecular and cellular biochemistry	2020	"Circ_0079593 facilitates proliferation, metastasis, glucose metabolism and inhibits apoptosis in melanoma by regulating the miR-516b/GRM3 axis."	hsa_circ_0079593	circ_0079593			melanoma	MONDO:0005105	melanoma	up-regulated	RT-qPCR	"circ_0079593 is upregulated in melanoma tissues and cells. Functionally, circ_0079593 promotes melanoma proliferation, migration, invasion, glucose metabolism and xenograft tumor growth while suppressing apoptosis. Mechanistically, it acts as a sponge for miR-516b to increase GRM3 expression, suggesting therapeutic biomarker potential."	0.7045
32844346	Molecular and cellular biochemistry	2021	Circular RNA has_circ_0000034 accelerates retinoblastoma advancement through the miR-361-3p/ADAM19 axis.	hsa_circ_0000034		hsa_circ_DHDDS	DHDDS	retinoblastoma 	MONDO:0008380	retinoblastoma	up-regulated	RT-qPCR	"In this study, hsa_circ_0000034/circ_0000034 was upregulated in retinoblastoma tissues and cells. Functional experiments showed that circ_0000034 promotes RB cell viability, migration, invasion, EMT, and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ_0000034 acts as a sponge for miR-361-3p and thereby upregulates ADAM19, supporting the circ_0000034/miR-361-3p/ADAM19 axis as a potential therapeutic target in RB."	0.7289
32855541	Cancer gene therapy	2021	circSFMBT1 promotes pancreatic cancer growth and metastasis via targeting miR-330-5p/PAK1 axis.	hsa_circ_0066147	circSFMBT1 	hsa_circ_SFMBT1	SFMBT1	Pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"circSFMBT1 (hsa_circ_0066147) is up-regulated in pancreatic cancer tissues and cell lines. It functions mainly as a cytoplasmic miR-330-5p sponge, relieving miR-330-5p-mediated repression of PAK1 and thereby promoting proliferation, migration, invasion, EMT, tumor growth, and lung metastasis while suppressing apoptosis."	0.8623
32856218	Biotechnology letters	2020	Overexpression of circ_0001445 decelerates hepatocellular carcinoma progression by regulating miR-942-5p/ALX4 axis.	hsa_circ_0001445	circ_0001445 	hsa_circ_SMARCA5	SMARCA5	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"Circ_0001445/circSMARCA5 is down-regulated in HCC tissues and cells and functions as a tumor suppressor. Its overexpression inhibits HCC cell cycle progression, migration, invasion, EMT, glycolysis and xenograft tumor growth, mainly by sponging miR-942-5p to increase ALX4 expression. The study suggests circ_0001445 as a potential therapeutic target for HCC."	0.7032
32857667	"Cell cycle (Georgetown, Tex.)"	2020	Propofol disrupts cell carcinogenesis and aerobic glycolysis by regulating circTADA2A/miR-455-3p/FOXM1 axis in lung cancer.			hsa_circ_TADA2A		lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circTADA2A is up-regulated in lung cancer tissues and cell lines and acts as a pro-tumor circRNA. It sponges miR-455-3p to regulate FOXM1 expression, thereby promoting proliferation, migration, invasion and aerobic glycolysis. Propofol suppresses lung cancer progression by downregulating circTADA2A and inhibiting the circTADA2A/miR-455-3p/FOXM1 axis."	0.7177
32860899	Gene	2021	circ_0037128/miR-17-3p/AKT3 axis promotes the development of diabetic nephropathy.	hsa_circ_0037128				diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"circ_0037128 is up-regulated in diabetic nephropathy and in high-glucose-treated mesangial cells. It promotes mesangial cell proliferation and fibrosis by acting as a ceRNA sponge for miR-17-3p, thereby relieving repression of AKT3 and facilitating DN progression."	0.5992
32860901	Gene	2021	Circ_0005075 targeting miR-151a-3p promotes neuropathic pain in CCI rats via inducing NOTCH2 expression.	rno_circ_0005075				neuropathic pain 	MONDO:0021667	neuralgia	up-regulated	RT-qPCR	"circ_0005075 is up-regulated in CCI rat models of neuropathic pain and functions as a positive regulator of pain behaviors and neuroinflammation. Mechanistically, circ_0005075 targets miR-151a-3p and promotes NOTCH2 expression/signaling; knockdown of circ_0005075 relieves mechanical and thermal hyperalgesia and suppresses inflammatory mediators."	0.6207
32865180	Cancer biomarkers : section A of Disease markers	2020	Circ_0007031 enhances tumor progression and promotes 5-fluorouracil resistance in colorectal cancer through regulating miR-133b/ABCC5 axis.	hsa_circ_0007031				colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0007031 is up-regulated in 5-FU-resistant CRC tissues and cells and is associated with CRC resistance to 5-FU. Functionally, circ_0007031 promotes CRC cell proliferation, migration, invasion, tumor growth, and chemoresistance. Mechanistically, circ_0007031 sponges miR-133b to regulate ABCC5 expression, forming a circ_0007031/miR-133b/ABCC5 axis that contributes to malignant progression and 5-FU resistance."	0.7277
32865182	Cancer biomarkers : section A of Disease markers	2020	Identification of differentially expressed circular RNAs in human nasopharyngeal carcinoma.	hsa_circ_0007637		hsa_circ_CREBBP	CREBBP	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0007637 was identified by RNA-Seq and validated by qRT-PCR as up-regulated in NPC tissues and in HK1 and CNE2 NPC cell lines. The study suggests that hsa_circ_0007637, derived from the CREBBP gene, may serve as a biomarker for NPC and may participate in NPC development through predicted circRNA-miRNA-mRNA ceRNA-related mechanisms."	0.5135
32865704	Neurochemical research	2020	"CircDHDDS/miR-361-3p/WNT3A Axis Promotes the Development of Retinoblastoma by Regulating Proliferation, Cell Cycle, Migration, and Invasion of Retinoblastoma Cells."	hsa_circ_0000034	circDHDDS 	hsa_circ_DHDDS	DHDDS	Retinoblastoma 	MONDO:0008380	retinoblastoma	up-regulated	RT-qPCR	"circDHDDS is up-regulated in retinoblastoma tissues and cells. It promotes RB cell proliferation, migration, invasion, cell cycle progression, stemness-related marker expression, and xenograft tumor growth by sponging miR-361-3p and increasing WNT3A expression."	0.7416
32869935	Pathology international	2020	The circRNA circ_0000291 acts as a sponge of microRNA 326 to regulate E26 transformation-specific sequence-1 expression and promote breast cancer progression.	hsa_circ_0000291	circ_0000291			breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0000291 is upregulated in breast cancer tissues and cell lines and is associated with more aggressive clinicopathological features. Functionally, it promotes BC cell proliferation, migration, invasion, metastasis and EMT. Mechanistically, circ_0000291 sponges miR-326 to increase ETS1 expression, forming a circ_0000291/miR-326/ETS1 oncogenic axis."	0.7537
32878470	American journal of physiology. Gastrointestinal and liver physiology	2020	"hsa_circRNA_001587 upregulates SLC4A4 expression to inhibit migration, invasion, and angiogenesis of pancreatic cancer cells via binding to microRNA-223."		hsa_circRNA_001587 			pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_001587 is down-regulated in pancreatic cancer tissues and cell lines, and lower expression is associated with poorer overall survival and clinicopathological progression. Functionally, it suppresses proliferation, migration, invasion, angiogenesis and xenograft tumor growth by binding miR-223 and relieving miR-223-mediated repression of SLC4A4."	0.8792
32879441	Journal of human genetics	2021	Aberrant expression of a novel circular RNA in pancreatic cancer.		circPDAC RNA			pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; ISH; RNA-seq	"circPDAC RNA is a novel human circRNA derived from chromosome 12 noncoding RNA loci and is significantly up-regulated in PDAC tissues compared with normal pancreas. It is mainly cytoplasmic, detectable in exosome fractions and serum, and may serve as a non-invasive biomarker for PDAC and IPMN. Functional testing suggested that circPDAC RNA retards cell proliferation, while no miRNA-sponge activity or peptide translation was detected."	0.7063
32889056	Gene	2021	Circular RNA HIPK3 exacerbates diabetic nephropathy and promotes proliferation by sponging miR-185.		Circular RNA HIPK3 	mmu_circ_HIPK3	HIPK3	diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in renal tissues of diabetic nephropathy mice and in high-glucose-treated rat mesangial cells. Functionally, circHIPK3 promotes mesangial cell proliferation and DN progression by sponging miR-185 and regulating fibrosis- and proliferation-associated factors including TGF-beta1, Col. I, FN, cyclin D1, and PCNA. The study proposes circHIPK3 as a potential early diagnostic biomarker and therapeutic target for DN."	0.528
32889056	Gene	2021	Circular RNA HIPK3 exacerbates diabetic nephropathy and promotes proliferation by sponging miR-185.		Circular RNA HIPK3 	rno_circ_HIPK3	HIPK3	diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in renal tissues of diabetic nephropathy mice and in high-glucose-treated rat mesangial cells. Functionally, circHIPK3 promotes mesangial cell proliferation and DN progression by sponging miR-185 and regulating fibrosis- and proliferation-associated factors including TGF-beta1, Col. I, FN, cyclin D1, and PCNA. The study proposes circHIPK3 as a potential early diagnostic biomarker and therapeutic target for DN."	0.528
32890417	The journal of gene medicine	2020	Circ_0000144 facilitates the progression of thyroid cancer via the miR-217/AKT3 pathway.	hsa_circ_0000144		hsa_circ_SLAMF6	SLAMF6	thyroid carcinoma 	MONDO:0015075	thyroid gland carcinoma	up-regulated	RT-qPCR	"Circ_0000144 is up-regulated in thyroid carcinoma tissues and cell lines, and its high expression is associated with larger tumor size, advanced TNM stage and lymph node metastasis. Functionally, circ_0000144 promotes TC cell proliferation, migration, invasion and EMT. Mechanistically, it targets miR-217 and up-regulates AKT3 expression, thereby facilitating TC progression through the miR-217/AKT3 pathway."	0.6521
32891769	Gene	2021	"Circ_LARP4 regulates high glucose-induced cell proliferation, apoptosis, and fibrosis in mouse mesangial cells."		circ_LARP4 	mmu_circ_LARP4	LARP4	diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	down-regulated	RT-qPCR	"In a high glucose-induced mouse mesangial cell model of diabetic nephropathy, circ_LARP4 was downregulated. Restoring circ_LARP4 suppressed cell proliferation and fibrotic marker expression while enhancing apoptosis, at least partly through sponging miR-424."	0.414
32891771	Gene	2021	Circular RNA Circ_0000442 acts as a sponge of MiR-148b-3p to suppress breast cancer via PTEN/PI3K/Akt signaling pathway.	hsa_circ_0000442	circ_0000442 	hsa_circ_MED13L	MED13L	breast cancer	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000442/circ_0000442 is down-regulated in breast cancer tissues and cell lines. It acts as a tumor suppressor by sponging miR-148b-3p, thereby relieving miR-148b-3p-mediated repression of PTEN and inhibiting PI3K/Akt signaling, which reduces proliferation, colony formation, and xenograft tumor growth."	0.657
32897735	Cancer biotherapy & radiopharmaceuticals	2023	Circ_SIPA1L1 Promotes Osteosarcoma Progression Via miR-379-5p/MAP3K9 Axis.	hsa_circ_0032462	circ_SIPA1L1 	hsa_circ_SIPA1L1	SIPA1L1	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"Circ_SIPA1L1 is upregulated in osteosarcoma tissues and cell lines. It promotes OS proliferation, migration, invasion, EMT, and xenograft tumor growth by sponging miR-379-5p and increasing MAP3K9 expression, suggesting the circ_SIPA1L1/miR-379-5p/MAP3K9 axis as a potential therapeutic entry point."	0.8001
32897801	"Cell cycle (Georgetown, Tex.)"	2020	Knockdown of circular RNA circMAT2B reduces oxygen-glucose deprivation-induced inflammatory injury in H9c2 cells through up-regulating miR-133.		circMAT2B	rno_circ_MAT2B	MAT2B	Myocardial infarction 	MONDO:0005068	myocardial infarction	up-regulated	RT-qPCR	"In an OGD-induced H9c2 cell model of myocardial infarction-related injury, circMAT2B was up-regulated. Knockdown of circMAT2B protected H9c2 cells by increasing miR-133, reducing apoptosis, ROS production and inflammatory cytokine release, and alleviating inhibition of PI3K/AKT and Raf/MEK/ERK signaling."	0.4236
32900491	Biochemical and biophysical research communications	2020	CircAKT1 acts as a sponge of miR-338-3p to facilitate clear cell renal cell carcinoma progression by up-regulating CAV1.	hsa_circ_0033546	circAKT1	hsa_circ_AKT1	AKT1	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR; Microarray	"circAKT1 is up-regulated in ccRCC tissues and cell lines, and high expression is associated with advanced TNM stage, lymph node metastasis, and poor overall survival. Functionally, circAKT1 promotes proliferation, colony formation, migration, invasion, and EMT in ccRCC cells. Mechanistically, circAKT1 acts as a cytoplasmic sponge for miR-338e3p to release CAV1 from miRNA-mediated repression, thereby facilitating ccRCC progression."	0.8389
32902825	"Cellular oncology (Dordrecht, Netherlands)"	2021	Circular RNA circNFATC3 acts as a miR-9-5p sponge to promote cervical cancer development by upregulating SDC2.	hsa_circ_0005615	CircNFATC3	hsa_circ_NFATC3	NFATc3	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"circNFATC3 (hsa_circ_0005615), derived from NFATC3, is upregulated in cervical cancer tissues and associated with larger tumor size and stromal invasion. It promotes cervical cancer cell proliferation, migration, invasion and xenograft tumor growth by sponging miR-9-5p, thereby upregulating SDC2 and downstream syntenin-1/NF-kappaB/MMP9 signaling. The study proposes circNFATC3 as an oncogenic circRNA and a potential therapeutic target, especially for advanced cervical cancer or LACC."	0.866
32907351	Cancer biotherapy & radiopharmaceuticals	2023	Exosomal circFBLIM1 Promotes Hepatocellular Carcinoma Progression and Glycolysis by Regulating the miR-338/LRP6 Axis.	hsa_circ_0010090	circFBLIM1 	hsa_circ_FBLIM1	FBLIM1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"Exosomal circFBLIM1 is up-regulated in HCC serum exosomes and HCC cells. It promotes HCC cell viability, tumor growth, and glycolysis while suppressing apoptosis, mainly by sponging miR-338 to upregulate LRP6. The circFBLIM1/miR-338/LRP6 axis is proposed as a potential therapeutic target for HCC."	0.7032
32911346	"Pathology, research and practice"	2020	"CircRNA_102179 promotes the proliferation, migration and invasion in non-small cell lung cancer cells by regulating miR-330-5p/HMGB3 axis."	hsa_circ_0007580	circRNA_102179 			non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circRNA_102179/hsa_circ_0007580 is up-regulated in NSCLC tissues and cell lines. It promotes NSCLC cell proliferation, colony formation, migration, invasion, and xenograft tumor growth, mainly by sponging miR-330-5p and positively regulating HMGB3 expression. The study suggests circRNA_102179 may serve as a potential biomarker and therapeutic target for NSCLC."	0.7674
32918278	The Journal of comparative neurology	2021	Novel circular RNA 2960 contributes to secondary damage of spinal cord injury by sponging miRNA-124.		circRNA-2960 			spinal cord injury 	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR; RNA-seq	"circRNA-2960 is a rat circRNA significantly upregulated in spinal cord injury tissues. It interacts with and sponges miRNA-124, thereby suppressing miRNA-124 activity and promoting secondary SCI damage, including inflammation, apoptosis, and poorer functional recovery. Silencing circRNA-2960 improves tissue recovery and may make it a potential diagnostic marker and therapeutic target for SCI."	0.6722
32918539	IUBMB life	2020	CircMMP1 promotes the progression of glioma through miR-433/HMGB3 axis in vitro and in vivo.	hsa_circ_0024108	circRNA matrix metallopeptidase 1 	hsa_circ_MMP1	MMP1	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"CircMMP1 is up-regulated in glioma tissues, glioma cell lines and serum exosomes from glioma patients. It promotes glioma progression by sponging miR-433 and up-regulating HMGB3, thereby enhancing proliferation, migration, invasion and in vivo tumor growth while suppressing apoptosis. Serum exosomal circMMP1 may have diagnostic value and high levels may indicate poor prognosis."	0.7759
32919302	"Pathology, research and practice"	2020	circCRKL suppresses the progression of prostate cancer cells by regulating the miR-141/KLF5 axis.		circCRKL 	hsa_circ_CRKL	CRKL	prostate cancer 	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR	"circCRKL is down-regulated in prostate cancer tissues and cell lines and functions as a tumor suppressor. Mechanistically, circCRKL sponges miR-141 to upregulate KLF5, thereby inhibiting cell cycle progression, migration, invasion, and in vivo tumor growth while promoting apoptosis."	0.7981
32920730	Human cell	2021	Circ-XPR1 promotes osteosarcoma proliferation through regulating the miR-214-5p/DDX5 axis.	hsa_circ_0005909	Circ-XPR1 	hsa_circ_XPR1	XPR1	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"Circ-XPR1/hsa_circ_0005909 is upregulated in osteosarcoma tissues and cell lines and its high expression is associated with poorer overall and disease-free survival. Functionally, Circ-XPR1 promotes osteosarcoma cell proliferation by acting as a sponge for miR-214-5p, thereby regulating DDX5 expression. The study suggests the Circ-XPR1/miR-214-5p/DDX5 axis as a potential therapeutic target in osteosarcoma."	0.8256
32929177	Laboratory investigation; a journal of technical methods and pathology	2021	CircPAN3 ameliorates myocardial ischaemia/reperfusion injury by targeting miR-421/Pink1 axis-mediated autophagy suppression.		circPAN3 	hsa_circ_PAN3 	PAN3	myocardial ischaemia	MONDO:0024643	myocardial disorder	down-regulated	RT-qPCR	"circPAN3 is downregulated in myocardial I/R injury and H/R-treated cardiomyocytes. Its overexpression protects against myocardial injury by sponging miR-421, regulating Pink1, and suppressing autophagy and apoptosis, suggesting the circPAN3/miR-421/Pink1 axis as a potential therapeutic target."	0.627
32929177	Laboratory investigation; a journal of technical methods and pathology	2021	CircPAN3 ameliorates myocardial ischaemia/reperfusion injury by targeting miR-421/Pink1 axis-mediated autophagy suppression.			mmu_circ_Pan3	Pan3	myocardial ischaemia	MONDO:0024643	myocardial disorder	down-regulated	RT-qPCR	"circPAN3 is downregulated in myocardial I/R injury and H/R-treated cardiomyocytes. Its overexpression protects against myocardial injury by sponging miR-421, regulating Pink1, and suppressing autophagy and apoptosis, suggesting the circPAN3/miR-421/Pink1 axis as a potential therapeutic target."	0.627
32931733	Cell	2020	Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output.	hsa_circ_0089762	circRNA SCAR 	hsa_circ_JA760602	JA760602	nonalcoholic steatohepatitis 	MONDO:0007027	metabolic dysfunction-associated steatohepatitis	down-regulated	RT-qPCR; ISH; Microarray	"hsa_circ_0089762/circRNA SCAR is a human mitochondria-localized circRNA downregulated in NAFLD/NASH liver fibroblasts. It binds ATP5B, blocks CypD-mPTP interaction and mPTP opening, thereby reducing mROS output and fibroblast activation; mitochondrial delivery of circRNA SCAR alleviates high fat diet-induced liver fibrosis/metaflammation in mice."	0.8826
32931733	Cell	2020	Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output.	hsa_circ_0008882				nonalcoholic steatohepatitis 	MONDO:0007027	metabolic dysfunction-associated steatohepatitis	down-regulated	RT-qPCR; Microarray	"hsa_circ_0008882 is a human mitochondria-derived circRNA generated from the heavy strand of mitochondrial DNA and downregulated in NASH fibroblasts. Although validated as suppressed in NASH, its overexpression did not significantly reduce cROS in the functional screen, and no detailed mechanism was established."	0.6676
32931733	Cell	2020	Targeting Mitochondria-Located circRNA SCAR Alleviates NASH via Reducing mROS Output.	hsa_circ_0089763				nonalcoholic steatohepatitis 	MONDO:0007027	metabolic dysfunction-associated steatohepatitis	down-regulated	RT-qPCR; Microarray	"hsa_circ_0089763 is a human mitochondria-derived circRNA generated from the light strand of mitochondrial DNA and downregulated in NASH fibroblasts. The paper validates its expression change and mitochondrial localization, but detailed functional testing was not performed because a mitochondria-specific overexpression construct could not be generated."	0.6034
32931883	Cancer letters	2021	CircARHGAP12 promotes nasopharyngeal carcinoma migration and invasion via ezrin-mediated cytoskeletal remodeling.	hsa_circ_0000231	CircARHGAP12 	hsa_circ_ARHGAP12	ARHGAP12	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circARHGAP12 is up-regulated in nasopharyngeal carcinoma tissues and cell lines. It promotes NPC migration, invasion, lung metastasis, EMT-related changes, and cytoskeletal remodeling by directly binding the EZR mRNA 3'UTR and enhancing EZR mRNA stability, thereby activating an EZR/TPM3/RhoA feedback regulatory complex. The study suggests circARHGAP12 may be a potential biomarker and therapeutic target in NPC."	0.8855
32945062	Head & neck	2020	Diagnostic value of exosomal circMYC in radioresistant nasopharyngeal carcinoma.		circMYC 	hsa_circ_MYC	MYC	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"This study identifies circulating serum exosomal circMYC as up-regulated in NPC, especially in radioresistant NPC, and links high circMYC expression to advanced clinical features, recurrence, and poor survival. Functional experiments indicate that circMYC promotes NPC cell proliferation and radioresistance, while circMYC knockdown sensitizes resistant cells to irradiation. Mechanistically, the study suggests a cytoplasmic ceRNA-related model involving miR-20b-5p/let-7e-5p and AGO1/CRY2 based on bioinformatic prediction."	0.7173
32949310	Molecular and cellular biochemistry	2021	Circular RNA circ_HN1 facilitates gastric cancer progression through modulation of the miR-302b-3p/ROCK2 axis.	hsa_circ_0045602	hsa_circHN1_005 	hsa_circ_HN1	HN1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_HN1 is upregulated in gastric cancer tissues and cells and functions as an oncogenic circRNA. It promotes GC progression by sponging miR-302b-3p and upregulating ROCK2, thereby enhancing proliferation, colony formation, cell cycle progression, migration, invasion and tumor growth while suppressing apoptosis. The study suggests circ_HN1 as a potential therapeutic target for gastric cancer."	0.7052
32950105	Molecular therapy : the journal of the American Society of Gene Therapy	2021	TV-circRGPD6 Nanoparticle Suppresses Breast Cancer Stem Cell-Mediated Metastasis via the miR-26b/YAF2 Axis.			hsa_circ_RGPD6	RGPD6	breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Northern Blot; ISH	"circRGPD6 is down-regulated in breast cancer, especially metastatic lesions and BCSCs. Restoring circRGPD6 with TV-circRGPD6 suppresses BCSC stem-like properties, proliferation and metastasis, partly by sponging miR-26b/miR-26b-5p and increasing YAF2 expression, and it synergizes with docetaxel. Clinically, high circRGPD6 expression predicts better DFS and OS in breast cancer patients."	0.8855
32950633	Gene	2021	Quietness of circular RNA circ_0054633 alleviates the inflammation and proliferation in lipopolysaccharides-induced acute lung injury model through NF-kappaB signaling pathway.	mmu_circ_0054633	circ_0054633			acute lung injury 	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR	"circ_0054633 was up-regulated in LPS-induced ALI models in rats and primary murine pulmonary microvascular endothelial cells. Silencing circ_0054633 alleviated lung injury, inflammatory cytokine production, MPVEC proliferation and apoptosis, likely through suppression of NF-kappaB p65/NF-kappaB signaling. The authors propose circ_0054633 as a potential biomarker for ALI diagnosis and therapy."	0.4245
32950919	Placenta	2020	CircSFXN1 regulates the behaviour of trophoblasts and likely mediates preeclampsia.		circRNA-SFXN1 	hsa_circ_SFXN1	SFXN1	Preeclampsia 	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR; Microarray	"CircSFXN1 is up-regulated in PE placentas and appears to promote PE by impairing trophoblast invasion and endothelial angiogenesis. Mechanistically, it directly interacts with sFLT1 and regulates downstream PE-related proteins, including PAPP-A, ENG, HIF1A and PGF. Knockdown of CircSFXN1 alleviated sFLT1-induced hypertension, proteinuria and placental impairment in a pregnant rat model."	0.8314
32954926	"Cell cycle (Georgetown, Tex.)"	2020	Circular RNA hsa_circ_0001649 suppresses the growth of osteosarcoma cells via sponging multiple miRNAs.	hsa_circ_0001649	circ_0001649	hsa_circ_SHPRH		Osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR	"In this study, hsa_circ_0001649/circ_0001649 was down-regulated in osteosarcoma tissues and cell lines. Functional experiments showed that circ_0001649 overexpression suppressed OS cell viability, colony formation and proliferation, promoted apoptosis, and inhibited STAT signaling. Mechanistically, circ_0001649 acted as a sponge for miR-338-5p, miR-647 and miR-942, suggesting a tumor-suppressive role and potential therapeutic relevance in OS."	0.6521
32956704	Experimental cell research	2020	CiRS-7 functions as a ceRNA of RAF-1/PIK3CD to promote metastatic progression of oral squamous cell carcinoma via MAPK/AKT signaling pathways.		ciRS-7 			oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"ciRS-7 is up-regulated in OSCC tissues and OSCC cell lines and acts as an oncogenic circRNA. It promotes proliferation, migration, invasion and xenograft tumor growth by sponging miR-7, thereby increasing RAF-1 and PIK3CD expression and activating MAPK/AKT-associated metastatic signaling."	0.7661
32956844	Genomics	2020	Silencing circular RNA hsa_circ_009755 promotes growth and metastasis of oral squamous cell carcinoma.		hsa_circ_009755			oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_009755 is downregulated in OSCC tissues and cell lines. Functional assays indicate that hsa_circ_009755 suppresses OSCC cell proliferation, migration, invasion and metastasis-related behavior while promoting apoptosis. The study suggests hsa_circ_009755 may serve as a diagnostic biomarker, with predicted interactions with hsa-miR-1184, hsa-miR-383 and hsa-miR-766."	0.6474
32962802	The American journal of the medical sciences	2021	Identification of Key circRNAs in Non-Small Cell Lung Cancer.	hsa_circ_0003028		hsa_circ_FUT8	FUT8	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	Microarray	hsa_circ_0003028 was identified as a differentially expressed circRNA in NSCLC and was significantly up-regulated compared with controls. It also showed diagnostic potential for distinguishing NSCLC patients from healthy individuals based on public datasets.	0.348
32962802	The American journal of the medical sciences	2021	Identification of Key circRNAs in Non-Small Cell Lung Cancer.	hsa_circ_0015278		hsa_circ_KLHL20	KLHL20	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	Microarray	hsa_circ_0015278 was identified as a differentially expressed circRNA in NSCLC and was significantly down-regulated compared with controls. It also showed diagnostic potential for distinguishing NSCLC patients from healthy individuals based on public datasets.	0.348
32962802	The American journal of the medical sciences	2021	Identification of Key circRNAs in Non-Small Cell Lung Cancer.	hsa_circ_0043256	hsa_-circ_0043256	hsa_circ_ACACA	ACACA	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	Microarray	"hsa_circ_0043256 was identified as a differentially expressed circRNA in NSCLC and was significantly down-regulated compared with controls. The discussion also cites prior work suggesting a circ_0043256/miR-1252/ITCH axis that promotes apoptosis, and the circRNA showed diagnostic potential in public datasets."	0.348
32962802	The American journal of the medical sciences	2021	Identification of Key circRNAs in Non-Small Cell Lung Cancer.	hsa_circ_0049657		hsa_circ_NFIX	NFIX	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	Microarray	hsa_circ_0049657 was identified as a differentially expressed circRNA in NSCLC and was significantly down-regulated compared with controls. It also showed diagnostic potential for distinguishing NSCLC patients from healthy individuals based on public datasets.	0.348
32962802	The American journal of the medical sciences	2021	Identification of Key circRNAs in Non-Small Cell Lung Cancer.	hsa_circ_0074930	hsa_-circ_0074930	hsa_circ_SLIT3	SLIT3	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	Microarray	hsa_circ_0074930 was identified as a differentially expressed circRNA in NSCLC and was significantly down-regulated compared with controls. It also showed diagnostic potential for distinguishing NSCLC patients from healthy individuals based on public datasets.	0.348
32970285	Molecular and cellular biochemistry	2021	"CircZNF609 promotes cell proliferation, migration, invasion, and glycolysis in nasopharyngeal carcinoma through regulating HRAS via miR-338-3p."		Circular RNA zinc finger protein 609 	hsa_circ_ZNF609	ZNF609	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"circZNF609 is up-regulated in NPC tissues and cell lines, and high expression is associated with poor overall survival. Functionally, circZNF609 promotes NPC cell proliferation, migration, invasion, glycolysis, and xenograft tumor growth. Mechanistically, it acts as a ceRNA that sponges miR-338-3p to increase HRAS expression."	0.8174
32970816	Journal of biochemistry	2021	Upregulation of circ_0000142 promotes multiple myeloma progression by adsorbing miR-610 and upregulating AKT3 expression.	hsa_circ_0000142	circ_0000142 	hsa_circ_CCT3	CCT3	multiple myeloma 	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR	"circ_0000142 is up-regulated in multiple myeloma tissues and cell lines and is associated with more advanced ISS and Durie-Salmon stage. Functionally, it promotes MM cell proliferation, migration and invasion while inhibiting apoptosis. Mechanistically, circ_0000142 acts as a ceRNA that sponges miR-610 and increases AKT3 expression, thereby promoting MM progression."	0.7032
32976932	Cellular signalling	2020	Circular RNA expression profiling identifies novel biomarkers in uterine leiomyoma.	hsa_circ_0083920				uterine leiomyoma 	MONDO:0007886	uterine corpus leiomyoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0083920 was significantly up-regulated in uterine leiomyoma tissues and validated by qRT-PCR. ROC analysis suggested that its expression could distinguish ULM tissues from adjacent normal myometrium, indicating potential diagnostic biomarker value."	0.5047
32976932	Cellular signalling	2020	Circular RNA expression profiling identifies novel biomarkers in uterine leiomyoma.	hsa_circ_0056686		hsa_circ_KIF5C	KIF5C	uterine leiomyoma 	MONDO:0007886	uterine corpus leiomyoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0056686 is an up-regulated circRNA in uterine leiomyoma derived from the KIF5C gene. It showed diagnostic potential, was positively associated with leiomyoma size, and knockdown experiments in primary ULM cells suppressed proliferation and spheroid formation, supporting a pro-growth role."	0.6368
32976932	Cellular signalling	2020	Circular RNA expression profiling identifies novel biomarkers in uterine leiomyoma.	hsa_circ_0062558				uterine leiomyoma 	MONDO:0007886	uterine corpus leiomyoma	up-regulated	RT-qPCR; Microarray	hsa_circ_0062558 was significantly up-regulated in ULM tissues and validated by qRT-PCR. ROC analysis indicated potential diagnostic value for distinguishing ULM from normal myometrium.	0.5047
32976932	Cellular signalling	2020	Circular RNA expression profiling identifies novel biomarkers in uterine leiomyoma.	hsa_circ_0020376				uterine leiomyoma 	MONDO:0007886	uterine corpus leiomyoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0020376 was significantly up-regulated in ULM tissues and validated by qRT-PCR. It showed the highest reported ROC AUC among the listed diagnostic circRNAs, suggesting strong potential as a tissue biomarker for ULM."	0.5047
32976932	Cellular signalling	2020	Circular RNA expression profiling identifies novel biomarkers in uterine leiomyoma.	hsa_circ_0043597				uterine leiomyoma 	MONDO:0007886	uterine corpus leiomyoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0043597 was significantly down-regulated in ULM tissues and validated by qRT-PCR. ROC analysis indicated that it could distinguish ULM tissues from normal myometrium, suggesting diagnostic biomarker potential."	0.5047
32976932	Cellular signalling	2020	Circular RNA expression profiling identifies novel biomarkers in uterine leiomyoma.	hsa_circ_0026353				uterine leiomyoma 	MONDO:0007886	uterine corpus leiomyoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0026353 was significantly down-regulated in ULM tissues and validated by qRT-PCR. Unlike the other ROC-positive candidates, it had a low AUC and was reported as unable to accurately distinguish ULM from normal myometrium, though its differential expression was statistically significant."	0.5047
32977948	Biochemical and biophysical research communications	2020	Knockdown of circ_HIPK3 inhibits tumorigenesis of hepatocellular carcinoma via the miR-582-3p/DLX2 axis.		circRNA homeodomain-interacting protein kinase 3 	hsa_circ_HIPK3	HIPK3	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"In this study, circ_HIPK3 is up-regulated in HCC tissues and HCC cell lines. Functional experiments indicate that circ_HIPK3 promotes HCC cell proliferation, migration, invasion, metastasis and in vivo tumor growth while suppressing apoptosis. Mechanistically, circ_HIPK3 acts as a ceRNA for miR-582-3p to increase DLX2 expression, suggesting potential value as a biomarker or therapeutic target for HCC treatment."	0.7595
32978798	Annals of the New York Academy of Sciences	2021	CircCDK8 regulates osteogenic differentiation and apoptosis of PDLSCs by inducing ER stress/autophagy during hypoxia.	hsa_circ_0003489	circCDK8 	hsa_circ_CDK8	CDK8	periodontitis 	MONDO:0005076	periodontitis	up-regulated	RT-qPCR	"This study identifies hsa_circ_0003489/circCDK8 as an up-regulated circRNA in periodontitis tissues and in CoCl2-induced hypoxic PDLSCs. Functionally, circCDK8 promotes ER stress/autophagy and apoptosis through mTOR signaling, thereby repressing osteogenic differentiation of PDLSCs under hypoxia. Silencing circCDK8 reverses hypoxia-induced inhibition of osteogenesis, suggesting circCDK8 as a potential therapeutic target for periodontitis."	0.5732
32980988	Human cell	2021	Knockdown of hsa_circ_0037658 inhibits the progression of osteoarthritis via inducing autophagy.	hsa_circ_0037658	hsa_ circ_0037658			Osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"This study found that hsa_circ_0037658 is up-regulated in IL-1beta-treated CHON-001 osteoarthritis model cells. Silencing hsa_circ_0037658 protects chondrocytes from IL-1beta-induced injury, inhibits apoptosis and inflammation, induces autophagy through autophagy-related proteins, and alleviates OA symptoms in a rat surgical OA model. The authors propose hsa_circ_0037658 as a potential therapeutic target for OA."	0.5446
32985287	Scandinavian journal of clinical and laboratory investigation	2020	"Circular RNA PRKCI and microRNA-545 relate to sepsis risk, disease severity and 28-day mortality."		circular RNA protein kinase C iota 	hsa_circ_PRKCI	PRKCI	sepsis	MONDO:0005229	bacterial infectious disease with sepsis	down-regulated	RT-qPCR	"This clinical study found that plasma circ-PRKCI is down-regulated in sepsis patients compared with healthy controls. Lower circ-PRKCI is associated with higher disease severity and death within 28 days, while higher circ-PRKCI independently predicts decreased 28-day mortality risk. circ-PRKCI is negatively correlated with miR-545, suggesting a possible circ-PRKCI/miR-545 relationship in sepsis."	0.5727
32991963	Genomics	2021	Identification of aberrantly expressed circular RNAs in hyperlipidemia-induced retinal vascular dysfunction in mice.	mmu_circ_0007849		mmu_circ_LDB1	LDB1	hyperlipidemia-induced retinal vascular dysfunction 	MONDO:0002311	retinal vascular disorder	up-regulated	Microarray	"mmu_circ_0007849 was identified as significantly up-regulated in hyperlipidemic mouse retinas. Its individual mechanism was not experimentally characterized in the mouse model, but it was linked to a human homolog later studied as circLDB1."	0.4375
32991963	Genomics	2021	Identification of aberrantly expressed circular RNAs in hyperlipidemia-induced retinal vascular dysfunction in mice.	hsa_circ_0019668		hsa_circ_LDB1	LDB1	coronary artery disease 	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR	"Human circLDB1 (hsa_circ_0019668) was elevated in CAD serum and wet AMD aqueous humor and showed diagnostic potential by ROC analysis. Functionally, circLDB1 supported endothelial cell viability and proliferation and reduced stress-induced apoptosis, suggesting a protective role in hyperlipidemia-related vascular dysfunction."	0.6987
32997362	Cell biology international	2021	Restoration of circPSMC3 sensitizes gefitinib-resistant esophageal squamous cell carcinoma cells to gefitinib by regulating miR-10a-5p/PTEN axis.		circPSMC3	hsa_circ_PSMC3	PSMC3	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	RT-qPCR	"circPSMC3 is downregulated in ESCC tissues, ESCC cell lines, and gefitinib-resistant ESCC cells. Restoring circPSMC3 suppresses proliferation, promotes apoptosis, and sensitizes resistant ESCC cells to gefitinib through the miR-10a-5p/PTEN axis, suggesting therapeutic potential for overcoming gefitinib resistance."	0.7244
33000435	Neurochemical research	2020	Circ-CUX1 Accelerates the Progression of Neuroblastoma via miR-16-5p/DMRT2 Axis.	hsa_circ_0132813	circ-CUX1 	hsa_circ_CUX1	CUX1	neuroblastoma 	MONDO:0005072	neuroblastoma	up-regulated	RT-qPCR	"This study identifies circ-CUX1/hsa_circ_0132813 as an up-regulated oncogenic circRNA in neuroblastoma tissues and cell lines. Circ-CUX1 promotes NB cell proliferation, cell cycle progression, colony formation, migration, invasion, glycolysis and xenograft tumor growth by sponging miR-16-5p and thereby up-regulating DMRT2. High circ-CUX1 expression is associated with shorter survival and more aggressive clinicopathological features."	0.8711
33006200	Experimental physiology	2020	hsa_circ_001653 up-regulates NR6A1 expression and elicits gastric cancer progression by binding to microRNA-377.		hsa_circ_001653 			gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_001653 is up-regulated in gastric cancer tissues and cell lines and is associated with more aggressive clinicopathological features. Functionally, it promotes gastric cancer cell proliferation, migration, invasion and xenograft tumor growth while inhibiting apoptosis. Mechanistically, cytoplasmic hsa_circ_001653 binds miR-377 and increases NR6A1 expression, forming a hsa_circ_001653/miR-377/NR6A1 regulatory axis."	0.742
33006481	Cancer biotherapy & radiopharmaceuticals	2022	CircEXOC6B Suppresses the Proliferation and Motility and Sensitizes Ovarian Cancer Cells to Paclitaxel Through miR-376c-3p/FOXO3 Axis.		circRNA exocyst complex component 6B (circEXOC6B) 	hsa_circ_EXOC6B	EXOC6B	ovarian cancer	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR	"CircEXOC6B is down-regulated in ovarian cancer tissues and cells, and low expression is associated with malignant clinicopathological features and shorter survival. Functionally, circEXOC6B inhibits ovarian cancer cell proliferation, migration, invasion, and paclitaxel resistance while enhancing paclitaxel sensitivity. Mechanistically, circEXOC6B mainly localizes in the cytoplasm and acts through the miR-376c-3p/FOXO3 axis."	0.798
33008587	Biochemical and biophysical research communications	2020	CircRNA circ-0038718 promotes hepatocellular carcinoma progression through sponging miR-139-3p.		hsa-circ-0038718 	hsa_circ_IL4R	IL4R	Hepatocellular Carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circ-0038718 is an IL4R-derived human circRNA upregulated in HCC tissues and cell lines. It acts as an oncogenic circRNA that promotes HCC proliferation, migration, invasion and xenograft tumor growth, at least partly by sponging miR-139-3p and increasing Wnt5a, ELK1 and ANXA2R expression. High circ-0038718 expression is associated with malignant clinicopathologic features and poor OS/DFS, suggesting prognostic and therapeutic relevance."	0.8823
33010282	Life sciences	2020	Circ_0010729 regulates hypoxia-induced cardiomyocyte injuries by activating TRAF5 via sponging miR-27a-3p.	hsa_circ_0010729	circ_0010729	hsa_circ_HSPG2	HSPG2	ischemic heart disease 	MONDO:0024644	myocardial ischemia	up-regulated	RT-qPCR	"circ_0010729 is up-regulated in hypoxia-induced human AC16 cardiomyocytes and aggravates hypoxia-induced cell injury. Mechanistically, circ_0010729 sponges miR-27a-3p to activate TRAF5, thereby reducing cell viability and glycolysis while promoting apoptosis and necrosis. Knockdown of circ_0010729 protects cardiomyocytes from hypoxia-induced injury through the miR-27a-3p/TRAF5 axis."	0.7164
33016781	Cancer biotherapy & radiopharmaceuticals	2022	Puerarin Inhibits the Progression of Bladder Cancer by Regulating circ_0020394/miR-328-3p/NRBP1 Axis.	hsa_circ_0020394		hsa_circ_DOCK1	DOCK1	bladder cancer	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"This study identifies circ_0020394 as a pro-tumor circRNA in bladder cancer cells that counteracts puerarin-induced suppression of viability, migration, invasion and glycolysis and puerarin-induced apoptosis. Mechanistically, circ_0020394 sponges miR-328-3p to increase NRBP1 expression, forming a circ_0020394/miR-328-3p/NRBP1 axis involved in the antitumor response to puerarin."	0.5627
33021399	Cancer biotherapy & radiopharmaceuticals	2023	"Circ_0004913 Inhibits Cell Growth, Metastasis, and Glycolysis by Absorbing miR-184 to Regulate HAMP in Hepatocellular Carcinoma."	hsa_circ_0004913	circ_0004913			hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"Circ_0004913 is downregulated in HCC tissues and cell lines and functions as an antitumor circRNA. It suppresses HCC proliferation, migration, invasion, EMT, glycolysis, and xenograft tumor growth by sponging miR-184, increasing HAMP expression, and inactivating the JAK2/STAT3/AKT pathway."	0.7519
33023375	"Cell cycle (Georgetown, Tex.)"	2020	"Circular RNA circABCC4 acts as a ceRNA of miR-154-5p to improve cell viability, migration and invasion of breast cancer cells in vitro."	hsa_circ_0030586	CircABCC4	hsa_circ_ABCC4	ABCC4	breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circABCC4 is up-regulated in breast cancer tissues and acts as a tumor-promoting circRNA in vitro. Its knockdown suppresses breast cancer cell viability, migration and invasion while promoting apoptosis, at least partly through up-regulating miR-154-5p and inhibiting NF-kappaB and Wnt/beta-catenin signaling pathways."	0.5732
33027196	Journal of cardiovascular pharmacology	2020	Circ-HIPK2 Accelerates Cell Apoptosis and Autophagy in Myocardial Oxidative Injury by Sponging miR-485-5p and Targeting ATG101.		circular RNA HIPK2 	mmu_circ_HIPK2	HIPK2	myocardial injury 	MONDO:0024643	myocardial disorder	up-regulated	RT-qPCR	"In this in vitro H 2 O 2 -induced myocardial oxidative injury model, circ-HIPK2 was up-regulated in mouse neonatal cardiomyocytes. It promotes autophagy, apoptosis, and cell death by sponging miR-485-5p and increasing ATG101 expression, suggesting circ-HIPK2 as a potential therapeutic target for myocardial injury."	0.6959
33031827	Life sciences	2020	CircRNA ITCH increases bortezomib sensitivity through regulating the miR-615-3p/PRKCD axis in multiple myeloma.		CircRNA ITCH 	hsa_circ_ITCH		multiple myeloma 	MONDO:0009693	plasma cell myeloma	down-regulated	RT-qPCR	"circITCH is downregulated in multiple myeloma bone marrow specimens, MM cell lines, and bortezomib-resistant MM cells. Higher circITCH expression predicts longer overall survival, and circITCH overexpression enhances bortezomib sensitivity by promoting apoptosis and suppressing viability through the miR-615-3p/PRKCD axis."	0.7537
33034848	"Cellular oncology (Dordrecht, Netherlands)"	2021	"Circular RNA circ-102,166 acts as a sponge of miR-182 and miR-184 to suppress hepatocellular carcinoma proliferation and invasion."		"circ-102,166"	hsa_circ_TEX2	TEX2	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"circ-102,166 is a TEX2-derived human circRNA that is significantly down-regulated in HCC tissues and cell lines. It functions as a tumor suppressor by sponging miR-182 and miR-184, thereby modulating FOXO3a, MTSS1, SOX7, p-RB and c-MYC and inhibiting HCC proliferation, invasion, migration and tumorigenicity. Clinically, low circ-102,166 expression is associated with aggressive clinicopathologic features and poorer OS/RFS, suggesting biomarker and therapeutic-target potential."	0.8892
33037617	Journal of cellular physiology	2021	Circular RNA CircCDH13 contributes to the pathogenesis of osteoarthritis via CircCDH13/miR-296-3p/PTEN axis.	hsa_circ_0040646	CircCDH13	hsa_circ_CDH13	CDH13	osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; Microarray	"CircCDH13 is up-regulated in human OA cartilage and in IL-1beta/TNF-alpha-treated human chondrocytes. It promotes OA-related chondrocyte apoptosis and ECM catabolism by sponging miR-296-3p and regulating PTEN, while CircCDH13 silencing alleviates DMM-induced OA pathology in mice."	0.866
33040214	Digestive diseases and sciences	2021	Circ_0091581 Promotes the Progression of Hepatocellular Carcinoma Through Targeting miR-591/FOSL2 Axis.	hsa_circ_0091581	circ_0091581	hsa_circ_GPC3		hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"Circ_0091581 is up-regulated in HCC tissues and cell lines and functions as an oncogenic circRNA. It promotes HCC cell viability, colony formation, migration, invasion, cell-cycle progression, and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ_0091581 sponges miR-591 to relieve repression of FOSL2, forming a circ_0091581/miR-591/FOSL2 regulatory axis."	0.7053
33053498	"Pathology, research and practice"	2020	Circular RNA 0086996 regulates growth and migration of osteosarcoma cells via miR-125b-5p.	hsa_circ_0086996	Circular RNA 0086996 	hsa_circ_RECK	RECK	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"hsa_circ_0086996/Circ_0086996 is up-regulated in osteosarcoma tissues and cell lines. It functions as an oncogenic circRNA by sponging miR-125b-5p, thereby promoting proliferation, migration, invasion and cell cycle progression while inhibiting apoptosis. The study suggests Circ_0086996 may serve as a potential biomarker and therapeutic target for osteosarcoma."	0.6536
33054543	"Cell cycle (Georgetown, Tex.)"	2020	"Circular RNA hsa_circ_0001785 inhibits the proliferation, migration and invasion of breast cancer cells in vitro and in vivo by sponging miR-942 to upregulate SOCS3."	hsa_circ_0001785	circ_0001785 			breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	"hsa_circ_0001785 is down-regulated in breast cancer cells. Its overexpression suppresses breast cancer cell proliferation, migration, invasion, and xenograft tumor growth by acting as a ceRNA for miR-942, thereby upregulating SOCS3. The study proposes circ_0001785 as a potential biomarker and therapeutic target for breast cancer."	0.6276
33058028	Human cell	2021	circRNA circ-MYBL2 is a novel tumor suppressor and potential biomarker in multiple myeloma.		circ-MYBL2	hsa_circ_MYBL2	MYBL2	multiple myeloma 	MONDO:0009693	plasma cell myeloma	down-regulated	RT-qPCR	"circ-MYBL2 is down-regulated in MM tissues and serum and acts as a tumor suppressor. It inhibits MM cell proliferation and cell cycle progression by binding Cyclin F and enhancing Cyclin F interaction with MYBL2, leading to reduced MYBL2 phosphorylation and decreased transcription of proliferation-related targets. Clinically, low circ-MYBL2 is associated with advanced stage and poorer survival, while serum circ-MYBL2 shows diagnostic potential."	0.8679
33068224	Neurochemical research	2020	CircCPA4 Promotes the Malignant Phenotypes in Glioma via miR-760/MEF2D Axis.		Circular RNA carboxypeptidase A4 	hsa_circ_CPA4	CPA4	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"CircCPA4 is up-regulated in glioma tissues and cell lines and high expression is associated with higher WHO grade, larger tumor size, and shorter overall survival. Functionally, circCPA4 promotes glioma proliferation, migration, invasion, tumor growth, and radioresistance while suppressing apoptosis. Mechanistically, it acts as a ceRNA for miR-760 to regulate MEF2D, forming a circCPA4/miR-760/MEF2D axis that drives glioma progression."	0.8298
33070258	Journal of bone and mineral metabolism	2021	CircRNA TGFBR2/MiR-25-3p/TWIST1 axis regulates osteoblast differentiation of human aortic valve interstitial cells.		circRNA TGFBR2 	hsa_circ_TGFBR2	TGFBR2	Calcified aortic valve disease 	MONDO:0003803	aortic valve disorder	down-regulated	RT-qPCR	"In CAVD, circRNA TGFBR2 is down-regulated in calcific aortic valves and osteogenically induced human VICs. The study shows that TGFBR2 functions as a miR-25-3p sponge to regulate TWIST1, thereby suppressing osteoblast differentiation, ALP activity, calcified nodule formation, and RUNX2/OPN expression."	0.6102
33080410	Differentiation; research in biological diversity	2020	The involvement of hsa_circ_0000417 in the development of hypospadias by regulating AR.	hsa_circ_0000417		hsa_circ_CPSF6	CPSF6	congenital hypospadias 	MONDO:0019848	posterior hypospadias	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000417 was identified by RNA sequencing and validated by qRT-PCR as significantly downregulated in hypospadias tissues compared with normal foreskin tissues. Its expression correlates with AR expression and clinical features including other diseases and proximal/distal hypospadias site. The authors propose that hsa_circ_0000417 may participate in hypospadias development through a ceRNA mechanism involving hsa-miR-6756-5p-mediated regulation of AR, although this mechanism remains computationally inferred rather than experimentally proven."	0.6193
33084863	Journal of biochemistry	2021	Circular RNA hsa_circ_0102231 sponges miR-145 to promote non-small cell lung cancer cell proliferation by up-regulating the expression of RBBP4.	hsa_circ_0102231				non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0102231 is up-regulated in NSCLC cell lines and mainly localized in the cytoplasm. It promotes NSCLC cell proliferation and invasion by sponging miR-145 and thereby increasing RBBP4 expression, suggesting potential therapeutic relevance."	0.7296
33085761	Acta biochimica et biophysica Sinica	2020	Circular RNA SMARCA5 suppressed non-small cell lung cancer progression by regulating miR-670-5p/RBM24 axis.		circular RNA SMARCA5 	hsa_circ_SMARCA5	SMARCA5	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; ISH	"circsSMARCA5 is down-regulated in NSCLC tissues and cell lines, and low expression is associated with larger tumor size, advanced TNM stage, and poor overall survival. Functionally, circsSMARCA5 suppresses NSCLC tumor growth and cell proliferation while promoting apoptosis. Mechanistically, it acts as a sponge for miR-670-5p and upregulates RBM24, forming a circsSMARCA5/miR-670-5p/RBM24 suppressive axis."	0.8069
33089757	"Cell cycle (Georgetown, Tex.)"	2020	Circular RNA MTO1 inhibits gastric cancer progression by elevating PAWR via sponging miR-199a-3p.		circular RNA MTO1 	hsa_circ_MTO1	MTO1	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"circMTO1 is down-regulated in gastric cancer tissues and cell lines, and low circMTO1 expression is associated with poor overall survival and aggressive clinicopathological features. Functionally, circMTO1 suppresses gastric cancer proliferation, migration, invasion, metastasis and tumor growth while promoting apoptosis. Mechanistically, circMTO1 sponges miR-199a-3p to elevate PAWR expression, thereby inhibiting gastric cancer progression through the circMTO1/miR-199a-3p/PAWR axis."	0.7982
33090006	Cancer biotherapy & radiopharmaceuticals	2020	Identification of circ_0085616 as an Upregulated and Oncogenic Circular RNA in Cervical Cancer Via the miR-503-5p-Mediated ATXN7L3 Activation.	hsa_circ_0085616	CircRNA_0085616 			cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ_0085616 is up-regulated in cervical cancer tissues and cell lines. It promotes proliferation, migration, invasion, glycolysis, and in vivo tumor growth by sponging miR-503-5p and activating ATXN7L3, suggesting potential diagnostic and therapeutic relevance."	0.7045
33090019	Epigenomics	2020	Circular RNA expression profiling and bioinformatic analysis of cumulus cells in endometriosis infertility patients.	hsa_circ_0072391		hsa_circ_HMGCS1	HMGCS1	endometriosis-associated infertility 	MONDO:0005047	infertility disorder	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0072391 was up-regulated in cumulus cells from endometriosis-associated infertility patients and validated by qRT-PCR. The study predicts that it may regulate cumulus cell proliferation and apoptosis through ceRNA axes involving let-7g-5p/TGFBR1 or miR-129-5p/HMGB1.	0.5994
33090019	Epigenomics	2020	Circular RNA expression profiling and bioinformatic analysis of cumulus cells in endometriosis infertility patients.	hsa_circ_0007299		hsa_circ_CYP51A1	CYP51A1	endometriosis-associated infertility 	MONDO:0005047	infertility disorder	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0007299 was up-regulated in cumulus cells from endometriosis-associated infertility patients and validated by qRT-PCR. It is spliced from CYP51A1 and may regulate CYP51A1 expression and follicular development, with miR-3926 predicted as a target miRNA."	0.5994
33090019	Epigenomics	2020	Circular RNA expression profiling and bioinformatic analysis of cumulus cells in endometriosis infertility patients.	hsa_circ_0057799		hsa_circ_BMPR2	BMPR2	endometriosis-associated infertility 	MONDO:0005047	infertility disorder	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0057799 was up-regulated in cumulus cells from endometriosis-associated infertility patients and validated by qRT-PCR. It is spliced from BMPR2 and was included in the predicted circRNA-miRNA-mRNA ceRNA network, suggesting a potential role in abnormal follicular development."	0.5994
33090019	Epigenomics	2020	Circular RNA expression profiling and bioinformatic analysis of cumulus cells in endometriosis infertility patients.		hsa circ 001533 	hsa_circ_FKBP5	FKBP5	endometriosis-associated infertility 	MONDO:0005047	infertility disorder	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_001533 was down-regulated in cumulus cells from endometriosis-associated infertility patients and validated by qRT-PCR. It is spliced from FKBP5 and may affect cumulus cell apoptosis and oocyte nuclear maturation through regulation of FKBP51/FKBP5, and was included in a predicted ceRNA network."	0.5994
33090893	"Cell cycle (Georgetown, Tex.)"	2020	Circular RNA-DENND4C in H9c2 cells relieves OGD/R-induced injury by down regulation of microRNA-320.	hsa_circ_0005684	circRNA-DENND4C 	hsa_circ_DENND4C	DENND4C	Ischemic heart disease 	MONDO:0024644	myocardial ischemia	up-regulated	RT-qPCR	"In an H9c2 OGD/R model of ischemic injury, circRNA-DENND4C was up-regulated and functioned protectively by promoting cell viability and suppressing apoptosis. Mechanistically, circRNA-DENND4C directly sponged miR-320 and activated ERK and mTOR signaling, thereby attenuating OGD/R-induced damage."	0.5223
33091396	Experimental and molecular pathology	2020	Circ-XPO1 upregulates XPO1 expression by sponging multiple miRNAs to facilitate osteosarcoma cell progression.		hsa_circRNA_102736 	hsa_circ_XPO1	XPO1	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"Circ-XPO1 is up-regulated in osteosarcoma tissues and cells and high expression predicts poor overall survival. It promotes OS cell viability, colony formation and invasion while inhibiting apoptosis, acting mainly as a cytoplasmic ceRNA that sponges miR-23a-3p, miR-23b-3p, miR-23c and miR-130a-5p to increase XPO1 expression."	0.8625
33091396	Experimental and molecular pathology	2020	Circ-XPO1 upregulates XPO1 expression by sponging multiple miRNAs to facilitate osteosarcoma cell progression.		hsa_circRNA_102069			osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	hsa_circRNA_102069 was identified as up-regulated in osteosarcoma specimens compared with paired neighboring normal tissues during preliminary circRNA profiling and qRT-PCR validation. No functional mechanism or clinical prognostic role was reported for this circRNA.	0.3588
33091396	Experimental and molecular pathology	2020	Circ-XPO1 upregulates XPO1 expression by sponging multiple miRNAs to facilitate osteosarcoma cell progression.		hsa_circRNA_100571			osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"hsa_-circRNA_100571 was found to be up-regulated in osteosarcoma specimens compared with paired neighboring normal tissues during preliminary circRNA expression validation. The study did not further characterize its mechanism, function, or clinical significance."	0.3588
33091396	Experimental and molecular pathology	2020	Circ-XPO1 upregulates XPO1 expression by sponging multiple miRNAs to facilitate osteosarcoma cell progression.		hsa_circRNA_101850			osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_101850 was reported to be up-regulated in osteosarcoma specimens compared with paired neighboring normal tissues in the preliminary expression analysis. No downstream mechanism, biological function, or prognostic association was investigated for this circRNA."	0.3588
33095438	Neurochemical research	2020	Circular RNA Circ_ANKMY2 Regulates Temporal Lobe Epilepsy Progression via the miR-106b-5p/FOXP1 Axis.		circ_ ANKMY2 	hsa_circ_ANKMY2	ANKMY2	Temporal lobe epilepsy 	MONDO:0005115	temporal lobe epilepsy	down-regulated	RT-qPCR	"circ_ANKMY2 is down-regulated in TLE tissues and SK-N-AS cells. Its overexpression suppresses SK-N-AS cell colony formation and proliferation, promotes apoptosis, and reduces spontaneous recurrent seizures in a kainic acid-induced rat TLE model. Mechanistically, circ_ANKMY2 functions as a miR-106b-5p sponge to up-regulate FOXP1, suggesting a potential therapeutic role in TLE."	0.7591
33104023	Cancer biomarkers : section A of Disease markers	2021	Circular RNA circ_0000039 enhances gastric cancer progression through miR-1292-5p/DEK axis.	hsa_circ_0000039	circ_0000039			gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_0000039 is up-regulated in gastric cancer tissues and cell lines and is associated with poor tumor differentiation. Functionally, it promotes GC cell proliferation, motility, migration and invasion by sponging miR-1292-5p and increasing DEK expression through the circ_0000039/miR-1292-5p/DEK axis."	0.6521
33105143	"Medical principles and practice : international journal of the Kuwait University, Health Science Centre"	2020	CircHIPK3 Promotes Thyroid Cancer Tumorigenesis and Invasion through the Mirna-338-3p/RAB23 Axis.		CircHIPK3	hsa_circ_HIPK3	HIPK3	thyroid cancer 	MONDO:0002108	thyroid cancer	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in thyroid cancer tissues and cell lines. Functional knockdown experiments indicate that circHIPK3 promotes TC cell growth, migration and invasion. Mechanistically, the study proposes that circHIPK3 promotes tumorigenesis and invasiveness through the miR-338-3p/RAB23 regulatory axis."	0.6777
33107911	Toxicological sciences : an official journal of the Society of Toxicology	2021	Tobacco-Related Exposure Upregulates Circ_0035266 to Exacerbate Inflammatory Responses in Human Bronchial Epithelial Cells.	hsa_circ_0035266	circ_0035266	hsa_circ_AP4E1	AP4E1	NNK+LPS-induced inflammatory responses 	MONDO:0005550	infectious disease	up-regulated	RT-qPCR; Microarray	"circ_0035266 is upregulated in BEAS-2B human bronchial epithelial cells after combined NNK and LPS exposure. It promotes inflammatory responses by sponging miR-181d-5p, increasing DDX3X expression, and enhancing IL-6 and IL-8 secretion."	0.7656
33108919	Current eye research	2021	CircTET1 Inhibits Retinoblastoma Progression via Targeting miR-492 and miR-494-3p through Wnt/beta-catenin Signaling Pathway.	hsa_circ_0093996	CircTET1	hsa_circ_TET1	TET1	retinoblastoma 	MONDO:0008380	retinoblastoma	down-regulated	RT-qPCR	"CircTET1/hsa_circ_0093996 is down-regulated in retinoblastoma tissues and cells. It functions as a tumor suppressor by sponging miR-492 and miR-494-3p, thereby inhibiting Wnt/beta-catenin signaling and reducing RB cell proliferation, migration, invasion and xenograft tumor growth while promoting apoptosis and G0/G1 arrest."	0.7801
33110207	Cancer gene therapy	2021	circ_001504 promotes the development of renal cell carcinoma by sponging microRNA-149 to increase NUCB2.		circ_001504			renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR; Microarray	"circ_001504 is up-regulated in RCC tissues and cell lines and acts as an oncogenic circRNA. It promotes RCC progression by sponging miR-149 and increasing NUCB2 expression, thereby enhancing proliferation, migration, invasion and tumor growth while suppressing apoptosis."	0.8037
33113213	Experimental dermatology	2021	Characterization of circular RNA transcriptomes in psoriasis and atopic dermatitis reveals disease-specific expression profiles.		ciRS-7 			psoriasis	MONDO:0005083	psoriasis	down-regulated	ISH; RNA-seq	"ciRS-7/CDR1as was identified as a psoriasis-associated circRNA that is markedly downregulated in psoriasis lesional skin, including relative to AD lesional skin. Its expression profile showed strong diagnostic potential for distinguishing psoriasis from AD, but no experimentally validated functional mechanism was established in this study."	0.5047
33113213	Experimental dermatology	2021	Characterization of circular RNA transcriptomes in psoriasis and atopic dermatitis reveals disease-specific expression profiles.		circZRANB1	hsa_circ_ZRANB1	ZRANB1	psoriasis	MONDO:0005083	psoriasis	up-regulated	RNA-seq	"circZRANB1 was identified as an upregulated circRNA in psoriasis lesional skin and was more abundant in psoriasis lesional skin than AD lesional skin. It showed strong diagnostic biomarker potential for distinguishing psoriasis from AD, while Sanger sequencing confirmed its back-splicing junction and circularity."	0.6238
33113213	Experimental dermatology	2021	Characterization of circular RNA transcriptomes in psoriasis and atopic dermatitis reveals disease-specific expression profiles.		ciRS-7 			atopic dermatitis 	MONDO:0002406	dermatitis	down-regulated	ISH; RNA-seq	"ciRS-7/CDR1as was identified as a psoriasis-associated circRNA that is markedly downregulated in psoriasis lesional skin, including relative to AD lesional skin. Its expression profile showed strong diagnostic potential for distinguishing psoriasis from AD, but no experimentally validated functional mechanism was established in this study."	0.5047
33113213	Experimental dermatology	2021	Characterization of circular RNA transcriptomes in psoriasis and atopic dermatitis reveals disease-specific expression profiles.		circZRANB1	hsa_circ_ZRANB1	ZRANB1	atopic dermatitis 	MONDO:0002406	dermatitis	up-regulated	RNA-seq	"circZRANB1 was identified as an upregulated circRNA in psoriasis lesional skin and was more abundant in psoriasis lesional skin than AD lesional skin. It showed strong diagnostic biomarker potential for distinguishing psoriasis from AD, while Sanger sequencing confirmed its back-splicing junction and circularity."	0.6238
33118120	"Cellular oncology (Dordrecht, Netherlands)"	2021	Circular RNA circCSNK1G3 induces HOXA10 signaling and promotes the growth and metastasis of lung adenocarcinoma cells through hsa-miR-143-3p sponging.	hsa_circ_0001522	circCSNK1G3 	hsa_circ_CSNK1G3	CSNK1G3	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circCSNK1G3 (hsa_circ_0001522) is up-regulated in LUAD tissues and cell lines and functions as an oncogenic circRNA. It is predominantly cytoplasmic and promotes LUAD proliferation, migration, invasion, metastasis and xenograft tumor growth by sponging hsa-miR-143-3p and enhancing HOXA10 signaling. Its expression is associated with pathologic stage, tumor size and lymph node metastasis."	0.8399
33121682	Biochemical and biophysical research communications	2021	circPGAM1 enhances autophagy signaling during laryngocarcinoma drug resistance by regulating miR-376a.		circPGAM1	hsa_circ_PGAM1	PGAM1	laryngocarcinoma	MONDO:0002358	laryngeal carcinoma	up-regulated	RT-qPCR	"circPGAM1 is up-regulated in laryngocarcinoma tumors and promotes resistance to cisplatin. Mechanistically, it interacts with miR-376a as a ceRNA and regulates the downstream autophagy-related effector ATG2A/autophagy signaling. High circPGAM1 expression is associated with higher tumor stage and poorer survival."	0.6474
33122825	Oncogene	2021	circSETD3 regulates MAPRE1 through miR-615-5p and miR-1538 sponges to promote migration and invasion in nasopharyngeal carcinoma.		circSETD3	hsa_circ_SETD3	SETD3	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circSETD3 is significantly upregulated in NPC cell lines and clinical tissues. It promotes NPC migration, invasion, and lung metastasis by acting as a cytoplasmic ceRNA sponge for miR-615-5p and miR-1538, thereby increasing MAPRE1 expression, reducing alpha-tubulin acetylation, promoting dynamic cytoskeleton assembly, and activating EMT. The study proposes circSETD3 as a potential diagnostic and therapeutic biomarker for NPC."	0.8771
33123829	Biotechnology letters	2021	Circular RNA circ_0032821 contributes to oxaliplatin (OXA) resistance of gastric cancer cells by regulating SOX9 via miR-515-5p.	hsa_circ_0032821	circ_0032821 			gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"Exosomal circ_0032821 is up-regulated in oxaliplatin-resistant gastric cancer cells and their exosomes. It promotes oxaliplatin resistance, proliferation, migration, invasion, and tumor growth by sponging miR-515-5p to increase SOX9 expression, suggesting a potential therapeutic target for gastric cancer chemoresistance."	0.5627
33126007	"Blood cells, molecules & diseases"	2021	Circ-PTK2 promotes the proliferation and suppressed the apoptosis of acute myeloid leukemia cells through targeting miR-330-5p/FOXM1 axis.	hsa_circ_0005273	circular RNA protein tyrosine kinase 2 	hsa_circ_PTK2	PTK2	acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; Microarray	"Circ-PTK2 is up-regulated in AML bone marrow samples and AML cell lines, and high expression is associated with shorter survival. Functionally, circ-PTK2 promotes AML cell proliferation and suppresses apoptosis. Mechanistically, circ-PTK2 sponges miR-330-5p to increase FOXM1 expression, forming a circ-PTK2/miR-330-5p/FOXM1 regulatory axis."	0.7113
33128289	Molecular carcinogenesis	2020	Circ0106714 inhibits tumorigenesis of colorectal cancer by sponging miR-942-5p and releasing DLG2 via Hippo-YAP signaling.	hsa_circ_0106714	Circ0106714 	hsa_circ_TADA2A	TADA2A	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	"circ0106714 is a human TADA2A-derived circRNA that is significantly downregulated in colorectal cancer tissues and cell lines. It functions as a tumor suppressor by sponging miR-942-5p, releasing DLG2, and promoting YAP phosphorylation through Hippo-YAP signaling, thereby inhibiting proliferation, migration, invasion, metastasis and promoting apoptosis/cell-cycle arrest."	0.8256
33128584	Archives of gynecology and obstetrics	2021	Circular RNA circ_0000043 promotes endometrial carcinoma progression by regulating miR-1271-5p/CTNND1 axis.	hsa_circ_0000043	circ_0000043 	hsa_circ_PUM1	PUM1	endometrial carcinoma 	MONDO:0002447	endometrial carcinoma	up-regulated	RT-qPCR	"circ_0000043 is up-regulated in endometrial carcinoma tissues and cell lines. It promotes EC progression by sponging miR-1271-5p and thereby increasing CTNND1 expression, leading to enhanced proliferation, migration, invasion, cell cycle progression and xenograft tumor growth, while suppressing apoptosis. The circ_0000043/miR-1271-5p/CTNND1 axis is proposed as a potential therapeutic target for EC."	0.742
33128699	Human cell	2021	Circ0001320 inhibits lung cancer cell growth and invasion by regulating TNFAIP1 and TPM1 expression through sponging miR-558.	hsa_circ_0001320 				lung cancer 	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	circ0001320 is down-regulated in lung cancer cells and tissues and acts as a tumor-suppressive circRNA. It is mainly cytoplasmic and suppresses lung cancer cell proliferation and invasion while promoting apoptosis by sponging miR-558 and thereby up-regulating TNFAIP1 and TPM1. The circ0001320/miR-558/TNFAIP1 and TPM1 axis may have diagnostic and therapeutic relevance in lung cancer.	0.7507
33131409	"Cell cycle (Georgetown, Tex.)"	2020	Depletion of circ_0007841 inhibits multiple myeloma development and BTZ resistance via miR-129-5p/JAG1 axis.	hsa_circ_0007841	circ_0007841	hsa_circ_SEC61A1	SEC61A1	multiple myeloma 	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR	"Circ_0007841 is up-regulated in MM bone marrow aspirates and cell lines, and high expression is associated with poorer survival. Functionally, circ_0007841 acts as an oncogenic circRNA that promotes proliferation, metastasis, tumor growth and BTZ resistance while suppressing apoptosis. Mechanistically, it sponges miR-129-5p to increase JAG1 expression, forming a circ_0007841/miR-129-5p/JAG1 regulatory axis."	0.8593
33131417	"Cell cycle (Georgetown, Tex.)"	2020	Circ_0008450 downregulates Runx3 to promote the proliferation and epithelial-mesenchymal transition of human keratinized epithelial cells.	hsa_circ_0008450	circ_0008450			keloid	MONDO:0005348	keloid	up-regulated	RT-qPCR	"circ_0008450 is up-regulated in keloid tissues and promotes keratinized epithelial cell proliferation, migration, and EMT while inhibiting apoptosis. Mechanistically, it negatively regulates Runx3 and suppresses the TGF-beta/Smad pathway; its knockdown exerts anti-keloid effects."	0.4245
33135071	Journal of biochemistry	2021	CircRNA_0092516 regulates chondrocyte proliferation and apoptosis in osteoarthritis through the miR-337-3p/PTEN axis.		circRNA_0092516 	hsa_circ_NT5C2	NT5C2	osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circRNA_0092516 is up-regulated in OA cartilage tissues and IL-1beta-stimulated chondrocytes. Its knockdown alleviates OA-related phenotypes by promoting chondrocyte proliferation, inhibiting apoptosis and inflammatory mediator release, and regulating the miR-337-3p/PTEN axis with effects on NF-kappaB signaling."	0.7045
33140323	Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract	2021	Downregulating circRNA_0044516 Inhibits Cell Proliferation in Gastric Cancer Through miR-149/Wnt1/beta-catenin Pathway.		circRNA_0044516			gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circRNA_0044516 is upregulated in gastric cancer tissues and cell lines and functions as an oncogenic circRNA. It targets miR-149 to regulate the Wnt1/beta-catenin pathway, thereby promoting GC cell viability/proliferation and suppressing apoptosis; knockdown also inhibits HGC-27 xenograft tumor growth in nude mice."	0.7032
33148417	Life sciences	2021	Downregulation of circular RNA HECTD1 induces neuroprotection against ischemic stroke through the microRNA-133b/TRAF3 pathway.		circRNA HECTD1 	mmu_circ_HECTD1	HECTD1	ischemic stroke 	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR	"circ-HECTD1 is up-regulated in OGD-treated HT22 neuronal cells and MCAO mouse ischemic stroke models. It promotes ischemic neuronal injury by sponging miR-133b, relieving miR-133b-mediated repression of TRAF3, and enhancing apoptosis and NF-kappaB-related injury signaling; circ-HECTD1 knockdown is neuroprotective."	0.5627
33151455	Cell and tissue research	2021	CircRNA-23525 regulates osteogenic differentiation of adipose-derived mesenchymal stem cells via miR-30a-3p.		circRNA-23525 			bone-related diseases 	MONDO:0005381	bone disorder	up-regulated	RT-qPCR; Microarray	"circRNA-23525 is up-regulated during osteoblastic differentiation of mouse ADSCs and acts as a positive regulator of osteogenesis. Mechanistically, it sponges miR-30a-3p, relieves repression of Runx2, and increases osteogenic markers and mineralization, suggesting potential relevance for bone regeneration and tissue engineering."	0.5495
33155080	Journal of gastroenterology	2021	Circular RNA TMEM87A promotes cell proliferation and metastasis of gastric cancer by elevating ULK1 via sponging miR-142-5p.	hsa_circ_0034803	circTMEM87A 	hsa_circ_TMEM87A	TMEM87A	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"circTMEM87A is up-regulated in gastric cancer tissues and cell lines, and high expression predicts poorer 3-year overall survival. Functionally, circTMEM87A promotes GC cell proliferation, migration, invasion, EMT, autophagy, xenograft tumor growth and metastasis while inhibiting apoptosis. Mechanistically, circTMEM87A acts as a miR-142-5p sponge to elevate ULK1 expression, and its formation is at least partly promoted by QKI."	0.8778
33159503	IUBMB life	2021	Soy isoflavone genistein inhibits hsa_circ_0031250/miR-873-5p/FOXM1 axis to suppress non-small-cell lung cancer progression.	hsa_circ_0031250	circ_0031250	hsa_circ_PRMT5	PRMT5	non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0031250/circ_0031250 is up-regulated in NSCLC tissues and cell lines and is reduced by genistein treatment. It functions as an oncogenic circRNA by sponging miR-873-5p to regulate FOXM1, thereby promoting proliferation, migration, invasion and tumor growth while inhibiting apoptosis. Knockdown of circ_0031250 enhances the anti-NSCLC effects of genistein in vitro and in a cell line-derived xenograft model."	0.78
33160003	Cancer letters	2021	Circular RNA TGFBR2 acts as a ceRNA to suppress nasopharyngeal carcinoma progression by sponging miR-107.	hsa_circ_0005224	circTGFBR2	hsa_circ_TGFBR2	TGFBR2	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	down-regulated	RT-qPCR; ISH	"circTGFBR2 is a TGFBR2-derived circRNA downregulated in NPC tissues and cells. It functions as a tumor suppressor by sponging miR-107, increasing TGFBR2 expression, inhibiting PI3K/Akt activity and EMT, and suppressing proliferation, migration, invasion, tumor growth, and metastasis. Higher circTGFBR2 expression is associated with favorable NPC prognosis."	0.8648
33166591	Life sciences	2021	CircSFMBT2 facilitates vascular smooth muscle cell proliferation by targeting miR-331-3p/HDAC5.	hsa_circ_0000212	circSFMBT2 	hsa_circ_SFMBT2	SFMBT2	angioleiomyoma	MONDO:0006646	angioleiomyoma	up-regulated	RT-qPCR	"circSFMBT2 (hsa_circ_0000212) is up-regulated in human restenosis/neointimal tissue and PDGF-BB-treated human VSMCs. It promotes VSMC proliferation, migration, cell-cycle progression, and phenotypic modulation by sponging miR-331-3p and increasing HDAC5, which regulates Aggf1. The study suggests circSFMBT2 knockdown as a potential therapeutic strategy for restenosis and proliferative vascular diseases."	0.8338
33188501	Journal of molecular neuroscience : MN	2021	Circ-VPS18 Knockdown Enhances TMZ Sensitivity and Inhibits Glioma Progression by MiR-370/RUNX1 Axis.		circ-VPS18	hsa_circ_VPS18	VPS18	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR	"Circ-VPS18 is upregulated in TMZ-resistant glioma tissues and cells. Its knockdown increases TMZ sensitivity and suppresses glioma progression by inducing apoptosis and inhibiting viability, migration and invasion. Mechanistically, circ-VPS18 functions as a sponge for miR-370 to regulate RUNX1 expression."	0.6536
33201331	Digestive diseases and sciences	2021	Circular RNA Paired-Related Homeobox 1 Promotes Gastric Carcinoma Cell Progression via Regulating MicroRNA-665/YWHAZ Axis.	hsa_circ_0004370	Circular RNA paired-related homeobox 1 	hsa_circ_PRRX1	PRRX1	gastric carcinoma 	MONDO:0004950	gastric carcinoma	up-regulated	RT-qPCR; Microarray	"In gastric carcinoma, circ-PRRX1/hsa_circ_0004370 is upregulated in tumor tissues and GC cell lines. It promotes malignant progression by enhancing proliferation, migration, invasion, and in vivo tumor growth while inhibiting apoptosis. Mechanistically, circ-PRRX1 acts as a miR-665 sponge to regulate YWHAZ expression through a circ-PRRX1/miR-665/YWHAZ axis."	0.6829
33203523	Life sciences	2021	Circ_PSD3 promotes the progression of papillary thyroid carcinoma via the miR-637/HEMGN axis.	hsa_circ_0004458	circRNA pleckstrin and Sec7 domain containing 3 	hsa_circ_PSD3	PSD3	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"Circ_PSD3 is up-regulated in PTC tissues and cell lines and acts as an oncogenic circRNA. It promotes PTC cell cycle progression, proliferation, migration, invasion and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ_PSD3 sponges miR-637 to up-regulate HEMGN and activate PI3K/Akt signaling, suggesting the circ_PSD3/miR-637/HEMGN axis as a potential therapeutic target."	0.7595
33203701	Cancer research	2021	circIGHG-Induced Epithelial-to-Mesenchymal Transition Promotes Oral Squamous Cell Carcinoma Progression via miR-142-5p/IGF2BP3 Signaling.	hsa_circ_0000579	circIGHG	hsa_circ_IGHG		oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR; Northern Blot; Microarray	"circIGHG (hsa_circ_0000579) is upregulated in OSCC tissues and cell lines and high expression predicts recurrence and poor overall survival. Mechanistically, circIGHG mainly localizes in the cytoplasm, sponges miR-142-5p, increases IGF2BP3 activity, and induces IGF2BP3-mediated EMT, thereby promoting OSCC proliferation, invasion, metastasis, and anti-apoptotic behavior."	0.8942
33207953	Circulation	2021	Circular RNA CircMAP3K5 Acts as a MicroRNA-22-3p Sponge to Promote Resolution of Intimal Hyperplasia Via TET2-Mediated Smooth Muscle Cell Differentiation.	hsa_circ_0009034	CircMAP3K5 	hsa_circ_MAP3K5		intimal hyperplasia 	MONDO:0005043	hyperplasia	down-regulated	RT-qPCR; RNA-seq	"CircMAP3K5 is down-regulated in CHD arteries and in wire-injury-associated intimal hyperplasia. It functions as a cytoplasmic miR-22-3p sponge, increasing TET2 expression to promote VSMC differentiation and suppress SMC proliferation, thereby reducing neointima formation. The CircMAP3K5/miR-22-3p/TET2 axis is proposed as a therapeutic target for intimal hyperplasia-related vascular disease."	0.8573
33207953	Circulation	2021	Circular RNA CircMAP3K5 Acts as a MicroRNA-22-3p Sponge to Promote Resolution of Intimal Hyperplasia Via TET2-Mediated Smooth Muscle Cell Differentiation.	mmu_circ_0002104	CircMAP3K5 	mmu_circ_Map3k5		intimal hyperplasia 	MONDO:0005043	hyperplasia	down-regulated	RT-qPCR; RNA-seq	"CircMAP3K5 is down-regulated in CHD arteries and in wire-injury-associated intimal hyperplasia. It functions as a cytoplasmic miR-22-3p sponge, increasing TET2 expression to promote VSMC differentiation and suppress SMC proliferation, thereby reducing neointima formation. The CircMAP3K5/miR-22-3p/TET2 axis is proposed as a therapeutic target for intimal hyperplasia-related vascular disease."	0.8573
33209488	Journal of gastrointestinal oncology	2020	CircTBL1XR1/miR-424 axis regulates Smad7 to promote the proliferation and metastasis of colorectal cancer.		circTBL1XR1 	hsa_circ_TBL1XR1	TBL1XR1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circTBL1XR1 is up-regulated in colorectal cancer tissues and cell lines and is associated with metastatic disease. It promotes colorectal cancer cell proliferation, migration, invasion, EMT and tumor growth by sponging miR-424 and relieving miR-424-mediated repression of Smad7. The study proposes the circTBL1XR1/miR-424/Smad7/MAPK8 pathway as a potential therapeutic target in colon cancer."	0.7126
33220169	IUBMB life	2021	Circ_0109046 promotes the malignancy of endometrial carcinoma cells through the microRNA-105/SOX9/Wnt/beta-catenin axis.		Circ_0109046 	hsa_circ_ZNF700	ZNF700	endometrial carcinoma 	MONDO:0002447	endometrial carcinoma	up-regulated	RT-qPCR	"Circ_0109046 is up-regulated in endometrial carcinoma tissues and cell lines, and high expression is associated with advanced stage, lymph node metastasis, and poor survival. Functionally, Circ_0109046 promotes EC cell proliferation, migration, invasion, angiogenesis, and xenograft tumor growth while suppressing apoptosis. Mechanistically, it acts as a cytoplasmic ceRNA for miR-105 to increase SOX9 expression and activate Wnt/beta-catenin signaling."	0.8428
33232618	Cancer biotherapy & radiopharmaceuticals	2022	Circ_0016760 Acts as a Sponge of MicroRNA-4295 to Enhance E2F Transcription Factor 3 Expression and Facilitates Cell Proliferation and Glycolysis in Non-Small Cell Lung Cancer.	hsa_circ_0016760	circ_0016760			nonsmall cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"Circ_0016760 is upregulated in NSCLC tissues and cell lines. It promotes NSCLC cell proliferation, PCNA expression, glycolysis/glucose consumption, and xenograft tumor growth by sponging miR-4295 to increase E2F3 expression. The study proposes circ_0016760 as a potential target for NSCLC diagnosis and treatment."	0.6479
33232736	Cellular signalling	2021	CircTP53 promotes colorectal cancer by acting as a miR-876-3p sponge to increase cyclin-dependent kinase-like 3 expression.	hsa_circ_0107702	CircTP53 	hsa_circ_TP53	TP53	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circTP53 is up-regulated in colorectal cancer tissues and colorectal carcinoma cell lines. It promotes proliferation, migration, invasion and xenograft tumor growth while suppressing apoptosis, functioning through a ceRNA mechanism in which circTP53 sponges miR-876-3p to elevate CDKL3 expression."	0.7552
33237453	Molecular and cellular biochemistry	2021	The circular RNAs differential expression profiles in the metastasis of salivary adenoid cystic carcinoma cells.		hsa_circRNA_092556			salivary adenoid cystic carcinoma 	MONDO:0003175	salivary gland adenoid cystic carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_092556 was identified by microarray and validated by qRT-PCR as up-regulated in highly metastatic SACC-LM cells compared with SACC-83 cells. The study placed it in a predicted circRNA-miRNA-mRNA network, suggesting a potential ceRNA-related role in SACC metastasis, but no direct functional assays were performed for this circRNA."	0.2465
33237453	Molecular and cellular biochemistry	2021	The circular RNAs differential expression profiles in the metastasis of salivary adenoid cystic carcinoma cells.		hsa_circRNA_101379			salivary adenoid cystic carcinoma 	MONDO:0003175	salivary gland adenoid cystic carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_101379 was identified by microarray and validated by qRT-PCR as up-regulated in highly metastatic SACC-LM cells compared with SACC-83 cells. It was included as a core circRNA in the predicted circRNA-miRNA-mRNA network, suggesting a possible ceRNA-related contribution to SACC metastasis, but the study did not perform direct functional assays for this circRNA."	0.2465
33237453	Molecular and cellular biochemistry	2021	The circular RNAs differential expression profiles in the metastasis of salivary adenoid cystic carcinoma cells.		hsa_circRNA_001982 			salivary adenoid cystic carcinoma 	MONDO:0003175	salivary gland adenoid cystic carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_001982 was up-regulated in highly metastatic SACC-LM cells and functionally promoted SACC cell migration and invasion. Mechanistically, it directly interacted with miR-181a-5p and promoted metastasis-related phenotypes via miR-181a-5p down-regulation, suggesting potential biomarker relevance for distant SACC metastasis."	0.5804
33242258	Epigenomics	2020	Novel insights toward human stroke-related epigenetics: circular RNA and its impact in poststroke processes.		circ_PLEKHH1 	hsa_circ_PLEKHH1	PLEKHH1	ischemic stroke 	MONDO:1060198	ischemic stroke	down-regulated	RNA-seq	"circ_PLEKHH1 is a novel PLEKHH1-derived circRNA down-regulated in human ischemic stroke lesion tissue. The study suggests it may help discriminate stroke from control brain tissue, but it was not subjected to downstream target or pathway analysis."	0.348
33242258	Epigenomics	2020	Novel insights toward human stroke-related epigenetics: circular RNA and its impact in poststroke processes.	hsa_circ_0005562				ischemic stroke 	MONDO:1060198	ischemic stroke	down-regulated	RNA-seq	hsa_circ_0005562 was identified by RNA-seq as down-regulated in human ischemic stroke lesion tissue. The study proposes it as a candidate stroke biomarker and predicts RBP/miRNA-mediated gene regulatory roles.	0.348
33242258	Epigenomics	2020	Novel insights toward human stroke-related epigenetics: circular RNA and its impact in poststroke processes.	hsa_circ_0077426				ischemic stroke 	MONDO:1060198	ischemic stroke	down-regulated	RNA-seq	"hsa_circ_0077426 was identified by RNA-seq as down-regulated in human ischemic stroke lesion tissue. It is proposed as a candidate biomarker and, based on computational prediction, may act through RBP interactions and miRNA-related gene regulation."	0.348
33242258	Epigenomics	2020	Novel insights toward human stroke-related epigenetics: circular RNA and its impact in poststroke processes.	hsa_circ_0103896				ischemic stroke 	MONDO:1060198	ischemic stroke	down-regulated	RNA-seq	hsa_circ_0103896 was identified as down-regulated in human ischemic stroke lesion tissue by RNA-seq. The study suggests biomarker potential and predicts that it may be involved in RBP- and miRNA-mediated regulatory processes related to poststroke biology.	0.348
33242258	Epigenomics	2020	Novel insights toward human stroke-related epigenetics: circular RNA and its impact in poststroke processes.	hsa_circ_0078299				ischemic stroke 	MONDO:1060198	ischemic stroke	down-regulated	RNA-seq	"hsa_circ_0078299 is down-regulated in human ischemic stroke lesion tissue and was highlighted as a major element in the stroke molecular network. Its predicted interactions include RBPs such as FMRP and a miRNA-target gene network in which FXN is prominent, suggesting biomarker and mechanistic relevance."	0.348
33247421	Digestive diseases and sciences	2021	HIPK3 Circular RNA Promotes Metastases of HCC Through Sponging miR-338-3p to Induce ZEB2 Expression.		circHIPK3 	hsa_circ_HIPK3	HIPK3	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH	"circHIPK3 is upregulated in HCC tissues and cell lines, and higher expression is associated with poorer overall survival. Functionally, circHIPK3 promotes HCC migration, invasion, EMT and lung metastasis. Mechanistically, it sponges miR-338-3p to increase ZEB2 expression and regulate EMT-associated proteins."	0.7791
33247530	Head & neck	2021	Circular RNA circ_0004507 contributes to laryngeal cancer progression and cisplatin resistance by sponging miR-873 to upregulate multidrug resistance 1 and multidrug resistance protein 1.	hsa_circ_0004507		hsa_circ_SAE1	SAE1	laryngeal cancer	MONDO:0002358	laryngeal carcinoma	up-regulated	RT-qPCR	"circ_0004507 is up-regulated in laryngeal cancer tissues and is associated with advanced clinicopathological features and cisplatin resistance. Functionally, circ_0004507 promotes proliferation, migration, invasion, tumor growth and chemoresistance while suppressing apoptosis, partly by sponging miR-873 and maintaining MDR1/MRP1 expression. Its knockdown increases cisplatin sensitivity in vitro and in a cell line-derived xenograft model."	0.8122
33249762	IUBMB life	2021	Oxidized low-density lipoprotein accelerates the injury of endothelial cells via circ-USP36/miR-98-5p/VCAM1 axis.	hsa_circ_0003204	circ-USP36 	hsa_circ_USP36	USP36	atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"In an ox-LDL-induced HUVEC model of atherosclerosis-related endothelial injury, circ-USP36 is up-regulated and aggravates endothelial cell injury by inhibiting viability and promoting apoptosis and inflammation. Mechanistically, circ-USP36 sponges miR-98-5p to increase VCAM1 expression, forming a circ-USP36/miR-98-5p/VCAM1 regulatory axis that may represent a therapeutic target for endothelial dysfunction in AS."	0.6253
33253995	Placenta	2021	Circ_0001438 participates in the pathogenesis of preeclampsia via the circ_0001438/miR-942/NLRP3 regulatory network.	hsa_circ_0001438	circ_0001438	hsa_circ_LARP1B	LARP1B	preeclampsia 	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR	"circ_0001438 is up-regulated in placental tissues from patients with preeclampsia. In HTR-8/Svneo trophoblast cells, circ_0001438 suppresses proliferation, migration and invasion while promoting apoptosis and inflammatory responses. Mechanistically, it acts through the circ_0001438/miR-942/NLRP3 regulatory network and may serve as a therapeutic biomarker for PE."	0.6536
33259864	Life sciences	2021	"Circ-UBR1 facilitates proliferation, metastasis, and inhibits apoptosis in breast cancer by regulating the miR-1299/CCND1 axis."	hsa_circ_0103552	circ-UBR1 	hsa_circ_UBR1	UBR1	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"This study found that circ-UBR1 is up-regulated in breast cancer tissues and cell lines. Functionally, circ-UBR1 promotes proliferation, migration, invasion, cell-cycle progression and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ-UBR1 acts as a ceRNA for miR-1299 to increase CCND1 expression, forming a circ-UBR1/miR-1299/CCND1 regulatory axis."	0.8005
33271241	Journal of ethnopharmacology	2021	Transcriptional profiling and circRNA-miRNA-mRNA network analysis identify the biomarkers in Sheng-ji Hua-yu formula treated diabetic wound healing.		circRNA-Crebrf	mmu_circ_Crebrf	Crebrf	diabetic wounds 	MONDO:0000960	diabetic peripheral angiopathy	dysregulated	RT-qPCR; RNA-seq	"circRNA-Crebrf was identified as one of four core circRNAs whose expression differed between SJHY formula-treated and untreated diabetic wounds during the inflammation phase. The study proposes it as a potential biomarker for evaluating SJHY formula efficacy in diabetic wound healing, but does not report a specific validated miRNA-mRNA axis for this circRNA."	0.3684
33271241	Journal of ethnopharmacology	2021	Transcriptional profiling and circRNA-miRNA-mRNA network analysis identify the biomarkers in Sheng-ji Hua-yu formula treated diabetic wound healing.		circRNA-Ddx19a	mmu_circ_Ddx19a	Ddx19a	diabetic wounds 	MONDO:0000960	diabetic peripheral angiopathy	dysregulated	RT-qPCR; RNA-seq	"circRNA-Ddx19a was identified as one of four core circRNAs whose expression differed between SJHY formula-treated and untreated diabetic wounds during the inflammation phase. The study proposes it as a potential biomarker for evaluating SJHY formula efficacy in diabetic wound healing, but does not report a specific validated miRNA-mRNA axis for this circRNA."	0.3684
33271241	Journal of ethnopharmacology	2021	Transcriptional profiling and circRNA-miRNA-mRNA network analysis identify the biomarkers in Sheng-ji Hua-yu formula treated diabetic wound healing.		circRNA-Krt13 	mmu_circ_Krt13	Krt13	diabetic wounds 	MONDO:0000960	diabetic peripheral angiopathy	dysregulated	RT-qPCR; RNA-seq	"circRNA-Krt13 was identified as a core circRNA dysregulated between SJHY formula-treated and untreated diabetic wounds, with significant differences in both inflammation and maturation phases. The study supports a circRNA_Krt13/miR-665-3p/Itga3 ceRNA-like pathway that may be important in the inflammation phase of diabetic wound healing and may serve as a biomarker of SJHY formula treatment response."	0.3684
33271241	Journal of ethnopharmacology	2021	Transcriptional profiling and circRNA-miRNA-mRNA network analysis identify the biomarkers in Sheng-ji Hua-yu formula treated diabetic wound healing.		circRNA-Krt14 	mmu_circ_Krt14	Krt14	diabetic wounds 	MONDO:0000960	diabetic peripheral angiopathy	dysregulated	RT-qPCR; RNA-seq	"circRNA-Krt14 was identified as a core circRNA dysregulated between SJHY formula-treated and untreated diabetic wounds, with significant differences in both inflammation and maturation phases. The study supports a circRNA_Krt14/miR-706/Mylk4 ceRNA-like pathway that is highly correlated with diabetes-associated wound healing defects in the maturation phase and may serve as a biomarker of SJHY formula treatment response."	0.3684
33277756	The journal of gene medicine	2021	Circ-PRMT5 promotes breast cancer by the miR-509-3p/TCF7L2 axis activating the PI3K/AKT pathway.		Circ-PRMT5	hsa_circ_PRMT5	PRMT5	breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"Circ-PRMT5 is upregulated in breast cancer tissues and cell lines, and high expression is associated with poor overall survival. It promotes malignant phenotypes by sponging miR-509-3p, increasing TCF7L2 expression, and activating the PI3K/AKT/mTOR pathway, thereby enhancing proliferation and angiogenesis while suppressing apoptosis."	0.7941
33283616	"Cell cycle (Georgetown, Tex.)"	2020	The circ_0004463/miR-380-3p/FOXO1 axis modulates mitochondrial respiration and bladder cancer cell apoptosis.	hsa_circ_0004463	circ_0004463			bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; Microarray	"circ_0004463 is downregulated in bladder carcinoma tissues and bladder cancer cell lines. It acts as a tumor suppressor by inhibiting cell viability/proliferation and mitochondrial respiration while promoting apoptosis. Mechanistically, circ_0004463 binds miR-380-3p and relieves miR-380-3p-mediated repression of FOXO1, forming the circ_0004463/miR-380-3p/FOXO1 axis."	0.7759
33283885	Hematological oncology	2021	Hsa_circ_0002483 regulates miR-758-3p/MYC axis to promote acute myeloid leukemia progression.	hsa_circ_0002483	circ_0002483	hsa_circ_PTK2	PTK2	acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"Hsa_circ_0002483/circ_0002483 is up-regulated in AML bone marrow samples and AML cell lines. Functionally, circ_0002483 promotes AML cell proliferation and cell cycle progression while inhibiting apoptosis. Mechanistically, it regulates the miR-758-3p/MYC axis, suggesting a potential therapeutic target in AML."	0.8111
33285422	"Pathology, research and practice"	2021	Circ_0025033 promotes the progression of ovarian cancer by activating the expression of LSM4 via targeting miR-184.	hsa_circ_0025033	circ_0025033	hsa_circ_FOXM1	FOXM1	ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"Circ_0025033 is up-regulated in ovarian cancer tissues and cell lines. It promotes colony formation, migration, invasion, glycolysis metabolism and xenograft tumor growth by acting as a ceRNA for miR-184 to increase LSM4 expression, suggesting potential diagnostic or therapeutic relevance."	0.7126
33289016	Carcinogenesis	2021	The promoting effects of hsa_circ_0050102 in pancreatic cancer and the molecular mechanism by targeting miR-1182/NPSR1.	hsa_circ_0050102	circ-0050102	hsa_circ_PGPEP1	PGPEP1	pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; Microarray	"hsa_circ_0050102/circ-0050102 is up-regulated in pancreatic cancer tissues and PDAC cell lines. It promotes pancreatic cancer proliferation, migration, invasion and xenograft tumor growth while suppressing apoptosis and cell-cycle arrest. Mechanistically, it functions as a ceRNA by sponging miR-1182 to increase NPSR1 expression, suggesting the circ-0050102/miR-1182/NPSR1 axis as a potential therapeutic strategy."	0.8071
33300444	Perfusion	2022	"Hsa_circ_0001445 inhibits ox-LDL-induced HUVECs inflammation, oxidative stress and apoptosis by regulating miRNA-640."	hsa_circ_0001445	circ_0001445			atherosclerosis 	MONDO:0005311	atherosclerosis	down-regulated	RT-qPCR	"Hsa_circ_0001445 is down-regulated in ox-LDL-induced HUVECs, an in vitro atherosclerosis-related endothelial injury model. Its overexpression promotes HUVEC proliferation and reduces inflammation, oxidative stress and apoptosis, at least partly by targeting miRNA-640."	0.5607
33307836	"Clinical and experimental hypertension (New York, N.Y. : 1993)"	2021	Hsa_circ_0037897 may be a risk factor for essential hypertension via hsa-miR-145-5p.	hsa_circ_0037897				essential hypertension 	MONDO:0001134	essential hypertension	up-regulated	RT-qPCR; Microarray	This case-control study found that hsa_circ_0037897 is significantly up-regulated in peripheral blood from patients with essential hypertension. The authors propose that hsa_circ_0037897 may act as a sponge for hsa-miR-145-5p in a circRNA-miRNA-mRNA network and may serve as a risk factor and diagnostic biomarker for EH.	0.5047
33316641	Thrombosis research	2021	Possible immune regulation mechanisms for the progression of chronic thromboembolic pulmonary hypertension.	hsa_circ_0002062				chronic thromboembolic pulmonary hypertension 	MONDO:0013024	chronic thromboembolic pulmonary hypertension	down-regulated	Microarray	hsa_circ_0002062 was identified as a downregulated CTEPH-associated circRNA in a bioinformatics ceRNA network. The study proposes that circ_0002062 may participate in CTEPH progression through a miR-92b-3p/miR-92a-3p-MAN2A1 axis related to Treg-mediated immune regulation.	0.1768
33316641	Thrombosis research	2021	Possible immune regulation mechanisms for the progression of chronic thromboembolic pulmonary hypertension.	hsa_circ_0022342				chronic thromboembolic pulmonary hypertension 	MONDO:0013024	chronic thromboembolic pulmonary hypertension	down-regulated	Microarray	hsa_circ_0022342 was identified as a downregulated CTEPH-associated circRNA in a bioinformatics ceRNA network. The study proposes that circ_0022342 may participate in CTEPH progression through a miR-503-5p-SLC2A3 axis related to eosinophil-associated immune regulation.	0.1768
33325136	Cell biology international	2021	Cisplatin-resistant osteosarcoma cell-derived exosomes confer cisplatin resistance to recipient cells in an exosomal circ_103801-dependent manner.		hsa_circ_103801 			osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"hsa_circ_103801 is upregulated in serum exosomes from osteosarcoma patients and in cisplatin-resistant osteosarcoma cells/exosomes. CDDP-resistant cell-derived exosomes transfer hsa_circ_103801 to recipient MG63 and U2OS cells, promoting cisplatin resistance, inhibiting apoptosis, and increasing MRP1 and P-gp expression. High serum exosomal hsa_circ_103801 expression is associated with shorter survival, suggesting prognostic value and potential as a target for overcoming OS chemoresistance."	0.6148
33325145	Cell biology international	2021	Differential expression of circular RNAs in bone marrow-derived exosomes from essential thrombocythemia patients.	hsa_circ_0014614	circDAP3 	hsa_circ_DAP3	DAP3	essential thrombocythemia 	MONDO:0005029	essential thrombocythemia	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0014614/circDAP3 is significantly down-regulated in bone marrow-derived exosomes from ET patients. The study predicts a circDAP3-centered miRNA/mRNA network involving miR-29b-1-5p and proliferation/apoptosis-related pathways, and functional assays suggest circ_0014614 inhibits K562 proliferation and megakaryocytic differentiation."	0.6949
33325145	Cell biology international	2021	Differential expression of circular RNAs in bone marrow-derived exosomes from essential thrombocythemia patients.	hsa_circ_0001136	circASXL1	hsa_circ_ASXL1	ASXL1	essential thrombocythemia 	MONDO:0005029	essential thrombocythemia	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001136/circASXL1 is down-regulated in bone marrow-derived exosomes from ET patients and was validated by Sanger sequencing, divergent-primer RT-PCR, and qRT-PCR. Bioinformatics analysis predicts that circASXL1 may regulate ET-related proliferation and apoptosis programs through miR-34b-5p and other miRNAs targeting c-Met, WNT, PI3K, and TGF-beta pathways."	0.5841
33325145	Cell biology international	2021	Differential expression of circular RNAs in bone marrow-derived exosomes from essential thrombocythemia patients.	hsa_circ_0002360	circRUNX1	hsa_circ_RUNX1	RUNX1	essential thrombocythemia 	MONDO:0005029	essential thrombocythemia	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0002360/circRUNX1 is down-regulated in bone marrow-derived exosomes from ET patients and was experimentally validated at the expression and circular-structure levels. The predicted circRUNX1 miRNA/mRNA network includes miR-29b-1-5p and miR-34b-5p, suggesting possible involvement in proliferation, apoptosis, PI3K/Akt, JAK/STAT, TGF-beta, WNT and c-Met-related signaling during ET pathogenesis."	0.5841
33325513	Neuro-oncology	2021	Rolling-translated EGFR variants sustain EGFR signaling and promote glioblastoma tumorigenicity.	hsa_circ_0080229	circ-EGFR 	hsa_circ_EGFR	EGFR	glioblastoma 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; Northern Blot; RNA-seq	"circ-EGFR is up-regulated in GBM/BTICs and is derived from exons 14 and 15 of EGFR. It encodes the rolling-translated protein rtEGFR, which binds EGFR, preserves EGFR membrane localization, reduces EGFR endocytosis/ubiquitination/degradation, and sustains EGFR downstream signaling. High circ-EGFR predicts poor overall survival in GBM patients, while circ-EGFR knockdown reduces tumorigenicity and sensitizes tumors to nimotuzumab."	0.83
33325776	Animal biotechnology	2022	"Identification, biogenesis and function prediction of novel circRNA during the chicken ALV-J infection."		circRNA_3079	gga_circ_PIAS1	PIAS1	ALV-J infection 	MONDO:0025381	avian leukosis	up-regulated	RNA-seq	"circRNA_3079 is a chicken PIAS1-derived exonic circRNA that was identified as markedly up-regulated after ALV-J infection based on RNA-seq. The study validated its circular structure, stability, and cytoplasmic localization, and predicted that it may act through a circRNA-miRNA-mRNA ceRNA network involving gga-miR-1773-5p, gga-miR-6610-3p, and gga-miR-1766. Its predicted target genes are enriched in immunity- or tumor-related pathways, suggesting a possible indirect regulatory role in ALV-J infection."	0.6695
33326930	The Journal of surgical research	2021	CircDUSP16 Contributes to Cell Development in Esophageal Squamous Cell Carcinoma by Regulating miR-497-5p/TKTL1 Axis.		circDUSP16	hsa_circ_DUSP16	DUSP16	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"circDUSP16 is up-regulated in ESCC tissues, ESCC cells, and hypoxia-stimulated ESCC cells. Functionally, circDUSP16 promotes ESCC cell viability, colony formation, migration, invasion, glycolysis, and in vivo tumorigenesis. Mechanistically, it acts through a circDUSP16/miR-497-5p/TKTL1 regulatory axis by sponging miR-497-5p to positively regulate TKTL1 expression."	0.7782
33326955	International archives of allergy and immunology	2021	Diagnostic and Therapeutic Value of Hsa_circ_0002594 for T Helper 2-Mediated Allergic Asthma.	hsa_circ_0002594				asthma 	MONDO:0004979	asthma	up-regulated	RT-qPCR; Microarray	"This study found that hsa_circ_0002594 is upregulated in CD4 + T cells from patients with allergic asthma and is associated with Th2-high clinical features, FeNO, SPT positivity, and airway hyperresponsiveness. The circRNA may act through a predicted miRNA sponge/ceRNA mechanism and has potential diagnostic and treatment-response biomarker value because its expression decreases after inhaled corticosteroid therapy."	0.6895
33333383	The Journal of surgical research	2021	"Knockdown of circ_0006528 Suppresses Cell Proliferation, Migration, Invasion, and Adriamycin Chemoresistance via Regulating the miR-1236-3p/CHD4 Axis in Breast Cancer."	hsa_circ_0006528	circ_0006528			breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0006528 is up-regulated in ADM-resistant breast cancer tissues and cells and is associated with shorter overall survival. Functionally, circ_0006528 promotes proliferation, migration, invasion, ADM resistance, and tumor growth through the miR-1236-3p/CHD4 axis; its knockdown suppresses these phenotypes."	0.686
33350543	International journal of experimental pathology	2021	Circular RNA ITCH mediates H2O2-induced myocardial cell apoptosis by targeting miR-17-5p via wnt/beta-catenin signalling pathway.		circ-ITCH 	rno_circ_ITCH	ITCH	cardiovascular disease 	MONDO:0004995	cardiovascular disorder	down-regulated	RT-qPCR	"circ-ITCH is down-regulated in H2O2-induced H9c2 myocardial injury. Its overexpression protects myocardial cells by improving viability and ATP levels and suppressing apoptosis, partly through targeting miR-17-5p and negatively regulating Wnt/beta-catenin signalling."	0.5554
33351694	Cancer biotherapy & radiopharmaceuticals	2023	circ_0002060 Enhances Doxorubicin Resistance in Osteosarcoma by Regulating the miR-198/ABCB1 Axis.	hsa_circ_0002060	circ_0002060	hsa_circ_DYNC1H1	DYNC1H1	Osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ_0002060 is upregulated in osteosarcoma tissues and DOX-resistant osteosarcoma cells, and high expression is associated with poor prognosis and poor treatment response. Mechanistically, circ_0002060 sponges miR-198 to increase ABCB1 expression, thereby promoting doxorubicin resistance, proliferation, and OS progression while inhibiting apoptosis."	0.8436
33359304	Molecular and cellular endocrinology	2021	CircNFIX promotes progression of pituitary adenoma via CCNB1 by sponging miR-34a -5p.	hsa_circ_0005660	circNFIX 	hsa_circ_NFIX	NFIX	pituitary adenoma 	MONDO:0006373	pituitary gland adenoma	up-regulated	RT-qPCR	"circNFIX (hsa_circ_0005660) is up-regulated in invasive pituitary adenomas and promotes invasion, migration, proliferation, and tumor formation. Mechanistically, it sponges miR-34a-5p to up-regulate CCNB1, forming a circNFIX/miR-34a-5p/CCNB1 axis. High circNFIX expression is associated with high Knosp grade and poor prognosis, suggesting potential biomarker and therapeutic relevance."	0.7126
33359669	Life sciences	2021	Circ-CCS is identified as a cancer-promoting circRNA in lung cancer partly by regulating the miR-383/E2F7 axis.	hsa_circ_0092306	Circ-CCS 	hsa_circ_CCS	CCS	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"Circ-CCS is upregulated in lung cancer tissues and cell lines and its high expression is associated with poorer 5-year overall survival. Functionally, circ-CCS promotes lung cancer cell growth, migration, invasion, metastasis-related protein expression and xenograft tumor growth while suppressing apoptosis. Mechanistically, it acts as a miR-383 sponge to relieve repression of E2F7, forming a circ-CCS/miR-383/E2F7 oncogenic axis."	0.8281
33360372	International immunopharmacology	2021	"Circ_DHRS3 positively regulates GREM1 expression by competitively targeting miR-183-5p to modulate IL-1beta-administered chondrocyte proliferation, apoptosis and ECM degradation."	hsa_circ_0010024	circ_DHRS3 	hsa_circ_DHRS3	DHRS3	Osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circ_DHRS3 is up-regulated in osteoarthritis cartilage tissues and IL-1beta-treated human chondrocytes. Functionally, circ_DHRS3 promotes OA-like chondrocyte injury by suppressing proliferation and enhancing apoptosis and ECM degradation through a circ_DHRS3/miR-183-5p/GREM1 ceRNA axis."	0.7551
33372396	IUBMB life	2021	N6 -methyladenosine modification of circular RNA circ-ARL3 facilitates Hepatitis B virus-associated hepatocellular carcinoma via sponging miR-1305.	hsa_circ_0092493	circ-ARL3	hsa_circ_ARL3	ARL3	Hepatitis B virus-associated hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circ-ARL3 is an HBV-related, up-regulated circRNA in HBV-positive HCC, and high expression is associated with malignant clinical features and poor survival. Mechanistically, HBx-induced METTL3/YTHDC1-dependent m6A regulation increases circ-ARL3 biogenesis, and cytoplasmic circ-ARL3 promotes HCC proliferation, invasion and xenograft growth by sponging miR-1305 and derepressing oncogenic target genes."	0.8609
33382158	Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology	2021	circBICD2 targets miR-149-5p/IGF2BP1 axis to regulate oral squamous cell carcinoma progression.	hsa_circ_0001874	circBICD2 	hsa_circ_BICD2	BICD2	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circBICD2 is up-regulated in OSCC tissues and cell lines. Functionally, circBICD2 promotes OSCC proliferation, migration, invasion, glutaminolysis and xenograft tumor growth while suppressing apoptosis. Mechanistically, circBICD2 sponges miR-149-5p to regulate IGF2BP1, forming a circBICD2/miR-149-5p/IGF2BP1 axis that may serve as a potential therapeutic target for OSCC."	0.795
33382168	American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons	2021	Circular RNA Foxo3 in cardiac ischemia-reperfusion injury in heart transplantation: A new regulator and target.		circFoxo3	mmu_circ_Foxo3	Foxo3	cardiac ischemia-reperfusion injury in heart transplantation 	MONDO:0700220	disease related to transplantation	up-regulated	RT-qPCR	"In a mouse heart transplantation ischemia-reperfusion injury model and cardiomyocyte H/R model, circFoxo3 is up-regulated and appears to aggravate graft and cardiomyocyte injury. Silencing circFoxo3 reduces apoptosis/death, mitochondrial damage, fibrosis and graft dysfunction. Mechanistically, circFoxo3 interacts with Foxo3 protein and suppresses Foxo3 phosphorylation, with indirect effects on miR-433 and miR-136 expression."	0.7217
33386469	Journal of cancer research and clinical oncology	2021	CircRNA-100284 activates aurora kinase B by inducing methylation of HSP70 via microRNA-217 to promote proliferation of bladder cancer cells.		circRNA-100284 			bladder cancer	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circRNA-100284 is up-regulated in bladder cancer tissues, bladder cancer cell lines, and arsenite-transformed bladder cells. The study suggests that circRNA-100284 promotes bladder cancer cell proliferation and G1/S cell cycle transition through miR-217-associated regulation of EZH2/cyclin-D1 and activation of Aurora-B via K561-dimethylated HSP70."	0.6542
33386495	Biotechnology letters	2021	Circ_0001247 functions as a miR-1270 sponge to accelerate cervical cancer progression by up-regulating ZEB2 expression level.	hsa_circ_0001247	circ_0001247	hsa_circ_ATXN10	ATXN10	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"circ_0001247/hsa_circ_0001247 is up-regulated in cervical cancer tissues and cell lines. It promotes cervical cancer cell proliferation, migration, invasion and metastasis while inhibiting apoptosis, mainly by sponging miR-1270 to increase ZEB2 expression. The study suggests circ_0001247 may have value as a diagnostic or therapeutic basis in cervical cancer."	0.6829
33386518	Digestive diseases and sciences	2021	Circ_PGPEP1 Serves as a Sponge of miR-1297 to Promote Gastric Cancer Progression via Regulating E2F3.		circ_PGPEP1 	hsa_circ_PGPEP1	PGPEP1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circ_PGPEP1 is up-regulated in gastric cancer tissues and cell lines and is associated with TNM stage and metastasis. Functionally, it promotes GC cell proliferation, cell cycle progression, migration, invasion, and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ_PGPEP1 acts as a cytoplasmic ceRNA that sponges miR-1297 to increase E2F3 expression."	0.78
33394311	Journal of bioenergetics and biomembranes	2021	Circ_0045714 alleviates TNF-alpha-induced chondrocyte injury and extracellular matrix degradation through miR-218-5p/HRAS axis.	hsa_circ_0045714	circ_0045714			osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR	"Circ_0045714 is down-regulated in OA cartilage tissues and TNF-alpha-induced chondrocytes. Its overexpression protects chondrocytes by promoting proliferation and reducing apoptosis, inflammation, and ECM degradation, at least partly through the miR-218-5p/HRAS regulatory axis."	0.6479
33398455	Diabetologia	2021	Involvement of circHIPK3 in the pathogenesis of diabetic cardiomyopathy in mice.	mmu_circ_0001052	circHIPK3	mmu_circ_Hipk3	Hipk3	diabetic cardiomyopathy 	MONDO:0004994	cardiomyopathy	up-regulated	RT-qPCR; ISH	"In this mouse DCM study, circHIPK3 is upregulated in diabetic myocardium and in fibrotic cardiac fibroblast conditions. It promotes myocardial fibrosis and cardiac fibroblast proliferation through a ceRNA mechanism involving miR-29b-3p and Col1a1/Col3a1, leading to increased collagen I/III expression; circHIPK3 knockdown attenuates fibrosis and improves cardiac function."	0.8412
33398465	Journal of molecular histology	2021	Circular RNA RBM33 contributes to cervical cancer progression via modulation of the miR-758-3p/PUM2 axis.	hsa_circ_0001772	circRBM33	hsa_circ_RBM33	RBM33	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"circRBM33 is upregulated in cervical cancer tissues and cells, and high expression is associated with larger tumor size, advanced FIGO stage, lymph node metastasis and shorter overall survival. Functionally, circRBM33 promotes cervical cancer proliferation, migration, invasion, glycolysis and xenograft tumor growth while suppressing apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-758-3p to increase PUM2 expression."	0.8508
33399102	IET systems biology	2020	Identification and analysis of circRNA-miRNA-mRNA regulatory network in hepatocellular carcinoma.	hsa_circ_0034326				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	dysregulated	Microarray	"hsa-circ-0034326 was identified by microarray-based bioinformatics analysis as a dysregulated circRNA in HCC and a hub circRNA in a circRNA-miRNA-mRNA regulatory network. The study predicted that it may act as a ceRNA by sponging miR-25-3p and miR-4270, regulating ITGA5, SLC12A5, and NRAS-related axes in HCC, but no experimental validation was performed."	0.1768
33399102	IET systems biology	2020	Identification and analysis of circRNA-miRNA-mRNA regulatory network in hepatocellular carcinoma.	hsa_circ_0011950				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	dysregulated	Microarray	"hsa-circ-0011950 was identified by microarray-based bioinformatics analysis as a dysregulated circRNA in HCC and a hub circRNA in a circRNA-miRNA-mRNA regulatory network. The study predicted that it may function as a ceRNA by sponging miR-3692-5p and miR-4270, regulating SMAD2 and NRAS-related axes in HCC, but no experimental validation was performed."	0.1768
33403756	The journal of obstetrics and gynaecology research	2021	CircRNA DNA methyltransferase 1 silence inhibits breast cancer development by regulating micoRNA-485-3p/zinc finger E-box binding homeobox 1 axis.	hsa_circ_0049185	circ-DNMT1	hsa_circ_DNMT1	DNMT1	breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"Circ-DNMT1 is up-regulated in breast cancer tissues and cell lines. Functionally, circ-DNMT1 knockdown suppresses colony formation, migration, invasion and xenograft tumor growth while promoting apoptosis. Mechanistically, circ-DNMT1 regulates breast cancer development through the miR-485-3p/ZEB1 axis."	0.7977
33404903	Biotechnology letters	2021	Circ_0114876 promoted IL-1beta-induced chondrocyte injury by targeting miR-671/TRAF2 axis.	hsa_circ_0114876		hsa_circ_PTPRA	PTPRA	Osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circ_0114876 is up-regulated in OA tissues and IL-1beta-induced CHON-001 chondrocytes. It promotes IL-1beta-induced chondrocyte injury by sponging miR-671 and increasing TRAF2 expression, thereby reducing cell viability and promoting apoptosis and inflammatory responses. The study suggests circ_0114876 may be a potential biomarker and therapeutic target in OA."	0.8111
33405341	Dermatologic therapy	2021	Identification of differentially expressed circular RNAs in keloid and normal skin tissue by high-throughput sequencing.	hsa_circ_0001320		hsa_circ_FOXP1	FOXP1	keloid	MONDO:0005348	keloid	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001320 is significantly upregulated in keloid tissue and its expression was validated by QPCR in an expanded clinical cohort. The study confirmed direct interaction between hsa_circ_0001320 and miR-574-5p by dual-luciferase reporter assay, and proposed that it may influence keloid development through a miR-574-5p/SMAD4/TGF-beta-related mechanism."	0.6902
33405341	Dermatologic therapy	2021	Identification of differentially expressed circular RNAs in keloid and normal skin tissue by high-throughput sequencing.		circCOL5A1	hsa_circ_COL5A1	COL5A1	keloid	MONDO:0005348	keloid	up-regulated	RT-qPCR; RNA-seq	"circCOL5A1 is significantly upregulated in keloid tissues and was validated by QPCR in an expanded clinical sample set. The study links circCOL5A1 to keloid-related Wnt signaling through bioinformatics analysis, but did not experimentally define its miRNA partners or downstream molecular mechanism."	0.5466
33410156	European journal of clinical investigation	2021	CircWHSC1 serves as an oncogene to promote hepatocellular carcinoma progression.		circRNA Wolf-Hirschhorn syndrome candidate gene-1 	hsa_circ_WHSC1	WHSC1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"CircWHSC1 is up-regulated in HCC tissues, cells and patient serum-derived exosomes. It promotes HCC proliferation, migration, invasion, metastasis and xenograft tumor growth by sponging miR-142-3p and increasing HOXA1 expression. High circWHSC1 expression is associated with poor overall survival, and exosomal circWHSC1 shows diagnostic potential for HCC."	0.8146
33413028	"Cell cycle (Georgetown, Tex.)"	2021	Circ-FOXM1 knockdown suppresses non-small cell lung cancer development by regulating the miR-149-5p/ATG5 axis.		circ-FOXM1	hsa_circ_FOXM1	FOXM1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"Circ-FOXM1 is upregulated in NSCLC tissues and cells and is associated with advanced TNM stage. Functionally, circ-FOXM1 promotes NSCLC cell viability, migration, autophagy and tumor growth while suppressing apoptosis. Mechanistically, circ-FOXM1 sponges miR-149-5p to increase ATG5 expression, forming a circ-FOXM1/miR-149-5p/ATG5 regulatory axis."	0.7591
33417162	Molecular and cellular biochemistry	2022	circ_0044516 functions in the progression of gastric cancer by modulating MicroRNA-149-5p/HuR axis.	hsa_circ_0044516	circ_0044516 			gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_0044516 is up-regulated in gastric cancer cell lines and promotes malignant phenotypes, including proliferation/viability, colony formation, migration, invasion and xenograft tumor growth. Mechanistically, cytoplasmic circ_0044516 functions as a sponge for miR-149-5p to increase HuR expression, forming a circ_0044516/miR-149-5p/HuR regulatory axis that supports GC progression."	0.6867
33429194	Biochemical and biophysical research communications	2021	"Circular RNA circ_0068,888 protects against lipopolysaccharide-induced HK-2 cell injury via sponging microRNA-21-5p."	hsa_circ_0068888 	"circ_0068,888 "	hsa_circ_WHSC1	WHSC1	sepsis-associated acute kidney injury 	MONDO:0005229	bacterial infectious disease with sepsis	down-regulated	RT-qPCR	"hsa_circ_0068,888 is down-regulated in LPS-induced HK-2 cell injury and was previously reported as down-regulated in plasma from patients with sepsis-associated AKI. In vitro, hsa_circ_0068,888 overexpression protects HK-2 cells by improving viability and reducing inflammation, oxidative stress, and NF-kB activation. Mechanistically, it sponges miR-21e5p, and miR-21e5p overexpression reverses the protective effects of hsa_circ_0068,888."	0.5607
33433717	Archives of dermatological research	2021	Circular RNA hsa_Circ_0005795 mediates cell proliferation of cutaneous basal cell carcinoma via sponging miR-1231.	hsa_circ_0005795	Circ_0005795	hsa_circ_LPXN		cutaneous basal cell carcinoma 	MONDO:0020804	basal cell carcinoma	up-regulated	RT-qPCR	Circ_0005795 is up-regulated in BCC tissues and cell lines and acts as an oncogenic circRNA. It is mainly localized in the cytoplasm and promotes BCC cell proliferation and colony formation while inhibiting apoptosis by sponging miR-1231 and modulating anti-apoptotic factors such as Bcl-2 and Bcl-xl. The study proposes Circ_0005795 as a potential diagnostic biomarker and therapeutic target for BCC.	0.6777
33433801	Digestive diseases and sciences	2021	Circular RNA circZFR Promotes Hepatocellular Carcinoma Progression by Regulating miR-375/HMGA2 Axis.	hsa_circ_0072088	circZFR 	hsa_circ_ZFR	ZFR	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circZFR is up-regulated in HCC tissues and cell lines and functions as an oncogenic circRNA. Mechanistically, circZFR sponges miR-375 to increase HMGA2 expression, thereby promoting glycolysis, proliferation and tumor growth while suppressing apoptosis. Its high expression is associated with TNM stage, tumor size and HBV status, suggesting potential clinical relevance in HCC."	0.7785
33433806	Digestive diseases and sciences	2021	Lidocaine Inhibits Hepatocellular Carcinoma Development by Modulating circ_ITCH/miR-421/CPEB3 Axis.	hsa_circ_0059961	circ_ITCH 	hsa_circ_ITCH	ITCH	hepatocellular carcinoma	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"circ_ITCH is down-regulated in hepatocellular carcinoma tissues and cells and is restored by lidocaine treatment. In lidocaine-treated HCC models, circ_ITCH suppresses proliferation, migration, invasion, and xenograft tumor growth while promoting apoptosis, at least partly through the circ_ITCH/miR-421/CPEB3 ceRNA axis."	0.742
33439448	Molecular and cellular biochemistry	2021	Astragaloside IV alleviates atherosclerosis through targeting circ_0000231/miR-135a-5p/CLIC4 axis in AS cell model in vitro.	hsa_circ_0000231	circular RNA_0000231 	hsa_circ_ARHGAP12	ARHGAP12	atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"In an ox-LDL-induced HUVEC atherosclerosis cell model, circ_0000231 was up-regulated and promoted endothelial cell injury, including apoptosis, inflammation, oxidative stress and impaired migration/viability. Mechanistically, circ_0000231 sponged miR-135a-5p to regulate CLIC4, and ASV alleviated cell injury by targeting the circ_0000231/miR-135a-5p/CLIC4 axis."	0.763
33449226	Digestive diseases and sciences	2021	Circ_0004104 Accelerates the Progression of Gastric Cancer by Regulating the miR-539-3p/RNF2 Axis.	hsa_circ_0004104	circ_0004104	hsa_circ_SPARC	SPARC	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_0004104 is up-regulated in gastric cancer tissues and cell lines, and high expression is associated with advanced clinical features and poor prognosis. Functionally, circ_0004104 promotes proliferation, migration, invasion, glutaminolysis, and in vivo tumor growth. Mechanistically, it sponges miR-539-3p to positively regulate RNF2 expression, forming a circ_0004104/miR-539-3p/RNF2 axis."	0.7646
33449227	Digestive diseases and sciences	2021	Plasma Exosomal CircNEK9 Accelerates the Progression of Gastric Cancer via miR-409-3p/MAP7 Axis.	hsa_circ_0032683	CircNEK9 	hsa_circ_NEK9	NEK9	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"CircNEK9 is up-regulated in gastric cancer tissues, cell lines, and plasma exosomes. It promotes GC proliferation, cell cycle progression, migration, invasion, metastasis, and xenograft tumor growth by sponging miR-409-3p and up-regulating MAP7. Plasma exosomal circNEK9 may serve as a diagnostic or therapeutic marker and enhances malignant motility of recipient GC cells."	0.78
33450597	International immunopharmacology	2021	Expression and clinical significance of circular RNAs related to immunity and inflammation in patients with rheumatoid arthritis.	hsa_circ_0003353	hsa_-circ_0003353 			rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0003353 is up-regulated in PBMCs from RA patients and in RA-FLS, especially after TNF-alpha stimulation. Functional assays indicate that it promotes inflammatory cytokine production, proliferation, migration and invasion of RA-FLS while inhibiting apoptosis, and it may serve as a diagnostic biomarker for RA."	0.6758
33450597	International immunopharmacology	2021	Expression and clinical significance of circular RNAs related to immunity and inflammation in patients with rheumatoid arthritis.	hsa_circ_0005732	hsa_-circ_0005732 			rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0005732 is down-regulated in PBMCs from RA patients and was validated by RT-qPCR. It showed diagnostic potential in ROC analysis and correlated with several clinical indicators and patient-reported outcome measures.	0.5047
33450597	International immunopharmacology	2021	Expression and clinical significance of circular RNAs related to immunity and inflammation in patients with rheumatoid arthritis.	hsa_circ_0072428	hsa_-circ_0072428 			rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0072428 is down-regulated in PBMCs from RA patients and was validated by RT-qPCR. It showed diagnostic potential in ROC analysis and correlated positively with GH and RF.	0.5047
33450597	International immunopharmacology	2021	Expression and clinical significance of circular RNAs related to immunity and inflammation in patients with rheumatoid arthritis.	hsa_circ_0091685	hsa_-circ_0091685 			rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0091685 is up-regulated in PBMCs from RA patients and was validated by RT-qPCR. Unlike the other confirmed circRNAs, the study reported no correlation between hsa_circ_0091685 and clinical indicators, and no clear risk factors were identified."	0.4032
33459380	Journal of cellular physiology	2021	FUS-induced circular RNA ZNF609 promotes tumorigenesis and progression via sponging miR-142-3p in lung cancer.	hsa_circ_0000615	circZNF609 	hsa_circ_ZNF609	ZNF609	lung cancer 	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circZNF609 is up-regulated in lung cancer tissues and cell lines and acts as an oncogenic circRNA. FUS promotes circZNF609 biogenesis, and circZNF609 promotes proliferation, migration, and xenograft tumor growth while inhibiting apoptosis through the miR-142-3p/GNB2 axis."	0.8747
33465495	"Clinical immunology (Orlando, Fla.)"	2021	Peripheral blood hsa-circRNA5333-4: A novel biomarker for myasthenia gravis.		hsa-circRNA5333-4 	hsa_circ_APOBEC3C	APOBEC3C	myasthenia gravis 	MONDO:0009688	myasthenia gravis	up-regulated	RT-qPCR; Microarray	"hsa-circRNA5333-4 is up-regulated in peripheral blood from MG patients and was validated across independent cohorts as a diagnostic and monitoring biomarker. It showed the strongest reported diagnostic performance and correlation with qMG score, and bioinformatics predicted a hsa-circRNA5333-4/hsa-miR-4310/MORF4L2 ceRNA axis."	0.5047
33465495	"Clinical immunology (Orlando, Fla.)"	2021	Peripheral blood hsa-circRNA5333-4: A novel biomarker for myasthenia gravis.	hsa_circ_0076490				myasthenia gravis 	MONDO:0009688	myasthenia gravis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0076490 is up-regulated in peripheral blood from MG patients and was validated by qPCR after microarray screening. It showed diagnostic potential by ROC analysis and a moderate correlation with qMG score, but no specific molecular mechanism was experimentally defined."	0.4679
33465495	"Clinical immunology (Orlando, Fla.)"	2021	Peripheral blood hsa-circRNA5333-4: A novel biomarker for myasthenia gravis.	hsa_circ_0047056				myasthenia gravis 	MONDO:0009688	myasthenia gravis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0047056 was identified by microarray and validated by qPCR as up-regulated in peripheral blood of MG patients. It was one of four circRNAs consistent with the microarray assay, but was not selected for additional cohort validation because its ROC performance was lower than hsa-circRNA5333-4 and hsa_circ_0076490."	0.4679
33465495	"Clinical immunology (Orlando, Fla.)"	2021	Peripheral blood hsa-circRNA5333-4: A novel biomarker for myasthenia gravis.		hsa-circRNA16293-1			myasthenia gravis 	MONDO:0009688	myasthenia gravis	down-regulated	RT-qPCR; Microarray	"hsa-circRNA16293-1 was identified by microarray and validated by qPCR as down-regulated in peripheral blood of MG patients. It was one of four circRNAs consistent with microarray results, but was not prioritized for later validation because its ROC performance was lower than the two leading candidates."	0.4679
33472087	Journal of invertebrate pathology	2021	Integrative analysis of circRNA/miRNA/mRNA regulatory network reveals the potential immune function of circRNAs in the Bombyx mori fat body.	bmo_circ_0001432	circ_0001432			Bombyx mori nucleopolyhedrosis virus infection 	MONDO:0005583	non-human animal disease	up-regulated	RT-qPCR; RNA-seq	circ_0001432 is up-regulated in BmNPV-infected Bombyx mori fat body at key post-infection time points. The study proposes that it may act as a miRNA sponge for miR-2774c and miR-3406-5p to regulate target genes 778467 and 101745232 and participate in antiviral immune responses.	0.5608
33472087	Journal of invertebrate pathology	2021	Integrative analysis of circRNA/miRNA/mRNA regulatory network reveals the potential immune function of circRNAs in the Bombyx mori fat body.	bmo_circ_0002826	circ_0002826	bmo_circ_101746299	101746299	Bombyx mori nucleopolyhedrosis virus infection 	MONDO:0005583	non-human animal disease	down-regulated	RT-qPCR; RNA-seq	"circ_0002826 is significantly down-regulated in BmNPV-infected Bombyx mori fat body by RT-qPCR. Its host gene 101746299 did not show significant expression variance, and the study discusses that circ_0002826 may not regulate its host gene under this infection condition."	0.3684
33472087	Journal of invertebrate pathology	2021	Integrative analysis of circRNA/miRNA/mRNA regulatory network reveals the potential immune function of circRNAs in the Bombyx mori fat body.	bmo_circ_0003978				Bombyx mori nucleopolyhedrosis virus infection 	MONDO:0005583	non-human animal disease	dysregulated	RT-qPCR; RNA-seq	"circ_0003978 was selected as a medium-abundance circRNA for qRT-PCR validation in BmNPV-infected Bombyx mori fat body. The text supports that its expression pattern was consistent with RNA-seq data, but no specific mechanistic function or regulatory axis was reported for this circRNA."	0.3684
33472512	Journal of receptor and signal transduction research	2022	Silencing of circular RNA PUM1 inhibits clear cell renal cell carcinoma progression through the miR-340-5p/FABP7 axis.		circular RNA PUM1 	hsa_circ_PUM1	PUM1	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR	"CircPUM1 is up-regulated in ccRCC tissues and cell lines. It promotes malignant progression by sponging miR-340-5p, thereby increasing FABP7 expression and activating the MEK/ERK pathway; CircPUM1 knockdown suppresses proliferation, migration and invasion and promotes apoptosis."	0.73
33475233	Environmental toxicology	2021	Hsa_circ_0001073 targets miR-626/LIFR axis to inhibit lung cancer progression.	hsa_circ_0001073	circ_0001073	hsa_circ_ACVR2A	ACVR2A	lung cancer 	MONDO:0008903	lung cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0001073/circ_0001073 is down-regulated in lung cancer cells and functions as a tumor-suppressive circRNA. It inhibits lung cancer cell viability and invasion while promoting apoptosis, at least partly by targeting miR-626 and increasing LIFR expression through the circ_0001073/miR-626/LIFR regulatory axis."	0.7204
33479730	Journal of biochemistry	2021	Circular RNA circNINL promotes breast cancer progression through activating beta-catenin signaling via miR-921/ADAM9 axis.	hsa_circ_0092338	circNINL	hsa_circ_NINL	NINL	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circNINL/hsa_circ_0092338 is up-regulated in breast cancer tissues and cell lines and is associated with malignant clinicopathologic features and poor prognosis. Functionally, circNINL promotes breast cancer cell proliferation and migration while inhibiting apoptosis. Mechanistically, it acts as a miR-921 sponge to regulate ADAM9, leading to activation of b-catenin signaling and increased expression of downstream oncogenes including CCND1, MMP9 and Survivin."	0.8058
33481008	Journal of biochemistry	2021	circGFRA1 affects the sensitivity of triple-negative breast cancer cells to paclitaxel via the miR-361-5p/TLR4 pathway.		circGFRA1	hsa_circ_GFRA1	GFRA1	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"circGFRA1 is up-regulated in paclitaxel-resistant TNBC MDA-MB-231.PR cells and promotes resistance to paclitaxel. Mechanistically, circGFRA1 acts as a sponge for miR-361-5p, leading to increased TLR4 expression; circGFRA1 knockdown restores miR-361-5p, reduces TLR4, inhibits cell viability, promotes apoptosis, and enhances PTX sensitivity in vitro and in xenograft tumors."	0.657
33481227	Genes & genomics	2021	"Knockdown of circPUM1 impedes cell growth, metastasis and glycolysis of papillary thyroid cancer via enhancing MAPK1 expression by serving as the sponge of miR-21-5p."		Circ-Pumilio 1 	hsa_circ_PUM1	PUM1	papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circPUM1 is up-regulated in papillary thyroid cancer tissues and cell lines, and high expression is associated with poorer overall survival. Functionally, circPUM1 promotes PTC cell growth, migration, invasion, glycolysis and in vivo tumorigenesis. Mechanistically, circPUM1 sponges miR-21-5p to regulate MAPK1, forming a circPUM1/miR-21-5p/MAPK1 axis that supports PTC progression."	0.7537
33496921	Biotechnology letters	2021	Circular RNA 0081146 facilitates the progression of gastric cancer by sponging miR-144 and up-regulating HMGB1.	hsa_circ_0081146	Circular RNA 0081146 			gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"Circ_0081146 is up-regulated in gastric cancer tissues, serum and cell lines, and high expression is associated with poorer 5-year overall survival. Functionally, circ_0081146 promotes GC cell growth, proliferation, migration, invasion and xenograft tumor growth. Mechanistically, it acts as a miR-144 sponge to up-regulate HMGB1 expression, forming a circ_0081146/miR-144/HMGB1 regulatory axis."	0.8322
33499704	"Cell cycle (Georgetown, Tex.)"	2021	Circular RNA ITCH suppresses metastasis of gastric cancer via regulating miR-199a-5p/Klotho axis.		circular RNA ITCH 	hsa_circ_ITCH	ITCH	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"circ-ITCH is down-regulated in gastric cancer tissues, cell lines and serum-derived exosomes. It functions as a tumor suppressor by sponging miR-199a-5p and increasing Klotho expression, thereby inhibiting EMT, migration, invasion, metastasis and proliferation. Clinically, low circ-ITCH is associated with invasion depth and circ-ITCH may serve as a biomarker and therapeutic target for gastric cancer."	0.8314
33501755	Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology	2021	Circ-LRP6 mediates epithelial-mesenchymal transition and autophagy in oral squamous cell carcinomas.	hsa_circ_0000378	circ-LRP6 	hsa_circ_LRP6	LRP6	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circ-LRP6 is up-regulated in OSCC tissues and its expression is associated with clinical grade and TNM stage. Functionally, circ-LRP6 promotes OSCC cell migration, invasion, EMT and autophagy, while knockdown of circ-LRP6 suppresses these malignant phenotypes. Mechanistically, autophagy participates in circ-LRP6-mediated EMT, as rapamycin partially rescues the EMT and autophagy inhibition caused by circ-LRP6 silencing."	0.5414
33507122	"Cell cycle (Georgetown, Tex.)"	2021	Upregulated circRNA hsa_circ_0071036 promotes tumourigenesis of pancreatic cancer by sponging miR-489 and predicts unfavorable characteristics and prognosis.	hsa_circ_0071036	hsa_-circ_0071036 	hsa_circ_INPP4B	INPP4B	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; ISH; Microarray	"hsa_circ_0071036 is an INPP4B-derived human circRNA that is upregulated in PDAC tissues and cell lines. It acts as an oncogenic circRNA by sponging miR-489, thereby promoting proliferation, invasion, tumor growth, and PDAC progression while inhibiting apoptosis. Clinically, elevated or positive hsa_circ_0071036 expression is associated with lymph node metastasis, higher PET-CT SUVmax, poor overall survival, and potential diagnostic/prognostic value."	0.8494
33523578	Oral diseases	2022	Identification of circ_0089153/miR-608/EGFR p53 axis in ameloblastoma via MAPK signaling pathway.	hsa_circ_0089153	circ_0089153			ameloblastoma 	MONDO:0017795	ameloblastoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0089153 is upregulated in ameloblastoma and was validated by microarray and RT-qPCR. The study supports a hsa_circ_0089153/hsa-miR-608/EGFR-p53 axis, in which hsa_circ_0089153 sponges hsa-miR-608 and is linked to MAPK-related regulation of tumor progression processes."	0.6676
33523578	Oral diseases	2022	Identification of circ_0089153/miR-608/EGFR p53 axis in ameloblastoma via MAPK signaling pathway.	hsa_circ_0001955				ameloblastoma 	MONDO:0017795	ameloblastoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001955 is an upregulated circRNA in ameloblastoma validated by RT-qPCR in clinical tissue samples. The paper selected it for circRNA-miRNA network analysis, but did not experimentally validate a specific mechanism for this circRNA."	0.5135
33523578	Oral diseases	2022	Identification of circ_0089153/miR-608/EGFR p53 axis in ameloblastoma via MAPK signaling pathway.	hsa_circ_0000517				ameloblastoma 	MONDO:0017795	ameloblastoma	up-regulated	RT-qPCR; Microarray	hsa_circ_0000517 is an upregulated circRNA in ameloblastoma validated by RT-qPCR in clinical tissue samples. The study did not report a specific validated functional mechanism for this circRNA.	0.5135
33523578	Oral diseases	2022	Identification of circ_0089153/miR-608/EGFR p53 axis in ameloblastoma via MAPK signaling pathway.	hsa_circ_0080425				ameloblastoma 	MONDO:0017795	ameloblastoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0080425 is upregulated in ameloblastoma and validated by RT-qPCR. The study predicted that it targets hsa-miR-608, but did not provide direct experimental validation of this interaction."	0.5135
33523578	Oral diseases	2022	Identification of circ_0089153/miR-608/EGFR p53 axis in ameloblastoma via MAPK signaling pathway.	hsa_circ_0001667				ameloblastoma 	MONDO:0017795	ameloblastoma	down-regulated	RT-qPCR; Microarray	hsa_circ_0001667 is downregulated in ameloblastoma and was validated by RT-qPCR in clinical tissue samples. The study did not report a specific validated functional mechanism for this circRNA.	0.5135
33523578	Oral diseases	2022	Identification of circ_0089153/miR-608/EGFR p53 axis in ameloblastoma via MAPK signaling pathway.	hsa_circ_0043278				ameloblastoma 	MONDO:0017795	ameloblastoma	down-regulated	RT-qPCR; Microarray	hsa_circ_0043278 is downregulated in ameloblastoma and was validated by RT-qPCR in clinical tissue samples. The study did not report a specific validated functional mechanism for this circRNA.	0.5135
33524877	Archives of oral biology	2021	Circ_0081572 inhibits the progression of periodontitis through regulating the miR-378h/RORA axis.	hsa_circ_0081572	circ_0081572	hsa_circ_SERPINE1	SERPINE1	periodontitis	MONDO:0005076	periodontitis	down-regulated	RT-qPCR	"Circ_0081572 is down-regulated in gingival tissues from periodontitis patients and in LPS-induced PDLCs. Functionally, circ_0081572 overexpression alleviates LPS-induced PDLC injury by promoting cell viability and suppressing apoptosis, inflammatory cytokine production and oxidative stress. Mechanistically, it acts as a cytoplasmic miR-378h sponge to up-regulate RORA, forming the circ_0081572/miR-378h/RORA axis."	0.8267
33531648	Cancer gene therapy	2021	Circular RNA hsa_circ_0009172 suppresses gastric cancer by regulation of microRNA-485-3p-mediated NTRK3.	hsa_circ_0009172	hsa_circRNA_0009172 			gastric cancer	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0009172 is downregulated in gastric cancer tissues and cell lines, and low expression is associated with poorer patient survival. Functionally, restoring hsa_circ_0009172 suppresses gastric cancer cell proliferation, migration, invasion, EMT, and xenograft growth. Mechanistically, it acts through a hsa_circ_0009172/miR-485-3p/NTRK3 regulatory axis."	0.8066
33534015	Biotechnology letters	2021	Bufalin inhibits the malignant development of non-small cell lung cancer by mediating the circ_0046264/miR-522-3p axis.	hsa_circ_0046264	circ_0046264	hsa_circ_P4HB	P4HB	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	unknown	RT-qPCR	"This study identifies circ_0046264 as a bufalin-responsive tumor-suppressive circRNA in NSCLC cell models. Bufalin increases circ_0046264 expression, and circ_0046264 suppresses NSCLC proliferation, adhesion, migration, invasion and xenograft tumor growth by targeting miR-522-3p."	0.6578
33535081	Experimental and molecular pathology	2021	Circ_AFF2 facilitates proliferation and inflammatory response of fibroblast-like synoviocytes in rheumatoid arthritis via the miR-375/TAB2 axis.	hsa_circ_0001947		hsa_circ_AFF2	AFF2	rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"circ_AFF2 is up-regulated in RA blood samples and FLS-RA cells. It promotes cell cycle progression, proliferation and inflammatory cytokine production while suppressing apoptosis by sponging miR-375 and increasing TAB2 expression. The study proposes circ_AFF2 as a potential diagnostic and therapeutic target for rheumatoid arthritis."	0.7945
33556191	The Prostate	2021	Circular RNA circANKS1B acts as a sponge for miR-152-3p and promotes prostate cancer progression by upregulating TGF-alpha expression.	hsa_circ_0007294	circANKS1B	hsa_circ_ANKS1B	ANKS1B	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circANKS1B is upregulated in prostate cancer tissues and cell lines, and high expression is associated with poor overall survival and adverse clinicopathological features. Functionally, circANKS1B promotes prostate cancer cell migration and invasion by sponging miR-152-3p and increasing TGF-alpha/EGFR expression, indicating potential value as a prognostic biomarker and therapeutic target."	0.6987
33559088	Digestive diseases and sciences	2022	Circ_0091579 Serves as a Tumor-Promoting Factor in Hepatocellular Carcinoma Through miR-1225-5p/PLCB1 Axis.	hsa_circ_0091579	circ_0091579 	hsa_circ_GPC3		Hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"Circ_0091579 is upregulated in HCC tissues and cells and functions as a tumor-promoting circRNA. Its knockdown suppresses HCC cell proliferation, clonogenicity, migration, invasion and xenograft tumor growth while promoting apoptosis. Mechanistically, circ_0091579 sponges miR-1225-5p to increase PLCB1 expression."	0.6542
33560141	Experimental lung research	2021	"Circ_0000735 enhances the proliferation, metastasis and glycolysis of non-small cell lung cancer by regulating the miR-635/FAM83F axis."	hsa_circ_0000735	Circ_0000735	hsa_circ_P2RX1	P2RX1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0000735 is up-regulated in NSCLC tissues and cell lines. It promotes NSCLC proliferation, migration, invasion, glycolysis and tumor growth while suppressing apoptosis, mainly by sponging miR-635 to positively regulate FAM83F. The study suggests circ_0000735 may serve as a promising biomarker and therapeutic target for NSCLC."	0.7799
33561315	Journal of cellular physiology	2021	Circular RNA circHECTD1 facilitates glioma progression by regulating the miR-296-3p/SLC10A7 axis.	hsa_circ_0000375	circHECTD1 	hsa_circ_HECTD1	HECTD1	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR; RNA-seq	"circHECTD1 is up-regulated in human glioma/GBM tissues and glioma cell lines, and high expression is associated with worse overall survival. Functionally, circHECTD1 promotes glioma cell proliferation, invasion and intracranial xenograft growth. Mechanistically, cytoplasmic circHECTD1 sponges miR-296-3p to relieve repression of SLC10A7, forming a circHECTD1/miR-296-3p/SLC10A7 regulatory axis."	0.8244
33563550	Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]	2021	Repression of circRNA_000684 inhibits malignant phenotypes of pancreatic ductal adenocarcinoma cells via miR-145-mediated KLF5.		circRNA_000684 			pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circRNA_000684 is up-regulated in PDAC tissues, plasma, and cell lines, and high expression is associated with more advanced disease features and poorer survival. Functionally, circRNA_000684 promotes PDAC cell proliferation, migration, invasion, angiogenesis, and xenograft tumor growth by sponging miR-145 and increasing KLF5 expression."	0.8308
33570734	Molecular and cellular biochemistry	2021	Exosomal circ_PIP5K1A regulates the progression of non-small cell lung cancer and cisplatin sensitivity by miR-101/ABCC1 axis.	hsa_circ_0014130	circ_PIP5K1A 	hsa_circ_PIP5K1A	PIP5K1A	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_PIP5K1A is upregulated in NSCLC tissues, serum, cells and serum-derived exosomes. It promotes NSCLC progression and cisplatin resistance by sponging miR-101 and increasing ABCC1 expression, while its knockdown suppresses proliferation, migration, invasion and tumor growth and promotes apoptosis and cisplatin sensitivity."	0.78
33591461	Human cell	2021	The novel circular RNA circ-PGAP3 retards cervical cancer growth by regulating the miR-769-5p/p53 axis.	hsa_circ_0106800	circ-PGAP3	hsa_circ_PGAP3	PGAP3	cervical cancer 	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR; RNA-seq	"circ-PGAP3 is downregulated in cervical cancer and low expression is associated with poor prognosis and aggressive clinicopathological features. Mechanistically, p53 transcriptionally induces circ-PGAP3, while cytoplasmic circ-PGAP3 sponges miR-769-5p to increase p53 signaling, thereby suppressing cervical cancer cell proliferation and tumor growth."	0.8632
33591461	Human cell	2021	The novel circular RNA circ-PGAP3 retards cervical cancer growth by regulating the miR-769-5p/p53 axis.		circ-LRIG1	hsa_circ_LRIG1	LRIG1	cervical cancer 	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR; RNA-seq	"circ-LRIG1 was identified during the authors' screening and qRT-PCR validation of differentially expressed circRNAs in cervical cancer tissues, where it was significantly decreased compared with normal tissues. The study did not further investigate its mechanism, biological function, or clinical significance."	0.348
33600863	Life sciences	2021	Effects of circular RNA Ttc3/miR-148a/Rcan2 axis on inflammation and oxidative stress in rats with acute kidney injury induced by sepsis.		CircRNA Ttc3 	rno_circ_Ttc3	Ttc3	sepsis-induced AKI 	MONDO:0005229	bacterial infectious disease with sepsis	down-regulated	RT-qPCR	"CIRC-Ttc3 is down-regulated in renal tissues of CLP-induced sepsis-associated AKI rats. Its overexpression alleviates kidney injury, inflammation, oxidative stress, renal microvascular permeability and apoptosis. Mechanistically, CIRC-Ttc3 functions as a ceRNA for miR-148a to increase Rcan2 expression, suggesting a protective CIRC-Ttc3/miR-148a/Rcan2 axis and potential therapeutic relevance in sepsis-induced AKI."	0.6867
33615474	Journal of cellular physiology	2021	Hsa_circ_0102171 aggravates the progression of cervical cancer through targeting miR-4465/CREBRF axis.	hsa_circ_0102171	circ_0102171 	hsa_circ_KTN1	KTN1	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"hsa_circ_0102171 is up-regulated in cervical cancer tissues and cell lines. It functions as an oncogenic circRNA by sponging miR-4465 and increasing CREBRF expression, thereby promoting proliferation, migration, invasion and xenograft tumor growth while suppressing apoptosis."	0.8442
33619796	The journal of gene medicine	2021	CircVAPA exerts oncogenic property in non-small cell lung cancer by the miR-876-5p/WNT5A axis.	hsa_circ_0006990	circVAPA 	hsa_circ_VAPA	VAPA	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0006990, named circVAPA, is up-regulated in NSCLC tissues and cell lines and high expression predicts poor prognosis. It promotes malignant NSCLC phenotypes by sponging miR-876-5p to increase WNT5A expression, thereby activating Wnt/beta-catenin signaling."	0.817
33619796	The journal of gene medicine	2021	CircVAPA exerts oncogenic property in non-small cell lung cancer by the miR-876-5p/WNT5A axis.	hsa_circ_0046906		hsa_circ_VAPA	VAPA	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0046906 is one of the VAPA-derived circVAPA isoforms screened in NSCLC tissues. It was significantly up-regulated in NSCLC tissues compared with adjacent non-tumor tissues, but the article did not perform further functional or mechanistic assays for this isoform."	0.2995
33619796	The journal of gene medicine	2021	CircVAPA exerts oncogenic property in non-small cell lung cancer by the miR-876-5p/WNT5A axis.	hsa_circ_0046909		hsa_circ_VAPA	VAPA	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0046909 is one of the VAPA-derived circVAPA isoforms screened in NSCLC tissues. It was significantly up-regulated in NSCLC tissues compared with adjacent non-tumor tissues, but the article did not perform further functional or mechanistic assays for this isoform."	0.2995
33620018	Electromagnetic biology and medicine	2021	"Changes in NOTCH1 gene and its regulatory circRNA, hsa_circ_0005986 expression pattern in human gastric adenocarcinoma and human normal fibroblast cell line following the exposure to extremely low frequency magnetic field."	hsa_circ_0005986				gastric adenocarcinoma 	MONDO:0005036	gastric adenocarcinoma	down-regulated	RT-qPCR	"This study examined hsa_circ_0005986 in AGS human gastric adenocarcinoma cells and Hu02 normal fibroblast cells after extremely low-frequency magnetic field exposure. hsa_circ_0005986 was down-regulated after exposure and showed a positive correlation with NOTCH1 expression in tumor cells, while exposure-associated changes in NOTCH1 and hsa_circ_0005986 were proposed to contribute to reduced AGS cell viability."	0.2586
33621591	Life sciences	2021	Down-regulating circular RNA_0004674 delays the progression of oral squamous cell carcinoma through microRNA-377-3p/THBS1 axis.	hsa_circ_0004674				oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"Circ_0004674 is up-regulated in OSCC tissues and cells. Functionally, Circ_0004674 promotes OSCC cell proliferation, migration, invasion and xenograft tumor growth while inhibiting apoptosis. Mechanistically, silencing Circ_0004674 suppresses OSCC aggressiveness by targeting miR-377-3p and reducing THBS1 expression through the Circ_0004674/miR-377-3p/THBS1 axis."	0.8278
33625798	The journal of gene medicine	2021	Inhibition of hsa_circ_0003489 shifts balance from autophagy to apoptosis and sensitizes multiple myeloma cells to bortezomib via miR-874-3p/HDAC1 axis.	hsa_circ_0003489		hsa_circ_CDK8		multiple myeloma 	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR; Microarray	"This study identifies hsa_circ_0003489 as a tumor-promoting circRNA in multiple myeloma. It acts through the miR-874-3p/HDAC1 axis to promote autophagy and proliferation while suppressing apoptosis, thereby reducing sensitivity to bortezomib. Silencing hsa_circ_0003489 shifts MM cells from autophagy toward apoptosis and enhances bortezomib cytotoxicity in vitro and in xenograft models."	0.7052
33629639	Current eye research	2021	Circ_0000527 Promotes Retinoblastoma Progression through Modulating miR-98-5p/XIAP Pathway.	hsa_circ_0000527	circ_0000527	hsa_circ_EMC9		Retinoblastoma 	MONDO:0008380	retinoblastoma	up-regulated	RT-qPCR	"Circ_0000527 is up-regulated in retinoblastoma tissues and cells. It promotes RB progression by enhancing proliferation, migration, invasion and tumor growth while suppressing apoptosis. Mechanistically, circ_0000527 sponges miR-98-5p to increase XIAP expression, suggesting the circ_0000527/miR-98-5p/XIAP axis as a potential therapeutic target."	0.7597
33630215	Digestive diseases and sciences	2022	"Circ_0006948 Contributes to Cell Growth, Migration, Invasion and Epithelial-Mesenchymal Transition in Esophageal Carcinoma."	hsa_circ_0006948	circ_0006948			esophageal carcinoma 	MONDO:0019086	carcinoma of esophagus	up-regulated	RT-qPCR	"Circ_0006948 is up-regulated in esophageal carcinoma tissues and cell lines. It promotes EC cell growth, migration, invasion, EMT and xenograft tumor growth, at least partly by sponging miR-4262 and thereby increasing FNDC3B expression. The study suggests circ_0006948 may have potential value for molecular diagnosis and treatment of EC."	0.7945
33630225	Molecular and cellular biochemistry	2021	"CircKIF2A contributes to cell proliferation, migration, invasion and glycolysis in human neuroblastoma by regulating miR-129-5p/PLK4 axis."	hsa_circ_0129276	CircKIF2A 	hsa_circ_KIF2A	KIF2A	neuroblastoma 	MONDO:0005072	neuroblastoma	up-regulated	RT-qPCR	"CircKIF2A is up-regulated in neuroblastoma tissues and cell lines. It promotes NB cell proliferation, migration, invasion, glycolysis and in vivo tumor growth by sponging miR-129-5p and increasing PLK4 expression. The study suggests circKIF2A as a potential therapeutic target for NB."	0.7936
33634427	Digestive diseases and sciences	2022	Knockdown of circRAD23B Exerts Antitumor Response in Colorectal Cancer via the Regulation of miR-1205/TRIM44 axis.		circRAD23B 	hsa_circ_RAD23B	RAD23B	Colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circRAD23B is up-regulated in colorectal cancer tissues and cells and is associated with TNM stage and metastasis. Functionally, circRAD23B promotes CRC proliferation, cell cycle progression, migration, invasion, and in vivo tumor growth while suppressing apoptosis. Mechanistically, circRAD23B acts as a miR-1205 sponge to up-regulate TRIM44, forming a circRAD23B/miR-1205/TRIM44 axis that supports CRC progression."	0.7595
33635749	The International journal of neuroscience	2023	Silencing of circular RNA circPDE5A suppresses neuroblastoma progression by targeting the miR-362-5p/NOL4L axis.		circRNA phosphodiesterase 5 A (circPDE5A) 	hsa_circ_PDE5A	PDE5A	neuroblastoma 	MONDO:0005072	neuroblastoma	up-regulated	RT-qPCR	"circPDE5A is up-regulated in neuroblastoma tissues and cell lines. It promotes NB malignant progression, including proliferation, migration, invasion, glycolysis and in vivo tumour growth, by sponging miR-362-5p and thereby regulating NOL4L expression. The study suggests circPDE5A as a potential therapeutic target for NB management."	0.7759
33647793	Biochemical and biophysical research communications	2021	Circular RNA circVMA21 ameliorates lipopolysaccharide (LPS)-induced acute kidney injury by targeting the miR-199a-5p/NRP1 axis in sepsis.		circVMA21 	hsa_circ_VMA21		sepsis 	MONDO:0005229	bacterial infectious disease with sepsis	down-regulated	RT-qPCR	"In this in vitro LPS-induced sepsis injury model, circVMA21 was down-regulated in THP-1 cells. Forced circVMA21 expression protected against LPS-induced cell injury by improving cell viability and reducing apoptosis, inflammation, and oxidative stress. Mechanistically, circVMA21 acted as a sponge for miR-199a-5p and regulated NRP1 expression via the circVMA21/miR-199a-5p/NRP1 axis."	0.6253
33650075	Neurochemical research	2021	Gain of circBRAF Represses Glioma Progression by Regulating miR-1290/FBXW7 Axis.		circBRAF 	hsa_circ_BRAF	BRAF	glioma	MONDO:0021042	glioma	down-regulated	RT-qPCR	"circBRAF is down-regulated in glioma tissues and cell lines. Its overexpression suppresses glioma cell viability, cell-cycle progression, migration, invasion, EMT-related marker changes, and xenograft tumor growth by sponging miR-1290 and increasing FBXW7 expression. Clinically, higher circBRAF expression correlates with smaller tumor size/lower WHO grade and better patient survival."	0.7972
33655541	Biotechnology and applied biochemistry	2022	Circular RNA circCLK3 promotes the progression of tongue squamous cell carcinoma via miR-455-5p/PARVA axis.		circCLK3 	hsa_circ_CLK3		tongue squamous cell carcinoma 	MONDO:0000500	tongue squamous cell carcinoma	up-regulated	RT-qPCR	"circCLK3 is up-regulated in TSCC tissues and cell lines and acts as an oncogenic circRNA. It promotes TSCC cell proliferation, migration, invasion, and cell cycle progression by sponging miR-455-5p and upregulating PARVA."	0.7289
33664496	Nature cell biology	2021	Circular RNA-encoded oncogenic E-cadherin variant promotes glioblastoma tumorigenicity through activation of EGFR-STAT3 signalling.	hsa_circ_0039992	circ-E-Cad RNA 	hsa_circ_CDH1		glioblastoma 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; Northern Blot; ISH; RNA-seq	"circ-E-Cad RNA, a CDH1-derived circRNA annotated as hsa_circ_0039992, is up-regulated in GBM and GSCs and encodes the secreted oncogenic protein C-E-Cad. C-E-Cad directly binds EGFR/EGFRvIII through its unique C-terminal sequence and activates EGFR-STAT3, PI3K-AKT and MAPK-ERK signalling to promote stemness, proliferation, invasion, survival and intracranial tumorigenicity. High C-E-Cad expression is associated with poor overall survival, and anti-C-E-Cad antibody treatment enhances anti-EGFR therapeutic effects in GBM xenografts."	0.8978
33675276	Cell biology international	2021	CircKRT1 drives tumor progression and immune evasion in oral squamous cell carcinoma by sponging miR-495-3p to regulate PDL1 expression.	hsa_circ_0026462	CircRNA keratin 1 	hsa_circ_KRT1	KRT1	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"CircKRT1 is up-regulated in OSCC tissues and cells and high expression is associated with poor overall survival. Functionally, circKRT1 promotes OSCC growth, migration, invasion, EMT, tumorigenesis, and immune evasion. Mechanistically, it sponges miR-495-3p to increase PDL1 expression, forming a circKRT1/miR-495-3p/PDL1 regulatory axis."	0.8439
33675278	Cell biology international	2021	c-Myc-induced circ-NOTCH1 promotes aggressive phenotypes of nasopharyngeal carcinoma cells by regulating the miR-34c-5p/c-Myc axis.		circ-NOTCH1	hsa_circ_NOTCH1	NOTCH1	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; ISH	"circ-NOTCH1 is up-regulated in nasopharyngeal carcinoma tissues and cell lines and functions as an oncogenic circRNA. c-Myc induces circ-NOTCH1 by binding the NOTCH1 promoter, while circ-NOTCH1 sponges miR-34c-5p to increase c-Myc expression, thereby promoting NPC cell proliferation, migration, invasion, and angiogenesis."	0.8344
33676964	Experimental eye research	2021	Hsa_circ_0099198 facilitates the progression of retinoblastoma by regulating miR-1287/LRP6 axis.	hsa_circ_0099198	circ_0099198	hsa_circ_TRHDE	TRHDE	Retinoblastoma 	MONDO:0008380	retinoblastoma	up-regulated	RT-qPCR	"hsa_circ_0099198/circ_0099198 is up-regulated in retinoblastoma cells and mainly localized in the cytoplasm. It promotes RB cell proliferation, migration, invasion, cell-cycle progression and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ_0099198 sponges miR-1287 to up-regulate LRP6, forming a circ_0099198/miR-1287/LRP6 regulatory axis with potential therapeutic relevance."	0.7451
33677796	Human cell	2021	Circular RNA circRNA_0000094 sponges microRNA-223-3p and up-regulate F-box and WD repeat domain containing 7 to restrain T cell acute lymphoblastic leukemia progression.	hsa_circ_0000094	circRNA_0000094 			T cell acute lymphoblastic leukemia 	MONDO:0004963	T-cell acute lymphoblastic leukemia	down-regulated	RT-qPCR	"circ_0000094 is down-regulated in T-ALL tissues and cell lines and functions as a tumor-suppressive circRNA. Mechanistically, it is mainly cytoplasmic and sponges miR-223-3p to relieve repression of FBW7, thereby inhibiting T-ALL cell proliferation, migration, invasion, and GSIs resistance while promoting apoptosis. The study suggests circ_0000094 may be a potential therapeutic target for T-ALL."	0.7785
33682697	Cancer biomarkers : section A of Disease markers	2021	"CircRNA_100565 contributes to cisplatin resistance of NSCLC cells by regulating proliferation, apoptosis and autophagy via miR-337-3p/ADAM28 axis."		circRNA_100565 	hsa_circ_MLLT10	MLLT10	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circRNA_100565 is up-regulated in NSCLC, especially in DDP-resistant tissues and cells, and high expression predicts poor overall survival. Functionally, circRNA_100565 promotes cisplatin resistance by enhancing proliferation and autophagy while suppressing apoptosis. Mechanistically, it acts through a circRNA_100565/miR-337-3p/ADAM28 axis and its knockdown increases DDP sensitivity in vitro and in xenograft tumors."	0.8586
33684690	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2021	Curcumin suppresses the malignancy of non-small cell lung cancer by modulating the circ-PRKCA/miR-384/ITGB1 pathway.	hsa_circ_0007580	circ-PRKCA	hsa_circ_PRKCA	PRKCA	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0007580/circ-PRKCA is up-regulated in NSCLC tissues and cells and promotes malignant phenotypes. Curcumin suppresses NSCLC progression by downregulating circ-PRKCA, thereby relieving miR-384-mediated repression of ITGB1 and reducing viability, colony formation, migration, invasion, and xenograft tumor growth while increasing apoptosis."	0.742
33684877	International immunopharmacology	2021	"Circ_0134111 knockdown relieves IL-1beta-induced apoptosis, inflammation and extracellular matrix degradation in human chondrocytes through the circ_0134111-miR-515-5p-SOCS1 network."	hsa_circ_0134111	circ_0134111	hsa_circ_PDE1C	PDE1C	Osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circ_0134111 is up-regulated in OA cartilage tissues and IL-1beta-induced human chondrocytes. Functionally, circ_0134111 knockdown restores proliferation and alleviates apoptosis, inflammation and ECM degradation in the OA cell model. Mechanistically, circ_0134111 acts as a miR-515-5p sponge to increase SOCS1 expression through the circ_0134111-miR-515-5p-SOCS1 network."	0.7944
33685301	Autoimmunity	2021	Hsa_circ_0056558 regulates cyclin-dependent kinase 6 by sponging microRNA-1290 to suppress the proliferation and differentiation in ankylosing spondylitis.	hsa_circ_0056558	circ_0056558 			ankylosing spondylitis 	MONDO:0005306	ankylosing spondylitis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0056558 is up-regulated in ankylosing spondylitis tissues and fibroblast cells. It acts as a cytoplasmic ceRNA that sponges miR-1290 to increase CDK6 expression, thereby suppressing fibroblast proliferation and differentiation, promoting apoptosis and inflammatory factor expression, and activating the PI3K/AKT/NF-jB pathway. The study suggests hsa_circ_0056558 as a potential therapeutic target for AS."	0.7489
33686422	Acta biochimica et biophysica Sinica	2021	Circ_002059 suppresses cell proliferation and migration of gastric cancer via miR-182/MTSS1 axis.		circ_002059 			gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"Circ_002059 is down-regulated in gastric cancer contexts and functions as a tumor suppressor. It inhibits GC cell proliferation, migration, and xenograft tumor growth by sponging miR-182 and thereby increasing MTSS1 expression."	0.6253
33687619	Journal of bioenergetics and biomembranes	2021	Circ_0074027 contributes to non-small cell lung cancer progression through positively modulating RHOA via sequestering miR-2467-3p.	hsa_circ_0074027		hsa_circ_PITX1	PITX1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"Circ_0074027 is up-regulated in NSCLC tissues and cell lines and functions as an oncogenic circRNA. It promotes NSCLC proliferation, migration, invasion, EMT and xenograft tumor growth while suppressing apoptosis, mainly by sponging miR-2467-3p to enhance RHOA expression."	0.7595
33709381	Genes & genomics	2021	CircRNA circ_0067772 aggravates the malignant progression of cutaneous squamous cell carcinoma by regulating miR-1238-3p/FOXG1 axis.	hsa_circ_0067772	circ_0067772	hsa_circ_SLC33A1	SLC33A1	cutaneous squamous cell carcinoma 	MONDO:0002529	skin squamous cell carcinoma	up-regulated	RT-qPCR	"circ_0067772 is upregulated in CSCC tissues and cells and functions as an oncogenic circRNA. It promotes CSCC proliferation, migration, invasion, cell cycle progression, metastasis, and xenograft tumor growth while suppressing apoptosis, mainly through sponging miR-1238-3p to upregulate FOXG1. The study suggests circ_0067772 as a potential therapeutic target for CSCC."	0.6545
33710445	Inflammation	2021	Circ_0085289 Alleviates the Progression of Periodontitis by Regulating let-7f-5p/SOCS6 Pathway.	hsa_circ_0085289	circ_0085289	hsa_circ_CTHRC1	CTHRC1	periodontitis	MONDO:0005076	periodontitis	down-regulated	RT-qPCR	"hsa_circ_0085289/circ_0085289 is down-regulated in periodontitis PDL tissues and LPS-treated PDLCs. Its overexpression alleviates inflammatory injury by reducing TNF-alpha, IL-6 and IL-1beta release, restoring PDLC viability, and inhibiting apoptosis. Mechanistically, circ_0085289 sponges let-7f-5p to up-regulate SOCS6, forming a circ_0085289/let-7f-5p/SOCS6 ceRNA axis with potential therapeutic biomarker relevance in periodontitis."	0.7277
33713752	Virus research	2021	Porcine circovirus type 2 infection activates NF-kappaB pathway and cellular inflammatory responses through circPDCD4/miR-21/PDCD4 axis in porcine kidney 15 cell.		Sus-PDCD4_0012 	ssc_circ_PDCD4	PDCD4	porcine circovirus type 2 infection 	MONDO:0024990	swine disease	down-regulated	RT-qPCR	"In PCV2-infected PK-15 cells, circPDCD4 is down-regulated and functions as a ceRNA/miR-21 sponge. Restoring circPDCD4 reduces miR-21 levels, counteracts miR-21-driven NF-kappaB activation, and decreases inflammatory cytokine production through the circPDCD4/miR-21/PDCD4 axis."	0.7322
33714984	Oncogene	2021	CircHIF1A regulated by FUS accelerates triple-negative breast cancer progression by modulating NFIB expression and translocation.	hsa_circ_0004623	circHIF1A	hsa_circ_HIF1A	HIF1A	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; ISH	"circHIF1A is a HIF1A-derived human circRNA upregulated in breast cancer and TNBC, where high expression is associated with lymph node metastasis, TNBC subtype and poor overall survival. It promotes TNBC proliferation, migration, metastasis and tumor growth by sponging miR-149-5p, increasing NFIB expression and nuclear translocation, activating AKT/STAT3 signaling and repressing P21, while FUS and NFIB form a positive feedback loop that enhances circHIF1A biogenesis. circHIF1A is also secreted in exosomes and elevated in patient plasma, supporting its potential as a diagnostic biomarker and therapeutic target."	0.9043
33719821	Immunopharmacology and immunotoxicology	2021	Circular RNA circ_0003420 mediates inflammation in sepsis-induced liver damage by downregulating neuronal PAS domain protein 4.	hsa_circ_0003420	circ_0003420			sepsis-induced liver damage 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR; Microarray	"circ_0003420 is upregulated in liver tissues from sepsis patients and in LPS-treated Kupffer cells. It promotes LPS-induced cell injury, apoptosis, and inflammatory cytokine responses by directly targeting and downregulating NPAS4 mRNA, suggesting a potential therapeutic target for sepsis-induced liver damage."	0.7404
33722777	Clinics and research in hepatology and gastroenterology	2021	Circular RNA circAFF2 accelerates gastric cancer development by activating miR-6894-5p and regulating ANTXR 1 expression.		circular RNA AFF2 	hsa_circ_AFF2	AFF2	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circAFF2 is up-regulated in gastric cancer tissues, plasma, and cell lines. It promotes GC cell proliferation, migration, invasion, and xenograft tumor growth by sponging miR-6894-5p and relieving repression of ANTXR1. Its expression is associated with tumor invasion depth, TNM stage, and tumor size, suggesting biomarker and therapeutic-target potential."	0.8314
33725240	Digestive diseases and sciences	2022	Circ_0023984 Facilitates Esophageal Squamous Cell Carcinoma Progression by Regulating miR-433-3p/REV3L Axis.	hsa_circ_0023984	circ_0023984	hsa_circ_NOX4	NOX4	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"Circ_0023984 is up-regulated in ESCC tissues and cells and acts as an oncogenic circRNA. It promotes ESCC cell proliferation, migration, invasion and xenograft tumor growth while suppressing apoptosis, mainly by sponging miR-433-3p to increase REV3L expression. The study suggests circ_0023984 as a potential therapeutic target for ESCC."	0.84
33725570	Biochemical and biophysical research communications	2021	Hsa_circ_001659 serves as a novel diagnostic and prognostic biomarker for colorectal cancer.		hsa_circ_001659 	hsa_circ_SOX13	SOX13	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circ_001659 is up-regulated in serum from CRC patients and shows diagnostic value, including for early-stage and CEA-negative CRC. Functionally, it promotes CRC cell migration, invasion and metastasis. Mechanistically, nuclear circ_001659 interacts with RBBP5 and recruits it to the Vimentin promoter, increasing H3K4 trimethylation and activating Vimentin transcription."	0.8913
33725572	Biochemical and biophysical research communications	2021	circ0000069 promotes cervical cancer cell proliferation and migration by inhibiting miR-4426.	hsa_circ_0000069	circ0000069	hsa_circ_STIL	STIL	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000069/circ0000069 is upregulated in cervical cancer cells and tissues and shows diagnostic potential by ROC analysis. m6A modification, involving METTL3-dependent regulation, maintains circ0000069 stability, and circ0000069 promotes proliferation, migration, and xenograft tumor growth by sponging miR-4426."	0.8712
33734482	Biotechnology and applied biochemistry	2022	CircRNA circ_0006892 regulates miR-24/PHLPP2 axis to mitigate cigarette smoke extract-induced bronchial epithelial cell injury.	hsa_circ_0006892	circ_0006892	hsa_circ_PI4KB	PI4KB	Chronic obstructive pulmonary disease 	MONDO:0005002	chronic obstructive pulmonary disease	down-regulated	RT-qPCR	"In COPD-related cigarette smoke extract injury models, circ_0006892 is down-regulated in patient lung tissues and CSE-treated bronchial epithelial cells. Functional experiments indicate that circ_0006892 has a protective role by reducing apoptosis and inflammatory cytokine secretion, likely through sponging miR-24 and increasing PHLPP2 expression."	0.7968
33735626	Biochemical and biophysical research communications	2021	Circular RNA circ_0005774 contributes to proliferation and suppresses apoptosis of acute myeloid leukemia cells via circ_0005774/miR-192-5p/ULK1 ceRNA pathway.	hsa_circ_0005774	circ_0005774			acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"circ_0005774 is up-regulated in pediatric AML blood samples and AML cell lines. Functionally, circ_0005774 promotes proliferation and cell cycle progression while suppressing apoptosis, at least partly through the circ_0005774/miR-192e5p/ULK1 ceRNA axis."	0.7032
33737085	Life sciences	2021	The mechanism of aerobic exercise combined with glucosamine therapy and circUNK in improving knee osteoarthritis in rabbits.	hsa_circ_0045714	circUNK 	hsa_circ_UNK	UNK	knee osteoarthritis 	MONDO:0005416	"osteoarthritis, knee"	down-regulated	RT-qPCR	"circUNK was down-regulated in rabbit knee OA cartilage tissues and MIA-induced osteoarthritis chondrocytes. Overexpression of circUNK protected chondrocytes by improving viability/proliferation, suppressing apoptosis, and modulating cartilage differentiation- and apoptosis-related genes, while aerobic exercise plus glucosamine up-regulated circUNK during OA improvement."	0.421
33738908	Hepatology research : the official journal of the Japan Society of Hepatology	2021	Circular ribonucleic acid nei-like deoxyribonucleic acid glycosylase 3 governs the microribonucleic acid -3150b-3p/laminin subunit gamma 1 network to partially promote the development of hepatocellular carcinoma.	hsa_circ_0001459	circular RNA nei-like DNA glycosylase 3 	hsa_circ_NEIL3	NEIL3	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circNEIL3 (hsa_circ_0001459), derived from NEIL3, is up-regulated in HCC tumor tissues and cell lines and mainly localizes to the cytoplasm. It promotes HCC cell proliferation, migration, invasion, cell-cycle progression, and in vivo tumor growth while suppressing apoptosis. Mechanistically, circNEIL3 functions as a ceRNA for miR-3150b-3p to indirectly increase LAMC1 expression, forming a circNEIL3/miR-3150b-3p/LAMC1 regulatory network."	0.8175
33749508	"Cell cycle (Georgetown, Tex.)"	2021	Circular RNA SMARCA5 functions as an anti-tumor candidate in colon cancer by sponging microRNA-552.		circSMARCA5 	hsa_circ_SMARCA5	SMARCA5	colon cancer	MONDO:0021063	malignant colon neoplasm	down-regulated	RT-qPCR	"circSMARCA5 is down-regulated in colon cancer tissues and functions as a tumor suppressor. Its overexpression inhibits colon cancer cell growth, migration, invasion and xenograft tumor growth, promotes apoptosis, and acts mechanistically by sponging miR-552 to block Wnt and YAP1 pathway activation."	0.6544
33751650	Biotechnology and applied biochemistry	2022	CircSEC24A promotes IL-1beta-induced apoptosis and inflammation in chondrocytes by regulating miR-142-5p/SOX5 axis.	hsa_circ_0005105	circSEC24A 	hsa_circ_SEC24A		osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circSEC24A is up-regulated in OA cartilage tissues, OA chondrocytes, and IL-1beta-treated chondrocytes. It aggravates OA-like chondrocyte injury by inhibiting proliferation and promoting apoptosis and inflammatory factor expression, acting through a circSEC24A/miR-142-5p/SOX5 ceRNA axis."	0.7032
33755879	Molecular and cellular biochemistry	2021	Circ_0023028 contributes to the progression of laryngeal squamous cell carcinoma by upregulating LASP1 through miR-486-3p.	hsa_circ_0023028	circ_0023028	hsa_circ_C11orf80	C11orf80	laryngeal squamous cell carcinoma 	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR	"circ_0023028 is upregulated in LSCC tissues and cell lines and is associated with advanced tumor stage. Functionally, circ_0023028 promotes malignant LSCC phenotypes including proliferation, invasion, migration, cell-cycle progression and xenograft tumor growth, while inhibiting apoptosis. Mechanistically, circ_0023028 acts as a ceRNA for miR-486-3p to increase LASP1 expression, forming a circ_0023028/miR-486-3p/LASP1 regulatory axis."	0.795
33763840	Journal of molecular neuroscience : MN	2021	"CircPITX1 Regulates Proliferation, Angiogenesis, Migration, Invasion, and Cell Cycle of Human Glioblastoma Cells by Targeting miR-584-5p/KPNB1 Axis."	hsa_circ_0074027	circPITX1	hsa_circ_PITX1	PITX1	glioblastoma 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; Microarray	"circPITX1 is up-regulated in glioblastoma tissues and cells and acts as an oncogenic circRNA. It promotes GBM cell proliferation, angiogenesis, migration, invasion, cell cycle progression, and xenograft tumor growth by sponging miR-584-5p and regulating KPNB1 expression. The study suggests the circPITX1/miR-584-5p/KPNB1 axis may have diagnostic relevance for GBM patients."	0.8511
33769559	European journal of clinical investigation	2021	CircRUNX1 functions as an oncogene in colorectal cancer by regulating circRUNX1/miR-485-5p/SLC38A1 axis.		circRUNX1 	hsa_circ_RUNX1	RUNX1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circRUNX1 is up-regulated in colorectal cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes CRC cell colony formation, migration, invasion, tumour growth and glutamine metabolism while suppressing apoptosis through the circRUNX1/miR-485-5p/SLC38A1 axis. Its expression is associated with lymph node metastasis and TNM stage, suggesting potential prognostic biomarker value."	0.7595
33771636	Genomics	2021	CircRNA expression profile and functional analysis in retinal ischemia-reperfusion injury.	mmu_circ_0004845		mmu_circ_Wdr37	Wdr37	retinal ischemia-reperfusion injury 	MONDO:0005203	ischemia reperfusion injury	up-regulated	Microarray	"Mouse cWdr37/mmu_circ_0004845 is up-regulated in retinal I/R injury. Silencing cWdr37 protects retinal ganglion cells from hypoxic or oxidative stress and alleviates retinal neurodegeneration, reactive gliosis, and apoptosis in vivo, suggesting a pathogenic role and therapeutic potential."	0.5679
33771636	Genomics	2021	CircRNA expression profile and functional analysis in retinal ischemia-reperfusion injury.	hsa_circ_0017444	cWDR37	hsa_circ_WDR37	Wdr37	cataract	MONDO:0005129	cataract	up-regulated	RT-qPCR	"Human cWDR37/hsa_circ_0017444 is a homolog of mouse cWdr37 and is significantly increased in aqueous humor from glaucoma patients compared with cataract controls. Its aqueous humor level showed strong diagnostic performance for glaucoma, suggesting biomarker potential."	0.4187
33771636	Genomics	2021	CircRNA expression profile and functional analysis in retinal ischemia-reperfusion injury.	hsa_circ_0017444	cWDR37	hsa_circ_WDR37	Wdr37	cataract	MONDO:0005129	cataract	up-regulated	RT-qPCR	"Human cWDR37/hsa_circ_0017444 is a homolog of mouse cWdr37 and is significantly increased in aqueous humor from glaucoma patients compared with cataract controls. Its aqueous humor level showed strong diagnostic performance for glaucoma, suggesting biomarker potential."	0.4187
33783904	The journal of gene medicine	2021	Circular RNA hsa_circ_0005397 promotes hepatocellular carcinoma progression by regulating the miR-326/PDK2 axis.	hsa_circ_0005397	circRHOT1	hsa_circ_RHOT1	RHOT1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0005397 is up-regulated in HCC tissues and cell lines and high expression predicts poor survival. Functionally, it promotes HCC progression by enhancing proliferation, migration, invasion, metastasis and tumor growth while suppressing apoptosis. Mechanistically, hsa_circ_0005397 sponges miR-326 to up-regulate PDK2, forming the hsa_circ_0005397/miR-326/PDK2 axis."	0.8351
33789319	Urologia internationalis	2021	Identification of circRNA-miRNA-mRNA Regulatory Network in Bladder Cancer by Integrated Analysis.	hsa_circ_0008035				Bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; Microarray	hsa_circ_0008035 was downregulated in bladder cancer in integrated analysis and qRT-PCR validation. The study proposes that it may act as a ceRNA sponge for hsa-miR-107 to regulate MSRB3 in BC.	0.4032
33789319	Urologia internationalis	2021	Identification of circRNA-miRNA-mRNA Regulatory Network in Bladder Cancer by Integrated Analysis.	hsa_circ_0028173				Bladder cancer 	MONDO:0004986	urinary bladder carcinoma	dysregulated	Microarray	"hsa_circ_0028173 was identified as dysregulated in bladder cancer, with integrated analysis suggesting upregulation but qRT-PCR showing an inconsistent trend. The study proposes a possible hsa_circ_0028173/hsa-miR-338-3p/TPX2/GATA3 ceRNA axis, but states that its exact role in BC requires further study."	0.4032
33789319	Urologia internationalis	2021	Identification of circRNA-miRNA-mRNA Regulatory Network in Bladder Cancer by Integrated Analysis.	hsa_circ_0000144				Bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0000144 was downregulated in bladder cancer according to integrated analysis, and this expression pattern was generally confirmed by qRT-PCR. The paper did not define a bladder-cancer-specific interaction axis or functional mechanism for this circRNA."	0.4032
33789319	Urologia internationalis	2021	Identification of circRNA-miRNA-mRNA Regulatory Network in Bladder Cancer by Integrated Analysis.	hsa_circ_0082582				Bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	Microarray	hsa_circ_0082582 was identified from GEO circRNA expression data as the most upregulated differentially expressed circRNA in bladder cancer. The study did not report qRT-PCR validation or a specific regulatory mechanism for this circRNA.	0.1768
33789319	Urologia internationalis	2021	Identification of circRNA-miRNA-mRNA Regulatory Network in Bladder Cancer by Integrated Analysis.	hsa_circ_0023642				Bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	Microarray	hsa_circ_0023642 was identified from GEO circRNA expression data as the most downregulated differentially expressed circRNA in bladder cancer. The study did not report qRT-PCR validation or a specific regulatory mechanism for this circRNA.	0.1768
33797091	European journal of clinical investigation	2021	Circ_0007142 downregulates miR-874-3p-mediated GDPD5 on colorectal cancer cells.	hsa_circ_0007142	Circ_0007142	hsa_circ_DOCK1	DOCK1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"Circ_0007142 is up-regulated in CRC tissues and cells and functions as an oncogenic circRNA. It sponges miR-874-3p to increase GDPD5 expression, thereby promoting CRC proliferation and tumorigenesis while inhibiting apoptosis and ferroptosis. Knockdown of circ_0007142 suppresses tumour growth in a cell line-derived xenograft model and may improve CRC therapy by enhancing ferroptosis."	0.7404
33797132	Biotechnology and applied biochemistry	2022	Green tea polyphenols inhibit malignant melanoma progression via regulating circ_MITF/miR-30e-3p/HDAC2 axis.		circ_MITF 	hsa_circ_MITF	MITF	malignant melanoma 	MONDO:0005105	melanoma	up-regulated	RT-qPCR	"circ_MITF is up-regulated in melanoma tissues and cell lines and is suppressed by GTP treatment. Functionally, circ_MITF promotes malignant melanoma phenotypes and weakens GTP-mediated anticancer effects by sponging miR-30e-3p and increasing HDAC2 expression. Higher circ_MITF expression is associated with advanced TNM stage."	0.7799
33811842	Brain research	2021	CircABCC3 knockdown inhibits glioblastoma cell malignancy by regulating miR-770-5p/SOX2 axis through PI3K/AKT signaling pathway.		circABCC3 	hsa_circ_ABCC3		glioblastoma	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR	"CircABCC3 is up-regulated in glioblastoma tissues and cells and is associated with more advanced TNM stage. Functionally, circABCC3 promotes glioblastoma proliferation, migration, invasion, angiogenesis-like tube formation and in vivo tumor growth while suppressing apoptosis. Mechanistically, it sponges miR-770-5p to regulate SOX2 and activate the PI3K/AKT pathway, supporting its role as a potential therapeutic target."	0.7795
33818788	Drug development research	2021	CircFAT1 facilitates cervical cancer malignant progression by regulating ERK1/2 and p38 MAPK pathway through miR-409-3p/CDK8 axis.	hsa_circ_0001461	circFAT1	hsa_circ_FAT1	FAT1	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"CircFAT1 is up-regulated in cervical cancer tissues and cell lines and high expression predicts poor survival. Functionally, circFAT1 promotes proliferation, migration, invasion and xenograft tumor growth while suppressing apoptosis. Mechanistically, it acts as a sponge for miR-409-3p to relieve repression of CDK8 and activate ERK1/2 and p38 MAPK signaling."	0.7754
33819576	"Clinical immunology (Orlando, Fla.)"	2021	Circ_0001103 alleviates IL-1beta-induced chondrocyte cell injuries by upregulating SIRT1 via targeting miR-375.	hsa_circ_0001103	circ_0001103	hsa_circ_SERPINE2	SERPINE2	Osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR	"circ_0001103 is downregulated in OA cartilage tissues, OA serum samples, and IL-1beta-treated human chondrocytes. Its overexpression protects chondrocytes from IL-1beta-induced injury by inhibiting apoptosis, inflammation, and ECM degradation. Mechanistically, circ_0001103 sponges miR-375 to increase SIRT1 expression, suggesting potential biomarker value in OA pathogenesis."	0.7759
33821441	Human cell	2021	Circular RNA circ-PTEN elevates PTEN inhibiting the proliferation of non-small cell lung cancer cells.	hsa_circ_0094342	circ-PTEN 	hsa_circ_PTEN	PTEN	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"Circ-PTEN (hsa_circ_0094342), a PTEN-derived circRNA, is down-regulated in NSCLC tissues and serum and its low expression is associated with malignant clinicopathological features and poor outcome. Functionally, circ-PTEN suppresses NSCLC cell proliferation and xenograft tumor growth. Mechanistically, DHX9 reduces circ-PTEN production, while circ-PTEN sponges miR-155 and miR-330-3p to increase PTEN expression and inhibit PI3K/AKT signaling, supporting its potential diagnostic, prognostic and therapeutic value."	0.8554
33821559	Addiction biology	2021	Circular RNA expression alteration identifies a novel circulating biomarker in serum exosomal for detection of alcohol dependence.	hsa_circ_0004771				Alcohol dependence 	MONDO:0007079	alcohol dependence	dysregulated	RT-qPCR; RNA-seq	"Serum exosomal hsa_circ_0004771 was dysregulated in alcohol dependence and validated by qRT-PCR. Its level positively correlated with SADQ and ADS severity scores and showed diagnostic potential for distinguishing AD patients from controls, with a proposed miRNA-related inflammatory mechanism."	0.559
33821559	Addiction biology	2021	Circular RNA expression alteration identifies a novel circulating biomarker in serum exosomal for detection of alcohol dependence.	hsa_circ_0002130				Alcohol dependence 	MONDO:0007079	alcohol dependence	dysregulated	RT-qPCR; RNA-seq	hsa_circ_0002130 was identified as one of the top differentially expressed serum exosomal circRNAs in AD and was significantly validated by qRT-PCR. The study suggests that such dysregulated circRNAs may participate in AD pathogenesis through miRNA-related regulatory networks.	0.4685
33821559	Addiction biology	2021	Circular RNA expression alteration identifies a novel circulating biomarker in serum exosomal for detection of alcohol dependence.	hsa_circ_0000896				Alcohol dependence 	MONDO:0007079	alcohol dependence	dysregulated	RT-qPCR; RNA-seq	hsa_circ_0000896 was identified as a top differentially expressed serum exosomal circRNA in AD and its differential expression was validated by qRT-PCR. The study links such circRNAs to potential miRNA-mediated mechanisms in AD.	0.4685
33821559	Addiction biology	2021	Circular RNA expression alteration identifies a novel circulating biomarker in serum exosomal for detection of alcohol dependence.	hsa_circ_0000825				Alcohol dependence 	MONDO:0007079	alcohol dependence	dysregulated	RT-qPCR; RNA-seq	hsa_circ_0000825 was selected among the top differentially expressed serum exosomal circRNAs in AD and showed significant qRT-PCR validation. Its potential disease relevance is framed through predicted circRNA-miRNA regulatory networks.	0.4685
33821559	Addiction biology	2021	Circular RNA expression alteration identifies a novel circulating biomarker in serum exosomal for detection of alcohol dependence.	hsa_circ_0007177				Alcohol dependence 	MONDO:0007079	alcohol dependence	dysregulated	RT-qPCR; RNA-seq	hsa_circ_0007177 was identified and qRT-PCR-validated as a significantly dysregulated serum exosomal circRNA in AD. The study places it within a broader set of circRNAs potentially involved in AD pathogenesis via miRNA interactions.	0.4685
33821559	Addiction biology	2021	Circular RNA expression alteration identifies a novel circulating biomarker in serum exosomal for detection of alcohol dependence.		hsa-circ_002910			Alcohol dependence 	MONDO:0007079	alcohol dependence	dysregulated	RT-qPCR; RNA-seq	hsa-circ_002910 was one of the top differentially expressed serum exosomal circRNAs selected from circRNA-seq and was significantly validated by qRT-PCR. The paper suggests that such circRNAs may contribute to AD-related molecular regulation through miRNA interactions.	0.4685
33821559	Addiction biology	2021	Circular RNA expression alteration identifies a novel circulating biomarker in serum exosomal for detection of alcohol dependence.		hsa-circ_004794			Alcohol dependence 	MONDO:0007079	alcohol dependence	dysregulated	RT-qPCR; RNA-seq	hsa-circ_004794 was selected as one of the top differentially expressed serum exosomal circRNAs in AD and showed significant qRT-PCR validation. It is implicated as part of a broader set of exosomal circRNAs that may be involved in AD pathogenesis through miRNA-related regulation.	0.4685
33822442	The journal of gene medicine	2021	hsa_circ_0001610 knockdown modulates miR-646-STAT3 axis to suppress endometrial carcinoma progression.	hsa_circ_0001610	circ_0001610	hsa_circ_TNFRSF21	TNFRSF21	Endometrial carcinoma 	MONDO:0002447	endometrial carcinoma	up-regulated	RT-qPCR	"hsa_circ_0001610/circ_0001610 is upregulated in endometrial carcinoma tissues and cell lines. Its knockdown suppresses EC progression by reducing proliferation, migration, invasion, glycolysis and xenograft tumor growth while increasing apoptosis, at least partly through the miR-646-STAT3 regulatory axis."	0.7184
33830389	Inflammation	2021	Circ_0114428 Regulates Sepsis-Induced Kidney Injury by Targeting the miR-495-3p/CRBN Axis.	hsa_circ_0114428	circ_0114428	hsa_circ_ZNF644	ZNF644	sepsis-induced kidney injury 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR	"circ_0114428 is up-regulated in serum from septic AKI patients and in LPS-induced HK2 cells. Functionally, circ_0114428 promotes LPS-induced kidney cell injury phenotypes, including apoptosis, inflammation, oxidative stress, and ER stress. Mechanistically, circ_0114428 acts through the miR-495-3p/CRBN axis and shows potential diagnostic value for septic AKI."	0.7932
33830472	Genes & genomics	2021	CircRNA_OTUD7A upregulates FOXP1 expression to facilitate the progression of diffuse large B-cell lymphoma via acting as a sponge of miR-431-5p.	hsa_circ_0034325	circ_OTUD7A 	hsa_circ_OTUD7A	OTUD7A	diffuse large B-cell lymphoma 	MONDO:0018905	diffuse large B-cell lymphoma	up-regulated	RT-qPCR	"circ_OTUD7A is up-regulated in DLBCL tissues and cell lines. It promotes DLBCL progression by enhancing proliferation, cell cycle progression, migration, invasion, metastasis and EMT while suppressing apoptosis, at least partly through sponging miR-431-5p to increase FOXP1 expression. The study suggests circ_OTUD7A may serve as a potential therapeutic target for DLBCL."	0.7799
33831787	Biochemical and biophysical research communications	2021	CircRNA circBACH1 (hsa_circ_0061395) serves as a miR-656-3p sponge to facilitate hepatocellular carcinoma progression through increasing SERBP1 expression.	hsa_circ_0061395	circBACH1	hsa_circ_BACH1	BACH1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circBACH1 (hsa_circ_0061395) is up-regulated in HCC tissues and cell lines. It promotes HCC cell proliferation, migration, invasion, EMT and xenograft tumor growth while suppressing apoptosis. Mechanistically, cytoplasmic circBACH1 functions as a ceRNA that sponges miR-656-3p/miR-656e3p to increase SERBP1 expression."	0.7635
33835399	Journal of molecular neuroscience : MN	2021	CircUBQLN1 Promotes Proliferation but Inhibits Apoptosis and Oxidative Stress of Hippocampal Neurons in Epilepsy via the miR-155-Mediated SOX7 Upregulation.	hsa_circ_0008038		hsa_circ_UBQLN1		epilepsy 	MONDO:0005027	epilepsy	down-regulated	RT-qPCR	"CircUBQLN1 is downregulated in TLE tissues and Mg2+-free-treated human hippocampal neurons. Its overexpression protects HN-h cells from epilepsy-like injury by promoting proliferation and reducing apoptosis and oxidative stress. Mechanistically, circUBQLN1 functions as a cytoplasmic miR-155 sponge to increase SOX7 expression, forming the circUBQLN1/miR-155/SOX7 regulatory axis."	0.7759
33837793	Experimental brain research	2021	"Circ_0132817 facilitates cell proliferation, migration, invasion and glycolysis by regulating the miR-432-5p/NOL4L axis in neuroblastoma."	hsa_circ_0132817	circ_0132817 	hsa_circ_CUX1	CUX1	Neuroblastoma 	MONDO:0005072	neuroblastoma	up-regulated	RT-qPCR	"circ_0132817 is up-regulated in neuroblastoma tissues and cell lines. It promotes NB proliferation, migration, invasion, glycolysis, cell cycle progression and xenograft tumor growth by sponging miR-432-5p and increasing NOL4L expression, suggesting a potential therapeutic relevance in NB."	0.7294
33843447	"Cell cycle (Georgetown, Tex.)"	2021	Circular RNA circ_HECTD1 regulates cell injury after cerebral infarction by miR-27a-3p/FSTL1 axis.		circ_HECTD1 	mmu_circ_HECTD1	HECTD1	cerebral infarction 	MONDO:0002679	cerebral infarction	up-regulated	RT-qPCR	"circ_HECTD1 is up-regulated in MCAO/R mouse brain tissues and OGD/R-treated HT22 cells. Its knockdown alleviates OGD/R-induced neural cell injury by promoting proliferation and suppressing apoptosis. Mechanistically, circ_HECTD1 acts as a ceRNA for miR-27a-3p to regulate FSTL1 expression, suggesting the circ_HECTD1/miR-27a-3p/FSTL1 axis as a potential therapeutic target in cerebral infarction."	0.6737
33844975	Experimental and molecular pathology	2021	"Circ-E2F3 acts as a ceRNA for miR-204-5p to promote proliferation, metastasis and apoptosis inhibition in retinoblastoma by regulating ROCK1 expression."	hsa_circ_0075804	circ-E2F3	hsa_circ_E2F3	E2F3	retinoblastoma 	MONDO:0008380	retinoblastoma	up-regulated	RT-qPCR	"Circ-E2F3 is upregulated in retinoblastoma tissues and cells and functions as a tumor-promoting circRNA. It promotes proliferation, migration, invasion, metastasis and xenograft tumor growth while inhibiting apoptosis, mainly through sponging miR-204-5p to increase ROCK1 expression."	0.7662
33855682	Inflammation	2021	Atractylon Treatment Attenuates Pulmonary Fibrosis via Regulation of the mmu_circ_0000981/miR-211-5p/TGFBR2 Axis in an Ovalbumin-Induced Asthma Mouse Model.	mmu_circ_0000981	circRNA-0000981			asthma-induced pulmonary fibrosis 	MONDO:0002771	pulmonary fibrosis	up-regulated	RT-qPCR	"mmu_circ_0000981/circRNA-0000981 is up-regulated in OVA-induced asthmatic pulmonary fibrosis and in TGF-beta1-treated TC-1 cells. It promotes EMT and fibrosis-associated protein expression through a ceRNA mechanism involving miR-211-5p and TGFBR2, while atractylon attenuates pulmonary fibrosis by suppressing this circRNA-mediated axis."	0.6369
33858292	"Cell cycle (Georgetown, Tex.)"	2021	NRF1-regulated CircNSUN2 promotes lymphoma progression through activating Wnt signaling pathway via stabilizing HMGA1.		circNSUN2	hsa_circ_NSUN2	NSUN2	malignant lymphoma 	MONDO:0005062	lymphoma	up-regulated	RT-qPCR	"circNSUN2 is up-regulated in malignant lymphoma tissues and lymphoma cell lines. It promotes lymphoma cell proliferation, migration and invasion, and its expression is regulated by the transcription factor NRF1. Mechanistically, circNSUN2 stabilizes HMGA1 by binding the HMGA1 3 UTR, thereby activating the Wnt/beta-catenin signaling pathway."	0.8324
33858297	Journal of receptor and signal transduction research	2022	circ-PSD3 promoted proliferation and invasion of papillary thyroid cancer cells via regulating the miR-7-5p/METTL7B axis.		circRNA pleckstrin and Sec7 domain containing 3	hsa_circ_PSD3	PSD3	papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circ-PSD3 is upregulated in human PTC tissues and cell lines and is associated with larger tumor size, advanced TNM stage, lymph node metastasis, and poor clinical prognosis. Functionally, circ-PSD3 promotes PTC cell proliferation and invasion by sponging miR-7-5p and increasing METTL7B expression, suggesting diagnostic, prognostic, and therapeutic potential."	0.6521
33862456	Biochemical and biophysical research communications	2021	Loss of androgen receptor promotes HCC invasion and metastasis via activating circ-LNPEP/miR-532-3p/RAB9A signal under hypoxia.	hsa_circ_0001513		hsa_circ_LNPEP	LNPEP	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ-LNPEP is an LNPEP-derived circRNA increased when AR is lost under hypoxia in HCC. It promotes HCC cell invasion and tumor metastasis by sponging miR-532e3p, thereby increasing RAB9A expression, and its overexpression reverses the suppressive effects of AR. The study also suggests circ-LNPEP may have diagnostic and therapeutic relevance in HCC."	0.7551
33862563	"Pathology, research and practice"	2021	Hsa_circ_0072309 inhibits proliferation and invasion of glioblastoma.	hsa_circ_0072309		hsa_circ_LIFR	LIFR	glioblastoma 	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR	"hsa_circ_0072309 is downregulated in GBM/glioma tissues compared with non-tumor brain tissues. Functionally, it suppresses GBM cell proliferation and invasion in vitro and reduces tumor growth in an intracranial U87 xenograft model. Mechanistically, the study links its tumor-suppressive effects to downregulation of HSP27 and changes in cytoskeleton/EMT-related markers."	0.622
33864191	Irish journal of medical science	2022	"Circular RNA_0000190 and its target microRNA-767-5p are dysregulated, and they are related to risk stratification as well as prognosis in multiple myeloma patients."	hsa_circ_0000190				multiple myeloma 	MONDO:0009693	plasma cell myeloma	down-regulated	RT-qPCR	"In this clinical study, circ_0000190 was significantly down-regulated in bone marrow plasma cells from multiple myeloma patients compared with healthy donors. Lower circ_0000190 was associated with worse risk-related clinical and biochemical features, while higher expression predicted better treatment response, better PFS and OS, and independently predicted better OS. circ_0000190 was negatively correlated with miR-767-5p, supporting a circRNA-miRNA association in MM prognosis."	0.5918
33864618	Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico	2021	Circ_03955 promotes pancreatic cancer tumorigenesis and Warburg effect by targeting the miR-3662/HIF-1alpha axis.		circ_03955			pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"circ_03955 is up-regulated in pancreatic cancer tissues and cell lines, and its high expression is associated with poor patient prognosis. Functionally, circ_03955 promotes PC cell growth, proliferation, xenograft tumorigenesis and Warburg-effect-related glycolysis while suppressing apoptosis. Mechanistically, it acts through the miR-3662/HIF-1alpha axis, functioning as a miR-3662 sponge to enhance HIF-1alpha expression."	0.7414
33865957	Genomics	2021	Trace the profile and function of circular RNAs in Sertoli cell only syndrome.		hsa_circRNA_101222			Sertoli cell-only syndrome 	MONDO:0005047	infertility disorder	down-regulated	RT-qPCR; Microarray	hsa_circRNA_101222 was identified by circRNA microarray and validated by qRT-PCR as down-regulated in SCOS testicular tissue relative to OA controls. The study did not experimentally define an individual mechanism for this circRNA.	0.4773
33865957	Genomics	2021	Trace the profile and function of circular RNAs in Sertoli cell only syndrome.		hsa_circRNA_001387			Sertoli cell-only syndrome 	MONDO:0005047	infertility disorder	down-regulated	RT-qPCR; Microarray	hsa_circRNA_001387 was identified by circRNA microarray and validated by qRT-PCR as down-regulated in SCOS testicular tissue relative to OA controls. The study did not experimentally define an individual mechanism for this circRNA.	0.4773
33865957	Genomics	2021	Trace the profile and function of circular RNAs in Sertoli cell only syndrome.		hsa_circRNA_103486 			Sertoli cell-only syndrome 	MONDO:0005047	infertility disorder	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_103486, also written as hsa_-circRNA_103486 in the article, was identified by microarray and validated by qRT-PCR as down-regulated in SCOS testicular tissue relative to OA controls. The study did not experimentally define an individual mechanism for this circRNA."	0.4773
33865957	Genomics	2021	Trace the profile and function of circular RNAs in Sertoli cell only syndrome.		hsa_circRNA_001153 			Sertoli cell-only syndrome 	MONDO:0005047	infertility disorder	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_001153, also written as hsa_-circRNA_001153 in the article, was identified by microarray and validated by qRT-PCR as up-regulated in SCOS testicular tissue relative to OA controls. The study did not experimentally define an individual mechanism for this circRNA."	0.4773
33865957	Genomics	2021	Trace the profile and function of circular RNAs in Sertoli cell only syndrome.		hsa_circRNA_101373 			Sertoli cell-only syndrome 	MONDO:0005047	infertility disorder	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_101373 was validated by qRT-PCR as up-regulated in SCOS and was described as the most significantly different circRNA between SCOS and control tissues. The authors predicted a ceRNA network in which hsa-circRNA-101373 interacts with five miRNAs and 109 target genes, implicating processes such as cell death, cell cycle arrest, spermatogenesis, stem cell maintenance, angiogenesis and immune-related signaling; however, this mechanism was bioinformatically predicted and not experimentally proven."	0.5135
33865957	Genomics	2021	Trace the profile and function of circular RNAs in Sertoli cell only syndrome.		hsa_circRNA_103864			Sertoli cell-only syndrome 	MONDO:0005047	infertility disorder	up-regulated	RT-qPCR; Microarray	hsa_circRNA_103864 was identified by circRNA microarray and validated by qRT-PCR as up-regulated in SCOS testicular tissue relative to OA controls. The study did not experimentally define an individual mechanism for this circRNA.	0.4773
33884524	Lasers in medical science	2022	LLLI promotes BMSC proliferation through circRNA_0001052/miR-124-3p.	mmu_circ_0001052	circRNA_0001052 			Osteoporosis 	MONDO:0005298	osteoporosis	down-regulated	RT-qPCR	"This study investigated circRNA_0001052 in mouse BMSCs in the context of LLLI as a potential OP-related therapeutic approach. LLLI downregulated circRNA_0001052, and loss of circRNA_0001052 promoted BMSC proliferation by releasing miR-124-3p and upregulating the Wnt4/beta-catenin pathway. The evidence supports circRNA_0001052 as a negative regulator of BMSC proliferation."	0.6812
33887546	"Pathology, research and practice"	2021	CircRNA circTRAF3 promotes nasopharyngeal carcinoma metastasis through targeting miR-203a-3p/AKT3 axis.		circTRAF3 	hsa_circ_TRAF3	TRAF3	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circTRAF3 is up-regulated in NPC, especially metastatic NPC, and high expression is associated with poor survival. It promotes NPC growth, proliferation, invasion and metastasis while suppressing apoptosis by sponging miR-203a-3p to up-regulate AKT3 and activate AKT/EMT-related oncogenic signaling."	0.8308
33887546	"Pathology, research and practice"	2021	CircRNA circTRAF3 promotes nasopharyngeal carcinoma metastasis through targeting miR-203a-3p/AKT3 axis.		circTTC39C	hsa_circ_TTC39C		nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; Microarray	circTTC39C was identified during screening of circRNAs in NPC and validated by qPCR as increased in NPC tissues. No functional mechanism or clinical prognostic role was further characterized for this circRNA in the article.	0.3588
33887546	"Pathology, research and practice"	2021	CircRNA circTRAF3 promotes nasopharyngeal carcinoma metastasis through targeting miR-203a-3p/AKT3 axis.		circSHMT1	hsa_circ_SHMT1		nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; Microarray	circSHMT1 was identified during screening of circRNAs in NPC and validated by qPCR as increased in NPC tissues. No functional mechanism or clinical prognostic role was further characterized for this circRNA in the article.	0.3588
33887546	"Pathology, research and practice"	2021	CircRNA circTRAF3 promotes nasopharyngeal carcinoma metastasis through targeting miR-203a-3p/AKT3 axis.		circSENP5	hsa_circ_SENP5		nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; Microarray	circSENP5 was identified during screening of circRNAs in NPC and validated by qPCR as increased in NPC tissues. No functional mechanism or clinical prognostic role was further characterized for this circRNA in the article.	0.3588
33887546	"Pathology, research and practice"	2021	CircRNA circTRAF3 promotes nasopharyngeal carcinoma metastasis through targeting miR-203a-3p/AKT3 axis.		circZNF512	hsa_circ_ZNF512		nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	down-regulated	RT-qPCR; Microarray	circZNF512 was identified during screening of circRNAs in NPC and validated by qPCR as decreased in in situ and metastatic NPC. No functional mechanism or clinical prognostic role was further characterized for this circRNA in the article.	0.3588
33892093	Cellular signalling	2021	CircZNF208 enhances the sensitivity to X-rays instead of carbon-ions through the miR-7-5p /SNCA signal axis in non-small-cell lung cancer cells.	hsa_circ_0109301	circRNA ZNF208 	hsa_circ_ZNF208	ZNF208	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"In NSCLC radioresistant A549-R11 cells, circZNF208 is upregulated and promotes resistance to low-LET X-ray irradiation. It functions as a ceRNA sponge for miR-7-5p, leading to increased SNCA expression and activation of the JAK2-STAT3-related pathway. circZNF208 knockdown sensitizes NSCLC cells to X-rays but not to carbon-ion irradiation, suggesting potential value as a biomarker for radiotherapy modality selection."	0.8161
33895481	International immunopharmacology	2021	Knockdown of circ-UQCRC2 ameliorated lipopolysaccharide-induced injury in MRC-5 cells by the miR-326/PDCD4/NF-kappaB pathway.	hsa_circ_0038467	circRNA ubiquinol-cytochrome c reductase core protein 2 	hsa_circ_UQCRC2	UQCRC2	pediatric pneumonia 	MONDO:0005249	pneumonia	up-regulated	RT-qPCR	"circ-UQCRC2 is up-regulated in pediatric pneumonia serum and LPS-treated human MRC-5 lung fibroblastic cells. Functionally, circ-UQCRC2 promotes LPS-induced inflammatory injury, apoptosis, and NF-kappaB activation, while its knockdown alleviates cell injury. Mechanistically, circ-UQCRC2 directly targets miR-326 to regulate PDCD4 and the NF-kappaB pathway, and its expression correlates with clinical severity features in pediatric pneumonia."	0.7581
33896835	Cancer biomarkers : section A of Disease markers	2021	Silencing circPVT1 enhances radiosensitivity in non-small cell lung cancer by sponging microRNA-1208.		CircRNA plasmacytoma variant translocation 1 (PVT1) 	hsa_circ_PVT1	PVT1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circPVT1 is up-regulated in NSCLC cell lines and further induced by irradiation. Its silencing enhances radiosensitivity, inhibits proliferation and invasion, promotes apoptosis, and blocks PI3K/AKT/mTOR signaling through up-regulation of miR-1208, supporting circPVT1 as a potential radiosensitivity-related therapeutic target in NSCLC."	0.627
33896837	Cancer biomarkers : section A of Disease markers	2021	Downregulated hsa_circ_0036988 promotes proliferation and metastasis in oral squamous cell carcinoma.	hsa_circ_0036988	hsa_circRNA_0036988	hsa_circ_CHD2	CHD2	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR; RNA-seq	"This study identifies hsa_circ_0036988 as a down-regulated circRNA in OSCC tissues and cell lines. Functional experiments indicate that hsa_circ_0036988 acts as a tumor suppressor by inhibiting proliferation, migration, invasion and EMT-related changes, while low expression correlates with lymph node metastasis and has potential diagnostic value."	0.6758
33908023	Human cell	2021	Circ_0067835 regulates allergic inflammatory response in type-2 innate lymphoid cells in allergic rhinitis (AR) via miR-155/GATA3.	mmu_circ_0067835	circ_0067835			Allergic rhinitis 	MONDO:0011786	allergic rhinitis	up-regulated	RT-qPCR	"circ_0067835 is up-regulated in nasal mucosa tissues of IL-33-induced AR mice. Its knockdown alleviates allergic symptoms, Type2 cytokine production, and ILC2 accumulation, likely through down-regulating the miR-155/GATA3 axis."	0.6867
33915163	Brain research	2021	CircRNA SEPT9 contributes to malignant behaviors of glioma cells via miR-432-5p-mediated regulation of LASP1.	hsa_circ_0005320	Circular RNA (circRNA) septin 9 	hsa_circ_SEPT9	SEPT9	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"CircSEPT9 (hsa_circ_0005320) is up-regulated in glioma tissues and cell lines. It functions as an oncogenic circRNA by sponging miR-432-5p and thereby increasing LASP1 expression, promoting proliferation, migration, invasion, glycolysis, cell cycle progression, and xenograft tumor growth while inhibiting apoptosis."	0.7795
33934291	Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico	2021	Circular RNA hsa_circ_0091579 facilitates the Warburg effect and malignancy of hepatocellular carcinoma cells via the miR-624/H3F3B axis.	hsa_circ_0091579	circ_0091579	hsa_circ_GPC3	GPC3	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"hsa_circ_0091579/circ_0091579 is upregulated in HCC tissues and cells and acts as an oncogenic circRNA. Mechanistically, it sponges miR-624 to increase H3F3B expression, thereby promoting the Warburg effect, migration, invasion, malignant behavior, and xenograft tumor growth while suppressing apoptosis."	0.7295
33945396	"Cell cycle (Georgetown, Tex.)"	2021	Knockdown of hsa_circ_0134111 alleviates the symptom of osteoarthritis via sponging microRNA-224-5p.	hsa_circ_0134111	circ_PDE1C 	hsa_circ_PDE1C	PDE1C	osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0134111/circ_PDE1C is up-regulated in osteoarthritis cartilage and positively associated with Mankin score. It promotes chondrocyte apoptosis, ECM degradation, and cartilage degeneration by sponging miR-224-5p, thereby increasing CCL2 and activating JAK/STAT3 signaling. Knockdown of circ_PDE1C alleviates OA-related cellular phenotypes, suggesting therapeutic potential."	0.7421
33945401	"Cell cycle (Georgetown, Tex.)"	2021	Circ_0017956 promotes the proliferation and metastasis of non-small cell lung cancer through regulating miR-515-5p/ITGB8 axis.	hsa_circ_0017956	circ_0017956	hsa_circ_MLLT10	MLLT10	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0017956 is up-regulated in NSCLC tissues and cell lines and is associated with lymph node metastasis and advanced TNM stage. Functionally, circ_0017956 promotes NSCLC proliferation, migration, invasion, metastasis and xenograft tumor growth. Mechanistically, it mainly localizes to the cytoplasm and acts as a ceRNA that sponges miR-515-5p to increase ITGB8 expression."	0.7519
33945806	Experimental and molecular pathology	2021	Circ_ZFP644 attenuates caerulein-induced inflammatory injury in rat pancreatic acinar cells by modulating miR-106b/Pias3 axis.		circular RNA zinc finger protein 644 	rno_circ_ZFP644	ZFP644	acute pancreatitis 	MONDO:0006515	acute pancreatitis	down-regulated	RT-qPCR	"circ_ZFP644 is down-regulated in a caerulein-induced rat AR42J acute pancreatitis cell model. Its overexpression suppresses amylase activation and inflammatory cytokine secretion while promoting apoptosis. Mechanistically, circ_ZFP644 sponges miR-106b to increase Pias3 expression, thereby attenuating inflammatory injury."	0.6376
33961985	Toxicology letters	2021	CircRNA_0026344 via exosomal miR-21 regulation of Smad7 is involved in aberrant cross-talk of epithelium-fibroblasts during cigarette smoke-induced pulmonary fibrosis.	hsa_circ_0026344	circRNA_0026344			cigarette smoke-induced pulmonary fibrosis 	MONDO:0005275	lung disorder	down-regulated	RT-qPCR; Microarray	"circRNA_0026344 is down-regulated in cigarette smoke/CSE-exposed bronchial epithelial cells. Its reduction increases miR-21 availability, enabling exosomal miR-21 transfer to bronchial fibroblasts, where miR-21 suppresses Smad7 and activates TGF-beta1/Smads signaling. This promotes fibroblast differentiation, ECM deposition, and smoking-induced pulmonary fibrosis, suggesting circRNA_0026344 as a potential biomarker or therapeutic target."	0.642
33965787	Biochemical and biophysical research communications	2021	Gastric cancer derived exosomes mediate the delivery of circRNA to promote angiogenesis by targeting miR-29a/VEGF axis in endothelial cells.	hsa_circ_0044366	circ_0044366 	hsa_circ_ATP5G1	ATP5G1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"Exosomal circ29 is up-regulated in GC plasma and GC cells and is mainly carried in plasma exosomes. It promotes endothelial proliferation, migration/invasion, tube formation, angiogenesis and tumor growth by sponging miR-29a and increasing VEGF signaling/expression. The study suggests circ29 may be a therapeutic target and potential clinical marker for GC."	0.7369
33969901	Hematological oncology	2021	"Circ_0009910 shuttled by exosomes regulates proliferation, cell cycle and apoptosis of acute myeloid leukemia cells by regulating miR-5195-3p/GRB10 axis."	hsa_circ_0009910	circ_0009910 	hsa_circ_MFN2	MFN2	acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"In AML, hsa_circ_0009910/circ_0009910 is up-regulated in bone marrow samples, AML cell lines, and AML cell-derived exosomes. It functions as an oncogenic exosomal circRNA that promotes proliferation and cell cycle progression while inhibiting apoptosis, at least partly through the circ_0009910/miR-5195-3p/GRB10 ceRNA axis. Clinically, higher circ_0009910 expression is associated with AML risk status and poor-risk disease."	0.7032
33971492	International immunopharmacology	2021	CircATRNL1 protects against osteoarthritis by targeting miR-153-3p and KLF5.		circATRNL1 	hsa_circ_ATRNL1	ATRNL1	osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR; Microarray	"CircATRNL1 is down-regulated in OA cartilage and IL-1beta-treated human chondrocytes. Its overexpression protects chondrocytes by reducing apoptosis, inflammatory responses, and ECM degradation, likely through regulation of the miR-153-3p/KLF5 axis. The study suggests circATRNL1 as a potential therapeutic target for OA."	0.7291
33975327	Nephron	2021	Hsa Circ 001839 Promoted Inflammation in Renal Ischemia-Reperfusion Injury Through NLRP3 by miR-432-3p.		hsa Circ 001839 			renal ischemia-reperfusion injury 	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR; Microarray	"circ 001839 is up-regulated in renal ischemia-reperfusion injury rats and NRK52E in vitro injury models. The study indicates that circ 001839 promotes inflammation by suppressing miR-432-3p and inducing NLRP3/caspase-1-associated inflammatory cytokine production, suggesting circ 001839 as a potential therapeutic target for RI-RI."	0.5997
33978716	Acta biochimica et biophysica Sinica	2021	"hsa_circ_0062019 promotes the proliferation, migration, and invasion of prostate cancer cells via the miR-195-5p/HMGA2 axis."	hsa_circ_0062019				prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"hsa_circ_0062019 is up-regulated in prostate cancer cell lines and promotes proliferation, migration, and invasion. Mechanistically, it sponges miR-195-5p to increase HMGA2 expression, and HMGA2 knockdown reverses the hsa_circ_0062019-induced malignant phenotypes."	0.5554
33978765	Inflammation research : official journal of the European Histamine Research Society ... [et al.]	2021	Silencing circANKRD36 inhibits streptozotocin-induced insulin resistance and inflammation in diabetic rats by targeting miR-145 via XBP1.		circANKRD36 	rno_circ_ANKRD36	ANKRD36	Diabetes mellitus 	MONDO:0005015	diabetes mellitus	up-regulated	RT-qPCR	"circANKRD36 is up-regulated in STZ-induced T2DM rats. Its silencing ameliorates insulin resistance, lowers blood glucose and insulin, increases adiponectin, and reduces pancreatic inflammation and apoptosis. Mechanistically, circANKRD36 acts through a miR-145/XBP1-related axis, with circANKRD36 knockdown increasing miR-145 and suppressing XBP1/CHOP-associated ER stress markers."	0.5627
33979737	Biochemical and biophysical research communications	2021	Knockdown of circBFAR inhibits proliferation and glycolysis in gastric cancer by sponging miR-513a-3p/hexokinase 2 axis.	hsa_circ_0009065	circBFAR	hsa_circ_BFAR	BFAR	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circBFAR is up-regulated in gastric cancer tissues and cell lines. It promotes GC proliferation, tumor growth and glycolysis by sponging miR-513a-3p and up-regulating HK2, suggesting a potential therapeutic target for individualized GC treatment."	0.7581
33988065	Current eye research	2021	CircMKLN1 Suppresses the Progression of Human Retinoblastoma by Modulation of miR-425-5p/PDCD4 Axis.		circRNA muskelin 1 	hsa_circ_MKLN1	MKLN1	retinoblastoma 	MONDO:0008380	retinoblastoma	down-regulated	RT-qPCR	"CircMKLN1 is down-regulated in retinoblastoma tissues and cells, and higher circMKLN1 expression is associated with better overall survival. Functionally, circMKLN1 suppresses RB cell proliferation, migration, invasion, EMT-related protein changes, and xenograft tumor growth. Mechanistically, circMKLN1 acts through the circMKLN1/miR-425-5p/PDCD4 axis by sponging miR-425-5p and increasing PDCD4 expression."	0.8439
33992597	Archives of biochemistry and biophysics	2021	Use Chou's 5-steps rule to study how Baicalin suppresses the malignant phenotypes and induces the apoptosis of colorectal cancer cells.	hsa_circ_0092283	circRNA myosin heavy chain 9	hsa_circ_MYH9	MYH9	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circMYH9 is up-regulated in colorectal cancer tissues and cell lines and is reduced by Baicalin treatment. Functionally, circMYH9 promotes malignant phenotypes and attenuates Baicalin-induced anti-tumor effects by sponging miR-761 and up-regulating HDGF in CRC cells."	0.795
33993369	Cellular and molecular neurobiology	2022	Circ-EGFR Functions as an Inhibitory Factor in the Malignant Progression of Glioma by Regulating the miR-183-5p/TUSC2 Axis.	hsa_circ_0080223	circRNA epidermal growth factor receptor 	hsa_circ_EGFR	EGFR	glioma	MONDO:0021042	glioma	down-regulated	RT-qPCR	"Circ-EGFR is down-regulated in glioma tissues and glioma cell lines. Functional assays show that circ-EGFR overexpression suppresses proliferation, migration, invasion and tumor growth while promoting apoptosis. Mechanistically, circ-EGFR acts as a miR-183-5p sponge to increase TUSC2 expression, forming a tumor-inhibitory circ-EGFR/miR-183-5p/TUSC2 axis."	0.6542
34008433	Autoimmunity	2021	Circular RNAs hsa-circ0000175 and hsa-circ0044235 in plasma are novel biomarkers for new-onset rheumatoid arthritis.	hsa_circ_0000175				rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"In this clinical biomarker study, plasma hsa-circ0000175 was significantly up-regulated in new-onset RA patients compared with healthy controls. Its plasma expression correlated with platelet-related clinical variables and showed diagnostic value for distinguishing RA from control groups, especially when combined with hsa-circ0044235."	0.5261
34008433	Autoimmunity	2021	Circular RNAs hsa-circ0000175 and hsa-circ0044235 in plasma are novel biomarkers for new-onset rheumatoid arthritis.	hsa_circ_0044235				rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	down-regulated	RT-qPCR	"In this clinical biomarker study, plasma hsa-circ0044235 was significantly down-regulated in new-onset RA patients compared with healthy controls. Its expression correlated negatively with disease activity and severity indicators such as DAS-ESR, DAS-CRP, PJC, and SJC, and it contributed to diagnostic discrimination of RA, particularly in combination with hsa-circ0000175."	0.5261
34011217	Current eye research	2021	CircPAG1 Inhibits the High Glucose-Induced Lens Epithelial Cell Injury by Sponging miR-630 and Upregulating EPHA2.	hsa_circ_0006057	circPAG1 	hsa_circ_PAG1	PAG1	diabetic cataract 	MONDO:0001687	diabetic cataract	down-regulated	RT-qPCR	"CircPAG1 is downregulated in diabetic cataract lens samples and high glucose-treated human lens epithelial cells. Functionally, circPAG1 overexpression protects lens epithelial cells from high glucose-induced injury by promoting proliferation and suppressing apoptosis and oxidative stress. Mechanistically, circPAG1 sponges miR-630 to upregulate EPHA2, suggesting a circPAG1/miR-630/EPHA2 regulatory axis and potential therapeutic relevance in diabetic cataract."	0.7968
34017077	Oncogene	2021	FMR1/circCHAF1A/miR-211-5p/HOXC8 feedback loop regulates proliferation and tumorigenesis via MDM2-dependent p53 signaling in GSCs.	hsa_circ_0000876	circRNA-CHAF1A 	hsa_circ_CHAF1A	CHAF1A	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR; Microarray	"CircCHAF1A is a CHAF1A-derived human circRNA overexpressed in glioma, especially TP53-wildtype gliomas, and high expression is associated with poorer survival. It promotes TP53wt glioma stem cell proliferation, cell-cycle progression, self-renewal, and intracranial tumorigenesis by sponging miR-211-5p to increase HOXC8, which upregulates MDM2 and suppresses p53 signaling. FMR1 stabilizes circCHAF1A, and HOXC8 transcriptionally induces FMR1, forming a positive FMR1/circCHAF1A/miR-211-5p/HOXC8 feedback loop with biomarker and therapeutic relevance."	0.88
34018092	Cell biology and toxicology	2022	CircRNA VIM silence synergizes with sevoflurane to inhibit immune escape and multiple oncogenic activities of esophageal cancer by simultaneously regulating miR-124/PD-L1 axis.		circ-VIM 	hsa_circ_VIM	vimentin	esophageal cancer 	MONDO:0007576	esophageal cancer	up-regulated	RT-qPCR	"circ-VIM is up-regulated in esophageal cancer tissues and cell lines, and higher expression is associated with advanced TNM stage and lymph node metastasis. Functionally, circ-VIM promotes EC proliferation, migration, invasion, EMT, metastasis, xenograft growth, and immune escape by sponging miR-124 and derepressing PD-L1, with downstream Ras/ERK signaling involvement. Silencing circ-VIM synergizes with sevoflurane to suppress malignant phenotypes and enhance CD8 + T-cell antitumor activity through the miR-124/PD-L1 axis."	0.7554
34018640	Journal of clinical laboratory analysis	2021	"Dysregulated circ_0004913, circ_0008160, circ_0000517, and their potential as biomarkers for disease monitoring and prognosis in hepatocellular carcinoma."	hsa_circ_0004913	Circular RNA_0004913 			hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"This study found that circ_0004913 is downregulated in HCC tumor tissue compared with paired adjacent tissue. Higher tumor circ_0004913 expression was associated with smaller tumor burden, earlier BCLC stage, and longer overall survival, suggesting clinical biomarker potential rather than a mechanistically tested role in this paper."	0.5918
34018640	Journal of clinical laboratory analysis	2021	"Dysregulated circ_0004913, circ_0008160, circ_0000517, and their potential as biomarkers for disease monitoring and prognosis in hepatocellular carcinoma."	hsa_circ_0008160	circular RNA_0008160 			hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"This study found that circ_0008160 is downregulated in HCC tumor tissue compared with paired adjacent tissue. It was not associated with clinicopathological characteristics overall, but the abstract reports that high tumor circ_0008160 expression correlated with longer OS in the BCLC stage B subgroup."	0.5918
34018640	Journal of clinical laboratory analysis	2021	"Dysregulated circ_0004913, circ_0008160, circ_0000517, and their potential as biomarkers for disease monitoring and prognosis in hepatocellular carcinoma."	hsa_circ_0000517	circular RNA_0000517 			hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"This study found that circ_0000517 is upregulated in HCC tumor tissue compared with paired adjacent tissue. Unlike circ_0004913, circ_0000517 was not associated with clinicopathological characteristics or OS in the reported analyses, although it contributed to a combined three-circRNA tissue-discrimination ROC model."	0.5918
34021822	Digestive diseases and sciences	2022	"Circ_0001955 Acts as a miR-646 Sponge to Promote the Proliferation, Metastasis and Angiogenesis of Hepatocellular Carcinoma."	hsa_circ_0001955	circ_0001955	hsa_circ_CSNK1G1	CSNK1G1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0001955 is up-regulated in HCC tissues and cell lines and is associated with tumor size, AFP level, and increasing malignancy. Functionally, circ_0001955 promotes proliferation, cell-cycle progression, migration, invasion, angiogenesis, and in vivo tumor growth while inhibiting apoptosis. Mechanistically, it acts as a ceRNA for miR-646 to increase FZD4 expression, forming a circ_0001955/miR-646/FZD4 axis that supports HCC progression."	0.8299
34022068	European journal of clinical investigation	2021	Exosomal circEPB41L2 serves as a sponge for miR-21-5p and miR-942-5p to suppress colorectal cancer progression by regulating the PTEN/AKT signalling pathway.	hsa_circ_0001640	circEPB41L2	hsa_circ_EPB41L2	EPB41L2	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"Exosomal circEPB41L2 is downregulated in plasma exosomes from colorectal cancer patients and in colorectal cancer cells. It functions as a tumour suppressor by sponging miR-21-5p and miR-942-5p, increasing PTEN and inhibiting AKT activation, thereby reducing proliferation, migration, invasion and tumour growth while promoting apoptosis. It also showed potential diagnostic value for colorectal cancer and tumour staging."	0.8325
34023283	Archives of biochemistry and biophysics	2021	"CircSOS2 promotes cervical squamous cell carcinoma by regulation of proliferation, cell cycle, apoptosis, migration, invasion, and glycolysis by targeting miR-543/FNDC3B axis."	hsa_circ_0101996	circular RNA salt overly-sensitive 2	hsa_circ_SOS2	SOS2	cervical squamous cell carcinoma 	MONDO:0006143	cervical squamous cell carcinoma	up-regulated	RT-qPCR	"CircSOS2 is up-regulated in human cervical squamous cell carcinoma tissues and cells and high expression predicts poor overall survival. Functionally, circSOS2 promotes SCC cell proliferation, cell cycle progression, migration, invasion, glycolysis, and in vivo tumor growth while suppressing apoptosis. Mechanistically, it acts through the miR-543/FNDC3B axis."	0.8689
34024023	Digestive diseases and sciences	2022	Circular RNA circ_0006948 Promotes Esophageal Squamous Cell Carcinoma Progression by Regulating microRNA-3612/LASP1 Axis.	hsa_circ_0006948	circ_0006948	hsa_circ_FNDC3B	FNDC3B	Esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"circ_0006948 is up-regulated in ESCC tissues and cells, and high expression is associated with shorter overall survival. Functionally, circ_0006948 promotes ESCC proliferation, migration, invasion, glycolysis and in vivo tumor growth while inhibiting apoptosis. Mechanistically, it acts as a cytoplasmic ceRNA by sponging miR-3612 to increase LASP1 expression."	0.8174
34024202	Vascular	2022	Microarray profile of circular RNAs identifies hsa_circ_000455 as a new circular RNA biomarker for deep vein thrombosis.		hsa_circ_000455 			deep vein thrombosis 	MONDO:0000831	thrombotic disease	up-regulated	RT-qPCR; Microarray	hsa_circ_000455 was significantly up-regulated in blood samples from DVT patients and validated by qRT-PCR. The study proposes that it may act as a biomarker and may promote DVT through the predicted hsa_circRNA_000455/hsa-miR-22-3p/NLRP3 ceRNA axis.	0.5135
34024202	Vascular	2022	Microarray profile of circular RNAs identifies hsa_circ_000455 as a new circular RNA biomarker for deep vein thrombosis.		hsa_circ_101515 			deep vein thrombosis 	MONDO:0000831	thrombotic disease	up-regulated	RT-qPCR; Microarray	hsa_circ_101515 was significantly up-regulated in DVT patient blood samples and validated by qRT-PCR. The study reported predicted miRNA response element interactions but did not experimentally define its mechanism or function.	0.5135
34024202	Vascular	2022	Microarray profile of circular RNAs identifies hsa_circ_000455 as a new circular RNA biomarker for deep vein thrombosis.		hsa_circ_101212 			deep vein thrombosis 	MONDO:0000831	thrombotic disease	up-regulated	RT-qPCR; Microarray	hsa_circ_101212 was significantly up-regulated in DVT patient blood samples and validated by qRT-PCR. The study reported predicted miRNA interactions but did not experimentally test its specific function.	0.5135
34024202	Vascular	2022	Microarray profile of circular RNAs identifies hsa_circ_000455 as a new circular RNA biomarker for deep vein thrombosis.		hsa_circ_000185 			deep vein thrombosis 	MONDO:0000831	thrombotic disease	down-regulated	RT-qPCR; Microarray	"hsa_circ_000185 was significantly down-regulated in DVT patient blood samples and validated by qRT-PCR. Its predicted miRNA interactions were reported, but its functional role in DVT was not experimentally characterized."	0.5135
34024202	Vascular	2022	Microarray profile of circular RNAs identifies hsa_circ_000455 as a new circular RNA biomarker for deep vein thrombosis.		hsa_circ_001982 			deep vein thrombosis 	MONDO:0000831	thrombotic disease	down-regulated	RT-qPCR; Microarray	hsa_circ_001982 was significantly down-regulated in DVT patient blood samples and validated by qRT-PCR. The article reported predicted miRNA interactions for this circRNA but did not experimentally define a functional mechanism.	0.5135
34024251	"Cell cycle (Georgetown, Tex.)"	2021	Blocking hsa_circ_0006168 suppresses cell proliferation and motility of human glioblastoma cells by regulating hsa_circ_0006168/miR-628-5p/IGF1R ceRNA axis.	hsa_circ_0006168	hsa_circRNA_103670	hsa_circ_CNOT6L	CNOT6L	glioblastoma 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0006168 is up-regulated in human GBM tissues and cell lines. It promotes GBM proliferation, migration, invasion, colony formation, EMT and xenograft tumor growth, while inhibiting apoptosis. Mechanistically, hsa_circ_0006168 sponges miR-628-5p to regulate IGF1R and activate the Ras/Erk signaling pathway."	0.7595
34028600	Inflammation research : official journal of the European Histamine Research Society ... [et al.]	2021	Targeting a novel hsa_circ_0000520/miR-556-5p/NLRP3 pathway-mediated cell pyroptosis and inflammation attenuates ovalbumin (OVA)-induced allergic rhinitis (AR) in mice models.	hsa_circ_0000520				allergic rhinitis 	MONDO:0011786	allergic rhinitis	up-regulated	RT-qPCR	"hsa_circ_0000520 is up-regulated in allergic rhinitis samples and OVA-induced AR models. It acts as a ceRNA for miR-556-5p to regulate NLRP3, thereby promoting epithelial pyroptosis and inflammation; knockdown of hsa_circ_0000520 attenuates AR phenotypes in vitro and in vivo."	0.7164
34029698	Genomics	2021	Profiling of circular RNAs and circTPCN/miR-634/mTOR regulatory pathway in cervical cancer.			hsa_circ_TPCN	TPCN	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"circTPCN is significantly up-regulated in cervical cancer samples and may serve as a biomarker. Functionally, circTPCN promotes cervical cancer cell proliferation, migration and invasion while suppressing apoptosis. Mechanistically, it acts mainly as a miR-634 sponge to enhance mTOR expression, forming a circTPCN/miR-634/mTOR regulatory pathway."	0.6777
34029698	Genomics	2021	Profiling of circular RNAs and circTPCN/miR-634/mTOR regulatory pathway in cervical cancer.			hsa_circ_FAM185A	FAM185A	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"circFAM185A is significantly up-regulated in cervical cancer samples and was proposed as a potential biomarker for cervical cancer. Functional testing showed that circFAM185A knockdown suppressed proliferation in C33A cells, although it did not affect Hela cell proliferation. No specific molecular mechanism or regulatory axis was established for circFAM185A in this study."	0.4625
34032284	European journal of clinical investigation	2021	Circ_0027599 elevates RUNX1 expression via sponging miR-21-5p on gastric cancer progression.	hsa_circ_0027599				gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"Circ_0027599 is down-regulated in gastric cancer tissues and cells, and higher expression is associated with better overall survival. Functionally, circ_0027599 suppresses GC cell viability, colony formation, migration, invasion, cell cycle progression and xenograft tumour growth. Mechanistically, it sponges miR-21-5p to elevate RUNX1 expression, forming a circ_0027599/miR-21-5p/RUNX1 regulatory axis."	0.7794
34036483	Journal of bioenergetics and biomembranes	2021	Circ_RPL23A acts as a miR-1233 sponge to suppress the progression of clear cell renal cell carcinoma by promoting ACAT2.	hsa_circ_0092360	circRNA ribosomal protein L23a 	hsa_circ_RPL23A	RPL23A	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	down-regulated	RT-qPCR; Microarray	"circ_RPL23A/hsa_circ_0092360 is down-regulated in clear cell renal cell carcinoma tissues and cells and functions as a tumor suppressor. It inhibits ccRCC progression by sponging miR-1233, thereby increasing ACAT2 expression, which suppresses proliferation, cell cycle progression, migration, invasion and EMT while promoting apoptosis and reducing xenograft tumor growth."	0.8122
34036857	Autoimmunity	2021	Dysregulation of tumour microenvironment driven by circ-TPGS2/miR-7/TRAF6/NF-kappaB axis facilitates breast cancer cell motility.		circ-TPGS2 	hsa_circ_TPGS2	TPGS2	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circ-TPGS2 is up-regulated in metastatic breast cancer tissues and high-metastatic breast cancer cell lines and predicts poorer overall and recurrence-free survival. Functionally, it promotes breast cancer migration, dissemination and lung metastasis while remodeling the tumor microenvironment by inducing pro-inflammatory chemokines and neutrophil recruitment. Mechanistically, circ-TPGS2 sponges miR-7 to increase TRAF6 and activate NF-kappaB signaling, while p65 transcriptionally activates circ-TPGS2 to form a positive feedback loop."	0.8757
34037956	"Reproductive sciences (Thousand Oaks, Calif.)"	2021	Circ_0019435 Exerts Its Functions in the Cellular Process of Cervical Cancer via Epigenetically Silencing DKK1 and PTEN.	hsa_circ_0019435	circ_0019435	hsa_circ_ABCC2	ABCC2	Cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ_0019435 is up-regulated in cervical cancer cell lines and functions as an oncogenic circRNA. It mainly localizes to the nucleus, binds EZH2, and epigenetically represses DKK1 and PTEN, thereby activating Wnt/beta-catenin and PI3K/Akt signaling to promote proliferation, invasion, and EMT while inhibiting apoptosis."	0.809
34041646	Inflammation	2021	CircANKRD36 Knockdown Suppressed Cell Viability and Migration of LPS-Stimulated RAW264.7 Cells by Sponging MiR-330.		circANKRD36 	hsa_circ_ANKRD36	ANKRD36	Acute lung injury 	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR; Microarray	"circANKRD36 is up-regulated in serum from patients with sepsis-induced ARDS and in LPS-stimulated RAW264.7 cells. Functionally, circANKRD36 promotes cell viability, migration and inflammatory cytokine expression, while knockdown suppresses these phenotypes. Mechanistically, circANKRD36 acts as a sponge for miR-330 to regulate ROCK1 expression, suggesting a circANKRD36/miR-330/ROCK1 regulatory axis in sepsis-induced ARDS."	0.7372
34041646	Inflammation	2021	CircANKRD36 Knockdown Suppressed Cell Viability and Migration of LPS-Stimulated RAW264.7 Cells by Sponging MiR-330.		circANKRD36 	mmu_circ_ANKRD36	ANKRD36	Acute lung injury 	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR; Microarray	"circANKRD36 is up-regulated in serum from patients with sepsis-induced ARDS and in LPS-stimulated RAW264.7 cells. Functionally, circANKRD36 promotes cell viability, migration and inflammatory cytokine expression, while knockdown suppresses these phenotypes. Mechanistically, circANKRD36 acts as a sponge for miR-330 to regulate ROCK1 expression, suggesting a circANKRD36/miR-330/ROCK1 regulatory axis in sepsis-induced ARDS."	0.7372
34046939	Drug development research	2021	CircMYBL2 regulates the resistance of cervical cancer cells to paclitaxel via miR-665-dependent regulation of EGFR.	hsa_circ_0060467	CircMYBL2	hsa_circ_MYBL2	MYBL2	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"CircMYBL2 is upregulated in cervical cancer, with higher expression in PTX-resistant tissues and cells. It promotes paclitaxel resistance, tumor growth, and malignant cellular behaviors by sponging miR-665 and thereby increasing EGFR expression, suggesting potential value as a biomarker and therapeutic target for PTX-resistant cervical cancer."	0.7859
34050452	Biochemical genetics	2021	CircARL8B Contributes to the Development of Breast Cancer Via Regulating miR-653-5p/HMGA2 Axis.	hsa_circ_0005046	circARL8B 	hsa_circ_ARL8B	ARL8B	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circARL8B is up-regulated in breast cancer tissues and cells and promotes malignant progression, including cell viability, migration, invasion, fatty acid metabolism and tumor growth. Mechanistically, it sponges miR-653-5p to regulate HMGA2 and may activate the PGE2/PI3K/AKT/GSK-3beta/Wnt/beta-catenin pathway, suggesting potential therapeutic relevance in BC."	0.7581
34050852	Digestive diseases and sciences	2022	Lidocaine Suppresses Gastric Cancer Development Through Circ_ANO5/miR-21-5p/LIFR Axis.	hsa_circ_0021506	circular RNA ANO5 	hsa_circ_ANO5	ANO5	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"circ_ANO5 is downregulated in gastric cancer cells and GC tumor tissues from GSE83521, while lidocaine increases its expression. In this study, circ_ANO5 mediates lidocaine-induced suppression of GC proliferation, migration, invasion, EMT-related changes and xenograft tumor growth, while promoting apoptosis. Mechanistically, circ_ANO5 sponges miR-21-5p to regulate LIFR expression, forming a circ_ANO5/miR-21-5p/LIFR axis."	0.6742
34052126	The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation	2021	Preventing alloimmune rejection using circular RNA FSCN1-silenced dendritic cells in heart transplantation.		circular RNA FSCN1 	mmu_circ_FSCN1		alloimmune rejection 	MONDO:1010185	transplant rejection	up-regulated	RT-qPCR; Microarray	"This study identifies mouse circFSCN1 as a cytoplasmic circRNA enriched in mature dendritic cells and functionally linked to DC maturation. circFSCN1 interacts with EF1A and supports EF1A/p-p65-associated DC activation; silencing circFSCN1 generates tolerogenic DCs that suppress T-cell activation, increase Tregs, reduce alloimmune rejection, and prolong cardiac allograft survival in a mouse heart transplantation model."	0.7726
34052308	Toxicology letters	2021	"The Circ_CARM1 controls cell migration by regulating CTNNBIP1 in anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9,10-epoxide-transformed 16HBE cells."	hsa_circ_0004552	circ_CARM1	hsa_circ_CARM1	CARM1	lung cancer 	MONDO:0008903	lung cancer	down-regulated	RT-qPCR; Microarray	Circ_CARM1 is down-regulated in anti-BPDE-induced malignant transformed 16HBE cells and in some lung cancer cell lines. It mainly inhibits cell migration rather than proliferation or apoptosis by sponging miR-1288-3p and increasing CTNNBIP1 mRNA/protein expression.	0.7347
34056735	Drug development research	2021	"CircMYLK promotes the growth, migration, invasion, and survival of bladder cancer cells by upregulating CCND3 level via competitively binding to miR-34a."	hsa_circ_0067049	circMYLK 	hsa_circ_MYLK	MYLK	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"CircMYLK/circ_0067049 is up-regulated in human bladder cancer tissues and cell lines. It promotes malignant bladder cancer cell behaviors, including growth, migration, invasion, and survival, while inhibiting apoptosis and cell cycle arrest. Mechanistically, cytoplasmic circMYLK competitively binds miR-34a and increases CCND3 expression through a ceRNA regulatory network."	0.7283
34061329	Genes & genomics	2021	Circ_0001666 affects miR-620/WNK2 axis to inhibit breast cancer progression.	hsa_circ_0001666	circ_0001666 			breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	"This study identified circ_0001666 as a downregulated circRNA in breast cancer tissues and cell lines. Functional assays showed that circ_0001666 suppresses breast cancer progression by inhibiting proliferation, migration, invasion, metastasis-related phenotypes and tumor growth, while promoting apoptosis. Mechanistically, circ_0001666 acts as a miR-620 sponge to upregulate WNK2 in a circ_0001666/miR-620/WNK2 ceRNA axis."	0.7799
34061424	Oral diseases	2023	Expression profile and bioinformatics analysis of circular RNAs in tongue squamous cell carcinoma.	hsa_circ_0005035				tongue squamous cell carcinoma 	MONDO:0000500	tongue squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005035 was significantly up-regulated in TSCC tissues and was also increased in SCC9 and SCC25 cells compared with HOK cells. The study validated its expression by qRT-PCR and suggested it may serve as a diagnostic biomarker and potential therapeutic target, with mechanisms predicted through a circRNA-miRNA-mRNA network."	0.559
34061424	Oral diseases	2023	Expression profile and bioinformatics analysis of circular RNAs in tongue squamous cell carcinoma.	hsa_circ_0002360				tongue squamous cell carcinoma 	MONDO:0000500	tongue squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0002360 was significantly up-regulated in TSCC tissues and highly expressed in CAL27, SCC9, and SCC25 cells compared with HOK cells. It showed the highest reported diagnostic AUC among the four validated circRNAs and was proposed as a potential TSCC biomarker, with a predicted role in a circRNA-miRNA-mRNA network."	0.559
34061424	Oral diseases	2023	Expression profile and bioinformatics analysis of circular RNAs in tongue squamous cell carcinoma.	hsa_circ_0066251				tongue squamous cell carcinoma 	MONDO:0000500	tongue squamous cell carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0066251 was significantly down-regulated in TSCC tissues and expressed at lower levels in CAL27 and SCC25 cells compared with HOK cells. The study validated this change by qRT-PCR and suggested diagnostic biomarker potential, while its mechanism was predicted using a circRNA-miRNA-mRNA network."	0.559
34061424	Oral diseases	2023	Expression profile and bioinformatics analysis of circular RNAs in tongue squamous cell carcinoma.	hsa_circ_0003161				tongue squamous cell carcinoma 	MONDO:0000500	tongue squamous cell carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0003161 was significantly down-regulated in TSCC tissues and in CAL27, SCC9, and SCC25 cells compared with HOK cells. Its expression pattern was validated by qRT-PCR, and ROC analysis suggested potential diagnostic value for TSCC; the study predicted its possible mechanism through a circRNA-miRNA-mRNA network."	0.559
34076278	European journal of clinical investigation	2021	Circ_0021087 acts as a miR-184 sponge and represses gastric cancer progression by adsorbing miR-184 and elevating FOSB expression.	hsa_circ_0021087	circ_0021087	hsa_circ_LMO1	LMO1	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"In gastric cancer, hsa_circ_0021087/circ_0021087 is down-regulated and functions as a tumor suppressor. It sponges miR-184 to increase FOSB expression, thereby inhibiting proliferation, EMT, migration, invasion and xenograft growth while promoting apoptosis."	0.7552
34081812	Molecular carcinogenesis	2021	CircSPAG16 suppresses cadmium-induced transformation of human bronchial epithelial cells by decoying PIP5K1alpha to inactivate Akt.		circSPAG16 	hsa_circ_SPAG16	SPAG16	cadmium-induced lung carcinogenesis 	MONDO:0021117	lung neoplasm	down-regulated	RT-qPCR; RNA-seq	"CircSPAG16 is significantly downregulated during cadmium-induced transformation of human bronchial epithelial BEAS-2B cells and in lung cancer cell lines. It functions as a suppressive circRNA by directly binding PIP5K1alpha, inhibiting PIP5K1alpha/Akt signaling, and reducing proliferation, migration, invasion, anchorage-independent growth, and cadmium-induced transformation."	0.7626
34082244	Ecotoxicology and environmental safety	2021	Circ-SHPRH suppresses cadmium-induced transformation of human bronchial epithelial cells by regulating QKI expression via miR-224-5p.		circ-SHPRH	hsa_circ_SHPRH	SHPRH	cadmium-induced transformation of human bronchial epithelial cells 	MONDO:0021117	lung neoplasm	down-regulated	RT-qPCR	"circ-SHPRH is down-regulated during the middle and late stages of cadmium-induced transformation of human bronchial epithelial BEAS-2B cells. Functionally, circ-SHPRH suppresses proliferation, EMT, migration, invasion, and anchorage-independent growth by sponging miR-224-5p to restore QKI expression. The study also supports a positive-feedback loop between QKI and circ-SHPRH under cadmium treatment, suggesting circ-SHPRH as a potential target for preventing or treating cadmium-induced lung cancer."	0.717
34085163	Inflammation	2021	Circular RNA circHIPK3 Activates Macrophage NLRP3 Inflammasome and TLR4 Pathway in Gouty Arthritis via Sponging miR-561 and miR-192.		circRNA HIPK3 	hsa_circ_HIPK3	HIPK3	gouty arthritis 	MONDO:0005393	gout	up-regulated	RT-qPCR; RNA-seq	"circHIPK3 is up-regulated in SFMCs from patients with gouty arthritis and in MSU-stimulated THP-1 cells. It promotes inflammatory cytokine production and inflammatory signaling by sponging miR-192 and miR-561, thereby increasing TLR4 and NLRP3 expression. Knockdown of circHIPK3 suppresses gouty arthritis in an MSU-induced mouse model, suggesting therapeutic potential."	0.7372
34085707	European journal of clinical investigation	2021	Circ-ACAP2 facilitates the progression of colorectal cancer through mediating miR-143-3p/FZD4 axis.		"circRNA ArfGAP with coiled-coil, ankyrin repeat and PH domains 2"	hsa_circ_ACAP2	ACAP2	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	Circ-ACAP2 is up-regulated in colorectal cancer tissues and cell lines. It promotes malignant CRC phenotypes and radioresistance while suppressing apoptosis by sponging miR-143-3p to increase FZD4 expression and modulate Wnt/beta-catenin signalling. Silencing circ-ACAP2 increases radiosensitivity and suppresses tumor growth in a SW480 xenograft model.	0.6542
34089272	Journal of clinical laboratory analysis	2021	Hsa_circ_0031787 promotes cell proliferation and invasion in colorectal cancer.	hsa_circ_0031787		hsa_circ_POLE2	POLE2	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0031787 is up-regulated in colorectal cancer tissues and cell lines and is associated with advanced TNM stage and lymph node metastasis. Functionally, it promotes CRC cell proliferation, colony formation, invasion, and tumor growth in vivo. Mechanistically, the study indicates that hsa_circ_0031787 activates Wnt/beta-catenin signaling, with effects on Cyclin D1 and Axin2."	0.7795
34089702	Brain research	2021	Sevoflurane suppresses glioma tumorigenesis via regulating circ_0079593/miR-633/ROCK1 axis.	hsa_circ_0079593	circ_0079593			glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ_0079593 is upregulated in glioma and acts as an oncogenic circRNA. It sponges miR-633 to relieve repression of ROCK1, thereby counteracting the anti-tumor effects of sevoflurane and promoting glioma cell proliferation, migration, invasion, EMT, and tumor growth."	0.6837
34091391	"Pathology, research and practice"	2021	Circ_0084615 is an oncogenic circular RNA in colorectal cancer and promotes DNMT3A expression via repressing miR-599.	hsa_circ_0084615	circ_0084615 	hsa_circ_ASPH	ASPH	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"Circ_0084615 is an ASPH-derived human circRNA up-regulated in colorectal cancer tissues and cell lines. It promotes CRC proliferation, migration, invasion and lung metastatic colonization by acting as a ceRNA that sponges miR-599 and increases DNMT3A expression. Clinically, high circ_0084615 expression is associated with worse overall survival and higher TNM stage, suggesting biomarker and therapeutic-target potential."	0.7486
34092624	Clinical hemorheology and microcirculation	2022	Circular RNA circLMF1 regulates PDGF-BB-induced proliferation and migration of human aortic smooth muscle cells by regulating the miR-125a-3p/VEGFA or FGF1 axis.		circRNA lipase maturation factor 1	hsa_circ_LMF1	LMF1	atherosclerosis	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR; Microarray	"circLMF1 is up-regulated in proliferative and PDGF-BB-stimulated human aortic smooth muscle cells. It promotes HASMC viability, cell cycle progression, proliferation, and migration by sponging miR-125a-3p and relieving repression of VEGFA and FGF1, suggesting a potential therapeutic target in atherosclerosis."	0.809
34096368	European journal of ophthalmology	2022	"Circ_0000615 promotes high glucose-induced human retinal pigment epithelium cell apoptosis, inflammation and oxidative stress via miR-646/YAP1 axis in diabetic retinopathy."	hsa_circ_0000615	circ_0000615	hsa_circ_ZNF609	ZNF609	diabetic retinopathy 	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR	"circ_0000615 is up-regulated in high glucose-induced ARPE-19 cells, an in vitro DR cell model. It promotes HRPE cell dysfunction, including apoptosis, inflammation and ROS generation, by sponging miR-646 and thereby regulating YAP1 expression. The study suggests circ_0000615 as a potential therapeutic target for diabetic retinopathy."	0.7822
34096408	Autoimmunity	2021	"CircRAB3B suppresses proliferation, motility, cell cycle progression and promotes the apoptosis of IL-22-induced keratinocytes depending on the regulation of miR-1228-3p/PTEN axis in psoriasis."		circRAB3B 	hsa_circ_RAB3B	RAB3B	psoriasis	MONDO:0005083	psoriasis	down-regulated	RT-qPCR	"CircRAB3B is down-regulated in psoriatic skin samples and IL-22-treated HaCaT cells. Its overexpression suppresses keratinocyte proliferation, migration, invasion and cell cycle progression while promoting apoptosis, partly by sponging miR-1228-3p and increasing PTEN expression. The circRAB3B/miR-1228-3p/PTEN axis is proposed as a potential therapeutic target in psoriasis."	0.7597
34097310	Hematological oncology	2021	Downregulation of circ_0012152 inhibits proliferation and induces apoptosis in acute myeloid leukemia cells through the miR-625-5p/SOX12 axis.	hsa_circ_0012152	circ_0012152 	hsa_circ_RNF220	RNF220	acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"circ_0012152 is upregulated in AML tissues and cell lines and high expression is associated with poorer overall survival. Functionally, circ_0012152 promotes AML cell proliferation and cell-cycle progression while inhibiting cell death/apoptosis. Mechanistically, it acts through the miR-625-5p/SOX12 axis by suppressing miR-625-5p activity and increasing SOX12 expression."	0.7789
34097558	"Cell cycle (Georgetown, Tex.)"	2021	Hsa_circ_0044235 regulates the pyroptosis of rheumatoid arthritis via MiR-135b-5p-SIRT1 axis.	hsa_circ_0044235				rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	down-regulated	RT-qPCR	"hsa_circ_0044235 is down-regulated in the serum of RA patients. In CIA mice and LPS/ATP-induced FLSs, hsa_circ_0044235 overexpression alleviates inflammation, apoptosis and joint damage and suppresses NLRP3-mediated pyroptosis. Mechanistically, hsa_circ_0044235 sponges miR-135b-5p to promote SIRT1 expression, forming a hsa_circ_0044235/miR-135b-5p/SIRT1 axis involved in RA progression."	0.7183
34097560	"Cell cycle (Georgetown, Tex.)"	2021	CircPUM1 promotes cell growth and glycolysis in NSCLC via up-regulating METTL3 expression through miR-590-5p.		circPUM1 	hsa_circ_PUM1	PUM1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circPUM1 is up-regulated in NSCLC tissues and cell lines, and high expression is associated with advanced TNM stage and poorer overall survival. Functionally, circPUM1 promotes NSCLC proliferation, cell cycle progression, glycolysis and xenograft tumor growth by sponging miR-590-5p and increasing METTL3 expression."	0.8322
34101064	Journal of molecular histology	2021	Circ_0091702 serves as a sponge of miR-545-3p to attenuate sepsis-related acute kidney injury by upregulating THBS2.	hsa_circ_0091702	circ_0091702 	hsa_circ_VMA21	VMA21	sepsis-related acute kidney injury 	MONDO:0005229	bacterial infectious disease with sepsis	down-regulated	RT-qPCR	"Circ_0091702 is down-regulated in serum from septic AKI patients and in LPS-induced HK2 cell models. It protects HK2 cells from LPS-induced injury by suppressing apoptosis, inflammatory responses and oxidative stress, mechanistically acting as a sponge for miR-545-3p to upregulate THBS2. The study suggests circ_0091702 as a potential biomarker or therapeutic target for sepsis-induced AKI."	0.7032
34102206	Experimental eye research	2021	Circular RNA circ-FAM158A promotes retinoblastoma progression by regulating miR-138-5p/SLC7A5 axis.		circ-FAM158A 	hsa_circ_FAM158A		retinoblastoma 	MONDO:0008380	retinoblastoma	up-regulated	RT-qPCR	"circ-FAM158A is up-regulated in retinoblastoma tissues and cell lines. It promotes RB progression by enhancing proliferation, migration, invasion, tumor growth and metastasis while suppressing apoptosis, mainly through the circ-FAM158A/miR-138-5p/SLC7A5 ceRNA axis. The study suggests circ-FAM158A may be a potential therapeutic target and possible prognosis marker in RB."	0.7861
34105224	The journal of gene medicine	2021	Circular RNA circ_0001588 sponges miR-211-5p to facilitate the progression of glioblastoma via up-regulating YY1 expression.	hsa_circ_0001588	circ_0001588	hsa_circ_HIST1H4E	HIST1H4E	glioblastoma 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR	"circ_0001588 is up-regulated in GBM tissues and glioma cell lines, and high expression is associated with poor patient survival. Functionally, circ_0001588 promotes GBM proliferation, migration, invasion and xenograft tumor growth. Mechanistically, it acts as a cytoplasmic ceRNA that sponges miR-211-5p to increase YY1 expression."	0.8768
34116208	Pharmacological research	2021	The role of circTmeff-1 in incubation of context-induced morphine craving.	mmu_circ_0011663	CircTmeff-1	mmu_circ_Tmeff-1	Tmeff-1	incubation of context-induced morphine craving 	MONDO:0005531	morphine dependence	up-regulated	RT-qPCR; ISH; RNA-seq	"circTmeff-1 is a mouse circRNA derived from Tmeff-1 that is up-regulated in the NAc core during incubation of context-induced morphine craving. It promotes craving incubation by sponging miR-541-5p and miR-6934-3p and is associated with increased VAMP1 and NFASC expression, making it a potential therapeutic target for opioid craving relapse prevention."	0.7621
34116208	Pharmacological research	2021	The role of circTmeff-1 in incubation of context-induced morphine craving.		circDmxl2	mmu_circ_Dmxl2	Dmxl2	incubation of context-induced morphine craving 	MONDO:0005531	morphine dependence	up-regulated	RT-qPCR; RNA-seq	circDmxl2 was identified by RNA sequencing and validated by qRT-PCR as up-regulated in mouse NAc tissue during incubation of context-induced morphine craving. The study did not further investigate its mechanism or functional contribution.	0.4468
34116208	Pharmacological research	2021	The role of circTmeff-1 in incubation of context-induced morphine craving.		circPik3c2a	mmu_circ_Pik3c2a	Pik3c2a	incubation of context-induced morphine craving 	MONDO:0005531	morphine dependence	up-regulated	RT-qPCR; RNA-seq	circPik3c2a was identified by RNA sequencing and validated by qRT-PCR as up-regulated in mouse NAc tissue during incubation of context-induced morphine craving. The study did not further investigate its mechanism or functional contribution.	0.4468
34117589	Molecular and cellular biochemistry	2021	Knockdown of circ_0075503 suppresses cell migration and invasion by regulating miR-15a-5p and KLF12 in endometriosis.	hsa_circ_0075503	circ_0075503	hsa_circ_SLC22A23	SLC22A23	endometriosis 	MONDO:0005133	endometriosis	up-regulated	RT-qPCR	"circ_0075503 is up-regulated in ectopic endometrium and ectopic ESCs from endometriosis patients. Functionally, circ_0075503 promotes E2-induced ESC viability, migration, invasion and EMT-like marker changes, while its knockdown suppresses these phenotypes. Mechanistically, circ_0075503 sponges miR-15a-5p to increase KLF12 expression, forming a circ_0075503/miR-15a-5p/KLF12 regulatory axis with potential therapeutic relevance."	0.7551
34119765	Cancer treatment and research communications	2021	Tumor-derived exosomal circFARSA mediates M2 macrophage polarization via the PTEN/PI3K/AKT pathway to promote non-small cell lung cancer metastasis.		circFARSA 	hsa_circ_FARSA	FARSA	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circFARSA is upregulated in NSCLC tissues and cell lines and promotes NSCLC migration, invasion, EMT and metastasis. Tumor-derived exosomal circFARSA is taken up by macrophages, induces M2 polarization through PTEN ubiquitination/degradation and PI3K/AKT activation, and may serve as a diagnostic/prognostic biomarker for NSCLC."	0.8271
34119822	Biochemical and biophysical research communications	2021	circ_0001461 promotes oral squamous cell carcinoma progression through miR-145/TLR4/NF-kappaB axis.	hsa_circ_0001461	circ_0001461	hsa_circ_FAT1	FAT1	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circ_0001461 is up-regulated in OSCC tissues and cell lines and acts as an oncogenic circRNA. It promotes proliferation, migration, invasion, xenograft tumor growth, and resistance to TNF-a-induced apoptosis through a miR-145/TLR4/NF-kB regulatory axis. The study suggests circ_0001461 may be a potential biomarker and therapeutic target for OSCC."	0.8119
34129971	World neurosurgery	2021	Propofol Represses Cell Growth and Metastasis by Modulating the Circular RNA Non-SMC Condensin I Complex Subunit G/MicroRNA-200a-3p/RAB5A Axis in Glioma.	hsa_circ_0007244	circNCAPG 	hsa_circ_NCAPG	NCAPG	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circNCAPG is up-regulated in glioma tissues and cells and is reduced by propofol treatment. Functionally, circNCAPG promotes glioma cell proliferation, migration, invasion and tumor growth while suppressing apoptosis, thereby counteracting propofol-mediated anti-glioma effects. Mechanistically, circNCAPG sponges miR-200a-3p to positively regulate RAB5A in the circNCAPG/miR-200a-3p/RAB5A axis."	0.7052
34132956	Biochemical genetics	2022	Circ_0072995 Promotes Ovarian Cancer Progression Through Regulating miR-122-5p/SLC1A5 Axis.	hsa_circ_0072995	circ_0072995			Ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circ_0072995 is up-regulated in ovarian cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation, migration, invasion, cell cycle progression and xenograft tumor growth while suppressing apoptosis by sponging miR-122-5p and up-regulating SLC1A5."	0.78
34139239	Experimental and molecular pathology	2021	"Elevated circRNAs circ_0000745, circ_0001531 and circ_0001640 in human whole blood: Potential novel diagnostic biomarkers for breast cancer."	hsa_circ_0000745	circ_0000745			breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0000745 was significantly up-regulated in whole blood from breast cancer patients and showed diagnostic value in ROC analyses. The study suggests circ_0000745 may act as part of a predicted circRNA-miRNA-mRNA network and may contribute to breast cancer-related regulatory processes, but functional mechanisms were not experimentally validated."	0.459
34139239	Experimental and molecular pathology	2021	"Elevated circRNAs circ_0000745, circ_0001531 and circ_0001640 in human whole blood: Potential novel diagnostic biomarkers for breast cancer."	hsa_circ_0001531	circ_0001531			breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0001531 was significantly up-regulated in whole blood from breast cancer patients and showed diagnostic value in ROC analyses. The study suggests circ_0001531 may act as part of a predicted circRNA-miRNA-mRNA network and may contribute to breast cancer-related regulatory processes, but functional mechanisms were not experimentally validated."	0.459
34139239	Experimental and molecular pathology	2021	"Elevated circRNAs circ_0000745, circ_0001531 and circ_0001640 in human whole blood: Potential novel diagnostic biomarkers for breast cancer."	hsa_circ_0001640	circ_0001640			breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0001640 was significantly up-regulated in whole blood from breast cancer patients and showed diagnostic value in ROC analyses. Its expression correlated positively with Ki-67 level and varied among breast cancer subtypes, with highest expression in HER2+ cancer and lowest in triple-negative cancer. The study suggests circ_0001640 may act through a predicted circRNA-miRNA-mRNA network, but mechanistic functions were not experimentally validated."	0.459
34139933	Journal of receptor and signal transduction research	2022	Curcumin restrains hepatocellular carcinoma progression depending on the regulation of the circ_0078710/miR-378b/PRIM2 axis.	hsa_circ_0078710				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0078710 is up-regulated in HCC cell lines and is reduced by curcumin treatment. Functionally, circ_0078710 silencing enhances curcumin-mediated suppression of proliferation, migration, invasion and xenograft tumor growth, while promoting apoptosis. Mechanistically, circ_0078710 sponges miR-378b to positively regulate PRIM2 in the circ_0078710/miR-378b/PRIM2 axis."	0.7289
34142340	Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico	2021	Circular RNA circHIPK3 modulates prostate cancer progression via targeting miR-448/MTDH signaling.		circHIPK3	hsa_circ_HIPK3	HIPK3	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circHIPK3 is upregulated in prostate cancer tissues and cell lines. It promotes PCa cell proliferation, migration, invasion, and xenograft tumor growth by sponging miR-448 and enhancing MTDH expression, suggesting an oncogenic role and potential therapeutic relevance."	0.7177
34143288	Archives of dermatological research	2022	Hsa_circ_0008234 facilitates proliferation of cutaneous squamous cell carcinoma through targeting miR-127-5p to regulate ADCY7.	hsa_circ_0008234	circ_0008234	hsa_circ_FOXP1	FOXP1	cutaneous squamous cell carcinoma 	MONDO:0002529	skin squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0008234 is up-regulated in cSCC tissues and is mainly localized in the cytoplasm. It promotes cSCC cell proliferation by sponging miR-127-5p and thereby regulating ADCY7 expression, suggesting potential therapeutic relevance."	0.8386
34143288	Archives of dermatological research	2022	Hsa_circ_0008234 facilitates proliferation of cutaneous squamous cell carcinoma through targeting miR-127-5p to regulate ADCY7.	hsa_circ_0002891	circ_0002891			cutaneous squamous cell carcinoma 	MONDO:0002529	skin squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circ_0002891 was identified among the top three circRNAs significantly up-regulated in cSCC tissues in the GSE74758 microarray analysis and was included in the qRT-PCR expression assessment of paired cSCC and non-lesional skin tissues. No functional mechanism was reported for this circRNA in the study.	0.4032
34143288	Archives of dermatological research	2022	Hsa_circ_0008234 facilitates proliferation of cutaneous squamous cell carcinoma through targeting miR-127-5p to regulate ADCY7.	hsa_circ_0001402	circ_0001402			cutaneous squamous cell carcinoma 	MONDO:0002529	skin squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circ_0001402 was identified among the top three circRNAs significantly up-regulated in cSCC tissues in the GSE74758 microarray analysis and was included in the qRT-PCR expression assessment of paired cSCC and non-lesional skin tissues. No functional mechanism was reported for this circRNA in the study.	0.4032
34144504	Biochemical and biophysical research communications	2021	circSNX6 (hsa_circ_0031608) enhances drug resistance of non-small cell lung cancer (NSCLC) via miR-137.	hsa_circ_0031608	circSNX6	hsa_circ_SNX6	SNX6	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	unknown	RT-qPCR	"This study identifies circSNX6 as a promoter of cisplatin resistance in NSCLC cells. circSNX6 enhances cell viability, proliferation, and xenograft tumor growth while inhibiting apoptosis under cisplatin treatment, acting through a proposed circSNX6/miR-137/ROS/CXCL12 axis."	0.4635
34146216	Metabolic brain disease	2021	Circ_0006768 upregulation attenuates oxygen-glucose deprivation/reoxygenation-induced human brain microvascular endothelial cell injuries by upregulating VEZF1 via miR-222-3p inhibition.	hsa_circ_0006768	circ_0006768	hsa_circ_ZNF292	ZNF292	ischemic stroke 	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR; Microarray	"Circ_0006768 is downregulated in ischemic stroke plasma and OGD/R-induced HBMECs. Its overexpression protects HBMECs from OGD/R-induced injury by enhancing viability, angiogenesis and migration while suppressing inflammatory cytokine release. Mechanistically, circ_0006768 sponges miR-222-3p to upregulate VEZF1, suggesting therapeutic potential in ischemic stroke."	0.7629
34148288	IUBMB life	2021	Circ_0072088 promotes progression of hepatocellular carcinoma by activating JAK2/STAT3 signaling pathway via miR-375.	hsa_circ_0072088	circ_0072088	hsa_circ_ZFR	ZFR	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0072088 is up-regulated in HCC tissues and cell lines and is mainly cytoplasmic. It promotes HCC cell proliferation, migration, and invasion while inhibiting apoptosis by sponging miR-375 and activating the JAK2/STAT3 signaling pathway. Its expression is associated with aggressive clinicopathological characteristics, suggesting potential biomarker or therapeutic-target value."	0.7785
34151476	The journal of gene medicine	2021	Down-regulation of circITCH promotes osteosarcoma development and resistance to doxorubicin via the miR-524/RASSF6 axis.		circRNA itchy E3 ubiquitin protein ligase 	hsa_circ_ITCH	ITCH	osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR	"circITCH is down-regulated in osteosarcoma tissues, OS cell lines, and doxorubicin-resistant samples/cells. Its overexpression suppresses OS malignant phenotypes and doxorubicin resistance by sponging miR-524 to up-regulate RASSF6, and it also reduces xenograft tumor growth in vivo."	0.7795
34151690	Experimental lung research	2021	The role of circTMOD3 in regulating LPS-induced acute inflammation and injury in human lung fibroblast WI-38 cells.	hsa_circ_0035292	circRNA tropomodulin 3 	hsa_circ_TMOD3	TMOD3	pediatric pneumonia 	MONDO:0005249	pneumonia	up-regulated	RT-qPCR	"circTMOD3 is up-regulated in LPS-treated human WI-38 lung fibroblasts and contributes to LPS-induced inflammatory injury. Its knockdown alleviates reduced viability, apoptosis, cell cycle arrest, and inflammatory cytokine production. Mechanistically, circTMOD3 functions as a ceRNA for miR-146b-3p to increase CXCR1 expression."	0.7626
34151713	Journal of receptor and signal transduction research	2022	"Emodin alleviates high glucose-induced oxidative stress, inflammation and extracellular matrix accumulation of mesangial cells by the circ_0000064/miR-30c-5p/Lmp7 axis."	mmu_circ_0000064	circ_0000064	mmu_circ_Hdac4	Hdac4	diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"In a high glucose-induced mesangial cell model of diabetic nephropathy, circ_0000064 was up-regulated and acted as a downstream effector opposed by emodin. circ_0000064 promoted oxidative stress, inflammation and extracellular matrix accumulation by targeting miR-30c-5p and regulating Lmp7, with NF-kappaB and PI3K/AKT pathways implicated downstream."	0.6716
34152928	"Cell cycle (Georgetown, Tex.)"	2021	Circular RNA circHIPK3 promotes breast cancer progression via sponging MiR-326.			hsa_circ_HIPK3	HIPK3	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in breast cancer tissues and cell lines and acts as an oncogenic circRNA. It promotes proliferation, migration, invasion, EMT-like marker changes, apoptosis resistance and xenograft tumor growth by sponging miR-326 and regulating apoptosis- and metastasis-related proteins. The study proposes circHIPK3 as a potential therapeutic target for breast cancer."	0.8175
34159479	Molecular and cellular biochemistry	2021	Circular RNA circUBR4 regulates ox-LDL-induced proliferation and migration of vascular smooth muscle cells through miR-185-5p/FRS2 axis.	hsa_circ_0010283	circUBR4 	hsa_circ_UBR4	UBR4	atherosclerosis	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"circUBR4 is up-regulated in serum from atherosclerosis patients and in ox-LDL-treated human VSMCs. It promotes VSMC proliferation and migration by acting through the miR-185-5p/FRS2 axis, and its inhibition suppresses ox-LDL-induced pathological VSMC phenotypes. The study suggests circUBR4 as a potential biomarker or intervention target for atherosclerosis."	0.8122
34164767	Journal of bioenergetics and biomembranes	2021	Downregulation of hsa_circ_0001681 suppresses epithelial-mesenchymal transition in thyroid carcinoma via targeting to miR-942-5p/TWIST1 signaling pathway.	hsa_circ_0001681				Thyroid carcinoma 	MONDO:0015075	thyroid gland carcinoma	up-regulated	RT-qPCR	"hsa_circ_0001681 is up-regulated in thyroid carcinoma tissues and cell lines and is mainly localized in the cytoplasm. It promotes TC cell proliferation, migration, invasion, EMT and xenograft tumor growth by acting as a miR-942-5p sponge to increase TWIST1 expression. The study suggests hsa_circ_0001681 as a potential therapeutic target or biomarker for TC treatment."	0.6521
34164774	Human cell	2021	Circular RNA circ-CHI3L1.2 modulates cisplatin resistance of osteosarcoma cells via the miR-340-5p/LPAATbeta axis.		circ-CHI3L1.2 	hsa_circ_CHI3L1	CHI3L1	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ-CHI3L1.2 is up-regulated in cisplatin-resistant osteosarcoma cell lines compared with parental cells. Functionally, circ-CHI3L1.2 promotes cisplatin resistance, migration, invasion and EMT-like features while suppressing apoptosis; its knockdown sensitizes resistant cells to cisplatin. Mechanistically, it acts as a ceRNA for miR-340-5p to regulate the LPAATbeta axis."	0.717
34181173	Journal of molecular histology	2021	Inhibiting of circ-TLK1 inhibits the progression of glioma through down-regulating PANX1 via targeting miR-17-5p.			hsa_circ_TLK1	TLK1	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"Circ-TLK1 is up-regulated in glioma tissues and cell lines and high expression is associated with larger tumor volume, higher grade, and poorer survival. Functionally, Circ-TLK1 promotes glioma proliferation, migration, invasion, metastasis and in vivo tumor growth while inhibiting apoptosis. Mechanistically, it sponges miR-17-5p to up-regulate PANX1 and activate MAPK/ERK signaling."	0.7412
34189997	"Cell cycle (Georgetown, Tex.)"	2021	"Circ_0006988 promotes the proliferation, metastasis and angiogenesis of non-small cell lung cancer cells by modulating miR-491-5p/MAP3K3 axis."	hsa_circ_0006988	circ_0006988 	hsa_circ_LDLRAD3	LDLRAD3	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"Circ_0006988 is up-regulated in NSCLC tissues and cells and acts as an oncogenic circRNA. It promotes proliferation, migration, invasion, angiogenesis and tumor growth while suppressing apoptosis. Mechanistically, circ_0006988 sponges miR-491-5p to increase MAP3K3 expression, forming a circ_0006988/miR-491-5p/MAP3K3 regulatory axis."	0.8443
34191363	The journal of gene medicine	2022	Inhibition of circ_0081234 reduces prostate cancer tumor growth and metastasis via the miR-1/MAP 3 K1 axis.	hsa_circ_0081234	circ_0081234		TRRAP	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circ_0081234 is an exosomal circRNA up-regulated in spinal metastatic prostate cancer. It promotes PCa migration, invasion, EMT, and tumor growth by sponging miR-1 and thereby increasing MAP3K1 expression."	0.6672
34216220	Inflammation research : official journal of the European Histamine Research Society ... [et al.]	2021	CircRNA circ-ITCH improves renal inflammation and fibrosis in streptozotocin-induced diabetic mice by regulating the miR-33a-5p/SIRT6 axis.		circ-ITCH 	mmu_circ_ITCH	ITCH	Diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	down-regulated	RT-qPCR	"circ-ITCH was downregulated in high-glucose-induced RMCs. Its overexpression suppressed RMC viability, migration, fibrosis and inflammatory responses, and improved renal inflammation and fibrosis in STZ-induced diabetic mice. Mechanistically, circ-ITCH acted as a sponge for miR-33a-5p to regulate SIRT6 expression."	0.6006
34216220	Inflammation research : official journal of the European Histamine Research Society ... [et al.]	2021	CircRNA circ-ITCH improves renal inflammation and fibrosis in streptozotocin-induced diabetic mice by regulating the miR-33a-5p/SIRT6 axis.		circ-ITCH 	rno_circ_ITCH	ITCH	Diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	down-regulated	RT-qPCR	"circ-ITCH was downregulated in high-glucose-induced RMCs. Its overexpression suppressed RMC viability, migration, fibrosis and inflammatory responses, and improved renal inflammation and fibrosis in STZ-induced diabetic mice. Mechanistically, circ-ITCH acted as a sponge for miR-33a-5p to regulate SIRT6 expression."	0.6006
34219206	Biochemical genetics	2022	Circ-TFF1 Facilitates Breast Cancer Development via Regulation of miR-338-3p/FGFR1 Axis.	hsa_circ_0061825	circRNA trefoil factor 1 	hsa_circ_TFF1	TFF1	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"Circ-TFF1 is up-regulated in breast cancer tissues and cell lines and acts as an oncogenic circRNA. Mechanistically, cytoplasmic circ-TFF1 sponges miR-338-3p to increase FGFR1 expression, thereby promoting proliferation, invasion, glycolysis and tumor growth while suppressing apoptosis. Its knockdown suppresses breast cancer progression, suggesting therapeutic potential."	0.8175
34223793	"Cell cycle (Georgetown, Tex.)"	2021	Hsa_circ_0008360 sponges miR-186-5p to target CCND2 to modulate high glucose-induced vascular endothelial dysfunction.	hsa_circ_0008360	circ_0008360	hsa_circ_XPNPEP3	XPNPEP3	high glucose-induced vascular endothelial dysfunction 	MONDO:0005015	diabetes mellitus	up-regulated	RT-qPCR	"Hsa_circ_0008360 is up-regulated in high glucose-treated HUVEC and aggravates vascular endothelial dysfunction by reducing viability, migration and tube formation while promoting apoptosis. Mechanistically, it sponges miR-186-5p to regulate CCND2 through a ceRNA-based circ_0008360/miR-186-5p/CCND2 axis, suggesting therapeutic potential for vascular endothelial dysfunction-related disorders."	0.721
34225215	"Pathology, research and practice"	2021	Circular RNA PLEC acts as a sponge of microRNA-198 to promote gastric carcinoma cell resistance to paclitaxel and tumorigenesis.		circPLEC 	hsa_circ_PLEC	PLEC	gastric carcinoma 	MONDO:0004950	gastric carcinoma	up-regulated	RT-qPCR	"circPLEC is upregulated in gastric carcinoma tissues, especially PTX-resistant GC tissues, and in PTX-resistant GC cell models. Functionally, circPLEC promotes paclitaxel resistance, tumorigenesis, cell viability, migration and invasion while suppressing apoptosis. Mechanistically, it acts as a sponge for miR-198 to increase MUC19 expression, forming a circPLEC/miR-198/MUC19 axis with potential diagnostic and therapeutic relevance."	0.7581
34226983	Neurochemical research	2021	Circ_0003423 Alleviates ox-LDL-Induced Human Brain Microvascular Endothelial Cell Injury via the miR-589-5p/TET2 Network.	hsa_circ_0003423	circ_0003423	hsa_circ_ZNF532	ZNF532	cerebrovascular diseases 	MONDO:0011057	cerebrovascular disorder	down-regulated	RT-qPCR	"circ_0003423 is down-regulated in ox-LDL-induced human BMEC injury models. Its overexpression protects HBMEC-IM cells by enhancing viability and angiogenesis and suppressing apoptosis, oxidative stress, inflammation and ER stress through the miR-589-5p/TET2 axis."	0.7992
34227151	Drug development research	2022	Circ_0001667 knockdown blocks cancer progression and attenuates adriamycin resistance by depleting NCOA3 via releasing miR-4458 in breast cancer.	hsa_circ_0001667	circ_0001667	hsa_circ_HEATR2		breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"Circ_0001667 is up-regulated in ADM-resistant breast cancer tissues and cells. Its knockdown suppresses proliferation, migration, invasion, tumor growth and ADM resistance while promoting ADM-induced apoptosis. Mechanistically, circ_0001667 functions through the circ_0001667/miR-4458/NCOA3 axis, acting as a miR-4458 sponge to maintain NCOA3 expression and promote chemoresistant malignant progression."	0.8324
34228324	Human cell	2021	Hsa_circ_0069244 acts as the sponge of miR-346 to inhibit non-small cell lung cancer progression by regulating XPC expression.	hsa_circ_0069244	circ_0069244	hsa_circ_LDB2	LDB2	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"This study identifies circ_0069244 as a down-regulated tumor-suppressive circRNA in NSCLC. It inhibits NSCLC cell proliferation, migration and in vivo lung metastasis by sponging miR-346-5p and increasing XPC expression. Clinically, reduced circ_0069244 expression is associated with shorter overall survival and poor differentiation, supporting its potential as a prognostic biomarker and therapeutic target."	0.8427
34231101	Digestive diseases and sciences	2022	Circular RNA Circ-STIL Contributes to Cell Growth and Metastasis in Hepatocellular Carcinoma via Regulating miR-345-5p/AQP3 Axis.	hsa_circ_0000069	circ-STIL 	hsa_circ_STIL	STIL	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"Circ-STIL is up-regulated in HCC tissues and cell lines and functions as an oncogenic circRNA. It promotes HCC proliferation, migration, invasion and in vivo tumor growth while suppressing apoptosis, mainly through a ceRNA mechanism in which circ-STIL sponges miR-345-5p to increase AQP3 expression. The study suggests circ-STIL as a potential therapeutic target for HCC."	0.8175
34237642	Ecotoxicology and environmental safety	2021	Cadmium promotes apoptosis and inflammation via the circ08409/miR-133a/TGFB2 axis in bovine mammary epithelial cells and mouse mammary gland.		circ08409 			cadmium damage 	MONDO:0043523	cadmium poisoning	up-regulated	RT-qPCR	"circ08409 is up-regulated in cadmium-treated bovine mammary epithelial cells. It binds and adsorbs miR-133a, relieving miR-133a-mediated repression of TGFB2, thereby promoting apoptosis and inflammation while reducing cell proliferation. The study proposes the circ08409/miR-133a/TGFB2 axis as a mechanism mediating cadmium-induced mammary gland damage."	0.6536
34245327	Mammalian genome : official journal of the International Mammalian Genome Society	2021	Circular RNA circNRIP1 plays oncogenic roles in the progression of osteosarcoma.	hsa_circ_0004771	circNRIP1 	hsa_circ_NRIP1	nuclear receptor interaction protein gene	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"circNRIP1 is up-regulated in osteosarcoma tissues and cell lines and acts as an oncogenic circRNA. Functionally, circNRIP1 promotes osteosarcoma cell proliferation and migration and suppresses apoptosis, while high expression is associated with advanced TNM stage, distant metastasis, and poor overall survival. Mechanistically, METTL3 increases circNRIP1 through m6A modification, and circNRIP1 sponges miR-199a to regulate FOXC2 expression."	0.8323
34251586	Irish journal of medical science	2022	Hsa_circRNA_102541 regulates the development of atherosclerosis by targeting miR-296-5p/PLK1 pathway.		hsa_circRNA_102541 			atherosclerosis	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"hsa_circRNA_102541/circRNA_102541 is upregulated in blood or serum samples from patients with atherosclerosis. In HUVECs, circRNA_102541 promotes proliferation and inhibits apoptosis, while its knockdown suppresses proliferation and enhances apoptosis. Mechanistically, circRNA_102541 acts through the miR-296-5p/PLK1 axis and may represent a risk factor and therapeutic candidate for atherosclerosis."	0.6479
34252490	Virus research	2021	Comprehensive analysis of the circRNA expression profile and circRNA-miRNA-mRNA network in the pathogenesis of EV-A71 infection.	hsa_circ_0000179				EV-A71 infection 	MONDO:0005747	enterovirus infectious disease	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000179 was one of six differentially expressed circRNAs selected from the circRNA-seq profile and validated by qRT-PCR. It was up-regulated in EV-A71-infected SH-SY5Y cells, but no individual downstream mechanism was experimentally tested."	0.4761
34252490	Virus research	2021	Comprehensive analysis of the circRNA expression profile and circRNA-miRNA-mRNA network in the pathogenesis of EV-A71 infection.	hsa_circ_0001546				EV-A71 infection 	MONDO:0005747	enterovirus infectious disease	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001546 was one of six differentially expressed circRNAs selected from the circRNA-seq profile and validated by qRT-PCR. It was up-regulated in EV-A71-infected SH-SY5Y cells, but no individual downstream mechanism was experimentally tested."	0.4761
34252490	Virus research	2021	Comprehensive analysis of the circRNA expression profile and circRNA-miRNA-mRNA network in the pathogenesis of EV-A71 infection.	hsa_circ_0059957				EV-A71 infection 	MONDO:0005747	enterovirus infectious disease	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0059957 was one of six differentially expressed circRNAs selected from the circRNA-seq profile and validated by qRT-PCR. It was up-regulated in EV-A71-infected SH-SY5Y cells, but no individual downstream mechanism was experimentally tested."	0.4761
34252490	Virus research	2021	Comprehensive analysis of the circRNA expression profile and circRNA-miRNA-mRNA network in the pathogenesis of EV-A71 infection.	hsa_circ_0001540				EV-A71 infection 	MONDO:0005747	enterovirus infectious disease	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001540 was one of six differentially expressed circRNAs selected from the circRNA-seq profile and validated by qRT-PCR. It was down-regulated in EV-A71-infected SH-SY5Y cells, but no individual downstream mechanism was experimentally tested."	0.4761
34252490	Virus research	2021	Comprehensive analysis of the circRNA expression profile and circRNA-miRNA-mRNA network in the pathogenesis of EV-A71 infection.	hsa_circ_0000849				EV-A71 infection 	MONDO:0005747	enterovirus infectious disease	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000849 was one of six differentially expressed circRNAs selected from the circRNA-seq profile and validated by qRT-PCR. It was down-regulated in EV-A71-infected SH-SY5Y cells, but no individual downstream mechanism was experimentally tested."	0.4761
34252490	Virus research	2021	Comprehensive analysis of the circRNA expression profile and circRNA-miRNA-mRNA network in the pathogenesis of EV-A71 infection.	hsa_circ_0019079				EV-A71 infection 	MONDO:0005747	enterovirus infectious disease	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0019079 was one of six differentially expressed circRNAs selected from the circRNA-seq profile and validated by qRT-PCR. It was down-regulated in EV-A71-infected SH-SY5Y cells, but no individual downstream mechanism was experimentally tested."	0.4761
34252490	Virus research	2021	Comprehensive analysis of the circRNA expression profile and circRNA-miRNA-mRNA network in the pathogenesis of EV-A71 infection.	hsa_circ_0017115				EV-A71 infection 	MONDO:0005747	enterovirus infectious disease	dysregulated	RNA-seq	"hsa_circ_0017115 was identified through RNA-seq and bioinformatics as a key dysregulated circRNA in EV-A71-infected SH-SY5Y cells. The paper proposed a hsa_circ_0017115/hsa-miR-150-5p/EGR1 ceRNA axis linked to the immune system process, but this axis was not experimentally validated beyond sequencing-based analysis."	0.4276
34252490	Virus research	2021	Comprehensive analysis of the circRNA expression profile and circRNA-miRNA-mRNA network in the pathogenesis of EV-A71 infection.	hsa_circ_0005060				EV-A71 infection 	MONDO:0005747	enterovirus infectious disease	dysregulated	RNA-seq	"hsa_circ_0005060 was identified through RNA-seq and bioinformatics as a key dysregulated circRNA in EV-A71-infected SH-SY5Y cells. The paper proposed a hsa_circ_0005060/hsa-miR-4685-5p/MMP2 ceRNA axis linked to the Wnt signaling pathway, but this axis was not experimentally validated beyond sequencing-based analysis."	0.4276
34254279	"Reproductive sciences (Thousand Oaks, Calif.)"	2021	CircRNA circ-ATAD1 Is Upregulated in Cervical Squamous Cell Carcinoma and Regulates Cell Proliferation and Apoptosis by Suppressing the Maturation of miR-218.		circ-ATAD1	hsa_circ_ATAD1	ATAD1	cervical squamous cell carcinoma 	MONDO:0006143	cervical squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circ-ATAD1 is upregulated in cervical squamous cell carcinoma tissues and is localized in both the nucleus and cytoplasm. Functionally, it promotes CSCC cell proliferation and inhibits apoptosis, apparently by suppressing maturation of miR-218 and reducing mature miR-218 levels. The authors propose circ-ATAD1 as a potential anti-CSCC therapeutic target."	0.5988
34255218	Biochemical genetics	2022	Hsa_circ_0006404 and hsa_circ_0000735 Regulated Ovarian Cancer Response to Docetaxel Treatment via Regulating p-GP Expression.	hsa_circ_0006404	circRNA_0006404 	hsa_circ_FOXO3	FOXO3	ovarian cancer 	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR	"hsa_circ_0006404 is down-regulated in DTX-resistant SKOV3-R ovarian cancer cells. The study supports a hsa_circ_0006404/miR-346/DKK3/p-GP axis in which hsa_circ_0006404 inhibits p-GP-associated docetaxel resistance, suppresses proliferation and tumor growth, and promotes apoptosis under DTX treatment."	0.5607
34255218	Biochemical genetics	2022	Hsa_circ_0006404 and hsa_circ_0000735 Regulated Ovarian Cancer Response to Docetaxel Treatment via Regulating p-GP Expression.	hsa_circ_0000735	circRNA_0000735 			ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"hsa_circ_0000735 is up-regulated in DTX-resistant SKOV3-R ovarian cancer cells. The study supports a hsa_circ_0000735/miR-526b or miR-546b/DKK4/p-GP axis in which hsa_circ_0000735 promotes p-GP-associated docetaxel resistance, proliferation and tumor growth while reducing apoptosis."	0.5607
34263675	Autoimmunity	2021	Circular RNA circZNF652 is overexpressed in osteoarthritis and positively regulates LPS-induced apoptosis of chondrocytes by upregulating PTEN.		circZNF652	hsa_circ_ZNF652	ZNF652	osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circZNF652 is overexpressed in synovial fluid from osteoarthritis patients and is induced by LPS in OA chondrocytes. Functionally, circZNF652 promotes LPS-induced chondrocyte apoptosis and may accelerate OA progression by upregulating PTEN and affecting MMP-13 and NF-KB expression. The study suggests circZNF652 silencing as a potential therapeutic strategy for OA."	0.5358
34265366	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association	2021	Rno_circRNA_016194 might be involved in the testicular injury induced by long-term formaldehyde exposure via rno-miR-449a-5p mediated Atg4b activation.		Rno_circRNA_016194 	rno_circ_Hyou1	Hyou1	testicular injury induced by long-term formaldehyde exposure 	MONDO:0006882	orchitis	up-regulated	RT-qPCR; Microarray	"This study identifies rno_circRNA_016194 as an up-regulated circRNA in rat testis after long-term formaldehyde exposure. The authors propose that rno_circRNA_016194 promotes formaldehyde-induced testicular injury by sponging rno-miR-449a-5p and increasing Atg4b expression, thereby enhancing autophagy-related damage; knockdown of rno_circRNA_016194 partially reverses downstream molecular changes and testicular structural injury."	0.5008
34274607	Acta histochemica	2021	Circular RNA EGLN3 silencing represses renal cell carcinoma progression through the miR-1224-3p/HMGXB3 axis.	hsa_circ_0031594	circ-EGLN3 	hsa_circ_EGLN3	EGLN3	Renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR	"Circ-EGLN3/hsa_circ_0031594 is upregulated in RCC tissues and cell lines and high expression is associated with worse overall survival. Functionally, circ-EGLN3 promotes RCC cell proliferation, migration, and invasion. Mechanistically, it acts as a miR-1224-3p sponge to indirectly upregulate HMGXB3, forming a circ-EGLN3/miR-1224-3p/HMGXB3 regulatory axis."	0.8001
34280323	Acta odontologica Scandinavica	2022	circYap inhibits oral squamous cell carcinoma by arresting cell cycle.		circYap 	hsa_circ_YAP		oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR	"circYap is downregulated in OSCC tissues and cell lines, and low expression is associated with advanced clinicopathological features and decreased overall survival. Functionally, circYap suppresses OSCC cell proliferation and arrests G1/S cell-cycle progression. Mechanistically, circYap binds CDK4, inhibits Cyclin D1/CDK4 complex formation and nuclear translocation, and thereby represses cell-cycle progression."	0.8369
34288814	"Cell cycle (Georgetown, Tex.)"	2021	"Circular RNA MAT2B promotes migration, invasion and epithelial-mesenchymal transition of non-small cell lung cancer cells by sponging miR-431."		Circular RNA MAT2B 	hsa_circ_MAT2B	MAT2B	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circMAT2B is up-regulated in NSCLC tissues and cell lines and high expression is associated with larger tumor size, advanced TNM stage and poor overall survival. Functionally, circMAT2B promotes NSCLC cell proliferation, migration, invasion and EMT. Mechanistically, it acts as a cytoplasmic ceRNA by sponging miR-431 and influencing the miR-431/ZEB1 EMT-related axis."	0.7548
34288821	"Cell cycle (Georgetown, Tex.)"	2021	"Circular RNA circSETD3 hampers cell growth, migration, and stem cell properties in bladder cancer through sponging miR-641 to upregulate PTEN."		circSETD3 	hsa_circ_SETD3	SETD3	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR	"circSETD3 is down-regulated in bladder cancer tissues and cell lines, and higher circSETD3 expression is associated with better patient survival. Functionally, circSETD3 suppresses BLCA cell growth, migration, invasion, EMT, stemness maintenance, and xenograft tumor growth. Mechanistically, it acts as a cytoplasmic ceRNA sponge for miR-641 to increase PTEN expression."	0.8439
34294360	Journal of pharmacological sciences	2021	"circ_0101802 functions as a sponge of miR-1236-3p to facilitate the proliferation, migration and invasion of colorectal cancer via regulating MACC1."	hsa_circ_0101802	circ_0101802	hsa_circ_PNN	PNN	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0101802 is up-regulated in colorectal cancer tissues and cells, and high expression is associated with poor overall survival and adverse clinicopathological features. Functionally, circ_0101802 promotes CRC proliferation, migration, invasion, EMT and xenograft tumor growth. Mechanistically, it sponges miR-1236-3p to positively regulate MACC1 expression through a ceRNA axis."	0.7859
34294845	Oncogene	2021	Hypoxic exosomal HIF-1alpha-stabilizing circZNF91 promotes chemoresistance of normoxic pancreatic cancer cells via enhancing glycolysis.		circZNF91	hsa_circ_ZNF91	ZNF91	pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; Microarray	"In pancreatic cancer, hypoxia increases circZNF91 loading into exosomes, which transmit chemoresistance to normoxic cancer cells. circZNF91 sponges miR-23b-3p to release SIRT1, stabilizing HIF-1alpha through deacetylation and enhancing glycolysis-driven gemcitabine resistance. Clinically, circZNF91 is upregulated in PC tissues and high expression predicts shorter overall survival."	0.8921
34296378	Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association	2022	CircTMC5 promotes gastric cancer progression and metastasis by targeting miR-361-3p/RABL6.	hsa_circ_0038320	circTMC5	hsa_circ_TMC5	TMC5	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circTMC5 is up-regulated in gastric cancer tissues, plasma and cell lines and predicts poorer survival. It promotes GC progression and metastasis by sponging miR-361-3p and increasing RABL6 expression, enhancing proliferation, migration and invasion while suppressing apoptosis. circTMC5 also has potential diagnostic and prognostic value, and its downstream RABL6-related effects may involve immune regulation."	0.8525
34313883	Biochemical genetics	2022	Circular RNA circ_0001017 Sensitizes Cisplatin-Resistant Gastric Cancer Cells to Chemotherapy by the miR-543/PHLPP2 Axis.	hsa_circ_0001017	circ_0001017	hsa_circ_XPO1	XPO1	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"circ_0001017 is downregulated in cisplatin-resistant gastric cancer tissues and cell lines. Its enforced expression suppresses malignant phenotypes and EMT, promotes apoptosis, and increases cisplatin sensitivity by sponging miR-543 and upregulating PHLPP2, supporting its potential therapeutic relevance in CDDP-resistant GC."	0.7597
34320692	Molecular carcinogenesis	2021	"Benzo[a]pyrene diol epoxide-induced transformed cells identify the significance of hsa_circ_0051488, a ERCC1-derived circular RNA in pulmonary squamous cell carcinoma."	hsa_circ_0051488	hsa_-circ_0051488 	hsa_circ_ERCC1	ERCC1	lung squamous cell carcinoma 	MONDO:0005097	squamous cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0051488 is an ERCC1-derived circRNA that is down-regulated in LUSC tissues and during BPDE-induced malignant transformation. It mainly localizes in the cytoplasm and suppresses LUSC-related malignant phenotypes by acting as a ceRNA sponge for miR-6717-5p, thereby regulating SATB2. Clinically, low hsa_circ_0051488 expression is associated with larger tumor diameter, lymphatic metastasis, and advanced TNM stage."	0.7799
34322757	Biochemical genetics	2022	Circ_0007031 Silencing Inhibits Cell Proliferation and Induces Cell Apoptosis via Downregulating MELK at a miR-485-3p-Dependent Way in Colorectal Cancer.	hsa_circ_0007031	circ_0007031	hsa_circ_TUBGCP3	TUBGCP3	Colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0007031 is up-regulated in colorectal cancer tissues and CRC cell lines. It promotes CRC malignant progression by sponging miR-485-3p to increase MELK expression, thereby enhancing proliferation and tumor formation while suppressing apoptosis. Its knockdown inhibits tumor growth in vivo, supporting circ_0007031 as a potential therapeutic target for CRC."	0.742
34323000	Environmental toxicology	2021	circZFR regulates thyroid cancer progression by the miR-16/MAPK1 axis.	hsa_circ_0072088	Circular RNA ZFR 	hsa_circ_ZFR	ZFR	thyroid cancer 	MONDO:0002108	thyroid cancer	up-regulated	RT-qPCR; Microarray	"circZFR is up-regulated in thyroid cancer tissues and cells and acts as an oncogenic circRNA. Silencing circZFR suppresses TC cell viability and invasion and promotes apoptosis. Mechanistically, circZFR sponges miR-16 to positively regulate MAPK1 expression, forming a circZFR/miR-16/MAPK1 axis that may represent a therapeutic target."	0.657
34324029	Archives of gynecology and obstetrics	2022	Circ_0008673 regulates breast cancer malignancy by miR-153-3p/CFL2 axis.	hsa_circ_0008673	Circ_0008673			breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0008673 is up-regulated in breast cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation, migration, invasion, EMT-like marker changes and in vivo tumor growth while inhibiting apoptosis, mainly through sponging miR-153-3p to increase CFL2 expression. The authors propose circ_0008673 as a potential predictive biomarker or therapeutic target for breast cancer."	0.7799
34325257	Chemosphere	2022	The circular RNA circTXNRD1 promoted ambient particulate matter-induced inflammation in human bronchial epithelial cells by regulating miR-892a/COX-2 axis.		circTXNRD1 	hsa_circ_TXNRD1	TXNRD1	PM-induced airway inflammation 	MONDO:0043905	pneumonitis	up-regulated	RT-qPCR; Microarray	"circTXNRD1 is a human TXNRD1-derived circular RNA that is upregulated in PM-exposed HBECs. It promotes PM-induced inflammatory responses by sponging miR-892a, increasing COX-2 expression, and enhancing IL-6 secretion, suggesting potential therapeutic relevance for PM-induced airway damage."	0.7898
34325604	Immunological investigations	2022	Circ_0003972 Promotes the Proliferation and Inflammation of Fibroblast-like Synovial Cells in Rheumatoid Arthritis through Regulation of the miR-654-5p/FZD4 Axis.	hsa_circ_0003972	circ_0003972	hsa_circ_FAM120A	FAM120A	rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"circ_0003972 is up-regulated in synovial tissues from RA patients and in HFLS-RA cells. Functionally, it promotes proliferation, cell-cycle progression and inflammatory cytokine production while suppressing apoptosis in TNFalpha-induced HFLS-RA cells. Mechanistically, circ_0003972 sponges miR-654-5p to positively regulate FZD4, suggesting a potential therapeutic role in RA."	0.7799
34326457	Laboratory investigation; a journal of technical methods and pathology	2022	CircN4BP2L2 promotes colorectal cancer growth and metastasis through regulation of the miR-340-5p/CXCR4 axis.	hsa_circ_0000471	circN4BP2L2 	hsa_circ_N4BP2L2	N4BP2L2	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circN4BP2L2/hsa_circ_0000471 is upregulated in colorectal cancer tissues and cell lines and correlates with advanced tumor stage and lymph node metastasis. Functionally, it promotes CRC proliferation, migration, invasion, tumor growth and lung metastasis while inhibiting apoptosis. Mechanistically, circN4BP2L2 acts as a ceRNA sponge for miR-340-5p to increase CXCR4 expression, supporting its potential as a CRC biomarker and therapeutic target."	0.7184
34346032	Human cell	2021	"Emerging roles of circUBAP2 targeting miR-370-3p in proliferation, apoptosis, and invasion of papillary thyroid cancer cells."	hsa_circ_0003141	circUBAP2 	hsa_circ_UBAP2	UBAP2	thyroid cancer 	MONDO:0002108	thyroid cancer	up-regulated	RT-qPCR; Microarray	"circUBAP2/hsa_circ_0003141 is upregulated in thyroid cancer and papillary thyroid cancer tissues and cell lines. It functions as an oncogenic circRNA by sponging miR-370-3p, thereby promoting TC cell proliferation and invasion while suppressing apoptosis. Clinically, circUBAP2 expression was associated with lymph node metastasis and may serve as a therapeutic target."	0.8267
34349347	Cytotechnology	2021	Blocking circ_0014130 suppressed drug resistance and malignant behaviors of docetaxel resistance-acquired NSCLC cells via regulating miR-545-3p-YAP1 axis.	hsa_circ_0014130	circ_0014130 	hsa_circ_PIP5K1A	PIP5K1A	non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0014130/circ_0014130 is upregulated in NSCLC tumors and docetaxel-resistant NSCLC cells. Its knockdown decreases docetaxel resistance, colony formation, migration, invasion, and xenograft tumor growth while increasing apoptosis. Mechanistically, circ_0014130 functions as a ceRNA for miR-545-3p to regulate YAP1 expression, suggesting a potential therapeutic target for docetaxel-resistant NSCLC."	0.7595
34357490	Journal of neuro-oncology	2021	Circ_CLIP2 promotes glioma progression through targeting the miR-195-5p/HMGB3 axis.		Circ_CLIP2 	hsa_circ_CLIP2	CLIP2	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR	"Circ_CLIP2 is up-regulated in glioma tissues and cell lines. It promotes glioma progression by sponging miR-195-5p, increasing HMGB3 expression, and activating Wnt/beta-catenin signaling, thereby enhancing proliferation and suppressing apoptosis. Clinically, increased Circ_CLIP2 expression correlates with WHO grade and KPS score."	0.6829
34363030	Cellular & molecular immunology	2021	The circular RNA circINPP4B acts as a sponge of miR-30a to regulate Th17 cell differentiation during progression of experimental autoimmune encephalomyelitis.		circINPP4B 	hsa_circ_INPP4B	INPP4B	experimental autoimmune encephalomyelitis 	MONDO:0005134	experimental autoimmune encephalomyelitis	up-regulated	RT-qPCR; ISH; Microarray	"circINPP4B is an EAE/MS progression-associated circRNA upregulated in Th17 cells during EAE progression, Th17 differentiation, and relapse-stage RRMS. It promotes Th17 differentiation and EAE severity by sponging miR-30a and relieving miR-30a-mediated inhibition of IL-21R. Silencing circINPP4B reduces Th17-associated cytokines, inflammatory infiltration and demyelination, suggesting diagnostic and therapeutic potential in Th17-mediated MS."	0.8487
34363030	Cellular & molecular immunology	2021	The circular RNA circINPP4B acts as a sponge of miR-30a to regulate Th17 cell differentiation during progression of experimental autoimmune encephalomyelitis.		circINPP4B 	mmu_circ_INPP4B	INPP4B	experimental autoimmune encephalomyelitis 	MONDO:0005134	experimental autoimmune encephalomyelitis	up-regulated	RT-qPCR; ISH; Microarray	"circINPP4B is an EAE/MS progression-associated circRNA upregulated in Th17 cells during EAE progression, Th17 differentiation, and relapse-stage RRMS. It promotes Th17 differentiation and EAE severity by sponging miR-30a and relieving miR-30a-mediated inhibition of IL-21R. Silencing circINPP4B reduces Th17-associated cytokines, inflammatory infiltration and demyelination, suggesting diagnostic and therapeutic potential in Th17-mediated MS."	0.8487
34365033	Molecular therapy : the journal of the American Society of Gene Therapy	2021	An antisense circular RNA circSCRIB enhances cancer progression by suppressing parental gene splicing and translation.	hsa_circ_0001831	circSCRIB 	hsa_circ_SCRIB	SCRIB	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"The study identifies circSCRIB/hsa_circ_0001831 as an antisense SCRIB-derived circRNA up-regulated in breast cancer specimens and cell lines. Functionally, circSCRIB suppresses parental SCRIB transcript maturation and protein expression through antisense interactions with SCRIB pre-mRNA/mRNA, thereby promoting breast cancer cell proliferation, survival, migration and invasion. Clinically, its elevated expression inversely correlates with SCRIB mRNA levels in patient specimens."	0.722
34368980	Drug development research	2022	CircTHBS1 facilitates the progression of interstitial cystitis depending on the regulation of miR-139-5p/MFN2 axis.		circTHBS1	hsa_circ_THBS1		interstitial cystitis 	MONDO:0018301	interstitial cystitis	up-regulated	RT-qPCR	"This study reports that circTHBS1 is up-regulated in IC tissues and primary IC cells and positively correlates with inflammatory cytokines in IC patients. Functionally, circTHBS1 promotes IC cell proliferation, migration, EMT, and inflammation by sponging miR-139-5p and up-regulating MFN2, suggesting potential therapeutic relevance in interstitial cystitis."	0.7289
34369049	Cell biology international	2021	"Knockdown circ_0040414 inhibits inflammation, apoptosis and promotes the proliferation of cardiomyocytes via miR-186-5p/PTEN/AKT axis in chronic heart failure."	hsa_circ_0040414	circ_0040414			heart failure 	MONDO:0005252	heart failure	up-regulated	RT-qPCR	"circ_0040414 is up-regulated in peripheral blood from patients with chronic heart failure and shows diagnostic potential. Functionally, circ_0040414 promotes cardiomyocyte apoptosis and inflammation while inhibiting proliferation. Mechanistically, it sponges miR-186-5p to increase PTEN and suppress AKT signaling activity."	0.8162
34370061	Mammalian genome : official journal of the International Mammalian Genome Society	2021	CircRNA_0043691 sponges miR-873-3p to promote metastasis of gastric cancer.	hsa_circ_0043691	circRNA_0043691 			gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circRNA_0043691 is upregulated in gastric cancer tissues and functions as an oncogenic circRNA. It promotes GC cell proliferation, migration, invasion, and metastasis by sponging miR-873-3p and upregulating GART expression, and its knockdown is proposed as a potential therapeutic strategy."	0.6479
34375168	"Cell cycle (Georgetown, Tex.)"	2021	CircTYW1 serves as a sponge for microRNA-380 in accelerating neurological recovery following spinal cord injury via regulating FGF9.	hsa_circ_0003962		hsa_circ_TYW1	TYW1	spinal cord injury 	MONDO:0043797	spinal cord injury	down-regulated	RT-qPCR; Microarray	"circTYW1 is down-regulated in spinal cord tissues of SCI rats and in OGD-treated PC12 cells. Functionally, circTYW1 overexpression promotes neurological recovery and neuronal survival while suppressing apoptosis and cytotoxic injury. Mechanistically, circTYW1 functions as a miR-380 sponge to increase FGF9 expression and activate ERK1/2 signaling."	0.7933
34375168	"Cell cycle (Georgetown, Tex.)"	2021	CircTYW1 serves as a sponge for microRNA-380 in accelerating neurological recovery following spinal cord injury via regulating FGF9.			rno_circ_TYW1	TYW1	spinal cord injury 	MONDO:0043797	spinal cord injury	down-regulated	RT-qPCR; Microarray	"circTYW1 is down-regulated in spinal cord tissues of SCI rats and in OGD-treated PC12 cells. Functionally, circTYW1 overexpression promotes neurological recovery and neuronal survival while suppressing apoptosis and cytotoxic injury. Mechanistically, circTYW1 functions as a miR-380 sponge to increase FGF9 expression and activate ERK1/2 signaling."	0.7933
34378131	Environmental science and pollution research international	2022	Sodium arsenite-mediated upregulation of circDHX34 promotes apoptosis in hormone-independent breast cancer cells by regulating apoptotic genes.		circDHX34 	hsa_circ_DHX34	DHX34	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"In sodium arsenite-treated hormone-independent breast cancer MDA-MB-231 cells, circDHX34 is up-regulated in a dose-dependent manner. Functional knockdown experiments indicate that circDHX34 suppresses proliferation and promotes apoptosis, likely through regulation of apoptotic genes including BCL2, BCL2L1, CASP8 and CASP9."	0.3513
34406448	Mammalian genome : official journal of the International Mammalian Genome Society	2021	CircRNA circ-ATAD1 is downregulated in endometrial cancer and suppresses cell invasion and migration by downregulating miR-10a through methylation.		circ-ATAD1	hsa_circ_ATAD1	ATAD1	endometrial cancer 	MONDO:0011962	endometrial cancer	down-regulated	RT-qPCR; Microarray	"circ-ATAD1 was reported to be downregulated in endometrial cancer tissues. In EC cells, circ-ATAD1 overexpression decreased miR-10a expression, increased miR-10a gene methylation, and suppressed invasion and migration, suggesting a potential anti-metastatic role."	0.6166
34409524	Biochemical genetics	2022	Circ-DONSON Facilitates the Malignant Progression of Gastric Cancer Depending on the Regulation of miR-149-5p/LDHA Axis.	hsa_circ_0004339	circ-DONSON	hsa_circ_DONSON	DONSON	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ-DONSON is up-regulated in gastric cancer tissues and cell lines. It promotes malignant GC progression by enhancing proliferation, migration, invasion, angiogenesis, tumor growth and radioresistance while inhibiting apoptosis. Mechanistically, circ-DONSON sponges miR-149-5p to upregulate LDHA through the circ-DONSON/miR-149-5p/LDHA axis."	0.7132
34409897	Autoimmunity	2021	A novel circ_0099999/miR-330-5p/FSCN1 ceRNA crosstalk in pancreatic cancer.	hsa_circ_0099999	circ_0099999	hsa_circ_ZMYM2	ZMYM2	pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"circ_0099999 is up-regulated in pancreatic cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation, colony formation, migration, invasion, glycolysis, and xenograft tumour growth while suppressing apoptosis. Mechanistically, cytoplasmic circ_0099999 acts as a ceRNA for miR-330-5p to increase FSCN1 expression, suggesting that circ_0099999 inhibition may have therapeutic value in pancreatic cancer."	0.7859
34423389	Inflammation	2021	Paeoniflorin Suppresses Rheumatoid Arthritis Development via Modulating the Circ-FAM120A/miR-671-5p/MDM4 Axis.	hsa_circ_0003972	circ-FAM120A	hsa_circ_FAM120A	FAM120A	rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"circ-FAM120A is up-regulated in RA synovial tissues and RA-FLSs and promotes RA-FLS proliferation, migration, invasion, and inflammatory cytokine production. Mechanistically, it acts as a miR-671-5p decoy to regulate MDM4, forming the circ-FAM120A/miR-671-5p/MDM4 axis through which paeoniflorin suppresses RA-FLS progression."	0.7416
34424459	Digestive diseases and sciences	2022	Hsa_circ_0001020 Serves as a Potential Biomarker for Gastric Cancer Screening and Prognosis.	hsa_circ_0001020		hsa_circ_UGP2	UGP2	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"Hsa_circ_0001020 is upregulated in gastric cancer cell lines, tissues, and plasma and is associated with distal metastasis and CA19-9. Its high expression predicts poorer overall and disease-free survival, and plasma hsa_circ_0001020 shows diagnostic/screening value, especially in combination with conventional tumor biomarkers. Bioinformatics analysis suggests a predicted hsa_circ_0001020-miRNA-target/pathway mechanism involving hsa-miR-19a-3p, hsa-miR-103a-2-5p, and cancer-related pathways such as p53 and FoxO signaling."	0.6759
34431434	Autoimmunity	2021	"Circ-Sirt1 inhibits proliferation, induces apoptosis, and ameliorates inflammation in human rheumatoid arthritis fibroblast-like synoviocytes."		Circular RNA Sirt1 	hsa_circ_Sirt1	Sirt1	Rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	down-regulated	RT-qPCR	"circ-Sirt1 is down-regulated in RA-FLS MH7A cells compared with normal FLS. Its overexpression suppresses MH7A proliferation, promotes apoptosis, reduces IL-1b, IL-6, TNF-a, MMP-1 and MMP-3, and ameliorates inflammation through a miR-132/Sirt1-related mechanism involving inhibition of NF-jB signaling and activation of Nrf2/HO-1 signaling. The study proposes circ-Sirt1 as a potential therapeutic target for RA."	0.6441
34435328	Molecular neurobiology	2021	Circular RNA 0025984 Ameliorates Ischemic Stroke Injury and Protects Astrocytes Through miR-143-3p/TET1/ORP150 Pathway.	hsa_circ_0025984				ischemic stroke 	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR	"circ_0025984 is down-regulated in OGD-treated astrocytes and MCAO brain tissues. Its overexpression protects astrocytes and alleviates ischemic brain injury by sponging miR-143-3p, increasing TET1, inducing ORP150 expression via promoter demethylation, and suppressing autophagy and apoptosis-related programs."	0.7027
34453920	Analytical biochemistry	2021	Propofol suppresses colorectal cancer development by the circ-PABPN1/miR-638/SRSF1 axis.	hsa_circ_0031288	circRNA poly(A) binding protein nuclear 1 	hsa_circ_PABPN1	PABPN1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"Circ-PABPN1 is up-regulated in CRC tissues and cells and functions as a pro-tumor circRNA. Propofol suppresses CRC development partly by down-regulating circ-PABPN1, which releases miR-638 activity and reduces SRSF1 expression, leading to decreased growth, invasion, migration, metastasis and increased apoptosis."	0.7183
34460046	Metabolic brain disease	2021	Sevoflurane impedes glioma progression via regulating circ_0000215/miR-1200/NCR3LG1 axis.	hsa_circ_0000215	circ_0000215			glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ_0000215 is up-regulated in glioma cells and is decreased by sevoflurane treatment. Functionally, circ_0000215 overexpression counteracts sevoflurane-mediated suppression of glioma proliferation, migration, invasion and xenograft growth, while reducing apoptosis. Mechanistically, circ_0000215 sponges miR-1200 to increase NCR3LG1 expression, forming a circ_0000215/miR-1200/NCR3LG1 regulatory axis."	0.705
34462830	Inflammation	2022	"Circular RNA circ_0008360 Inhibits the Proliferation, Migration, and Inflammation and Promotes Apoptosis of Fibroblast-Like Synoviocytes by Regulating miR-135b-5p/HDAC4 Axis in Rheumatoid Arthritis."	hsa_circ_0008360	circ_0008360	hsa_circ_XPNPEP3	XPNPEP3	rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	down-regulated	RT-qPCR	"Circ_0008360 is downregulated in RA synovial tissues and RA-FLSs. Functionally, it suppresses RA-FLS proliferation, migration and inflammatory cytokine production while promoting apoptosis. Mechanistically, circ_0008360 sponges miR-135b-5p to upregulate HDAC4, suggesting a protective role and potential therapeutic relevance in RA."	0.8275
34463003	Journal of biochemical and molecular toxicology	2021	EIF4A3-mediated hsa_circ_0088088 promotes the carcinogenesis of breast cancer by sponging miR-135-5p.	hsa_circ_0088088		hsa_circ_HSDL2	HSDL2	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"hsa_circ_0088088 is up-regulated in breast cancer tissues and cell lines, and high expression predicts poor overall survival. Functionally, it promotes breast cancer cell growth, proliferation, migration, invasion and metastasis while suppressing apoptosis. Mechanistically, EIF4A3 positively regulates hsa_circ_0088088 biogenesis/expression, and hsa_circ_0088088 promotes carcinogenesis by sponging miR-135-5p."	0.7962
34463892	Functional & integrative genomics	2021	Pepsinogen C expression-related lncRNA/circRNA/mRNA profile and its co-mediated ceRNA network in gastric cancer.	hsa_circ_0008197				gastric cancer	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0008197 was identified as a PGC expression-related circRNA in gastric cancer and was validated by qRT-PCR as downregulated in gastric cancer tissues. The study proposes that hsa_circ_0008197, together with SNHG16, participates in a ceRNA axis involving hsa-mir-98-5p, hsa-let-7f-5p, hsa-let-7c-5p, and PGC, potentially modulating PGC expression and gastric cancer progression."	0.62
34468993	Annals of the New York Academy of Sciences	2022	Circ-E2F3 promotes cervical cancer progression by inhibiting microRNA-296-5p and increasing STAT3 nuclear translocation.		circ-E2F3 	hsa_circ_E2F3	E2F3	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Northern Blot	"circ-E2F3 is upregulated in cervical cancer tissues and cell lines and is associated with aggressive clinicopathological features and poor prognosis. Functionally, circ-E2F3 promotes cervical cancer proliferation, migration, invasion, tumor growth, metastasis, and angiogenesis. Mechanistically, circ-E2F3 inhibits miR-296-5p to activate STAT3 nuclear translocation and increase cyclin D1 expression."	0.7989
34469009	Andrologia	2021	CircRNA pappalysin 1 facilitates prostate cancer development through miR-515-5p/FKBP1A axis.	hsa_circ_0088233		hsa_circ_PAPPA	PAPPA	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"Circ-PAPPA (hsa_circ_0088233) is up-regulated in prostate cancer tissues and cell lines. It promotes malignant phenotypes including proliferation, migration, invasion, glycolysis and xenograft tumour growth while suppressing apoptosis, mainly through sponging miR-515-5p to increase FKBP1A expression. Higher circ-PAPPA expression is associated with aggressive clinicopathological features such as higher Gleason score, lymph node metastasis and advanced clinical T stage."	0.8006
34470585	"Cell cycle (Georgetown, Tex.)"	2021	Hsa_circ_0060937 accelerates non-small cell lung cancer progression via modulating miR-195-5p/HMGB3 pathway.	hsa_circ_0060937	circ_0060937 	hsa_circ_CYP24A1	CYP24A1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ_0060937 is up-regulated in NSCLC tissues and cells, and high expression is associated with poor overall survival. Functionally, circ_0060937 promotes NSCLC proliferation, migration, invasion, glycolysis and in vivo tumor growth while suppressing apoptosis. Mechanistically, cytoplasmic circ_0060937 sponges miR-195-5p to increase HMGB3 expression."	0.8571
34471233	Cancer gene therapy	2023	circPTPN22 attenuates immune microenvironment of pancreatic cancer via STAT3 acetylation.	hsa_circ_0000110	circPTPN22	hsa_circ_PTPN22	PTPN22	pancreatic cancer	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; ISH	"circPTPN22 is up-regulated in pancreatic cancer tissues and cell lines. Functionally, it promotes pancreatic cancer cell proliferation and tumor growth while weakening antitumor immune infiltration. Mechanistically, circPTPN22 interacts with STAT3 and promotes STAT3 acetylation by inhibiting the STAT3/SIRT1 interaction."	0.8397
34471941	Biochemical genetics	2022	Circular RNA circMMP1 Contributes to the Progression of Glioma Through Regulating TGIF2 Expression by Sponging miR-195-5p.	hsa_circ_0024108		hsa_circ_MMP1	MMP1	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circMMP1 is upregulated in glioma tissues and A172/U251 glioma cells. It promotes glioma progression by acting as a ceRNA sponge for miR-195-5p, relieving repression of TGIF2 expression, thereby enhancing colony formation, migration, invasion, and tumor growth while suppressing apoptosis and autophagy."	0.7795
34477035	Immunopharmacology and immunotoxicology	2021	Hsa-circ_0003420 induces apoptosis in acute myeloid leukemia stem cells and impairs stem cell properties.	hsa_circ_0003420				acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	down-regulated	RT-qPCR	"hsa-circ_0003420 is down-regulated in AML LSCs, especially in patients with poor prognosis, and higher expression is associated with better therapeutic effects. Functionally, hsa-circ_0003420 overexpression suppresses leukemia cell tumorigenesis, viability, replication, and LSC phenotype while inducing apoptosis. Mechanistically, it negatively regulates IGF2BP1 by targeting its 3'-UTR, reducing downstream LSC-related factors such as HOXB4, MYB, and ALDH1A1."	0.6542
34478121	"Reproductive sciences (Thousand Oaks, Calif.)"	2021	CircRNA circFADS2 is Downregulated in Endometritis and its Overexpression Promotes miR-643 Maturation in Human Endometrial Epithelial Cells to Suppress Cell Apoptosis.			hsa_circ_FADS2	FADS2	endometritis	MONDO:0000918	endometritis	down-regulated	RT-qPCR	"circFADS2 is significantly downregulated in plasma from endometritis patients and is positively correlated with mature miR-643. Functional experiments in HEnEpCs indicate that circFADS2 overexpression promotes miR-643 maturation and suppresses LPS-induced apoptosis, suggesting a protective role in endometritis."	0.4862
34480353	Annals of the New York Academy of Sciences	2021	CircRNA_103948 inhibits autophagy in colorectal cancer in a ceRNA manner.		circRNA_103948 	hsa_circ_SEC24A	SEC24A	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; Microarray	"circRNA_103948 is upregulated in colorectal cancer tissues and cell lines and predicts poor prognosis. Functionally, it promotes CRC proliferation, migration, invasion, metastasis and xenograft tumor growth while inhibiting autophagy. Mechanistically, circRNA_103948 acts as a miR-1236-3p sponge to relieve repression of TPT1, thereby modulating TPT1-mediated autophagy and CRC progression."	0.8647
34494941	"Cell cycle (Georgetown, Tex.)"	2021	Circ-PGC increases the expression of FOXR2 by targeting miR-532-3p to promote the development of non-small cell lung cancer.	hsa_circ_0076305		hsa_circ_PGC	PGC	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"Circ-PGC is up-regulated in NSCLC tissues and cell lines and high expression is associated with poor overall survival. Functionally, circ-PGC promotes NSCLC cell proliferation, migration, invasion, glycolysis and in vivo tumor growth, while suppressing apoptosis. Mechanistically, circ-PGC sponges miR-532-3p to increase FOXR2 expression and may activate Wnt/beta-catenin signaling."	0.8175
34495821	Brain injury	2021	Circ_0062166 aggravates cerebral ischemia-reperfusion injury through targeting miR-526b-5p/BCL2L13 axis.	mmu_circ_0062166	circ_0062166 	mmu_circ_BCL2L13	BCL2L13	Cerebral ischemia-reperfusion injury 	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR	"In an OGD/R model of cerebral ischemia-reperfusion injury using mouse N2A cells, circ_0062166/circ_BCL2L13 was up-regulated. The study shows that circ_0062166 promotes CIR injury-related cell proliferation and suppresses apoptosis by acting as a ceRNA for miR-526b-5p and increasing BCL2L13 expression. The authors propose circ_0062166 as a potential biomarker and therapeutic target for CIR injury."	0.8058
34499003	Autoimmunity	2021	Circ-UQCRC2 aggravates lipopolysaccharide-induced injury in human bronchial epithelioid cells via targeting miR-495-3p/MYD88-mediated inflammatory response and oxidative stress.	hsa_circ_0038467	circ-UQCRC2 	hsa_circ_UQCRC2	UQCRC2	infantile pneumonia 	MONDO:0005249	pneumonia	up-regulated	RT-qPCR	"Circ-UQCRC2 is up-regulated in LPS-induced 16HBE pneumonia cell models and aggravates cell injury. Mechanistically, circ-UQCRC2 sponges miR-495-3p to increase MYD88 expression and promote NF-kappaB-associated inflammatory response, apoptosis, and oxidative stress. Silencing circ-UQCRC2 protects 16HBE cells from LPS-mediated damage, suggesting potential therapeutic relevance in infantile pneumonia."	0.7615
34504314	Cell death and differentiation	2022	Circular RNA Cwc27 contributes to Alzheimer's disease pathogenesis by repressing Pur-alpha activity.	mmu_circ_0004423	circCwc27 	mmu_circ_Cwc27	Cwc27	Alzheimer's disease 	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR; ISH; RNA-seq	"circCwc27 is an abundant neuron-enriched circRNA that is up-regulated in APP/PS1 mouse brains and in temporal cortex and plasma from AD patients. It promotes AD-related pathology by binding Pur-alpha, retaining Pur-alpha in the cytoplasm, and reducing Pur-alpha-mediated transcriptional regulation of AD-related genes; circCwc27 knockdown improves cognitive deficits, lowers Abeta deposition, and reduces neuroinflammatory/neurodegenerative effects."	0.8638
34511010	Experimental lung research	2021	Identification of circular RNA circVPS33A as a modulator in house dust mite-induced injury in human bronchial epithelial cells.	hsa_circ_0000455	circVPS33A 	hsa_circ_VPS33A	VPS33A	asthma 	MONDO:0004979	asthma	up-regulated	RT-qPCR	"circVPS33A is up-regulated in plasma from asthma patients and in Der p1-treated human bronchial epithelial BEAS-2B cells. It promotes Der p1-induced epithelial cell injury through a circVPS33A/miR-192-5p/HMGB1 regulatory axis, while circVPS33A knockdown alleviates inflammation, apoptosis, autophagy, and defects in proliferation, migration, and invasion. The authors propose circVPS33A as a potential screening biomarker and regulatory target in house dust mite-driven asthma."	0.7949
34514700	Oral diseases	2023	Hsa_circ_0009128 mediates progression of oral squamous cell carcinoma by influencing MMP9.	hsa_circ_0009128		hsa_circ_TXNDC11	TXNDC11	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0009128 is upregulated in OSCC tissues and cell lines and is associated with advanced TNM stage and lymph node metastasis. Functionally, it promotes OSCC cell proliferation and migration, and mechanistically it appears to enhance MMP9 expression and activate EMT. The study suggests hsa_circ_0009128 may serve as an oncogenic circRNA and a potential diagnostic marker or therapeutic target in OSCC."	0.7552
34515875	Digestive diseases and sciences	2022	CircTUBGCP3 Contributes to the Malignant Progression of Rectal Cancer.		circTUBGCP3 	hsa_circ_TUBGCP3	TUBGCP3	rectal cancer	MONDO:0006519	rectal cancer	up-regulated	RT-qPCR	"CircTUBGCP3 is up-regulated in rectal cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes colony formation, migration, invasion, cell cycle progression, glycolysis, and xenograft tumor growth while suppressing apoptosis, at least partly by sponging miR-375 and regulating ROCK1 expression."	0.7859
34524572	Cell biology and toxicology	2023	CircRNA_0026344 via miR-21 is involved in cigarette smoke-induced autophagy and apoptosis of alveolar epithelial cells in emphysema.		circRNA_0026344 	hsa_circ_ACVRL1		emphysema 	MONDO:0004849	pulmonary emphysema	down-regulated	RT-qPCR	"circRNA_0026344 is down-regulated in lung tissues from COPD smokers, in CS-exposed mouse lungs, and in CSE-treated alveolar epithelial cells. It functions mainly as a cytoplasmic miR-21 sponge, regulating PTEN/ERK/mTOR signaling and suppressing CSE-induced autophagy and apoptosis in alveolar epithelial cells, implicating it in cigarette smoke-induced emphysema."	0.7893
34528144	Biochemical genetics	2022	CircLPAR3 Acts as an Oncogene in Oral Squamous Cell Carcinoma Through Regulating the miR-643/HMGB2 Network.	hsa_circ_0004390	circLPAR3	hsa_circ_LPAR3	LPAR3	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circLPAR3 is up-regulated in OSCC tissues and cell lines, and high expression predicts poorer overall survival. Functionally, circLPAR3 acts as an oncogenic circRNA that promotes proliferation, migration, invasion, stemness and xenograft tumor growth while suppressing apoptosis. Mechanistically, circLPAR3 sponges miR-643 to up-regulate HMGB2, forming a circLPAR3/miR-643/HMGB2 regulatory axis."	0.8066
34532813	Molecular and cellular biochemistry	2022	Tanshinone I restrains osteosarcoma progression by regulating circ_0000376/miR-432-5p/BCL2 axis.	hsa_circ_0000376	circ_0000376			osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"circ_0000376 is up-regulated in osteosarcoma tissues and cell lines and functions as an oncogenic circRNA. Tan I suppresses OS progression partly by down-regulating circ_0000376, which otherwise sponges miR-432-5p to increase BCL2 expression and promote viability, migration, invasion, and glycolysis while inhibiting apoptosis. Silencing circ_0000376 enhances the anti-tumor effect of Tan I in a U2OS xenograft model."	0.7126
34536179	Cellular and molecular neurobiology	2022	"Circ_0007534 Silencing Inhibits the Proliferation, Migration and Invasion and Induces the Apoptosis of Glioma Cells Partly Through Down-Regulating PROX1 Via Elevating miR-22-3p Level."	hsa_circ_0007534				glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"Circ_0007534 is up-regulated in glioma tissues and cell lines and its higher level is associated with more advanced malignant grade. Functionally, circ_0007534 promotes glioma cell proliferation, migration, invasion and xenograft tumor growth while inhibiting apoptosis. Mechanistically, it acts through the miR-22-3p/PROX1 axis, consistent with a ceRNA-like oncogenic role."	0.7126
34536574	"Clinical immunology (Orlando, Fla.)"	2021	Exosome-mediated circ_0001846 participates in IL-1beta-induced chondrocyte cell damage by miR-149-5p-dependent regulation of WNT5B.	hsa_circ_0001846	circ_0001846 	hsa_circ_UBAP2	UBAP2	Osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circ_0001846 is up-regulated in osteoarthritis cartilage tissues and IL-1beta-treated CHON-001 chondrocytes, including in exosomes. Functionally, circ_0001846 promotes IL-1beta-induced chondrocyte injury by aggravating apoptosis, inflammation and ECM degradation while reducing viability, invasion and migration. Mechanistically, exosome-mediated circ_0001846 acts through the miR-149-5p/WNT5B axis, suggesting a potential therapeutic target for OA."	0.7799
34541682	Drug development research	2022	CircATL2 enhances paclitaxel resistance of ovarian cancer via impacting miR-506-3p/NFIB axis.	hsa_circ_0000993	circRNA Atlastin GTPase 2 	hsa_circ_ATL2	ATL2	ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"CircATL2 is a human ATL2-derived circRNA upregulated in PTX-resistant ovarian cancer tissues and cells. It promotes paclitaxel resistance and malignant cell behaviors by sponging miR-506-3p, thereby increasing NFIB expression; circATL2 knockdown sensitizes resistant OC cells to PTX and suppresses resistance in xenograft tumors."	0.8174
34546569	Clinical and experimental pharmacology & physiology	2022	CircSAMD11 facilitates progression of cervical cancer via regulating miR-503/SOX4 axis through Wnt/beta-catenin pathway.	hsa_circ_0009189	circSAMD11 	hsa_circ_SAMD11	SAMD11	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0009189/circSAMD11 is up-regulated in cervical cancer tissues and cells and high expression is associated with poor overall survival. Functionally, circSAMD11 promotes proliferation, migration, invasion and xenograft tumor growth while suppressing apoptosis. Mechanistically, cytoplasmic circSAMD11 sponges miR-503 to increase SOX4 expression and activate the Wnt/beta-catenin pathway."	0.8793
34555307	"Hematology (Amsterdam, Netherlands)"	2021	CircRNA circ_0001821 predicts an unfavorable prognosis and promotes the proliferation of multiple myeloma.	hsa_circ_0001821	circ_0001821			multiple myeloma	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR	"circ_0001821 is up-regulated in multiple myeloma bone marrow tissues and cell lines. High circ_0001821 expression is associated with aggressive clinicopathological indicators and poor overall survival, especially in patients aged ¡Ý60 years. Functionally, circ_0001821 promotes multiple myeloma cell proliferation and inhibits apoptosis, accompanied by reduced Caspase-3 protein expression."	0.6527
34559381	Immunologic research	2021	Circular RNA hsa_circ_0001598 promotes programmed death-ligand-1-mediated immune escape and trastuzumab resistance via sponging miR-1184 in breast cancer cells.	hsa_circ_0001598	circ_0001598			breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"hsa_circ_0001598/circ_0001598 is up-regulated in HER2-positive breast cancer and further elevated in trastuzumab-resistant samples and cell lines. It promotes breast cancer cell proliferation, trastuzumab resistance, PD-L1 expression, and immune escape by sponging miR-1184 to regulate PD-L1. High circ_0001598 expression is associated with worse overall survival, suggesting potential clinical relevance as a therapeutic target in HER2-positive breast cancer."	0.7617
34562605	Cellular signalling	2021	"Circ_0011058 facilitates proliferation, angiogenesis and radioresistance in papillary thyroid cancer cells by positively regulating YAP1 via acting as miR-335-5p sponge."	hsa_circ_0011058	circ_0011058	hsa_circ_TMEM222	TMEM222	papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circ_0011058 is up-regulated in papillary thyroid cancer tissues and cells, and high expression predicts poor overall survival. Functionally, it promotes proliferation, angiogenesis, radioresistance and in vivo tumor growth while suppressing apoptosis. Mechanistically, circ_0011058 acts as a miR-335-5p sponge to upregulate YAP1, forming a circ_0011058/miR-335-5p/YAP1 regulatory pathway."	0.849
34564768	Molecular biotechnology	2022	CircRNA Circ-CCND1 Aggravates Hepatocellular Carcinoma Tumorigenesis by Regulating the miR-497-5p/HMGA2 Axis.		Circ-CCND1	hsa_circ_CCND1	CCND1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"Circ-CCND1 is up-regulated in HCC tissues and cell lines and is associated with larger tumor size and lymph node metastasis. It mainly localizes in the cytoplasm and promotes HCC cell proliferation, migration, and invasion by sponging miR-497-5p and up-regulating HMGA2 through a ceRNA mechanism."	0.7404
34570663	"Cell cycle (Georgetown, Tex.)"	2021	Circ_0004018 suppresses cell proliferation and migration in hepatocellular carcinoma via miR-1197/PTEN/PI3K/AKT signaling pathway.	hsa_circ_0004018	circ_0004018	hsa_circ_SMYD4	SMYD4	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0004018/circ_0004018 is down-regulated in HCC cells. Its overexpression suppresses HCC cell proliferation and migration by sponging miR-1197, increasing PTEN expression, and inactivating PI3K/AKT signaling."	0.8081
34588633	Cell death and differentiation	2022	The circRNA CNEACR regulates necroptosis of cardiomyocytes through Foxa2 suppression.		mmu_circ_000338 			myocardial ischemia-reperfusion injury 	MONDO:0005203	ischemia reperfusion injury	down-regulated	RT-qPCR; Microarray	"CNEACR/mmu_circ_000338 is down-regulated in H/R-exposed cardiomyocytes and I/R-injured mouse hearts. It protects cardiomyocytes from necrotic/necroptotic death by binding cytoplasmic HDAC7, limiting HDAC7 nuclear entry, restoring Foxa2 transcription, and suppressing RIPK3/MLKL-associated necroptosis, thereby reducing infarct size and improving cardiac function."	0.7968
34606982	Annals of hepatology	2022	Circ_0078710 promotes the development of liver cancer by upregulating TXNDC5 via miR-431-5p.	hsa_circ_0078710				liver cancer 	MONDO:0002691	liver cancer	up-regulated	RT-qPCR	"Circ_0078710 is up-regulated in liver cancer tissues and HCC cell lines. It promotes malignant phenotypes including proliferation, migration, invasion, glycolytic metabolism and xenograft tumor growth while suppressing apoptosis, at least partly through the miR-431-5p/TXNDC5 axis. The study proposes circ_0078710 as a potential therapeutic target for liver cancer."	0.713
34612550	The journal of gene medicine	2022	Circular RNA ITCH attenuates the progression of nasopharyngeal carcinoma by inducing PTEN upregulation via miR-214.		Circular RNA itchy E3 ubiquitin protein ligase 	hsa_circ_ITCH	ITCH	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	down-regulated	RT-qPCR	"circ-ITCH is downregulated in nasopharyngeal carcinoma tissues and cell lines. Functionally, circ-ITCH acts as a tumor suppressor by inhibiting NPC cell proliferation, migration, invasion and xenograft tumor growth. Mechanistically, it sponges miR-214 to relieve repression of PTEN, and lower circ-ITCH expression is associated with more advanced TNM stage, clinical stage and lymphatic metastasis."	0.713
34619576	"Pathology, research and practice"	2021	The effects of hsa_circ_0000517/miR-326 axis on the progression of breast cancer cells and the prediction of miR-326 downstream targets in breast cancer.	hsa_circ_0000517	hsa_circRNA_001678 	hsa_circ_RPPH1	RPPH1	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000517 is upregulated in breast cancer tissues and cells and behaves as an oncogenic circRNA. It is stable, cytoplasm-enriched, and promotes breast cancer cell proliferation, colony formation and invasion while suppressing apoptosis, mainly by sponging miR-326 and reducing miR-326 expression. The study also predicted 17 potential miR-326 downstream targets, suggesting a hsa_circ_0000517/miR-326/mRNA regulatory axis in breast cancer progression."	0.7216
34624276	Experimental and molecular pathology	2021	CircWHSC1 regulates malignancy and glycolysis by the miR-212-5p/AKT3 pathway in triple-negative breast cancer.	hsa_circ_0001387	circWHSC1 	hsa_circ_WHSC1	WHSC1	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"CircWHSC1 is upregulated in breast cancer tissues and cells and high expression is associated with poor prognosis in TNBC. Functionally, circWHSC1 promotes TNBC malignant phenotypes, tumor growth and glycolysis while suppressing apoptosis. Mechanistically, cytoplasmic circWHSC1 sponges miR-212-5p to regulate AKT3, forming a circWHSC1/miR-212-5p/AKT3 axis with potential prognostic and therapeutic relevance."	0.807
34632534	Mammalian genome : official journal of the International Mammalian Genome Society	2021	Circ_0069718 promotes the progression of breast cancer by up-regulating NFIB through sequestering miR-590-5p.	hsa_circ_0069718	circ_0069718	hsa_circ_DCUN1D4	DCUN1D4	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"Circ_0069718 is up-regulated in breast cancer tissues and cell lines and acts as an oncogenic circRNA. It promotes malignant phenotypes and tumor growth by sponging miR-590-5p and thereby increasing NFIB expression, suggesting potential therapeutic relevance in breast cancer."	0.8439
34633608	International ophthalmology	2022	Circ_0075804 promotes the malignant behaviors of retinoblastoma cells by binding to miR-138-5p to induce PEG10 expression.	hsa_circ_0075804	circ_0075804	hsa_circ_E2F3	E2F3	retinoblastoma 	MONDO:0008380	retinoblastoma	up-regulated	RT-qPCR	"circ_0075804 is up-regulated in retinoblastoma tissues and cell lines and acts as an oncogenic circRNA. It promotes RB cell proliferation, migration, invasion and xenograft tumor growth while suppressing apoptosis. Mechanistically, cytoplasmic circ_0075804 sponges miR-138-5p to increase PEG10 expression, forming a circ_0075804/miR-138-5p/PEG10 regulatory axis with potential therapeutic relevance."	0.8443
34634673	Biochemical and biophysical research communications	2021	CircRNA CircZMYM4 inhibits the growth and metastasis of lung adenocarcinoma via the miR-587/ODAM pathway.		CircRNA zinc finger MYM-type containing 4	hsa_circ_ZMYM4	ZMYM4	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; Microarray	"circZMYM4 is a human ZMYM4-derived circRNA that is downregulated in LUAD tissues and cell lines. It suppresses LUAD proliferation, migration, invasion, metastasis and xenograft tumor growth by acting as a miR-587 sponge and upregulating ODAM expression, suggesting potential biomarker and therapeutic relevance."	0.854
34664776	Environmental toxicology	2022	"Circ-SNAP47 (hsa_circ_0016760) and miR-625-5p are regulators of WEE1 in regulation of chemoresistance, growth and invasion of DDP-tolerant NSCLC cells via ceRNA pathway."	hsa_circ_0016760	circ-SNAP47	hsa_circ_SNAP47	SNAP47	non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ-SNAP47 (hsa_circ_0016760), derived from SNAP47, is upregulated in DDP-resistant NSCLC tissues and DDP-tolerant NSCLC cells. It promotes cisplatin/DDP chemoresistance, proliferation, colony formation, invasion and xenograft tumor growth while suppressing apoptosis, mainly through a cytoplasmic ceRNA mechanism involving miR-625-5p and WEE1. Knockdown of circ-SNAP47 sensitizes DDP-tolerant NSCLC cells to DDP and may represent a potential therapeutic strategy for reversing DDP resistance."	0.786
34695392	Brain research	2022	The circRNA circ-Nbea participates in regulating diabetic encephalopathy.		circ-Nbea 	mmu_circ_Nbea	Nbea	diabetic encephalopathy 	MONDO:0000489	diabetic encephalopathy	down-regulated	RT-qPCR; RNA-seq	"circ-Nbea is a mouse circRNA derived from the Nbea gene that is downregulated in AGE-treated primary hippocampal neurons and in the hippocampus of db/db diabetic mice. The study supports a circ-Nbea/miR-128-3p mechanism, potentially affecting BDNF and contributing to diabetic encephalopathy-related learning and memory dysfunction."	0.6328
34695392	Brain research	2022	The circRNA circ-Nbea participates in regulating diabetic encephalopathy.		circ-Smox 	mmu_circ_Smox	Smox	diabetic encephalopathy 	MONDO:0000489	diabetic encephalopathy	down-regulated	RT-qPCR; RNA-seq	"circ-Smox is a mouse circRNA derived from the Smox gene. It was identified by RNA-Seq and validated by qRT-PCR as significantly downregulated in AGE-treated primary hippocampal neurons and in db/db mouse hippocampus, but the study did not investigate its specific mechanism or function."	0.4468
34695392	Brain research	2022	The circRNA circ-Nbea participates in regulating diabetic encephalopathy.		circ-Setbp1 	mmu_circ_Setbp1	Setbp1	diabetic encephalopathy 	MONDO:0000489	diabetic encephalopathy	down-regulated	RT-qPCR; RNA-seq	"circ-Setbp1 is a mouse circRNA derived from the Setbp1 gene. It was identified by RNA-Seq and validated by qRT-PCR as significantly downregulated in AGE-treated primary hippocampal neurons and in db/db mouse hippocampus, but the study did not investigate its specific mechanism or function."	0.4468
34709546	Environmental science and pollution research international	2022	CircRNA circ_0000554 promotes ovarian cancer invasion and proliferation by regulating miR-567.	hsa_circ_0000554	circ_0000554			ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circ_0000554 is up-regulated in ovarian tumor specimens and ovarian tumor cell lines. Functionally, circ_0000554 promotes ovarian tumor cell proliferation, invasion, cell cycle-associated marker expression, and EMT. Mechanistically, it acts through sponging miR-567, suggesting potential therapeutic relevance in ovarian tumor."	0.6903
34709725	International journal of laboratory hematology	2022	Circ_0009910 sponges miR-491-5p to promote acute myeloid leukemia progression through modulating B4GALT5 expression and PI3K/AKT signaling pathway.	hsa_circ_0009910	circ_0009910			acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"Circ_0009910 is up-regulated in AML bone marrow tissues and AML cell lines and its high expression is associated with worse overall survival and diagnostic potential. Functionally, circ_0009910 promotes AML cell proliferation, cell cycle progression, sphere formation and autophagy while inhibiting apoptosis. Mechanistically, circ_0009910 sponges miR-491-5p to increase B4GALT5 expression and activate PI3K/AKT signaling."	0.8053
34720052	"Cell cycle (Georgetown, Tex.)"	2021	Aloin decelerates the progression of hepatocellular carcinoma through circ_0011385/miR-149-5p/WT1 axis.	hsa_circ_0011385	circ_0011385 			hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0011385 was upregulated in HCC and acted as an oncogenic circRNA that counteracted the anti-tumor effect of aloin. It functioned as a miR-149-5p sponge to increase WT1 expression, thereby promoting HCC cell proliferation and invasion while suppressing apoptosis and autophagy."	0.7092
34724268	"American journal of reproductive immunology (New York, N.Y. : 1989)"	2022	"Circ_0037078 promotes trophoblast cell proliferation, migration, invasion and angiogenesis by miR-576-5p/IL1RAP axis."	hsa_circ_0037078	circ_0037078 	hsa_circ_LRRK1	LRRK1	Preeclampsia 	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR	"circ_0037078/circLRRK1 is a human LRRK1-derived circRNA up-regulated in PE placental tissues. In trophoblast cell models, circ_0037078 knockdown promotes proliferation, migration, invasion and angiogenesis by reducing IL1RAP through sponging miR-576-5p, indicating a circ_0037078/miR-576-5p/IL1RAP ceRNA axis relevant to PE pathophysiology."	0.7945
34724864	"Cell cycle (Georgetown, Tex.)"	2021	Circular RNA circSLC8A1 inhibits the proliferation and invasion of non-small cell lung cancer cells through targeting the miR-106b-5p /FOXJ3 axis.		circSLC8A1	hsa_circ_SLC8A1	SLC8A1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"circSLC8A1 is down-regulated in NSCLC tissues and cell lines. Functional experiments indicate that circSLC8A1 acts as a tumor suppressor by inhibiting NSCLC cell proliferation and invasion. Mechanistically, circSLC8A1 binds and suppresses miR-106b-5p, regulating the miR-106b-5p/FOXJ3 axis and suggesting therapeutic potential in NSCLC."	0.7551
34731384	Journal of bioenergetics and biomembranes	2021	Circ-BNIP3L knockdown alleviates LPS-induced renal tubular epithelial cell injury during sepsis-associated acute kidney injury by miR-370-3p/MYD88 axis.	hsa_circ_0002131	circ-BNIP3L 	hsa_circ_BNIP3L	BNIP3L	Sepsis-associated acute kidney injury 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR	"This study found that circ-BNIP3L is up-regulated in plasma from SA-AKI patients and in LPS-induced HK-2 cells. circ-BNIP3L promotes LPS-induced renal tubular epithelial cell injury by sponging miR-370-3p and up-regulating MYD88, thereby enhancing apoptosis, inflammation, and oxidative stress while inhibiting cell growth."	0.7795
34731387	Biochemical genetics	2022	CircTLK1 Downregulation Attenuates High Glucose-Induced Human Mesangial Cell Injury by Blocking the AKT/NF-kappaB Pathway Through Sponging miR-126-5p/miR-204-5p.	hsa_circ_0004442	circTLK1	hsa_circ_TLK1	TLK1	Diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"In this study, circTLK1 was up-regulated in serum from DN patients and in HG-treated human mesangial cells. CircTLK1 promoted HG-induced inflammation, oxidative stress, and ECM accumulation by sponging miR-126-5p and miR-204-5p to activate the AKT/NF-kappaB pathway. Silencing circTLK1 alleviated mesangial cell injury, suggesting a mechanistic role in DN pathogenesis."	0.7689
34738200	"Cellular oncology (Dordrecht, Netherlands)"	2021	Hsa-circ_0058106 induces EMT and metastasis in laryngeal cancer via sponging miR-153 and inducing Twist1 nuclear translocation.	hsa_circ_0058106		hsa_circ_FN1	FN1	laryngeal cancer	MONDO:0002358	laryngeal carcinoma	up-regulated	RT-qPCR	"hsa-circ_0058106 is upregulated in laryngeal cancer tissues and its high expression is associated with lymph node metastasis and advanced clinical stage. Functionally, it promotes laryngeal cancer cell migration, invasion, EMT, and in vivo metastasis. Mechanistically, it acts as a miR-153 sponge to regulate Snail1 expression and interacts with Twist1 to promote Twist1 nuclear translocation."	0.8399
34738746	Advanced biology	2021	Circular Rims2 Deficiency Causes Retinal Degeneration.	mmu_circ_0000595	Circular Rims2 	mmu_circ_Rims2	Rims2	retinal degeneration 	MONDO:0004580	retinal degeneration	down-regulated	RT-qPCR; ISH; RNA-seq	"circRims2 is a highly expressed mouse retinal circRNA derived from Rims2. AAV-mediated knockdown of circRims2 in mice caused retinal degeneration, retinal thinning, ERG response loss, inflammation, and apoptosis, while circRims2 overexpression inhibited apoptosis in vitro. Mechanistically, circRims2 deficiency activated TNF signaling and reduced A20/Tnfaip3, with a proposed circRims2/miR-667-5p/Tnfaip3 regulatory mechanism."	0.8095
34739167	Oral diseases	2023	Upregulated circ_0002141 facilitates oral squamous cell carcinoma progression via the miR-1231/EGFR axis.	hsa_circ_0002141		hsa_circ_ZDBF2	ZDBF2	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"In this study, circ_0002141 was significantly upregulated in OSCC tissues and cell lines and was associated with advanced clinicopathological features. Functionally, circ_0002141 promoted proliferation, migration and invasion while inhibiting apoptosis. Mechanistically, circ_0002141 acted as a ceRNA by sponging miR-1231 to increase EGFR expression, supporting the circ_0002141/miR-1231/EGFR axis as a potential biomarker and therapeutic target in OSCC."	0.7884
34739656	Journal of molecular histology	2022	CircDLGAP4 overexpression relieves oxygen-glucose deprivation-induced neuronal injury by elevating NEGR1 through sponging miR-503-3p.	hsa_circ_0060180		hsa_circ_DLGAP4	DLGAP4	ischemic stroke 	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR	"CircDLGAP4 is down-regulated in OGD-treated human HCN-2 neuronal cells, an in vitro model of ischemic stroke-related neuronal injury. Its overexpression protects cells by increasing viability and reducing cell death, apoptosis-related protein changes, and inflammatory cytokine release through a circDLGAP4/miR-503-3p/NEGR1 ceRNA axis."	0.7435
34748128	Metabolic brain disease	2022	Circular RNA circ_0070441 regulates MPP+-triggered neurotoxic effect in SH-SY5Y cells via miR-626/IRS2 axis.	hsa_circ_0070441		hsa_circ_SNCA	SNCA	Parkinson's disease 	MONDO:0005180	Parkinson disease	up-regulated	RT-qPCR	"This study found that circ_0070441 is up-regulated in MPP+-treated SH-SY5Y Parkinson's disease cell models. circ_0070441 aggravates MPP+-induced neurotoxicity by sponging miR-626 and increasing IRS2 expression, thereby promoting apoptosis, inflammation and neuronal damage. Knockdown of circ_0070441 showed neuroprotective effects in vitro."	0.6853
34750830	Journal of cellular physiology	2022	Silencing of circARHGAP12 inhibits the progression of atherosclerosis via miR-630/EZH2/TIMP2 signal axis.		circARHGAP12 	mmu_circ_ARHGAP12	ARHGAP12	Atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR; Microarray	"circARHGAP12 is upregulated in atherosclerosis models and ox-LDL-treated MASMCs. Its knockdown suppresses MASMC proliferation and migration, inflammatory factor release, and atherosclerotic plaque formation. Mechanistically, circARHGAP12 binds miR-630 and regulates the EZH2/TIMP2 methylation pathway, affecting MMP2/MMP9-associated migration phenotypes."	0.8233
34751080	Immunopharmacology and immunotoxicology	2022	Circular RNA circCTNNA1 is downregulated in osteoarthritis and sponges miR-29a to suppress LPS-induced apoptosis of synoviocytes.		circCTNNA1	hsa_circ_CTNNA1		osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR	"This study reports that circCTNNA1 is significantly downregulated in synovial fluid from patients with osteoarthritis. Functionally, circCTNNA1 directly interacts with miR-29a and suppresses LPS-induced apoptosis of type B synoviocytes, suggesting a protective role in OA-related synoviocyte injury."	0.6369
34752207	Inhalation toxicology	2021	Circular RNA-CDR1as is involved in lung injury induced by long-term formaldehyde inhalation.		CDR1as 			lung injury induced by FA 	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR	"In this rat formaldehyde inhalation model, CDR1as was significantly upregulated in lung tissues at higher exposure doses and positively correlated with lung injury score and IL-1b. The study suggests that CDR1as may act through a circRNA/miRNA/mRNA regulatory network, especially by suppressing rno-miR-7b and increasing Atg7-associated autophagy, thereby contributing to FA-induced lung injury."	0.4546
34753401	"Hematology (Amsterdam, Netherlands)"	2021	Circ_0000745 regulates NOTCH1-mediated cell proliferation and apoptosis in pediatric T-cell acute lymphoblastic leukemia through adsorbing miR-193b-3p.	hsa_circ_0000745	circ_0000745	hsa_circ_SPECC1	SPECC1	pediatric T-cell acute lymphoblastic leukemia 	MONDO:0000871	T-cell childhood acute lymphocytic leukemia	up-regulated	RT-qPCR	"hsa_circ_0000745/circ_0000745 is up-regulated in T-ALL bone marrow and T-ALL cell lines. It promotes proliferation and cell cycle progression while suppressing apoptosis by sponging miR-193b-3p, relieving repression of NOTCH1 mRNA/protein expression. Its expression is associated with clinical pathological parameters including LDH level and risk stratification."	0.7795
34755307	Cell biology and toxicology	2022	CircRNA hsa_circ_0014130 function as a miR-132-3p sponge for playing oncogenic roles in bladder cancer via upregulating KCNJ12 expression.	hsa_circ_0014130		hsa_circ_PIP5K1A	PIP5K1A	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"hsa_circ_0014130 is up-regulated in bladder cancer tissues and cells, and high expression is associated with lymph node metastasis, advanced TNM stage, and poor survival. Functionally, it promotes proliferation, migration, invasion, differentiation, EMT-related marker expression, and xenograft tumor growth. Mechanistically, it acts as a miR-132-3p sponge to upregulate KCNJ12 and is linked to activation of GSK3beta/AKT signaling."	0.8198
34773528	International journal of clinical oncology	2022	Hsa_circ_0003195 as a biomarker for diagnosis and prognosis of gastric cancer.	hsa_circ_0003195	hsa_ circ_0003195	hsa_circ_TTC27	TTC27	gastric cancer	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"This study found that hsa_circ_0003195 is down-regulated in gastric cancer tissues and patient plasma. Its expression is associated with clinicopathological features and overall survival, supporting its potential use as a noninvasive diagnostic and prognostic biomarker for gastric cancer."	0.6263
34776628	Cytotechnology	2021	Circ-IGF1R plays a significant role in psoriasis via regulation of a miR-194-5p/CDK1 axis.		circ-insulin-like growth factor 1 receptor 	hsa_circ_IGF1R		psoriasis	MONDO:0005083	psoriasis	up-regulated	RT-qPCR	"In an IL-22-stimulated HaCaT cell model of psoriasis, circ-IGF1R is up-regulated and promotes keratinocyte proliferation, migration and invasion while inhibiting apoptosis. Mechanistically, circ-IGF1R acts through the miR-194-5p/CDK1 axis, and knockdown of circ-IGF1R reverses psoriasis-like cellular phenotypes, suggesting a potential therapeutic target."	0.5607
34796777	Autoimmunity	2022	"Circ-METTL15 contributes to the proliferation, metastasis, immune escape and restrains apoptosis in lung cancer by regulating miR-1299/PDL1 axis."	hsa_circ_0000282	circ-METTL15 	hsa_circ_METTL15	METTL15	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; Microarray	"circ-METTL15 is up-regulated in lung cancer tissues and cells and high expression is associated with shorter overall survival. Functionally, circ-METTL15 promotes proliferation, invasion, immune escape and xenograft tumor growth while inhibiting apoptosis. Mechanistically, it functions as a cytoplasmic ceRNA sponge for miR-1299 to up-regulate PDL1 expression."	0.8157
34797473	Journal of thrombosis and thrombolysis	2022	Circ_0003204 knockdown protects endothelial cells against oxidized low-density lipoprotein-induced injuries by targeting the miR-491-5p-ICAM1 pathway.	hsa_circ_0003204	circ_0003204	hsa_circ_USP36	USP36	atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"Circ_0003204 is up-regulated in ox-LDL-treated HUVECs, an in vitro model relevant to atherosclerosis. Its knockdown protects endothelial cells by reducing inflammation and apoptosis while restoring cell viability and tube formation. Mechanistically, circ_0003204 functions as a miR-491-5p sponge to up-regulate ICAM1 through the circ_0003204/miR-491-5p/ICAM1 axis."	0.7406
34799875	Andrologia	2022	Hsa_circ_0074032 promotes prostate cancer progression through elevating homeobox A1 expression by serving as a microRNA-198 decoy.	hsa_circ_0074032	circ_0074032	hsa_circ_SLC25A48	SLC25A48	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"hsa_circ_0074032/circ_0074032 is up-regulated in prostate cancer tissues and cell lines, and high expression is associated with shorter overall survival and adverse clinicopathological features. Functionally, it promotes PCa cell proliferation, migration, invasion and xenograft tumor growth while inhibiting apoptosis. Mechanistically, circ_0074032 acts as a miR-198 sponge to increase HOXA1 expression, forming a circ_0074032/miR-198/HOXA1 regulatory axis."	0.8818
34801649	Brain research bulletin	2022	Hsa_circ_0090002 regulates miR-186-5p/HECTD1 axis to mediate brain microvascular endothelial cell dysfunction.	hsa_circ_0090002	circ_0090002	hsa_circ_PHKA2	PHKA2	ischemic injury 	MONDO:0005053	ischemic disease	down-regulated	RT-qPCR	"Hsa_circ_0090002/circ_0090002 is down-regulated in OGD-stimulated HBMECs and in the MCAO rat model. Its overexpression protects against ischemic injury-related endothelial dysfunction by improving viability and migration while suppressing apoptosis, oxidative stress, cytotoxicity, infarct volume, and neurological deficits. Mechanistically, circ_0090002 functions as a ceRNA for miR-186-5p to increase HECTD1 expression."	0.7446
34813772	Brain research	2022	Circ-CREBBP promotes cell tumorigenesis and glutamine catabolism in glioma by regulating miR-375/glutaminase axis.	hsa_circ_0037655	circ-CREBBP 	hsa_circ_CREBBP	CREBBP	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ-CREBBP is up-regulated in glioma tissues and cells, and its high expression is associated with poor overall survival. Functionally, circ-CREBBP promotes glioma proliferation, migration, invasion, tumor growth and glutamine catabolism while suppressing apoptosis. Mechanistically, it sponges miR-375 to relieve repression of GLS, forming a circ-CREBBP/miR-375/GLS axis."	0.8353
34815051	Analytica chimica acta	2022	A fluorescence strategy for circRNA quantification in tumor cells based on T7 nuclease-assisted cycling enzymatic amplification.		circBART2.2 			nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	Others	"This paper used EBV-encoded circBART2.2 as the target circRNA to develop and validate a fluorescence sensor based on T7 exonuclease-assisted cycling enzymatic amplification. The method detected higher circBART2.2 signals in EBV-positive cancer cell lines and no expression in EBV-negative nasopharyngeal carcinoma cell lines, supporting its potential utility for detecting disease-related circRNAs in real samples."	0.3167
34817912	Oral diseases	2023	Overexpression of circCDR1as drives oral squamous cell carcinoma progression.	hsa_circ_0001946		hsa_circ_CDR1AS		oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circCDR1as is up-regulated in OSCC tissues and cell lines and functions as an oncogenic circRNA. It promotes autophagy, cell cycle progression, proliferation, migration, invasion and in vivo tumor growth while inhibiting apoptosis, mainly through the circCDR1as/miR-876-5p/SLC7A11 ceRNA axis."	0.7554
34822025	Digestive diseases and sciences	2022	Circ_0044556 Promotes the Progression of Colorectal Cancer via the miR-665-Dependent Expression Regulation of Diaphanous Homolog 1.	hsa_circ_0044556		hsa_circ_COL1A1	COL1A1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0044556 is up-regulated in colorectal cancer tissues and cell lines and acts as an oncogenic circRNA. It promotes CRC proliferation, cell cycle progression, migration, invasion, EMT, and tumor growth by sponging miR-665 and increasing DIAPH1 expression. The study also suggests circ_0044556 may serve as a biomarker for CRC diagnosis and treatment management."	0.7595
34823425	Current eye research	2022	Hsa_circ_0000527 Downregulation Suppresses the Development of Retinoblastoma by Modulating the miR-27a-3p/HDAC9 Pathway.	hsa_circ_0000527		hsa_circ_EMC9	EMC9	retinoblastoma 	MONDO:0008380	retinoblastoma	up-regulated	RT-qPCR	"hsa_circ_0000527 is upregulated in retinoblastoma tissues and cells and acts as an oncogenic circRNA. Its knockdown suppresses RB cell proliferation, colony formation, and xenograft tumor growth while promoting apoptosis. Mechanistically, hsa_circ_0000527 decoys miR-27a-3p to regulate HDAC9 and promote activation of the PI3K/AKT pathway."	0.779
34837127	Biochemical genetics	2022	Circ_0084443 Inhibits Wound Healing Via Repressing Keratinocyte Migration Through Targeting the miR-17-3p/FOXO4 Axis.	hsa_circ_0084443	circ_0084443	hsa_circ_PRKDC	PRKDC	wound healing 	MONDO:0021178	injury	down-regulated	RT-qPCR	"Circ_0084443 is downregulated in TGF-beta1-induced human keratinocytes and is mainly cytoplasmic. Functionally, circ_0084443 inhibits TGF-beta1-induced keratinocyte migration by sponging miR-17-3p, thereby increasing FOXO4 expression and suppressing the canonical TGFbeta/SMAD2 signaling pathway. The study suggests circ_0084443 as a potential intervention target for wound-healing-related diseases."	0.6528
34850997	Environmental toxicology	2022	CircSmg5 stimulates the osteogenic differentiation of bone marrow mesenchymal stem cells by targeting the miR-194-5p/Fzd6 axis and beta-catenin signaling.	mmu_circ_0001145	CircSmg5 	mmu_circ_Smg5	Smg5	bone diseases 	MONDO:0005381	bone disorder	up-regulated	RT-qPCR	"CircSmg5 is a mouse Smg5-derived circular RNA that increases during BMSC osteogenic differentiation. It promotes osteogenic differentiation by binding miR-194-5p, relieving repression of Fzd6, and activating Wnt/beta-catenin signaling."	0.7597
34854069	Journal of endocrinological investigation	2022	Circ_0059354 aggravates the progression of papillary thyroid carcinoma by elevating ARFGEF1 through sponging miR-766-3p.	hsa_circ_0059354	circ_0059354	hsa_circ_RASSF2	RASSF2	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	circ_0059354 is up-regulated in PTC tissues and cells and is associated with advanced TNM stage and lymph node metastasis. It promotes malignant PTC phenotypes and in vivo tumor growth by sponging miR-766-3p and increasing ARFGEF1 expression.	0.78
34861803	"Journal of chemotherapy (Florence, Italy)"	2022	Circ_SETD3 regulates gefitinib sensitivity and tumor progression by miR-873-5p-dependent regulation of APPBP2 in non-small cell lung cancer.	hsa_circ_0000567	"circRNA SET domain containing 3, actin histidine"	hsa_circ_SETD3	SETD3	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"Circ_SETD3 is upregulated in gefitinib-resistant NSCLC tissues and cells. It promotes gefitinib resistance and malignant phenotypes by sponging miR-873-5p and increasing APPBP2 expression, while circ_SETD3 knockdown improves gefitinib sensitivity and suppresses tumor progression in vitro and in vivo."	0.786
34866220	Andrologia	2022	Circular RNA circ_0062019 exerts oncogenic properties in prostate cancer via mediating miR-1253/NRBP1 axis.	hsa_circ_0062019	circ_0062019 	hsa_circ_SLC19A1	SLC19A1	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circ_0062019 is up-regulated in prostate cancer tissues and cell lines and acts as an oncogenic circRNA. Mechanistically, it is mainly cytoplasmic and sponges miR-1253 to increase NRBP1 expression, thereby promoting proliferation, migration, invasion, angiogenesis, EMT and tumour growth while suppressing apoptosis. Its circ_0062019/miR-1253/NRBP1 regulatory axis may represent a potential biomarker or therapeutic target for PCa."	0.8443
34871521	"Hematology (Amsterdam, Netherlands)"	2021	The role of circular RNA plasmacytoma variant translocation 1 as a biomarker for prognostication of acute myeloid leukemia.		Circular RNA plasmacytoma variant translocation 1 	hsa_circ_PVT1	PVT1	acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"This study found that circ-PVT1 is up-regulated in bone marrow samples from AML patients compared with disease controls and healthy donors. Higher circ-PVT1 expression is associated with BM blasts, FLT3-ITD mutation, poorer complete remission response, shorter EFS and shorter OS, supporting its role as a prognostic biomarker in AML."	0.5918
34882521	"Cell cycle (Georgetown, Tex.)"	2022	Interfering hsa_circ_0073748 alleviates caerulein-induced ductal cell injury in acute pancreatitis by inhibiting miR-132-3p/TRAF3/NF-kappaB pathway.	hsa_circ_0073748	circ_0073748 	hsa_circ_LMNB1	LMNB1	acute pancreatitis 	MONDO:0006515	acute pancreatitis	up-regulated	RT-qPCR	"hsa_circ_0073748 is upregulated in plasma from AP patients and in caerulein-induced human pancreatic ductal HPDE6-C7 cells. It promotes caerulein-induced ductal cell injury by sponging miR-132-3p, increasing TRAF3 expression, and activating canonical NF-kappaB signaling; circ_0073748 knockdown alleviates injury, inflammation, oxidative stress and apoptosis."	0.7795
34902777	Ecotoxicology and environmental safety	2022	"Combined effect of unfolded protein response and circZc3h4, circRNA Scar in mouse ovary and uterus damage induced by procymidone."		circZc3h4	mmu_circ_Zc3h4	Zc3h4	mouse ovary and uterus damage induced by procymidone 	MONDO:0002263	female reproductive system disorder	down-regulated	RT-qPCR	"circZc3h4 was down-regulated in PCM-induced mouse ovary and uterus damage both in vivo and in cultured tissues. The study links reduced circZc3h4 to increased miR-212, decreased Zc3h4, elevated Jnk1/Jnk2/Jnk3, and consequent follicle and uterine damage, with UPR activation hypothesized to partially counteract this damage at lower PCM doses."	0.5223
34902777	Ecotoxicology and environmental safety	2022	"Combined effect of unfolded protein response and circZc3h4, circRNA Scar in mouse ovary and uterus damage induced by procymidone."		circRNA Scar 			mouse ovary and uterus damage induced by procymidone 	MONDO:0002263	female reproductive system disorder	up-regulated	RT-qPCR	"circRNA Scar was up-regulated in PCM-induced mouse ovary and uterus damage both in vivo and in cultured tissues. The study associates increased circRNA Scar with reduced Atp5b, ATP production barrier, inhibited ovarian and uterine cell proliferation, and aggravated tissue damage, while UPR activation at lower PCM doses was hypothesized to partially antagonize circRNA-related injury."	0.5223
34904327	The journal of gene medicine	2022	Silencing of circDPP4 suppresses cell progression of human prostate cancer and enhances docetaxel cytotoxicity through regulating the miR-564/ZIC2 axis.	hsa_circ_0056881	circDPP4	hsa_circ_DPP4	DPP4	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circDPP4 is up-regulated in prostate cancer tissues and cell lines, with high expression associated with poor overall survival and DTX nonresponsiveness. Functionally, circDPP4 promotes malignant progression and docetaxel resistance, while its knockdown inhibits proliferation, colony formation, migration, invasion, and tumor growth and promotes apoptosis and DTX cytotoxicity. Mechanistically, circDPP4 acts as a cytoplasmic ceRNA sponge for miR-564 to regulate ZIC2 expression."	0.849
34919012	"Cell cycle (Georgetown, Tex.)"	2022	"CircGOT1 promotes cell proliferation, mobility, and glycolysis-mediated cisplatin resistance via inhibiting its host gene GOT1 in esophageal squamous cell cancer."		circGOT1 	hsa_circ_GOT1	GOT1	Esophageal squamous cell cancer 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"circGOT1 is up-regulated in ESCC tissues and cell lines and its high expression is associated with poor survival. It promotes ESCC proliferation, migration, EMT, glycolytic metabolism, tumor growth, and cisplatin resistance while suppressing apoptosis. Mechanistically, circGOT1 acts as a ceRNA for miR-606 to increase GOT1 expression."	0.8703
34919024	"Cell cycle (Georgetown, Tex.)"	2022	Circ_0014235 confers Gefitinib resistance and malignant behaviors in non-small cell lung cancer resistant to Gefitinib by governing the miR-146b-5p/YAP/PD-L1 pathway.	hsa_circ_0014235	circ_0014235	hsa_circ_S100A2	S100A2	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0014235 is up-regulated in Gefitinib-resistant NSCLC cells and promotes Gefitinib resistance, proliferation, colony formation, tumor growth and immune escape while suppressing apoptosis and cell cycle arrest. Mechanistically, circ_0014235 targets miR-146b-5p to relieve inhibition of YAP and regulate PD-L1 expression, forming a circ_0014235/miR-146b-5p/YAP/PD-L1 pathway."	0.795
34919034	"Cell cycle (Georgetown, Tex.)"	2022	Circular RNA circ_0000644 promotes papillary thyroid cancer progression via sponging miR-1205 and regulating E2F3 expression.	hsa_circ_0000644		hsa_circ_KIAA1199	KIAA1199	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"Circ_0000644 is up-regulated in papillary thyroid carcinoma tissues and cells and is associated with larger tumor size and lymph node metastasis. Functionally, circ_0000644 promotes PTC cell growth, migration and invasion and suppresses apoptosis. Mechanistically, it acts as a cytoplasmic ceRNA that sponges miR-1205 to increase E2F3 expression, thereby promoting PTC progression."	0.8344
34922206	Biochemical and biophysical research communications	2022	Circ_LPAR3 promotes the progression of oral squamous cell carcinoma (OSCC).	hsa_circ_0004390	circ_LPAR3 	hsa_circ_LPAR3	LPAR3	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circ_LPAR3 is up-regulated in OSCC and functions as an oncogenic circRNA. It promotes OSCC cell viability, migration, invasion, tumor growth and angiogenesis while suppressing apoptosis, mainly through sponging miR-513b-5p to activate VEGFC and AKT1/p-AKT1 signaling-related effects."	0.7949
34927575	"Journal of chemotherapy (Florence, Italy)"	2023	CircRNA_001895 promotes sunitinib resistance of renal cell carcinoma through regulation of apoptosis and DNA damage repair.		circRNA_001895			renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR	"circRNA_001895 is up-regulated in sunitinib-resistant RCC tissues and resistant RCC cell lines. Functionally, circRNA_001895 promotes sunitinib resistance by supporting proliferation and DNA damage repair while suppressing apoptosis; its knockdown sensitizes RCC cells and xenograft tumors to sunitinib. The study suggests circRNA_001895 as a potential therapeutic target for sunitinib-resistant RCC."	0.6218
34929287	Genomics	2022	Genome-wide circular RNA (circRNA) and mRNA profiling identify a circMET-miR-410-3p regulatory motif for cell growth in colorectal cancer.		circMET 	hsa_circ_MET	MET	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"circMET is up-regulated in CRC-related profiling and functions as a pro-growth circRNA in CRC cells. Mechanistically, circMET sponges miR-410-3p and increases MET expression, forming a circMET-miR-410-3p-MET ceRNA axis that promotes CRC cell proliferation and growth. The study proposes circMET as a potential diagnostic biomarker for CRC."	0.7551
34935248	The journal of obstetrics and gynaecology research	2022	Placental transcriptome sequencing combined with bioinformatics predicts potential genes and circular RNAs associated with hemoglobin Bart's hydrops fetalis syndrome.	hsa_circ_0003961	circ_hsa_0003961			Hemoglobin Bart's hydrops fetalis syndrome 	MONDO:0015579	Hb Bart's hydrops fetalis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0003961 was identified by placental RNA-seq and validated by RT-qPCR and Sanger sequencing as upregulated in BHFS placenta. The study predicts that it may participate in a ceRNA network involving hsa-miR-629-5p, hsa-miR-1299 and hsa-miR-625-5p, with potential links to SOX6 and placental cell proliferation, apoptosis, platelet and hematopoietic processes."	0.5135
34935248	The journal of obstetrics and gynaecology research	2022	Placental transcriptome sequencing combined with bioinformatics predicts potential genes and circular RNAs associated with hemoglobin Bart's hydrops fetalis syndrome.	hsa_circ_0006687	circ_hsa_0006687			Hemoglobin Bart's hydrops fetalis syndrome 	MONDO:0015579	Hb Bart's hydrops fetalis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0006687 was identified by placental RNA-seq and validated by RT-qPCR and Sanger sequencing as upregulated in BHFS placenta. The study predicts that it may act through a ceRNA network and co-expression relationships with adhesion- and angiogenesis-related genes, suggesting roles in placental cell adhesion, angiogenesis, hematopoietic and immune-related processes and possible biomarker value for BHFS."	0.5135
34951563	"Cell cycle (Georgetown, Tex.)"	2022	Depleting circ_0088364 restrained cell growth and motility of human hepatocellular carcinoma via circ_0088364-miR-1270-COL4A1 ceRNA pathway.	hsa_circ_0088364	circ_0088364			hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"hsa_circ_0088364/circ_0088364 is upregulated in HCC tumors and HCC cell lines. It acts as an oncogenic circRNA that promotes proliferation, cell cycle progression, migration, invasion, EMT and xenograft tumor growth while suppressing apoptosis, mainly through the circ_0088364-miR-1270-COL4A1 ceRNA axis. Its knockdown suppresses HCC growth and motility, suggesting potential therapeutic relevance."	0.7294
34957935	"Hematology (Amsterdam, Netherlands)"	2022	Circ_0000745 promotes acute lymphoblastic leukemia progression through mediating miR-494-3p/NET1 axis.	hsa_circ_0000745	circ_0000745	hsa_circ_SPECC1	SPECC1	acute lymphoblastic leukemia 	MONDO:0004967	acute lymphoblastic leukemia	up-regulated	RT-qPCR	"circ_0000745 is up-regulated in peripheral blood samples from ALL patients and in ALL cell lines. Functionally, circ_0000745 promotes ALL cell cycle progression and glycolytic metabolism while inhibiting apoptosis and ferroptosis. Mechanistically, it acts as a miR-494-3p sponge to up-regulate NET1 expression, suggesting the circ_0000745/miR-494-3p/NET1 axis as a potential diagnostic and therapeutic target in ALL."	0.8111
34961410	Current eye research	2022	Circ-MKLN1/miR-377-3p/CTGF Axis Regulates the TGF-beta2-induced Posterior Capsular Opacification in SRA01/04 Cells.	hsa_circ_0003047	circRNA-muskelin 	hsa_circ_MKLN1	MKLN1	posterior capsular opacification 	MONDO:0005129	cataract	up-regulated	RT-qPCR	"Circ-MKLN1 is up-regulated in PCO lens samples and TGF-beta2-treated SRA01/04 cells. It promotes PCO-related cell viability, migration, invasion and EMT by sponging miR-377-3p and increasing CTGF expression, suggesting potential value as a therapeutic target for PCO."	0.7404
34963405	Current eye research	2022	Circ_0000527 Drives Retinoblastoma Progression by Regulating miR-1236-3p/SMAD2 Pathway.	hsa_circ_0000527	circ_0000527	hsa_circ_FAM158A	FAM158A	retinoblastoma 	MONDO:0008380	retinoblastoma	up-regulated	RT-qPCR	"Circ_0000527 is up-regulated in retinoblastoma tissues and cells and is associated with aggressive clinicopathological features. Functionally, circ_0000527 promotes RB proliferation, migration, invasion, angiogenesis and tumor growth while suppressing apoptosis. Mechanistically, it sponges miR-1236-3p to increase SMAD2 expression, supporting RB progression through the circ_0000527/miR-1236-3p/SMAD2 axis."	0.8299
34979261	Neuroscience	2022	Circ_0001665 Contributes to the Occurrence of Vestibular Schwannoma via Targeting miR-302a-3p/Adam9/EGFR Signaling Pathway.	mmu_circ_0001665	circ_0001665 	mmu_circ_Adam9	Adam9	Vestibular schwannoma 	MONDO:0001569	acoustic neuroma	up-regulated	RT-qPCR	"circ_0001665 is up-regulated in vestibular schwannoma cells and contributes to malignant cellular behaviors by promoting proliferation and suppressing apoptosis. Mechanistically, it sponges miR-302a-3p to increase Adam9 expression and activate the EGFR signaling pathway."	0.809
34982356	Neurotoxicity research	2022	Circ_0001588 Upregulates ERBB4 to Promote Glioma Malignant Progression Through Sponging miR-1281.	hsa_circ_0001588	circ_0001588	hsa_circ_HISTIH4E		glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ_0001588 is upregulated in glioma tissues and cells and its high expression is associated with larger tumor size, higher WHO grade, and poorer survival. Functionally, circ_0001588 promotes glioma cell proliferation, migration, invasion, angiogenic tube formation and in vivo tumor growth while suppressing apoptosis. Mechanistically, cytoplasmic circ_0001588 sponges miR-1281 to upregulate ERBB4, forming a circ_0001588/miR-1281/ERBB4 oncogenic axis."	0.8354
34987010	Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver	2022	CircRNA-ABCB10 promotes gastric cancer progression by sponging miR-1915-3p to upregulate RaC1.		Circ-ABCB10	hsa_circ_ABCB10	ABCB10	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ-ABCB10 is upregulated in gastric cancer tissues and cell lines and is associated with poorer overall survival. Functionally, circ-ABCB10 promotes GC cell growth, migration, invasion, cell cycle progression, and xenograft tumor growth while inhibiting apoptosis. Mechanistically, it acts through a circ-ABCB10/miR-1915-3p/Rac1 ceRNA axis and may represent a diagnostic or therapeutic target for GC."	0.7986
34988777	Biochemical genetics	2022	CircFBXW8 Acts an Oncogenic Role in the Malignant Progression of Non-small Cell Lung Carcinoma by miR-370-3p-Dependent Regulation of TRIM44.		circFBXW8 	hsa_circ_FBXW8	FBXW8	Non-small cell lung carcinoma 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circFBXW8 is up-regulated in NSCLC tissues, NSCLC cell lines, and exosomes from NSCLC cells. It functions as an oncogenic circRNA by sponging miR-370-3p to increase TRIM44 expression, thereby promoting proliferation, migration, invasion, EMT-like marker changes and xenograft tumor formation while inhibiting apoptosis. Its secretion is mediated by exosomes, and circFBXW8 inhibition is proposed as a potential therapeutic strategy for NSCLC."	0.8006
34988853	Molecular and cellular biochemistry	2022	Homo sapiens circular RNA 0003602 (Hsa_circ_0003602) accelerates the tumorigenicity of acute myeloid leukemia by modulating miR-502-5p/IGF1R axis.	hsa_circ_0003602		hsa_circ_SMARCC1	SMARCC1	acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"hsa_circ_0003602 is up-regulated in AML bone marrow samples and AML cell lines, and high expression is associated with poor survival. Functionally, it promotes AML cell proliferation, migration and invasion while inhibiting apoptosis. Mechanistically, it acts as a ceRNA sponge for miR-502-5p to upregulate IGF1R, forming a hsa_circ_0003602/miR-502-5p/IGF1R axis that accelerates AML progression."	0.7779
34993722	Biochemical genetics	2022	Circ_0044516 Enriches the Level of SARM1 as a miR-330-5p Sponge to Regulate Cell Malignant Behaviors and Tumorigenesis of Prostate Cancer.	hsa_circ_0044516	circ_0044516	hsa_circ_COL1A1	COL1A1	Prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circ_0044516 is up-regulated in prostate cancer tissues and cell lines. It promotes malignant PCa behaviors and tumor growth by sponging miR-330-5p and increasing SARM1 expression, while circ_0044516 knockdown suppresses proliferation, migration, invasion and cell cycle progression and promotes apoptosis."	0.7052
34994105	Small methods	2022	Silencing Gene-Engineered Injectable Hydrogel Microsphere for Regulation of Extracellular Matrix Metabolism Balance.		circSTC2	rno_circ_STC2	STC2	intervertebral disc degeneration 	MONDO:0011385	intervertebral disk degenerative disorder	up-regulated	RT-qPCR; Microarray	"This study investigates circSTC2 as a silencing target for intervertebral disc degeneration under nutrient-restricted conditions. A HAMA hydrogel microsphere delivery system carrying circSTC2-silencing lipoplexes suppresses circSTC2 expression in NP cells, promotes ECM anabolic markers, reduces ECM catabolic proteases, restores NP tissue integrity, and inhibits IVD degeneration in a rat model."	0.5802
34994952	Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico	2022	circRNA CRIM1 regulates the migration and invasion of bladder cancer by targeting miR182/Foxo3a axis.		circRNA CRIM1 	hsa_circ_CRIM1	CRIM1	bladder cancer	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR	"circRNA CRIM1 is down-regulated in bladder cancer tissues and cell lines and its expression is associated with distal migration. Functional assays indicate that circRNA CRIM1 overexpression suppresses bladder cancer cell migration and invasion. Mechanistically, circRNA CRIM1 acts through the miR-182/Foxo3a axis, reducing miR-182 and increasing Foxo3a mRNA/protein expression, suggesting tumor-suppressive and potential therapeutic relevance."	0.7078
34997455	Journal of physiology and biochemistry	2022	Circ_0092291 attenuates angiotensin II-induced cell damages in human aortic vascular smooth muscle cells via mediating the miR-626/COL4A1 signal axis.	hsa_circ_0092291	circ_0092291			Abdominal aortic aneurysm 	MONDO:0005350	abdominal aortic aneurysm	down-regulated	RT-qPCR	"circ_0092291 is down-regulated in AAA patient samples and Ang II-treated human aortic vascular smooth muscle cells. Its overexpression protects against Ang II-induced inflammatory injury, apoptosis, angiopoiesis repression, and ECM-related damage by sponging miR-626 and increasing COL4A1 expression. The study proposes the circ_0092291/miR-626/COL4A1 axis as a potential molecular mechanism and therapeutic target in AAA."	0.7277
35000195	Annals of the New York Academy of Sciences	2022	CircABCC1 promotes the development of glioma by sponging miR-591 and modulating high-mobility group A2.		CircABCC1 	hsa_circ_ABCC1	ABCC1	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; ISH	"CircABCC1 is up-regulated in human glioma tissues and cell lines and functions as an oncogenic circRNA. Its knockdown suppresses glioma proliferation, colony formation, migration, invasion, and xenograft tumor growth while promoting apoptosis. Mechanistically, circABCC1 sponges miR-591 to relieve repression of HMGA2, forming a circABCC1/miR-591/HMGA2 ceRNA axis with potential therapeutic relevance."	0.7302
35001739	Autoimmunity	2022	Circ_0003645 serves as miR-335-5p sponge to promote the biological process of diffuse large B-cell lymphoma by upregulating NFIB.	hsa_circ_0003645	circ_0003645			diffuse large B-cell lymphoma 	MONDO:0018905	diffuse large B-cell lymphoma	up-regulated	RT-qPCR	"circ_0003645 is up-regulated in DLBCL tumour tissues and cell lines. It promotes DLBCL cell proliferation, cell cycle progression and glycolysis while inhibiting apoptosis, at least partly by sponging miR-335-5p and upregulating NFIB. The study suggests circ_0003645 as a potential therapeutic target for DLBCL."	0.7785
35012421	Immunological investigations	2022	"Circ_0020093 Overexpression Alleviates Interleukin-1 Beta-induced Inflammation, Apoptosis and Extracellular Matrix Degradation in Human Chondrocytes by Targeting the miR-181a-5p/ERG Pathway."	hsa_circ_0020093	circ_0020093	hsa_circ_ATRNL1	ATRNL1	Osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR	"Circ_0020093 is down-regulated in OA serum samples and IL-1beta-treated human chondrocytes. Its overexpression protects chondrocytes by promoting proliferation and suppressing inflammation, apoptosis and ECM degradation. Mechanistically, circ_0020093 sponges miR-181a-5p to relieve repression of ERG, and it also shows potential diagnostic value for OA."	0.8322
35013754	Lung	2022	CircMIIP Contributes to Non-Small Cell Lung Cancer Progression by Binding miR-766-5p to Upregulate FAM83A Expression.	hsa_circ_0009932	 circ-MIIP	hsa_circ_MIIP	MIIP	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"CircMIIP is up-regulated in NSCLC tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation, migration, invasion and tumor growth while inhibiting apoptosis, mainly by sponging miR-766-5p to increase FAM83A expression. Its knockdown suppresses malignant phenotypes in vitro and xenograft tumor growth in vivo, suggesting therapeutic potential in NSCLC."	0.7554
35015267	Human cell	2022	Circular RNA circ_0008934 promotes hepatocellular carcinoma growth and metastasis through modulating miR-1305/TMTC3 axis.	hsa_circ_0008934	circ_0008934	hsa_circ_ASAP1	ASAP1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ_0008934 is up-regulated in HCC tissues and cell lines and high expression predicts poor overall survival and aggressive clinicopathological features. Functionally, circ_0008934 promotes HCC proliferation, invasion, migration, tumor growth and lung metastasis. Mechanistically, it acts as a miR-1305 sponge to increase TMTC3 expression, forming a circ_0008934/miR-1305/TMTC3 regulatory axis."	0.8709
35023052	"Reproductive sciences (Thousand Oaks, Calif.)"	2022	"Circ_0003221 Downregulation Restrains Cervical Cancer Cell Growth, Metastasis and Angiogenesis by Governing the miR-139-3p/S100A14 Pathway."	hsa_circ_0003221	circ_0003221	hsa_circ_PTK2	PTK2	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ_0003221 is up-regulated in cervical cancer tissues and cell lines and high expression is associated with poor 5-year overall survival. Functionally, circ_0003221 promotes cervical cancer cell proliferation, migration, invasion, angiogenesis, EMT-related malignant phenotypes, and xenograft tumor growth. Mechanistically, cytoplasmic circ_0003221 sponges miR-139-3p and thereby positively regulates S100A14 expression through the circ_0003221/miR-139-3p/S100A14 axis."	0.8174
35030455	Leukemia research	2022	Circ_SEC61A1 contributes to the progression of multiple myeloma cells via regulating miR-660-5p/CDK6 axis.	hsa_circ_0007841	Circ_SEC61A1 	hsa_circ_SEC61A1	SEC61A1	multiple myeloma 	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR	"Circ_SEC61A1 is up-regulated in multiple myeloma tissues and cells and functions as an oncogenic circRNA. It mainly localizes in the cytoplasm, sponges miR-660-5p, and increases CDK6 expression, thereby promoting proliferation, migration, invasion, metastasis-related/EMT phenotypes and inhibiting apoptosis in MM cells. The study suggests circ_SEC61A1 may be a potential therapeutic target for MM."	0.742
35032276	Metabolic brain disease	2022	Sevoflurane represses the progression of glioma by the regulation of circ_0037655/miR-130a-5p/RPN2 axis.	hsa_circ_0037655	circ_00037655 	hsa_circ_CREBBP		glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"Circ_0037655 is up-regulated in glioma tissues and cell lines, and sevoflurane treatment suppresses its expression. Functionally, circ_0037655 overexpression weakens the anti-tumor effects of sevoflurane by restoring glioma cell proliferation, migration, invasion and EMT while reducing apoptosis. Mechanistically, circ_0037655 acts through the circ_0037655/miR-130a-5p/RPN2 axis to promote RPN2 expression."	0.7296
35032277	Metabolic brain disease	2022	Knockdown of circ_0007290 alleviates oxygen-glucose deprivation-induced neuronal injury by regulating miR-496/PDCD4 axis.	hsa_circ_0007290	circ_0007290 	hsa_circ_FUNDC1	FUNDC1	ischemic stroke 	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; Microarray	"circ_0007290 is up-regulated in plasma from AIS patients and in OGD-treated HCN-2 cells. Its knockdown protects against OGD-induced neuronal injury by promoting cell proliferation and reducing LDH release, apoptosis, and inflammatory cytokines. Mechanistically, circ_0007290 sponges miR-496 to up-regulate PDCD4 in a circ_0007290/miR-496/PDCD4 ceRNA axis."	0.7893
35034245	Biochemical genetics	2022	Circ-FAT1 Up-Regulates FOSL2 Expression by Sponging miR-619-5p to Facilitate Colorectal Cancer Progression.		circ-FAT1 	hsa_circ_FAT1	FAT1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ-FAT1 is up-regulated in colorectal cancer tissues and cells and functions as a tumor-promoting circRNA. Mechanistically, cytoplasmic circ-FAT1 sponges miR-619-5p to relieve repression of FOSL2, thereby promoting CRC cell proliferation, migration, invasion, angiogenesis, and xenograft tumor growth while suppressing apoptosis. The study suggests circ-FAT1 as a potential therapeutic target in CRC."	0.8175
35034254	Molecular and cellular biochemistry	2022	Circ_0025039 acts an oncogenic role in the progression of non-small cell lung cancer through miR-636-dependent regulation of CORO1C.	hsa_circ_0025039	circ_0025039 	hsa_circ_FOXM1	FOXM1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0025039 is up-regulated in NSCLC tissues and cell lines and acts as an oncogenic circRNA. Its knockdown suppresses proliferation, migration, invasion, tube formation, sphere formation and xenograft tumor growth while promoting apoptosis. Mechanistically, circ_0025039 sponges miR-636 to increase CORO1C expression, supporting its potential as a therapeutic target in NSCLC."	0.8443
35037349	The journal of gene medicine	2022	Circ_0006006 facilitates non-small cell lung cancer progression by modulating miR-924/SRSF7 axis.	hsa_circ_0006006	CircularRNA_0006006 	hsa_circ_PDK1	PDK1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"Circ_0006006 is up-regulated in NSCLC tissues and cell lines. It functions as an oncogenic circRNA by sponging miR-924 to increase SRSF7 expression, thereby promoting proliferation, migration, invasion, angiogenesis and tumor growth while suppressing apoptosis."	0.8299
35038081	Metabolic brain disease	2022	EIF4A3-induced circCCNB1 (hsa_circ_0001495) promotes glioma progression by elevating CCND1 through interacting miR-516b-5p and HuR.	hsa_circ_0001495	circRNA cyclin B1 	hsa_circ_CCNB1	CCNB1	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR; Microarray	"circCCNB1 is up-regulated in glioma tissues and cell lines and functions as an oncogenic circRNA. EIF4A3 induces circCCNB1 expression, while circCCNB1 promotes glioma proliferation, cell cycle progression and xenograft tumor growth by elevating CCND1 through miR-516b-5p sponging and HuR-mediated CCND1 mRNA stabilization."	0.8571
35039980	Biochemical genetics	2022	Circ_0000467 Exerts an Oncogenic Role in Colorectal Cancer via miR-330-5p-Dependent Regulation of TYRO3.	hsa_circ_0000467	circ_0000467	hsa_circ_SKA3	SKA3	Colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"Circ_0000467 is upregulated in CRC tissues and cell lines and functions as an oncogenic circRNA. It promotes CRC proliferation, migration, invasion, glycolysis, cell cycle progression, and tumor growth by sponging miR-330-5p to increase TYRO3 expression, while suppressing apoptosis."	0.8254
35039980	Biochemical genetics	2022	Circ_0000467 Exerts an Oncogenic Role in Colorectal Cancer via miR-330-5p-Dependent Regulation of TYRO3.	hsa_circ_0084615	circ_0084615			Colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	Circ_0084615 was identified from CRC-related microarray datasets and validated by qRT-PCR as significantly upregulated in CRC tumor tissues compared with adjacent normal tissues. No functional mechanism or interaction partner was further investigated for this circRNA in the study.	0.4032
35039980	Biochemical genetics	2022	Circ_0000467 Exerts an Oncogenic Role in Colorectal Cancer via miR-330-5p-Dependent Regulation of TYRO3.	hsa_circ_0006174	circ_0006174			Colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	Circ_0006174 was identified from CRC-related microarray datasets and validated by qRT-PCR as significantly upregulated in CRC tumor tissues compared with adjacent normal tissues. No functional mechanism or interaction partner was further investigated for this circRNA in the study.	0.4032
35039980	Biochemical genetics	2022	Circ_0000467 Exerts an Oncogenic Role in Colorectal Cancer via miR-330-5p-Dependent Regulation of TYRO3.	hsa_circ_0000518	circ_0000518			Colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	Circ_0000518 was identified from CRC-related microarray datasets and validated by qRT-PCR as significantly upregulated in CRC tumor tissues compared with adjacent normal tissues. No functional mechanism or interaction partner was further investigated for this circRNA in the study.	0.4032
35039981	Biochemical genetics	2022	Circular RNA circKIF2A Contributes to the Progression of Neuroblastoma Through Regulating PRPS1 Expression by Sponging miR-377-3p.	hsa_circ_0129276	circKIF2A 	hsa_circ_KIF2A	KIF2A	neuroblastoma	MONDO:0005072	neuroblastoma	up-regulated	RT-qPCR	"circKIF2A is up-regulated in neuroblastoma tissues and cell lines and functions as an oncogenic circRNA. Its knockdown inhibits proliferation, migration, invasion, metastasis, glycolysis, and xenograft tumor growth while promoting apoptosis. Mechanistically, cytoplasmic circKIF2A sponges miR-377-3p to increase PRPS1 expression, forming a circKIF2A/miR-377-3p/PRPS1 ceRNA axis."	0.8443
35048507	Environmental toxicology	2022	CircFAM64A enhances cellular processes in triple-negative breast cancer by targeting the miR-149-5p/CDT1 axis.	hsa_circ_0041732	circFAM64A	hsa_circ_FAM64A	FAM64A	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; Microarray	"CircFAM64A is up-regulated in TNBC tissues and cell lines and acts as an oncogenic circRNA. It promotes proliferation, cell cycle progression, migration, and invasion by sponging miR-149-5p and increasing CDT1 expression, suggesting potential value as a diagnostic biomarker and therapeutic target."	0.8118
35050425	Biochemical genetics	2022	CircPLK1 Acts as a Carcinogenic Driver to Promote the Development of Malignant Pleural Mesothelioma by Governing the miR-1294/HMGA1 Pathway.	hsa_circ_0038632	circ-PLK1	hsa_circ_PLK1	PLK1	malignant pleural mesothelioma 	MONDO:0005112	malignant pleural mesothelioma	up-regulated	RT-qPCR	"CircPLK1 is up-regulated in MPM tissues, cell lines and serum-derived exosomes, and high expression is associated with poor overall survival and diagnostic potential. Functionally, circPLK1 promotes MPM proliferation, cell-cycle progression, migration, invasion, stemness and xenograft tumor growth. Mechanistically, circPLK1 acts as a cytoplasmic ceRNA that sponges miR-1294 to increase HMGA1 expression."	0.8583
35050446	Metabolic brain disease	2022	Knockdown of circHECTD1 inhibits oxygen-glucose deprivation and reperfusion induced endothelial-mesenchymal transition.		circHECTD1 	hsa_circ_HECTD1	HECTD1	Ischemic stroke 	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR	"This study found that circHECTD1 is upregulated in ischemic stroke models, including MCAO mouse brain tissues and OGD/R-treated HCMECs. Functional experiments indicate that circHECTD1 knockdown suppresses OGD/R-induced EndoMT and affects endothelial migration and tube formation. Mechanistically, circHECTD1 sponges miR-335 to regulate NOTCH2, suggesting a circHECTD1/miR-335/NOTCH2 axis in ischemic stroke-related endothelial dysfunction."	0.627
35050446	Metabolic brain disease	2022	Knockdown of circHECTD1 inhibits oxygen-glucose deprivation and reperfusion induced endothelial-mesenchymal transition.		circHECTD1 	mmu_circ_HECTD1	HECTD1	Ischemic stroke 	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR	"This study found that circHECTD1 is upregulated in ischemic stroke models, including MCAO mouse brain tissues and OGD/R-treated HCMECs. Functional experiments indicate that circHECTD1 knockdown suppresses OGD/R-induced EndoMT and affects endothelial migration and tube formation. Mechanistically, circHECTD1 sponges miR-335 to regulate NOTCH2, suggesting a circHECTD1/miR-335/NOTCH2 axis in ischemic stroke-related endothelial dysfunction."	0.627
35059934	Biochemical genetics	2022	Knockdown circZNF131 Inhibits Cell Progression and Glycolysis in Gastric Cancer Through miR-186-5p/PFKFB2 Axis.	hsa_circ_0001479		hsa_circ_ZNF131	ZNF131	Gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circZNF131 is upregulated in gastric cancer tissues and cells and acts as an oncogenic circRNA. Its knockdown suppresses colony formation, migration, invasion, glycolysis, and xenograft tumor growth while inducing apoptosis. Mechanistically, circZNF131 sponges miR-186-5p to increase PFKFB2 expression, forming a circZNF131/miR-186-5p/PFKFB2 ceRNA axis."	0.7661
35060046	Environmental science and pollution research international	2022	Circular RNA circ_0005835 promotes promoted neural stem cells proliferation and differentiate to neuron and inhibits inflammatory cytokines levels through miR-576-3p in Alzheimer's disease.	hsa_circ_0005835	circ_0005835			Alzheimer's disease 	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR	"circ_0005835 is upregulated in serum from AD patients and in Abeta-treated SH-SY5Y and BV2 cell models. Functionally, circ_0005835 appears to promote AD-related neurotoxicity by inducing inflammatory cytokines and reducing neuronal viability, while its knockdown suppresses neuroinflammation and promotes NSC proliferation and neuronal differentiation. Mechanistically, the study supports a circ_0005835/miR-576-3p regulatory relationship."	0.6479
35064359	Biochemical genetics	2022	CircRNA CORO1C Regulates miR-654-3p/USP7 Axis to Mediate Laryngeal Squamous Cell Carcinoma Progression.	hsa_circ_0028074	circRNA coronin-1C 	hsa_circ_CORO1C	CORO1C	laryngeal squamous cell carcinoma 	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR	"circ_CORO1C is up-regulated in LSCC tissues and cell lines. Functionally, circ_CORO1C promotes LSCC progression by enhancing proliferation, cell cycle progression, migration, invasion, EMT and xenograft tumor growth while suppressing apoptosis. Mechanistically, it acts through the miR-654-3p/USP7 regulatory axis."	0.786
35064360	Biochemical genetics	2022	Circ-ATIC Serves as a Sponge of miR-326 to Accelerate Esophageal Squamous Cell Carcinoma Progression by Targeting ID1.	hsa_circ_0058063	circ-ATIC 	hsa_circ_ATIC	ATIC	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"Circ-ATIC is upregulated in ESCC tissues and cell lines and correlates positively with tumor stage. Functionally, circ-ATIC promotes ESCC proliferation, migration, invasion, metastasis and tumor growth while inhibiting apoptosis and oxidative stress. Mechanistically, it sponges miR-326 to increase ID1 expression, forming a circ-ATIC/miR-326/ID1 regulatory axis."	0.7052
35064448	Immunologic research	2022	Microarray profiling and functional analysis reveal the regulatory role of differentially expressed plasma circular RNAs in Hashimoto's thyroiditis.	hsa_circ_0008193				Hashimoto's thyroiditis 	MONDO:0007699	Hashimoto thyroiditis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0008193 is an upregulated circRNA in Hashimoto's thyroiditis plasma, validated by RT-qPCR. It likely acts as a ceRNA by sponging multiple miRNAs and is implicated in chemokine signaling and immune-related regulation, potentially contributing to immune activation/maintenance in HT."	0.4297
35064448	Immunologic research	2022	Microarray profiling and functional analysis reveal the regulatory role of differentially expressed plasma circular RNAs in Hashimoto's thyroiditis.	hsa_circ_0003022				Hashimoto's thyroiditis 	MONDO:0007699	Hashimoto thyroiditis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0003022 was one of the upregulated circRNAs identified in plasma by microarray and tested by RT-qPCR in PBMCs, but its change was not statistically significant in validation. The study does not provide a clear mechanism or disease-related function for this circRNA."	0.3588
35064875	Molecular and cellular biochemistry	2022	Transcriptome of visceral adipose tissue identifies an inflammation-related ceRNA network that regulates obesity.	hsa_circ_0003000		hsa_circ_ORC5	ORC5	obesity	MONDO:0011122	obesity disorder	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0003000, named circORC5, is down-regulated in visceral adipose tissue from obese individuals. The study proposes that circORC5 participates in an inflammation-related ceRNA network, including circORC5/miR-197-5p/TNFRSF10D and additional predicted miRNA-target interactions involving miR-1226-3p, miR-6780a-5p, XCR1 and CARD11."	0.5135
35064875	Molecular and cellular biochemistry	2022	Transcriptome of visceral adipose tissue identifies an inflammation-related ceRNA network that regulates obesity.	hsa_circ_0139142	hsa_ circ_0139142 	hsa_circ_NTRK2	NTRK2	obesity	MONDO:0011122	obesity disorder	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0139142, named circNTRK2, is down-regulated in visceral adipose tissue from obese individuals. The study links circNTRK2 to an inflammation-related ceRNA network, especially the circNTRK2/miR-760/LAT axis, suggesting potential relevance as an obesity biomarker or regulatory RNA."	0.5135
35064875	Molecular and cellular biochemistry	2022	Transcriptome of visceral adipose tissue identifies an inflammation-related ceRNA network that regulates obesity.	hsa_circ_0000545	hsa-circ-0000545			obesity	MONDO:0011122	obesity disorder	down-regulated	RNA-seq	"hsa_circ_0000545 was selected from RNA-seq-based differentially expressed circRNAs for construction of an inflammation-related ceRNA network in obesity. Unlike circORC5 and circNTRK2, the provided text does not report successful RT-qPCR validation for this circRNA, so its disease association is supported mainly by sequencing and bioinformatic network analysis."	0.329
35066205	Thrombosis research	2022	Hsa_circ_0001020 accelerates the lower extremity deep vein thrombosis via sponging miR-29c-3p to promote MDM2 expression.	hsa_circ_0001020	circ_0001020 	hsa_circ_UGP2	UGP2	lower extremity deep vein thrombosis 	MONDO:0000831	thrombotic disease	up-regulated	RT-qPCR; ISH; Microarray	"hsa_circ_0001020 is up-regulated in peripheral blood from DVT patients and is mainly localized in the cytoplasm of EPCs. It promotes DVT progression by sponging miR-29c-3p to increase MDM2 expression, thereby inhibiting EPC migration, invasion, angiogenesis, and thrombus-resolution-related homing. Knockdown of hsa_circ_0001020 suppresses thrombosis in a DVT mouse model, suggesting therapeutic potential."	0.8108
35066780	Immunologic research	2022	CircCBFB is a mediator of hepatocellular carcinoma cell autophagy and proliferation through miR-424-5p/ATG14 axis.		circCBFB 	hsa_circ_CBFB	CBFB	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circCBFB is up-regulated in HCC tissues and cell lines and its high expression is associated with poor 5-year survival. Functionally, circCBFB promotes HCC cell proliferation, cell cycle progression, and autophagy while inhibiting apoptosis. Mechanistically, it acts as a cytoplasmic ceRNA that sponges miR-424-5p to upregulate ATG14."	0.7855
35074490	International journal of cardiology	2022	Mechanism of CircANKRD36 regulating cell heterogeneity and endothelial mesenchymal transition in aortic valve stromal cells by regulating miR-599 and TGF-beta signaling pathway.		CircANKRD36	hsa_circ_ANKRD36	ANKRD36	calcific aortic valve disease 	MONDO:0003803	aortic valve disorder	down-regulated	RT-qPCR	"circANKRD36 is down-regulated in human CAVD tissues and in VICs after osteogenic stimulation. The study suggests that circANKRD36 suppresses miR-599 and TGF-beta signaling, thereby inhibiting VIC osteogenic differentiation, endothelial transition-related changes, and calcified nodule formation. The circANKRD36-miR-599-TGF-beta axis is proposed as a potential theoretical basis for CAVD treatment."	0.6369
35075616	"Reproductive sciences (Thousand Oaks, Calif.)"	2022	Hsa_circ_0074269-mediated Upregulation of TUFT1 Through miR-485-5p Increases Cisplatin Resistance in Cervical Cancer.	hsa_circ_0074269	circ_0074269			cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"Hsa_circ_0074269/circ_0074269 is upregulated in DDP-resistant cervical cancer samples, cells, and exosomes. It promotes cisplatin resistance, tumor growth, proliferation, and migration while suppressing apoptosis through a ceRNA mechanism involving miR-485-5p-mediated regulation of TUFT1. The study supports circ_0074269 as a potential therapeutic target for overcoming DDP resistance in cervical cancer."	0.8175
35075668	Journal of medical virology	2022	Redondoviridae infection regulates circRNAome in periodontitis.		circCOL1A1	hsa_circ_COL1A1	COL1A1	periodontitis 	MONDO:0005076	periodontitis	up-regulated	RNA-seq	circCOL1A1 is up-regulated in periodontitis gingival tissues and was highlighted as a key circRNA in Redondoviridae-related periodontitis. The study predicts that circCOL1A1 may act through a ceRNA network involving miR-6754-5p/miR-205-5p and target mRNAs such as MMP2.	0.348
35075668	Journal of medical virology	2022	Redondoviridae infection regulates circRNAome in periodontitis.		circAASS	hsa_circ_AASS	AASS	periodontitis 	MONDO:0005076	periodontitis	up-regulated	RT-qPCR; RNA-seq	"circAASS is up-regulated in Redondoviridae-positive periodontitis gingival tissues and was validated by qRT-PCR. The study predicts that circAASS may function as a miRNA sponge for miR-6749-3p, miR-320a-5p and miR-4750-3p, linking it to PI3K-Akt, focal adhesion and related pathways."	0.4032
35075668	Journal of medical virology	2022	Redondoviridae infection regulates circRNAome in periodontitis.	hsa_circ_0007786	circPTK2 	hsa_circ_PTK2	PTK2	periodontitis 	MONDO:0005076	periodontitis	up-regulated	RT-qPCR; RNA-seq	"circPTK2 is reported as a key circRNA associated with Redondoviridae-related periodontitis and was validated by qRT-PCR among the selected differentially expressed circRNAs. It was incorporated into predicted circRNA-miRNA-mRNA network analyses, although specific partners were not detailed in the supplied text."	0.4032
35075668	Journal of medical virology	2022	Redondoviridae infection regulates circRNAome in periodontitis.		circATP2B4	hsa_circ_ATP2B4	ATP2B4	periodontitis 	MONDO:0005076	periodontitis	dysregulated	RT-qPCR; RNA-seq	circATP2B4 is one of the key circRNAs associated with Redondoviridae-related periodontitis and was included among the five differentially expressed circRNAs validated by qRT-PCR. Specific miRNA or mRNA partners were not detailed in the supplied text.	0.4032
35075668	Journal of medical virology	2022	Redondoviridae infection regulates circRNAome in periodontitis.		circDOCK1	hsa_circ_DOCK1	DOCK1	periodontitis 	MONDO:0005076	periodontitis	dysregulated	RNA-seq	circDOCK1 was identified as one of the key circRNAs associated with Redondoviridae-related periodontitis through RNA-seq and predicted ceRNA network analysis. No qRT-PCR validation or specific interaction partners were detailed for circDOCK1 in the supplied text.	0.348
35075668	Journal of medical virology	2022	Redondoviridae infection regulates circRNAome in periodontitis.		circTTBK2	hsa_circ_TTBK2	TTBK2	periodontitis 	MONDO:0005076	periodontitis	up-regulated	RT-qPCR; RNA-seq	"circTTBK2 is up-regulated in Redondoviridae-positive periodontitis gingival tissues and was validated by qRT-PCR. The study predicts that circTTBK2 may participate in a ceRNA axis, especially circTTBK2-hsa-miR-6749-3p-COL1A1, relevant to Redondoviridae-infected periodontitis."	0.4032
35075668	Journal of medical virology	2022	Redondoviridae infection regulates circRNAome in periodontitis.		circMCTP2	hsa_circ_MCTP2	MCTP2	periodontitis 	MONDO:0005076	periodontitis	up-regulated	RT-qPCR; RNA-seq	circMCTP2 is up-regulated in Redondoviridae-positive periodontitis gingival tissues and was validated by qRT-PCR. The study identifies it as a key circRNA associated with Redondoviridae-related periodontitis through predicted circRNA-miRNA-mRNA network analysis.	0.4032
35076814	Biochemical genetics	2022	Identification of a Novel circ_0010235/miR-1249-3p/HOXA13 Axis in Lung Adenocarcinoma.	hsa_circ_0010235		hsa_circ_ALDH4A1	ALDH4A1	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"circ_0010235 is upregulated in LUAD and acts as an oncogenic circRNA. It promotes proliferation, migration, invasion, EMT, and tumor growth by sponging miR-1249-3p and relieving repression of HOXA13."	0.8708
35076816	Molecular and cellular biochemistry	2022	Circ-LTBP1 is involved in doxorubicin-induced intracellular toxicity in cardiomyocytes via miR-107/ADCY1 signal.	hsa_circ_0053919	circ-LTBP1	hsa_circ_LTBP1	LTBP1	doxorubicin-induced cardiotoxicity 	MONDO:0023006	doxorubicin induced cardiomyopathy	up-regulated	RT-qPCR	"This study found that human circ-LTBP1/hsa_circ_0053919 is up-regulated in DOX-stimulated AC16 cardiomyocyte-like cells and mainly localized in the cytoplasm. Circ-LTBP1 promotes DOX-induced cardiotoxicity-related injury by sponging miR-107 and increasing ADCY1 expression, thereby enhancing proliferation inhibition, inflammation, apoptosis, and oxidative stress. Knockdown of circ-LTBP1 alleviated these DOX-induced toxic effects, suggesting circ-LTBP1 as a potential therapeutic target for DOX-induced cardiotoxicity."	0.7216
35080329	IUBMB life	2022	CircRNA_0040705 promotes the progression of hepatocellular carcinoma.	hsa_circ_0040705	CircRNA_0040705 	hsa_circ_USP10	USP10	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0040705 is up-regulated in HCC tissues and cell lines. It promotes HCC cell proliferation, migration, invasion, EMT-related changes, and lung metastasis by sponging miR-557 and indirectly increasing SOX2 expression."	0.6835
35083632	Journal of molecular histology	2022	"TGF-beta2-induced circ-PRDM5 regulates migration, invasion, and EMT through the miR-92b-3p/COL1A2 pathway in human lens epithelial cells."		circ-PRDM5 	hsa_circ_PRDM5	PRDM5	posterior capsule opacities 	MONDO:0005129	cataract	up-regulated	RT-qPCR	"circ-PRDM5 is up-regulated in PCO tissues and TGF-beta2-stimulated human lens epithelial cells. It promotes LEC viability, migration, invasion, and EMT by acting as a miR-92b-3p sponge to increase COL1A2 expression, suggesting a potential therapeutic role in PCO."	0.7785
35084579	Cardiovascular drugs and therapy	2023	CircCHMP5 Contributes to Ox-LDL-induced Endothelial Cell Injury Through the Regulation of MiR-532-5p/ROCK2 axis.	hsa_circ_0003575	circCHMP5	hsa_circ_CHMP5	CHMP5	atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"circCHMP5/hsa_circ_0003575 is up-regulated in ox-LDL-induced HUVECs and in serum from AS patients. It aggravates endothelial cell injury by sponging miR-532-5p and increasing ROCK2 expression, leading to reduced cell cycle progression, proliferation, and angiogenesis and increased apoptosis, inflammation, and oxidative stress. The study suggests circCHMP5 as a potential therapeutic target for atherosclerosis."	0.8278
35089454	Clinical and experimental medicine	2022	Circular RNA circZCCHC6 contributes to tumorigenesis by regulating LPCAT1 via miR-433-3p in non-small cell lung cancer.		circZCCHC6 	hsa_circ_ZCCHC6	ZCCHC6	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Northern Blot	"circZCCHC6 is up-regulated in NSCLC serum, tissues, and cell lines and shows diagnostic potential. Functionally, it promotes NSCLC cell proliferation, cell cycle progression, migration, invasion, EMT, and xenograft tumor growth. Mechanistically, circZCCHC6 sponges miR-433-3p to positively regulate LPCAT1 expression, forming a circZCCHC6/miR-433-3p/LPCAT1 axis."	0.8324
35091683	Oncogene	2022	CircVPS13C promotes pituitary adenoma growth by decreasing the stability of IFITM1 mRNA via interacting with RRBP1.	hsa_circ_0000607	circVPS13C	hsa_circ_VPS13C	VPS13C	nonfunctioning pituitary adenomas 	MONDO:0019613	non-functioning pituitary adenoma	up-regulated	RT-qPCR; ISH; Microarray	"circVPS13C is a human VPS13C-derived circRNA upregulated in nonfunctioning pituitary adenomas. It promotes NFPA growth and aggressive cellular behaviors by competitively binding RRBP1, reducing IFITM1 mRNA stability/expression, enhancing MAPK signaling, and suppressing apoptosis. Clinically, its high expression is associated with aggressive NFPA features and serum circVPS13C may be useful for diagnosis and follow-up."	0.8585
35091706	Pediatric research	2022	Circ-ITCH overexpression promoted cell proliferation and migration in Hirschsprung disease through miR-146b-5p/RET axis.		circ-ITCH 	hsa_circ_ITCH	ITCH	Hirschsprung disease 	MONDO:0018309	Hirschsprung disease	down-regulated	RT-qPCR	"Circ-ITCH was downregulated in HSCR colon tissues and cells. Its overexpression promoted proliferation and migration of 293T and SH-SY5Y cells by sponging miR-146b-5p, increasing RET expression, and activating the MAPK/ERK pathway, suggesting a potential protective role against HSCR-related cellular defects."	0.6536
35092479	Mammalian genome : official journal of the International Mammalian Genome Society	2022	Circular RNA circMTO1 suppressed the progression of renal cell carcinoma progression by sponging miR-211 and miR-204.	hsa_circ_0007874	circMTO1 	hsa_circ_MTO1	MTO1	renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	down-regulated	RT-qPCR	"circMTO1 is down-regulated in RCC tissues and cell lines and acts as a tumor-suppressive circRNA. It inhibits RCC cell proliferation, migration and invasion while promoting apoptosis, at least partly by sponging miR-211 and miR-204 to regulate KLF6. Clinically, lower circMTO1 expression is associated with advanced Fuhrman grade, advanced TNM stage, and poorer overall survival."	0.7745
35098413	Metabolic brain disease	2022	Circular RNA circSLC8A1 inhibits the proliferation and invasion of glioma cells through targeting the miR-214-5p/CDC27 axis.		circSLC8A1 	hsa_circ_SLC8A1	SLC8A1	glioma	MONDO:0021042	glioma	down-regulated	RT-qPCR	"circSLC8A1 is down-regulated in glioma tissues and glioma cell lines. Functionally, circSLC8A1 suppresses glioma cell proliferation and invasion. Mechanistically, circSLC8A1 sponges miR-214-5p and its tumor-suppressive effects are mediated through the miR-214-5p/CDC27 axis."	0.6479
35099761	Cardiovascular toxicology	2022	"Circ-SWT1 Ameliorates H2O2-Induced Apoptosis, Oxidative Stress and Endoplasmic Reticulum Stress in Cardiomyocytes via miR-192-5p/SOD2 Axis."	hsa_circ_0015677	Circ-SWT1 	hsa_circ_SWT1	SWT1	Acute myocardial infarction 	MONDO:0004781	acute myocardial infarction	down-regulated	RT-qPCR; Microarray	"Circ-SWT1 is down-regulated in AMI blood samples and in H 2 O 2 -stimulated human AC16 cardiomyocytes. Its overexpression protects cardiomyocytes from H 2 O 2 -induced apoptosis, oxidative stress and ER stress by sponging miR-192-5p and derepressing SOD2, suggesting potential therapeutic relevance in AMI."	0.8058
35100091	"Cell cycle (Georgetown, Tex.)"	2022	CircFAM53B promotes the proliferation and metastasis of glioma through activating the c-MET/PI3K/AKT pathway via sponging miR-532-3p.	hsa_circ_0020318	CircFAM53B 	hsa_circ_FAM53B	FAM53B	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circFAM53B is up-regulated in glioma tissues and cell lines, and higher expression predicts poorer patient survival. Functionally, it promotes glioma proliferation, invasion, EMT and in vivo tumor growth while suppressing apoptosis. Mechanistically, circFAM53B sponges miR-532-3p to activate the MET/c-MET-mediated PI3K/AKT pathway."	0.7789
35103833	Archives of gynecology and obstetrics	2022	"Circ_0002577/miR-126-5p/MACC1 axis promotes endometrial carcinoma progression by regulation of proliferation, migration, invasion, and apoptosis of endometrial carcinoma cells."	hsa_circ_0002577	circ_0002577	hsa_circ_WDR26	WDR26	endometrial carcinoma 	MONDO:0002447	endometrial carcinoma	up-regulated	RT-qPCR	"circ_0002577 is upregulated in endometrial carcinoma tissues and cells. It promotes EC progression by enhancing proliferation, migration, invasion and in vivo tumor growth while suppressing apoptosis. Mechanistically, circ_0002577 sponges miR-126-5p to upregulate MACC1 expression."	0.705
35103839	Journal of bone and mineral metabolism	2022	CircTMOD3 promotes lipopolysaccharide-induced chondrocyte apoptosis in osteoarthritis by sponging miR-27a.		circTMOD3 	hsa_circ_TMOD3	TMOD3	osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circTMOD3 is up-regulated in cartilage tissues from OA patients and in LPS-treated chondrocytes. It localizes to both nuclear and cytoplasmic fractions, binds premature miR-27a, suppresses miR-27a maturation, and thereby promotes LPS-induced chondrocyte apoptosis, suggesting a potential role in OA progression and therapy."	0.6432
35104698	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2022	SiRNA-circFARSA-loaded porous silicon nanomaterials for pancreatic cancer treatment via inhibition of CircFARSA expression.		circFARSA 	hsa_circ_FARSA	FARSA	pancreatic cancer	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"circFARSA is up-regulated in pancreatic cancer cell lines and patient-derived pancreatic cancer tumor tissue, supporting its role as a therapeutic target. Silencing circFARSA with siRNA-circFARSA suppresses proliferation, migration, cell-cycle progression and tumor growth, while promoting apoptosis through reduced BCL-2 protein expression and inhibition of BCL-2-related anti-apoptotic signaling. The study develops pSiNP-PEI-siRNA-circFARSA as a safer and more effective delivery system for pancreatic cancer treatment."	0.5445
35113003	"Cell cycle (Georgetown, Tex.)"	2022	Hsa_circ_0001756 promotes ovarian cancer progression through regulating IGF2BP2-mediated RAB5A expression and the EGFR/MAPK signaling pathway.	hsa_circ_0001756				ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"hsa_circ_0001756 is upregulated in ovarian cancer tissues and cell lines. Functionally, it promotes OC cell proliferation, invasion, EMT, and xenograft tumor growth. Mechanistically, hsa_circ_0001756 binds and upregulates IGF2BP2, promoting RAB5A expression and EGFR/MAPK signaling activation."	0.7032
35134495	Genomics	2022	Circ_0004015 silencing represses cisplatin chemoresistance and tumor progression by reducing KLF8 in a miR-198-dependent manner in non-small cell lung cancer.	hsa_circ_0004015	circ_0004015	hsa_circ_CDK14	CDK14	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"Circ_0004015 is upregulated in DDP-resistant NSCLC tissues and cells. It promotes cisplatin resistance and malignant phenotypes by sponging miR-198 and increasing KLF8 expression, while circ_0004015 knockdown sensitizes NSCLC cells and xenograft tumors to DDP."	0.7595
35138580	Molecular biotechnology	2022	Circular RNA Derived from Vacuolar ATPase Assembly Factor VMA21 Suppresses Lipopolysaccharide-Induced Apoptosis of Chondrocytes in Osteoarthritis (OA) by Decreasing Mature miR-103 Production.		Circular RNA derived from vacuolar ATPase assembly factor	hsa_circ_VMA21	VMA21	osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR	"VMA21 is a human circRNA derived from the VMA21 gene and is down-regulated in osteoarthritis articular cartilage. It directly interacts with pre-miR-103, decreases mature miR-103 production, and suppresses LPS-induced apoptosis while increasing viability of CHON-001 chondrocytes. The study suggests that VMA21 has a protective role in OA and may be a potential therapeutic target."	0.6676
35142978	International urology and nephrology	2022	Exosomal circTAOK1 contributes to diabetic kidney disease progression through regulating SMAD3 expression by sponging miR-520h.	hsa_circ_0003928	circTAOK1 	hsa_circ_TAOK1	TAOK1	diabetic kidney disease 	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"Exosomal circTAOK1 is up-regulated in HG-treated GEC-derived exosomes and in serum exosomes from DN patients. It is transferred from GECs to GMCs and promotes GMC proliferation, cell-cycle progression, fibrosis, and EMT through sponging miR-520h and increasing SMAD3 expression. Serum exosomal circTAOK1 also showed potential diagnostic value for DN."	0.774
35145234	Oncogene	2022	CircKDM4B suppresses breast cancer progression via the miR-675/NEDD4L axis.	hsa_circ_0002926	circKDM4B	hsa_circ_KDM4B	KDM4B	breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; RNA-seq	"circKDM4B (hsa_circ_0002926) is down-regulated in breast cancer tissues and functions as a tumor suppressor. It sponges miR-675 to increase NEDD4L, promoting PI3KCA ubiquitination and inhibiting PI3K/AKT signaling, VEGFA secretion, angiogenesis, migration, invasion, tumor growth and metastasis. Its expression shows diagnostic potential for distinguishing tumor from non-tumor tissues and may represent a therapeutic target."	0.8933
35149992	Journal of medical virology	2022	vFLIP-regulated competing endogenous RNA (ceRNA) networks targeting lytic induction for KSHV-associated malignancies.	hsa_circ_0070049				KSHV-associated malignancies 	MONDO:0005055	Kaposi's sarcoma	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0070049 is a vFLIP-regulated circRNA identified by whole-transcriptome sequencing and validated by RT-qPCR in KSHV cell models. The study proposes that hsa_circ_0070049 functions as a ceRNA for hsa-miR-378i to regulate SPEG and FOXQ1, forming a circRNA/miRNA/mRNA network potentially involved in KSHV reactivation and relevant to therapeutic targeting of KSHV-associated malignancies."	0.3858
35166634	Autoimmunity	2022	"Circ_0072008, an oncogene in pancreatic ductal adenocarcinoma, contributes to tumour cell malignant progression and glycolysis by regulating miR-545-3p/SLC7A11 axis."	hsa_circ_0072008	hsa_circRNA_103809	hsa_circ_ZFR	ZFR	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; Microarray	"Circ_0072088/hsa_circRNA_103809 is up-regulated in PDAC tumours and cell lines and its high expression is associated with advanced TNM stage. Functionally, circ_0072088 promotes PDAC cell viability, migration, invasion, tumour growth and glycolysis while suppressing apoptosis. Mechanistically, it acts through the circ_0072088/miR-545-3p/SLC7A11 ceRNA axis."	0.7416
35166635	Autoimmunity	2022	"Circ_0016347 modulates proliferation, migration, invasion, cell cycle, and apoptosis of osteosarcoma cells via the miR-661/IL6R axis."	hsa_circ_0016347		hsa_circ_KCNH1	KCNH1	osteosarcoma	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"Circ_0016347 is up-regulated in human osteosarcoma tissues and cells and acts as an oncogenic circRNA. It promotes proliferation, migration, invasion, cell cycle progression and tumor growth while suppressing apoptosis, at least partly through the miR-661/IL6R axis and activation of JAK2/STAT3 signaling."	0.7662
35171359	International journal of clinical oncology	2022	CircRNA PVT1 promotes proliferation and chemoresistance of osteosarcoma cells via the miR-24-3p/KLF8 axis.			hsa_circ_PVT1	PVT1	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circPVT1 is up-regulated in osteosarcoma tissues, osteosarcoma cell lines, and chemoresistant osteosarcoma cells. It promotes proliferation and resistance to cisplatin, doxorubicin, and methotrexate by sponging miR-24-3p and up-regulating KLF8. Clinically, high circPVT1 expression is associated with adverse clinicopathological features and poorer overall survival."	0.7507
35172669	Immunological investigations	2022	"Circ_0008365 Suppresses Apoptosis, Inflammation and Extracellular Matrix Degradation of IL-1beta-treated Chondrocytes in Osteoarthritis by Regulating miR-324-5p/BMPR2/NF-kappaB Signaling Axis."	hsa_circ_0008365				osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR	"circ_0008365 is downregulated in OA cartilage tissues and IL-1beta-treated human chondrocytes. Its overexpression protects chondrocytes from IL-1beta-induced injury by reducing apoptosis, inflammation and ECM degradation, acting through the miR-324-5p/BMPR2 axis and inhibition of NF-kappaB signaling."	0.7277
35174780	"Cell cycle (Georgetown, Tex.)"	2022	CircPAG1 interacts with miR-211-5p to promote the E2F3 expression and inhibit the high glucose-induced cell apoptosis and oxidative stress in diabetic cataract.	hsa_circ_0006057	circPAG1	hsa_circ_PAG1	PAG1	diabetic cataract 	MONDO:0001687	diabetic cataract	down-regulated	RT-qPCR	"circPAG1 is downregulated in diabetic cataract lens samples and in high glucose-treated human lens epithelial cells. Its overexpression protects lens epithelial cells from high glucose-induced dysfunction by sponging miR-211-5p and increasing E2F3 expression, thereby promoting viability/proliferation and inhibiting apoptosis and oxidative stress. The study proposes circPAG1 as a potential therapeutic biomarker for diabetic cataract."	0.8111
35181843	Biochemical genetics	2022	Circ_0061140 Contributes to the Malignant Progression in Ovarian Cancer Cells by Mediating the RAB1A Level Through Sponging miR-361-5p.	hsa_circ_0061140	circ_0061140 	hsa_circ_C20orf11	C20orf11	Ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"This study identifies circ_0061140 as an up-regulated oncogenic circRNA in ovarian cancer tissues and cells. circ_0061140 promotes proliferation, migration, invasion, EMT, angiogenesis and xenograft tumor growth while suppressing apoptosis, mainly by sponging miR-361-5p to increase RAB1A expression."	0.8175
35185285	Cytotechnology	2022	Exosomal circ_PTPRA inhibits tumorigenesis and promotes radiosensitivity in colorectal cancer by enriching the level of SMAD4 via competitively binding to miR-671-5p.		circ_PTPRA 	hsa_circ_PTPRA	PTPRA	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	circ_PTPRA is downregulated in serum-derived exosomes from CRC patients and in CRC cell lines. Exosomal circ_PTPRA suppresses CRC cell proliferation and tumor growth and enhances radiosensitivity by sponging miR-671-5p to increase SMAD4 expression. The study suggests exosomal circ_PTPRA may serve as a CRC biomarker and therapeutic target.	0.7595
35185288	Cytotechnology	2022	hsa_circ_0000218/hsa-miR-139-3p/SOX4 regulatory feedback circuit influences the proliferation and apoptosis of gastric cancer cells.	hsa_circ_0000218	hsa_circRNA_0000218 			gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"This study reports that hsa_circ_0000218/circ_0000218 is up-regulated in AGS gastric cancer cells compared with GES-1 cells. Functionally, circ_0000218 promotes GC cell proliferation and suppresses apoptosis. Mechanistically, circ_0000218 adsorbs and negatively regulates miR-139-3p, thereby upregulating SOX4 through the circ_0000218/miR-139-3p/SOX4 axis."	0.6207
35187761	Hepatology research : the official journal of the Japan Society of Hepatology	2022	Circ_0011232 contributes to hepatocellular carcinoma progression through miR-503-5p/AKT3 axis.	hsa_circ_0011232	circ_0011232	hsa_circ_PUM1	PUM1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"Circ_0011232 is upregulated in HCC tissues and cells and is associated with poorer overall survival and aggressive clinicopathological features. Functionally, it promotes proliferation, colony formation, migration, invasion, and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ_0011232 sponges miR-503-5p to upregulate AKT3, forming a circ_0011232/miR-503-5p/AKT3 oncogenic axis."	0.8283
35192424	"Cell cycle (Georgetown, Tex.)"	2022	Hsa_circ_0007059 promotes apoptosis and inflammation in cardiomyocytes during ischemia by targeting microRNA-378 and microRNA-383.	hsa_circ_0007059				myocardial infarction 	MONDO:0005068	myocardial infarction	up-regulated	RT-qPCR; Microarray	"This study reports that circ_0007059 is up-regulated in infarcted hearts of MI mouse models and H2O2-treated cardiomyocytes. Functionally, circ_0007059 promotes MI-related cardiomyocyte apoptosis, inflammation and oxidative stress, while its knockdown reduces infarct size and improves cardiac function. Mechanistically, circ_0007059 acts as a ceRNA sponge for miR-378 and miR-383, with miR-378 linked to apoptosis regulation and miR-383 linked to inflammatory responses."	0.6004
35196193	"Cell cycle (Georgetown, Tex.)"	2022	Circ_0020123 promotes NSCLC tumorigenesis via up-regulating KIAA1522 expression through miR-940.	hsa_circ_0020123	Circ_0020123	hsa_circ_PDZD8	PDZD8	non-small cell lung carcinomas 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"Circ_0020123 is up-regulated in NSCLC tissues and cell lines and is associated with more advanced clinicopathological features. It promotes NSCLC cell proliferation, cell cycle progression, migration, invasion and xenograft tumor growth while suppressing apoptosis. Mechanistically, cytoplasmic circ_0020123 acts as a ceRNA for miR-940, thereby increasing KIAA1522 expression through the circ_0020123/miR-940/KIAA1522 axis."	0.8279
35196925	Autoimmunity	2022	Circ_0110251 overexpression alleviates IL-1beta-induced chondrocyte apoptosis and extracellular matrix degradation by regulating miR-3189-3p/SPRY1 axis in osteoarthritis.	hsa_circ_0110251	circ_0110251	hsa_circ_COL11A1	COL11A1	osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR	Circ_0110251 is down-regulated in OA cartilage tissues and IL-1beta-induced chondrocytes. Its overexpression protects chondrocytes by reducing apoptosis and ECM degradation through a circ_0110251/miR-3189-3p/SPRY1 ceRNA axis.	0.8191
35196944	Immunopharmacology and immunotoxicology	2022	Circ_0025033 deficiency suppresses paclitaxel resistance and malignant development of paclitaxel-resistant ovarian cancer cells by modulating the miR-532-3p/FOXM1 network.	hsa_circ_0025033	circ_0025033	hsa_circ_FOXM1	FOXM1	ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circ_0025033 is up-regulated in ovarian cancer tissues and cells, with higher expression in paclitaxel-resistant ovarian cancer cells. Functionally, circ_0025033 promotes PTX resistance, migration, and invasion while suppressing apoptosis, and its knockdown reverses these malignant phenotypes. Mechanistically, circ_0025033 acts as a ceRNA for miR-532-3p to upregulate FOXM1, and circ_0025033-deficient exosomes can also inhibit PTX resistance and malignant behavior."	0.7795
35218724	Experimental cell research	2022	Silencing of circ-CDK14 suppresses osteosarcoma progression through the miR-198/E2F2 axis.	hsa_circ_0001721	circ-CDK14 	hsa_circ_CDK14	CDK14	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ-CDK14 is up-regulated in osteosarcoma tissues and cell lines. Functionally, circ-CDK14 supports OS malignant phenotypes including cell viability, migration, invasion, glycolysis and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ-CDK14 acts as a miR-198 sponge to regulate E2F2 expression, forming a circ-CDK14/miR-198/E2F2 regulatory axis with potential therapeutic relevance."	0.7289
35220873	"Cell cycle (Georgetown, Tex.)"	2022	Circ_0008035 promotes the progression of gastric cancer via the regulation of miR-1256/CEACAM6 axis.	hsa_circ_0008035	circ_0008035	hsa_circ_EXT1	EXT1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circ_0008035 is up-regulated in gastric cancer tissues and cells. It promotes malignant phenotypes and tumor growth by sponging miR-1256 and increasing CEACAM6 expression, indicating a potential therapeutic target for GC."	0.7761
35225430	Environmental toxicology	2022	circ_0089153 exacerbates breast cancer cells proliferation and metastasis via sponging miR-2467-3p/E2F6.	hsa_circ_0089153	circ_0089153			breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circ_0089153 is up-regulated in breast cancer tissues and cell lines, and high expression is associated with poorer long-term survival. Functionally, circ_0089153 promotes proliferation, migration, invasion, EMT, tumor growth and lung metastasis. Mechanistically, it mainly acts as a cytoplasmic sponge for miR-2467-3p, increasing E2F6 expression and driving malignant breast cancer progression."	0.877
35227776	Neuroscience letters	2022	Hsa_circ_0009057 can be a novel potential diagnostic biomarker and a therapeutic target for premature brain injury.	hsa_circ_0009057		hsa_circ_ZCCHC17	ZCCHC17	premature brain injury 	MONDO:0043510	brain injury	up-regulated	RT-qPCR; Microarray	"hsa_circ_0009057 was significantly up-regulated in plasma/peripheral blood of infants with premature brain injury and was validated by RT-qPCR. The study proposes it as a potential diagnostic biomarker and therapeutic target, with ROC AUC 0.795, and predicts a circRNA-miRNA-mRNA regulatory network involving miR_27a_5p, miR_769_3p, miR_450b_3p, miR_335_3p and multiple target mRNAs."	0.5963
35227776	Neuroscience letters	2022	Hsa_circ_0009057 can be a novel potential diagnostic biomarker and a therapeutic target for premature brain injury.	hsa_circ_0001790		hsa_circ_ASH2L	ASH2L	premature brain injury 	MONDO:0043510	brain injury	up-regulated	RT-qPCR; Microarray	hsa_circ_0001790 was identified as an up-regulated circRNA in infants with PBI and was among the circRNAs consistently validated by RT-qPCR after microarray screening. No specific mechanistic or diagnostic analysis was reported for this circRNA.	0.4773
35227776	Neuroscience letters	2022	Hsa_circ_0009057 can be a novel potential diagnostic biomarker and a therapeutic target for premature brain injury.	hsa_circ_0055002		hsa_circ_MEIS1	MEIS1	premature brain injury 	MONDO:0043510	brain injury	up-regulated	RT-qPCR; Microarray	hsa_circ_0055002 was identified as an up-regulated circRNA in infants with PBI and was among the circRNAs consistently validated by RT-qPCR after microarray screening. No specific mechanistic or diagnostic analysis was reported for this circRNA.	0.4773
35227776	Neuroscience letters	2022	Hsa_circ_0009057 can be a novel potential diagnostic biomarker and a therapeutic target for premature brain injury.	hsa_circ_0000133		hsa_circ_ILF2	ILF2	premature brain injury 	MONDO:0043510	brain injury	up-regulated	RT-qPCR; Microarray	hsa_circ_0000133 was identified as an up-regulated circRNA in infants with PBI and was among the circRNAs consistently validated by RT-qPCR after microarray screening. No specific mechanistic or diagnostic analysis was reported for this circRNA.	0.4773
35227776	Neuroscience letters	2022	Hsa_circ_0009057 can be a novel potential diagnostic biomarker and a therapeutic target for premature brain injury.	hsa_circ_0087893		hsa_circ_TMEM245	TMEM245	premature brain injury 	MONDO:0043510	brain injury	down-regulated	RT-qPCR; Microarray	hsa_circ_0087893 was identified as a down-regulated circRNA in infants with PBI and was among the circRNAs consistently validated by RT-qPCR after microarray screening. No specific mechanistic or diagnostic analysis was reported for this circRNA.	0.4773
35230926	"Cell cycle (Georgetown, Tex.)"	2022	"Circ_0085315 promotes cell proliferation, invasion, and migration in colon cancer through miR-1200/MAP3K1 signaling pathway."	hsa_circ_0085315	circRNA_0085315 	hsa_circ_EIF3E	EIF3E	colon cancer 	MONDO:0021063	malignant colon neoplasm	up-regulated	RT-qPCR	"hsa_circ_0085315 is up-regulated in colon cancer tissues and cell lines, and higher expression is associated with poorer survival and lymph node metastasis. Mechanistically, it acts as a ceRNA for miR-1200, relieving repression of MAP3K1 and activating MAPK/ERK signaling. Functionally, circ_0085315 promotes colon cancer cell proliferation, migration, and invasion."	0.8343
35234989	Inflammation research : official journal of the European Histamine Research Society ... [et al.]	2022	Circular RNA circPTK2 modulates migration and invasion via miR-136/NFIB signaling on triple-negative breast cancer cells in vitro.	hsa_circ_0003221	circPTK2 	hsa_circ_PTK2	PTK2	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"circPTK2 is up-regulated in TNBC tissues and cell lines and high expression is associated with poor overall survival. Functionally, circPTK2 promotes TNBC cell viability, proliferation, migration, invasion and EMT. Mechanistically, it acts as a miR-136 sponge to up-regulate NFIB and activate PI3K/AKT signaling, suggesting the circPTK2/miR-136/NFIB axis as a potential biomarker and therapeutic target."	0.8432
35235125	Molecular and cellular biochemistry	2022	CircWHSC1 expedites cervical cancer progression via miR-532-3p/LTBP2 axis.		circWHSC1	hsa_circ_WHSC1	WHSC1	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circWHSC1 is up-regulated in cervical cancer tissues and cell lines, and high circWHSC1 expression is associated with poorer patient survival. Functionally, circWHSC1 promotes cervical cancer proliferation, migration, invasion, tumor growth and lung metastasis while suppressing apoptosis. Mechanistically, circWHSC1 acts as a ceRNA for miR-532-3p to enhance LTBP2 expression, forming the circWHSC1/miR-532-3p/LTBP2 regulatory axis."	0.7795
35238066	Andrologia	2022	Circ_0076305 facilitates prostate cancer development via sponging miR-411-5p and regulating PGK1.	hsa_circ_0076305	circ_0076305	hsa_circ_PGC	PGC	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"Circ_0076305 is up-regulated in prostate cancer tissues and cell lines. It functions as an oncogenic circRNA by sponging miR-411-5p to increase PGK1 expression, thereby promoting proliferation, migration, glycolysis and xenograft tumour growth while inhibiting apoptosis. Its expression showed diagnostic potential for distinguishing PCa tissues from normal tissues."	0.8201
35239064	Journal of mammary gland biology and neoplasia	2022	Circ_0008500 Knockdown Improves Radiosensitivity and Inhibits Tumorigenesis in Breast Cancer Through the miR-758-3p/PFN2 Axis.	hsa_circ_0008500	circ_0008500	hsa_circ_DLG1	DLG1	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"hsa_circ_0008500/circ_0008500 is upregulated in breast cancer tissues and cells and functions as an oncogenic circRNA. Its knockdown suppresses cell viability, proliferation, colony formation and xenograft tumor growth, promotes apoptosis, and enhances radiosensitivity. Mechanistically, circ_0008500 sponges miR-758-3p to regulate PFN2 expression through a circ_0008500/miR-758-3p/PFN2 axis."	0.8442
35240453	Reproductive biology	2022	Circular RNA hsa_circ_0011385 contributes to cervical cancer progression through sequestering miR-149-5p and increasing PRDX6 expression.	hsa_circ_0011385		hsa_circ_EIF3I	EIF3I	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"hsa_circ_0011385 is up-regulated in cervical cancer tissues and cell lines and high expression is associated with poorer overall survival. Functionally, it promotes CC cell proliferation, migration, invasion, angiogenesis, and xenograft tumor growth while suppressing apoptosis. Mechanistically, cytoplasmic hsa_circ_0011385 sponges miR-149-5p to increase PRDX6 expression, forming a hsa_circ_0011385/miR-149-5p/PRDX6 regulatory axis."	0.849
35266112	Science China. Life sciences	2022	rtcisE2F promotes the self-renewal and metastasis of liver tumor-initiating cells via N6-methyladenosine-dependent E2F3/E2F6 mRNA stability.		rtcisE2F 			liver cancer 	MONDO:0002691	liver cancer	up-regulated	RT-qPCR; Northern Blot; ISH	"rtcisE2F is a read-through circRNA up-regulated in liver cancer, especially advanced HCC and CD133+ liver TICs. It promotes liver TIC self-renewal, tumor initiation and metastasis by scaffolding IGF2BP2 to E2F6/E2F3 mRNAs, preventing YTHDF2-mediated decay, stabilizing E2F6/E2F3 transcripts and activating Wnt/beta-catenin signaling. Its high expression is associated with relapse and poor prognosis, suggesting diagnostic, prognostic and therapeutic relevance."	0.8686
35274224	Journal of bioenergetics and biomembranes	2022	"Circ-LRP1B functions as a competing endogenous RNA to regulate proliferation, apoptosis and oxidative stress of LPS-induced human C28/I2 chondrocytes."	hsa_circ_0056650	circ-LRP1B	hsa_circ_LRP1B	LRP1B	osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR	"Circ-LRP1B is down-regulated in OA cartilage and LPS-stimulated human C28/I2 chondrocytes. Its enforced expression protects chondrocytes from LPS-induced injury by promoting proliferation, suppressing apoptosis and oxidative stress, and modulating OA-related inflammatory and matrix markers. Mechanistically, circ-LRP1B functions as a ceRNA that sponges miR-34a-5p to upregulate NRF1."	0.8275
35274779	Journal of clinical laboratory analysis	2022	hsa_circ_0119412 overexpression promotes cervical cancer progression by targeting miR-217 to upregulate anterior gradient 2.	hsa_circ_0119412	circ_0119412 			cervical cancer	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"hsa_circ_0119412/circ_0119412 is up-regulated in cervical cancer tissues and cell lines. It promotes cervical cancer cell proliferation, migration, adhesion and xenograft tumor growth by sequestering miR-217 and relieving inhibition of AGR2. The study suggests that targeting circ_0119412 may have therapeutic potential in cervical cancer."	0.7795
35277867	Drug development research	2022	"Circ-OPHN1 suppresses the proliferation, migration, and invasion of trophoblast cells through mediating miR-558/THBS2 axis."	hsa_circ_0007445	 circ-OPHN1	hsa_circ_OPHN1	OPHN1	Preeclampsia 	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR	"Circ-OPHN1 is up-regulated in PE placental tissues and is mainly localized in the cytoplasm of trophoblast cells. Functionally, circ-OPHN1 suppresses trophoblast cell proliferation, migration, and invasion and promotes apoptosis. Mechanistically, it sponges miR-558 to increase THBS2 expression, forming a circ-OPHN1/miR-558/THBS2 ceRNA axis implicated in PE pathogenesis."	0.7416
35278480	Brain research	2022	Circ_0002945 functions as a competing endogenous RNA to promote Abeta25-35-induced endoplasmic reticulum stress and apoptosis in SK-N-SH cells and human primary neurons.	hsa_circ_0002945	circ_0002945	hsa_circ_AXL	AXL	Alzheimer's disease 	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR	circ_0002945 is upregulated in AD serum and Abeta25-35-stimulated SK-N-SH cells and human primary neurons. It promotes Abeta-induced neuronal apoptosis and endoplasmic reticulum stress through a ceRNA mechanism in which circ_0002945 binds miR-431-5p and thereby increases TNFAIP1 expression. Its serum upregulation suggests potential clinical relevance for AD detection or risk prediction.	0.8391
35279761	Biochemical genetics	2022	Circ-TFF1 Promotes Breast Cancer Progression Through the miR-129-2-3p/IRAK1 Axis.	hsa_circ_0061825	circ-TFF1 	hsa_circ_TFF1	TFF1	Breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ-TFF1 is up-regulated in breast cancer tissues and cell lines and is mainly cytoplasmic. It promotes malignant breast cancer phenotypes, including proliferation, migration, invasion, angiogenesis/tube formation, and xenograft tumor growth, while suppressing apoptosis. Mechanistically, circ-TFF1 sponges miR-129-2-3p to up-regulate IRAK1, forming a circ-TFF1/miR-129-2-3p/IRAK1 regulatory axis."	0.8175
35284960	Archives of gynecology and obstetrics	2022	"Circ_0062558 promotes growth, migration, and glutamine metabolism in triple-negative breast cancer by targeting the miR-876-3p/SLC1A5 axis."	hsa_circ_0062558	circ_0062558	hsa_circ_MMP11	MMP11	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"circ_0062558 is up-regulated in TNBC tissues and cells and acts as an oncogenic circRNA. It promotes proliferation, survival, migration, invasion, glutamine metabolism, and xenograft tumor growth by sponging miR-876-3p and increasing SLC1A5 expression, suggesting potential therapeutic relevance."	0.8443
35285372	Current eye research	2022	Circ_0075804 Regulates the Expression of LASP1 by Targeting miR-1287-5p and Thus Affects the Biological Process of Retinoblastoma.	hsa_circ_0075804	Circ_0075804 	hsa_circ_E2F3	E2F3	retinoblastoma 	MONDO:0008380	retinoblastoma	up-regulated	RT-qPCR	"Circ_0075804 is up-regulated in retinoblastoma tissues and cell lines and shows diagnostic potential. Functionally, circ_0075804 promotes RB cell proliferation, survival and invasion and supports xenograft tumor growth. Mechanistically, it targets miR-1287-5p to increase LASP1 expression, forming a circ_0075804/miR-1287-5p/LASP1 regulatory axis."	0.7892
35285410	"Cell cycle (Georgetown, Tex.)"	2022	KLF2-induced circZKSCAN1 potentiates the tumorigenic properties of clear cell renal cell carcinoma by targeting the miR-1294/PIM1 axis.		circZKSCAN1	hsa_circ_ZKSCAN1	ZKSCAN1	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR	"circZKSCAN1 is up-regulated in ccRCC tissues and cells and functions as an oncogenic circRNA. Its knockdown suppresses proliferation, migration, invasion, EMT and xenograft tumor growth, while enhancing NK cell-mediated cytotoxicity against RCC cells. Mechanistically, KLF2 transcriptionally regulates circZKSCAN1, which sponges miR-1294 to regulate PIM1 expression."	0.8344
35288970	Experimental dermatology	2022	CircEIF5 contributes to hyperproliferation and inflammation of keratinocytes in psoriasis via p-NFkappaB and p-STAT3 signalling pathway.	hsa_circ_0033469	circEIF5 	hsa_circ_EIF5	EIF5	psoriasis 	MONDO:0005083	psoriasis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0033469/circEIF5 is upregulated in psoriatic skin lesions and in an M5-stimulated HaCaT psoriasis-like model. Functionally, circEIF5 promotes keratinocyte proliferation, G1/S cell-cycle progression, and secretion of inflammatory chemokines. Mechanistically, these effects are mediated through activation of NF-kappaB and STAT3 signalling pathways, suggesting circEIF5 as a potential therapeutic target in psoriasis."	0.7441
35288979	Journal of gastroenterology and hepatology	2022	Circ_0014130 is involved in the drug sensitivity of colorectal cancer through miR-197-3p/PFKFB3 axis.	hsa_circ_0014130	circ_0014130 			colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0014130 is up-regulated in colorectal cancer tissues and cells, especially in 5-FU-resistant samples. It promotes CRC cell proliferation, migration, invasion, glycolytic activity, tumor growth, and 5-FU resistance while suppressing apoptosis. Mechanistically, circ_0014130 sponges miR-197-3p and positively regulates PFKFB3 within the circ_0014130/miR-197-3p/PFKFB3 axis."	0.705
35289739	"Journal of chemotherapy (Florence, Italy)"	2023	Circ_0048856 competes with ABCC1 for miR-193a-5p/miR-98-5p binding sites to promote the cisplatin resistance and tumorigenesis in lung cancer.	hsa_circ_0048856	circ_0048856	hsa_circ_C3	C3	lung cancer 	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circ_0048856 is up-regulated in DDP-resistant lung cancer tissues and cells. It promotes cisplatin resistance, proliferation, invasion and tumor growth while inhibiting apoptosis, mainly by sponging miR-193a-5p and miR-98-5p to regulate ABCC1. Knockdown of circ_0048856 restores DDP sensitivity and suppresses tumorigenesis in vitro and in a xenograft model."	0.8174
35293807	Autoimmunity	2022	Circ_0060531 knockdown ameliorates IL-22-induced keratinocyte damage by binding to miR-330-5p to decrease GAB1 expression.	hsa_circ_0060531	circ_0060531	hsa_circ_PI3	PI3	psoriasis	MONDO:0005083	psoriasis	up-regulated	RT-qPCR	"circ_0060531 is upregulated in psoriatic skin biopsies and IL-22-stimulated HaCaT cells. Its knockdown suppresses IL-22-induced keratinocyte proliferation, migration and inflammatory cytokine production. Mechanistically, circ_0060531 acts as a miR-330-5p sponge to increase GAB1 expression, forming a circ_0060531/miR-330-5p/GAB1 regulatory axis in psoriasis-related keratinocyte dysfunction."	0.8275
35301686	Human cell	2022	Circular RNA circ-PLCD1 functions as a tumor suppressor in non-small cell lung cancer by inactivation of PI3K/AKT signaling pathway.		circ-PLCD1	hsa_circ_PLCD1	PLCD1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	"circ-PLCD1 is a p53-activated tumor-suppressive circRNA that is downregulated in NSCLC tissues and cell lines. It localizes mainly in the cytoplasm and functions as a ceRNA for miR-375 and miR-1179, increasing PTEN and suppressing PI3K/AKT signaling. Higher circ-PLCD1 expression is associated with longer survival, while restoration of circ-PLCD1 inhibits NSCLC proliferation, invasion, tumor growth and metastasis and promotes apoptosis."	0.887
35303684	Biochemical and biophysical research communications	2022	Circular RNA circRNF169 functions as a miR-30c-5p sponge to promote cellular senescence.	mmu_circ_0001605	circRNF169	mmu_circ_RNF169	RNF169	cellular senescence 			up-regulated	RT-qPCR; RNA-seq	"circRNF169/mmu_circ_0001605 is up-regulated in replicative senescent mouse embryonic fibroblasts. Functional experiments showed that circRNF169 promotes cellular senescence and suppresses proliferation, at least partly by acting as a cytoplasmic sponge for miR-30c-5p. The study suggests circRNF169 as a potential target for aging intervention."	0.7442
35305058	Environmental toxicology	2022	"circ_0008797 attenuates non-small cell lung cancer proliferation, metastasis, and aerobic glycolysis by sponging miR-301a-3p/SOCS2."	hsa_circ_0008797	circ_0008797	hsa_circ_GSK3beta	GSK3beta	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"circ_0008797 is down-regulated in NSCLC tissues and cell lines, and higher expression is associated with better overall survival. Functionally, circ_0008797 suppresses proliferation, migration, invasion, glycolysis, tumor growth and metastasis while promoting apoptosis. Mechanistically, it acts as a cytoplasmic miR-301a-3p sponge to increase SOCS2 expression."	0.8712
35307784	Inflammation	2022	CircOAS3 Regulates Keratinocyte Proliferation and Psoriatic Inflammation by Interacting with Hsc70 via the JNK/STAT3/NF-kappaB Signaling Pathway.	hsa_circ_0028434	circOAS3 	hsa_circ_OAS3	OAS3	psoriasis 	MONDO:0005083	psoriasis	up-regulated	RT-qPCR; Microarray	"circOAS3 (hsa_circ_0028434), derived from OAS3, is up-regulated in psoriatic tissues and M5-induced keratinocytes. It promotes keratinocyte proliferation, cell-cycle progression, and inflammatory IL-6 production while inhibiting apoptosis by directly interacting with Hsc70 and activating the JNK/STAT3/NF-kappaB signaling pathway. The study suggests circOAS3 as a potential therapeutic target and biomarker for psoriasis."	0.8386
35314912	Biochemical genetics	2022	Circ_0101802 Facilitates Colorectal Cancer Progression Depending on the Regulation of miR-665/DVL3 Signaling.	hsa_circ_0101802		hsa_circ_PNN	PNN	Colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"Circ_0101802 is up-regulated in colorectal cancer tissues and cell lines and high expression predicts poor survival. Functionally, circ_0101802 promotes CRC proliferation, migration, angiogenesis/tube formation and xenograft tumor growth while suppressing apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-665 to increase DVL3 protein expression."	0.8466
35322289	Journal of bioenergetics and biomembranes	2022	Circ_0001093 promotes glutamine metabolism and cancer progression of esophageal squamous cell carcinoma by targeting miR-579-3p/glutaminase axis.	hsa_circ_0001093	circ_0001093	hsa_circ_ALS2	ALS2	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"hsa_circ_0001093/circ_0001093 is up-regulated in ESCC tissues and cell lines, and high expression is associated with poorer overall survival and adverse clinicopathologic features. Functionally, it promotes ESCC cell proliferation, invasion, migration and glutamine metabolism. Mechanistically, circ_0001093 acts as a ceRNA for miR-579-3p to increase GLS expression, forming a circ_0001093/miR-579-3p/GLS axis."	0.7713
35333985	Journal of bone and mineral metabolism	2022	Regulation of circADAMTS6-miR-324-5p-PIK3R3 ceRNA pathway may be a novel mechanism of IL-1beta-induced osteoarthritic chondrocytes.	hsa_circ_0008667	circADAMTS6 	hsa_circ_ADAMTS6	ADAMTS6	osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR	"circADAMTS6 is downregulated in osteoarthritic cartilage and IL-1beta-induced human chondrocytes. Restoring circADAMTS6 protects chondrocytes by enhancing proliferation and ECM synthesis while reducing apoptosis and inflammation. Mechanistically, circADAMTS6 sponges miR-324-5p to regulate PIK3R3 and suppress activation of the PI3K/AKT/mTOR pathway."	0.8107
35334040	Metabolic brain disease	2022	Circ_RPPH1 regulates glioma cell malignancy by binding to miR-627-5p/miR-663a to induce SDC1 expression.	hsa_circ_0000520	circ_0000520 	hsa_circ_RPPH1	RPPH1	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; Microarray	"circ_RPPH1 is up-regulated in glioma tissues and glioma cell lines. It promotes glioma cell proliferation, migration, invasion and in vivo tumor growth while suppressing apoptosis. Mechanistically, circ_RPPH1 acts through a miR-627-5p/miR-663a/SDC1 regulatory axis, suggesting a potential therapeutic target for glioma."	0.7663
35334414	Biochemical and biophysical research communications	2022	Circular RNA circ_0047744 suppresses the metastasis of pancreatic ductal adenocarcinoma by regulating the miR-21/SOCS5 axis.	hsa_circ_0047744	circ_0047744 	hsa_circ_WDR7	WDR7	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	down-regulated	RT-qPCR; ISH	"circ_0047744 is a WDR7-derived circular RNA that is down-regulated in PDAC tissues and cell lines. It suppresses PDAC migration, invasion and liver metastasis by sponging miR-21 and regulating SOCS5 expression. Clinically, low circ_0047744 expression is associated with lymph node metastasis and worse overall survival, suggesting a tumor-suppressive and potential therapeutic role."	0.8607
35338913	Reproductive biology	2022	CircRNA circ_0043533 facilitates cell growth in polycystic ovary syndrome by targeting miR-1179.	hsa_circ_0043533	circ_0043533			polycystic ovary syndrome 	MONDO:0008487	polycystic ovary syndrome	up-regulated	RT-qPCR	"circ_0043533 is up-regulated in ovarian granulosa cells and is further induced by insulin treatment. Functionally, circ_0043533 promotes viability and proliferation and suppresses apoptosis in insulin-treated COV434 and KGN cells. Mechanistically, it acts as a sponge for miR-1179, and miR-1179 inhibition reverses the effects of circ_0043533 knockdown."	0.6253
35352283	Molecular biotechnology	2022	The Circular RNA circSKA3 Facilitates the Malignant Biological Behaviors of Medulloblastoma via miR-520 h/CDK6 Pathway.		circSKA3 	hsa_circ_SKA3	SKA3	medulloblastoma	MONDO:0007959	medulloblastoma	up-regulated	RT-qPCR	"circSKA3 is up-regulated in medulloblastoma tissues and functions as an oncogenic circRNA. It promotes medulloblastoma cell proliferation, migration, invasion, and cell cycle progression by sponging miR-520 h and regulating CDK6 expression, suggesting the circSKA3/miR-520 h/CDK6 axis as a potential therapeutic target."	0.6521
35352610	Autoimmunity	2022	Circ_0088036 facilitates the proliferation and inflammation and inhibits the apoptosis of fibroblast-like synoviocytes through targeting miR-326/FZD4 axis in rheumatoid arthritis.	hsa_circ_0088036	circ_0088036	hsa_circ_SUSD1	SUSD1	rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"circ_0088036 is up-regulated in synovial tissues from RA patients and in TNF-a-treated RA-FLSs. It promotes RA-FLS proliferation, cell cycle progression and inflammatory cytokine production while inhibiting apoptosis, partly by sponging miR-326 to increase FZD4 expression. Its expression correlates positively with DAS28-ESR, suggesting relevance to RA disease activity."	0.7795
35353360	Molecular biotechnology	2022	Circular RNA has Circ 001372-Reduced Inflammation in Ovalbumin-Induced Asthma Through Sirt1/NFAT5 Signaling Pathway by miRNA-128-3p.		circ 001372			ovalbumin-induced asthma 	MONDO:0004979	asthma	down-regulated	RT-qPCR; Microarray	"circ 001372 was decreased in serum from an ovalbumin-induced asthma mouse model. Functional experiments indicate that circ 001372 acts as an anti-inflammatory circRNA: its overexpression reduces inflammatory cytokine/PGE-2 levels, while its down-regulation enhances inflammation. Mechanistically, the study links circ 001372 to miRNA-128-3p and the Sirt1/NFAT5 signaling pathway."	0.5979
35355231	"Reproductive sciences (Thousand Oaks, Calif.)"	2022	Circ_0000263 facilitates the proliferation and inhibits the apoptosis of cervical cancer depending on the regulation of miR-1179/ABL2 axis.	hsa_circ_0000263	circ_0000263			cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ_0000263 is up-regulated in cervical cancer tissues and cells and is associated with more advanced clinical features. Functionally, circ_0000263 promotes proliferation and tumor growth while inhibiting apoptosis. Mechanistically, cytoplasmic circ_0000263 sponges miR-1179 to up-regulate ABL2, forming a circ_0000263/miR-1179/ABL2 oncogenic axis."	0.7373
35357059	The journal of gene medicine	2022	Circ_0008717 promotes renal cell carcinoma progression by upregulating FBXO17 via targeting miR-217.	hsa_circ_0008717	circ_0008717	hsa_circ_ABCB10	ABCB10	Renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR	"Circ_0008717 is upregulated in RCC tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation, migration, invasion, glycolysis and in vivo tumor growth while inhibiting apoptosis, at least partly through the miR-217/FBXO17 regulatory axis. Clinically, higher circ_0008717 expression is associated with advanced TNM stage, lymph node metastasis and poorer survival."	0.8592
35358709	Transplant immunology	2022	"Circular RNA circ_0130438 suppresses TNF-alpha-induced proliferation, migration, invasion and inflammation in human fibroblast-like MH7A synoviocytes by regulating miR-130a-3p/KLF9 axis."	hsa_circ_0130438	circ_0130438 	hsa_circ_KPNA5	KPNA5	rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	down-regulated	RT-qPCR	"circ_0130438 is down-regulated in RA synovial tissues, RA-FLSs, and TNF-alpha-stimulated MH7A cells. Functionally, circ_0130438 suppresses TNF-alpha-induced proliferation, migration, invasion, and inflammatory cytokine production, partly through a circ_0130438/miR-130a-3p/KLF9 ceRNA mechanism. The study suggests circ_0130438 may have diagnostic biomarker potential in RA."	0.7945
35362879	Biochemical genetics	2022	circ3323 Motivates Host Gene to Promote the Aggressiveness of Bladder Cancer.	hsa_circ_0003323	circ3323 	hsa_circ_APP	APP	Bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"circ3323/hsa_circ_0003323 is an APP-derived human circRNA that is upregulated in bladder cancer tissues and cell lines and mainly localized in the cytoplasm. It promotes bladder cancer proliferation, migration, invasion and metastasis by sponging miR-186-5p/miR-185-5p to increase APP/mAPP expression. Clinically, higher circ3323 expression is associated with worse overall survival, suggesting prognostic biomarker potential."	0.8356
35369902	Journal of pharmacological sciences	2022	"Circular RNA circPSAP functions as an efficient miR-331-3p sponge to regulate proliferation, apoptosis and bortezomib sensitivity of human multiple myeloma cells by upregulating HDAC4."	hsa_circ_0018722	circPSAP 	hsa_circ_PSAP	PSAP	multiple myeloma 	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR; Microarray	"CircPSAP (hsa_circ_0018722), derived from PSAP, is upregulated in human multiple myeloma bone marrow specimens and MM cell lines. It promotes proliferation and cell cycle progression, suppresses apoptosis, and reduces bortezomib sensitivity by functioning as a miR-331-3p sponge that increases HDAC4 expression. High circPSAP expression is associated with advanced clinical stage and poor patient survival."	0.848
35378401	Ecotoxicology and environmental safety	2022	Peripheral blood circular RNA hsa_circ_0058493 as a potential novel biomarker for silicosis and idiopathic pulmonary fibrosis.	hsa_circ_0058493	hsa_-circ_0058493 	hsa_circ_RHBDD1	RHBDD1	silicosis	MONDO:0005960	silicosis	up-regulated	RT-qPCR; RNA-seq; Microarray	"hsa_circ_0058493 is up-regulated in peripheral blood-related samples from silicosis and IPF patients and shows diagnostic biomarker potential for both diseases. In TGF-beta1-treated MRC-5 lung fibroblasts, its expression increases, while siRNA-mediated knockdown reduces fibrotic molecule expression and affects EMT-related markers. The paper further predicts that hsa_circ_0058493 may function through a ceRNA-like mechanism involving miR-3175/miR-2278 and downstream fibrosis-related pathways, although this mechanism was not experimentally confirmed."	0.7586
35378401	Ecotoxicology and environmental safety	2022	Peripheral blood circular RNA hsa_circ_0058493 as a potential novel biomarker for silicosis and idiopathic pulmonary fibrosis.	hsa_circ_0058493	hsa_-circ_0058493 	hsa_circ_RHBDD1	RHBDD1	idiopathic pulmonary fibrosis 	MONDO:0800504	idiopathic pulmonary fibrosis	up-regulated	RT-qPCR; RNA-seq; Microarray	"hsa_circ_0058493 is up-regulated in peripheral blood-related samples from silicosis and IPF patients and shows diagnostic biomarker potential for both diseases. In TGF-beta1-treated MRC-5 lung fibroblasts, its expression increases, while siRNA-mediated knockdown reduces fibrotic molecule expression and affects EMT-related markers. The paper further predicts that hsa_circ_0058493 may function through a ceRNA-like mechanism involving miR-3175/miR-2278 and downstream fibrosis-related pathways, although this mechanism was not experimentally confirmed."	0.7586
35380509	"Journal of chemotherapy (Florence, Italy)"	2023	Circ_0007841 knockdown confers cisplatin sensitivity to ovarian cancer cells by down-regulation of NFIB expression in a miR-532-5p-dependent manner.	hsa_circ_0007841	circular RNA_0007841 			ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"Circ_0007841 is upregulated in DDP-resistant ovarian cancer tissues and cells. It promotes cisplatin resistance and malignant phenotypes by sponging miR-532-5p to increase NFIB expression, while its knockdown improves DDP sensitivity, suppresses proliferation, migration and invasion, and induces apoptosis. The study also indicates that circ_0007841 can be packaged into exosomes and may serve as a therapeutic target for DDP-resistant ovarian cancer."	0.7662
35390562	Environment international	2022	A study on the roles of long non-coding RNA and circular RNA in the pulmonary injuries induced by polystyrene microplastics.		circRNA 014924			pulmonary injuries induced by polystyrene microplastics 	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR; RNA-seq	"circRNA 014924 was significantly up-regulated in lung tissues of SD rats exposed to high-dose 100 nm PS-MPs and was validated by qRT-PCR. The study suggests it may participate in PS-MPs-induced lung inflammation and adverse lung effects, although its specific molecular mechanism was not defined."	0.3684
35390562	Environment international	2022	A study on the roles of long non-coding RNA and circular RNA in the pulmonary injuries induced by polystyrene microplastics.		circRNA 006603			pulmonary injuries induced by polystyrene microplastics 	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR; RNA-seq	"circRNA 006603 was significantly up-regulated in lung tissues of SD rats exposed to high-dose 100 nm PS-MPs and was validated by qRT-PCR. The study suggests it may participate in PS-MPs-induced lung inflammation and adverse lung effects, although its specific molecular mechanism was not defined."	0.3684
35390562	Environment international	2022	A study on the roles of long non-coding RNA and circular RNA in the pulmonary injuries induced by polystyrene microplastics.		circ003982 			pulmonary injuries induced by polystyrene microplastics 	MONDO:0015796	acute lung injury	down-regulated	RT-qPCR; RNA-seq	"circ003982/circRNA 003982/circ 003982 was significantly down-regulated in lung tissues of SD rats exposed to 100 nm PS-MPs, showing a dose-dependent downward trend by qRT-PCR. The study suggests it may participate in PS-MPs-induced lung inflammation and adverse lung effects, although its specific molecular mechanism was not defined."	0.3684
35390631	"Pathology, research and practice"	2022	Identification and function of circular RNA hsa_circ_0071106: A novel biomarker for differentiation degree of esophageal squamous cell carcinoma.	hsa_circ_0071106	hsa_-circ_0071106	hsa_circ_ARHGAP10	ARHGAP10	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0071106 is a human circRNA derived from ARHGAP10 that is downregulated in ESCC tissues and cell lines. Low expression is associated with poorer histological differentiation, and functional knockdown experiments indicate a tumor-suppressive role, mainly restraining ESCC cell migration and invasion, with transient effects on proliferation and apoptosis. The circRNA may serve as a diagnostic biomarker and a predictor of ESCC differentiation degree."	0.7969
35391605	General thoracic and cardiovascular surgery	2022	Circular RNA circ_0001445 alleviates the ox-LDL-induced endothelial injury in human primary aortic endothelial cells through regulating ABCG1 via acting as a sponge of miR-208b-5p.	hsa_circ_0001445	circ_0001445 	hsa_circ_SMARCA5	SMARCA5	Coronary artery disease 	MONDO:0005010	coronary artery disorder	down-regulated	RT-qPCR	"circ_0001445 is a SMARCA5-derived human circRNA that is downregulated in CAD patient serum and ox-LDL-treated HAECs. Its overexpression protects HAECs from ox-LDL-induced endothelial injury by enhancing proliferation and migration and reducing inflammation and ECM accumulation, acting through the miR-208b-5p/ABCG1 axis. The study also suggests circ_0001445 has diagnostic potential for CAD."	0.8166
35391656	Biochemical genetics	2022	Downregulation of Circ-CEP128 Enhances the Paclitaxel Sensitivity of Cervical Cancer Through Regulating miR-432-5p/MCL1.	hsa_circ_0032815	circ-CEP128 	hsa_circ_CEP128	CEP128	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ-CEP128 is up-regulated in cervical cancer tissues and cells, especially in paclitaxel-resistant CC cells. It promotes paclitaxel resistance and malignant phenotypes by sponging miR-432-5p to up-regulate MCL1, while circ-CEP128 knockdown enhances paclitaxel sensitivity and suppresses tumor growth."	0.7949
35392747	Current eye research	2022	"Interfering Hsa_circRNA_0060640 Suppresses TGF-beta2-Induced Proliferation, Motility and EMT in Human Lens Epithelium Cells by Targeting miR-214-3p and Collagen Type I alpha2 Chain."	hsa_circ_0060640	hsa_circRNA_0060640 	hsa_circ_SULF2	SULF2	posterior capsule opacification 	MONDO:0005129	cataract	up-regulated	RT-qPCR	"Circ_0060640 is up-regulated in anterior lens capsule tissues from PCO/cataractous eyes and in TGF-b2-stimulated SRA01/04 human lens epithelial cells. It promotes TGF-b2-induced proliferation, migration, invasion and EMT, while circ_0060640 knockdown suppresses these pathogenic phenotypes. Mechanistically, cytoplasmic circ_0060640 acts through a circ_0060640/miR-214-3p/COL1A2 ceRNA axis and may represent a therapeutic target for PCO development."	0.7404
35394175	Mammalian genome : official journal of the International Mammalian Genome Society	2022	Circ_0000442 functions as a tumor repressor in breast cancer by impacting miR-1229-3p and upregulating ZBTB1.	hsa_circ_0000442	Circ_0000442			breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	"Circ_0000442 is down-regulated in breast cancer tissues and cell lines and mainly localizes to the cytoplasm. It suppresses breast cancer progression by sponging miR-1229-3p, increasing ZBTB1 expression, inhibiting proliferation, migration, invasion and glycolysis, promoting apoptosis, and reducing xenograft tumor growth."	0.7373
35394558	Neurotoxicity research	2022	Hsa_circ_0008344 Promotes Glioma Tumor Progression and Angiogenesis Presumably by Regulating miR-638/SZRD1 Pathway.	hsa_circ_0008344	hsa_circRNA_0008344 	hsa_circ_UBAP2	UBAP2	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR	"Hsa_circ_0008344/circ_0008344 is up-regulated in glioma tissues and glioma cell lines and mainly localized in the cytoplasm. Functionally, it promotes glioma proliferation, migration, invasion, angiogenesis and xenograft tumor growth while suppressing apoptosis. Mechanistically, it acts as a ceRNA sponge for miR-638 to regulate SZRD1 expression, suggesting potential therapeutic relevance in glioma."	0.8175
35397054	Biochemical genetics	2022	CirRNA circFAM126A Exerts Oncogenic Functions in NSCLC to Upregulate IRS2.		circFAM126A	hsa_circ_FAM126A	FAM126A	Non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circFAM126A is up-regulated in NSCLC tissues and cells and high expression is associated with poorer survival. Functionally, circFAM126A acts as an oncogenic circRNA that promotes proliferation, migration, invasion, cell cycle progression, EMT-related marker changes and xenograft tumor growth while suppressing apoptosis. Mechanistically, it sponges miR-613 to upregulate IRS2, forming a circFAM126A/miR-613/IRS2 regulatory axis."	0.8712
35398178	Neuroscience	2022	CircPOLR2A Promotes Proliferation and Impedes Apoptosis of Glioblastoma Multiforme Cells by Up-regulating POU3F2 to Facilitate SOX9 Transcription.		hsa_circRNA_092437 	hsa_circ_POLR2A	POLR2A	Glioblastoma multiforme 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; Microarray	"circPOLR2A is up-regulated in GBM cell lines and mainly localizes in the cytoplasm. It promotes GBM cell proliferation and suppresses apoptosis by sponging miR-2113, increasing POU3F2 expression, and thereby facilitating POU3F2-mediated SOX9 transcription."	0.7541
35401845	Cellular and molecular bioengineering	2022	"Sevoflurane Suppresses the Proliferation, Migration and Invasion of Colorectal Cancer Through Regulating Circ_0000423/miR-525-5p/SGPP1 Network."	hsa_circ_0000423	circ_0000423	hsa_circ_PPP1R12A	PPP1R12A	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0000423 is upregulated in colorectal cancer tissues and cells and is reduced by sevoflurane treatment. Functionally, circ_0000423 promotes CRC proliferation, migration, invasion and tumor growth while suppressing apoptosis, mainly through the circ_0000423/miR-525-5p/SGPP1 ceRNA axis. Overexpression of circ_0000423 weakens the anti-tumor effects of sevoflurane, suggesting its potential relevance as a therapeutic target in CRC."	0.8005
35413218	"Hematology (Amsterdam, Netherlands)"	2022	Circ_KCNQ5 participates in the progression of childhood acute myeloid leukemia by enhancing the expression of RAB10 via binding to miR-622.	hsa_circ_0004136	circ_0004136 	hsa_circ_KCNQ5	KCNQ5	Acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"circ_KCNQ5 is up-regulated in childhood AML bone marrow samples and AML cell lines. Functionally, circ_KCNQ5 promotes AML cell proliferation and survival while suppressing apoptosis. Mechanistically, it binds miR-622 and enhances RAB10 expression through a circ_KCNQ5/miR-622/RAB10 regulatory axis."	0.7795
35413277	Brain research	2022	CircDYM ameliorates CUMS mice depressive-like behavior and inhibits hippocampal neurons injury via miR-497a-5p/NR3C1 axis.		circDYM 			depression 	MONDO:0002050	depressive disorder	down-regulated	RT-qPCR	"circDYM is downregulated in hippocampus tissues of CUMS depression-model mice. Its overexpression alleviates depressive-like behaviors and suppresses hippocampal neuron injury by sponging miR-497a-5p and increasing NR3C1 expression, thereby promoting neuronal viability and inhibiting apoptosis and inflammation."	0.6578
35414334	"Cell cycle (Georgetown, Tex.)"	2022	Down-regulated Circ_0000190 promotes cervical cancer by facilitating the activity of proto-oncogene protein EIF4E.	hsa_circ_0000190	circ_0000190			cervical cancer 	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR	"circ_0000190 is down-regulated in cervical cancer cells and functions as a tumor suppressor. Its overexpression inhibits proliferation, migration, invasion and xenograft tumor growth while promoting apoptosis. Mechanistically, circ_0000190 sponges miR-1252-5p to up-regulate EIF4EBP2, which suppresses eIF4E activity."	0.6873
35416616	Journal of molecular neuroscience : MN	2022	CircRFX3 Up-regulates Its Host Gene RFX3 to Facilitate Tumorigenesis and Progression of Glioma.	hsa_circ_0001836	circRFX3 	hsa_circ_RFX3	RFX3	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circRFX3/hsa_circ_0001836 is up-regulated in glioma cells and acts as an oncogenic circRNA. It promotes glioma cell proliferation, stemness, and xenograft tumor growth by recruiting HNRNPK to stabilize RFX3 mRNA and up-regulate its host gene RFX3, which further activates PROX1 transcription."	0.8537
35417749	"Clinical immunology (Orlando, Fla.)"	2022	Circ_0000854 regulates the progression of hepatocellular carcinoma through miR-1294 /IRGQ axis.	hsa_circ_0000854	circ_0000854 	hsa_circ_ZCCHC2	ZCCHC2	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"This study identified hsa_circ_0000854/circZCCHC2 as an up-regulated oncogenic circRNA in hepatocellular carcinoma. Circ_0000854 mainly localizes in the cytoplasm and promotes proliferation, cell cycle progression, migration, invasion, EMT-related protein changes, tumor growth and metastasis by sponging miR-1294 to increase IRGQ expression. High circ_0000854 expression was associated with poorer survival in HCC patients."	0.7981
35426037	"Reproductive sciences (Thousand Oaks, Calif.)"	2023	Melatonin Increases Proliferation and Decreases Apoptosis of GC-1 spg Cells by Upregulating the Expression of circTec.		chr5:73170660|73180483 	mmu_circ_Tec	Tec	male infertility 	MONDO:0005372	male infertility	up-regulated	RT-qPCR; RNA-seq	"In mouse GC-1 spg spermatogonial cells, melatonin upregulates circTec expression. circTec supports melatonin-induced proliferation, suppresses apoptosis, and promotes activation of the mTOR signaling pathway, suggesting potential relevance to spermatogenesis and male infertility treatment development."	0.642
35428519	"Auris, nasus, larynx"	2022	Hsa_circ_0081534 facilitates malignant phenotypes by sequestering miR-874-3p and upregulating FMNL3 in nasopharyngeal carcinoma.	hsa_circ_0081534	circ_0081534	hsa_circ_EPHB4	EPHB4	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"hsa_circ_0081534/circ_0081534 is upregulated in nasopharyngeal carcinoma tissues and cell lines and is associated with larger tumor size, advanced tumor stage, and lymph node metastasis. Functionally, it promotes NPC proliferation, migration, invasion, EMT, and tumor growth while suppressing apoptosis. Mechanistically, cytoplasmic circ_0081534 sponges miR-874-3p to increase FMNL3 expression, forming a circ_0081534/miR-874-3p/FMNL3 regulatory axis."	0.8175
35429518	The Journal of investigative dermatology	2022	Circular RNA Signatures of Human Healing and Nonhealing Wounds.		hsa-CHST15_0003	hsa_circ_CHST15	CHST15	venous ulcers 	MONDO:0043839	ulcer disease	up-regulated	RT-qPCR; RNA-seq	"hsa-CHST15_0003 is a human circRNA upregulated in venous ulcers. In keratinocytes, it inhibits migration and promotes proliferation/cell-cycle-related programs, potentially through a ceRNA mechanism involving miR-125b-5p/let-7a and SH2B3 as well as additional VU-related genes."	0.7008
35429518	The Journal of investigative dermatology	2022	Circular RNA Signatures of Human Healing and Nonhealing Wounds.		hsa-TNFRSF21_0001 	hsa_circ_TNFRSF21	TNFRSF21	venous ulcers 	MONDO:0043839	ulcer disease	up-regulated	RT-qPCR; RNA-seq	"hsa-TNFRSF21_0001 is a human circRNA upregulated in venous ulcers. It is mainly cytoplasmic in keratinocytes and promotes proliferation/cell cycle while suppressing migration and differentiation/EMT-related programs, thereby potentially contributing to the abnormal wound-edge keratinocyte phenotype in VU."	0.7008
35434854	Journal of gastroenterology and hepatology	2022	Circular RNA circ_0065378 upregulates tumor suppressor candidate 1 by competitively binding with miR-4701-5p to alleviate colorectal cancer progression.	hsa_circ_0065378	circ_PLXNB1 	hsa_circ_PLXNB1	PLXNB1	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"circ_PLXNB1/hsa_circ_0065378 is downregulated in colorectal cancer tissues and cell lines. Its overexpression suppresses CRC proliferation, invasion, migration, EMT and xenograft tumor growth by sponging miR-4701-5p, increasing TUSC1, and inactivating the TGF-beta/Smad pathway. Clinically, circ_PLXNB1 expression is associated with distant metastasis and lymph node metastasis."	0.8351
35436516	Neuroscience	2022	"CircXRCC5, as a Potential Novel Biomarker, Promotes Glioma Progression via the miR-490-3p/XRCC5/CLC3 Competing Endogenous RNA Network."		circXRCC5 	hsa_circ_XRCC5	XRCC5	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circXRCC5 is up-regulated in human glioma tissues and U87/U251 glioma cells, and its high expression is associated with poor patient survival. Functionally, circXRCC5 promotes glioma cell proliferation, migration and invasion while suppressing apoptosis. Mechanistically, circXRCC5 acts as a ceRNA sponge for miR-490-3p to regulate XRCC5 and CLC3 through the miR-490-3p/XRCC5/CLC3 axis."	0.8166
35436629	Biochemical and biophysical research communications	2022	CircRNA608-microRNA222-PINK1 axis regulates the mitophagy of hepatic stellate cells in NASH related fibrosis.		CircRNA608 			nonalcoholic steatohepatitis 	MONDO:0007027	metabolic dysfunction-associated steatohepatitis	down-regulated	RT-qPCR; RNA-seq	"Circ608 is down-regulated in lipotoxic hepatic stellate cells and in liver tissues from NASH-related liver fibrosis mice. The study proposes that circ608 inhibits miR222, which otherwise suppresses PINK1, thereby promoting PINK1-mediated mitophagy in hepatic stellate cells."	0.5416
35438362	Journal of bioenergetics and biomembranes	2022	CircCDC6 restrains tumor growth and glycolysis energy metabolism in colorectal cancer via regulating miR-3187-3p and downstream PRKAA2.	hsa_circ_0043526	circCDC6 	hsa_circ_CDC6	CDC6	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	"CircCDC6 is down-regulated in colorectal cancer tissues and cell lines, and higher circCDC6 expression is associated with better overall survival. Functionally, circCDC6 suppresses CRC cell proliferation, survival, glycolysis and xenograft tumor growth while promoting apoptosis. Mechanistically, it acts as a sponge for miR-3187-3p to upregulate PRKAA2 in the circCDC6/miR-3187-3p/PRKAA2 axis."	0.8146
35440759	Laboratory investigation; a journal of technical methods and pathology	2022	circHECTD1 attenuates apoptosis of alveolar epithelial cells in acute lung injury.		circHECTD1 	hsa_circ_HECTD1	HECTD1	acute lung injury 	MONDO:0015796	acute lung injury	down-regulated	RT-qPCR	"circHECTD1 is down-regulated in LPS-induced human and mouse alveolar epithelial cells and in LPS-induced ALI mouse lung tissues. Its overexpression suppresses alveolar epithelial cell apoptosis and alleviates mouse ALI by sponging miR-320a and miR-136, thereby up-regulating PIK3CA and Sirt1-related anti-apoptotic pathways."	0.6585
35440759	Laboratory investigation; a journal of technical methods and pathology	2022	circHECTD1 attenuates apoptosis of alveolar epithelial cells in acute lung injury.		circHECTD1 	mmu_circ_HECTD1	HECTD1	acute lung injury 	MONDO:0015796	acute lung injury	down-regulated	RT-qPCR	"circHECTD1 is down-regulated in LPS-induced human and mouse alveolar epithelial cells and in LPS-induced ALI mouse lung tissues. Its overexpression suppresses alveolar epithelial cell apoptosis and alleviates mouse ALI by sponging miR-320a and miR-136, thereby up-regulating PIK3CA and Sirt1-related anti-apoptotic pathways."	0.6585
35447224	Neuroscience letters	2022	Circular RNA circTLK1 regulates dopaminergic neuron injury during Parkinson's disease by targeting miR-26a-5p/DAPK1.		circTLK1	hsa_circ_TLK1	TLK1	Parkinson's disease 	MONDO:0005180	Parkinson disease	up-regulated	RT-qPCR	"circTLK1 is up-regulated in PD-related in vivo and in vitro dopaminergic neuron injury models. Its knockdown alleviates neuronal injury by improving viability and reducing apoptosis and cytotoxicity, mechanistically through the circTLK1/miR-26a-5p/DAPK1 regulatory axis. The study suggests circTLK1 as a potential therapeutic target for PD."	0.6542
35447224	Neuroscience letters	2022	Circular RNA circTLK1 regulates dopaminergic neuron injury during Parkinson's disease by targeting miR-26a-5p/DAPK1.		circTLK1	mmu_circ_TLK1	TLK1	Parkinson's disease 	MONDO:0005180	Parkinson disease	up-regulated	RT-qPCR	"circTLK1 is up-regulated in PD-related in vivo and in vitro dopaminergic neuron injury models. Its knockdown alleviates neuronal injury by improving viability and reducing apoptosis and cytotoxicity, mechanistically through the circTLK1/miR-26a-5p/DAPK1 regulatory axis. The study suggests circTLK1 as a potential therapeutic target for PD."	0.6542
35447227	Immunology letters	2022	Circ_100395 impedes malignancy and glycolysis in papillary thyroid cancer: Involvement of PI3K/AKT/mTOR signaling pathway.		circ_100395 			papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR	"Circ_100395 is down-regulated in PTC tissues and cell lines, and low expression correlates with advanced TNM stage, lymph node metastasis, and poor overall survival. Functionally, circ_100395 overexpression suppresses malignant phenotypes and glycolysis while promoting apoptosis. Mechanistically, its tumor-suppressive effects are mediated through inhibition of the PI3K/AKT/mTOR signaling pathway."	0.6589
35449370	Cellular and molecular life sciences : CMLS	2022	CircACTR2 in macrophages promotes renal fibrosis by activating macrophage inflammation and epithelial-mesenchymal transition of renal tubular epithelial cells.	hsa_circ_0008529	circular RNA ACTR2 	hsa_circ_ACTR2	ACTR2	renal fibrosis 	MONDO:0000494	renal fibrosis	up-regulated	RT-qPCR	"circACTR2 is up-regulated in UUO-induced renal fibrosis and promotes macrophage NLRP3 inflammasome activation, pyroptosis, and inflammation. Mechanistically, circACTR2 sponges miR-561 to increase NLRP3 expression, leading to IL-1beta secretion and paracrine induction of fascin-1-mediated EMT and fibrosis in renal tubular epithelial cells. Silencing circACTR2 alleviates renal fibrosis in vivo, suggesting therapeutic potential."	0.8278
35460386	Biochemical genetics	2022	Circ_0030998 Restrains Cisplatin Resistance Through Mediating miR-1323/PDCD4 Axis in Non-small Cell Lung Cancer.	hsa_circ_0030998	Circular RNA_0030998 	hsa_circ_LAMP1	LAMP1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"Circ_0030998 is a LAMP1-derived circRNA down-regulated in NSCLC, especially in DDP-resistant NSCLC tissues and cell lines. It suppresses cisplatin resistance and malignant phenotypes by sponging miR-1323 and up-regulating PDCD4, thereby inhibiting proliferation, migration, invasion and glycolysis while promoting apoptosis. Its reduced expression correlates with higher TNM stage and chemoresistance, suggesting potential therapeutic relevance."	0.8443
35460538	Head & neck	2022	Identification of the regulatory role of the circ_0004788/miR-515-5p/FGF2 network in nasopharyngeal carcinoma development.	hsa_circ_0004788	circ_0004788	hsa_circ_ROBO1	ROBO1	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"circ_0004788 is up-regulated in NPC tissues and cell lines and is associated with more advanced TNM stage. Functionally, circ_0004788 promotes NPC cell proliferation, migration, invasion, angiogenesis, sphere formation and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ_0004788 sponges miR-515-5p to increase FGF2 expression, forming a circ_0004788/miR-515-5p/FGF2 regulatory axis."	0.844
35460876	Transplant immunology	2022	Circ_0088036 mediated progression and inflammation in fibroblast-like synoviocytes of rheumatoid arthritis by miR-1263/REL-activated NF-kappaB pathway.	hsa_circ_0088036	circ_0088036	hsa_circ_SUSD1	SUSD1	Rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"circ_0088036 is up-regulated in sera and HFLS-RA cells from RA patients. It promotes HFLS-RA proliferation, cell cycle progression and inflammatory cytokine production while suppressing apoptosis, mainly through sponging miR-1263 to increase REL and activate NF-kappaB signaling. The study also suggests that its abnormal up-regulation may have diagnostic relevance in RA."	0.7982
35467292	Journal of cardiovascular translational research	2022	CircHIPK3 Regulates Vascular Smooth Muscle Cell Calcification Via the miR-106a-5p/MFN2 Axis.		CircHIPK3 	hsa_circ_HIPK3	HIPK3	atherosclerosis 	MONDO:0005311	atherosclerosis	down-regulated	RT-qPCR	"circHIPK3 is downregulated in atherosclerotic tissues, blood samples, and calcification-associated VSMC differentiation models. Functionally, circHIPK3 overexpression suppresses VSMC mineralization, calcium deposition, osteogenic differentiation, and chondrogenic differentiation. Mechanistically, circHIPK3 sponges miR-106a-5p to relieve repression of MFN2, forming a circHIPK3/miR-106a-5p/MFN2 regulatory axis that inhibits vascular calcification."	0.6675
35470728	Autoimmunity	2022	Circular RNA circ_0002594 regulates PDGF-BB-induced proliferation and migration of human airway smooth muscle cells via sponging miR-139-5p/TRIM8 in asthma.	hsa_circ_0002594	circ_0002594			asthma 	MONDO:0004979	asthma	up-regulated	RT-qPCR	"circ_0002594 is up-regulated in serum from asthma patients and in PDGF-BB-treated HASMC. It promotes PDGF-BB-induced HASMC proliferation, migration, invasion, EMT, and inflammatory cytokine release, at least partly by sponging miR-139-5p to regulate TRIM8 expression."	0.7799
35471687	Science China. Life sciences	2022	Circular RNA circCCNB1 inhibits the migration and invasion of nasopharyngeal carcinoma through binding and stabilizing TJP1 mRNA.		circCCNB1	hsa_circ_CCNB1	CCNB1	Nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	down-regulated	RT-qPCR	"circCCNB1 is downregulated in NPC tissues and cell lines and suppresses NPC cell migration and invasion. Mechanistically, it binds TJP1 mRNA and NF90, enhances NF90-TJP1 mRNA interaction, stabilizes TJP1 mRNA, and increases TJP1 expression, thereby strengthening tight junction-related suppression of metastasis-related phenotypes."	0.8478
35474406	Functional & integrative genomics	2022	"Knockdown of circMYOF inhibits cell growth, metastasis, and glycolysis through miR-145-5p/OTX1 regulatory axis in laryngeal squamous cell carcinoma."	hsa_circ_0019201	circMYOF 	hsa_circ_MYOF	MYOF	laryngeal squamous cell carcinoma 	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR	"circMYOF is upregulated in LSCC tissues, cells, and patient serum exosomes. It promotes LSCC proliferation, migration, invasion, metastasis, glycolysis, and tumor growth while suppressing apoptosis, mainly through the circMYOF/miR-145-5p/OTX1 regulatory axis. High circMYOF expression is associated with advanced tumor stage and poorer overall survival, and serum exosomal circMYOF is proposed as a diagnostic biomarker."	0.8769
35481453	Autoimmunity	2022	CircTRHDE knockdown protects WI-38 cells against LPS-induced inflammatory injury.	hsa_circ_0099188	circTRHDE	hsa_circ_TRHDE	TRHDE	infantile pneumonia	MONDO:0005249	pneumonia	up-regulated	RT-qPCR	"circTRHDE is up-regulated in serum from infantile pneumonia patients and in LPS-induced WI-38 cells. Functionally, circTRHDE promotes LPS-induced inflammatory injury, apoptosis and oxidative stress, while its knockdown is protective. Mechanistically, circTRHDE sponges miR-381-3p to positively regulate TRAF3 expression, suggesting a circTRHDE/miR-381-3p/TRAF3 axis and a potential therapeutic target for infantile pneumonia."	0.8111
35482822	"Cell cycle (Georgetown, Tex.)"	2023	CircRNA OXCT1 promotes the malignant progression and glutamine metabolism of non-small cell lung cancer by absorbing miR-516b-5p and upregulating SLC1A5.	hsa_circ_0004873	 circ-OXCT1	hsa_circ_OXCT1	OXCT1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ-OXCT1 is upregulated in NSCLC tissues and cell lines. It promotes malignant phenotypes and glutamine metabolism while suppressing apoptosis, acting through a circ-OXCT1/miR-516b-5p/SLC1A5 regulatory axis. Knockdown of circ-OXCT1 also inhibits xenograft tumor growth, suggesting therapeutic relevance."	0.8006
35500803	Annals of hepatology	2022	Circ_0005397 enhances hepatocellular carcinoma progression through miR-1283/HEG1.	hsa_circ_0005397	circ_0005397 	hsa_circ_RHOT1	RHOT1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0005397 is up-regulated in HCC tissues and cell lines and is associated with advanced stage and lymph node metastasis. It promotes HCC proliferation, migration, invasion, angiogenesis and xenograft tumor growth while suppressing apoptosis, mainly by sponging miR-1283 to up-regulate HEG1."	0.8175
35500847	Transplant immunology	2022	CircHIPK3 alleviates inflammatory response and neuronal apoptosis via regulating miR-382-5p/DUSP1 axis in spinal cord injury.	hsa_circ_0000284	circHIPK3 	hsa_circ_HIPK3	HIPK3	Spinal cord injury 	MONDO:0043797	spinal cord injury	down-regulated	RT-qPCR	"CircHIPK3 was down-regulated in OGD-induced AGE1.HN spinal cord injury cell models. Its overexpression alleviated inflammatory response and neuronal apoptosis and promoted cell proliferation by sponging miR-382-5p and regulating DUSP1 expression, suggesting circHIPK3 as a potential therapeutic target for SCI."	0.7204
35501594	"Reproductive sciences (Thousand Oaks, Calif.)"	2022	CircRNA VPRBP inhibits tumorigenicity of cervical cancer via miR-93-5p/FRMD6 axis.	hsa_circ_0065898	CircRNA VPRBP 	hsa_circ_VPRBP	VPRBP	cervical cancer	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR; Microarray	"Circ_VPRBP is down-regulated in cervical cancer tissues and cells. Its overexpression suppresses malignant phenotypes, including proliferation, migration, invasion, and in vivo tumor growth, while promoting apoptosis. Mechanistically, circ_VPRBP sponges miR-93-5p to increase FRMD6 expression, forming a circ_VPRBP/miR-93-5p/FRMD6 tumor-suppressive axis."	0.8325
35504053	Reproductive biology	2022	CircATRNL1 increases acid-sensing ion channel 1 to advance epithelial-mesenchymal transition in endometriosis by binding to microRNA-103a-3p.		Circular RNA ATRNL1 	hsa_circ_ATRNL1	ATRNL1	endometriosis	MONDO:0005133	endometriosis	up-regulated	RT-qPCR	"circATRNL1 is upregulated in endometriosis-related endometrial cancer cell lines and promotes Ishikawa cell proliferation, migration, invasion, and EMT. Mechanistically, circATRNL1 binds miR-103a-3p and increases ASIC1 expression, forming a circATRNL1/miR-103a-3p/ASIC1 axis that may serve as a therapeutic target for endometriosis."	0.5627
35521974	Journal of biochemical and molecular toxicology	2022	The transcription factor ZEB1 mediates the progression of epithelial ovarian cancer by promoting the transcription of CircANKRD17.	hsa_circ_0007883	CircANKRD17 	hsa_circ_ANKRD17	ANKRD17	epithelial ovarian cancer 	MONDO:0005140	ovarian carcinoma	up-regulated	RT-qPCR; RNA-seq	"CircANKRD17 is upregulated in epithelial ovarian cancer tissues and cell lines. ZEB1 transcriptionally promotes CircANKRD17 expression by binding the ANKRD17 promoter, and CircANKRD17 mediates ZEB1-driven EOC progression by promoting proliferation, invasion, migration, and EMT while inhibiting apoptosis."	0.7283
35522362	Applied biochemistry and biotechnology	2022	"Hsa_circ_0023984 Regulates Cell Proliferation, Migration, and Invasion in Esophageal Squamous Cancer via Regulating miR-1294/PI3K/Akt/c-Myc Pathway."	hsa_circ_0023984	circ_0023984	hsa_circ_NOX4	NOX4	esophageal squamous cancer 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0023984 is up-regulated in ESCC tissues and cell lines and is associated with larger tumor diameter and lymph node metastasis. Functionally, it promotes ESCC cell proliferation, migration, invasion, metastasis, and cell cycle progression. Mechanistically, circ_0023984 sponges miR-1294 and activates the PI3K/Akt/c-Myc pathway, increasing p-Akt and c-Myc expression."	0.7416
35543435	Autoimmunity	2022	"A novel circRNA, circRACGAP1, hampers the progression of systemic lupus erythematosus via miR-22-3p-mediated AKT signalling."	hsa_circ_0009035	circRACGAP1	hsa_circ_RACGAP1	RACGAP1	systemic lupus erythematosus 	MONDO:0007915	systemic lupus erythematosus	down-regulated	RT-qPCR	"circRACGAP1 (hsa_circ_0009035), derived from RACGAP1, is down-regulated in PBMCs from SLE patients and inversely associated with disease activity markers. Functionally, circRACGAP1 alleviates UVB-induced Jurkat cell apoptosis. Mechanistically, it sponges miR-22-3p to upregulate PTEN and suppress AKT signalling, suggesting potential diagnostic and therapeutic value in SLE."	0.814
35543802	Journal of molecular neuroscience : MN	2022	Whole Transcriptome Sequencing Identified CircRNA Profiles and the Related Networks in Schizophrenia.	hsa_circ_0003999				Schizophrenia 	MONDO:0005090	schizophrenia	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0003999 was down-regulated in schizophrenia and its differential expression was validated by RT-qPCR. The study suggests it may participate in SCZ-related circRNA regulatory networks and may have diagnostic relevance, although no direct functional assay was performed."	0.4032
35543802	Journal of molecular neuroscience : MN	2022	Whole Transcriptome Sequencing Identified CircRNA Profiles and the Related Networks in Schizophrenia.	hsa_circ_0030042				Schizophrenia 	MONDO:0005090	schizophrenia	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0030042 was down-regulated in schizophrenia and its differential expression was validated by RT-qPCR. The study suggests it may be part of SCZ-associated circRNA regulatory networks and may have diagnostic relevance, but direct mechanistic experiments were not performed."	0.4032
35543802	Journal of molecular neuroscience : MN	2022	Whole Transcriptome Sequencing Identified CircRNA Profiles and the Related Networks in Schizophrenia.	hsa_circ_0000008				Schizophrenia 	MONDO:0005090	schizophrenia	up-regulated	RNA-seq	"hsa_circ_0000008 was identified as an up-regulated circRNA in schizophrenia by whole transcriptome sequencing. The authors predicted that it may participate in SCZ pathophysiology through the hsa_circ_0000008/hsa-miR-1976/ZBTB16 ceRNA axis, but this association was not validated by RT-qPCR or functional experiments."	0.1768
35545863	"Cell cycle (Georgetown, Tex.)"	2022	"Circular RNA circ_0006089 regulates the IGF1R expression by targeting miR-143-3p to promote gastric cancer proliferation, migration and invasion."	hsa_circ_0006089	circ_0006089			gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circ_0006089 is up-regulated in gastric cancer tissues and cell lines, and high expression is associated with poorer overall survival and more aggressive clinicopathological features. Functionally, circ_0006089 promotes GC cell proliferation, migration and invasion. Mechanistically, it acts as a ceRNA for miR-143-3p, thereby increasing IGF1R expression and activating the PI3K/Akt/mTOR pathway."	0.7855
35549803	Immunopharmacology and immunotoxicology	2022	Circular RNA from phosphodiesterase 4D can attenuate chondrocyte apoptosis and matrix degradation under OA milieu induced by IL-1beta via circPDE4D/miR-4306/SOX9 Cascade.	hsa_circ_0072568	circPDE4D	hsa_circ_PDE4D	PDE4D	osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR	"CircPDE4D is a human PDE4D-derived circRNA downregulated in OA cartilage and IL-1beta-stressed human normal chondrocytes. Its restoration protects chondrocytes by promoting viability, proliferation, Bcl-2 and COL2A1 expression while inhibiting apoptosis, inflammatory mediators, and ECM-degrading factors. Mechanistically, circPDE4D acts through a circPDE4D/miR-4306/SOX9 ceRNA cascade and may represent a therapeutic target for OA."	0.8246
35549813	"Cell cycle (Georgetown, Tex.)"	2022	Hsa_circ_0103232 promotes melanoma cells proliferation and invasion via targeting miR-661/RAB3D.	hsa_circ_0103232	hsa_-circ_0103232 			melanoma	MONDO:0005105	melanoma	up-regulated	RT-qPCR; ISH	"Hsa_circ_0103232 is up-regulated in melanoma tissues and cell lines, and high expression predicts poor postoperative survival. Functionally, it promotes melanoma cell proliferation, migration, invasion, EMT, and xenograft tumor growth. Mechanistically, it acts as a cytoplasmic miR-661 sponge to increase RAB3D expression, suggesting therapeutic potential as a melanoma target."	0.807
35553305	Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing	2022	Circ-TLR4 promotes cardiac hypertrophy through recruiting FUS to stabilize TLR4 mRNA.		Circ-TLR4 	hsa_circ_TLR4	TLR4	cardiac hypertrophy 	MONDO:0001302	hypertensive heart disease	up-regulated	RT-qPCR	"Circ-TLR4 is up-regulated in an Ang II-induced human cardiomyocyte model of cardiac hypertrophy. It promotes hypertrophic responses by recruiting the RBP FUS to stabilize TLR4 mRNA and increase TLR4 expression; circ-TLR4 knockdown attenuates hypertrophy, while TLR4 overexpression partially rescues this effect."	0.7621
35567596	Cell biology and toxicology	2023	CircZNF609 promotes bladder cancer progression and inhibits cisplatin sensitivity via miR-1200/CDC25B pathway.	hsa_circ_0000615	Circ-ZNF609 	hsa_circ_ZNF609	ZNF609	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"CircZNF609 is up-regulated in bladder cancer tissues and cell lines and high expression is associated with worse overall survival. It promotes BCa proliferation, migration, cell cycle progression, tumor growth, and cisplatin resistance by sponging miR-1200 to increase CDC25B expression."	0.8814
35569812	Annals of hepatology	2022	Circ_0000291 contributes to hepatocellular carcinoma tumorigenesis by binding to miR-1322 to up-regulate UBE2T.	hsa_circ_0000291	circ_0000291	hsa_circ_CD44	CD44	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"Circ_0000291 is up-regulated in HCC tissues and cell lines and high expression predicts poor survival. Functionally, circ_0000291 promotes proliferation, migration, invasion, stemness and in vivo tumor growth while suppressing apoptosis. Mechanistically, it acts as a sponge for miR-1322 to up-regulate UBE2T, forming a circ_0000291/miR-1322/UBE2T axis that supports HCC progression."	0.8281
35579772	Biochemical genetics	2022	CircATIC Contributes to Multiple Myeloma Progression via miR-324-5p-Dependent Regulation of HGF.	hsa_circ_0058058	circATIC 	hsa_circ_ATIC	ATIC	multiple myeloma 	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR	"CircATIC is up-regulated in BM-derived plasma cells from MM patients and in MM cell lines. It promotes MM progression by enhancing proliferation, migration, invasion, cell-cycle progression, and glycolysis while suppressing apoptosis, mainly through sponging miR-324-5p to elevate HGF expression."	0.779
35579835	Environmental science and pollution research international	2022	Circ_0006404 enhances hepatocellular carcinoma progression by regulating miR-624.	hsa_circ_0006404	circ_0006404			hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0006404 is up-regulated in HCC specimens and HCC cell lines. Functionally, circ_0006404 promotes HCC cell growth, cell cycle progression, and migration, at least partly by sponging and suppressing miR-624. The study suggests circ_0006404 may serve as a potential biomarker for HCC."	0.6479
35581162	Chemistry & biodiversity	2022	Circ_0000284 Promoted Acute Pancreatitis Progression through the Regulation of miR-10a-5p/Wnt/beta-Catenin Pathway.	hsa_circ_0000284	circ_0000284 	hsa_circ_HIPK3	HIPK3	acute pancreatitis 	MONDO:0006515	acute pancreatitis	up-regulated	RT-qPCR	"This study found that circ_0000284/circHIPK3 is up-regulated in serum from acute pancreatitis patients and in caerulein-induced AR42J cells. Functional experiments indicate that circ_0000284 promotes AP-like cell injury, apoptosis, and inflammatory responses by sponging miR-10a-5p and modulating the Wnt/beta-catenin pathway. The authors propose circ_0000284 as a potential therapeutic target for acute pancreatitis."	0.7936
35590046	Digestive diseases and sciences	2023	"Knockdown of Circ_0003506 Impedes Radioresistance, Cell Growth, Migration and Invasion in Gastric Cancer."	hsa_circ_0003506	circ_0003506			gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"This study found that hsa_circ_0003506/circ_0003506 is upregulated in gastric cancer, especially in radioresistant GC tissues and cells. Circ_0003506 promotes GC radioresistance and malignant phenotypes by sponging miR-1256 and increasing BMPR2 expression; its knockdown suppresses proliferation, migration and invasion, promotes apoptosis, and enhances radiosensitivity in vitro and in vivo. The authors propose circ_0003506 as a potential diagnostic marker for radioresistance emergence and therapeutic target for restoring radiosensitivity in GC."	0.6835
35597500	Molecular and cellular probes	2022	Circ_0039960 regulates growth and Warburg effect of breast cancer cells via modulating miR-1178/PRMT7 axis.	hsa_circ_0039960	circ_0039960	hsa_circ_PRMT7	PRMT7	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0039960 is up-regulated in breast cancer tissues and cell lines, and high expression is associated with poor survival. Functionally, circ_0039960 promotes BC cell growth, cell cycle progression and Warburg effect while suppressing apoptosis. Mechanistically, circ_0039960 sponges miR-1178 to positively regulate PRMT7 expression, forming a circ_0039960/miR-1178/PRMT7 axis."	0.87
35598218	Molecular and cellular biochemistry	2022	The circ_FAM53B-miR-183-5p-CCDC6 axis modulates the malignant behaviors of papillary thyroid carcinoma cells.	hsa_circ_0000266	circ_FAM53B 	hsa_circ_FAM53B	FAM53B	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR	"circ_FAM53B is down-regulated in papillary thyroid carcinoma tissues and cells and is mainly localized in the cytoplasm. It acts as a tumor suppressor by sponging miR-183-5p, thereby increasing CCDC6 expression, which inhibits proliferation, migration, invasion, tube formation and tumor growth while promoting apoptosis. Clinically, circ_FAM53B expression was associated with recurrence and lymph node metastasis and may serve as a potential diagnostic biomarker or therapeutic target in PTC."	0.8175
35616807	Molecular and cellular biochemistry	2022	"Hsa_circ_0006732 regulates colorectal cancer cell proliferation, invasion and EMT by miR-127-5p/RAB3D axis."	hsa_circ_0006732	circZDHHC20	hsa_circ_ZDHHC20	ZDHHC20	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"hsa_circ_0006732 is up-regulated in colorectal cancer tissues and cell lines and is associated with tumor size, TNM stage and poor prognosis. Functionally, it promotes CRC cell proliferation, migration, invasion and EMT. Mechanistically, it acts as a ceRNA that sponges miR-127-5p to regulate RAB3D."	0.6521
35624316	Functional & integrative genomics	2022	CircPVT1 facilitates the progression of oral squamous cell carcinoma by regulating miR-143-3p/SLC7A11 axis through MAPK signaling pathway.		circPVT1	hsa_circ_PVT1	PVT1	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"CircPVT1 is upregulated in OSCC tissues and cells. It promotes OSCC proliferation, migration, invasion, metastasis and xenograft tumor growth while suppressing apoptosis, mainly by sponging miR-143-3p to increase SLC7A11 and activate the p38/ERK MAPK pathway."	0.7294
35636640	Molecular and cellular probes	2022	circNup188/miR-760-3p/Map3k8 axis regulates inflammation in cerebral ischemia.		circNup188	rno_circ_Nup188	Nup188	cerebral ischemia	MONDO:0002679	cerebral infarction	up-regulated	RT-qPCR	"circNup188 is up-regulated in an OGD/R PC12 cell model of cerebral ischemia. It promotes inflammatory injury by sponging miR-760-3p, increasing Map3k8 expression, and activating the NF-kappaB pathway; knockdown of circNup188 reduces inflammatory cytokine release and apoptosis while improving cell viability."	0.7216
35637250	Oncogene	2022	Glioblastoma-associated microglia-derived exosomal circKIF18A promotes angiogenesis by targeting FOXC2.	hsa_circ_0021535	circKIF18A	hsa_circ_KIF18A	KIF18A	glioblastoma multiforme 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; RNA-seq	"Human M2 microglia-derived exosomal circKIF18A is up-regulated in M2-MDEs and can be transferred into hBMECs. It promotes GBM angiogenesis by binding FOXC2, stabilizing FOXC2 protein and promoting its nuclear translocation, thereby enhancing ITGB3, CXCR4 and DLL4 transcription and activating PI3K/AKT signaling."	0.8599
35637250	Oncogene	2022	Glioblastoma-associated microglia-derived exosomal circKIF18A promotes angiogenesis by targeting FOXC2.	mmu_circ_0009168				glioblastoma multiforme 	MONDO:0018177	glioblastoma	unknown	RT-qPCR	"mmu_circ_0009168 is the mouse homolog of circKIF18A and was manipulated in BV-2-derived M2 microglial exosomes for in vivo testing. In a C57BL/6 syngeneic GBM model, mmu_circ_0009168 overexpression promoted tumor growth, angiogenesis markers and reduced survival, while knockdown showed opposite effects."	0.5736
35644224	The American journal of the medical sciences	2022	CircRNA circ-MYBL2 absorbs precursor miR-92b in the nucleus to suppress its role in enhancing gastric cancer cell proliferation.		Circ-MYBL2	hsa_circ_MYBL2	MYBL2	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; RNA-seq	"Circ-MYBL2 is down-regulated in gastric cancer tissues and cell lines. It acts as a tumor-suppressive circRNA by binding precursor miR-92b, suppressing miR-92b maturation, and inhibiting gastric cancer cell proliferation and xenograft tumor growth."	0.6824
35644449	The journal of obstetrics and gynaecology research	2022	Circ-0002814 participates in proliferation and migration through miR-210 and FUS/VEGF pathway of preeclampsia.	hsa_circ_0002814	Circ-0002814 	hsa_circ_HERC2	HERC2	preeclampsia 	MONDO:0005081	preeclampsia	down-regulated	RT-qPCR	"hsa_circ_0002814 is down-regulated in the placenta and circulating samples of patients with preeclampsia. Functionally, circ_0002814 promotes trophoblast proliferation, migration, and invasion. Mechanistically, it regulates Notch1/CPEB2 through miR-210 and directly interacts with FUS to modulate the FUS/VEGF axis, supporting its potential as a diagnostic marker and therapeutic target."	0.7283
35657460	Neurochemical research	2022	Exosomes Secreted from circZFHX3-modified Mesenchymal Stem Cells Repaired Spinal Cord Injury Through mir-16-5p/IGF-1 in Mice.	mmu_circ_0001723	circZFHX3 	mmu_circ_ZFHX3	ZFHX3	spinal cord injury 	MONDO:0043797	spinal cord injury	down-regulated	RT-qPCR	"This study found that circZFHX3 is decreased in SCI mice and LPS-treated BV-2 microglial cells, while BMSC-derived exosomes enriched with circZFHX3 alleviate SCI-related cellular injury. Mechanistically, exosomal circZFHX3 sponges miR-16-5p to upregulate IGF-1, promoting cell viability and inhibiting apoptosis, inflammation and oxidative stress, thereby improving functional recovery after SCI in mice."	0.7406
35661247	Journal of pineal research	2022	Melatonin may suppress lung adenocarcinoma progression via regulation of the circular noncoding RNA hsa_circ_0017109/miR-135b-3p/TOX3 axis.	hsa_circ_0017109	circ_0017109 	hsa_circ_NID1	NID1	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0017109 is up-regulated in LUAD/NSCLC and is associated with more aggressive clinicopathological features. Functionally, it promotes lung cancer cell proliferation, migration, invasion and metastasis while reducing apoptosis. Mechanistically, melatonin suppresses LUAD progression by inhibiting hsa_circ_0017109, which releases miR-135b-3p to downregulate TOX3 and inhibit Hippo signaling and EMT-related programs."	0.7901
35670955	Neurotoxicity research	2022	Circ-HUWE1 Knockdown Alleviates Amyloid-beta-Induced Neuronal Injury in SK-N-SH Cells via miR-433-3p Release-Mediated FGF7 Downregulation.	hsa_circ_0090682	circ_0090682 	hsa_circ_HUWE1	HUWE1	Alzheimer's disease 	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR	"circ-HUWE1 is up-regulated in serum from AD patients and in Abeta 1-40-treated SK-N-SH cells, with diagnostic potential for AD. Functionally, circ-HUWE1 promotes Abeta-induced neuronal injury, apoptosis, and inflammatory responses, while its knockdown is protective. Mechanistically, circ-HUWE1 sponges miR-433-3p to regulate FGF7 and the Wnt/beta-catenin signaling pathway."	0.7846
35676548	Biochemical genetics	2022	CircCERS6 Suppresses the Development of Epithelial Ovarian Cancer Through Mediating miR-630/RASSF8.	hsa_circ_0007024	circ-CERS6	hsa_circ_CERS6	CERS6	epithelial ovarian cancer 	MONDO:0005140	ovarian carcinoma	down-regulated	RT-qPCR	"CircCERS6/hsa_circ_0007024 is down-regulated in EOC tissues and cell lines. It functions as a tumor suppressor by sponging miR-630 and thereby up-regulating RASSF8, which inhibits EOC cell proliferation, migration, invasion, EMT, and xenograft tumor growth. The circCERS6/miR-630/RASSF8 axis is proposed as a potential therapeutic target for EOC."	0.8571
35678923	Clinical and experimental nephrology	2022	"Circ_0000064 knockdown attenuates high glucose-induced proliferation, inflammation and extracellular matrix deposition of mesangial cells through miR-424-5p-mediated WNT2B inhibition in cell models of diabetic nephropathy."	hsa_circ_0000064	circ_0000064	hsa_circ_B4GALT2	B4GALT2	diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"In this study, circ_0000064 was upregulated in HG-treated human renal mesangial cells and in kidney biopsy samples from DN patients. Functionally, circ_0000064 promoted HG-induced proliferation, inflammation, cell cycle progression and ECM accumulation, while its knockdown alleviated these DN-related phenotypes. Mechanistically, circ_0000064 acted as a miR-424-5p sponge to upregulate WNT2B, supporting the circ_0000064/miR-424-5p/WNT2B axis as a potential biomarker or therapeutic mechanism in DN."	0.7591
35680727	Cellular and molecular life sciences : CMLS	2022	EIF4A3-induced circFIP1L1 represses miR-1253 and promotes radiosensitivity of nasopharyngeal carcinoma.	hsa_circ_0069740	circFIP1L1 	hsa_circ_FIP1L1	FIP1L1	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; RNA-seq	"circFIP1L1 (circ_0069740), derived from FIP1L1, is increased in NPC after radiation treatment. It suppresses NPC proliferation, promotes apoptosis, inhibits tumor growth, and enhances radiosensitivity through a miR-1253/EIF4A3-related mechanism. EIF4A3 also promotes circFIP1L1 biogenesis and is recruited by circFIP1L1 to stabilize PTEN mRNA, supporting circFIP1L1 as a potential therapeutic target in NPC radioresistance."	0.8817
35687299	Journal of molecular neuroscience : MN	2022	circ-Ncam2 (mmu_circ_0006413) Participates in LPS-Induced Microglia Activation and Neuronal Apoptosis via the TLR4/NF-kappaB Pathway.	mmu_circ_0006413		mmu_circ_Ncam2	Ncam2	Spinal cord injury 	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR	"circ-Ncam2/mmu_circ_0006413 is up-regulated in LPS-stimulated BV2 microglia and is implicated in secondary SCI-related inflammatory injury. It promotes microglial activation, inflammatory cytokine dysregulation, and HT22 neuronal apoptosis by sponging miR-544-3p, increasing TLR4 expression, and activating NF-kappaB signaling."	0.7822
35687903	Placenta	2022	CircFBXW4 regulates human trophoblast cell proliferation and invasion via targeting miR-324-3p/TJP1 axis in recurrent spontaneous abortion.	hsa_circ_0008362	circFBXW4	hsa_circ_FBXW4	FBXW4	recurrent spontaneous abortion 	MONDO:0005047	infertility disorder	up-regulated	RT-qPCR; RNA-seq	"circFBXW4 is significantly up-regulated in placental villi from RSA patients. It acts through a circFBXW4/miR-324-3p/TJP1 ceRNA axis and regulates trophoblast proliferation, invasion, and apoptosis, suggesting potential relevance to RSA pathogenesis and therapy."	0.8035
35687903	Placenta	2022	CircFBXW4 regulates human trophoblast cell proliferation and invasion via targeting miR-324-3p/TJP1 axis in recurrent spontaneous abortion.	hsa_circ_0007291				recurrent spontaneous abortion 	MONDO:0005047	infertility disorder	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0007291 was identified by RNA-sequencing and validated by qRT-PCR as significantly up-regulated in placental villus samples from RSA patients. No specific functional mechanism or interaction axis was investigated for this circRNA in the study.	0.4773
35687903	Placenta	2022	CircFBXW4 regulates human trophoblast cell proliferation and invasion via targeting miR-324-3p/TJP1 axis in recurrent spontaneous abortion.	hsa_circ_0007769				recurrent spontaneous abortion 	MONDO:0005047	infertility disorder	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0007769 was identified by RNA-sequencing and validated by qRT-PCR as significantly up-regulated in placental villus samples from RSA patients. No specific biological function, interacting miRNA, or regulatory mechanism was further studied for this circRNA."	0.4773
35689709	Biochemical genetics	2023	Circ_0005925 Promotes Granulosa Cell Growth by Targeting MiR-324-3p to Upregulate MAP2K6 in Polycystic Ovary Syndrome.	hsa_circ_0005925	circ_0005925	hsa_circ_PILRB	PILRB	polycystic ovary syndrome 	MONDO:0008487	polycystic ovary syndrome	up-regulated	RT-qPCR	"circ_0005925 is upregulated in granulosa cells from PCOS patients and in KGN/SVOG granulosa cell lines. It promotes granulosa cell growth by enhancing proliferation and suppressing apoptosis through a ceRNA mechanism in which circ_0005925 sponges miR-324-3p to upregulate MAP2K6, suggesting potential therapeutic relevance in PCOS."	0.7795
35697768	Hypertension research : official journal of the Japanese Society of Hypertension	2022	"Circ_FURIN promotes trophoblast cell proliferation, migration and invasion in preeclampsia by regulating miR-34a-5p and TFAP2A."	hsa_circ_0036877		hsa_circ_FURIN	FURIN	preeclampsia 	MONDO:0005081	preeclampsia	down-regulated	RT-qPCR	"circ_FURIN is downregulated in PE placental tissues and hypoxia-treated human trophoblast cells. Functionally, circ_FURIN overexpression promotes trophoblast proliferation, migration and invasion under hypoxic conditions. Mechanistically, circ_FURIN sponges miR-34a-5p to increase TFAP2A expression, forming a circ_FURIN/miR-34a-5p/TFAP2A axis that may provide a therapeutic target for PE."	0.7785
35699802	Applied biochemistry and biotechnology	2022	Circular RNA Hecw1 Regulates the Inflammatory Imbalance in Spinal Cord Injury via miR-3551-3p/LRRTM1 Axis.		circ Hecw1 	rno_circ_Hecw1	Hecw1	Spinal cord injury 	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR	"This study investigated rat circRNA Hecw1 in an LPS-induced PC12 cellular model of spinal cord injury inflammation. circHecw1 was up-regulated after LPS stimulation, mainly localized in the cytoplasm, and its knockdown promoted proliferation while reducing apoptosis and inflammatory cytokine production. Mechanistically, circHecw1 was proposed to act as a ceRNA that sequesters miR-3551-3p to regulate LRRTM1 signaling."	0.5979
35707935	Journal of biochemical and molecular toxicology	2022	Negative regulation of miR-1288-3p/KRT4 axis through a circular RNA in oral cancer.	hsa_circ_0096042	circ_0096042			oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR	"hsa_circ_0096042 is downregulated in OSCC tissues and cell lines and is mainly localized in the cytoplasm. Functionally, its overexpression suppresses oral cancer cell viability and proliferation, promotes apoptosis, and inhibits xenograft tumor growth. Mechanistically, hsa_circ_0096042 acts as a sponge for miR-1288-3p to regulate KRT4 in the hsa_circ_0096042/miR-1288-3p/KRT4 axis."	0.7968
35708677	"Cell cycle (Georgetown, Tex.)"	2022	circFCHO2 promotes gastric cancer progression by activating the JAK1/STAT3 pathway via sponging miR-194-5p.	hsa_circ_0072979	circFCHO2	hsa_circ_FCHO2	FCHO2	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circFCHO2 is up-regulated in gastric cancer tissues, cell lines and serum exosomes, and high expression is associated with poor clinical outcome and metastasis. Functionally, circFCHO2 promotes GC proliferation, invasion, angiogenesis, stem-like properties, tumor growth and metastasis. Mechanistically, it acts as a cytoplasmic miR-194-5p sponge to increase JAK1 and activate the JAK1/STAT3 pathway, and serum exosomal circFCHO2 may serve as a diagnostic marker."	0.8921
35710093	Cancer letters	2022	Down-regulation of circPTTG1IP induces hepatocellular carcinoma development via miR-16-5p/RNF125/JAK1 axis.	hsa_circ_0061984	circ_0061984 	hsa_circ_PTTG1IP	PTTG1IP	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"circPTTG1IP is a human chromosome 21-derived tumor suppressor circRNA that is downregulated in HCC and whose low expression predicts poor prognosis. It suppresses HCC malignancy by sponging miR-16-5p to increase RNF125, leading to ubiquitination and degradation of JAK1 and inhibition of JAK1-STAT3 signaling. Loss of circPTTG1IP promotes tumor progression and macrophage recruitment/M2 polarization, while the JAK1 inhibitor filgotinib counteracts these effects."	0.8984
35716110	"American journal of reproductive immunology (New York, N.Y. : 1989)"	2022	Circ_0060551 promotes the migration and invasion of cervical cancer by upregulating TPD52.	hsa_circ_0060551	circ_0060551			cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"circ_0060551 is up-regulated in cervical cancer cells and promotes cell migration and invasion. Mechanistically, it up-regulates TPD52 by sponging miR-520a-5p in a ceRNA axis and also recruits ELAVL1 to stabilize TPD52 mRNA."	0.7404
35723551	Autoimmunity	2022	CircCDK14 ameliorates interleukin-1beta-induced chondrocyte damage by the miR-1183/KLF5 pathway in osteoarthritis.	hsa_circ_0001722	circCDK14 	hsa_circ_CDK14	CDK14	osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR	"CircCDK14 is down-regulated in OA cartilage tissues, IL-1b-treated chondrocytes, and serum exosomes from OA patients. Its overexpression protects chondrocytes from IL-1b-induced injury by promoting proliferation, inhibiting apoptosis, and reducing ECM degradation through the miR-1183/KLF5 axis. Serum exosomal circCDK14 also has potential diagnostic value for OA."	0.8562
35723810	Biochemical genetics	2023	"Silencing CircEIF3I/miR-526b-5p Axis Epigenetically Targets HGF/c-Met Signal to Hinder the Malignant Growth, Metastasis and Angiogenesis of Hepatocellular Carcinoma."	hsa_circ_0011385	circEIF3I 	hsa_circ_EIF3I	EIF3I	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"CircEIF3I is up-regulated in HCC tissues and cells and functions as an oncogenic circRNA. It promotes malignant growth, EMT, migration, invasion, angiogenesis and xenograft tumor growth while suppressing apoptosis. Mechanistically, circEIF3I sponges miR-526b-5p to regulate HGF and the HGF/c-Met signaling pathway, suggesting therapeutic potential for targeting the circEIF3I/miR-526b-5p/HGF axis in HCC."	0.8512
35724730	Genomics	2022	Profiling and integrated analysis of differentially expressed circRNAs in cervical cancer.	hsa_circ_0089761				cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	hsa_circ_0089761 was identified by circRNA array and validated by RT-qPCR as significantly up-regulated in cervical cancer tissues compared with normal cervix tissues. No individual functional mechanism was tested for this circRNA in the study.	0.4773
35724730	Genomics	2022	Profiling and integrated analysis of differentially expressed circRNAs in cervical cancer.	hsa_circ_0003692				cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	hsa_circ_0003692 was identified by circRNA array and validated by RT-qPCR as significantly up-regulated in cervical cancer tissues. The study did not perform functional or mechanistic experiments for this circRNA.	0.4773
35724730	Genomics	2022	Profiling and integrated analysis of differentially expressed circRNAs in cervical cancer.	hsa_circ_0004226	hsa_-circ_0004226			cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	hsa_circ_0004226 was significantly up-regulated in cervical cancer tissues compared with normal cervix tissues and its expression change was validated by RT-qPCR. No circRNA-specific functional experiments or mechanism were reported for hsa_circ_0004226.	0.4773
35724730	Genomics	2022	Profiling and integrated analysis of differentially expressed circRNAs in cervical cancer.	hsa_circ_0000550	hsa_-circ_0000550			cervical cancer 	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR; Microarray	hsa_circ_0000550 was identified and RT-qPCR-validated as significantly down-regulated in cervical cancer tissues compared with normal cervix tissues. The paper did not report functional assays or a specific molecular mechanism for this circRNA.	0.4773
35724730	Genomics	2022	Profiling and integrated analysis of differentially expressed circRNAs in cervical cancer.	hsa_circ_0041551				cervical cancer 	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR; Microarray	hsa_circ_0041551 was detected as a down-regulated circRNA in cervical cancer tissues and its decreased expression was confirmed by RT-qPCR. The study did not provide circRNA-specific functional validation or mechanistic analysis for hsa_circ_0041551.	0.4773
35724730	Genomics	2022	Profiling and integrated analysis of differentially expressed circRNAs in cervical cancer.	hsa_circ_0026377		hsa_circ_KRT81	KRT81	cervical cancer 	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0026377, generated from exons 2-9 of KRT81, was down-regulated in cervical cancer and validated by RT-qPCR. Functional gain-of-function assays showed that hsa_circ_0026377 suppresses HeLa and SiHa cell proliferation, migration and invasion. Bioinformatics analyses placed hsa_circ_0026377 in a predicted circRNA-miRNA-mRNA ceRNA network, suggesting it may regulate cervical cancer progression through miRNA-mediated target gene pathways."	0.7399
35726081	Neurotoxicity research	2022	Circular RNA hsa_circ_0004381 Promotes Neuronal Injury in Parkinson's Disease Cell Model by miR-185-5p/RAC1 Axis.	hsa_circ_0004381		hsa_circ_ARID1B	ARID1B	Parkinson's disease 	MONDO:0005180	Parkinson disease	up-regulated	RT-qPCR	"This study found that hsa_circ_0004381 is up-regulated in serum from Parkinson's disease patients and in MPP+-treated SK-N-SH cells. Functionally, hsa_circ_0004381 promotes neuronal injury by reducing cell viability and increasing apoptosis, inflammatory response, and oxidative stress. Mechanistically, it acts as a sponge for miR-185-5p to increase RAC1 expression in the PD cell model."	0.8107
35729462	Inflammation	2022	"Circ_0060077 Knockdown Alleviates High-Glucose-Induced Cell Apoptosis, Oxidative Stress, Inflammation and Fibrosis in HK-2 Cells via miR-145-5p/VASN Pathway."	hsa_circ_0060077	circ_0060077	hsa_circ_CEP250	CEP250	diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"Circ_0060077 is up-regulated in peripheral blood from DN patients and in high-glucose-treated HK-2 cells. Functionally, circ_0060077 promotes HG-induced HK-2 cell injury by suppressing proliferation and enhancing apoptosis, oxidative stress, inflammation and fibrosis. Mechanistically, it acts through a ceRNA-like miR-145-5p/VASN axis."	0.7595
35748299	Clinical and experimental pharmacology & physiology	2022	Circ_0017274 acts on miR-637/CDX2 axis to facilitate cisplatin resistance in gastric cancer.	hsa_circ_0017274	circ_0017274	hsa_circ_HNRNPU	HNRNPU	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_0017274 is up-regulated in cisplatin-resistant gastric cancer tissues and cells. It promotes CDDP resistance and malignant phenotypes by sponging miR-637 and regulating CDX2, while circ_0017274 knockdown enhances CDDP sensitivity, suppresses proliferation, migration and invasion, promotes apoptosis, and inhibits xenograft tumour growth."	0.8325
35748916	Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]	2023	CircDLG1 promotes malignant development of non-small cell lung cancer through regulation of the miR-630/CENPF axis.	hsa_circ_0068706	circDLG1	hsa_circ_DLG1	DLG1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"CircDLG1 is up-regulated in NSCLC tissues and cell lines, and high expression is associated with lymph node metastasis and poor overall survival. Functionally, circDLG1 promotes NSCLC cell proliferation, migration, invasion, and in vivo tumor growth while suppressing apoptosis. Mechanistically, it acts as a miR-630 sponge to increase CENPF expression through the circDLG1/miR-630/CENPF axis."	0.7975
35750765	"Cancer immunology, immunotherapy : CII"	2023	"Circ-HSP90A expedites cell growth, stemness, and immune evasion in non-small cell lung cancer by regulating STAT3 signaling and PD-1/PD-L1 checkpoint."	hsa_circ_0033393	circ-HSP90A	hsa_circ_HSP90A		non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"In this study, hsa_circ_0033393/circ-HSP90A is an HSP90A-derived circRNA up-regulated in NSCLC cells. It promotes proliferation, migration, invasion, stemness, and immune evasion by recruiting USP30 to stabilize HSP90A and activate STAT3 signaling, and by sponging miR-424-5p to increase PD-L1 expression and suppress CD8 + T-cell activity."	0.8093
35759163	Apoptosis : an international journal on programmed cell death	2022	Circ_0000523 regulates miR-1184/COL1A1/PI3K/Akt pathway to promote nasopharyngeal carcinoma progression.	hsa_circ_0000523	circ_0000523	hsa_circ_METTL3	METTL3	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"Circ_0000523 is a METTL3-derived circRNA that is up-regulated in NPC tissues and cell lines. It promotes NPC progression by targeting and repressing miR-1184, thereby increasing COL1A1 expression and activating the PI3K/Akt pathway, leading to enhanced proliferation, cell cycle progression, migration, invasion and metastasis."	0.7662
35763173	Biochemical genetics	2023	Propofol Suppresses Glioma Tumorigenesis by Regulating circ_0047688/miR-516b-5p/IFI30 Axis.	hsa_circ_0047688	circ_0047688			glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ_0047688 is upregulated in glioma tissues and cells and acts as a tumor-promoting circRNA. Its knockdown suppresses glioma cell proliferation, migration, invasion, EMT-related marker changes, and tumor growth while promoting apoptosis. Mechanistically, propofol exerts anti-tumor activity partly by downregulating circ_0047688, which otherwise sponges miR-516b-5p to increase IFI30 expression."	0.6544
35766911	The European journal of neuroscience	2022	Circ_TLK1 knockdown alleviates oxygen-glucose deprivation/reoxygenation-induced PC12 cell injury by regulating microRNA-136-5p/follistatin like-1 axis.	hsa_circ_0057030	circ_TLK1	hsa_circ_TLK1	TLK1	ischemic stroke 	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR	"This study shows that circ_TLK1 is upregulated in OGD/R-injured PC12 cells. Functionally, circ_TLK1 knockdown protects PC12 cells from OGD/R-induced injury by improving proliferation/survival and reducing cell death, apoptosis-associated protein changes, and LDH release. Mechanistically, circ_TLK1 sponges miR-136-5p to positively regulate FSTL1 expression, forming a circ_TLK1/miR-136-5p/FSTL1 axis relevant to ischemic stroke-related cellular injury."	0.6945
35766911	The European journal of neuroscience	2022	Circ_TLK1 knockdown alleviates oxygen-glucose deprivation/reoxygenation-induced PC12 cell injury by regulating microRNA-136-5p/follistatin like-1 axis.	mmu_circ_0010146	circ_TLK1	rno_circ_TLK1	TLK1	ischemic stroke 	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR	"This study shows that circ_TLK1 is upregulated in OGD/R-injured PC12 cells. Functionally, circ_TLK1 knockdown protects PC12 cells from OGD/R-induced injury by improving proliferation/survival and reducing cell death, apoptosis-associated protein changes, and LDH release. Mechanistically, circ_TLK1 sponges miR-136-5p to positively regulate FSTL1 expression, forming a circ_TLK1/miR-136-5p/FSTL1 axis relevant to ischemic stroke-related cellular injury."	0.6945
35775884	"Cell cycle (Georgetown, Tex.)"	2022	Circ_0061395 functions as an oncogenic gene in hepatocellular carcinoma by acting as a miR-1182 sponge.	hsa_circ_0061395	Circular RNA_0061395 	hsa_circ_BACH1	BACH1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0061395 is up-regulated in HCC tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation, migration, invasion, angiogenesis, tumor spheroid formation, EMT and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ_0061395 sponges miR-1182 to increase SPOCK1 expression, forming a circ_0061395/miR-1182/SPOCK1 regulatory axis."	0.8175
35776289	Journal of physiology and biochemistry	2022	circ-CCND1 regulates the CCND1/P53/P21 pathway through sponging miR-138-5p in valve interstitial cells to aggravate aortic valve calcification.		circular-CCND1 	hsa_circ_CCND1	CCND1	calcified aortic valve disease 	MONDO:0003803	aortic valve disorder	up-regulated	RT-qPCR; Microarray	"circ-CCND1 is up-regulated in calcified aortic valve leaflets and promotes calcification and osteogenic differentiation of valve interstitial cells. Mechanistically, it sponges miR-138-5p to regulate CCND1 and activate the CCND1/P53/P21 pathway, suggesting potential diagnostic and therapeutic relevance in CAVD."	0.6675
35776379	Neurotoxicity research	2022	Circular RNA VPS18 Promotes Glioblastoma Progression by Regulating miR-1229-3p/BCAT1 Axis.	hsa_circ_0034642	Circular RNA VPS18 	hsa_circ_VPS18	VPS18	glioblastoma	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR	"CircVPS18 is up-regulated in glioblastoma tissues and cells and its high expression is associated with poor overall survival. Functionally, circVPS18 promotes proliferation, cell-cycle progression, angiogenesis, migration, invasion, tumor growth and metastasis, while suppressing apoptosis. Mechanistically, cytoplasmic circVPS18 sponges miR-1229-3p to relieve repression of BCAT1, forming a circVPS18/miR-1229-3p/BCAT1 axis that drives glioblastoma progression."	0.8557
35793013	Metabolic brain disease	2022	Circular RNA circ_0079593 facilitates glioma development via modulating miR-324-5p/XBP1 axis.	hsa_circ_0079593	circ_0079593	hsa_circ_IGF2BP3	IGF2BP3	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ_0079593 is up-regulated in glioma tissues and cell lines and is mainly cytoplasmic. It promotes glioma proliferation, migration, invasion, angiogenesis, glycolysis and in vivo tumor growth while suppressing apoptosis. Mechanistically, circ_0079593 acts as a ceRNA for miR-324-5p to increase XBP1 expression, forming the circ_0079593/miR-324-5p/XBP1 axis and suggesting therapeutic potential in glioma."	0.8175
35794253	International journal of clinical oncology	2022	The tumor suppressor function of hsa_circ_0006282 in gastric cancer through PTEN/AKT pathway.	hsa_circ_0006282		hsa_circ_ELOC	ELOC	gastric cancer	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"hsa_circ_0006282 is down-regulated in gastric cancer tissues and cells and functions as a tumor suppressor. It suppresses gastric cancer cell proliferation, migration and resistance to apoptosis by sponging hsa-miR-136-5p, promoting PTEN expression, and modulating the PTEN/AKT pathway. The study also suggests potential diagnostic biomarker value for gastric cancer."	0.7992
35794450	Molecular biotechnology	2023	Circular RNA hsa_circ_0012673 Promotes Breast Cancer Progression via miR-576-3p/SOX4 Axis.	hsa_circ_0012673	hsa_ circ_0012673 	hsa_circ_DHCR24	DHCR24	breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"hsa_circ_0012673 is upregulated in breast cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes breast cancer cell proliferation, migration and invasion by sponging miR-576-3p and upregulating SOX4 through a ceRNA mechanism. The study suggests hsa_circ_0012673 may have potential value as a biomarker and therapeutic target for breast cancer."	0.6536
35796939	Human cell	2022	Exosomal hsa_circ_0017252 attenuates the development of gastric cancer via inhibiting macrophage M2 polarization.	hsa_circ_0017252				gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"hsa_circ_0017252 is downregulated in GC tissues, serum, and GC cells. It suppresses GC malignancy by sponging miR-17-5p, upregulating DUSP2, reducing p-STAT3 signaling, inhibiting macrophage M2-like polarization, and thereby decreasing GC cell migration, invasion, EMT-like changes, and tumor growth while promoting apoptosis."	0.7761
35804263	"Hormones (Athens, Greece)"	2022	CircRTN1 acts as a miR-431-5p sponge to promote thyroid cancer progression by upregulating TGFA.	hsa_circ_0102272	circRTN1 	hsa_circ_RTN1	RTN1	thyroid cancer 	MONDO:0002108	thyroid cancer	up-regulated	RT-qPCR	"CircRTN1 is up-regulated in thyroid cancer tissues and cells and is associated with lymph node metastasis and TNM stage. Functionally, circRTN1 promotes TC cell proliferation, migration, invasion, and xenograft tumor growth while suppressing apoptosis. Mechanistically, it acts as a sponge for miR-431-5p to upregulate TGFA through the circRTN1/miR-431-5p/TGFA axis."	0.8298
35809112	Biochemical genetics	2023	Circ-BICC1 Knockdown Alleviates Lipopolysaccharide (LPS)-Induced WI-38 Cell Injury Through miR-338-3p/MYD88 Axis.	hsa_circ_0018429	circ-BICC1 	hsa_circ_BICC1	BICC1	infantile pneumonia 	MONDO:0005249	pneumonia	up-regulated	RT-qPCR	"This study found that circ-BICC1 is up-regulated in blood samples from infantile pneumonia patients and in LPS-treated WI-38 cells. Functionally, circ-BICC1 knockdown alleviates LPS-induced cell injury by improving viability and proliferation while reducing apoptosis, inflammation, and oxidative stress. Mechanistically, circ-BICC1 acts as a miR-338-3p sponge to regulate MYD88, forming a circ-BICC1/miR-338-3p/MYD88 axis that promotes pneumonia progression."	0.7416
35817886	Biochemical genetics	2023	CircRNA-PTPRA Knockdown Inhibits Atherosclerosis Progression by Repressing ox-LDL-Induced Endothelial Cell Injury via Sponging of miR-671-5p.		circRNA-PTPRA	hsa_circ_PTPRA	PTPRA	Atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"circRNA-PTPRA is upregulated in the serum of AS patients and in ox-LDL-treated HUVECs. It promotes ox-LDL-induced endothelial cell injury by sponging miR-671-5p, while circRNA-PTPRA knockdown restores miR-671-5p, improves cell viability, reduces apoptosis, and suppresses inflammatory cytokine secretion."	0.7032
35821283	Cancer gene therapy	2022	Circ-GSK3B up-regulates GSK3B to suppress the progression of lung adenocarcinoma.	hsa_circ_0066903	circ-GSK3B	hsa_circ_GSK3B	GSK3B	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; Microarray	"circ-GSK3B (hsa_circ_0066903) is down-regulated in LUAD tissues and cells and functions as a tumor suppressor. It sponges miR-3681-3p and miR-3909 to increase GSK3B expression, and also binds FKBP51 to prevent FKBP51-GSK-3beta interaction, thereby inhibiting GSK-3beta S9 phosphorylation and inactivating Wnt/beta-catenin signaling. Functionally, circ-GSK3B suppresses LUAD proliferation, migration, EMT, stemness, tumor growth, and metastasis."	0.8711
35844005	Cell biology and toxicology	2023	Exosomes loaded with circPARD3 promotes EBV-miR-BART4-induced stemness and cisplatin resistance in nasopharyngeal carcinoma side population cells through the miR-579-3p/SIRT1/SSRP1 axis.		CircPARD3 	hsa_circ_PARD3	PARD3	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"This study reports that circPARD3 is up-regulated in nasopharyngeal carcinoma tissues and cell lines, and high expression is associated with shorter patient survival. Exosome-loaded circPARD3 promotes EBV-miR-BART4-induced stemness and cisplatin resistance in NPC-SP cells by regulating the miR-579-3p/SIRT1/SSRP1 axis, enhancing proliferation, migration, invasion, tumorsphere formation, and SP-cell features."	0.8148
35849320	Neurotoxicity research	2022	"Circ_0060055 Promotes the Growth, Invasion, and Radioresistance of Glioblastoma by Targeting MiR-197-3p/API5 Axis."	hsa_circ_0060055	Circ_0060055 	hsa_circ_EIF6	EIF6	glioblastoma 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; RNA-seq	"circ_0060055 is up-regulated in GBM tumor tissues and cells. It promotes GBM proliferation, invasion, tumor growth, and radioresistance while suppressing apoptosis, mainly by sponging miR-197-3p to positively regulate API5. The study suggests circ_0060055 as a potential therapeutic target for GBM and radiosensitization."	0.8443
35856314	Clinical and experimental pharmacology & physiology	2022	Hsa_circ_0097922 promotes tamoxifen resistance and cell malignant behaviour of breast cancer cells by regulating ACTN4 expression via miR-876-3p.	hsa_circ_0097922	Circ_0097922	hsa_circ_PGAM5	PGAM5	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0097922 is up-regulated in breast cancer tissues and tamoxifen-resistant breast cancer cells. It promotes malignant phenotypes and tamoxifen resistance by sponging miR-876-3p and increasing ACTN4 expression, while its knockdown sensitizes resistant cells and xenograft tumors to tamoxifen."	0.8572
35861544	Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology	2022	CircRNA circ_0005273 contributes to the cisplatin resistance of cervical cancer cells by sponging miR-133b.	hsa_circ_0005273	circ_0005273	hsa_circ_PTK2	PTK2	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ_0005273 is upregulated in cisplatin-resistant cervical cancer tissues and DDP-resistant HeLa/DDP and SiHa/DDP cells. It promotes cisplatin resistance by sponging miR-133b, supporting cell proliferation and suppressing apoptosis; high circ_0005273 expression is associated with FIGO stage, DDP status and poorer overall survival."	0.8078
35863454	Experimental cell research	2022	The malignant property of circHIPK2 for angiogenesis and chemoresistance in non-small cell lung cancer.		circular RNA HIPK2 	hsa_circ_HIPK2	HIPK2	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circHIPK2 is up-regulated in NSCLC, especially DDP-resistant NSCLC, and high expression is associated with poor overall survival, lymph node metastasis, and advanced TNM stage. Functionally, circHIPK2 promotes DDP chemoresistance, malignant behaviors, angiogenesis, and xenograft growth. Mechanistically, cytoplasmic circHIPK2 sponges miR-1249-3p to upregulate VEGFA."	0.8712
35870038	Cell biology and toxicology	2023	Circ_0004676 exacerbates triple-negative breast cancer progression through regulation of the miR-377-3p/E2F6/PNO1 axis.	hsa_circ_0004676		hsa_circ_ADAM22	ADAM22	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; Northern Blot; ISH	"This study reports that circ_0004674 is up-regulated in TNBC tissues and cell lines and that high expression predicts poor OS and DFS. Functionally, circ_0004674 promotes TNBC proliferation, cell cycle progression, migration, invasion, tumor growth, and metastasis. Mechanistically, it acts as a miR-377-3p sponge to increase E2F6 and downstream PNO1 expression, promoting p53 ubiquitination/degradation and TNBC progression."	0.8867
35875943	Animal biotechnology	2023	"Identification, biogenesis, and function prediction of a novel circRNA_3238 of chicken."		circRNA_3238	gga_circ_Foxp1	Foxp1	Avian Leukosis Virus 	MONDO:0025381	avian leukosis	down-regulated	RNA-seq	"circRNA_3238 is a chicken Foxp1-derived exonic circular RNA that is significantly down-regulated after ALV-J infection according to RNA-seq screening. The study experimentally confirmed its circular structure, stability and cytoplasmic localization, and bioinformatics analysis suggested that it may regulate ALV-J infection through a circRNA-miRNA-mRNA ceRNA network involving MAPK, Notch and immune-related pathways."	0.6149
35876160	Autoimmunity	2022	Berberine inhibits the development of endometrial cancer through circ_ZNF608/miR-377-3p/COX2 axis.		circ_ZNF608	hsa_circ_ZNF608	ZNF608	Endometrial carcinoma 	MONDO:0002447	endometrial carcinoma	up-regulated	RT-qPCR	"circ_ZNF608 is up-regulated in endometrial carcinoma cells and is down-regulated by berberine treatment. Functionally, circ_ZNF608 counteracts berberine-mediated suppression of EC cell proliferation, migration, invasion and EMT, while reducing apoptosis. Mechanistically, it sponges miR-377-3p to promote COX2 expression, forming a circ_ZNF608/miR-377-3p/COX2 axis associated with EC progression and poorer survival."	0.8354
35876480	"Cell cycle (Georgetown, Tex.)"	2022	Circ_0057452 sponges miR-7-5p to promote keloid progression through upregulating GAB1.	hsa_circ_0057452	circ_0057452	hsa_circ_COL5A2	COL5A2	keloid	MONDO:0005348	keloid	up-regulated	RT-qPCR	"circ_0057452 is upregulated in human keloid tissues and keloid fibroblasts. It promotes keloid fibroblast proliferation, migration, invasion, collagen synthesis, and cell cycle progression while inhibiting apoptosis. Mechanistically, circ_0057452 sponges miR-7-5p to positively regulate GAB1 expression, forming a circ_0057452/miR-7-5p/GAB1 axis that may represent a therapeutic target for keloid."	0.8119
35880619	Autoimmunity	2022	"Circ_0005714/miR-223-3p/ADAM9 regulatory axis affects proliferation, migration, invasion, and angiopoiesis in trophoblast cells."	hsa_circ_0005714	Circ_0005714	hsa_circ_SFXN1	SFXN1	preeclampsia 	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR	"circ_0005714 is up-regulated in PE placental tissues and experimentally validated by RT-qPCR. In trophoblast cells, circ_0005714 overexpression suppresses proliferation, migration, invasion, and angiopoiesis, contributing to PE-related trophoblast dysfunction. Mechanistically, circ_0005714 sponges miR-223-3p to increase ADAM9 expression and inhibit Wnt/beta-catenin signaling."	0.8189
35881155	Experimental brain research	2022	Circ_0049472 regulates the damage of Abeta-induced SK-N-SH and CHP-212 cells by mediating the miR-107/KIF1B axis.	hsa_circ_0049472	circ_0049472	hsa_circ_PRKCSH	PRKCSH	Alzheimer's disease 	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR	"circ_0049472 is up-regulated in CSF and serum from AD patients and in Abeta-induced SK-N-SH and CHP-212 cell models. It promotes Abeta-induced neurotoxicity by sponging miR-107 and increasing KIF1B expression, leading to reduced cell viability and increased apoptosis, inflammation and oxidative stress. Silencing circ_0049472 alleviates these AD-like cellular injuries, suggesting therapeutic potential."	0.7936
35881289	Environmental science and pollution research international	2022	CircP50 functions through the phosphorylation- and acetylation-activated p53 pathway to mediate inorganic arsenic-induced apoptosis in A549 cells.	hsa_circ_0008012	circP50	hsa_circ_NFKB1		lung cancer 	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	This study reports that circP50/hsa_circ_0008012 is up-regulated in A549 lung adenocarcinoma cells after inorganic arsenic exposure. Functional knockdown experiments indicate that circP50 suppresses A549 cell proliferation and supports arsenic-induced apoptosis mainly through activation of p53 phosphorylation and acetylation and downstream p53 target genes.	0.414
35900666	Molecular and cellular biochemistry	2023	"A novel identified circular RNA, circSnap47, promotes heart failure progression via regulation of miR-223-3p/MAPK axis."		circSnap47 	hsa_circ_SNAP47	Snap47	heart failure 	MONDO:0005252	heart failure	up-regulated	RT-qPCR; Microarray	"circSnap47 is up-regulated in heart failure-related datasets/tissues and in OGD-induced H9C2 cardiomyocytes. Functional knockdown experiments indicate that circSnap47 promotes OGD-induced cardiomyocyte injury, apoptosis, and inflammation. Mechanistically, circSnap47 acts through miR-223-3p and the MAPK signaling pathway, suggesting potential therapeutic relevance in HF."	0.5607
35900705	Biochemical genetics	2023	"A Circular RNA, hsa_circ_0018180 (circPARD3), Triggers Glycolysis and Promotes Malignancy of Head and Neck Squamous Cell Carcinoma Through the miR-5194/ENO1 Axis."	hsa_circ_0018180	circPARD3 	hsa_circ_PARD3	PARD3	head and neck squamous cell carcinoma 	MONDO:0010150	head and neck squamous cell carcinoma	up-regulated	RT-qPCR	"hsa_circ_0018180/circPARD3 is up-regulated in HNSCC tissues and cell lines, and high expression predicts poorer overall survival. Functionally, circPARD3 promotes HNSCC cell proliferation, migration, invasion, EMT-associated changes, and glycolysis. Mechanistically, it acts as a cytoplasmic miR-5194 sponge to increase ENO1 expression, forming a circPARD3/miR-5194/ENO1 ceRNA axis."	0.8562
35901982	Experimental hematology	2022	Rapamycin inhibits the progression of human acute myeloid leukemia by regulating the circ_0094100/miR-217/ATP1B1 axis.	hsa_circ_0094100	circRNA_0094100 			acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"circ_0094100 is upregulated in AML bone marrow samples and AML cell lines, while rapamycin treatment reduces its expression. Functionally, circ_0094100 supports AML cell viability and cell cycle progression and suppresses apoptosis; its knockdown enhances the anti-AML effects of rapamycin. Mechanistically, circ_0094100 sponges miR-217 to positively regulate ATP1B1 within the circ_0094100/miR-217/ATP1B1 axis."	0.7032
35904110	Autoimmunity	2022	"Knockdown of circ_0025908 inhibits proliferation, migration, invasion, and inflammation while stimulates apoptosis in fibroblast-like synoviocytes by regulating miR-650-dependent SCUBE2."	hsa_circ_0025908	hsa_ circRNA_0025908 	hsa_circ_PPHLN1	PPHLN1	rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"circ_0025908 is up-regulated in synovial tissues and FLS from RA patients and is associated with RA disease activity markers. Functionally, circ_0025908 promotes FLS-RA proliferation, migration, invasion, inflammation and cell cycle progression while suppressing apoptosis. Mechanistically, it sponges miR-650 to positively regulate SCUBE2, forming a circ_0025908/miR-650/SCUBE2 axis with potential therapeutic relevance in RA."	0.7524
35907138	Human cell	2022	Circular RNA circPBX3 promotes cisplatin resistance of ovarian cancer cells via interacting with IGF2BP2 to stabilize ATP7A mRNA expression.	hsa_circ_0004804	circPBX3	hsa_circ_PBX3	PBX3	ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; RNA-seq	"circPBX3/hsa_circ_0004804 is upregulated in ovarian cancer tissues and cisplatin-resistant ovarian cancer cells. It promotes cisplatin resistance by interacting with IGF2BP2 to stabilize ATP7A mRNA and increase ATP7A protein expression, thereby increasing cisplatin tolerance and reducing apoptosis under cisplatin treatment."	0.8445
35913598	Applied biochemistry and biotechnology	2022	High Glucose-Induced Human Kidney Cell Apoptosis and Inflammatory Injury Are Alleviated by Circ_0008529 Knockdown via Circ_0008529-Mediated miR-485-5p/WNT2B Signaling.	hsa_circ_0008529	circ_0008529 	hsa_circ_ACTR2	ACTR2	diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"Circ_0008529/hsa_circ_0008529 is up-regulated in serum from diabetic nephropathy patients and in high-glucose-treated HK-2 cells. Its knockdown alleviates high glucose-induced renal tubular cell injury by improving viability and reducing apoptosis and inflammatory cytokine release. Mechanistically, circ_0008529 sponges miR-485-5p to increase WNT2B expression, forming a circ_0008529/miR-485-5p/WNT2B regulatory axis."	0.778
35917008	Biochemical genetics	2023	Circ_0035381 Regulates Acute Myeloid Leukemia Development by Modulating YWHAZ Expression via Adsorbing miR-582-3p.	hsa_circ_0035381	circ_0035381	hsa_circ_PIGB	PIGB	Acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"Circ_0035381 is upregulated in AML bone marrow samples and AML cells. Functionally, circ_0035381 promotes AML cell proliferation, cell cycle progression, autophagy, and in vivo tumor growth while suppressing apoptosis and mitochondrial damage. Mechanistically, it sponges miR-582-3p to increase YWHAZ expression, forming a circ_0035381/miR-582-3p/YWHAZ regulatory axis that contributes to AML progression."	0.7591
35920438	Journal of biochemical and molecular toxicology	2022	Circ-CBFB exacerbates hypoxia/reoxygenation-triggered cardiomyocyte injury via regulating miR-495-3p in a VDAC1-dependent manner.		circ-CBFB	rno_circ_CBFB	CBFB	acute myocardial infarction 	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR	"circ-CBFB is up-regulated in H/R-injured H9c2 cardiomyocytes and acts as a detrimental regulator of cardiomyocyte injury. Its knockdown protects cells by improving viability, inhibiting apoptosis and oxidative stress, and alleviating mitochondrial dysfunction. Mechanistically, circ-CBFB sponges miR-495-3p to increase VDAC1 expression, forming a circ-CBFB/miR-495-3p/VDAC1 axis relevant to myocardial I/R injury and AMI management."	0.627
35920610	"Cell cycle (Georgetown, Tex.)"	2022	Circ_0001955 promotes the progression of non-small cell lung cancer via miR-769-5p/EGFR axis.	hsa_circ_0001955	circular RNA 0001955 			non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0001955 is up-regulated in NSCLC tissues and cell lines and is associated with advanced TNM stage and lymph node metastasis. Functionally, circ_0001955 promotes proliferation, migration and cell cycle progression while inhibiting apoptosis in NSCLC cells. Mechanistically, cytoplasmic circ_0001955 acts as a ceRNA that sponges miR-769-5p and indirectly upregulates EGFR expression to facilitate NSCLC progression."	0.73
35920698	"Cell cycle (Georgetown, Tex.)"	2022	Circular RNA circFARSA promotes the tumorigenesis of non-small cell lung cancer by elevating B7H3 via sponging miR-15a-5p.	hsa_circ_0000896	circFARSA 	hsa_circ_FARSA	FARSA	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circFARSA/hsa_circ_0000896 is upregulated in NSCLC tissues and cell lines and high expression is associated with adverse clinicopathological features and poorer overall survival. Functionally, circFARSA promotes NSCLC cell proliferation, migration, invasion, tumor growth and metastasis. Mechanistically, it acts as a cytoplasmic sponge for miR-15a-5p to increase B7H3 expression, forming a circFARSA/miR-15a-5p/B7H3 oncogenic axis."	0.817
35924466	Current eye research	2022	Down-Regulation of circCOL1A2 Suppresses the Dysfunction of Diabetes-Related Retinal Microvascular Endothelial Cells via miR-646/FGF7 Axis.		circCOL1A2 	hsa_circ_COL1A2	COL1A2	Diabetic retinopathy 	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR	"circCOL1A2 is up-regulated in retinal tissues from DR patients and in HG-treated human RMECs. It promotes HG-induced endothelial dysfunction, including migration, proliferation, angiogenesis, BRB injury and inflammation, by acting as a miR-646 sponge and regulating FGF7. circCOL1A2 silencing is proposed as a potential therapeutic strategy for diabetic retinopathy."	0.7945
35925446	Metabolic brain disease	2023	Circ_0000011 promotes cerebral ischemia/reperfusion injury via miR-27a-3p-dependent regulation of NRIP1.	mmu_circ_0000011	circ_0000011 	mmu_circ_NCOA2	NCOA2	cerebral ischemia	MONDO:0002679	cerebral infarction	up-regulated	RT-qPCR	"This study reports that circ_0000011 is up-regulated in OGD/R-treated mouse HT-22 neuronal cells and promotes cerebral ischemia/reperfusion-like cell injury. Mechanistically, circ_0000011 sponges miR-27a-3p to regulate NRIP1, thereby promoting apoptosis and inflammation while suppressing proliferation; circ_0000011 knockdown is protective in this in vitro model."	0.7406
35930101	Cell biology and toxicology	2023	CircJag1 promotes apoptosis of ethylene thiourea-exposed anorectal malformations through sponging miR-137-3p by regulating Sox9 and suppressing Wnt/beta-catenin pathway during the hindgut development of rat embryos.		circJag1 	rno_circ_Jag1	Jag1	anorectal malformations 	MONDO:0001177	anorectal stricture	up-regulated	RT-qPCR; ISH; RNA-seq	"circJag1 is upregulated in ETU-induced rat embryonic ARM hindgut tissues. It promotes epithelial apoptosis and inhibits proliferation by sponging miR-137-3p, increasing Sox9, degrading nuclear beta-catenin, and suppressing canonical Wnt/beta-catenin signaling, thereby contributing to failed urorectal septum and cloacal membrane fusion in anorectal malformations."	0.8386
35939970	"Pathology, research and practice"	2022	Hsa_circ_0102485 inhibits the growth of cancer cells by regulating the miR-188-3p/ARID5B/AR axis in prostate carcinoma.	hsa_circ_0102485		hsa_circ_ZFYVE26	ZFYVE26	prostate carcinoma 	MONDO:0005159	prostate carcinoma	down-regulated	RT-qPCR; ISH	"Hsa_circ_0102485 is downregulated in prostate carcinoma tissues and cell lines and functions as a tumor suppressor. It sponges miR-188-3p to upregulate ARID5B and AR, thereby inhibiting PCa cell proliferation, migration, invasion, antiapoptotic capacity, and xenograft tumor growth. The study suggests hsa_circ_0102485 may have diagnostic and therapeutic potential, although no significant correlation with measured clinicopathological characteristics was found."	0.7373
35943044	"Journal of chemotherapy (Florence, Italy)"	2023	Luteolin suppresses lung cancer progression through targeting the circ_0000190/miR-130a-3p/notch-1 signaling pathway.	hsa_circ_0000190	circ_0000190			lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circ_0000190 is up-regulated in lung cancer and functions as a pro-tumor circRNA in this study. It binds miR-130a-3p and modulates the Notch-1 signaling pathway, promoting lung cancer cell growth, migration, invasion and tumor growth while reducing apoptosis; luteolin suppresses lung cancer partly by downregulating circ_0000190."	0.6276
35945269	Laboratory investigation; a journal of technical methods and pathology	2022	CircRNA-ST6GALNAC6 increases the sensitivity of bladder cancer cells to erastin-induced ferroptosis by regulating the HSPB1/P38 axis.	hsa_circ_0088708	CircRNA-ST6GALNAC6 	hsa_circ_ST6GALNAC6	ST6GALNAC6	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"circST6GALNAC6 is reduced in bladder cancer tissues and higher expression is associated with better patient survival. Functionally, circST6GALNAC6 enhances erastin-induced ferroptosis in bladder cancer cells and xenografts by binding the N-terminus of HSPB1, blocking Ser-15 phosphorylation, and regulating the HSPB1/p38 MAPK axis. The study proposes circST6GALNAC6 as a potential therapeutic target and biomarker of ferroptosis sensitivity in bladder cancer."	0.7976
35957556	Oral diseases	2023	Down-regulation of hsa-circ-0107593 promotes osteogenic differentiation of hADSCs via miR-20a-5p/SMAD6 signaling.	hsa_circ_0107593	hsa-circ-0107593			skull defect 	MONDO:0005381	bone disorder	down-regulated	RT-qPCR	"This study shows that hsa-circ-0107593 is downregulated during hADSC osteogenic differentiation and functions as a negative regulator of osteogenesis. Mechanistically, hsa-circ-0107593 sponges miR-20a-5p to relieve repression of SMAD6, and its knockdown promotes osteogenic differentiation and bone formation in a nude mouse skull defect model. The hsa-circ-0107593/miR-20a-5p/SMAD6 axis is proposed as a potential therapeutic strategy for skull defect repair."	0.7693
35960441	Molecular biotechnology	2023	CircSHOC2 Knockdown Alleviates High Glucose-Induced Vascular Endothelial Cell Pyroptosis via Targeting miR-145/FOXO1 Axis In Vitro Condition.	hsa_circ_0000261	circSHOC2 	hsa_circ_SHOC2	SHOC2	cardiovascular system complications of diabetes 	MONDO:0005015	diabetes mellitus	up-regulated	RT-qPCR; Microarray	"circSHOC2 is up-regulated in high glucose-induced HUVECs and contributes to vascular endothelial cell pyroptosis. Silencing circSHOC2 restores proliferation and reduces pyroptosis markers and inflammatory cytokines. Mechanistically, circSHOC2 functions as a miR-145 sponge to regulate FOXO1 through the circSHOC2/miR-145/FOXO1 axis."	0.7884
35964907	Annals of hepatology	2022	Circ_0008285 knockdown represses tumor development by miR-384/RRM2 axis in hepatocellular carcinoma.	hsa_circ_0008285	circ_0008285 	hsa_circ_CDYL	CDYL	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0008285 is up-regulated in HCC tissues and cell lines and functions as an oncogenic circRNA. Its knockdown suppresses proliferation, migration, invasion, EMT and xenograft tumor growth while promoting apoptosis, mainly through sponging miR-384 to increase RRM2 expression. The study suggests circ_0008285 may be a diagnostic/treatment marker and therapeutic target for HCC."	0.73
35970245	Toxicology in vitro : an international journal published in association with BIBRA	2022	Circ_0005758 impedes gastric cancer progression through miR-1229-3p/GCNT4 feedback loop.	hsa_circ_0005758	Circ_0005758	hsa_circ_KIAA0907	KIAA0907	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"Circ_0005758 is down-regulated in gastric cancer tissues and cells and acts as a tumor suppressor. Its overexpression inhibits proliferation, migration, invasion, angiogenesis, and xenograft tumor growth while promoting apoptosis. Mechanistically, circ_0005758 sponges miR-1229-3p to increase GCNT4 expression, forming a circ_0005758/miR-1229-3p/GCNT4 ceRNA axis."	0.7552
35972691	Journal of cancer research and clinical oncology	2023	Circulating circular RNA hsa_circ_0023179 acts as a diagnostic biomarker for non-small-cell lung cancer detection.	hsa_circ_0023179		hsa_circ_LRP5	LRP5	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0023179 is a human LRP5-derived circRNA that is up-regulated in NSCLC tissues, serum, and cell lines. The study supports its use as a circulating diagnostic biomarker with better diagnostic performance than conventional serum markers and shows association with advanced clinicopathological features, postoperative monitoring potential, and poor prognosis. Mechanistically, it is mainly cytoplasmic and was predicted to participate in a circRNA-miRNA-mRNA regulatory network, but its biological regulatory role remains largely unvalidated."	0.7417
35976517	Journal of bioenergetics and biomembranes	2022	CircZNF644 aggravates lipopolysaccharide-induced HK-2 cell impairment via the miR-140-5p/MLKL axis.	hsa_circ_0114427	 circ-ZNF644	hsa_circ_ZNF644	ZNF644	acute kidney injury 	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR	"CircZNF644 is up-regulated in LPS-stimulated HK-2 cells, an in vitro septic AKI model. Functionally, circZNF644 aggravates LPS-induced cell injury by suppressing proliferation and cell cycle progression while promoting apoptosis and inflammatory cytokine production. Mechanistically, circZNF644 sponges miR-140-5p to regulate MLKL, forming a circZNF644/miR-140-5p/MLKL axis that may represent a therapeutic target for AKI."	0.763
35980117	Expert review of hematology	2022	"CircPTK2 promotes cell viability, cell cycle process, and glycolysis and inhibits cell apoptosis in acute myeloid leukemia by regulating miR-582-3p/ALG3 axis."	hsa_circ_0002483	 circPTK2	hsa_circ_PTK2	PTK2	acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"CircPTK2 is upregulated in AML peripheral blood samples and AML cell lines. Functionally, circPTK2 promotes AML cell viability, proliferation, cell cycle progression and glycolysis while suppressing apoptosis. Mechanistically, it acts as a sponge for miR-582-3p to positively regulate ALG3 expression, forming a circPTK2/miR-582-3p/ALG3 axis that contributes to AML malignant behaviors."	0.7045
35984539	Biochemical genetics	2023	Circ_0004712 Silencing Suppresses the Aggressive Changes of Rheumatoid Arthritis Fibroblast-Like Synoviocytes by Targeting miR-633/TRAF6 Axis.	hsa_circ_0004712	Circular RNA_0004712 	hsa_circ_PDE7B	PDE7B	rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"circ_0004712 is up-regulated in RA synovial tissues and RA-FLSs. Functionally, it promotes RA-FLS viability, proliferation, migration and inflammatory cytokine release while suppressing apoptosis. Mechanistically, circ_0004712 sponges miR-633 to increase TRAF6 expression and activate NF-kappaB signaling, supporting its potential as an RA therapeutic target."	0.7595
35986866	International urology and nephrology	2023	The novel biomarker circ_0020339 drives septic acute kidney injury by targeting miR-17-5p/IPMK axis.	hsa_circ_0020339	circ_0020339			septic acute kidney injury 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR; Microarray	"circ_0020339 is up-regulated in plasma from septic AKI patients and in LPS-induced HK2 cells and mice. It promotes renal injury, inflammation and apoptosis through the miR-17-5p/IPMK axis and downstream TRAF6/AKT/NF-kappaB-related signaling, while its knockdown alleviates LPS-induced septic AKI phenotypes. Plasma circ_0020339 also shows diagnostic value for septic AKI."	0.7759
35993243	Autoimmunity	2022	CircSCAPER knockdown attenuates IL-1beta-induced chondrocyte injury by miR-127-5p/TLR4 axis in osteoarthritis.		circSCAPER 	hsa_circ_SCAPER	SCAPER	Osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circSCAPER is up-regulated in OA cartilage and IL-1beta-treated human chondrocytes. It promotes OA-like chondrocyte dysfunction by sponging miR-127-5p and increasing TLR4 expression, thereby facilitating apoptosis, ECM degradation, inflammation and oxidative damage. circSCAPER knockdown may represent a potential therapeutic strategy for OA."	0.7244
35993263	Scandinavian journal of gastroenterology	2022	Potentials of circSOBP in the diagnosis and prognosis of gastric cancer.		circSOBP	hsa_circ_SOBP	SOBP	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"This clinical study found that circSOBP is down-regulated in gastric cancer plasma and tissue samples. Plasma circSOBP showed diagnostic potential for distinguishing GC patients from patients with IBS, GERD, gastritis, PU and healthy controls, while higher plasma or tissue circSOBP levels were associated with better survival. The study did not experimentally define a molecular mechanism in GC, but circSOBP levels were closely associated with tumor metastasis."	0.5918
35994105	Mammalian genome : official journal of the International Mammalian Genome Society	2022	Silencing circ_0074371 inhibits the progression of sepsis-induced acute kidney injury by regulating miR-330-5p/ELK1 axis.	hsa_circ_0074371	circ_0074371	hsa_circ_ARHGAP26	ARHGAP26	sepsis-induced acute kidney injury 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR; RNA-seq	"circ_0074371 is up-regulated in septic AKI patient serum and LPS-induced HK2 cells. Its knockdown alleviates LPS-induced HK2 cell injury by improving viability and suppressing apoptosis, inflammation and oxidative stress. Mechanistically, circ_0074371 sponges miR-330-5p to increase ELK1 expression, forming a circ_0074371/miR-330-5p/ELK1 axis."	0.7404
35994229	Molecular biotechnology	2023	Circ_0001982 Up-regulates the Expression of E2F1 by Adsorbing miR-1205 to Facilitate the Progression of Glioma.	hsa_circ_0001982	circ_0001982 	hsa_circ_RNF11	RNF11	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR; Microarray	"Circ_0001982 is up-regulated in glioma tissues and cell lines and its high expression is associated with larger tumor size. Functionally, it promotes glioma cell proliferation, migration, invasion, and cell cycle progression. Mechanistically, cytoplasmic circ_0001982 sponges miR-1205 to relieve repression of E2F1, forming a circ_0001982/miR-1205/E2F1 regulatory axis that accelerates glioma progression."	0.742
35995117	Gene	2022	Construction of circRNA-associated ceRNA network reveals the regulation of fibroblast proliferation in cervical cancer.		circZNF208 	hsa_circ_ZNF208	ZNF208	cervical cancer 	MONDO:0002974	cervical cancer	down-regulated	RNA-seq	"circZNF208 is a novel circRNA identified by circRNA-seq as down-regulated in cervical cancer tissues compared with adjacent tissues. The study proposes that circZNF208 participates in a ceRNA network, especially the circ_ZNF208/hsa-miR-342-3p/LPHN3 axis, and may promote fibroblast proliferation and influence tumor-associated fibroblast-related prognosis in cervical cancer."	0.3991
35998761	Cellular signalling	2022	Circ_0007624 suppresses the development of esophageal squamous cell carcinoma via targeting miR-224-5p/CPEB3 to inactivate the EGFR/PI3K/AKT signaling.	hsa_circ_0007624	circ_0007624	hsa_circ_BCAR3	BCAR3	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	"circ_0007624 is down-regulated in ESCC and low expression predicts worse survival. It functions as a tumor suppressor by sponging miR-224-5p, increasing CPEB3 expression, and inactivating EGFR/PI3K/AKT signaling, thereby inhibiting proliferation, metastasis and EMT while promoting apoptosis."	0.8921
35998761	Cellular signalling	2022	Circ_0007624 suppresses the development of esophageal squamous cell carcinoma via targeting miR-224-5p/CPEB3 to inactivate the EGFR/PI3K/AKT signaling.	hsa_circ_0083943	circ_0083943			esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	"circ_0083943 was identified from GEO datasets as an overlapping down-regulated circRNA in ESCC and was validated by qRT-PCR in a small clinical sample set. The study did not further analyze its mechanism, function, prognostic value or interaction partners."	0.4032
36001185	Biochemical genetics	2023	Circ_0008717 Sponges miR-326 to Elevate GATA6 Expression to Promote Breast Cancer Tumorigenicity.	hsa_circ_0008717	Circ_0008717	hsa_circ_ABCB10		breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0008717 is up-regulated in breast cancer tissues and cells and high expression is associated with shorter overall survival. It functions as an oncogenic cytoplasmic ceRNA by sponging miR-326, thereby elevating GATA6 expression to promote proliferation, angiogenesis, migration, invasion, EMT, tumor growth and metastasis while suppressing apoptosis."	0.8354
36002666	Biochemical genetics	2023	Circ_HIPK3 Inhibits H2O2-Induced Lens Epithelial Cell Injury in Age-Related Cataract Depending on the Regulation of miR-495-3p/HDAC4 Pathway.		circ_HIPK3 	hsa_circ_HIPK3	HIPK3	age-related cataract 	MONDO:0004847	senile cataract	down-regulated	RT-qPCR	"circ_HIPK3 is down-regulated in ARC tissues and H2O2-induced human lens epithelial SRA01/04 cells. Functionally, circ_HIPK3 overexpression alleviates H2O2-induced lens epithelial cell injury by promoting proliferation and suppressing apoptosis and fibrosis. Mechanistically, circ_HIPK3 sponges miR-495-3p to positively regulate HDAC4, forming a circ_HIPK3/miR-495-3p/HDAC4 axis with potential therapeutic relevance for ARC."	0.6479
36004511	"Hematology (Amsterdam, Netherlands)"	2022	Hsa_circ_0044907 promotes acute myeloid leukemia progression through upregulating oncogene KIT via sequestering miR-186-5p.	hsa_circ_0044907	circ_0044907	hsa_circ_RPS6KB1	RPS6KB1	acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"hsa_circ_0044907/circ_0044907 is up-regulated in AML patient BM and AML cells and is associated with diagnostic value and poor overall survival. Functionally, it promotes AML cell growth, proliferation and cell cycle progression while suppressing apoptosis, partly through sponging miR-186-5p to upregulate KIT. Knockdown of circ_0044907 reduces AML xenograft growth in vivo."	0.8423
36004524	"Hematology (Amsterdam, Netherlands)"	2022	Circ_0003489 facilitates multiple myeloma progression by targeting miR-433-3p/PBX3 axis.	hsa_circ_0003489	circular RNA_0003489 	hsa_circ_CDK8	CDK8	Multiple myeloma 	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR	"circ_0003489 is up-regulated in MM tissues and cells and mainly localized in the cytoplasm. It promotes MM cell progression by sponging miR-433-3p and thereby positively regulating PBX3, leading to enhanced proliferation and cell cycle progression and reduced apoptosis. Its expression is associated with several clinicopathological characteristics and it is proposed as a potential therapeutic target for MM."	0.7795
36008700	Biochemical genetics	2023	"CircSOD2 Contributes to Tumor Progression, Immune Evasion and Anti-PD-1 Resistance in Hepatocellular Carcinoma by Targeting miR-497-5p/ANXA11 Axis."	hsa_circ_0004662	circRNA superoxide dismutase 2 	hsa_circ_SOD2	SOD2	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"CircSOD2 is upregulated in HCC tissues and cell lines and functions as an oncogenic circRNA. It promotes HCC growth, metastasis, immune evasion and anti-PD-1 resistance by sponging miR-497-5p and increasing ANXA11 expression. Its high expression is associated with reduced CD8 + T cell frequency and potential immunotherapeutic resistance."	0.8572
36018460	"Reproductive sciences (Thousand Oaks, Calif.)"	2023	Circ_0042986 Presence Restrains Cervical Cancer Development via Upregulating PEG3 by Directly Targeting miR-582-3p.	hsa_circ_0042986	circ_0042986	hsa_circ_SUZ12	SUZ12	cervical cancer 	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR; RNA-seq	"Circ_0042986 is downregulated in cervical cancer tissues and cells. Restoring circ_0042986 suppresses malignant phenotypes and tumor growth by sponging miR-582-3p and increasing PEG3 expression, supporting its role as a tumor-suppressive circRNA and potential therapeutic option in cervical cancer."	0.8006
36029209	Environmental toxicology	2022	Circ_SNX27 regulates hepatocellular carcinoma development via miR-637/FGFR1 axis.	hsa_circ_0000130	circ_SNX27	hsa_circ_SNX27	SNX27	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"Circ_SNX27 is up-regulated in human HCC tissues and cell lines and mainly localizes to the cytoplasm. It functions as an oncogenic circRNA by promoting proliferation, migration, invasion, EMT-related marker changes, and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ_SNX27 sponges miR-637 to increase FGFR1 expression, forming a circ_SNX27/miR-637/FGFR1 regulatory axis."	0.8175
36039693	The International journal of neuroscience	2024	Circ_0001360 absence alleviates oxygen-glucose deprivation/reoxygenation-induced SK-N-SH cell injury via controlling the miR-671-5p/BMF pathway.	hsa_circ_0001360	circ_0001360	hsa_circ_PHC3	PHC3	ischemic stroke 	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR	"In an in vitro ischemic stroke model, circ_0001360 was up-regulated in OGD/R-treated SK-N-SH cells and mainly localized in the cytoplasm. Functional assays showed that circ_0001360 knockdown alleviated OGD/R-induced proliferative impairment, apoptosis and inflammation. Mechanistically, circ_0001360 regulated the miR-671-5p/BMF axis and promoted NF-kappaB pathway activity."	0.7216
36052886	Environmental toxicology	2022	Downregulation of circ-ZNF644 alleviates LPS-induced HK2 cell injury via miR-335-5p/HIPK1 axis.	hsa_circ_0114428	circ-ZNF644	hsa_circ_ZNF644	ZNF644	sepsis-induced acute kidney injury 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR	"Circ-ZNF644 is up-regulated in serum from patients with sepsis-induced AKI and in LPS-treated renal epithelial cell models. Functionally, circ-ZNF644 promotes LPS-induced HK2 cell injury, including inflammation, oxidative stress and apoptosis, while suppressing proliferation. Mechanistically, circ-ZNF644 sponges miR-335-5p to regulate HIPK1, supporting the circ-ZNF644/miR-335-5p/HIPK1 axis as a potential therapeutic target in sepsis-induced AKI."	0.7591
36056285	Biochemical genetics	2023	Circ_0061140 Contributes to Ovarian Cancer Progression by Targeting miR-761/LETM1 Signaling.	hsa_circ_0061140	circ_0061140	hsa_circ_C20orf11	C20orf11	ovarian cancer	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"Circ_0061140 is up-regulated in ovarian cancer tissues and cell lines and is mainly cytoplasmic. It promotes ovarian cancer progression by sponging miR-761 to increase LETM1 expression, thereby enhancing proliferation, migration, invasion, angiogenesis, EMT and xenograft tumor growth while suppressing apoptosis. Its higher expression in stage III tissues suggests a potential association with more advanced disease."	0.8175
36063260	Biochemical genetics	2023	CircDUSP22 Overexpression Restrains Pancreatic Cancer Development via Modulating miR-1178-3p and Downstream BNIP3.	hsa_circ_0075410	circDUSP22 	hsa_circ_DUSP22	DUSP22	pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	down-regulated	RT-qPCR; RNA-seq	"circDUSP22/hsa_circ_0075410 is down-regulated in pancreatic cancer tissues and cell lines and is mainly localized in the cytoplasm. Its overexpression suppresses PaCa cell growth, induces cell-cycle arrest and apoptosis, and reduces xenograft tumor growth. Mechanistically, circDUSP22 sponges miR-1178-3p to upregulate BNIP3, supporting its potential as a therapeutic target in PaCa."	0.8256
36067529	"Nucleosides, nucleotides & nucleic acids"	2023	Circ_0000467 modulates malignant characteristics of colorectal cancer via sponging miR-651-5p and up-regulating DNMT3B.	hsa_circ_0000467	circ_0000467 	hsa_circ_SKA3	SKA3	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0000467 is up-regulated in colorectal cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes CRC cell growth, migration and invasion by sponging miR-651-5p, thereby increasing DNMT3B expression, and may serve as a potential diagnostic biomarker and therapeutic target."	0.7581
36071678	"Cell cycle (Georgetown, Tex.)"	2022	circRNA PLOD2 promotes tumorigenesis and Warburg effect in colon cancer by the miR-513a-5p/SIX1/LDHA axis.	hsa_circ_0122319	circPLOD2	hsa_circ_PLOD2	PLOD2	colon cancer	MONDO:0021063	malignant colon neoplasm	up-regulated	RT-qPCR	"circPLOD2 is upregulated in colon cancer tissues and cell lines and high expression is associated with poor overall survival. Functionally, circPLOD2 promotes proliferation, migration, invasion, tumor growth, and glycolytic/Warburg metabolism. Mechanistically, it sponges miR-513a-5p to activate SIX1, which enhances LDHA transcription and supports colon cancer progression."	0.8814
36071682	"Cell cycle (Georgetown, Tex.)"	2023	CircMAP3K4 protects human lens epithelial cells from H2O2-induced dysfunction by targeting miR-193a-3p/PLCD3 axis in age-related cataract.	hsa_circ_0078619	circMAP3K4	hsa_circ_MAP3K4	MAP3K4	age-related cataract 	MONDO:0004847	senile cataract	down-regulated	RT-qPCR	"CircMAP3K4 (hsa_circ_0078619) is down-regulated in age-related cataract patient lens epithelium tissues and in H2O2-induced SRA01/04 human lens epithelial cells. Its overexpression protects cells from H2O2-induced dysfunction by promoting viability and proliferation while inhibiting senescence, apoptosis, and oxidative stress. Mechanistically, circMAP3K4 functions as a miR-193a-3p sponge to up-regulate PLCD3 in the circMAP3K4/miR-193a-3p/PLCD3 axis."	0.8107
36073553	Journal of biochemical and molecular toxicology	2022	"Circ_0123996 promotes the proliferation, inflammation, and fibrosis of mesangial cells by sponging miR-203a-3p to upregulate SOX6 in diabetic nephropathy."	hsa_circ_0123996	circ_0123996			diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"circ_0123996 is upregulated in high glucose-induced human mesangial cells, a cell model relevant to diabetic nephropathy. It promotes mesangial cell proliferation, inflammation, and fibrosis by sponging miR-203a-3p and thereby upregulating SOX6, suggesting a potential therapeutic target for DN progression."	0.5416
36089485	Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]	2022	STAM binding protein regulated by hsa_circ_0007334 exerts oncogenic potential in pancreatic cancer.	hsa_circ_0007334	hsa_-circ_0007334 			Pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"hsa_circ_0007334 is up-regulated in pancreatic cancer tissues and functions as an oncogenic circRNA. In this study, it promotes pancreatic cancer cell migration and invasion at least partly by regulating the miR-1272/STAMBP axis."	0.6369
36094501	"Hematology (Amsterdam, Netherlands)"	2022	CircNFIX knockdown inhibited AML tumorigenicity by the miR-876-3p/TRIM31 axis.		circNFIX 	hsa_circ_NFIX	NFIX	Acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"circNFIX is up-regulated in AML bone marrow samples and AML cell lines and may serve as a diagnostic biomarker. Functionally, circNFIX promotes AML cell proliferation and cell cycle progression while suppressing apoptosis. Mechanistically, circNFIX sponges miR-876-3p to up-regulate TRIM31 expression, forming a circNFIX/miR-876-3p/TRIM31 axis that supports AML progression."	0.7548
36103059	Biochemical genetics	2023	Circular RNA Circ_0001777 Suppresses Lung Adenocarcinoma Progression In Vitro and In Vivo.	hsa_circ_0001777	Circular RNA_0001777 	hsa_circ_ESYT2	ESYT2	lung adenocarcinoma	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR	"Circ_0001777 is down-regulated in lung adenocarcinoma tissues and cell lines, and low expression is associated with worse prognosis. Functionally, circ_0001777 acts as a tumor suppressor by inhibiting proliferation, migration, invasion, glycolysis and xenograft tumor growth while promoting apoptosis. Mechanistically, it sponges miR-942-5p to up-regulate PRICKLE2, forming a circ_0001777/miR-942-5p/PRICKLE2 regulatory axis; it can also be packaged into exosomes."	0.8656
36104590	Biochemical genetics	2023	CircLIFR Inhibits Non-small Cell Lung Cancer Progression by Acting as a miR-429 Sponge to Enhance CELF2 Expression.	hsa_circ_0072309	circLIFR	hsa_circ_LIFR	LIFR	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"circLIFR is downregulated in NSCLC and acts as a tumor suppressor. It functions as a miR-429 sponge to upregulate CELF2 and activate PTEN-related suppression of AKT signaling, thereby inhibiting proliferation, migration, invasion, and tumor growth while promoting apoptosis and cell-cycle arrest."	0.7769
36104951	Allergy	2023	circS100A11 enhances M2a macrophage activation and lung inflammation in children with asthma.	hsa_circ_0014208	circS100A11	hsa_circ_S100A11	S100A11	childhood asthma 	MONDO:0005405	childhood onset asthma	up-regulated	RT-qPCR; Microarray	"circS100A11 (hsa_circ_0014208), a human circRNA derived from S100A11, is up-regulated in PBMCs from children with asthma and is mainly expressed in monocytes. It promotes M2a macrophage activation and aggravates allergen-induced lung inflammation by binding CAPRIN1 to relieve translational repression of S100A11, thereby enhancing SP3/STAT6-mediated macrophage activation. Clinically, circS100A11 showed diagnostic potential and correlated positively with peripheral blood eosinophil numbers."	0.866
36109630	Oncogene	2022	Hsa_circ_0000437 promotes pathogenesis of gastric cancer and lymph node metastasis.	hsa_circ_0000437		hsa_circ_CORO1C	CORO1C	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000437 is a CORO1C-derived circRNA upregulated in gastric cancer tissues, cells and serum exosomes. It promotes GC tumorigenic phenotypes through the SRSF3/PDCD4 axis and promotes lymphangiogenesis and lymph node metastasis via exosomal transfer to HLECs and HSPA2-ERK signaling. Clinically, high serum exosomal hsa_circ_0000437 is associated with LNM and poor survival and may serve as a diagnostic/prognostic biomarker and therapeutic target."	0.8824
36111683	Scandinavian journal of gastroenterology	2023	The role of circular RNA hsa_circ_0001789 as a diagnostic biomarker in gastric carcinoma.	hsa_circ_0001789	hsa_-circ_0001789 	hsa_circ_RAB11FIP1	RAB11FIP1	gastric carcinoma 	MONDO:0004950	gastric carcinoma	down-regulated	RT-qPCR; Microarray	"This study identified hsa_circ_0001789 as a human circRNA derived from RAB11FIP1 and found it significantly down-regulated in gastric cancer tissues and plasma. Its reduced expression was associated with more aggressive clinicopathological characteristics, and ROC analysis supported its potential as a diagnostic biomarker for GC."	0.5047
36113315	International immunopharmacology	2022	Hsa_circ_0008301 as a potential biomarker of disease activity for primary Sjogren's syndrome: Increased expression in peripheral blood of patients with primary Sjogren's syndrome.	hsa_circ_0008301	hsa_-circ_0008301	hsa_circ_TOLLIP	TOLLIP	primary Sj_gren's syndrome 	MONDO:0010030	Sjogren syndrome	up-regulated	RT-qPCR	"This study found that hsa_circ_0008301 is up-regulated in peripheral blood from patients with pSS and is higher in patients with active disease. Its expression correlates with several clinical and laboratory indicators and decreases after treatment, supporting its potential use as a biomarker for pSS diagnosis, disease activity evaluation, and treatment response monitoring. The proposed mechanism is speculative and involves possible participation in pSS inflammation through the MyD88-dependent TLR-NF-kappaB pathway."	0.4187
36115894	Journal of endocrinological investigation	2023	Microarray profiling identifies hsa_circ_0082003 as a novel tumor promoter for papillary thyroid carcinoma.	hsa_circ_0082003		hsa_circ_MET	MET	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"This study identifies hsa_circ_0082003, a MET-derived circRNA, as an up-regulated oncogenic circRNA in papillary thyroid carcinoma. Its knockdown suppresses PTC cell proliferation, migration, invasion, and xenograft tumor growth, while high expression is associated with aggressive clinicopathological features and independently predicts lymph node metastasis. The exact downstream regulatory mechanism in PTC was not defined."	0.7369
36127411	Cancer gene therapy	2023	m6A-modified circFOXK2 targets GLUT1 to accelerate oral squamous cell carcinoma aerobic glycolysis.	hsa_circ_0000816	circFOXK2	hsa_circ_FOXK2	FOXK2	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circFOXK2 (hsa_circ_0000816), a FOXK2-derived m6A-modified circRNA, is up-regulated in OSCC cells. It acts as an oncogenic circRNA by promoting OSCC cell proliferation, migration, and aerobic glycolysis. Mechanistically, circFOXK2 cooperates with the m6A reader/RBP IGF2BP3 to enhance GLUT1 mRNA stability in a m6A-dependent manner, suggesting potential therapeutic relevance in OSCC."	0.7884
36153641	International journal of experimental pathology	2022	"Circular RNAs hsa_circ_0001438 and hsa_circ_0000417 are downregulated and upregulated, respectively, in hepatocellular carcinoma."	hsa_circ_0001438		hsa_circ_LARP1B	LARP1B	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001438 was identified from public RNA-seq data as downregulated in primary HCC tissues and was further confirmed by RT-qPCR to be lower in HCC cell lines than in normal hepatocytes. The study proposes hsa_circ_0001438 as a potential diagnostic biomarker for HCC, especially early-stage or nonviral HCC."	0.6193
36153641	International journal of experimental pathology	2022	"Circular RNAs hsa_circ_0001438 and hsa_circ_0000417 are downregulated and upregulated, respectively, in hepatocellular carcinoma."	hsa_circ_0000417		hsa_circ_CPSF6	CPSF6	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000417 was identified from public RNA-seq data as upregulated in primary HCC tissues and was confirmed by RT-qPCR to be elevated in HCC cell lines, especially JHH-5. The study proposes hsa_circ_0000417 as a potential HCC diagnostic biomarker and suggests it may help distinguish differentiation status when combined with hsa_circ_0001438."	0.6193
36155326	"Pathology, research and practice"	2022	Circ_0005050 promotes the proliferation of oral squamous cell carcinoma and inhibits the apoptosis by activating JAK/STAT3 signaling pathway.	hsa_circ_0005050	Circ_0005050 	hsa_circ_XPO1	XPO1	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circ_0005050 is up-regulated in OSCC cell lines and promotes malignant growth by enhancing proliferation and suppressing apoptosis. Mechanistically, it sponges miR-23a-3p and miR-625-5p to increase STAT3 expression and activate the JAK/STAT3 signaling pathway."	0.7624
36162459	Experimental eye research	2022	CircRNA SCMH1 regulates the miR-200a-3p/ZEB1 signaling axis to promote diabetes-induced retinal epithelial-mesenchymal transition.		circSCMH1	hsa_circ_SCMH1	SCMH1	Diabetic retinopathy 	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR	"circSCMH1 is up-regulated in high glucose-stimulated human ARPE-19 retinal pigment epithelial cells and promotes diabetic retinopathy-related cell proliferation, migration, and EMT while inhibiting apoptosis. Mechanistically, circSCMH1 sponges miR-200a-3p to activate ZEB1 expression, and circSCMH1 knockdown alleviates retinal EMT in STZ-induced diabetic mice."	0.6594
36163585	Human cell	2023	CircMERTK modulates the suppressive capacity of tumor-associated macrophage via targeting IL-10 in colorectal cancer.	hsa_circ_0056121	circMERTK 	hsa_circ_MERTK	Mertk	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circMERTK is up-regulated in TAM-like cells and CRC tissues, especially overlapping with CD68-positive macrophages. It promotes TAM-like cell immunosuppressive activity by sponging miR-125a-3p to increase IL-10, thereby enhancing CD8+ T-cell apoptosis, and may represent a potential therapeutic target in CRC."	0.8331
36168302	Neuropathology and applied neurobiology	2023	CircRNA SRRM4 affects glucose metabolism by regulating PKM alternative splicing via SRSF3 deubiquitination in epilepsy.	hsa_circ_0097512	circRNA serine 	hsa_circ_SRRM4 	SRRM4 	epilepsy 	MONDO:0005027	epilepsy	up-regulated	RT-qPCR; ISH; RNA-seq	"circSRRM4 is up-regulated in human TLE lesions and KA-induced epilepsy models. It binds and stabilizes SRSF3 by inhibiting ubiquitin-proteasome degradation, promoting PKM alternative splicing toward PKM2, glycolysis, and epileptogenesis; circSrrm4 silencing reduces seizures and improves hypometabolism and neuronal loss."	0.8416
36168302	Neuropathology and applied neurobiology	2023	CircRNA SRRM4 affects glucose metabolism by regulating PKM alternative splicing via SRSF3 deubiquitination in epilepsy.		circRNA serine 	rno_circ_Srrm4	Srrm4	epilepsy 	MONDO:0005027	epilepsy	up-regulated	RT-qPCR; ISH; RNA-seq	"circSRRM4 is up-regulated in human TLE lesions and KA-induced epilepsy models. It binds and stabilizes SRSF3 by inhibiting ubiquitin-proteasome degradation, promoting PKM alternative splicing toward PKM2, glycolysis, and epileptogenesis; circSrrm4 silencing reduces seizures and improves hypometabolism and neuronal loss."	0.8416
36168302	Neuropathology and applied neurobiology	2023	CircRNA SRRM4 affects glucose metabolism by regulating PKM alternative splicing via SRSF3 deubiquitination in epilepsy.	hsa_circ_0095372	circARNTL	hsa_circ_ARNTL	ARNTL	temporal lobe epilepsy 	MONDO:0005115	temporal lobe epilepsy	up-regulated	RT-qPCR; RNA-seq	circARNTL was selected from RNA-Seq data as an up-regulated candidate circRNA in TLE and was confirmed by RT-qPCR to be significantly elevated in epileptic tissues. No mechanistic or functional experiments were reported for this circRNA.	0.3588
36168302	Neuropathology and applied neurobiology	2023	CircRNA SRRM4 affects glucose metabolism by regulating PKM alternative splicing via SRSF3 deubiquitination in epilepsy.	hsa_circ_0078768	circFAM120B	hsa_circ_FAM120B	FAM120B	temporal lobe epilepsy 	MONDO:0005115	temporal lobe epilepsy	up-regulated	RT-qPCR; RNA-seq	circFAM120B was selected from RNA-Seq data as an up-regulated candidate circRNA in TLE and was confirmed by RT-qPCR to be significantly elevated in epileptic tissues. No mechanistic or functional experiments were reported for this circRNA.	0.3588
36168302	Neuropathology and applied neurobiology	2023	CircRNA SRRM4 affects glucose metabolism by regulating PKM alternative splicing via SRSF3 deubiquitination in epilepsy.	hsa_circ_0018334	circPARG	hsa_circ_PARG	PARG	temporal lobe epilepsy 	MONDO:0005115	temporal lobe epilepsy	up-regulated	RT-qPCR; RNA-seq	circPARG was selected from RNA-Seq data as an up-regulated candidate circRNA in TLE and was confirmed by RT-qPCR to be significantly elevated in epileptic tissues. No mechanistic or functional experiments were reported for this circRNA.	0.3588
36168936	Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology	2022	Circ_0072995 drives cervical cancer development by regulating the miR-29a/WDR5 axis.	hsa_circ_0072995	Circular RNA_0072995 			cervical cancer	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"circ_0072995 is up-regulated in cervical cancer tissues and is associated with histological type and FIGO stage. Functionally, it promotes cervical cancer cell proliferation and invasion, inhibits apoptosis, and supports tumour growth in vivo. Mechanistically, circ_0072995 acts through the miR-29a/WDR5 axis, suggesting potential therapeutic relevance."	0.7369
36169884	Human cell	2023	CircZNF367 suppresses osteogenic differentiation of human bone marrow mesenchymal stromal/stem cells via reducing HuR-mediated mRNA stability of LRP5.	hsa_circ_0008842	circZNF367	hsa_circ_ZNF367	ZNF367	osteoporosis	MONDO:0005298	osteoporosis	up-regulated	RT-qPCR; RNA-seq	"In osteoporosis, hsa_circ_0008842/circZNF367 is upregulated in bone tissues and acts as a suppressor of hBMSC migration, invasion and osteogenic differentiation. Mechanistically, circZNF367 interacts with HuR, reduces HuR-mediated stabilization of LRP5 mRNA, lowers LRP5 and active beta-catenin levels, and inhibits Wnt/beta-catenin signaling. The study suggests circZNF367 as a potential biomarker or therapeutic target for osteoporosis."	0.8446
36181383	"Nephrology (Carlton, Vic.)"	2022	"CircHOMER1 aggravates oxidative stress, inflammation and extracellular matrix deposition in high glucose-induced human mesangial cells."	hsa_circ_0006916		hsa_circ_HOMER1	HOMER1	diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"circHOMER1 is up-regulated in high glucose-induced human mesangial cells and in serum from DN patients. It promotes oxidative stress, inflammation and extracellular matrix accumulation by sponging miR-137 to regulate SOX6, and circHOMER1 knockdown alleviates HG-induced HMC injury."	0.7689
36182153	Journal of environmental sciences (China)	2023	Zn2+ loading as a critical contributor to the circ_0008553-mediated oxidative stress and inflammation in response to PM2.5 exposures.	hsa_circ_0008553	circ_0008553	hsa_circ_GPR89C	GPR89C	PM2.5-induced airway inflammation 	MONDO:0043905	pneumonitis	up-regulated	RT-qPCR	"This study identified circ_0008553 as a PM2.5-responsive circRNA in human bronchial epithelial cells. It was upregulated by Zn2+-loaded model PM2.5 and promoted oxidative stress and inflammatory responses, at least in part through a circRNA/miRNA/mRNA regulatory network involving IL6R-related signaling."	0.421
36184488	Clinical and experimental pharmacology & physiology	2022	CircFNDC3B knockdown restrains the progression of oesophageal squamous cell carcinoma through miR-214-3p/CDC25A axis.	hsa_circ_0006948	CircFNDC3B 	hsa_circ_FNDC3B	FNDC3B	oesophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"CircFNDC3B is up-regulated in ESCC tissues and cell lines, and high expression is associated with shorter overall survival. Functionally, circFNDC3B acts as an oncogenic circRNA that promotes ESCC cell proliferation, migration, invasion and xenograft tumour growth while suppressing apoptosis. Mechanistically, it sponges miR-214-3p to increase CDC25A expression, forming a circFNDC3B/miR-214-3p/CDC25A regulatory axis."	0.7554
36190453	Environmental toxicology	2023	CircRPPH1 promotes the stemness of gastric cancer cells by targeting miR-375/SLC7A11 axis.		circRPPH1	hsa_circ_RPPH1	RPPH1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"This study identifies circRPPH1 as an up-regulated circRNA in gastric cancer cells and GC cell spheres. circRPPH1 promotes GC cell stemness and tumor-initiating ability by sponging miR-375 and increasing SLC7A11 expression, thereby implicating ferroptosis regulation in the circRPPH1/miR-375/SLC7A11 axis."	0.6562
36190650	General thoracic and cardiovascular surgery	2023	Circ_0008726 promotes malignant progression of ESCC cells through miR-206/HOXA13 pathway.	hsa_circ_0008726		hsa_circ_DNAJB6	DNAJB6	Esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circ_0008726 is up-regulated in ESCC tissues and cell lines and is associated with aggressive clinicopathological features and poor survival. Functionally, circ_0008726 promotes ESCC proliferation, invasion, angiogenesis and tumor growth while inhibiting apoptosis. Mechanistically, it acts as a miR-206 sponge to regulate HOXA13 expression through the miR-206/HOXA13 axis."	0.8354
36193777	Molecular carcinogenesis	2022	Transcription factor Nrf2 binds to circRNAPIBF1 to regulate SOD2 in lung adenocarcinoma progression.	hsa_circ_0100832	circPIBF1 	hsa_circ_PIBF1	PIBF1	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circPIBF1 is up-regulated in lung adenocarcinoma and high expression predicts poorer survival and more aggressive clinical features. Functionally, circPIBF1 promotes LUAD cell growth and suppresses pyroptosis by binding Nrf2, enhancing SOD2 transcription, and facilitating EP300-mediated H3K27ac modification of the SOD2 promoter. Knockdown of circPIBF1 inhibits tumor growth in vitro and in xenograft models, supporting its potential as a prognostic biomarker and therapeutic target."	0.8913
36205752	Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]	2023	Knockdown of circ-ADAM9 inhibits malignant phenotype and enhances radiosensitivity in breast cancer cells via acting as a sponge for miR-383-5p.	hsa_circ_0001791	circ-ADAM9 	hsa_circ_ADAM9	ADAM9	breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ-ADAM9 is up-regulated in breast cancer tissues and cells. It promotes malignant phenotypes and radioresistance by sponging miR-383-5p and increasing PFN2 expression; knockdown of circ-ADAM9 suppresses proliferation, migration, invasion and tumor growth while enhancing apoptosis and radiosensitivity."	0.8119
36208372	Biochemical genetics	2023	Hsa_circ_0001535 Regulates Colorectal Cancer Progression via the miR-433-3p/RBPJ Axis.	hsa_circ_0001535	circ_0001535	hsa_circ_FAM13B	FAM13B	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"Hsa_circ_0001535/circ_0001535 is up-regulated in CRC tissues and cell lines. It promotes CRC progression by enhancing proliferation, migration, invasion, angiogenesis and tumor growth while suppressing apoptosis. Mechanistically, circ_0001535 acts as a ceRNA for miR-433-3p to up-regulate RBPJ, suggesting that targeting the circ_0001535/miR-433-3p/RBPJ axis may have therapeutic value in CRC."	0.8006
36214613	Oral diseases	2023	hsa_circ_0000264 promotes tumor progression via the hsa-let-7b-5p/HMGA2 axis in head and neck squamous cell carcinoma.	hsa_circ_0000264	circCHST15	hsa_circ_CHST15	CHST15	head and neck squamous cell carcinoma 	MONDO:0010150	head and neck squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000264/circCHST15 is upregulated in HNSCC tissues and cell lines and is mainly cytoplasmic. It promotes HNSCC cell migration, invasion, EMT, and lung metastasis by sponging hsa-let-7b-5p to increase HMGA2 expression, suggesting a potential therapeutic target in HNSCC."	0.8571
36224454	Journal of endocrinological investigation	2023	Silencing circ_0000644 inhibits papillary thyroid cancer cell malignancy by combining with miR-671-5p to release the inhibition on ANXA2.	hsa_circ_0000644	circ_0000644			papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circ_0000644 is up-regulated in papillary thyroid cancer tissues and cells and is associated with lymph-node metastasis and TNM stage. Functionally, circ_0000644 promotes PTC cell proliferation, angiogenic tube formation, migration, invasion, metastasis-related protein expression, and xenograft tumor growth while suppressing apoptosis. Mechanistically, it acts as a cytoplasmic ceRNA by sponging miR-671-5p to up-regulate ANXA2 via the circ_0000644/miR-671-5p/ANXA2 axis."	0.7373
36244580	Brain research bulletin	2022	Ligustrazine exerts neuroprotective effects via circ_0008146/miR-709/Cx3cr1 axis to inhibit cell apoptosis and inflammation after cerebral ischemia/reperfusion injury.	mmu_circ_0008146	circ_0008146 			cerebral ischemia	MONDO:0002679	cerebral infarction	up-regulated	RT-qPCR; RNA-seq	"circ_0008146 is up-regulated in the MCAO model of cerebral ischemia/reperfusion injury and is decreased by ligustrazine treatment. The study supports a circ_0008146/miR-709/Cx3cr1 ceRNA axis in which circ_0008146 promotes inflammatory cytokine production and neuron cell death, while circ_0008146 silencing suppresses inflammation and apoptosis-like neuron death in LPS-induced BV-2 cells."	0.593
36251122	Molecular biotechnology	2023	CircRNA GRB10 is a Novel Biomarker for the Accurate Diagnosis of Lumbar Degenerative Disc Disease.			hsa_circ_GRB10	GRB10	Lumbar degenerative disc disease 	MONDO:0044339	lumbar disk degenerative disorder	down-regulated	RT-qPCR	"This clinical study found that plasma circRNA GRB10 is specifically downregulated in patients with lumbar degenerative disc disease compared with healthy controls and several symptom-mimicking disorders. RT-qPCR and ROC analysis support plasma GRB10 as a diagnostic biomarker for LDDD, and its increase after treatment may indicate recovery or treatment response."	0.5261
36253542	Cancer gene therapy	2023	MiR-330-5p and miR-1270 target essential components of RNA polymerase I transcription and exhibit a novel tumor suppressor role in lung adenocarcinoma.	hsa_circ_0055467	circ_0055467	hsa_circ_POLR1A	POLR1A	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"In LUAD, POLR1A-derived circ_0055467 is upregulated in tumor tissues and inversely correlated with miR-330-5p. The study supports an oncogenic regulatory role in which circ_0055467 decoys/represses miR-330-5p, thereby contributing to enhanced Pol I transcriptional machinery activity and rRNA synthesis."	0.62
36260529	Environmental toxicology	2023	"N6-methyladenosine modification in trophoblasts promotes circSETD2 expression, inhibits miR-181a-5p, and elevates MCL1 transcription to reduce apoptosis of trophoblasts."		circSETD2	hsa_circ_SETD2	SETD2	preeclampsia 	MONDO:0005081	preeclampsia	down-regulated	RT-qPCR	"circSETD2 is down-regulated in preeclampsia-associated trophoblasts and its overexpression promotes trophoblast proliferation and invasion while inhibiting apoptosis. Mechanistically, m6A modification upregulates circSETD2, which acts as a ceRNA sponge for miR-181a-5p to increase MCL1 transcription and thereby protect trophoblasts from apoptosis."	0.6253
36260529	Environmental toxicology	2023	"N6-methyladenosine modification in trophoblasts promotes circSETD2 expression, inhibits miR-181a-5p, and elevates MCL1 transcription to reduce apoptosis of trophoblasts."			rno_circ_Setd2	Setd2	preeclampsia 	MONDO:0005081	preeclampsia	down-regulated	RT-qPCR	"circSETD2 is down-regulated in preeclampsia-associated trophoblasts and its overexpression promotes trophoblast proliferation and invasion while inhibiting apoptosis. Mechanistically, m6A modification upregulates circSETD2, which acts as a ceRNA sponge for miR-181a-5p to increase MCL1 transcription and thereby protect trophoblasts from apoptosis."	0.6253
36264417	Genes & genomics	2023	High-throughput data on circular RNA reveal novel insights into chronic glomerulonephritis.		rno_circrna_689 	rno_circ_Slc35f5	Slc35f5	chronic glomerulonephritis 	MONDO:0002462	glomerulonephritis	up-regulated	RT-qPCR; RNA-seq	"rno_circrna_689 was up-regulated in renal cortex tissues from Adriamycin-induced CGN rats and validated by qRT-PCR. The study predicted that circRNA-689 may act through a circRNA-miRNA-mRNA ceRNA subnetwork involving cell proliferation, migration, apoptosis, inflammation, fibrosis, and renal function dysregulation."	0.3684
36264417	Genes & genomics	2023	High-throughput data on circular RNA reveal novel insights into chronic glomerulonephritis.		rno_circrna_3217 	rno_circ_Stk4	Stk4	chronic glomerulonephritis 	MONDO:0002462	glomerulonephritis	up-regulated	RT-qPCR; RNA-seq	"rno_circrna_3217 was up-regulated in Adriamycin-induced CGN rat renal cortex and its expression change was confirmed by qRT-PCR. Bioinformatics analysis suggested a circRNA-miRNA-mRNA ceRNA subnetwork connected with cell growth, TGF-beta signaling, mTOR signaling, renal fibrosis, and renal function disorder."	0.3684
36264417	Genes & genomics	2023	High-throughput data on circular RNA reveal novel insights into chronic glomerulonephritis.		rno_circrna_1327 	rno_circ_Gtf2e2	Gtf2e2	chronic glomerulonephritis 	MONDO:0002462	glomerulonephritis	down-regulated	RT-qPCR; RNA-seq	"rno_circrna_1327 was down-regulated in renal cortex tissues from Adriamycin-induced CGN rats and validated by qRT-PCR. The study predicted that circRNA-1327 may act in a ceRNA network involving miR-145-5p and downstream mRNAs, with possible roles in apoptosis, fibrosis, mTOR signaling, and podocyte morphology and function."	0.3684
36264417	Genes & genomics	2023	High-throughput data on circular RNA reveal novel insights into chronic glomerulonephritis.		rno_circrna_5001 	rno_circ_Myo9a	Myo9a	chronic glomerulonephritis 	MONDO:0002462	glomerulonephritis	down-regulated	RT-qPCR; RNA-seq	"rno_circrna_5001 was down-regulated in renal cortex tissues from Adriamycin-induced CGN rats and validated by qRT-PCR. The study predicted that circRNA-5001 may act through a ceRNA network involving miR-145-5p and downstream mRNAs, with possible links to metabolic processes, focal adhesion, and MAPK signaling in glomerular disease."	0.3684
36265525	Toxicology	2022	RNA-Seq approach to investigate the effects of melatonin on bone marrow-derived dendritic cells from dextran sodium sulfate-induced colitis mice.		circRNA-0520			dextran sulfate sodium-induced colitis 	MONDO:0005292	colitis	dysregulated	RNA-seq	"circRNA-0520 was identified by RNA-Seq/bioinformatic ceRNA analysis in BMDCs from DSS-induced colitis mice with or without melatonin treatment. It was predicted to interact with miRNA-709 and to participate in a ceRNA network involving Ywhaz and Ccl9/Ccl19, potentially regulating BMDC maturation and immune responses through the PI3K-Akt pathway."	0.31
36265525	Toxicology	2022	RNA-Seq approach to investigate the effects of melatonin on bone marrow-derived dendritic cells from dextran sodium sulfate-induced colitis mice.		circRNA-2243			dextran sulfate sodium-induced colitis 	MONDO:0005292	colitis	dysregulated	RNA-seq	"circRNA-2243 was identified by RNA-Seq/bioinformatic ceRNA analysis in BMDCs from DSS-induced colitis mice with or without melatonin treatment. It was predicted to interact with miRNA-709 and to participate in a ceRNA network involving Ywhaz and Ccl9/Ccl19, potentially regulating BMDC maturation and immune responses through the PI3K-Akt pathway."	0.31
36265525	Toxicology	2022	RNA-Seq approach to investigate the effects of melatonin on bone marrow-derived dendritic cells from dextran sodium sulfate-induced colitis mice.		circRNA-0348			dextran sulfate sodium-induced colitis 	MONDO:0005292	colitis	dysregulated	RNA-seq	circRNA-0348 was identified by RNA-Seq/bioinformatic network analysis as one of the important circRNAs in predicted circRNA-miRNA and circRNA-miRNA-mRNA networks in BMDCs from DSS-induced colitis mice with or without melatonin treatment. The article did not specify its individual miRNA or mRNA partners in the text.	0.31
36268878	Head & neck	2023	Knockdown of circGOLPH3 inhibits cell progression and glycolysis by targeting miR-145-5p/lysine demethylase 2A (KDM2A) axis in oral squamous cell carcinoma.			hsa_circ_GOLPH3	GOLPH3	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circGOLPH3 is upregulated in OSCC tissues and cell lines and is associated with higher tumor stage. Functionally, circGOLPH3 acts as a pro-oncogenic circRNA that promotes OSCC proliferation, migration, invasion, EMT, glycolysis and tumor growth while suppressing apoptosis. Mechanistically, cytoplasmic circGOLPH3 sponges miR-145-5p to increase KDM2A expression through a ceRNA mechanism."	0.8174
36300546	Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology	2023	Exosomal hsa_circRNA_047733 integrated with clinical features for preoperative prediction of lymph node metastasis risk in oral squamous cell carcinoma.		hsa_circRNA_047733 			oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	"Plasma exosomal hsa_circRNA_047733 was significantly downregulated in OSCC patients with positive lymph node metastasis, while higher expression was associated with lower LNM risk. The study supports hsa_circRNA_047733 as a preoperative biomarker and nomogram component for predicting regional lymph node status, with a predicted circRNA-miRNA-mRNA network involving hsa-miR-4464, hsa-miR-4748 and hub genes."	0.6556
36301458	Metabolic brain disease	2022	Hsa_circ_0043949 reinforces temozolomide resistance via upregulating oncogene ITGA1 axis in glioblastoma.	hsa_circ_0043949	circ_0043949	hsa_circ_BRCA1	BRCA1	glioblastoma 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR	"Hsa_circ_0043949/circ_0043949 is upregulated in TMZ-resistant GBM tissues, cells, and exosomes. It promotes temozolomide resistance by acting as a miR-876-3p sponge to increase ITGA1 expression, thereby enhancing proliferation, invasion, migration, and reducing apoptosis. Exosomal circ_0043949 derived from TMZ-resistant GBM cells reinforces TMZ resistance in xenograft models and may represent a therapeutic target for sensitizing GBM to TMZ."	0.8006
36315981	"American journal of reproductive immunology (New York, N.Y. : 1989)"	2022	Circ_0031027 adjusts the advancement of cervical cancer by miR-587/SOCS5 axis.	hsa_circ_0031027	Circ_0031027	hsa_circ_TMCO3	TMCO3	cervical cancer 	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR	"Circ_0031027 is downregulated in cervical cancer tissues and cell lines. Its overexpression suppresses cervical cancer cell proliferation, migration, invasion, and xenograft tumor growth, at least partly through the miR-587/SOCS5 regulatory axis."	0.8001
36316592	Biochemical genetics	2023	Circ_0008529 Contributes to Renal Tubular Cell Dysfunction in High Glucose Stress via miR-185-5p/SMAD2 Pathway in Diabetic Nephropathy.	hsa_circ_0008529	circ_0008529	hsa_circ_ACTR2	ACTR2	diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"circ_0008529 is upregulated in high glucose-stressed HK-2 renal tubular cells and in urinary exosomes from DN patients. It promotes renal tubular cell dysfunction by acting as a ceRNA for miR-185-5p to regulate SMAD2, thereby enhancing apoptosis, inflammation and ECM accumulation while inhibiting cell viability and cell cycle progression. Urinary exosomal circ_0008529 also showed potential diagnostic value for diabetic nephropathy."	0.8568
36322706	Current eye research	2023	Ectopic circSTK39 Expression Ameliorates Hydrogen Peroxide-Induced Human Lens Epithelial Cell Apoptosis and Oxidative Stress through the miR-125a-5p/ERCC6 Pathway.		circSTK39 	hsa_circ_STK39	STK39	age-related cataract 	MONDO:0004847	senile cataract	down-regulated	RT-qPCR	"circSTK39 is downregulated in ARC lens tissues and H2O2-induced SRA01/04 cells. Its overexpression protects human lens epithelial cells from H2O2-induced injury by promoting proliferation and inhibiting apoptosis and oxidative stress, acting through a circSTK39/miR-125a-5p/ERCC6 ceRNA axis."	0.7507
36323918	Human cell	2023	Exosomal circ_0091741 promotes gastric cancer cell autophagy and chemoresistance via the miR-330-3p/TRIM14/Dvl2/Wnt/beta-catenin axis.	hsa_circ_0091741	circ_0091741			gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circ_0091741 is up-regulated in gastric cancer cells, oxaliplatin-resistant HGC-27/OXA cells, and gastric cancer cell-derived exosomes. Exosomal circ_0091741 promotes autophagy, oxaliplatin resistance, cell viability, and xenograft tumorigenesis by sponging miR-330-3p, increasing TRIM14, stabilizing Dvl2, and activating Wnt/beta-catenin signaling. Silencing exosomal circ_0091741 suppresses these malignant and chemoresistant phenotypes."	0.7294
36326978	Metabolic brain disease	2023	Propofol inhibits glioma progression by regulating circMAPK4/miR-622/HOXA9 axis.	hsa_circ_0047688	circMAPK4 	hsa_circ_MAPK4		glioma	MONDO:0021042	glioma	unknown	RT-qPCR	"This study shows that propofol decreases circMAPK4 expression in human glioma U251 and LN229 cells. circMAPK4 acts as an oncogenic ceRNA that sponges miR-622 to regulate HOXA9, thereby promoting proliferation, migration and invasion while suppressing apoptosis. Knockdown of circMAPK4 mediates anti-glioma effects, whereas circMAPK4 overexpression attenuates propofol-induced inhibition of glioma progression."	0.6578
36327671	Reproductive biology	2022	Circ_0015756 promotes ovarian cancer progression via the miR-145-5p/PSAT1 axis.	hsa_circ_0015756	circ_0015756	hsa_circ_CFH	CFH	ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circ_0015756 is up-regulated in ovarian cancer tissues and cell lines and acts as an oncogenic circRNA. Its knockdown suppresses proliferation, migration, invasion and in vivo tumor growth while inducing apoptosis. Mechanistically, circ_0015756 sponges miR-145-5p to increase PSAT1 expression, forming a circ_0015756/miR-145-5p/PSAT1 regulatory axis."	0.713
36357650	Journal of cell communication and signaling	2023	CircRNA hsa_circ_0001627 aggravates cervical cancer progression through upregulation of FNDC3B and activating PI3K/mTOR signaling pathway.	hsa_circ_0001627				cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001627 is up-regulated in cervical cancer tissues and cell lines, and high expression predicts poor overall survival. Functionally, it promotes CC cell proliferation, migration, invasion, tumor growth and metastatic activity. Mechanistically, hsa_circ_0001627 sponges miR-1225-5p to increase FNDC3B expression and activate the PI3K/mTOR pathway, suggesting potential diagnostic, prognostic and therapeutic relevance."	0.798
36369900	"American journal of reproductive immunology (New York, N.Y. : 1989)"	2023	Circ_0000471 suppresses the progression of ovarian cancer through mediating mir-135b-5p/dusp5 axis.	hsa_circ_0000471		hsa_circ_N4BP2L2	N4BP2L2	ovarian cancer 	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR	"Circ_0000471 is down-regulated in ovarian cancer tissues and cell lines and acts as a tumor suppressor. Its overexpression inhibits proliferation, migration, invasion, motility, and xenograft tumor growth while promoting apoptosis, mainly through sponging miR-135b-5p to increase DUSP5 expression. The study also suggests potential diagnostic value for circ_0000471 expression in OC patients."	0.8769
36376550	Molecular biotechnology	2023	"CircTFF1 Promotes Proliferation, Migration and Invasion of Lung Cancer Cells by Facilitating Methylation of BCL6B Promoter via miR-29c-3p/DNMT3A Axis."	hsa_circ_0061825		hsa_circ_TFF1		lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circTFF1 is upregulated in lung cancer cell lines and promotes malignant phenotypes including proliferation, migration and invasion. Mechanistically, circTFF1 sponges miR-29c-3p to increase DNMT3A expression, thereby facilitating BCL6B promoter methylation and suppressing the tumor-suppressive role of BCL6B."	0.7027
36380035	Biochemical genetics	2023	Circ_MBNL3 Restrains Hepatocellular Carcinoma Progression by Sponging miR-873-5p to Release PHF2.		Circ_MBNL3 	hsa_circ_MBNL3	MBNL3	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"Circ_MBNL3 is down-regulated in HCC tissues and cell lines and acts as a tumor suppressor. It is mainly cytoplasmic and restrains HCC cell proliferation, migration, invasion and xenograft tumor growth while promoting apoptosis. Mechanistically, circ_MBNL3 sponges miR-873-5p to up-regulate/release PHF2 through a circ_MBNL3/miR-873-5p/PHF2 ceRNA axis."	0.8175
36394649	Cellular and molecular life sciences : CMLS	2022	"A circular RNA, circPTPN14, increases MYC transcription by interacting with FUBP1 and exacerbates renal fibrosis."	hsa_circ_0007015	circPTPN14	hsa_circ_PTPN14	PTPN14	renal fibrosis 	MONDO:0000494	renal fibrosis	up-regulated	RT-qPCR; ISH; RNA-seq	"circPTPN14 is a conserved PTPN14-derived circRNA up-regulated in renal fibrosis in human kidneys, mouse IR/UUO models, and TGFbeta1-stimulated TECs. It promotes profibrotic gene expression and renal fibrosis by binding FUBP1, enhancing FUBP1-FUSE interaction, and increasing MYC transcription. Its expression correlates with fibrosis degree and MYC levels in patient kidney samples, suggesting diagnostic or therapeutic potential in CKD-associated renal fibrosis."	0.8861
36394649	Cellular and molecular life sciences : CMLS	2022	"A circular RNA, circPTPN14, increases MYC transcription by interacting with FUBP1 and exacerbates renal fibrosis."	mmu_circ_0000130	circPTPN14	mmu_circ_PTPN14	PTPN14	renal fibrosis 	MONDO:0000494	renal fibrosis	up-regulated	RT-qPCR; ISH; RNA-seq	"circPTPN14 is a conserved PTPN14-derived circRNA up-regulated in renal fibrosis in human kidneys, mouse IR/UUO models, and TGFbeta1-stimulated TECs. It promotes profibrotic gene expression and renal fibrosis by binding FUBP1, enhancing FUBP1-FUSE interaction, and increasing MYC transcription. Its expression correlates with fibrosis degree and MYC levels in patient kidney samples, suggesting diagnostic or therapeutic potential in CKD-associated renal fibrosis."	0.8861
36399942	Environment international	2022	DNMT3A-mediated high expression of circ_0057504 promotes benzo[a]pyrene-induced DNA damage via the NONO-SFPQ complex in human bronchial epithelial cells.	hsa_circ_0057504	hsa_-circ_0057504	hsa_circ_TMEM194B	TMEM194B	B[a]P-induced DNA damage 	MONDO:0005070	neoplasm	up-regulated	RT-qPCR; ISH; Microarray	"circ_0057504 is up-regulated after B[a]P exposure in human bronchial epithelial cells and in B[a]P-treated mouse lung tissue. Its expression is induced through DNMT3A-mediated hypomethylation of the TMEM194B locus, and it promotes B[a]P-induced DNA double-strand damage by binding NONO and SFPQ and suppressing NONO-SFPQ complex formation."	0.8491
36399942	Environment international	2022	DNMT3A-mediated high expression of circ_0057504 promotes benzo[a]pyrene-induced DNA damage via the NONO-SFPQ complex in human bronchial epithelial cells.	mmu_circ_0057504	mmu-circ_0057504	mmu-circ_0057504	TMEM194B	B[a]P-induced DNA damage 	MONDO:0005070	neoplasm	up-regulated	RT-qPCR; ISH; Microarray	"circ_0057504 is up-regulated after B[a]P exposure in human bronchial epithelial cells and in B[a]P-treated mouse lung tissue. Its expression is induced through DNMT3A-mediated hypomethylation of the TMEM194B locus, and it promotes B[a]P-induced DNA double-strand damage by binding NONO and SFPQ and suppressing NONO-SFPQ complex formation."	0.8491
37475081	Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica	2023	[Intervention effect of Chuanxiong-Chishao herb pair on circRNA/lncRNA expression profile in a myocardial infarction-atherosclerosis model].		circRNA_07227	mmu_circ_Tnxb	Tnxb	coronary heart disease 	MONDO:0005010	coronary artery disorder	up-regulated	RNA-seq	"circRNA_07227 was up-regulated in the aorta of the MI-AS atherosclerosis model and down-regulated after CX-CS treatment. The study links its disease-associated change to the broader CX-CS-regulated circRNA expression profile related to lipid metabolism, inflammation, angiogenesis, and other atherosclerosis-relevant processes."	0.3963
37475081	Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica	2023	[Intervention effect of Chuanxiong-Chishao herb pair on circRNA/lncRNA expression profile in a myocardial infarction-atherosclerosis model].		circRNA_11464			coronary heart disease 	MONDO:0005010	coronary artery disorder	up-regulated	RNA-seq	circRNA_11464 was up-regulated in atherosclerotic aorta from the MI-AS model and was reversed by CX-CS treatment. No host gene or specific downstream interaction was reported.	0.3963
37475081	Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica	2023	[Intervention effect of Chuanxiong-Chishao herb pair on circRNA/lncRNA expression profile in a myocardial infarction-atherosclerosis model].		circRNA_10354	mmu_circ_Snhg11	Snhg11	coronary heart disease 	MONDO:0005010	coronary artery disorder	down-regulated	RNA-seq	"circRNA_10354 was down-regulated in atherosclerotic aorta from the MI-AS model and up-regulated after CX-CS treatment. Its host gene was reported as Snhg11, but no direct molecular interaction or mechanistic validation was performed."	0.3963
37475081	Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica	2023	[Intervention effect of Chuanxiong-Chishao herb pair on circRNA/lncRNA expression profile in a myocardial infarction-atherosclerosis model].		circRNA_16490	mmu_circ_Sik2	Sik2	coronary heart disease 	MONDO:0005010	coronary artery disorder	down-regulated	RNA-seq	circRNA_16490 was down-regulated in atherosclerotic aorta from the MI-AS model and up-regulated after CX-CS treatment. The paper reports its host gene as Sik2 and links the overall aortic circRNA profile to lipid metabolism and other AS-related processes.	0.3963
37475081	Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica	2023	[Intervention effect of Chuanxiong-Chishao herb pair on circRNA/lncRNA expression profile in a myocardial infarction-atherosclerosis model].		circRNA_11505	mmu_circ_Aco1	Aco1	coronary heart disease 	MONDO:0005010	coronary artery disorder	down-regulated	RNA-seq	"circRNA_11505 was down-regulated in ischemic myocardium of the MI-AS model and up-regulated after CX-CS treatment. The article suggests it may be related to energy metabolism, while cardiac circRNA enrichment analyses point to angiogenesis, HIF-1, VEGF, MAPK, and autophagy-related mechanisms."	0.31
37477517	Pathology international	2023	Circ_0001955 promotes non-small cell lung cancer cell proliferation and invasion by regulating MiR-29a-3p/NKIRAS2 axis to activate the nuclear factor-kappaB pathway.	hsa_circ_0001955	circ_0001955			non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0001955 is upregulated in NSCLC cells and promotes NSCLC cell proliferation, invasion, and xenograft tumor growth. Mechanistically, circ_0001955 mainly localizes to the cytoplasm and acts as a miR-29a-3p sponge to increase NKIRAS2 expression, thereby activating the NF-kappaB pathway; STAT4 was also reported to transcriptionally induce circ_0001955 upregulation."	0.7123
37483096	Environmental toxicology	2023	Circ_0040994 depletion alleviates lipopolysaccharide-induced HK2 cell injury through miR-17-5p/TRPM7 axis.	hsa_circ_0040994	circ_0040994			sepsis 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR	"circ_0040994 is upregulated in serum from septic AKI patients and in LPS-treated HK2 cells. Its knockdown alleviates LPS-induced HK2 cell injury by increasing viability and reducing apoptosis, inflammatory cytokine production, and oxidative stress. Mechanistically, circ_0040994 sponges miR-17-5p to regulate TRPM7."	0.7936
37485755	Journal of biochemical and molecular toxicology	2023	Circ_PRDM5/miR-25-3p/ANKRD46 axis is associated with cell malignant behaviors in subjects with breast cancer evaluated by ultrasound.	hsa_circ_0005654	CircRNA PR 	hsa_circ_PRDM5	PRDM5	breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	"Circ_PRDM5 is downregulated in breast cancer tissues and cells. Functionally, its overexpression suppresses BC cell viability, proliferation, migration, invasion and xenograft tumor growth, while promoting apoptosis. Mechanistically, circ_PRDM5 acts as a sponge for miR-25-3p to increase ANKRD46 expression, forming a circ_PRDM5/miR-25-3p/ANKRD46 regulatory axis."	0.786
37485985	Oral diseases	2024	Targeting Circ-OCAC suppress oral squamous cell carcinoma progression.		circ_010873 	hsa_circ_PCMTD1	PCMTD1	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR; RNA-seq	"circ-OCAC is a PCMTD1-derived circRNA that is significantly downregulated in OSCC tissues and cell lines. It functions as a tumor suppressor by binding miR-411-5p, regulating DUSP1, and inhibiting PI3K/Akt signaling, thereby suppressing proliferation, migration, invasion, tumor growth and metastasis. Its expression is associated with tumor stage and moderate diagnostic performance, and pH-responsive nanoparticle-mediated circ-OCAC delivery enhanced antitumor effects in xenograft models."	0.8913
37493101	Molecular carcinogenesis	2023	circSLC25A13 acts as a ceRNA to regulate AML progression via miR-616-3p/ADCY2 axis.	hsa_circ_0081188	circSLC25A13	hsa_circ_SLC25A13	SLC25A13	acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; RNA-seq	"circSLC25A13 is an oncogenic circRNA in AML whose high expression is associated with poor patient survival. It promotes AML cell proliferation and survival, inhibits apoptosis, reduces Ara-C sensitivity, and accelerates AML progression in vivo through a ceRNA mechanism involving miR-616-3p and ADCY2."	0.8611
37493583	"Shock (Augusta, Ga.)"	2023	KNOCKDOWN OF CIRC_0001379 ATTENUATES HYPOXIA/REOXYGENATION-INDUCED CARDIOMYOCYTE APOPTOSIS AND INFLAMMATORY RESPONSE BY MIR-98-5P/SOX6 AXIS.	mmu_circ_0001379	circ_0001379	mmu_circ_Zfp644	Zfp644	Acute myocardial infarction 	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR	"circ_0001379 is up-regulated in AMI mouse cardiac tissue and H/R-induced HL-1 cardiomyocytes. Its knockdown attenuates cardiomyocyte apoptosis and inflammatory cytokine release while improving cell viability/proliferation, mainly through a cytoplasmic ceRNA mechanism involving miR-98-5p and SOX6."	0.7827
37494801	"Pathology, research and practice"	2023	Circ_0087862 promotes tumorigenesis and glycolysis in colorectal cancer by sponging miR-296-3p to regulate PGK1 expression.	hsa_circ_0087862	circ_0087862	hsa_circ_RAD23B	RAD23B	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0087862 is up-regulated in colorectal cancer tissues and cells and functions as an oncogenic circRNA. It promotes CRC proliferation, invasion, glycolysis and in vivo tumor growth while suppressing apoptosis, mainly through sponging miR-296-3p to up-regulate PGK1. The study suggests circ_0087862 may be an exploitable therapeutic target for CRC."	0.8571
37495546	Chemical biology & drug design	2023	Sinomenine regulates circTRPM7-related pathway to inhibit gastric cancer cell growth and metastasis.	hsa_circ_0004951	circTRPM7 	hsa_circ_TRPM7	TRPM7	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"This study shows that Sinomenine reduces circTRPM7 expression in gastric cancer cells. CircTRPM7 counteracts Sinomenine's antitumor effects by promoting cell growth, proliferation, migration, invasion and metastasis while suppressing apoptosis, mainly through the circTRPM7/miR-145-5p/PBX3 regulatory axis."	0.6966
37498061	Neoplasma	2023	Circular RNA_0000326 accelerates breast cancer development via modulation of the miR-9-3p/YAP1 axis.	hsa_circ_0000326	Circular RNA_0000326 			breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circ_0000326 is up-regulated in breast cancer tissues and cell lines and high expression predicts poor overall survival. Functionally, circ_0000326 promotes BC cell viability, invasion, stemness and xenograft tumor growth while inhibiting apoptosis. Mechanistically, it sponges miR-9-3p to relieve repression of YAP1, forming a circ_0000326-miR-9-3p-YAP1 regulatory axis."	0.8349
37500967	Biochemical genetics	2024	Downregulation of circ_0035292 Alleviates LPS-Induced WI-38 Cell Injury via Targeting miR-494-3p/TLR4 Pathway in Infantile Pneumonia.	hsa_circ_0035292	circ_0035292 	hsa_circ_TMOD3	TMOD3	infantile pneumonia	MONDO:0005249	pneumonia	up-regulated	RT-qPCR	"circ_0035292/circTMOD3 is up-regulated in serum from infantile pneumonia patients and in LPS-induced WI-38 cells. Functionally, circ_0035292 knockdown protects WI-38 cells from LPS-induced injury by promoting proliferation and reducing apoptosis, inflammation and oxidative stress. Mechanistically, circ_0035292 acts through the miR-494-3p/TLR4 axis and may represent a therapeutic target for infantile pneumonia."	0.7795
37506860	Cellular signalling	2023	Hsa_circ_0000073 promotes lipid synthesis of osteosarcoma through hsa-miR-1184/ FADS2 pathway.	hsa_circ_0000073	hsa_-circ_0000073 			osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"hsa_circ_0000073 is up-regulated in osteosarcoma tissues and high expression is associated with poor survival and aggressive clinicopathological features. Functionally, it promotes lipid synthesis in osteosarcoma cells and xenografts through a ceRNA mechanism involving miR-1184 and FADS2."	0.7967
37507642	Biochemical genetics	2024	circSNTB2 and CUL4A Induces Dysfunction of Nucleus Pulposus Cells by Competitively Binding miR-665.	hsa_circ_0040039	circSNTB2 	hsa_circ_SNTB2	SNTB2	lumbar disc herniation 	MONDO:0044339	lumbar disk degenerative disorder	up-regulated	RT-qPCR; Microarray	"circSNTB2 is up-regulated in NP tissues from LDH patients and in TNF-alpha-treated NP cells. It promotes LDH-related NP cell dysfunction by acting through the miR-665/CUL4A axis, inhibiting NP cell proliferation and promoting apoptosis, while circSNTB2 knockdown alleviates LDH progression in a rat model."	0.7053
37515578	Brain injury	2023	CircRIMS promotes cerebral ischemia-reperfusion injury through increasing apoptosis and targeting the miR-96-5p/JAK/STAT1 axis.		CircRIMS 	mmu_circ_RIMS		cerebral ischemia	MONDO:0002679	cerebral infarction	up-regulated	RT-qPCR; Microarray	"This study reports that mouse circRIMS is up-regulated in MCAO and OGD/RX cerebral ischemia-reperfusion injury models. Functionally, circRIMS promotes CIR injury by enhancing apoptosis, inflammatory cytokine secretion, LDH release, and reduced cell viability. Mechanistically, circRIMS targets miR-96-5p and regulates the miR-96-5p/JAK/STAT1 axis."	0.7446
37515673	Molecular and cellular biochemistry	2024	"Circ_0090231 knockdown protects vascular smooth muscle cells from ox-LDL-induced proliferation, migration and invasion via miR-942-5p/PPM1B axis during atherosclerosis."	hsa_circ_0090231	circ_0090231	hsa_circ_USP9X	USP9X	Atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"circ_0090231 is up-regulated in serum from AS patients and in ox-LDL-treated human aortic VSMCs. It promotes ox-LDL-induced VSMC proliferation, migration and invasion by sponging miR-942-5p and increasing PPM1B expression, suggesting the circ_0090231/miR-942-5p/PPM1B axis as a potential therapeutic target in atherosclerosis."	0.7785
37519165	Journal of integrative neuroscience	2023	Bioinformatics and Experimental Identification of circ_0001535 Associated with Diagnosis and Development of Alzheimer's Disease.	hsa_circ_0001535	circ_0001535			Alzheimer's disease 	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR; RNA-seq	"circ_0001535 is up-regulated in AD and showed the strongest diagnostic performance among the analyzed circRNAs. Mechanistically, it interacts with/regulates E2F1, which binds the DHFR promoter, thereby affecting DHFR expression and promoting apoptosis while inhibiting proliferation/viability in Abeta-induced SH-SY5Y AD model cells."	0.7647
37522575	Journal of biochemical and molecular toxicology	2023	Circ-DTL sponges miR-758-3p to accelerate cervical cancer malignant progression by regulating DCUN1D1 expression.	hsa_circ_0000179	circ-DTL 	hsa_circ_DTL	DTL	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"Circ-DTL is upregulated in cervical cancer tissues and cells and functions as an oncogenic circRNA. Mechanistically, it sponges miR-758-3p to regulate DCUN1D1 expression, promoting proliferation, migration, invasion and xenograft tumor growth while suppressing apoptosis and cell cycle arrest. Its expression is clinically associated with lymph node metastasis and TNM status in cervical cancer patients."	0.844
37522976	Molecular and cellular biochemistry	2024	Hsa_circ_0071589 aggravates stemness and oxaliplatin resistance in colorectal cancer through sponging miR-133b to upregulate SOX13 expression.	hsa_circ_0071589				colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"Hsa_circ_0071589 is upregulated in colorectal cancer tissues and cells and is further elevated in oxaliplatin-resistant CRC cells. It promotes CRC stemness, tumor growth, metastasis-related phenotypes and oxaliplatin resistance by sponging miR-133b and indirectly increasing SOX13 expression, making it a potential therapeutic target for OXP-resistant CRC."	0.8005
37526815	Journal of bioenergetics and biomembranes	2023	Circ_0001714 knockdown alleviates lipopolysaccharide-induced apoptosis and inflammation in renal tubular epithelial cells via miR-129-5p/TRAF6 axis in septic acute kidney injury.	hsa_circ_0001714		hsa_circ_BAZ1B		sepsis-induced AKI 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR	Circ_0001714 is up-regulated in sepsis-AKI patient serum and LPS-stimulated HK-2 cells. It aggravates LPS-induced renal tubular epithelial cell injury by promoting apoptosis and inflammation and inhibiting proliferation through a circ_0001714/miR-129-5p/TRAF6 ceRNA axis. Knockdown of circ_0001714 has a protective effect against LPS-induced HK-2 cell damage.	0.7416
37527157	Molecular cancer research : MCR	2023	Exon Junction Complex Mediates the Cap-Independent Translation of Circular RNA.		circSDHAF2 	hsa_circ_SDHAF2	SDHAF2	colorectal cancer	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"circSDHAF2 is an up-regulated coding circRNA in colorectal cancer tumor tissues. It undergoes EJC-mediated cap-independent translation to produce SDHAF2mh5, and its coding activity promotes tumorsphere formation and xenograft tumor growth. Knockdown of circSDHAF2 suppresses anchorage-independent growth and delays tumor formation in mice."	0.8191
37531026	Molecular neurobiology	2023	Exosomal circCNOT6L Regulates Astrocyte Apoptotic Signals Induced by Hypoxia Exposure Through miR99a-5p/SERPINE1 and Alleviates Ischemic Stroke Injury.	hsa_circ_0006168	circCNOT6L	hsa_circ_CNOT6L	CNOT6L	ischemic stroke 	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR	"CircCNOT6L/hsa_circ_0006168 is down-regulated in plasma and plasma exosomes from ischemic stroke patients and in OGD/R-exposed A172 astrocyte-like cells. The study supports a protective role in which circCNOT6L sponges hsa-miR-99a-5p to maintain SERPINE1 expression, thereby attenuating astrocyte apoptotic signaling and associating with lower IS severity."	0.8537
37532090	Genomics	2023	Hsa_circ_0003098 promotes bladder cancer progression via miR-377-5p/ACAT2 axis.	hsa_circ_0003098		hsa_circ_BANP	BANP	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0003098 is upregulated in bladder cancer tissues and cell lines, and high expression is associated with poor prognosis and aggressive clinicopathological features. It promotes proliferation, migration, invasion, tumor growth, and cholesteryl ester accumulation by sponging miR-377-5p and upregulating ACAT2. The study supports hsa_circ_0003098 as an oncogenic circRNA and a potential prognostic biomarker and therapeutic target for bladder cancer."	0.8931
37533154	Human & experimental toxicology	2023	Circular RNA 0000157 depletion protects human bronchial epithelioid cells from cigarette smoke extract-induced human bronchial epithelioid cell injury through the microRNA-149-5p/bromodomain containing 4 pathway.	hsa_circ_0000157		hsa_circ_SELL		smoke-related chronic obstructive pulmonary disease 	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR	"circ_0000157 is upregulated in the blood of smokers with COPD and in CSE-induced 16HBE cells. Its depletion protects bronchial epithelioid cells from CSE-induced injury by promoting proliferation and reducing apoptosis, inflammatory cytokine production, and oxidative stress. Mechanistically, circ_0000157 functions as a miR-149-5p sponge to regulate BRD4 expression through the circ_0000157/miR-149-5p/BRD4 axis."	0.7977
37536029	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2023	Uncovering the expression of circPVT1 in the extracellular vesicles of acute myeloid leukemia patients.	hsa_circ_0001821	circPVT1	hsa_circ_PVT1	PVT1	acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	dysregulated	RT-qPCR	"This study found circPVT1 overexpression in primary AML blast cells compared with normal CD34+ cells and enrichment of circPVT1 cargo inside plasma EVs from AML patients. The authors propose that EV-associated circPVT1 may participate in communication between leukemic blasts and the tumor microenvironment, although detailed functional mechanisms were not experimentally defined."	0.3588
37540462	Journal of applied genetics	2023	Circular RNA circ_0000119 promotes cervical cancer cell growth and migration via miR-433-3p/PAK2 axis.	hsa_circ_0000119	circ_0000119	hsa_circ_MAN1A2	MAN1A2	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ_0000119 is up-regulated in cervical cancer tissues and cell lines, and high expression is associated with poorer overall survival. Functionally, circ_0000119 promotes CC cell proliferation, cell cycle progression, migration, invasion, and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ_0000119 sponges miR-433-3p to regulate PAK2 expression via the circ_0000119/miR-433-3p/PAK2 axis."	0.8767
37541979	Journal of bioenergetics and biomembranes	2023	Circ_0001806 relieves LPS-induced HK2 cell injury by regulating the expression of miR-942-5p and TXNIP.	hsa_circ_0001806	circ_0001806 	hsa_circ_CSPP1	CSPP1	sepsis 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR	"Circ_0001806 is up-regulated in serum from septic AKI patients and in LPS-treated HK2 cells. It promotes LPS-induced HK2 cell injury by sponging miR-942-5p and increasing TXNIP expression, while knockdown of circ_0001806 alleviates apoptosis, inflammation and oxidative stress and improves cell viability. The study also reports that exosomal circ_0001806 is up-regulated in LPS-induced HK2 cells and may contribute to circ_0001806 delivery."	0.8115
37542851	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2023	CDR1as promotes arrhythmias in myocardial infarction via targeting the NAMPT-NAD+ pathway.		CDR1as 			myocardial infarction 	MONDO:0005068	myocardial infarction	up-regulated	RT-qPCR	"CDR1as is up-regulated in mouse myocardium after MI and in hypoxia-treated cardiomyocytes. The study shows that CDR1as promotes post-infarct ventricular arrhythmias by directly targeting NAMPT protein, reducing NAD+ levels, impairing mitochondrial function, and worsening NaV1.5 and Kir6.2 channel dysregulation. Knockdown of CDR1as improves conduction and repolarization abnormalities and reduces arrhythmia susceptibility."	0.593
37543219	Gene	2023	CircCDK1 blocking IGF2BP2-mediated m6A modification of CPPED1 promotes laryngeal squamous cell carcinoma metastasis via the PI3K/AKT signal pathway.	hsa_circ_0005774	circCDK1	hsa_circ_CDK1	CDK1	laryngeal squamous cell carcinoma 	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circCDK1 is up-regulated in LSCC tissues and cell lines and is associated with poor patient prognosis. EIF4A3 promotes its biogenesis, and circCDK1 binds IGF2BP2 to block IGF2BP2-mediated m6A modification of CPPED1, reducing CPPED1 stability and activating PI3K/AKT signaling. Functionally, circCDK1 promotes LSCC proliferation, migration, invasion and metastasis, suggesting diagnostic, prognostic and therapeutic potential."	0.8809
37543296	Brain research bulletin	2023	Curcumin neuroprotective effects in Parkinson disease during pregnancy.	mmu_circ_0001518	circRNA 0001518			Parkinson disease 	MONDO:0005180	Parkinson disease	up-regulated	RT-qPCR	"In this rotenone-induced Parkinson disease mouse study, circRNA 0001518 was significantly up-regulated in the cerebral tissue of female PD mice, but no significant fetal cerebral tissue difference was observed. Curcumin treatment tended to reduce circRNA 0001518 expression and was linked to neuroprotective effects involving reduced neuronal apoptosis and necrosis."	0.2586
37544863	Injury	2023	Exosomes from ADSCs ameliorate nerve damage in the hippocampus caused by post traumatic brain injury via the delivery of circ-Scmh1 promoting microglial M2 polarization.	mmu_circ_0001253	circ-Scmh1 	mmu_circ_Scmh1	Scmh1	Traumatic brain injury 	MONDO:0858950	traumatic brain injury	down-regulated	RT-qPCR; RNA-seq	"This study identifies mouse exosomal circ-Scmh1 as a protective circRNA in traumatic brain injury. circ-Scmh1 is decreased in TBI mouse serum, enriched in hypoxia-pretreated ADSC exosomes, and improves hippocampal nerve injury by regulating the miR-154-5p/STAT6 axis to promote microglial M2 polarization and suppress inflammation and neuronal apoptosis."	0.6722
37545326	Journal of biochemical and molecular toxicology	2023	"Circ_0006324 regulates cell proliferation, cell-cycle progression, apoptosis, and glycolysis of non-small cell lung cancer cells through miR-496/TRIM59 axis."	hsa_circ_0006324	circ_0006324 	hsa_circ_DENND1B	DENND1B	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"Circ_0006324 is upregulated in NSCLC tissues and cells and is associated with advanced TNM stage and distant metastasis. Functionally, it promotes NSCLC cell proliferation, cell-cycle progression, glycolysis and in vivo tumor growth while suppressing apoptosis. Mechanistically, circ_0006324 acts through the miR-496/TRIM59 axis, functioning as a miR-496 sponge to increase TRIM59 expression."	0.8324
37548713	"Shock (Augusta, Ga.)"	2023	CIRCTDRD9 CONTRIBUTES TO SEPSIS-INDUCED ACUTE LUNG INJURY BY ENHANCING THE EXPRESSION OF RAB10 VIA DIRECTLY BINDING TO MIR-223-3P.	hsa_circ_0033530	circTDRD9 	hsa_circ_TDRD9	TDRD9	sepsis-induced acute lung injury 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR	"CircTDRD9 is up-regulated in LPS-induced ALI cell models and in serum from ALI patients. It promotes ALI-related inflammatory, oxidative stress, fibrosis and cell growth inhibitory injuries by sponging miR-223-3p and increasing RAB10 expression; knockdown of circTDRD9 has protective effects in vitro."	0.7944
37549012	Advances in clinical and experimental medicine : official organ Wroclaw Medical University	2024	Circular RNA ANKIB1 alleviates hypoxia-induced cardiomyocyte injury by modulating miR-452-5p/SLC7A11 axis.		circANKIB1 	rno_circ_ANKIB1	ANKIB1	Acute myocardial infarction 	MONDO:0004781	acute myocardial infarction	down-regulated	RT-qPCR	"circANKIB1 is decreased in hypoxia-treated rat H9c2 cardiomyocytes and its overexpression protects cells from hypoxia-induced injury. Mechanistically, circANKIB1 sponges miR-452-5p to regulate SLC7A11, thereby suppressing ferroptosis and apoptosis-related injury and suggesting therapeutic relevance for AMI."	0.6683
37549022	"Shock (Augusta, Ga.)"	2023	"CIRC_0002131 CONTRIBUTES TO LPS-INDUCED APOPTOSIS, INFLAMMATION, AND OXIDATIVE INJURY IN HK-2 CELLS VIA INHIBITING THE BINDING BETWEEN MIR-942-5P AND OXSR1."	hsa_circ_0002131	circ_0002131 	hsa_circ_BNIP3L	BNIP3L	sepsis-induced AKI 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR	"circ_0002131 is up-regulated in LPS-treated HK-2 cells and serum from sepsis-related AKI patients. It promotes LPS-induced HK-2 cell apoptosis, inflammation and oxidative injury by sponging miR-942-5p and thereby increasing OXSR1 expression, indicating a pathogenic circ_0002131/miR-942-5p/OXSR1 ceRNA axis in sepsis-induced AKI."	0.7936
37549719	Biochimica et biophysica acta. Molecular basis of disease	2023	The circRNA MKLN1 regulates autophagy in the development of diabetic retinopathy.		chr7:131060183-131084192	hsa_circ_MKLN1	MKLN1	diabetic retinopathy 	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR; RNA-seq	"circMKLN1 is up-regulated in diabetic retinopathy and in HG/MG-treated hRMECs. It promotes endothelial injury and retinal microvascular dysfunction by sponging miR-26a-5p to enhance Rab11a-mediated autophagic flux, and its inhibition ameliorates vascular leakage and acellular vessels in STZ-induced diabetic mice."	0.7846
37549719	Biochimica et biophysica acta. Molecular basis of disease	2023	The circRNA MKLN1 regulates autophagy in the development of diabetic retinopathy.	mmu_circ_0001457	circMkln1 	mmu_circ_Mkln1 	Mkln1 	diabetic retinopathy 	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR; RNA-seq	"circMKLN1 is up-regulated in diabetic retinopathy and in HG/MG-treated hRMECs. It promotes endothelial injury and retinal microvascular dysfunction by sponging miR-26a-5p to enhance Rab11a-mediated autophagic flux, and its inhibition ameliorates vascular leakage and acellular vessels in STZ-induced diabetic mice."	0.7846
37549719	Biochimica et biophysica acta. Molecular basis of disease	2023	The circRNA MKLN1 regulates autophagy in the development of diabetic retinopathy.		circPHKB	hsa_circ_PHKB	PHKB	diabetic retinopathy 	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR; RNA-seq	"circPHKB was identified by extracellular-vesicle RNA sequencing and validated by real-time PCR as up-regulated in individuals with diabetic retinopathy. Its expression also increased in MG-treated hRMECs, but the study did not define a specific mechanism or biological function for circPHKB."	0.429
37553012	Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme	2023	Hsa_circ_0000106 Acts as a Tumor Promoter in Pancreatic Cancer by Targeting the MiR-455-3p/HDAC4.	hsa_circ_0000106	circ_0000106 	hsa_circ_CEPT1	CEPT1	pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"circ_0000106 is up-regulated in pancreatic cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes PC cell proliferation, migration, and xenograft tumor growth by sponging miR-455-3p and thereby regulating HDAC4, suggesting the circ_0000106/miR-455-3p/HDAC4 axis as a potential therapeutic target."	0.7795
37553503	Functional & integrative genomics	2023	CircUSP48 promotes malignant behavior by regulating CYR61 via miR-365 in osteosarcoma.	hsa_circ_0000028	circUSP48 	hsa_circ_USP48	USP48	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"circUSP48/hsa_circ_0000028 is up-regulated in osteosarcoma tissues and cells and promotes malignant phenotypes including proliferation, migration, invasion, colony formation, and tumor growth. Mechanistically, circUSP48 sponges miR-365 to increase CYR61 expression, forming a circUSP48/miR-365/CYR61 axis that contributes to OS progression. Its expression is associated with tumor size and TNM stage, suggesting potential therapeutic relevance."	0.8748
37555585	Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology	2023	CircEpha5 regulates the synthesis and secretion of androgen in mouse preantral follicles by targeting miR-758-5p.	hsa_circ_0126824		hsa_circ_EPHA5	EPHA5	polycystic ovary syndrome 	MONDO:0008487	polycystic ovary syndrome	up-regulated	RT-qPCR; RNA-seq	circEpha5 is up-regulated in PCOS mouse ovaries and is also increased in serum and follicular fluid from PCOS patients. It mainly localizes to the cytoplasm and promotes androgen synthesis/secretion in preantral follicles by sponging miR-758-5p and increasing Cyp17a1 expression. The study suggests circEpha5 may be a potential screening or therapeutic target for PCOS hyperandrogenism.	0.7092
37555585	Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology	2023	CircEpha5 regulates the synthesis and secretion of androgen in mouse preantral follicles by targeting miR-758-5p.	mmu_circ_0001362		mmu_circ_Epha5	Epha5	polycystic ovary syndrome 	MONDO:0008487	polycystic ovary syndrome	up-regulated	RT-qPCR; RNA-seq	circEpha5 is up-regulated in PCOS mouse ovaries and is also increased in serum and follicular fluid from PCOS patients. It mainly localizes to the cytoplasm and promotes androgen synthesis/secretion in preantral follicles by sponging miR-758-5p and increasing Cyp17a1 expression. The study suggests circEpha5 may be a potential screening or therapeutic target for PCOS hyperandrogenism.	0.7092
37560005	American journal of cancer research	2023	"Circular RNA circTIE1 drives proliferation, migration, and invasion of glioma cells through regulating miR-1286/TEAD1 axis."	hsa_circ_0012012	circTIE1 	hsa_circ_TIE1	TIE1	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; RNA-seq	"circTIE1 is up-regulated in glioma tissues and cell lines and increases with WHO grade. It promotes glioma proliferation, migration, invasion/aggression, and tumorigenicity by sponging miR-1286 and upregulating TEAD1. The study proposes circTIE1 as a marker for glioma progression/diagnosis and a potential molecular therapeutic target."	0.8757
37560213	American journal of translational research	2023	Genome-wide screening for circRNAs in epicardial adipose tissue of heart failure patients with preserved ejection fraction.	hsa_circ_0118464	circ_HECW2 	hsa_circ_HECW2	HECW2	Heart failure with preserved ejection fraction 	MONDO:0005252	heart failure	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0118464/circRNA-HECW2 is a human EAT circRNA corresponding to HECW2 that was highly upregulated in HFpEF patients. Its upregulation was supported by RNA sequencing and confirmed by qRT-PCR, but its biological mechanism in HFpEF remains unvalidated."	0.4032
37560213	American journal of translational research	2023	Genome-wide screening for circRNAs in epicardial adipose tissue of heart failure patients with preserved ejection fraction.	hsa_circ_0005583		hsa_circ_ATM	ATM	Heart failure with preserved ejection fraction 	MONDO:0005252	heart failure	dysregulated	RNA-seq	hsa_circ_0005583 was identified from EAT circRNA profiling in HFpEF and was annotated to the ATM gene locus. The study did not validate its expression by qRT-PCR or experimentally test its function.	0.348
37560213	American journal of translational research	2023	Genome-wide screening for circRNAs in epicardial adipose tissue of heart failure patients with preserved ejection fraction.	hsa_circ_0002681				Heart failure with preserved ejection fraction 	MONDO:0005252	heart failure	dysregulated	RNA-seq	"hsa_circ_0002681 was discussed as a differentially expressed EAT circRNA in HFpEF that may modulate CCAR1. The proposed CCAR1-related roles include Wnt signaling, adipogenesis, apoptosis, nuclear receptor function, and DNA damage response, but the study did not experimentally validate this mechanism."	0.348
37560864	Clinical laboratory	2023	"Circ-HMGCS1, an Indicator of Survival and Prognosis in Cervical Cancer Patients."		circ-HMGCS1	hsa_circ_HMGCS1	HMGCS1	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"In cervical cancer, circ-HMGCS1 is up-regulated in tumor tissues and shows strong diagnostic ability to distinguish tumor from adjacent normal tissues. High circ-HMGCS1 expression is associated with tumor size, lymph node metastasis, FIGO stage, and independently predicts worse DFS and OS, supporting its value as a disease monitoring and prognostic biomarker. The downstream molecular mechanism in cervical cancer was not investigated in this study."	0.5918
37561331	Biochemical genetics	2024	Circ_0000370 Plays an Oncogenic Role in Colorectal Cancer by Regulating the miR-502-5p/SIRT1 Axis.	hsa_circ_0000370	circ_0000370	hsa_circ_FLI1	FLI1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"Circ_0000370 is up-regulated in colorectal cancer tissues and cells and functions as an oncogenic circRNA. It promotes CRC proliferation, migration, invasion, metastasis and xenograft tumor growth while inhibiting apoptosis, mainly through sponging miR-502-5p to increase SIRT1 expression. The study suggests circ_0000370 may be a potential therapeutic target for CRC."	0.8005
37561333	Biochemical genetics	2024	MiR-485-3p/MiR-543/MiR-337-3p is Required for the Oncogenic Potential of the Hsa_circ_0007385-MEMO1 Axis in Colorectal Cancer.	hsa_circ_0007385	circ_0007385 	hsa_circ_MEMO1	MEMO1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"hsa_circ_0007385/circ-MEMO1 is up-regulated in colorectal cancer tissues and cell lines. It acts as an oncogenic circRNA that promotes proliferation, migration, invasion, EMT, tumor growth and metastatic progression while suppressing apoptosis. Mechanistically, it functions as a ceRNA for miR-485-3p, miR-543 and miR-337-3p to positively regulate MEMO1 expression, making it a potential therapeutic target for CRC."	0.78
37563361	Cancer gene therapy	2023	m6A-modified circABCC4 promotes stemness and metastasis of prostate cancer by recruiting IGF2BP2 to increase stability of CCAR1.	hsa_circ_0030586	CircABCC4	hsa_circ_ABCC4	ABCC4	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; ISH	"circABCC4 is up-regulated in prostate cancer tissues and cells, and high circABCC4 expression is associated with poor overall survival. METTL3-mediated m6A modification increases circABCC4 expression, and circABCC4 promotes PCa stemness, proliferation, migration, invasion, growth, and metastasis by recruiting IGF2BP2 to stabilize CCAR1 mRNA and activate Wnt/beta-catenin target genes."	0.8871
37565296	Journal of biochemical and molecular toxicology	2023	Circ_LDLR promotes the progression of papillary thyroid carcinoma by regulating miR-1294/HMGB3 axis.		Circ_LDLR 	hsa_circ_LDLR	LDLR	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circ_LDLR is up-regulated in PTC tissues and cell lines and is associated with larger tumor volume, advanced TNM stage and lymph node metastasis. Functionally, circ_LDLR promotes PTC proliferation, migration, invasion, EMT-related changes and xenograft tumor growth by sponging miR-1294 and increasing HMGB3 expression."	0.7785
37565716	Environmental toxicology	2023	CircCRIM1/microRNA-141-3p/thioredoxin-binding protein axis mediates neuronal apoptosis after cerebral ischemia-reperfusion.		CircCRIM1 	mmu_circ_CRIM1	CRIM1	cerebral ischemia-reperfusion injury 	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR	"circCRIM1 is up-regulated in MCAO/R mouse brain tissues and OGD/R-treated SH-SY5Y cells. It promotes CIR-induced neuronal apoptosis and oxidative stress through a ceRNA-like circCRIM1/miR-141-3p/TXNIP axis, while circCRIM1 knockdown alleviates neuronal damage in vivo and in vitro. The axis is proposed as a potential therapeutic target for CIR injury."	0.5637
37566605	Journal of cellular physiology	2023	CircHIPK3 contributes to cisplatin resistance in gastric cancer by blocking autophagy-dependent ferroptosis.		circHIPK3	hsa_circ_HIPK3	HIPK3	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"This study shows that circHIPK3 is upregulated in cisplatin-resistant gastric cancer cells, tissues, and serum exosomes. circHIPK3 promotes cisplatin resistance by sponging miR-508-3p and regulating the Bcl-2/beclin1/SLC7A11 axis, thereby suppressing autophagy-dependent ferroptosis. Serum exosomal circHIPK3 may serve as a noninvasive indicator of cisplatin resistance and therapeutic efficacy in gastric cancer."	0.786
37567009	International immunopharmacology	2023	Hsa_circRNA_103124 upregulation in Crohn's disease promoted macrophage M1 polarization to maintain an inflammatory microenvironment via activation of the AKT2 and TLR4/NF-kappaB pathways.	hsa_circ_0001187	hsa_circRNA_103124 			Crohn's disease 	MONDO:0005011	Crohn disease	up-regulated	RT-qPCR	"In Crohn's disease, hsa_circRNA_103124 is upregulated in PBMCs and inflamed intestinal tissue and correlates positively with CDAI. Mechanistically, it targets hsa-miR-650 and activates AKT2 and TLR4/NF-kappaB signaling, promoting M1 macrophage polarization, inflammatory cytokine production, NET formation, and intestinal epithelial permeability. The study suggests hsa_circRNA_103124 as a potential biomarker and therapeutic target for CD progression."	0.749
37568034	International journal of clinical oncology	2023	The diagnostic potential of two exosome-derived circRNAs for papillary thyroid cancer.	hsa_circ_0082002	hsa_ circ_0082002 	hsa_circ_MET	MET	papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"Exosomal hsa_circ_0082002 is up-regulated in serum from PTC patients and shows diagnostic potential for distinguishing PTC from healthy or benign thyroid tumor groups. Higher levels correlate with lymph node metastasis and vascular invasion, and bioinformatic analyses suggest possible roles through miRNA/RBP interactions and potential protein coding."	0.6841
37568034	International journal of clinical oncology	2023	The diagnostic potential of two exosome-derived circRNAs for papillary thyroid cancer.	hsa_circ_0003863	circ_0003863	hsa_circ_RAB27A	RAB27A	papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"Exosomal hsa_circ_0003863 is up-regulated in serum from PTC patients and has diagnostic value for PTC. Higher levels are associated with lymph node metastasis and vascular invasion, and predicted mechanisms include interactions with miRNAs and RNA binding proteins."	0.6841
37571893	"Cellular and molecular biology (Noisy-le-Grand, France)"	2023	Circular RNA PARG adjusts miR-140-3p to influence progression in sepsis.		circRNA PARG 	hsa_circ_PARG	PARG	sepsis	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR	"circRNA PARG is upregulated in the blood/serum of septic patients and in LPS-stimulated HPMEC models. It localizes to the cytoplasm and interacts with miR-140-3p, promoting inflammatory cytokine expression and apoptosis-related changes during sepsis-associated endothelial injury. Knockdown of circRNA PARG alleviates LPS-induced apoptosis and inflammation, suggesting potential biomarker and therapeutic relevance in sepsis."	0.8034
37575056	American journal of physiology. Cell physiology	2023	CircFOXN2 alleviates glucocorticoid- and tacrolimus-induced dyslipidemia by reducing FASN mRNA stability by binding to PTBP1 during liver transplantation.		circular RNA forkhead box N2	hsa_circ_FOXN2	FOXN2	dyslipidemia after liver transplantation 	MONDO:0700220	disease related to transplantation	down-regulated	RT-qPCR	"circFOXN2 is down-regulated in TAC/Dex-associated dyslipidemia settings and acts protectively against lipid metabolism dysregulation. It binds/recruits PTBP1 to reduce FASN mRNA stability, thereby suppressing FASN-related lipid accumulation and lowering TC and TG levels in Huh-7 cells and a TAC-plus Dex-induced mouse model."	0.7581
37585722	"Hematology (Amsterdam, Netherlands)"	2023	Circ_0001602 aggravates the progression of acute myeloid leukemia by regulating the miR-192-5p/ZBTB20 axis.	hsa_circ_0001602	circ_0001602	hsa_circ_CCND3	CCND3	acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"Circ_0001602 is upregulated in AML bone marrow samples and AML cell lines. It promotes AML cell development by enhancing proliferation and cell cycle progression while suppressing apoptosis, at least partly through sponging miR-192-5p and increasing ZBTB20 expression. The study suggests circ_0001602 as a potential therapeutic target for AML."	0.7936
37589744	Cellular and molecular life sciences : CMLS	2023	AUF1-induced circular RNA hsa_circ_0010467 promotes platinum resistance of ovarian cancer through miR-637/LIF/STAT3 axis.	hsa_circ_0010467		hsa_circ_EIF4G3	EIF4G3	ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"hsa_circ_0010467 is up-regulated in platinum-resistant ovarian cancer tissues, cells, and serum/plasma exosomes, and high expression is associated with advanced tumor stage and poor overall survival. Functionally, it promotes OC cell proliferation, cancer stemness, and cisplatin/platinum resistance. Mechanistically, AUF1 promotes its biogenesis, while hsa_circ_0010467 sponges miR-637 to upregulate LIF and activate STAT3 signaling."	0.8933
37591128	Ecotoxicology and environmental safety	2023	Microglia-derived exosomal circZNRF1 alleviates paraquat-induced neuronal cell damage via miR-17-5p.		circZNRF1 	mmu_circ_ZNRF1	ZNRF1	Parkinson's disease 	MONDO:0005180	Parkinson disease	up-regulated	RT-qPCR; RNA-seq	"Microglia-derived exosomal circZNRF1 is increased after PQ exposure and is transferred to dopaminergic neurons. It protects against PQ-induced neuronal apoptosis by sponging miR-17-5p and regulating the downstream Bcl2/Bax apoptosis-related response, suggesting potential therapeutic relevance for PD."	0.6207
37591128	Ecotoxicology and environmental safety	2023	Microglia-derived exosomal circZNRF1 alleviates paraquat-induced neuronal cell damage via miR-17-5p.	mmu_circ_0015302	circSTED2	mmu_circ_STED2	STED2	Parkinson's disease 	MONDO:0005180	Parkinson disease	up-regulated	RT-qPCR; RNA-seq	"circSTED2 was identified as an upregulated exosomal circRNA in PQ-exposed BV2 microglial exosomes and was validated by qRT-PCR. It was included among FoxO pathway-enriched circRNAs, but the study did not report an individually validated functional mechanism for circSTED2."	0.4276
37591128	Ecotoxicology and environmental safety	2023	Microglia-derived exosomal circZNRF1 alleviates paraquat-induced neuronal cell damage via miR-17-5p.		circCLTB	mmu_circ_CLTB	CLTB	Parkinson's disease 	MONDO:0005180	Parkinson disease	down-regulated	RT-qPCR; RNA-seq	"circCLTB was identified as a novel downregulated exosomal circRNA in PQ-exposed BV2 microglial exosomes and was validated by qRT-PCR. It was included among FoxO pathway-enriched circRNAs, but the study did not report an individually validated functional mechanism for circCLTB."	0.4276
37591128	Ecotoxicology and environmental safety	2023	Microglia-derived exosomal circZNRF1 alleviates paraquat-induced neuronal cell damage via miR-17-5p.	mmu_circ_0001098	circDLGAP4	mmu_circ_DLGAP4	DLGAP4	Parkinson's disease 	MONDO:0005180	Parkinson disease	down-regulated	RT-qPCR; RNA-seq	"circDLGAP4 was identified as a downregulated exosomal circRNA in PQ-exposed BV2 microglial exosomes and was validated by qRT-PCR. It was included among FoxO pathway-enriched circRNAs, but the study did not report an individually validated functional mechanism for circDLGAP4."	0.4276
37591128	Ecotoxicology and environmental safety	2023	Microglia-derived exosomal circZNRF1 alleviates paraquat-induced neuronal cell damage via miR-17-5p.		circKIF1B	mmu_circ_KIF1B	KIF1B	Parkinson's disease 	MONDO:0005180	Parkinson disease	down-regulated	RT-qPCR; RNA-seq	"circKIF1B was identified as a novel downregulated exosomal circRNA in PQ-exposed BV2 microglial exosomes and was validated by qRT-PCR. It was included among FoxO pathway-enriched circRNAs, but the study did not report an individually validated functional mechanism for circKIF1B."	0.4276
37596430	Functional & integrative genomics	2023	Circular RNA circSP5 promotes liver metastasis of colorectal cancer via SP5-mediated BAMBI transcription.	hsa_circ_0057010	circSP5 	hsa_circ_SP5	SP5	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circSP5 is up-regulated in CRC, especially in CRC with liver metastasis, and promotes CRC migration, invasion, EMT, tumor growth, and liver metastasis. Mechanistically, circSP5 sponges miR-1249-3p to enhance SP5 expression, enabling SP5-mediated transcriptional activation of BAMBI. The study suggests circSP5 as a potential biomarker and therapeutic mechanism for CRC liver metastasis."	0.8185
37597108	Molecular neurobiology	2024	Adipose Tissue Exosome circ_sxc Mediates the Modulatory of Adiposomes on Brain Aging by Inhibiting Brain dme-miR-87-3p.		circ_sxc	dme_circ_sxc	sxc	brain aging 			down-regulated	RNA-seq	"The study identifies adipose exosomal circ_sxc as an age-downregulated circRNA in Drosophila adipose exosomes, adipose tissue, and brain. It proposes that circ_sxc is taken up by the brain via adipose tissue exosomes and acts as a sponge for dme-miR-87-3p, thereby maintaining neuroreceptor ligand gene expression and normal synaptic signaling; reduced circ_sxc during aging may contribute to sleep disturbance and brain aging features."	0.3641
37603538	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2023	Exosomal circBBS2 inhibits ferroptosis by targeting miR-494 to activate SLC7A11 signaling in ischemic stroke.	hsa_circ_0039457	CircRNA BBS2 	hsa_circ_BBS2	BBS2	ischemic stroke 	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR	"This study shows that human UC-MSC-derived exosomal circBBS2 is reduced in ischemic stroke models and that exosomal delivery of circBBS2 protects against cerebral ischemia/reperfusion injury. Mechanistically, circBBS2 sponges miR-494 to upregulate SLC7A11, thereby suppressing ferroptosis in H/R-treated SH-SY5Y cells and MCAO-treated rats."	0.809
37603831	"Cell cycle (Georgetown, Tex.)"	2023	circFAM134B is a key factor regulating reticulophagy-mediated ferroptosis in hepatocellular carcinoma.	hsa_circ_0128505	circFAM134B	hsa_circ_FAM134B	FAM134B	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"This study identifies hsa_circ_0128505, abbreviated circFAM134B, as a regulator of lenvatinib-induced ferroptosis in HCC. Mechanistically, circFAM134B competitively binds PABPC4 and affects FAM134B mRNA nonsense-mediated decay, thereby modulating FAM134B-mediated ER-phagy and ferroptotic response. Targeting the circFAM134B-PABPC4-FAM134B axis is proposed as a potential strategy to improve treatment response in liver cancer."	0.7897
37605580	"Cellular and molecular biology (Noisy-le-Grand, France)"	2023	CircZSWIM4 facilitates tumor development in lung adenocarcinoma by targeting miR-370-3p and miR-873-5p to regulate the axis of FOXM1/beta-catenin.		circZSWIM4 	hsa_circ_ZSWIM4	ZSWIM4	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"circZSWIM4 is up-regulated in LUAD cell lines and functions as an oncogenic circRNA. It mainly localizes in the cytoplasm, acts as a ceRNA for miR-370-3p and miR-873-5p to regulate FOXM1 and beta-catenin, activates Wnt/beta-catenin signaling, promotes proliferation, migration and EMT, and suppresses apoptosis. The study proposes circZSWIM4 as a potential biomarker and therapeutic target for LUAD."	0.8233
37606757	Naunyn-Schmiedeberg's archives of pharmacology	2024	"Hsa_circ_0031891 targets miR-579-3p to enhance HMGB1 expression and regulate PDGF-BB-induced human aortic vascular smooth muscle cell proliferation, migration, and dedifferentiation."	hsa_circ_0031891	circ_0031891	hsa_circ_PYGL	PYGL	atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0031891 is up-regulated in CAD patient serum and PDGF-BB-induced HA-VSMCs. It promotes VSMC proliferation, migration, and dedifferentiation by acting as a ceRNA for miR-579-3p and enhancing HMGB1 expression, suggesting a potential therapeutic relevance in AS."	0.7893
37606890	"Shock (Augusta, Ga.)"	2023	CIRC_0085323 SILENCING INHIBITS TNF-alpha-INDUCED NORMAL HUMAN COLONIC EPITHELIAL CELL INFLAMMATION AND APOPTOSIS THROUGH THE MIR-495-3P/TRAF3 AXIS.	hsa_circ_0085323	circ_0085323	hsa_circ_EIF3E	EIF3E	ulcerative colitis 	MONDO:0005101	ulcerative colitis	up-regulated	RT-qPCR; Microarray	"In this UC study, circ_0085323 was up-regulated in colonic mucosal tissues from UC patients and in TNF-alpha-stimulated NCM460 cells. Functionally, circ_0085323 promoted TNF-alpha-induced epithelial cell inflammation and apoptosis and suppressed proliferation, while its knockdown ameliorated cell injury. Mechanistically, circ_0085323 acted as a miR-495-3p sponge to regulate TRAF3 expression, suggesting the circ_0085323/miR-495-3p/TRAF3 axis as a potential therapeutic target for UC."	0.8275
37607407	Analytical chemistry	2023	Triple Amplification Strategy of CHA-PER-DNAzyme for Ultrasensitive Detection of circRNA Associated with Hepatocellular Carcinoma.		circMTO1	hsa_circ_MTO1		hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"This study developed a CHA-PER-DNAzyme fluorescence assay for ultrasensitive and specific detection of circMTO1. circMTO1 was detected at lower levels in HepG2 liver cancer cells and in whole blood from HCC patients compared with controls, supporting its potential clinical utility as an HCC-associated biomarker."	0.2995
37610691	"Cellular oncology (Dordrecht, Netherlands)"	2023	CircGLIS3 inhibits thyroid cancer invasion and metastasis through miR-146b-3p/AIF1L axis.	hsa_circ_0007368		hsa_circ_GLIS3	GLIS3	thyroid carcinoma 	MONDO:0015075	thyroid gland carcinoma	down-regulated	RT-qPCR; RNA-seq	"circGLIS3/hsa_circ_0007368 is a GLIS3-derived human circRNA that is down-regulated in papillary thyroid carcinoma tissues and thyroid cancer cell lines. It suppresses thyroid cancer migration, invasion, EMT and lung metastasis by sponging miR-146b-3p and increasing AIF1L expression. Low circGLIS3 expression is associated with capsular invasion and lymph node metastasis, suggesting diagnostic or prognostic potential."	0.8571
37610692	Biochemical genetics	2024	CircHSPB6 Promotes Tumor-Associated Macrophages M2 Polarization and Infiltration to Accelerate Cell Malignant Properties in Lung Adenocarcinoma by CCL2.	hsa_circ_0050648	circHSPB6	hsa_circ_HSPB6	HSPB6	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circHSPB6/has_circ_0050648 is up-regulated in LUAD tissues and cells and functions as an oncogenic circRNA. It sponges let-7a-2-3p to regulate CCL2, promoting TAM M2 polarization and infiltration, LUAD cell proliferation, migration, invasion and EMT, while suppressing apoptosis. Knockdown of circHSPB6 inhibits malignant phenotypes in vitro and tumor growth in a cell line-derived xenograft model."	0.7898
37615249	Environmental toxicology	2023	CircDLGAP4 induces autophagy and improves endothelial cell dysfunction in atherosclerosis by targeting PTPN4 with miR-134-5p.	hsa_circ_0115089	circDLGAP4 	hsa_circ_DLGAP4	DLGAP4	atherosclerosis 	MONDO:0005311	atherosclerosis	down-regulated	RT-qPCR; Northern Blot; Microarray	"circDLGAP4 is down-regulated in ox-LDL-induced HUVECs and AS patient tissues. The study shows that circDLGAP4 protects against endothelial dysfunction and AS progression by sponging miR-134-5p to upregulate PTPN4, thereby promoting autophagy and reducing apoptosis, inflammation, endothelial barrier dysfunction, and atherosclerotic plaque burden."	0.8355
37620166	Chemical biology & drug design	2023	"Resveratrol alleviates amyloid beta-induced neuronal apoptosis, inflammation, and oxidative and endoplasmic reticulum stress by circ_0050263/miR-361-3p/PDE4A axis during Alzheimer's disease."	hsa_circ_0050263	circ_0050263	hsa_circ_ATP13A1	ATP13A1	Alzheimer's Disease 	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR	"In an Abeta-induced SK-N-SH in vitro Alzheimer's disease model, circ_0050263 is up-regulated and is reduced by resveratrol treatment. Functionally, circ_0050263 promotes neuronal injury phenotypes including apoptosis, inflammatory cytokine production, oxidative stress, and ER stress, and its overexpression counteracts resveratrol-mediated neuroprotection. Mechanistically, circ_0050263 functions as a miR-361-3p sponge to up-regulate PDE4A."	0.7204
37624989	Inflammatory bowel diseases	2023	CircASPH Enhances Exosomal STING to Facilitate M2 Macrophage Polarization in Colorectal Cancer.	hsa_circ_0084615	hsa_circRNA_104634 	hsa_circ_ASPH	ASPH	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq; Microarray	"circASPH is upregulated in colorectal cancer and acts as an oncogenic circRNA. It promotes CRC cell proliferation, migration, invasion and tumor growth, while also enhancing M2 macrophage polarization through an IGF2BP2-dependent stabilization of m6A-modified STING mRNA and exosomal STING transfer."	0.808
37625563	Gene	2023	CircSOD2 polarizes macrophages towards the M1 phenotype to alleviate cisplatin resistance in gastric cancer cells by targeting the miR-1296/STAT1 axis.	hsa_circ_0004662	circSOD2	hsa_circ_SOD2	SOD2	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"CircSOD2 is up-regulated in M1 macrophages and promotes M1 macrophage polarization in gastric cancer-related macrophage models. Mechanistically, cytoplasmic circSOD2 sponges miR-1296 to regulate STAT1, increasing the M1/M2 ratio and enhancing cisplatin-induced apoptosis while reducing cisplatin resistance in gastric cancer cells."	0.8278
37625824	Annals of clinical and laboratory science	2023	Identification of circ_0038632 as a Promoter of Breast Cancer through miR-520a-3p-Dependent Modulation of CDCA3.	hsa_circ_0038632	circ_0038632	hsa_circ_PLK1	PLK1	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0038632 is up-regulated in breast cancer tissues and cell lines and acts as an oncogenic circRNA. It promotes BC cell proliferation, migration, invasion, and xenograft tumor growth while suppressing apoptosis by sponging miR-520a-3p and increasing CDCA3 expression. The study suggests circ_0038632 as a potential therapeutic target for breast cancer."	0.8006
37625838	Annals of clinical and laboratory science	2023	Circ_0088212 Targeting miR-576-5p/FKBP1A Axis Inhibits Osteosarcoma Progression.	hsa_circ_0088212	circ_0088212	hsa_circ_PAPPA	PAPPA	osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; Microarray	"circ_0088212 is downregulated in osteosarcoma tissues and cell lines. Its overexpression suppresses OS proliferation, migration, and xenograft tumor growth while promoting apoptosis. Mechanistically, circ_0088212 functions as a ceRNA for miR-576-5p to positively regulate FKBP1A expression, forming a circ_0088212/miR-576-5p/FKBP1A tumor-suppressive axis."	0.7785
37625840	Annals of clinical and laboratory science	2023	Circular RNA SMARCA5 Promotes a Poor Prognosis and Radiotherapy Resistance for Patients with Hepatocellular Carcinoma.		Circular RNA SMARCA5 	hsa_circ_SMARCA5	SMARCA5	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"This clinical case-control study found that cSMARCA5 is up-regulated in HCC tumor tissues compared with paracancerous tissues. High cSMARCA5 expression is associated with poorer 3-year overall survival and radiotherapy resistance, suggesting potential prognostic and treatment-response value in HCC."	0.4758
37632638	Molecular and cellular biochemistry	2024	Exosomes from circRNA-Ptpn4 can modify ADSC treatment and repair nerve damage caused by cerebral infarction by shifting microglial M1/M2 polarization.		circRNA-Ptpn4 	mmu_circ_Ptpn4	Ptpn4	cerebral infarction 	MONDO:0002679	cerebral infarction	up-regulated	RT-qPCR; RNA-seq	"This study identifies circ-Ptpn4 as an exosomal circRNA enriched in hypoxia-pretreated ADSC-derived exosomes and functionally involved in cerebral infarction repair. Exosomal circ-Ptpn4 improves recovery after MCAO by suppressing miR-153-3p, enhancing Nrf2 expression, reducing inflammatory factors, and promoting microglia/macrophage polarization from M1 to M2."	0.6419
37633479	Cellular signalling	2023	CircTNPO1 promotes the tumorigenesis of osteosarcoma by sequestering miR-578 to upregulate WNT5A expression.	hsa_circ_0072932	circTNPO1	hsa_circ_TNPO1	TNPO1	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"circTNPO1 (hsa_circ_0072932), derived from TNPO1, is up-regulated in osteosarcoma tissues and cells and mainly localized in the cytoplasm. It promotes OS proliferation, invasion, migration, tumor growth and metastasis by sponging miR-578 and thereby upregulating WNT5A. High circTNPO1 expression is associated with tumor size and TNM stage, suggesting potential therapeutic relevance."	0.8772
37641374	"American journal of reproductive immunology (New York, N.Y. : 1989)"	2023	Hsa_circ_0015382 is involved in the pathogenesis of preeclampsia by mediating THBS2 expression.	hsa_circ_0015382		hsa_circ_PAPPA2	PAPPA2	Preeclampsia 	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR	"hsa_circ_0015382 is up-regulated in placental tissues from preeclampsia patients and mainly localized in the cytoplasm. It inhibits trophoblast proliferation, migration, invasion and angiogenesis by acting as a miR-616-3p sponge and increasing THBS2 expression, supporting a role for the hsa_circ_0015382/miR-616-3p/THBS2 ceRNA axis in PE pathogenesis."	0.78
37642813	Biochemical genetics	2024	Circular RNA circ_0058123 Targets the miR-939-5p/RAC1 Pathway to Promote the Development of Colorectal Cancer.	hsa_circ_0058123	circ_0058123 	hsa_circ_FN1	FN1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0058123 is up-regulated in CRC tissues and cell lines and is associated with higher TNM stage. It promotes CRC progression by sponging miR-939-5p and increasing RAC1 expression, thereby enhancing proliferation, migration, invasion, angiogenesis/tube formation, and tumor growth while suppressing apoptosis. The study proposes circ_0058123 as a potential biomarker and therapeutic target for CRC."	0.8169
37642831	Human cell	2023	Circ-SFMBT2 sponges miR-224-5p to induce ketamine-induced cystitis by up-regulating metadherin (MTDH).	hsa_circ_0017639		hsa_circ_SFMBT2	SFMBT2	ketamine-induced cystitis 	MONDO:0006032	cystitis	up-regulated	RT-qPCR; RNA-seq	"circ-SFMBT2 is up-regulated in KIC-associated samples and KIC mouse bladder tissues. It acts as a ceRNA for miR-224-5p, relieving miR-224-5p-mediated repression of MTDH and promoting MTDH expression, which contributes to bladder dysfunction and fibrosis-related changes in KIC. Silencing circ-SFMBT2 restores miR-224-5p activity, reduces MTDH/Collagen I/Collagen III expression, and alleviates bladder functional impairment in KIC mice."	0.8191
37643536	Biochemical and biophysical research communications	2023	Hsa_circ_0000585 promotes chemoresistance to cis-platin in epithelial cells of ovarian cancer by modulating autophagy.	hsa_circ_0000585				ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"Hsa_circ_0000585 is up-regulated in cisplatin-resistant ovarian cancer SKOV3/DDP cells. Functionally, it promotes cell growth, tumor growth, autophagy, and cisplatin chemoresistance; knockdown suppresses autophagy-related changes and enhances cisplatin sensitivity in vitro and in a cell line-derived xenograft model."	0.421
37646218	The International journal of neuroscience	2024	Hsa_circ_0005548 knockdown repairs OGD/R-induced damage in human brain microvascular endothelial cells via miR-362-3p/ETS1 axis.	hsa_circ_0005548		hsa_circ_AMBRA1	aMBRa1	ischemic stroke 	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR	"This study found that hsa_circ_0005548 is up-regulated in OGD/R-treated human brain microvascular endothelial cells. Knockdown of hsa_circ_0005548 alleviates OGD/R-induced injury by promoting proliferation and suppressing apoptosis, inflammation, and LDH release. Mechanistically, hsa_circ_0005548 acts through the miR-362-3p/ETS1 axis and may represent a potential molecular target for ischemic stroke."	0.7626
37646893	Biochemical genetics	2024	"Circular RNA circ_0101675 Promotes NSCLC Cell Proliferation, Migration, Invasion, Angiogenesis and Immune Evasion by Sponging miR-607/PDL1 Axis."	hsa_circ_0101675			NPAS3	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0101675 is upregulated in NSCLC tissues and cells and acts as an oncogenic circRNA. It promotes proliferation, migration, invasion, angiogenesis, immune evasion, and tumor growth by sponging miR-607 and relieving repression of PDL1."	0.8039
37651065	Genes & genomics	2023	Comprehensive analysis of circular RNAs in nasopharyngeal cancer.		circEEF1A1_E8B1 	hsa_circ_EEF1A1	EEF1A1	Nasopharyngeal cancer 	MONDO:0021315	malignant tumor of nasopharynx	up-regulated	RNA-seq	"circEEF1A1_E8B1 was identified by RNA-seq-based bioinformatic analysis as the most enriched circRNA in NPC patients versus controls. The study predicts that it may act through protein-coding potential, microRNA-related target protein networks, and RBP interactions, with enrichment pointing to transcriptional regulation and transcriptional misregulation in cancer."	0.1768
37657244	International immunopharmacology	2023	Exosomal circRNA-001264 promotes AML immunosuppression through induction of M2-like macrophages and PD-L1 overexpression.	hsa_circ_0000086	circRNA-001264 	hsa_circ_ST6GALNAC3	ST6GALNAC3	Acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; ISH; Microarray	"In AML, hsa_circ_001264 is overexpressed in patient samples and AML cell-derived exosomes, and high expression is associated with poor prognosis. Mechanistically, it sponges miR-502-5p to increase RAF1 expression and activate the p38-STAT3 pathway, promoting AML cell proliferation, suppressing apoptosis, inducing M2 macrophage polarization and PD-L1-mediated immunosuppression. Knockdown of exosomal hsa_circ_001264 combined with anti-PD-L1 therapy reduced leukemia burden in vivo."	0.8427
37658248	Molecular neurobiology	2024	Downregulation of circAsxl2 Relieves Neuronal Injury Induced by oxygen-glucose deprivation/reperfusion.	mmu_circ_0000346	circAsxl2 	mmu_circ_Asxl2	Asxl2	cerebral ischemia-reperfusion injury 	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR; Microarray	"This study found that mouse circAsxl2 is up-regulated in OGD/R-induced HT-22 neuronal cells and in GEO-analyzed MCAO/R cerebral cortex tissue. Functionally, circAsxl2 knockdown alleviates OGD/R-induced neuronal injury by reducing apoptosis, inflammation and oxidative stress. Mechanistically, circAsxl2 acts through the miR-130b-5p/FOXO3 axis to promote neuronal injury associated with cerebral ischemia-reperfusion."	0.7435
37661341	Journal of cellular physiology	2023	circAP1M2 activates ATG9A-associated autophagy by inhibiting miR-1249-3p to promote cisplatin resistance in oral squamous cell carcinoma.	hsa_circ_0049282	circAP1M2	hsa_circ_AP1M2	AP1M2	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circAP1M2 (hsa_circ_0049282), derived from the AP1M2 host gene, is up-regulated in OSCC tissues, OSCC cell lines, and cisplatin-resistant OSCC cells. It promotes cisplatin resistance by sponging miR-1249-3p, increasing ATG9A expression, and activating autophagy; knockdown of circAP1M2 restores cisplatin sensitivity in vitro and in a xenograft model."	0.6829
37667097	Biochemical genetics	2024	Hsa_circ_0000069 Accelerates Cervical Cancer Progression by Sponging miR-1270 to Facilitate CPEB4 Expression.	hsa_circ_0000069	circ_0000069	hsa_circ_STIL	STIL	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"Hsa_circ_0000069/circ_0000069 is upregulated in cervical cancer tissues and cell lines and correlates with clinical stage and HPV positivity. Functionally, it promotes malignant phenotypes including proliferation, migration, invasion, tube formation and xenograft tumor growth while suppressing apoptosis. Mechanistically, it acts as a cytoplasmic ceRNA that sponges miR-1270 to increase CPEB4 expression."	0.8572
37667152	Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases	2023	[Expression profile of circular RNA in inflammatory response in human bronchial epithelial cells induced by carbon black nanoparticles].		circ_004661			inflammatory response in human bronchial epithelial cells induced by carbon black nanoparticles 	MONDO:0003781	bronchitis	down-regulated	RT-qPCR; RNA-seq	circ_004661 was significantly down-regulated in 16HBE cells after 80 ug/ml CBNPs exposure for 72 h. It was identified by high-throughput transcriptome sequencing and qRT-PCR as a differentially expressed circRNA associated with CBNPs-induced inflammatory response.	0.1904
37667152	Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases	2023	[Expression profile of circular RNA in inflammatory response in human bronchial epithelial cells induced by carbon black nanoparticles].		circ_001197			inflammatory response in human bronchial epithelial cells induced by carbon black nanoparticles 	MONDO:0003781	bronchitis	down-regulated	RT-qPCR; RNA-seq	circ_001197 was significantly down-regulated in 16HBE cells after 80 ug/ml CBNPs exposure for 72 h. It was identified by high-throughput transcriptome sequencing and qRT-PCR as a differentially expressed circRNA associated with CBNPs-induced inflammatory response.	0.1904
37667152	Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases	2023	[Expression profile of circular RNA in inflammatory response in human bronchial epithelial cells induced by carbon black nanoparticles].		circ_005503			inflammatory response in human bronchial epithelial cells induced by carbon black nanoparticles 	MONDO:0003781	bronchitis	up-regulated	RT-qPCR; RNA-seq	circ_005503 was significantly up-regulated in 16HBE cells after 80 ug/ml CBNPs exposure for 72 h. It was identified by high-throughput transcriptome sequencing and qRT-PCR as a differentially expressed circRNA associated with CBNPs-induced inflammatory response.	0.1904
37667152	Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases	2023	[Expression profile of circular RNA in inflammatory response in human bronchial epithelial cells induced by carbon black nanoparticles].		circ_005306			inflammatory response in human bronchial epithelial cells induced by carbon black nanoparticles 	MONDO:0003781	bronchitis	up-regulated	RT-qPCR; RNA-seq	circ_005306 was significantly up-regulated in 16HBE cells after 80 ug/ml CBNPs exposure for 72 h. It was identified by high-throughput transcriptome sequencing and qRT-PCR as a differentially expressed circRNA associated with CBNPs-induced inflammatory response.	0.1904
37667152	Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases	2023	[Expression profile of circular RNA in inflammatory response in human bronchial epithelial cells induced by carbon black nanoparticles].		circ_002642 	hsa_circ_SMAD2	SMAD2	inflammatory response in human bronchial epithelial cells induced by carbon black nanoparticles 	MONDO:0003781	bronchitis	up-regulated	RT-qPCR; RNA-seq	"circ_002642 was significantly up-regulated in 16HBE cells exposed to 80 ug/ml CBNPs for 72 h and was selected for subsequent circRNA research. The study verified its circular characteristics using RNase R treatment and linked it to CBNPs-induced inflammatory response, with potential relevance to SMAD2 and the NF-kappaB pathway."	0.3401
37673368	Experimental eye research	2023	CircRNA 06209 inhibits cataract development by sponging miR-6848-5p and regulating ALOX15 expression.		rno_circ_06209 	rno_circ_Ptch1	Ptch1	cataract 	MONDO:0005129	cataract	down-regulated	RT-qPCR; RNA-seq	"circRNA 06209 is down-regulated in cataract lenses and functions as an anti-cataract circRNA in selenite-induced rat cataract and H2O2-treated lens epithelial cell models. It promotes cell viability/proliferation and suppresses apoptosis by sponging miR-6848-5p and relieving miR-6848-5p-mediated repression of ALOX15, suggesting potential therapeutic relevance for cataract treatment."	0.8033
37683398	International immunopharmacology	2023	Hsa_circ_0001479 accelerates tumorigenesis of gastric cancer and mediates immune escape.	hsa_circ_0001479		hsa_circ_ZNF131	ZNF131	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001479 is upregulated in gastric cancer and functions as an oncogenic circRNA that promotes GC cell proliferation, migration, invasion, and in vivo tumor growth. Mechanistically, it sponges miR-133a-5p to upregulate DEK and activate Wnt/beta-catenin/c-Myc signaling, while c-Myc further enhances hsa_circ_0001479 generation through ZNF131 promoter activation. The circRNA also contributes to immune escape by reducing CD8 + T cell infiltration and correlating with immune checkpoint molecules, suggesting potential immunotherapy biomarker value."	0.8686
37683904	"Clinical immunology (Orlando, Fla.)"	2023	Circular RNA sequencing identified circARNTL2 as a pathogenic factor in psoriasis by facilitating proliferation and cell cycle progression of keratinocytes.		circARNTL2 	hsa_circ_ARNTL2	ARNTL2	psoriasis 	MONDO:0005083	psoriasis	up-regulated	RT-qPCR; RNA-seq	"circARNTL2 is up-regulated in psoriatic skin lesions and psoriasis-like HaCaT keratinocytes. It promotes keratinocyte viability, proliferation, and G1-to-S cell cycle progression. Mechanistically, circARNTL2 is predominantly cytoplasmic and binds Serpin B4 protein, positively regulating Serpin B4 expression to contribute to psoriasis pathogenesis."	0.8166
37688444	Clinical and experimental pharmacology & physiology	2023	Circ_0002295 facilitated myocardial fibrosis progression through the miR-1287/CXCR2 axis.	rno_circ_0002295	circ_0002295	rno_circ_PTPRG	PTPRG	myocardial fibrosis 	MONDO:0024643	myocardial disorder	up-regulated	RT-qPCR	"circ_0002295 is up-regulated in myocardial fibrosis and promotes fibrosis progression. Its knockdown suppresses cardiac myofibroblast viability/proliferation, migration, and fibrotic marker expression in vitro and alleviates myocardial fibrosis in vivo. Mechanistically, circ_0002295 functions as a sponge for miR-1287 to regulate CXCR2 expression through the circ_0002295/miR-1287/CXCR2 axis."	0.7825
37689284	International journal of biological macromolecules	2023	Proliferation-promoting roles of linear and circular PVT1 are independent of their ability to bind miRNAs in B-cell lymphoma.	hsa_circ_0001821	circPVT1	hsa_circ_PVT1	PVT1	B-cell lymphoma 	MONDO:0015759	B-cell non-Hodgkin lymphoma	up-regulated	RT-qPCR	"circPVT1 is up-regulated in B-cell lymphoma cell lines compared with germinal center B cells. Functional knockdown and overexpression experiments indicate that circPVT1 supports lymphoma cell growth, particularly in BL and in cells with absent or low endogenous circPVT1. The study found no evidence that circPVT1 binds miRNAs in B-cell lymphoma, suggesting that its proliferation-promoting role is independent of a ceRNA mechanism."	0.6471
37689814	Cell death and differentiation	2023	C-IGF1R encoded by cIGF1R acts as a molecular switch to restrict mitophagy of drug-tolerant persister tumour cells in non-small cell lung cancer.	hsa_circ_0005035	circular RNA IGF1R 	hsa_circ_IGF1R	IGF1R	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	"cIGF1R is a human IGF1R-derived circRNA downregulated in tumour tissues and dysregulated after EGFR-TKI exposure. It enhances EGFR-TKI efficacy by binding RHA to suppress IGF1R mRNA splicing and IGF1R signalling, while its encoded peptide C-IGF1R blocks Parkin-mediated VDAC1 ubiquitination to restrict mitophagy and drive DTP tumour cells toward apoptosis."	0.8861
37691430	"Journal of chemotherapy (Florence, Italy)"	2024	CircAGFG1 absence decreases PKM2 expression to enhance oxaliplatin sensitivity in colorectal cancer in a miR-7-5p-dependent manner.		circAGFG1	hsa_circ_AGFG1	AGFG1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circAGFG1 is up-regulated in oxaliplatin-resistant colorectal cancer tissues and cells, and high expression is associated with poor prognosis. Functionally, circAGFG1 promotes glycolysis, proliferation, and L-OHP resistance while suppressing apoptosis. Mechanistically, circAGFG1 regulates PKM2 expression through miR-7-5p, forming a circAGFG1/miR-7-5p/PKM2 axis that affects oxaliplatin sensitivity."	0.8198
37693139	American journal of cancer research	2023	CircCRIM1 suppresses osteosarcoma progression via sponging miR146a-5p and targeting NUMB.	hsa_circ_0002346	CircCRIM1 	hsa_circ_CRIM1	CRIM1	osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; Microarray	"circCRIM1 is a CRIM1-derived human circRNA that is downregulated in osteosarcoma cell lines and mainly localized in the cytoplasm. In this study, circCRIM1 acted as a tumor suppressor by sponging miR146a-5p, increasing NUMB expression, and inhibiting NOTCH signaling, thereby reducing osteosarcoma proliferation, migration, invasion, and xenograft tumor growth."	0.8109
37693148	American journal of cancer research	2023	hsa_circ_0000519 promotes the progression of lung adenocarcinoma through the hsa-miR-1296-5p/DARS axis.	hsa_circ_0000519		hsa_circ_RPPH1	RPPH1	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000519 is upregulated in LUAD tissues and cell lines and correlates with more advanced T grade and TNM stage. It promotes LUAD proliferation, migration, invasion, and xenograft tumor growth by sponging hsa-miR-1296-5p, relieving repression of DARS, and activating the PI3K/AKT/mTOR signaling pathway."	0.8539
37693160	American journal of cancer research	2023	Circular RNA ATP2C1 (has_circ_0005797) sponges miR-432/miR-335 to promote breast cancer progression through regulating CCND1 expression.	hsa_circ_0005797	Circular RNA ATP2C1 	hsa_circ_ATP2C1	ATP2C1	Breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circATP2C1 is up-regulated in breast cancer tissues and cell lines and its high expression is linked to poorer overall survival. Functionally, circATP2C1 promotes BC cell viability, proliferation, invasion, tumor growth and metastasis while suppressing apoptosis. Mechanistically, it functions as a ceRNA by sponging miR-432/miR-335 to increase CCND1 expression."	0.8571
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circASH1L	hsa_circ_ASH1L	ASH1L	bile duct cancer	MONDO:0003059	bile duct cancer	up-regulated	RNA-seq	"circASH1L was identified by bile extracellular vesicle exLR profiling as enriched in malignant cancer samples. It may serve as a diagnostic biomarker to distinguish hepatopancreatobiliary malignant cancers from benign biliary disease, but no functional mechanism was tested for this circRNA."	0.459
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circATP9A	hsa_circ_ATP9A	ATP9A	bile duct cancer	MONDO:0003059	bile duct cancer	up-regulated	RNA-seq	circATP9A was identified in bile extracellular vesicles as enriched in malignant cancer samples and may contribute to a diagnostic circRNA panel. No direct functional or mechanistic experiments were reported for circATP9A.	0.459
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circCLIP1	hsa_circ_CLIP1	CLIP1	bile duct cancer	MONDO:0003059	bile duct cancer	up-regulated	RNA-seq	"circCLIP1 was detected by exLR sequencing and was enriched in bile EV samples from cancer patients. The study proposes it as a potential diagnostic marker, without reporting direct functional assays or a molecular mechanism for this circRNA."	0.459
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circRNF138	hsa_circ_RNF138	RNF138	bile duct cancer	MONDO:0003059	bile duct cancer	up-regulated	RNA-seq	"circRNF138 was one of six bile EV circRNAs reported as enriched in malignant cancer samples. It was proposed as a potential diagnostic biomarker, but the article did not report RT-qPCR validation or functional mechanistic assays specifically for circRNF138."	0.459
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circTIMMDC1	hsa_circ_TIMMDC1	TIMMDC1	bile duct cancer	MONDO:0003059	bile duct cancer	up-regulated	RNA-seq	"circTIMMDC1 was reported as enriched in bile EVs from cancer patients and as part of a circRNA diagnostic marker set. No circTIMMDC1-specific RT-qPCR validation, functional experiments, or mechanistic axis were reported in the main text."	0.459
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circANKRD12	hsa_circ_ANKRD12	ANKRD12	bile duct cancer	MONDO:0003059	bile duct cancer	up-regulated	RT-qPCR; RNA-seq	"circANKRD12 is enriched in bile EVs from malignant cancer patients and was validated by qRT-PCR. Functional knockdown experiments in RBE cholangiocarcinoma cells indicate that circANKRD12 promotes proliferation, migration and invasion, suggesting potential diagnostic and therapeutic relevance, although its molecular mechanism remains unresolved."	0.6616
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circRNF168	hsa_circ_RNF168	RNF168	bile duct cancer	MONDO:0003059	bile duct cancer	up-regulated	RT-qPCR; RNA-seq	"circRNF168 is enriched in bile EV samples from cancer patients and was validated by qRT-PCR. Knockdown of circRNF168 reduced proliferation, migration and invasion of RBE cholangiocarcinoma cells, suggesting a pro-tumor role and possible therapeutic relevance, while its detailed molecular mechanism was not defined."	0.5923
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circASH1L	hsa_circ_ASH1L	ASH1L	cholangiocarcinoma	MONDO:0019087	cholangiocarcinoma	up-regulated	RNA-seq	"circASH1L was identified by bile extracellular vesicle exLR profiling as enriched in malignant cancer samples. It may serve as a diagnostic biomarker to distinguish hepatopancreatobiliary malignant cancers from benign biliary disease, but no functional mechanism was tested for this circRNA."	0.459
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circATP9A	hsa_circ_ATP9A	ATP9A	cholangiocarcinoma	MONDO:0019087	cholangiocarcinoma	up-regulated	RNA-seq	circATP9A was identified in bile extracellular vesicles as enriched in malignant cancer samples and may contribute to a diagnostic circRNA panel. No direct functional or mechanistic experiments were reported for circATP9A.	0.459
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circCLIP1	hsa_circ_CLIP1	CLIP1	cholangiocarcinoma	MONDO:0019087	cholangiocarcinoma	up-regulated	RNA-seq	"circCLIP1 was detected by exLR sequencing and was enriched in bile EV samples from cancer patients. The study proposes it as a potential diagnostic marker, without reporting direct functional assays or a molecular mechanism for this circRNA."	0.459
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circRNF138	hsa_circ_RNF138	RNF138	cholangiocarcinoma	MONDO:0019087	cholangiocarcinoma	up-regulated	RNA-seq	"circRNF138 was one of six bile EV circRNAs reported as enriched in malignant cancer samples. It was proposed as a potential diagnostic biomarker, but the article did not report RT-qPCR validation or functional mechanistic assays specifically for circRNF138."	0.459
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circTIMMDC1	hsa_circ_TIMMDC1	TIMMDC1	cholangiocarcinoma	MONDO:0019087	cholangiocarcinoma	up-regulated	RNA-seq	"circTIMMDC1 was reported as enriched in bile EVs from cancer patients and as part of a circRNA diagnostic marker set. No circTIMMDC1-specific RT-qPCR validation, functional experiments, or mechanistic axis were reported in the main text."	0.459
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circANKRD12	hsa_circ_ANKRD12	ANKRD12	cholangiocarcinoma	MONDO:0019087	cholangiocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circANKRD12 is enriched in bile EVs from malignant cancer patients and was validated by qRT-PCR. Functional knockdown experiments in RBE cholangiocarcinoma cells indicate that circANKRD12 promotes proliferation, migration and invasion, suggesting potential diagnostic and therapeutic relevance, although its molecular mechanism remains unresolved."	0.6616
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circRNF168	hsa_circ_RNF168	RNF168	cholangiocarcinoma	MONDO:0019087	cholangiocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circRNF168 is enriched in bile EV samples from cancer patients and was validated by qRT-PCR. Knockdown of circRNF168 reduced proliferation, migration and invasion of RBE cholangiocarcinoma cells, suggesting a pro-tumor role and possible therapeutic relevance, while its detailed molecular mechanism was not defined."	0.5923
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circASH1L	hsa_circ_ASH1L	ASH1L	gallbladder carcinoma	MONDO:0003220	gallbladder carcinoma	up-regulated	RNA-seq	"circASH1L was identified by bile extracellular vesicle exLR profiling as enriched in malignant cancer samples. It may serve as a diagnostic biomarker to distinguish hepatopancreatobiliary malignant cancers from benign biliary disease, but no functional mechanism was tested for this circRNA."	0.459
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circATP9A	hsa_circ_ATP9A	ATP9A	gallbladder carcinoma	MONDO:0003220	gallbladder carcinoma	up-regulated	RNA-seq	circATP9A was identified in bile extracellular vesicles as enriched in malignant cancer samples and may contribute to a diagnostic circRNA panel. No direct functional or mechanistic experiments were reported for circATP9A.	0.459
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circCLIP1	hsa_circ_CLIP1	CLIP1	gallbladder carcinoma	MONDO:0003220	gallbladder carcinoma	up-regulated	RNA-seq	"circCLIP1 was detected by exLR sequencing and was enriched in bile EV samples from cancer patients. The study proposes it as a potential diagnostic marker, without reporting direct functional assays or a molecular mechanism for this circRNA."	0.459
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circRNF138	hsa_circ_RNF138	RNF138	gallbladder carcinoma	MONDO:0003220	gallbladder carcinoma	up-regulated	RNA-seq	"circRNF138 was one of six bile EV circRNAs reported as enriched in malignant cancer samples. It was proposed as a potential diagnostic biomarker, but the article did not report RT-qPCR validation or functional mechanistic assays specifically for circRNF138."	0.459
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circTIMMDC1	hsa_circ_TIMMDC1	TIMMDC1	gallbladder carcinoma	MONDO:0003220	gallbladder carcinoma	up-regulated	RNA-seq	"circTIMMDC1 was reported as enriched in bile EVs from cancer patients and as part of a circRNA diagnostic marker set. No circTIMMDC1-specific RT-qPCR validation, functional experiments, or mechanistic axis were reported in the main text."	0.459
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circANKRD12	hsa_circ_ANKRD12	ANKRD12	gallbladder carcinoma	MONDO:0003220	gallbladder carcinoma	up-regulated	RT-qPCR; RNA-seq	"circANKRD12 is enriched in bile EVs from malignant cancer patients and was validated by qRT-PCR. Functional knockdown experiments in RBE cholangiocarcinoma cells indicate that circANKRD12 promotes proliferation, migration and invasion, suggesting potential diagnostic and therapeutic relevance, although its molecular mechanism remains unresolved."	0.6616
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circRNF168	hsa_circ_RNF168	RNF168	gallbladder carcinoma	MONDO:0003220	gallbladder carcinoma	up-regulated	RT-qPCR; RNA-seq	"circRNF168 is enriched in bile EV samples from cancer patients and was validated by qRT-PCR. Knockdown of circRNF168 reduced proliferation, migration and invasion of RBE cholangiocarcinoma cells, suggesting a pro-tumor role and possible therapeutic relevance, while its detailed molecular mechanism was not defined."	0.5923
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circASH1L	hsa_circ_ASH1L	ASH1L	pancreatic adenocarcinoma	MONDO:0006047	pancreatic adenocarcinoma	up-regulated	RNA-seq	"circASH1L was identified by bile extracellular vesicle exLR profiling as enriched in malignant cancer samples. It may serve as a diagnostic biomarker to distinguish hepatopancreatobiliary malignant cancers from benign biliary disease, but no functional mechanism was tested for this circRNA."	0.459
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circATP9A	hsa_circ_ATP9A	ATP9A	pancreatic adenocarcinoma	MONDO:0006047	pancreatic adenocarcinoma	up-regulated	RNA-seq	circATP9A was identified in bile extracellular vesicles as enriched in malignant cancer samples and may contribute to a diagnostic circRNA panel. No direct functional or mechanistic experiments were reported for circATP9A.	0.459
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circCLIP1	hsa_circ_CLIP1	CLIP1	pancreatic adenocarcinoma	MONDO:0006047	pancreatic adenocarcinoma	up-regulated	RNA-seq	"circCLIP1 was detected by exLR sequencing and was enriched in bile EV samples from cancer patients. The study proposes it as a potential diagnostic marker, without reporting direct functional assays or a molecular mechanism for this circRNA."	0.459
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circRNF138	hsa_circ_RNF138	RNF138	pancreatic adenocarcinoma	MONDO:0006047	pancreatic adenocarcinoma	up-regulated	RNA-seq	"circRNF138 was one of six bile EV circRNAs reported as enriched in malignant cancer samples. It was proposed as a potential diagnostic biomarker, but the article did not report RT-qPCR validation or functional mechanistic assays specifically for circRNF138."	0.459
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circTIMMDC1	hsa_circ_TIMMDC1	TIMMDC1	pancreatic adenocarcinoma	MONDO:0006047	pancreatic adenocarcinoma	up-regulated	RNA-seq	"circTIMMDC1 was reported as enriched in bile EVs from cancer patients and as part of a circRNA diagnostic marker set. No circTIMMDC1-specific RT-qPCR validation, functional experiments, or mechanistic axis were reported in the main text."	0.459
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circANKRD12	hsa_circ_ANKRD12	ANKRD12	pancreatic adenocarcinoma	MONDO:0006047	pancreatic adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circANKRD12 is enriched in bile EVs from malignant cancer patients and was validated by qRT-PCR. Functional knockdown experiments in RBE cholangiocarcinoma cells indicate that circANKRD12 promotes proliferation, migration and invasion, suggesting potential diagnostic and therapeutic relevance, although its molecular mechanism remains unresolved."	0.6616
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circRNF168	hsa_circ_RNF168	RNF168	pancreatic adenocarcinoma	MONDO:0006047	pancreatic adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circRNF168 is enriched in bile EV samples from cancer patients and was validated by qRT-PCR. Knockdown of circRNF168 reduced proliferation, migration and invasion of RBE cholangiocarcinoma cells, suggesting a pro-tumor role and possible therapeutic relevance, while its detailed molecular mechanism was not defined."	0.5923
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circASH1L	hsa_circ_ASH1L	ASH1L	periampullary adenocarcinoma	MONDO:0004465	periampullary adenocarcinoma	up-regulated	RNA-seq	"circASH1L was identified by bile extracellular vesicle exLR profiling as enriched in malignant cancer samples. It may serve as a diagnostic biomarker to distinguish hepatopancreatobiliary malignant cancers from benign biliary disease, but no functional mechanism was tested for this circRNA."	0.459
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circATP9A	hsa_circ_ATP9A	ATP9A	periampullary adenocarcinoma	MONDO:0004465	periampullary adenocarcinoma	up-regulated	RNA-seq	circATP9A was identified in bile extracellular vesicles as enriched in malignant cancer samples and may contribute to a diagnostic circRNA panel. No direct functional or mechanistic experiments were reported for circATP9A.	0.459
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circCLIP1	hsa_circ_CLIP1	CLIP1	periampullary adenocarcinoma	MONDO:0004465	periampullary adenocarcinoma	up-regulated	RNA-seq	"circCLIP1 was detected by exLR sequencing and was enriched in bile EV samples from cancer patients. The study proposes it as a potential diagnostic marker, without reporting direct functional assays or a molecular mechanism for this circRNA."	0.459
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circRNF138	hsa_circ_RNF138	RNF138	periampullary adenocarcinoma	MONDO:0004465	periampullary adenocarcinoma	up-regulated	RNA-seq	"circRNF138 was one of six bile EV circRNAs reported as enriched in malignant cancer samples. It was proposed as a potential diagnostic biomarker, but the article did not report RT-qPCR validation or functional mechanistic assays specifically for circRNF138."	0.459
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circTIMMDC1	hsa_circ_TIMMDC1	TIMMDC1	periampullary adenocarcinoma	MONDO:0004465	periampullary adenocarcinoma	up-regulated	RNA-seq	"circTIMMDC1 was reported as enriched in bile EVs from cancer patients and as part of a circRNA diagnostic marker set. No circTIMMDC1-specific RT-qPCR validation, functional experiments, or mechanistic axis were reported in the main text."	0.459
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circANKRD12	hsa_circ_ANKRD12	ANKRD12	periampullary adenocarcinoma	MONDO:0004465	periampullary adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circANKRD12 is enriched in bile EVs from malignant cancer patients and was validated by qRT-PCR. Functional knockdown experiments in RBE cholangiocarcinoma cells indicate that circANKRD12 promotes proliferation, migration and invasion, suggesting potential diagnostic and therapeutic relevance, although its molecular mechanism remains unresolved."	0.6616
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circRNF168	hsa_circ_RNF168	RNF168	periampullary adenocarcinoma	MONDO:0004465	periampullary adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circRNF168 is enriched in bile EV samples from cancer patients and was validated by qRT-PCR. Knockdown of circRNF168 reduced proliferation, migration and invasion of RBE cholangiocarcinoma cells, suggesting a pro-tumor role and possible therapeutic relevance, while its detailed molecular mechanism was not defined."	0.5923
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circASH1L	hsa_circ_ASH1L	ASH1L	colorectal cancer	MONDO:0005575	colorectal cancer	up-regulated	RNA-seq	"circASH1L was identified by bile extracellular vesicle exLR profiling as enriched in malignant cancer samples. It may serve as a diagnostic biomarker to distinguish hepatopancreatobiliary malignant cancers from benign biliary disease, but no functional mechanism was tested for this circRNA."	0.459
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circATP9A	hsa_circ_ATP9A	ATP9A	colorectal cancer	MONDO:0005575	colorectal cancer	up-regulated	RNA-seq	circATP9A was identified in bile extracellular vesicles as enriched in malignant cancer samples and may contribute to a diagnostic circRNA panel. No direct functional or mechanistic experiments were reported for circATP9A.	0.459
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circCLIP1	hsa_circ_CLIP1	CLIP1	colorectal cancer	MONDO:0005575	colorectal cancer	up-regulated	RNA-seq	"circCLIP1 was detected by exLR sequencing and was enriched in bile EV samples from cancer patients. The study proposes it as a potential diagnostic marker, without reporting direct functional assays or a molecular mechanism for this circRNA."	0.459
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circRNF138	hsa_circ_RNF138	RNF138	colorectal cancer	MONDO:0005575	colorectal cancer	up-regulated	RNA-seq	"circRNF138 was one of six bile EV circRNAs reported as enriched in malignant cancer samples. It was proposed as a potential diagnostic biomarker, but the article did not report RT-qPCR validation or functional mechanistic assays specifically for circRNF138."	0.459
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circTIMMDC1	hsa_circ_TIMMDC1	TIMMDC1	colorectal cancer	MONDO:0005575	colorectal cancer	up-regulated	RNA-seq	"circTIMMDC1 was reported as enriched in bile EVs from cancer patients and as part of a circRNA diagnostic marker set. No circTIMMDC1-specific RT-qPCR validation, functional experiments, or mechanistic axis were reported in the main text."	0.459
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circANKRD12	hsa_circ_ANKRD12	ANKRD12	colorectal cancer	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"circANKRD12 is enriched in bile EVs from malignant cancer patients and was validated by qRT-PCR. Functional knockdown experiments in RBE cholangiocarcinoma cells indicate that circANKRD12 promotes proliferation, migration and invasion, suggesting potential diagnostic and therapeutic relevance, although its molecular mechanism remains unresolved."	0.6616
37696683	Carcinogenesis	2023	"Extracellular vesicles long RNA profiling identifies abundant mRNA, circRNA and lncRNA in human bile as potential biomarkers for cancer diagnosis."		circRNF168	hsa_circ_RNF168	RNF168	colorectal cancer	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"circRNF168 is enriched in bile EV samples from cancer patients and was validated by qRT-PCR. Knockdown of circRNF168 reduced proliferation, migration and invasion of RBE cholangiocarcinoma cells, suggesting a pro-tumor role and possible therapeutic relevance, while its detailed molecular mechanism was not defined."	0.5923
37697064	Oncogene	2023	Circular RNA EIF3I promotes papillary thyroid cancer progression by interacting with AUF1 to increase Cyclin D1 production.	hsa_circ_0011385	circular eukaryotic translation initiation factor 3 subunit I 	hsa_circ_EIF3I	EIF3I	papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"circEIF3I (hsa_circ_0011385) is upregulated in papillary thyroid cancer tissues and primarily localizes to the cytoplasm. It promotes PTC cell proliferation, cell-cycle progression, migration, invasion, and xenograft tumor growth. Mechanistically, circEIF3I binds AUF1 and reduces AUF1-mediated Cyclin D1 mRNA degradation, thereby increasing Cyclin D1 protein production and driving PTC progression."	0.8541
37698761	Biochemical genetics	2024	CircRNA_0088196 Regulates Trophoblast Proliferation and Apoptosis in Preeclampsia Through the miR-379-5p/HSPA5 Axis.	hsa_circ_0088196	circRNA_0088196 	hsa_circ_TNC	TNC	preeclampsia 	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR	"circRNA_0088196 is up-regulated in human preeclampsia placental tissue and in HSPA5-stimulated trophoblast cells. It sponges miR-379-5p to increase HSPA5 expression, thereby inhibiting trophoblast proliferation and invasion, promoting apoptosis, and inducing G0/G1 phase arrest. The study suggests circRNA_0088196 as a potential biomarker and therapeutic target for PE."	0.6285
37702682	Clinical laboratory	2023	"Circ_0020123, a New Circular RNA Biomarker for Deep Vein Thrombosis in Pregnant Women."	hsa_circ_0020123	circ_0020123	hsa_circ_PDZD8	PDZD8	deep vein thrombosis 	MONDO:0000831	thrombotic disease	up-regulated	RT-qPCR; Microarray	"circ_0020123 is up-regulated in serum from pregnant women with DVT and in ox-LDL-treated HUVECs. The study identifies increased circ_0020123 as an independent risk factor and new biomarker for DVT in pregnant women, and functionally shows that circ_0020123 aggravates endothelial cell injury by inhibiting proliferation, angiogenesis, and migration while promoting apoptosis, oxidative stress, inflammation, and thrombosis-related factors."	0.7223
37702882	Molecular biotechnology	2024	CircRNA PGAM1 Promotes the Migration and Invasion of Pancreatic Adenocarcinoma Cells by Activating the AKT/mTOR Signaling Pathway.		circPGAM1 	hsa_circ_PGAM1	PGAM1	Pancreatic adenocarcinoma 	MONDO:0006047	pancreatic adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circPGAM1 is up-regulated in pancreatic adenocarcinoma and is associated with poor overall and disease-free survival. Functionally, circPGAM1 promotes PAAD cell proliferation, migration, and invasion. Mechanistically, it activates the AKT/mTOR signaling pathway, and AKT inhibition with AZD5363 reverses circPGAM1-induced pathway activation and metastatic phenotypes."	0.5732
37709179	Fish & shellfish immunology	2023	CircRNA254 functions as the miR-375 sponge to inhibit coelomocyte apoptosis via targeting BAG2 in V. splendidus-challenged Apostichopus japonicus.		circRNA254 	Aja_circ_AjMEGF6	AjMEGF6	skin ulceration syndrome 	MONDO:0010208	wrinkly skin syndrome	down-regulated	RT-qPCR; RNA-seq	"circ254 is down-regulated in A. japonicus coelomocytes after V. splendidus challenge and LPS stimulation, consistent with RNA-seq findings in skin ulceration syndrome. It primarily localizes to the cytoplasm and functions as a miR-375 sponge, promoting AjBAG2 expression and suppressing pathogen-induced coelomocyte apoptosis."	0.7924
37713785	International immunopharmacology	2023	m6A-modified circNFIX promotes ovarian cancer progression and immune escape via activating IL-6R/JAK1/STAT3 signaling by sponging miR-647.		circNFIX 	hsa_circ_NFIX	NFIX	ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circNFIX is upregulated in ovarian cancer tissues and cell lines, and high circNFIX expression is associated with metastasis, advanced stage and poor prognosis. Mechanistically, m6A-modified circNFIX is maintained by IGF2BP1/2/3 recognition and promotes OC progression and immune escape by sponging miR-647 to upregulate IL-6R, activate JAK1/STAT3 signaling and increase PD-L1 expression."	0.8148
37715374	"Cellular and molecular biology (Noisy-le-Grand, France)"	2023	Circ-PRMT5 stimulates the proliferative ability in Wilms' tumor through the miR-7-5p/KLF4 axis.		circ-PRMT5	hsa_circ_PRMT5	PRMT5	Wilms' tumor 	MONDO:0006058	Wilms tumor	up-regulated	RT-qPCR	"Circ-PRMT5 is upregulated in Wilms' tumor tissues and cells, and higher expression is associated with advanced tumor staging. Functionally, circ-PRMT5 promotes Wilms' tumor cell proliferation, at least partly through regulation of the miR-7-5p/KLF4 axis."	0.6521
37715433	"Cellular and molecular biology (Noisy-le-Grand, France)"	2023	Circ_0006251 mediates the proliferation and apoptosis of vascular smooth muscle cells in CAD via enhancing TET3 and PPM1B expression.	hsa_circ_0006251	circ_0006251	hsa_circ_TET3	TET3	coronary artery disease 	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR	"In this study, circ_0006251 is up-regulated in PDGF-BB-induced VSMCs, an in vitro CAD-like model. circ_0006251 promotes VSMC proliferation, migration and invasion and suppresses apoptosis, at least partly by sponging miR-361-3p to increase TET3 and PPM1B expression. The authors propose circ_0006251 as a potential diagnostic and therapeutic biomarker for CAD."	0.8093
37715994	Acta biochimica Polonica	2023	Circular RNA METTL15/miR-374a-5p/ESCO2 axis induces colorectal cancer development.		circMETTL15 	hsa_circ_METTL15	METTL15	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circMETTL15 is up-regulated in colorectal cancer tissues and cell lines and high expression is associated with adverse clinicopathological features and poor overall survival. Functionally, circMETTL15 promotes CRC cell proliferation, invasion, migration, EMT and tumor growth while inhibiting apoptosis. Mechanistically, it acts as a ceRNA for miR-374a-5p to increase ESCO2 expression."	0.8593
37717099	Oncogene	2023	Downregulated circPOKE promotes breast cancer metastasis through activation of the USP10-Snail axis.	hsa_circ_0000875	circPOKE	hsa_circ_ZBTB7A	ZBTB7A	breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; ISH	"circPOKE is a human ZBTB7A-derived circular RNA that is downregulated in breast cancer and more strongly reduced in metastatic disease. It suppresses breast cancer migration, invasion, EMT, stemness and metastasis by competitively binding USP10 and promoting ubiquitin-mediated degradation of Snail. circPOKE can also be secreted in exosomes, and exosome-carried circPOKE attenuates lung metastasis, supporting its potential as a therapeutic inhibitor for metastatic breast cancer."	0.8729
37722005	Acta biochimica Polonica	2023	Circular RNA CSPP1 motivates renal cell carcinoma carcinogenesis and the Warburg effect by targeting RAC1 through microRNA-493-5p.		circ-CSPP1	hsa_circ_CSPP1	CSPP1	renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR	"Circ-CSPP1 is up-regulated in RCC tissues and cell lines and high expression predicts poor overall survival. Functionally, circ-CSPP1 promotes RCC cell proliferation, migration, invasion, and Warburg effect while suppressing apoptosis. Mechanistically, it acts as a ceRNA sponge for miR-493-5p to upregulate RAC1."	0.7408
37722013	Acta biochimica Polonica	2023	"Circ-PGPEP1 augments renal cell carcinoma proliferation, Warburg effect, and distant metastasis."		circPGPEP1 	hsa_circ_PGPEP1	PGPEP1	renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR	"circPGPEP1 is up-regulated in RCC tissues and cell lines and is associated with high histological grade, distant metastasis, and poor survival. Mechanistically, cytoplasmic circPGPEP1 sponges miR-378a-3p to increase JPT1 expression, thereby promoting RCC proliferation, invasion, migration, EMT, Warburg effect, tumor growth, and distant metastasis."	0.8658
37724157	Reports of biochemistry & molecular biology	2023	"Regulatory Role of circRNA-0067835 in Behcet Disease through Targeting Micro RNA-155: Implication of ATG1, AKT and MTOR."	hsa_circ_0067835	circRNA-0067835 			Behcet Disease 	MONDO:0007191	Behcet disease	up-regulated	RT-qPCR	"This clinical study found that serum circRNA-0067835 is significantly upregulated in Behcet Disease and is positively associated with disease severity. The authors propose that circRNA-0067835 sequesters miRNA-155, thereby increasing TAB2 and pro-inflammatory cytokine production through dysregulated autophagy involving the mTOR/AKT pathway, suggesting diagnostic and therapeutic potential."	0.4128
37724521	Autoimmunity	2023	Circ_0007535 upregulates TGFBR1 to promote pulmonary fibrosis in TGF-beta1-treated lung fibroblasts via sequestering miR-18a-5p.	hsa_circ_0007535	circ_0007535			pulmonary fibrosis	MONDO:0002771	pulmonary fibrosis	up-regulated	RT-qPCR	"circ_0007535 is up-regulated in lung tissues from pulmonary fibrosis patients and in TGF-beta1-treated HFL1 lung fibroblasts. It promotes profibrotic cellular phenotypes, including proliferation, migration, invasion, EMT, ECM accumulation and inflammation, by sponging miR-18a-5p and upregulating TGFBR1."	0.7982
37724530	Autoimmunity	2023	CircFLNA/miR-214 modulates regulatory T cells by regulating PD-1 in acute lung injury induced by sepsis.	hsa_circ_0092012	circFLNA 	hsa_circ_FLNA	FLNA	sepsis-induced acute respiratory distress syndrome 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR	"circFLNA is up-regulated in BALF from patients with sepsis-induced ARDS and in CLP-induced ARDS mouse samples. Functionally, circFLNA depletion alleviates inflammatory responses and increases CD4 + CD25 + Foxp3 + Tregs. Mechanistically, circFLNA binds miR-214-5p and regulates the downstream target PD-1, forming a circFLNA/miR-214-5p/PD-1 axis relevant to immune regulation in ARDS."	0.8429
37726500	Sleep & breathing = Schlaf & Atmung	2024	The role of exosomal circular RNA ZNF292 in intermittent hypoxia-induced AC16 cardiomyocytes injury.		exosomal circular RNA ZNF292 	hsa_circ_ZNF292	ZNF292	obstructive sleep apnea 	MONDO:0007147	obstructive sleep apnea syndrome	down-regulated	RT-qPCR	"In an in vitro model of intermittent hypoxia-induced AC16 cardiomyocyte injury, exosomal circZNF292 was down-regulated. The study supports a protective role for exosomal circZNF292, because its knockdown increased miR-146a-5p, reduced the anti-apoptotic context linked to XIAP, and aggravated cardiomyocyte apoptosis. The authors propose the exosomal circZNF292/miR-146a-5p/XIAP pathway as a potential biomarker and therapeutic target in OSA-associated cardiovascular disease."	0.5554
37728841	Molecular biotechnology	2024	CircPRRC2C Promotes the Oncogenic Phenotypes of Laryngeal Squamous Cell Carcinoma Cells via MiR-136-5p/HOXD11 Axis.	hsa_circ_0015211	circPRRC2C 	hsa_circ_PRRC2C	PRRC2C	laryngeal squamous cell carcinoma 	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"CircPRRC2C/hsa_circ_0015211 is an up-regulated PRRC2C-derived circRNA in LSCC tissues, cell lines and patient-derived exosomes. It promotes LSCC proliferation, migration, invasion and xenograft growth while inhibiting apoptosis, mainly by sponging miR-136-5p to increase HOXD11 expression. Exosomal circPRRC2C also shows diagnostic biomarker potential for LSCC."	0.8768
37730964	Biochemical genetics	2024	Exosomal circKIAA1797 Regulates Cell Progression and Glycolysis by Targeting miR-4429/PBX3 Pathway in Gastric Cancer.	hsa_circ_0003537	circKIAA1797 	hsa_circ_KIAA1797	KIAA1797	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"Exosomal circKIAA1797 is up-regulated in gastric cancer tissues, cells, and serum-derived exosomes. It promotes GC malignant phenotypes, glycolysis, and tumor growth by sponging miR-4429 and up-regulating PBX3, while its knockdown suppresses proliferation, migration, invasion, glycolytic metabolism and enhances apoptosis. The study suggests exosomal circKIAA1797 as a potential therapeutic target for GC."	0.7294
37730966	Biochemical genetics	2024	Circ_0005785 Silencing Constrains the Functional Properties of Colorectal Cancer Cells Depending on miR-7-5p/DNMT3A Axis.	hsa_circ_0005785	circ_0005785 	hsa_circ_ANAPC7	ANAPC7	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"Circ_0005785 is up-regulated in CRC tissues and cell lines, and high expression is associated with poor overall survival. Functionally, circ_0005785 promotes CRC proliferation, invasion, angiogenesis, EMT and in vivo tumor growth while inhibiting apoptosis. Mechanistically, it sponges miR-7-5p to increase DNMT3A expression, forming a circ_0005785/miR-7-5p/DNMT3A regulatory axis."	0.7892
37730967	Biochemical genetics	2024	Resveratrol Inhibits circ_0074371-related Pathway to Alleviate Sepsis-induced Acute Kidney Injury.	hsa_circ_0074371	circ_0074371	hsa_circ_ARHGAP26	ARHGAP26	sepsis-induced acute kidney injury 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR	"circ_0074371 is upregulated in septic AKI and acts as a pro-injury circRNA in LPS-stimulated HK2 cells. It sponges miR-145-5p to increase IPMK, thereby promoting apoptosis, inflammation, oxidative stress and inhibiting cell proliferation; resveratrol alleviates injury partly by suppressing this circ_0074371/miR-145-5p/IPMK axis."	0.7223
37735991	British poultry science	2023	Identification and functional analysis of circRIPK2 in lipopolysaccharide induced chicken macrophages.		circular RIPK2 	gga_circ_RIPK2	RIPK2	bacterial infection 	MONDO:0005113	bacterial infectious disease	up-regulated	RNA-seq	"Chicken circRIPK2 is a stable circular RNA derived from exons 4 to 9 of RIPK2 and enriched in the cytoplasm. It is up-regulated after avian pathogenic E. coli infection and promotes LPS-induced macrophage injury by reducing cell viability and increasing pro-inflammatory cytokine and apoptosis gene expression. In silico analysis predicted that circRIPK2 interacts with six miRNAs and regulates target genes enriched in immune- and signaling-related pathways including Wnt, adherens junction, and NOD-like receptor signaling."	0.6862
37738681	Carcinogenesis	2023	m6A-modified circASXL1 promotes proliferation and migration of ovarian cancer through the miR-320d/RACGAP1 axis.	hsa_circ_0059789	circASXL1 	hsa_circ_ASXL1	ASXL1	ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circASXL1 is up-regulated in ovarian cancer tissues and cells, and high expression is associated with poor prognosis. METTL3/IGF2BP1-mediated m6A modification stabilizes circASXL1, which promotes proliferation, migration, invasion, and xenograft tumor growth by sponging miR-320d to increase RACGAP1 and activate PI3K/Akt signaling."	0.8438
37740139	Cardiovascular toxicology	2023	Salidroside Ameliorates Ischemia/Reperfusion-Induced Human Cardiomyocyte Injury by Inhibiting the Circ_0097682/miR-671-5p/USP46 Pathway.	hsa_circ_0097682	circ_0097682			myocardial infarction 	MONDO:0005068	myocardial infarction	up-regulated	RT-qPCR	"circ_0097682 is up-regulated in I/R-induced human cardiomyocyte injury and promotes injury-related phenotypes, including reduced proliferation, increased apoptosis, inflammation, and oxidative stress. Salidroside suppresses circ_0097682, thereby relieving inhibition of miR-671-5p and reducing USP46 expression through the circ_0097682/miR-671-5p/USP46 pathway."	0.7626
37740794	Archives of gynecology and obstetrics	2023	Circular RNA as new serum metabolic biomarkers in patients with premature ovarian insufficiency.		hsa_circRNA_008901 			premature ovarian insufficiency 	MONDO:0005387	primary ovarian failure	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_008901 was significantly downregulated in plasma from POI patients and showed diagnostic potential with an AUC of 0.8445. Bioinformatics analysis suggested it may act as a miRNA sponge for five predicted miRNAs and may influence PI3K-AKT-related pathways, follicle development, granulosa cell proliferation/differentiation, inflammation, and glucose metabolism."	0.5047
37740794	Archives of gynecology and obstetrics	2023	Circular RNA as new serum metabolic biomarkers in patients with premature ovarian insufficiency.		hsa_circRNA_403959 			premature ovarian insufficiency 	MONDO:0005387	primary ovarian failure	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_403959 was significantly downregulated in plasma from POI patients and showed diagnostic potential with an AUC of 0.8041. Bioinformatics analysis suggested it may act as a miRNA sponge for five predicted miRNAs and may influence PI3K-AKT-related pathways, follicle development, granulosa cell proliferation/differentiation, inflammation, and glucose metabolism."	0.5047
37740818	Molecular biotechnology	2024	Circ_103809 Aggravates the Malignant Phenotype of Pancreatic Cancer Through Modulating miR-197-3p/TSPAN3 Axis.	hsa_circ_0072088	circ_103809 	hsa_circ_ZFR	ZFR	pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; Microarray	"circ_103809 is up-regulated in pancreatic cancer tissues and cell lines and functions as a promoter of malignant phenotypes. Mechanistically, it directly binds miR-197-3p and upregulates TSPAN3, thereby enhancing PC cell proliferation, colony formation, migration, invasion, and metastasis-related behavior. The study proposes the circ_103809/miR-197-3p/TSPAN3 axis as a potential biomarker and therapeutic target for PC."	0.6815
37743442	Journal of bioenergetics and biomembranes	2023	"Hsa_circ_0052611 and mir-767-5p guide the warburg effect, migration, and invasion of BRCA cells through modulating SCAI."	hsa_circ_0052611	circ_0052611	hsa_circ_NOL10	NOL10	breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0052611/circ_0052611 is a NOL10-derived human circRNA downregulated in BRCA tissues and cells. It functions as a tumor-suppressive circRNA by sponging miR-767-5p to upregulate SCAI, thereby inhibiting Warburg Effect-related glycolysis, migration, invasion, EMT-associated marker changes, and xenograft tumor growth while promoting apoptosis. The study proposes the circ_0052611/miR-767-5p/SCAI ceRNA axis as a potential biomarker and therapeutic target for BRCA."	0.8396
37747673	Molecular biotechnology	2024	CircCCL22 Regulates CDC25A via Sponging miR-543 and Promotes Proliferation and Metastasis in Endometrial Cancer.	hsa_circ_0039569	circCCL22 	hsa_circ_CCL22	CCL22	Endometrial cancer 	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR	"circCCL22 is up-regulated in endometrial cancer tissues and cells and is associated with aggressive clinicopathological features. It promotes EC proliferation, migration, invasion, EMT-related changes, and xenograft tumor growth by acting as a sponge for miR-543 and regulating CDC25A expression, suggesting a potential therapeutic target role."	0.8005
37748540	Cellular signalling	2023	Hsa_circ_0046534 accelerates esophageal squamous cell carcinoma proliferation and metastasis via regulating MMP2 expression by sponging miR-339-5p.	hsa_circ_0046534	circ_0046534 	hsa_circ_TBCD	TBCD	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0046534 is up-regulated in ESCC tissues and cells and functions as an oncogenic circRNA. It promotes ESCC proliferation, migration, invasion, tumour growth and metastasis by sponging miR-339-5p and increasing MMP2 expression through the circ_0046534/miR-339-5p/MMP2 regulatory axis. The study suggests that circ_0046534 may serve as a biomarker and therapeutic target for ESCC."	0.8005
37750014	Experimental dermatology	2023	Analysis of circRNA profiles and clinical value in Stevens-Johnson syndrome and toxic epidermal necrolysis.	hsa_circ_0000711				Stevens-Johnson syndrome 	MONDO:0018229	Stevens-Johnson syndrome	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000711 was significantly down-regulated in PBMCs from SJS/TEN patients and validated by qPCR. Its expression was not significantly correlated with epidermal detachment area or SCORTEN score, and no circRNA-specific mechanistic axis was experimentally confirmed."	0.4032
37750014	Experimental dermatology	2023	Analysis of circRNA profiles and clinical value in Stevens-Johnson syndrome and toxic epidermal necrolysis.	hsa_circ_0083619				Stevens-Johnson syndrome 	MONDO:0018229	Stevens-Johnson syndrome	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0083619 was significantly down-regulated in PBMCs from SJS/TEN patients and validated by qPCR. Its lower expression correlated with greater disease severity, including SCORTEN score and epidermal detachment area, and the authors proposed a predicted hsa_circ_0083619/miR-18a-5p/BCL2L10 ceRNA axis in SJS/TEN pathogenesis."	0.4032
37750014	Experimental dermatology	2023	Analysis of circRNA profiles and clinical value in Stevens-Johnson syndrome and toxic epidermal necrolysis.	hsa_circ_0005615				Stevens-Johnson syndrome 	MONDO:0018229	Stevens-Johnson syndrome	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005615 was significantly down-regulated in PBMCs from SJS/TEN patients and validated by qPCR. Its expression was not significantly correlated with epidermal detachment area or SCORTEN score, and no circRNA-specific mechanistic axis was experimentally confirmed."	0.4032
37750014	Experimental dermatology	2023	Analysis of circRNA profiles and clinical value in Stevens-Johnson syndrome and toxic epidermal necrolysis.	hsa_circ_0003028				Stevens-Johnson syndrome 	MONDO:0018229	Stevens-Johnson syndrome	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0003028 was significantly up-regulated in PBMCs from SJS/TEN patients and validated by qPCR. Its expression was not significantly correlated with epidermal detachment area or SCORTEN score, and no circRNA-specific mechanistic axis was experimentally confirmed."	0.4032
37750590	Molecular carcinogenesis	2024	Comprehensive evaluation of serum circHAS2 as a novel diagnostic and prognostic biomarker for gastric cancer.		circHAS2	hsa_circ_HAS2	HAS2	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"This study identifies serum circHAS2 as an upregulated circRNA biomarker in gastric cancer. Its serum expression distinguishes GC and early GC from controls, correlates with malignancy-related clinicopathological parameters, decreases after surgery and chemotherapy, and high expression is associated with worse survival."	0.5918
37750597	Molecular carcinogenesis	2024	circPPP2R4 promotes colorectal cancer progression and reduces ROS production through the miR-646/FOXK1 axis.	hsa_circ_0089033	circPPP2R4	hsa_circ_PPP2R4	PPP2R4	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circPPP2R4 is upregulated in colorectal cancer tissues and cells and is associated with advanced clinical stage, T stage and lymph node metastasis. It promotes CRC proliferation, migration, invasion, tumor growth and lung metastasis by acting as a miR-646 sponge to upregulate FOXK1 and reduce ROS production. The study suggests circPPP2R4 has potential diagnostic and therapeutic value in CRC."	0.8933
37757976	Genomics	2023	hsa_circ_0005991 promotes epithelial-mesenchymal transition by regulating miR-30b-3p/Cdc42EP1 axis in ovary endometriosis.	hsa_circ_0005991				ovarian endometriosis 	MONDO:0006337	ovarian endometriosis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005991 is up-regulated in ectopic endometrium from ovarian endometriosis patients and is higher in severe disease than mild disease. It promotes proliferation, migration, invasion, and EMT in Ishikawa cells by acting as a ceRNA for miR-30b-3p, leading to increased Cdc42EP1 expression."	0.7893
37757976	Genomics	2023	hsa_circ_0005991 promotes epithelial-mesenchymal transition by regulating miR-30b-3p/Cdc42EP1 axis in ovary endometriosis.	hsa_circ_0006919				ovarian endometriosis 	MONDO:0006337	ovarian endometriosis	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0006919 was selected from the differentially expressed circRNA-miRNA network and was validated by RT-qPCR as significantly overexpressed in ectopic endometrium compared with matched eutopic endometrium. The study did not perform functional assays specifically for this circRNA.	0.4032
37757976	Genomics	2023	hsa_circ_0005991 promotes epithelial-mesenchymal transition by regulating miR-30b-3p/Cdc42EP1 axis in ovary endometriosis.	hsa_circ_0008016				ovarian endometriosis 	MONDO:0006337	ovarian endometriosis	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0008016 was selected from the differentially expressed circRNA-miRNA network and was validated by RT-qPCR as significantly overexpressed in ectopic endometrium compared with matched eutopic endometrium. The study did not perform functional assays specifically for this circRNA.	0.4032
37757976	Genomics	2023	hsa_circ_0005991 promotes epithelial-mesenchymal transition by regulating miR-30b-3p/Cdc42EP1 axis in ovary endometriosis.	hsa_circ_0007444				ovarian endometriosis 	MONDO:0006337	ovarian endometriosis	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0007444 was selected from the differentially expressed circRNA-miRNA network and was validated by RT-qPCR as significantly overexpressed in ectopic endometrium compared with matched eutopic endometrium. The study did not perform functional assays specifically for this circRNA.	0.4032
37757976	Genomics	2023	hsa_circ_0005991 promotes epithelial-mesenchymal transition by regulating miR-30b-3p/Cdc42EP1 axis in ovary endometriosis.	hsa_circ_0086414				ovarian endometriosis 	MONDO:0006337	ovarian endometriosis	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0086414 was selected from the differentially expressed circRNA-miRNA network and was validated by RT-qPCR as significantly overexpressed in ectopic endometrium compared with matched eutopic endometrium. The study did not perform functional assays specifically for this circRNA.	0.4032
37758970	Molecular biotechnology	2024	Circ-KATNAL1 Knockdown Reduces Neuronal Apoptosis and Alleviates Spinal Cord Injury Through the miR-98-5p/PRDM5 Regulatory Axis.		circ-KATNAL1	rno_circ_KATNAL1	KATNAL1	Spinal cord injury 	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR	"circ-KATNAL1 is up-regulated in spinal cord tissue after SCI in rats. Its knockdown improves neurological function, reduces spinal cord pathological injury, and suppresses neuronal apoptosis and inflammatory responses, at least partly through the miR-98-5p/PRDM5 regulatory axis."	0.5627
37769807	Life sciences	2023	Circ_0114581 promotes osteogenic differentiation of BMSCs via the MiR-155-5p/HNRNPA3 axis.	hsa_circ_0114581	Circ_0114581 	hsa_circ_DPYD	DPYD	Osteoporosis 	MONDO:0005298	osteoporosis	dysregulated	RT-qPCR; Microarray	"This study identified hsa_circ_0114581 as an OP-related circRNA that promotes osteogenic differentiation and BMSC viability. Mechanistically, hsa_circ_0114581 functions as a ceRNA by sponging hsa-miR-155-5p, thereby upregulating HNRNPA3 and supporting bone formation. The hsa_circ_0114581/miR-155-5p/HNRNPA3 axis is proposed as a potential biomarker and therapeutic target in osteoporosis."	0.8095
37770418	Chemical biology & drug design	2024	Sevoflurane inhibits oral squamous carcinoma progression by modulating the circ_0000857/miR-145-5p axis.	hsa_circ_0000857		hsa_circ_ZNF236	ZNF236	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circ_0000857 is highly expressed in OSCC tissues and is mainly cytoplasmic. Silencing circ_0000857 suppresses OSCC cell migration, invasion, and angiogenesis, while sevoflurane reduces circ_0000857 expression and inhibits OSCC progression through the circ_0000857/miR-145-5p axis involving MMP2, MMP9, and VEGFA."	0.8275
37775001	Environmental research	2023	Adipocyte-derived exosomes promote the progression of triple-negative breast cancer through circCRIM1-dependent OGA activation.		circCRIM1 	hsa_circ_CRIM1	CRIM1	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; RNA-seq	"Adipocyte-derived exosomal circCRIM1 is up-regulated in TNBC patients with high body fat percentage and is associated with poorer survival. It promotes TNBC proliferation, tumor growth, invasion and metastasis by sponging miR-503-5p, activating OGA, and suppressing FBP1 via reduced protein stability and increased ubiquitination. The study suggests exo-circCRIM1 as a potential diagnostic biomarker and therapeutic target for obese TNBC patients."	0.8319
37776372	Functional & integrative genomics	2023	Circular RNA eukaryotic translation initiation factor 6 facilitates TPC-1 cell proliferation and invasion through the microRNA-138-5p/lipase H axis.		circular RNA eukaryotic translation initiation factor 6 	hsa_circ_EIF6	EIF6	thyroid cancer 	MONDO:0002108	thyroid cancer	up-regulated	RT-qPCR	"circEIF6 is up-regulated in thyroid cancer tissues and cell lines and correlates with advanced clinicopathological features including TNM stage, lymph node metastasis, and tumor size. Functionally, circEIF6 promotes TPC-1 cell proliferation, invasion, EMT-related marker changes, and xenograft tumor growth. Mechanistically, circEIF6 acts as a ceRNA that sponges miR-138-5p to increase LIPH expression."	0.8158
37778995	International heart journal	2023	Exosomes Promote Atherosclerosis Progression by Regulating Circ_100696/miR-503-5p/PAPPA Axis-Mediated Vascular Smooth Muscle Cells Proliferation and Migration.	hsa_circ_0008896	circ_100696			atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR; Microarray	"This study identifies ox-LDL-induced THP-1 macrophage-derived exosomal circ_100696 as an up-regulated circRNA in an in vitro atherosclerosis model. Circ_100696 promotes VSMC proliferation, cell cycle progression, and migration by sponging miR-503-5p and increasing PAPPA expression, thereby contributing to AS progression."	0.6578
37786235	Clinical and experimental pharmacology & physiology	2023	Circ_0026579 knockdown ameliorates lipopolysaccharide-induced human lung fibroblast cell injury by regulating CXCR1 via miR-370-3p.	hsa_circ_0026579	circ_0026579	hsa_circ_ESPL1	ESPL1	pneumonia 	MONDO:0005249	pneumonia	up-regulated	RT-qPCR	"circ_0026579 is upregulated in serum from pediatric pneumonia patients and in LPS-induced MRC-5 human lung fibroblast cells. It promotes inflammatory response, oxidative stress and apoptosis while suppressing proliferation through a ceRNA mechanism involving miR-370-3p and CXCR1; knockdown of circ_0026579 ameliorates LPS-induced cell injury."	0.8351
37787763	Carcinogenesis	2023	Construction and identification of lncRNA/circRNA-coregulated ceRNA networks in gemcitabine-resistant bladder carcinoma.	hsa_circ_0075881	circ_0075881			bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0075881 is up-regulated in gemcitabine-resistant T24 bladder cancer cells. It promotes gemcitabine resistance through a ceRNA mechanism involving miR-324-3p and ST6GAL1, increasing cell viability and reducing apoptosis under gemcitabine treatment."	0.6528
37787763	Carcinogenesis	2023	Construction and identification of lncRNA/circRNA-coregulated ceRNA networks in gemcitabine-resistant bladder carcinoma.	hsa_circ_0096069				bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0096069 is up-regulated in gemcitabine-resistant T24 bladder cancer cells. It was tested in the miR-324-3p-related ceRNA network, but its regulatory effects were reported as less consistent and no confirmed downstream functional axis was established."	0.3684
37787763	Carcinogenesis	2023	Construction and identification of lncRNA/circRNA-coregulated ceRNA networks in gemcitabine-resistant bladder carcinoma.	hsa_circ_0094679				bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0094679 is down-regulated in gemcitabine-resistant T24 bladder cancer cells. The paper positioned it as a potential component of the hsa_circ_0094679-miR-193a-5p-TP73 ceRNA pathway, but did not perform functional validation because suitable siRNAs were not available."	0.2465
37792549	Environmental toxicology	2024	Spleen tyrosine kinase facilitates the progression of papillary thyroid cancer regulated by the hsa_circ_0006417/miR-377-3p axis.	hsa_circ_0006417		hsa_circ_NEAT1	NEAT1	papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0006417 is upregulated in papillary thyroid cancer tissues and cells. It acts as a tumor-promoting ceRNA by sponging miR-377-3p, thereby increasing SYK expression and activating the mTOR/4E-BP1 signaling pathway to promote PTC cell proliferation, migration, and invasion."	0.8115
37793583	Clinical biochemistry	2023	A circRNA-based ceRNA network shows its diagnostic value in non-small-cell lung cancer.	hsa_circ_0061235	circ_0061235	hsa_circ_TPTE	TPTE	non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"This study identified serum circ_0061235 as a downregulated circRNA in NSCLC and established a circ_0061235-miR-3180-5p-PPM1L ceRNA network. The axis has diagnostic value for distinguishing NSCLC from healthy controls and benign lung tumors, and low circ_0061235 levels are associated with more aggressive NSCLC features including lymph node metastasis, distant metastasis, and advanced stage."	0.459
37798872	Journal of genetics	2023	Serum exosomal hsa_circRNA_0001842 is the potential biomarker for diagnosing lower limb vascular disease in type 2 diabetes mellitus.	hsa_circ_0085428				lower limb vascular disease 	MONDO:0005385	vascular disorder	up-regulated	RT-qPCR; Microarray	Serum exosomal hsa_circ_0085428 was up-regulated in T2DM patients with LLVD and was evaluated by ROC analysis as a possible predictor of lower extremity vascular disease. The study did not investigate its molecular mechanism.	0.5662
37798872	Journal of genetics	2023	Serum exosomal hsa_circRNA_0001842 is the potential biomarker for diagnosing lower limb vascular disease in type 2 diabetes mellitus.	hsa_circ_0001842	hsa_circRNA_0001842 	hsa_circ_Smu1	Smu1	lower limb vascular disease 	MONDO:0005385	vascular disorder	up-regulated	RT-qPCR; Microarray	"Serum exosomal hsa_circ_0001842 was up-regulated in T2DM patients with LLVD and showed the strongest diagnostic performance among the validated candidate circRNAs. It was proposed as a potential biomarker for identifying lower extremity vascular disease in T2DM patients, while its pathogenic mechanism remains unelucidated."	0.5662
37798872	Journal of genetics	2023	Serum exosomal hsa_circRNA_0001842 is the potential biomarker for diagnosing lower limb vascular disease in type 2 diabetes mellitus.	hsa_circ_0073470				lower limb vascular disease 	MONDO:0005385	vascular disorder	down-regulated	RT-qPCR; Microarray	Serum exosomal hsa_circ_0073470 was identified as a down-regulated candidate circRNA in T2DM patients with LLVD and was evaluated by ROC analysis as a potential predictor. The study did not characterize its molecular mechanism.	0.5662
37801226	Tissue engineering and regenerative medicine	2023	circ_SPEF2 Regulates the Balance of Treg Cells by Regulating miR-16-5p/BACH2 in Lymphoma and Participates in the Immune Response.	hsa_circ_0128899		hsa_circ_SPEF2	SPEF2	diffuse large B-cell lymphoma 	MONDO:0018905	diffuse large B-cell lymphoma	down-regulated	RT-qPCR	"circSPEF2 is down-regulated in DLBCL tissues and cell lines. Its overexpression suppresses lymphoma cell proliferation and tumor growth, promotes apoptosis, increases CD4 T-cell proportion, and reduces Treg-cell proportion. Mechanistically, circSPEF2 acts through the miR-16-5p/BACH2 axis and may serve as a potential therapeutic target for DLBCL."	0.8442
37802173	Cellular signalling	2023	CircRNA0007766 accelerates cancer progression via miR-34c-5p/cyclin D1 axis in adenocarcinoma of the esophagogastric junction (AEG).	hsa_circ_0007766 		hsa_circ_ERBB2	ERBB2	adenocarcinoma of the esophagogastric junction 	MONDO:0003219	gastroesophageal junction adenocarcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circRNA0007766 is a human ERBB2-derived circRNA that is significantly upregulated in AEG tissues and cell lines. It promotes AEG proliferation, migration, invasion, tumorigenesis, cell cycle progression and EMT-related changes while reducing apoptosis, mainly through a ceRNA mechanism in which it sponges miR-34c-5p to upregulate cyclin D1. Clinically, high circRNA0007766 expression is associated with lymph node metastasis, poor prognosis and shorter overall survival, suggesting diagnostic and prognostic biomarker potential."	0.8648
37802826	Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica	2023	[Cangxi Tongbi Capsules promote chondrocyte autophagy by regulating circRNA£ß0008365/miR-1271/p38 MAPK pathway to inhibit development of knee osteoarthritis].	hsa_circ_0008365				knee osteoarthritis 	MONDO:0005416	"osteoarthritis, knee"	down-regulated	RT-qPCR	"circRNA_0008365 is down-regulated in KOA/IL-1beta-treated chondrocytes and appears to act as a protective circRNA. Cangxi Tongbi Capsules increase circRNA_0008365 expression, suppress the miR-1271/p38 MAPK pathway, promote chondrocyte autophagy, reduce apoptosis and extracellular matrix catabolism, and thereby inhibit KOA progression."	0.4236
37803896	Biomedical and environmental sciences : BES	2023	Characterization of CircRNA-Associated CeRNA Networks in Folate Deficiency-Induced Neural Tube Defects.		Circzfp644 	mmu_circ_zfp644	zfp644	neural tube defects 	MONDO:0008449	spina bifida	down-regulated	RT-qPCR; RNA-seq	"Circzfp644 was identified as a significantly downregulated circRNA in low-folate/MTX-induced mouse NTD brain tissue and in human NTD fetal brain samples. The study supports a Circzfp644-miR-20-5p-Gas7 ceRNA axis in which Circzfp644 sponges miR-20-5p to relieve repression of Gas7, linking reduced Circzfp644 to NTD pathogenesis under low-folate conditions."	0.7689
37811627	Discovery medicine	2023	"Transcriptome Sequencing of lncRNAs, circRNAs, miRNAs, mRNAs, and Interaction Network Constructing in Acute Exacerbation of Idiopathic Pulmonary Fibrosis."	hsa_circ_0053515				acute exacerbation of idiopathic pulmonary fibrosis 	MONDO:0800504	idiopathic pulmonary fibrosis	up-regulated	RNA-seq	"This circRNA was identified as part of a pivotal ceRNA pair, hsa-circ-0053515/hsa-miR-150-5p/E2F3, in IPF patients with lung heat and collateral stasis (LHCS). The study suggests it may contribute to LHCS progression through a ceRNA network involving hsa-miR-150-5p and E2F3, but experimental validation is lacking."	0.1768
37812360	Cell biology and toxicology	2023	circSSPO boosts growth of esophageal squamous cell carcinoma through upregulation of micrRNA-6820-5p-mediated KLK8 and PKD1 expression.	hsa_circ_0082878	circSSPO 	hsa_circ_SSPO	SSPO	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circSSPO is an up-regulated oncogenic circRNA in ESCC. It acts as a ceRNA for miR-6820-5p, increasing KLK8 and PKD1 expression and thereby promoting malignant ESCC cell behaviors, tumor growth, and metastasis. Higher circSSPO expression is associated with shorter overall survival."	0.8961
37812578	Journal of cellular physiology	2023	CircANKRD17 promotes glycolysis by inhibiting miR-143 in breast cancer cells.	hsa_circ_0001417	circ ankyrin repeat domain 17	hsa_circ_ANKRD17	ANKRD17	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; ISH	"circANKRD17 is up-regulated in breast cancer cells and promotes glycolysis and malignant phenotypes including proliferation, migration, invasion, and cell-cycle progression. Mechanistically, circANKRD17 acts as a cytoplasmic sponge for miR-143, relieving repression of HK2 and increasing glycolytic activity, including glucose consumption, lactate production, and 18 F-FDG uptake. In patient BC tissues, high circANKRD17 expression is associated with higher SUV max on 18 F-FDG PET/CT, supporting its potential as a therapeutic target for cancerous glycolysis."	0.8793
37813099	Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme	2023	CircPI4KA Overexpression Enhances Carcinogenesis and Glycolysis Metabolism in Papillary Thyroid Carcinoma by Causing the miR-1287-5p-Mediated NRP2 Expression Elevation.	hsa_circ_0062389	circPI4KA	hsa_circ_PI4KA	PI4KA	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circPI4KA is overexpressed in PTC tissues and cell lines and functions as a pro-cancer circRNA. It promotes PTC cell proliferation, migration, invasion, glycolysis and in vivo tumor growth while suppressing apoptosis, mainly through sponging miR-1287-5p to increase NRP2 expression. Clinically, its expression is associated with TNM stage and lymph node metastasis."	0.8443
37814151	Cell biochemistry and biophysics	2024	Circular RNA circ-SLC7A5 Functions as a Competing Endogenous RNA to Impact Cell Biological Behaviors in Esophageal Squamous Cell Carcinoma (ESCC).	hsa_circ_0040796	circRNA solute carrier family 7 member 5 	hsa_circ_SLC7A5	SLC7A5	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"circ-SLC7A5/hsa_circ_0040796 is up-regulated in human ESCC tissues and cell lines. It promotes ESCC cell growth, cell cycle progression, migration, invasion and xenograft tumor growth while suppressing apoptosis. Mechanistically, it acts as a ceRNA for miR-874-3p to up-regulate CORO1C."	0.8572
37815551	Experimental brain research	2023	Circ_0059662 exerts a positive role in oxygen-glucose deprivation/reoxygenation-induced SK-N-SH cell injury.	hsa_circ_0059662	circ_0059662			ischemic stroke 	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; Microarray	"This study identified circ_0059662 as an up-regulated circRNA in AIS patients and OGD/R-induced SK-N-SH ischemic stroke cell models. Functionally, circ_0059662 promotes OGD/R-induced cell injury by inhibiting proliferation and enhancing apoptosis, inflammation and oxidative stress. Mechanistically, circ_0059662 sponges miR-579-3p to positively regulate ETS1 expression, suggesting the circ_0059662/miR-579-3p/ETS1 axis as a potential therapeutic target for ischemic stroke."	0.8002
37815624	Applied biochemistry and biotechnology	2024	Hsa_circ_0054220 Upregulates HMGA1 by the Competitive RNA Pattern to Promote Neural Impairment in MPTP Model of Parkinson's Disease.	hsa_circ_0054220	Circ_0054220	hsa_circ_LOC728730	LOC728730	Parkinson's disease 	MONDO:0005180	Parkinson disease	up-regulated	RT-qPCR; ISH	"hsa_circ_0054220 is up-regulated in PD-related models and in a PD patient dataset. It promotes neural impairment by acting as a ceRNA that sponges miR-145 and miR-625, leading to increased HMGA1 expression, reduced SH-SY5Y cell viability, and enhanced apoptosis."	0.8058
37817544	Journal of dental research	2023	Circ-Slain2 Alleviates Cartilage Degradation and Inflammation of TMJOA.		circ-slain2	mmu_circ_slain2	slain2	temporomandibular joint osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR; RNA-seq	"circ-slain2 is downregulated in TMJOA cartilage and inflammatory cytokine-treated mouse condylar chondrocytes. Its overexpression alleviates cartilage degradation and synovial inflammation, likely by interacting with ATF6 and suppressing ER stress."	0.7519
37817544	Journal of dental research	2023	Circ-Slain2 Alleviates Cartilage Degradation and Inflammation of TMJOA.		circ-pik3r1	mmu_circ_pik3r1	pik3r1	temporomandibular joint osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR; RNA-seq	circ-pik3r1 was identified by RNA-seq as a differentially expressed circRNA and validated by qRT-PCR as downregulated in IFNgamma/TNFalpha-treated mouse condylar chondrocytes. The study did not report mechanistic or functional assays specifically for circ-pik3r1.	0.3213
37817544	Journal of dental research	2023	Circ-Slain2 Alleviates Cartilage Degradation and Inflammation of TMJOA.		circ-serpine2	mmu_circ_serpine2	serpine2	temporomandibular joint osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR; RNA-seq	circ-serpine2 was identified by RNA-seq as a differentially expressed circRNA and validated by qRT-PCR as downregulated in IFNgamma/TNFalpha-treated mouse condylar chondrocytes. The study did not report mechanistic or functional assays specifically for circ-serpine2.	0.3213
37818058	American journal of cancer research	2023	Expression of plasma exosomal circLPAR1 in patients with gastric cancer and its clinical application value.	hsa_circ_0087960	circLPAR1 	hsa_circ_LPAR1	LPAR1	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"This study shows that circLPAR1/hsa_circ_0087960 is down-regulated in gastric cancer tissues and plasma exosomes. Plasma exosomal circLPAR1 has diagnostic value, correlates with clinicopathological progression features, increases after surgery, and high expression is associated with better survival. The work supports circLPAR1 as a non-invasive exosomal biomarker for GC diagnosis and prognosis, but does not experimentally define its molecular mechanism."	0.4992
37818060	American journal of cancer research	2023	Integrative analysis of circular RNA regulatory network in papillary thyroid carcinoma.	hsa_circ_0092299				papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0092299 is significantly up-regulated in PTC tissues and was prioritized as a key circRNA in a predicted circRNA-miRNA-mRNA network. It may regulate PTC progression through interactions with miR-486, miR-574, miR-665 and hub genes such as BBC3, E2F1, FYN, SDC1, SDC3, SNAP25, TK1 and TYMS."	0.5963
37818060	American journal of cancer research	2023	Integrative analysis of circular RNA regulatory network in papillary thyroid carcinoma.	hsa_circ_0041829				papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circ_0041829 is significantly up-regulated in PTC tissues and was highlighted as one of two major circRNAs in the study. It is predicted to participate in a circRNA-miRNA-mRNA regulatory network through hsa-miR-369-5p and hub genes associated with PTC progression.	0.5963
37818060	American journal of cancer research	2023	Integrative analysis of circular RNA regulatory network in papillary thyroid carcinoma.	hsa_circ_0011385	circ_0011385			papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circ_0011385 was identified as an up-regulated differentially expressed circRNA in PTC and validated by qRT-PCR. It is predicted to interact with hsa-miR-361-3p and hsa-miR-1272 in a potential ceRNA regulatory network.	0.5135
37818060	American journal of cancer research	2023	Integrative analysis of circular RNA regulatory network in papillary thyroid carcinoma.	hsa_circ_0044556				papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circ_0044556 was newly identified as an up-regulated circRNA in PTC and validated by qRT-PCR. It is predicted to interact with hsa-miR-589-5p and hsa-miR-634 in a potential ceRNA network.	0.5135
37818060	American journal of cancer research	2023	Integrative analysis of circular RNA regulatory network in papillary thyroid carcinoma.	hsa_circ_0048937				papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0048937 was newly identified and validated as up-regulated in PTC. It is predicted to interact with several miRNAs, especially miR-624, miR-643 and miR-665, and may have a significant role in THCA through a circRNA-miRNA-hub gene network."	0.5963
37818060	American journal of cancer research	2023	Integrative analysis of circular RNA regulatory network in papillary thyroid carcinoma.	hsa_circ_0092278				papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0092278 was newly identified and validated as an up-regulated circRNA in PTC. It is predicted to interact with five miRNAs, including hsa-miR-502-5p, within a potential ceRNA network."	0.5135
37818060	American journal of cancer research	2023	Integrative analysis of circular RNA regulatory network in papillary thyroid carcinoma.	hsa_circ_0079891	circ_0079891			papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0079891 is down-regulated in PTC tissues and was validated by qRT-PCR. It is predicted to interact with multiple miRNAs, including hsa-miR-361-3p and hsa-miR-182-5p, suggesting involvement in PTC-related ceRNA regulation."	0.5135
37818060	American journal of cancer research	2023	Integrative analysis of circular RNA regulatory network in papillary thyroid carcinoma.	hsa_circ_0005777	circ_0005777			papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR; Microarray	hsa_circ_0005777 is down-regulated in PTC tissues and validated by qRT-PCR. It is predicted to interact with hsa-miR-607 and hsa-miR-1225-5p in a potential PTC ceRNA network.	0.5135
37818060	American journal of cancer research	2023	Integrative analysis of circular RNA regulatory network in papillary thyroid carcinoma.	hsa_circ_0021549				papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0021549 is down-regulated in PTC tissues and validated by qRT-PCR. It is predicted to interact with four miRNAs, including hsa-miR-574-5p, within a potential circRNA-miRNA-mRNA network."	0.5135
37818060	American journal of cancer research	2023	Integrative analysis of circular RNA regulatory network in papillary thyroid carcinoma.	hsa_circ_0000253	circ_0000253			papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR; Microarray	hsa_circ_0000253 was newly identified and validated as down-regulated in PTC. It is predicted to interact with hsa-miR-1236-3p and hsa-miR-1324 in a potential ceRNA regulatory network.	0.5135
37818060	American journal of cancer research	2023	Integrative analysis of circular RNA regulatory network in papillary thyroid carcinoma.	hsa_circ_0076092				papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR; Microarray	hsa_circ_0076092 was newly identified and validated as down-regulated in PTC. It is predicted to interact with hsa-miR-1206 and hsa-miR-643 within a potential ceRNA network.	0.5135
37818060	American journal of cancer research	2023	Integrative analysis of circular RNA regulatory network in papillary thyroid carcinoma.	hsa_circ_0021553				papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0021553 was newly identified and validated as down-regulated in PTC. It is predicted to interact with hsa-miR-1257, hsa-miR-548p, hsa-miR-574-5p and hsa-miR-661 in a potential ceRNA network."	0.5135
37820700	Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme	2023	Hsa_circ_0080608 Attenuates Lung Cancer Progression by Functioning as a Competitive Endogenous RNA to Regulate the miR-661/ADRA1A Pathway.	hsa_circ_0080608	circ_0080608	hsa_circ_GTF2I	GTF2I	lung cancer 	MONDO:0008903	lung cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0080608/circ_0080608 is down-regulated in lung cancer tissues and cells. Its overexpression suppresses lung cancer cell proliferation, colony formation, migration, and xenograft tumor growth. Mechanistically, circ_0080608 acts as a ceRNA for miR-661 and regulates the miR-661/ADRA1A axis to exert anticancer effects."	0.7893
37822112	Autoimmunity	2023	Circ_0035796 depletion inhibits transforming growth factor-beta1-induced pulmonary fibrosis in a miR-150-5p/L1CAM-dependent manner.	hsa_circ_0035796	circ_0035796			pulmonary fibrosis 	MONDO:0002771	pulmonary fibrosis	up-regulated	RT-qPCR	"circ_0035796 is up-regulated in TGF-beta1-treated human HFL1 fibroblasts and promotes pulmonary fibrosis-related fibroblast activation. Its knockdown suppresses proliferation, migration, invasion, ECM marker expression, inflammatory cytokine production and oxidative stress by acting through the miR-150-5p/L1CAM axis, suggesting potential therapeutic relevance."	0.7451
37822284	Journal of biochemical and molecular toxicology	2024	CircDLGAP4 overexpression ameliorates neuronal injury in Parkinson's disease by binding to EIF4A3 and increasing HMGA2 expression.		circRNA DLGassociated protein 4 	hsa_circ_DLGAP4	DLGAP4	Parkinson's disease 	MONDO:0005180	Parkinson disease	down-regulated	RT-qPCR	"circDLGAP4 is down-regulated in MPP + -induced Parkinson's disease cell models. Its overexpression protects against neuronal injury by increasing cell activity, suppressing apoptosis, inflammation, and oxidative stress. Mechanistically, circDLGAP4 binds/recruits EIF4A3 to enhance HMGA2 mRNA stability and upregulate HMGA2 expression."	0.7394
37822284	Journal of biochemical and molecular toxicology	2024	CircDLGAP4 overexpression ameliorates neuronal injury in Parkinson's disease by binding to EIF4A3 and increasing HMGA2 expression.		circRNA DLGassociated protein 4 	 mmu_circ_DLGAP4	DLGAP4	Parkinson's disease 	MONDO:0005180	Parkinson disease	down-regulated	RT-qPCR	"circDLGAP4 is down-regulated in MPP + -induced Parkinson's disease cell models. Its overexpression protects against neuronal injury by increasing cell activity, suppressing apoptosis, inflammation, and oxidative stress. Mechanistically, circDLGAP4 binds/recruits EIF4A3 to enhance HMGA2 mRNA stability and upregulate HMGA2 expression."	0.7394
37827345	Cellular signalling	2023	CircUBR1 knockdown relieves ventilator-induced lung injury through regulating miR-20a-5p/GGPPS1 pathway.		circUBR1	hsa_circ_UBR1	UBR1	ventilator-induced lung injury 	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR; Microarray	"circUBR1 is up-regulated in VILI mouse lung tissues and BALF, CS-treated alveolar epithelial cells, and BALF from mechanically ventilated ARDS patients. Functionally, circUBR1 knockdown protects against VILI by improving cell viability and reducing lung injury, epithelial cell apoptosis and inflammatory cytokine production. Mechanistically, circUBR1 sponges miR-20a-5p to regulate GGPPS1, forming a circUBR1/miR-20a-5p/GGPPS1 pathway."	0.7132
37827345	Cellular signalling	2023	CircUBR1 knockdown relieves ventilator-induced lung injury through regulating miR-20a-5p/GGPPS1 pathway.		circUBR1	mmu_circ_UBR1	UBR1	ventilator-induced lung injury 	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR; Microarray	"circUBR1 is up-regulated in VILI mouse lung tissues and BALF, CS-treated alveolar epithelial cells, and BALF from mechanically ventilated ARDS patients. Functionally, circUBR1 knockdown protects against VILI by improving cell viability and reducing lung injury, epithelial cell apoptosis and inflammatory cytokine production. Mechanistically, circUBR1 sponges miR-20a-5p to regulate GGPPS1, forming a circUBR1/miR-20a-5p/GGPPS1 pathway."	0.7132
37832153	"Shock (Augusta, Ga.)"	2023	INTERFERING HSA_CIRC_0001226 MITIGATES LPS-INDUCED BEAS-2B CELL INJURY BY REGULATING MIR-940/TGFBR2 PATHWAY.	hsa_circ_0001226	circ_0001226	hsa_circ_MYH9	MYH9	Sepsis-associated acute lung injury 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR	"hsa_circ_0001226 is up-regulated in serum from SA-ALI patients and in LPS-induced BEAS-2B cells. It promotes SA-ALI-related cell injury by sponging miR-940 to up-regulate TGFBR2, thereby enhancing proliferation inhibition, apoptosis, and inflammatory cytokine production. Knockdown of circ_0001226 alleviates LPS-induced BEAS-2B dysfunction, suggesting potential diagnostic and therapeutic relevance."	0.7591
37843373	Journal of virology	2023	A novel protein encoded by circVPS13D attenuates antiviral innate immunity by targeting MAVS in teleost fish.		circVPS13D 		VPS13D	Siniperca chuatsi rhabdovirus infection 	MONDO:0024934	fish disease	up-regulated	RT-qPCR; RNA-seq	"circVPS13D is an SCRV-induced circRNA from the VPS13D gene in miiuy croaker. It encodes the peptide VPS13D-170aa, which binds MAVS and promotes K48-linked ubiquitination and proteasomal degradation of MAVS, thereby suppressing RLR/NF-kappaB/IRF3-mediated antiviral innate immunity and facilitating SCRV replication."	0.7884
37845343	Acta pharmacologica Sinica	2024	Hesperetin derivative 2a inhibits lipopolysaccharide-induced acute liver injury in mice via downregulation of circDcbld2.	mmu_circ_0000693	circDcbld2	mmu_circ_Dcbld2	Dcbld2	acute liver injury 	MONDO:0005359	drug-induced liver injury	up-regulated	RT-qPCR	"circDcbld2 is a mouse circRNA derived from Dcbld2 and is significantly upregulated in LPS-induced acute liver injury and LPS-treated RAW264.7 macrophages. Its knockdown alleviates liver inflammation and injury, while HD-2a suppresses circDcbld2 and reduces inflammatory injury through inhibition of the JAK2/STAT3 pathway."	0.73
37851953	Acta biochimica Polonica	2023	"Circular RNA AGFG1 motivates breast cancer cell proliferation, invasion, migration, and glycolysis by controlling microRNA-653-5p/14-3-3 protein epsilon."		circular RNA AGFG1 	hsa_circ_AGFG1	AGFG1	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circAGFG1 is up-regulated in breast cancer tissues and cell lines and its high expression is associated with aggressive clinicopathological features and poor overall survival. Functionally, circAGFG1 promotes proliferation, migration, invasion, glycolysis, and in vivo tumor growth while suppressing apoptosis. Mechanistically, it acts as a sponge for miR-653-5p to regulate YWHAE and downstream proteins including MMP9, GLUT1, and Bax."	0.8658
37851987	Acta biochimica Polonica	2023	Circular RNA sirtuin-1 restrains the malignant phenotype of non-small cell lung cancer cells via the microRNA-510-5p/SMAD family member 7 axis.		Circular RNA (circRNA) sirtuin-1 (SIRT1) 	hsa_circ_SIRT1	SIRT1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"CircSIRT1 is downregulated in NSCLC tissues and cell lines and is associated with TNM stage and tumor size. Functionally, circSIRT1 suppresses malignant NSCLC phenotypes including proliferation, invasion, migration and glycolysis while promoting apoptosis. Mechanistically, it acts through the miR-510-5p/SMAD7 axis to inhibit Wnt/beta-catenin signaling."	0.7591
37852428	Cancer letters	2023	Hypoxia-induced circ-CDYL-EEF1A2 transcriptional complex drives lung metastasis of cancer stem cells from hepatocellular carcinoma.		circ-CDYL 	hsa_circ_CDYL	CDYL	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"In HCC, circ-CDYL is up-regulated in ICAM-1+ CCSCs and liver CSCs and promotes lung metastasis. Mechanistically, hypoxia-induced HIF-1_ increases circ-CDYL through CDYL and EIF4A3, while nuclear circ-CDYL cooperates with EEF1A2 to activate COL14A1 transcription, leading to ERK signaling activation and EMT."	0.7663
37856945	Research in veterinary science	2023	Functional analysis of circSTX8 in chicken macrophages under lipopolysaccharide stimulation.		circular RNA STX8 	gga_circ_STX8	STX8	lipopolysaccharide (LPS) stimulation 	MONDO:0005113	bacterial infectious disease	down-regulated	RT-qPCR; RNA-seq	"In chicken macrophages and chicken lung under LPS stimulation, circSTX8 is significantly down-regulated. Functional experiments showed that circSTX8 overexpression worsens LPS-induced cellular injury by reducing macrophage viability and increasing pro-inflammatory cytokines. Bioinformatics analysis suggested a circSTX8-miRNA-mRNA regulatory network involving gga-miR-338-3p, gga-miR-1573, novel_122 and novel_185, with target genes enriched in immune and signaling pathways."	0.6631
37861952	Journal of molecular histology	2023	The circSNX14 functions as a tumor suppressor via the miR-562/ LATS2 pathway in hepatocellular carcinoma cells.		circSNX14 	hsa_circ_SNX14	SNX14	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"circSNX14 is down-regulated in HCC tissues and cell lines, and lower expression is associated with poorer overall survival and more aggressive clinicopathological features. Functionally, circSNX14 suppresses HCC cell proliferation, invasion, angiogenesis, EMT features, and xenograft tumor growth. Mechanistically, it sponges miR-562 and promotes LATS2 expression through the circSNX14/miR-562/LATS2 axis."	0.8769
37865306	Free radical biology & medicine	2023	"A novel circular RNA, circSQSTM1, protects the endothelial function in atherosclerosis."		circSQSTM1 	hsa_circ_SQSTM1	SQSTM1	atherosclerosis 	MONDO:0005311	atherosclerosis	unknown	RT-qPCR; Microarray	"circSQSTM1 is a human SQSTM1-derived circular RNA that exerts atheroprotective effects in endothelial cells. It upregulates Sirt1 by sponging miR-23b-3p and by interacting with eIF4A3 to promote FOXO1 mRNA nuclear export and FOXO1-mediated Sirt1 transcription, thereby suppressing inflammation and oxidative stress while promoting autophagy and reducing atherosclerotic progression in vivo."	0.8288
37866205	Advances in medical sciences	2023	Extracellular vesicle-derived circHIPK3: Novel diagnostic biomarker for lung cancer.		EVs-circHIPK3 	hsa_circ_HIPK3	HIPK3	lung cancer 	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; RNA-seq	"EV-derived circHIPK3 is significantly up-regulated in plasma extracellular vesicles from lung cancer patients and shows diagnostic potential with an AUC of 0.897. The study predicts that circHIPK3 may interact with miR-637 and potentially influence downstream TSPAN14-related processes, including migration-associated pathways, although the downstream mRNA axis requires further experimental exploration."	0.5047
37866664	Gene	2024	circ_SIRT1 upregulates ATG12 to facilitate Imatinib resistance in CML through interacting with EIF4A3.	hsa_circ_0018472	circ_SIRT1 	hsa_circ_SIRT1	SIRT1	chronic myeloid leukemia 	MONDO:0011996	"chronic myelogenous leukemia, BCR-ABL1 positive"	up-regulated	RT-qPCR	"circ_SIRT1 is a SIRT1-derived human circRNA that is up-regulated in CML, especially in Imatinib-resistant CML samples and K562/R cells. It promotes CML cell viability, invasion, autophagy, xenograft tumor growth and Imatinib resistance while suppressing apoptosis. Mechanistically, circ_SIRT1 binds EIF4A3 and increases ATG12 expression, linking the circ_SIRT1-EIF4A3-ATG12 mechanism to autophagy-associated Imatinib resistance."	0.8568
37867458	Journal of biochemical and molecular toxicology	2024	CircMETTL15 induces TMTC3 production by absorbing miR-944 to promote hepatocellular carcinoma cell malignancy.	hsa_circ_0000282	circMETTL15 	hsa_circ_METTL15	METTL15	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circMETTL15 is up-regulated in HCC tissues and HCC cell lines and is mainly localized in the cytoplasm. It promotes HCC cell proliferation, migration, invasion, angiogenic tube formation, and in vivo tumor growth by acting as a ceRNA that binds miR-944 and relieves repression of TMTC3. The study suggests circMETTL15 may serve as a therapeutic target or biomarker for HCC treatment."	0.8175
37870056	Protein and peptide letters	2023	Hsa_circ_0001687 Function as a ceRNA to Facilitate Hepatocellular Carcinoma Progression via miR-140- 3p/FOXQ1 Axis.	hsa_circ_0001687	circ_0001687	hsa_circ_MPP6	MPP6	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0001687 is up-regulated in HCC tissues and its high expression is associated with larger tumor size and poorer OS/RFS. Functionally, circ_0001687 promotes HCC cell proliferation and xenograft tumor growth. Mechanistically, cytoplasmic circ_0001687 functions as a ceRNA for miR-140-3p, thereby increasing FOXQ1 expression."	0.8548
37874674	Cell reports	2023	A circRNA therapy based on Rnf103 to inhibit Vibrio anguillarum infection.		circRnf103 		Rnf103	Vibrio anguillarum infection 	MONDO:0005583	non-human animal disease	unknown	RT-qPCR; RNA-seq	"circRnf103 is a Rnf103-derived circular RNA identified in teleost fish that encodes the 177-aa protein Rnf103-177aa. Rnf103-177aa competes with Rnf103 for Traf6 binding, blocks Traf6 ubiquitination and degradation, enhances innate immune signaling, and reduces V. anguillarum infection in cells and zebrafish."	0.8058
37874674	Cell reports	2023	A circRNA therapy based on Rnf103 to inhibit Vibrio anguillarum infection.		circRnf103 		Rnf103	Vibrio anguillarum infection 	MONDO:0005583	non-human animal disease	unknown	RT-qPCR; RNA-seq	"circRnf103 is a Rnf103-derived circular RNA identified in teleost fish that encodes the 177-aa protein Rnf103-177aa. Rnf103-177aa competes with Rnf103 for Traf6 binding, blocks Traf6 ubiquitination and degradation, enhances innate immune signaling, and reduces V. anguillarum infection in cells and zebrafish."	0.8058
37877530	Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti	2023	Circular RNA hsa-circ-0006203 - hsa-circ-0004872 as novel detecting biomarkers in oral cancer.	hsa_circ_0006203	hsa-circ-0006203 			oral cancer 	MONDO:0044925	oral cavity carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa-circ-0006203 was significantly downregulated in OSCC/oral cancer tissues compared with controls. The study suggests it may act as a tumor-suppressive circRNA and a potential diagnostic biomarker for OSCC, with expression correlated with pathological differentiation."	0.5261
37877530	Klinicka onkologie : casopis Ceske a Slovenske onkologicke spolecnosti	2023	Circular RNA hsa-circ-0006203 - hsa-circ-0004872 as novel detecting biomarkers in oral cancer.	hsa_circ_0004872	hsa-circ-0004872			oral cancer 	MONDO:0044925	oral cavity carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa-circ-0004872 was reported to be significantly downregulated in OSCC/oral cancer tissues. The study suggests it may be part of a regulatory circRNA network, may function as a tumor-suppressive circRNA, and may serve as a potential diagnostic biomarker for OSCC."	0.5261
37878047	Naunyn-Schmiedeberg's archives of pharmacology	2024	HuR-induced circ_0082319 contributes to hepatocellular carcinoma by elevating PTK2 through miR-505-3p.	hsa_circ_0082319	circ_0082319			hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0082319 is up-regulated in HCC tissues, serum and cell lines and is associated with poorer overall survival and potential diagnostic value. Mechanistically, HuR enhances circ_0082319 expression, and circ_0082319 promotes HCC progression by sponging miR-505-3p to elevate PTK2, thereby increasing proliferation, invasion, angiogenesis, glycolysis and tumor growth while inhibiting apoptosis."	0.8824
37878495	"Shock (Augusta, Ga.)"	2024	CIRCUSP42 AMELIORATES LPS-INDUCED HUMAN RENAL EPITHELIAL CELLS IN VITRO BY REGULATING THE MIR-182-5P/DUSP1 AXIS.	hsa_circ_0007823	circUSP42	hsa_circ_USP42	USP42	sepsis-induced AKI 	MONDO:0005229	bacterial infectious disease with sepsis	down-regulated	RT-qPCR	"CircUSP42 (hsa_circ_0007823), derived from USP42, is down-regulated in serum from sepsis-associated AKI patients and in LPS-treated HK2 cells. Its overexpression ameliorates LPS-induced renal epithelial cell injury by promoting proliferation and suppressing apoptosis, inflammation, and oxidative stress. Mechanistically, circUSP42 sponges miR-182-5p to increase DUSP1 expression, forming a circUSP42/miR-182-5p/DUSP1 regulatory axis."	0.7795
37882757	Molecular human reproduction	2023	hsa_circRNA_BECN1 acts as a ceRNA to promote polycystic ovary syndrome progression by sponging the miR-619-5p/Rab5b axis.		hsa_circRNA_BECN1 	hsa_circ_BECN1	BECN1	polycystic ovarian syndrome 	MONDO:0008487	polycystic ovary syndrome	up-regulated	RT-qPCR	"circ_BECN1 is up-regulated in ovarian granulosa cells from PCOS patients. It promotes KGN granulosa-like cell proliferation and cell cycle progression while inhibiting apoptosis, mainly through a ceRNA mechanism involving miR-619-5p and Rab5b. The study proposes circ_BECN1 as a potential therapeutic target for PCOS."	0.8455
37882923	Biochemical genetics	2024	circ_0000337 Promotes the Progression of Cervical Cancer by miR-155-5p/RAB3B Axis.	hsa_circ_0000337	circ_0000337			cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ_0000337 is upregulated in cervical cancer tissues and cell lines. It promotes CC cell proliferation by acting as a ceRNA for miR-155-5p and increasing RAB3B expression, and its high expression is associated with larger tumor size and differentiation."	0.6903
37889059	Cancer genomics & proteomics	2023	Hsa_circ_0079557 Promotes the Proliferation of Colorectal Cancer Cells Through the hsa_circ_0079557/miR-502-5p/CCND1 Axis.	hsa_circ_0079557		hsa_circ_RAPGEF5	RAPGEF5	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0079557 is up-regulated in colorectal cancer tissues and cell lines. It promotes CRC cell proliferation, migration, colony formation, cell cycle progression, and xenograft tumor growth by sponging miR-502-5p and increasing CCND1 protein expression. The proposed hsa_circ_0079557/miR-502-5p/CCND1 pathway may represent a potential diagnostic or therapeutic target in CRC."	0.8175
37890873	Chemical biology & drug design	2024	A novel link between melatonin and circ_0005753/PTBP1/TXNIP regulatory network in the modulation of osteogenic potential in mesenchymal stem cells.	hsa_circ_0005753	circ_0005753			osteoporosis 	MONDO:0005298	osteoporosis	up-regulated	RT-qPCR	"circ_0005753 is up-regulated in OVX-induced OP mouse bone tissue and serum and down-regulated by melatonin during BMSC osteogenic differentiation. It functions as a negative regulator of osteogenesis by recruiting PTBP1 to stabilize TXNIP mRNA, thereby increasing TXNIP expression; melatonin alleviates OP-related osteogenic defects through suppression of the circ_0005753/PTBP1/TXNIP axis."	0.7698
37897547	Cardiovascular research	2023	Exercise-induced circular RNA circUtrn is required for cardiac physiological hypertrophy and prevents myocardial ischaemia-reperfusion injury.	hsa_circ_0001648	circRNA_0191 	hsa_circ_Utrn	Utrn	myocardial ischemia/reperfusion injury 	MONDO:0005203	ischemia reperfusion injury	down-regulated	RT-qPCR; RNA-seq	"circUtrn is an exercise-induced, conserved circRNA derived from Utrn that is downregulated in myocardial ischemia/reperfusion injury models. It promotes physiological cardiac hypertrophy and cardiomyocyte survival, while its overexpression protects against acute I/R injury and pathological cardiac remodeling. Mechanistically, circUtrn binds PP5, promotes PP5 ubiquitin-proteasome-dependent degradation, and activates MAPK/ERK signaling; SF3B1 functions as an upstream regulator."	0.8543
37897547	Cardiovascular research	2023	Exercise-induced circular RNA circUtrn is required for cardiac physiological hypertrophy and prevents myocardial ischaemia-reperfusion injury.	mmu_circ_0000144	circRNA_0191 	mmu_circ_Utrn	Utrn	myocardial ischemia/reperfusion injury 	MONDO:0005203	ischemia reperfusion injury	down-regulated	RT-qPCR; RNA-seq	"circUtrn is an exercise-induced, conserved circRNA derived from Utrn that is downregulated in myocardial ischemia/reperfusion injury models. It promotes physiological cardiac hypertrophy and cardiomyocyte survival, while its overexpression protects against acute I/R injury and pathological cardiac remodeling. Mechanistically, circUtrn binds PP5, promotes PP5 ubiquitin-proteasome-dependent degradation, and activates MAPK/ERK signaling; SF3B1 functions as an upstream regulator."	0.8543
37902305	"Cell cycle (Georgetown, Tex.)"	2023	EIF4A3-regulated hsa_circ_0001445 can inhibit the progression of laryngeal squamous cell carcinoma via hsa-miR-432-5p-dependent up-regulation of RGMA expression.	hsa_circ_0001445		hsa_circ_SMARCA5	SMARCA5	Laryngeal squamous cell carcinoma 	MONDO:0005595	laryngeal squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0001445 is down-regulated in LSCC tissues and cell lines and lower expression is associated with aggressive clinicopathological features and poor overall survival. Functionally, hsa_circ_0001445 suppresses LSCC cell proliferation, migration, invasion and xenograft tumor growth. Mechanistically, EIF4A3 reduces hsa_circ_0001445 expression, while hsa_circ_0001445 acts as a cytoplasmic ceRNA for hsa-miR-432-5p to relieve repression of RGMA."	0.881
37902590	Biomarkers in medicine	2023	Feasibility evaluation of hsa_circ_0005480 as an auxiliary diagnostic and prognostic indicator for gastric cancer.	hsa_circ_0005480		hsa_circ_DCLK2	DCLK2	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"This study identified hsa circ 0005480 as an up-regulated plasma circRNA in gastric cancer using GEO datasets and RT-qPCR validation in clinical plasma samples. It showed diagnostic value alone and in combination with traditional tumor markers, decreased after treatment or surgery, and was proposed as a marker for screening and prognostic assessment. Mechanistically, it was mainly cytoplasmic and predicted to act as a miRNA-binding platform, although direct functional and mechanistic validation was not performed."	0.6895
37904009	Molecular biology reports	2023	The investigation of circRNA profiling reveals the regulatory role of the hsa_circ_0000375/miR-7706 pathway in breast cancer.	hsa_circ_0000375	circ_0000375	hsa_circ_IFFO1	IFFO1	breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0000375 is significantly down-regulated in breast cancer tissues. Its overexpression suppresses breast cancer cell proliferation, migration and invasion, at least partly through sponging miR-7706 and potentially affecting LPL, DGAT2 and ADIPOQ."	0.5923
37904009	Molecular biology reports	2023	The investigation of circRNA profiling reveals the regulatory role of the hsa_circ_0000375/miR-7706 pathway in breast cancer.	hsa_circ_0028899	circ_0028899			breast cancer 	MONDO:0007254	breast cancer	dysregulated	Microarray	"circ_0028899 was identified as a differentially expressed circRNA in breast cancer microarray data and was included in a predicted circRNA-miRNA-mRNA ceRNA network. Its disease association in this paper is supported only by high-throughput and bioinformatics analyses, without reported RT-qPCR or functional validation specific to this circRNA."	0.1768
37904009	Molecular biology reports	2023	The investigation of circRNA profiling reveals the regulatory role of the hsa_circ_0000375/miR-7706 pathway in breast cancer.	hsa_circ_0000376	circ_0000376			breast cancer 	MONDO:0007254	breast cancer	dysregulated	Microarray	"circ_0000376 was identified as a differentially expressed circRNA in breast cancer microarray data and was included in a predicted circRNA-miRNA-mRNA ceRNA network. Its disease association in this paper is supported only by high-throughput and bioinformatics analyses, without reported RT-qPCR or functional validation specific to this circRNA."	0.1768
37913973	Biological psychiatry	2024	Hippocampal circAnk3 Deficiency Causes Anxiety-like Behaviors and Social Deficits by Regulating the miR-7080-3p/IQGAP1 Pathway in Mice.	Mmu_circ_0002381	circAnk3	mmu_circ_Ank3	Ank3	anxiety-like behaviors 	MONDO:0011918	anxiety	down-regulated	RT-qPCR; ISH	"Mouse circAnk3 is a cytoplasmic circRNA derived from Ank3 and is downregulated in the hippocampus under chronic restraint stress and chronic social defeat stress. The study shows that circAnk3 deficiency causes anxiety-like behaviors and social deficits by reducing miR-7080-3p sponging, decreasing Iqgap1/IQGAP1 expression, weakening GluN2a-related synaptic plasticity, and impairing hippocampal dendritic structure."	0.8024
37917325	Molecular biotechnology	2024	"Circular RNA (circ)_0053277 Contributes to Colorectal Cancer Cell Growth, Angiogenesis, Metastasis and Glycolysis."	hsa_circ_0053277		hsa_circ_NRBP1	NRBP1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0053277 is up-regulated in colorectal cancer tissues and cell lines. It functions as an oncogenic circRNA by sponging miR-520 h to increase HK1 expression, thereby promoting CRC cell proliferation, angiogenesis, migration, invasion, metastasis, glycolysis and in vivo tumor growth while suppressing apoptosis. The study suggests circ_0053277 as a potential therapeutic target for CRC."	0.844
37918583	Pharmacological research	2023	CircIQGAP1 regulates RCAN1 and RCAN2 through the mechanism of ceRNA and promotes the growth of malignant glioma.	hsa_circ_0000651	circIQGAP1 	hsa_circ_IQGAP1	IQGAP1	malignant glioma 	MONDO:0100342	malignant glioma	down-regulated	RT-qPCR; RNA-seq	"circIQGAP1 is a human IQGAP1-derived circRNA that is downregulated in IDH1-mutant gliomas compared with IDH1 wild-type gliomas. It promotes malignant glioma growth, migration, invasion and proliferation while suppressing apoptosis, at least partly through ceRNA regulation of the miR-1256/RCAN1/Bax/Bcl-2/Caspase3 and miR-622/RCAN2/Bax/Bcl-2/Caspase3 axes. Clinically, high circIQGAP1 expression is associated with worse prognosis, supporting its role as a prognostic biomarker and potential therapeutic target."	0.8792
37918704	Experimental cell research	2024	Circular RNA SLC8A1 triggers hippocampal neuronal ferroptosis by regulating FUS-mediated ATF3 mRNA stability in epilepsy.		circRNA SLC8A1 	hsa_circ_SLC8A1	SLC8A1	epilepsy	MONDO:0005027	epilepsy	up-regulated	RT-qPCR	"circSLC8A1 is up-regulated in epilepsy patient serum, Mg2+-free-induced HN-h epilepsy cell models, and epilepsy rat hippocampal tissues. It promotes hippocampal neuronal ferroptosis by recruiting the RNA-binding protein FUS to stabilize ATF3 mRNA, and serum circSLC8A1 may serve as a diagnostic biomarker and therapeutic target for epilepsy."	0.8655
37921085	Environmental toxicology	2024	Hsa_circ_0001707 regulates endothelial-mesenchymal transition in esophageal squamous cell carcinoma via miR-203a-3p/Snail2 pathway.	hsa_circ_0001707		hsa_circ_ABCA13	ABCA13	Esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001707 is up-regulated in ESCC tissues and cell lines and is associated with increased ESCC risk and diagnostic biomarker potential. Functionally, it promotes ESCC proliferation, invasion, metastasis and EMT by acting as a ceRNA sponge for miR-203a-3p, thereby relieving repression of Snail2."	0.8455
37925667	Biochemical genetics	2024	CircRNA circ_0013339 Regulates the Progression of Colorectal Cancer Through miR-136-5p/SOX9 Axis.	hsa_circ_0013339	circ_0013339 	hsa_circ_SLC30A7	SLC30A7	Colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0013339 is up-regulated in colorectal cancer tissues and cells and acts as an oncogenic circRNA. It promotes CRC cell proliferation, viability, migration, invasion, and xenograft tumor growth while suppressing apoptosis, mainly through a ceRNA mechanism involving the miR-136-5p/SOX9 axis. The study proposes circ_0013339 as a potential biomarker and therapeutic target for CRC."	0.8175
37927011	Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae	2023	"[Forkhead Box M1 Regulates the Proliferation,Invasion,and Drug Resistance of Gastric Cancer Cells via circ_NOTCH1]."		circ_NOTCH1	hsa_circ_NOTCH1	NOTCH1	gastric cancer	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"This study investigated circ_NOTCH1 in gastric cancer cells. FOXM1 regulates gastric cancer cell proliferation, invasion, and drug resistance through circ_NOTCH1, indicating a FOXM1/circ_NOTCH1 regulatory relationship relevant to malignant cellular behavior and treatment response."	0.5223
37930606	Clinical and experimental medicine	2023	CircZBTB46 predicts poor prognosis and promotes disease progression of myelodysplastic syndromes and acute myeloid leukemia.		circZBTB46	hsa_circ_ZBTB46	ZBTB46	myelodysplastic syndromes 	MONDO:0018881	myelodysplastic syndrome	up-regulated	RT-qPCR; Microarray	"circZBTB46 is a human circRNA derived from ZBTB46 that is up-regulated in bone marrow samples from MDS and AML patients, with higher expression in higher-risk disease states. Clinically, high circZBTB46 expression is associated with adverse disease features, AML transformation, poorer treatment response in AML, and shorter survival. Functionally, circZBTB46 promotes leukemic cell proliferation and cell cycle progression while inhibiting apoptosis."	0.8196
37934513	Acta biochimica Polonica	2023	Competitive binding of circCCDC6 to microRNA-128-3p activates TXNIP/NLRP3 pathway and promotes cerebral ischemia-reperfusion defects.		circCCDC6 	hsa_circ_CCDC6 	CCDC6	cerebral ischemia-reperfusion defects 	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR	"circCCDC6 is up-regulated in MCAO/R rat brain tissues and OGD/R-treated SH-SY5Y cells. It aggravates cerebral ischemia-reperfusion injury by competitively binding miR-128-3p and activating the TXNIP/NLRP3 pathway, thereby promoting neuronal pyroptosis and inflammation. Knockdown of circCCDC6 alleviates neurological injury and inflammatory/pyroptotic changes in the disease models."	0.6278
37934513	Acta biochimica Polonica	2023	Competitive binding of circCCDC6 to microRNA-128-3p activates TXNIP/NLRP3 pathway and promotes cerebral ischemia-reperfusion defects.		circCCDC6 	rno_circ_CCDC6	CCDC6	cerebral ischemia-reperfusion defects 	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR	"circCCDC6 is up-regulated in MCAO/R rat brain tissues and OGD/R-treated SH-SY5Y cells. It aggravates cerebral ischemia-reperfusion injury by competitively binding miR-128-3p and activating the TXNIP/NLRP3 pathway, thereby promoting neuronal pyroptosis and inflammation. Knockdown of circCCDC6 alleviates neurological injury and inflammatory/pyroptotic changes in the disease models."	0.6278
37939881	The American journal of the medical sciences	2024	CircHDAC9 regulates myocardial ischemia-reperfusion injury via miR-671-5p/SOX4 signaling axis.	hsa_circ_0003594	circHDAC9 	hsa_circ_HDAC9	HDAC9	myocardial ischemia-reperfusion injury 	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR	"circHDAC9 is up-regulated in hypoxia/reoxygenation-treated human cardiac myocytes and in myocardial ischemia/reperfusion injury mice. Its knockdown alleviates myocardial injury by reducing apoptosis, oxidative stress and inflammation, acting through a ceRNA mechanism involving miR-671-5p and SOX4."	0.6585
37942847	Journal of biochemical and molecular toxicology	2024	CircFNTA promotes tumorigenesis and progression of gastric cancer via miR-604/miR-647/SCN8A axis.		circFNTA	hsa_circ_FNTA	FNTA	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circFNTA is upregulated in gastric cancer tissues and cell lines, and high expression is associated with poor patient prognosis. Functionally, circFNTA promotes proliferation, metastasis, EMT and tumor growth. Mechanistically, it sponges miR-604 and miR-647 to upregulate SCN8A, forming the circFNTA/miR-604/miR-647/SCN8A axis."	0.8298
37944732	International journal of biological macromolecules	2024	CircDYM attenuates microglial apoptosis via CEBPB/ZC3H4 axis in LPS-induced mouse model of depression.		circDYM 	mmu_circ_DYM	DYM	Major depressive disorder 	MONDO:0002009	major depressive disorder	down-regulated	RT-qPCR; ISH	"circDYM is decreased in the hippocampus of LPS-induced depressive mice and its overexpression alleviates depressive-like behaviors. Mechanistically, circDYM binds CEBPB in the cytoplasm, suppresses CEBPB nuclear translocation, modulates ZC3H4 expression, and inhibits autophagy-mediated microglial apoptosis."	0.6682
37945969	Cancer gene therapy	2024	Identification of circATG9A as a novel biomarker for renal cell carcinoma.	hsa_circ_0058358	circATG9A 	hsa_circ_ATG9A	ATG9A	renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circATG9A is a human circRNA derived from ATG9A and is up-regulated in RCC/ccRCC tissues and RCC cell lines. It promotes RCC cell proliferation, migration, invasion, tumor growth, and EMT by sponging miR-497-5p to regulate TRPM3 and activate the Wnt/beta-catenin pathway. Clinically, circATG9A expression is associated with tumor features and prognosis, suggesting potential value as a prognostic and therapeutic target."	0.8933
37951323	Developmental and comparative immunology	2024	"The expression, function, and network regulation of circDNAJB6 in chicken macrophages under lipopolysaccharide (LPS) stimulation."		circular RNA DNAJB6 	gga_circ_DNAJB6	DNAJB6	bacterial infection 	MONDO:0005113	bacterial infectious disease	up-regulated	RNA-seq	"Chicken circDNAJB6 is a stable circular RNA derived from exons 2 to 5 of DNAJB6 and is highly expressed in APEC-infected chicken macrophages. In LPS-stimulated chicken macrophages, circDNAJB6 overexpression aggravates cellular injury, decreases cell viability, and increases NO and pro-inflammatory cytokine production. Bioinformatics analysis predicts a circDNAJB6-miRNA-mRNA network involving five miRNAs and 75 target genes enriched in autophagy-animal and MAPK signaling pathways."	0.6475
37952105	Carcinogenesis	2024	CircCDK17 promotes the proliferation and metastasis of ovarian cancer cells by sponging miR-22-3p to regulate CD147 expression.	hsa_circ_0027803	circCDK17	hsa_circ_CDK17	CDK17	ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"In ovarian cancer, circCDK17 is up-regulated in tumor tissues and cell lines and its high expression is associated with shorter patient survival. Functionally, circCDK17 promotes OC cell proliferation, migration, invasion, EMT-related changes, tumor growth and metastasis. Mechanistically, it sponges miR-22-3p to up-regulate CD147 expression, forming a circCDK17/miR-22-3p/CD147 regulatory axis."	0.8642
37953520	Journal of proteome research	2023	Molecular Mechanism of Circ_0088300-BOLL Interaction Regulating Mitochondrial Metabolic Reprogramming and Involved in Gastric Cancer Growth and Metastasis.	hsa_circ_0088300	circ_0088300 			gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"This study identifies hsa_circ_0088300/circ_0088300 as an upregulated circRNA in gastric cancer-related GEO data. circ_0088300 interacts with the RBP BOLL and increases BOLL protein expression, thereby promoting glycolysis, mitochondrial metabolic reprogramming, proliferation, migration, invasion, EMT, and gastric cancer growth and metastasis. The circ_0088300/BOLL axis is proposed as a potential therapeutic target and diagnostic biomarker, although prognostic relevance remains unconfirmed."	0.657
37955049	Chemical biology & drug design	2024	Tanshinone IIA attenuates ox-LDL-induced endothelial cell injury by inhibiting NF-kapaB pathway via circ_0000231/miR-590-5p/TXNIP axis.	hsa_circ_0000231	circ_0000231			atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"circ_0000231 is up-regulated in AS patient serum and ox-LDL-treated HUVECs. It promotes ox-LDL-induced endothelial cell dysfunction by sponging miR-590-5p to increase TXNIP expression and activate NF-kappaB signaling, thereby enhancing apoptosis, inflammation and oxidative injury while inhibiting proliferation. TSIIA exerts protective effects partly by downregulating circ_0000231 and suppressing the circ_0000231/miR-590-5p/TXNIP axis."	0.7591
37955304	Chemical biology & drug design	2024	"Propofol inhibits the proliferation, invasion, migration, and angiogenesis of oral squamous cell carcinoma through circ_0008898-mediated pathway."	hsa_circ_0008898	circ_0008898	hsa_circ_OAT	OAT	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circ_0008898 is up-regulated in OSCC tissues and cells and is associated with lymph node metastasis, TNM stage, and tumor size. Functionally, circ_0008898 promotes OSCC proliferation, invasion, migration, angiogenesis, and tumor growth while suppressing apoptosis. Mechanistically, propofol decreases circ_0008898 expression, and circ_0008898 regulates the miR-545-3p/CRKL axis to mediate OSCC progression."	0.8171
37956874	International journal of sports medicine	2024	CircRNA Larp4b/miR-298-5p/Mef2c Regulates Cardiac Hypertrophy Induced by Angiotensin II.		circ_Larp4b 	mmu_circ_Larp4b	Larp4b	Cardiac hypertrophy 	MONDO:0001302	hypertensive heart disease	up-regulated	RT-qPCR	"circ_Larp4b is up-regulated in Ang II-induced HL-1 cardiac hypertrophy cells and promotes hypertrophic progression. Mechanistically, circ_Larp4b sponges miR-298-5p to regulate Mef2c, increasing hypertrophic cell size and marker expression; circ_Larp4b knockdown reverses these effects."	0.7328
37962045	Protein and peptide letters	2024	Novel Circular RNA CircUBAP2 Drives Tumor Progression by Regulating the miR-143/TFAP2B Axis in Prostate Cancer.		CircUBAP2 	hsa_circ_UBAP2	UBAP2	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"CircUBAP2 is up-regulated in prostate cancer tissues and cells and functions as an oncogenic circRNA. Mechanistically, it sponges miR-143 to enhance TFAP2B expression, thereby promoting cell viability, migration, invasion, EMT and in vivo tumor growth while suppressing apoptosis. The study suggests circUBAP2 may be a therapeutic target in prostate cancer."	0.713
37962691	Biochemical genetics	2024	Circ_0003789 Knockdown Inhibits Tumor Progression by miR-429/ZFP36L2 Axis in Gastric Cancer.	hsa_circ_0003789		hsa_circ_TSN	TSN	gastric cancer	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_0003789 is up-regulated in gastric cancer tissues and cells. It promotes gastric cancer progression by sponging miR-429 and increasing ZFP36L2 expression, thereby enhancing proliferation, colony formation, invasion and xenograft tumor growth while suppressing apoptosis. The study suggests circ_0003789 may be a therapeutic target for gastric cancer."	0.7597
37962954	"Shock (Augusta, Ga.)"	2024	CIRC_0033530 KNOCKDOWN ALLEVIATES LIPOPOLYSACCHARIDE-INDUCED ACUTE LUNG INJURY MODEL OF HUMAN LUNG FIBROBLASTS BY MIR-1184/TLR4 AXIS.	hsa_circ_0033530		hsa_circ_TDRD9	TDRD9	sepsis-associated acute lung injury 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR	"Circ_0033530 is up-regulated in sepsis patients and LPS-induced MRC-5 human lung fibroblasts. Its knockdown alleviates LPS-induced growth inhibition, G1 cell cycle arrest, apoptosis, and inflammatory cytokine release by sponging miR-1184 and regulating TLR4 expression through the circ_0033530/miR-1184/TLR4 ceRNA axis."	0.7799
37963200	Cancer research	2024	"CircMMP2(6,7) Cooperates with beta-Catenin and PRMT5 to Disrupt Bone Homeostasis and Promote Breast Cancer Bone Metastasis."	hsa_circ_0039408		hsa_circ_MMP2	MMP2	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circMMP2(6,7), also identified as hsa_circ_0039408, is up-regulated in bone metastatic breast cancer and predicts shorter bone metastasis-free survival. It promotes osteolytic bone metastasis by disrupting bone homeostasis through increased osteoclastogenesis and suppressed osteoblastogenesis. Mechanistically, it forms a promoter-associated circMMP2(6,7)/beta-catenin/PRMT5 complex that epigenetically activates S100A4 and LGALS3 transcription, and PRMT5 inhibition with GSK591 blocks this pro-metastatic program."	0.8908
37963204	Molecular reproduction and development	2024	The molecular mechanism of naringin improving endometrial receptivity of OHSS rats.		rno-circ_008140 			ovarian hyperstimulation syndrome 	MONDO:0011972	ovarian hyperstimulation syndrome	up-regulated	RT-qPCR; RNA-seq	"rnocirc_008140 is up-regulated in the uterus/endometrium of OHSS model rats and is down-regulated by naringin treatment. The study proposes that naringin improves endometrial receptivity and embryo implantation success partly by reducing rnocirc_008140-mediated miRNA adsorption, thereby regulating Abcc4 and Rps6ka5 expression."	0.5079
37966490	Carcinogenesis	2024	Splicing factor ESRP1 derived circ_0068162 promotes the progression of oral squamous cell carcinoma via the miR-186/JAG axis.	hsa_circ_0068162	circ_0068162 	hsa_circ_MCF2L2	MCF2L2	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0068162 is an up-regulated human circRNA derived from MCF2L2 in OSCC. It promotes OSCC progression by sponging miR-186 and regulating JAG1/JAG2, while ESRP1 enhances its biosynthesis; high circ_0068162 expression is associated with poorer patient survival."	0.887
37966664	Molecular biotechnology	2024	Circular RNA PIP5K1A Promotes Glucose and Lipid Metabolism Disorders and Inflammation in Type 2 Diabetes Mellitus.		circPIP5K1A 	rno_circ_PIP5K1A	PIP5K1A	Type 2 diabetes mellitus 	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RT-qPCR	"circPIP5K1A is up-regulated in HFD/STZ-induced T2DM rats and appears to worsen insulin resistance, glucose and lipid metabolism disorders, inflammation, and pancreatic pathology. Silencing circPIP5K1A ameliorates these T2DM phenotypes through a miR-552-3p/ENO1 regulatory mechanism, suggesting circPIP5K1A inhibition as a potential therapeutic strategy."	0.5607
37968534	Biochemical genetics	2024	Circular RNA hsa_circ_0000175 Serves as a Potential Biomarker for Rheumatoid Arthritis via miR-31-5p/GSDME Axis.	hsa_circ_0000175		hsa_circ_ELK4	ELK4	Rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"hsa_circ_0000175/circ_0000175 is up-regulated in PBMCs of RA patients and in LPS/ATP-treated RA-FLSs. It promotes inflammatory pyroptosis by sponging miR-31-5p and increasing GSDME-related signaling through caspase-3/GSDME and caspase-1/GSDMD pathways. Its expression can distinguish RA patients from healthy controls and correlates with RA severity indicators, suggesting diagnostic and therapeutic relevance."	0.7745
37974391	"Cell cycle (Georgetown, Tex.)"	2023	Exosome-delivered circRNA circSYT15 contributes to cisplatin resistance in cervical cancer cells through the miR-503-5p/RSF1 axis.	hsa_circ_0018289	circSYT15 	hsa_circ_SYT15	synaptotagmin 15	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circSYT15 is upregulated in DDP-resistant cervical cancer cells and serum/cell-derived exosomes. Exosome-delivered circSYT15 promotes proliferation, tumor growth and cisplatin resistance while inhibiting apoptosis, partly through sponging miR-503-5p and increasing RSF1 expression. Its elevated serum exosomal expression is associated with DDP resistance in cervical cancer patients."	0.7754
37976602	International immunopharmacology	2023	"CircMIRLET7BHG, upregulated in an m6A-dependent manner, induces the nasal epithelial barrier dysfunction in allergic rhinitis pathogenesis."	hsa_circ_0008668	circMIRLET7BHG 	hsa_circ_MIRLET7BHG	MIRLET7BHG	allergic rhinitis 	MONDO:0011786	allergic rhinitis	up-regulated	RT-qPCR; ISH	"circMIRLET7BHG (hsa_circ_0008668) is up-regulated in allergic rhinitis patient nasal mucosa and in OVA-induced cellular and mouse models. METTL3 enhances circMIRLET7BHG expression through m6A modification, and circMIRLET7BHG promotes nasal epithelial barrier dysfunction by recruiting IGF2BP1 to stabilize ADAM10 mRNA. Silencing circMIRLET7BHG alleviates allergic nasal symptoms, inflammation, apoptosis, eosinophil infiltration and epithelial barrier damage, suggesting therapeutic relevance in AR."	0.8354
37980036	Journal of environmental sciences (China)	2024	circRNAs deregulation in exosomes derived from BEAS-2B cells is associated with vascular stiffness induced by PM2.5.	hsa_circ_0012627				vascular stiffness 	MONDO:0005385	vascular disorder	up-regulated	RT-qPCR; Microarray	"hsa_circ_0012627 is an up-regulated exosomal circRNA released by PM2.5-treated BEAS-2B cells. The study links it to vascular endothelial dysfunction through a predicted exosomal ceRNA network involving MAPK8 and RALA, suggesting potential value as a biomarker for PM2.5-related vascular injury."	0.2465
37980036	Journal of environmental sciences (China)	2024	circRNAs deregulation in exosomes derived from BEAS-2B cells is associated with vascular stiffness induced by PM2.5.	hsa_circ_0053261				vascular stiffness 	MONDO:0005385	vascular disorder	up-regulated	RT-qPCR; Microarray	"hsa_circ_0053261 is an up-regulated exosomal circRNA released by PM2.5-treated BEAS-2B cells. The study links it to vascular endothelial dysfunction through a predicted exosomal ceRNA network involving MAPK8 and RALA, suggesting potential value as a biomarker for PM2.5-related vascular injury."	0.2465
37980036	Journal of environmental sciences (China)	2024	circRNAs deregulation in exosomes derived from BEAS-2B cells is associated with vascular stiffness induced by PM2.5.	hsa_circ_0052810				vascular stiffness 	MONDO:0005385	vascular disorder	up-regulated	RT-qPCR; Microarray	"hsa_circ_0052810 is an up-regulated exosomal circRNA released by PM2.5-treated BEAS-2B cells. The study links it to vascular endothelial dysfunction through a predicted exosomal ceRNA network involving MAPK8 and RALA, suggesting potential value as a biomarker for PM2.5-related vascular injury."	0.2465
37981069	Cellular signalling	2024	CircFSCN1 induces tumor progression and triggers epithelial-mesenchymal transition in bladder cancer through augmentation of MDM2-mediated p53 silencing.	hsa_circ_0079283	circFSCN1	hsa_circ_FSCN1	FSCN1	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"circFSCN1 is a human FSCN1-derived circRNA up-regulated in bladder cancer tissues and cell lines. It promotes BC proliferation, migration, invasion, EMT, and xenograft tumor growth by sponging miR-145-5p to increase MDM2 and suppress p53 signaling. High circFSCN1 expression is associated with aggressive clinicopathologic features and poor cancer-specific survival."	0.9003
37981258	European journal of pharmacology	2023	Circ-Plod2 destabilizes Mpo mRNA by binding to IGF2BP2 to promote osteogenic differentiation of bone marrow mesenchymal stem cells.		circRNA307 	rno_circ_Plod2	Plod2	postmenopausal osteoporosis 	MONDO:0008159	postmenopausal osteoporosis	down-regulated	RT-qPCR; RNA-seq	"circ-Plod2 is down-regulated in OVX rat BMSCs and bone marrow in a PMO model. It localizes mainly to the cytoplasm, binds the RNA-binding protein IGF2BP2, destabilizes Mpo mRNA, suppresses Mpo/MPO expression, promotes Mpo-dependent osteogenic differentiation of BMSCs, and alleviates osteoporosis in OVX rats."	0.7731
37981775	Zhonghua yi xue za zhi	2023	"[The mechanism by which hsa_circRNA_103124 highly expressed in peripheral blood of patients with active Crohn's disease regulates macrophage differentiation, pyroptosis and inflammation]."		hsa_circRNA_103124 			active Crohn's disease 	MONDO:0005011	Crohn disease	up-regulated	RT-qPCR	"hsa_circRNA_103124 is up-regulated in PBMC from patients with active Crohn's disease and its abundance correlates positively with TLR4 expression and CDAI. Functional experiments in THP1-derived macrophage-like cells indicate that hsa_circRNA_103124 promotes M1 macrophage differentiation, ROS production, inflammatory cytokine expression and pyroptosis-related factors, likely through the TLR4/MyD88/NLRP3/GSDMD axis. It may have clinical value as a non-invasive indicator of Crohn's disease activity."	0.5214
37982201	Anti-cancer drugs	2025	circ_0006528 promotes nonsmall cell lung cancer progression by sponging miR-892a and regulating NRAS expression.	hsa_circ_0006528	circ_0006528 	hsa_circ_PRELID2	PRELID2	nonsmall cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0006528 is up-regulated in NSCLC tissues and cell lines and high expression is associated with poor prognosis. Functionally, circ_0006528 promotes NSCLC proliferation, migration, invasion, EMT, and xenograft tumor growth. Mechanistically, it sponges miR-892a to positively regulate NRAS expression."	0.859
37982234	The International journal of neuroscience	2025	CircFKBP3 absence alleviates oxygen glucose deprivation-induced function loss of human brain microvascular endothelial cells in vitro via governing the miR-766-3p/TRAF3 axis.	hsa_circ_0101874	circRNA FKBP Prolyl isomerase 3	hsa_circ_FKBP3	FKBP3	ischemic stroke 	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR	"This study shows that circFKBP3 is up-regulated in OGD-treated human brain microvascular endothelial cells, an in vitro model of ischemic stroke. circFKBP3 knockdown alleviates OGD-induced endothelial function loss and inflammation by releasing miR-766-3p and suppressing TRAF3, suggesting the circFKBP3/miR-766-3p/TRAF3 axis as a potential therapeutic target."	0.7827
37982910	Functional & integrative genomics	2023	Hypoxia-induced circRTN4IP1 promotes progression and glycolysis of hepatocellular carcinoma cells.		circRTN4IP1 	hsa_circ_RTN4IP1	RTN4IP1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"This study found that hypoxia up-regulates circRTN4IP1 in HCC cells. HIF1A transcriptionally induces circRTN4IP1, and circRTN4IP1 promotes hypoxia-associated HCC cell proliferation, migration, invasion, and glycolysis through the miR-532-5p/G6PC3 ceRNA axis."	0.7581
37984605	Cellular signalling	2024	Circular RNA CircSATB2 facilitates osteosarcoma progression through regulating the miR-661/FUS-mediated mRNA of ZNFX1.		CircSATB2 	hsa_circ_SATB2	SATB2	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circSATB2 is up-regulated in osteosarcoma tissues and cell lines, and its high expression is associated with poor overall survival, advanced Enneking stage, and distant metastasis. Functionally, circSATB2 promotes osteosarcoma proliferation, migration, invasion, tumor growth, and lung metastasis. Mechanistically, it acts through a miR-661/ZNFX1 ceRNA route and also interacts with FUS to regulate/stabilize ZNFX1 mRNA."	0.8981
37987463	Environmental toxicology	2024	The identification and functional analysis of CircRNAs in endometrial receptivity of mice with polycystic ovary.		circRNA_38548	mmu_circ_Rictor	Rictor	polycystic ovary syndrome 	MONDO:0008487	polycystic ovary syndrome	up-regulated	RT-qPCR; Microarray	"This circRNA is upregulated in the endometrium of PCOS mice during the implantation window and is implicated in abnormal endometrial receptivity. Functional experiments suggest it promotes endometrial epithelial cell proliferation, migration, and invasion while inhibiting apoptosis, likely through a miRNA sponge/ceRNA mechanism that regulates downstream genes including Lifr, FOXK1, FOXO1, and HOXA10."	0.7296
37987463	Environmental toxicology	2024	The identification and functional analysis of CircRNAs in endometrial receptivity of mice with polycystic ovary.		circRNA_001686			polycystic ovary syndrome 	MONDO:0008487	polycystic ovary syndrome	up-regulated	RT-qPCR; Microarray	"This circRNA is upregulated in the endometrium of PCOS mice during the implantation window and is implicated in abnormal endometrial receptivity. Functional experiments suggest it promotes endometrial epithelial cell proliferation, migration, and invasion while inhibiting apoptosis, likely through a miRNA sponge/ceRNA mechanism that regulates downstream genes including Lifr, FOXK1, FOXO1, and HOXA10."	0.7296
37987463	Environmental toxicology	2024	The identification and functional analysis of CircRNAs in endometrial receptivity of mice with polycystic ovary.		circRNA_38550			polycystic ovary syndrome 	MONDO:0008487	polycystic ovary syndrome	up-regulated	RT-qPCR; Microarray	"This circRNA is upregulated in the endometrium of PCOS mice during the implantation window and is implicated in abnormal endometrial receptivity. Functional experiments suggest it promotes endometrial epithelial cell proliferation, migration, and invasion while inhibiting apoptosis, likely through a miRNA sponge/ceRNA mechanism that regulates downstream genes including Lifr, FOXK1, FOXO1, and HOXA10."	0.7296
37987463	Environmental toxicology	2024	The identification and functional analysis of CircRNAs in endometrial receptivity of mice with polycystic ovary.		circRNA_27938			polycystic ovary syndrome 	MONDO:0008487	polycystic ovary syndrome	down-regulated	RT-qPCR; Microarray	"This circRNA is downregulated in PCOS mouse endometrium during the implantation window and may be linked to defective endometrial receptivity. The paper suggests a possible relationship with IGF1R, but the mechanism is largely hypothetical and not experimentally validated in this study."	0.5135
37987500	Environmental toxicology	2024	Circ_0082878 contributes to prostate cancer progression via the miR-455-3p/WTAP axis.	hsa_circ_0082878	Circ_0082878 	hsa_circ_SSPO	SSPO	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	"circ_0082878 is up-regulated in prostate cancer tissues and cells and functions as an oncogenic circRNA. It promotes proliferation, migration, invasion, and xenograft tumor growth by sponging miR-455-3p and upregulating WTAP, suggesting the circ_0082878/miR-455-3p/WTAP axis as a potential therapeutic target."	0.7968
37989109	Ophthalmic research	2023	Identification of Cuproptosis-Related circRNA-miRNA-mRNA Network in Laser-Induced Choroidal Neovascularization Models and in Peripheral Blood Mononuclear Cells of Patients with Neovascular Age-Related Macular Degeneration.		circNPEPPS 	hsa_circ_NPEPPS	NPEPPS	neovascular age-related macular degeneration 	MONDO:0003004	macular degeneration	up-regulated	RT-qPCR; Microarray	"circNPEPPS was significantly up-regulated in PBMC samples from patients with nAMD. The study identifies it as the key upstream circRNA in a predicted cuproptosis-related circNPEPPS/miR-129-5p/MTF1 ceRNA axis, with potential relevance as a biomarker or therapeutic target."	0.4997
37989109	Ophthalmic research	2023	Identification of Cuproptosis-Related circRNA-miRNA-mRNA Network in Laser-Induced Choroidal Neovascularization Models and in Peripheral Blood Mononuclear Cells of Patients with Neovascular Age-Related Macular Degeneration.		circZNF644 	hsa_circ_ZNF644	ZNF644	neovascular age-related macular degeneration 	MONDO:0003004	macular degeneration	down-regulated	RT-qPCR; Microarray	"circZNF644 was significantly down-regulated in PBMC samples from patients with nAMD. It was included in the study's cuproptosis-related circRNA-miRNA-mRNA network, but the paper did not experimentally validate a specific mechanistic axis for this circRNA."	0.4997
37989109	Ophthalmic research	2023	Identification of Cuproptosis-Related circRNA-miRNA-mRNA Network in Laser-Induced Choroidal Neovascularization Models and in Peripheral Blood Mononuclear Cells of Patients with Neovascular Age-Related Macular Degeneration.		circTKT	hsa_circ_TKT	TKT	neovascular age-related macular degeneration 	MONDO:0003004	macular degeneration	down-regulated	RT-qPCR; Microarray	"circTKT was significantly down-regulated in PBMC samples from patients with nAMD. It was included in the cuproptosis-related circRNA-miRNA-mRNA network, although the paper did not define a circTKT-specific validated molecular mechanism."	0.4997
37989109	Ophthalmic research	2023	Identification of Cuproptosis-Related circRNA-miRNA-mRNA Network in Laser-Induced Choroidal Neovascularization Models and in Peripheral Blood Mononuclear Cells of Patients with Neovascular Age-Related Macular Degeneration.		circMAMIL1 	hsa_circ_MAMIL1	MAMIL1	neovascular age-related macular degeneration 	MONDO:0003004	macular degeneration	down-regulated	RT-qPCR; Microarray	"circMAMIL1 was reported in the figure caption as significantly down-regulated in PBMC samples from patients with nAMD. It was included in the cuproptosis-related circRNA-miRNA-mRNA network, but no circMAMIL1-specific functional mechanism was experimentally validated."	0.4997
37994026	Autoimmunity	2023	Circ_0006944 aggravates LPS-induced HK2 cell injury via modulating miR-205-5p/UBL4A pathway.	hsa_circ_0006944	circ_0006944	hsa_circ_GTF2I	GTF2I	sepsis-associated acute kidney injury 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR	"Circ_0006944 is up-regulated in serum from SA-AKI patients and in LPS-treated HK2 cells. It aggravates LPS-induced HK2 cell injury by suppressing proliferation and promoting apoptosis, inflammation and oxidative stress, acting through the miR-205-5p/UBL4A axis. The study suggests circ_0006944 may serve as a diagnostic and therapeutic biomarker for SA-AKI."	0.817
37999809	Journal of bioenergetics and biomembranes	2024	Circ_0001944 depletion inhibits glycolysis and esophageal cancer progression by binding to miR-338-5p to reduce PDK1 expression.	hsa_circ_0001944	circ_0001944			esophageal cancer 	MONDO:0007576	esophageal cancer	up-regulated	RT-qPCR; Microarray	"Circ_0001944 is up-regulated in esophageal cancer tissues and cells, and high expression is associated with poor prognosis. Functional experiments indicate that circ_0001944 promotes EC proliferation, invasion, migration, glycolysis and xenograft growth while suppressing apoptosis. Mechanistically, circ_0001944 acts as a miR-338-5p sponge to increase PDK1 expression, forming a circ_0001944/miR-338-5p/PDK1 regulatory axis."	0.8202
38000773	Experimental cell research	2023	Circular RNA DLGAP4 alleviates sevoflurane-induced neurotoxicity by regulating miR-9-5p/Sirt1/BDNF pathway.		Circular RNA DLGAP4 	mmu_circ_DLGAP4	DLGAP4	sevoflurane-induced neurotoxicity 	MONDO:0005527	toxic encephalopathy	down-regulated	RT-qPCR	"In sevoflurane-induced neurotoxicity models, circDLGAP4 is down-regulated in mouse hippocampus and HT22 cells. Functional experiments show that circDLGAP4 overexpression protects against neuronal injury by increasing cell viability and reducing apoptosis and inflammatory cytokines, while knockdown has opposite effects. Mechanistically, circDLGAP4 sponges miR-9-5p to positively regulate the Sirt1/BDNF pathway."	0.6966
38007007	International journal of biological macromolecules	2024	circWSB1 promotes tumor progression in ccRCC via circWSB1/miR-182-5p/WSB1 axis.	hsa_circ_0007716		hsa_circ_WSB1	WSB1	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR; Microarray	"circWSB1 (hsa_circ_0007716), derived from WSB1, is up-regulated in ccRCC tissues and cell lines. It acts as a cytoplasmic ceRNA by sponging miR-182-5p, thereby increasing WSB1 expression and promoting ccRCC proliferation, migration, and xenograft tumor growth. High circWSB1 expression is associated with poorer clinical prognosis and pathological grading, supporting its potential as a predictive biomarker and therapeutic target."	0.8512
38008051	Journal of hazardous materials	2024	Thiram exposure induces tibial dyschondroplasia in broilers via the regulation effect of circ_003084/miR-130c-5p/BMPR1A crosstalk on chondrocyte proliferation and differentiation.		circ_003084	gga_circ_RABGEF1	RABGEF1	tibial dyschondroplasia 	MONDO:0005583	non-human animal disease	up-regulated	RT-qPCR; RNA-seq	"In thiram-induced tibial dyschondroplasia in broilers, circ_003084 is up-regulated in cartilage and functions as a cytoplasmic ceRNA. It sponges miR-130c-5p to increase BMPR1A expression, thereby inhibiting TD chondrocyte proliferation and differentiation while promoting apoptosis."	0.769
38009649	Environmental toxicology	2024	CircVMP1 promotes glycolysis and disease progression by upregulating HKDC1 in colorectal cancer.	hsa_circ_0006508	circVMP1	hsa_circ_VMP1	VMP1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"circVMP1 is upregulated in colorectal cancer tissues and functions as a tumor-promoting circRNA. It enhances proliferation, migration/metastasis, EMT, glycolysis and xenograft growth while suppressing apoptosis and reducing oxaliplatin chemosensitivity. Mechanistically, circVMP1 mainly acts through the circVMP1/miR-3167/HKDC1 ceRNA axis to increase HKDC1 expression and activate glycolysis."	0.8252
38010029	"Shock (Augusta, Ga.)"	2024	KNOCKDOWN OF CIRC_0114428 ALLEVIATES LPS-INDUCED HK2 CELL APOPTOSIS AND INFLAMMATION INJURY VIA TARGETING MIR-215-5P/TRAF6/NF-kappaB AXIS IN SEPTIC ACUTE KIDNEY INJURY.	hsa_circ_0114428	circ_0114428			septic acute kidney injury 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR	"circ_0114428 is up-regulated in serum from sepsis-AKI patients and in LPS-treated human renal tubular epithelial cells. Its knockdown alleviates LPS-induced injury by promoting proliferation while reducing apoptosis and inflammatory cytokine production. Mechanistically, circ_0114428 sponges miR-215-5p to regulate TRAF6 and NF-kappaB signaling."	0.7591
38010085	"Shock (Augusta, Ga.)"	2024	CIRC-MARC2 SILENCING PROTECTS HUMAN CARDIOMYOCYTES FROM HYPOXIA/REOXYGENATION-INDUCED INJURY BY MODULATING MIR-335-5P/TRPM7 AXIS.	hsa_circ_0112085	circ-MARC2 	hsa_circ_MARC2	MARC2	myocardial ischemia/reperfusion injury 	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR	"This study shows that circ-MARC2 is up-regulated in H/R-treated human AC16 cardiomyocytes. Functionally, circ-MARC2 promotes H/R-induced cell injury by inhibiting proliferation and enhancing apoptosis and myocardial injury marker activity. Mechanistically, circ-MARC2 acts as a ceRNA for miR-335-5p to increase TRPM7 expression."	0.7394
38010112	"Shock (Augusta, Ga.)"	2024	CIRC_0003907 MODULATES SEPSIS-INDUCED MYOCARDIAL INJURY VIA ENHANCING MYD88/NLRP3/NF-kappaB AXIS BY SPONGING MIR-944.	hsa_circ_0003907	circ_0003907 			Sepsis-induced cardiomyopathy 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR	"Circ_0003907 is up-regulated in serum from SIC patients and in LPS-treated human AC16 cardiomyocytes. Functionally, circ_0003907 aggravates sepsis-induced myocardial injury by inhibiting proliferation and promoting apoptosis, inflammation, and oxidative stress, largely through sponging miR-944 to enhance MYD88/NLRP3/NF-kappaB signaling. Its increased serum expression suggests potential diagnostic and/or prognostic value for SIC."	0.779
38016613	International journal of biological macromolecules	2024	CircIRAK3 exerts negative feedback regulation on inflammation by binding to HNRNP U and destabilizing proinflammatory cytokine mRNA in osteoarthritis and chondrogenesis.	hsa_circ_0005505	circIRAK3 	hsa_circ_IRAK3	IRAK3	osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; ISH; RNA-seq; Microarray	"circIRAK3 is up-regulated in OA cartilage and plasma and acts as a compensatory anti-inflammatory regulator. It binds HNRNP U, reduces HNRNP U-mediated stabilization of IL-1beta, TNF-alpha, and IL-6 mRNAs, and thereby promotes proinflammatory cytokine mRNA degradation. Functionally, circIRAK3 protects chondrocytes, supports hBMSC chondrogenesis, delays DMM-induced cartilage degeneration, and may serve as an OA biomarker and therapeutic target."	0.8834
38016613	International journal of biological macromolecules	2024	CircIRAK3 exerts negative feedback regulation on inflammation by binding to HNRNP U and destabilizing proinflammatory cytokine mRNA in osteoarthritis and chondrogenesis.		mmu_circIRAK3	mmu_circ_IRAK3	IRAK3	osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; ISH; RNA-seq; Microarray	"circIRAK3 is up-regulated in OA cartilage and plasma and acts as a compensatory anti-inflammatory regulator. It binds HNRNP U, reduces HNRNP U-mediated stabilization of IL-1beta, TNF-alpha, and IL-6 mRNAs, and thereby promotes proinflammatory cytokine mRNA degradation. Functionally, circIRAK3 protects chondrocytes, supports hBMSC chondrogenesis, delays DMM-induced cartilage degeneration, and may serve as an OA biomarker and therapeutic target."	0.8834
38018210	Combinatorial chemistry & high throughput screening	2025	Hsa_circ_0001278 Facilitates Colorectal Cancer Progression via Sponging miR-338-5p and Regulating AMOTL1 Expression.	hsa_circ_0001278				Colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001278 is upregulated in colorectal cancer tissues and cell lines and appears to act as an oncogenic circRNA. It promotes CRC cell proliferation, migration and cell cycle progression while inhibiting apoptosis, mainly through the hsa_circ_0001278/miR-338-5p/AMOTL1 ceRNA axis. The study suggests hsa_circ_0001278 may be a potential therapeutic target for CRC."	0.7028
38024586	Intractable & rare diseases research	2023	Circ_KIAA0922 regulates Saos-2 cell proliferation and osteogenic differentiation by regulating the miR-148a-3p/SMAD5 axis and activating the TGF-beta signaling pathway.		circ_KIAA0922 	hsa_circ_KIAA0922	KIAA0922	osteoporosis 	MONDO:0005298	osteoporosis	unknown	RT-qPCR	"circ_KIAA0922 is a human KIAA0922-derived circRNA studied in an in vitro osteoporosis-related osteogenic differentiation model using Saos-2 cells. It promotes Saos-2 proliferation and osteogenic differentiation by sponging miR-148a-3p, relieving repression of SMAD5, and activating the TGF-beta signaling pathway. The study suggests circ_KIAA0922 may be a potential diagnostic biomarker and therapeutic target for improving osteogenic differentiation in OP."	0.7905
38029538	Cancer letters	2024	A novel axis of circKIF4A-miR-637-STAT3 promotes brain metastasis in triple-negative breast cancer.	hsa_circ_0007255	circKIF4A 	hsa_circ_KIF4A	KIF4A	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"circKIF4A is up-regulated in TNBC brain metastases and TNBC cell lines. It promotes TNBC proliferation, migration, invasion, tumor growth, and brain metastasis by sponging miR-637 to up-regulate STAT3, thereby modulating autophagy-related signaling. The study proposes circKIF4A as a potential biomarker and therapeutic target for TNBC brain metastasis."	0.7955
38029946	Cellular signalling	2024	Sevoflurane suppresses colorectal cancer malignancy by modulating beta-catenin ubiquitination degradation via circSKA3.	hsa_circ_0000467	circSKA3 	hsa_circ_SKA3	SKA3	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circSKA3 is an upregulated oncogenic circRNA in CRC, and high expression is associated with poorer overall survival and advanced clinicopathological features. Mechanistically, circSKA3 binds beta-catenin, inhibits its destruction complex-mediated ubiquitinated degradation, activates Wnt/beta-catenin signaling, and promotes malignant CRC phenotypes; sevoflurane suppresses CRC partly by reducing circSKA3."	0.8961
38029946	Cellular signalling	2024	Sevoflurane suppresses colorectal cancer malignancy by modulating beta-catenin ubiquitination degradation via circSKA3.	hsa_circ_0000512				colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000512 was detected in the intersecting GEO datasets and validated by RT-qPCR as upregulated in CRC tissues. The study did not further characterize its clinical significance, interaction partners, subcellular localization, or functional mechanism."	0.4032
38031269	Protein and peptide letters	2023	The Role of circRNA-miRNA-mRNA Regulatory Network and its Potential Biomarker Function in Colorectal Cancer.	hsa_circ_0001573	circRNA_0001573 			colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001573 is upregulated in colorectal cancer tissues and CRC cell lines, with expression verified by qRT-PCR and resistance to RNase R digestion. The study proposes a circRNA_0001573/miR-382-5p/FZD3 regulatory axis as a potential mechanism related to CRC progression and suggests circRNA_0001573 as a potential diagnostic and progression biomarker."	0.5135
38032493	Naunyn-Schmiedeberg's archives of pharmacology	2024	Circ_0005015 upregulates BACH1 to promote aggressive behaviors in glioblastoma by sponging microRNA-382-5p.	hsa_circ_0005015	Circ_0005015	hsa_circ_HAS2	HAS2	glioblastoma 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; Microarray	"circ_0005015 is up-regulated in GBM tissues and cells and functions as an oncogenic circRNA. It promotes GBM proliferation, migration, invasion, glycolysis, and xenograft tumor growth while inhibiting apoptosis through the circ_0005015/miR-382-5p/BACH1 axis. The study suggests circ_0005015 may be a potential therapeutic target or biomarker for GBM."	0.8443
38037531	Journal of gastroenterology and hepatology	2024	CircTMEM87A promotes the tumorigenesis of gastric cancer by regulating the miR-1276/SLC7A11 axis.		circTMEM87A	hsa_circ_TMEM87A	TMEM87A	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circTMEM87A is upregulated in gastric cancer tissues and cell lines. It promotes malignant GC phenotypes by sponging miR-1276 and increasing SLC7A11 expression, leading to enhanced proliferation, migration, EMT and tumor growth, while suppressing apoptosis and ferroptosis. Its expression is associated with clinicopathologic features including differentiation, tumor size, TNM stage and lymph node metastasis."	0.8299
38040194	Journal of proteomics	2024	SRSF1 inhibits ferroptosis and reduces cisplatin chemosensitivity of triple-negative breast cancer cells through the circSEPT9/GCH1 axis.		circular RNA septin 9 	hsa_circ_SEPT9	SEPT9	triple negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"In TNBC cells, circSEPT9 is upregulated, especially in DDP-resistant cells. SRSF1 binds and promotes circSEPT9, while circSEPT9 binds GCH1 and blocks its ubiquitination, stabilizing GCH1 protein. This circSEPT9/GCH1 mechanism inhibits ferroptosis and reduces cisplatin chemosensitivity."	0.7363
38041751	Journal of bioenergetics and biomembranes	2024	Circ_0002395 promotes aerobic glycolysis and proliferation in pancreatic adenocarcinoma cells via miR-548c-3p/PDK1 axis.	hsa_circ_0002395	circ_0002395	hsa_circ_TRAPPC6B	TRAPPC6B	pancreatic adenocarcinoma 	MONDO:0006047	pancreatic adenocarcinoma	up-regulated	RT-qPCR	"hsa_circ_0002395/circ_0002395 is up-regulated in PAAD tissues and cell lines and acts as an oncogenic circRNA. It promotes PAAD cell proliferation and aerobic glycolysis by sponging miR-548c-3p and increasing PDK1 expression, and its higher expression is associated with larger tumor size and lymph node metastasis."	0.779
38042362	Joint bone spine	2024	Circular RNA circ-3626 promotes bone formation by modulating the miR-338-3p/Runx2 axis.	hsa_circ_0003626		hsa_circ_STAG1	STAG1	senile osteoporosis 	MONDO:0005298	osteoporosis	down-regulated	RT-qPCR; RNA-seq	"circ-3626 is a STAG1-derived circRNA that is downregulated in osteoporosis bone tissues and positively correlated with bone density. It promotes osteogenic differentiation and bone formation by sponging miR-338-3p to increase Runx2 and osteogenic marker gene expression, suggesting therapeutic potential for senile osteoporosis-related bone loss."	0.7858
38048812	Laboratory medicine	2024	Diagnostic value of plasma circular RNA based on droplet digital polymerase chain reaction in lung adenocarcinoma.	hsa_circ_0000014	circle RNALZIC 	hsa_circ_LZIC	LZIC	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circLZIC is a human plasma circRNA derived from LZIC that is increased in lung adenocarcinoma and decreases after surgery. The study supports its potential as a diagnostic biomarker, especially for early lung adenocarcinoma, and predicts a circRNA-miRNA-mRNA mechanism with enrichment of downstream genes in the relaxin signaling pathway."	0.5047
38048812	Laboratory medicine	2024	Diagnostic value of plasma circular RNA based on droplet digital polymerase chain reaction in lung adenocarcinoma.	hsa_circ_0003942	circle RNACEP350 	hsa_circ_CEP350	CEP350	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circCEP350 is a human plasma circRNA derived from CEP350 that is increased in lung adenocarcinoma and decreases after surgery. The study supports its potential as a diagnostic biomarker and predicts a circRNA-miRNA-mRNA mechanism, with downstream genes enriched in Hippo signaling and apoptosis-related mitochondrial processes."	0.5047
38050963	Autophagy	2024	Circ-0000953 deficiency exacerbates podocyte injury and autophagy disorder by targeting Mir665-3p-Atg4b in diabetic nephropathy.	mmu_circ_0000953				diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	down-regulated	RT-qPCR; ISH; RNA-seq	"Circ -0,000,953/mmu_circ_0000953 is downregulated in diabetic nephropathy and in diabetic mouse kidneys, HG-stimulated podocytes, and DN patient renal biopsy samples. Its overexpression or podocyte conditional knockin protects against albuminuria, renal injury, podocyte damage, inflammation, and autophagy impairment, whereas knockdown worsens disease phenotypes. Mechanistically, it functions through the circ -0,000,953-Mir665-3p-Atg4b axis, and its downregulation is linked to METTL3-mediated m6A modification and YTHDF2-dependent degradation."	0.8803
38054576	International journal of experimental pathology	2024	Circular RNA circVAPA modulates macrophage pyroptosis in sepsis-induced acute lung injury through targeting miR-212-3p/Sirt1/Nrf2/NLRP3 axis.	hsa_circ_0006990	circVAPA	hsa_circ_VAPA	VAPA	Sepsis-induced acute lung injury 	MONDO:0005229	bacterial infectious disease with sepsis	down-regulated	RT-qPCR; ISH	"circVAPA is down-regulated in sepsis-induced ALI models and LPS-treated RAW264.7 macrophages. Its over-expression protects against lung inflammatory injury by sponging miR-212-3p to regulate Sirt1 and the Sirt1/Nrf2/NLRP3 pathway, thereby inhibiting macrophage pyroptosis and Th17-associated inflammatory responses."	0.6815
38055163	Molecular neurobiology	2024	CircTrim37 Ameliorates Intracerebral Hemorrhage Outcomes by Modulating Microglial Polarization via the miR-30c-5p/SOCS3 Axis.		mmu_circRNA_24012 	mmu_circ_Trim37	Trim37	intracerebral hemorrhage 	MONDO:0013792	intracerebral hemorrhage	up-regulated	RT-qPCR; Microarray	"This study identified circTrim37 as a mouse Trim37-derived circRNA significantly upregulated in brain tissue 3 days after intracerebral hemorrhage. circTrim37 acts protectively in ICH by sponging miR-30c-5p to increase SOCS3, promoting anti-inflammatory M2 microglial polarization while suppressing M1 polarization, inflammation, apoptosis, cerebral edema and neurological deficits. The authors propose circTrim37 as a potential therapeutic target for ICH."	0.7909
38058810	American journal of cancer research	2023	CircATP13A1 (hsa_circ_0000919) promotes cell proliferation and metastasis and inhibits cell apoptosis in pancreatic ductal adenocarcinoma via the miR-186/miR-326/HMGA2 axis: implications for novel therapeutic targets.	hsa_circ_0000919	CircATP13A1	hsa_circ_ATP13A1	ATP13A1	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circATP13A1 is upregulated in PDAC tissues and cell lines, and high expression is associated with poor survival. Functionally, it promotes proliferation, migration, invasion, colony formation and in vivo tumor growth while suppressing apoptosis. Mechanistically, circATP13A1 acts as an oncogenic ceRNA by sponging miR-186 and miR-326 to regulate HMGA2 in PDAC."	0.8818
38059880	Journal of gastroenterology and hepatology	2024	"Circ ubiquitin-like-containing plant homeodomain and RING finger domains protein 1 increases the stability of G9a and ubiquitin-like-containing plant homeodomain and RING finger domains protein 1 messenger RNA through recruiting eukaryotic translation initiation factor 4A3, transcriptionally inhibiting PDZ and homeobox protein domain protein 1, and promotes the metastasis of hepatocellular carcinoma."	hsa_circ_0048676	"Circular ubiquitin-like, containing PHD and ring finger domains 1 "	hsa_circ_UHRF1	UHRF1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circUHRF1 is up-regulated in human HCC tissues and cell lines, and high expression is associated with poor prognosis. Functionally, circUHRF1 promotes HCC proliferation, migration, invasion, EMT, and metastasis. Mechanistically, it recruits EIF4A3 to stabilize G9a and UHRF1 mRNAs, leading to PDLIM1 transcriptional inhibition and Hippo-YAP pathway activation."	0.9014
38062234	Molecular biotechnology	2024	Circ_0061140 Potentiates Clear Cell Renal Cell Carcinoma Progression Via the MicroRNA-126-5p/ADAM9 Axis.	hsa_circ_0061140	circ_0061140	hsa_circ_C20orf11	C20orf11	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR	"hsa_circ_0061140/circ_0061140 is upregulated in ccRCC tissues and cell lines, and high expression is associated with worse five-year survival. Functionally, circ_0061140 promotes ccRCC cell proliferation, migration and invasion while inhibiting apoptosis. Mechanistically, it acts as a cytoplasmic miR-126-5p sponge to increase ADAM9 expression, forming a circ_0061140/miR-126-5p/ADAM9 oncogenic axis."	0.8174
38062819	Frontiers in bioscience (Landmark edition)	2023	Unveiling Circular RNA-Mediated Regulatory Mechanisms in Necroptosis in Premature Ovarian Failure.		rno_circRNA_004995			premature ovarian failure 	MONDO:0005387	primary ovarian failure	dysregulated	RNA-seq	"rno_circRNA_004995 was included in a predicted necroptosis-related ceRNA network in POF rats. The proposed axis is rno_circRNA_004995/rno-miR-148b-5p/H2afy2, suggesting a potential role in regulating necroptosis-associated mRNA expression in POF."	0.5202
38062819	Frontiers in bioscience (Landmark edition)	2023	Unveiling Circular RNA-Mediated Regulatory Mechanisms in Necroptosis in Premature Ovarian Failure.		rno_circRNA_016998			premature ovarian failure 	MONDO:0005387	primary ovarian failure	dysregulated	RNA-seq	"rno_circRNA_016998 was included in a predicted necroptosis-related ceRNA network in POF rats. The proposed axis is rno_circRNA_016998/rno-miR-29a-5p/Hmgb1, suggesting a potential role in regulating necroptosis-associated mRNA expression in POF."	0.5202
38062819	Frontiers in bioscience (Landmark edition)	2023	Unveiling Circular RNA-Mediated Regulatory Mechanisms in Necroptosis in Premature Ovarian Failure.		rno_circRNA_017593			premature ovarian failure 	MONDO:0005387	primary ovarian failure	dysregulated	RNA-seq	"rno_circRNA_017593 was included in a predicted necroptosis-related ceRNA network in POF rats. The proposed axis is rno_circRNA_017593/rno-miR-29a-5p/Hmgb1, suggesting a potential role in regulating necroptosis-associated mRNA expression in POF."	0.5202
38062819	Frontiers in bioscience (Landmark edition)	2023	Unveiling Circular RNA-Mediated Regulatory Mechanisms in Necroptosis in Premature Ovarian Failure.		rno_circRNA_015900			premature ovarian failure 	MONDO:0005387	primary ovarian failure	dysregulated	RNA-seq	"rno_circRNA_015900 was included in a predicted necroptosis-related ceRNA network in POF rats. The proposed axis is rno_circRNA_015900/rno-miR-935/Stat1, suggesting a potential role in regulating necroptosis-associated mRNA expression in POF."	0.5202
38062819	Frontiers in bioscience (Landmark edition)	2023	Unveiling Circular RNA-Mediated Regulatory Mechanisms in Necroptosis in Premature Ovarian Failure.		rno_circRNA_007946			premature ovarian failure 	MONDO:0005387	primary ovarian failure	dysregulated	RNA-seq	"rno_circRNA_007946 was included in a predicted necroptosis-related ceRNA network in POF rats. The proposed axis is rno_circRNA_007946/rno-miR-328a-3p/Stat5a, suggesting a potential role in regulating necroptosis-associated mRNA expression in POF."	0.5202
38062819	Frontiers in bioscience (Landmark edition)	2023	Unveiling Circular RNA-Mediated Regulatory Mechanisms in Necroptosis in Premature Ovarian Failure.		rno_circRNA_007947			premature ovarian failure 	MONDO:0005387	primary ovarian failure	dysregulated	RNA-seq	"rno_circRNA_007947 was included in a predicted necroptosis-related ceRNA network in POF rats. The proposed axis is rno_circRNA_007947/rno-miR-328a-3p/Stat5a, suggesting a potential role in regulating necroptosis-associated mRNA expression in POF."	0.5202
38062819	Frontiers in bioscience (Landmark edition)	2023	Unveiling Circular RNA-Mediated Regulatory Mechanisms in Necroptosis in Premature Ovarian Failure.		rno_circRNA_005064			premature ovarian failure 	MONDO:0005387	primary ovarian failure	dysregulated	RNA-seq	"rno_circRNA_005064 was included in a predicted necroptosis-related ceRNA network in POF rats. It was linked to rno-miR-18a-5p and the necroptosis-related mRNAs Stat1 and Stat5a, suggesting a potential role in regulating necroptosis-associated gene expression in POF."	0.5202
38062819	Frontiers in bioscience (Landmark edition)	2023	Unveiling Circular RNA-Mediated Regulatory Mechanisms in Necroptosis in Premature Ovarian Failure.		rno_circRNA_005115			premature ovarian failure 	MONDO:0005387	primary ovarian failure	dysregulated	RNA-seq	"rno_circRNA_005115 was included in a predicted necroptosis-related ceRNA network in POF rats. The proposed axis is rno_circRNA_005115/rno-miR-22-3p/Stat1, suggesting a potential role in regulating necroptosis-associated mRNA expression in POF."	0.5202
38062819	Frontiers in bioscience (Landmark edition)	2023	Unveiling Circular RNA-Mediated Regulatory Mechanisms in Necroptosis in Premature Ovarian Failure.		rno_circRNA_009028			premature ovarian failure 	MONDO:0005387	primary ovarian failure	dysregulated	RNA-seq	"rno_circRNA_009028 was included in a predicted necroptosis-related ceRNA network in POF rats. The proposed axis is rno_circRNA_009028/rno-miR-342-5p/Stat1, suggesting a potential role in regulating necroptosis-associated mRNA expression in POF."	0.5202
38062819	Frontiers in bioscience (Landmark edition)	2023	Unveiling Circular RNA-Mediated Regulatory Mechanisms in Necroptosis in Premature Ovarian Failure.		rno_circRNA_011240			premature ovarian failure 	MONDO:0005387	primary ovarian failure	dysregulated	RNA-seq	"rno_circRNA_011240 was included in a predicted necroptosis-related ceRNA network in POF rats. The proposed axis is rno_circRNA_011240/rno-miR-1224/Stat5a, suggesting a potential role in regulating necroptosis-associated mRNA expression in POF."	0.5202
38062819	Frontiers in bioscience (Landmark edition)	2023	Unveiling Circular RNA-Mediated Regulatory Mechanisms in Necroptosis in Premature Ovarian Failure.		rno_circRNA_016078			premature ovarian failure 	MONDO:0005387	primary ovarian failure	dysregulated	RNA-seq	"rno_circRNA_016078 was included in a predicted necroptosis-related ceRNA network in POF rats. The proposed axis is rno_circRNA_016078/rno-miR-711/Stat5a, suggesting a potential role in regulating necroptosis-associated mRNA expression in POF."	0.5202
38063095	"Cellular and molecular biology (Noisy-le-Grand, France)"	2023	CircBCAR3 sponges miR-27a-3p and mediates ferroptosis in human B-prolymphocytic leukaemia cells via SLC7A11.		circBCAR3 	hsa_circ_BCAR3	BCAR3	B-prolymphocytic leukaemia 	MONDO:0019461	B-cell prolymphocytic leukemia	up-regulated	RT-qPCR	"CircBCAR3 is up-regulated in the human B-prolymphocytic leukaemia cell line JVM-2 compared with normal B lymphocytes. It acts as a sponge for miR-27a-3p and positively regulates SLC7A11, thereby inhibiting ferroptosis and peroxidative damage while promoting B-PLL cell survival."	0.5607
38063110	"Cellular and molecular biology (Noisy-le-Grand, France)"	2023	Circular RNA EFR3A promotes nasopharyngeal carcinoma progression through modulating the miR-654-3p/EFR3A axis.	hsa_circ_0135761	circEFR3A 	hsa_circ_EFR3A	EFR3A	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"circEFR3A is up-regulated in nasopharyngeal carcinoma cells and acts as an oncogenic circRNA. It promotes proliferation, migration, and in vivo tumor growth while inhibiting apoptosis through a ceRNA mechanism in which it sponges miR-654-3p to increase EFR3A expression."	0.8279
38065380	Clinica chimica acta; international journal of clinical chemistry	2024	Plasma circRNA HIPK2 as a putative biomarker for the diagnosis and prediction of therapeutic effects in major depressive disorder.	hsa_circ_0001756	circular RNA HIPK2 	hsa_circ_HIPK2	HIPK2	major depressive disorder 	MONDO:0002009	major depressive disorder	up-regulated	RT-qPCR	"The study reports that plasma circHIPK2/hsa_circ_0001756 is up-regulated in patients with major depressive disorder and correlates with several depression-related neuropsychological scores. It is proposed as a blood-based biomarker for MDD diagnosis and for predicting response to 14-day antidepressive treatment, while bioinformatics analyses suggest potential ceRNA, RBP-interaction, and host-gene-related mechanisms."	0.6023
38071034	Zhongguo shi yan xue ye xue za zhi	2023	"[Effects of circ-SFMBT2 on Proliferation, Migration and Invasion of Acute Myeloid Leukemia Cells by Regulating miR-491-5p/HOXA9 Axis]."		circ-SFMBT2	hsa_circ_SFMBT2		acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"circ-SFMBT2 is up-regulated in pediatric AML bone marrow samples and AML cell lines, and high expression is associated with poor overall survival. Functionally, circ-SFMBT2 promotes AML cell proliferation, migration and invasion and suppresses apoptosis, at least partly by sponging miR-491-5p and regulating HOXA9."	0.7962
38072304	Experimental cell research	2024	Silencing hsa_circ_0032449 inhibits the pancreatic differentiation of human embryonic stem cells via the hsa_miR-195-5p/CCND1/PI3K/AKT signaling pathway.	hsa_circ_0032449	hsa_circRNA_0032449 	hsa_circ_PCNX1	PCNX1	type 1 diabetes 	MONDO:0005147	type 1 diabetes mellitus	unknown	RT-qPCR; ISH; RNA-seq	"This study identified hsa_circ_0032449 as a human circRNA enriched during pancreatic progenitor specification from hESC-derived PFG cells. hsa_circ_0032449 promotes PP cell differentiation, proliferation, SC-beta-cell maturation and insulin-secretory function through a cytoplasmic ceRNA mechanism involving miR-195-5p, CCND1 and PI3K/AKT signaling; its knockdown impaired SC-beta-cell function and failed to improve hyperglycemia in STZ-induced diabetic nude mice."	0.6256
38072968	Cancer gene therapy	2024	Circular RNA RHBDD1 regulates tumorigenicity and ferroptosis in colorectal cancer by mediating the ELAVL1/SCD mRNA interaction.	hsa_circ_0058495	circRHBDD1 	hsa_circ_RHBDD1	RHBDD1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circRHBDD1 is a human RHBDD1-derived circRNA that is upregulated in colorectal cancer tissues, serum and cell lines. It promotes CRC proliferation, migration and xenograft tumorigenicity while repressing ferroptosis by scaffolding ELAVL1 and SCD mRNA to enhance SCD mRNA stability and SCD expression. Its serum expression is associated with CRC progression and liver metastasis and shows diagnostic potential."	0.8812
38079004	Applied biochemistry and biotechnology	2024	circ-ATAD1 as Competing Endogenous RNA for miR-191-5p Forces Non-small Cell Lung Cancer Progression.		circ-ATAD1 	hsa_circ_ATAD1	ATAD1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ-ATAD1 is up-regulated in NSCLC tissues and cells and its high expression is associated with advanced disease features and poor survival. Functionally, it promotes proliferation, migration, invasion, growth and metastasis of NSCLC cells while suppressing apoptosis. Mechanistically, circ-ATAD1 acts as a ceRNA for miR-191-5p to increase FOXK1 expression."	0.7759
38081601	Nan fang yi ke da xue xue bao = Journal of Southern Medical University	2023	[Circular RNA hsa_circ_0006834 is a potential prognostic biomarker for hepatocellular carcinoma].	hsa_circ_0006834		hsa_circ_EPB41L5	EPB41L5	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0006834 is significantly down-regulated in HCC tissues compared with adjacent tissues. Its lower expression is associated with vascular invasion, BCLC stage, and worse recurrence-free and overall survival, supporting its role as a potential prognostic biomarker for HCC."	0.7034
38081797	The journal of obstetrics and gynaecology research	2024	Suppression of circular RNA serum and glucocorticoid-induced kinase 1 elevates antioxidant molecules and angiogenesis in trophoblast cells to attenuate preeclampsia via microRNA-508-3p to target and restrain PUM homolog 1.		circRNA serum and glucocorticoid-induced kinase 1 (SGK1) 	hsa_circ_SGK1	SGK1	Preeclampsia 	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR	"circSGK1 is up-regulated in placental tissues from patients with preeclampsia. Functionally, circSGK1 appears to aggravate PE-related trophoblast dysfunction, because its silencing promotes trophoblast proliferation, migration, invasion, antioxidant defense and angiogenesis while reducing apoptosis. Mechanistically, circSGK1 acts through the miR-508-3p/PUM1 axis."	0.7183
38084627	Journal of biochemical and molecular toxicology	2024	Circ-SATB2 (hsa_circ_0008928) and miR-150-5p are regulators of TRIM66 in the regulation of NSCLC cell growth and metastasis of NSCLC cells via the ceRNA pathway.	hsa_circ_0008928	Circ-SATB2 	hsa_circ_SATB2	SATB2	nonsmall cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"CircSATB2/hsa_circ_0008928 is up-regulated in NSCLC tissues and cell lines. It promotes NSCLC cell growth, migration, invasion, EMT-related marker changes, and xenograft tumor growth while inhibiting apoptosis. Mechanistically, circSATB2 functions as a ceRNA for miR-150-5p, relieving miR-150-5p-mediated repression of TRIM66."	0.8175
38091240	Metabolic brain disease	2024	Circ_0027446 promotes malignant development of glioblastoma by interacting with miR-346 to up-regulate PGK1.	hsa_circ_0027446	Circ_0027446			glioblastoma 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR	"Circ_0027446 is up-regulated in GBM tissues and cells and acts as an oncogenic circRNA. Its knockdown suppresses proliferation, invasion, glycolytic metabolism and xenograft tumor growth while promoting apoptosis. Mechanistically, circ_0027446 sponges miR-346 to up-regulate PGK1, forming a circ_0027446/miR-346/PGK1 axis with potential diagnostic relevance in GBM."	0.7892
38091827	International immunopharmacology	2024	CircMAPK1 promoted CD8 + T cell infiltration in LUAD by improving the IGF2BP1 dependent CCL5 upregulation.	hsa_circ_0008870	circMAPK1 	hsa_circ_MAPK1	MAPK1	Lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; RNA-seq	"CircMAPK1 is down-regulated in LUAD and acts as an anti-tumor microenvironment-associated circRNA. It binds IGF2BP1 in the cytoplasm, promotes IGF2BP1-dependent stabilization of CCL5 mRNA, increases CCL5 expression, and thereby enhances CD8 + T cell recruitment/infiltration. The study suggests circMAPK1 may be a nucleic acid drug candidate to improve ICB immunotherapy response."	0.8658
38091827	International immunopharmacology	2024	CircMAPK1 promoted CD8 + T cell infiltration in LUAD by improving the IGF2BP1 dependent CCL5 upregulation.	mmu_circ_0006095	circMAPK1 	mmu_circ_MAPK1	MAPK1	Lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; RNA-seq	"CircMAPK1 is down-regulated in LUAD and acts as an anti-tumor microenvironment-associated circRNA. It binds IGF2BP1 in the cytoplasm, promotes IGF2BP1-dependent stabilization of CCL5 mRNA, increases CCL5 expression, and thereby enhances CD8 + T cell recruitment/infiltration. The study suggests circMAPK1 may be a nucleic acid drug candidate to improve ICB immunotherapy response."	0.8658
38091882	"Pathology, research and practice"	2024	m6A-modified circ_0124554 promotes colorectal cancer progression and radioresistance through the miR-1184/LASP1 pathway.	hsa_circ_0124554	circ_0124554	hsa_circ_FOXP1	FOXP1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0124554 is upregulated in colorectal cancer tissues and cells. It promotes CRC proliferation, migration, invasion, tumor growth and radioresistance while suppressing apoptosis. Mechanistically, METTL3-mediated m6A modification increases circ_0124554, which acts through the miR-1184/LASP1 axis to drive malignant phenotypes and resistance to radiation."	0.8005
38093017	Nature	2024	Tumour circular RNAs elicit anti-tumour immunity by encoding cryptic peptides.		circFAM53B	hsa_circ_FAM53B	FAM53B	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Northern Blot; ISH; RNA-seq	"Human circFAM53B is a tumour-specific circRNA derived from FAM53B that encodes cryptic antigenic peptides presented by HLA molecules. These peptides activate antigen-specific CD4+ and CD8+ T-cell responses, suppress tumour growth in breast cancer PDX models, and high circFAM53B/circFAM53B-219 expression is linked to better prognosis in breast cancer and melanoma."	0.8541
38093017	Nature	2024	Tumour circular RNAs elicit anti-tumour immunity by encoding cryptic peptides.		circFam53b 	mmu_circ_Fam53b	Fam53b	mouse melanoma 	MONDO:0005105	melanoma	up-regulated	RT-qPCR; ISH; RNA-seq	Mouse circFam53b is upregulated in B16F10 melanoma cells and encodes MHC-binding cryptic antigenic peptides. Vaccination with circFam53b RNA or circFam53b-derived peptides induces antigen-specific cytotoxic T cells and inhibits melanoma tumour growth.	0.6887
38093017	Nature	2024	Tumour circular RNAs elicit anti-tumour immunity by encoding cryptic peptides.		circGigyf2 	mmu_circ_Gigyf2	Gigyf2	mouse breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"Mouse circGigyf2 is a cytoplasmic tumour-specific circRNA abundantly expressed in 4T1 breast cancer cells. It encodes cryptic antigenic peptides that generate antigen-specific T-cell responses, and circGigyf2 peptide or RNA vaccination reduces 4T1 tumour growth and lung metastases."	0.6181
38098469	Journal of geriatric cardiology : JGC	2023	Circulating circRNA expression profile and its potential role in late recurrence of paroxysmal atrial fibrillation post catheter ablation.	hsa_circ_0002665				late recurrence of atrial fibrillation 	MONDO:0004981	atrial fibrillation	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0002665 is up-regulated in peripheral blood from LRAF patients after PVI and was validated by qRT-PCR. The study predicts that it may act as a ceRNA for miR-103a and miR-107 and may be implicated in TCF25 regulation, suggesting potential biomarker or therapeutic relevance."	0.4685
38098469	Journal of geriatric cardiology : JGC	2023	Circulating circRNA expression profile and its potential role in late recurrence of paroxysmal atrial fibrillation post catheter ablation.	hsa_circ_0001953				late recurrence of atrial fibrillation 	MONDO:0004981	atrial fibrillation	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001953 is up-regulated in peripheral blood from LRAF patients after PVI and was validated by qRT-PCR. It was included among five validated differentially expressed circRNAs used to construct a predicted circRNA/miRNA interaction network, suggesting a possible regulatory role and biomarker potential."	0.4685
38098469	Journal of geriatric cardiology : JGC	2023	Circulating circRNA expression profile and its potential role in late recurrence of paroxysmal atrial fibrillation post catheter ablation.	hsa_circ_0003831				late recurrence of atrial fibrillation 	MONDO:0004981	atrial fibrillation	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0003831 is up-regulated in peripheral blood from LRAF patients after PVI and was validated by qRT-PCR. It was included in the predicted circRNA/miRNA interaction network of five validated DE circRNAs, supporting a possible regulatory role in LRAF."	0.4685
38098469	Journal of geriatric cardiology : JGC	2023	Circulating circRNA expression profile and its potential role in late recurrence of paroxysmal atrial fibrillation post catheter ablation.	hsa_circ_0040533				late recurrence of atrial fibrillation 	MONDO:0004981	atrial fibrillation	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0040533 is up-regulated in peripheral blood from LRAF patients after PVI and was validated by qRT-PCR. The study predicts that it may act as a ceRNA for miR-320d, supporting a possible role in AF-related pathophysiology and LRAF biomarker development."	0.4685
38098469	Journal of geriatric cardiology : JGC	2023	Circulating circRNA expression profile and its potential role in late recurrence of paroxysmal atrial fibrillation post catheter ablation.	hsa_circ_0041103				late recurrence of atrial fibrillation 	MONDO:0004981	atrial fibrillation	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0041103 is down-regulated in peripheral blood from LRAF patients after PVI and was validated by qRT-PCR. The study discusses a possible miRNA-107/FOXK1 axis and suggests that this circRNA may contribute to regulatory mechanisms underlying LRAF, although the detailed mechanism requires further study."	0.4685
38105623	The FEBS journal	2024	Circular RNA-circLRP6 protects cardiomyocyte from hypoxia-induced apoptosis by facilitating hnRNPM-mediated expression of FGF-9.		circLRP6 2-2 	hsa_circ_LRP6	LRP6	coronary heart disease 	MONDO:0005010	coronary artery disorder	down-regulated	RT-qPCR	"circLRP6 2-2 is a conserved cardiac circRNA derived from the second exon of LRP6 and is down-regulated in myocardial ischemia and hypoxic cardiomyocytes. It protects cardiomyocytes from hypoxia-induced apoptosis by interacting with hnRNPM, translocating into the cytoplasm under hypoxia, and promoting hnRNPM-mediated FGF9 protein expression through FGF9 mRNA recruitment. The study suggests the circLRP6 2-2/hnRNPM/FGF9 pathway as a potential therapeutic target for coronary heart disease and ischemic myocardial injury."	0.7909
38105623	The FEBS journal	2024	Circular RNA-circLRP6 protects cardiomyocyte from hypoxia-induced apoptosis by facilitating hnRNPM-mediated expression of FGF-9.		circLRP6 2-2 	mmu_circ_LRP6	LRP6	coronary heart disease 	MONDO:0005010	coronary artery disorder	down-regulated	RT-qPCR	"circLRP6 2-2 is a conserved cardiac circRNA derived from the second exon of LRP6 and is down-regulated in myocardial ischemia and hypoxic cardiomyocytes. It protects cardiomyocytes from hypoxia-induced apoptosis by interacting with hnRNPM, translocating into the cytoplasm under hypoxia, and promoting hnRNPM-mediated FGF9 protein expression through FGF9 mRNA recruitment. The study suggests the circLRP6 2-2/hnRNPM/FGF9 pathway as a potential therapeutic target for coronary heart disease and ischemic myocardial injury."	0.7909
38105623	The FEBS journal	2024	Circular RNA-circLRP6 protects cardiomyocyte from hypoxia-induced apoptosis by facilitating hnRNPM-mediated expression of FGF-9.		circLRP6 2-2 	rno_circ_LRP6	LRP6	coronary heart disease 	MONDO:0005010	coronary artery disorder	down-regulated	RT-qPCR	"circLRP6 2-2 is a conserved cardiac circRNA derived from the second exon of LRP6 and is down-regulated in myocardial ischemia and hypoxic cardiomyocytes. It protects cardiomyocytes from hypoxia-induced apoptosis by interacting with hnRNPM, translocating into the cytoplasm under hypoxia, and promoting hnRNPM-mediated FGF9 protein expression through FGF9 mRNA recruitment. The study suggests the circLRP6 2-2/hnRNPM/FGF9 pathway as a potential therapeutic target for coronary heart disease and ischemic myocardial injury."	0.7909
38113974	Genomics	2024	CircPHKB decreases the sensitivity of liver cancer cells to sorafenib via miR-1234-3p/CYP2W1 axis.	hsa_circ_0004791	circPHKB	hsa_circ_PHKB	PHKB	liver cancer 	MONDO:0002691	liver cancer	up-regulated	RT-qPCR; RNA-seq	"circPHKB is a PHKB-derived human circRNA that is up-regulated in sorafenib-treated liver cancer cells. It decreases sorafenib sensitivity by sponging miR-1234-3p and increasing CYP2W1 expression, thereby promoting survival/proliferation and inhibiting sorafenib-induced apoptosis; its knockdown sensitizes xenograft tumors to sorafenib."	0.8177
38113974	Genomics	2024	CircPHKB decreases the sensitivity of liver cancer cells to sorafenib via miR-1234-3p/CYP2W1 axis.	hsa_circ_0079812	circBBS9	hsa_circ_BBS9	BBS9	liver cancer 	MONDO:0002691	liver cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0079812 (circBBS9) was identified by transcriptome sequencing as one of three notably highly expressed circRNAs in sorafenib-treated liver cancer cells and was confirmed by qPCR. The article did not further investigate its mechanism, function, localization, or clinical significance."	0.1904
38113974	Genomics	2024	CircPHKB decreases the sensitivity of liver cancer cells to sorafenib via miR-1234-3p/CYP2W1 axis.		hsa_-circ_0000139 	hsa_circ_GON4L	GON4L	liver cancer 	MONDO:0002691	liver cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_-circ_0000139 (circGON4L) was identified by transcriptome sequencing as one of three notably highly expressed circRNAs in sorafenib-treated liver cancer cells and was confirmed by qPCR. The article did not further investigate its mechanism, function, localization, or clinical significance."	0.1904
38116839	The Analyst	2024	A DNA octahedral amplifier for endogenous circRNA detection and bioimaging in living cells and its biomarker study.		circHIPK3	hsa_circ_HIPK3	HIPK3	idiopathic pulmonary fibrosis 	MONDO:0800504	idiopathic pulmonary fibrosis	up-regulated	RT-qPCR	"This study used circHIPK3 as an IPF-related target circRNA and developed a DOA nanoprobe for in situ FRET detection and live-cell bioimaging. circHIPK3 was significantly upregulated in TGF-beta1-treated A549 pulmonary fibrosis cell models, supporting its potential as a biomarker for IPF-related diseases."	0.2586
38118330	Ecotoxicology and environmental safety	2024	Mechanistic insights into aniline-induced liver injury: Role of the mmu_circ_26984/Myh9/NLRP3 axis and modulation by N-acetylcysteine.		mmu_circ_26984 	mmu_circ_Dhx29	Dhx29	aniline-induced liver injury 	MONDO:0005359	drug-induced liver injury	up-regulated	RT-qPCR; ISH; Microarray	"mmu_circ_26984 is up-regulated in aniline-induced liver injury in mouse liver tissue and AML12 cells. It promotes inflammatory liver damage by interacting with the RNA-binding protein Myh9 and increasing Myh9/NLRP3-related inflammatory factor expression, while NAC attenuates this injury pathway."	0.8351
38118330	Ecotoxicology and environmental safety	2024	Mechanistic insights into aniline-induced liver injury: Role of the mmu_circ_26984/Myh9/NLRP3 axis and modulation by N-acetylcysteine.	hsa_circ_0001483				aniline-induced liver injury 	MONDO:0005359	drug-induced liver injury	dysregulated	RT-qPCR	"hsa_circ_0001483 was examined as the human homologous circRNA of mmu_circ_26984 in aniline-treated L02 hepatocytes. The study reports RT-qPCR-based differential expression, supporting its possible translational relevance, but does not define a mechanistic role for hsa_circ_0001483."	0.1155
38123043	Cellular signalling	2024	The circular RNA expression profile of human auricle cartilage and the role of circCOL1A2 in isolated microtia.		circCOL1A2 	hsa_circ_COL1A2	COL1A2	isolated microtia 	MONDO:0010920	microtia	up-regulated	RT-qPCR; Microarray	"circCOL1A2 is upregulated in auricle cartilage from patients with isolated microtia and was selected as the key representative circRNA for functional study. It is mainly cytoplasmic and acts through a circCOL1A2/miR-637/DSEL ceRNA axis to increase DSEL expression, thereby inhibiting chondrocyte proliferation and chondrogenic differentiation and contributing to auricle cartilage damage in isolated microtia."	0.7566
38124441	Environmental toxicology	2024	"CircTAOK1 regulates high glucose induced inflammation, oxidative stress, ECM accumulation, and apoptosis in diabetic nephropathy via targeting miR-142-3p/SOX6 axis."	hsa_circ_0003928	CircTAOK1 	hsa_circ_TAOK1	TAOK1	diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"CircTAOK1 is up-regulated in DN serum and high glucose-treated HK-2 cells. Functionally, circTAOK1 promotes high glucose-induced tubular epithelial cell injury, including apoptosis, inflammation, oxidative stress and ECM accumulation, while its knockdown is protective. Mechanistically, circTAOK1 functions through the miR-142-3p/SOX6 axis."	0.8275
38127107	Pediatric surgery international	2023	Circular RNA MTCL1 targets SMAD3 by sponging miR-145-5p for regulation of cell proliferation and migration in Hirschsprung's disease.	hsa_circ_0000825	Circ-MTCL1 	hsa_circ_MTCL1	MTCL1	Hirschsprung's disease 	MONDO:0018309	Hirschsprung disease	down-regulated	RT-qPCR	"Circ-MTCL1 is down-regulated in HSCR diseased segment colon tissues. Functional assays indicate that Circ-MTCL1 supports migration and proliferation of SH-SY5Y and 293T cells, while knockdown suppresses these processes. Mechanistically, Circ-MTCL1 sponges miR-145-5p to regulate SMAD3 expression, suggesting a Circ-MTCL1/miR-145-5p/SMAD3 axis relevant to HSCR development and potential diagnosis."	0.778
38127171	Biochemical genetics	2024	CircSFMBT2 Plays an Oncogenic Role in Lung Adenocarcinoma Depending on the miR-1305/SALL4 Axis.	hsa_circ_0017639	circRNA scm like with four mbt domains 2 	hsa_circ_SFMBT2	SFMBT2	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"CircSFMBT2 is an upregulated oncogenic circRNA in LUAD and high expression is associated with advanced TNM stage and poorer overall survival. Functionally, it promotes proliferation, migration, invasion, glycolysis and xenograft tumor growth while inhibiting apoptosis. Mechanistically, circSFMBT2 sponges miR-1305 to increase SALL4 expression, forming a circSFMBT2/miR-1305/SALL4 regulatory axis."	0.7976
38128869	European journal of pharmacology	2024	circNFIB decreases synthesis of arachidonic acid and inhibits breast tumor growth and metastasis.	hsa_circ_0086376	circNFIB 	hsa_circ_NFIB	NFIB	breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; RNA-seq	"circNFIB (hsa_circ_0086376), derived from NFIB, is down-regulated in breast cancer tissues and cells and functions as a tumor suppressor. It inhibits breast cancer proliferation, invasion, tumor growth, and metastasis, potentially through protein-coding capacity and suppression of arachidonic acid synthesis via phospholipase regulation. EIF4A3 and U2AF65 are proposed upstream regulators of circNFIB expression."	0.8109
38129720	Biochemical genetics	2024	Circ-NUP98 Promotes Lung Adenocarcinoma Development Through Regulating CBX1 by miR-188-3p.		circ-NUP98	hsa_circ_NUP98	NUP98	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"circ-NUP98 is up-regulated in LUAD tissues and cell lines and functions as an oncogenic circRNA. Silencing circ-NUP98 suppresses proliferation, migration, invasion, cell-cycle progression, oxidative stress, and xenograft tumor growth while promoting apoptosis. Mechanistically, circ-NUP98 sponges miR-188-3p to relieve repression of CBX1, forming a circ-NUP98/miR-188-3p/CBX1 regulatory axis."	0.8175
38129937	Microbiology and immunology	2024	Circ_0008410 contributes to fibroblast-like synoviocytes dysfunction by regulating miR-149-5p/HIPK2 axis.	hsa_circ_0008410	circ_0008410	hsa_circ_PGS1	PGS1	rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"circ_0008410 is up-regulated in RA synovial tissues and RASFs. It promotes RASF proliferation, migration, invasion, and inflammatory cytokine production while suppressing apoptosis. Mechanistically, circ_0008410 acts through the miR-149-5p/HIPK2 axis and may represent a therapeutic target for rheumatoid arthritis."	0.8278
38141006	Advances in clinical and experimental medicine : official organ Wroclaw Medical University	2024	Endogenous hsa-circ_0007113 binds hsa-miR-515-5p to regulate senescence in human embryonic lung fibroblasts.	hsa_circ_0007113		hsa_circ_HERC4	HERC4	cellular senescence 			down-regulated	RT-qPCR; Microarray	"hsa_circ_0007113 is downregulated in senescent IMR-90 cells and in older individuals. Functional inhibition of hsa_circ_0007113 promotes senescence, likely through a miR-515-5p/p53-p21-related ceRNA mechanism."	0.6221
38141413	International immunopharmacology	2024	Hsa_circ_0105040 promotes Cutbacterium acnes biofilm induced inflammation via sponge miR-146a in human keratinocyte.	hsa_circ_0105040		hsa_circ_FLNA	FLNA	acne 	MONDO:0011438	acne	down-regulated	RT-qPCR; ISH; Microarray	"This study identifies hsa_circ_0105040 as a down-regulated FLNA-derived circRNA in acne tissues that is predominantly localized in the cytoplasm of human primary keratinocytes. Functionally, hsa_circ_0105040 promotes C. acnes biofilm-induced inflammation by sponging miR-146a, thereby increasing IRAK1/TRAF6 expression and activating MAPK and NF-kappaB-related inflammatory responses. The authors propose this hsa_circ_0105040/miR-146a/IRAK1/TRAF6 axis as a potential therapeutic target or marker for inflammatory acne."	0.8304
38141793	Cellular signalling	2024	A comprehensive evaluation of circ_0065214/ miR-188-3p/GPNMB axis in breast cancer.	hsa_circ_0065214	circ_0065214	hsa_circ_SCAP	SCAP	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circ_0065214 is an SCAP-derived human circRNA up-regulated in breast cancer tissues, serum and cell lines. It promotes breast cancer proliferation, migration, invasion and tumor growth while inhibiting autophagy through a circ_0065214/miR-188-3p/GPNMB ceRNA axis. Serum circ_0065214 also shows diagnostic potential for breast cancer, especially when combined with CEA and CA-153."	0.8585
38142763	Experimental eye research	2024	Circular RNA expression profile identifies potential circulating biomarkers for keratoconus.	hsa_circ_0001946	circ_0001946			keratoconus 	MONDO:0015486	keratoconus	down-regulated	RT-qPCR; RNA-seq	"circ_0001946 was down-regulated in KC corneal tissues and validated by qRT-PCR after RNA-seq screening. The study suggests it is related to KC and may participate in disease pathogenesis, but no specific molecular mechanism was experimentally defined."	0.3588
38142763	Experimental eye research	2024	Circular RNA expression profile identifies potential circulating biomarkers for keratoconus.	hsa_circ_0006156	circ_0006156	hsa_circ_FNDC3B	FNDC3B	keratoconus 	MONDO:0015486	keratoconus	down-regulated	RT-qPCR; RNA-seq	"circ_0006156 was significantly down-regulated in both KC corneal tissue and peripheral blood. The study supports its potential as a circulating biomarker for KC diagnosis, but did not experimentally define a molecular mechanism."	0.4679
38142763	Experimental eye research	2024	Circular RNA expression profile identifies potential circulating biomarkers for keratoconus.	hsa_circ_0008513	circ_0008513			keratoconus 	MONDO:0015486	keratoconus	down-regulated	RT-qPCR; RNA-seq	"circ_0008513 was down-regulated in KC corneal tissues and validated by qRT-PCR. It is proposed as related to KC pathogenesis, but the study did not provide functional or mechanistic validation."	0.3588
38142763	Experimental eye research	2024	Circular RNA expression profile identifies potential circulating biomarkers for keratoconus.	hsa_circ_0006117	circ_0006117	hsa_circ_PTPRA	PTPRA	keratoconus 	MONDO:0015486	keratoconus	down-regulated	RT-qPCR; RNA-seq	"circ_0006117 was down-regulated in KC cornea and peripheral blood. Its blood expression showed diagnostic value and correlated with clinical parameters of KC severity, supporting its role as a circulating biomarker."	0.4679
38142763	Experimental eye research	2024	Circular RNA expression profile identifies potential circulating biomarkers for keratoconus.	hsa_circ_0001640	circ_0001640			keratoconus 	MONDO:0015486	keratoconus	down-regulated	RT-qPCR; RNA-seq	"circ_0001640 was down-regulated in KC corneal tissue and validated by qRT-PCR. The study proposes a relationship with KC pathogenesis, without defining a specific regulatory mechanism."	0.3588
38142763	Experimental eye research	2024	Circular RNA expression profile identifies potential circulating biomarkers for keratoconus.	hsa_circ_0005654	circ_0005654			keratoconus 	MONDO:0015486	keratoconus	down-regulated	RT-qPCR; RNA-seq	"circ_0005654 was significantly down-regulated in KC corneal tissues, but its decrease in peripheral blood was not statistically significant. It was included in ROC/logistic biomarker analyses, although the evidence for blood-based diagnostic relevance was weaker than for the four significant blood circRNAs."	0.4679
38142763	Experimental eye research	2024	Circular RNA expression profile identifies potential circulating biomarkers for keratoconus.	hsa_circ_0000284	circ_0000284	hsa_circ_HIPK3	HIPK3	keratoconus 	MONDO:0015486	keratoconus	down-regulated	RT-qPCR; RNA-seq	"circ_0000284 was down-regulated in KC cornea and peripheral blood, including in early, moderate, and advanced KC. It had the best diagnostic performance among the four significant blood circRNAs, supporting its potential as a circulating biomarker for KC."	0.4679
38142763	Experimental eye research	2024	Circular RNA expression profile identifies potential circulating biomarkers for keratoconus.	hsa_circ_0001801	circ_0001801 	hsa_circ_PCMTD1	PCMTD1	keratoconus 	MONDO:0015486	keratoconus	down-regulated	RT-qPCR; RNA-seq	"circ_0001801 was significantly down-regulated in KC cornea and peripheral blood and showed diagnostic value in ROC analysis. Its mean expression decreased with severity stages, but stage-related differences were not statistically significant."	0.4679
38147774	Ecotoxicology and environmental safety	2024	Mechanism through which the hsa-circ_0000992- hsa- miR- 936-AKT3 regulatory network promotes the PM2.5-induced inflammatory response in human bronchial epithelial cells.	hsa_circ_0000992	hsa-circ_0000992 			PM 2.5-induced inflammation 	MONDO:0043905	pneumonitis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000992 is up-regulated in PM 2.5-exposed human bronchial epithelial 16HBE cells. It promotes inflammatory responses by sponging hsa-miR-936, regulating AKT3, and activating the PI3K/AKT pathway, leading to increased IL-1beta and IL-8 expression."	0.6731
38147784	Journal of neuroimmunology	2024	YTHDF2 alleviates microglia activation via promoting circHIPK2 degradation.	mmu_circ_0001468	circHIPK2	mmu_circ_HIPK2	HIPK2	central nervous system inflammation 	MONDO:0005156	encephalomyelitis	up-regulated	RT-qPCR	"In LPS-induced mouse cortex inflammation and BV2 microglia activation models, circHIPK2 is up-regulated and is associated with microglial inflammatory activation. Knockdown of circHIPK2 suppresses iNOS, IL-1beta, IL-6, and BV2 cell proliferation, indicating a pro-inflammatory role. Mechanistically, the m6A reader/RBP YTHDF2 interacts with circHIPK2 and accelerates its degradation, thereby alleviating microglia activation."	0.6376
38151617	Molecular biotechnology	2024	"Circ_0000115 Protects Against Cerebral Ischemia Injury by Suppressing Neuronal Apoptosis, Oxidative Stress and Inflammation by miR-1224-5p/Nos3 Axis In Vitro."	mmu_circ_0000115	Circ_0000115 	mmu_circ_Uck2	Uck2	cerebral ischemia 	MONDO:0002679	cerebral infarction	down-regulated	RT-qPCR	"Circ_0000115 is a mouse Uck2-derived circRNA that is down-regulated in OGD-treated N2a and HT22 neuronal cells. Its overexpression protects cells from cerebral ischemia-like injury by promoting proliferation and suppressing apoptosis, oxidative stress, and inflammation. Mechanistically, the study supports a ceRNA axis in which circ_0000115 sponges miR-1244-5p to increase NOS3 expression, although the abstract/title inconsistently refer to miR-1224-5p."	0.7986
38153651	Applied biochemistry and biotechnology	2024	Berberine Protects Against Dihydrotestosterone-Induced Human Ovarian Granulosa Cell Injury and Ferroptosis by Regulating the Circ_0097636/MiR-186-5p/SIRT3 Pathway.	hsa_circ_0097636	circ_0097636			Polycystic ovarian syndrome 	MONDO:0008487	polycystic ovary syndrome	down-regulated	RT-qPCR	"circ_0097636 is downregulated in follicular fluid from PCOS patients and in DHT-induced KGN cells. Its overexpression protects granulosa cells from DHT-induced injury by promoting proliferation and suppressing apoptosis, inflammation, oxidative stress, and ferroptosis, acting through the miR-186-5p/SIRT3 pathway. BBR exerts part of its protective effect in this PCOS cell model by upregulating circ_0097636."	0.7795
38154610	Life sciences	2024	Citronellal can alleviate vascular endothelial dysfunction by reducing ectopic miR-133a expression.		circRNA_102979 	hsa_circ_RBCK1	RBCK1	vascular endothelial dysfunction 	MONDO:0005385	vascular disorder	unknown	RT-qPCR; ISH	"This study identifies circRNA_102979 as a key mediator of citronellal¡¯s protective effect against AS-induced endothelial dysfunction. Citronellal activates AP-2alpha to increase circRNA_102979 expression, and circRNA_102979 adsorbs miR-133a, thereby reducing ectopic miR-133a activity and alleviating vascular endothelial injury."	0.6046
38157408	The Journal of clinical endocrinology and metabolism	2024	Hsa_circRNA_405498 and hsa_circRNA_100033 Serve as Potential Biomarkers for Differential Diagnosis of Type 1 Diabetes.		hsa_circRNA_405498	hsa_circ_GCSH	GCSH	type 1 diabetes 	MONDO:0005147	type 1 diabetes mellitus	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_405498 was significantly downregulated in T1D and showed an incremental decrease across the diabetes spectrum from NGT to T2D/LADA to T1D. It was validated by RT-qPCR in clinical PBMC samples and contributed to logistic LASSO diagnostic models for distinguishing T1D from LADA, T2D, and controls."	0.5963
38157408	The Journal of clinical endocrinology and metabolism	2024	Hsa_circRNA_405498 and hsa_circRNA_100033 Serve as Potential Biomarkers for Differential Diagnosis of Type 1 Diabetes.		hsa_circRNA_100033	hsa_circ_RERE	RERE	type 1 diabetes 	MONDO:0005147	type 1 diabetes mellitus	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_100033 was significantly downregulated in T1D and showed an incremental decrease across the diabetes spectrum from NGT to T2D/LADA to T1D. It was validated by RT-qPCR in clinical PBMC samples and contributed to logistic LASSO diagnostic models, especially for distinguishing T1D from LADA and T2D."	0.5963
38159171	Molecular biotechnology	2024	Overexpression of circZNF720 Inhibits Hepatocellular Carcinoma Progression by Regulating miR-421/MAPK9.		circZNF720 	hsa_circ_ZNF720	ZNF720	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"circZNF720 is downregulated in HCC tissues and cell lines, and low expression is associated with worse prognosis. Functionally, circZNF720 overexpression suppresses HCC cell proliferation, migration and invasion while promoting apoptosis. Mechanistically, circZNF720 acts as a cytoplasmic ceRNA that sponges miR-421 and increases MAPK9 expression, thereby inhibiting HCC progression."	0.817
38163571	Genomics	2024	Identification of circular RNA-Dcaf6 as a therapeutic target for optic nerve crush-induced RGC degeneration.	mmu_circ_0008388	cDcaf6 	mmu_circ_Dcaf6	Dcaf6	optic nerve crush-induced RGC degeneration 	MONDO:0005328	eye disorder	up-regulated	RT-qPCR; Microarray	"cDcaf6/mmu_circ_0008388 is up-regulated in ONC-injured mouse retinas and in aqueous humor from glaucoma patients. Its silencing reduces oxidative stress-induced RGC apoptosis, decreases retinal reactive gliosis, alleviates ONC-induced retinal dysfunction and RGC degeneration, and EIF4A3 is identified as an upstream regulator interacting with cDcaf6."	0.7859
38164984	Journal of hypertension	2024	"Circ_0001861 facilitates trophoblast cell proliferation, migration, invasion and epithelial-mesenchymal transition via the miR-296-5p/forkhead box protein 1 pathway in preeclampsia."	hsa_circ_0001861	circ_0001861			Preeclampsia 	MONDO:0005081	preeclampsia	down-regulated	RT-qPCR	"circ_0001861 is down-regulated in PE placentas and placenta-associated serum exosomes. Functionally, circ_0001861 overexpression promotes trophoblast cell proliferation, migration, invasion and EMT. Mechanistically, it sponges miR-296-5p to upregulate FOXP1, forming a circ_0001861/miR-296-5p/FOXP1 axis with potential diagnostic and therapeutic relevance in PE."	0.8562
38168877	Oral diseases	2024	Circular RNA CircACAP2 regulates temporomandibular joint osteoarthritis via miR-21-5p/PLAG1 axis.		circRNA-ACAP2 	mmu_circ_ACAP2	ACAP2	temporomandibular joint osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR	"CircACAP2 is down-regulated in TMJOA cartilage and IL-1beta-induced chondrocytes. Its overexpression protects against TMJOA by sponging miR-21-5p, regulating PLAG1, promoting chondrocyte proliferation, reducing apoptosis, and inhibiting ECM catabolism. In vivo, AAV9-CircACAP2 injection alleviated UAC-induced TMJOA progression in mice."	0.5627
38178663	Current medicinal chemistry	2025	"Circ_0079471 Regulates the Proliferation, Migration, Invasion and Apoptosis of Osteosarcoma Cells by Mediating miR-485-3p and TRIP6."	hsa_circ_0079471	circ_0079471 			osteosarcomas 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ_0079471 is up-regulated in osteosarcoma tissues and cells. It promotes OS cell proliferation, cell-cycle progression, migration, invasion and xenograft tumor growth by sponging miR-485-3p and increasing TRIP6 expression. The study suggests circ_0079471 as a potential diagnostic and therapeutic target for OS."	0.7859
38181186	Cancer biotherapy & radiopharmaceuticals	2024	Curcumol Inhibits the Progression of Hepatocellular Carcinoma by Regulating the Expression of hsa_circ_0028861.	hsa_circ_0028861				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"This study found that hsa_circ_0028861 is up-regulated in HCC tumor tissues and HCC cell lines. Overexpression of hsa_circ_0028861 promotes proliferation, migration, EMT, and tumor growth, while curcumol suppresses these malignant phenotypes by downregulating hsa_circ_0028861. The circRNA is proposed as a potential therapeutic target for HCC."	0.5442
38182148	Annals of clinical and laboratory science	2023	Downregulated circ_0001681 Predicts the Occurrence and Malignant Development of Lung Carcinoma via Negatively Modulating miR-567.	hsa_circ_0001681	circ_0001681			lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; Microarray	"circ_0001681 is downregulated in LUAD serum, tumor tissues, and LUAD cell lines. Reduced circ_0001681 has diagnostic and prognostic value, while overexpression suppresses LUAD cell proliferation, migration, and invasion through negative modulation of miR-567."	0.7404
38184020	Gene	2024	Serum circPRDM5 as a novel diagnostic biomarker for acute myocardial infarction.	hsa_circ_0005654	circPRDM5	hsa_circ_PRDM5	PRDM5	acute myocardial infarction 	MONDO:0004781	acute myocardial infarction	down-regulated	RT-qPCR; Microarray	"Human serum circPRDM5 (hsa_circ_0005654) is significantly down-regulated in AMI patients compared with healthy controls and angina patients. It shows diagnostic utility for AMI, improves diagnostic sensitivity in combination with cTnT and CK-MB, increases after PCI, and may help monitor postoperative status and disease severity."	0.6548
38184020	Gene	2024	Serum circPRDM5 as a novel diagnostic biomarker for acute myocardial infarction.	mmu_circ_0001481	circPRDM5	mmu_circ_PRDM5	PRDM5	acute myocardial infarction 	MONDO:0004781	acute myocardial infarction	down-regulated	RT-qPCR	"Mouse circPRDM5 (mmu_circ_0001481) was validated by primer amplification and Sanger sequencing and measured in HL-1 mouse cardiomyocytes. Its expression was down-regulated under hypoxic conditions, supporting its potential relevance to an AMI cellular model, although no detailed mechanism was investigated."	0.385
38187044	American journal of cancer research	2023	EIF4A3 induced circGRIK2 promotes the malignancy of glioma by regulating the miR-1303/HOXA10 axis.	hsa_circ_0077500	circGRIK2 	hsa_circ_GRIK2	GRIK2	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR; RNA-seq	"circGRIK2 (hsa_circ_0077500) is a human circRNA derived from GRIK2 that is upregulated in glioma tissues and cell lines, with higher expression in higher WHO grades. It promotes glioma proliferation, viability, invasion, migration, and intracranial tumorigenesis by sponging miR-1303 and increasing HOXA10 expression. EIF4A3 binds and stabilizes circGRIK2, contributing to its elevated expression in glioma/glioblastoma."	0.8641
38190869	Experimental cell research	2024	circTldc1 increases Tldc1 expression by targeting miR-485-5p to promote fibroblast-like synoviocytes proliferation in collagen-induced arthritis.		circTldc1	rno_circ_Tldc1	Tldc1	rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; RNA-seq	"circTldc1 is up-regulated in FLSs from CIA rats and primarily localizes to the cytoplasm. It promotes Tldc1 expression by targeting miR-485-5p, thereby enhancing synovial fibroblast proliferation and inflammatory responses and worsening CIA joint damage. The study suggests that circTldc1 may be a potential RA biomarker and therapeutic target."	0.7344
38190869	Experimental cell research	2024	circTldc1 increases Tldc1 expression by targeting miR-485-5p to promote fibroblast-like synoviocytes proliferation in collagen-induced arthritis.		circHerpud2	rno_circ_Herpud2	Herpud2	rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	down-regulated	RT-qPCR; RNA-seq	"circHerpud2 was identified as a down-regulated circRNA in both synovial tissues and FLSs from CIA rats during circRNA expression profiling and validation. The paper did not further characterize its mechanism or biological function, focusing subsequent mechanistic experiments on circTldc1."	0.385
38205898	Environmental toxicology	2024	Molecular mechanism of circHIPK3 in mitochondrial function in septic acute kidney injury.		circular RNA HIPK3 	hsa_circ_HIPK3	HIPK3	septic acute kidney injury 	MONDO:0005229	bacterial infectious disease with sepsis	unknown	RT-qPCR	"This study identifies circHIPK3 as a pathogenic regulator in septic acute kidney injury models. circHIPK3 promotes glycolysis, lactate production, mitochondrial dysfunction, and cell senescence through the miR-148b-3p/DNMT1/3a/Klotho axis and by counteracting MPC1-mediated inhibition of lactate production; silencing circHIPK3 improves mitochondrial function and kidney injury phenotypes."	0.4245
38205898	Environmental toxicology	2024	Molecular mechanism of circHIPK3 in mitochondrial function in septic acute kidney injury.		circular RNA HIPK3 	mmu_circ_HIPK3	HIPK3	septic acute kidney injury 	MONDO:0005229	bacterial infectious disease with sepsis	unknown	RT-qPCR	"This study identifies circHIPK3 as a pathogenic regulator in septic acute kidney injury models. circHIPK3 promotes glycolysis, lactate production, mitochondrial dysfunction, and cell senescence through the miR-148b-3p/DNMT1/3a/Klotho axis and by counteracting MPC1-mediated inhibition of lactate production; silencing circHIPK3 improves mitochondrial function and kidney injury phenotypes."	0.4245
38206529	Molecular biotechnology	2024	Hsa_circular RNA_0045474 Facilitates Osteoarthritis Via Modulating microRNA-485-3p and Augmenting Transcription Factor 4.	hsa_circ_0045474		hsa_circ_KPNA2	KPNA2	osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"hsa_circ_0045474 is up-regulated in OA patient serum and IL-1beta-stimulated chondrocytes. It promotes OA-related chondrocyte injury by sponging miR-485-3p and regulating TCF4, leading to extracellular matrix degradation, inflammatory cytokine secretion, and apoptosis. Knockdown of circ_0045474 alleviates OA-like cellular phenotypes and OA progression in an ACLT mouse model."	0.7519
38211649	Cancer letters	2024	N6-methyladenosine-modified CircPSMA7 enhances bladder cancer malignancy through the miR-128-3p/MAPK1 axis.	hsa_circ_0003456	circPSMA7 	hsa_circ_PSMA7	PSMA7	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; RNA-seq	"circPSMA7/hsa_circ_0003456 is up-regulated in bladder cancer tissues and cell lines and is associated with higher tumor grade and stage. Mechanistically, m6A-modified circPSMA7 is stabilized by IGF2BP3 and promotes proliferation, migration, metastasis, cell-cycle progression and EMT by sponging miR-128-3p to increase MAPK1 expression. The study proposes circPSMA7 as a potential diagnostic, prognostic and therapeutic biomarker for BCa."	0.8877
38214360	Recent patents on anti-cancer drug discovery	2024	Circ_0070203 Promotes Epithelial-mesenchymal Transition in Ovarian Serous Cystadenocarcinoma through miR-370-3p/TGFbetaR2 Axis.	hsa_circ_0070203	circ_0070203	hsa_circ_BMP2K	BMP2K	Ovarian serous cystadenocarcinoma 	MONDO:0006046	ovarian serous cystadenocarcinoma	up-regulated	RT-qPCR; Microarray	"circ_0070203 is up-regulated in ovarian serous cystadenocarcinoma tissues and SKOV-3 cells. It promotes EMT, migration, invasion and metastasis by sponging miR-370-3p to regulate TGFbetaR2 and TGF-beta/SMAD-related signaling. The study suggests circ_0070203 may serve as a predictive marker and potential molecular target in ovarian cancer."	0.6777
38217675	Digestive diseases and sciences	2024	Hsa_circ_0014606 Derived from Exosomes Promotes Gastric Carcinoma Tumorigenesis and Proliferation by Sponging miR-514b-3p to Upregulate HNRNPC.	hsa_circ_0014606				gastric carcinoma 	MONDO:0004950	gastric carcinoma	up-regulated	RT-qPCR	"Exosome-derived hsa_circ_0014606 is up-regulated in gastric cancer serum exosomes and functions as an oncogenic circRNA. Knockdown suppresses proliferation, migration, invasion and tumor growth while increasing apoptosis, and the mechanism involves sponging miR-514b-3p to upregulate HNRNPC."	0.6542
38224284	Acta neurobiologiae experimentalis	2023	The protective role of circ_0016760 downregulation against sevoflurane_induced neurological impairment via modulating miR_145 expression in aged rats.	hsa_circ_0016760	circ_0016760			sevoflurane-induced neurological impairment 	MONDO:0005527	toxic encephalopathy	up-regulated	RT-qPCR; Microarray	"circ_0016760 is up-regulated in POCD patient data and in sevoflurane-treated HT22 cells and aged rat hippocampal tissues. The study shows that circ_0016760 knockdown protects against sevoflurane-induced neurological impairment by targeting miR-145, reducing apoptosis, neuroinflammation, oxidative stress, and cognitive dysfunction."	0.5979
38224924	Gene	2024	5-methylcytosine-mediated upregulation of circular RNA 0102913 augments malignant properties of colorectal cancer cells through a microRNA-571/Rac family small GTPase 2 axis.	hsa_circ_0102913	circRNA_0102913 	hsa_circ_ATXN3	ATXN3	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circ_0102913 is a human ATXN3-derived circRNA that is up-regulated in colorectal cancer tissues and cell lines. It promotes CRC cell proliferation, migration, invasion, and xenograft tumor growth by sponging miR-571 and restoring RAC2 expression. Its elevated expression is attributed at least partly to NSUN5-associated m5C modification, which increases circ_0102913 stability."	0.8275
38226841	Molecular carcinogenesis	2024	circRNA TATA-box binding protein associated factor 15 acts as an oncogene to facilitate bladder cancer progression through targeting miR-502-5p/high mobility group box 3.	hsa_circ_0000758	circRNA TATA-box binding protein associated factor 15 	hsa_circ_TAF15	TAF15	bladder cancer	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circTAF15 is an oncogenic circRNA upregulated in bladder cancer and associated with poor patient outcomes. Functionally, circTAF15 promotes bladder cancer cell viability, proliferation, migration, invasion, EMT, glycolysis, and xenograft tumor growth. Mechanistically, it acts through a circTAF15/miR-502-5p/HMGB3 axis by suppressing miR-502-5p and thereby increasing HMGB3 expression."	0.8868
38228844	Biochemical genetics	2024	Circ_FNDC3B Promotes Cell Proliferation and Metastasis in Esophageal Squamous Cell Carcinoma via Regulating MAPK1 by Binding to miR-136-5p.	hsa_circ_0006948	Circ_FNDC3B 	hsa_circ_FNDC3B	FNDC3B	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"circ_FNDC3B is up-regulated in ESCC tissues and cells and acts as an oncogenic circRNA. Its knockdown suppresses proliferation, migration, invasion, EMT and xenograft tumor growth while promoting apoptosis. Mechanistically, circ_FNDC3B sponges miR-136-5p to increase MAPK1 expression, forming a circ_FNDC3B/miR-136-5p/MAPK1 axis associated with malignant ESCC progression."	0.7859
38230773	Chemical biology & drug design	2024	Astragaloside IV regulates circ_0001615 and miR-873-5p/LASP1 axis to suppress colorectal cancer cell progression.	hsa_circ_0001615	circ_0001615 	hsa_circ_PHIP		colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0001615 is up-regulated in CRC tissues and cell lines and functions as an oncogenic circRNA that promotes proliferation, migration, and tumor growth while inhibiting apoptosis. AS-IV suppresses CRC progression partly by downregulating circ_0001615, which relieves circ_0001615-mediated sponging of miR-873-5p and reduces LASP1 expression."	0.7552
38234074	Experimental lung research	2024	Hsa_circ_0008833 promotes COPD progression via inducing pyroptosis in bronchial epithelial cells.	hsa_circ_0008833		hsa_circ_SAMD3	SAMD3	chronic obstructive pulmonary disease 	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR; RNA-seq; Microarray	"Hsa_circ_0008833 is up-regulated in COPD-related samples and in LPS-treated bronchial epithelial cells. The study suggests that it promotes COPD progression by encoding a 57-amino acid peptide that induces bronchial epithelial cell pyroptosis, with increased Caspase-1, IL-18, IL-1beta, NLRP3, ASC and cleaved GSDMD. It may serve as a potential diagnostic and therapeutic target for COPD."	0.6815
38235556	"Arteriosclerosis, thrombosis, and vascular biology"	2024	Exosomes From IgE-Stimulated Mast Cells Aggravate Asthma-Mediated Atherosclerosis Through circRNA CDR1as-Mediated Endothelial Cell Dysfunction in Mice.		circular RNA CDR1as 			asthma-mediated atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR; ISH	"CDR1as is upregulated in IgE-stimulated mast-cell-derived exosomes and in plasma from patients with atherosclerosis, especially those with allergy history. Exosomal CDR1as is transferred to endothelial cells and promotes endothelial adhesion dysfunction and inflammatory responses through the FUS-phos-p65 axis, thereby aggravating asthma-induced atherosclerosis. In vivo CDR1as knockdown reduces endothelial adhesion markers, inflammatory infiltration, and atherosclerotic lesions, supporting CDR1as as a potential biomarker and therapeutic target."	0.7076
38235556	"Arteriosclerosis, thrombosis, and vascular biology"	2024	Exosomes From IgE-Stimulated Mast Cells Aggravate Asthma-Mediated Atherosclerosis Through circRNA CDR1as-Mediated Endothelial Cell Dysfunction in Mice.		circular RNA CDR1as 			asthma-mediated atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR; ISH	"CDR1as is upregulated in IgE-stimulated mast-cell-derived exosomes and in plasma from patients with atherosclerosis, especially those with allergy history. Exosomal CDR1as is transferred to endothelial cells and promotes endothelial adhesion dysfunction and inflammatory responses through the FUS-phos-p65 axis, thereby aggravating asthma-induced atherosclerosis. In vivo CDR1as knockdown reduces endothelial adhesion markers, inflammatory infiltration, and atherosclerotic lesions, supporting CDR1as as a potential biomarker and therapeutic target."	0.7076
38243004	Biochemical genetics	2024	"Circ_0023990 Promotes the Proliferation, Invasion, and Glycolysis of Esophageal Squamous Cell Carcinoma Cells Via Targeting miR-6884-5p/PAK1 Axis."	hsa_circ_0023990	circ_0023990			esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0023990 is up-regulated in ESCC tissues and cell lines, and high expression is associated with poorer overall survival. Functionally, circ_0023990 promotes ESCC cell proliferation, invasion, glycolysis, and xenograft tumor growth. Mechanistically, it acts mainly through the miR-6884-5p/PAK1 axis."	0.8066
38244155	Journal of bioenergetics and biomembranes	2024	Human milk exosome-derived circDNAJB6 improves bronchopulmonary dysplasia model by promoting DNAJB6 gene transcription.	hsa_circ_0083171	circDNAJB6 	hsa_circ_DNAJB6	DNAJB6	Bronchopulmonary dysplasia 	MONDO:0019091	bronchopulmonary dysplasia	unknown	RT-qPCR	"This study identifies human milk exosome-derived circDNAJB6 as a protective circRNA in hyperoxia-induced experimental BPD models. circDNAJB6 is mainly nuclear in AT II cells and promotes transcription of its host gene DNAJB6, thereby improving AT II cell viability and proliferation and reducing alveolar epithelial injury in vitro and in vivo."	0.7927
38244519	International immunopharmacology	2024	Downregulation of circular RNA ETS1 promotes SLE activity and inhibits Treg cell differentiation through miR-1205/FoxP3 molecular axis.		circETS1 	hsa_circ_ETS1	ETS1	systemic lupus erythematosus 	MONDO:0007915	systemic lupus erythematosus	down-regulated	RT-qPCR	"circETS1 is down-regulated in CD4 + T cells from SLE patients. The study proposes that circETS1 participates in a ceRNA regulatory axis with miR-1205 and FoxP3/FoxP3 mRNA, influencing CD4 + T cell differentiation and Th17/Treg imbalance in SLE. circETS1-related regulation may have therapeutic relevance for SLE activity."	0.6287
38247231	Journal of biomolecular structure & dynamics	2025	Tanreqing suppresses the proliferation and migration of non-small cell lung cancer cells by mediating the inactivation of the HIF1alpha signaling pathway via exosomal circ-WDR78.		ASCRP000647 	hsa_circ_WDR78	WDR78	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"circ-WDR78 is a TRQ-induced, exosome-transmitted circRNA with tumor-suppressive activity in NSCLC cells. It sponges miR-1265 to derepress FBXW8, promoting HIF1a degradation, ROS accumulation, autophagy, and reduced PD-L1-mediated immune escape, thereby inhibiting proliferation, invasion, and migration while promoting apoptosis."	0.7998
38253900	Molecular biotechnology	2024	Circ_0007422 Knockdown Inhibits Tumor Property and Immune Escape of Colorectal Cancer by Decreasing PDL1 Expression in a miR-1256-Dependent Manner.	hsa_circ_0007422	hsa_circRNA_102885 			colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"Circ_0007422 is upregulated in colorectal cancer tissues and cell lines, and high expression is associated with poorer prognosis. Functionally, circ_0007422 promotes CRC proliferation, invasion, stemness, tumor growth and immune escape while suppressing apoptosis and antitumor immune activity. Mechanistically, it acts through a circ_0007422/miR-1256/PDL1 regulatory axis."	0.8596
38261157	Biochemical genetics	2024	FUS-Mediated CircFGFR1 Accelerates the Development of Papillary Thyroid Carcinoma by Stabilizing FGFR1 Protein.	hsa_circ_0008016	circFGFR1 	hsa_circ_FGFR1	FGFR1	Papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"hsa_circ_0008016/circFGFR1 is up-regulated in PTC cells and functions as an oncogenic circRNA by promoting proliferation and inhibiting apoptosis. FUS promotes circFGFR1 formation, and circFGFR1 stabilizes FGFR1 protein by interacting with CBL and suppressing CBL-mediated FGFR1 ubiquitination and degradation. The study proposes circFGFR1 as a potential therapeutic target in PTC."	0.6578
38262261	Journal of reproductive immunology	2024	"Circ_0030042 inhibits trophoblast cell growth, invasion and epithelial-mesenchymal transition process in preeclampsia via miR-942-5p/LITAF."	hsa_circ_0030042	circ_0030042			preeclampsia 	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR	"circ_0030042 is up-regulated in placental tissues from preeclampsia patients. In trophoblast cells, circ_0030042 inhibits growth, invasion, migration and EMT while promoting apoptosis, acting through a ceRNA mechanism that sponges miR-942-5p and increases LITAF expression. The study proposes the circ_0030042/miR-942-5p/LITAF axis as a potential therapeutic target for PE."	0.7799
38266697	"Environmental pollution (Barking, Essex : 1987)"	2024	Circular RNA circRest regulates manganese induced cell apoptosis by targeting the mmu-miR-6914-5p/Ephb3 axis.		circRest	mmu_circ_Rest	Rest	manganese induced neurotoxicity 	MONDO:0017638	manganese poisoning	down-regulated	RT-qPCR; RNA-seq	"In this study, circRest is a mouse circRNA derived from exon 3 of Rest and is significantly downregulated in Mn-treated N2a cells. Functionally, circRest overexpression increases cell viability and suppresses Mn-induced apoptosis, while circRest knockdown has the opposite effect. Mechanistically, cytoplasmic circRest acts as a sponge for mmu-miR-6914-5p to regulate Ephb3 mRNA/protein expression, forming a circRest/mmu-miR-6914-5p/Ephb3 axis that may attenuate Mn-induced neurotoxicity and influence learning and memory impairment in Mn-treated mice."	0.8024
38266777	Behavioural brain research	2024	CircPTK2 may be associated with depressive-like behaviors by influencing miR-182-5p.		circRNA protein tyrosine kinase 2 (circPTK2) 	hsa_circ_PTK2	PTK2	Major depressive disorder 	MONDO:0002009	major depressive disorder	down-regulated	RT-qPCR	"circPTK2 is down-regulated in PBMCs from MDD patients and in the hippocampus of CUMS mice. Its overexpression in the hippocampus alleviates depressive-like behavioral deficits, likely by sponging miR-182-5p, and it may have diagnostic and therapeutic relevance in MDD."	0.7905
38266777	Behavioural brain research	2024	CircPTK2 may be associated with depressive-like behaviors by influencing miR-182-5p.		circRNA protein tyrosine kinase 2 (circPTK2) 	mmu_circ_PTK2	PTK2	Major depressive disorder 	MONDO:0002009	major depressive disorder	down-regulated	RT-qPCR	"circPTK2 is down-regulated in PBMCs from MDD patients and in the hippocampus of CUMS mice. Its overexpression in the hippocampus alleviates depressive-like behavioral deficits, likely by sponging miR-182-5p, and it may have diagnostic and therapeutic relevance in MDD."	0.7905
38266777	Behavioural brain research	2024	CircPTK2 may be associated with depressive-like behaviors by influencing miR-182-5p.		circKIAA0907	hsa_circ_KIAA0907	KIAA0907	Major depressive disorder 	MONDO:0002009	major depressive disorder	down-regulated	RT-qPCR	"circKIAA0907 was included in an initial clinical qRT-PCR screen of candidate circRNAs predicted to bind miR-182-5p. It was down-regulated in PBMCs from MDD patients and showed moderate diagnostic discrimination, but the study did not pursue mechanistic or functional validation for this circRNA."	0.459
38269483	Autoimmunity	2024	"CircNRIP1 promotes proliferation, migration and phenotypic switch of Ang II-induced HA-VSMCs by increasing CXCL5 mRNA stability via recruiting IGF2BP1."		circNRIP1	hsa_circ_NRIP1	NRIP1	thoracic aortic dissection 	MONDO:0005561	aortic disorder	up-regulated	RT-qPCR; Microarray	"circNRIP1 is up-regulated in TAD patient aortic specimens and Ang II-induced HA-VSMCs. It promotes HA-VSMC proliferation, migration and phenotypic switch by binding/recruiting the RBP IGF2BP1 to enhance CXCL5 mRNA stability, suggesting the circNRIP1/IGF2BP1/CXCL5 axis as a potential therapeutic target for TAD."	0.7968
38270096	Expert opinion on therapeutic targets	2024	Tumor cells-derived extracellular vesicles carry circ_0064516 competitively inhibit microRNA-6805-3p and promote cervical cancer angiogenesis and tumor growth.	hsa_circ_0064516	circ_0064516 	hsa_circ_ANKRD28	ANKRD28	cervical cancer	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"This study identifies circ_0064516/hsa_circ_0064516, derived from ANKRD28, as an up-regulated exosomal circRNA in cervical cancer. Tumor cell-derived exosomes transfer circ_0064516 into HUVECs, where it sponges miR-6805-3p to elevate MAPK1, thereby promoting endothelial migration, angiogenesis, tumor growth, and metastasis in cervical cancer models."	0.8278
38272402	International journal of biological macromolecules	2024	Hsa_circ_0086414/transducer of ERBB2 (TOB2) axis-driven lipid elimination and tumor suppression in clear cell renal cell cancer via perilipin 3.	hsa_circ_0086414	circRNA_0086414 	hsa_circ_BNC2	BNC2	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0086414 is downregulated in ccRCC tissues and cells and functions as a tumor suppressor. It sponges miR-661 to increase TOB2 expression, leading to PLIN3 inhibition and reduced ccRCC proliferation, metastasis, EMT-related changes, and lipid accumulation."	0.8455
38273153	Biochemical genetics	2024	circRNA-CPA4 Regulates Cell Proliferation and Apoptosis of Non-small Cell Lung Cancer via the miR-1183/PDPK1 Axis.		circRNA-CPA4 	hsa_circ_CPA4	CPA4	Non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	circRNA-CPA4 is up-regulated in NSCLC cell lines and functions as an oncogenic circRNA. It promotes proliferation and tumor growth while suppressing apoptosis by sponging miR-1183 and increasing PDPK1 expression. Knockdown of circRNA-CPA4 inhibits NSCLC cell proliferation and xenograft growth and promotes apoptosis.	0.7295
38273751	Discovery medicine	2024	CircRNA Hsa_circ_0120175 Promotes Ovarian Cancer Tumorigenesis and Predicts a Poor Prognosis.	hsa_circ_0120175		hsa_circ_EPCAM	EPCAM	ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0120175 is an EPCAM-derived human circRNA that is up-regulated in ovarian cancer tissues and cell lines. The study supports an oncogenic role, as knockdown of hsa_circ_0120175 reduced OC cell proliferation, migration, and invasion in vitro. Clinically, higher hsa_circ_0120175 expression was associated with FIGO stage and poorer overall survival, suggesting potential biomarker value."	0.8057
38281266	Molecular biotechnology	2025	Investigation of Circular RNA Expression Profiles in Ultrasound-guided Incomplete Radiofrequency Ablation Transplanted Tumor Models of Human Liver Cancer.		hsa_circRNA_103595	hsa_circ_MAN2B2	MAN2B2	liver cancer 	MONDO:0002691	liver cancer	up-regulated	RT-qPCR; Microarray	hsa_circRNA_103595 was up-regulated in incomplete RFA-treated HepG2 xenograft liver cancer tumors and validated by qPCR. The study further confirmed that hsa-miR-185-3p binds hsa_circRNA_103595 by dual-luciferase assay and proposed a ceRNA regulatory network involving predicted target mRNAs.	0.5495
38281266	Molecular biotechnology	2025	Investigation of Circular RNA Expression Profiles in Ultrasound-guided Incomplete Radiofrequency Ablation Transplanted Tumor Models of Human Liver Cancer.		hsa_circRNA_001264			liver cancer 	MONDO:0002691	liver cancer	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_001264 was down-regulated in incomplete RFA-treated HepG2 xenograft liver cancer tumors and its expression change was validated by qPCR. The study annotated predicted circRNA/miRNA interactions for hsa_circRNA_001264, but did not report a specific validated miRNA target or functional phenotype for this circRNA."	0.4474
38284251	Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology	2024	"[Circular RNA Cbl proto-oncogene B (circCBLB) inhibits proliferation, promotes apoptosis, and increases anti-inflammatory cytokine levels of fibroblast-like synoviocytes in rheumatoid arthritis]."		circular RNA Cbl proto-oncogene B 	hsa_circ_CBLB		rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	unknown	RT-qPCR	"This study identifies circCBLB as a functional regulator in TNF-alpha-induced rheumatoid arthritis fibroblast-like synoviocytes. circCBLB suppresses RA-FLS proliferative activity and colony formation, promotes apoptosis and cell-cycle prolongation, shifts cytokine production toward an anti-inflammatory profile, and acts through a circCBLB/miR-486-5p regulatory relationship."	0.5627
38286403	Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme	2024	Hsa_circ_0092355 Accelerates Papillary Thyroid Cancer Progression by Regulating the miR-543/PDE5A Pathway.	hsa_circ_0092355	circ_0092355 	hsa_circ_EXOC7	EXOC7	papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"hsa_circ_0092355 is up-regulated in papillary thyroid cancer tissues and cells and acts as a tumor promoter. Mechanistically, it sponges miR-543 to regulate PDE5A, thereby promoting proliferation, colony formation, migration, and xenograft tumor growth while suppressing apoptosis. The study suggests hsa_circ_0092355 as a potential biomarker and therapeutic target for PTC."	0.7795
38290402	"Pathology, research and practice"	2024	"Identification of miRNA, lncRNA and circRNA associated with gastric cancer metabolism through sequencing and bioinformatics analysis."		CCSER2	hsa_circ_CCSER2		gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"CCSER2 was identified as an up-regulated key circRNA in gastric cancer tissues and validated by qRT-PCR. The study suggests that key circRNAs may be related to gastric cancer metabolic regulation, especially tumor metabolism-related proteins, enzymes, and energies, although direct functional validation was not performed."	0.4032
38290402	"Pathology, research and practice"	2024	"Identification of miRNA, lncRNA and circRNA associated with gastric cancer metabolism through sequencing and bioinformatics analysis."		FNDC3B 	hsa_circ_FNDC3B	FNDC3B	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; RNA-seq	"FNDC3B/circFNDC3B was identified as a down-regulated key circRNA in gastric cancer tissues and validated by qRT-PCR. It is generated from the FNDC3B gene, and the study suggests key circRNAs may be linked to metabolic regulation and carcinometabolic enzyme activity in gastric cancer."	0.4032
38290402	"Pathology, research and practice"	2024	"Identification of miRNA, lncRNA and circRNA associated with gastric cancer metabolism through sequencing and bioinformatics analysis."		CORO1C 	hsa_circ_CORO1C	CORO1C	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; RNA-seq	"CORO1C/CircCORO1C was identified as a down-regulated key circRNA in gastric cancer tissues and validated by qRT-PCR. The paper describes it as derived from coronin-like actin-binding protein 1 C, and the study suggests key circRNAs may be associated with metabolic regulation and carcinometabolic enzyme activity in gastric cancer."	0.4032
38290402	"Pathology, research and practice"	2024	"Identification of miRNA, lncRNA and circRNA associated with gastric cancer metabolism through sequencing and bioinformatics analysis."		FAM214A	hsa_circ_FAM214A		gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; RNA-seq	"FAM214A was identified as a down-regulated key circRNA in gastric cancer tissues and validated by qRT-PCR. The study suggests that key circRNAs may be related to gastric cancer metabolic regulation, especially tumor metabolism-related proteins, enzymes, and energies, but functional experiments were not performed."	0.4032
38299319	Environmental toxicology	2024	N6-Methyladenosine reader HNRNPC-mediated downregulation of circITCH prevents miR-224-3p sequestering and contributes to tumorigenesis in nasopharyngeal carcinoma.	hsa_circ_0059948	CircITCH 	hsa_circ_ITCH	ITCH	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	down-regulated	RT-qPCR	"circITCH is down-regulated in NPC cell lines and functions as a tumor-suppressive circRNA. Its overexpression suppresses proliferation, migration and invasion while promoting apoptosis, mainly by sponging miR-224-3p; HNRNPC directly interacts with circITCH and is proposed to reduce circITCH expression in an m6A-related regulatory context."	0.627
38304630	Cytotechnology	2024	Exosome-mediated circGMPS facilitates the development of gastric cancer cells through miR-144-3p/PUM1.	hsa_circ_0001351	circGMPS	hsa_circ_GMPS	GMPS	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circGMPS is up-regulated in gastric cancer serum-derived exosomes, tumor tissues, GC cells and GC cell-derived exosomes, and high expression is associated with poor prognosis. Exosome-transported circGMPS promotes GC cell proliferation, migration and invasion by sponging miR-144-3p and increasing PUM1 expression, suggesting a potential biomarker and therapeutic target role."	0.7078
38310363	Toxicological sciences : an official journal of the Society of Toxicology	2024	Circ0087385 promotes DNA damage in benzo(a)pyrene-induced lung cancer development by upregulating CYP1A1.		circ0087385	hsa_circ_AGTPBP1	AGTPBP1	lung cancer 	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; Microarray	"circ0087385 is a human AGTPBP1-derived circRNA that is upregulated after BaP exposure and in lung cancer cells, tissues, and serum exosomes. It promotes BaP-induced DNA damage and malignant transformation by upregulating CYP1A1, increasing BPDE-DNA adduct formation, enhancing proliferation and cell cycle progression, and suppressing apoptosis."	0.7471
38312030	General physiology and biophysics	2024	CircRSU1 alleviates LPS-induced human pulmonary microvascular endothelial cell injury by targeting miR-1224-5p/ITGA5 axis.	hsa_circ_0006577	CircRSU1	hsa_circ_RSU1	RSU1	septic acute lung injury 	MONDO:0005229	bacterial infectious disease with sepsis	down-regulated	RT-qPCR	"This study found that circRSU1 is down-regulated in LPS-induced HPMECs, an in vitro model of sepsis-ALI. Restoring circRSU1 alleviated endothelial injury by suppressing inflammatory cytokine changes, promoting migration and tube formation, reducing permeability, and maintaining tight junction proteins. Mechanistically, circRSU1 acts through the miR-1224-5p/ITGA5 axis."	0.7216
38316263	Gene	2024	"The biogenesis, identification, and functionality of circWWP2 in lipopolysaccharide stimulated macrophages."		circular RNA WWP2 	gga_circ_WWP2		bacterial infection 	MONDO:0005113	bacterial infectious disease	down-regulated	RNA-seq	"Chicken circWWP2 is a stable circular RNA derived from WWP2 exons 2 to 4 and is downregulated in chicken macrophages during bacterial infection. In LPS-stimulated macrophages, circWWP2 overexpression exacerbates cellular injury by reducing viability and increasing inflammatory cytokines, pro-apoptotic genes, and NO production, while bioinformatics predicts a circWWP2-miRNA-mRNA network enriched in immune and Notch-related pathways."	0.6631
38317294	Environmental toxicology	2024	Hsa_circ_0008133 contributes to lung cancer progression by promoting glycolysis metabolism through the miR-760/MEX3A axis.	hsa_circ_0008133	circ_0008133	hsa_circ_CLTA		lung cancer 	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"Hsa_circ_0008133 is up-regulated in lung cancer tissues and cell lines. It functions as a tumor-promoting circRNA that enhances cell viability, proliferation, migration, invasion, glycolysis metabolism, and xenograft tumor growth. Mechanistically, it sponges miR-760 to up-regulate MEX3A expression."	0.7552
38317501	Environmental toxicology	2024	Circ_0000877 accelerates proliferation and immune escape of non-small cell lung cancer cells by regulating microRNA-637/E2F2 axis.	hsa_circ_0000877	CircRNA_0000877 			non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"In this study, circ_0000877 was up-regulated in NSCLC tissues and cell lines, and high expression was associated with clinicopathological progression and poor overall survival. Functionally, circ_0000877 promoted NSCLC cell proliferation, immune escape, and tumor growth while suppressing apoptosis. Mechanistically, circ_0000877 directly interacted with miR-637 and regulated the downstream target E2F2, forming a circ_0000877/miR-637/E2F2 axis."	0.8067
38321980	Autoimmunity	2024	Circ_0036490 and DKK1 competitively bind miR-29a to promote lipopolysaccharides-induced human gingival fibroblasts injury.	hsa_circ_0036490	circ_0036490	hsa_circ_MORF4L1	MORF4L1	periodontitis	MONDO:0005076	periodontitis	up-regulated	RT-qPCR	"circ_0036490 is up-regulated in LPS-treated human gingival fibroblasts and promotes periodontitis-like cellular injury. Mechanistically, it binds miR-29a and acts with DKK1 in a competitive endogenous RNA axis, reducing miR-29a protective activity and promoting pyroptosis, apoptosis, inflammatory mediator release, and Wnt/beta-catenin pathway suppression in vitro."	0.7721
38323291	American journal of cancer research	2024	Upregulation of circRNA_0023685 promotes gastric cancer progression via a circRNA-miRNA-mRNA interaction network.	hsa_circ_0023685	circRNA_0023685 	hsa_circ_PAK1	PAK1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circRNA_0023685 is upregulated in gastric cancer plasma, tissues and cell lines. Functional knockdown experiments indicate that it promotes GC proliferation, migration and xenograft tumor growth while suppressing apoptosis. Mechanistically, the study proposes a circRNA-miRNA-mRNA ceRNA network in which circRNA_0023685 regulates APP, supporting its potential as a diagnostic biomarker and therapeutic target."	0.6772
38330446	The Journal of pharmacy and pharmacology	2024	Ganoderic acid A suppresses autophagy by regulating the circFLNA/miR-486-3p/CYP1A1/XRCC1 axis to strengthen the sensitivity of lung cancer cells to cisplatin.		circFLNA 	hsa_circ_FLNA		lung cancer 	MONDO:0008903	lung cancer	unknown	RT-qPCR	"This study identifies circFLNA as a component of the GA-A-responsive circFLNA/miR-486-3p/CYP1A1/XRCC1 axis in lung cancer. GA-A downregulates circFLNA, suppresses autophagy, promotes apoptosis, and strengthens cisplatin sensitivity, whereas circFLNA overexpression reverses these anti-tumor and chemosensitizing effects."	0.4236
38340287	Journal of applied genetics	2024	Peptidylprolyl isomerase D circular RNA sensitizes breast cancer to trastuzumab through remodeling HER2 N4-acetylcytidine modification.		circ-PPID 	hsa_circ_PPID	PPID	HER2-positive breast cancer 	MONDO:0006244	HER2 positive breast carcinoma	down-regulated	RT-qPCR; RNA-seq	"Circ-PPID is a PPID-derived circular RNA that is downregulated in trastuzumab-resistant HER2-positive breast cancer cells and tissues, and high expression is linked to longer survival. Functionally, circ-PPID restores trastuzumab sensitivity by binding nuclear NAT10, reducing NAT10-mediated HER2 mRNA ac4C modification and HER2 mRNA stability, thereby decreasing HER2 signaling. XPO4-mediated nuclear export shifts circ-PPID toward the cytoplasm in resistant cells, weakening its nuclear NAT10 interaction and contributing to resistance."	0.8747
38341124	Cellular signalling	2024	Circ-FOXO3 inhibits triple-negative breast cancer growth and metastasis via regulating WHSC1-H3K36me2-Zeb2 axis.		circ-FOXO3	hsa_circ_FOXO3	FOXO3a	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	down-regulated	RT-qPCR; ISH; RNA-seq	"Circ-FOXO3 is a human FOXO3a-derived circRNA that is downregulated in TNBC tissues, cells, and blood/plasma. It suppresses TNBC proliferation, invasion, EMT, and metastasis by binding WHSC1 and inhibiting the WHSC1-H3K36me2-Zeb2 axis. Clinically, low circ-FOXO3 expression is associated with lymph node metastasis and unfavorable outcome, while higher expression predicts better prognosis."	0.8973
38341369	Clinical breast cancer	2024	Interference of the Circular RNA Sperm Antigen With Calponin Homology and Coiled-Coil Domains 1 Suppresses Growth and Promotes Apoptosis of Breast Cancer Cells Partially Through Targeting miR-1236-3p/Chromobox 8 Pathway.	hsa_circ_0000745	circSPECC1	hsa_circ_SPECC1	SPECC1	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"This study shows that human circSPECC1 (hsa_circ_0000745), derived from SPECC1, is up-regulated in breast cancer tumors and cells and is further induced by radiation. Functionally, circSPECC1 supports BC cell growth and survival while suppressing apoptosis, and its knockdown inhibits xenograft tumor growth. Mechanistically, circSPECC1 acts through a miR-1236-3p/CBX8 regulatory axis and may represent a therapeutic target in BC."	0.8298
38343018	Cell biochemistry and function	2024	Downregulated circRNA_CDKN1A promotes gallbladder cancer progression through activation of the NF-kappaB pathway.	hsa_circ_0076194	CircRNA_CDKN1A 	hsa_circ_CDKN1A	CDKN1A	gallbladder cancer 	MONDO:0005411	gallbladder cancer	up-regulated	RT-qPCR; RNA-seq	"This study identifies circRNA_CDKN1A as a tumor-suppressive circRNA in gallbladder cancer. Loss or knockdown of circRNA_CDKN1A promotes GBC cell proliferation, migration, invasion, EMT and stem-like traits while reducing apoptosis, largely through activation of the NF-kappaB signaling pathway."	0.5101
38345168	Journal of biochemical and molecular toxicology	2024	SCARB1-encoded circ _0029343 induces p73 splicing to promote growth and metastasis of hepatocellular carcinoma via miR-486-5p/SRSF3 axis.	hsa_circ_0029343	circ _0029343 	hsa_circ_SCARB1	SCARB1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"SCARB1-encoded circ_0029343 is up-regulated in HCC tissues and cell lines. It promotes HCC cell proliferation, migration, invasion, growth and metastasis while suppressing apoptosis, mainly by sponging miR-486-5p, increasing SRSF3, inducing p73 splicing, and activating PDGF-PDGFRB-related signaling."	0.6545
38348636	Journal of neurochemistry	2024	Reduced circ_lrrc49 in trigeminal ganglion contributes to neuropathic pain in mice by downregulating Ist1 and impairing autophagy.		circ_lrrc49 	mmu_circ_Lrrc49	Lrrc49	orofacial neuropathic pain	MONDO:0021667	neuralgia	down-regulated	RT-qPCR; RNA-seq	"This study identifies mouse circ_lrrc49 as a downregulated circRNA in trigeminal ganglion neurons after CCI-ION-induced orofacial neuropathic pain. circ_lrrc49 directly interacts with Ist1, and reduced circ_lrrc49 decreases Ist1, impairs autophagy, and promotes mechanical hypersensitivity; overexpression of circ_lrrc49 or Ist1 and autophagy activation alleviate pain behavior."	0.7708
38348717	Journal of biochemical and molecular toxicology	2024	Exosomal circ_0037104 derived from Hu-MSCs inhibits cholangiocarcinoma progression by sponging miR-620 and targeting AFAP1.	hsa_circ_0037104	circ_0037104 	hsa_circ_PCSK6	PCSK6	cholangiocarcinoma 	MONDO:0019087	cholangiocarcinoma	down-regulated	RT-qPCR; RNA-seq	"circ_0037104 is downregulated in cholangiocarcinoma and is enriched in Hu-MSC-derived exosomes. It suppresses CCA proliferation, migration, invasion, metastasis, EMT, and stemness by sponging miR-620 and regulating the AFAP1/APAF1 axis. The study suggests that Hu-MSC exosomal circ_0037104 may have diagnostic biomarker and therapeutic relevance in CCA."	0.8634
38365078	"Environmental pollution (Barking, Essex : 1987)"	2024	Role of circPSEN1 in carbon black and cadmium co-exposure induced autophagy-dependent ferroptosis in respiratory epithelial cells.	hsa_circ_0008218	circPSEN1 	hsa_circ_PSEN1	PSEN1	CBNPs-Cd-induced respiratory system damage 	MONDO:0008903	lung cancer	down-regulated	Microarray	"In CBNPs-Cd-exposed human bronchial epithelial cells, circPSEN1 is downregulated and acts as a regulator of autophagy-dependent ferroptosis. Mechanistically, circPSEN1 binds ATG5 and modulates the ATG5-NCOA4-FTH1 axis, affecting autophagosome formation, ferritin degradation, Fe2+ accumulation, and ferroptotic injury."	0.7006
38372097	"Cellular and molecular biology (Noisy-le-Grand, France)"	2024	Exosomal circMACF1 drives PI3K/AKT/mTOR-mediated autophagy suppression in laryngeal squamous cell carcinoma.	hsa_circ_0011773	circMACF1 	hsa_circ_MACF1	MACF1	laryngeal squamous cell carcinoma 	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR	"In this study, hsa_circ_0011773/circMACF1 was upregulated in LSCC tissues, serum, cells, and LSCC cell-derived exosomes. Exosomal circMACF1 promoted LSCC proliferation, migration, invasion, and tumor growth by suppressing autophagy through activation of the PI3K/AKT/mTOR pathway and positive regulation of its host gene MACF1. These findings suggest circMACF1 may serve as a therapeutic target for LSCC."	0.7889
38372878	Molecular biotechnology	2025	CircSCMH1 Accelerates Sorafenib Resistance in Hepatocellular Carcinoma by Regulating HN1 Expression via miR-485-5p.		circSCMH1 	hsa_circ_SCMH1	SCMH1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circSCMH1 is up-regulated in sorafenib-resistant HCC tissues and cells. It promotes sorafenib resistance and malignant phenotypes by acting as a ceRNA for miR-485-5p, thereby upregulating HN1; circSCMH1 knockdown increases sorafenib sensitivity in vitro and in a Huh7/SOR xenograft model."	0.8443
38376577	Biochemical genetics	2024	Circ-RNF111 Promotes Proliferation of Ovarian Cancer Cell SKOV-3 by Targeting the MiR-556-5p/CCND1 Axis.		circ-RNF111	hsa_circ_RNF111	RNF111	ovarian cancer	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circ-RNF111 is up-regulated in SKOV-3 ovarian cancer cells compared with IOSE80 cells. It promotes SKOV-3 cell proliferation and viability by sponging miR-556-5p and increasing CCND1 expression, suggesting a potential therapeutic target role in ovarian cancer."	0.5554
38376578	Biochemical genetics	2024	"Circ-Luc7l Absence Attenuates Diabetic Nephropathy Progression by Reducing Mesangial Cell Excessive Proliferation, Inflammation, and Extracellular Matrix Accumulation via Mediating the miR-205-5p/Tgfbr1 Pathway."	mmu_circ_0000734	circ-Luc7l	mmu_circ_Luc7l	Luc7l	Diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"circ-Luc7l is up-regulated in high glucose-treated mouse mesangial cells and promotes DN-related mesangial cell proliferation, inflammatory cytokine production, ECM accumulation, and renal fibrosis. Mechanistically, circ-Luc7l sponges miR-205-5p to increase Tgfbr1 expression, and circ-Luc7l knockdown alleviates DN phenotypes in vitro and in db/db mice."	0.7825
38376663	Molecular and cellular biochemistry	2024	Circ_0004872 deficiency attenuates ox-LDL-induced vascular smooth muscle cell dysfunction by miR-424-5p-dependent regulation of FRS2.	hsa_circ_0004872	circ_0004872	hsa_circ_MAPK1	MAPK1	Atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"circ_0004872 is up-regulated in serum from AS patients and in ox-LDL-treated VSMCs. It promotes ox-LDL-induced VSMC proliferation, invasion and migration by sponging miR-424-5p and increasing FRS2 expression, suggesting diagnostic and therapeutic relevance in AS."	0.817
38378118	International journal of biological macromolecules	2024	CircMLH3 induces mononuclear macrophage pyroptosis in sepsis by sponging miR-590-3p to regulate TAK1 expression.		circMLH3	hsa_circ_MLH3	MLH3	sepsis 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR; RNA-seq	"circMLH3 is up-regulated in the blood of patients with sepsis and is associated with diagnosis, 28-day mortality prediction, and poorer survival. Functionally, circMLH3 promotes mononuclear macrophage pyroptosis and inflammatory responses by sponging miR-590-3p to regulate TAK1, thereby influencing pro-caspase-1 activation and the NLRP3 inflammasome."	0.879
38378131	Gene	2024	Circular RNA Circ_0000119 promotes gastric cancer progression via circ_0000119/miR-502-5p/MTBP axis.	hsa_circ_0000119	circ_0000119	hsa_circ_MAN1A2	MAN1A2	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circ_0000119 is an exonic MAN1A2-derived circRNA that is up-regulated in gastric cancer tissues and cell lines. It promotes gastric cancer cell proliferation, migration, tumor growth and lung metastasis by sponging miR-502-5p and increasing MTBP expression. The study suggests circ_0000119 silencing may be a therapeutic strategy for GC patients."	0.8138
38378275	Chemical biology & drug design	2024	"IGF2BP3 loss inhibits cell progression by upregulating has_circRNA_103820, and hsa_circRNA_103820-encoded peptide inhibits cell progression by inactivating the AKT pathway in lung cancer."	hsa_circ_0072309	hsa_circRNA_103820 	hsa_circ_LIFR	LIFR	lung cancer 	MONDO:0008903	lung cancer	unknown	RT-qPCR	"This study identifies hsa_circRNA_103820 as a suppressive circRNA in lung cancer cell progression. IGF2BP3 binds hsa_circRNA_103820 in an m6A-dependent manner and negatively regulates its expression, while hsa_circRNA_103820 encodes a functional 188-aa peptide that inhibits LC cell viability, migration and invasion and promotes apoptosis through inhibition of the AKT/PI3K/mTOR pathway."	0.6945
38386274	Molecular biotechnology	2025	Circ_0007351 Exerts an Oncogenic Role In Colorectal Cancer Depending on the Modulation of the miR-5195-3p/GPRC5A Cascade.	hsa_circ_0007351	circ_0007351 	hsa_circ_AGTPBP1	AGTPBP1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0007351 is a human AGTPBP1-derived circRNA that is up-regulated in colorectal cancer tissues and cell lines. It promotes colorectal cancer cell proliferation, motility, invasion and xenograft tumor growth by sponging miR-5195-3p and thereby increasing GPRC5A expression. The study suggests that inhibiting circ_0007351 may have therapeutic potential for colorectal cancer."	0.7552
38394688	Angiology	2025	"CircCDYL Contributes to Apoptosis, Ferroptosis, and Oxidative Stress of Ang II-Induced Vascular Smooth Muscle Cells in Thoracic Aortic Aneurysm."	hsa_circ_0008285	circCDYL 	hsa_circ_CDYL	CDYL	thoracic aortic aneurysm 	MONDO:0005396	thoracic aortic aneurysm	up-regulated	RT-qPCR	"circCDYL is up-regulated in TAA tissues and Ang II-treated human VSMCs. It promotes Ang II-induced VSMC injury by inhibiting viability/proliferation and enhancing apoptosis, ferroptosis, and oxidative stress. Mechanistically, circCDYL acts as a sponge for miR-1270 to positively regulate ADAM10, suggesting the circCDYL/miR-1270/ADAM10 axis as a potential therapeutic target in TAA."	0.8111
38400886	Digestive diseases and sciences	2024	Circular RNA CircSLC22A23 Promotes Gastric Cancer Progression by Activating HNRNPU Expression.	hsa_circ_0075504	CircSLC22A23 	hsa_circ_SLC22A23	SLC22A23	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circSLC22A23 is up-regulated in gastric cancer tissues, plasma, and cell lines and high expression is associated with vascular invasion and worse prognosis. Functionally, circSLC22A23 promotes GC cell proliferation, migration, and invasion. Mechanistically, it binds HNRNPU and activates EGFR expression, supporting an oncogenic circSLC22A23-HNRNPU-EGFR regulatory mechanism."	0.8632
38401744	Toxicology in vitro : an international journal published in association with BIBRA	2024	Hsa_circ_0003356 suppresses gastric cancer progression via miR-556-5p/FKBP5 axis.	hsa_circ_0003356	Circ_0003356 	hsa_circ_PPP5C	PPP5C	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0003356/circ_0003356 is down-regulated in gastric cancer tissues and cell lines and is associated with favorable prognosis when expressed at higher levels. Functionally, circ_0003356 suppresses GC progression by sponging miR-556-5p and increasing FKBP5, thereby inhibiting proliferation, migration, invasion and tumor growth while promoting apoptosis."	0.8823
38402995	Brain research bulletin	2024	Integrated analysis of circRNA- related ceRNA network targeting neuroinflammation in medial temporal lobe epilepsy.	hsa_circ_0005145		hsa_circ_OTULIN	OTULIN	medial temporal lobe epilepsy 	MONDO:0005115	temporal lobe epilepsy	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0005145 was identified from a human mTLE circRNA-related ceRNA network and was implicated as an up-regulated circRNA. The study proposes and experimentally supports a hsa_circ_0005145/hsa-miR-149-5p/IL-1alpha regulatory axis that may promote neuroinflammation in mTLE and serve as a potential therapeutic target.	0.4474
38402995	Brain research bulletin	2024	Integrated analysis of circRNA- related ceRNA network targeting neuroinflammation in medial temporal lobe epilepsy.		mmu-Otulin_0005	mmu_circ_Otulin	Otulin	epilepsy	MONDO:0005027	epilepsy	up-regulated	RT-qPCR	"mmu-Otulin_0005 was used as a mouse-derived homologous circRNA node in the mouse-specific hub ceRNA network. Its expression was significantly increased in the Sombati epilepsy cell model, supporting its involvement in the circRNA-miRNA-mRNA network associated with IL-1alpha-related neuroinflammatory regulation."	0.1768
38409882	Biotechnology and applied biochemistry	2024	Hsa_circ_0001480 affects osteosarcoma progression by regulating the miR-363-3p/IBSP pathway.	hsa_circ_0001480	circ_0001480 	hsa_circ_NTT	NTT	Osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"hsa_circ_0001480/circ_0001480 is upregulated in osteosarcoma tissues and cell lines and acts as an oncogenic circRNA. It promotes OS cell proliferation, invasion, and xenograft tumor growth by sponging miR-363-3p and modulating the downstream target IBSP, suggesting potential therapeutic relevance."	0.7795
38410923	Epigenomics	2024	hsa_circ_0087100/hsa-miR-6743-5p affects Th1 cell differentiation by regulating STAT1 in diabetic retinopathy.	hsa_circ_0087100	hsa circ 0087100	hsa_circ_CNTNAP3	CNTNAP3	diabetic retinopathy 	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR; Microarray	"hsa_circ_0087100 is up-regulated in high-glucose-treated HRMECs and in blood samples from diabetic retinopathy patients. The study identifies hsa circ 0087100-hsa-miR-6743-5p-STAT1 as the key ceRNA axis associated with immune regulation in DR, potentially promoting STAT1-mediated Th1 cell differentiation and immune infiltration."	0.6521
38411943	Biochemical genetics	2025	Circ_BLNK is a Unique Molecular Marker in Non-small Cell Lung Cancer.		Circ_BLNK 	hsa_circ_BLNK	BLNK	Non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"circ_BLNK is down-regulated in NSCLC tissues and cells and behaves as a tumor suppressor. Its overexpression inhibits malignant phenotypes and xenograft tumor growth by sponging miR-942-5p and relieving repression of FOXO1, forming a circ_BLNK/miR-942-5p/FOXO1 regulatory axis with potential diagnostic and therapeutic relevance."	0.7955
38412628	Chemico-biological interactions	2024	Circ DENND4C inhibits pyroptosis and alleviates ischemia-reperfusion acute kidney injury by exosomes secreted from human urine-derived stem cells.		Circ DENND4C 	hsa_circ_DENND4C	DENND4C	Acute kidney injury 	MONDO:0002492	acute kidney injury	down-regulated	RT-qPCR; RNA-seq	"Circ DENND4C is decreased in ischemia-reperfusion AKI and is enriched in human USC-derived exosomes. Exosomal circ DENND4C protects against renal I/R injury by sponging miR 138-5p and regulating FOXO3a, which promotes cell proliferation and suppresses NLRP3-associated pyroptosis and inflammation."	0.6829
38412628	Chemico-biological interactions	2024	Circ DENND4C inhibits pyroptosis and alleviates ischemia-reperfusion acute kidney injury by exosomes secreted from human urine-derived stem cells.		Circ DENND4C 	rno_circ_DENND4C	DENND4C	Acute kidney injury 	MONDO:0002492	acute kidney injury	down-regulated	RT-qPCR; RNA-seq	"Circ DENND4C is decreased in ischemia-reperfusion AKI and is enriched in human USC-derived exosomes. Exosomal circ DENND4C protects against renal I/R injury by sponging miR 138-5p and regulating FOXO3a, which promotes cell proliferation and suppresses NLRP3-associated pyroptosis and inflammation."	0.6829
38412628	Chemico-biological interactions	2024	Circ DENND4C inhibits pyroptosis and alleviates ischemia-reperfusion acute kidney injury by exosomes secreted from human urine-derived stem cells.		circ PHLPP1 	rno_circ_PHLPP1	PHLPP1	Acute kidney injury 	MONDO:0002492	acute kidney injury	down-regulated	RT-qPCR; RNA-seq	"circPHLPP1 was significantly reduced in ischemia-reperfusion-injured rat kidneys and was confirmed by real-time PCR. The study did not investigate its mechanism or functional role in AKI, and the authors proposed future research to define its regulatory pathways."	0.2465
38412676	International immunopharmacology	2024	Hsa_circ_0036872 has an important promotional effect in enhancing osteogenesis of dental pulp stem cells by regulating the miR-143-3p/IGF2 axis.	hsa_circ_0036872		hsa_circ_FURIN	FURIN	osteoporosis 	MONDO:0005298	osteoporosis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0036872 is up-regulated during osteogenic differentiation of human dental pulp stem cells and promotes their osteogenic differentiation and heterotopic bone formation. Mechanistically, it acts through the miR-143-3p/IGF2 axis and the IGF2 signalling pathway, suggesting potential value for osteoporosis treatment and bone/periodontal regeneration."	0.7769
38417635	Cellular signalling	2024	mm9_circ_014683 regulates microglia polarization through canonical NFkappaB signaling pathway in diabetic retinopathy.	mmu_circ_0000381	mm9_circ_014683 		2700097O09Rik	diabetic retinopathy 	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR; ISH; RNA-seq	"This study identifies mm9_circ_014863/mm9_circ_014683 as an up-regulated mouse circRNA in high-glucose-treated microglia and retinal microglia from diabetic mice. Functionally, it promotes pro-inflammatory M1 microglial polarization and suppresses M2 polarization through activation of the canonical NFkappaB pathway, suggesting a potential therapeutic role in diabetic retinopathy."	0.7068
38421140	Andrology	2024	A detection model of testis-derived circular RNAs in serum for predicting testicular sperm retrieval rate in non-obstructive azoospermia patients.	hsa_circ_0058058	circATIC	hsa_circ_ATIC	ATIC	non-obstructive azoospermia 	MONDO:0100459	azoospermia	up-regulated	RT-qPCR	hsa_circ_0058058 was significantly higher in serum from NOA patients with failed sperm retrieval than in those with successful retrieval. It served as an independently predictive serum circRNA biomarker for sperm retrieval rate and was included in the best-performing six-circRNA prediction panel.	0.459
38421140	Andrology	2024	A detection model of testis-derived circular RNAs in serum for predicting testicular sperm retrieval rate in non-obstructive azoospermia patients.	hsa_circ_0008045	circMGLL	hsa_circ_MGLL	MGLL	non-obstructive azoospermia 	MONDO:0100459	azoospermia	up-regulated	RT-qPCR	hsa_circ_0008045 was significantly higher in serum from NOA patients with failed sperm retrieval than in those with successful retrieval. It had strong diagnostic/predictive performance as an independent single-circRNA panel and contributed to the six-circRNA model for predicting SRR.	0.459
38421140	Andrology	2024	A detection model of testis-derived circular RNAs in serum for predicting testicular sperm retrieval rate in non-obstructive azoospermia patients.	hsa_circ_0084789	circZFHX4	hsa_circ_ZFHX4	ZFHX4	non-obstructive azoospermia 	MONDO:0100459	azoospermia	up-regulated	RT-qPCR	hsa_circ_0084789 was significantly higher in serum from NOA patients with failed sperm retrieval. It had the highest single-circRNA AUC among the six circRNAs and was incorporated into the combined serum circRNA prediction model for SRR.	0.459
38421140	Andrology	2024	A detection model of testis-derived circular RNAs in serum for predicting testicular sperm retrieval rate in non-obstructive azoospermia patients.	hsa_circ_0000550	circSLC10A1	hsa_circ_SLC10A1	SLC10A1	non-obstructive azoospermia 	MONDO:0100459	azoospermia	up-regulated	RT-qPCR	hsa_circ_0000550 was significantly higher in serum from NOA patients with failed sperm retrieval. It showed independent predictive value for SRR and formed part of the six-circRNA risk-score model.	0.459
38421140	Andrology	2024	A detection model of testis-derived circular RNAs in serum for predicting testicular sperm retrieval rate in non-obstructive azoospermia patients.	hsa_circ_0007422	circSATB2	hsa_circ_SATB2	SATB2	non-obstructive azoospermia 	MONDO:0100459	azoospermia	down-regulated	RT-qPCR	hsa_circ_0007422 was significantly lower in serum from NOA patients with failed sperm retrieval. Higher serum expression was associated with successful sperm retrieval and it showed diagnostic/predictive utility both alone and within the six-circRNA panel.	0.459
38421140	Andrology	2024	A detection model of testis-derived circular RNAs in serum for predicting testicular sperm retrieval rate in non-obstructive azoospermia patients.	hsa_circ_0004099	circDENND5A	hsa_circ_DENND5A	DENND5A	non-obstructive azoospermia 	MONDO:0100459	azoospermia	down-regulated	RT-qPCR	"hsa_circ_0004099 was significantly lower in serum from NOA patients with failed sperm retrieval. Higher serum expression was associated with successful sperm retrieval, and the circRNA contributed to the multi-circRNA SRR prediction panel; bioinformatics linked it to pathways involving TCF7L2, NRAS, CTNNB1, and KRAS."	0.459
38421527	Journal of bioenergetics and biomembranes	2024	Knockdown of circ_0044226 promotes endoplasmic reticulum stress-mediated autophagy and apoptosis in hepatic stellate cells via miR-4677-3p/SEC61G axis.	hsa_circ_0044226	circ_0044226	hsa_circ_CDC27	CDC27	liver fibrosis	MONDO:0100430	fibrotic liver disease	up-regulated	RT-qPCR	"circ_0044226 is up-regulated in liver fibrosis models and supports activated hepatic stellate cell proliferation and survival. Its knockdown releases miR-4677-3p to suppress SEC61G, enhancing endoplasmic reticulum stress and promoting autophagy and apoptosis, thereby attenuating CCL4-induced liver fibrosis in mice."	0.5607
38422649	Phytomedicine : international journal of phytotherapy and phytopharmacology	2024	Qingjie Huagong decoction inhibits pancreatic acinar cell pyroptosis by regulating circHipk3/miR-193a-5p/NLRP3 pathway.	mmu_circ_0009139	circHipk3 	mmu_circ_Hipk3	Hipk3	acute pancreatitis 	MONDO:0006515	acute pancreatitis	up-regulated	RT-qPCR	"In this study, mouse circHipk3 was up-regulated in caerulein-induced acute pancreatitis models. circHipk3 acted as a ceRNA sponge for miR-193a-5p to promote NLRP3 inflammasome activation, pyroptosis, and inflammatory responses; QJHGD and circHipk3 silencing alleviated pancreatic acinar cell injury through this pathway."	0.705
38423246	Cancer letters	2024	"CircUBE3A(2,3,4,5) promotes adenylate-uridylate-rich binding factor 1 nuclear translocation to suppress prostate cancer metastasis."	hsa_circ_0000586	"circUBE3A(2,3,4,5) "	hsa_circ_UBE3A	UBE3A	prostate cancer 	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; ISH; RNA-seq; Microarray	"circUBE3A(2,3,4,5) is a human UBE3A-derived circRNA downregulated in prostate cancer tissues and associated with more aggressive clinicopathological features. It acts as a tumor suppressor by binding AUF1, promoting AUF1 nuclear translocation, destabilizing MTHFD2 mRNA, lowering MTHFD2 and vimentin expression, and thereby inhibiting proliferation, migration, invasion, EMT, and metastasis."	0.8729
38424136	Leukemia	2024	circFAM193B interaction with PRMT6 regulates AML leukemia stem cells chemoresistance through altering the oxidative metabolism and lipid peroxidation.	hsa_circ_0002972	circFAM193B	hsa_circ_FAM193B	FAM193B	acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	down-regulated	RT-qPCR; Microarray	"circFAM193B is a FAM193B-derived circRNA downregulated in AML LSCs, AML bone marrow blasts, and relapse-stage samples. In this study, circFAM193B suppresses AML LSC maintenance and chemoresistance by interacting with PRMT6, reducing H3R2me2a deposition at the ALOX15 promoter, and promoting ALOX15-linked lipid peroxidation and oxidative stress-induced cell death. Clinically, low circFAM193B expression is associated with AML relapse and poorer survival, whereas high expression is associated with better survival."	0.8871
38427129	Journal of bioenergetics and biomembranes	2024	CircACTR2 attenuated the effects of tetramethylpyrazine on human kidney cell injury.		circRNA_102747 	hsa_circ_ACTR2	ACTR2	diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"In a high glucose-induced HK-2 cell model of diabetic nephropathy, circACTR2 was up-regulated and was suppressed by tetramethylpyrazine treatment. circACTR2 overexpression weakened the protective effects of tetramethylpyrazine by sponging miR-140-5p and increasing GLIPR2, thereby promoting apoptosis, oxidative stress, and inflammatory cytokine production."	0.6562
38427179	Molecular biotechnology	2025	Silencing circLDLRAD3 Inhibits Lung Cancer Progression by Regulating the miR-497-5p/PFKP Axis.	hsa_circ_0006988	circLDLRAD3 	hsa_circ_LDLRAD3	LDLRAD3	lung cancer 	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circLDLRAD3 is up-regulated in lung cancer tissues and cells and is associated with more aggressive clinicopathologic features. Functionally, circLDLRAD3 promotes lung cancer cell proliferation, migration, invasion, glycolysis and xenograft tumor growth while suppressing apoptosis. Mechanistically, it acts as a miR-497-5p sponge to increase PFKP expression, suggesting the circLDLRAD3/miR-497-5p/PFKP axis as a potential therapeutic target."	0.8299
38428311	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2024	Exosomal hsa_circ_0093884 derived from endothelial progenitor cells promotes therapeutic neovascularization via miR-145/SIRT1 pathway.	hsa_circ_0093884		hsa_circ_SIRT1	SIRT1	ischemic diseases 	MONDO:0005053	ischemic disease	unknown	RT-qPCR; ISH	"This study identifies hsa_circ_0093884 as a SIRT1-derived exosomal circRNA enriched in endothelial progenitor cell-derived exosomes. Exosomal hsa_circ_0093884 promotes therapeutic neovascularization by enhancing endothelial proliferation, migration and angiogenesis while reducing hypoxia-induced apoptosis. Mechanistically, it acts as a cytoplasmic sponge for miR-145, relieving repression of SIRT1 through the hsa_circ_0093884/miR-145/SIRT1 axis."	0.8165
38430026	"Cellular and molecular biology (Noisy-le-Grand, France)"	2024	CircSCUBE3 promoted ferroptosis to inhibit lung adenocarcinoma progression.	hsa_circ_0076092		hsa_circ_SCUBE3	SCUBE3	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; Microarray	"circSCUBE3 is downregulated in LUAD tissues and cell lines. Functionally, it suppresses LUAD cell viability and xenograft tumorigenesis by promoting ferroptosis. Mechanistically, circSCUBE3 binds CREB and inhibits CREB-mediated GPX4 transcription, thereby affecting GPX4-mediated GSH synthesis through the CREB/GPX4/GSH axis."	0.8438
38430028	"Cellular and molecular biology (Noisy-le-Grand, France)"	2024	Declined circular RNA mitofusin 2 constrains the deterioration of Wilms tumor via modulating microRNA-372-3p/transforming growth factor-beta receptor type 2 axis.			hsa_circ_MFN2	MFN2	Wilms tumor 	MONDO:0006058	Wilms tumor	up-regulated	RT-qPCR	"In this study, circRNA MFN2 was up-regulated in Wilms tumor tissues and WiT49 cells. Functional assays showed that knockdown of circRNA MFN2 suppressed WT cell proliferation, migration and invasion and promoted apoptosis. Mechanistically, circRNA MFN2 modulated the miR-372-3p/TGFBR2 axis, supporting its potential role as a diagnostic or therapeutic marker for WT."	0.7591
38430029	"Cellular and molecular biology (Noisy-le-Grand, France)"	2024	Circ-LDLRAD3/miR-655-3p/MAPK1 axis enhances cell migration and invasion in papillary thyroid carcinoma.			hsa_circ_LDLRAD3	LDLRAD3	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circ-LDLRAD3 is up-regulated in PTC tissues and cell lines and is associated with tumor size, TNM stage, and lymph node metastasis. Functionally, circ-LDLRAD3 promotes PTC cell proliferation, migration, invasion and resistance to apoptosis. Mechanistically, it sponges miR-655-3p to increase MAPK1 expression, forming a circ-LDLRAD3/miR-655-3p/MAPK1 ceRNA axis."	0.6536
38430033	"Cellular and molecular biology (Noisy-le-Grand, France)"	2024	Circular RNA circ_0096041 promotes osteosarcoma cell proliferation and migration via sponging miR-556-5p and regulating LIN28A expression.	hsa_circ_0096041	circ_0096041			osteosarcoma	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ_0096041 is up-regulated in osteosarcoma tissues and cells and acts as an oncogenic circRNA. It promotes proliferation, migration, and in vivo metastasis by sponging miR-556-5p and increasing LIN28A/cMYC/Ras signaling, and its high expression is associated with worse prognosis and advanced stage."	0.7528
38431178	Experimental gerontology	2024	CircHIVEP2 alleviates Parkinson's nerve damage and inflammatory response by targeting miR-485-3p.	hsa_circ_0007021	circHIVEP2 	hsa_circ_HIVEP2	HIVEP2	Parkinson's disease 	MONDO:0005180	Parkinson disease	down-regulated	RT-qPCR	"circHIVEP2 is down-regulated in serum from Parkinson's disease patients and in MPP+-induced SH-SY5Y cells. Its overexpression protects against MPP+-induced cellular injury by increasing viability and suppressing apoptosis and inflammatory cytokine release, at least partly through direct binding and inhibition of miR-485-3p. Clinically, serum circHIVEP2 shows diagnostic potential for distinguishing PD patients from healthy controls."	0.7718
38433354	Autophagy	2024	Lopinavir enhances anoikis by remodeling autophagy in a circRNA-dependent manner.	hsa_circ_0000745	circSPECC1	hsa_circ_SPECC1	SPECC1	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; ISH	"CircSPECC1 is downregulated in gastric cancer and acts as an anti-metastatic circRNA by binding ATG4B and RNF5, promoting ATG4B phase separation, ubiquitination and degradation. Its loss increases ATG4B-mediated autophagy and anoikis resistance, while lopinavir restores circSPECC1 by blocking ELAVL1/HuR-mediated repression, thereby enhancing anoikis and reducing metastasis. Low circSPECC1 expression is associated with advanced disease features and poor survival."	0.837
38438030	The Science of the total environment	2024	A unique circ_0067716/EIF4A3 double-negative feedback loop impacts malignant transformation of human bronchial epithelial cells induced by benzo(a)pyrene.	hsa_circ_0067716	circ_0067716	hsa_circ_RNF13	RNF13	lung cancer 	MONDO:0008903	lung cancer	down-regulated	RT-qPCR; RNA-seq	"circ_0067716 is a human RNF13-derived circRNA that is upregulated during acute BPDE-induced stress injury but downregulated during malignant transformation and in lung cancer tissues. It promotes apoptosis via the miR-324-5p/DRAM1/BAX/caspase 3 axis, while its loss facilitates malignant transformation and proliferation through EIF4A3-mediated stabilization of PI3K mRNA and activation of PI3K/AKT signaling. Clinically, lower circ_0067716 expression is associated with smoking-related lung cancer features including smoking status, tumor size, TNM stage, and BPDE-DNA adduct burden."	0.8343
38438055	Gene	2024	Circ1811 suppresses gastric cancer progression by regulating the miR-632/DAPK1 axis.	hsa_circ_0001811	circ1811 	hsa_circ_STAU2	STAU2	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"circ1811 is a human STAU2-derived circRNA that is down-regulated in gastric cancer tissues. It acts as a tumor suppressor by inhibiting proliferation, migration and invasion, promoting apoptosis, and reducing xenograft tumor growth. Mechanistically, circ1811 sponges miR-632 to relieve repression of DAPK1 mRNA, forming the circ1811/miR-632/DAPK1 axis, and its low expression is associated with lymphatic metastasis and potential diagnostic/therapeutic value."	0.879
38438090	Pharmacological research	2024	CircBIRC6 facilitates the malignant progression via miR-488/GRIN2D-mediated CAV1-autophagy signal axis in gastric cancer.	hsa_circ_0053441	circRNA BIRC6 	hsa_circ_BIRC6	BIRC6	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circBIRC6 is up-regulated in gastric cancer and predicts poor overall survival. It promotes proliferation, migration, invasion, and tumor growth by sponging miR-488, increasing GRIN2D and CAV1 expression, and inhibiting autophagy, making it a potential therapeutic target and independent prognostic factor."	0.8897
38438754	Molecular biotechnology	2025	Circ_0082374 Promotes the Tumorigenesis and Suppresses Ferroptosis in Non-small Cell Lung Cancer by Up-Regulating GPX4 Through Sequestering miR-491-5p.	hsa_circ_0082374	circ_0082374	hsa_circ_CPA4	CPA4	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0082374 is up-regulated in NSCLC tissues and cells. It promotes NSCLC proliferation, metastasis, EMT and in vivo tumor growth while suppressing ferroptosis. Mechanistically, circ_0082374 functions as a ceRNA that sponges miR-491-5p to increase GPX4 expression."	0.8006
38447057	"The journals of gerontology. Series A, Biological sciences and medical sciences"	2024	Circular RNA CircVmn2r1 Acts as a miR-223-3p Sponge to Promote Kidney Aging by Regulating NLRP3 Expression in Mice.	mmu_circ_0010759	CircVmn2r1	mmu_circ_Vmn2r1	vmn2r1	kidney aging 			up-regulated	RT-qPCR; RNA-seq	"circVmn2r1 is a mouse kidney circRNA upregulated in aged kidney tissue. It promotes kidney aging and TCMK-1 cell senescence while inhibiting proliferation, acting mechanistically as a miR-223-3p sponge that relieves repression of NLRP3 and increases NLRP3 expression."	0.7548
38449057	"Advances in rheumatology (London, England)"	2024	"Tetramethylpyrazine alleviates hypoxia-induced proliferation, migration, and inflammatory response of fibroblast-like synoviocytes via inhibiting the HIF-1alpha- circCDC42BPB pathway."	hsa_circ_0005178	circCDC42BPB	hsa_circ_CDC42BPB	CDC42BPB	Rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0005178/circCDC42BPB is up-regulated in RA patients and hypoxia-treated RA-FLSs and is reduced by TMP treatment. Functionally, circCDC42BPB promotes hypoxia-induced RA-FLS proliferation, cell cycle progression, migration, and inflammatory responses, counteracting TMP-mediated protection. Mechanistically, HIF-1alpha promotes circCDC42BPB transcription via the CDC42BPB promoter, forming a TMP/HIF-1alpha/circCDC42BPB regulatory axis with potential diagnostic and therapeutic relevance in RA."	0.8256
38456718	Acta cardiologica	2024	Serum circRNA (Circ)_0051386 assists in the diagnosis of acute ST-segment elevation myocardial infarction and prediction of the occurrence of major adverse cardiovascular events after percutaneous coronary intervention.	hsa_circ_0051386	Circ_0051386 			acute ST-segment elevation myocardial infarction 	MONDO:0041656	ST-elevation myocardial infarction	up-regulated	RT-qPCR; Microarray	"Circ_0051386 was identified by microarray-based bioinformatics and random forest analysis and validated by RT-qPCR as up-regulated in serum from STEMI patients. Its elevated serum level showed diagnostic value for STEMI and independently predicted MACEs after PCI. The study also found positive correlations with IL-1beta and TNF-alpha, suggesting a potential role in vascular endothelial inflammation."	0.6424
38458026	Reproductive biology	2024	Circ_0001495 influences the development of endometriosis through the miRNA-34c-5p/E2F3 axis.	hsa_circ_0001495	circ_0001495 	hsa_circ_CCNB1	CCNB1	endometriosis 	MONDO:0005133	endometriosis	up-regulated	RT-qPCR	"circ_0001495 is up-regulated in endometriosis tissues, serum, and ectopic endometrial stromal cells. It promotes EESC proliferation, migration, and invasion while suppressing apoptosis, and it exacerbates endometriosis progression through the miR-34c-5p/E2F3 ceRNA axis. The study suggests circ_0001495 as a potential therapeutic target for endometriosis."	0.6545
38458967	Chemical biology & drug design	2024	Brucine alleviates fibroblast-like synoviocytes dysfunction and inflammation by regulating YY1 during rheumatoid arthritis.	hsa_circ_0139658	circ_0139658	hsa_circ_LAMP2	LAMP2	rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"hsa_circ_0139658 is up-regulated in RA synovial tissues and RA-FLSs. It promotes RA-FLS proliferation, migration, invasion, inflammatory cytokine production, and macrophage M1 polarization while suppressing apoptosis, at least partly through the circ_0139658/miR-653-5p/YY1 axis. Brucine alleviates RA-FLS dysfunction and inflammation by suppressing this circRNA-mediated YY1 regulation."	0.8175
38459187	British journal of cancer	2024	EIF4A3-negatively driven circular RNA beta-catenin (circbeta-catenin) promotes colorectal cancer progression via miR-197-3p/CTNND1 regulatory axis.	hsa_circ_0004194	circbeta-catenin 	hsa_circ_CTNNB1	CTNNB1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circbeta-catenin (hsa_circ_0004194) is an up-regulated CTNNB1-derived circRNA in CRC tissues and cells. It promotes CRC proliferation, tumor growth, invasion and metastasis by sponging miR-197-3p and relieving repression of CTNND1, while EIF4A3 negatively regulates its biogenesis through interaction with IRAlus. Clinically, high circbeta-catenin expression is associated with advanced TNM stage, lymph node involvement and distant metastasis, suggesting prognostic and therapeutic relevance."	0.8512
38459420	Apoptosis : an international journal on programmed cell death	2024	Circ_0098823 binding with IGF2BP3 regulates DNM1L stability to promote metastasis of hepatocellular carcinoma via mitochondrial fission.	hsa_circ_0098823	circ_0098823	hsa_circ_ERBB3	ERBB3	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0098823 is an ERBB3-derived circRNA that is up-regulated in HCC tissues and HGF-induced HCC cell lines. It promotes HCC cell viability, migration, invasion, tumor growth and metastasis while suppressing apoptosis, at least partly by binding IGF2BP3 to stabilize DNM1L mRNA and enhance mitochondrial fission. Its expression also showed diagnostic potential for distinguishing HCC from normal controls."	0.8711
38460628	International journal of biological macromolecules	2024	CircNOP14 increases the radiosensitivity of hepatocellular carcinoma via inhibition of Ku70-dependent DNA damage repair.	hsa_circ_0006737	circNOP14 	hsa_circ_NOP14	NOP14	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circNOP14 is a stable cytoplasmic circRNA derived from NOP14 and is upregulated in HCC after 125 I seed irradiation. It enhances radiosensitivity to both 125 I brachytherapy and external radiation by binding Ku70, blocking Ku70 nuclear import, inhibiting DNA damage repair, and increasing radiation-induced DNA damage and apoptosis. Clinically, higher circNOP14 expression is associated with better objective response and short-term efficacy in HCC patients receiving 125 I seed implantation therapy."	0.8561
38463586	American journal of translational research	2024	Expression of circular RNA has-circ-0009158 and identification of associated miRNA-mRNA network in hepatocellular carcinoma.	hsa_circ_0009158		hsa_circ_ASPH	ASPH	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"hsa-circ-0009158 is up-regulated in HCC tissues and HCC cell lines. Its high expression is associated with adverse clinicopathological features, recurrence, shorter RFS, and poor OS, indicating prognostic biomarker potential. Bioinformatic analyses suggest a hsa-circ-0009158-associated hsa-miR-942-mRNA network involving 248 mRNAs and cell cycle-related processes."	0.5121
38467376	Biochemical pharmacology	2024	Phytic acid promotes high glucose-mediated bone marrow mesenchymal stem cells osteogenesis via modulating circEIF4B that sponges miR-186-5p and complexes with IGF2BP3.	hsa_circ_0026506	circEIF4B	hsa_circ_EIF4B	EIF4B	diabetes-related hyperglycemia 	MONDO:0005015	diabetes mellitus	down-regulated	RT-qPCR; Microarray	"In high-glucose BMSCs, circEIF4B is reduced, while PA treatment restores and upregulates its expression. circEIF4B promotes osteogenic differentiation and bone regeneration through two main mechanisms: sponging miR-186-5p to regulate FOXO1 and forming a complex with IGF2BP3 to stabilize ITGA5 mRNA. Knockdown of circEIF4B diminishes the osteogenic and bone-regenerative effects of PA in diabetic rat cranial defects."	0.8664
38470367	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2024	CircFOXO3 mediates hypoxia-induced autophagy of endometrial stromal cells in endometriosis.	hsa_circ_0006404	CircFOXO3 	hsa_circ_FOXO3	FOXO3	endometriosis 	MONDO:0005133	endometriosis	down-regulated	RT-qPCR	"CircFOXO3 is down-regulated in ectopic endometrium from endometriosis patients. In this study, circFOXO3 overexpression inhibited p53-mediated autophagy and reduced migration and invasion of T HESCs, while hypoxia-induced HIF-1alpha/ADAR1 signaling suppressed circFOXO3 formation and promoted endometriosis-related autophagy."	0.8187
38471264	Atherosclerosis	2024	Identification of circular RNA hsa_circ_0034621 as a novel biomarker for carotid atherosclerosis and the potential function as a regulator of NLRP3 inflammasome.	hsa_circ_0043621	hsa_-circ_0043621			carotid atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0043621 is up-regulated in carotid atherosclerosis and functions as a circulating diagnostic biomarker for CAP and increased IMT. Mechanistically, it sponges miR-223-3p to promote NLRP3 expression and NLRP3 inflammasome-related inflammation, while affecting endothelial proliferation and migration."	0.7617
38471264	Atherosclerosis	2024	Identification of circular RNA hsa_circ_0034621 as a novel biomarker for carotid atherosclerosis and the potential function as a regulator of NLRP3 inflammasome.	hsa_circ_0051995				carotid atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0051995 was identified by microarray screening and validated by RT-qPCR as up-regulated in CAP cases. It correlated positively with NLRP3 expression, but the tested miR-100-5p interaction was not validated and no functional role was established."	0.5135
38471264	Atherosclerosis	2024	Identification of circular RNA hsa_circ_0034621 as a novel biomarker for carotid atherosclerosis and the potential function as a regulator of NLRP3 inflammasome.	hsa_circ_0123388	hsa_-circ_0123388			carotid atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0123388 was identified by microarray screening and validated by RT-qPCR as up-regulated in CAP cases. Its predicted miR-124-3p interaction was not validated, and no downstream functional mechanism was established in this study."	0.5135
38472721	Journal of endocrinological investigation	2024	Hsa_circ_0008360 promotes high glucose-induced damage in HK-2 cells via miR-346/WNT2B axis.	hsa_circ_0008360	circ_0008360	hsa_circ_XPNPEP3	XPNPEP3	Diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"hsa_circ_0008360 is up-regulated in serum from diabetic nephropathy patients and in high glucose-treated HK2 cells. It promotes HG-induced renal tubular epithelial cell injury by sponging miR-346 and increasing WNT2B expression, thereby enhancing apoptosis, inflammation, and fibrosis while reducing cell viability. The study suggests hsa_circ_0008360 as a potential therapeutic target for DN."	0.8111
38482622	Current neurovascular research	2024	Whole Transcriptome Sequencing of Peripheral Blood Identifies the Alzheimer's Disease-Related circRNA-miRNA-lncRNA Pathway.	hsa_circ_0001170	hsa-circ-0001170 	hsa_circ_NFATC2	NFATC2	Alzheimer's disease 	MONDO:0004975	Alzheimer disease	up-regulated	RNA-seq	"hsa_circ_0001170 was identified as an upregulated circRNA in peripheral blood from AD patients with moderate dementia compared with normal cognition controls. The study proposes a circRNA-miRNA-lncRNA ceRNA pathway involving hsa_circ_0001170, hsa-miR-7-5p, and ADGRD1-AS1, suggesting potential relevance to AD pathogenesis and biomarker development."	0.4874
38485895	Journal of endocrinological investigation	2024	CircNRCAM up-regulates NRCAM to promote papillary thyroid carcinoma progression.	hsa_circ_0133006	circNRCAM 	hsa_circ_NRCAM	NRCAM	Papillary Thyroid Carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circNRCAM is up-regulated in papillary thyroid carcinoma cells and promotes PTC cell proliferation, invasion, and migration. Mechanistically, circNRCAM competitively binds ALKBH5, reduces pre-miR-506 stability and miR-506-3p expression, and thereby increases NRCAM expression to enhance malignant cellular behaviors."	0.7918
38489970	International immunopharmacology	2024	"CircRAPGEF5 sponges miR-582-3p and targets KIF3A to regulate bladder cancer cell proliferation, migration and invasion."	hsa_circ_0001681	CircRAPGEF5 	hsa_circ_RAPGEF5	RAPGEF5	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circRAPGEF5 is up-regulated in bladder cancer tissues and cell lines, and high expression is associated with poor overall survival, tumor size, and tumor stage. Functionally, circRAPGEF5 promotes BCa cell proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, it acts as a ceRNA by sponging miR-582-3p and up-regulating KIF3A."	0.8175
38492367	Phytomedicine : international journal of phytotherapy and phytopharmacology	2024	Multiomic study of the protective mechanism of Persicaria capitata (Buch.-Ham. ex D.Don) H.Gross against streptozotocin-induced diabetic nephropathy in Guizhou miniature pigs.		novel_circ_0001514 	ssc_circ_NEMF	NEMF	diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	dysregulated	RT-qPCR; RNA-seq	"novel_circ_0001514 is a pig kidney circRNA identified by RNA sequencing and validated by qPCR as differentially expressed in the streptozotocin-induced DN model and restored after P. capitata treatment. It is linked to the NEMF source gene and predicted miRNA binding, suggesting a role in the multiomic protective mechanism of P. capitata against DN."	0.4997
38492367	Phytomedicine : international journal of phytotherapy and phytopharmacology	2024	Multiomic study of the protective mechanism of Persicaria capitata (Buch.-Ham. ex D.Don) H.Gross against streptozotocin-induced diabetic nephropathy in Guizhou miniature pigs.		novel_circ_0017507 	ssc_circ_GLUL	GLUL	diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	dysregulated	RT-qPCR; RNA-seq	"novel_circ_0017507 is a pig kidney circRNA identified by RNA sequencing and validated by qPCR as differentially expressed in the DN model and restored after P. capitata treatment. It is associated with the GLUL source gene, coexpressed lncRNAs, and predicted binding sites for 14 miRNAs, supporting its role as a multiomic node in the protective mechanism of P. capitata against DN."	0.4997
38492367	Phytomedicine : international journal of phytotherapy and phytopharmacology	2024	Multiomic study of the protective mechanism of Persicaria capitata (Buch.-Ham. ex D.Don) H.Gross against streptozotocin-induced diabetic nephropathy in Guizhou miniature pigs.		novel_circ_00240 45 	ssc_circ_ULK4	ULK4	diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	dysregulated	RNA-seq	"novel_circ_0024045 was identified by RNA sequencing and bioinformatic joint analysis as an important circRNA node in the protective mechanism of P. capitata against DN. It is linked to the ULK4 source gene and coexpressed lncRNAs, but no qPCR validation specific to this circRNA was reported."	0.31
38492367	Phytomedicine : international journal of phytotherapy and phytopharmacology	2024	Multiomic study of the protective mechanism of Persicaria capitata (Buch.-Ham. ex D.Don) H.Gross against streptozotocin-induced diabetic nephropathy in Guizhou miniature pigs.		novel_circ_0032532 		LOC100625207	diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	dysregulated	RNA-seq	"novel_circ_0032532 was identified by RNA sequencing and bioinformatic joint analysis as an important circRNA node in the P. capitata protective mechanism against DN. It is linked to the LOC100625207 source gene and coexpressed lncRNAs, but the paper did not report qPCR validation specific to this circRNA."	0.31
38492624	Cellular signalling	2024	Circ_0007534 promotes cholangiocarcinoma stemness and resistance to anoikis through DDX3X-mediated positive feedback regulation of parental gene DDX42.	hsa_circ_0007534	circ_0007534	hsa_circ_DDX42	DDX42	cholangiocarcinoma 	MONDO:0019087	cholangiocarcinoma	up-regulated	RT-qPCR	"circ_0007534 is up-regulated in cholangiocarcinoma tissues and cell lines and is associated with lymph node invasion, advanced TNM stage, and poor prognosis. Functionally, it promotes proliferation, migration, invasion, stemness, anoikis resistance, tumor growth, and metastasis. Mechanistically, cytoplasmic circ_0007534 binds the RNA-binding protein DDX3X to stabilize DDX42 mRNA, forming a circ_0007534-DDX3X-DDX42 positive feedback loop that drives CCA progression."	0.8717
38493716	Phytomedicine : international journal of phytotherapy and phytopharmacology	2024	Kaempferol inhibits colorectal cancer metastasis through circ_0000345 mediated JMJD2C/beta-catenin signalling pathway.	hsa_circ_0000345	circ_0000345 			colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; Microarray	"In this study, circ_0000345 is an up-regulated pro-metastatic circRNA in metastatic colorectal cancer. It sponges miR-205-5p to increase JMJD2C expression and activate beta-catenin signaling, thereby promoting CRC migration and metastasis. Kaempferol inhibits CRC metastasis by binding HNRNPK/HNRNPL and reducing circ_0000345-mediated JMJD2C/beta-catenin signaling."	0.7375
38494582	Journal of the Egyptian National Cancer Institute	2024	CircMCTP2 enhances the progression of bladder cancer by regulating the miR-99a-5p/FZD8 axis.		circMCTP2 	hsa_circ_MCTP2	MCTP2	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"CircMCTP2 is up-regulated in bladder cancer tissues and cell lines, and higher expression is linked to metastasis and poorer overall survival. Functionally, circMCTP2 promotes proliferation, migration, invasion, metastasis and xenograft tumor growth while suppressing apoptosis. Mechanistically, it acts through the miR-99a-5p/FZD8/Wnt-b-catenin axis and may represent a therapeutic target or biomarker for bladder cancer."	0.7126
38513057	DNA and cell biology	2024	Circ-EIF3I Promotes Hepatocellular Carcinoma Progression Through Modulating miR-361-3p/DUSP2 Axis.	hsa_circ_0011385	circ-EIF3I	hsa_circ_EIF3I	EIF3I	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ-EIF3I (hsa_circ_0011385) is up-regulated in HCC cell lines and functions as an oncogenic circRNA. Silencing circ-EIF3I suppresses HCC proliferation, migration, xenograft tumor growth and pulmonary metastasis. Mechanistically, circ-EIF3I promotes DUSP2 expression by sponging miR-361-3p, forming a circ-EIF3I/miR-361-3p/DUSP2 regulatory axis."	0.7416
38513058	DNA and cell biology	2024	EIF4A3-Bound hsa_circ_0006847 Exerts a Tumor-Suppressive Role in Gastric Cancer.	hsa_circ_0006847	circASPHD1	hsa_circ_ASPHD1	ASPHD1	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"hsa_circ_0006847/circASPHD1 is downregulated in gastric cancer tissues, plasma and cell lines and acts as a tumor suppressor. Its overexpression inhibits proliferation, migration, invasion, cell cycle progression and xenograft growth while promoting apoptosis, mainly through nuclear binding/recruitment of EIF4A3 and promotion of EIF4A3-SYNPO2 interaction. Low expression is associated with poorer prognosis, supporting its potential as a therapeutic target."	0.8689
38518727	Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy	2024	TRIM29 facilitates gemcitabine resistance via MEK/ERK pathway and is modulated by circRPS29/miR-770-5p axis in PDAC.	hsa_circ_0031773	circRPS29	hsa_circ_RPS29	RPS29	Pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR	"circRPS29 is upregulated in PDAC tissues and high expression is associated with poor survival. Mechanistically, circRPS29 sponges miR-770-5p to increase TRIM29 expression, thereby activating the MEK/ERK pathway and promoting gemcitabine resistance, proliferation, invasion, cell-cycle progression, and xenograft tumor growth."	0.8489
38526683	Molecular biotechnology	2025	Hypoxia-Challenged Pancreatic Adenocarcinoma Cell-Derived Exosomal circR3HCC1L Drives Tumor Growth Via Upregulating PKM2 Through Sequestering miR-873-5p.	hsa_circ_0007678	circR3HCC1L	hsa_circ_R3HCC1L	R3HCC1L	Pancreatic adenocarcinoma 	MONDO:0006047	pancreatic adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circR3HCC1L is up-regulated in PAAD tissues, PAAD cells, and hypoxia-challenged PAAD cell-derived exosomes. It promotes PAAD proliferation, migration, invasion, glycolysis, malignant transformation, and xenograft tumor growth by sponging miR-873-5p and upregulating PKM2, and exosomal circR3HCC1L can be transmitted to recipient PAAD cells under hypoxic conditions."	0.8568
38527707	Transplant immunology	2024	Circular RNA circEfnb2 promotes cell injury after cerebral infarction by sponging miR-202-5p and regulating TRAF3 expression.	mmu_circ_0015034	circEfnb2 	mmu_circ_Efnb2	Efnb2	cerebral infarction 	MONDO:0002679	cerebral infarction	up-regulated	RT-qPCR	"In this study, mouse circEfnb2 was up-regulated in OGD/R-treated HT22 neuronal cells and MCAO mouse brain tissues. circEfnb2 promoted neuronal injury by sponging miR-202-5p and increasing TRAF3 expression, thereby enhancing oxidative stress, inflammation, and apoptosis. Knockdown of circEfnb2 alleviated OGD/R-induced neuronal damage in vitro and cerebral ischemia/reperfusion injury in vivo."	0.7394
38528305	Molecular neurobiology	2024	Circ-Bptf Ameliorates Learning and Memory Impairments via the miR-138-5p/p62 Axis in APP/PS1 Mice.	mmu_circ_0002728	circ-Bptf	mmu_circ_Bptf	Bptf	Alzheimer's disease 	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR; ISH	circ-Bptf is a Bptf-derived mouse circRNA that is downregulated in an age-dependent manner in the hippocampus of APP/PS1 mice. Its overexpression improves learning and memory deficits and synaptic abnormalities by sponging miR-138-5p and increasing p62 expression.	0.717
38528705	Journal of biochemical and molecular toxicology	2024	Exosomal circ_0000735 contributes to non-small lung cancer malignant progression.	hsa_circ_0000735	circ_0000735	hsa_circ_P2RX1	P2RX1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0000735 is upregulated in NSCLC tissues, cells, and serum exosomes and acts as an oncogenic circRNA. It promotes NSCLC proliferation, migration, invasion, EMT, metastasis, and tumorigenesis by sponging miR-345-5p to regulate ADAM19, while exosomal circ_0000735 supports intercellular communication and may serve as a diagnostic biomarker."	0.7855
38533528	Journal of biochemical and molecular toxicology	2024	Silencing of circ_0088036 inhibits growth and invasion of lung adenocarcinoma through miR-203/SP1 axis.	hsa_circ_0088036	circ_0088036			lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"Circ_0088036 is up-regulated in LUAD tissues and cell lines, and high expression is associated with poor prognosis and adverse clinicopathological features. Functionally, circ_0088036 promotes LUAD cell growth, invasion, EMT, and xenograft tumor growth while suppressing apoptosis. Mechanistically, it acts through a circ_0088036/miR-203/SP1 ceRNA axis."	0.7976
38536049	American journal of hypertension	2024	Circ_0104652 Promotes the Proliferation and Migration of ox-LDL-Stimulated Vascular Smooth Muscle Cells via Stabilizing ADAMTS7 and HMGB1.	hsa_circ_0104652	circ_0104652	hsa_circ_ADAMTS7	ADAMTS7	Atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"circ_0104652 is up-regulated in ox-LDL-induced VSMCs, an in vitro atherosclerosis model. It promotes VSMC proliferation and migration while suppressing apoptosis by recruiting the RBP EIF4A3 to stabilize ADAMTS7 and HMGB1 mRNAs, thereby contributing to AS-related cellular dysfunction."	0.7918
38536538	Journal of molecular neuroscience : MN	2024	Competing Endogenous RNAs Crosstalk in Hippocampus: A Potential Mechanism for Neuronal Developing Defects in Down Syndrome.	hsa_circ_0061697				Down syndrome 	MONDO:0008608	Down syndrome	dysregulated	RNA-seq	"hsa_circ_0061697 was identified from RNA-seq-based ceRNA network analysis of DS fetal hippocampus. It may sponge hsa-miR-548b-5p, miR-730-5p and hsa-miR-548i to regulate hub mRNAs including B3GALT5, HELLS, THBS2, GART and CLTCL1, potentially contributing to PI3K/Akt/mTOR and Wnt pathway activation in DS-related neuronal developmental defects."	0.1768
38536538	Journal of molecular neuroscience : MN	2024	Competing Endogenous RNAs Crosstalk in Hippocampus: A Potential Mechanism for Neuronal Developing Defects in Down Syndrome.		hsa_circ_001917			Down syndrome 	MONDO:0008608	Down syndrome	up-regulated	RNA-seq	Hsa_circ_001917 was identified by total RNA-seq as the most upregulated circRNA in DS fetal hippocampal samples. The study did not provide further mechanistic or functional validation for this circRNA.	0.1155
38536538	Journal of molecular neuroscience : MN	2024	Competing Endogenous RNAs Crosstalk in Hippocampus: A Potential Mechanism for Neuronal Developing Defects in Down Syndrome.		novel_circ_006201			Down syndrome 	MONDO:0008608	Down syndrome	down-regulated	RNA-seq	"novel_circ_006201 was identified by total RNA-seq as the most downregulated circRNA in DS fetal hippocampal samples. No downstream ceRNA partners, pathways, or functional validation were reported for this circRNA."	0.1155
38536538	Journal of molecular neuroscience : MN	2024	Competing Endogenous RNAs Crosstalk in Hippocampus: A Potential Mechanism for Neuronal Developing Defects in Down Syndrome.	hsa_circ_0002485				Down syndrome 	MONDO:0008608	Down syndrome	dysregulated	RNA-seq	"hsa_circ_0002485 was included in a RNA-seq-derived ceRNA network in DS fetal hippocampus. It was predicted to share a miR-730-5p binding site in relation to hub target mRNAs B3GALT5, CLTCL1, HELLS and THBS2, but it was not independently validated by RT-qPCR."	0.1768
38536538	Journal of molecular neuroscience : MN	2024	Competing Endogenous RNAs Crosstalk in Hippocampus: A Potential Mechanism for Neuronal Developing Defects in Down Syndrome.		hsa_circ_001101			Down syndrome 	MONDO:0008608	Down syndrome	dysregulated	RNA-seq	"hsa_circ_001101 was identified as part of a predicted ceRNA crosstalk module in DS fetal hippocampus. It was predicted to competitively combine with novel_m0126-5p, novel_m0104-5p and novel_m0131-5p, which could target MIS12, but this circRNA-specific interaction was not experimentally validated."	0.1768
38537964	Anticancer research	2024	Hsa_circTCF25 Facilitates Oncogenesis in Gastric Cancer Cells by Modulating miR-149 Expression.	hsa_circ_0041103	hsa_circTCF25 	hsa_circ_TCF25	TCF25	gastric cancer	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"In this study, circTCF25/hsa_circ_0041103 was up-regulated in human gastric cancer tissues and cell lines and high expression predicted shorter overall survival. Functional knockdown experiments indicated that circTCF25 promotes gastric cancer cell proliferation, migration, invasion and CSC marker expression. Mechanistically, the study supports a circTCF25-miR-149 regulatory network with predicted downstream mRNAs and cancer-related pathways such as PI3K-AKT and MAPK."	0.7283
38546290	Environmental toxicology	2024	Circ_0027791 contributes to the growth and immune evasion of hepatocellular carcinoma via the miR-496/programmed cell death ligand 1 axis in an m6A-dependent manner.	hsa_circ_0027791	circ_0027791	hsa_circ_NTN4		hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0027791 is upregulated in HCC tissues and cells, and high expression is associated with poorer overall survival. Functionally, it promotes HCC proliferation, invasion, sphere formation, tumor growth, M2 macrophage polarization, and immune evasion. Mechanistically, METTL3-mediated m6A modification stabilizes circ_0027791, which sponges miR-496 to increase PDL1 expression."	0.8611
38548218	Cancer letters	2024	Circular RNA circTATDN3 promotes the Warburg effect and proliferation in colorectal cancer.	hsa_circ_0016404	circTATDN3 	hsa_circ_TATDN3	TATDN3	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circTATDN3 is up-regulated in colorectal cancer cells and tumor tissues, and high expression is associated with poor postoperative prognosis. It promotes CRC proliferation, tumor growth, and the Warburg effect by scaffolding LDHA and FGFR1 to enhance LDHA phosphorylation and by sponging miR-511-5p to increase LDHA expression. These findings suggest circTATDN3 as a potential therapeutic target and prognostic biomarker in CRC."	0.9018
38554447	International immunopharmacology	2024	"The mmu_circ_003062, hsa_circ_0075663/miR-490-3p/CACNA1H axis mediates apoptosis in renal tubular cells in association with endoplasmic reticulum stress following ischemic acute kidney injury."	mmu_circ_0030602	mmu_circ_003062 			acute kidney injury 	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR; Microarray	"mmu_circ_003062 is induced in mouse kidneys and BUMPT cells after ischemia/reperfusion injury. It promotes renal tubular cell apoptosis and ischemic AKI progression by sponging miR-490-3p, increasing CACNA1H, and activating ER stress-associated GRP78/CHOP signaling; its knockdown alleviates renal injury in mice."	0.6174
38554447	International immunopharmacology	2024	"The mmu_circ_003062, hsa_circ_0075663/miR-490-3p/CACNA1H axis mediates apoptosis in renal tubular cells in association with endoplasmic reticulum stress following ischemic acute kidney injury."	hsa_circ_0075663				acute kidney injury 	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR	hsa_circ_0075663 is increased in HK-2 cells after ischemia/reperfusion and in plasma and urine from patients with CPR-associated AKI. It promotes renal tubular epithelial cell apoptosis through the miR-490-3p/CACNA1H/GRP78/CHOP axis and has potential diagnostic biomarker value for ischemic AKI.	0.6028
38557813	Biochemical genetics	2025	CircRNA (circ)_0007823 Contributes to Triple-Negative Breast Cancer Progression and Cisplatin Resistance via the miR-182-5p/FOXO1 Pathway.	hsa_circ_0007823	circ_0007823 	hsa_circ_USP42	USP42	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	down-regulated	RT-qPCR	"This study identifies circ_0007823/circUSP42 as a suppressive circRNA in DDP-resistant TNBC cells. circ_0007823 overexpression promotes apoptosis, inhibits migration and invasion, and improves cisplatin sensitivity through interaction with miR-182-5p and the miR-182-5p/FOXO1 axis. Its downregulation is linked to adverse TNBC prognosis, suggesting biomarker and therapeutic potential."	0.5223
38561971	Journal of biochemical and molecular toxicology	2024	"Effects of silencing hsa_circ_0015326 on proliferation, migration, invasion, and apoptosis of epithelial ovarian cancer cells."	hsa_circ_0015326		hsa_circ_RABGAP1L	RABGAP1L	epithelial ovarian cancer 	MONDO:0005140	ovarian carcinoma	up-regulated	RT-qPCR	"This study shows that hsa_circ_0015326 is up-regulated in epithelial ovarian cancer cell lines A2780 and SKOV3 compared with healthy ovarian epithelial cells. Functional silencing experiments indicate that hsa_circ_0015326 promotes malignant phenotypes, including proliferation, migration, and invasion, while suppressing apoptosis, suggesting an oncogenic role and potential value as an early diagnostic biomarker."	0.421
38564421	Journal of molecular endocrinology	2024	circ_0134120: a new frontier in understanding postmenopausal osteoporosis pathogenesis.	hsa_circ_0134120	circ_0134120			postmenopausal osteoporosis 	MONDO:0008159	postmenopausal osteoporosis	dysregulated	Microarray	"hsa_circ_0134120 is a dysregulated circRNA identified from GEO postmenopausal OP profiles. The study supports a circ_0134120/miR-590-5p/STAT3 regulatory axis in which circ_0134120 binds miR-590-5p, increases STAT3 expression, and may promote postmenopausal OP by inhibiting osteogenic differentiation of BMSCs."	0.6157
38564421	Journal of molecular endocrinology	2024	circ_0134120: a new frontier in understanding postmenopausal osteoporosis pathogenesis.	hsa_circ_0063731	circ_0063731			postmenopausal osteoporosis 	MONDO:0008159	postmenopausal osteoporosis	dysregulated	Microarray	"hsa_circ_0063731 was identified as a dysregulated circRNA in postmenopausal OP profiles and incorporated into a predicted circRNA-miRNA-mRNA network. Its experimentally tested miRNA binding was weak relative to hsa_circ_0134120, so its role remains mainly bioinformatically supported."	0.4375
38564421	Journal of molecular endocrinology	2024	circ_0134120: a new frontier in understanding postmenopausal osteoporosis pathogenesis.	hsa_circ_0037112	circ_0037112			postmenopausal osteoporosis 	MONDO:0008159	postmenopausal osteoporosis	dysregulated	Microarray	"hsa_circ_0037112 was identified as a dysregulated circRNA in postmenopausal OP and included in the predicted regulatory network. The paper suggests it could sponge has-miR-590-5p and has-miR-566 to affect multiple target genes, although experimental binding evidence was weak compared with hsa_circ_0134120."	0.4375
38564421	Journal of molecular endocrinology	2024	circ_0134120: a new frontier in understanding postmenopausal osteoporosis pathogenesis.	hsa_circ_0093692	circ_0093692			postmenopausal osteoporosis 	MONDO:0008159	postmenopausal osteoporosis	dysregulated	Microarray	"hsa_circ_0093692 was identified as a dysregulated circRNA in postmenopausal OP profiles and incorporated into a predicted circRNA-miRNA-mRNA network. Its role is mainly computationally supported, and its tested miRNA binding was weak compared with hsa_circ_0134120."	0.4375
38565412	Cellular signalling	2024	Hsa_circ_0005320 affects cell proliferation and the cell cycle via the IGF2BP3/CDK2 axis in bladder cancer.	hsa_circ_0005320	hsa_-circ_0005320	hsa_circ_SEPT9	SEPT9	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005320 is upregulated in bladder cancer tissues and is associated with unfavorable clinicopathologic characteristics, including tumor differentiation and invasion depth. Functionally, it promotes BCa cell proliferation, colony formation, cell cycle progression, and in vivo tumor growth. Mechanistically, it binds and upregulates IGF2BP3, which enhances CDK2 mRNA stability, forming a pro-oncogenic hsa_circ_0005320/IGF2BP3/CDK2 axis."	0.8399
38566477	Experimental dermatology	2024	CircROR1 upregulates CCNE1 expression to promote melanoma invasion and metastasis by recruiting KAT2A.	hsa_circ_0000082	CircROR1	hsa_circ_ROR1	ROR1	Melanoma 	MONDO:0005105	melanoma	up-regulated	RT-qPCR; ISH; Microarray	"CircROR1 (hsa_circ_0000082), derived from ROR1, is up-regulated in metastatic melanoma cells and tissues. It promotes melanoma proliferation, invasion and metastasis by recruiting KAT2A to enhance H3K9ac acetylation at the CCNE1 promoter and increase CCNE1 expression. The study suggests CircROR1 may be a therapeutic target and predictor of melanoma invasion/metastasis."	0.867
38569888	The Tohoku journal of experimental medicine	2024	"Serum CircNIPSNAP3A is Associated with Metabolic Disorders, Atherosclerosis and Severity of Coronary Artery Disease in a Chinese Population."	hsa_circ_0001879	CircNIPSNAP3A	hsa_circ_NIPSNAP3A	NIPSNAP3A	metabolic disorders	MONDO:0005066	metabolic disease	up-regulated	RT-qPCR	"This clinical study found that serum circNIPSNAP3A is up-regulated in atherosclerosis and CAD patients and independently associated with CAD. Higher circNIPSNAP3A levels correlate with adverse metabolic risk factors and more severe CAD, suggesting value as a serum biomarker and possible therapeutic target."	0.2995
38569888	The Tohoku journal of experimental medicine	2024	"Serum CircNIPSNAP3A is Associated with Metabolic Disorders, Atherosclerosis and Severity of Coronary Artery Disease in a Chinese Population."	hsa_circ_0000284	CircHIPK3	hsa_circ_HIPK3	HIPK3	metabolic disorders	MONDO:0005066	metabolic disease	dysregulated	RT-qPCR	"This clinical study measured serum circHIPK3 by RT-qPCR and found altered expression across coronary status groups, with higher expression in atherosclerosis than in normal coronary artery or CAD groups. circHIPK3 was negatively correlated with APOAI but was not significantly associated with CAD incidence or severity, indicating limited clinical relevance in this cohort."	0.2995
38569888	The Tohoku journal of experimental medicine	2024	"Serum CircNIPSNAP3A is Associated with Metabolic Disorders, Atherosclerosis and Severity of Coronary Artery Disease in a Chinese Population."	hsa_circ_0001879	CircNIPSNAP3A	hsa_circ_NIPSNAP3A	NIPSNAP3A	atherosclerosis	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"This clinical study found that serum circNIPSNAP3A is up-regulated in atherosclerosis and CAD patients and independently associated with CAD. Higher circNIPSNAP3A levels correlate with adverse metabolic risk factors and more severe CAD, suggesting value as a serum biomarker and possible therapeutic target."	0.2995
38569888	The Tohoku journal of experimental medicine	2024	"Serum CircNIPSNAP3A is Associated with Metabolic Disorders, Atherosclerosis and Severity of Coronary Artery Disease in a Chinese Population."	hsa_circ_0000284	CircHIPK3	hsa_circ_HIPK3	HIPK3	atherosclerosis	MONDO:0005311	atherosclerosis	dysregulated	RT-qPCR	"This clinical study measured serum circHIPK3 by RT-qPCR and found altered expression across coronary status groups, with higher expression in atherosclerosis than in normal coronary artery or CAD groups. circHIPK3 was negatively correlated with APOAI but was not significantly associated with CAD incidence or severity, indicating limited clinical relevance in this cohort."	0.2995
38569888	The Tohoku journal of experimental medicine	2024	"Serum CircNIPSNAP3A is Associated with Metabolic Disorders, Atherosclerosis and Severity of Coronary Artery Disease in a Chinese Population."	hsa_circ_0001879	CircNIPSNAP3A	hsa_circ_NIPSNAP3A	NIPSNAP3A	coronary artery disease 	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR	"This clinical study found that serum circNIPSNAP3A is up-regulated in atherosclerosis and CAD patients and independently associated with CAD. Higher circNIPSNAP3A levels correlate with adverse metabolic risk factors and more severe CAD, suggesting value as a serum biomarker and possible therapeutic target."	0.2995
38569888	The Tohoku journal of experimental medicine	2024	"Serum CircNIPSNAP3A is Associated with Metabolic Disorders, Atherosclerosis and Severity of Coronary Artery Disease in a Chinese Population."	hsa_circ_0000284	CircHIPK3	hsa_circ_HIPK3	HIPK3	coronary artery disease 	MONDO:0005010	coronary artery disorder	dysregulated	RT-qPCR	"This clinical study measured serum circHIPK3 by RT-qPCR and found altered expression across coronary status groups, with higher expression in atherosclerosis than in normal coronary artery or CAD groups. circHIPK3 was negatively correlated with APOAI but was not significantly associated with CAD incidence or severity, indicating limited clinical relevance in this cohort."	0.2995
38570000	International journal of biological macromolecules	2024	Super enhancer-associated circRNA-circLrch3 regulates hypoxia-induced pulmonary arterial smooth muscle cells pyroptosis by formation of R-loop with host gene.		circLrch3 	mmu_circ_Lrch3	Lrch3	pulmonary hypertension 	MONDO:0005149	pulmonary hypertension	up-regulated	RT-qPCR; ISH; RNA-seq	"circLrch3 is a hypoxia-upregulated mouse circRNA derived from Lrch3 that promotes PASMC pyroptosis and pulmonary hypertension progression. Mechanistically, Tbx2/super-enhancer activity increases circLrch3 transcription; circLrch3 binds Tet1 and forms an R-loop with the Lrch3 promoter, elevating Lrch3 expression and activating NLRP3/Caspase-1-related pyroptosis."	0.7986
38572579	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2024	hsa_circ_0007919 promotes pancreatic cancer metastasis by modulating Sp1-mediated THBS1 transcription.	hsa_circ_0007919		hsa_circ_ABR	ABR	pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0007919 is up-regulated in pancreatic cancer tissues and cells and its high expression is associated with lymph node invasion, TNM stage, and poor overall survival. Functionally, it promotes proliferation, migration, invasion, EMT-related marker changes, and metastasis. Mechanistically, the nuclear circRNA recruits Sp1 to the THBS1 promoter to inhibit THBS1 transcription, supporting pancreatic cancer metastatic progression."	0.8655
38575112	Journal of genetics and genomics = Yi chuan xue bao	2024	Functional role of circRNA CHRC through miR-431-5p/KLF15 signaling axis in the progression of heart failure.	mmu_circ_0014834	circRNA CHRC 	mmu_circ_Sorbs2	Sorbs2	heart failure 	MONDO:0005252	heart failure	down-regulated	RT-qPCR; RNA-seq	"circRNA CHRC is down-regulated in TAC-induced heart failure and Ang-II-induced cardiomyocyte hypertrophy models. It acts protectively by sponging miR-431-5p, thereby maintaining Klf15 expression, reducing cardiomyocyte hypertrophy and fibrosis, and delaying heart failure progression."	0.7698
38579562	International immunopharmacology	2024	Integrative analyses of whole-transcriptome sequencing reveals CeRNA regulatory network in pulmonary hypertension treated with FGF21.		circ_Rbm27	mmu_circ_Rbm27	Rbm27	pulmonary hypertension 	MONDO:0005149	pulmonary hypertension	up-regulated	RT-qPCR; RNA-seq	"circ_Rbm27 was upregulated in hypoxic mouse lung tissues and its expression was reversed by FGF21 treatment. It was included among qRT-PCR-validated circRNAs in the core ceRNA network, suggesting potential involvement in FGF21-mediated protection against HPH."	0.3684
38579562	International immunopharmacology	2024	Integrative analyses of whole-transcriptome sequencing reveals CeRNA regulatory network in pulmonary hypertension treated with FGF21.		circ_mtcp1 	mmu_circ_Mctp1	Mctp1	pulmonary hypertension 	MONDO:0005149	pulmonary hypertension	up-regulated	RT-qPCR; RNA-seq	"circ_mctp1 was upregulated in hypoxic mouse lung tissues and reversed by FGF21 treatment. Luciferase reporter assays supported its interaction with miR-449c/miR-449c-5p, indicating that circ_mctp1 may participate in an FGF21-regulated ceRNA network in HPH."	0.5495
38579562	International immunopharmacology	2024	Integrative analyses of whole-transcriptome sequencing reveals CeRNA regulatory network in pulmonary hypertension treated with FGF21.		circ_Gm672	mmu_circ_Gm672	Gm672	pulmonary hypertension 	MONDO:0005149	pulmonary hypertension	down-regulated	RT-qPCR; RNA-seq	"circ_Gm672 was downregulated in hypoxic mouse lung tissues and its expression was reversed by FGF21 treatment. It was included among qRT-PCR-validated circRNAs in the core ceRNA network, suggesting potential involvement in FGF21-mediated protection against HPH."	0.3684
38579562	International immunopharmacology	2024	Integrative analyses of whole-transcriptome sequencing reveals CeRNA regulatory network in pulmonary hypertension treated with FGF21.		circ_Gfra2	mmu_circ_Gfra2	Gfra2	pulmonary hypertension 	MONDO:0005149	pulmonary hypertension	down-regulated	RT-qPCR; RNA-seq	"circ_Gfra2 was downregulated in hypoxic mouse lung tissues and its expression was reversed by FGF21 treatment. It was included among qRT-PCR-validated circRNAs in the core ceRNA network, suggesting potential involvement in FGF21-mediated protection against HPH."	0.3684
38583745	Cellular signalling	2024	CircUGGT2 facilitates progression and cisplatin resistance of bladder cancer through nonhomologous end-joining pathway.	hsa_circ_0008274	circUGGT2	hsa_circ_UGGT2	UGGT2	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"CircUGGT2 is upregulated in bladder cancer tissues and cell lines and its high expression is associated with aggressive clinicopathological features and poor survival. Mechanistically, circUGGT2 binds the KU70/KU80 heterodimer and enhances recruitment of NHEJ repair factors to damaged chromatin, promoting DNA repair, gammaH2AX formation, and cisplatin resistance."	0.8635
38588560	"APMIS : acta pathologica, microbiologica, et immunologica Scandinavica"	2024	The role of hsa_circ_0042260/miR-4782-3p/LAPTM4A axis in gestational diabetes mellitus.	hsa_circ_0042260		hsa_circ_TOM1L2	TOM1L2	gestational diabetes mellitus 	MONDO:0005406	gestational diabetes	up-regulated	RT-qPCR; ISH; Microarray	"This study identifies hsa_circ_0042260 as an up-regulated circRNA in GDM patient plasma and umbilical cord blood exosomes, as well as in HG-stimulated HK-2 cells. Functionally, hsa_circ_0042260 promotes apoptosis and inflammation while reducing cell viability through the hsa_circ_0042260/miR-4782-3p/LAPTM4A regulatory axis. Its high plasma expression suggests potential diagnostic biomarker value for GDM."	0.7968
38600344	Neuromolecular medicine	2024	Circular RNA-GRIN2B Suppresses Neuropathic Pain by Targeting the NF-kappaB/SLICK Pathway.		Rno_circ_011726	rno_circ_GRIN2B	GRIN2B	neuropathic pain 	MONDO:0021667	neuralgia	up-regulated	RT-qPCR	"circGRIN2B is a rat GRIN2B-derived circRNA upregulated in neuropathic pain-related models. It suppresses CCI-induced neuropathic pain by binding NF-kappaB p65, increasing SLICK expression, reducing DRG neuronal hyperexcitability, and lowering inflammatory cytokines. Overexpression relieves mechanical and thermal hyperalgesia, whereas circGRIN2B downregulation worsens neuropathic pain."	0.8386
38602237	Journal of biochemical and molecular toxicology	2024	CircNRD1 elevates THAP domain containing 11 through sequestering microRNA-421 to inhibit gastric cancer growth and tumorigenesis.	hsa_circ_0009076	circNRD1	hsa_circ_NRD1	NRD1	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"CircNRD1 is down-regulated in gastric cancer tissues and cell lines, and low circNRD1 expression is associated with advanced tumor stage and poor prognosis. Functionally, circNRD1 overexpression suppresses GC cell proliferation, migration, invasion, EMT and xenograft tumor growth. Mechanistically, circNRD1 acts as a miR-421 sponge to increase THAP11 expression through a circNRD1/miR-421/THAP11 ceRNA axis."	0.7975
38602529	ACS sensors	2024	Optical Nanobiosensor Based on Surface-Enhanced Raman Spectroscopy and Catalytic Hairpin Assembly for Early-Stage Lung Cancer Detection via Blood Circular RNA.		circSATB2	hsa_circ_SATB2	SATB2	lung cancer 	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"This study developed a SERS-CHA optical biosensor to quantify serum circSATB2 in human blood for early lung cancer detection. circSATB2 was higher in lung cancer patients than healthy controls, decreased after surgery, and helped distinguish stage IA/IB and IA subtypes, supporting its use as a liquid biopsy biomarker for screening and treatment monitoring."	0.4187
38613646	Histochemistry and cell biology	2024	Circ_100549 promotes tumor progression in lung adenocarcinoma through upregulation of BIRC6.	hsa_circ_0004630	Circ_100549 	hsa_circ_DHTKD1	DHTKD1	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"circ_100549 is upregulated in LUAD cells and acts as an oncogenic circRNA. It promotes LUAD proliferation and xenograft tumor growth while inhibiting apoptosis through a ceRNA mechanism involving miR-95-5p, BPTF, and transcriptional upregulation of BIRC6."	0.8412
38615319	Cell reports	2024	Targeting high circDNA2v levels in colorectal cancer induces cellular senescence and elicits an anti-tumor secretome.		circ16 	hsa_circ_DNA2	DNA2	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Northern Blot; RNA-seq	"circDNA2v is a DNA2-derived human circRNA upregulated in colorectal cancer and associated with poor overall survival. Mechanistically, it binds IGF2BP3, protects IGF2BP3 from ubiquitin-mediated degradation, and stabilizes c-Myc mRNA to maintain CRC cell proliferation and prevent senescence. Silencing circDNA2v induces senescence and a JAK-STAT1-dependent SASP enriched for CXCL10 and IL-9, promoting CD8 + T cell recruitment and cytotoxicity."	0.8898
38618264	Reports of biochemistry & molecular biology	2023	"Association of Circulating Circular RNAs (hg38_circ_0008980, and CircDLGAP4) in Diagnosis, Diseases Severity, and Prognosis of Ischemic Stroke."	hsa_circ_0008980	hg38_circ_0008980 			ischemic stroke 	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR	"hg38_circ_0008980 is a circulating human circRNA significantly down-regulated in peripheral blood within 0_24 hours after ischemic stroke. Its lower expression was associated with IS risk and SVD subtype, while its level positively correlated with NIHSS/stroke severity; however, it did not show significant diagnostic or 6-month functional outcome predictive performance."	0.4187
38618264	Reports of biochemistry & molecular biology	2023	"Association of Circulating Circular RNAs (hg38_circ_0008980, and CircDLGAP4) in Diagnosis, Diseases Severity, and Prognosis of Ischemic Stroke."		CircDLGAP4 	hsa_circ_DLGAP4		ischemic stroke 	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR	"CircDLGAP4 is a circulating human circRNA significantly down-regulated in peripheral blood within 0_24 hours after ischemic stroke. Its expression was negatively associated with IS risk and BMI and positively associated with HDL, but it did not significantly predict diagnosis or 6-month adverse functional outcome in this cohort."	0.4187
38619801	Molecular biotechnology	2025	WTAP-mediated N6-methyladenine Modification of circEEF2 Promotes Lung Adenocarcinoma Tumorigenesis by Stabilizing CANT1 in an IGF2BP2-dependent Manner.	hsa_circ_0000872	circEEF2 	hsa_circ_EEF2	EEF2	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circEEF2 is up-regulated in LUAD tissues and cell lines, and high expression is associated with shorter patient survival. Functionally, circEEF2 promotes angiogenesis, stemness, proliferation, migration, invasion and tumor growth while suppressing apoptosis. Mechanistically, WTAP induces m6A modification of circEEF2, and circEEF2 stabilizes CANT1 through interaction with the m6A reader/RBP IGF2BP2."	0.8658
38621321	Environment international	2024	EIF4A3 modulated circ_000999 promotes epithelial-mesenchymal transition in cadmium-induced malignant transformation through the miR-205-5p/ZEB1 axis.		circ_000999	hsa_circ_AGTPBP1	AGTPBP1	lung cancer 	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; RNA-seq	"circ_000999 is up-regulated during cadmium-induced malignant transformation and in human LC tissues. EIF4A3 promotes circ_000999 expression via the parental gene AGTPBP1, and cytoplasmic circ_000999 promotes EMT by sponging miR-205-5p and increasing ZEB1 expression. The study suggests circ_000999 as a potential diagnostic marker and therapeutic target for LC related to EMT."	0.8356
38621457	Cancer letters	2024	circRNAs as prognostic markers in pediatric acute myeloid leukemia.		circFLT3	hsa_circ_FLT3	FLT3	pediatric acute myeloid leukemia 	MONDO:0004996	childhood acute myeloid leukemia	unknown	RNA-seq	circFLT3 was identified from RNA-seq data as a prognostic circRNA associated with event-free survival in pediatric AML. Its prognostic association was reported to be independent of the corresponding linear FLT3 transcript.	0.348
38621457	Cancer letters	2024	circRNAs as prognostic markers in pediatric acute myeloid leukemia.		circFOXP1	hsa_circ_FOXP1	FOXP1	KMT2A rearranged AML 	MONDO:0850156	B-lymphoblastic leukemia/lymphoma MLL rearranged	unknown	RNA-seq	"circFOXP1 was identified as a subgroup-specific prognostic circRNA in KMT2A rearranged AMLs. Its higher expression correlated with event-free survival, but the study did not elucidate its biological mechanism."	0.348
38621457	Cancer letters	2024	circRNAs as prognostic markers in pediatric acute myeloid leukemia.		circRABEP1	hsa_circ_RABEP1	RABEP1	KMT2A rearranged AML 	MONDO:0850156	B-lymphoblastic leukemia/lymphoma MLL rearranged	unknown	RNA-seq	"circRABEP1 was identified as a prognostic circRNA in the KMT2A rearranged AML subgroup. Its higher expression correlated with overall survival, but no detailed mechanism was tested."	0.348
38621457	Cancer letters	2024	circRNAs as prognostic markers in pediatric acute myeloid leukemia.		circWHSC1	hsa_circ_WHSC1	WHSC1	pediatric acute myeloid leukemia 	MONDO:0004996	childhood acute myeloid leukemia	unknown	RNA-seq	"circWHSC1, derived from WHSC1 exons 2 to 7, was identified as an EFS-associated prognostic circRNA in pediatric AML. Higher transcription was linked to cell-cycle dysregulation and mTORC1-related activity, and the circRNA was predicted to have peptide-coding potential."	0.348
38621457	Cancer letters	2024	circRNAs as prognostic markers in pediatric acute myeloid leukemia.		circKAT6A	hsa_circ_KAT6A	KAT6A	pediatric acute myeloid leukemia 	MONDO:0004996	childhood acute myeloid leukemia	unknown	RNA-seq	"circKAT6A, derived from KAT6A exons 2 to 3, was identified as a prognostic circRNA associated with both EFS and OS. Higher transcription was linked to mTORC1 signaling, TNFalpha signaling and inflammation, and the circRNA was predicted to have peptide-coding potential."	0.348
38621457	Cancer letters	2024	circRNAs as prognostic markers in pediatric acute myeloid leukemia.		circNBAS	hsa_circ_NBAS	NBAS	pediatric acute myeloid leukemia 	MONDO:0004996	childhood acute myeloid leukemia	unknown	RNA-seq	"circNBAS, derived from NBAS exons 10 to 12, was highly expressed in a subset of pediatric AMLs and significantly associated with both EFS and OS. Elevated circNBAS was linked to inferior outcome, apoptosis-related gene activity, KRAS signaling, and predicted peptide-coding potential."	0.348
38621457	Cancer letters	2024	circRNAs as prognostic markers in pediatric acute myeloid leukemia.		circNFIX	hsa_circ_NFIX	NFIX	pediatric acute myeloid leukemia 	MONDO:0004996	childhood acute myeloid leukemia	unknown	RNA-seq	circNFIX was identified in the study as a prognostic circRNA whose higher expression was associated with inferior EFS and OS in AML. The article connected this observation to prior functional reports that circNFIX may promote proliferation and inhibit apoptosis.	0.348
38621457	Cancer letters	2024	circRNAs as prognostic markers in pediatric acute myeloid leukemia.		circDDX6	hsa_circ_DDX6	DDX6	pediatric acute myeloid leukemia 	MONDO:0004996	childhood acute myeloid leukemia	unknown	RNA-seq	circDDX6 was reported as one of the newly identified circRNAs significantly associated with AML prognosis in this RNA-seq-based pediatric AML analysis. No specific mechanism or direction of prognostic effect was provided in the main text.	0.348
38621457	Cancer letters	2024	circRNAs as prognostic markers in pediatric acute myeloid leukemia.		circTRIM24	hsa_circ_TRIM24	TRIM24	pediatric acute myeloid leukemia 	MONDO:0004996	childhood acute myeloid leukemia	unknown	RNA-seq	circTRIM24 was reported as one of the newly identified circRNAs significantly associated with AML prognosis in pediatric AML. The article did not provide a specific mechanism or clear survival direction for this circRNA in the main text.	0.348
38622909	Oral diseases	2024	Knockdown of circXPO1 inhibits the development of oral squamous cell carcinoma cells.	hsa_circ_0005050	circXPO1	hsa_circ_XPO1		oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circXPO1 is an up-regulated, cytoplasmic circRNA in OSCC tissues and cell lines. Functionally, circXPO1 promotes OSCC proliferation, migration, invasion, glycolysis and xenograft tumor growth while suppressing apoptosis. Mechanistically, circXPO1 sponges miR-524-5p to regulate CCND1 expression, suggesting therapeutic relevance for OSCC."	0.8174
38626533	Cancer genetics	2024	CircMYBL1 suppressed acquired resistance to osimertinib in non-small-cell lung cancer.	hsa_circ_0136924	circMYBL1 	hsa_circ_MYBL1	MYBL1	Non-Small-Cell Lung Cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	"circMYBL1/hsa_circ_0136924 is downregulated in osimertinib-resistant NSCLC cell lines and in plasma from osimertinib-resistant NSCLC patients. Knockdown of circMYBL1 reduces osimertinib sensitivity and increases NSCLC cell survival, migration, and invasion, suggesting a suppressive role in acquired osimertinib resistance. The proposed mechanism is a potential cytoplasmic circMYBL1-miRNA-mRNA ceRNA network involving predicted miRNAs and target mRNAs."	0.7514
38626533	Cancer genetics	2024	CircMYBL1 suppressed acquired resistance to osimertinib in non-small-cell lung cancer.	hsa_circ_0009061				Non-Small-Cell Lung Cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0009061 was identified by RNA-Seq and validated by qRT-PCR as significantly downregulated in osimertinib-resistant NSCLC cell lines. The paper did not report functional or mechanistic assays specifically for this circRNA.	0.1904
38626533	Cancer genetics	2024	CircMYBL1 suppressed acquired resistance to osimertinib in non-small-cell lung cancer.	hsa_circ_0004664				Non-Small-Cell Lung Cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0004664 was identified by RNA-Seq and validated by qRT-PCR as significantly downregulated in osimertinib-resistant NSCLC cell lines. The paper did not report functional or mechanistic assays specifically for this circRNA.	0.1904
38626533	Cancer genetics	2024	CircMYBL1 suppressed acquired resistance to osimertinib in non-small-cell lung cancer.	hsa_circ_0000051				Non-Small-Cell Lung Cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0000051 was identified by RNA-Seq and validated by qRT-PCR as significantly downregulated in osimertinib-resistant NSCLC cell lines. The paper did not report functional or mechanistic assays specifically for this circRNA.	0.1904
38631652	Gene	2024	Construction of ceRNA network mediated by circRNAs screening from microarray and identification of novel biomarkers for myasthenia gravis.	hsa_circ_0004183		hsa_circ_FRMD4	FRMD4	myasthenia gravis 	MONDO:0009688	myasthenia gravis	up-regulated	RT-qPCR; Microarray	hsa_circ_0004183/circFRMD4 is up-regulated in PBMCs from AchR-positive MG patients and shows strong diagnostic potential. The study experimentally supports that circFRMD4 directly binds miR-145-5p and promotes Jurkat T-cell proliferation through a circFRMD4/miR-145-5p axis.	0.7941
38631652	Gene	2024	Construction of ceRNA network mediated by circRNAs screening from microarray and identification of novel biomarkers for myasthenia gravis.	hsa_circ_0035381		hsa_circ_PIGB	PIGB	myasthenia gravis 	MONDO:0009688	myasthenia gravis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0035381/circPIGB is up-regulated in PBMCs from MG patients and was validated by RT-qPCR. The study proposes circPIGB as a potential diagnostic biomarker for AchR-positive MG, while its specific miRNA/mRNA mechanism was not experimentally defined."	0.6556
38631652	Gene	2024	Construction of ceRNA network mediated by circRNAs screening from microarray and identification of novel biomarkers for myasthenia gravis.	hsa_circ_0089153		hsa_circ_NUP214	NUP214	myasthenia gravis 	MONDO:0009688	myasthenia gravis	down-regulated	RT-qPCR; Microarray	"hsa_circ_0089153/circNUP214 is down-regulated in PBMCs from MG patients and was validated by RT-qPCR. It was identified as a hub circRNA in the ceRNA network and proposed as a potential diagnostic biomarker for AchR-positive MG, but its specific MG mechanism was not directly validated."	0.6556
38635900	Cancer research	2024	The circMYBL2-Encoded p185 Protein Suppresses Colorectal Cancer Progression by Inhibiting Serine Biosynthesis.	hsa_circ_0006332		hsa_circ_MYBL2	MYBL2	colorectal cancer	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"circMYBL2 is downregulated in colorectal cancer tissues and cell lines and encodes the 185-aa protein p185. p185 acts as a tumor suppressor by competitively binding UCHL3, reducing UCHL3-mediated deubiquitination of PHGDH, promoting PHGDH degradation, and lowering serine and glycine biosynthesis, thereby inhibiting colorectal cancer growth, invasion and metastasis."	0.8547
38642175	Biochemical genetics	2025	Hsa_circ_0006260 Mediates Trophoblast Function by Fibronectin Type III Domains Containing Protein 5 via Interacting with miR-770-5p.	hsa_circ_0006260		hsa_circ_SLC41A2	SLC41A2	gestational diabetes mellitus 	MONDO:0005406	gestational diabetes	down-regulated	RT-qPCR	"hsa_circ_0006260 is down-regulated in placentas from GDM patients and in HG-stimulated HTR-8/SVneo trophoblast cells. It primarily localizes to the cytoplasm and functions as a miR-770-5p decoy, thereby upregulating FNDC5 and protecting trophoblast cells from HG-induced dysfunction, including reduced viability and migration, increased inflammatory cytokine response, and apoptosis. The study proposes hsa_circ_0006260 as a potential therapeutic target for GDM."	0.7977
38642609	Cancer letters	2024	Tumor-associated macrophage-induced circMRCKalpha encodes a peptide to promote glycolysis and progression in hepatocellular carcinoma.	hsa_circ_0003659	circMRCKalpha	hsa_circ_CDC42BPA		hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circMRCKalpha is a TAM-induced circular RNA upregulated in HCC cells exposed to tumor-associated macrophages. It encodes the peptide circMRCKalpha-227aa, which binds USP22 and stabilizes HIF-1alpha through deubiquitination, promoting glycolysis and HCC progression. Clinically, high circMRCKalpha expression is associated with poor survival and increased recurrence."	0.8888
38642609	Cancer letters	2024	Tumor-associated macrophage-induced circMRCKalpha encodes a peptide to promote glycolysis and progression in hepatocellular carcinoma.	hsa_circ_0002457	circATX2	hsa_circ_ATX2		hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circATX2 was one of two candidate circRNAs significantly upregulated in TAM-treated HCC cells after circRNA sequencing and qRT-PCR validation. Unlike circMRCKalpha, elevated circATX2 expression did not correlate with HCC patient survival or recurrence, and the paper did not report additional functional or mechanistic studies for circATX2."	0.6676
38646884	Journal of gastroenterology and hepatology	2024	CircSOD2: Disruption of intestinal mucosal barrier function in ulcerative colitis by regulating the miR-378g/Snail1 axis.	hsa_circ_0004662	CircSOD2	hsa_circ_SOD2	SOD2	ulcerative colitis 	MONDO:0005101	ulcerative colitis	up-regulated	RT-qPCR	"CircSOD2 is up-regulated in ulcerative colitis patients and in LPS-induced Caco2 UC models. It promotes intestinal mucosal barrier injury and inflammation by sponging miR-378g and positively regulating Snail1, while circSOD2 knockdown improves barrier function in vitro and in DSS-induced UC rats. The study suggests circSOD2 may be a therapeutic target for UC."	0.6536
38647743	Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology	2024	Brain-Derived Exosomal CircRNAs in Plasma Serve as Diagnostic Biomarkers for Acute Ischemic Stroke.	hsa_circ_0007290	hsa_circRNA_007290	hsa_circ_FUNDC1	FUNDC1	Acute ischemic stroke 	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0007290 is an up-regulated plasma brain-derived exosomal circRNA in AIS. It was validated by RT-qPCR in a clinical cohort and showed diagnostic potential and positive association with NIHSS and mRS scores.	0.559
38647743	Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology	2024	Brain-Derived Exosomal CircRNAs in Plasma Serve as Diagnostic Biomarkers for Acute Ischemic Stroke.	hsa_circ_0049637	hsa_circRNA_049637	hsa_circ_CALR	CALR	Acute ischemic stroke 	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0049637 is an up-regulated plasma brain-derived exosomal circRNA in AIS. It was validated by RT-qPCR and evaluated by ROC analysis, supporting its potential as an AIS diagnostic and progression-related biomarker."	0.559
38647743	Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology	2024	Brain-Derived Exosomal CircRNAs in Plasma Serve as Diagnostic Biomarkers for Acute Ischemic Stroke.	hsa_circ_0000607	hsa_circRNA_101543	hsa_circ_VPS13C	VPS13C	Acute ischemic stroke 	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0000607 is an up-regulated plasma brain-derived exosomal circRNA in AIS. The study validated its elevation in patients and reported strong diagnostic performance by ROC analysis.	0.559
38647743	Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology	2024	Brain-Derived Exosomal CircRNAs in Plasma Serve as Diagnostic Biomarkers for Acute Ischemic Stroke.	hsa_circ_0004808	hsa_circRNA_100093	hsa_circ_USP48	USP48	Acute ischemic stroke 	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0004808 is an up-regulated plasma brain-derived exosomal circRNA in AIS. It was validated in clinical plasma-derived exosomes and showed diagnostic and disease severity associations.	0.559
38647743	Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology	2024	Brain-Derived Exosomal CircRNAs in Plasma Serve as Diagnostic Biomarkers for Acute Ischemic Stroke.	hsa_circ_0000097	hsa_circRNA_100289	hsa_circ_CDC14A	CDC14A	Acute ischemic stroke 	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0000097 is an up-regulated plasma brain-derived exosomal circRNA in AIS. It was validated as a diagnostic biomarker candidate and its conserved mouse counterpart was further examined in the tMCAO model.	0.559
38647743	Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology	2024	Brain-Derived Exosomal CircRNAs in Plasma Serve as Diagnostic Biomarkers for Acute Ischemic Stroke.	mmu_circ_0010380				ischemic stroke 	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR	"mmu_circ_0010380 is the mouse conserved counterpart of hsa_circ_0000097. In tMCAO model mice, its level in plasma brain-derived exosomes increased over time, supporting relevance to ischemic stroke progression in vivo."	0.2586
38648755	Kidney & blood pressure research	2024	Identification of Plasma hsa_circ_0001230 and hsa_circ_0023879 as Potential Novel Biomarkers for Focal Segmental Glomerulosclerosis and circRNA-miRNA-mRNA Network Analysis.	hsa_circ_0001230		hsa_circ_DDX17	DDX17	Focal segmental glomerulosclerosis 	MONDO:0100313	focal segmental glomerulosclerosis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001230 is up-regulated in plasma from patients with FSGS and shows potential diagnostic value. Mechanistically, it may act as a sponge for hsa-miR-106a-5p and regulate PTEN/BCL2L11-mediated podocyte apoptosis."	0.8111
38648755	Kidney & blood pressure research	2024	Identification of Plasma hsa_circ_0001230 and hsa_circ_0023879 as Potential Novel Biomarkers for Focal Segmental Glomerulosclerosis and circRNA-miRNA-mRNA Network Analysis.	hsa_circ_0023879		hsa_circ_SYTL2	SYTL2	Focal segmental glomerulosclerosis 	MONDO:0100313	focal segmental glomerulosclerosis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0023879 is up-regulated in plasma from patients with FSGS and has potential diagnostic value, with a reported AUC of 0.753. Mechanistically, it may sponge hsa-miR-106a-5p and regulate PTEN/BCL2L11-mediated podocyte apoptosis."	0.8111
38649124	Pharmacological research	2024	CircRNA CDR1as affects functional repair after spinal cord injury and regulates fibrosis through the SMAD pathway.		CDR1as 	mmu_circ_CDR1as	CDR1as	spinal cord injury 	MONDO:0043797	spinal cord injury	down-regulated	RT-qPCR; RNA-seq	"This study identifies mouse CDR1as as a down-regulated circRNA in the lesion epicenter after spinal cord injury and validates its expression by qRT-PCR and junction sequencing. Functionally, inhibiting CDR1as reduces spinal fibrotic scarring, inflammation, apoptosis, glial activation, and Smad2/3 phosphorylation while improving neural repair and locomotor recovery. Mechanistically, CDR1as is proposed to act through the miR-7a-5p/TGF-betaR2 axis to regulate TGF-beta/Smad signaling in spinal fibrosis."	0.7795
38650133	"Cellular and molecular biology (Noisy-le-Grand, France)"	2024	circ_JMJD1C expedites breast cancer progression by regulating miR-182-5p/JMJD1C/SOX4 axis.	hsa_circ_0006743		hsa_circ_JMJD1C		breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_JMJD1C is up-regulated in breast cancer tissues and cells and functions as an oncogenic circRNA. It promotes proliferation, migration, invasion, EMT, tumor growth and metastasis while suppressing apoptosis, mainly through sponging miR-182-5p to increase JMJD1C and epigenetically activate SOX4. High circ_JMJD1C expression is reported to predict poor clinical outcomes, suggesting therapeutic potential for targeting circ_JMJD1C in breast cancer."	0.8459
38653797	Nature biotechnology	2025	Therapeutic application of circular RNA aptamers in a mouse model of psoriasis.		circPOLR2A_Lig 	hsa_circ_POLR2A	POLR2A	psoriasis 	MONDO:0005083	psoriasis	down-regulated	RT-qPCR; Northern Blot	"This study develops POLR2A-derived ds-cRNA aptamers, especially circPOLR2A_J/EPIC, as therapeutic circular RNAs for psoriasis. EPIC binds PKR stably and suppresses PKR activation, thereby reducing downstream eIF2alpha phosphorylation, interferon/dsRNA-sensor inflammatory responses, psoriasis signature gene expression, and epidermal thickening in IMQ-induced psoriatic mice and patient-derived PBMCs."	0.6777
38653946	Digestive diseases and sciences	2024	DEAD-Box Helicase 17 circRNA (circDDX17) Reduces Sorafenib Resistance and Tumorigenesis in Hepatocellular Carcinoma.			hsa_circ_DDX17	DDX17	Hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"circDDX17 is down-regulated in HCC tissues and cell lines. Its overexpression suppresses HCC tumorigenesis, reduces sorafenib resistance, promotes apoptosis, and inhibits EMT, partly through the miR-21-5p/PTEN/PI3K/AKT regulatory axis."	0.7581
38657100	Cancer research	2024	Extracellular Vesicles Containing circMYBL1 Induce CD44 in Adenoid Cystic Carcinoma Cells and Pulmonary Endothelial Cells to Promote Lung Metastasis.	hsa_circ_0005883	circMYBL1 	hsa_circ_MYBL1	MYBL1	Adenoid cystic carcinoma 	MONDO:0004971	adenoid cystic carcinoma	up-regulated	RT-qPCR; Microarray	"circMYBL1 is a MYBL1-derived circRNA upregulated in salivary ACC tissues and plasma sEVs, and high expression is associated with lung metastasis and poor survival. It promotes ACC malignant phenotypes and lung metastasis by binding and stabilizing CEBPB, enhancing CEBPB nuclear translocation and CD44 transcription, and by sEV-mediated transfer that increases CD44-dependent adhesion between ACC cells and pulmonary endothelial cells."	0.8973
38662613	"Shock (Augusta, Ga.)"	2024	CIRCVMA21-RELATED PATHWAY ALLEVIATES LIPOPOLYSACCHARIDE-INDUCED HK-2 CELL INJURY.	hsa_circ_0091702	circVMA21	hsa_circ_VMA21	VMA21	sepsis-induced acute kidney injury 	MONDO:0005229	bacterial infectious disease with sepsis	down-regulated	RT-qPCR	"CircVMA21 is downregulated in serum from sepsis-induced AKI patients and in LPS-induced HK2 cells. Functionally, circVMA21 overexpression alleviates LPS-induced HK2 cell injury by promoting proliferation and inhibiting apoptosis, inflammatory cytokine production, and oxidative stress. Mechanistically, circVMA21 acts through the miR-337-3p/ZEB2 axis."	0.8275
38663164	Leukemia research	2024	Circ_0005615 enhances multiple myeloma progression through interaction with EIF4A3 to regulate MAP3K4 m6A modification mediated by ALKBH5.	hsa_circ_0005615		hsa_circ_NFATC3	NFATC3	multiple myeloma 	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR; Microarray	"circ_0005615 is up-regulated in peripheral blood/plasma of MM patients and MM cell lines. It promotes MM progression by enhancing cell viability, invasion, and xenograft tumor growth while inhibiting apoptosis. Mechanistically, circ_0005615 binds EIF4A3 and regulates an EIF4A3-ALKBH5-MAP3K4 module, increasing MAP3K4 m6A methylation and reducing MAP3K4 expression."	0.8686
38664873	"Shock (Augusta, Ga.)"	2024	"miR-208a-3p regulated by circUQCRC2 suppresses ischemia/reperfusion-induced acute kidney injury by inhibiting CELF2-mediated tubular epithelial cell apoptosis, inflammation and ferroptosis."	hsa_circ_0105188	circular RNA ubiquinol-cytochrome c reductase core protein 2 	hsa_circ_UQCRC2	UQCRC2	acute kidney injury 	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR	"circUQCRC2 is up-regulated in H/R-stimulated HK-2 cells and I/R-injured mouse kidneys. It promotes AKI-related tubular epithelial cell injury by negatively regulating miR-208a-3p and increasing CELF2-mediated apoptosis, inflammation, and ferroptosis; circUQCRC2 knockdown protects H/R-injured HK-2 cells."	0.6435
38664873	"Shock (Augusta, Ga.)"	2024	"miR-208a-3p regulated by circUQCRC2 suppresses ischemia/reperfusion-induced acute kidney injury by inhibiting CELF2-mediated tubular epithelial cell apoptosis, inflammation and ferroptosis."	mmu_circ_0013825	circular RNA ubiquinol-cytochrome c reductase core protein 2 	mmu_circ_UQCRC2	UQCRC2	acute kidney injury 	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR	"circUQCRC2 is up-regulated in H/R-stimulated HK-2 cells and I/R-injured mouse kidneys. It promotes AKI-related tubular epithelial cell injury by negatively regulating miR-208a-3p and increasing CELF2-mediated apoptosis, inflammation, and ferroptosis; circUQCRC2 knockdown protects H/R-injured HK-2 cells."	0.6435
38665011	Head & neck	2024	The novel circ_0004674/miR-139-5p/ZBTB2 regulatory cascade inhibits the development of oral squamous cell carcinoma.	hsa_circ_0004674	circ_0004674 	hsa_circ_ADAM22	ADAM22	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"In OSCC, circ_0004674 is up-regulated in tumor tissues and OSCC cell lines and correlates with advanced clinical stage and lymph node metastasis. Functionally, circ_0004674 promotes malignant phenotypes including proliferation, angiogenesis/tube formation and in vivo tumor growth while suppressing apoptosis. Mechanistically, it acts as a cytoplasmic sponge for miR-139-5p to enhance ZBTB2 expression through the circ_0004674/miR-139-5p/ZBTB2 regulatory cascade."	0.8174
38669868	"Pathology, research and practice"	2024	Hsa_circ_0087862 contributes to the progression of colorectal cancer through regulating miR-512-3p/HK2 axis.	hsa_circ_0087862	circ_0087862 	hsa_circ_RAD23B	RAD23B	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"Hsa_circ_0087862 is up-regulated in colorectal cancer tissues and cell lines and functions as a tumor-promoting circRNA. Its knockdown suppresses CRC cell proliferation, migration, invasion, glycolysis and xenograft tumor growth while promoting apoptosis. Mechanistically, circ_0087862 sponges miR-512-3p to up-regulate HK2 expression."	0.8256
38670193	International journal of biological macromolecules	2024	The hsa_circ_0082152 maintains NF-kappaB mRNA stability by binding to MTDH to promote anti-tuberculosis drug-induced liver injury.	hsa_circ_0082152		hsa_circ_SND1	snd1	Anti-tuberculosis drug-induced liver injury 	MONDO:0005359	drug-induced liver injury	up-regulated	RT-qPCR	"hsa_circ_0082152 is upregulated in serum from ADLI patients and in HL-7702-ADLI cells. It promotes inflammatory liver injury by binding MTDH and maintaining NF-kappaB mRNA stability, thereby increasing NF-kappaB signaling and downstream IL-1beta and TNF-alpha expression. Knockdown of hsa_circ_0082152 or MTDH reduces inflammatory injury, supporting the hsa_circ_0082152-MTDH-NF-kappaB axis as a mechanism in ADLI progression."	0.7968
38677350	Gene	2024	The circAno6/miR-296-3p/TLR4 signaling axis mediates the inflammatory response to induce the activation of hepatic stellate cells.	Mmu_circ_0000644	circAno6 	mmu_circ_Ano6	Ano6	liver fibrosis 	MONDO:0100430	fibrotic liver disease	up-regulated	RT-qPCR	"This study identifies circAno6 as an up-regulated circRNA in activated HSCs related to liver fibrosis. circAno6 promotes HSC proliferation, activation and inflammatory responses, likely by acting as a cytoplasmic ceRNA that binds miR-296-3p and relieves repression of TLR4. The authors suggest that targeting circAno6 may be a therapeutic strategy for liver fibrosis."	0.6174
38677725	Anticancer research	2024	Effect of MYC and PARP Inhibitors in Ovarian Cancer Using an In Vitro Model.	hsa_circ_0001821	circular PVT1 	hsa_circ_PVT1	PVT1	ovarian cancer 	MONDO:0008170	ovarian cancer	unknown	RT-qPCR	"This study examined circPVT1 in an ovarian cancer in vitro model and found that rucaparib, a PARP inhibitor, and 10058F4, a MYC inhibitor, significantly reduced circPVT1 expression. The data suggest that down-regulation of circular PVT1 may be part of the anti-tumor effects of PARP and MYC inhibition, although the exact downstream mechanism was not defined."	0.1155
38678605	"Cellular and molecular biology (Noisy-le-Grand, France)"	2024	"Effect of circFOXM1/miR-218-5p on the proliferation, apoptosis and migration of glioma cells."		circFOXM1	hsa_circ_FOXM1	FOXM1	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"This study found that circFOXM1 is upregulated in glioma tissues and promotes malignant glioma cell behaviors. Mechanistically, circFOXM1 targets and negatively regulates miR-218-5p, and circFOXM1 silencing suppresses proliferation, colony formation and migration while promoting apoptosis, with associated changes in E-cadherin and N-cadherin. The authors suggest circFOXM1 may be a potential molecular therapeutic target for glioma."	0.6278
38678610	"Cellular and molecular biology (Noisy-le-Grand, France)"	2024	Biological functions of Circular RNA_LARP4/ Upstream frameshift 1 in development of gastric cancer.		Circular RNA_LARP4 	hsa_circ_LARP4	LARP4	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"Circular RNA_LARP4 is down-regulated in gastric cancer tissues and cell lines. Its overexpression suppresses GC cell proliferation, colony formation, cell cycle progression, migration and invasion, likely through upregulation of UPF1. The study suggests Circular RNA_LARP4 may function as a tumor suppressor and potential clinical indicator in GC."	0.5758
38678850	"Pathology, research and practice"	2024	Circular RNA hsa_circ_0094976 modulates GPR155 to inhibit gastric adenocarcinoma malignant characteristics by targeting miR-223-3p.	hsa_circ_0094976	circ_0094976	hsa_circ_ALG9	ALG9	gastric adenocarcinoma 	MONDO:0005036	gastric adenocarcinoma	down-regulated	RT-qPCR	"This study identifies hsa_circ_0094976/circ_0094976 as a down-regulated tumor-suppressive circRNA in gastric adenocarcinoma. Circ_0094976 is mainly cytoplasmic and suppresses GA proliferation, migration, invasion, EMT-related changes, and xenograft tumor growth by sponging miR-223-3p and up-regulating GPR155. Clinically, higher circ_0094976 expression is associated with smaller tumor size, lower TNM stage, and less lymph node metastasis, suggesting potential diagnostic and therapeutic value."	0.8571
38678936	Environment international	2024	Low-level PM2.5 induces the occurrence of early pulmonary injury by regulating circ_0092363.	hsa_circ_0092363	circ_0092363	hsa_circ_DDX11	DDX11	early pulmonary injury 	MONDO:0015796	acute lung injury	dysregulated	RT-qPCR	"In low-level PM2.5 exposure, circ_0092363 is redistributed from intracellular spaces to extracellular exosomes, resulting in reduced intracellular circ_0092363. This weakens miR-31-5p sponging, suppresses ROCK1 and tight junction proteins ZO-1 and Claudin-1, increases epithelial permeability, and contributes to early pulmonary injury. The study proposes circ_0092363 as a potential diagnostic biomarker for PM2.5-induced early pulmonary injury."	0.6722
38679361	Molecular and cellular endocrinology	2024	CircZNF609 inhibits miR-150-5p to promote high glucose-induced damage to retinal microvascular endothelial cells.		CircZNF609 	hsa_circ_ZNF609	ZNF609	diabetic retinopathy 	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR; Microarray	"CircZNF609 is upregulated in peripheral blood from diabetic retinopathy patients and in high glucose-stimulated hRMECs. It aggravates high glucose-induced endothelial cell injury by sponging and suppressing miR-150-5p, leading to reduced viability and increased apoptosis, tube formation, oxidative stress, and VEGFA/GLUT1 protein expression. The CircZNF609/miR-150-5p axis is proposed as a potential therapeutic target for diabetic retinopathy."	0.6956
38682191	Frontiers in bioscience (Landmark edition)	2024	Exosomal CircRNAs in Circulation Serve as Diagnostic Biomarkers for Acute Myocardial Infarction.	hsa_circ_0001535				acute myocardial infarction 	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001535 was identified by high-throughput sequencing as an up-regulated exosomal circRNA and validated by RT-PCR in plasma exosomes from AMI patients. Its ROC AUC of 0.685 suggests potential diagnostic relevance for AMI, although it was not selected for larger-cohort validation."	0.5047
38682191	Frontiers in bioscience (Landmark edition)	2024	Exosomal CircRNAs in Circulation Serve as Diagnostic Biomarkers for Acute Myocardial Infarction.	hsa_circ_0000972				acute myocardial infarction 	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000972 was identified by high-throughput sequencing as an up-regulated exosomal circRNA and validated by RT-PCR in plasma exosomes from AMI patients. Its ROC AUC of 0.683 indicates potential diagnostic relevance for AMI, although no mechanistic function was tested."	0.5047
38682191	Frontiers in bioscience (Landmark edition)	2024	Exosomal CircRNAs in Circulation Serve as Diagnostic Biomarkers for Acute Myocardial Infarction.	hsa_circ_0001558				acute myocardial infarction 	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001558 was identified as an up-regulated plasma exosomal circRNA in AMI and validated by RT-PCR in both an initial and a larger validation cohort. It showed the strongest diagnostic performance among the validated circRNAs and may serve as a diagnostic biomarker for AMI, NSTEMI, and STEMI."	0.5047
38684479	"Cell cycle (Georgetown, Tex.)"	2024	Hsa_circ_0079875 functions as a competitive endogenous RNA to promote hepatocellular carcinoma progression.	hsa_circ_0079875	hsa_-circ_0079875 	hsa_circ_ANLN	ANLN	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"hsa_circ_0079875 is an ANLN-derived circRNA up-regulated in HCC tissues and mainly localized in the cytoplasm. It promotes HCC progression by enhancing proliferation, migration, invasion, S-phase cell-cycle progression, and tumor growth while inhibiting apoptosis, likely through a ceRNA mechanism involving miR-519d-5p and NRAS. High hsa_circ_0079875 expression is associated with aggressive clinicopathological features and poor survival, suggesting prognostic and therapeutic potential."	0.8585
38685156	Environment international	2024	Mechanism of circRNA_SMG6 mediating lung macrophage ECM degradation via miR-570-3p in microplastics-induced emphysema.			rno_circ_SMG6		microplastics-induced emphysema 	MONDO:0004849	pulmonary emphysema	down-regulated	RT-qPCR	"circRNA_SMG6 is decreased in PS-MPs-induced emphysema models, including rat lung tissues and PS-MPs-treated THP-1 macrophage-like cells. Functionally, circRNA_SMG6 overexpression attenuates PS-MPs-induced ECM and elastin degradation by sponging miR-570-3p and regulating PTEN, thereby reducing MMP9 and MMP12 expression."	0.6683
38685156	Environment international	2024	Mechanism of circRNA_SMG6 mediating lung macrophage ECM degradation via miR-570-3p in microplastics-induced emphysema.	hsa_circ_0041385		hsa_circ_SMG6	SMG6	microplastics-induced emphysema 	MONDO:0004849	pulmonary emphysema	down-regulated	RT-qPCR	"circRNA_SMG6 is decreased in PS-MPs-induced emphysema models, including rat lung tissues and PS-MPs-treated THP-1 macrophage-like cells. Functionally, circRNA_SMG6 overexpression attenuates PS-MPs-induced ECM and elastin degradation by sponging miR-570-3p and regulating PTEN, thereby reducing MMP9 and MMP12 expression."	0.6683
38685451	Cancer letters	2024	circLIFR-007 reduces liver metastasis via promoting hnRNPA1 nuclear export and YAP phosphorylation in breast cancer.	hsa_circ_0072305	circLIFR-007 	hsa_circ_LIFR	LIFR	breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	"circLIFR-007 is a LIFR-derived circRNA that is down-regulated in breast cancer liver metastases and breast cancer cell lines. It suppresses breast cancer proliferation, migration, invasion, tumor growth, and liver metastasis by binding hnRNPA1, promoting hnRNPA1 nuclear export, increasing YAP phosphorylation, retaining YAP in the cytoplasm, and reducing YAP/TEAD-regulated liver metastasis-associated proteins SREBF1 and SNAI1. The study suggests circLIFR-007 may be a biomarker for evaluating breast cancer recurrence and metastasis risk."	0.8817
38688434	Experimental cell research	2024	Circ_PABPC1 promotes the malignancy of gastric cancer through interacting with ILK to activate NF-kappaB pathway.	hsa_circ_0008496	circ_PABPC1 	hsa_circ_PABPC1	PABPC1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circ_PABPC1/hsa_circ_0008496 is up-regulated in gastric cancer tissues and cell lines, and high expression correlates with poor overall survival. Functionally, it promotes proliferation, migration, invasion and xenograft tumor growth of GC cells. Mechanistically, circ_PABPC1 interacts with ILK protein, protects ILK from degradation, and activates NF-kappaB signaling."	0.8891
38691277	Applied biochemistry and biotechnology	2024	"Circular RNA KIAA0564 Serves as a Competitive Endogenous RNA for MicroRNA-424-5p, Mediating the Expression of Lysine Demethylase 4a, Thereby Facilitating Intervertebral Disc Degeneration."	hsa_circ_0030120	circKIAA0564	hsa_circ_KIAA0564	KIAA0564	intervertebral disc degeneration 	MONDO:0011385	intervertebral disk degenerative disorder	up-regulated	RT-qPCR	"CircKIAA0564/hsa_circ_0030120 is overexpressed in IDD patient discs, IL-1beta-induced NP cells, and needle puncture-induced IDD mouse tissues. It acts as a ceRNA for miR-424-5p to regulate KDM4A and activate the TLR4/NF-kappaB/NLRP3 pathway, thereby promoting inflammation, apoptosis, oxidative stress, ECM degradation, and NP tissue damage; knockdown of CircKIAA0564 is protective."	0.8241
38700824	"Reproductive sciences (Thousand Oaks, Calif.)"	2024	Circ_TMCO3 Inhibits the Progression of Cervical Cancer by Activating FRMD6 Expression by Restraining miR-1291.	hsa_circ_0031027	Circ_TMCO3 	hsa_circ_TMCO3	TMCO3	cervical cancer 	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR; Microarray	"Circ_TMCO3 (hsa_circ_0031027), derived from the TMCO3 gene, is downregulated in cervical cancer tissues and cell lines. Its overexpression suppresses cervical cancer progression by sponging miR-1291 and increasing FRMD6 expression, leading to reduced proliferation, migration, invasion, glycolysis and tumor growth, and increased apoptosis. Higher circ_TMCO3 expression is associated with better overall survival and may serve as a molecular marker for treatment and prognosis."	0.8155
38703475	"Blood cells, molecules & diseases"	2024	Decreasing circ_0014614 promotes the differentiation of bone marrow flineage cells into megakaryocytes in essential thrombocythemia via activiation of miR-138-5p/caspase3 axis.	hsa_circ_0014614	circ_0014614 	hsa_circ_DAP3	DAP3	essential thrombocythemia 	MONDO:0005029	essential thrombocythemia	down-regulated	RT-qPCR; ISH	"circ_0014614 is down-regulated in ET bone marrow and bone marrow lineage cells. It acts as a ceRNA that sponges miR-138-5p to relieve repression of caspase3, thereby inhibiting K562 cell proliferation and megakaryocytic differentiation."	0.6429
38704109	Pharmacological research	2024	Targeting tumorous Circ-E-Cadherinencoded C-E-Cad inhibits the recruitment and function of breast cancer-associated myeloid-derived suppressor cells.		circ-E-cadherin 	hsa_circ_E-cadherin	E-cadherin	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ-E-cadherin is upregulated in human breast cancer and encodes the protein C-E-cad, whose high expression is associated with shorter overall survival. C-E-cad activates EGFR/AKT/STAT3 signaling to induce CXCL8 transcription, promoting PMN-MDSC recruitment and immunosuppression, while also acting on MDSCs to enhance glycolytic reprogramming. Targeting C-E-cad suppresses MDSC-mediated immune evasion and improves anti-PD-1 therapeutic efficacy."	0.7887
38711927	Toxicology research	2024	Hsa_circ_0004214 involved in the epithelial-mesenchymal transition induced by beryllium sulfate through modulating JAK-STAT signaling pathway.	hsa_circ_0004214				chronic beryllium disease 	MONDO:0015274	chronic beryllium disease	up-regulated	RT-qPCR	"hsa_circ_0004214 is up-regulated after BeSO4 exposure and contributes to BeSO4-induced EMT associated with pulmonary fibrosis. The study supports a hsa_circ_0004214/hsa-miR-663b/LIF/JAK-STAT regulatory mechanism, in which hsa_circ_0004214 knockdown suppresses EMT and inhibits JAK-STAT pathway activation."	0.5607
38714291	Cancer letters	2024	circVAPA-rich small extracellular vesicles derived from gastric cancer promote neural invasion by inhibiting SLIT2 expression in neuronal cells.	hsa_circ_0006990	circVAPA 	hsa_circ_VAPA	VAPA	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0006990/circVAPA is enriched in plasma small extracellular vesicles and tumor tissues from NI-positive gastric cancer patients and is associated with poor overall survival. Functionally, GC-derived sEV-circVAPA promotes gastric cancer neural invasion by entering neuronal cells, suppressing SLIT2 transcription through the miR-548p/TGIF2 axis, and inhibiting SLIT2 translation through eIF4G1 binding and disruption of the eIF4F complex."	0.9045
38715837	American journal of translational research	2024	Circ_0072088 promotes breast carcinoma progression via modulating miR-607/RNF2 axis.	hsa_circ_0072088				breast carcinoma 	MONDO:0004989	breast carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0072088 is up-regulated in breast carcinoma tissues and cell lines and high expression is associated with reduced overall survival and advanced TNM stage. Functionally, circ_0072088 promotes BC cell viability, proliferation and cell-cycle progression while inhibiting apoptosis. Mechanistically, it acts as a miR-607 sponge to increase RNF2 expression through a ceRNA axis, suggesting diagnostic and therapeutic potential."	0.8252
38724419	Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]	2024	Exploring the prognostic value of circular RNAs in pancreatic ductal adenocarcinoma using genome-wide expression profiling.	hsa_circ_0004771	circ_00059_NRIP1 	hsa_circ_NRIP1	NRIP1	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RNA-seq	"circNRIP1 was up-regulated in PDAC versus controls and was one of three circRNAs with independent prognostic value. Its high expression was associated with poorer survival, but no molecular mechanism was experimentally investigated."	0.5121
38724419	Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]	2024	Exploring the prognostic value of circular RNAs in pancreatic ductal adenocarcinoma using genome-wide expression profiling.	hsa_circ_0007334	circ_00761_MBOAT2 	hsa_circ_MBOAT2	MBOAT2	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	circMBOAT2 was up-regulated in PDAC and its higher expression was linked to poorer survival. The study validated its increased expression by RT-qPCR and identified it as an independent prognostic marker.	0.5534
38724419	Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]	2024	Exploring the prognostic value of circular RNAs in pancreatic ductal adenocarcinoma using genome-wide expression profiling.	hsa_circ_0002360	circ_00684_RUNX1 	hsa_circ_RUNX1	RUNX1	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circRUNX1 was up-regulated in PDAC and its increased expression was validated by RT-qPCR. Higher expression was associated with poorer prognosis, and multivariate analysis supported its independent prognostic value."	0.5047
38724419	Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]	2024	Exploring the prognostic value of circular RNAs in pancreatic ductal adenocarcinoma using genome-wide expression profiling.	hsa_circ_0001946	ciRS-7 	hsa_circ_CDR1as	CDR1-AS	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	dysregulated	RT-qPCR; ISH; RNA-seq	"ciRS-7 was investigated mainly for spatial expression in PDAC. It was absent in PDAC cancer cells but enriched in tumor stroma and fibrotic/inflamed stromal areas, suggesting value as a stromal activity marker rather than as a cancer-cell marker."	0.5267
38726271	American journal of cancer research	2024	Circular RNA circIL21R promotes cervical cancer cells proliferation and migration by sponging the miR-1205/PTBP1 axis.	hsa_circ_0038728	circIL21R	hsa_circ_IL21R	IL21R	cervical cancer	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"circIL21R is up-regulated in cervical cancer and high expression is associated with shorter survival. It promotes cervical cancer cell proliferation, invasion and tumor growth by acting as a ceRNA for miR-1205 to increase PTBP1 expression, while SFRS1 binds circIL21R to maintain its stability."	0.8766
38726809	Analytical methods : advancing methods and applications	2024	A one-pot CRISPR-RCA strategy for ultrasensitive and specific detection of circRNA.	hsa_circ_0001445	circRNA1445			hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"This study used hsa_circ_0001445 (circRNA1445) as a model potential HCC biomarker to establish and validate the RETA-CRISPR detection platform. circRNA1445 expression was detected at lower levels in the hepatocellular carcinoma cell line HepG2 than in the normal hepatic cell line LO2, with agreement between RETA-CRISPR and RT-qPCR. No disease-related functional mechanism or regulatory axis was experimentally investigated."	0.385
38727863	Molecular biology reports	2024	CircCOX6A1 suppresses osteogenic differentiation and aggravates osteoporosis via miR-512-3p/DYRK2 axis.		circCOX6A1 	hsa_circ_COX6A1	COX6A1	osteoporosis 	MONDO:0005298	osteoporosis	up-regulated	RT-qPCR; Microarray	"circCOX6A1 is upregulated in osteoporosis patient serum and in OVX mice, while its expression decreases during BMSC osteogenic differentiation. Functionally, circCOX6A1 suppresses osteogenic differentiation and promotes OP progression by sponging miR-512-3p to upregulate DYRK2; knockdown of circCOX6A1 promotes mineralization and improves OP-related phenotypes in vivo. The study proposes circCOX6A1 as a potential biomarker and therapeutic target for osteoporosis."	0.8375
38727863	Molecular biology reports	2024	CircCOX6A1 suppresses osteogenic differentiation and aggravates osteoporosis via miR-512-3p/DYRK2 axis.		circCOX6A1 	 mmu_circ_COX6A1	COX6A1	osteoporosis 	MONDO:0005298	osteoporosis	up-regulated	RT-qPCR; Microarray	"circCOX6A1 is upregulated in osteoporosis patient serum and in OVX mice, while its expression decreases during BMSC osteogenic differentiation. Functionally, circCOX6A1 suppresses osteogenic differentiation and promotes OP progression by sponging miR-512-3p to upregulate DYRK2; knockdown of circCOX6A1 promotes mineralization and improves OP-related phenotypes in vivo. The study proposes circCOX6A1 as a potential biomarker and therapeutic target for osteoporosis."	0.8375
38729048	Biosensors & bioelectronics	2024	Simultaneous detection of breast cancer biomarkers circROBO1 and BRCA1 based on a CRISPR-Cas13a/Cas12a system.		circROBO1	hsa_circ_ROBO1	ROBO1	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"This study established a CRISPR-Cas13a/Cas12a fluorescence system for sensitive detection of circROBO1 together with BRCA1 in breast cancer-related samples. circROBO1 was upregulated in breast cancer patients compared with healthy donors and showed diagnostic potential with an ROC AUC of 0.875. Mechanistically, the study reported a ceRNA relationship in which circROBO1 regulates BRCA1 by binding miR-498."	0.459
38729588	Pharmacological research	2024	CircUGGT2 downregulation by METTL14-dependent m6A modification suppresses gastric cancer progression and cisplatin resistance through interaction with miR-186-3p/MAP3K9 axis.	hsa_circ_0030632	circUGGT2	hsa_circ_UGGT2	UGGT2	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; ISH	"circUGGT2 is an upregulated oncogenic circRNA in gastric cancer and cisplatin-resistant GC cells. METTL14-dependent m6A modification reduces circUGGT2 expression, while circUGGT2 promotes tumor growth, invasion, metastasis and DDP resistance by sponging miR-186-3p and upregulating MAP3K9. High circUGGT2 expression is associated with poor overall survival in GC patients."	0.8583
38734849	Molecular genetics and genomics : MGG	2024	Signature and function of plasma exosome-derived circular RNAs in patients with hypertensive intracerebral hemorrhage.	hsa_circ_0049667		hsa_circ_NACC1	NACC1	hypertensive intracerebral hemorrhage 	MONDO:0013792	intracerebral hemorrhage	up-regulated	Microarray	hsa_circ_0049667 is an up-regulated plasma exosomal circRNA in HICH. It was among the top differentially expressed exosomal circRNAs correlated with bleeding volume and GCS score and was analyzed as part of a predicted ceRNA network.	0.348
38734849	Molecular genetics and genomics : MGG	2024	Signature and function of plasma exosome-derived circular RNAs in patients with hypertensive intracerebral hemorrhage.	hsa_circ_0093469		hsa_circ_ZMYND11	ZMYND11	hypertensive intracerebral hemorrhage 	MONDO:0013792	intracerebral hemorrhage	up-regulated	Microarray	hsa_circ_0093469 is an up-regulated plasma exosomal circRNA in HICH. It correlated with bleeding volume and GCS score and was included in predicted ceRNA network analyses.	0.348
38734849	Molecular genetics and genomics : MGG	2024	Signature and function of plasma exosome-derived circular RNAs in patients with hypertensive intracerebral hemorrhage.	hsa_circ_0054843	hsa_circ_00054843	hsa_circ_USP34	USP34	hypertensive intracerebral hemorrhage 	MONDO:0013792	intracerebral hemorrhage	up-regulated	Microarray	"hsa_circ_0054843, also referred to in the discussion as hsa_circ_00054843, is an up-regulated plasma exosomal circRNA in HICH. The paper predicts that it may act through a miR-3610-3p/NEDD4L ceRNA axis and may be relevant to hypertension-related etiology, inflammation, and clinical severity."	0.348
38734849	Molecular genetics and genomics : MGG	2024	Signature and function of plasma exosome-derived circular RNAs in patients with hypertensive intracerebral hemorrhage.	hsa_circ_0137509		hsa_circ_GABBR2	GABBR2	hypertensive intracerebral hemorrhage 	MONDO:0013792	intracerebral hemorrhage	up-regulated	Microarray	hsa_circ_0137509 is an up-regulated plasma exosomal circRNA in HICH. It was correlated with bleeding volume and GCS score and included in predicted circRNA-miRNA-mRNA network analyses.	0.348
38734849	Molecular genetics and genomics : MGG	2024	Signature and function of plasma exosome-derived circular RNAs in patients with hypertensive intracerebral hemorrhage.	hsa_circ_0051021		hsa_circ_TIMM50	TIMM50	hypertensive intracerebral hemorrhage 	MONDO:0013792	intracerebral hemorrhage	up-regulated	Microarray	hsa_circ_0051021 is an up-regulated plasma exosomal circRNA in HICH. It was strongly correlated with bleeding volume and GCS score and was included in the predicted ceRNA network.	0.348
38734849	Molecular genetics and genomics : MGG	2024	Signature and function of plasma exosome-derived circular RNAs in patients with hypertensive intracerebral hemorrhage.	hsa_circ_0090516	hsa_circ_00090516	hsa_circ_HDAC6	HDAC6	hypertensive intracerebral hemorrhage 	MONDO:0013792	intracerebral hemorrhage	down-regulated	Microarray	"hsa_circ_0090516, also referred to as hsa_circ_00090516, is down-regulated in plasma exosomes from HICH patients. The paper predicts that its reduction may suppress TRAF7 through miR-1197, impairing endothelial integrity and contributing to hemorrhage severity."	0.348
38734849	Molecular genetics and genomics : MGG	2024	Signature and function of plasma exosome-derived circular RNAs in patients with hypertensive intracerebral hemorrhage.	hsa_circ_0009456		hsa_circ_NPHP4	NPHP4	hypertensive intracerebral hemorrhage 	MONDO:0013792	intracerebral hemorrhage	down-regulated	Microarray	hsa_circ_0009456 is a down-regulated plasma exosomal circRNA in HICH. It correlated negatively with bleeding volume and positively with GCS score and was included in the predicted ceRNA network.	0.348
38734849	Molecular genetics and genomics : MGG	2024	Signature and function of plasma exosome-derived circular RNAs in patients with hypertensive intracerebral hemorrhage.	hsa_circ_0103819		hsa_circ_DMXL2	DMXL2	hypertensive intracerebral hemorrhage 	MONDO:0013792	intracerebral hemorrhage	down-regulated	Microarray	hsa_circ_0103819 is a down-regulated plasma exosomal circRNA in HICH. It correlated with bleeding volume and GCS score and was analyzed in predicted ceRNA networks.	0.348
38734849	Molecular genetics and genomics : MGG	2024	Signature and function of plasma exosome-derived circular RNAs in patients with hypertensive intracerebral hemorrhage.	hsa_circ_0099180		hsa_circ_TBC1D15	TBC1D15	hypertensive intracerebral hemorrhage 	MONDO:0013792	intracerebral hemorrhage	down-regulated	Microarray	hsa_circ_0099180 is a down-regulated plasma exosomal circRNA in HICH. It showed clinical severity correlations and was included in predicted circRNA-miRNA-mRNA analyses.	0.348
38734849	Molecular genetics and genomics : MGG	2024	Signature and function of plasma exosome-derived circular RNAs in patients with hypertensive intracerebral hemorrhage.	hsa_circ_0010493		hsa_circ_EIF4G3	EIF4G3	hypertensive intracerebral hemorrhage 	MONDO:0013792	intracerebral hemorrhage	down-regulated	Microarray	hsa_circ_0010493 is a down-regulated plasma exosomal circRNA in HICH. It was associated with bleeding volume and GCS score and was predicted to regulate endothelial senescence-related E2F2 through miR-23b-5p.	0.348
38743320	Cardiovascular toxicology	2024	Circ_0002331 Interacts with ELAVL1 to Improve ox-LDL-Induced Vascular Endothelial Cell Dysfunction via Regulating CCND2 mRNA Stability.	hsa_circ_0002331	circ_0002331	hsa_circ_FBXW8	FBXW8	atherosclerosis 	MONDO:0005311	atherosclerosis	down-regulated	RT-qPCR	"circ_0002331 is downregulated in AS patient serum and ox-LDL-induced HUVECs. It protects endothelial cells from ox-LDL-induced dysfunction by interacting with ELAVL1 to stabilize CCND2 mRNA, promoting proliferation, migration, invasion and angiogenesis while inhibiting apoptosis, autophagy and inflammation. Its serum level also shows potential diagnostic value for AS."	0.8442
38743820	Systems biology in reproductive medicine	2024	FOXA1 co-activates circODC1 and ODC1 in HPV-positive cervical cancer cell growth.	hsa_circ_0052602	circODC1	hsa_circ_ODC1	ODC1	HPV-positive cervical cancer 	MONDO:0005131	cervical carcinoma	up-regulated	RT-qPCR	"CircODC1 (hsa_circ_0052602) is up-regulated in HPV-positive cervical cancer cell lines and functions as an oncogenic circRNA. FOXA1 activates circODC1 transcription, and circODC1 promotes malignant cell growth by sponging miR-607 to relieve repression of its host gene ODC1."	0.8164
38744073	Clinics and research in hepatology and gastroenterology	2024	A comprehensive evaluation of serum circCSPP1 as a novel diagnostic and prognostic biomarker for gastric cancer.	hsa_circ_0001806	hsa_circCSPP1_041 	hsa_circ_CSPP1	CSPP1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"circCSPP1 (hsa_circ_0001806) is an exonic circRNA derived from CSPP1 and is up-regulated in gastric cancer tissues, serum, and cell lines. The study supports serum circCSPP1 as a non-invasive diagnostic, recurrence-monitoring, and prognostic biomarker for gastric cancer, with high expression associated with poor survival and advanced clinicopathological features. Mechanistically, circCSPP1 is mainly cytoplasmic and the authors predicted a circCSPP1-miRNA-mRNA ceRNA regulatory network, but downstream interactions were bioinformatically predicted rather than experimentally validated."	0.7297
38747924	Clinical laboratory	2024	Hsa_Circ_0002762 may be a New Marker for the Gastric Cancer Diagnosis and Prognosis.	hsa_circ_0002762				gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"hsa_circ_0002762 is up-regulated in gastric cancer tissues, plasma, and selected GC cell lines, and may act as an oncogenic circRNA. Clinically, its plasma level shows diagnostic value, improves sensitivity when combined with CEA and CA19-9, and high expression is associated with poorer survival. Mechanistically, the study suggests a cytoplasmic post-transcriptional ceRNA network involving hsa_circ_0002762 and five predicted/validated miRNAs."	0.5734
38750769	Biochimica et biophysica acta. Molecular basis of disease	2024	Circ_0006949 as a potential non-invasive diagnosis biomarker promotes the proliferation of NSCLC cells via miR-4673/GLUL axis.	hsa_circ_0006949	circ_0006949 	hsa_circ_GLUL	GLUL	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"Circ_0006949 is up-regulated in sputum and tumor tissues from NSCLC patients and serves as a potential non-invasive biomarker for early diagnosis and therapeutic monitoring. Functionally, cytoplasmic circ_0006949 promotes NSCLC proliferation, colony formation, migration, invasion and xenograft tumor growth, while suppressing apoptosis signaling. Mechanistically, it acts as a ceRNA for miR-4673 to upregulate GLUL, enhancing GLUL catalytic activity and glutamine-related metabolism."	0.8457
38750769	Biochimica et biophysica acta. Molecular basis of disease	2024	Circ_0006949 as a potential non-invasive diagnosis biomarker promotes the proliferation of NSCLC cells via miR-4673/GLUL axis.	hsa_circ_0006949	circ_0006949 	hsa_circ_GLUL	GLUL	 lung adenocarcinoma	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"Circ_0006949 is up-regulated in sputum and tumor tissues from NSCLC patients and serves as a potential non-invasive biomarker for early diagnosis and therapeutic monitoring. Functionally, cytoplasmic circ_0006949 promotes NSCLC proliferation, colony formation, migration, invasion and xenograft tumor growth, while suppressing apoptosis signaling. Mechanistically, it acts as a ceRNA for miR-4673 to upregulate GLUL, enhancing GLUL catalytic activity and glutamine-related metabolism."	0.8457
38750769	Biochimica et biophysica acta. Molecular basis of disease	2024	Circ_0006949 as a potential non-invasive diagnosis biomarker promotes the proliferation of NSCLC cells via miR-4673/GLUL axis.	hsa_circ_0006949	circ_0006949 	hsa_circ_GLUL	GLUL	 lung large cell carcinoma	MONDO:0003050	lung large cell carcinoma	up-regulated	RT-qPCR; Microarray	"Circ_0006949 is up-regulated in sputum and tumor tissues from NSCLC patients and serves as a potential non-invasive biomarker for early diagnosis and therapeutic monitoring. Functionally, cytoplasmic circ_0006949 promotes NSCLC proliferation, colony formation, migration, invasion and xenograft tumor growth, while suppressing apoptosis signaling. Mechanistically, it acts as a ceRNA for miR-4673 to upregulate GLUL, enhancing GLUL catalytic activity and glutamine-related metabolism."	0.8457
38750769	Biochimica et biophysica acta. Molecular basis of disease	2024	Circ_0006949 as a potential non-invasive diagnosis biomarker promotes the proliferation of NSCLC cells via miR-4673/GLUL axis.	hsa_circ_0006949	circ_0006949 	hsa_circ_GLUL	GLUL	lung squamous cell carcinoma 	MONDO:0005097	squamous cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"Circ_0006949 is up-regulated in sputum and tumor tissues from NSCLC patients and serves as a potential non-invasive biomarker for early diagnosis and therapeutic monitoring. Functionally, cytoplasmic circ_0006949 promotes NSCLC proliferation, colony formation, migration, invasion and xenograft tumor growth, while suppressing apoptosis signaling. Mechanistically, it acts as a ceRNA for miR-4673 to upregulate GLUL, enhancing GLUL catalytic activity and glutamine-related metabolism."	0.8457
38751015	Molecular carcinogenesis	2024	M6A-mediated hsa_circ_0061179 inhibits DNA damage in ovarian cancer cells via miR-143-3p/TIMELESS.	hsa_circ_0061179	circZBTB46	hsa_circ_ZBTB46	ZBTB46	Ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0061179/circZBTB46 is up-regulated in ovarian cancer and high expression is associated with poorer survival and more advanced clinicopathological features. Mechanistically, METTL3-mediated m6A modification enhances hsa_circ_0061179 expression and stability, YTHDC1 promotes its cytoplasmic export, and cytoplasmic hsa_circ_0061179 sponges miR-143-3p to increase TIMELESS and activate ATR/CHK1-related DNA damage repair signaling, thereby promoting proliferation, migration and tumor growth while inhibiting apoptosis and DNA damage."	0.8933
38754565	Microbial pathogenesis	2024	Whole-transcriptome sequencing of phagocytes reveals a ceRNA network contributing to natural resistance to tuberculosis infection.		hsa-ATAD3A_0003	hsa_circ_ATAD3A	ATAD3A	tuberculosis 	MONDO:0018076	tuberculosis	dysregulated	RT-qPCR; RNA-seq	hsa-ATAD3A_0003 was identified in the circRNA-miRNA-mRNA ceRNA network and validated by qRT-PCR as differentially expressed between Resisters and LTBI patients. The study proposes that its association with CYP17A1 may participate in immune-metabolic regulation underlying natural resistance to TB infection.	0.4032
38754565	Microbial pathogenesis	2024	Whole-transcriptome sequencing of phagocytes reveals a ceRNA network contributing to natural resistance to tuberculosis infection.		hsa-XXbac-BPG248L24_0001			tuberculosis 	MONDO:0018076	tuberculosis	up-regulated	RNA-seq	hsa-XXbac-BPG248L24_0001 was reported as the most significantly upregulated circRNA in phagocytes from Resisters compared with LTBI patients. The paper did not provide qRT-PCR validation or mechanistic experiments specifically for this circRNA.	0.1768
38754565	Microbial pathogenesis	2024	Whole-transcriptome sequencing of phagocytes reveals a ceRNA network contributing to natural resistance to tuberculosis infection.		hsa-LILRB1_0011	hsa_circ_LILRB1	LILRB1	tuberculosis 	MONDO:0018076	tuberculosis	down-regulated	RNA-seq	hsa-LILRB1_0011 was reported as the most downregulated circRNA in phagocytes from Resisters compared with LTBI patients. The paper did not provide qRT-PCR validation or mechanistic experiments specifically for this circRNA.	0.1768
38755468	Molecular biotechnology	2025	Involvement of circ_0029407 in Caerulein-Evoked Cytotoxicity in Human Pancreatic Cells via the miR-579-3p/TLR4/NF-kappaB Pathway.	hsa_circ_0029407	circ_0029407 	hsa_circ_GLT1D1	GLT1D1	Acute pancreatitis 	MONDO:0006515	acute pancreatitis	up-regulated	RT-qPCR	"circ_0029407 is up-regulated in serum from AP patients and in caerulein-stimulated human pancreatic epithelial cells. Functionally, circ_0029407 aggravates caerulein-induced pancreatic cell injury by suppressing viability/proliferation and promoting apoptosis and inflammatory responses. Mechanistically, it acts as a ceRNA for miR-579-3p to increase TLR4 expression and activate TLR4/NF-kappaB signaling, suggesting potential diagnostic and therapeutic relevance in AP."	0.7591
38759738	Gene	2024	circCUL3 drives malignant progression of cervical cancer by activating autophagy through sponge miR-223-3p upregulation of ATG7.		circCUL3 	hsa_circ_CUL3	CUL3	cervical cancer	MONDO:0002974	cervical cancer	unknown	RT-qPCR	"This study identifies circCUL3 as an oncogenic circRNA in cervical cancer models. circCUL3 sponges miR-223-3p to increase ATG7 expression and activate autophagy, thereby promoting proliferation, migration, invasion, EMT and tumor growth while inhibiting apoptosis. The autophagy inhibitor chloroquine partially counteracts circCUL3-driven oncogenic effects."	0.6542
38760544	Acta pharmacologica Sinica	2024	CircNSD1 promotes cardiac fibrosis through targeting the miR-429-3p/SULF1/Wnt/beta-catenin signaling pathway.		circ-0000465 	mmu_circ_NSD1	NSD1	cardiac fibrosis 	MONDO:0005267	heart disorder	up-regulated	RT-qPCR	"Mouse circNSD1 is up-regulated in MI hearts and TGF-beta1-induced mouse cardiac fibroblasts. It promotes cardiac fibrosis by sponging miR-429-3p, increasing SULF1 expression, activating Wnt/beta-catenin signaling, and enhancing fibroblast proliferation and collagen deposition."	0.7918
38760544	Acta pharmacologica Sinica	2024	CircNSD1 promotes cardiac fibrosis through targeting the miR-429-3p/SULF1/Wnt/beta-catenin signaling pathway.		human circNSD1 	hsa_circ_NSD1	NSD1	cardiac fibrosis 	MONDO:0005267	heart disorder	up-regulated	RT-qPCR	"Human h-circNSD1 is an ortholog of mouse circNSD1 and is up-regulated in TGF-beta1-induced human cardiac fibroblasts. Knockdown suppresses fibrosis-related gene expression and proliferation, whereas overexpression increases FN1, Col1alpha1 and Col3alpha1 levels and facilitates HCF proliferation."	0.5925
38762192	Cancer letters	2024	Circular RNA circHIPK2 inhibits colon cancer cells through miR-373-3p/RGMA axis.	hsa_circ_0001756	circHIPK2	hsa_circ_HIPK2	HIPK2	colon cancer	MONDO:0021063	malignant colon neoplasm	down-regulated	RT-qPCR; ISH; Microarray	"circHIPK2 is a human HIPK2-derived circRNA downregulated in colon cancer. It suppresses colon cancer proliferation, migration, invasion, tumor growth, and metastasis by sponging miR-373-3p, thereby increasing RGMA and activating BMP/Smad signaling. Clinically, low circHIPK2 expression is associated with higher tumor grade/stage and poorer survival, supporting its potential diagnostic and prognostic value."	0.8999
38764269	Yi chuan = Hereditas	2023	Hsa_circ_0007460 affects the survival of intracellular Mycobacterium tuberculosis by regulating autophagy and apoptosis of macrophages.	hsa_circ_0007460		hsa_circ_GOSR1	GOSR1	active pulmonary tuberculosis 	MONDO:0006052	pulmonary tuberculosis	up-regulated	RT-qPCR	"hsa_circ_0007460 is significantly up-regulated in peripheral blood/PBMCs from ATB/TB patients and in BCG-infected THP-1 human macrophages, and it shows potential diagnostic value. Functionally, it promotes macrophage apoptosis, inhibits macrophage autophagy, and thereby promotes intracellular BCG survival. The proposed mechanism is a predicted ceRNA axis involving hsa_circ_0007460/hsa-miR-3127-5p/PATZ1."	0.7745
38764323	"Genesis (New York, N.Y. : 2000)"	2024	"CircSCNN1A inhibits the proliferation, migration and invasion of renal cell carcinoma cells by decreasing CLDN8 expression through miR-590-5p."	hsa_circ_0025135	circSCNN1A 	hsa_circ_SCNN1A	SCNN1A	renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	down-regulated	RT-qPCR; Microarray	"CircSCNN1A is downregulated in renal cell carcinoma tissues and cells. In this study, circSCNN1A acted as a tumor-suppressive circRNA by sponging miR-590-5p, increasing CLDN8 expression, and inhibiting RCC cell proliferation, migration, invasion, EMT-related marker changes and xenograft tumor growth."	0.8439
38775215	Environmental toxicology	2024	Downregulation of circ-RAPGEF5 inhibits colorectal cancer progression by reducing the expression of polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3).	hsa_circ_0001681	circ-RAPGEF5	hsa_circ_RAPGEF5	RAPGEF5	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ-RAPGEF5 is a human circRNA derived from RAPGEF5 that is upregulated in CRC tissues and cells. It promotes malignant CRC phenotypes by sponging miR-545-5p and relieving miR-545-5p-mediated repression of GALNT3, thereby enhancing proliferation, migration, invasion, and in vivo tumor growth while suppressing apoptosis. The study suggests circ-RAPGEF5 as a potential biomarker and therapeutic target in CRC."	0.8635
38776052	Biochemical genetics	2025	Silencing of circRPPH1 Inhibits the Progression of Non-Small-Cell Lung Cancer Through miR-326/ERBB4 Signal Axis.	hsa_circ_0000517	circRPPH1 	hsa_circ_RPPH1	RPPH1	non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circRPPH1 is up-regulated in NSCLC tissues and cells and is associated with advanced TNM stage, lymphatic metastasis, and poor overall survival. Functionally, circRPPH1 promotes NSCLC cell proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, it acts through a ceRNA mechanism by sponging miR-326 and regulating ERBB4 expression via the miR-326/ERBB4 axis."	0.8914
38780005	Journal of biochemical and molecular toxicology	2024	circ_0000592 facilitates the progression of esophageal squamous cell carcinoma via miR-155-5p/FZD5 axis.	hsa_circ_0000592	circ_0000592 			esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ_0000592 is up-regulated in ESCC tissues and cell lines, and high expression correlates with worse overall survival, advanced TNM stage, and lymph node metastasis. Functionally, circ_0000592 promotes ESCC proliferation, stemness, migration, invasion, tumor growth, and metastasis. Mechanistically, cytoplasmic circ_0000592 sponges miR-155-5p to relieve repression of FZD5 protein expression."	0.8554
38787443	Archives of dermatological research	2024	"WTAP mediated m6A-modified circ_0056856 contributes to the proliferation, migration, and invasion of IL-22-stimulated human keratinocyte by miR-197-3p/CDK1 axis."	hsa_circ_0056856	circ_0056856	hsa_circ_ITGB6	ITGB6	psoriasis	MONDO:0005083	psoriasis	up-regulated	RT-qPCR	"circ_0056856 is up-regulated in psoriasis patient skin samples and IL-22-stimulated HaCaT keratinocytes. WTAP-mediated m6A modification enhances circ_0056856 stability, and circ_0056856 promotes IL-22-induced keratinocyte proliferation, migration, and invasion through the miR-197-3p/CDK1 ceRNA axis."	0.7795
38797004	"Comparative biochemistry and physiology. Part D, Genomics & proteomics"	2024	Systematic identification and analysis of immune-related circRNAs of Pelteobagrus fulvidraco involved in Aeromonas veronii infection.		novel_circ_000226 		ADAMTS13	Aeromonas veronii infection 	MONDO:1014952		dysregulated	RT-qPCR; RNA-seq	"novel_circRNA_000226 was identified as an immune-related differentially expressed circRNA during A. veronii infection in yellow catfish. It is linked to ADAMTS13-mediated platelet activation and was predicted to interact with miR-29-z, suggesting a role in inflammatory immune responses."	0.3684
38797004	"Comparative biochemistry and physiology. Part D, Genomics & proteomics"	2024	Systematic identification and analysis of immune-related circRNAs of Pelteobagrus fulvidraco involved in Aeromonas veronii infection.		novel_circ_000278 		HAMP1	Aeromonas veronii infection 	MONDO:1014952		dysregulated	RT-qPCR; RNA-seq	"novel_circRNA_000278 is an immune-related differentially expressed circRNA induced by A. veronii infection. It is linked to HAMP1 and antibacterial defense responses, and the authors suggest it may protect the host by reducing bacterial burden."	0.3684
38797004	"Comparative biochemistry and physiology. Part D, Genomics & proteomics"	2024	Systematic identification and analysis of immune-related circRNAs of Pelteobagrus fulvidraco involved in Aeromonas veronii infection.		novel_circ_000401 		ANG3	Aeromonas veronii infection 	MONDO:1014952		dysregulated	RT-qPCR; RNA-seq	"novel_circRNA_000401 is an immune-related DEcir induced by A. veronii infection. It is linked to ANG3-mediated antibacterial and antimicrobial humoral responses and was predicted to target multiple miRNAs, suggesting broad immunomodulatory roles."	0.3684
38797004	"Comparative biochemistry and physiology. Part D, Genomics & proteomics"	2024	Systematic identification and analysis of immune-related circRNAs of Pelteobagrus fulvidraco involved in Aeromonas veronii infection.		novel_circ_000522 		APOA1	Aeromonas veronii infection 	MONDO:1014952		dysregulated	RT-qPCR; RNA-seq	"novel_circRNA_000522 was identified as an immune-related circRNA during A. veronii infection. It is linked to APOA1 regulation, platelet activation, and antibacterial defenses, and was predicted to interact with two miRNAs."	0.3684
38797004	"Comparative biochemistry and physiology. Part D, Genomics & proteomics"	2024	Systematic identification and analysis of immune-related circRNAs of Pelteobagrus fulvidraco involved in Aeromonas veronii infection.		novel_circ_000736 		FGB	Aeromonas veronii infection 	MONDO:1014952		dysregulated	RT-qPCR; RNA-seq	novel_-circRNA_000736 was identified as an immune-related differentially expressed circRNA in A. veronii-infected yellow catfish. It interacts with FGB and is linked to platelet activation and antimicrobial humoral response pathways.	0.3684
38797004	"Comparative biochemistry and physiology. Part D, Genomics & proteomics"	2024	Systematic identification and analysis of immune-related circRNAs of Pelteobagrus fulvidraco involved in Aeromonas veronii infection.		novel_circ_000843 		RALGPS1	Aeromonas veronii infection 	MONDO:1014952		dysregulated	RT-qPCR; RNA-seq	"novel_circRNA_000843 was identified as an immune-related DEcir in A. veronii-infected yellow catfish. It is paired with RALGPS1 and associated with regulation of Ral protein signal transduction, a pathway discussed as relevant to bacterial clearance."	0.3684
38797004	"Comparative biochemistry and physiology. Part D, Genomics & proteomics"	2024	Systematic identification and analysis of immune-related circRNAs of Pelteobagrus fulvidraco involved in Aeromonas veronii infection.		novel_circ_000975 		ANG3	Aeromonas veronii infection 	MONDO:1014952		dysregulated	RT-qPCR; RNA-seq	"novel_circRNA_000975 is an immune-related differentially expressed circRNA during A. veronii infection in yellow catfish. It is linked to ANG3 and implicated in antibacterial and antimicrobial humoral response pathways, with a proposed role in promoting host defense."	0.3684
38802299	Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology	2024	circMTO1/miR-30c-5p/SOCS3 axis alleviates oral submucous fibrosis through inhibiting fibroblast-myofibroblast transition.		circRNA mitochondrial translation optimization 1 homologue (circMTO1) 	hsa_circ_MTO1	MTO1	oral submucous fibrosis 	MONDO:0018166	oral submucous fibrosis	down-regulated	RT-qPCR	"circMTO1 is down-regulated in OSF tissues and arecoline-stimulated BMFs. Its overexpression suppresses fibroblast-myofibroblast transition, migration, and invasion by sponging miR-30c-5p to enhance SOCS3 expression and inactivate the FAK/PI3K/AKT pathway, suggesting a potential therapeutic role in OSF."	0.7944
38802550	Cancer gene therapy	2024	CircPKN2 promotes ferroptosis in bladder cancer by promoting the ubiquitination of Stearoyl-CoA Desaturase 1.	hsa_circ_0013093	circPKN2	hsa_circ_PKN2	PKN2	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; ISH; RNA-seq	"circPKN2/hsa_circ_0013093 is significantly downregulated in bladder cancer and high expression predicts better OS and DFS. Functionally, circPKN2 suppresses BC proliferation, migration, invasion, EMT, tumor growth and metastasis by promoting ferroptosis. Mechanistically, QKI promotes circPKN2 biogenesis, and circPKN2 recruits STUB1 to enhance SCD1 ubiquitination and degradation, thereby inhibiting the WNT pathway."	0.8913
38802551	Cancer gene therapy	2024	Hsa_circ_0007590/PTBP1 complex reprograms glucose metabolism by reducing the stability of m6A-modified PTEN mRNA in pancreatic ductal adenocarcinoma.	hsa_circ_0007590	hsa_-circ_0007590	hsa_circ_LATS2	LATS2	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"hsa_circ_0007590 is up-regulated in PDAC tissues and cell lines and high expression predicts poor prognosis. Functionally, it promotes proliferation, migration, invasion, xenograft growth, and glycolytic metabolism. Mechanistically, it forms a complex with PTBP1, increases YTHDF2 expression/stability, reduces m6A-modified PTEN mRNA stability, and activates PI3K/AKT/mTOR signaling."	0.8957
38805063	Science China. Life sciences	2024	CircZFR promotes colorectal cancer progression via stabilizing BCLAF1 and regulating the miR-3127-5p/RTKN2 axis.	hsa_circ_0072088	circZFR	hsa_circ_ZFR	ZFR	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; Microarray	"CircZFR is an up-regulated oncogenic circRNA in colorectal cancer tissues and serum exosomes, associated with advanced stage, metastasis, diagnostic value, and poor overall survival. Functionally, it promotes CRC proliferation, migration, invasion, tumor growth and metastasis while inhibiting apoptosis. Mechanistically, ESRP1 enhances circZFR biogenesis, circZFR stabilizes BCLAF1 by preventing ubiquitin-proteasome degradation, and circZFR acts as a sponge for miR-3127-5p to increase RTKN2 expression."	0.9007
38810361	Cancer genetics	2024	SP1-induced circ_0017552 modulates colon cancer cell proliferation and apoptosis via up-regulation of NET1.	hsa_circ_0017552	circ_0017552	hsa_circ_NET1	NET1	colon cancer 	MONDO:0021063	malignant colon neoplasm	up-regulated	RT-qPCR	"In this study, circ_0017552 was up-regulated in colon cancer cells and functioned as an oncogenic circRNA. SP1 induced circ_0017552 transcription, and circ_0017552 sponged miR-338-3p to increase NET1 expression, thereby promoting proliferation and invasion while inhibiting apoptosis in colon cancer cells."	0.7902
38811210	The Tohoku journal of experimental medicine	2024	"Circular RNA DLGAP4 Inhibits Ischemic Stroke-Induced Microglia M1 Polarization and Proinflammatory Cytokine Production, Possibly through the NF-kappaB Pathway."		Circular RNA DLGAP4 	mmu_circ_DLGAP4	DLGAP4	ischemic stroke 	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR	"In an OGD/R-induced BV-2 microglial ischemic stroke model, circ_DLGAP4 was down-regulated. Its overexpression suppressed microglial M1 polarization and proinflammatory cytokine production, promoted M2-associated markers and anti-inflammatory cytokine production, and inactivated the NF-kappaB pathway, suggesting a protective role in ischemic stroke injury."	0.5223
38813926	"Shock (Augusta, Ga.)"	2024	A NOVEL CIRC_SUPT3/MIR-185-5P/G3BP2 CERNA NETWORK REGULATES HIGH GLUCOSE-INDUCED INJURY IN MOUSE PODOCYTE MPC5 CELLS.		circ_Supt3	mmu_circ_Supt3	Supt3	Diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"circ_Supt3 is up-regulated in DN mouse renal tissues and HG-treated mouse podocyte MPC5 cells. Functionally, circ_Supt3 promotes HG-induced podocyte injury by suppressing proliferation and enhancing apoptosis and inflammatory responses. Mechanistically, it acts as a ceRNA for miR-185-5p to positively regulate G3bp2 expression, and its knockdown may protect podocytes from HG-stimulated injury."	0.7221
38814199	"Cellular and molecular biology (Noisy-le-Grand, France)"	2024	N6-Methyladenosine modified circ-NAB1 modulates cell cycle and epithelial-mesenchymal transition via CDKN3 in endometrial cancer.	hsa_circ_0002024	Circ-NAB1	hsa_circ_NAB1		Endometrial cancer 	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR; RNA-seq	"Circ-NAB1 is upregulated in endometrial cancer tissues and cells and acts as an oncogenic circRNA. ALKBH5-mediated m6A regulation stabilizes and increases circ-NAB1 through a YTHDF2-dependent mechanism. Cytoplasmic circ-NAB1 sponges miR-876-3p to upregulate CDKN3, promoting proliferation, migration, invasion, EMT, and cell cycle progression in EC cells."	0.813
38814210	"Cellular and molecular biology (Noisy-le-Grand, France)"	2024	Circular RNA circ_0006168 accelerates the development of hepatocellular carcinoma through sponging microRNA-125b.	hsa_circ_0006168	circ_0006168			hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ_0006168 is up-regulated in HCC tissues and cell lines and is associated with advanced pathological stage and poor overall survival. Functionally, circ_0006168 promotes HCC cell proliferation and suppresses apoptosis. Mechanistically, it binds and negatively regulates microRNA-125b, contributing to malignant progression of HCC."	0.7618
38814217	"Cellular and molecular biology (Noisy-le-Grand, France)"	2024	Circular RNA Circ_0001322 inhibits gastric cancer progression by modulating the miR-1264/QKI axis and suppressing the Hedgehog pathway.	hsa_circ_0001322	circ1322 	hsa_circ_EIF4E3	EIF4E3	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"hsa_circ_0001322/circ1322 is down-regulated in gastric cancer tissues and cell lines. Its upregulation suppresses GC proliferation, migration, invasion and xenograft tumor growth while promoting apoptosis. Mechanistically, circ1322 functions as a ceRNA sponge for miR-1264, increases QKI expression, and suppresses Hedgehog pathway activity, suggesting potential biomarker value in GC."	0.7595
38819599	Molecular and cellular biochemistry	2025	CircZNF609 sponges miR-135b to up-regulate SEMA3A expression to alleviate ox-LDL-induced atherosclerosis.		circZNF609	hsa_circ_ZNF609	ZNF609	atherosclerosis 	MONDO:0005311	atherosclerosis	down-regulated	RT-qPCR	"circZNF609 is down-regulated in AS patients and ox-LDL-stimulated macrophage models. Its overexpression protects against atherosclerosis-associated lipid accumulation, inflammation, mitochondrial dysfunction, necrosis, apoptosis, and cell death by sponging miR-135b and increasing SEMA3A expression."	0.7552
38822975	Cell biochemistry and biophysics	2024	To investigate the role and potential mechanism of has_circ_RBMS3 in bone metastasis of breast cancer based on bioinformatics.	hsa_circ_0064644		hsa_circ_RBMS3	RBMS3	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"CircRBMS3 is upregulated in bone metastasis breast cancer and high expression is associated with shorter 3-year overall survival. Functionally, circRBMS3 promotes breast cancer cell proliferation, migration, invasion, and bone metastasis-related osteoclast/bone resorption gene expression. Mechanistically, the study proposes a circRBMS3-miR-654-3p-mRNA ceRNA network, with AKT1 highlighted as a potential downstream hub."	0.7513
38824399	Carcinogenesis	2024	Exosomal circPVT1 promotes angiogenesis in laryngeal cancer by activating the Rap1b-VEGFR2 signaling pathway.		circPVT1	hsa_circ_PVT1	PVT1	laryngeal cancer 	MONDO:0002358	laryngeal carcinoma	up-regulated	RT-qPCR	"circPVT1 is upregulated in laryngeal cancer tissues, cell lines and patient plasma/serum exosomes, and high expression is associated with disease progression and poorer survival. LC cell-derived exosomal circPVT1 is transferred to endothelial cells, where it sponges miR-30c-5p to increase Rap1b and activate VEGFR2/PI3K/AKT signaling, promoting angiogenesis. Targeting circPVT1 suppresses tumor growth and angiogenesis and may improve the therapeutic effect of cetuximab."	0.8558
38830562	Cellular signalling	2024	hsa_circ_0000518 stimulates the malignant progression of hepatocellular carcinoma via regulating ITGA5 to activate the Warburg effect.	hsa_circ_0000518	circ_0000518 	hsa_circ_RPPH1	RPPH1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"hsa_circ_0000518/circ_0000518 is up-regulated in HCC clinical tissues and cell lines and acts as a pro-oncogenic circRNA. It promotes proliferation, migration, invasion, xenograft tumor growth and Warburg-effect-related glycolysis while inhibiting apoptosis. Mechanistically, it increases ITGA5 via both miR-326 sponging and HuR-mediated ITGA5 mRNA stabilization, suggesting diagnostic and therapeutic relevance in HCC."	0.8571
38841987	Histology and histopathology	2025	Hsa_circ_0070440 mediates the prognosis and progress of human prostate cancer.	hsa_circ_0070440		hsa_circ_FAM13A	FAM13A	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"hsa_circ_0070440 is up-regulated in prostate cancer tissues and cell lines, with higher levels in CRPC than non-CRPC cases. Its high expression predicts poor OS, TTPP, and TTF, and functional assays indicate that it promotes PCa cell proliferation and migration. Mechanistically, it may sponge miR-382-5p and miR-383-5p and participate in a miR-382/383-5p/TXNDC5 regulatory axis."	0.7283
38842024	Environmental toxicology	2024	CircVCAN promotes glioma progression through the miR-488-3p/MEF2C-JAGGED1 axis.		CircVCAN 	hsa_circ_VCAN	VCAN	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR	"CircVCAN is up-regulated and predominantly cytoplasmic in glioma tissues and cells. It promotes glioma proliferation, migration, invasion, EMT-related malignant phenotypes, and in vivo tumor growth by sponging miR-488-3p to regulate MEF2C and downstream JAGGED1 transcriptional signaling. The circVCAN/miR-488-3p/MEF2C-JAGGED1 axis is proposed as a potential therapeutic target for glioma."	0.8682
38842177	"Tissue engineering. Part C, Methods"	2024	Young TSPC-Derived Exosomal circPVT1 Ameliorates Aging-Impaired Cell Function via SIRT1/NF-kappaB.		circPVT1	hsa_circ_PVT1	PVT1	age-dependent tendon diseases 			unknown	RT-qPCR	"This study shows that exosomal circPVT1 from young TSPCs can rescue aging-impaired L-TSPC phenotypes by promoting proliferation, self-renewal, stemness, and tenogenic differentiation while reducing senescence and osteogenic differentiation. Mechanistically, circPVT1-exo acts through upregulation of SIRT1 and suppression of NF-kappaB activation, suggesting a potential exosome-based therapeutic strategy for age-related tendon diseases."	0.421
38842772	Current medical science	2024	Circ_0012152 Accelerates Acute Myeloid Leukemia Progression through the miR-652-3p/SOX4 Axis.	hsa_circ_0012152	circ_0012152 			acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"circ_0012152/hsa_circ_0012152 is upregulated in AML bone marrow samples and high expression predicts worse overall survival. Functionally, circ_0012152 promotes AML cell growth, suppresses apoptosis, and supports cell cycle progression. Mechanistically, it is mainly cytoplasmic and acts as a miR-652-3p sponge to promote SOX4 expression, with transcriptome analyses suggesting links to Wnt and PI3K/Akt signaling."	0.8143
38847033	Fa yi xue za zhi	2024	Biomarkers Screening and Mechanisms Analysis of the Restraint Stress-Induced Myocardial Injury in Hyperlipidemia ApoE-/- Mice.	mmu_circ_0001567				chronic restraint stress-induced myocardial injury in hyperlipidemia ApoE-	MONDO:0024643	myocardial disorder	up-regulated	RT-qPCR	mmu_circ_0001567 was up-regulated in myocardial tissue of hyperlipidemia ApoE-/- mice exposed to restraint stress. The study predicted that mmu_circ_0001567 may act through a mmu_circ_0001567/miR-7a/Tfr-1 ceRNA axis associated with TFR1-related ferroptosis and myocardial injury.	0.31
38847033	Fa yi xue za zhi	2024	Biomarkers Screening and Mechanisms Analysis of the Restraint Stress-Induced Myocardial Injury in Hyperlipidemia ApoE-/- Mice.	mmu_circ_0001042				chronic restraint stress-induced myocardial injury in hyperlipidemia ApoE-	MONDO:0024643	myocardial disorder	up-regulated	RT-qPCR	mmu_circ_0001042 was up-regulated in myocardial tissue of hyperlipidemia ApoE-/- mice exposed to restraint stress. The study predicted that mmu_circ_0001042 may act through a mmu_circ_0001042/miR-7a/Tfr-1 ceRNA axis associated with TFR1-related ferroptosis and myocardial injury.	0.31
38850033	"Journal of chemotherapy (Florence, Italy)"	2025	CircRNA_0044556 affects the sensitivity of triple-negative breast cancer cells to paclitaxel by regulating miR-665.	hsa_circ_0044556	circRNA_0044556 	hsa_circ_COL1A1	COL1A1	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"circRNA_0044556 is up-regulated in TNBC cells and further increased in paclitaxel-resistant MDA-MB-231/PTX cells. It promotes TNBC malignant phenotypes and paclitaxel resistance by acting as a ceRNA for miR-665; knockdown reduces proliferation and colony formation and induces apoptosis, suggesting therapeutic potential in PTX-resistant TNBC."	0.5607
38850300	Naunyn-Schmiedeberg's archives of pharmacology	2024	CircVIRMA enhances cell malignant behavior by governing the miR-452-5p/CREBRF pathway in cervical cancer.	hsa_circ_0084904	circVIRMA 	hsa_circ_VIRMA	VIRMA	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"CircVIRMA is up-regulated in cervical cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation, cell cycle progression, migration, invasion and xenograft tumor growth while suppressing apoptosis, mainly by sponging miR-452-5p to increase CREBRF expression. High circVIRMA expression is associated with more malignant clinicopathologic phenotypes, suggesting potential therapeutic relevance."	0.8572
38850307	Naunyn-Schmiedeberg's archives of pharmacology	2024	Circ_0081723 enhances cervical cancer progression and modulates CREBRF via sponging miR-545-3p.	hsa_circ_0081723	circ_0081723	hsa_circ_POLR2J2	POlR2J2	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ_0081723 is up-regulated in cervical cancer tissues and cell lines and acts as an oncogenic circRNA. It promotes CC cell proliferation, migration, invasion and xenograft tumor growth while suppressing apoptosis, mainly through sponging miR-545-3p to regulate CREBRF. The study suggests circ_0081723 may serve as a biomarker and therapeutic target for cervical cancer."	0.8175
38852653	Brain research bulletin	2024	"Hsa_circ_0049472 contributed to amyloid-beta peptide-induced neurotoxicity, apoptosis and inflammation via regulating PI3K-AKT signaling pathway by interacting with miR-22-3p/ZNF217 axis."	hsa_circ_0049472	circ_0049472	hsa_circ_PRKCSH	PRKCSH	Alzheimer's disease 	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR; Microarray	"hsa_circ_0049472/circ_0049472 is up-regulated in AD-related contexts and in Abeta-treated SK-N-SH neuronal cells. It promotes Abeta-induced neuronal injury, apoptosis and inflammation through a circ_0049472/miR-22-3p/ZNF217 regulatory axis that suppresses PI3K-AKT signaling activation; silencing circ_0049472 exerts neuroprotective effects."	0.7785
38852876	Genomics	2024	Comprehensive analysis of circRNA-miRNA-mRNA regulatory network and novel potential biomarkers in eutopic endometrium of adenomyosis.	hsa_circ_0008959		hsa_circ_CRIM1	CRIM1	adenomyosis 	MONDO:0010888	adenomyosis	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0008959 is significantly down-regulated in eutopic endometrium from ADS patients. The study proposes that it functions as a ceRNA by sponging hsa-miR-124-3p to regulate SLC15A4, thereby participating in proliferation and invasion-related processes and showing diagnostic value for ADS."	0.6238
38852876	Genomics	2024	Comprehensive analysis of circRNA-miRNA-mRNA regulatory network and novel potential biomarkers in eutopic endometrium of adenomyosis.	hsa_circ_0085128				adenomyosis 	MONDO:0010888	adenomyosis	down-regulated	RNA-seq	"hsa_circ_0085128 was identified by circRNA-seq and bioinformatics analysis as a down-regulated circRNA in ADS eutopic endometrium and part of a predicted ceRNA network centered on hsa-miR-124-3p. Its disease association was not positively validated by RT-qPCR, and no specific functional experiments were reported."	0.3528
38852876	Genomics	2024	Comprehensive analysis of circRNA-miRNA-mRNA regulatory network and novel potential biomarkers in eutopic endometrium of adenomyosis.	hsa_circ_0079536				adenomyosis 	MONDO:0010888	adenomyosis	down-regulated	RNA-seq	"hsa_circ_0079536 was identified by circRNA-seq and bioinformatics analysis as a down-regulated circRNA in ADS eutopic endometrium and part of a predicted ceRNA network centered on hsa-miR-124-3p. Its disease association was not positively validated by RT-qPCR in the reported results, and no specific functional experiments were reported."	0.3528
38859827	American journal of cancer research	2024	Expression of circRNA-0036474 in esophageal cancer and its clinical significance.	hsa_circ_0036474				esophageal cancer 	MONDO:0007576	esophageal cancer	up-regulated	RT-qPCR	"hsa_circ_0036474/circRNA-0036474 is up-regulated in EC109 cells and esophageal squamous cell carcinoma tissues. Functionally, it inhibits migration, invasion and EMT of EC109 cells by sponging miR-223-3p and enhancing RERG expression. The study proposes circRNA-0036474 as a potential therapeutic target and non-invasive biomarker candidate for esophageal squamous cell carcinoma."	0.7689
38859856	American journal of cancer research	2024	circBRAF promotes the progression of triple-negative breast cancer through modulating methylation by recruiting KDM4B to histone H3K9me3 and IGF2BP3 to mRNA.	hsa_circ_0007178	circBRAF 	hsa_circ_BRAF	BRAF	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; Microarray	"circBRAF/hsa_circ_0007178 is upregulated in TNBC tissues and TNBC cell lines and acts as an oncogenic circRNA. It promotes proliferation, angiogenesis, migration, invasion, metastasis, and xenograft tumor growth by interacting with IGF2BP3 to enhance mRNA stability of VCAN, FN1, CDCA3, and B4GALT3, and by recruiting KDM4B to regulate H3K9me3-related expression of MMP9 and ADAMTS14. The study proposes circBRAF as a potential therapeutic target for TNBC."	0.8571
38861804	Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy	2024	CircPDIA3/miR-449a/XBP1 feedback loop curbs pyroptosis by inhibiting palmitoylation of the GSDME-C domain to induce chemoresistance of colorectal cancer.	hsa_circ_0002891	circPDIA3 	hsa_circ_PDIA3	PDIA3	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Northern Blot; RNA-seq; Microarray	"circPDIA3 is an upregulated PDIA3-derived circular RNA in CRC, especially in oxaliplatin-resistant tumors, and high expression predicts poorer disease-free survival after OXA-based therapy. Functionally, circPDIA3 promotes chemoresistance by suppressing GSDME-dependent pyroptosis through direct binding to the GSDME-C domain and inhibition of ZDHHC3/ZDHHC17-mediated palmitoylation. It also forms a circPDIA3/miR-449a/XBP1 positive feedback loop that further increases circPDIA3 expression and reinforces OXA resistance."	0.9043
38864460	Journal of leukocyte biology	2024	Crosstalk between circBMI1 and miR-338-5p/ID4 inhibits acute myeloid leukemia progression.	hsa_circ_0093335	circBMI1 	hsa_circ_BMI1	BMI1	acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	down-regulated	RT-qPCR	"circBMI1 is downregulated in AML BMMCs and functions as a tumor-suppressive circRNA. It inhibits AML cell proliferation and in vivo progression, promotes apoptosis, and increases sensitivity to daunorubicin and homoharringtonine through the miR-338-5p/ID4 axis. The study also indicates that circBMI1 can be carried by exosomes and may serve as a diagnostic biomarker and potential therapeutic tool in AML."	0.7878
38867541	"Cell cycle (Georgetown, Tex.)"	2024	Circ_0050444 represses esophageal squamous cell carcinoma progression through sponging miR-486-3p to upregulate C10orf91.	hsa_circ_0050444	Circ_0050444 	hsa_circ_GPATCH1	GPATCH1	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	RT-qPCR	"In this study, circ_0050444 was downregulated in ESCC tissues and cell lines and acted as a tumor suppressor. Its overexpression inhibited ESCC cell proliferation, migration, and invasion by sponging miR-486-3p and increasing C10orf91 expression through a ceRNA mechanism."	0.8088
38869664	Biochemical genetics	2025	"Circ_0000758 Facilitates Bladder Cancer Cell Growth, Migration and Angiogenesis Via Severing as miR-1236-3p Sponge."	hsa_circ_0000758	circ_0000758	hsa_circ_TAF15	TAF15	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circ_0000758 is up-regulated in bladder cancer tissues and cells and acts as an oncogenic circRNA. It promotes BCa cell growth, proliferation, migration, angiogenesis and in vivo tumor growth while inhibiting apoptosis by sponging miR-1236-3p and increasing ZEB2 expression. Its expression is associated with tumor size, TNM stage and lymph node metastasis, suggesting potential therapeutic relevance."	0.8443
38878487	International immunopharmacology	2024	CircZNF609 inhibited bladder cancer immunotherapy sensitivity via enhancing fatty acid uptake through IGF2BP2/CD36 pathway.	hsa_circ_0000615	CircZNF609	hsa_circ_ZNF609	ZNF609	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"CircZNF609 is an oncogenic circRNA studied in bladder cancer that reduces sensitivity to anti-PD-1 immunotherapy and promotes immune escape. It acts through a circZNF609/IGF2BP2/CD36 mechanism, increasing CD36 mRNA stability and fatty acid uptake by cancer cells, thereby depleting fatty acids in the tumour microenvironment and impairing CD8+ T cell function. The study suggests circZNF609 may serve as a biomarker and therapeutic target for bladder cancer immunotherapy."	0.8108
38880656	Biochemistry. Biokhimiia	2024	Gypenoside A Protects Human Myocardial Cells from Ischemia/Reperfusion Injury via the circ_0010729/miR-370-3p/RUNX1 Axis.	hsa_circ_0010729	circ_0010729 			Ischemia	MONDO:0005053	ischemic disease	up-regulated	RT-qPCR	"circ_0010729 is upregulated in OGD/R-induced myocardial I/R injury model cells and counteracts the protective effects of Gypenoside A by reducing cardiomyocyte viability and proliferation and increasing apoptosis. Mechanistically, GP downregulates circ_0010729, decreasing its sponge effect on miR-370-3p, which suppresses RUNX1 expression and promotes cardiomyocyte survival under OGD/R injury."	0.5607
38884150	Environmental toxicology	2024	CircIQCH Contributes to the Progression of Breast Cancer by Elevating NFIB Through Decoying miR-139-5p.	hsa_circ_0104345	circRNA IQ motif containing H 	hsa_circ_IQCH		breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"CircIQCH is up-regulated in breast cancer tissues and cell lines. It acts as an oncogenic circRNA that promotes malignant breast cancer phenotypes and tumor growth by sponging miR-139-5p and elevating NFIB expression, thereby enhancing proliferation, metastasis-related behaviors, cell cycle progression, and autophagy while suppressing apoptosis."	0.7052
38887835	Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology	2024	Circ_0004771 regulates malignant biological behaviors and has clinical significance in oral squamous cell carcinoma.	hsa_circ_0004771	circ_0004771 			oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"hsa_circ_0004771/circ_0004771 is up-regulated in OSCC peripheral blood, cancerous tissues and OSCC cell lines. The study supports an oncogenic role, showing that circ_0004771 promotes proliferation, invasion, EMT and in vivo tumor growth while suppressing apoptosis. Clinically, elevated peripheral blood circ_0004771 showed diagnostic and prognostic value and was associated with recurrence and mortality."	0.6742
38901666	Cancer letters	2024	CircPCNXL2 promotes papillary thyroid carcinoma progression by regulating fatty acid metabolism induced by anabolic enzyme ACC1.	hsa_circ_0000198	circPCNXL2 	hsa_circ_PCNXL2	PCNXL2	papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circPCNXL2 is upregulated in papillary thyroid carcinoma tissues and cell lines and is associated with aggressive clinicopathological features. It promotes PTC proliferation, migration and xenograft tumor growth while suppressing apoptosis, mainly by directly interacting with ACC1 and decreasing ACC1 Ser79 phosphorylation to enhance fatty acid synthesis and lipid metabolism."	0.8541
38904677	"Journal of molecular medicine (Berlin, Germany)"	2024	CircHIPK3/miR-124 affects angiogenesis in early-onset preeclampsia via CPT1A-mediated fatty acid oxidation.		CircHIPK3 	hsa_circ_HIPK3	HIPK3	early-onset preeclampsia 	MONDO:0005081	preeclampsia	down-regulated	RT-qPCR	"In EOPE, circHIPK3 is down-regulated in placental tissues and is mainly localized in the cytoplasm of endothelial cells. The study shows that circHIPK3 acts as a ceRNA for miR-124-3p to maintain CPT1A expression, supporting CPT1A-mediated fatty acid oxidation, endothelial cell proliferation, cell cycle progression, and tube formation. Loss of circHIPK3 impairs endothelial angiogenesis, which may contribute to aberrant angiogenesis in EOPE."	0.7404
38908277	Environment international	2024	Circular RNA circNIPBL regulates TP53-H179R mutations in NNK-induced bronchial epithelial carcinogenesis.	hsa_circ_0001472	circNIPBL 	hsa_circ_NIPBL	NIPBL	NNK-induced bronchial epithelial carcinogenesis 	MONDO:0021117	lung neoplasm	down-regulated	RT-qPCR; RNA-seq	"circNIPBL is a human tumor suppressor-like circRNA downregulated during NNK-induced bronchial epithelial carcinogenesis and in lung cancer cell lines. Loss of circNIPBL promotes proliferation, migration, invasion, tumor formation and TP53-H179R accumulation, while overexpression suppresses malignant phenotypes. Mechanistically, circNIPBL interacts with HSP90alpha to strengthen HSP90alpha-AHR binding in the cytoplasm, thereby limiting AHR nuclear translocation during NNK-induced carcinogenesis."	0.7922
38914746	Endocrine	2024	Hsa_circ_0010023 promotes the development of papillary thyroid carcinoma by sponging miR-1250-5p.	hsa_circ_0010023	hsa_-circ_0010023 	hsa_circ_DHRS3	DHRS3	Papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"hsa_circ_0010023 is up-regulated in PTC tissues and is associated with lymph node metastasis and extrathyroid infiltration. Functional knockdown experiments in K1 cells indicate that it promotes proliferation and inhibits apoptosis. Mechanistically, it may sponge miR-1250-5p and regulate MAPK1, supporting its potential role as a diagnostic biomarker for PTC."	0.8078
38914746	Endocrine	2024	Hsa_circ_0010023 promotes the development of papillary thyroid carcinoma by sponging miR-1250-5p.	hsa_circ_0128482	hsa_-circ_0128482 			Papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"hsa_circ_0128482 is up-regulated in PTC tissues compared with adjacent normal tissues and was evaluated for diagnostic potential by ROC analysis. Unlike hsa_circ_0010023, the study did not report functional experiments or a mechanism for hsa_circ_0128482 and found no significant correlation with clinical features."	0.4187
38917633	Biochemical and biophysical research communications	2024	RNA editing enzyme ADAR2 regulates P-glycoprotein expression in murine breast cancer cells through the circRNA-miRNA pathway.	mmu_circ_0004175	circHif1a	mmu_circ_Hif1a	Hif1a	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"In murine 4T1 breast cancer cells, ADAR2 knockdown increases circHif1a expression. circHif1a acts as a miR-195a-3p sponge, causing increased Abcb1b/P-gp expression and reduced susceptibility to doxorubicin, thereby contributing to chemoresistance."	0.686
38917755	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2024	Identification of a circular RNA isoform of WASHC2A as a prognostic factor for high-risk paediatric B-ALL patients.		circ-WASHC2A 	hsa_circ_WASHC2A	WASHC2A	Pediatric B-cell acute lymphoblastic leukemia 	MONDO:0000872	B-cell childhood acute lymphoblastic leukemia	up-regulated	RT-qPCR; RNA-seq	"circWASHC2A is a WASHC2A-derived circRNA up-regulated in high-risk pediatric B-ALL and validated by RT-qPCR. It may function as a diagnostic and prognostic biomarker, especially for high-risk patient relapse prediction. Functional silencing experiments indicate that it regulates cell cycle distribution, cyclin expression, mitochondrial respiratory activity, and Notch/NFAT-related transcriptomic programs in leukemic B cells."	0.7039
38917755	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2024	Identification of a circular RNA isoform of WASHC2A as a prognostic factor for high-risk paediatric B-ALL patients.		circRAD18 	hsa_circ_RAD18	RAD18	Pediatric B-cell acute lymphoblastic leukemia 	MONDO:0000872	B-cell childhood acute lymphoblastic leukemia	up-regulated	RT-qPCR; RNA-seq	"circRAD18 is significantly overexpressed in pediatric B-ALL patients compared with T-ALL patients and healthy subjects, with RT-qPCR validation in clinical samples. The study supports its potential diagnostic biomarker role, but it did not stratify risk groups and no functional mechanism was investigated."	0.5135
38918127	Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver	2025	Integrated analysis of ncRNA in hepatocellular carcinoma with CTNNB1 mutations reveals miR-205-5p and miR-3940-3p Axes.	hsa_circ_0007824				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0007824 was identified by circRNA sequencing and validated by qPCR as up-regulated in HCC tumors with CTNNB1 mutations. The study did not experimentally define its mechanism or functional role.	0.5129
38918127	Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver	2025	Integrated analysis of ncRNA in hepatocellular carcinoma with CTNNB1 mutations reveals miR-205-5p and miR-3940-3p Axes.	hsa_circ_0008234	circFOXP1	hsa_circ_FOXP1	FOXP1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0008234, also referred to as circFOXP1, was validated by qPCR as up-regulated in HCC tumors with CTNNB1 mutations. This paper did not directly test its functional mechanism in the CTNNB1-mutant HCC context."	0.5129
38918127	Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver	2025	Integrated analysis of ncRNA in hepatocellular carcinoma with CTNNB1 mutations reveals miR-205-5p and miR-3940-3p Axes.	hsa_circ_0085440	circ_0085440			hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RNA-seq	"circ_0085440 was included in a down-up-down CTNNB1 mutation-associated ceRNA axis, GLIS3-209/circ_0085440-miR-205-5p-GHRHR. The study suggests that reduced circ_0085440 is linked with increased miR-205-5p and decreased GHRHR, contributing to inhibition of HCC cell proliferation."	0.6207
38918974	Protein and peptide letters	2024	Circular RNA hsa_circ_0005939 Regulates UHRF1BP1L Expression by Targeting miR-4693-3p to Promote Colorectal Cancer Progression.	hsa_circ_0005939				Colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005939 is up-regulated in colorectal cancer tissues and cells. It promotes CRC malignant phenotypes by enhancing proliferation and cell cycle progression and inhibiting apoptosis. Mechanistically, it mainly functions as a cytoplasmic ceRNA that sponges miR-4693-3p to increase UHRF1BP1L expression, suggesting potential clinical value as a therapeutic target."	0.7534
38923578	International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience	2024	CircNUP98 promotes the malignant behavior of glioma cells through the miR-520f-3p/ELK4 axis.		circNUP98 	hsa_circ_NUP98	NUP98	Glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circNUP98 is upregulated in human glioma cell lines and acts as an oncogenic circRNA. It promotes glioma cell viability, proliferation, invasion, and migration by sponging miR-520f-3p and relieving repression of ELK4. The study proposes circNUP98 as a potential therapeutic target for glioma treatment."	0.7615
38925846	Anticancer research	2024	Clinical Diagnostic Value of circ-ARHGER28 for Breast Cancer and its Effect on MCF 7 Cell Proliferation and Apoptosis.		circ-ARHGER28	hsa_circ_ARHGEF28	ARHGEF28	breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	"circ-ARHGER28 is down-regulated in breast cancer tissues, peripheral blood, and breast cancer cell lines, and shows diagnostic biomarker potential. Functionally, circ-ARHGER28 overexpression suppresses MCF-7 proliferation, colony formation, and migration while inducing G2/M arrest and apoptosis, likely through regulation of apoptosis-related genes/proteins and the PI3K/AKT/mTOR signaling pathway."	0.7899
38936057	International immunopharmacology	2024	Identification of novel biomarker hsa_circ_0003914 for rheumatoid arthritis from plasma exosomes.	hsa_circ_0003914				rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; RNA-seq	"Plasma exosomal hsa_circ_0003914 is up-regulated in RA patients and positively correlates with clinical disease activity. It promotes FLS proliferation, migration, invasion, inflammatory cytokine secretion, and RA progression through activation of the NF-kappaB/p65 signaling pathway, while knockdown ameliorates CIA mouse disease phenotypes. The study proposes hsa_circ_0003914 as a non-invasive biomarker and therapeutic target for RA."	0.678
38936066	Environment international	2024	circADAMTS6 via stabilizing CAMK2A is involved in smoking-induced emphysema through driving M2 macrophage polarization.	hsa_circ_0072688	circ_0072688 	hsa_circ_ADAMTS6	ADAMTS6	 chronic obstructive pulmonary disease	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR; ISH; RNA-seq	"circADAMTS6 is elevated in CSE-treated macrophages and in serum/lung samples from smokers or COPD smokers. It promotes smoking-related emphysema by forming a circADAMTS6/IGF2BP2/CAMK2A RNA-protein ternary complex that stabilizes CAMK2A mRNA, activates CREB, drives M2 macrophage polarization, and causes proteinase/anti-proteinase imbalance and elastin degradation. Its serum elevation negatively correlates with lung function, suggesting diagnostic and therapeutic relevance."	0.8571
38936066	Environment international	2024	circADAMTS6 via stabilizing CAMK2A is involved in smoking-induced emphysema through driving M2 macrophage polarization.			mmu_circ_Adamts6	Adamts6	 chronic obstructive pulmonary disease	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR; ISH; RNA-seq	"circADAMTS6 is elevated in CSE-treated macrophages and in serum/lung samples from smokers or COPD smokers. It promotes smoking-related emphysema by forming a circADAMTS6/IGF2BP2/CAMK2A RNA-protein ternary complex that stabilizes CAMK2A mRNA, activates CREB, drives M2 macrophage polarization, and causes proteinase/anti-proteinase imbalance and elastin degradation. Its serum elevation negatively correlates with lung function, suggesting diagnostic and therapeutic relevance."	0.8571
38940233	Current eye research	2024	"Circ_0000099/miR-223-3p/CTGF Regulates the Growth, Metastasis, and EMT Processes in TGF-beta2-Stimulated Human Lens Epithelial Cells."	hsa_circ_0000099		hsa_circ_AMY2B	AMY2B	posterior capsular opacification 	MONDO:0005129	cataract	up-regulated	RT-qPCR	"circ_0000099 is up-regulated in PCO tissues and TGF-beta2-stimulated SRA01/04 human lens epithelial cells. It promotes TGF-beta2-induced proliferation, migration, invasion, and EMT by sponging miR-223-3p and increasing CTGF expression, suggesting a potential therapeutic target for PCO."	0.7591
38943979	"Comparative biochemistry and physiology. Part D, Genomics & proteomics"	2024	Identification and characterization of circular RNAs in the skin of rainbow trout (Oncorhynchus mykiss) infected with infectious hematopoietic necrosis virus.		novel_circ_002779	omy_circ_HERC3	HERC3	infectious hematopoietic necrosis 	MONDO:0024934	fish disease	up-regulated	RT-qPCR; RNA-seq	"novel_circ_002779 was up-regulated in rainbow trout skin after IHNV infection and was validated by qRT-PCR. It mainly localized in the cytoplasm and was predicted to function as a ceRNA sponge for miR-205-z, regulating TLR8 and promoting antiviral immune responses."	0.5803
38943979	"Comparative biochemistry and physiology. Part D, Genomics & proteomics"	2024	Identification and characterization of circular RNAs in the skin of rainbow trout (Oncorhynchus mykiss) infected with infectious hematopoietic necrosis virus.		novel_circ_004118 			infectious hematopoietic necrosis 	MONDO:0024934	fish disease	dysregulated	RNA-seq	"novel_circ_004118 was identified as a differentially expressed circRNA in rainbow trout skin after IHNV infection through RNA-seq and network analysis. It was predicted to act as a ceRNA sponge for miR-155-y and regulate PIK3R1, potentially contributing to antiviral immune responses and PI3K/Akt-related regulation."	0.31
38944174	Experimental cell research	2024	CircTOP1 targeted regulation of PTBP1 expression promotes the progression of coronary artery calcification.		circTOP1 	hsa_circ_TOP1	TOP1	coronary artery calcification 	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR; RNA-seq	"circTOP1 is up-regulated in blood from CAC patients and in in vitro and in vivo CAC models. It promotes vascular calcification and VSMC osteogenic transdifferentiation by interacting with and upregulating PTBP1; knockdown of circTOP1 attenuates calcification, mineralized nodule formation, and DNA damage. The study proposes circTOP1 as a potential biomarker and therapeutic target for coronary artery calcification."	0.8632
38944259	Cellular signalling	2024	The hsa_circ_0002371/hsa-miR-502-5p/ATG16L1 axis modulates the survival of intracellular Mycobacterium tuberculosis and autophagy in macrophages.	hsa_circ_0002371	circRNA1291 	hsa_circ_CCAR1	CCAR1	active tuberculosis 	MONDO:0100481	active tuberculosis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0002371 is up-regulated in PBMCs from active tuberculosis patients and in H37Rv- or BCG-infected THP-1 macrophages. It promotes intracellular mycobacterial survival by inhibiting autophagy through the hsa_circ_0002371/hsa-miR-502-5p/ATG16L1 regulatory axis, and it has potential diagnostic biomarker value for ATB."	0.8411
38945202	Cancer letters	2024	A novel protein encoded by circFOXP1 enhances ferroptosis and inhibits tumor recurrence in intrahepatic cholangiocarcinoma.	hsa_circ_0001320	circFOXP1 	hsa_circ_FOXP1	FOXP1	intrahepatic cholangiocarcinoma 	MONDO:0003210	intrahepatic cholangiocarcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circFOXP1 is highly expressed in ICC tumors from patients without postoperative recurrence and high expression predicts better prognosis. It suppresses ICC proliferation, invasion, tumor growth, and recurrence by encoding circFOXP1-231aa, which binds OTUD4, inhibits NCOA4 ubiquitination/degradation, and enhances ferroptosis."	0.8814
38945202	Cancer letters	2024	A novel protein encoded by circFOXP1 enhances ferroptosis and inhibits tumor recurrence in intrahepatic cholangiocarcinoma.		circISPD 	hsa_circ_ISPD	ISPD	intrahepatic cholangiocarcinoma 	MONDO:0003210	intrahepatic cholangiocarcinoma	up-regulated	RT-qPCR; RNA-seq	circISPD was identified by circRNA-seq as one of the circRNAs most highly expressed in ICC tumors from patients without postoperative recurrence and was validated by qRT-PCR as significantly higher in non-recurrent tumors. The study did not report a survival association or functional mechanism for circISPD.	0.6428
38945202	Cancer letters	2024	A novel protein encoded by circFOXP1 enhances ferroptosis and inhibits tumor recurrence in intrahepatic cholangiocarcinoma.	hsa_circ_0021516	circGAS2	hsa_circ_GAS2	GAS2	intrahepatic cholangiocarcinoma 	MONDO:0003210	intrahepatic cholangiocarcinoma	up-regulated	RNA-seq	"circGAS2 was identified by circRNA-seq as a candidate circRNA highly expressed in ICC tumors from patients without postoperative recurrence. Its back-splice junction and circularity were validated, but the study did not report a positive qRT-PCR disease-association result, survival association, functional role, or molecular mechanism for circGAS2."	0.5134
38945378	Toxicology in vitro : an international journal published in association with BIBRA	2024	CircPDSS1 (hsa_circ_0017998) silencing induces ferroptosis in non-small-cell lung cancer cells by modulating the miR-137/SLC7A11/GPX4/GCLC axis.	hsa_circ_0017998	CircPDSS1	hsa_circ_PDSS1	PDSS1	non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circPDSS1 is upregulated in NSCLC cell lines and acts as an oncogenic circRNA that supports NSCLC cell viability and colony formation. Its knockdown induces ferroptosis by relieving suppression of miR-137 and downregulating the SLC7A11/GPX4/GCLC axis, suggesting circPDSS1 as a potential therapeutic target for NSCLC."	0.7198
38951152	Naunyn-Schmiedeberg's archives of pharmacology	2024	Mediation of circ_0007142 on miR-128-3p/S100A14 pathway to stimulate the progression of cervical cancer.	hsa_circ_0007142	circ_0007142	hsa_circ_DOCK1	DOCK1	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ_0007142 is up-regulated in cervical cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation, migration, invasion, EMT progression, and xenograft tumor growth by sponging miR-128-3p to increase S100A14 expression. High circ_0007142 expression is associated with shorter overall survival in CC patients, suggesting prognostic and therapeutic relevance."	0.8595
38951469	Molecular neurobiology	2025	EIF4A3-Induced Circ_0059914 Promoted Angiogenesis and EMT of Glioma via the miR-1249/VEGFA Pathway.	hsa_circ_0059914	Circ_0059914	hsa_circ_AHCY	AHCY	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR; Microarray	"circ_0059914 is upregulated in glioma and promotes malignant phenotypes including proliferation, migration, invasion, angiogenesis, EMT, and in vivo tumor growth. Mechanistically, EIF4A3 induces circ_0059914 formation, and circ_0059914 sponges miR-1249 to regulate VEGFA and promote glioma progression."	0.8385
38951482	Molecular biotechnology	2025	CircABHD2 Inhibits Malignant Progression of Endometrial Cancer by Regulating NAD+/NAMPT Metabolism Axis.	hsa_circ_0007099	CircABHD2 	hsa_circ_ABHD2	ABHD2	endometrial cancer 	MONDO:0011962	endometrial cancer	down-regulated	RT-qPCR; RNA-seq	"CircABHD2 (hsa_circ_0007099), derived from ABHD2, is down-regulated in endometrial cancer tissues and cells. It acts as a tumor suppressor by inhibiting proliferation, migration, and invasion, promoting apoptosis, and inducing cell cycle arrest. Mechanistically, circABHD2 reduces NAD + levels and NAMPT protein expression, implicating the NAD + /NAMPT metabolic axis, and it also shows potential diagnostic value for EC."	0.786
38953571	General physiology and biophysics	2024	Differential expression profiles and functional prediction of circular RNAs in lung cancer patients with chronic obstructive pulmonary disease: a pilot study.		hsa-MROH9_0001 	hsa_circ_MROH9	MROH9	lung cancer 	MONDO:0008903	lung cancer	down-regulated	RT-qPCR; Microarray	"hsa-MROH9_0001 was down-regulated in LC patients with COPD and its expression pattern was confirmed by RT-qPCR. The study predicts that it may act through hsa-miR-6789-5p adsorption and may participate in inflammation, immune regulation, and disease progression in LC with COPD."	0.5135
38953571	General physiology and biophysics	2024	Differential expression profiles and functional prediction of circular RNAs in lung cancer patients with chronic obstructive pulmonary disease: a pilot study.		hsa-RP11-35J10_0013 	hsa_circ_RP11-35J10	RP11-35J10	lung cancer 	MONDO:0008903	lung cancer	up-regulated	Microarray	"hsa-RP11-35J10_0013 was up-regulated in the COPD group compared with the control group based on microarray data. It was predicted to sponge hsa-miR-3663-3p, hsa-miR-4640-5p, and hsa-miR-4709-3p and may participate in inflammation and immune-related pathways in LC with COPD."	0.4685
38953571	General physiology and biophysics	2024	Differential expression profiles and functional prediction of circular RNAs in lung cancer patients with chronic obstructive pulmonary disease: a pilot study.		circRNA_21729 	hsa_circ_USP4	USP4	lung cancer 	MONDO:0008903	lung cancer	dysregulated	RT-qPCR; Microarray	"circRNA_21729 was identified through microarray/WGCNA as a candidate circRNA associated with chronic bronchitis pathology in LC patients with COPD, and its expression pattern was validated by RT-qPCR. Although hsa-miR-330-5p was predicted as a sponged miRNA, the authors concluded that circRNA_21279/circRNA_21729 likely does not regulate hsa-miR-330-5p through a ceRNA mechanism in disease progression."	0.5135
38953571	General physiology and biophysics	2024	Differential expression profiles and functional prediction of circular RNAs in lung cancer patients with chronic obstructive pulmonary disease: a pilot study.		hsa-MROH9_0001 	hsa_circ_MROH9	MROH9	chronic obstructive pulmonary disease 	MONDO:0005002	chronic obstructive pulmonary disease	down-regulated	RT-qPCR; Microarray	"hsa-MROH9_0001 was down-regulated in LC patients with COPD and its expression pattern was confirmed by RT-qPCR. The study predicts that it may act through hsa-miR-6789-5p adsorption and may participate in inflammation, immune regulation, and disease progression in LC with COPD."	0.5135
38953571	General physiology and biophysics	2024	Differential expression profiles and functional prediction of circular RNAs in lung cancer patients with chronic obstructive pulmonary disease: a pilot study.		hsa-RP11-35J10_0013 	hsa_circ_RP11-35J10	RP11-35J10	chronic obstructive pulmonary disease 	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	Microarray	"hsa-RP11-35J10_0013 was up-regulated in the COPD group compared with the control group based on microarray data. It was predicted to sponge hsa-miR-3663-3p, hsa-miR-4640-5p, and hsa-miR-4709-3p and may participate in inflammation and immune-related pathways in LC with COPD."	0.4685
38953571	General physiology and biophysics	2024	Differential expression profiles and functional prediction of circular RNAs in lung cancer patients with chronic obstructive pulmonary disease: a pilot study.		circRNA_21729 	hsa_circ_USP4	USP4	chronic obstructive pulmonary disease 	MONDO:0005002	chronic obstructive pulmonary disease	dysregulated	RT-qPCR; Microarray	"circRNA_21729 was identified through microarray/WGCNA as a candidate circRNA associated with chronic bronchitis pathology in LC patients with COPD, and its expression pattern was validated by RT-qPCR. Although hsa-miR-330-5p was predicted as a sponged miRNA, the authors concluded that circRNA_21279/circRNA_21729 likely does not regulate hsa-miR-330-5p through a ceRNA mechanism in disease progression."	0.5135
38958715	Neoplasma	2024	Circular RNA IARS modulates the progression and ferroptosis of osteosarcoma via sponging miR-188-5p from RAB14.	hsa_circ_0006702	circ-IARS 	hsa_circ_IARS	IARS	Osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ-IARS is up-regulated in osteosarcoma tissues and cells and functions as an oncogenic circRNA. It promotes OS proliferation, invasion, and in vivo tumor growth while suppressing ferroptosis through the miR-188-5p/RAB14 regulatory axis. High circ-IARS expression is associated with advanced clinical stage, distant metastasis, and poorer overall survival."	0.7972
38963113	Current gene therapy	2025	Knockdown of hsa_circ_0102231 Impedes the Progression of Liver Cancer through the miR-873-SOX4 Axis.	hsa_circ_0102231		hsa_circ_KIAA0586	KIAA0586	liver cancer 	MONDO:0002691	liver cancer	up-regulated	RT-qPCR	"hsa_circ_0102231 is up-regulated in liver cancer cell lines and promotes liver cancer progression. Its knockdown inhibits proliferation, migration, and xenograft tumor growth by increasing miR-873 and reducing SOX4 expression through the miR-873/SOX4 regulatory axis."	0.627
38963787	Cancer biotherapy & radiopharmaceuticals	2024	Hsa_Circ_002144 Promotes Glycolysis and Immune Escape of Breast Cancer Through miR-326/PKM Axis.		hsa_circ_002144 	hsa_circ_RPPH1	RPPH1	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; ISH	"In this study, hsa_circ_002144 is identified as an upregulated breast cancer circRNA derived from RPPH1. It promotes malignant phenotypes including proliferation, migration, invasion, EMT, tumor growth and metastasis while inhibiting apoptosis. Mechanistically, hsa_circ_002144 sponges miR-326 to elevate PKM expression and promote glycolysis, and exosomal hsa_circ_002144 enters macrophages to induce M2 polarization and immune escape."	0.8175
38963941	Cytokine	2024	Circular RNA circPHF16 enhances IL-17A expression and secretion by sequestering miR-378a-3p to activate the IL6ST axis in Graves' disease.	hsa_circ_0090364	circPHF16	hsa_circ_PHF16	PHF16	Graves' disease 	MONDO:0005364	Graves disease	up-regulated	RT-qPCR	"circPHF16 is up-regulated in PBMCs and serum of Graves' disease patients and in splenic CD4+ T lymphocytes of GD model mice. It promotes IL-17A expression and secretion in Jurkat T cells by acting as a ceRNA that sequesters miR-378a-3p and up-regulates IL6ST, with predicted involvement of the JAK-STAT pathway. The study proposes circPHF16 as a potential diagnostic and therapeutic target for GD."	0.8324
38963941	Cytokine	2024	Circular RNA circPHF16 enhances IL-17A expression and secretion by sequestering miR-378a-3p to activate the IL6ST axis in Graves' disease.	mmu_circ_0001581	circPHF16	mmu_circ_PHF16	PHF16	Graves' disease 	MONDO:0005364	Graves disease	up-regulated	RT-qPCR	"circPHF16 is up-regulated in PBMCs and serum of Graves' disease patients and in splenic CD4+ T lymphocytes of GD model mice. It promotes IL-17A expression and secretion in Jurkat T cells by acting as a ceRNA that sequesters miR-378a-3p and up-regulates IL6ST, with predicted involvement of the JAK-STAT pathway. The study proposes circPHF16 as a potential diagnostic and therapeutic target for GD."	0.8324
38964515	Transplant immunology	2024	"The circ_0003928/miR-31-5p/MAPK6 cascade affects high glucose-induced inflammatory response, fibrosis and oxidative stress in HK-2 cells."	hsa_circ_0003928	circ_0003928	hsa_circ_TAOK1	TAOK1	Diabetic nephropathy 	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"In a high glucose-induced HK-2 cell model of diabetic nephropathy, circ_0003928 is up-regulated and contributes to cell injury. Knockdown of circ_0003928 promotes cell viability and suppresses apoptosis, inflammation, fibrosis and oxidative stress. Mechanistically, circ_0003928 sponges miR-31-5p to regulate MAPK6 and may affect AKT signaling, suggesting a potential therapeutic target for DN."	0.7721
38966002	Current eye research	2024	Circular RNA Circ_0122396 Regulates Human Lens Epithelial Cell Progression by Regulating miR-23a-3p and MMP16 in Age-Related Cataract.	hsa_circ_0122396	Circ_0122396	hsa_circ_MED12L	MED12L	age-related cataract 	MONDO:0004847	senile cataract	down-regulated	RT-qPCR	"Circ_0122396 is down-regulated in ARC anterior lens capsules. In H2O2-stimulated human lens epithelial cells, circ_0122396 overexpression promotes proliferation and suppresses apoptosis and oxidative injury. Mechanistically, circ_0122396 functions as a miR-23a-3p sponge to regulate MMP16, forming a circ_0122396-miR-23a-3p-MMP16 axis with potential biomarker and therapeutic relevance for ARC."	0.8107
38970722	Biochemical genetics	2025	"CircFAM114A2 Suppresses Cell Proliferation, Migration, and Invasion of Colorectal Cancer Through Sponging miR-647 to Upregulate DAB2IP Expression."	hsa_circ_0001546	circFAM114A2	hsa_circ_FAM114A2	FAM114A2	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"circFAM114A2 is downregulated in colorectal cancer tissues and cell lines, and low expression is associated with poorer overall survival. Functionally, circFAM114A2 suppresses CRC cell proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, it acts as a miR-647 sponge to increase DAB2IP expression, forming a circFAM114A2/miR-647/DAB2IP regulatory axis."	0.7793
38975651	Archives of physiology and biochemistry	2024	Hsa_circ_0004776 regulates the retina neovascularization in progression of diabetic retinopathy via hsa-miR-382-5p/BDNF axis.	hsa_circ_0004776		hsa_circ_PMS1	PMS1	diabetic retinopathy 	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR; RNA-seq	"This study identifies hsa_circ_0004776 as an up-regulated circRNA in diabetic retinopathy and high-glucose-treated hRECs. hsa_circ_0004776 promotes retinal microvascular endothelial cell viability, migration and tube formation by binding hsa-miR-382-5p and modulating BDNF-associated PI3K/AKT/mTOR signaling, suggesting therapeutic and clinical relevance in DR."	0.7376
38976139	Cardiovascular toxicology	2024	Circ_0005699 Expedites ox-LDL-Triggered Endothelial Cell Injury via Targeting miR-384/ASPH Axis.	hsa_circ_0005699	Circ_0005699			Atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"circ_0005699 is up-regulated in serum from AS patients and in ox-LDL-induced HUVECs. It promotes endothelial cell injury by sponging miR-384 and increasing ASPH expression, leading to decreased proliferation and angiogenesis and increased apoptosis, inflammation, and oxidative stress. Silencing circ_0005699 may represent a potential therapeutic strategy for AS."	0.7799
38980439	Functional & integrative genomics	2024	Circ-IP6K2 suppresses tumor progression by modulating the miR-1292-5p/CAMK2N1 signal in clear cell renal cell carcinoma.	hsa_circ_0003748	hsa_circRNA_103372 	hsa_circ_IP6K2	IP6K2	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	down-regulated	RT-qPCR; Microarray	"circ-IP6K2 is a human IP6K2-derived circular RNA that is downregulated in ccRCC tissues and cell lines, and lower expression is linked to advanced TNM stage and poorer overall survival. Functionally, circ-IP6K2 acts as a tumor suppressor by inhibiting proliferation, migration, invasion, tumor growth, and lung metastasis. Mechanistically, it sponges miR-1292-5p to regulate CAMK2N1 and suppress the beta-catenin/c-Myc signaling pathway."	0.8814
38980654	Journal of cardiovascular translational research	2024	Circulating circ_0069094 is Correlated with the Present and Endothelial Injury of Acute Coronary Syndrome.	hsa_circ_0069094	circ_0069094 			acute coronary syndrome 	MONDO:0005542	acute coronary syndrome	down-regulated	RT-qPCR; Microarray	"circ_0069094 is down-regulated in ACS patient serum and has potential diagnostic value for ACS. Functionally, increasing circ_0069094 protects against oxidative stress, endothelial injury and cardiac dysfunction in ACS models, and improves H/R-induced HUVEC viability and migration while reducing apoptosis. Mechanistically, circ_0069094 acts through a miR-484-related ceRNA axis."	0.7657
38981227	International immunopharmacology	2024	"circSLTM knockdown attenuates chondrocyte inflammation, apoptosis and ECM degradation in osteoarthritis by regulating the miR-515-5p/VAPB axis."	hsa_circ_0000605	circSLTM	hsa_circ_SLTM	SLTM	osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circSLTM/hsa_circ_0000605 is up-regulated in OA cartilage tissues and LPS-treated human chondrocytes. It promotes OA progression by acting as a ceRNA for miR-515-5p to increase VAPB expression and activate NF-kappaB signaling, leading to inflammation, apoptosis, ECM degradation, and reduced chondrocyte proliferation. Knockdown of circSLTM protects chondrocytes in vitro and alleviates cartilage damage in an ACLT-induced OA mouse model."	0.8571
38982736	Biotechnology and applied biochemistry	2024	CircMYO1C silencing alleviates chondrocytes inflammation and apoptosis through m6A/HMGB1 axis in osteoarthritis.	hsa_circ_0041234	circMYO1C	hsa_circ_MYO1C	MYO1C	osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circMYO1C is upregulated in OA cartilage tissues and IL-1beta-exposed human chondrocytes. It promotes chondrocyte apoptosis and inflammation by targeting the m6A/HMGB1 axis and enhancing HMGB1 mRNA stability, suggesting circMYO1C as a potential therapeutic target for OA."	0.8107
38993483	Toxicology research	2024	Knockdown of circ_0076305 decreases the paclitaxel resistance of non-small cell lung cancer cells by regulating TMPRSS4 via miR-936.	hsa_circ_0076305	circular RNA_0076305 			non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"Circ_0076305 is up-regulated in paclitaxel-resistant NSCLC tissues and cells. It promotes PTX resistance and malignant cellular behaviors by sponging miR-936 to increase TMPRSS4 expression, while its knockdown enhances PTX sensitivity, suppresses proliferation, migration, invasion and glycolysis, and promotes apoptosis."	0.7552
38994624	Anti-cancer agents in medicinal chemistry	2024	"Overexpression of NOP58 Facilitates Proliferation, Migration, Invasion, and Stemness of Non-small Cell Lung Cancer by Stabilizing hsa_circ_0001550."	hsa_circ_0001550				non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0001550 is up-regulated in NSCLC cell lines A549 and PC9. Its knockdown inhibits proliferation, migration, invasion, and stemness, while the RBP NOP58 binds to and stabilizes hsa_circ_0001550 to promote these malignant NSCLC cell phenotypes."	0.6435
39002691	Cancer letters	2024	Therapeutic SHPRH-146aa encoded by circ-SHPRH dynamically upregulates P21 to inhibit CDKs in neuroblastoma.	hsa_circ_0001649	circ-SHPRH 	hsa_circ_SHPRH	SHPRH	neuroblastoma 	MONDO:0005072	neuroblastoma	down-regulated	RT-qPCR; ISH	"Circ-SHPRH is downregulated in neuroblastoma and low expression is associated with worse clinical features and poorer survival. Functionally, circ-SHPRH suppresses NB proliferation, migration, invasion, and tumor growth by encoding SHPRH-146aa, which upregulates P21 and inhibits CDK complex activity to induce cell-cycle arrest. The study also suggests circ-SHPRH as a biomarker and potential gene therapy agent, including in combination with the mTOR inhibitor everolimus."	0.8621
39004325	Cellular signalling	2024	CircATF6 inhibits hepatocellular carcinoma progression by suppressing calreticulin-mediated Wnt/beta-catenin signaling pathway.		circ0003039 	hsa_circ_ATF6	ATF6	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; ISH; Microarray	"circATF6 is downregulated in HCC and functions as a tumor suppressor. It binds CALR and CAPN2 as a scaffold to promote CALR degradation, thereby inactivating CALR-mediated Wnt/beta-catenin signaling and inhibiting HCC cell growth in vitro and in vivo. Clinically, higher circATF6 expression is associated with better survival, suggesting prognostic and therapeutic value."	0.9009
39004326	Cellular signalling	2024	CircPGM5 regulates Foxo3a phosphorylation via MiR-21-5p/MAPK10 axis to inhibit bladder cancer progression.	hsa_circ_0087138	circPGM5	hsa_circ_PGM5	PGM5	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"circPGM5 is a human PGM5-derived circRNA that is down-regulated in bladder cancer tissues and cell lines. It functions as a tumor suppressor by sponging miR-21-5p, increasing MAPK10 expression, reducing Foxo3a phosphorylation, and inhibiting proliferation, migration, invasion, tumor growth, and metastasis."	0.8661
39005285	bioRxiv : the preprint server for biology	2024	circPCMTD1 : A protein-coding circular RNA that regulates DNA damage response in BCR/ABL -positive leukemias.		circPCMTD1	hsa_circ_PCMTD1	PCMTD1	acute leukemias	MONDO:0010643	acute leukemia	up-regulated	RT-qPCR	"circPCMTD1 is a human protein-coding circular RNA implicated in BCR/ABL-positive leukemias, especially advanced CML. It produces a peptide that binds BTR complex proteins and supports BTR complex formation, thereby promoting DNA damage tolerance, DNA replication, cell cycle progression, and leukemic proliferation. Clinically, high circPCMTD1 expression was associated with better survival in CN-AML, while increased abundance in advanced CML and successful gapmer targeting in xenografts support its potential as a therapeutic vulnerability in BCR/ABL1-positive myeloid malignancies."	0.7738
39007896	Autoimmunity	2024	Silencing of CircTRIM25/miR-138-5p/CREB1 axis promotes chondrogenesis in osteoarthritis.	hsa_circ_0044719	circTRIM25 	hsa_circ_TRIM25	TRIM25	osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0044719, termed circTRIM25, is upregulated in OA cartilage tissues and IL-1beta-stimulated chondrocytes. It functions as a cytoplasmic sponge for miR-138-5p to regulate CREB1, promoting ferroptosis, inflammation and OA progression; silencing circTRIM25 promotes chondrogenesis and attenuates DMM-induced OA in vivo."	0.8508
39008951	Gynecologic and obstetric investigation	2025	Circ_0043314 Modulates Proliferation and Apoptosis of Ovarian Granulosa Cells in Polycystic Ovarian Syndrome via the MicroRNA-146b-3p/Apelin 13 Axis.	hsa_circ_0043314	circ_0043314			polycystic ovary syndrome 	MONDO:0008487	polycystic ovary syndrome	up-regulated	RT-qPCR	"In PCOS ovarian tissues, circ_0043314 is up-regulated and is associated with higher BMI among PCOS patients. Functionally, circ_0043314 promotes ovarian granulosa cell proliferation and inhibits apoptosis. Mechanistically, it binds miR-146b-3p and modulates Apelin 13 expression through the circ_0043314/miR-146b-3p/Apelin 13 axis, suggesting potential value as a PCOS biomarker or therapeutic target."	0.6996
39014193	Oncogene	2024	N6-methyladenosine modified circPAK2 promotes lymph node metastasis via targeting IGF2BPs/VEGFA signaling in gastric cancer.	hsa_circ_0003036	circPAK2	hsa_circ_PAK2	PAK2	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circPAK2 is a human PAK2-derived circRNA that is upregulated in gastric cancer tissues and metastatic lymph node tissues. It promotes gastric cancer migration, invasion, EMT, angiogenesis, lymphangiogenesis, and lymph node metastasis through an m6A-dependent YTHDC1-mediated nuclear export mechanism and a cytoplasmic circPAK2/IGF2BPs/VEGFA complex that stabilizes VEGFA mRNA. High circPAK2 expression predicts LN metastasis and poor OS/DFS, supporting its potential use as a prognostic biomarker and therapeutic target."	0.8999
39015057	Journal of biochemical and molecular toxicology	2024	Hsa_circRNA_007630 knockdown delays colon cancer progression by modulation of ferroptosis via miR-506-3p/AURKA axis.		hsa_circRNA_007630 	hsa_circ_MBNL1	MBNL1	colon cancer	MONDO:0021063	malignant colon neoplasm	up-regulated	RNA-seq	"In this study, hsa_circRNA_007630 was upregulated in colon cancer tumor samples and functioned as a miR-506-3p sponge. Knockdown of hsa_circRNA_007630 inhibited HT29 cell proliferation, migration and invasion, and its effects were rescued by miR-506-3p inhibition or AURKA overexpression. The study proposes a hsa_circRNA_007630/miR-506-3p/AURKA regulatory axis that promotes colon cancer progression partly by suppressing ferroptosis."	0.6829
39017680	American journal of physiology. Endocrinology and metabolism	2024	Circulating exosomal circRNA-miRNA-mRNA network in a familial partial lipodystrophy type 3 family with a novel PPARG frameshift mutation c.418dup.	hsa_circ_0001597	circ_0001597 			Familial partial lipodystrophy 3 	MONDO:0020088	familial partial lipodystrophy	up-regulated	RNA-seq	"In plasma exosomes from a FPLD3 family carrying a novel PPARG frameshift mutation, circ_0001597 was increased and was incorporated into a predicted circRNA-miRNA-mRNA network. The study proposes that circ_0001597 sponges miR-671-5p to regulate EGR1 and AGPAT3, genes involved in triglyceride synthesis and lipolysis, thereby potentially contributing to FPLD3-associated metabolic disturbance. Evidence is sequencing- and bioinformatics-based, without RT-qPCR or functional experimental validation for this circRNA."	0.348
39017976	Molecular neurobiology	2025	Exploring the Roles of m6A-Modified circRNAs in Myasthenia Gravis Based on Multi-Omics Analysis.	hsa_circ_0084735				Myasthenia gravis 	MONDO:0009688	myasthenia gravis	down-regulated	RT-qPCR; Microarray	"hsa_circ_0084735 was identified as a candidate m6A-modified circRNA associated with MG through multi-omics integration and random walk with restart. Its m6A-modified level was validated by MeRIP-qPCR as decreased in MG patients, and the study suggests it may participate in MG pathogenesis through a circRNA-miRNA-gene regulatory network involving hsa-miR-183-5p and hsa-miR-29c-3p."	0.5351
39017976	Molecular neurobiology	2025	Exploring the Roles of m6A-Modified circRNAs in Myasthenia Gravis Based on Multi-Omics Analysis.	hsa_circ_0025731				Myasthenia gravis 	MONDO:0009688	myasthenia gravis	down-regulated	RT-qPCR; Microarray	hsa_circ_0025731 was prioritized as a candidate m6A-modified circRNA associated with MG and was validated by MeRIP-qPCR as having decreased m6A methylation in MG patients. The study links it to a circRNA-miRNA-gene regulatory network through hsa-miR-29c-3p and reports positive correlations between its m6A-modified level and type 1/type 2 T-helper cells.	0.5351
39021178	"Endocrine, metabolic & immune disorders drug targets"	2025	METTL3-mediated m6A Modification of hsa_circ_0131922 Attenuates the Progression of Papillary Thyroid Cancer by Regulating the p53 Pathway.	hsa_circ_0131922		hsa_circ_GCLC	GCLC	Papillary Thyroid Cancer 	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0131922 is a human circRNA derived from GCLC and is downregulated in PTC tissues and cell lines. It acts as a tumor suppressor: overexpression inhibits proliferation, migration, invasion, and xenograft tumor growth, while activating the p53/p21 pathway. METTL3 mediates m6A modification of hsa_circ_0131922, and low hsa_circ_0131922 expression is associated with poor prognosis in PTC patients."	0.7855
39024764	Journal of hazardous materials	2024	"The role of circHmbox1(3,4) in ferroptosis-mediated cognitive impairments induced by manganese."		circ1850 	mmu_circ_Hmbox1	Hmbox1	Mn-induced cognitive impairments 	MONDO:0017638	manganese poisoning	down-regulated	RT-qPCR; RNA-seq	"circHmbox1(3,4), also referred to as circ1850, is a mouse Hmbox1-derived circRNA that is down-regulated after manganese exposure in N2a cells and mouse prefrontal cortex. Its overexpression protects against Mn-induced ferroptosis and cognitive impairment by binding GPX4 and reducing GPX4 ubiquitination and degradation. Mn appears to suppress circHmbox1(3,4) biogenesis through reduced E2F1/QKI signaling."	0.8196
39028686	Cardiovascular research	2024	CircARCN1 aggravates atherosclerosis by regulating HuR-mediated USP31 mRNA in macrophages.	hsa_circ_0005589	circARCN1 	hsa_circ_ARCN1	ARCN1	atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR; ISH; RNA-seq	"circARCN1 is upregulated in PBMCs from patients with SA/ACS and in atherosclerotic plaques, especially in monocytes and macrophages. It promotes macrophage inflammation, adhesion, migration, plaque macrophage accumulation, lipid accumulation, and atherosclerotic lesion progression by binding HuR and impairing HuR-mediated USP31 mRNA stabilization, thereby activating NF-kappaB signaling. Clinically, higher circARCN1 levels are associated with increased SA and ACS risk and show potential diagnostic value."	0.8912
39028686	Cardiovascular research	2024	CircARCN1 aggravates atherosclerosis by regulating HuR-mediated USP31 mRNA in macrophages.			mmu_circ_Arcn1	Arcn1	atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR; ISH; RNA-seq	"circARCN1 is upregulated in PBMCs from patients with SA/ACS and in atherosclerotic plaques, especially in monocytes and macrophages. It promotes macrophage inflammation, adhesion, migration, plaque macrophage accumulation, lipid accumulation, and atherosclerotic lesion progression by binding HuR and impairing HuR-mediated USP31 mRNA stabilization, thereby activating NF-kappaB signaling. Clinically, higher circARCN1 levels are associated with increased SA and ACS risk and show potential diagnostic value."	0.8912
39030862	Journal of biochemical and molecular toxicology	2024	"CircCOL5A1 is involved in proliferation, invasion, and inhibition of ferroptosis of colorectal cancer cells via miR-1287-5p/SLC7A11."	hsa_circ_0007482	circCOL5A1 	hsa_circ_COL5A1	COL5A1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circCOL5A1 is up-regulated in colorectal cancer tissues and cells and is associated with advanced clinicopathological features and poor overall survival. Functionally, circCOL5A1 promotes CRC cell proliferation, invasion, and xenograft tumor growth while suppressing ferroptosis. Mechanistically, it acts through the circCOL5A1/miR-1287-5p/SLC7A11 axis."	0.8067
39033888	International journal of biological macromolecules	2024	A novel nanoplatform-based circCSNK1G3 affects CBX7 protein and promotes glioma cell growth.		circCSNK1G3	hsa_circ_CSNK1G3	CSNK1G3	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circCSNK1G3 is upregulated in human glioma tissues and glioma cell lines and acts as an oncogenic circRNA. It promotes glioma cell survival, proliferation, migration, invasion and xenograft tumor growth by stabilizing miR-181d and suppressing the tumor-suppressor CBX7. Knockdown of circCSNK1G3 reduces miR-181d, increases CBX7, inhibits tumor growth and activates apoptosis, supporting circCSNK1G3 as a potential therapeutic target."	0.612
39033937	Gene	2024	Identification and functional analysis of circular RNA expression profiles associated with ammonia exposure in chicken lungs.		circNBAS	gga_circ_NBAS	NBAS	ammonia exposure-induced lung injury 	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR; RNA-seq	circNBAS was up-regulated in chicken lungs after ammonia exposure and validated by RT-qPCR and Sanger sequencing. It was included among key DE circRNAs potentially related to the host immune response under ammonia exposure.	0.6475
39033937	Gene	2024	Identification and functional analysis of circular RNA expression profiles associated with ammonia exposure in chicken lungs.		circMTIF2	gga_circ_MTIF2	MTIF2	ammonia exposure-induced lung injury 	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR; RNA-seq	circMTIF2 was up-regulated in ammonia-exposed chicken lung tissue. It was experimentally validated as a DE circRNA and included in predicted ceRNA networks related to immune response.	0.5971
39033937	Gene	2024	Identification and functional analysis of circular RNA expression profiles associated with ammonia exposure in chicken lungs.		circXPO1	gga_circ_XPO1	XPO1	ammonia exposure-induced lung injury 	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR; RNA-seq	circXPO1 was validated as an up-regulated DE circRNA in ammonia-exposed chicken lungs. The study suggests it may participate in immune response through predicted circRNA-miRNA-mRNA regulation.	0.5971
39033937	Gene	2024	Identification and functional analysis of circular RNA expression profiles associated with ammonia exposure in chicken lungs.		circRAB11A	gga_circ_RAB11A	RAB11A	ammonia exposure-induced lung injury 	MONDO:0015796	acute lung injury	down-regulated	RT-qPCR; RNA-seq	"circRAB11A was significantly down-regulated in ammonia-stimulated chicken lungs and validated by RT-qPCR, Sanger sequencing, and RNase R-based circularity assays. The authors propose that down-regulated circRAB11A may attenuate lung injury through the gga-miR-191b-3p-BRD2 ceRNA axis."	0.5971
39033937	Gene	2024	Identification and functional analysis of circular RNA expression profiles associated with ammonia exposure in chicken lungs.		circARID3B 	gga_circ_ARID3B	ARID3B	ammonia exposure-induced lung injury 	MONDO:0015796	acute lung injury	down-regulated	RT-qPCR; RNA-seq	circARID3B was significantly down-regulated in chicken lungs after ammonia exposure and experimentally validated. The study proposes that it may enhance the immune response through a predicted gga-miR-1696-CKS2 ceRNA regulatory axis.	0.5971
39033937	Gene	2024	Identification and functional analysis of circular RNA expression profiles associated with ammonia exposure in chicken lungs.		circUSP54	gga_circ_USP54	USP54	ammonia exposure-induced lung injury 	MONDO:0015796	acute lung injury	down-regulated	RT-qPCR; RNA-seq	"circUSP54 was down-regulated in ammonia-exposed chicken lungs and experimentally confirmed among nine key DE circRNAs. It may participate in immune-response-related ceRNA regulation, although no specific downstream axis was reported in the provided text."	0.5971
39033937	Gene	2024	Identification and functional analysis of circular RNA expression profiles associated with ammonia exposure in chicken lungs.		circSNX24	gga_circ_SNX24	SNX24	ammonia exposure-induced lung injury 	MONDO:0015796	acute lung injury	down-regulated	RT-qPCR; RNA-seq	circSNX24 was down-regulated in ammonia-exposed chicken lungs and was validated as a circular DE circRNA. It was included in predicted circRNA-miRNA-mRNA networks related to ammonia-induced immune response.	0.5971
39033937	Gene	2024	Identification and functional analysis of circular RNA expression profiles associated with ammonia exposure in chicken lungs.		circPPARA	gga_circ_PPARA	PPARA	ammonia exposure-induced lung injury 	MONDO:0015796	acute lung injury	down-regulated	RT-qPCR; RNA-seq	circPPARA was validated as a down-regulated DE circRNA in chicken lungs exposed to ammonia. It may be involved in non-coding RNA regulatory networks associated with the ammonia-induced immune response.	0.5971
39033937	Gene	2024	Identification and functional analysis of circular RNA expression profiles associated with ammonia exposure in chicken lungs.		circERG	gga_circ_ERG	ERG	ammonia exposure-induced lung injury 	MONDO:0015796	acute lung injury	down-regulated	RT-qPCR; RNA-seq	circERG was down-regulated in ammonia-exposed chicken lung tissue and validated by RT-qPCR and circularity assays. It was proposed as one of the key DE circRNAs potentially contributing to immune response regulation under ammonia exposure.	0.5971
39034802	Zhonghua zhong liu za zhi [Chinese journal of oncology]	2024	[circ_BACH2 affects the malignant biological behavior of papillary thyroid cancer by regulating miR-370-3p].	hsa_circ_0001627	circ_BACH2	hsa_circ_BACH2	BACH2	papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circ_BACH2 is up-regulated in papillary thyroid cancer tissues and cell lines. Functionally, circ_BACH2 promotes malignant biological behaviors of PTC cells, including proliferation, migration, invasion, EMT-related changes and tumor growth, while suppressing apoptosis. Mechanistically, circ_BACH2 acts through the miR-370-3p/GIT1 regulatory axis."	0.7183
39034803	Zhonghua zhong liu za zhi [Chinese journal of oncology]	2024	[Circ_0000263 improves radiosensitivity of Hela cells by inhibiting the activity of telomerase protein through miR-338-3p/TERT].	hsa_circ_0000263	circ_0000263			Gynecologic neoplasms	MONDO:0021148	female reproductive system neoplasm	up-regulated	RT-qPCR	"This study found that circ_0000263 is up-regulated in HeLa cells and after irradiation. circ_0000263 acts through the miR-338-3p/TERT axis to promote proliferation, telomerase activity and radioresistance while suppressing apoptosis; knockdown of circ_0000263 increases radiosensitivity."	0.6578
39038387	"Pathology, research and practice"	2024	"Circ_0000395 promotes cell growth, metastasis and oxaliplatin resistance by regulating miR-153-5p/MYO6 in colorectal cancer."	hsa_circ_0000395	Circ_0000395 	hsa_circ_SLC38A1	SLC38A1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0000395 is up-regulated in colorectal cancer tissues and cells, and high expression is associated with poorer patient survival. Functionally, it promotes CRC cell growth, migration, invasion, tumor growth, metastasis and oxaliplatin resistance while suppressing apoptosis. Mechanistically, circ_0000395 acts as a miR-153-5p sponge to regulate MYO6, contributing to CRC progression and chemoresistance."	0.8443
39042393	Journal of physiology and pharmacology : an official journal of the Polish Physiological Society	2024	Circular E3 ubiquitin-protein ligase improves renal function and alleviates inflammation and renal injury in chronic glomerulonephritis rats via the microRNA-146a-5p / tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma axis.		Circular E3 ubiquitin-protein ligase 	rno_circ_ITCH	ITCH	chronic glomerulonephritis 	MONDO:0002462	glomerulonephritis	down-regulated	RT-qPCR	"circ-ITCH is downregulated in C-BSA-induced CGN rats. Its overexpression improves renal function and reduces inflammation, fibrosis marker expression, IgG deposition, and renal pathological injury, acting through a miR-146a-5p/YWHAG ceRNA axis."	0.5627
39049786	Journal of oral rehabilitation	2024	Non-coding RNA alterations in occlusal disharmony-induced anxiety-like behaviour.		circRNA10039	mmu_circ_Dgki	Dgki	occlusal disharmony-induced anxiety-like behaviour 	MONDO:0011918	anxiety	up-regulated	RT-qPCR; RNA-seq	"circRNA10039 is up-regulated in hippocampal tissues of OD-induced anxiety-like mice. The study selected it as the main circRNA target and proposed that it may interact with PTBP1, affecting mRNA biogenesis and spliceosome-related processes involved in anxiety-like behaviours."	0.4474
39049786	Journal of oral rehabilitation	2024	Non-coding RNA alterations in occlusal disharmony-induced anxiety-like behaviour.		circRNA00211 			occlusal disharmony-induced anxiety-like behaviour 	MONDO:0011919	"autoimmune disease, susceptibility to, 1"	up-regulated	RT-qPCR; RNA-seq	circRNA00211 is up-regulated in hippocampal tissues from OD-induced anxiety-like mice and was validated by qRT-PCR. The article did not report a specific interaction partner or mechanistic function for this circRNA.	0.3213
39049786	Journal of oral rehabilitation	2024	Non-coding RNA alterations in occlusal disharmony-induced anxiety-like behaviour.		circRNA03499	mmu_circ_Grin2b	Grin2b	occlusal disharmony-induced anxiety-like behaviour 	MONDO:0011920	autosomal dominant nonsyndromic hearing loss 48	down-regulated	RT-qPCR; RNA-seq	"circRNA03499 is down-regulated in hippocampal tissues of OD-induced anxiety-like mice and was validated by qRT-PCR. Bioinformatic analysis predicted that circRNA03499 interacts with several RNA-binding proteins, but the article did not experimentally validate a direct interaction or downstream pathway for this circRNA."	0.3684
39049786	Journal of oral rehabilitation	2024	Non-coding RNA alterations in occlusal disharmony-induced anxiety-like behaviour.		circRNA02385			occlusal disharmony-induced anxiety-like behaviour 	MONDO:0011921	"aural atresia, congenital"	down-regulated	RT-qPCR; RNA-seq	circRNA02385 is down-regulated in hippocampal tissues from OD-induced anxiety-like mice and was validated by qRT-PCR. The article did not report a specific interaction partner or mechanistic function for this circRNA.	0.3213
39049786	Journal of oral rehabilitation	2024	Non-coding RNA alterations in occlusal disharmony-induced anxiety-like behaviour.		circRNA03693	mmu_circ_Pak1	Pak1	occlusal disharmony-induced anxiety-like behaviour 	MONDO:0011922	nonimmune chronic idiopathic neutropenia of adults	down-regulated	RT-qPCR; RNA-seq	"circRNA03693 is down-regulated in hippocampal tissues of OD-induced anxiety-like mice and was validated by qRT-PCR. Bioinformatic analysis predicted that circRNA03693 interacts with several RNA-binding proteins, but the article did not experimentally validate a direct interaction or downstream pathway for this circRNA."	0.3684
39054713	Discovery medicine	2024	The Role of Intra-Articular Delivery of BM-MSCs-Derived Exosomes in Improving Osteoarthritis: Implication of circYAP1/miRNA-21/TLR7 Axis.		circYAP1 	rno_circ_YAP1		osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR	"In this rat osteoarthritis study, circYAP1 was significantly downregulated in OA articular tissue. BM-MSC-derived exosome treatment restored circYAP1 expression and was associated with suppression of miRNA-21 and TLR7, reduced inflammatory and oxidative injury, and improved cartilage-related outcomes. The proposed mechanism is modulation of the circYAP1/miRNA-21/TLR7 axis through miRNA-21 sequestration by circYAP1."	0.3957
39069227	Biochimica et biophysica acta. Molecular cell research	2024	CircSlc17a5 controlled by VLDLR/QKI pathway regulated the choroidal angiogenesis.		circSlc17a5	mmu_circ_Slc17a5	Slc17a5	ocular neovascularization 	MONDO:0005328	eye disorder	dysregulated	RT-qPCR; RNA-seq	"This study identifies mouse circSlc17a5 as a VLDLR/QKI-regulated circRNA involved in ocular and choroidal neovascularization. circSlc17a5 is generated from exons 6 to 8 of Slc17a5, is more stable than linear Slc17a5 RNA, and functionally inhibits choroidal sprouting/angiogenesis in ex vivo and animal-model contexts."	0.6596
39082269	Cardiovascular research	2024	CircCHSY1 protects hearts against ischaemia/reperfusion injury by enhancing heme oxygenase 1 expression via miR-24-3p.		circCHSY1 	hsa_circ_CHSY1	chsy1	myocardial ischaemia/reperfusion injury	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR; RNA-seq	"circCHSY1 is up-regulated in myocardial I/R injury and OGD/R-injured cardiomyocytes across mouse, rat, and human cardiomyocyte models. Its overexpression protects hearts and cardiomyocytes by binding miR-24-3p, enhancing HO1 protein expression, preserving mitochondrial homoeostasis, and reducing I/R or OGD/R injury."	0.8519
39082269	Cardiovascular research	2024	CircCHSY1 protects hearts against ischaemia/reperfusion injury by enhancing heme oxygenase 1 expression via miR-24-3p.		circCHSY1 	mmu_circ_chsy1	chsy1	myocardial ischaemia/reperfusion injury	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR; RNA-seq	"circCHSY1 is up-regulated in myocardial I/R injury and OGD/R-injured cardiomyocytes across mouse, rat, and human cardiomyocyte models. Its overexpression protects hearts and cardiomyocytes by binding miR-24-3p, enhancing HO1 protein expression, preserving mitochondrial homoeostasis, and reducing I/R or OGD/R injury."	0.8519
39082269	Cardiovascular research	2024	CircCHSY1 protects hearts against ischaemia/reperfusion injury by enhancing heme oxygenase 1 expression via miR-24-3p.		circCHSY1 	 rno_circ_chsy1	chsy1	myocardial ischaemia/reperfusion injury	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR; RNA-seq	"circCHSY1 is up-regulated in myocardial I/R injury and OGD/R-injured cardiomyocytes across mouse, rat, and human cardiomyocyte models. Its overexpression protects hearts and cardiomyocytes by binding miR-24-3p, enhancing HO1 protein expression, preserving mitochondrial homoeostasis, and reducing I/R or OGD/R injury."	0.8519
39084281	Archives of biochemistry and biophysics	2024	Circ_19038 and lnc-AK016022 synergistically regulate Sirt1 to promote remyelination and alleviate white matter injury in preterm mice.		Circ_19038 			preterm white matter injury 	MONDO:0012511	preterm premature rupture of the membranes	down-regulated	RT-qPCR; ISH	"circ_19038 is down-regulated in the brain tissues of LPS-induced preterm mice with white matter injury. Its overexpression alleviates white matter structural damage, neuroinflammation, and neurological dysfunction, and it acts synergistically with lnc-AK016022. Mechanistically, circ_19038 increases Sirt1 expression by sponging miR-1b-5p, while YTHDF2-mediated m6A-dependent degradation contributes to its downregulation."	0.7507
39097891	"Cellular and molecular biology (Noisy-le-Grand, France)"	2024	Circ_0006220 (circ-TADA2A) accelerates prostate cancer cell malignant behaviors through miR-520f-3p/CDCA7 axis.	hsa_circ_0006220	Circ_0006220 	hsa_circ_TADA2A	TADA2A	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circ-0006220/hsa_circ_0006220 is up-regulated in prostate cancer tissues and cell lines, and high expression is associated with poor survival and lymph-node metastasis. Functionally, it promotes PCa cell proliferation, migration, invasion, EMT, tumor growth and metastasis by sponging miR-520f-3p to increase CDCA7 expression."	0.8069
39098231	International immunopharmacology	2024	CircGNAO1 suppresses hepatocellular carcinoma progression and metastasis via sponging miR-182-5p and regulating FOXO1 expression.	hsa_circ_0105619	circGNAO1	hsa_circ_GNAO1	GNAO1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; ISH; RNA-seq	"circGNAO1/hsa_circ_0105619 is a human GNAO1-derived circRNA that is downregulated in HCC tissues and cells. It suppresses HCC proliferation, migration, invasion, EMT, tumor growth and metastasis by sponging miR-182-5p and regulating FOXO1 within the circGNAO1/miR-182-5p/FOXO1 axis. Clinically, low circGNAO1 expression is associated with poorer overall survival, tumor size and lymph node metastasis, suggesting therapeutic relevance in HCC."	0.8792
39098513	Gene	2024	Circular RNA hsa_circ_0001610 promotes prostate cancer progression by sponging miR-1324 and upregulating PTK6.	hsa_circ_0001610		hsa_circ_TNFRSF21	TNFRSF21	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001610 is up-regulated in prostate cancer, especially CRPC tissues and cell lines. It promotes PCa proliferation, migration, in vivo tumor growth, and enzalutamide resistance by sponging miR-1324 and upregulating PTK6. The study suggests hsa_circ_0001610 may serve as a therapeutic target and biomarker for advanced PCa."	0.871
39098731	Biochemical pharmacology	2024	Circ_0002722-induced regulation of YAP promotes platinum resistance in oral squamous cell carcinoma: Implications for verteporfin therapy.	hsa_circ_0002722	circ_0002722 			oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0002722/circ_0002722 is up-regulated in platinum-resistant OSCC tissues and cells. It directly binds miR-1305 and regulates YAP expression, thereby promoting YAP-mediated platinum resistance and reducing platinum sensitivity. The study proposes circ_0002722 as a potential therapeutic target and diagnostic biomarker for OSCC platinum resistance."	0.7819
39098847	Oncogene	2024	"CircVPS8 promotes the malignant phenotype and inhibits ferroptosis of glioma stem cells by acting as a scaffold for MKRN1, SOX15 and HNF4A."	hsa_circ_0068367	circVPS8	hsa_circ_VPS8	VPS8	glioblastoma 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; Microarray	"CircVPS8 is an up-regulated human circRNA derived from VPS8 in glioblastoma/glioma. It promotes GSC proliferation, viability, sphere formation, stemness and intracranial tumor growth, while inhibiting ferroptosis. Mechanistically, circVPS8 scaffolds MKRN1 and SOX15 to enhance SOX15 ubiquitinated degradation and competitively reduces MKRN1-mediated HNF4A ubiquitination, increasing HNF4A expression and jointly suppressing ferroptosis; clinically, high circVPS8 expression is associated with higher glioma grade and poorer survival."	0.887
39102088	Cell biochemistry and biophysics	2025	Curcumin Inhibits the Development of Pancreatic Cancer by Targeting the circ_0079440/miR-522-3p/EIF4A1 Pathway.	hsa_circ_0079440	circ_0079440	hsa_circ_PHF14	PHF14	Pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"circ_0079440 is up-regulated in pancreatic cancer tissues and cell lines and acts as an oncogenic circRNA. It promotes proliferation, migration, invasion, EMT, tumor growth, and metastasis through a cytoplasmic ceRNA mechanism involving miR-522-3p and EIF4A1. Curcumin suppresses pancreatic cancer progression by downregulating circ_0079440 and thereby inhibiting the circ_0079440/miR-522-3p/EIF4A1 pathway."	0.8689
39110291	Neurochemical research	2024	Circ_0001361/miR-490-5p/IGF2 Axis Regulates the Viability and Apoptosis of Neuroblastoma Cells.	hsa_circ_0001361	circ_FNDC3B 	hsa_circ_FNDC3B	FNDC3B	neuroblastoma 	MONDO:0005072	neuroblastoma	up-regulated	RT-qPCR	"In neuroblastoma, circ_0001361 is up-regulated in tumor tissues and NB cell lines. The study supports an oncogenic role in which circ_0001361 sponges miR-490-5p to regulate IGF2 and activate PI3K/AKT signaling, thereby promoting cell viability/proliferation and inhibiting apoptosis. Knockdown of circ_0001361 suppresses NB cell viability and promotes apoptosis, suggesting potential therapeutic relevance."	0.6996
39113852	American journal of cancer research	2024	Functional analysis of circSNYJ1/miR-142-5p/CCND1 regulatory axis in non-small cell lung cancer.		circSNYJ1 	hsa_circ_SYNJ1	SYNJ1	Non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"circSYNJ1/circSNYJ1 is up-regulated in NSCLC tissues and cell lines and high expression is associated with poor prognosis. It promotes NSCLC proliferation, colony formation, migration, tumorigenicity and metastasis while suppressing apoptosis, mainly through a ceRNA mechanism in which it sponges miR-142-5p to regulate CCND1."	0.8571
39121974	Cellular signalling	2024	CircATXN7 regulates the proliferation and invasion of esophageal cancer cells through miR-4319/NLRC5.	hsa_circ_0066436	circATXN7	hsa_circ_ATXN7	ATXN7	esophageal cancer 	MONDO:0007576	esophageal cancer	up-regulated	RT-qPCR	"circATXN7 is up-regulated in esophageal cancer tissues and cell lines and mainly localizes in the cytoplasm. It promotes EC cell proliferation, invasion, migration, and xenograft tumor growth by acting as a ceRNA for miR-4319 and thereby increasing NLRC5 expression. Knockdown of circATXN7 suppresses EC growth in vivo and supports circATXN7 as a potential therapeutic target."	0.7884
39126511	Molecular biology reports	2024	CircRNA hsa_circ_0003528/miR-215 is considered a potential target for predictive prognosis and therapy for triple-negative breast cancer.	hsa_circ_0003528	circSEC24A	hsa_circ_SEC24A	SEC24A	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0003528/circSEC24A is upregulated in breast cancer, particularly TNBC, and high expression is associated with adverse clinicopathological features and poor overall survival. Functionally, hsa_circ_0003528 promotes TNBC cell proliferation, migration, and invasion, at least partly by binding/regulating miR-215. The study suggests hsa_circ_0003528 as a prognostic biomarker and potential therapeutic target for TNBC."	0.7513
39126580	Cardiovascular toxicology	2024	Hsa_circ_0007765 Promotes Platelet-Derived Growth Factor-BB-Induced Proliferation and Migration of Human Aortic Vascular Smooth Muscle Cells in Atherosclerosis.	hsa_circ_0007765	hsa_circRNA_102353 			Atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR; Microarray	"circ_0007765 is up-regulated in PDGF-BB-induced HA-VSMCs, an in vitro atherosclerosis-related VSMC phenotype model. It promotes HA-VSMC proliferation, invasion and migration by sponging miR-654-3p, increasing FRS2, and activating Akt/mTOR signaling, suggesting circ_0007765 as a potential therapeutic target for AS."	0.7918
39126922	Phytomedicine : international journal of phytotherapy and phytopharmacology	2024	Bu-Shen-Ning-Xin decoction ameliorates premature ovarian insufficiency by suppressing oxidative stress through rno_circRNA_012284/rno_miR-760-3p/HBEGF pathway.		rno_circRNA_012284 			premature ovarian insufficiency 	MONDO:0005387	primary ovarian failure	up-regulated	RT-qPCR	"This study identifies rno_circRNA_012284 as an oxidative stress-related circRNA up-regulated by BSNXD administration in POI rat ovarian tissues/OGCs. rno_circRNA_012284 functions as a sponge for rno_miR-760-3p to increase HBEGF expression, thereby reducing excessive ROS generation and contributing to the amelioration of POI."	0.6908
39133108	DNA and cell biology	2024	EIF4A3-Induced Upregulation of hsa_circ_0049396 Attenuates the Tumorigenesis of Nasopharyngeal Carcinoma by Regulating the Hippo-YAP Pathway.	hsa_circ_0049396		hsa_circ_LDLR	LDLR	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	down-regulated	RT-qPCR	"hsa_circ_0049396 is downregulated in nasopharyngeal carcinoma tissues and cells, and low expression is associated with poor prognosis. EIF4A3 enhances hsa_circ_0049396 expression by binding its flanking regions, while hsa_circ_0049396 overexpression suppresses NPC proliferation, migration, invasion, and xenograft tumor growth through inhibition of the Hippo-YAP pathway. The study suggests hsa_circ_0049396 as a potential diagnostic biomarker or drug target for NPC."	0.7661
39134922	"Reproductive sciences (Thousand Oaks, Calif.)"	2024	hsa_circ_0088196 Predicts Adverse Pregnancy Outcomes in Preeclampsia Patients and Contributes to Endothelial Cell Injury Via Modulating the miR-145-5p/FLT1 Axis.	hsa_circ_0088196				gestational hypertension	MONDO:0024664	"hypertension, pregnancy-induced"	down-regulated	RT-qPCR	"This study identifies hsa_circ_0088196 as a down-regulated serum circRNA associated with gestational hypertension and PE, with reduced levels predicting PE risk, severe PE, and adverse pregnancy outcomes. Functionally, hsa_circ_0088196 overexpression protects HUVECs from H/R-induced endothelial injury by modulating the miR-145-5p/FLT1 axis."	0.7202
39134922	"Reproductive sciences (Thousand Oaks, Calif.)"	2024	hsa_circ_0088196 Predicts Adverse Pregnancy Outcomes in Preeclampsia Patients and Contributes to Endothelial Cell Injury Via Modulating the miR-145-5p/FLT1 Axis.	hsa_circ_0088196				preeclampsia 	MONDO:0005081	preeclampsia	down-regulated	RT-qPCR	"This study identifies hsa_circ_0088196 as a down-regulated serum circRNA associated with gestational hypertension and PE, with reduced levels predicting PE risk, severe PE, and adverse pregnancy outcomes. Functionally, hsa_circ_0088196 overexpression protects HUVECs from H/R-induced endothelial injury by modulating the miR-145-5p/FLT1 axis."	0.7202
39137856	International journal of biological macromolecules	2024	Exploring the role of circ-0091579/miR-1225-5p and circ-HIPK3/miR-338-3p axes in the pathogenesis of postmenopausal osteoporosis.		circ-0091579	hsa_circ_GPC3	GPC3	postmenopausal osteoporosis 	MONDO:0008159	postmenopausal osteoporosis	up-regulated	RT-qPCR	"circ-0091579 was upregulated in PBMCs from postmenopausal women with osteopenia and osteoporosis and increased with disease severity. The study suggests that circ-0091579 targets miR-1225-5p to regulate the Keap1-Nrf2 and NF-kappaB/inflammatory cytokine network, contributing to oxidative stress, bone homeostasis imbalance, and osteoporosis progression; it also showed diagnostic and progression-tracking biomarker potential."	0.6032
39137856	International journal of biological macromolecules	2024	Exploring the role of circ-0091579/miR-1225-5p and circ-HIPK3/miR-338-3p axes in the pathogenesis of postmenopausal osteoporosis.		circ-HIPK3 	hsa_circ_HIPK3	HIPK3	postmenopausal osteoporosis 	MONDO:0008159	postmenopausal osteoporosis	down-regulated	RT-qPCR	"circ-HIPK3 was downregulated in PBMCs from postmenopausal women with osteopenia and osteoporosis, with lower expression associated with greater disease severity. The study suggests that reduced circ-HIPK3 permits miR-338-3p upregulation, leading to MAFB inhibition and bone homeostasis imbalance; circ-HIPK3 also showed utility as a diagnostic and progression-tracking biomarker."	0.6032
39139001	Clinical and experimental pharmacology & physiology	2024	Cancer-associated fibroblast-derived circFARP1 modulates non-small cell lung cancer invasion and metastasis through the circFARP1/miR-338-3p/SOX4 axis.		circFARP1	hsa_circ_FARP1	FARP1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circFARP1 is up-regulated in cancer-associated fibroblasts from NSCLC and promotes CAF migration/invasion as well as A549 proliferation, migration, invasion and tumor growth. Mechanistically, circFARP1 functions as a miR-338-3p sponge to relieve inhibition of SOX4, forming a circFARP1/miR-338-3p/SOX4 axis that supports NSCLC progression and may represent a therapeutic target."	0.7932
39141177	Applied biochemistry and biotechnology	2025	"Circ_0003314 Combines with the miR-26b-5p/IL1RAP Axis to Inhibit HTR-8/SVneo Cell Proliferation, Migration, Invasion and Tube Formation and Promote Apoptosis."	hsa_circ_0003314	circ_0003314	hsa_circ_PCNXL2	PCNXL2	Preeclampsia 	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR	"In this study, circ_0003314 was upregulated in placental tissues from PE patients. Functionally, circ_0003314 overexpression suppressed HTR-8/SVneo trophoblast proliferation, migration, invasion and angiogenic capacity while promoting apoptosis. Mechanistically, circ_0003314 acted as a miR-26b-5p sponge to increase IL1RAP expression, forming a circ_0003314/miR-26b-5p/IL1RAP axis implicated in PE-related trophoblast dysfunction."	0.8122
39151890	Annals of hepatology	2024	CircROBO1 knockdown improves the radiosensitivity of hepatocellular carcinoma by regulating RAD21.	hsa_circ_0066568	circ_0066568 	hsa_circ_ROBO1	ROBO1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"CircROBO1 is up-regulated in HCC tissues, HCC cells, and especially IR-resistant HCC tumor tissues. It promotes HCC radioresistance by acting as a miR-136-5p sponge to up-regulate RAD21, thereby enhancing proliferation and suppressing apoptosis; knockdown of circROBO1 improves radiosensitivity in vitro and in a Huh7 xenograft model. Clinically, high circROBO1 expression is associated with poorer overall survival and aggressive clinicopathologic features."	0.798
39153585	Cellular signalling	2024	METTL3 -mediated m6A modification of circ_0000620 regulates cisplatin sensitivity and apoptosis in lung adenocarcinoma via the MiR-216b-5p/KRAS axis.	hsa_circ_0000620	circ_0000620	hsa_circ_AAGAB	AAGAB	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"circ_0000620 is upregulated in LUAD tissues and cell lines and functions as an oncogenic circRNA that promotes proliferation, migration and cisplatin resistance while inhibiting apoptosis. Mechanistically, METTL3-mediated m6A modification increases circ_0000620 stability, and circ_0000620 sponges miR-216b-5p to regulate KRAS signaling, thereby modulating LUAD cell apoptosis and cisplatin sensitivity."	0.8496
39154531	International immunopharmacology	2024	T cell-related circRNA pairs to predict prognosis of patients with esophageal squamous cell carcinoma.			hsa_circ_NLK	NLK	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circNLK(5,6,7).1/circNLK.1 was identified as a prognosis-related circRNA in ESCC. Higher expression was associated with shorter overall survival, and qRT-PCR showed increased expression in ESCC cell lines. Bioinformatic analysis predicted that circNLK.1 may encode a 98-amino-acid protein with potential relevance to ESCC tumorigenesis and development."	0.5047
39154531	International immunopharmacology	2024	T cell-related circRNA pairs to predict prognosis of patients with esophageal squamous cell carcinoma.			hsa_circ_RC3H1	RC3H1	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	dysregulated	RT-qPCR; RNA-seq	"circRC3H1(2).1 was identified as a prognosis-related circRNA in ESCC. Higher expression was associated with shorter overall survival, while expression analyses showed lower levels in ESCC cancer and lymph node tissues than in normal tissues and lower levels in platelets from ESCC patients than in healthy controls, with mixed changes in ESCC cell lines. No specific downstream molecular mechanism was experimentally established."	0.5047
39160285	Functional & integrative genomics	2024	"Regulatory axis of circular RNA DTNB, microRNA-485-5p, and myeloid cell leukemia 1 attenuates inflammation and apoptosis in caerulein-treated AR42J cells."	mmu_circ_0003940	circular RNA DTNB 	mmu_circ_DTNB	DTNB	acute pancreatitis 	MONDO:0006515	acute pancreatitis	down-regulated	RT-qPCR	"circDTNB is down-regulated in the caerulein-induced AR42J cell model of acute pancreatitis. Functionally, circDTNB attenuates cytotoxicity, inflammatory cytokine release, apoptosis, and pancreatic enzyme release by acting through the miR-485-5p/MCL1 regulatory axis, suggesting a protective role and potential therapeutic relevance in AP."	0.6207
39172343	Applied biochemistry and biotechnology	2025	Circ_0006174 Upregulates IGF1R to Enhance Radioresistance and Tumorigenesis in Colorectal Cancer via miR-940 Suppression.	hsa_circ_0006174	circ_0006174	hsa_circ_RAD23B		Colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"Circ_0006174 is up-regulated in colorectal cancer tissues and cells and is associated with tumor TNM stage. Functionally, it promotes CRC tumorigenesis and radioresistance by enhancing proliferation, migration and invasion while suppressing apoptosis. Mechanistically, circ_0006174 sponges miR-940 to increase IGF1R expression, forming a circ_0006174/miR-940/IGF1R regulatory axis."	0.7552
39179754	Molecular and cellular biochemistry	2025	CircXPO6 promotes breast cancer progression through competitively inhibiting the ubiquitination degradation of c-Myc.	hsa_circ_0038773	circXPO6	hsa_circ_XPO6	XPO6	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"CircXPO6 is up-regulated in TNBC tissues and cells and mainly localized in the cytoplasm. It promotes TNBC proliferation, migration, tumor growth and glycolytic metabolism by binding c-Myc and blocking SPOP-mediated c-Myc ubiquitination and degradation. Clinically, high circXPO6 expression is associated with malignant clinicopathological features and poorer prognosis."	0.8792
39180619	International ophthalmology	2024	EIF4A3-induced hsa_circ_0078136 inhibits the tumorigenesis of retinoblastoma via IL-17 signaling pathway.	hsa_circ_0078136	hsa_ circ_0078136 	hsa_circ_SHPRH	SHPRH	retinoblastoma 	MONDO:0008380	retinoblastoma	down-regulated	RT-qPCR	"hsa_circ_0078136 is down-regulated in retinoblastoma tissues and cell lines and acts as a tumor suppressor. Its overexpression inhibits RB cell proliferation, migration, invasion, and xenograft tumor growth while promoting apoptosis, partly through suppression of IL-17 signaling. EIF4A3 negatively regulates hsa_circ_0078136 formation by binding flanking sequences in SHPRH pre-mRNA."	0.7404
39182401	Mutation research	2024	CircRNA ATF6 suppresses bladder cancer cell proliferation and migration via miR-146a-5p/FLNA axis.	hsa_circ_0007360	circRNA ATF6 	hsa_circ_ATF6	ATF6	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; Microarray	"CircRNA ATF6 is down-regulated in bladder cancer tissues and cell lines and is associated with lymphatic metastasis and invasion depth. Functionally, circRNA ATF6 suppresses BCa cell proliferation, migration and invasion in vitro and reduces xenograft tumor growth in vivo. Mechanistically, it sponges miR-146a-5p to regulate FLNA expression, forming a circRNA ATF6/miR-146a-5p/FLNA axis with potential diagnostic and therapeutic relevance."	0.8351
39182549	European journal of pharmacology	2024	Dihydroartemisinin enhances the radiosensitivity of breast cancer by targeting ferroptosis signaling pathway through hsa_circ_0001610.	hsa_circ_0001610	hsa_-circ_0001610 	hsa_circ_TNFRSF21	TNFRSF21	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"In this study, hsa_circ_0001610 is upregulated in irradiated breast cancer cells and functions as a radioresistance-associated circRNA. It acts as a miR-139-5p sponge to increase SLC7A11 expression and suppress ferroptosis, while DHA downregulates hsa_circ_0001610 to enhance ferroptosis and radiosensitivity."	0.8279
39187041	European journal of pharmacology	2024	Endonuclear Circ-calm4 regulates ferroptosis via a circR-Loop of the COMP gene in pulmonary artery smooth muscle cells.		Circ-calmodulin 4 	mmu_circ_calm4	calmodulin 4	pulmonary hypertension 	MONDO:0005149	pulmonary hypertension	up-regulated	RT-qPCR	"circ-calm4 is up-regulated in hypoxic lung tissues/PASMCs in pulmonary hypertension models. Endonuclear circ-calm4 promotes hypoxia-induced ferroptosis by forming circR-loops at the COMP promoter, repressing COMP expression and altering ferroptosis markers including TFR1, NOX2, GPX4, MDA, and ferrous iron. Silencing circ-calm4 alleviates ferroptosis-related changes and improves hypoxia-induced pulmonary vascular remodeling in vivo."	0.6157
39191355	Gene	2024	METTL3 mediates m6A modification of hsa_circ_0072380 to regulate the progression of gestational diabetes mellitus.	hsa_circ_0000994	hsa_-circ_0000994			gestational diabetes mellitus 	MONDO:0005406	gestational diabetes	down-regulated	RT-qPCR	"hsa_circ_0000994 was identified among differentially m6A-modified circRNAs and was significantly down-regulated in placental tissues from GDM patients. The study validated its circular structure and expression change, but did not perform functional or mechanistic experiments specifically for this circRNA."	0.6304
39191355	Gene	2024	METTL3 mediates m6A modification of hsa_circ_0072380 to regulate the progression of gestational diabetes mellitus.	hsa_circ_0058733	hsa_-circ_0058733			gestational diabetes mellitus 	MONDO:0005406	gestational diabetes	down-regulated	RT-qPCR	"hsa_circ_0058733 was identified among differentially m6A-modified circRNAs and was significantly down-regulated in placental tissues from GDM patients. The study validated its circular structure and expression change, but did not perform functional or mechanistic experiments specifically for this circRNA."	0.6304
39191355	Gene	2024	METTL3 mediates m6A modification of hsa_circ_0072380 to regulate the progression of gestational diabetes mellitus.	hsa_circ_0072380	hsa_-circ_0072380			gestational diabetes mellitus 	MONDO:0005406	gestational diabetes	down-regulated	RT-qPCR	"hsa_circ_0072380 was significantly down-regulated in GDM placental tissues and in HG-treated JEG3 cells. The study showed that METTL3 regulates hsa_circ_0072380 through m6A modification, and hsa_circ_0072380 participates in controlling JEG3 proliferation, migration, and invasion under high-glucose conditions."	0.7475
39192392	Zhongguo shi yan xue ye xue za zhi	2024	[Expression and Function of circ_0073585 in Acute Myeloid Leukemia].	hsa_circ_0073585	circ_0073585	hsa_circ_APC	APC	acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	down-regulated	RT-qPCR	"circ_0073585 is down-regulated in bone marrow samples from AML patients and shows potential auxiliary diagnostic value. Functional assays in THP-1 cells indicate that circ_0073585 overexpression suppresses proliferation and viability, promotes apoptosis, and enhances sensitivity to homoharringtonine and daunorubicin, suggesting a potential tumor-suppressive and therapeutic role in AML."	0.6028
39206825	Neurological research	2024	Circ_0076490 silencing inhibits MAPK1 expression to decrease the proliferation and increase apoptosis of Jurkat cells by regulating miR-144-3p in myasthenia gravis.	hsa_circ_0076490	circ_0076490	hsa_circ_SRF	SRF	Myasthenia gravis 	MONDO:0009688	myasthenia gravis	up-regulated	RT-qPCR	"circ_0076490 is up-regulated in the peripheral blood of patients with myasthenia gravis. In Jurkat cells, circ_0076490 promotes proliferation and cell cycle progression while suppressing apoptosis by negatively regulating miR-144-3p and increasing MAPK1 expression, suggesting a potential therapeutic target for MG."	0.8119
39209049	Genomics	2024	Differentially expressed circular RNA profiles and comprehensive analysis of circRNA-miRNA-mRNA regulatory network in microsatellite instability-high endometrial cancer.	hsa_circ_0058230				microsatellite instability-high endometrial cancer 	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR; Microarray	"Hsa_circ_0058230 is up-regulated in MSI endometrial cancer and was validated in an in-house clinical cohort. It is implicated in immune regulation through positive associations with CD8+/CD3+ lymphocyte infiltration and cytotoxic effector molecules, and its predicted ceRNA clusters include hsa_circ_0058230-hsa-miR-98-5p-HOXC10 and hsa_circ_0058230-hsa-miR-1914-3p-GNAO1."	0.5047
39209049	Genomics	2024	Differentially expressed circular RNA profiles and comprehensive analysis of circRNA-miRNA-mRNA regulatory network in microsatellite instability-high endometrial cancer.	hsa_circ_0007874				microsatellite instability-high endometrial cancer 	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR; Microarray	Hsa_circ_0007874 was identified by circRNA array and validated by qRT-PCR as up-regulated in MSI EC compared with MSS EC. No specific mechanistic function was tested for this circRNA.	0.5541
39209049	Genomics	2024	Differentially expressed circular RNA profiles and comprehensive analysis of circRNA-miRNA-mRNA regulatory network in microsatellite instability-high endometrial cancer.	hsa_circ_0052318				microsatellite instability-high endometrial cancer 	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR; Microarray	Hsa_-circ_0052318 was reported as up-regulated in MSI EC by circRNA array and included among the qRT-PCR-validated DE-circRNAs. No specific downstream mechanism was reported.	0.5541
39209049	Genomics	2024	Differentially expressed circular RNA profiles and comprehensive analysis of circRNA-miRNA-mRNA regulatory network in microsatellite instability-high endometrial cancer.	hsa_circ_0005730				microsatellite instability-high endometrial cancer 	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR; Microarray	Hsa_circ_0005730 was identified and qRT-PCR validated as up-regulated in MSI EC versus MSS EC. No circRNA-specific mechanism was reported.	0.5541
39209049	Genomics	2024	Differentially expressed circular RNA profiles and comprehensive analysis of circRNA-miRNA-mRNA regulatory network in microsatellite instability-high endometrial cancer.	hsa_circ_0006168				microsatellite instability-high endometrial cancer 	MONDO:0011962	endometrial cancer	down-regulated	RT-qPCR; Microarray	Hsa_-circ_0006168 was reported as down-regulated in MSI EC and included among the qRT-PCR-validated differentially expressed circRNAs. No specific mechanism or functional assay was reported for this circRNA.	0.5541
39209049	Genomics	2024	Differentially expressed circular RNA profiles and comprehensive analysis of circRNA-miRNA-mRNA regulatory network in microsatellite instability-high endometrial cancer.	hsa_circ_0083766				microsatellite instability-high endometrial cancer 	MONDO:0011962	endometrial cancer	down-regulated	RT-qPCR; Microarray	Hsa_circ_0083766 was validated as down-regulated in MSI EC versus MSS EC. The article did not report a specific biological mechanism for this circRNA.	0.5541
39209049	Genomics	2024	Differentially expressed circular RNA profiles and comprehensive analysis of circRNA-miRNA-mRNA regulatory network in microsatellite instability-high endometrial cancer.	hsa_circ_0044837				microsatellite instability-high endometrial cancer 	MONDO:0011962	endometrial cancer	down-regulated	RT-qPCR; Microarray	Hsa_circ_0044837 was validated as down-regulated in MSI EC compared with MSS EC. No circRNA-specific downstream functional mechanism was tested.	0.5541
39209049	Genomics	2024	Differentially expressed circular RNA profiles and comprehensive analysis of circRNA-miRNA-mRNA regulatory network in microsatellite instability-high endometrial cancer.	hsa_circ_0008857				microsatellite instability-high endometrial cancer 	MONDO:0011962	endometrial cancer	down-regulated	RT-qPCR; Microarray	Hsa_circ_0008857 was validated as down-regulated in MSI EC relative to MSS EC. The study did not provide a circRNA-specific regulatory mechanism for it.	0.5541
39209049	Genomics	2024	Differentially expressed circular RNA profiles and comprehensive analysis of circRNA-miRNA-mRNA regulatory network in microsatellite instability-high endometrial cancer.	hsa_circ_0048977				microsatellite instability-high endometrial cancer 	MONDO:0011962	endometrial cancer	dysregulated	Microarray	Hsa_circ_0048977 was identified as a hub circRNA in the predicted MSI EC circRNA-miRNA-mRNA network. Its role is bioinformatically predicted and was not experimentally validated by qRT-PCR in the text.	0.329
39209049	Genomics	2024	Differentially expressed circular RNA profiles and comprehensive analysis of circRNA-miRNA-mRNA regulatory network in microsatellite instability-high endometrial cancer.	hsa_circ_0018722				microsatellite instability-high endometrial cancer 	MONDO:0011962	endometrial cancer	dysregulated	Microarray	Hsa_circ_0018722 was identified as a hub circRNA in a predicted circRNA-miRNA-mRNA regulatory network in MSI EC. The evidence is limited to circRNA array and bioinformatic network analysis.	0.329
39209049	Genomics	2024	Differentially expressed circular RNA profiles and comprehensive analysis of circRNA-miRNA-mRNA regulatory network in microsatellite instability-high endometrial cancer.	hsa_circ_0002810				microsatellite instability-high endometrial cancer 	MONDO:0011962	endometrial cancer	dysregulated	Microarray	"Hsa_circ_0002810 was identified as one of five hub circRNAs in the predicted MSI EC ceRNA network. The reported evidence is bioinformatic and array-based, without qRT-PCR validation for this specific circRNA."	0.329
39209049	Genomics	2024	Differentially expressed circular RNA profiles and comprehensive analysis of circRNA-miRNA-mRNA regulatory network in microsatellite instability-high endometrial cancer.	hsa_circ_0048148				microsatellite instability-high endometrial cancer 	MONDO:0011962	endometrial cancer	dysregulated	Microarray	Hsa_circ_0048148 was identified as a hub circRNA in the predicted MSI EC circRNA-miRNA-mRNA network. Its regulatory role remains predicted and was not experimentally validated in the provided text.	0.329
39215759	Journal of biochemical and molecular toxicology	2024	CircETV6 acts as an oncogenic driver in hepatocellular carcinoma progression.	hsa_circ_0004123		hsa_circ_ETV6	ETV6	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"CircETV6 is up-regulated in HCC tissues and cells and functions as an oncogenic circRNA. It promotes HCC proliferation, migration, invasion, cell cycle progression, tumor growth and metastasis while suppressing apoptosis, mainly through sponging miR-383-5p to increase PTPRE expression. High circETV6 expression is associated with poor overall survival and adverse clinicopathological features, suggesting potential therapeutic relevance."	0.8656
39219187	Biotechnology and applied biochemistry	2025	hsa_circ_0000129 targets miR-383-5p/tropomyosin 3 axis to facilitate ovarian cancer progression.	hsa_circ_0000129		hsa_circ_VPS72	VPS72	ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"hsa_circ_0000129 is up-regulated in ovarian cancer tissues and cell lines and is mainly localized in the cytoplasm. It promotes ovarian cancer cell viability, proliferation, migration, and xenograft tumor growth by sponging miR-383-5p and relieving repression of TPM3. The study supports hsa_circ_0000129 as an oncogenic circRNA in ovarian cancer through the hsa_circ_0000129/miR-383-5p/TPM3 ceRNA axis."	0.7795
39225594	Advances in clinical and experimental medicine : official organ Wroclaw Medical University	2025	Inhibiting circ_0000673 blocks the progression of colorectal cancer through downregulating CPSF6 via targeting miR-548b-3p.	hsa_circ_0000673		hsa_circ_RSL1D1	RSL1D1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0000673 is up-regulated in colorectal cancer tissues and cells and acts as a tumor-promoting circRNA. Mechanistically, it sponges miR-548b-3p to increase CPSF6 expression, thereby promoting CRC cell proliferation, migration, invasion, stemness and xenograft tumor growth. Clinically, high circ_0000673 expression is associated with poorer overall survival and may have prognostic or diagnostic biomarker value."	0.8201
39231318	Folia biologica	2024	circRACGAP1 Promotes Proliferation of Non-Small Cell Lung Cancer Cells through the miR-1296/CDK2 Pathway.		circRACGAP1	hsa_circ_RACGAP1	RACGAP1	Non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circRACGAP1 is up-regulated in NSCLC tissues and cell lines. It promotes NSCLC cell proliferation and cell-cycle progression while inhibiting apoptosis by sponging miR-1296 and increasing CDK2 expression, with downstream effects on Bcl2 and Bax. The study suggests circRACGAP1 may be a potential diagnostic and therapeutic target for NSCLC."	0.6521
39233264	Chemico-biological interactions	2024	Exosome-transmitted circ_0004664 suppresses the migration and invasion of cadmium-transformed human bronchial epithelial cells by regulating PTEN expression via miR-942-5p.	hsa_circ_0004664	circ_0004664	hsa_circ_SPAG16	SPAG16	cadmium-induced lung cancer 	MONDO:0021117	lung neoplasm	down-regulated	RT-qPCR; RNA-seq	"circ_0004664 is down-regulated in cadmium-transformed BEAS-2B cells and functions as a tumor-suppressive exosomal circRNA. Normal BEAS-2B cell-derived exosomes transfer circ_0004664 to cadmium-transformed cells, where it suppresses migration and invasion by competitively binding miR-942-5p and up-regulating PTEN expression."	0.717
39235355	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2024	Circ_0005397 inhibits ferroptosis of pancreatic cancer cells by up-regulating PCBP2 through KAT6A/H3K9Ac.	hsa_circ_0005397	circ_0005397 	hsa_circ_RHOT1	RHOT1	pancreatic cancer	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"This study identifies hsa_circ_0005397/circRHOT1 as an upregulated nuclear circRNA in pancreatic cancer associated with poor patient survival. EIF4A3 induces circ_0005397 expression, and circ_0005397 binds KAT6A to enhance H3K9ac-mediated PCBP2 transcription, thereby suppressing erastin-induced ferroptosis and supporting tumor progression. Knockdown of circ_0005397 sensitizes pancreatic cancer cells and xenograft tumors to ferroptosis, suggesting therapeutic and prognostic relevance."	0.8954
39236286	American journal of respiratory cell and molecular biology	2025	Circular RNA-Cacna1d Plays a Critical Role in Sepsis-induced Lung Injury by Sponging microRNA-185-5p.	mmu_circ_0005172	circRNA-Cacna1d	mmu_circ_Cacna1d	Cacna1d	sepsis-induced lung injury 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR; ISH; RNA-seq	Mouse circRNA-Cacna1d (mmu_circ_0005172) is up-regulated in lung tissue and blood in sepsis-induced lung injury. It promotes endothelial dysfunction and inflammation by sponging miRNA-185-5p and activating the RhoA/ROCK1 pathway; knockdown alleviates lung injury and improves survival in septic mice.	0.8709
39236286	American journal of respiratory cell and molecular biology	2025	Circular RNA-Cacna1d Plays a Critical Role in Sepsis-induced Lung Injury by Sponging microRNA-185-5p.	hsa_circ_0066187	circRNA-Cacna1d	hsa_circ_Cacna1d	Cacna1d	sepsis-induced lung injury 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR; ISH	"Human circRNA-Cacna1d (hsa_circ_0066187) is highly expressed in LPS-challenged HMEC-1 cells and shows dynamic changes in the blood of sepsis patients. It interacts with miRNA-185-5p and is implicated in RhoA/ROCK1-mediated endothelial inflammation and barrier dysfunction, with potential prognostic biomarker value in sepsis."	0.8364
39236286	American journal of respiratory cell and molecular biology	2025	Circular RNA-Cacna1d Plays a Critical Role in Sepsis-induced Lung Injury by Sponging microRNA-185-5p.		circRNA-Fkbp5	mmu_circ_Fkbp5	Fkbp5	sepsis-induced lung injury	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR; RNA-seq	circRNA-Fkbp5 was one of the candidate circRNAs identified by circRNA profiling and validated by qRT-PCR as up-regulated in lung tissues of mice with sepsis-induced lung injury. The article did not further investigate its mechanism or biological function.	0.279
39236286	American journal of respiratory cell and molecular biology	2025	Circular RNA-Cacna1d Plays a Critical Role in Sepsis-induced Lung Injury by Sponging microRNA-185-5p.		circRNA-Pik3r3	mmu_circ_Pik3r3	Pik3r3	sepsis-induced lung injury	MONDO:0005229	bacterial infectious disease with sepsis	down-regulated	RT-qPCR; RNA-seq	circRNA-Pik3r3 was one of the candidate circRNAs identified by circRNA profiling and validated by qRT-PCR as down-regulated in lung tissues of mice with sepsis-induced lung injury. The article did not further investigate its mechanism or biological function.	0.279
39243199	Journal of biochemical and molecular toxicology	2024	WTAP-mediated m6A modification of circ_0032463 promotes osteosarcoma progression by sponging miR-145-5p and regulating GFRA1 expression.	hsa_circ_0032463	circ_0032463	hsa_circ_SIPA1L1	SIPA1L1	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ_0032463 is up-regulated in osteosarcoma tissues and cells and mainly localizes in the cytoplasm. It promotes malignant OS phenotypes including proliferation, migration, invasion, angiogenesis, and in vivo tumor growth while suppressing apoptosis, partly through sponging miR-145-5p to regulate GFRA1. WTAP-mediated m6A modification increases circ_0032463 stability and expression, supporting a WTAP/circ_0032463/miR-145-5p/GFRA1 mechanism in OS progression."	0.8386
39243204	Journal of biochemical and molecular toxicology	2024	Circ_0004674 regulation of glycolysis and proliferation mechanism of osteosarcoma through miR-140-3p/TCF4 pathway.	hsa_circ_0004674	circ_0004674			osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ_0004674 is up-regulated in osteosarcoma tissues and cell lines. It promotes glycolysis, proliferation, migration and invasion while suppressing apoptosis through a miR-140-3p/TCF4 ceRNA axis, suggesting potential therapeutic relevance in osteosarcoma."	0.7177
39243601	Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy	2024	crVDAC3 alleviates ferroptosis by impeding HSPB1 ubiquitination and confers trastuzumab deruxtecan resistance in HER2-low breast cancer.	hsa_circ_0005927	crVDAC3 	hsa_circ_VDAC3	VDAC3	HER2-low breast cancer 	MONDO:0000618	Her2-receptor negative breast cancer	unknown	RT-qPCR	"crVDAC3 is a VDAC3-derived human circular RNA identified as a key mediator of T-DXd resistance in HER2-low breast cancer. It binds HSPB1 protein and blocks HSPB1 ubiquitination degradation, suppressing ferroptosis and thereby reducing T-DXd sensitivity. Paritaprevir disrupts the crVDAC3-HSPB1 interaction and enhances T-DXd efficacy in preclinical HER2-low breast cancer models."	0.8479
39254274	Advanced healthcare materials	2024	Intranasal Delivery of circATF7IP siRNA via Lipid Nanoparticles Alleviates LPS-induced Depressive-Like Behaviors.		circATF7IP 	hsa_circ_ATF7IP	ATF7IP	major depressive disorder 	MONDO:0002009	major depressive disorder	up-regulated	RT-qPCR; Microarray	"circATF7IP is upregulated in plasma from MDD patients and in depressed mouse models, and its level correlates with MDD severity and treatment outcome. Intranasal SALNP delivery of si-circATF7IP downregulates circATF7IP and alleviates LPS-induced depressive-like behaviors by reducing neuroinflammation, microglial activation, STAT3 nuclear translocation, and TNF-__/IL-6 production."	0.678
39254274	Advanced healthcare materials	2024	Intranasal Delivery of circATF7IP siRNA via Lipid Nanoparticles Alleviates LPS-induced Depressive-Like Behaviors.		circATF7IP 	mmu_circ_ATF7IP	ATF7IP	major depressive disorder 	MONDO:0002009	major depressive disorder	up-regulated	RT-qPCR; Microarray	"circATF7IP is upregulated in plasma from MDD patients and in depressed mouse models, and its level correlates with MDD severity and treatment outcome. Intranasal SALNP delivery of si-circATF7IP downregulates circATF7IP and alleviates LPS-induced depressive-like behaviors by reducing neuroinflammation, microglial activation, STAT3 nuclear translocation, and TNF-__/IL-6 production."	0.678
39254274	Advanced healthcare materials	2024	Intranasal Delivery of circATF7IP siRNA via Lipid Nanoparticles Alleviates LPS-induced Depressive-Like Behaviors.		circZBTB25	hsa_circ_ZBTB25	ZBTB25	major depressive disorder 	MONDO:0002009	major depressive disorder	up-regulated	Microarray	"circZBTB25 was identified by microarray as upregulated in plasma samples from MDD patients compared with healthy controls. Its level was positively correlated with HAMD-24 scores, but the paper did not experimentally investigate its mechanism or function."	0.2995
39254274	Advanced healthcare materials	2024	Intranasal Delivery of circATF7IP siRNA via Lipid Nanoparticles Alleviates LPS-induced Depressive-Like Behaviors.		circPARN	hsa_circ_PARN	PARN	major depressive disorder 	MONDO:0002009	major depressive disorder	up-regulated	Microarray	"circPARN was identified by microarray as upregulated in plasma samples from MDD patients compared with healthy controls. Its level was positively correlated with HAMD-24 scores, but the paper did not experimentally investigate its mechanism or function."	0.2995
39254274	Advanced healthcare materials	2024	Intranasal Delivery of circATF7IP siRNA via Lipid Nanoparticles Alleviates LPS-induced Depressive-Like Behaviors.		circKIAA0319L 	hsa_circ_KIAA0319L	KIAA0319L	major depressive disorder 	MONDO:0002009	major depressive disorder	up-regulated	Microarray	"circKIAA0319L was identified by microarray as upregulated in plasma samples from MDD patients compared with healthy controls. Unlike circZBTB25 and circPARN, the reported correlation with HAMD-24 scores was not significant, and the paper did not experimentally investigate its mechanism or function."	0.2995
39255925	Cellular signalling	2024	CircJPH1 regulates the NF-kappaB/HERC5 axis to promote the malignant progression of esophageal squamous cell carcinoma through binding to XRCC6.	hsa_circ_0137111	circJPH1	hsa_circ_JPH1	JPH1	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circJPH1, also reported as hsa_circ_0137111, is up-regulated in ESCC and high expression predicts poor overall survival. Functionally, circJPH1 promotes ESCC proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, it binds XRCC6, promotes XRCC6 nuclear translocation, activates NF-kappaB signaling, and increases HERC5 expression to drive malignant progression."	0.8897
39259911	American journal of physiology. Gastrointestinal and liver physiology	2024	Circular RNA RRM2 alleviates metabolic dysfunction-associated steatotic liver disease by targeting miR-142-5p to increase NRG1 expression.	hsa_circ_0052586	circRRM2 	hsa_circ_RRM2	RRM2	metabolic dysfunction-associated steatotic liver disease 	MONDO:0013209	metabolic dysfunction-associated steatotic liver disease	down-regulated	RT-qPCR	"circRRM2 is a human RRM2-derived circRNA that is downregulated in FFA-treated hepatocytes and HFD-induced MASLD mouse livers. Its overexpression alleviates MASLD-associated steatosis by sponging miR-142-5p, increasing NRG1 expression, and suppressing lipogenesis-related gene expression, triglyceride accumulation, lipid droplet formation, and inflammatory/pathological changes."	0.7712
39266461	IUBMB life	2024	CircSLC4A7 in resistant-cells-derived exosomes promotes docetaxel resistance via the miR-1205/MAPT axis in prostate cancer.	hsa_circ_0064618	circSLC4A7 	hsa_circ_SLC4A7	SLC4A7	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circSLC4A7 is up-regulated in docetaxel-resistant prostate cancer cells and their exosomes. It promotes docetaxel resistance by sponging miR-1205 and regulating MAPT, resulting in increased cell viability/colony formation and reduced apoptosis under docetaxel treatment. Silencing circSLC4A7 reduces resistance in vitro and in a cell line-derived xenograft model."	0.6443
39268977	"Hematology (Amsterdam, Netherlands)"	2024	Circular RNA_0003489 reflects unfavorable treatment response and shortened survival in newly diagnosed multiple myeloma patients who receive bortezomib-based induction therapy.	hsa_circ_0003489	Circular RNA_0003489 			multiple myeloma 	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR	"This retrospective clinical study found that circ_0003489 is up-regulated in bone marrow plasma cells from NDMM patients compared with donor controls. Higher circ_0003489 expression is associated with worse bortezomib-based induction therapy response, shortened PFS and OS, and independently poorer PFS, supporting its potential prognostic biomarker role."	0.5727
39276917	Cancer letters	2024	A tumor-promotional molecular axis CircMAPKBP1/miR-17-3p/TGFbeta2 activates autophagy pathway to drive tongue squamous cell carcinoma cisplatin chemoresistance.	hsa_circ_0034762	circMAPKBP1 	hsa_circ_MAPKBP1	MAPKBP1	tongue squamous cell carcinoma 	MONDO:0000500	tongue squamous cell carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circMAPKBP1/hsa_circ_0034762 is up-regulated in cisplatin-resistant TSCC tissues, cells, and patient-derived organoids. It promotes autophagy-mediated cisplatin chemoresistance by sponging miR-17-3p and increasing TGFbeta2 expression, while its knockdown restores cisplatin sensitivity in vitro and in vivo. Clinically, high circMAPKBP1 expression is associated with chemoresistance and poor PFS/OS in TSCC patients."	0.8981
39278405	The American journal of the medical sciences	2025	Hsa_circ_0087784 enhances non-small cell lung cancer progression via the miR-576-5p/CDCA4 axis.	hsa_circ_0087784	hsa_-circ_0087784 	hsa_circ_RNF20	RNF20	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; ISH	"hsa_circ_0087784 is up-regulated in NSCLC tissues and cell lines and is mainly localized in the cytoplasm. It promotes NSCLC proliferation, migration, invasion, lung metastasis and EMT-associated protein expression by sponging miR-576-5p to increase CDCA4 expression. The hsa_circ_0087784/miR-576-5p/CDCA4 loop is proposed as a potential therapeutic marker for NSCLC."	0.7373
39278446	International journal of biological macromolecules	2024	Circ_0084653 promotes the tumor progression and immune escape in triple-negative breast cancer via the deubiquitination of MYC and upregulation of SOX5.	hsa_circ_0084653	circ_0084653	hsa_circ_COPS5	COPS5	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"circ_0084653 is up-regulated in TNBC cells and promotes TNBC progression, including proliferation, migration, stemness and immune escape. Mechanistically, it recruits USP36 to deubiquitinate and stabilize MYC, thereby enhancing COPS5 transcription, and it also sponges miR-1323 to increase SOX5 expression; SOX5 further transcriptionally activates circ_0084653."	0.7159
39278782	Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology	2024	CircFLNA facilitates gastric cancer cell proliferation and glycolysis via regulating SOX5 by sponging miR-1200.	hsa_circ_0091994	circ_0091994 	hsa_circ_FLNA	FLNA	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circFLNA is upregulated in gastric cancer tissues and cell lines, and high expression is associated with poorer overall survival. Functionally, circFLNA promotes GC cell proliferation, glycolysis and in vivo tumor growth while suppressing apoptosis. Mechanistically, circFLNA acts as a sponge for miR-1200 to increase SOX5 expression, forming a circFLNA/miR-1200/SOX5 regulatory axis."	0.7793
39283585	Cell biochemistry and biophysics	2024	hsa_circ_0072309 Inhibits Oncogenesis in Hepatocellular Carcinoma by Epigenetic Activation of its Host Gene.	hsa_circ_0072309		hsa_circ_LIFR		hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0072309 is downregulated in HCC tissues, serum samples, and HCC cell lines, and serum expression shows diagnostic potential. Functionally, it suppresses HCC cell proliferation, migration, invasion, and sorafenib resistance. Mechanistically, hsa_circ_0072309 binds p300 and promotes H3K27ac enrichment at the LIFR enhancer to activate LIFR transcription, forming a positive feedback regulatory loop with its host gene LIFR."	0.8625
39284259	Environment international	2024	Circ_0025373 inhibits carbon black nanoparticles-induced malignant transformation of human bronchial epithelial cells by affecting DNA damage through binding to MSH2.	hsa_circ_0025373	circ_0025373	hsa_circ_RIMKLB	RIMKLB	CBNP-induced malignant transformation of human bronchial epithelial cells 	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circ_0025373 is up-regulated during CBNP-induced malignant transformation of human bronchial epithelial cells and in lung cancer cells. It acts as a protective regulator by binding MSH2, modulating MSH2 expression and subcellular distribution, reducing DNA damage, and inhibiting malignant transformation-associated proliferation, migration, anchorage-independent growth, and transformation."	0.7918
39288082	Cancer research	2024	CircRREB1 Mediates Metabolic Reprogramming and Stemness Maintenance to Facilitate Pancreatic Ductal Adenocarcinoma Progression.	hsa_circ_0001573	circRREB1	hsa_circ_RREB1	RREB1	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; Northern Blot; ISH; RNA-seq	"CircRREB1 is a human RREB1-derived oncogenic circRNA upregulated in PDAC and associated with advanced disease, higher glucose uptake, diagnostic potential, and poor survival. It promotes glycolysis by binding PGK1 and preventing PTEN-mediated PGK1 Y324 dephosphorylation, and it maintains stemness by binding YBX1/NUP153, facilitating YBX1 nuclear translocation, activating WNT7B transcription, and stimulating Wnt/beta-catenin signaling. Targeting circRREB1 with ASOs suppresses PDAC cell, organoid, xenograft, and PDX growth, supporting its value as a therapeutic target."	0.9071
39288851	International journal of biological macromolecules	2024	circE2F1-encoded peptide inhibits circadian machinery essential for nucleotide biosynthesis and tumor progression via repressing SPIB/E2F1 axis.	hsa_circ_0059873	circE2F1 	hsa_circ_E2F1	E2F1	neuroblastoma 	MONDO:0005072	neuroblastoma	down-regulated	RT-qPCR; ISH	"circE2F1 (hsa_circ_0059873), derived from E2F1, is down-regulated in neuroblastoma and encodes the tumor-suppressive peptide E2F1-99aa. E2F1-99aa binds SPIB and blocks the SPIB-E2F1 interaction, thereby repressing CRY1/TIMELESS circadian machinery, DHODH/PAICS/PPAT-mediated nucleotide biosynthesis, NB cell growth, invasion, xenograft tumorigenesis, and metastasis."	0.8811
39288863	International journal of biological macromolecules	2024	Inflammatory factor TNFalpha-induced circDMD mediates R-loop formation to promote tumorigenesis.		circDMD	hsa_circ_DMD	DMD	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; RNA-seq	"circDMD is a TNFalpha-induced circRNA derived from DMD that promotes cervical cancer tumorigenesis. It activates NF-kappaB signaling through P65/P50 interaction, a miR-4711-5p/KDM5A/SOCS1 ubiquitination-related mechanism, and R-loop formation at the VEGFR3 promoter, thereby enhancing proliferation, metastasis, autophagy, angiogenesis, and xenograft tumor growth."	0.8599
39291620	Journal of biochemical and molecular toxicology	2024	Helicobacter pylori induce circ_0046854 to regulate microRNA-511-3p/CSF1 axis and enhance the resistance of gastric cancer to cisplatin.	hsa_circ_0046854		hsa_circ_ANKRD12	ANKRD12	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"In this study, circ_0046854 is a human ANKRD12-derived circRNA up-regulated in gastric cancer, especially HP-positive gastric cancer. Helicobacter pylori induces circ_0046854 through CagA, and circ_0046854 promotes GC cell growth, invasion, migration, anti-apoptosis, tumor growth, and cisplatin/DDP resistance by sponging miR-511-3p and regulating CSF1. Silencing circ_0046854 suppresses tumor growth and enhances the anti-tumor effect of DDP, suggesting the circ_0046854/miR-511-3p/CSF1 axis as a potential therapeutic target for HP-associated GC."	0.8571
39293992	Zhonghua zhong liu za zhi [Chinese journal of oncology]	2024	[hsa_circ_0001776 targeting miR-1265 regulates the development of lung squamous cell carcinoma and clinical significance].	hsa_circ_0001776	circ_0001776			lung squamous cell carcinoma 	MONDO:0005097	squamous cell lung carcinoma	down-regulated	RT-qPCR; ISH	"hsa_circ_0001776 is downregulated in lung squamous cell carcinoma plasma, tissues, and cell lines. Functionally, hsa_circ_0001776 suppresses tumor cell proliferation, colony formation, migration, invasion, and xenograft tumor growth while promoting apoptosis, mainly through targeting and inhibiting miR-1265. Its low expression is associated with clinical features including lymph node metastasis, clinical stage, and tumor stage, suggesting potential diagnostic and therapeutic value."	0.7799
39303926	International journal of cardiology	2024	"Correlation between serum levels of circ_0001879 and circ_0004104, coronary microcirculation disorders and prognosis after percutaneous coronary intervention (PCI) in patients with stable coronary heart disease."	hsa_circ_0001879	circ_0001879			stable coronary heart disease 	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR	"Serum circ_0001879 was elevated in stable coronary heart disease patients with coronary microcirculation disturbance and was associated with unfavorable post-PCI prognosis. The study supports circ_0001879 as a clinical prognostic biomarker, but did not experimentally define a molecular regulatory mechanism."	0.4758
39303926	International journal of cardiology	2024	"Correlation between serum levels of circ_0001879 and circ_0004104, coronary microcirculation disorders and prognosis after percutaneous coronary intervention (PCI) in patients with stable coronary heart disease."	hsa_circ_0004104	circ_0004104			stable coronary heart disease 	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR	"Serum circ_0004104 was elevated in stable coronary heart disease patients with coronary microcirculation disturbance and was associated with unfavorable post-PCI prognosis. The study supports circ_0004104 as a clinical prognostic biomarker, but did not experimentally define a molecular regulatory mechanism."	0.4758
39304099	Cellular signalling	2024	CircHIPK3 regulates cementoblast differentiation via the miR-10b-5p/DOHH/NF-kappaB axis.	mmu_circ_0001052	circHIPK3	mmu_circ_Hipk3	Hipk3	cementum damage 	MONDO:0006999	tooth disorder	down-regulated	RT-qPCR	"This study identifies murine circHIPK3 as a positive regulator of cementoblast differentiation and mineralization. Under inflammatory conditions such as TNF-alpha exposure and apical periodontitis, circHIPK3 is down-regulated, and restoring circHIPK3 partly rescues impaired cementoblast differentiation. Mechanistically, circHIPK3 functions as a ceRNA that sponges miR-10b-5p, increases DOHH expression, and activates the NF-kappaB pathway."	0.8462
39307294	Molecular and cellular probes	2024	Identification of circRNA-mediated competing endogenous RNA network involved in the development of cervical cancer.	hsa_circ_0000069	circ_0000069			cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	Microarray	hsa_circ_0000069/circ_0000069 was identified as an up-regulated differentially expressed circRNA in cervical cancer GEO microarray datasets. The study did not experimentally validate its function or mechanism.	0.1768
39307294	Molecular and cellular probes	2024	Identification of circRNA-mediated competing endogenous RNA network involved in the development of cervical cancer.	hsa_circ_0005576	circ_0005576			cervical cancer 	MONDO:0002974	cervical cancer	dysregulated	Microarray	"circ_0005576 was identified among overlapping differentially expressed circRNAs in cervical cancer GEO microarray datasets, but showed opposite expression patterns across the two datasets. It was not experimentally validated or included in the authors' final ceRNA validation experiments."	0.1768
39307294	Molecular and cellular probes	2024	Identification of circRNA-mediated competing endogenous RNA network involved in the development of cervical cancer.	hsa_circ_0068075	circ_0068075			cervical cancer 	MONDO:0002974	cervical cancer	dysregulated	Microarray	"circ_0068075 was identified among overlapping differentially expressed circRNAs in cervical cancer GEO microarray datasets, but its direction was not consistent across the two datasets. The study did not validate its biological function or mechanism."	0.1768
39307294	Molecular and cellular probes	2024	Identification of circRNA-mediated competing endogenous RNA network involved in the development of cervical cancer.	hsa_circ_0001446	circ_0001446			cervical cancer 	MONDO:0002974	cervical cancer	down-regulated	Microarray	"circ_0001446 was a down-regulated circRNA with a consistent expression trend in the two cervical cancer GEO datasets. It was included in the predicted circRNA-miRNA-mRNA network, but no individual RT-qPCR or functional validation was reported."	0.1768
39307294	Molecular and cellular probes	2024	Identification of circRNA-mediated competing endogenous RNA network involved in the development of cervical cancer.	hsa_circ_0087429	circ_0087429			cervical cancer 	MONDO:0002974	cervical cancer	down-regulated	Microarray	"circ_0087429 was a down-regulated circRNA with a consistent expression trend in the two cervical cancer GEO datasets. It was included in the predicted circRNA-miRNA-mRNA network, but no individual RT-qPCR or functional validation was reported."	0.1768
39307294	Molecular and cellular probes	2024	Identification of circRNA-mediated competing endogenous RNA network involved in the development of cervical cancer.	hsa_circ_0002828	circ_0002828			cervical cancer 	MONDO:0002974	cervical cancer	down-regulated	Microarray	"circ_0002828 was a down-regulated circRNA with a consistent expression trend in the two cervical cancer GEO datasets. It was included in the predicted circRNA-miRNA-mRNA network, but no individual RT-qPCR or functional validation was reported."	0.1768
39307294	Molecular and cellular probes	2024	Identification of circRNA-mediated competing endogenous RNA network involved in the development of cervical cancer.	hsa_circ_0008193	circ_0008193 	hsa_circ_FAM120A	FAM120A	cervical cancer 	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0008193/circ_0008193 is down-regulated in cervical cancer cells and acts as a suppressive circRNA in this study. Mechanistically, it functions in a circ_0008193-miR-182-5p-PTEN ceRNA axis, with circ_0008193 overexpression inhibiting cervical cancer cell proliferation, migration, and invasion."	0.5804
39321710	"Pathology, research and practice"	2024	circ_0006089 facilitates gastric cancer progression and oxaliplatin resistance via miR-217/NRP1.	hsa_circ_0006089	circ_0006089 	hsa_circ_ASAP2	ASAP2	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_0006089 is up-regulated in oxaliplatin-resistant gastric cancer tissues and cells. It promotes GC progression, tumor growth, migration, invasion, and oxaliplatin resistance by sponging miR-217 and increasing NRP1 expression. High circ_0006089 expression is associated with poorer prognosis and adverse clinicopathological features."	0.7548
39328069	Archives of physiology and biochemistry	2025	Regulatory effect and mechanism of CircSEC24A in IL-1beta-induced osteoarthritis.	hsa_circ_0128006		hsa_circ_SEC24A	SEC24A	Osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circSEC24A is up-regulated in OA cartilage tissues and IL-1beta-treated CHON-001 chondrocytes. It promotes IL-1beta-induced chondrocyte injury by enhancing oxidative stress, apoptosis, ECM degradation, and inflammation while reducing cell viability. Mechanistically, circSEC24A acts as a miR-515-5p sponge to increase NAMPT expression, forming a circSEC24A/miR-515-5p/NAMPT ceRNA axis."	0.8111
39332589	Cancer letters	2024	NSUN4-mediated m5C modification of circERI3 promotes lung cancer development by altering mitochondrial energy metabolism.	hsa_circ_0012144	circERI3	hsa_circ_ERI3	ERI3	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; RNA-seq	"circERI3 is up-regulated in lung cancer tissues and cell lines and is associated with tumour size, disease stage, diagnostic performance, and poor overall survival. Mechanistically, NSUN4-mediated m5C modification promotes circERI3 nuclear export, and cytoplasmic circERI3 binds DDB1 to reduce DDB1 ubiquitination and enhance DDB1 stability, thereby increasing PGC-1alpha transcription and mitochondrial energy metabolism. Functionally, circERI3 promotes lung cancer proliferation, cell cycle progression, migration, tumour growth, and mitochondrial biogenesis while inhibiting apoptosis."	0.9053
39341990	Oncogene	2024	Targeting CircAURKA prevents colorectal cancer progression via enhancing CTNNB1 protein degradation.	hsa_circ_0008777	circ4953 	hsa_circ_AURKA	AURKA	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"CircAURKA (hsa_circ_0008777), derived from AURKA, is up-regulated in CRC tissues, cells and serum and is associated with poorer prognosis, lymph node metastasis and potential diagnostic value. Functionally, it promotes CRC proliferation, invasion and metastasis in vitro and in vivo. Mechanistically, circAURKA promotes ACLY-CTNNB1 interaction, inhibits CTNNB1 ubiquitination/degradation, supports Wnt/beta-catenin-related downstream effects, and its own stability is regulated by m6A modification."	0.9026
39342687	Reproductive biology	2024	Hsa_circ_0043533 modulates apoptosis and viability of granulosa cells via miR-409-3p/BCL2 and EMT signalling in PCOS: Providing novel perspective of metformin.	hsa_circ_0043533	hsa_circ_043533 			PCOS 	MONDO:0008487	polycystic ovary syndrome	up-regulated	RT-qPCR	"hsa_circ_0043533 is up-regulated in PCOS granulosa cells and functions as a promoter of granulosa cell survival, proliferation and migration while suppressing apoptosis. Mechanistically, it competitively binds miR-409-3p to upregulate BCL2 and modulate mitochondrial apoptosis and EMT-related markers; metformin can intervene in this axis by regulating miR-409-3p."	0.6542
39351864	Spine	2024	CircTMTC1 Mediates Nucleocytoplasmic Translocation of DDX3X to Regulate Osteogenic Differentiation of Human Ligamentum Flavum Cells.	hsa_circ_0025768	circTMTC1	hsa_circ_TMTC1	TMTC1	Ossification of the ligamentum flavum 	MONDO:0045044	ligament disorder	up-regulated	RT-qPCR; RNA-seq	"circTMTC1 (hsa_circ_0025768) is up-regulated during osteogenic differentiation of human ligamentum flavum cells in the context of OLF. It promotes osteogenic differentiation by directly interacting with the RNA-binding protein DDX3X, enhancing DDX3X nucleo-cytoplasmic translocation, and activating the NLRP3 inflammasome pathway."	0.7818
39354288	"Reproductive sciences (Thousand Oaks, Calif.)"	2025	Circ_0015382 Regulates the miR-942-5p/NDRG1 Axis to Suppress Trophoblast Cell Functions.	hsa_circ_0015382	Circ_0015382	hsa_circ_PAPPA2	PAPPA2	preeclampsia 	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR	"Circ_0015382 is up-regulated in placental tissues from PE patients. Functionally, circ_0015382 suppresses trophoblast cell proliferation, invasion, and angiogenesis, thereby promoting PE progression. Mechanistically, it sponges miR-942-5p to regulate NDRG1 expression through the circ_0015382/miR-942-5p/NDRG1 axis."	0.7591
39357702	International journal of biological macromolecules	2024	Circ_0104873 promotes osteoarthritis progression via miR-875-5p/NOTCH3/Notch signaling pathway.	hsa_circ_0104873	circ-IQGAP1 	hsa_circ_IQGAP1	IQGAP1	osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circ_0104873 is up-regulated during osteogenic differentiation of human BMSCs in an OA-related cell model. It promotes BMSC proliferation and osteogenic differentiation by acting as a cytoplasmic ceRNA that sponges miR-875-5p, up-regulates NOTCH3, and activates the Notch signaling pathway. The study suggests the circ_0104873/miR-875-5p/NOTCH3/Notch axis as a potential therapeutic target for OA."	0.7998
39370077	International journal of biological macromolecules	2024	"Immune infiltration related circular RNA, circGLIS2, facilitated progression of endometriosis through miR-4731-5p/IL-1beta axis."		circGLIS2 	hsa_circ_GLIS2	GLIS2	endometriosis 	MONDO:0005133	endometriosis	up-regulated	RT-qPCR; RNA-seq	Human circGLIS2 is up-regulated in endometriosis tissues and correlates with clinicopathologic features including rASRM staging/scoring and dysmenorrhoea. It predominantly localizes in the cytoplasm and promotes immune cell infiltration by sponging miR-4731-5p to increase IL-1beta expression and secretion.	0.8748
39370077	International journal of biological macromolecules	2024	"Immune infiltration related circular RNA, circGLIS2, facilitated progression of endometriosis through miR-4731-5p/IL-1beta axis."		MS-CIRCGLIS2 	mmu_circ_GLIS2	GLIS2	endometriosis 	MONDO:0005133	endometriosis	unknown	RT-qPCR	"Mouse mmu-circ-0006310, described as corresponding to mouse circGLIS2, was functionally tested in a BALB/c endometriosis model. Knockdown of mmu-circ-0006310 reduced IL-1beta expression, decreased lesion size and weight, and lowered immune cell infiltration in endometriotic lesions."	0.5214
39384044	Toxicology and applied pharmacology	2024	Circ_0049979 ameliorates myocardial infarction through improving Cx43-mediated endothelial functions.	hsa_circ_0049979	circ_0049979 	hsa_circ_ANO8	ANO8	coronary atherosclerotic heart disease 	MONDO:0005010	coronary artery disorder	down-regulated	RT-qPCR; ISH	"circ_0049979 is downregulated in oxLDL-induced endothelial injury and in coronary atherosclerotic myocardial infarction models. Its overexpression improves endothelial viability, migration, and tube formation while reducing apoptosis, plaque lipid deposition, and infarct size, mainly through the miR-653/Cx43 axis."	0.6745
39389065	Molecular cell	2024	BRCA1 levels and DNA-damage response are controlled by the competitive binding of circHIPK3 or FMRP to the BRCA1 mRNA.	hsa_circ_0000284	circHIPK3 	hsa_circ_HIPK3	HIPK3	rhabdomyosarcoma 	MONDO:0005212	rhabdomyosarcoma	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in rhabdomyosarcoma cells and patient tumor samples and is studied as a tumor-associated human circRNA across multiple cancer models. It directly binds BRCA1 mRNA through its back-splicing junction, competes with FMRP-mediated translational repression, and thereby supports BRCA1 protein production and DNA-damage response. Depletion or disruption of circHIPK3-BRCA1 interaction lowers BRCA1 levels, increases DNA damage, and sensitizes cancer cells to DNA-damage-inducing agents and PARP inhibition."	0.8311
39396594	International journal of biological macromolecules	2024	Hsa_circ_0007718 facilitates the progression of colorectal cancer by regulating the miR-1299/PSMC2 axis.	hsa_circ_0007718	circ_0007718 	hsa_circ_MID1	MID1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"Hsa_circ_0007718/circ_0007718 is up-regulated in colorectal cancer tissues and cell lines. It promotes CRC progression by sponging miR-1299 and increasing PSMC2 expression, thereby enhancing proliferation, migration, EMT, tumor growth and lung metastasis while suppressing apoptosis. The study suggests circ_0007718 may be a potential therapeutic target for CRC."	0.7938
39400106	Epigenomics	2024	"circ_0006988 promotes gastric cancer cell proliferation, migration and invasion through miRNA-92a-2-5p/TFAP4 axis."	hsa_circ_0006988	circ_0006988 	hsa_circ_LDLRAD3	LDLRAD3	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_0006988 is up-regulated in gastric cancer tissues and cell lines. It promotes GC cell proliferation, migration, invasion and xenograft tumor growth by sponging miRNA-92a-2-5p and increasing TFAP4 expression, suggesting a potential therapeutic target role in GC."	0.7756
39401767	Journal of molecular recognition : JMR	2025	Role of Circular RNA MMP9 in Glioblastoma Progression: From Interaction With hnRNPC and hnRNPA1 to Affecting the Expression of BIRC5 by Sequestering miR-149.	hsa_circ_0001162	circMMP9 	hsa_circ_MMP9	MMP9	Glioblastoma multiforme 	MONDO:0018177	glioblastoma	unknown	Microarray	"This study proposes circMMP9/hsa_circ_0001162 as an oncogenic circRNA and potential therapeutic target in glioblastoma. Through bioinformatic prediction and human data analysis, circMMP9 is suggested to sponge miR-149-5p and miR-542-5p, rescue BIRC5 expression, promote proliferation, and suppress apoptosis. It is also predicted to interact with hnRNPC and hnRNPA1 RNA-binding proteins, potentially contributing to GBM progression."	0.348
39405804	"Pathology, research and practice"	2024	Circ_0038718 augments colorectal cancer progression through mediating the miR-761/miR-214-3p/ITGA6 axis.	hsa_circ_0038718	circ_0038718 			colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circ_0038718 is up-regulated in colorectal cancer tissues and cell lines, and high expression is associated with poorer patient survival and more malignant clinicopathologic features. Functionally, circ_0038718 promotes CRC cell proliferation, migration and in vivo tumor growth while suppressing apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-761 and miR-214-3p to increase ITGA6 expression."	0.8238
39417968	Clinical & experimental metastasis	2024	Downregulation of hsa_circ_0006620 inhibits the malignant progression of prostate cancer by regulation of the miR-502-3p/HK2 axis mediated by aerobic glycolysis.	hsa_circ_0006620	circ-ITM2B	hsa_circ_ITM2B	ITM2B	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"hsa_circ_0006620 is up-regulated in prostate cancer tissues and cell lines and is localized in the cytoplasm. It promotes prostate cancer proliferation, migration, tumor growth, and lung metastasis by sponging miR-502-3p to increase HK2 expression and enhance aerobic glycolysis. Silencing hsa_circ_0006620 suppresses malignant progression, suggesting the hsa_circ_0006620/miR-502-3p/HK2 axis may be a therapeutic target."	0.7955
39420826	The International journal of biological markers	2024	CircLPHN3 correlates with prognosis in colorectal cancer and regulates cellular processes by targeting miR-142-5p.	hsa_circ_0069865	circLPHN3 	hsa_circ_LPHN3	LPHN3	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"circLPHN3 (hsa_circ_0069865), derived from LPHN3, is downregulated in colorectal cancer tissues and cell lines. It functions as a tumor suppressor by negatively regulating miR-142-5p, thereby curbing CRC cell proliferation, migration, and invasion, with LDB2 identified as a downstream target of miR-142-5p. Clinically, reduced circLPHN3 is associated with advanced TNM stage, lymph node metastasis, and shorter survival, supporting its value as a prognostic biomarker."	0.7588
39422230	The British journal of dermatology	2025	"Circular RNA circASH1L(4,5) protects microRNA-129-5p from target-directed microRNA degradation in human skin wound healing."	hsa_circ_0003247	"circASH1L(4,5) "	hsa_circ_ASH1L	ASH1L	human skin wound healing 	MONDO:0005093	skin disorder	up-regulated	RT-qPCR; RNA-seq	"circASH1L(4,5), a human ASH1L-derived circRNA, is upregulated in keratinocytes during acute skin wound healing and is low in chronic wounds. It binds miR-129-5p and stabilizes it by protecting it from NR6A1 mRNA-triggered target-directed miRNA degradation, thereby enhancing miR-129 silencing activity against targets such as THRA. Functionally, the circASH1L-miR-129 axis promotes keratinocyte migration, proliferation and wound re-epithelialization."	0.8379
39427585	"Pathology, research and practice"	2024	CircWDR37 promotes hepatocellular carcinoma tumorigenesis by mediating the miR-646/TRAF4 regulatory pathway.	hsa_circ_0004277	circWDR37	hsa_circ_WDR37	WDR37	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circWDR37 is up-regulated in hepatocellular carcinoma tissues and cells and is associated with more advanced clinical stage. Functionally, circWDR37 promotes malignant phenotypes including proliferation, migration, invasion, angiogenesis and xenograft tumor growth while suppressing apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-646, thereby increasing TRAF4 expression and driving HCC progression."	0.8635
39442967	Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology	2024	[Serum from Xinfeng Capsule-treated rats affect the proliferation and apoptosis of fibroblast-like synoviocytes in rheumatoid arthritis by regulating circular RNA Cbl proto-oncogene B (circ-CBLB)].		circular RNA Cbl proto-oncogene B 	hsa_circ_CBLB		rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	down-regulated	RT-qPCR	"In this RA-FLS model, circ-CBLB is down-regulated under TNF-alpha-induced disease-like conditions, while Xinfeng Capsule-containing serum increases circ-CBLB expression. circ-CBLB overexpression suppresses RA-FLS viability/proliferation, promotes apoptosis, alters cell-cycle distribution, and shifts cytokine production toward an anti-inflammatory profile."	0.421
39451176	Polish journal of pathology : official journal of the Polish Society of Pathologists	2024	"CircRNA TUBA1C promotes proliferation and glucose metabolism, and blocks apoptosis of osteosarcoma cells through sponging miR-143-3p."	hsa_circ_0026134	circTUBA1C 	hsa_circ_TUBA1C	TUBA1C	Osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circTUBA1C is upregulated in osteosarcoma tissues and cell lines. It promotes OS cell proliferation, glucose metabolism and xenograft tumour growth while suppressing apoptosis, mainly by sponging miR-143-3p. The study suggests circTUBA1C as a potential OS biomarker and therapeutic target."	0.6996
39454632	"Shock (Augusta, Ga.)"	2025	CIRCTMCO3 ALLEVIATES SEPSIS-INDUCED ACUTE KIDNEY INJURY VIA REGULATING MIR-218-5P/ZEB2 AXIS.	hsa_circ_0007760	CircTMCO3	hsa_circ_TMCO3	TMCO3	sepsis-induced acute kidney injury 	MONDO:0005229	bacterial infectious disease with sepsis	down-regulated	RT-qPCR	"CircTMCO3 is down-regulated in LPS-induced HK-2 cells and CLP-induced mouse kidney tissues. Its overexpression protects against S-AKI by reducing apoptosis, oxidative stress and inflammatory cytokine production, acting through a circTMCO3/miR-218-5p/ZEB2 regulatory axis."	0.6964
39454632	"Shock (Augusta, Ga.)"	2025	CIRCTMCO3 ALLEVIATES SEPSIS-INDUCED ACUTE KIDNEY INJURY VIA REGULATING MIR-218-5P/ZEB2 AXIS.	mmu_circ_0007760	CircTMCO3	 mmu_circ_TMCO3	TMCO3	sepsis-induced acute kidney injury 	MONDO:0005229	bacterial infectious disease with sepsis	down-regulated	RT-qPCR	"CircTMCO3 is down-regulated in LPS-induced HK-2 cells and CLP-induced mouse kidney tissues. Its overexpression protects against S-AKI by reducing apoptosis, oxidative stress and inflammatory cytokine production, acting through a circTMCO3/miR-218-5p/ZEB2 regulatory axis."	0.6964
39455349	Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology	2024	Hsa_circ_0008667 promotes progression and improves the prognosis of gastric cancer by inhibiting miR-9-5p.	hsa_circ_0008667	hsa_-circ_0008667 	hsa_circ_ADAMTS6	ADAMTS6	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"hsa_circ_0008667 is up-regulated in gastric cancer tissues and cells and its high expression is associated with lymph node metastasis, advanced TNM stage, and poor survival. Functionally, hsa_circ_0008667 promotes GC cell proliferation, migration, invasion, and metastasis, mainly through negative regulation of miR-9-5p. The study supports hsa_circ_0008667 as a prognostic biomarker and potential therapeutic target for GC."	0.7752
39461578	Cellular signalling	2025	Hsa_circ_0048764 facilitates the progression of non-small cell lung cancer by targeting miR-1178-3p/HMGA1 axis.	hsa_circ_0048764	circ_0048764			non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0048764/circ_0048764 is up-regulated in NSCLC tissues and cell lines and its high expression is associated with poorer overall survival. Functionally, circ_0048764 promotes NSCLC proliferation, migration/metastasis and xenograft tumor growth while suppressing apoptosis. Mechanistically, it sponges miR-1178-3p to enhance HMGA1 expression, forming a circ_0048764/miR-1178-3p/HMGA1 regulatory axis."	0.8298
39461579	Cellular signalling	2025	Epithelial splicing regulatory protein 1 promotes peritoneal dissemination of ovarian cancer by inducing the formation of circular RNAs modulating epithelial plasticity.		circPAFAH1B2 	hsa_circ_PAFAH1B2	PAFAH1B2	ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; RNA-seq	"circPAFAH1B2 is an ESRP1-induced circular RNA in ovarian cancer cells. It promotes proliferation and epithelial plasticity while restricting migration and invasion in vitro, and mechanistically works with IGF2BP2 to stabilize DKK3 and AHR mRNAs, supporting peritoneal dissemination."	0.7872
39461579	Cellular signalling	2025	Epithelial splicing regulatory protein 1 promotes peritoneal dissemination of ovarian cancer by inducing the formation of circular RNAs modulating epithelial plasticity.		circUBAP2 	hsa_circ_UBAP2	UBAP2	ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; RNA-seq	"circUBAP2 is an ESRP1-induced circular RNA in ovarian cancer cells. It promotes proliferation and epithelial plasticity while restricting migration and invasion in vitro, and mechanistically works with IGF2BP2 to stabilize DKK3 and AHR mRNAs, supporting peritoneal dissemination."	0.7872
39461579	Cellular signalling	2025	Epithelial splicing regulatory protein 1 promotes peritoneal dissemination of ovarian cancer by inducing the formation of circular RNAs modulating epithelial plasticity.		circCHSY1	hsa_circ_CHSY1	CHSY1	ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; RNA-seq	"circCHSY1 is a human ovarian cancer cell circRNA induced by ESRP1-mediated RNA looping. Although its expression was increased by ESRP1 and experimentally validated, its individual modulation of ovarian cancer EMP, proliferation, and invasion was limited or insignificant compared with circPAFAH1B2 and circUBAP2."	0.7872
39462446	"Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer"	2025	Expression and Significance of the Circular RNA circ_0001438 in the Development of Gastric Cancer.	hsa_circ_0001438	circular RNA 0001438 			gastric cancer	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"circ_0001438 is downregulated in gastric cancer tissues and cells. Its overexpression suppresses gastric cancer cell proliferation, migration, invasion, and metastasis, at least partly by sponging/downregulating miR-1290. Clinically, low circ_0001438 expression is associated with larger tumor size, TNM stage, lymph node metastasis, and poorer 5-year survival."	0.7081
39462448	"Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer"	2025	Analysis of the Clinical Value of hsa_circ_0001955 in Papillary Thyroid Cancer Treated with 131 Iodine.	hsa_circ_0001955	circ_0001955	hsa_circ_CSNK1G1	CSNK1G1	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"This study identifies serum hsa_circ_0001955/circ_0001955 as up-regulated in PTC patients compared with multinodular goiter patients and healthy controls. Elevated serum circ_0001955 is associated with TNM stage and WBS-positive status after iodine-131 therapy, and it may serve as a diagnostic and recurrence-prediction biomarker, particularly when combined with Tg and TgAb. The study did not define a molecular regulatory mechanism for circ_0001955 in PTC."	0.5121
39465333	Gene therapy	2025	The circRNA circSCAF8 promotes tumor growth and metastasis of gastric cancer via miR-1293/TIMP1signaling.	hsa_circ_0078362	circSCAF8	hsa_circ_SCAF8	SCAF8	gastric cancer	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circSCAF8 is up-regulated in gastric cancer tissues and cells and is associated with lymph node metastasis and poor overall survival. Functionally, circSCAF8 promotes gastric cancer proliferation, invasion, migration, xenograft tumor growth and lung metastasis. Mechanistically, it sponges miR-1293 without changing miR-1293 abundance, thereby increasing TIMP1 expression."	0.8709
39466543	Archives of pharmacal research	2024	Ginsenoside Rg3 activates the immune function of CD8+_T cells via circFOXP1-miR-4477a-PD-L1 axis to induce ferroptosis in gallbladder cancer.		circFOXP1 	hsa_circ_FOXP1	FOXP1	gallbladder cancer 	MONDO:0005411	gallbladder cancer	up-regulated	RT-qPCR	"circFOXP1 is upregulated in GBC tumor tissues and functions as a miR-4477a sponge to increase PD-L1 expression. Through this circFOXP1-miR-4477a-PD-L1 axis, it suppresses CD8+ T cell activity and limits ferroptosis and apoptosis in GBC cells; Rg3 counteracts this axis by downregulating circFOXP1."	0.7554
39467079	ACS nano	2024	Nanocarriers Targeting Circular RNA ADARB1 Boost Radiosensitivity of Nasopharyngeal Carcinoma through Synergically Promoting Ferroptosis.		circADARB1 	hsa_circ_ADARB1	ADARB1	Nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circADARB1 is upregulated in NPC tissues and is associated with poor overall survival and radiotherapy resistance. Mechanistically, circADARB1 sponges miR-615-5p to increase HSP90B1 expression, which maintains SLC7A11 and GPX4 protein stability after irradiation and suppresses ferroptosis, thereby promoting radioresistance. Targeting circADARB1 with Fe@Pdots-siRNA enhances ferroptosis and radiosensitivity in NPC models."	0.8953
39467212	Journal of biochemical and molecular toxicology	2024	Knockdown of circ_0006225 overcomes resistance to cisplatin and suppresses growth in lung cancer by miR-1236-3p/ANKRD22 axis.	hsa_circ_0006225	Circ_0006225 	hsa_circ_MND1	MND1	lung cancer; cisplatin-resistant lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circ_0006225 is up-regulated in cisplatin-resistant lung cancer tissues and cells. It promotes proliferation, tumor growth and cisplatin resistance by sponging miR-1236-3p to regulate ANKRD22, while circ_0006225 knockdown sensitizes resistant lung cancer cells and xenografts to cisplatin."	0.8295
39471711	Biosensors & bioelectronics	2025	A dual-signal biosensor based on surface-enhanced Raman spectroscopy for high-sensitivity quantitative detection and imaging of circRNA in living cells.		circSATB2 	hsa_circ_SATB2	SATB2	lung cancer 	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"This study used circSATB2 as the target circRNA for a dual-signal SERS biosensor and showed that circSATB2 expression is higher in lung cancer cell lines H1650 and HCC827 than in normal lung epithelial BEAS-2B cells. The work supports circSATB2 as a detectable intracellular biomarker candidate for lung cancer using SERS imaging and RT-PCR, but it does not investigate a disease-driving regulatory mechanism."	0.31
39475972	World journal of urology	2024	Circular RNA circABCC4 as the ceRNA facilitates renal carcinoma progression.		circABCC4e 	hsa_circ_ABCC4	ABCC4	renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR; ISH	"circABCC4e is a human ABCC4-derived circRNA upregulated in RCC tissues, cell lines, plasma and urine, and its levels correlate with advanced tumor stage and decrease after resection. Functionally, circABCC4e promotes RCC cell proliferation, migration, invasion and xenograft growth. Mechanistically, it acts as a ceRNA/miRNA sponge that antagonizes tumor-suppressive miR-101-5p, miR-133-5p and miR-138-5p."	0.8294
39476847	The journal of obstetrics and gynaecology research	2024	ZC3H13-induced the m6A modification of hsa_circ_0081723 promotes cervical cancer progression via AMPK/p53 pathway.	hsa_circ_0081723	hsa_-circ_0081723			cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0081723 is up-regulated in cervical cancer tissues and its high expression is associated with advanced clinicopathological features and poor prognosis. Functionally, it promotes cervical cancer cell proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, ZC3H13-mediated m6A modification increases hsa_circ_0081723 stability, while hsa_circ_0081723 promotes cervical cancer progression by suppressing the AMPK/p53 pathway."	0.8353
39476941	Experimental cell research	2024	"Has_circ_0002360 facilitates immune evasion by enhancing heterogeneous nuclear ribonucleoprotein A1 stability, thereby promoting malignant progression in non-small cell lung cancer."	hsa_circ_0002360		hsa_circ_RUNX1	RUNX1	Non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0002360 is up-regulated in NSCLC tissues and cell lines and is associated with advanced TNM stage and distant metastasis. Functionally, it promotes proliferation, invasion, migration, EMT, tumor growth and immune evasion while suppressing apoptosis. Mechanistically, it interacts with HNRNPA1, enhances HNRNPA1 mRNA stability, and activates PD-L1/TGF-beta-related immune evasion programs."	0.8355
39481837	Life sciences	2024	NRF1-induced mmu_circ_0001388/hsa_circ_0029470 confers ferroptosis resistance in ischemic acute kidney injury via the miR-193b-3p/TCF4/GPX4 axis.	mmu_circ_0001388		mmu_circ_Ep400	Ep400	ischemic acute kidney injury 	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR	"NRF1-induced mmu_circ_0001388 is up-regulated after renal I/R injury and acts protectively in ischemic AKI. It suppresses ferroptosis by sponging miR-193b-3p/miR-139b-3p, increasing TCF4 and GPX4, thereby reducing lipid peroxidation, ROS, Fe2+ accumulation, mitochondrial damage and renal tubular injury."	0.73
39481837	Life sciences	2024	NRF1-induced mmu_circ_0001388/hsa_circ_0029470 confers ferroptosis resistance in ischemic acute kidney injury via the miR-193b-3p/TCF4/GPX4 axis.	hsa_circ_0029470				ischemic acute kidney injury 	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR	"Human hsa_circ_0029470, a homolog of mmu_circ_0001388, is induced after ischemic injury in HK-2 cells. It suppresses I/R-induced ferroptosis through the NRF1/hsa_circ_0029470/miR-193b-3p/TCF4/GPX4 regulatory pathway and is proposed as a potential therapeutic target for ischemic AKI."	0.3957
39486250	"Pathology, research and practice"	2024	Circ_0060927 promotes colorectal cancer development by sponging miR-331-3p and upregulating TBX2.	hsa_circ_0060927	circ_0060927	hsa_circ_CYP24A1	CYP24A1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0060927 is up-regulated in colorectal cancer tissues and cell lines and may serve as a diagnostic biomarker. Functionally, it promotes CRC progression by enhancing proliferation, autophagy, migration, invasion and tumor growth while suppressing apoptosis and necrosis. Mechanistically, circ_0060927 acts as a ceRNA by sponging miR-331-3p, thereby upregulating TBX2."	0.8489
39486700	International journal of biological macromolecules	2024	Circular RNA circWBSCR22 facilitates colorectal cancer metastasis by enhancing CHD4's protein stability.	hsa_circ_0005588	circWBSCR22	hsa_circ_WBSCR22	WBSCR22	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; Microarray	"circWBSCR22 (hsa_circ_0005588) is up-regulated in colorectal cancer tissues and functions as an oncogenic circRNA. It promotes CRC proliferation, migration, invasion, EMT, tumour growth, and metastasis by binding UPF1 and reducing UPF1-mediated ubiquitination degradation of CHD4, thereby stabilizing CHD4 protein. The study proposes circWBSCR22 as a potential diagnostic/prognostic biomarker and therapeutic target for CRC."	0.8817
39488295	Experimental cell research	2024	Methionine restriction promotes cisplatin sensitivity of gastric cancer resistant cells by down-regulating circ-CDK13 level.	hsa_circ_0079929	circ-CDK13	hsa_circ_CDK13	CDK13	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circ-CDK13 (hsa_circ_0079929) is up-regulated in DDP-resistant gastric cancer cells and clinical GC/DDP-resistant samples. Methionine restriction suppresses EIF4A3-mediated circ-CDK13 cyclization, lowering circ-CDK13 and thereby enhancing cisplatin sensitivity, increasing apoptosis, and reducing tumor growth."	0.8001
39488295	Experimental cell research	2024	Methionine restriction promotes cisplatin sensitivity of gastric cancer resistant cells by down-regulating circ-CDK13 level.	hsa_circ_0023984				gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0023984 was identified by GEO-based screening and qRT-PCR as significantly down-regulated in DDP-resistant gastric cancer cell lines, but the study did not further characterize its function or mechanism."	0.1768
39488295	Experimental cell research	2024	Methionine restriction promotes cisplatin sensitivity of gastric cancer resistant cells by down-regulating circ-CDK13 level.	hsa_circ_0004116				gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0004116 was identified by GEO-based screening and qRT-PCR as significantly up-regulated in DDP-resistant gastric cancer cell lines, but the study did not further characterize its function or mechanism."	0.1768
39488295	Experimental cell research	2024	Methionine restriction promotes cisplatin sensitivity of gastric cancer resistant cells by down-regulating circ-CDK13 level.	hsa_circ_0077736				gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0077736 was identified by GEO-based screening and qRT-PCR as significantly up-regulated in DDP-resistant gastric cancer cell lines, but the study did not further characterize its function or mechanism."	0.1768
39488875	Phytomedicine : international journal of phytotherapy and phytopharmacology	2024	The role of METTL3-mediated CircStk4 modification in the treatment of chronic glomerulonephritis with Qi Teng Xiao Zhuo granule.		circStk4 	mmu_circ_Stk4		chronic glomerulonephritis 	MONDO:0002462	glomerulonephritis	up-regulated	RT-qPCR	"In the chronic glomerulonephritis model, circStk4 is up-regulated and is promoted by METTL3-mediated m6A modification. circStk4 acts through the miR-133a-3p/C1 axis to promote mesangial/renal tissue proliferation and suppress apoptosis and autophagy, while QTXZG treatment reduces METTL3, circStk4 m6A modification, and circStk4 expression to alleviate CGN-associated injury."	0.5313
39492301	"Oral surgery, oral medicine, oral pathology and oral radiology"	2023	Circ_0049396 attenuates the progression of oral squamous cell carcinoma by miR-650 suppression to induce neurofilament heavy polypeptide enhancement.	hsa_circ_0049396	circ_0049396			oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR	"circ_0049396 is down-regulated in OSCC tissues and cell lines. Its overexpression suppresses OSCC proliferation, migration, clone formation, and xenograft tumor growth by sponging miR-650 and increasing NEFH expression, supporting a tumor-suppressive role for the circ_0049396/miR-650/NEFH axis."	0.7795
39495350	Molecular biology reports	2024	Clinical significance and potential mechanism of hsa_circ_0006892 in acute respiratory distress syndrome complicated with pulmonary fibrosis.	hsa_circ_0006892	hsa_ circ_0006892 	hsa_circ_PI4KB	PI4KB	acute respiratory distress syndrome 	MONDO:0006502	acute respiratory distress syndrome	down-regulated	RT-qPCR; Microarray	"This study found that serum hsa_circ_0006892 is down-regulated in ARDS patients and further decreased in ARDS patients with PLF. Clinically, it showed diagnostic value for ARDS and predictive value for PLF development, and mechanistically the study proposed a hsa_circ_0006892/miR-486-3p axis linked to Ras signaling and related genes such as SRC, MAPK3 and RELA."	0.6616
39497470	Diabetes/metabolism research and reviews	2024	Differences in Immune Cell-Derived Circular RNA Between Fulminant Type 1 Diabetes and Type 1 Diabetes.		hsa_circRNA_038288	hsa_circ_SMG1	SMG1	fulminant type 1 diabetes 	MONDO:0005147	type 1 diabetes mellitus	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_038288 was down-regulated in PBMCs from FT1D patients compared with T1D patients and was validated by RT-qPCR. The study predicts that it participates in diabetes- and immune regulation-related circRNA-miRNA-mRNA networks, especially a possible hsa_circRNA_038288-hsa-miR-320a-NFAT5 axis, and may also have protein-coding potential."	0.5135
39497470	Diabetes/metabolism research and reviews	2024	Differences in Immune Cell-Derived Circular RNA Between Fulminant Type 1 Diabetes and Type 1 Diabetes.		hsa_circRNA_104405			fulminant type 1 diabetes 	MONDO:0005147	type 1 diabetes mellitus	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_104405 was up-regulated in PBMCs from FT1D patients compared with T1D patients and was validated by RT-qPCR. Bioinformatic prediction indicated miRNA-binding potential, including one miRNA relevant to diabetes and immune regulation."	0.5135
39497470	Diabetes/metabolism research and reviews	2024	Differences in Immune Cell-Derived Circular RNA Between Fulminant Type 1 Diabetes and Type 1 Diabetes.		hsa_circRNA_405498			fulminant type 1 diabetes 	MONDO:0005147	type 1 diabetes mellitus	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_405498 was up-regulated in PBMCs from FT1D patients compared with T1D patients and was validated by RT-qPCR. Bioinformatic prediction indicated miRNA-binding potential, including one miRNA associated with diabetes and immune regulation."	0.5135
39497470	Diabetes/metabolism research and reviews	2024	Differences in Immune Cell-Derived Circular RNA Between Fulminant Type 1 Diabetes and Type 1 Diabetes.		hsa_circRNA_404184			fulminant type 1 diabetes 	MONDO:0005147	type 1 diabetes mellitus	up-regulated	Microarray	hsa_circRNA_404184 was identified by circRNA microarray as up-regulated in PBMCs from FT1D patients compared with T1D patients. The paper did not report successful RT-qPCR validation or a specific mechanism for this circRNA.	0.279
39497470	Diabetes/metabolism research and reviews	2024	Differences in Immune Cell-Derived Circular RNA Between Fulminant Type 1 Diabetes and Type 1 Diabetes.		hsa_circRNA_402803			fulminant type 1 diabetes 	MONDO:0005147	type 1 diabetes mellitus	down-regulated	Microarray	hsa_circRNA_402803 was identified by circRNA microarray as down-regulated in PBMCs from FT1D patients compared with T1D patients. The paper did not report successful RT-qPCR validation or a specific mechanism for this circRNA.	0.279
39497470	Diabetes/metabolism research and reviews	2024	Differences in Immune Cell-Derived Circular RNA Between Fulminant Type 1 Diabetes and Type 1 Diabetes.		hsa_circRNA_000178			fulminant type 1 diabetes 	MONDO:0005147	type 1 diabetes mellitus	down-regulated	Microarray	hsa_circRNA_000178 was identified by circRNA microarray as down-regulated in PBMCs from FT1D patients compared with T1D patients. The paper did not report successful RT-qPCR validation or a specific mechanism for this circRNA.	0.279
39497470	Diabetes/metabolism research and reviews	2024	Differences in Immune Cell-Derived Circular RNA Between Fulminant Type 1 Diabetes and Type 1 Diabetes.		hsa_circRNA_001510			fulminant type 1 diabetes 	MONDO:0005147	type 1 diabetes mellitus	dysregulated	RT-qPCR; Microarray	"hsa_circRNA_001510 was identified by microarray as down-regulated in FT1D relative to T1D, while RT-qPCR showed higher expression in FT1D patients than controls. No specific molecular mechanism was reported for this circRNA."	0.4773
39499344	Functional & integrative genomics	2024	Circular RNA circ_0022707 impedes the progression of preeclampsia via the miR-3135b/GHR/PI3K/Akt axis.	hsa_circ_0022707	circ_0022707 	hsa_circ_MAP4K2	MAP4K2	Preeclampsia 	MONDO:0005081	preeclampsia	down-regulated	RT-qPCR; Microarray	"circ_0022707 is downregulated in PE placentas and its lower expression correlates with more severe PE-related clinical indicators. Functionally, circ_0022707 promotes trophoblast proliferation and cell cycle progression while inhibiting apoptosis, and it alleviates preeclampsia-like manifestations in L-NAME-induced mice. Mechanistically, it acts through the miR-3135b/GHR/PI3K/Akt axis."	0.8458
39499388	Molecular biotechnology	2025	Hsa_circ_0109320 Serves as a Novel Circular RNA Biomarker in Non-small Cell Lung Cancer by Promoting Metastasis.	hsa_circ_0109320				Non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"This study found that circ_0109320 is up-regulated in NSCLC/lung cancer tissues, metastatic lymph nodes, and NSCLC cell lines. Functionally, circ_0109320 promotes migration, invasion and EMT progression but did not affect proliferation in A549 and SK-MES-1 cells. Clinically, circ_0109320 showed biomarker potential for distinguishing tumor and metastatic lymph node samples and was associated with lymph node metastasis."	0.716
39503793	Genetic testing and molecular biomarkers	2024	"Immune Regulatory Circular RNAs, circRasGEF1B and circHIPK3, are Upregulated in Peripheral Blood Mononuclear Cells of COVID-19 Patients."	hsa_circ_0127052	circRasGEF1B 	hsa_circ_GEF1B	GEF1B	COVID-19 	MONDO:0100096	COVID-19	up-regulated	RT-qPCR	"circRasGEF1B (hsa_circ_0127052) was significantly upregulated in PBMCs from COVID-19 patients compared with healthy controls. The study supports its potential use as a diagnostic biomarker for COVID-19, but did not experimentally validate a molecular mechanism."	0.4187
39503793	Genetic testing and molecular biomarkers	2024	"Immune Regulatory Circular RNAs, circRasGEF1B and circHIPK3, are Upregulated in Peripheral Blood Mononuclear Cells of COVID-19 Patients."	hsa_circ_0008887	circHIPK3 	hsa_circ_HIPK3	HIPK3	COVID-19 	MONDO:0100096	COVID-19	up-regulated	RT-qPCR	"circHIPK3/circRNA100783 was significantly upregulated in PBMCs from COVID-19 patients compared with healthy controls. The study suggests it may participate in immune responses to viral infection and may serve as a COVID-19 diagnostic biomarker, although no functional mechanism was experimentally tested."	0.4187
39527456	"Shock (Augusta, Ga.)"	2025	CIRC_0068655 SILENCING AMELIORATES HYPOXIA-INDUCED HUMAN CARDIOMYOCYTE INJURY BY REGULATING APOPTOTIC AND INFLAMMATORY RESPONSES.	hsa_circ_0068655	CIRC_0068655 	hsa_circ_UBXN7	UBXN7	myocardial ischemia/reperfusion injury 	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR	"hsa_circ_0068655 is up-regulated in hypoxia-treated human AC16 cardiomyocytes. It promotes hypoxia-induced cardiomyocyte injury by sponging miR-370-3p, thereby relieving repression of BCL2L11 and enhancing apoptosis and inflammatory responses while suppressing proliferation. Silencing circ_0068655 shows a protective effect in this in vitro myocardial ischemia model."	0.7626
39544800	American journal of translational research	2024	Serum hsa_circ_0007534 as a diagnostic biomarker for ovarian cancer.	hsa_circ_0007534				ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"This clinical study found that serum hsa_circ_0007534 is up-regulated in ovarian cancer patients and is also higher in OC tissues than adjacent non-cancerous tissues. Elevated serum hsa_circ_0007534 is associated with aggressive clinicopathologic features, poorer OS/PFS, and chemoresistance, supporting its potential as a diagnostic and prognostic circulating biomarker. The study did not investigate the molecular mechanism of hsa_circ_0007534 in OC."	0.4992
39546192	Tissue engineering and regenerative medicine	2025	Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying Circ-Tulp4 Attenuate Diabetes Mellitus with Nonalcoholic Fatty Liver Disease by Inhibiting Cell Pyroptosis through the HNRNPC/ABHD6 Axis.		circ-Tulp4	mmu_circ_Tulp4	Tulp4	Diabetes mellitus with nonalcoholic fatty liver disease 	MONDO:0005015	diabetes mellitus	down-regulated	RT-qPCR	"circ-Tulp4 is reduced in DM-NAFLD models and can be delivered into hepatocytes by UCMSCs-derived extracellular vesicles. Restored or elevated circ-Tulp4 binds KDM6B, promotes H3K27me3 enrichment at the HNRNPC promoter, suppresses the HNRNPC/ABHD6 axis, inhibits the NLRP3/cleaved Caspase-1/GSDMD-N pyroptosis pathway, and alleviates hepatic steatosis and DM-NAFLD progression."	0.7215
39549296	"Iranian journal of allergy, asthma, and immunology"	2024	Synergistic Treatment Approach for Pulmonary Fibrosis: Prednisone and Cyclophosphamide Regulation of Circular RNA MORF4L1 and MicroRNA-29a-3p Targeting BRD4.		circular RNA mortality factor 4 like 1 (MORF4L1) 	rno_circ_MORF4L1	MORF4L1	pulmonary fibrosis 	MONDO:0002771	pulmonary fibrosis	up-regulated	RT-qPCR	"In bleomycin-induced rat pulmonary fibrosis, circRNA MORF4L1 is upregulated and appears to promote fibrosis-related marker expression and lung-cell apoptosis. Prednisone combined with cyclophosphamide alleviates PF partly by downregulating MORF4L1, which enhances miR-29a-3p-mediated repression of BRD4."	0.5627
39549466	Journal of neuroimmunology	2024	Silencing of circular RNA PTP4A2 ameliorates depressive-like behaviors by inhibiting microglia activation in mice.		Circular RNA PTP4A2 	mmu_circ_PTP4A2	PTP4A2	Major depressive disorder 	MONDO:0002009	major depressive disorder	up-regulated	RT-qPCR	"In the CUS mouse model of depressive-like behaviors, circPTP4A2 is up-regulated in the hippocampus and peripheral blood. Silencing circPTP4A2 ameliorates depressive-like behaviors and reduces microglia activation and inflammatory responses, likely by inhibiting P38 phosphorylation in the MAPK pathway."	0.414
39549809	International journal of biological macromolecules	2024	circAGO3 facilitates NF-kappaB pathway-mediated inflammatory atrophy in chicken skeletal muscle via the miR-34b-5p/TRAF3 axis.		circAGO3	gga_circ_AGO3	AGO3	skeletal muscle atrophy 	MONDO:0005583	non-human animal disease	up-regulated	RT-qPCR; RNA-seq	"circAGO3 is a chicken AGO3-derived circRNA that is highly expressed in muscle tissues and inversely correlated with breast muscle development. Its overexpression inhibits myogenic differentiation, promotes skeletal muscle and myotube atrophy, and enhances inflammatory responses by sponging miR-34b-5p to upregulate TRAF3 and activate NF-kappaB signaling."	0.7541
39549823	Cellular signalling	2025	N6-methyladenosine-modified circRPS6KC1 regulated cellular senescence in prostate cancer via FOXM1/PCNA axis.	hsa_circ_0005522	circRPS6KC1	hsa_circ_RPS6KC1	RPS6KC1	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; RNA-seq; Microarray	"circRPS6KC1 is an up-regulated human circRNA in prostate cancer derived from RPS6KC1. METTL3/YTHDF1-mediated m6A modification stabilizes circRPS6KC1, and circRPS6KC1 promotes proliferation and suppresses cellular senescence by sponging miR-761 to regulate FOXM1. FOXM1 then regulates PCNA transcription and p21 protein degradation in a p53-independent pathway."	0.8872
39555732	Journal of biochemical and molecular toxicology	2024	Identification of the Oncogenic Role of the Circ_0001326/miR-577/VDAC1 Cascade in Prostate Cancer.	hsa_circ_0001326	circ_0001326	hsa_circ_PHLDB2	PHLDB2	Prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"Circ_0001326 is up-regulated in prostate cancer tissues and cell lines and acts as an oncogenic circRNA. Its knockdown suppresses proliferation, colony formation, migration, invasion and xenograft tumor growth while promoting apoptosis. Mechanistically, circ_0001326 sponges miR-577 to relieve repression of VDAC1, forming a circ_0001326/miR-577/VDAC1 regulatory cascade."	0.8175
39556429	Neoplasma	2024	"EIF4A3-induced circle RNA_ 0001860 promotes growth, invasion, and immune evasion of gastric cancer cells through the miR-618/HMGA2 axis."	hsa_circ_0001860	Circle RNA_ 0001860 	hsa_circ_ZCCHC7	ZCCHC7	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_0001860 is upregulated in gastric cancer tissues and cell lines and is associated with shorter overall survival and more aggressive clinicopathological features. EIF4A3 induces circ_0001860 expression, and circ_0001860 promotes gastric cancer growth, invasion, and immune evasion by sponging miR-618 to increase HMGA2 expression. Silencing circ_0001860 suppresses malignant phenotypes in vitro and reduces xenograft tumor growth in vivo."	0.8066
39560876	Neurochemical research	2024	Alterations in Circular RNAs circOprm1 and circSerpini in the Striatum are Associated with Changes in Spatial Working Memory Performance after Morphine Dependence and Withdrawal in Rats.		circOprm1	rno_circ_Oprm1	Oprm1	morphine dependence and withdrawal 	MONDO:0005531	morphine dependence	down-regulated	RT-qPCR	"In rat striatum, circOprm1 was significantly down-regulated after morphine dependence and recovered after 30 days of withdrawal. Its altered expression was associated with OPRM1 up-regulation and spatial working memory changes, but the authors did not confirm a circOprm1-mediated miR-339-3p sponging mechanism."	0.4712
39560876	Neurochemical research	2024	Alterations in Circular RNAs circOprm1 and circSerpini in the Striatum are Associated with Changes in Spatial Working Memory Performance after Morphine Dependence and Withdrawal in Rats.		circSerpini 	rno_circ_Serpini1	Serpini1	morphine dependence and withdrawal 	MONDO:0005531	morphine dependence	up-regulated	RT-qPCR	"In rat striatum, circSerpini was significantly up-regulated after morphine dependence and remained above baseline after withdrawal. The study links circSerpini changes with Serpini1, miR-181 family members, TLR4 expression, and spatial working memory alterations, while noting that miR-181-mediated inhibition was not confirmed and other miRNAs may be involved."	0.4712
39566705	Bone	2025	The functions and clinical implications of hsa_circ_0032462-miR-488-3p-SLC7A1 axis in human osteosarcoma.	hsa_circ_0032462				osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0032462 is up-regulated in osteosarcoma tissues and cells. It promotes OS cell viability, migration, invasion, and disease progression through a ceRNA axis involving miR-488-3p and SLC7A1, and high expression is associated with poor overall survival."	0.7624
39566705	Bone	2025	The functions and clinical implications of hsa_circ_0032462-miR-488-3p-SLC7A1 axis in human osteosarcoma.	hsa_circ_0004771				osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	Microarray	"hsa_circ_0004771 was identified from public microarray datasets as a down-regulated circRNA in osteosarcoma. It was included in the predicted OS circRNA/miRNA/mRNA ceRNA network, but no circRNA-specific experimental validation or clinical survival analysis was reported for it."	0.1768
39566705	Bone	2025	The functions and clinical implications of hsa_circ_0032462-miR-488-3p-SLC7A1 axis in human osteosarcoma.	hsa_circ_0007277		hsa_circ_DCAF6	DCAF6	osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	Microarray	"hsa_circ_0007277 was identified from public microarray datasets as a down-regulated circRNA in osteosarcoma. It was included in the predicted OS circRNA/miRNA/mRNA ceRNA network, but no circRNA-specific experimental validation or clinical survival analysis was reported for it."	0.1768
39566705	Bone	2025	The functions and clinical implications of hsa_circ_0032462-miR-488-3p-SLC7A1 axis in human osteosarcoma.	hsa_circ_0027493				osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	Microarray	"hsa_circ_0027493 was identified from public microarray datasets as a down-regulated circRNA in osteosarcoma. It was included in the predicted OS circRNA/miRNA/mRNA ceRNA network, but no circRNA-specific experimental validation or clinical survival analysis was reported for it."	0.1768
39566705	Bone	2025	The functions and clinical implications of hsa_circ_0032462-miR-488-3p-SLC7A1 axis in human osteosarcoma.	hsa_circ_0061274				osteosarcoma 	MONDO:0009807	osteosarcoma	down-regulated	Microarray	"hsa_circ_0061274 was identified from public microarray datasets as a down-regulated circRNA in osteosarcoma. It was included in the predicted OS circRNA/miRNA/mRNA ceRNA network, but no circRNA-specific experimental validation or clinical survival analysis was reported for it."	0.1768
39575501	"American journal of reproductive immunology (New York, N.Y. : 1989)"	2024	Circ-ADAM9 Knockdown Reduces Insulin Resistance and Placental Injury in Diabetic Mice via MAPK Pathway Inactivation.		circ-ADAM9	hsa_circ_ADAM9	ADAM9	Gestational diabetes mellitus 	MONDO:0005406	gestational diabetes	up-regulated	RT-qPCR; Microarray	"circ-ADAM9 is up-regulated in GDM patient blood, GDM mice, and HG-induced trophoblast cells. Its knockdown alleviates insulin resistance, lipid metabolic abnormalities, placental apoptosis, oxidative stress, and fetal impairment. Mechanistically, circ-ADAM9 sponges miR-375 to increase FPR2 expression and activate MAPK signaling, making it a potential therapeutic target for GDM."	0.8279
39575501	"American journal of reproductive immunology (New York, N.Y. : 1989)"	2024	Circ-ADAM9 Knockdown Reduces Insulin Resistance and Placental Injury in Diabetic Mice via MAPK Pathway Inactivation.			mmu_circ_Adam9	Adam9	Gestational diabetes mellitus 	MONDO:0005406	gestational diabetes	up-regulated	RT-qPCR; Microarray	"circ-ADAM9 is up-regulated in GDM patient blood, GDM mice, and HG-induced trophoblast cells. Its knockdown alleviates insulin resistance, lipid metabolic abnormalities, placental apoptosis, oxidative stress, and fetal impairment. Mechanistically, circ-ADAM9 sponges miR-375 to increase FPR2 expression and activate MAPK signaling, making it a potential therapeutic target for GDM."	0.8279
39581359	Cellular signalling	2025	Inhibitory effects of circR-127aa on gastric cancer progression and tumor growth.	hsa_circ_0075402	circRACK1 	hsa_circ_RACK1	RACK1	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"hsa_circ_0075402/circRACK1 is down-regulated in gastric cancer cells and encodes the tumor-suppressive peptide circR-127aa. circR-127aa interacts with Vimentin and ACTIN, promotes Vimentin ubiquitination and proteasomal degradation, and inhibits proliferation, migration, invasion, angiogenesis, EMT, tumor growth and metastasis while promoting apoptosis."	0.8189
39586158	Archives of gerontology and geriatrics	2025	CircRSU1 contributes to the development of osteoarthritis via the miR-345-3p/TRAF6 signaling.		circRSU1	hsa_circ_RSU1	RSU1	osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circRSU1 is up-regulated in osteoarthritis specimens and in IL-1beta-treated human chondrocytes. Functional experiments showed that circRSU1 knockdown attenuates IL-1beta-induced chondrocyte dysfunction by restoring proliferation and reducing apoptosis, ECM degradation and inflammatory cytokine production. Mechanistically, circRSU1 regulates the miR-345-3p/TRAF6 signaling axis in OA progression."	0.6521
39586520	Cellular signalling	2025	CircINADL promotes nasopharyngeal carcinoma metastasis by inhibiting HuR ubiquitin degradation and disrupting the hippo signaling pathway.		circINADL 	hsa_circ_INADL	INADL	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"circINADL is a novel INADL-derived circRNA upregulated in NPC tissues and cell lines, and its high expression correlates with advanced clinical stage and poor survival. FUS promotes circINADL generation, while circINADL binds HuR, blocks beta-TrCP-mediated HuR ubiquitination and degradation, stabilizes YAP1 mRNA, disrupts Hippo/YAP signaling, and promotes NPC migration, invasion, EMT, and metastasis."	0.894
39587404	Experimental lung research	2024	"Whole transcriptome sequencing identifies key lncRNAs, circRNAs and miRNAs in sepsis-associated acute lung injury."		circRNA-Jmjdlc	mmu_circ_Jmjdlc	Jmjdlc	sepsis-associated acute lung injury 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR; RNA-seq	"circRNA-Jmjdlc was identified as an up-regulated mouse circRNA in LPS-induced sepsis-associated ALI. It was included in a predicted circRNA-miRNA-mRNA ceRNA subnetwork and was predicted to bind miR-351-5p, but it was not expressed in humans, limiting its translational relevance."	0.4851
39587404	Experimental lung research	2024	"Whole transcriptome sequencing identifies key lncRNAs, circRNAs and miRNAs in sepsis-associated acute lung injury."		circRNA-Tcf20	hsa_circ_TCF20	Tcf20	sepsis-associated acute lung injury 	MONDO:0005229	bacterial infectious disease with sepsis	down-regulated	RT-qPCR; RNA-seq	"circRNA-Tcf20 was identified as a down-regulated circRNA in LPS-induced sepsis-associated ALI and was also down-regulated in BALF from sepsis-associated ARDS patients. It was predicted to interact with miR-212-3p and miR-223-3p and was linked to coexpressed mRNAs including Col1a1, Col1a2 and Flt3, with enrichment in the PI3K-Akt signaling pathway. The study proposes circRNA-Tcf20 as a potential regulatory factor and biomarker for septic ALI/ARDS."	0.5922
39587404	Experimental lung research	2024	"Whole transcriptome sequencing identifies key lncRNAs, circRNAs and miRNAs in sepsis-associated acute lung injury."		circRNA-Tcf20	mmu_circ_Tcf20	Tcf20	sepsis-associated acute lung injury 	MONDO:0005229	bacterial infectious disease with sepsis	down-regulated	RT-qPCR; RNA-seq	"circRNA-Tcf20 was identified as a down-regulated circRNA in LPS-induced sepsis-associated ALI and was also down-regulated in BALF from sepsis-associated ARDS patients. It was predicted to interact with miR-212-3p and miR-223-3p and was linked to coexpressed mRNAs including Col1a1, Col1a2 and Flt3, with enrichment in the PI3K-Akt signaling pathway. The study proposes circRNA-Tcf20 as a potential regulatory factor and biomarker for septic ALI/ARDS."	0.5922
39587803	Journal of cellular biochemistry	2025	Circ-ECH1 May Compete With miR-708-5p to Regulate Ntrk2 in Bronchopulmonary Dysplasia.		circ-ECH1 	rno_circ_ECH1	ECH1	Bronchopulmonary dysplasia 	MONDO:0019091	bronchopulmonary dysplasia	down-regulated	RT-qPCR	"Circ-ECH1 is down-regulated in hyperoxia-induced BPD models. Its overexpression protects against BPD-like injury by increasing L2 cell viability, reducing apoptosis and ROS accumulation, and alleviating pulmonary fibrosis and lung apoptosis. Mechanistically, circ-ECH1 may act as a ceRNA for miR-708-5p to regulate Ntrk2 expression."	0.7534
39587911	Histology and histopathology	2025	Hsa_circ_0088036 promotes tumorigenesis and chemotherapy resistance in hepatocellular carcinoma via the miR-140-3p/KIF2A axis.	hsa_circ_0088036	circ_0088036	hsa_circ_SUSD1	SUSD1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"hsa_circ_0088036 is up-regulated in HCC tissues and cells and is even higher in oxaliplatin-resistant cells. It promotes HCC proliferation, invasion, tumor growth, and chemotherapy resistance by binding miR-140-3p, increasing KIF2A expression, and activating PI3K/Akt and Notch signaling, suggesting potential as a therapeutic target for chemotherapy-resistant HCC."	0.8005
39588760	Journal of biochemical and molecular toxicology	2024	Mechanisms of METTL14-Mediated m6A Modification in Promoting Iron Overload-Induced Lipid Peroxidative Damage in Vascular Endothelial Cells to Aggravate Atherosclerosis.			mmu_circ_Arhgap12	Arhgap12	Atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"circARHGAP12 is up-regulated in atherosclerotic tissues and ox-LDL-treated HUVECs. METTL14-mediated m6A modification increases circARHGAP12 stability, and circARHGAP12 binds HuR to stabilize ASPH mRNA, promoting ASPH transcription and aggravating iron overload-related lipid peroxidative damage, apoptosis, and AS progression."	0.7394
39588760	Journal of biochemical and molecular toxicology	2024	Mechanisms of METTL14-Mediated m6A Modification in Promoting Iron Overload-Induced Lipid Peroxidative Damage in Vascular Endothelial Cells to Aggravate Atherosclerosis.			hsa_circ_ARHGAP12 	ARHGAP12 	Atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"circARHGAP12 is up-regulated in atherosclerotic tissues and ox-LDL-treated HUVECs. METTL14-mediated m6A modification increases circARHGAP12 stability, and circARHGAP12 binds HuR to stabilize ASPH mRNA, promoting ASPH transcription and aggravating iron overload-related lipid peroxidative damage, apoptosis, and AS progression."	0.7394
39589641	Veterinary research communications	2024	Identification of potential key circular RNAs associated with Escherichia coli-infected bovine mastitis using RNA-sequencing: preliminary study results.		novel_circRNA_0000128 	bta_circ_APC	APC	Escherichia coli-infected bovine mastitis 	MONDO:0025100	"mastitis, bovine"	up-regulated	RT-qPCR; RNA-seq	"novel_circ_0000128 was identified as an up-regulated circRNA in E. coli-infected bovine mastitis and was validated by RT-qPCR. Its source gene APC suggests possible involvement in anti-inflammatory, anti-apoptotic and cell-protective processes, and the study predicts that this circRNA may participate in circRNA-miRNA regulatory networks in mastitis."	0.3684
39589641	Veterinary research communications	2024	Identification of potential key circular RNAs associated with Escherichia coli-infected bovine mastitis using RNA-sequencing: preliminary study results.		novel_circRNA_0011103 	bta_circ_USP7	USP7	Escherichia coli-infected bovine mastitis 	MONDO:0025100	"mastitis, bovine"	up-regulated	RT-qPCR; RNA-seq	"novel_circ_0011103 was identified as an up-regulated and RT-qPCR-validated circRNA in E. coli-infected bovine mastitis. The authors suggest that its source gene USP7, an NF-kappaB transcriptional activity regulator, may connect this circRNA to inflammation and immunity in mastitis."	0.3684
39589641	Veterinary research communications	2024	Identification of potential key circular RNAs associated with Escherichia coli-infected bovine mastitis using RNA-sequencing: preliminary study results.		novel_circRNA_0012656 	bta_circ_CYFIP1	CYFIP1	Escherichia coli-infected bovine mastitis 	MONDO:0025100	"mastitis, bovine"	up-regulated	RT-qPCR; RNA-seq	"novel_circ_0012656 was up-regulated in E. coli-infected bovine mastitis and validated by RT-qPCR. Its source gene CYFIP1 is linked by the authors to MyD88-dependent inflammation and phagocytosis, supporting a possible role in mastitis development and immune response."	0.3684
39589641	Veterinary research communications	2024	Identification of potential key circular RNAs associated with Escherichia coli-infected bovine mastitis using RNA-sequencing: preliminary study results.		novel_circRNA_0015099 	bta_circ_CD36	CD36	Escherichia coli-infected bovine mastitis 	MONDO:0025100	"mastitis, bovine"	down-regulated	RT-qPCR; RNA-seq	"novel_circ_0015099 was down-regulated in E. coli-infected bovine mastitis and validated by RT-qPCR. The authors identify it as a candidate mastitis-regulating circRNA, potentially related to inflammatory response through its source gene CD36 and predicted circRNA-miRNA interactions."	0.3684
39589641	Veterinary research communications	2024	Identification of potential key circular RNAs associated with Escherichia coli-infected bovine mastitis using RNA-sequencing: preliminary study results.		novel_circRNA_005648 	bta_circ_SLC15A4	SLC15A4	Escherichia coli-infected bovine mastitis 	MONDO:0025100	"mastitis, bovine"	down-regulated	RT-qPCR; RNA-seq	"novel_circ_0005648 was down-regulated in E. coli-infected bovine mastitis and validated by RT-qPCR. The authors propose that its source gene SLC15A4 links it to inflammatory diseases and endosomal signal transduction, and it is included in the predicted circRNA-miRNA network."	0.3684
39589641	Veterinary research communications	2024	Identification of potential key circular RNAs associated with Escherichia coli-infected bovine mastitis using RNA-sequencing: preliminary study results.		novel_circRNA_000074 	bta_circ_HOMER1	HOMER1	Escherichia coli-infected bovine mastitis 	MONDO:0025100	"mastitis, bovine"	down-regulated	RT-qPCR; RNA-seq	"novel_circ_0000074 was down-regulated in E. coli-infected bovine mastitis and validated by RT-qPCR. The authors speculate that it may be related to mastitis because its source gene HOMER1 can indirectly regulate AMPK phosphorylation, a process connected to inflammatory response."	0.3684
39589641	Veterinary research communications	2024	Identification of potential key circular RNAs associated with Escherichia coli-infected bovine mastitis using RNA-sequencing: preliminary study results.		novel_circRNA_0011796 	bta_circ_PSD3	PSD3	Escherichia coli-infected bovine mastitis 	MONDO:0025100	"mastitis, bovine"	down-regulated	RT-qPCR; RNA-seq	"novel_circ_0011796 was down-regulated in E. coli-infected bovine mastitis and validated by RT-qPCR. The study identifies it as a candidate mastitis-related circRNA and predicts participation in circRNA-miRNA regulatory interactions, while its specific mechanism remains unresolved."	0.3684
39592557	Molecular neurobiology	2025	High Expression of SMN circ4-2b-3 in SMA I Children Treated with Nusinersen is Associated with Improved Motor Outcomes.		SMN circ4-2b-3	hsa_circ_SMN	SMN locus	spinal muscular atrophy 	MONDO:0001516	spinal muscular atrophy	dysregulated	RT-qPCR	"SMN circ4-2b-3 is an exosome-associated circRNA produced by the human SMN locus and detectable in serum-derived and CSF-derived exosomes. In this study, high SMN circ4-2b-3 copy number was restricted to a subgroup of type I SMA patients with super-responder status after Nusinersen treatment, suggesting potential value as a circulating biomarker of therapeutic response."	0.6291
39601204	Journal of biochemical and molecular toxicology	2024	Circular RNA circ_0004630 promotes malignancy and glycolysis of nonsmall cell lung cancer by sponging microRNA-1208 and regulating leucine-rich repeat kinase 2 expression.	hsa_circ_0004630	hsa_circ_100549 			nonsmall cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0004630 is up-regulated in NSCLC tissues and cell lines, and high expression is associated with poorer survival. Functional knockdown experiments indicate that circ_0004630 promotes NSCLC proliferation, invasion, tumor growth, and glycolysis while suppressing apoptosis. Mechanistically, cytoplasmic circ_0004630 acts as a miR-1208 sponge to upregulate LRRK2."	0.8557
39602957	International immunopharmacology	2025	Transcription factor MAFK binds to circRPPH to regulate SIRT gene-mediated cellular pyroptosis and lung adenocarcinoma progression.	hsa_circ_0000515	circ_000585 	hsa_circ_RPPH1	RPPH1	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circRPPH1/hsa_circ_0000515 is up-regulated in LUAD and high expression is linked to poor survival and metastasis-related clinical features. Mechanistically, nuclear circRPPH1 binds MAFK to enhance SIRT1 transcription/expression, suppressing cellular pyroptosis and promoting LUAD cell growth in vitro and in xenograft models."	0.8981
39602957	International immunopharmacology	2025	Transcription factor MAFK binds to circRPPH to regulate SIRT gene-mediated cellular pyroptosis and lung adenocarcinoma progression.	hsa_circ_0000518				lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000518 was evaluated as a candidate circRNA in LUAD tissues and was found to be significantly overexpressed in LUAD samples. The paper did not report further mechanistic, functional, or prognostic validation for this circRNA."	0.4032
39612069	Journal of molecular histology	2024	CircKRT75 augments the cisplatin chemoresistance of nasopharyngeal carcinoma via targeting miR-659/CCAR2 axis.	hsa_circ_0026387	circKRT75	hsa_circ_KRT75	KRT75	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; Microarray	"circKRT75 is up-regulated in NPC tissues, NPC cell lines, and cisplatin-resistant NPC cells. It promotes cisplatin chemoresistance and malignant growth while suppressing apoptosis through a ceRNA mechanism involving miR-659 and CCAR2. Silencing circKRT75 sensitizes NPC-resistant cells to cisplatin in vitro and suppresses xenograft tumor growth under cisplatin treatment in vivo."	0.8252
39615866	European journal of pharmacology	2025	Identification of hsa_circ_0076957 and miR-4512-targeted COL19A1 as regulators in clopidogrel resistance among stable coronary heart disease patients through comprehensive circRNA and miRNA analysis.	hsa_circ_0076837	hsa_-circ_0076837			clopidogrel resistance 	MONDO:0005010	coronary artery disorder	down-regulated	RT-qPCR; Microarray	"hsa_circ_0076837 was identified as one of the top differentially expressed circRNAs and was downregulated in clopidogrel-resistant SCAD patients. It was linked to DST through the study's target analysis, but no detailed mechanistic validation was reported."	0.5047
39615866	European journal of pharmacology	2025	Identification of hsa_circ_0076957 and miR-4512-targeted COL19A1 as regulators in clopidogrel resistance among stable coronary heart disease patients through comprehensive circRNA and miRNA analysis.	hsa_circ_0057714	hsa_-circ_0057714 			clopidogrel resistance 	MONDO:0005010	coronary artery disorder	down-regulated	RT-qPCR; Microarray	"hsa_circ_0057714 was downregulated in clopidogrel-resistant SCAD patients and was identified as a potential diagnostic biomarker of CR. The study associated it with AOX1, but did not experimentally validate a detailed circRNA-miRNA-mRNA mechanism for this circRNA."	0.5047
39615866	European journal of pharmacology	2025	Identification of hsa_circ_0076957 and miR-4512-targeted COL19A1 as regulators in clopidogrel resistance among stable coronary heart disease patients through comprehensive circRNA and miRNA analysis.	hsa_circ_0085351				clopidogrel resistance 	MONDO:0005010	coronary artery disorder	dysregulated	Microarray	hsa_circ_0085351 was selected among the top differentially expressed circRNAs in the CR versus NCR comparison and was linked to CSMD3 by target analysis. The article did not report a validated expression direction or functional mechanism for this circRNA.	0.348
39615866	European journal of pharmacology	2025	Identification of hsa_circ_0076957 and miR-4512-targeted COL19A1 as regulators in clopidogrel resistance among stable coronary heart disease patients through comprehensive circRNA and miRNA analysis.	hsa_circ_0076957	circ_007695 			clopidogrel resistance 	MONDO:0005010	coronary artery disorder	down-regulated	RT-qPCR; Microarray	"hsa_circ_0076957 was downregulated in CR patients and was identified as a potential diagnostic biomarker. Mechanistically, circ-0076957 was shown in THLE-2 cells to regulate COL19A1 expression through miR-4512, linking it to clopidogrel response regulation."	0.5849
39615866	European journal of pharmacology	2025	Identification of hsa_circ_0076957 and miR-4512-targeted COL19A1 as regulators in clopidogrel resistance among stable coronary heart disease patients through comprehensive circRNA and miRNA analysis.		hsa-circRNA11272-2			clopidogrel resistance 	MONDO:0005010	coronary artery disorder	dysregulated	Microarray	hsa-circRNA11272-2 was selected among the top differentially expressed circRNAs in the CR versus NCR comparison and was linked to SPATA22 by target analysis. The article did not report a validated expression direction or functional mechanism for this circRNA.	0.348
39620326	"Endocrine, metabolic & immune disorders drug targets"	2025	Comprehensive Analysis of circRNA and mRNA Revealing Potential Mechanism Underlying Neuroinflammation in BV2 Cells.	mmu_circ_0010164	chr2:72800499-72801858- 			glucose-induced neuroinflammation 	MONDO:0004466	neuronitis	up-regulated	RT-qPCR; RNA-seq	"mmu_circ_0010164 is up-regulated in glucose- and insulin-induced BV2 microglial neuroinflammation. Its knockdown suppresses inflammatory cytokine responses, and the proposed mechanism involves ceRNA networks with mmu-miR-7043-3p/Gng4 and mmu-miR-6918-3p/Mterf1b."	0.5079
39620326	"Endocrine, metabolic & immune disorders drug targets"	2025	Comprehensive Analysis of circRNA and mRNA Revealing Potential Mechanism Underlying Neuroinflammation in BV2 Cells.		chr17:40159331-40159711+			glucose-induced neuroinflammation 	MONDO:0004466	neuronitis	up-regulated	RT-qPCR; RNA-seq	"chr17:40159331-40159711+ is up-regulated in both glucose- and insulin-treated BV2 cells. The study performed predicted ceRNA network analysis for this circRNA, but did not report functional knockdown or specific validated downstream partners for it."	0.329
39620395	Molecular carcinogenesis	2025	circEIF3I Promotes Colorectal Cancer Metastasis by Regulating the miR-328-3p/NCAPH Axis.	hsa_circ_0011385	circEIF3I 	hsa_circ_EIF3I	EIF3I	Colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circEIF3I is up-regulated in colorectal cancer tissues and cell lines and correlates with tumor size and metastasis. It promotes CRC migration, invasion, EMT, and liver/lung metastasis by sponging miR-328-3p to enhance NCAPH expression, suggesting the circEIF3I/miR-328-3p/NCAPH axis as a potential therapeutic target."	0.7785
39621144	Biochemical genetics	2025	Circ_0000972 Inhibits Hepatocellular Carcinoma Cell Stemness by Targeting miR-96-5p/PFN1.	hsa_circ_0000972	circ_0000972			hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"circ_0000972 is downregulated in HCC tissues and cells and functions as a tumor-suppressive circRNA. It suppresses HCC cancer stem cell colony formation, sphere formation, EMT, migration, invasion, and xenograft tumor growth by sponging miR-96-5p and promoting PFN1 expression."	0.6521
39623910	DNA and cell biology	2025	METTL3-Induced m6A Modification Enhances Hsa_Circ_0136959 Expression to Impair the Tumor Characteristics of Papillary Thyroid Carcinoma via Accelerating Ferroptosis.	hsa_circ_0136959		hsa_circ_CSPP1	CSPP1	papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0136959 is downregulated in papillary thyroid cancer tissues and cell lines. Its overexpression suppresses PTC cell proliferation, migration, and invasion and promotes ferroptosis. METTL3 increases hsa_circ_0136959 expression through m6A modification, supporting a tumor-suppressive METTL3/hsa_circ_0136959/ferroptosis mechanism."	0.7519
39626448	Phytomedicine : international journal of phytotherapy and phytopharmacology	2025	Exploring the mechanism of Taohong Siwu Decoction in treating ischemic stroke injury via the circDnajc1/miR-27a-5p/C1qc signaling axis.		circDnajc1	rno_circ_Dnajc1	Dnajc1	ischemic stroke 	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR	"circDnajc1 is up-regulated in rat MCAO/R and OGD/R ischemic injury models. The study proposes that circDnajc1 functions as a ceRNA for miR-27a-5p to increase C1qc and activate the C1qc/C3/C5aR complement pathway, thereby promoting inflammation, microglial activation, and neuronal apoptosis; THSWD counteracts this axis."	0.4546
39630038	Critical reviews in eukaryotic gene expression	2025	Exosomal circ_001860 Promotes Colorectal Cancer Progression through the miR-582-5p/ZEB1 Axis.		circ_001860			colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"Exosomal circ_001860 is up-regulated in serum/plasma-derived exosomes from CRC patients and in CRC cell-derived exosomes. It promotes CRC progression by sponging miR-582-5p to enhance ZEB1 expression, thereby increasing cell proliferation, migration, invasion, metastasis, tumor formation and tumor growth. Its exosomal enrichment suggests potential value as a non-invasive biomarker for CRC screening and diagnosis."	0.6536
39636740	Cancer research	2025	Energy Stress-Induced circEPB41(2) Promotes Lipogenesis in Hepatocellular Carcinoma.	hsa_circ_0011167	circEPB41(2) 	hsa_circ_EPB41	EPB41	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circEPB41(2), also reported as circ_0011167/circ_NO.13, is a human EPB41-derived circRNA up-regulated in HCC and induced by glucose deprivation through HNRNPA1-dependent splicing. It promotes HCC lipogenesis and tumor growth by interacting with FTO, enhancing FTO demethylase activity, destabilizing SIRT6 mRNA, and increasing H3K9ac/H3K27ac-dependent lipogenic gene expression. Clinically, elevated circEPB41(2) is associated with poorer overall survival in patients with HCC."	0.895
39637799	Journal of hazardous materials	2025	Circular RNA circ_0061183 regulates microglial polarization induced by airborne ultrafine particles in HMC3 cells via sponging miR-98-5p.	hsa_circ_0061183	circ_0061183 	hsa_circ_DNAJC5	DNAJC5	Alzheimer's disease 	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR	"circ_0061183 is an AD-associated circRNA downregulated by PM 0.1 exposure, in 5xFAD mouse brain, and in blood from cognitively impaired elderly individuals. Mechanistically, it regulates microglial activation and polarization by sponging miR-98-5p and modulating IL10/BMP2/TGFbetaR1-related TGF-beta signaling. Clinically, lower circ_0061183 expression is associated with cognitive impairment, while higher expression relates to better MMSE scores and lower likelihood of cognitive impairment."	0.8314
39637854	Molecular cell	2025	p53 induces circFRMD4A to suppress cancer development through glycolytic reprogramming and cuproptosis.	hsa_circ_0004183	circFRMD4A	hsa_circ_FRMD4A	FRMD4A	colorectal cancer	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; ISH; Microarray	"circFRMD4A is a human FRMD4A-derived circRNA down-regulated in colorectal and breast cancer and functions as a tumor suppressor. p53 induces FRMD4A/circFRMD4A expression, while EWSR1 facilitates circFRMD4A biogenesis; circFRMD4A binds PKM2, inhibits PKM2 tetramerization and glycolysis, redirects glycolytic flux toward the TCA cycle, and sensitizes cancer cells to elesclomol-induced cuproptosis. Clinically, higher circFRMD4A expression is associated with better prognosis in colorectal cancer."	0.9032
39637854	Molecular cell	2025	p53 induces circFRMD4A to suppress cancer development through glycolytic reprogramming and cuproptosis.	hsa_circ_0004183	circFRMD4A	hsa_circ_FRMD4A	FRMD4A	breast cancer	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; ISH; Microarray	"circFRMD4A is a human FRMD4A-derived circRNA down-regulated in colorectal and breast cancer and functions as a tumor suppressor. p53 induces FRMD4A/circFRMD4A expression, while EWSR1 facilitates circFRMD4A biogenesis; circFRMD4A binds PKM2, inhibits PKM2 tetramerization and glycolysis, redirects glycolytic flux toward the TCA cycle, and sensitizes cancer cells to elesclomol-induced cuproptosis. Clinically, higher circFRMD4A expression is associated with better prognosis in colorectal cancer."	0.9032
39645568	Biotechnology and applied biochemistry	2024	Regulation of hsa_circ_0112136 by m6A demethylase FTO can enhance the malignancy of gastric cancer via the regulation of the PI3K/AKT/mTOR pathway.	hsa_circ_0112136		hsa_circ_NVL	NVL	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0112136 is up-regulated in gastric cancer and acts as an oncogenic circRNA. FTO-mediated demethylation decreases m6A modification of hsa_circ_0112136 and increases its expression, thereby promoting GC cell viability, migration, invasion and xenograft tumor growth through activation of the PI3K/AKT/mTOR pathway."	0.795
39647744	International journal of biological macromolecules	2025	Molecular mechanism of RB progression and Circ_0082415 inhibits MKLN1 translation to suppress retinoblastoma progression: Changes in mRNA and protein levels.	hsa_circ_0082415	Circ_0082415	hsa_circ_MKLN1	MKLN1	retinoblastoma 	MONDO:0008380	retinoblastoma	down-regulated	RT-qPCR	"MKLN1-derived hsa_circ_0082415 is down-regulated in retinoblastoma cells. Its overexpression suppresses RB cell growth, proliferation, migration and invasion while promoting apoptosis. Mechanistically, circ_0082415 interacts with HuR and inhibits HuR-mediated MKLN1 mRNA translation, reducing MKLN1 protein output and suppressing RB progression."	0.7812
39653202	International journal of biological macromolecules	2025	m6A-modified circCREBBP enhances radiosensitivity of esophageal squamous cell carcinoma by reducing the stability of MYC through interaction with IGF2BP3.	hsa_circ_0007637	circ-CREBBP 	hsa_circ_CREBBP	CREBBP	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	RT-qPCR; RNA-seq	"circCREBBP is a human CREBBP-derived circRNA that is downregulated in ESCC radioresistant tissues and cells. It enhances radiosensitivity by m6A-dependent competitive binding to IGF2BP3, thereby reducing IGF2BP3-mediated MYC mRNA stability. Functionally, circCREBBP knockdown promotes radioresistance and tumor growth after irradiation, whereas overexpression suppresses survival and increases apoptosis in ESCC cells."	0.8617
39653218	International journal of biological macromolecules	2025	Circular RNA 14580 promotes papillary thyroid cancer progression by interacting with CTSW/fibrosis singling pathway.	hsa_circ_0014580	circRNA_14580 			papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"circ_14580 is up-regulated in PTC tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation, migration, invasion, tumor growth, CAF activation, and collagen production, while circ_14580 knockdown induces apoptosis and suppresses malignant behaviors. Mechanistically, the study proposes a circ_14580/CTSW/fibrosis axis in which circ_14580 interacts with CTSW and modulates fibrosis-associated processes in the tumor microenvironment."	0.8074
39662264	International immunopharmacology	2025	CircSugp1 interacts with CPSF6 to modulate intestinal mucosa repair by regulating alternative polyadenylation-mediated shortening of the Wdr89 3'UTR.		CircSugp1 	mmu_circ_Sugp1	Sugp1	burned intestinal mucosa 	MONDO:0005020	intestinal disorder	down-regulated	RT-qPCR; Microarray	"CircSugp1 is downregulated in the intestinal mucosa of burned mice. It promotes proliferation and migration of MC38 cells and alleviates intestinal mucosal injury in a mouse third-degree burn model. Mechanistically, circSugp1 binds CPSF6 and upregulates CPSF6/Wdr89 signaling through alternative polyadenylation-mediated shortening of the Wdr89 3¡äUTR."	0.8095
39662265	International immunopharmacology	2025	CircFAM64A(3) promoted bladder cancer proliferation and inhibited CD8 + T cell via sponging to miR-149-5p and activated IL-6/JAK/STAT pathway.	hsa_circ_0041732	circFAM64A	hsa_circ_FAM64A	FAM64A	bladder cancer	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"CircFAM64A(3), also identified as hsa_circ_0041732, is up-regulated in bladder cancer and high expression is associated with poor prognosis. Functionally, it promotes bladder cancer proliferation and invasion and suppresses CD8+ T cell-mediated antitumor killing. Mechanistically, hypoxia-induced HIF-1alpha promotes circFAM64A(3) transcription, and circFAM64A(3) sponges miR-149-5p to increase IL-6, activate the JAK/STAT pathway, and elevate PD-L1 expression."	0.8942
39662901	The Tohoku journal of experimental medicine	2025	Circular RNA Hsa_circ_0007376 Promotes Malignancy of Gastric Cancer Cells by Regulating MiR-556-5p/CREB5 Axis.	hsa_circ_0007376	circMAP2K2	hsa_circ_MAP2K2	MAP2K2	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"CircMAP2K2 is upregulated in gastric cancer tissues and cell lines and high expression is associated with poorer patient survival. Functionally, circMAP2K2 promotes GC cell viability, proliferation, migration, and invasion. Mechanistically, it functions as a cytoplasmic ceRNA that sponges miR-556-5p to increase CREB5 expression, forming an oncogenic circMAP2K2/miR-556-5p/CREB5 axis."	0.8389
39663300	"Reproductive sciences (Thousand Oaks, Calif.)"	2025	Circ_0008440 Inhibits Proliferation and Promotes Apoptosis of Trophoblast Cells through the miR-194-5p/PFKFB2 Axis.	hsa_circ_0008440	circ_0008440	hsa_circ_FAM176A	FAM176A	Preeclampsia 	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR	"circ_0008440 is up-regulated in placental tissues from PE patients and may act as a biomarker for PE. Mechanistically, circ_0008440 sponges miR-942-5p to regulate PFKFB2, thereby inhibiting trophoblast cell proliferation and tube formation while promoting apoptosis."	0.7595
39667547	Cellular signalling	2025	Circ-SPATA13 regulates the osteogenic differentiation of human periodontal ligament stem cells through the miR-485-5p_R + 1/BMP7 axis.		circ-SPATA13	hsa_circ_SPATA13	SPATA13	periapical periodontitis 	MONDO:0004508	periapical periodontitis	unknown	RT-qPCR; RNA-seq	"circ-SPATA13 is a human PDLSC circRNA that positively regulates osteogenic differentiation and promotes bone formation in a rat skull defect model. Mechanistically, it acts as a ceRNA sponge for miR-485-5p_R + 1, relieving repression of BMP7 and enhancing osteogenesis-related markers and mineralization."	0.7221
39667599	Journal of hepatology	2025	A read-through circular RNA RCRIN inhibits metabolic dysfunction-associated steatotic liver disease.		RCRIN 	hsa_circ_RB1-ITM2B		metabolic dysfunction-associated steatotic liver disease 	MONDO:0013209	metabolic dysfunction-associated steatotic liver disease	down-regulated	RT-qPCR; Northern Blot; ISH; RNA-seq	"RCRIN is a conserved read-through circRNA that is downregulated in MASLD, MASH, and MASLD-related HCC liver samples. It suppresses MASLD progression by binding RPL8 and facilitating RNF2-dependent RPL8 ubiquitination/degradation, which limits RPL8-containing ribosomes, lipid-related protein translation, lipid accumulation, ER stress, insulin resistance, and liver damage. RCRIN overexpression showed therapeutic potential in diet-induced MASLD mouse models."	0.8821
39667599	Journal of hepatology	2025	A read-through circular RNA RCRIN inhibits metabolic dysfunction-associated steatotic liver disease.		RCRIN 	 mmu_circ_Rb1-Itm2b		metabolic dysfunction-associated steatotic liver disease 	MONDO:0013209	metabolic dysfunction-associated steatotic liver disease	down-regulated	RT-qPCR; Northern Blot; ISH; RNA-seq	"RCRIN is a conserved read-through circRNA that is downregulated in MASLD, MASH, and MASLD-related HCC liver samples. It suppresses MASLD progression by binding RPL8 and facilitating RNF2-dependent RPL8 ubiquitination/degradation, which limits RPL8-containing ribosomes, lipid-related protein translation, lipid accumulation, ER stress, insulin resistance, and liver damage. RCRIN overexpression showed therapeutic potential in diet-induced MASLD mouse models."	0.8821
39689861	Cancer biotherapy & radiopharmaceuticals	2025	EIF4A3-Induced hsa_circ_0118578 Expression Enhances the Tumorigenesis of Papillary Thyroid Cancer.	hsa_circ_0118578	hsa_-circ_0118578	hsa_circ_SATB2	SATB2	papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0118578 is upregulated in papillary thyroid cancer and is associated with more aggressive clinicopathologic features. Functionally, hsa_circ_0118578 promotes PTC cell proliferation, invasion, migration, and tumor growth, while its knockdown suppresses malignancy in vitro and in vivo. Mechanistically, EIF4A3 binds SATB2 pre-mRNA flanking sequences and enhances/stabilizes hsa_circ_0118578 expression."	0.6829
39690542	Zhonghua zhong liu za zhi [Chinese journal of oncology]	2024	[Non-small cell lung cancer-derived exosomal circular RNA circEZH2 activates fibroblasts by regulating the miR-495-3p / TPD52 axis and NF-kappaB pathway].	hsa_circ_0006357	circEZH2	hsa_circ_EZH2	EZH2	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"NSCLC-derived exosomal hsa_circ_0006357 (circEZH2) is upregulated in patient serum exosomes and in MRC-5 cells exposed to NSCLC-cell exosomes. circEZH2 promotes fibroblast activation, migration, invasion, and inflammatory gene expression by acting through the miR-495-3p/TPD52 axis and activating the NF-kappaB pathway."	0.6815
39692268	Molecular carcinogenesis	2025	M2 Macrophage-Derived Exosomal circ_0088494 Inhibits Ferroptosis via Promoting H3K4me1 Modification of STEAP3 in Cutaneous Squamous Cell Carcinoma.	hsa_circ_0088494	circ_0088494	hsa_circ_NEK6	NEK6	cutaneous squamous cell carcinoma 	MONDO:0002529	skin squamous cell carcinoma	up-regulated	RT-qPCR	"In this study, circ_0088494 is enriched in M2 macrophages and M2 macrophage-derived exosomes and is up-regulated in cSCC tissues. Exosomal circ_0088494 inhibits erastin-induced ferroptosis in cSCC cells by recruiting KMT2D to promote H3K4me1 modification and upregulation of STEAP3. The study suggests that the M2 exosome/circ_0088494/KMT2D/STEAP3 mechanism may represent a therapeutic target in cSCC."	0.6996
39692397	Journal of biochemical and molecular toxicology	2025	A Novel circ_0075829/miR-326/GOT1 ceRNA Crosstalk Regulates the Malignant Phenotypes and Drug Sensitivity of Gemcitabine-Resistant Pancreatic Cancer Cells.	hsa_circ_0075829	circ_0075829	hsa_circ_LINC00340	LINC00340	pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"circ_0075829 is upregulated in gemcitabine-resistant pancreatic cancer tissues and cells. It promotes malignant phenotypes, glutamine metabolism, tumor growth, and gemcitabine resistance by acting as a ceRNA for miR-326 to increase GOT1 expression. Silencing circ_0075829 suppresses tumorigenicity and enhances gemcitabine sensitivity in vitro and in vivo."	0.8175
39694006	Journal of hazardous materials	2025	circPRMT10 regulated by QKI hypermethylation attenuates lung tumorigenesis induced by tobacco carcinogen NNK.	hsa_circ_0009048	circPRMT10 	hsa_circ_PRMT10	PRMT10	lung cancer 	MONDO:0008903	lung cancer	down-regulated	RT-qPCR; Microarray	"circPRMT10 (hsa_circ_0009048), derived from PRMT10, is downregulated in NNK-exposed human bronchial epithelial cells and in lung cancer tissues. Its overexpression suppresses NNK-induced malignant transformation, lung cancer cell proliferation, cell-cycle progression, and xenograft tumor growth. Mechanistically, NNK-induced QKI promoter hypermethylation reduces QKI-dependent circPRMT10 biogenesis, while circPRMT10 interacts with MSN as a downstream target protein implicated in lung cancer progression."	0.8382
39694225	Cancer letters	2024	Super-enhancer-associated circPVT1 promotes malignancy of hepatocellular carcinoma via YBX1-mediated RRM2 activation.	hsa_circ_0001821	hsa_-circ_0001821 	hsa_circ_PVT1	PVT1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH	"circPVT1 is a super-enhancer-driven, PVT1-derived circRNA upregulated in HCC. It promotes HCC proliferation, invasion, tumour growth, and metastasis by binding YBX1 and recruiting it to the nucleus, thereby activating RRM2 transcription. High circPVT1 expression predicts worse OS and DFS and may represent a therapeutic target through inhibition of upstream super-enhancer signaling or downstream RRM2."	0.9026
39706052	Biochemical and biophysical research communications	2025	cDTL contributes to breast cancer progression through regulating redox homeostasis via affecting the function of system xc.		cDTL	hsa_circ_DTL	DTL	breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"cDTL is an up-regulated DTL-derived circular RNA in breast cancer that supports tumor cell growth by suppressing ferroptosis. Mechanistically, cDTL binds NRF2 in the nucleus to enhance SLC7A11 transcription and binds BCLAF1 in the cytoplasm to stabilize SLC7A11 mRNA, thereby activating the SLC7A11/GSH/GPX4 ferroptosis-resistance axis. High cDTL expression is associated with shorter progression-free survival and poor differentiation, suggesting therapeutic relevance."	0.8536
39708130	Pediatric surgery international	2024	Validation and in silico function prediction of circtial1 as a novel marker of abnormal lung development in nitrofen-induced congenital diaphragmatic hernia (CDH).		circtial1 	rno_circ_tial1	tial1	congenital diaphragmatic hernia 	MONDO:0005711	congenital diaphragmatic hernia	up-regulated	RT-qPCR; ISH; Microarray	"This study validated the exon 11-exon 2 backsplice junction of rat circtial1 in fetal lungs from a nitrofen-induced CDH model. Although total CDH lungs did not show a significant difference versus controls, male nitrofen-induced pups showed significantly increased circtial1 expression, indicating sex-specific dysregulation. In silico analyses predicted a circRNA-miRNA-mRNA mechanism involving inflammation/infection, immune regulation, and neuronal development/function-related pathways."	0.6149
39709098	Free radical biology & medicine	2025	CircMETTL9 targets CCAR2 to induce neuronal oxidative stress and apoptosis via mitochondria-mediated pathways following traumatic brain injury.		circMETTL9 	hsa_circ_METTL9	METTL9	traumatic brain injury 	MONDO:0858950	traumatic brain injury	up-regulated	RT-qPCR; ISH	"This study identifies circMETTL9 as an up-regulated circRNA in TBI-related brain injury and H_O_-induced neuronal oxidative stress models. circMETTL9 promotes ROS production, mitochondrial dysfunction, and neuronal apoptosis by binding to and positively regulating CCAR2, engaging the mitochondria-mediated Bax/Bcl-2/caspase-3 apoptotic pathway. Silencing circMETTL9 is presented as a potential strategy to reduce secondary neuronal injury after TBI."	0.6585
39709098	Free radical biology & medicine	2025	CircMETTL9 targets CCAR2 to induce neuronal oxidative stress and apoptosis via mitochondria-mediated pathways following traumatic brain injury.		circMETTL9 	rno_circ_METTL9	METTL9	traumatic brain injury 	MONDO:0858950	traumatic brain injury	up-regulated	RT-qPCR; ISH	"This study identifies circMETTL9 as an up-regulated circRNA in TBI-related brain injury and H_O_-induced neuronal oxidative stress models. circMETTL9 promotes ROS production, mitochondrial dysfunction, and neuronal apoptosis by binding to and positively regulating CCAR2, engaging the mitochondria-mediated Bax/Bcl-2/caspase-3 apoptotic pathway. Silencing circMETTL9 is presented as a potential strategy to reduce secondary neuronal injury after TBI."	0.6585
39710092	Cellular signalling	2025	Fusion circRNA F-circEA1 facilitates EML4-ALK1 positive lung adenocarcinoma progression through the miR-4673/SMAD4/ADAR1 axis.		F-circEA1 	hsa_circ_EML4-ALK1	EML4-ALK1	EML4-ALK1-positive lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	unknown	RT-qPCR; ISH	"F-circEA1 is a human fusion circRNA associated with EML4-ALK1-positive lung adenocarcinoma. It promotes malignant phenotypes of LUAD cells by sponging miR-4673 and participating in a feedback network involving SMAD4, ADAR1 and EML4-ALK1; F-circEA1 interference suppresses xenograft growth and EML4-ALK1 expression."	0.7629
39710273	Biochemical pharmacology	2025	CircDUSP16 mediates the effect of triple-negative breast cancer in pirarubicin via the miR-1224-3p/TFDP2 axis.	hsa_circ_0003855	circDUSP16 	hsa_circ_DUSP16	DUSP16	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"circDUSP16 (hsa_circ_0003855), derived from DUSP16, is upregulated in TNBC tissues, cells, and plasma exosomes and predicts poor overall survival when highly expressed in plasma exosomes. It promotes TNBC proliferation, migration, invasion, and xenograft growth mainly through a cytoplasmic ceRNA mechanism involving miR-1224-3p and TFDP2. Pirarubicin downregulates circDUSP16, suggesting that the circDUSP16/miR-1224-3p/TFDP2 axis may contribute to the therapeutic response in TNBC."	0.863
39710348	Microbial pathogenesis	2025	Whole transcriptome and proteome analyses identify ncRNAs and mRNAs to predict competing endogenous RNA networks in hepatitis B virus-induced hepatocellular carcinoma.	hsa_circ_0001098	hsa_-circ_0001098 			hepatitis B virus-induced hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0001098 is up-regulated in HBV-positive HepAD38 cells and HBV-related HCC tissues. It promotes HCC cell proliferation and progression through a ceRNA mechanism in which hsa_circ_0001098 sponges miR-2110 to increase IGF2BP1 expression.	0.7165
39715608	Gynecologic and obstetric investigation	2025	Circ_0008927 Promotes the Progression of Endometriosis via miR-608-/PROM2-Mediated Ferroptosis.	hsa_circ_0008927	Circ_0008927	hsa_circ_ATG7	ATG7	endometriosis 	MONDO:0005133	endometriosis	up-regulated	RT-qPCR	"circ_0008927 is up-regulated in endometriosis tissues and hEM15A cells. It promotes proliferation, migration, and invasion while inhibiting ferroptosis through a ceRNA mechanism involving miR-608 and PROM2, suggesting a potential therapeutic relevance in EM."	0.8341
39716648	Transplant immunology	2025	Novel insights into the circ_0003489/let-7b-5p/GLUT1 axis and its possible role in multiple myeloma.	hsa_circ_0003489	circ_0003489 	hsa_circ_CDK8	CDK8	multiple myeloma 	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR	"hsa_circ_0003489/circ_0003489 is up-regulated in bone marrow samples from MM patients and mainly localizes to the cytoplasm of MM cells. It promotes MM cell proliferation, glycolysis, BTZ resistance and in vivo tumor growth while inhibiting apoptosis, mechanistically acting through the circ_0003489/let-7b-5p/GLUT1 axis. The study proposes circ_0003489 as a potential therapeutic target for MM progression and chemoresistance."	0.8254
39716795	Current neurovascular research	2025	Inhibition of Circ0001679 Alleviates Ischemia/Reperfusion-induced Brain Injury via miR-216/TLR4 Regulatory Axis.	mmu_circ_0001679	Circ0001679			Ischemia/Reperfusion-induced Brain Injury	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR	"circ0001679 is up-regulated in OGD/R-treated primary mouse astrocytes and MCAO-induced mouse brain tissue. Its knockdown protects against ischemia/reperfusion-induced brain injury by reducing cellular damage, infarction, neuronal damage, apoptosis, inflammation, and oxidative stress. Mechanistically, circ0001679 functions through the miR-216/TLR4 regulatory axis and may be a therapeutic target for I/R-induced brain injury."	0.627
39717931	Journal of biochemical and molecular toxicology	2025	Sevoflurane Alleviates Myocardial Ischemia/Reperfusion Injury by Targeting the circ_CDR1as/miR-671-5p/HMGA1 Axis.		circ_CDR1as 	hsa_circ_CDR1as		myocardial ischemia/reperfusion injury 	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR	"In H/R cardiomyocytes modeling MI/RI, CDR1as is up-regulated and contributes to cardiomyocyte injury by reducing viability and promoting apoptosis, oxidative stress and inflammation. Sevoflurane suppresses CDR1as, thereby inhibiting the CDR1as/miR-671-5p/HMGA1 ceRNA axis and exerting cardioprotective effects."	0.6528
39721095	"Pathology, research and practice"	2025	The role of the circ_DOCK1-miR-1297-HOXA9 regulatory network in the development of oral squamous cell carcinoma.			hsa_circ_DOCK1	DOCK1	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circ_DOCK1 is up-regulated in OSCC tumor tissues and cell lines, and high expression is associated with advanced disease features and poor survival. Functionally, circ_DOCK1 promotes OSCC proliferation, colony formation, migration, invasion, glycolysis and in vivo tumor growth. Mechanistically, it acts as a miR-1297 sponge to increase HOXA9 expression through the circ_DOCK1-miR-1297-HOXA9 regulatory network."	0.8568
39729708	Journal of the National Comprehensive Cancer Network : JNCCN	2024	"Urinary Circular RNA Panels to Detect HBV-Related Hepatocellular Carcinoma: A Multicenter, Large-Scale, Case-Control Study."	hsa_circ_0075792	circ_0075792			HBV-related hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0075792 is a urinary circRNA biomarker that is significantly up-regulated in HBV-related HCC compared with healthy controls, CHB patients, and HBV-induced cirrhosis patients. It was incorporated into a three-circRNA logistic regression panel for noninvasive HCC detection, especially early HCC."	0.4187
39729708	Journal of the National Comprehensive Cancer Network : JNCCN	2024	"Urinary Circular RNA Panels to Detect HBV-Related Hepatocellular Carcinoma: A Multicenter, Large-Scale, Case-Control Study."	hsa_circ_0005397	circ_0005397			HBV-related hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0005397 is a urinary circRNA biomarker that is significantly up-regulated in HBV-related HCC compared with healthy controls, CHB patients, and HBV-induced cirrhosis patients. It was incorporated into a three-circRNA logistic regression panel for noninvasive HCC detection, especially early HCC."	0.4187
39729708	Journal of the National Comprehensive Cancer Network : JNCCN	2024	"Urinary Circular RNA Panels to Detect HBV-Related Hepatocellular Carcinoma: A Multicenter, Large-Scale, Case-Control Study."	hsa_circ_0000976	circ_0000976			HBV-related hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0000976 is a urinary circRNA biomarker that is significantly up-regulated in HBV-related HCC compared with healthy controls, CHB patients, and HBV-induced cirrhosis patients. It was incorporated into a three-circRNA logistic regression panel for noninvasive HCC detection, especially early HCC."	0.4187
39732142	American journal of perinatology	2025	CircTLK1 Knockdown Alleviates Cell Inflammation and Apoptosis by Regulating Elavl1/Nox4 Axis in Neonatal Sepsis-Induced Lung Injury in Mice.	mmu_circ_0001031	circular RNA TLK1 	mmu_circ_TLK1	TLK1	neonatal sepsis-induced acute lung injury 	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR	"This study identifies murine circTLK1, specifically mmu_circ_0001031, as up-regulated in neonatal sepsis-induced acute lung injury models. circTLK1 promotes inflammatory injury and apoptosis by interacting with Elavl1 and enhancing Nox4 mRNA stability, while circTLK1 knockdown alleviates lung injury in both LPS-treated PMECs and cecal slurry-induced neonatal mice."	0.5634
39736291	International journal of biological macromolecules	2025	Mmu_circ_0001148 promotes endothlial-mesenchymal transition via regulating miR-218-5p/JMY axis and drives progression of atherosclerosis.	Mmu_circ_0001148	circ_0001148 	mmu_circ_Ash1l	Ash1l	Atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR; Microarray	"circ_0001148 is a mouse circRNA derived from exons 3 and 4 of Ash1l and is up-regulated in atherosclerotic arterial tissues and ox-LDL-stimulated MAECs. It is predominantly cytoplasmic and promotes endothelial cell migration, EndMT, atherosclerotic plaque formation, and AS progression by acting as a ceRNA that sponges miR-218-5p and increases JMY expression. The study suggests circ_0001148 may be a potential biomarker and therapeutic target for AS."	0.8053
39736775	"Advances in rheumatology (London, England)"	2024	"Circ-PDE1C/miR-766-3p/SGTB axis regulates the IL-1beta-induced apoptosis, inflammation and oxidative stress in human chondrocytes."	hsa_circ_0134111	Circular RNA Phosphodiesterase 1 C 	hsa_circ_PDE1C	PDE1C	Osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"In this study, circ-PDE1C was up-regulated in OA cartilage tissues and IL-1beta-exposed human chondrocytes. Circ-PDE1C promoted IL-1beta-induced apoptosis, inflammation, ECM degradation and oxidative stress by sponging miR-766-3p and increasing SGTB expression, while circ-PDE1C knockdown exerted protective effects in the OA cell model."	0.7795
39740828	Anticancer research	2024	Circular RNA hsa_circ_0004650 Enhances 5-Fluorouracil Resistance in Gastric Cancer via Sponging miR-145-5p.	hsa_circ_0004650				gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0004650 is up-regulated in 5-Fu-resistant gastric cancer cell lines. It promotes 5-Fu resistance by sponging and negatively regulating miR-145-5p, thereby enhancing cell survival/proliferation and inhibiting apoptosis under 5-Fu treatment. The study proposes hsa_circ_0004650 as a potential therapeutic target for overcoming 5-Fu resistance in gastric cancer."	0.5804
39746596	Experimental cell research	2025	Circular RNA circPFKP suppress gastric cancer progression through targeting miR-346/CAMD3 axis.	hsa_circ_0006608		hsa_circ_PFKP	PFKP	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"circPFKP is down-regulated in gastric cancer tissues and cell lines and acts as a tumor-suppressive circRNA. It inhibits GC cell proliferation, migration, invasion, and xenograft tumor growth by functioning as a ceRNA that sponges miR-346 and up-regulates CADM3, suggesting potential diagnostic or therapeutic value."	0.7404
39748122	Cancer gene therapy	2025	Has_circ_ASH1L acts as a sponge for miR-1254 to promote the malignant progression of cervical cancer by targeting CD36.	hsa_circ_0000137		hsa_circ_ASH1L	ASH1L	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"circ_ASH1L is up-regulated in cervical cancer tissues and cell lines and shows oncogenic activity. It promotes proliferation, migration, invasion, and tumorigenesis while suppressing apoptosis by sponging miR-1254 and increasing CD36 expression. Its elevated expression is associated with advanced FIGO stage, low histological differentiation, and high SCC antigen levels, suggesting therapeutic relevance."	0.7898
39754006	Science China. Life sciences	2025	circTP63-N suppresses the proliferation and metastasis of nasopharyngeal carcinoma via engaging with HSP90AB1 to modulate the YAP1/Hippo signaling pathway.		circTP63-N	hsa_circ_TP63	TP63	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	down-regulated	RT-qPCR; ISH; RNA-seq	"circTP63-N is a novel TP63-derived circRNA that is significantly downregulated in nasopharyngeal carcinoma. It acts as a tumor suppressor by binding HSP90AB1, recruiting LATS1/2 and YAP1, promoting YAP1 phosphorylation and ubiquitination-dependent degradation, and suppressing YAP1/Hippo downstream oncogenic programs including INHBA, MMP3, and CCNE2. Restoration of circTP63-N inhibits NPC proliferation, invasion, migration, and metastasis in vitro and in vivo."	0.8869
39755856	"Journal of molecular medicine (Berlin, Germany)"	2025	CircRNA CDR1AS promotes cardiac ischemia-reperfusion injury in mice by triggering cardiomyocyte autosis.		CDR1AS 			myocardial ischemia/reperfusion injury 	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR	"CDR1AS is up-regulated in mouse myocardium after myocardial ischemia/reperfusion and in hypoxia-reoxygenated cardiomyocytes. It promotes cardiac IR injury by inducing excessive autophagy, autophagosome accumulation, lysosomal dysfunction, and cardiomyocyte autosis through interactions with LAMP2 and mTORC1/mTOR and partial regulation of the miR-7/LAMP2 pathway. Knockdown of CDR1AS improves cardiac function, reduces infarct area, restores autophagic flux, and alleviates cardiomyocyte injury."	0.7615
39761802	Gene	2025	"Hsa_circ_0002005 aggravates osteosarcoma by increasing cell proliferation, migration, and invasion."	hsa_circ_0002005		hsa_circ_MIER2	MIER2	osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"hsa_circ_0002005 is a MIER2-derived human circRNA that is up-regulated in osteosarcoma tissues and cell lines. Functional knockdown experiments show that it promotes OS cell proliferation, migration, invasion, EMT, and lung metastasis in vivo. The study suggests that hsa_circ_0002005 may act through a predicted circRNA-miRNA-mRNA network and may serve as a diagnostic biomarker or therapeutic target for OS."	0.7761
39765392	Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology	2025	Correlation of local and serum CircHIPK3 expressions with the progression of liver fibrosis/cirrhosis.		circular RNA HIPK3 	hsa_circ_HIPK3	HIPK3	liver fibrosis 	MONDO:0100430	fibrotic liver disease	up-regulated	RT-qPCR	"CircHIPK3 is upregulated in serum and liver tissues from patients with liver fibrosis/cirrhosis and increases with disease severity. Its expression correlates positively with Child-Pugh grade, Ishak necroinflammatory and fibrosis scores, serum ALT/AST, and tissue TGF-beta1/CollA1 mRNA, supporting its potential as a biomarker for LF/LC progression."	0.5127
39776010	Journal of biochemical and molecular toxicology	2025	circHOMER1 Alleviates Sevoflurane-Induced Hippocampal Neuronal Injury via Targeted Negative Regulation of miR-217.		circHOMER1 	mmu_circ_HOMER1 	HOMER1	Sev-induced neurotoxicity 	MONDO:0005527	toxic encephalopathy	down-regulated	RT-qPCR	"circHOMER1 is down-regulated after sevoflurane exposure in HT22 cells and rat hippocampal tissue. Its overexpression protects against sevoflurane-induced neuronal injury by reducing apoptosis, neuroinflammation, oxidative stress, and learning/memory impairment. Mechanistically, circHOMER1 targets and negatively regulates miR-217."	0.7204
39776010	Journal of biochemical and molecular toxicology	2025	circHOMER1 Alleviates Sevoflurane-Induced Hippocampal Neuronal Injury via Targeted Negative Regulation of miR-217.		circHOMER1 	 rno_circ_HOMER1	HOMER1	Sev-induced neurotoxicity 	MONDO:0005527	toxic encephalopathy	down-regulated	RT-qPCR	"circHOMER1 is down-regulated after sevoflurane exposure in HT22 cells and rat hippocampal tissue. Its overexpression protects against sevoflurane-induced neuronal injury by reducing apoptosis, neuroinflammation, oxidative stress, and learning/memory impairment. Mechanistically, circHOMER1 targets and negatively regulates miR-217."	0.7204
39776264	Molecular biology reports	2025	Evaluation of circ_0002232 and circ-vimentin gene expressions as valuable biomarkers in acute myeloid leukemia patients.	hsa_circ_0002232	circ_0002232	hsa_circ_PTEN	PTEN	acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	down-regulated	RT-qPCR	"In this clinical biomarker study, circ_0002232 was significantly down-regulated in AML patients compared with healthy controls and showed diagnostic value by ROC analysis. Lower circ_0002232 expression was associated with better overall survival, indicating that higher circ_0002232 expression was linked to poorer prognosis in this cohort."	0.4992
39776264	Molecular biology reports	2025	Evaluation of circ_0002232 and circ-vimentin gene expressions as valuable biomarkers in acute myeloid leukemia patients.		circ-VIM 	hsa_circ_VIM	VIM	acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"In this clinical biomarker study, circ-VIM was significantly up-regulated in AML patients compared with healthy controls and showed diagnostic value by ROC analysis. High circ-VIM expression was associated with leukocytosis and lack of complete remission, and the authors suggested it may influence AML prognosis despite no statistically significant OS association in this cohort."	0.4992
39777430	Fundamental & clinical pharmacology	2025	Fluoxetine-induced downregulation of circMap2k1 signaling cascade to improve neurological function after ischemic stroke.		circMap2k1 	rno_circ_Map2k1	Map2k1	ischemic stroke 	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; RNA-seq	"In the rat MCAO ischemic stroke model, circMap2k1 is up-regulated, while fluoxetine treatment down-regulates circMap2k1. circMap2k1 acts through a ceRNA-like circMap2k1/miR-135b-5p/Pidd1 axis to promote Pidd1 expression, neuroinflammatory responses related to microglial polarization, reduced hippocampal cell viability/proliferation, and apoptosis; knockdown of circMap2k1 enhances the protective effect of fluoxetine."	0.6835
39778893	DNA and cell biology	2025	Exosome-Delivered Hsa_Circ_0000116 Facilitates Osteosarcoma Cell Malignancy via PI3K/Akt/mTOR and p38/MAPK Pathways.	hsa_circ_0000116				osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"This study identifies exosome-delivered hsa_circ_0000116 as an up-regulated circRNA in osteosarcoma-derived exosomes. Functional knockdown experiments indicate that hsa_circ_0000116 promotes OS cell proliferation, migration, and invasion, at least partly by activating PI3K/Akt/mTOR and p38/MAPK pathways."	0.5067
39788357	Comparative biochemistry and physiology. Toxicology & pharmacology : CBP	2025	CircArid4b: A novel circular RNA regulating antibacterial response during hypoxic stress via apoptosis in yellow catfish (Pelteobagrus fulvidraco).		novel_circ_000753 	pfu_circ_Arid4b	Arid4b	Aeromonas veronii infection under hypoxia 	MONDO:1014952		down-regulated	RT-qPCR; RNA-seq	"circArid4b is a novel Arid4b-derived circRNA in yellow catfish that is significantly down-regulated during hypoxia combined with A. veronii infection. Its knockdown reduces Arid4b expression, promotes apoptosis and inflammatory responses, and enhances antibacterial resistance under hypoxic stress, suggesting circArid4b as a potential aquaculture target for infection prevention."	0.6148
39791285	Asia-Pacific journal of clinical oncology	2025	Molecular Mechanisms of circKIF4A in Breast Cancer Progression.		circRNA kinesin family member 4A (circKIF4A) 	hsa_circ_KIF4A	KIF4A	Breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circKIF4A is upregulated in human breast cancer cell lines and functions as an oncogenic circRNA. It is predominantly cytoplasmic and promotes proliferation, viability, migration, and invasion by sponging miR-874-3p and increasing GDPD5 expression, suggesting potential therapeutic relevance in BC."	0.7204
39800017	International journal of biological macromolecules	2025	5-Methylcytosine-modified circRNA-CCNL2 regulates vascular remdeling in hypoxic pulmonary hypertension through binding to FXR2.	hsa_circ_0003926	circCCNL2 	hsa_circ_CCNL2	CCNL2	pulmonary hypertension 	MONDO:0005149	pulmonary hypertension	down-regulated	RT-qPCR	"circCCNL2 is downregulated under hypoxic PH conditions and acts protectively by inhibiting PASMC proliferation, cell cycle progression, and pulmonary vascular remodeling. Its stability is maintained by NSUN2-mediated m5C modification, while its expression is regulated by SRSF2-dependent alternative splicing of CCNL2 pre-mRNA. Mechanistically, circCCNL2 binds FXR2 and limits FXR2/CDKL3 complex-mediated pro-proliferative signaling."	0.8535
39800368	Journal of clinical periodontology	2025	Targeting circFOXO3 to Modulate Integrin beta6 Expression in Periodontitis: A Potential Therapeutic Approach.		circFOXO3 	hsa_circ_FOXO3	FOXO3	periodontitis 	MONDO:0005076	periodontitis	up-regulated	RT-qPCR; ISH	"circFOXO3 is up-regulated in gingival epithelial tissues from patients with periodontitis and is mainly cytoplasmic. It promotes periodontal inflammation by sponging miR-141-3p, increasing FOXO3, forming a FOXO3-JunB transcriptional repression mechanism, down-regulating ITGbeta6, and inhibiting TGF-beta/Smad2 activity. In a rat ligature-induced periodontitis model, local si-circFOXO3 treatment alleviated inflammation and alveolar bone resorption, suggesting therapeutic potential."	0.8729
39803650	American journal of cancer research	2024	miR-542-3p/PIK3R1 axis is involved in hsa_circ_0087104-mediated inhibition of esophageal squamous cell carcinoma metastasis.	hsa_circ_0072389				esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	Microarray	"hsa_circ_0072389 was identified from GSE150476 as a downregulated circRNA in ESCC and metastatic ESCC tissues. The study predicted that it may participate in a circRNA-miRNA regulatory network through potential binding to miR-532-5p, but no RT-qPCR or functional validation was reported for this circRNA."	0.348
39803650	American journal of cancer research	2024	miR-542-3p/PIK3R1 axis is involved in hsa_circ_0087104-mediated inhibition of esophageal squamous cell carcinoma metastasis.	hsa_circ_0005062				esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	Microarray	"hsa_circ_0005062 was identified as a downregulated circRNA in ESCC progression and metastatic ESCC in GSE150476. Bioinformatic analyses predicted miRNA response elements, RBP sites, and an open reading frame, but no RT-qPCR or functional validation was reported for this circRNA."	0.348
39803650	American journal of cancer research	2024	miR-542-3p/PIK3R1 axis is involved in hsa_circ_0087104-mediated inhibition of esophageal squamous cell carcinoma metastasis.	hsa_circ_0072391				esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	Microarray	"hsa_circ_0072391 was identified as a downregulated circRNA across normal, ESCC, and metastatic ESCC tissues in GSE150476. Although structural features were predicted, no common binding miRNA from the two databases and no experimental functional validation were reported for this circRNA."	0.348
39803650	American journal of cancer research	2024	miR-542-3p/PIK3R1 axis is involved in hsa_circ_0087104-mediated inhibition of esophageal squamous cell carcinoma metastasis.	hsa_circ_0072386				esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	Microarray	"hsa_circ_0072386 was identified as a downregulated candidate circRNA associated with ESCC lymph node metastasis. Bioinformatic prediction suggested potential binding to miR-1252-5p, miR-382-3p, and miR-532-5p, but no RT-qPCR or functional validation was reported for this circRNA."	0.348
39803650	American journal of cancer research	2024	miR-542-3p/PIK3R1 axis is involved in hsa_circ_0087104-mediated inhibition of esophageal squamous cell carcinoma metastasis.	hsa_circ_0087104				esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0087104 is downregulated in ESCC and metastatic ESCC contexts and functions as a suppressor of ESCC cell migration and invasion. Mechanistically, it participates in a hsa_circ_0087104/miR-542-3p/PIK3R1 axis, increasing PIK3R1 expression while miR-542-3p counteracts this effect."	0.7165
39803650	American journal of cancer research	2024	miR-542-3p/PIK3R1 axis is involved in hsa_circ_0087104-mediated inhibition of esophageal squamous cell carcinoma metastasis.	hsa_circ_0015879				esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	Microarray	"hsa_circ_0015879 was identified from the GSE150476 circRNA microarray dataset as a downregulated circRNA in ESCC and metastatic ESCC tissues. The study considered it a potential circRNA associated with lymph node metastasis, but no mechanism or functional validation was reported for this circRNA."	0.348
39803650	American journal of cancer research	2024	miR-542-3p/PIK3R1 axis is involved in hsa_circ_0087104-mediated inhibition of esophageal squamous cell carcinoma metastasis.	hsa_circ_0026428				esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	Microarray	"hsa_circ_0026428 was identified from GSE150476 as a downregulated circRNA in ESCC and metastatic ESCC tissues. It was proposed as a potential circRNA associated with lymph node metastasis, but the paper did not report further mechanism or functional validation for this circRNA."	0.348
39803650	American journal of cancer research	2024	miR-542-3p/PIK3R1 axis is involved in hsa_circ_0087104-mediated inhibition of esophageal squamous cell carcinoma metastasis.	hsa_circ_0087212				esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	Microarray	"hsa_circ_0087212 was identified as a downregulated circRNA in ESCC and metastatic ESCC tissues using the GSE150476 microarray dataset. It was considered a potential circRNA associated with lymph node metastasis, but no specific mechanism or functional validation was reported."	0.348
39807080	Inflammatory bowel diseases	2025	hsa_circ_0015388 Reduces Macrophage Derived Reactive Oxygen Species in Crohn's Disease.	hsa_circ_0015388				Crohn's disease 	MONDO:0005011	Crohn disease	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0015388 was identified as significantly upregulated in terminal ileum biopsies from Crohn's disease patients and validated by qRT-PCR. It is expressed in macrophage-like THP-1 cells and suppresses macrophage-derived ROS production, at least partly through attenuation of the TNFSF10-mediated ROS pathway and potentially through sponging miR-140-3p and miR-338-3p. Clinically, its consistently high expression may help distinguish quiescent CD from non-CD."	0.7722
39818187	Biochemical and biophysical research communications	2025	Identification of a functional CircRNA-miRNA-mRNA network and inhibitory effect of Hsa_circ_0001681 on gliomas.	hsa_circ_0001681		hsa_circ_RAPGEF5	RAPGEF5	gliomas 	MONDO:0021042	glioma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001681 is a down-regulated circRNA in glioma and was experimentally validated as a circular transcript derived from RAPGEF5. Its overexpression suppresses glioma cell proliferation, migration, invasion and intracranial tumor growth, likely through a circRNA-miRNA-mRNA ceRNA network affecting PI3K-Akt, MAPK and Ras-related signaling."	0.6867
39818187	Biochemical and biophysical research communications	2025	Identification of a functional CircRNA-miRNA-mRNA network and inhibitory effect of Hsa_circ_0001681 on gliomas.	hsa_circ_0056281				gliomas 	MONDO:0021042	glioma	down-regulated	RNA-seq	"hsa_circ_0056281 was identified from GSE165926 as one of four markedly downregulated circRNAs in glioma tissues. It was incorporated into a predicted circRNA-miRNA-mRNA network with miRNA response elements and cancer-related pathway enrichment, but no successful RT-qPCR validation or functional assays were reported for this specific circRNA."	0.1768
39818187	Biochemical and biophysical research communications	2025	Identification of a functional CircRNA-miRNA-mRNA network and inhibitory effect of Hsa_circ_0001681 on gliomas.	hsa_circ_0062997				gliomas 	MONDO:0021042	glioma	down-regulated	RNA-seq	"hsa_circ_0062997 was identified from GSE165926 as one of four markedly downregulated circRNAs in glioma tissues. It was included in the predicted circRNA-miRNA-mRNA regulatory network, but no successful RT-qPCR validation or circRNA-specific functional experiment was reported for this circRNA."	0.1768
39818187	Biochemical and biophysical research communications	2025	Identification of a functional CircRNA-miRNA-mRNA network and inhibitory effect of Hsa_circ_0001681 on gliomas.	hsa_circ_0055954				gliomas 	MONDO:0021042	glioma	down-regulated	RNA-seq	"hsa_circ_0055954 was identified as a markedly downregulated circRNA in glioma tissues using GSE165926 high-throughput sequencing data. It was analyzed as part of a predicted ceRNA network, but no circRNA-specific RT-qPCR-confirmed expression change or functional experiment was reported for this circRNA."	0.1768
39818375	International journal of biological macromolecules	2025	CircNIPBLL modulates the inflammatory response against Eimeria tenella infection via sponging gga-miR-2954.		circ-NIPBLL 	gga_circ_NIPBLL	NIPBLL	Coccidiosis 	MONDO:0005707	coccidiosis	dysregulated	RNA-seq	"circNIPBLL is a chicken circRNA derived from NIPBLL that is differentially expressed during coccidial infection and mainly localizes in the cytoplasm. In sporozoite-stimulated DF-1 cells, circNIPBLL promotes inflammatory cytokine production and apoptosis. Mechanistically, it functions as a sponge for gga-miR-2954 and is linked to the circNIPBLL-gga-miR-2954-RORC regulatory axis in the inflammatory response against E. tenella infection."	0.7898
39820928	Applied biochemistry and biotechnology	2025	Circ-NMNAT1 Drives Tumor Progression in Bladder Cancer by Modulating the miR-370-3p/ATXN2L Axis.	hsa_circ_0110116	circ-NMNAT1	hsa_circ_NMNAT1	NMNAT1	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circ-NMNAT1 is up-regulated in bladder cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes BCa cell proliferation, migration, invasion, EMT-related changes and xenograft tumor growth, while suppressing apoptosis, mainly through sponging miR-370-3p and thereby increasing ATXN2L expression. Its expression is associated with aggressive clinicopathologic features and may represent a therapeutic target."	0.8298
39826668	Cancer letters	2025	circCCNY enhances lenvatinib sensitivity and suppresses immune evasion in hepatocellular carcinoma by serving as a scaffold for SMURF1 mediated HSP60 degradation.	hsa_circ_0000235	circCCNY 	hsa_circ_CCNY	CCNY	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; ISH; RNA-seq	"circCCNY/hsa_circ_0000235 is downregulated in HCC tissues and lenvatinib-resistant HCC cells, and higher expression is associated with favorable survival. Functionally, circCCNY suppresses tumor progression and lenvatinib resistance while promoting antitumor immune activity. Mechanistically, it scaffolds the HSP60/SMURF1 complex to promote HSP60 ubiquitination and degradation, thereby inhibiting MAPK and HSP60/MAPK/c-Myc/PD-L1 signaling."	0.8949
39826668	Cancer letters	2025	circCCNY enhances lenvatinib sensitivity and suppresses immune evasion in hepatocellular carcinoma by serving as a scaffold for SMURF1 mediated HSP60 degradation.			mmu_circ_Ccny	Ccny	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; ISH; RNA-seq	"circCCNY/hsa_circ_0000235 is downregulated in HCC tissues and lenvatinib-resistant HCC cells, and higher expression is associated with favorable survival. Functionally, circCCNY suppresses tumor progression and lenvatinib resistance while promoting antitumor immune activity. Mechanistically, it scaffolds the HSP60/SMURF1 complex to promote HSP60 ubiquitination and degradation, thereby inhibiting MAPK and HSP60/MAPK/c-Myc/PD-L1 signaling."	0.8949
39832103	Applied biochemistry and biotechnology	2025	Circular RNA ATP9A Stimulates Non-small Cell Lung Cancer Progression via MicroRNA-582-3p/Ribosomal Protein Large P0 Axis and Activating Phosphatidylinositol 3-Kinase/Protein Kinase B Signaling Pathway.	hsa_circ_0008253	circATP9A 	hsa_circ_ATP9A	ATP9A	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circATP9A (hsa_circ_0008253) is up-regulated in NSCLC tissues and cell lines. It functions as an oncogenic circRNA by sponging miR-582-3p, increasing RPLP0 expression, activating PI3K/Akt signaling, and thereby promoting proliferation, invasion, migration, EMT and xenograft tumor growth while inhibiting apoptosis. Its high expression is associated with lymph node metastasis and TNM staging, suggesting potential clinical biomarker value."	0.8512
39832205	Neoplasma	2024	hsa_circ_0021727 facilitates esophageal squamous cell carcinoma progression by stabilizing GBX2 mRNA through interacting with EIF4A3.	hsa_circ_0021727	circ_0021727	hsa_circ_CD44	CD44	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"hsa_circ_0021727 is up-regulated in ESCC cells and promotes malignant progression. Mechanistically, it binds/recruits the RBP EIF4A3 to stabilize GBX2 mRNA, increasing GBX2 expression and thereby promoting cell cycle progression, angiogenesis, cell viability, and xenograft tumor growth while inhibiting apoptosis."	0.7597
39832206	Neoplasma	2024	circ_0075829 regulates ferroptosis and immune escape in colon cancer cells through the miR-330-5p/TCF4 axis.	hsa_circ_0075829	circ_0075829	hsa_circ_LINC00340		colon cancer	MONDO:0021063	malignant colon neoplasm	unknown	RT-qPCR	"This study shows that circ_0075829 regulates ferroptosis and immune escape in colon cancer cells through the miR-330-5p/TCF4 axis. Knockdown of circ_0075829 increases ferroptosis markers, decreases GPX4/xCT and PD-L1, enhances CD8+ T-cell activity and cytokine secretion, and suppresses xenograft tumor growth, suggesting a potential diagnostic and immunotherapy-related target."	0.705
39842531	Cellular signalling	2025	CircMRP4 orchestrates podocytes injury via the miR-499-5p/RRAGB/mTORC1 axis in diabetic kidney disease.	mmu_circ_0004979	mmu-Abcc4_0013 	mmu_circ_ABCC4	ABCC4 / MRP4	Diabetic kidney disease 	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR; RNA-seq	"circMRP4 is a mouse ABCC4-derived circRNA up-regulated in kidney tissues, blood, and urine of db/db DKD mice and in high-glucose-stimulated MPC5 podocytes. It promotes podocyte apoptosis and inflammation by sponging miR-499-5p, increasing RRAGB expression, and activating the mTORC1/P70S6K pathway. The study proposes circMRP4 as a potential therapeutic target for DKD."	0.848
39855483	Genomics	2025	Transcriptomics reveals the regulatory mechanisms of circRNA in the muscle tissue of cows with ketosis postpartum.		"circ-30,628 "			ketosis 	MONDO:0024913	cattle disease	dysregulated	RNA-seq	"circ30628 was identified as a key differentially expressed circRNA in muscle tissue of ketosis-affected postpartum dairy cows. The study predicts that it participates in a circRNA-miRNA-mRNA regulatory network related to carbon metabolism, energy metabolism, oxidative stress, and muscle-cell functional processes."	0.2414
39855483	Genomics	2025	Transcriptomics reveals the regulatory mechanisms of circRNA in the muscle tissue of cows with ketosis postpartum.			bta_circ_CoQ2	CoQ2	ketosis 	MONDO:0024913	cattle disease	up-regulated	RNA-seq	"circCoQ2 was identified as an up-regulated key circRNA in muscle tissue of ketosis-affected postpartum dairy cows. The study predicts that it may act through a circRNA-miRNA-mRNA network and is associated with mitochondrial energy metabolism, mitochondrial function, oxidative stress, and energy metabolism-related signaling pathways."	0.2414
39855736	Annals of clinical and laboratory science	2024	Effect of CXCR2 Deficiency in HeLa Cell on the Regulatory Network of Coding Genes and Non-Coding RNAs.	hsa_circ_0000196		hsa_circ_EGLN1	EGLN1	cervical cancer	MONDO:0002974	cervical cancer	unknown	RT-qPCR; RNA-seq	hsa_circ_0000196 was identified as a CXCR2 deficiency-associated differentially expressed circRNA in HeLa cells. It was selected from HIF-1 signaling pathway-enriched circRNAs and validated by real-time PCR and Sanger sequencing as a potential key player in cervical cancer.	0.3858
39855736	Annals of clinical and laboratory science	2024	Effect of CXCR2 Deficiency in HeLa Cell on the Regulatory Network of Coding Genes and Non-Coding RNAs.	hsa_circ_0000234		hsa_circ_CUL2	CUL2	cervical cancer	MONDO:0002974	cervical cancer	unknown	RT-qPCR; RNA-seq	hsa_circ_0000234 was identified as a CXCR2 deficiency-associated differentially expressed circRNA in HeLa cells. It was linked to HIF-1 signaling pathway enrichment through CUL2 and validated by real-time PCR and Sanger sequencing.	0.3858
39855736	Annals of clinical and laboratory science	2024	Effect of CXCR2 Deficiency in HeLa Cell on the Regulatory Network of Coding Genes and Non-Coding RNAs.	hsa_circ_0007976		hsa_circ_HIF1A	HIF1A	cervical cancer	MONDO:0002974	cervical cancer	unknown	RT-qPCR; RNA-seq	hsa_circ_0007976 was identified as a CXCR2 deficiency-associated differentially expressed circRNA in HeLa cells. Its host gene HIF1A places it among HIF-1 signaling pathway-enriched circRNAs proposed as potential key players in cervical cancer.	0.3858
39855736	Annals of clinical and laboratory science	2024	Effect of CXCR2 Deficiency in HeLa Cell on the Regulatory Network of Coding Genes and Non-Coding RNAs.	hsa_circ_0008798		hsa_circ_MAP2K1	MAP2K1	cervical cancer	MONDO:0002974	cervical cancer	unknown	RT-qPCR; RNA-seq	hsa_circ_0008798 was identified as a CXCR2 deficiency-associated differentially expressed circRNA in HeLa cells. It was selected from HIF-1 signaling pathway-enriched circRNAs and validated as a potential key player in cervical cancer.	0.3858
39855736	Annals of clinical and laboratory science	2024	Effect of CXCR2 Deficiency in HeLa Cell on the Regulatory Network of Coding Genes and Non-Coding RNAs.	hsa_circ_0007766		hsa_circ_ERBB2	ERBB2	cervical cancer	MONDO:0002974	cervical cancer	unknown	RT-qPCR; RNA-seq	"hsa_circ_0007766 was identified as a validated CXCR2 deficiency-associated differentially expressed circRNA in HeLa cells. It is linked to HIF-1 signaling through its host gene ERBB2 and was predicted to interact with hsa-miR-608, suggesting a potential role in cervical cancer pathology."	0.3858
39855736	Annals of clinical and laboratory science	2024	Effect of CXCR2 Deficiency in HeLa Cell on the Regulatory Network of Coding Genes and Non-Coding RNAs.	hsa_circ_0116612		hsa_circ_EP300	EP300	cervical cancer	MONDO:0002974	cervical cancer	unknown	RT-qPCR; RNA-seq	hsa_circ_0116612 was identified as a validated CXCR2 deficiency-associated differentially expressed circRNA in HeLa cells. It was selected from HIF-1 signaling pathway-enriched circRNAs through its host gene EP300 and proposed as a potential cervical cancer-related circRNA.	0.3858
39855736	Annals of clinical and laboratory science	2024	Effect of CXCR2 Deficiency in HeLa Cell on the Regulatory Network of Coding Genes and Non-Coding RNAs.	hsa_circ_0008012		hsa_circ_NFKB1	NFKB1	cervical cancer	MONDO:0002974	cervical cancer	unknown	RT-qPCR; RNA-seq	hsa_circ_0008012 was identified as a CXCR2 deficiency-associated differentially expressed circRNA in HeLa cells. It was selected among HIF-1 signaling pathway-enriched circRNAs through NFKB1 and validated by real-time PCR and Sanger sequencing.	0.3858
39855736	Annals of clinical and laboratory science	2024	Effect of CXCR2 Deficiency in HeLa Cell on the Regulatory Network of Coding Genes and Non-Coding RNAs.	hsa_circ_0004576		hsa_circ_PRKCA	PRKCA	cervical cancer	MONDO:0002974	cervical cancer	unknown	RT-qPCR; RNA-seq	hsa_circ_0004576 was identified as a validated CXCR2 deficiency-associated differentially expressed circRNA in HeLa cells. It is associated with the HIF-1 signaling pathway through host gene PRKCA and was proposed as a potential key player in cervical cancer.	0.3858
39855736	Annals of clinical and laboratory science	2024	Effect of CXCR2 Deficiency in HeLa Cell on the Regulatory Network of Coding Genes and Non-Coding RNAs.	hsa_circ_0118105		hsa_circ_PDK1	PDK1	cervical cancer	MONDO:0002974	cervical cancer	unknown	RT-qPCR; RNA-seq	hsa_circ_0118105 was identified as a validated CXCR2 deficiency-associated differentially expressed circRNA in HeLa cells. It was selected among HIF-1 signaling pathway-enriched circRNAs through host gene PDK1 and proposed as a potential key player in cervical cancer.	0.3858
39862920	Cancer letters	2025	CircKIAA0182-YBX1 Axis: A Key Driver of Lung Cancer Progression and Chemoresistance.		circKIAA0182 	hsa_circ_KIAA0182	KIAA0182	Lung cancer 	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; RNA-seq	"circKIAA0182 is up-regulated in NSCLC tissues, lung cancer cell lines, and cisplatin-resistant A549-DDP cells. Functionally, it promotes lung cancer proliferation, migration, invasion, in vivo tumor growth, and cisplatin resistance while suppressing apoptosis. Mechanistically, the study supports a circKIAA0182-YBX1 RBP axis in which circKIAA0182 may stabilize YBX1 to drive tumor progression and chemoresistance."	0.8355
39863187	Genomics	2025	CircPIK3C3 inhibits hepatocellular carcinoma progression and lenvatinib resistance by suppressing the Wnt/beta-catenin pathway via the miR-452-5p/SOX15 axis.	hsa_circ_0005711	circPIK3C3 	hsa_circ_PIK3C3	PIK3C3	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"circPIK3C3 is a human PIK3C3-derived circRNA that is down-regulated in HCC tissues, HCC cells, and lenvatinib-resistant HCC cells. It suppresses HCC progression and lenvatinib resistance by sponging miR-452-5p, increasing SOX15 expression, and inhibiting Wnt/beta-catenin signaling. Higher circPIK3C3 expression is associated with better OS and RFS, supporting its potential as a prognostic biomarker and marker of lenvatinib response."	0.8981
39863188	Experimental gerontology	2025	CircXYLT1 suppresses oxidative stress and promotes vascular remodeling in aging mice carotid artery injury model of atherosclerosis via PTBP1.			mmu_circ_XYLT1	XYLT1	atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR; RNA-seq	"CircXYLT1 is upregulated in age-related atherosclerotic vascular tissues and promotes VSMC proliferation and neointimal hyperplasia while suppressing oxidative stress. It acts through direct interaction with PTBP1, reducing PTBP1 nuclear localization and modulating chemokine signaling-related inflammatory/oxidative responses."	0.7924
39867828	Cytotechnology	2025	Mechanism underlying the role of the circRNA OMA1/miR-654-3p/RAF1 axis in children with inflammatory bowel disease.			hsa_circ_OMA1	OMA1	Inflammatory bowel disease 	MONDO:0005265	inflammatory bowel disease	down-regulated	RT-qPCR	"circRNA OMA1 is downregulated in the serum of children with IBD and in DSS-treated HT-29 cells. Its overexpression protects against DSS-induced colonic epithelial injury by sponging miR-654-3p, thereby modulating RAF1 expression, reducing apoptosis and inflammatory cytokine release, and improving cell viability. The study suggests circRNA OMA1 as a potential biomarker and therapeutic target for pediatric IBD."	0.6521
39881045	Molecular biology reports	2025	Evaluation of the role of circular RNA (circ-FAF1) as a diagnostic biomarker for breast cancer in a cohort of Egyptian breast cancer patients.	hsa_circ_0004619	circ-FAF1 	hsa_circ_FAF1	FAF1	breast cancer	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	"This case-control clinical study found that serum circ-FAF1 is significantly down-regulated in female breast cancer patients compared with healthy controls. Low circ-FAF1 expression is associated with lymph node spread, metastasis, ER negativity, HER2 positivity and higher Ki-67, and serum circ-FAF1 showed promising diagnostic performance by ROC analysis."	0.459
39894158	Journal of dentistry	2025	CircFak promotes mechanical force-induced osteogenesis via FAK/AKT phosphorylation.		circ_014111 	mmu_circ_Fak	Fak	malocclusion 	MONDO:0009555	malocclusion and short stature	up-regulated	RT-qPCR; Microarray	"circFak is a murine Fak-derived circular RNA that is up-regulated in osteoblasts under mechanical force. It promotes osteogenic differentiation and mechanical force-induced osteogenesis by sponging miR-425-5p to increase Ccn3 expression and activate FAK/AKT phosphorylation. In a mouse orthodontic tooth movement model, AAV-mediated circFak knockdown reduced osteogenesis, suggesting potential value as a biomarker for orthodontic treatment prognosis."	0.8447
39901544	Combinatorial chemistry & high throughput screening	2025	Hsa_circ_0030568 Promotes the Proliferation and Migration of Prostate Cancer Cells via the miR-141-3p-BRD4 Axis.	hsa_circ_0030568	circ_0030568 	hsa_circ_ABCC4	ABCC4	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0030568 is up-regulated in prostate cancer cells and promotes PCa cell proliferation and migration. Mechanistically, it sponges miR-141-3p to increase BRD4 expression, thereby exacerbating PCa progression. The study proposes the circ_0030568-BRD4 axis as a potential biomarker and therapeutic target for PCa."	0.7615
39904903	Journal of physiological investigation	2025	CircRNA-0013747 Promotes Mesangial Cell Proliferation in Immunoglobulin A Nephropathy through Modulation of the Warburg Effect.	hsa_circ_0013747		hsa_circ_MAN1A2	MAN1A2	Immunoglobulin A nephropathy	MONDO:0005342	IgA glomerulonephritis	up-regulated	RT-qPCR; ISH	"hsa_circ_0013747 is up-regulated in human IgAN kidney tissues and promotes mesangial cell proliferation and aerobic glycolysis. Mechanistically, it sponges miR-330-3p to derepress PKM2 expression, forming a circRNA_0013747/miR-330-3p/PKM2 axis with potential biomarker and therapeutic relevance."	0.8439
39904903	Journal of physiological investigation	2025	CircRNA-0013747 Promotes Mesangial Cell Proliferation in Immunoglobulin A Nephropathy through Modulation of the Warburg Effect.	mmu_circ_0010297		mmu_circ_MAN1A2	MAN1A2	Immunoglobulin A nephropathy 	MONDO:0005342	IgA glomerulonephritis	up-regulated	RT-qPCR	"mmu_circ_0010297 is a MAN1A2-derived mouse homolog of hsa_circ_0013747 and is up-regulated in kidneys of an IgAN mouse model. AAV-mediated knockdown decreases lactate accumulation, reverses PKM2/fibronectin/collagen IV expression, reduces glomerulosclerosis and collagen deposition, and improves renal injury markers."	0.5214
39909178	Cellular signalling	2025	CircHOMER1 promotes silica-induced pulmonary fibrosis by binding to HuR and stabilizing NOX4 mRNA.	hsa_circ_0006916	circHOMER1	hsa_circ_HOMER1	HOMER1	silicosis 	MONDO:0005960	silicosis	up-regulated	RT-qPCR; RNA-seq	"circHOMER1 is up-regulated in silicosis-related pulmonary fibrosis and in TGF-beta1-treated lung fibroblasts. It promotes fibrotic progression by binding HuR, enhancing HuR protein stability, and enabling HuR-mediated stabilization of NOX4 mRNA, which increases NOX4/ROS signaling and fibrotic molecule production. Knockdown of circHOMER1 alleviates silica-induced lung fibrosis in vivo, suggesting therapeutic potential."	0.734
39914785	European journal of pharmacology	2025	Exonic CircGUCY1A2 inhibits pulmonary artery smooth muscle cells phenotypic switching via regulating O-glycosylation of COL3A1 in pulmonary hypertension.			hsa_circ_GUCY1A2	GUCY1A2	pulmonary hypertension 	MONDO:0005149	pulmonary hypertension	down-regulated	RT-qPCR	"circGUCY1A2 is downregulated under hypoxic PH-related conditions and acts as an inhibitory regulator of PASMC phenotypic switching. Mechanistically, it binds COL3A1 at Ser1132/Ser1145 O-glycosylation sites, reduces COL3A1 glycosylation and stability, affects OPN expression, and suppresses PASMC proliferation, migration, pulmonary vascular remodeling, and pulmonary artery fibrosis."	0.8479
39914785	European journal of pharmacology	2025	Exonic CircGUCY1A2 inhibits pulmonary artery smooth muscle cells phenotypic switching via regulating O-glycosylation of COL3A1 in pulmonary hypertension.			mmu_circ_Gucy1a2	Gucy1a2	pulmonary hypertension 	MONDO:0005149	pulmonary hypertension	down-regulated	RT-qPCR	"circGUCY1A2 is downregulated under hypoxic PH-related conditions and acts as an inhibitory regulator of PASMC phenotypic switching. Mechanistically, it binds COL3A1 at Ser1132/Ser1145 O-glycosylation sites, reduces COL3A1 glycosylation and stability, affects OPN expression, and suppresses PASMC proliferation, migration, pulmonary vascular remodeling, and pulmonary artery fibrosis."	0.8479
39927135	Cytotechnology	2025	"circDHX33 suppresses glycolysis, malignant proliferation, and metastasis in prostate cancer by interacting with RNA-binding protein IGF2BP2 to destabilize its protein."	hsa_circ_0000740	circDHX33	hsa_circ_DHX33	DHX33	prostate cancer 	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; Microarray	"CircDHX33 is down-regulated in prostate cancer tissues and cell lines. It functions as a tumor-suppressive circRNA by binding the RNA-binding protein IGF2BP2, reducing IGF2BP2 protein stability/expression, and thereby inhibiting glycolysis, proliferation, migration, invasion, EMT, tumor growth, and metastasis while promoting apoptosis. Low circDHX33 expression is associated with advanced TNM stage and distant metastasis, supporting its potential biomarker and therapeutic relevance."	0.8571
39930271	Oncogene	2025	circAFF2 promotes the development of AML by binding to PML mRNA.		circAFF2	hsa_circ_AFF2	AFF2	acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; RNA-seq	"circAFF2 is a human AFF2-derived circRNA that is significantly upregulated in AML patients and AML cell lines. It promotes AML cell proliferation and suppresses apoptosis by directly binding the 3¡äUTR of PML mRNA, accelerating PML mRNA degradation and reducing PML tumor suppressor expression. Knockdown of circAFF2 alleviates AML progression in a cell line-derived xenograft model and prolongs mouse survival."	0.8416
39933635	Cancer letters	2025	CircMFN2/miR-361-3p/ELK1 feedback loop promotes glutaminolysis and the progression of hepatocellular carcinoma.	hsa_circ_0009910	circMFN2	hsa_circ_MFN2	MFN2	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circMFN2/hsa_circ_0009910 is an upregulated circRNA derived from MFN2 in HCC. It acts as an oncogenic cytoplasmic ceRNA by sponging miR-361-3p, thereby increasing ELK1 and forming a positive circMFN2/miR-361-3p/ELK1 feedback loop that promotes proliferation, migration, invasion, metastasis, and glutaminolysis through phosphorylated ELK1. Clinically, high circMFN2 expression predicts poor OS and DFS and may serve as a prognostic biomarker and therapeutic target."	0.9019
39957397	Biotechnology and applied biochemistry	2025	A Preliminary Study of CircRNA Expression Characteristics in the Progression of Colorectal Cancer.	hsa_circ_0000007				Colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	Microarray	hsa_circ_0000007 was identified as a key circRNA whose expression decreased with CRC progression. The study suggests it may be associated with RB1-mediated G1-S phase transcriptional regulation and may serve as a biomarker for CRC diagnosis and staging.	0.348
39957397	Biotechnology and applied biochemistry	2025	A Preliminary Study of CircRNA Expression Characteristics in the Progression of Colorectal Cancer.	hsa_circ_0023608				Colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	Microarray	hsa_circ_0023608 was identified as a key circRNA downregulated in CRC and decreasing with CRC progression. It was associated with RB1-related G1-S phase transcriptional regulation and may be useful as a biomarker for CRC diagnosis and staging.	0.348
39957397	Biotechnology and applied biochemistry	2025	A Preliminary Study of CircRNA Expression Characteristics in the Progression of Colorectal Cancer.	hsa_circ_0026694				Colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	Microarray	hsa_circ_0026694 was identified as a key circRNA downregulated in CRC and decreasing with CRC progression. It was associated with RB1-related G1-S phase transcriptional regulation and may be useful as a biomarker for CRC diagnosis and staging.	0.348
39957397	Biotechnology and applied biochemistry	2025	A Preliminary Study of CircRNA Expression Characteristics in the Progression of Colorectal Cancer.	hsa_circ_0029903				Colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	Microarray	hsa_circ_0029903 was identified as a key circRNA downregulated in CRC and decreasing with CRC progression. It was associated with RB1-related G1-S phase transcriptional regulation and may be useful as a biomarker for CRC diagnosis and staging.	0.348
39957592	Critical reviews in eukaryotic gene expression	2025	CircCNKSR2 Facilitates NSCLC Tumorigenesis and Warburg Effect via miRNA-138-5p/PLEK2 Axis.		CircCNKSR2 	hsa_circ_CNKSR2	CNKSR2	Non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circCNKSR2 is up-regulated in NSCLC tissues and cells and mainly localized in the cytoplasm. It promotes NSCLC tumorigenesis, malignant cell behaviors and Warburg effect by sponging miR-138-5p and thereby increasing PLEK2 expression. The study suggests circCNKSR2 may be a diagnostic biomarker and therapeutic target for NSCLC."	0.7795
39960214	Molecular carcinogenesis	2025	CircST6GALNAC6 Inhibits Glycolysis of Bladder Cancer by Regulating PRKN/HK1 Signaling Pathway.		circST6GALNAC6 	hsa_circ_ST6GALNAC6	ST6GALNAC6	Bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR	"CircST6GALNAC6 is down-regulated in bladder cancer cells and acts as a tumor-suppressive circRNA. Its overexpression inhibits glycolysis, proliferation, and xenograft tumor growth by recruiting FUS to stabilize PRKN mRNA, which promotes ubiquitination-related HK1 degradation through the PRKN/HK1 signaling cascade."	0.7581
39960277	Alternative therapies in health and medicine	2025	"Integrated Analysis of mRNAs, lncRNAs, and circRNAs Expression Profile in Human Colorectal Cancer."	hsa_circ_0025288	circ_0025288			colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0025288/circ_0025288 was identified as an up-regulated circRNA in HCT116 colorectal cancer cells compared with FHC colorectal epithelial cells, with expression supported by microarray and RT-qPCR. Bioinformatics analysis predicted that circ_0025288 may interact with miRNAs such as miR-181a-3p and miR-455-5p, suggesting a potential circRNA-miRNA regulatory role in CRC pathogenesis and a possible therapeutic target value."	0.2465
39960585	Molecular and cellular biochemistry	2025	Upregulation of YY1 in M2 macrophages promotes secretion of exosomes containing hsa-circ-0000326 via super-enhancers to facilitate prostate cancer progression.	hsa_circ_0000326		hsa_circ_MALAT1	MALAT1	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	"YY1-overexpressing M2 macrophages increase secretion of exosomes containing hsa-circ-0000326, which is transferred into prostate cancer cells and promotes migration, invasion, proliferation, EMT, and metastasis. Mechanistically, hsa-circ-0000326 acts as a miR-338-3p sponge to increase AR expression, while YY1 also promotes its biogenesis by enhancing MALAT1 transcription through a super-enhancer and upregulating QKI."	0.8027
39962265	Acta pharmacologica Sinica	2025	Circular RNA hsa_circ_0000288 protects against epilepsy in mice by binding to and stabilizing caprin1 protein.	hsa_circ_0000288	circ288 	hsa_circ_CAPRIN1	caprin1	epilepsy 	MONDO:0005027	epilepsy	up-regulated	RT-qPCR; Microarray	"This study identifies human circ288/hsa_circ_0000288 as a serum circRNA elevated in epileptic patients in remission and as a candidate therapeutic RNA for epilepsy. In mouse and in vitro epilepsy models, circ288 protects neurons, supports hippocampal neurogenesis, reduces aberrant neuronal migration, suppresses epileptogenesis-related seizures and discharges, and improves cognitive and mood deficits. Mechanistically, circ288 directly binds and stabilizes the RBP caprin1, leading to increased NR3B mRNA levels through a proposed circ288-caprin1-NR3B pathway; exosome-encapsulated circ288 also shows anti-epileptic activity."	0.782
39967473	Journal of biochemical and molecular toxicology	2025	"Circ_0070934 Regulates the Proliferation, Metastasis, and Epithelial-Mesenchymal Transition of Colorectal Cancer Cells by Targeting miR-203a-3p/HOXA13 Axis."	hsa_circ_0070934	circ_0070934 			colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circ_0070934 is up-regulated in colorectal cancer tissues and cells and high expression is associated with aggressive clinicopathologic features and poor prognosis. Functionally, circ_0070934 promotes CRC cell proliferation, migration, invasion, EMT, and xenograft tumor growth. Mechanistically, it acts as a sponge for miR-203a-3p to regulate the downstream HOXA13 axis."	0.8557
39970724	Biosensors & bioelectronics	2025	Lighting up three-dimensional nanolantern for circular RNA imaging and precise gene therapy.		circCDYL	hsa_circ_CDYL	CDYL	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"This study used circCDYL as a cancer-associated target for a DNA nanolantern-based imaging and gene therapy platform. circCDYL was up-regulated in breast cancer tissues and cancer cell lines, and its presence triggered strand-displacement assembly of nanolantern concatemers with on-demand siRNA release to silence VEGF mRNA and induce apoptosis in MCF-7 cells. Clinically, circCDYL quantification by the nanolantern method and qRT-PCR discriminated breast cancer tissues from healthy tissues with high accuracy."	0.6762
39973750	"Arteriosclerosis, thrombosis, and vascular biology"	2025	SRSF4-Associated ca-circFOXP1 Regulates Hypoxia-Induced PASMC Proliferation by the Formation of R Loop With Host Gene.	mmu_circ_0013639	ca-circFOXP1 	mmu_circ_FOXP1	FOXP1	pulmonary hypertension 	MONDO:0005149	pulmonary hypertension	up-regulated	RT-qPCR; ISH; Microarray	"ca-circFOXP1 is up-regulated in hypoxic PH models and hypoxic PASMCs. It promotes PASMC proliferation, cell cycle progression, migration, pulmonary vascular remodeling, and fibrosis by forming an m6A-dependent R loop with the FOXP1 host gene, reducing FOXP1 expression and enhancing Smad2 phosphorylation; SRSF4 promotes ca-circFOXP1 biogenesis through FOXP1 pre-mRNA splicing."	0.8491
39976889	Biochemical genetics	2026	"Study the Expression of Two Circular RNAs, hsa_circ_0003227 and hsa_circ_0001666, in the Primary Breast Cancer Cell Line BT-20 and the Metastatic Breast Cancer Cell Line MCF-7."	hsa_circ_0001666	hsa_circ_000742 	hsa_circ_FAM120B	FAM120B	breast cancer	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	"hsa_circ_0001666 was experimentally measured by RT-qPCR in MCF-10A, BT-20, and MCF-7 cells and was significantly down-regulated in breast cancer and metastatic cell lines compared with normal breast epithelial cells. The study suggests it may serve as an early diagnostic biomarker for breast cancer, although mechanistic and clinical validation were not performed."	0.1155
39976889	Biochemical genetics	2026	"Study the Expression of Two Circular RNAs, hsa_circ_0003227 and hsa_circ_0001666, in the Primary Breast Cancer Cell Line BT-20 and the Metastatic Breast Cancer Cell Line MCF-7."	hsa_circ_0003227	hsa_ circ_0003227	hsa_circ_NUP155	NUP155	breast cancer	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	"hsa_circ_0003227 was experimentally measured by RT-qPCR in MCF-10A, BT-20, and MCF-7 cells and was significantly down-regulated in breast cancer and metastatic cell lines compared with normal breast epithelial cells. The study proposes it as a potential diagnostic biomarker for breast cancer, but its molecular mechanism and clinical performance were not validated."	0.1155
39982754	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2025	Circ-Sirt6 promotes the stability and expression of m6A modified Sirt6 mRNA by recruiting IGF2BP2.	hsa_circ_0048584		hsa_circ_SIRT6	SIRT6	Coronary artery disease 	MONDO:0005010	coronary artery disorder	down-regulated	RT-qPCR; RNA-seq; Microarray	"Circ-Sirt6 is downregulated in PDGF-BB-induced proliferative VSMCs and rat carotid artery balloon injury. Its overexpression inhibits VSMC proliferation, migration, phenotypic switching, and neointimal hyperplasia by recruiting IGF2BP2 to enhance m6A modification, stability, and expression of Sirt6 mRNA. The study suggests circ-Sirt6 as a potential biological target for CAD-related vascular pathology."	0.82
39982754	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2025	Circ-Sirt6 promotes the stability and expression of m6A modified Sirt6 mRNA by recruiting IGF2BP2.			rno_circ_Sirt6	Sirt6	Coronary artery disease 	MONDO:0005010	coronary artery disorder	down-regulated	RT-qPCR; RNA-seq; Microarray	"Circ-Sirt6 is downregulated in PDGF-BB-induced proliferative VSMCs and rat carotid artery balloon injury. Its overexpression inhibits VSMC proliferation, migration, phenotypic switching, and neointimal hyperplasia by recruiting IGF2BP2 to enhance m6A modification, stability, and expression of Sirt6 mRNA. The study suggests circ-Sirt6 as a potential biological target for CAD-related vascular pathology."	0.82
39986587	"Journal of stomatology, oral and maxillofacial surgery"	2025	CircPVT1 promotes periodontitis progression by regulating miR-24-3p/HIF1AN pathway.	hsa_circ_0085536	CircPVT1	hsa_circ_PVT1	PVT1	periodontitis	MONDO:0005076	periodontitis	up-regulated	RT-qPCR	"circPVT1 is up-regulated in gingival tissues from periodontitis patients and in LPS-treated PDLCs. The study supports that circPVT1 promotes periodontitis progression by sponging miR-24-3p, regulating HIF1AN, and modulating NRF-2/HO-1-related inflammation and oxidative stress responses."	0.7936
39987303	Archives of dermatological research	2025	Hypoxia-induced adipose derived stem cells-derived exosomes promote diabetic wound healing through circ-0001747/miR-199a-5p/HIF-1alpha axis.	mmu_circ_0001747	circ-0001747 			diabetic foot ulcers 	MONDO:0000960	diabetic peripheral angiopathy	up-regulated	RT-qPCR; RNA-seq	"This study identifies circ-0001747 as an exosomal circRNA enriched in hypoxia-induced ADSC-derived exosomes. circ-0001747 promotes diabetic wound healing by sponging miR-199a-5p to increase HIF1alpha expression, thereby enhancing angiogenesis and reducing ROS production and apoptosis in endothelial cells and DFU mouse wounds."	0.7164
39987565	Molecular carcinogenesis	2025	CircDIAPH1 Promotes Liver Metastasis and Development of Colorectal Cancer by Initiation of CEACAM6 Expression.	hsa_circ_0074323	circDIAPH1 	hsa_circ_DIAPH1	DIAPH1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circDIAPH1 (hsa_circ_0074323) is highly expressed in CRC liver metastasis-associated samples and is proposed as a biomarker for CRLM. Functionally, circDIAPH1 promotes CRC cell proliferation, invasion, migration, tumor growth and liver metastasis while suppressing apoptosis. Mechanistically, circDIAPH1 recruits FOXA1 to activate CEACAM6 expression, and its own expression is regulated by the transcription factor BRD4."	0.8177
39988878	Archives of physiology and biochemistry	2025	Circular RNA NXN (circNXN) promotes diabetic retinopathy by regulating the miR-338-3p/FGFR1 axis.	hsa_circ_0041177	circular RNA NXN 	hsa_circ_NXN	NXN	diabetic retinopathy 	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR	"circNXN is significantly upregulated in diabetic retinopathy patient serum and in high glucose-treated hRMECs. Functionally, circNXN promotes hRMEC proliferation, migration, and angiogenesis while inhibiting apoptosis, and its knockdown alleviates retinal pathological changes in an STZ-induced diabetic retinopathy model. Mechanistically, circNXN functions as a ceRNA sponge for miR-338-3p to increase FGFR1 expression."	0.795
39994492	Biotechnology and applied biochemistry	2025	Plasma Exosomal circRNAs as Potential Biomarkers for Patients with Septic Shock-Induced Acute Kidney Injury.		circ-Ttc3	hsa_circ_Ttc3		septic shock-induced acute kidney injury 	MONDO:0005229	bacterial infectious disease with sepsis	down-regulated	RT-qPCR	circ-Ttc3 was significantly downregulated in plasma exosomes from patients with sepsis-induced AKI and also reduced in HK-2 cells treated with AKI-derived exosomes. The study suggests that circ-Ttc3 may have a protective role related to apoptosis and oxidative stress regulation and may serve as a candidate biomarker or therapeutic target.	0.2995
39994492	Biotechnology and applied biochemistry	2025	Plasma Exosomal circRNAs as Potential Biomarkers for Patients with Septic Shock-Induced Acute Kidney Injury.		circ-Fryl	hsa_circ_Fryl		septic shock-induced acute kidney injury 	MONDO:0005229	bacterial infectious disease with sepsis	down-regulated	RT-qPCR	"circ-Fryl was significantly downregulated in plasma exosomes from patients with sepsis-induced AKI. The study identifies it as one of four exosomal circRNAs potentially involved in cell proliferation, apoptosis, and oxidative stress regulation and as a candidate biomarker or therapeutic target."	0.2995
39994492	Biotechnology and applied biochemistry	2025	Plasma Exosomal circRNAs as Potential Biomarkers for Patients with Septic Shock-Induced Acute Kidney Injury.	hsa_circ_0091702	circ_0091702			septic shock-induced acute kidney injury 	MONDO:0005229	bacterial infectious disease with sepsis	down-regulated	RT-qPCR	"circ_0091702 was significantly downregulated in plasma exosomes from patients with sepsis-induced AKI. The study proposes that it may participate in regulation of proliferation, apoptosis, and oxidative stress and may be useful as a candidate biomarker or therapeutic target."	0.2995
39994492	Biotechnology and applied biochemistry	2025	Plasma Exosomal circRNAs as Potential Biomarkers for Patients with Septic Shock-Induced Acute Kidney Injury.		circ-TLK1	hsa_circ_TLK1	TLK1	septic shock-induced acute kidney injury 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR	"circ-TLK1 showed a non-significant increasing trend in plasma exosomes and was significantly elevated in HK-2 cells exposed to sepsis-induced AKI exosomes. The study suggests that circ-TLK1 may contribute to oxidative stress, inflammation, and apoptosis, potentially through the HMGB1/NF-kappaB pathway, and may be a candidate biomarker or therapeutic target."	0.2995
39997071	Journal of immunoassay & immunochemistry	2025	Estimate of circRNAs and microRNAs synergies on clinical advance of psoriasis.		CircRNA0045272 	hsa_circ_ERN1	ERN1	plaque psoriasis 	MONDO:0005083	psoriasis	up-regulated	RT-qPCR	"circRNA0045272 (ERN1) was significantly up-regulated in blood from plaque psoriasis patients and showed the best diagnostic performance among studied circRNAs. It was positively correlated with microRNA 181, suggesting a possible circRNA-miRNA regulatory relationship in psoriasis, though the mechanism was not experimentally validated beyond expression and correlation analyses."	0.4187
39997071	Journal of immunoassay & immunochemistry	2025	Estimate of circRNAs and microRNAs synergies on clinical advance of psoriasis.		CircRNA0084764 	hsa_circ_EYA1	EYA1	plaque psoriasis 	MONDO:0005083	psoriasis	down-regulated	RT-qPCR	"circRNA0084764 (EYA1) was significantly down-regulated in blood from plaque psoriasis patients and showed diagnostic value for psoriasis. It was positively correlated with microRNA 93 and microRNA 181, suggesting a possible circRNA-miRNA regulatory role in psoriasis-related immune and inflammatory dysregulation."	0.4187
39997071	Journal of immunoassay & immunochemistry	2025	Estimate of circRNAs and microRNAs synergies on clinical advance of psoriasis.		CircRNA000102 	hsa_circ_AKNAD1	AKNAD1	plaque psoriasis 	MONDO:0005083	psoriasis	down-regulated	RT-qPCR	"circRNA000102 (AKNAD1) was significantly down-regulated in blood from plaque psoriasis patients and showed diagnostic value for psoriasis. Unlike circRNA0045272 and circRNA0084764, no specific miRNA correlation was reported for circRNA000102 in this study, so its mechanistic role remains less defined."	0.4187
40007179	The New phytologist	2025	A novel peptide encoded by a rice circular RNA confers broad-spectrum disease resistance in rice plants.		circRNA 351 	osa_circ_WRKY9	WRKY9	rice stripe mosaic virus infection 	Plant diseases		up-regulated	RT-qPCR; Northern Blot; RNA-seq	"circ-WRKY9 is an OsWRKY9-derived rice circRNA upregulated after RSMV infection. It encodes the small peptide WRKY9-88aa through an IRES-dependent translation mechanism, and this peptide enhances broad-spectrum plant disease resistance by promoting ROS production, cell death-related responses and defense gene regulation."	0.6817
40010553	Journal of ethnopharmacology	2025	Jianpi Qingre Tongluo Prescription (Huangqin Qingrechubi Capsule) alleviates inflammation and hypercoagulability by inhibiting the JAK2/STAT3 pathway via CircRNA 104633 downregulation in gouty arthritis.		CircRNA 104633			gouty arthritis 	MONDO:0005393	gout	up-regulated	RT-qPCR	"CircRNA 104633 is up-regulated in PBMCs from patients with gouty arthritis and is positively associated with inflammatory and coagulation-related clinical indexes. Functionally, CircRNA 104633 promotes FLS viability, inflammation, and hypercoagulability by activating the JAK2/STAT3 pathway, while HQC treatment counteracts these effects by reducing CircRNA 104633 expression."	0.6474
40020806	International journal of biological macromolecules	2025	NSUN2-mediated m5C modification of circFAM190B promotes lung cancer progression by inhibiting cellular autophagy.	hsa_circ_0006956	circFAM190B 	hsa_circ_FAM190B	FAM190B	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; RNA-seq	"circFAM190B is an up-regulated human circRNA in lung cancer and is associated with tumor size, stage, diagnostic potential, and poorer overall survival. NSUN2-mediated m5C modification stabilizes circFAM190B, which promotes lung cancer progression by binding SFN, reducing SFN ubiquitination, activating the SFN/mTOR/ULK1 pathway, and inhibiting cellular autophagy."	0.9047
40022852	Molecular immunology	2025	circSTIL mediates pirarubicin inhibiting the malignant phenotype of triple-negative breast cancer and acts as a biomarker in plasma exosomes.	hsa_circ_0000069	circSTIL	hsa_circ_STIL	STIL	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"circSTIL is an up-regulated human circRNA in TNBC cell lines, TNBC tissues, and plasma exosomes. Functionally, circSTIL promotes proliferation, migration, and invasion while inhibiting apoptosis in MDA-MB-231 cells, and its overexpression partially reverses the anti-malignant effects of pirarubicin. Clinically, plasma exosomal circSTIL may help distinguish TNBC from non-TNBC and high expression is associated with poorer DFS."	0.8319
40042790	Esophagus : official journal of the Japan Esophageal Society	2025	Circ_DLG1 facilitates cell proliferation and metastasis of esophageal squamous cell carcinoma via upregulating MAP3K9.	hsa_circ_0007203	circ_DLG1 	hsa_circ_DLG1	DLG1	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"Circ_DLG1 is up-regulated in ESCC tissues, plasma, and cell lines, and high expression is associated with poorer overall survival. Functionally, circ_DLG1 promotes ESCC proliferation, migration, invasion, metastasis, and xenograft tumor growth. Mechanistically, it sponges miR-338-3p to increase MAP3K9 expression and activate the p38/ERK pathway."	0.8198
40049089	International immunopharmacology	2025	Administration of hypoxic pretreated adipose-derived mesenchymal stem cell exosomes promotes spinal cord repair after injury via delivery of circ-Astn1 and activation of autophagy.	mmu_circ_0000101	circ-Astn1	mmu_circ_Astn1	Astn1	spinal cord injury 	MONDO:0043797	spinal cord injury	down-regulated	RT-qPCR; RNA-seq	"This study identifies exosomal circ-Astn1 as a protective circRNA in spinal cord injury repair. HExo-delivered circ-Astn1 promotes autophagy and reduces neuroinflammation and apoptosis through the miR-138-5p/Atg7 axis, thereby enhancing functional recovery after SCI."	0.7216
40052890	"Iranian journal of allergy, asthma, and immunology"	2025	Analyzing the Role of CircSnx5 in an Animal Model of Multiple Sclerosis.	mmu_circ_0001081	circSnx5	mmu_circ_Snx5	Snx5	multiple sclerosis 	MONDO:0005301	multiple sclerosis	up-regulated	RT-qPCR	"This study found that mouse circSnx5 is up-regulated in EAE lumbar spinal cord at the disease peak and correlates positively with inflammatory cytokine expression. Its expression decreases during splenocyte activation and during differentiation of na_ve CD4+ T cells into Th1, Th17, and Treg cells, suggesting a role in autoimmune neuroinflammation and T cell-related inflammatory regulation."	0.3956
40055930	Iranian journal of immunology : IJI	2025	circ_0001006 Promotes Immune Escape in Non-small Cell Lung Cancer by Regulating the miR-320a/PD-L1 Axis.	hsa_circ_0001006	circ_0001006			Non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0001006 is up-regulated in NSCLC tissues and cell lines and high expression predicts poorer overall survival. Functionally, circ_0001006 promotes NSCLC proliferation, migration, invasion, and immune escape by sponging miR-320a and regulating PD-L1 expression/secretion, thereby suppressing CD8+ T cell activity."	0.7365
40058671	Molecular and cellular probes	2025	Down-regulated circ_0001853 inhibits lipopolysaccharide-induced endometritis progression via sponging miR-34c-5p.	hsa_circ_0001853	circ_0001853 			endometritis	MONDO:0000918	endometritis	up-regulated	RT-qPCR	"circ_0001853 is up-regulated in serum from patients with endometritis and in LPS-stimulated human endometrial epithelial cells. Its silencing increases miR-34c-5p, promotes epithelial cell proliferation, reduces apoptosis, and suppresses inflammatory cytokines, suggesting a diagnostic and pathogenic role in endometritis."	0.7507
40063163	Human cell	2025	Circ_0090100 induces AHNAK expression to inhibit trophoblast cell proliferation and invasion and accelerate cell apoptosis by segregating miR-139-5p in preeclampsia.	hsa_circ_0090100	circ_0090100			preeclampsia 	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR	"circ_0090100 is upregulated in placental tissues from patients with preeclampsia. It suppresses trophoblast cell proliferation and invasion while promoting apoptosis by sponging miR-139-5p and increasing AHNAK expression, suggesting a circ_0090100/miR-139-5p/AHNAK regulatory axis in PE-related placental dysfunction."	0.7795
40085314	Biochemical genetics	2026	CircMMP11 is a Potential Recurrence Biomarker and Facilitates Progression of Esophageal Squamous Cell Carcinoma.	hsa_circ_0062558	circMMP11 	hsa_circ_MMP11	MMP11	Esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"circMMP11 is up-regulated in ESCC tissues and cells, especially in patients with postoperative recurrence/metastasis. It promotes ESCC cell proliferation, migration, and invasion, at least partly by regulating miR-671-5p, and may serve as a biomarker for predicting postoperative recurrence/metastasis."	0.8111
40090540	Experimental cell research	2025	CircTHADA regulates endothelial cell pyroptosis in diabetic retinopathy through miR-494-3p/CASP1/GSDMD-N/IL-1beta pathway.	hsa_circ_0007086	circTHADA	hsa_circ_THADA 	THADA	diabetic retinopathy 	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR; Microarray	circTHADA is up-regulated in high-glucose HRMECs and STZ-induced diabetic retinopathy mouse retinas. It promotes endothelial cell pyroptosis and retinal vascular dysfunction by sponging miR-494-3p and enhancing CASP1-mediated pyroptosis signaling involving GSDMD-N and IL-1beta.	0.7446
40090540	Experimental cell research	2025	CircTHADA regulates endothelial cell pyroptosis in diabetic retinopathy through miR-494-3p/CASP1/GSDMD-N/IL-1beta pathway.	mmu_circ_0007060	circTHADA	mmu_circ_THADA	THADA	diabetic retinopathy 	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR; Microarray	circTHADA is up-regulated in high-glucose HRMECs and STZ-induced diabetic retinopathy mouse retinas. It promotes endothelial cell pyroptosis and retinal vascular dysfunction by sponging miR-494-3p and enhancing CASP1-mediated pyroptosis signaling involving GSDMD-N and IL-1beta.	0.7446
40090540	Experimental cell research	2025	CircTHADA regulates endothelial cell pyroptosis in diabetic retinopathy through miR-494-3p/CASP1/GSDMD-N/IL-1beta pathway.		hsa_circ_00021205 	hsa_circ_WEE1	WEE1	diabetic retinopathy 	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR; Microarray	"circWEE1 was identified among top differentially expressed circRNA candidates and was validated by RT-qPCR as up-regulated in HG-treated HRMECs. Functional screening showed that siRNA against circWEE1 did not reverse HG-induced CASP1 elevation, so the study did not pursue a mechanism for circWEE1."	0.3684
40090573	Cancer letters	2025	CircRUNX1 enhances the Warburg effect and immune evasion in non-small cell lung cancer through the miR-145/HK2 pathway.	hsa_circ_0002360	circRUNX1 	hsa_circ_RUNX1	RUNX1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circRUNX1 is up-regulated in NSCLC tissues and cells and high expression is associated with advanced clinicopathological features and poor prognosis. Mechanistically, circRUNX1 sponges miR-145 to increase HK2 expression, enhancing glycolysis, lactate production and the Warburg effect. This metabolic reprogramming promotes Treg infiltration and immune evasion while supporting NSCLC proliferation, migration and tumor growth."	0.8661
40092137	American journal of translational research	2025	"MiR-145-5p inhibits proliferation of hepatocellular carcinoma, acting through PAI-1."		Circular RNA PVT1 	hsa_circ_PVT1	PVT1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circPVT1 is up-regulated in HCC tissues and cell lines. It directly binds miR-145-5p and promotes HCC cell proliferative ability and clone formation, likely through the circPVT1/miR-145-5p/PAI-1 regulatory axis, suggesting diagnostic or therapeutic relevance."	0.6369
40094400	Cancer biomarkers : section A of Disease markers	2024	"Hsa_circ_0002346 inhibits proliferation, invasion, and migration of breast cancer cells and promotes apoptosis: A novel potential biomarker for breast cancer."	hsa_circ_0002346	hsa_-circ_0002346 			breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0002346 is downregulated in breast cancer tissues and cell lines. Functional knockdown experiments indicate that it acts as a tumor-suppressive circRNA by inhibiting proliferation, colony formation, migration, invasion and EMT-associated changes while promoting apoptosis. Clinically, its expression is associated with lymph node metastasis, suggesting biomarker potential."	0.6599
40095292	International journal of rheumatic diseases	2025	Unraveling the Dual Role of circ-CBLB and ETS-1 in Rheumatoid Arthritis: Biomarkers and Therapeutic Targets.		circ-CBLB 	hsa_circ_CBLB		rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	down-regulated	RT-qPCR	"This study identifies circ-CBLB as downregulated in PBMCs and RA-FLSs in rheumatoid arthritis. Functionally, circ-CBLB overexpression suppresses RA-FLS viability and migration, promotes apoptosis, affects cell-cycle distribution, and shifts cytokine expression toward a less inflammatory profile. Mechanistically, circ-CBLB interacts with the transcription factor ETS-1 in a bidirectional regulatory loop and may serve as a biomarker for high RA disease activity."	0.6218
40095343	Molecular neurobiology	2025	EIF4A3-Induced circ_0029941 Promotes Astrocyte Activation Through Enhancing Autophagy via miR-224-5p/NFAT5 Axis.	hsa_circ_0029941	circ_0029941	hsa_circ_PDS5B	PDS5B	acute ischemic stroke 	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR	"circ_0029941 is up-regulated in AIS patients, tMCAO mouse models and OGD/R-induced astrocytes. EIF4A3 enhances circ_0029941 expression, and circ_0029941 functions as a miR-224-5p sponge to increase NFAT5, thereby promoting ATG5-mediated autophagy and astrocyte activation. Silencing circ_0029941 alleviates brain infarction and neurological deficits in tMCAO mice, suggesting therapeutic potential in AIS."	0.7944
40096161	Journal of biochemical and molecular toxicology	2025	Circ_0022587 Regulates Tumor Properties of Human Breast Cancer Cells by Targeting miR-335-5p/Phosphoglycerate Kinase 1 Pathway.	hsa_circ_0022587	circ_0022587 	hsa_circ_SLC3A2	SLC3A2	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circ_0022587 is upregulated in breast cancer tissues and cells, and high expression is associated with poor patient prognosis. Functionally, circ_0022587 promotes BC cell viability, proliferation, invasion, angiogenesis, glycolysis and in vivo tumor growth while suppressing apoptosis. Mechanistically, it acts through the circ_0022587/miR-335-5p/PGK1 regulatory axis."	0.8202
40099364	Circulation	2025	"A Novel Hidden Protein p-414aa Encoded by circSETD2(14,15) Inhibits Vascular Remodeling."	hsa_circ_0065149		hsa_circ_SETD2	SETD2	vascular remodeling 	MONDO:0005385	vascular disorder	down-regulated	RT-qPCR; Microarray	"circSETD2(14,15), also identified as hsa_circ_0065149, is reduced in human atherosclerotic arteries and PDGF-BB-induced proliferative HASMCs. It encodes the hidden protein p-414aa, which binds HuR and reduces HuR-mediated stabilization of C-FOS mRNA, thereby suppressing VSMC proliferation, migration, phenotypic switching, neointimal hyperplasia, and vascular remodeling."	0.8213
40099691	Molecular carcinogenesis	2025	Circ_0044362 Facilitates the Progression of Epithelial Ovarian Cancer via Enhancing HOXB4 Transcription to Activate the RUNX1/IGFBP3 Axis.	hsa_circ_0044362	circ_0044362	hsa_circ_HOXB4	HOXB4	epithelial ovarian cancer 	MONDO:0005140	ovarian carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ_0044362 is a HOXB4-derived exon-intron circRNA that is up-regulated in ovarian cancer tissues. It promotes ovarian cancer cell proliferation, colony formation, migration, invasion, and xenograft tumor growth by recruiting U1 snRNP to enhance HOXB4 transcription and activate the HOXB4/RUNX1/IGFBP3 axis. The study suggests circ_0044362 as a potential therapeutic target for ovarian cancer."	0.8684
40105157	Technology and health care : official journal of the European Society for Engineering and Medicine	2025	Cancer-associated fibroblasts derived-exosomal circ_0076535 promotes esophageal squamous cell carcinoma progression.	hsa_circ_0076535	circ_0076535			esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"CAF-derived exosomal circ_0076535 is enriched in CAF exosomes and transferred into ESCC cells, where it promotes proliferation, migration, invasion, EMT, and tumor formation. Mechanistically, it functions as a miR-145-5p sponge and activates the NF-__B pathway, suggesting potential value as a biomarker or therapeutic target in ESCC."	0.6542
40116106	Discovery medicine	2025	Analysis of hsa_circ_0006459 and hsa_circ_0015962 Expression in Peripheral Blood Mononuclear Cells of Dengue-Infected Patients and Healthy Donors.	hsa_circ_0006459				Dengue virus infection 	MONDO:0005502	dengue disease	dysregulated	RT-qPCR	"This study measured hsa_circ_0006459 expression in PBMC from DENV-positive patients and healthy donors by RT-qPCR during a 28-day follow-up. hsa_circ_0006459 showed possible expression changes, especially at diagnosis, but its kinetics were variable among patients and not correlated with viral load or symptom resolution, limiting its biomarker utility."	0.429
40116106	Discovery medicine	2025	Analysis of hsa_circ_0006459 and hsa_circ_0015962 Expression in Peripheral Blood Mononuclear Cells of Dengue-Infected Patients and Healthy Donors.	hsa_circ_0015962				Dengue virus infection 	MONDO:0005502	dengue disease	dysregulated	RT-qPCR	"This study measured hsa_circ_0015962 expression in PBMC from DENV-positive patients and healthy donors by RT-qPCR during a 28-day follow-up. hsa_circ_0015962 was often undetected in patients, showed a statistically significant difference at diagnosis compared with healthy donors, and displayed fluctuating individual-specific kinetics, so its biomarker role remains uncertain."	0.429
40116418	General physiology and biophysics	2025	Co-delivery of circCDR1 and temozolomide with hyaluronic acid-chitosan nanoparticles inhibits glioma progression.		circCDR1 	hsa_circ_CDR1	CDR1	glioma 	MONDO:0021042	glioma	down-regulated	RT-qPCR	"circCDR1 is down-regulated in glioma tissues and cells, and low circCDR1 expression is associated with poorer overall survival. Functionally, circCDR1 suppresses glioma progression by sponging miR-890 and up-regulating GJB6, thereby inhibiting proliferation, migration and invasion while promoting apoptosis. HA-CS nanoparticles co-delivering circCDR1 and TMZ enhanced anti-glioma effects in vitro and in a LN229 xenograft model."	0.8486
40116870	Naunyn-Schmiedeberg's archives of pharmacology	2025	Dioscin alleviates the dysfunction of fibroblast-like synoviocytes by circ_0008267/miR-942-5p/FKBP5 axis during rheumatoid arthritis.	hsa_circ_0008267	circ_0008267	hsa_circ_SDHAP2	SDHAP2	rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; Microarray	"circ_0008267 is up-regulated in RA synovial tissues and RA-FLS. It promotes RA-FLS dysfunction by sponging miR-942-5p to regulate FKBP5, thereby enhancing proliferation, invasion, migration, and inflammatory cytokine release while suppressing apoptosis. Dioscin reduces circ_0008267 expression and alleviates RA-FLS dysfunction through the circ_0008267/miR-942-5p/FKBP5 axis."	0.78
40117336	Journal of biochemical and molecular toxicology	2025	A Novel Circ_0004104/MiR-493-5p/SYPL1 Cascade Contributes to Colorectal Cancer Progression.	hsa_circ_0004104	circ_0004104	hsa_circ_SPARC	SPARC	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0004104 is upregulated in CRC tissues and cell lines, and high expression is associated with poor prognosis. It promotes malignant CRC progression by sponging miR-493-5p to increase SYPL1 expression, thereby enhancing proliferation, migration, invasion, EMT-like marker changes, and xenograft tumor growth while reducing apoptosis."	0.8239
40129360	Current eye research	2025	The Role of circFAM53B in Regulating Choroidal Vascular Function in Pathological Myopia.		circRNA8996		FAM53B	pathological myopia 	MONDO:0001384	myopia	up-regulated	RT-qPCR; RNA-seq	"circFAM53B is upregulated in hypoxic/oxidative choroidal endothelial injury models and in form-deprivation myopic guinea pig eye tissues. It contributes to choroidal vascular dysfunction in pathological myopia, likely through a ceRNA mechanism involving miR-1248 and THBS1, while circFAM53B knockdown improves endothelial viability, migration and tubulogenesis and reduces apoptosis."	0.6964
40129360	Current eye research	2025	The Role of circFAM53B in Regulating Choroidal Vascular Function in Pathological Myopia.		circRNA8996		FAM53B	pathological myopia 	MONDO:0001384	myopia	up-regulated	RT-qPCR; RNA-seq	"circFAM53B is upregulated in hypoxic/oxidative choroidal endothelial injury models and in form-deprivation myopic guinea pig eye tissues. It contributes to choroidal vascular dysfunction in pathological myopia, likely through a ceRNA mechanism involving miR-1248 and THBS1, while circFAM53B knockdown improves endothelial viability, migration and tubulogenesis and reduces apoptosis."	0.6964
40135563	Molecular carcinogenesis	2025	Hsa_circ_0000231 Accelerates Cell Autophagy and Promotes Cell Proliferation and Invasion of Colorectal Cancer via miR-140-3p/Bcl-2 Axis.	hsa_circ_0000231	circ_0000231			colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0000231 is upregulated in colorectal cancer tissues and high expression is associated with poor prognosis. Functionally, circ_0000231 promotes CRC cell proliferation, migration, invasion, xenograft growth, and autophagy. Mechanistically, it sponges miR-140-3p to regulate Bcl-2, with Bcl-2-associated autophagy involving Atg12."	0.8051
40139398	International journal of cardiology	2025	Plasma expression level of Hsa_circ_0099734 is associated with atrial fibrillation and its poor prognosis.	hsa_circ_0099734		hsa_circ_PCCA	PCCA	atrial fibrillation 	MONDO:0004981	atrial fibrillation	up-regulated	RT-qPCR; RNA-seq	"This study identifies elevated plasma hsa_circ_0099734 as associated with increased risk of atrial fibrillation and poor prognosis in AF patients. High hsa_circ_0099734 expression independently predicted stroke and all-cause mortality, and its addition to the CHA 2 DS 2 -VA score improved prognostic risk stratification."	0.4992
40152245	Toxicological sciences : an official journal of the Society of Toxicology	2025	SETBP1-R54P mutation promotes malignant transformation of cadmium-induced 16HBE cells by down-regulating circ_0007095 expression.	hsa_circ_0007095	circ_0007095	hsa_circ_SETBP1	SETBP1	Cd carcinogenesis 	MONDO:0004992	cancer	down-regulated	RT-qPCR; RNA-seq	"circ_0007095 is a human SETBP1-derived circRNA that is stably down-regulated during Cd-induced malignant transformation of 16HBE cells. Functionally, circ_0007095 suppresses proliferation, cell-cycle progression, migration, invasion and xenograft tumor growth. Mechanistically, SETBP1-R54P mutation activates the KLF4-PFKP axis, leading to PFKP-associated degradation and reduced stability of circ_0007095."	0.8038
40154160	Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy	2025	Targeting cTRIP12 counteracts ferroptosis resistance and augments sensitivity to immunotherapy in pancreatic cancer.	hsa_circ_0003273		hsa_circ_TRIP12	TRIP12	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"cTRIP12 (hsa_circ_0003273) is an upregulated TRIP12-derived circRNA in ferroptosis-resistant PDAC and is associated with poor prognosis. It acts as a protein scaffold linking PERK and OGT, enhancing OGT-mediated O-GlcNAcylation of FTH and HGS, which increases FTH and PD-L1 protein levels, suppresses ferroptosis, promotes immune evasion, and supports resistance to ferroptosis- and immunotherapy-based treatment."	0.8961
40154160	Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy	2025	Targeting cTRIP12 counteracts ferroptosis resistance and augments sensitivity to immunotherapy in pancreatic cancer.	hsa_circ_0008562				pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0008562 was identified by circRNA-seq and qRT-PCR as one of two circRNAs related to ferroptosis resistance in PDAC clinical samples. The paper did not further investigate its host gene, cellular localization, interacting partners, functional role, mechanism, or prognostic significance."	0.4685
40160441	Cytotechnology	2025	Blocking circular RNA FNDC3B induces fibroblast-like synoviocytes dysfunction to ameliorate rheumatoid arthritis through regulating the miR-125a-5p-Hexokinase2 axis.		circFNDC3B 	hsa_circ_FNDC3B	FNDC3B	Rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"circFNDC3B is upregulated in human RA fibroblast-like synoviocytes. It acts as a ceRNA by sponging miR-125a-5p, thereby regulating HK2, enhancing glucose metabolism, and reducing oxidative stress-induced cell injury/apoptosis in FLSs-RA. The study suggests circFNDC3B as a potential diagnostic biomarker and therapeutic target for rheumatoid arthritis."	0.7032
40164374	Experimental eye research	2025	"Construction of a competing endogenous RNA regulatory network in pterygium and role of hsa_circ_0081682 in fibroblast proliferation, migration, and apoptosis."	hsa_circ_0081682				pterygium	MONDO:0005085	pterygium	down-regulated	RT-qPCR; Microarray	"hsa_circ_0081682 was down-regulated in pterygium tissues and primary human pterygium fibroblasts. Functional knockdown experiments indicate that this circRNA restrains fibroblast proliferation and migration and supports apoptosis, suggesting a protective or inhibitory role in pterygium progression and potential diagnostic value."	0.6829
40164764	Nature biotechnology	2026	Circular RNA aptamers targeting neuroinflammation ameliorate Alzheimer disease phenotypes in mouse models.			hsa_circ_POLR2A	POLR2A	Alzheimer disease 	MONDO:0004975	Alzheimer disease	unknown	RT-qPCR; Northern Blot	"Human circPOLR2A(9,10) was delivered by AAV as a ds-cRNA aptamer therapy in AD mouse models. It inhibits PKR activation, reduces neuroinflammation and AD-related toxic protein accumulation, protects neurons, and improves memory-related phenotypes."	0.5229
40164764	Nature biotechnology	2026	Circular RNA aptamers targeting neuroinflammation ameliorate Alzheimer disease phenotypes in mouse models.			hsa_circ_CAMSAP1	CAMSAP1	Alzheimer disease 	MONDO:0004975	Alzheimer disease	unknown	RT-qPCR; Northern Blot	"Human circCAMSAP1(2,3) was used as an independent ds-cRNA aptamer to test whether therapeutic effects were not sequence-specific to circPOLR2A. AAV delivery of circCAMSAP1(2,3) reduced PKR activation and neuroinflammation, alleviated AD-related pathology, and improved learning and memory in 5xFAD and PS19 mouse models."	0.4636
40165503	Journal of biochemical and molecular toxicology	2025	Tumor-Derived Exosomal circ_0020095 Promotes Colon Cancer Cell Proliferation and Metastasis by Inhibiting M1 Macrophage Polarization.	hsa_circ_0020095	circ_0020095	hsa_circ_ATRNL1	ATRNL1	colon cancer 	MONDO:0021063	malignant colon neoplasm	up-regulated	RT-qPCR	"circ_0020095 is up-regulated in colon cancer tissues, cells and CC cell-derived exosomes, and high expression is associated with poorer survival and more aggressive clinicopathological features. Functionally, tumor-derived exosomal circ_0020095 promotes CC proliferation, migration, invasion, metastasis and tumor growth by suppressing M1 macrophage polarization. Mechanistically, circ_0020095 competitively binds IGF2BP1 and blocks IGF2BP1 binding to IRAK1 3¡äUTR, reducing IRAK1 expression and thereby regulating the IGF2BP1/IRAK1 axis."	0.8349
40175625	Leukemia	2025	CircTADA2A stabilizes p53 via interacting with TRIM28 and suppresses the maintenance of FLT3-ITD acute myeloid leukemia.	hsa_circ_0006220	circTADA2A	hsa_circ_TADA2A	TADA2A	FLT3-ITD acute myeloid leukemia 	MONDO:0017858	acute erythroid leukemia	down-regulated	RT-qPCR; Microarray	"CircTADA2A is downregulated in FLT3-ITD AML and functions as a tumor-suppressive circRNA. It binds TRIM28 to disrupt TRIM28/MDM2 complex formation, reduces p53 ubiquitination and degradation, activates the p53 pathway, suppresses AML cell proliferation and leukemia-initiating capacity, and enhances quizartinib response."	0.8814
40185987	Cell biochemistry and biophysics	2025	CircARID1B Promotes MPP+-Induced Death and Inflammation in Dopaminergic Neurons by Elevating MAVS Through Sequestering miR-143-3p.	hsa_circ_0004381	circARID1B 	hsa_circ_ARID1B	ARID1B	Parkinson's disease 	MONDO:0005180	Parkinson disease	up-regulated	RT-qPCR	"This study found that circARID1B is up-regulated in MPP+-induced human dopaminergic SK-N-AS cell models of Parkinson's disease injury. circARID1B promotes neuronal apoptosis, LDH release, oxidative stress and inflammation by sponging miR-143-3p and increasing MAVS expression, while circARID1B knockdown has protective effects in vitro."	0.7615
40205799	Expert review of hematology	2025	Circ_0035381 contributes to the progression of acute myeloid leukemia via regulating miR-186-5p/CDCA3 pathway.	hsa_circ_0035381	Circ_0035381 	hsa_circ_PIGB	PIGB	acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; Microarray	Circ_0035381 is up-regulated in blood samples from AML patients and in AML cell lines. It promotes AML cell proliferation and glycolysis while suppressing apoptosis by acting as a miR-186-5p sponge and increasing CDCA3 expression. The study suggests circ_0035381 may serve as a potential AML biomarker and therapeutic target.	0.725
40215175	Cancer research	2025	Aberrant CircTMEM45A Facilitates Inflammatory Progression of Esophageal Squamous Cell Carcinoma through m5C-Mediated NLRP3 Activation.	hsa_circ_0066658	circTMEM45A 	hsa_circ_TMEM45A	TMEM45A	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circTMEM45A is an up-regulated oncogenic circRNA in ESCC that promotes malignant progression, including proliferation, migration, invasion, tumor growth and metastasis. Mechanistically, it functions as an epigenetic and protein-interaction hub, binding NSUN2/ALYREF/YBX1 to enhance m5C-mediated NLRP3 mRNA export and stability, binding U2AF2 to stabilize IL1B mRNA, and scaffolding IGF2BP2/HUR to stabilize IL1R1 mRNA, thereby activating NLRP3/caspase-1/IL1beta and IL1beta/IL1R1 inflammatory signaling. Clinically, high circTMEM45A expression correlates with advanced disease, poor survival, and potential diagnostic value in ESCC."	0.8999
40216011	Experimental cell research	2025	CircBRWD1 promotes hepatitis B virus replication and hepatocellular carcinoma progression by regulating the miR-513a-5p/TNPO1 axis.	hsa_circ_0061713	circBRWD1	hsa_circ_BRWD1	BRWD1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circBRWD1 is overexpressed in HBV-positive HCC tissues and cells and functions as an oncogenic circRNA. It promotes HBV replication, cccDNA accumulation, tumor cell proliferation, migration, invasion, and in vivo tumor growth while suppressing apoptosis. Mechanistically, circBRWD1 sponges miR-513a-5p to upregulate TNPO1, forming a circBRWD1/miR-513a-5p/TNPO1 regulatory axis."	0.869
40225990	American journal of translational research	2025	circRNA_0005927 inhibits gastric cancer metastasis by downregulating the miR-570-3p/FOXO3 axis.	hsa_circ_0005927		hsa_circ_VDAC3	VDAC3	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"circ_0005927 is downregulated in gastric cancer tissues and cell lines and is associated with diagnostic potential and prognosis. Functionally, circ_0005927 suppresses GC cell proliferation, colony formation, invasion and EMT by acting as a ceRNA for miR-570-3p to upregulate FOXO3."	0.7846
40227010	Journal of biochemical and molecular toxicology	2025	Circ_0038632 Acts as a Sponge of miR-4306 to Facilitate Breast Cancer Progression Through Regulating CXCR4 Expression.	hsa_circ_0038632		hsa_circ_PLK1	PLK1	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0038632 is up-regulated in breast cancer tissues and cell lines and appears to act as an oncogenic circRNA. It promotes breast cancer cell proliferation, migration, invasion, metastasis, angiogenesis and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ_0038632 sponges miR-4306 to increase CXCR4 expression, forming a circ_0038632/miR-4306/CXCR4 regulatory axis."	0.7375
40233171	Genetic testing and molecular biomarkers	2025	"Comprehensive Expression Profiles of mRNAs, LncRNAs, and CircRNAs in the Colon Specimens of Patients with Slow Transit Constipation."	hsa_circ_0000994				Slow transit constipation 	MONDO:0002203	constipation disorder	up-regulated	RNA-seq	"hsa_circ_0000994 was identified as an upregulated circRNA enriched in the upregulated ceRNA network in colon tissues from STC patients. The study suggests that it may contribute to STC development through a predicted circRNA-miRNA-mRNA regulatory network associated with mRNA splicing/protein stability processes and MAPK signaling, but no RT-qPCR validation or named miRNA/mRNA partners were reported for this circRNA."	0.348
40233171	Genetic testing and molecular biomarkers	2025	"Comprehensive Expression Profiles of mRNAs, LncRNAs, and CircRNAs in the Colon Specimens of Patients with Slow Transit Constipation."	hsa_circ_0008699				Slow transit constipation 	MONDO:0002203	constipation disorder	down-regulated	RNA-seq	"hsa_circ_0008699 was identified as a downregulated circRNA enriched in the downregulated ceRNA/coexpression network in colon tissues from STC patients. The study suggests that it may participate in STC through predicted circRNA-miRNA-mRNA interactions linked to extracellular matrix organization, JUN kinase activity, axon guidance, ECM-receptor interaction, and TGF-beta signaling, but no RT-qPCR validation or named miRNA/mRNA partners were reported for this circRNA."	0.348
40237951	Molecular neurobiology	2025	CircGTF2H2C Regulates NLRP3 Dephosphorylation via Modulating PTPN11 Expression in Spinal Cord Injury.		CircGTF2H2C 	rno_circ_GTF2H2C	GTF2H2C	spinal cord injury 	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR	"circGTF2H2C is up-regulated in rat SCI tissues and SCI cell models. It promotes inflammatory cytokine release and SCI-associated pathological changes by sponging miR-1323 to increase PTPN11 expression, leading to NLRP3 dephosphorylation and NLRP3-mediated inflammatory regulation. Knockdown of circGTF2H2C improves functional recovery in SCI rats, suggesting therapeutic potential."	0.8152
40239729	Bone	2025	Rhizoma Drynariae-derived EV-like particles alleviate osteoporosis by promoting osteogenic differentiation in BMSCs through the activation of the hsa_circ_0001275/miR-422a pathway.	hsa_circ_0001275				osteoporosis 	MONDO:0005298	osteoporosis	up-regulated	RT-qPCR; ISH; Microarray	"hsa_circ_0001275 is upregulated during osteogenic differentiation and promotes osteogenic differentiation/mineralized nodule formation in h-BMSCs. It acts as a ceRNA by sponging miR-422a, thereby relieving repression of IGF1R and contributing to the anti-osteoporotic effect of RD-EVLP."	0.7845
40239828	Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association	2025	Circ_0000215 aggravates cerebral ischemic vertigo by targeting miR-361-3p to promote neuroinflammation and apoptosis.	hsa_circ_0000215	circ_0000215 	hsa_circ_CAMK1D	CAMK1D	cerebral ischemic vertigo 	MONDO:0002679	cerebral infarction	up-regulated	RT-qPCR	"circ_0000215 is up-regulated in serum from cerebral ischemia patients, especially those who develop vertigo, and it shows diagnostic and predictive value for CI-related vertigo. Functionally, circ_0000215 aggravates cerebral ischemic vertigo by sponging miR-361-3p, promoting neuroinflammation and apoptosis; its knockdown improves neurological dysfunction and reduces OGD/R-induced neuronal injury."	0.7967
40239828	Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association	2025	Circ_0000215 aggravates cerebral ischemic vertigo by targeting miR-361-3p to promote neuroinflammation and apoptosis.	mmu_circ_0000215	circ_0000215 	mmu_circ_Camk1d	CAMK1D	cerebral ischemic vertigo 	MONDO:0002679	cerebral infarction	up-regulated	RT-qPCR	"circ_0000215 is up-regulated in serum from cerebral ischemia patients, especially those who develop vertigo, and it shows diagnostic and predictive value for CI-related vertigo. Functionally, circ_0000215 aggravates cerebral ischemic vertigo by sponging miR-361-3p, promoting neuroinflammation and apoptosis; its knockdown improves neurological dysfunction and reduces OGD/R-induced neuronal injury."	0.7967
40242872	Circulation research	2025	Novel Truncated Peptide Derived From circCDYL Exacerbates Cardiac Hypertrophy.		circCDYL	rno_circ_cdyl	cdyl	pathological cardiac hypertrophy 	MONDO:0005267	heart disorder	up-regulated	RT-qPCR; RNA-seq	"circCDYL is an Ang II-induced, conserved cardiac circRNA derived from cdyl/CDYL that promotes cardiomyocyte hypertrophy and worsens pathological cardiac hypertrophy. It functions by m6A-dependent translation of tCDYL-100, which antagonizes CDYL-mediated REST-EHMT2 transcriptional repression and activates prohypertrophic genes such as rhoa and nppb. Silencing circCDYL in mouse hearts attenuates Ang II-induced hypertrophy, suggesting a potential therapeutic target."	0.8165
40242872	Circulation research	2025	Novel Truncated Peptide Derived From circCDYL Exacerbates Cardiac Hypertrophy.		circCDYL	mmu_circ_cdyl 	cdyl	pathological cardiac hypertrophy 	MONDO:0005267	heart disorder	up-regulated	RT-qPCR; RNA-seq	"circCDYL is an Ang II-induced, conserved cardiac circRNA derived from cdyl/CDYL that promotes cardiomyocyte hypertrophy and worsens pathological cardiac hypertrophy. It functions by m6A-dependent translation of tCDYL-100, which antagonizes CDYL-mediated REST-EHMT2 transcriptional repression and activates prohypertrophic genes such as rhoa and nppb. Silencing circCDYL in mouse hearts attenuates Ang II-induced hypertrophy, suggesting a potential therapeutic target."	0.8165
40242872	Circulation research	2025	Novel Truncated Peptide Derived From circCDYL Exacerbates Cardiac Hypertrophy.		circCDYL	hsa_circ_CDYL	CDYL	pathological cardiac hypertrophy 	MONDO:0005267	heart disorder	up-regulated	RT-qPCR; RNA-seq	"circCDYL is an Ang II-induced, conserved cardiac circRNA derived from cdyl/CDYL that promotes cardiomyocyte hypertrophy and worsens pathological cardiac hypertrophy. It functions by m6A-dependent translation of tCDYL-100, which antagonizes CDYL-mediated REST-EHMT2 transcriptional repression and activates prohypertrophic genes such as rhoa and nppb. Silencing circCDYL in mouse hearts attenuates Ang II-induced hypertrophy, suggesting a potential therapeutic target."	0.8165
40246114	International journal of biological macromolecules	2025	Chronic hypoxia-induced upregulation of hsa_circ_0005255 attenuates myocardial injury via targeting hsa-miR-3916/FTO/m6A axis.	hsa_circ_0005255				cyanotic congenital heart disease 	MONDO:0005453	congenital heart disease	up-regulated	RT-qPCR; RNA-seq; Microarray	"hsa_circ_0005255 is upregulated in myocardial samples from patients with cyanotic heart disease and in chronic hypoxia models. It protects cardiomyocytes by sponging hsa-miR-3916 to regulate FTO-dependent m6A modification, reducing apoptosis and myocardial injury, while its inhibition worsens ischemia/reperfusion injury in vivo. Clinically, its expression is negatively correlated with myocardial enzyme levels and early clinical outcome measures."	0.8491
40250442	Cancer cell	2025	A circular RNA in neuroendocrine carcinomas.		circRMST	hsa_circ_RMST	RMST	small cell lung cancer 	MONDO:0008433	small cell lung carcinoma	up-regulated	RNA-seq	"circRMST is highly upregulated in NEPC and ASCL1-subtype SCLC and promotes the ASCL1-positive neuroendocrine phenotype. Mechanistically, it binds SOX2 and NKX2-1, supports SOX2 target-gene binding, stabilizes NKX2-1, and thereby promotes ASCL1 expression, proliferation, tumor growth, and neuroendocrine tumor formation."	0.6823
40250442	Cancer cell	2025	A circular RNA in neuroendocrine carcinomas.		circRMST	mmu_circ_RMST	RMST	small cell lung cancer 	MONDO:0008433	small cell lung carcinoma	up-regulated	RNA-seq	"circRMST is highly upregulated in NEPC and ASCL1-subtype SCLC and promotes the ASCL1-positive neuroendocrine phenotype. Mechanistically, it binds SOX2 and NKX2-1, supports SOX2 target-gene binding, stabilizes NKX2-1, and thereby promotes ASCL1 expression, proliferation, tumor growth, and neuroendocrine tumor formation."	0.6823
40250664	International journal of biological macromolecules	2025	Circular RNA CDYL facilitates hepatocellular carcinoma stemness and PD-L1+ exosomes-mediated immunotherapy resistance via stabilizing hornerin protein by blocking synoviolin 1-mediated ubiquitination.		Circ-CDYL 	hsa_circ_CDYL		hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH	"Circ-CDYL is an oncogenic circRNA studied in HCC that promotes stemness and resistance to anti-PD-L1 immunotherapy. It binds HRNR, blocks SYVN1-mediated HRNR ubiquitination, stabilizes HRNR protein, activates mTORC1-p70S6K signaling, and increases PD-L1 expression and PD-L1+ exosome production, thereby suppressing CD8+ T cell activity and immune killing."	0.8109
40250678	International journal of biological macromolecules	2025	RBM24-mediated biogenesis of circ23679 protects cardiomyocytes against apoptosis via sponging miR-15b-5p.		novel_circ_0023679 	mmu_circ_Lrrfip2	Lrrfip2	dilated cardiomyopathy 	MONDO:0005021	dilated cardiomyopathy	down-regulated	RT-qPCR; RNA-seq	"This study identifies mouse circ23679, derived from Lrrfip2, as an RBM24-dependent circRNA that is down-regulated in Rbm24 knockout hearts. RBM24 promotes circ23679 biogenesis through phosphorylation-dependent exon inclusion, while circ23679 protects cardiomyocytes by sponging miR-15b-5p and suppressing apoptosis. In mouse heart failure and myocardial infarction models, circ23679 overexpression reduces apoptosis, infarct size, and fibrosis and improves cardiac function."	0.762
40250696	Cellular signalling	2025	Circ847 upregulation via CAFs suppresses salivary adenoid cystic carcinoma progression through VIM-EMT.	hsa_circ_0000847 		hsa_circ_SMAD2	SMAD2	salivary adenoid cystic carcinoma 	MONDO:0003175	salivary gland adenoid cystic carcinoma	down-regulated	RT-qPCR; ISH; RNA-seq	"Circ847 is a CAF-suppressed circRNA in SACC whose restoration inhibits SACC proliferation, migration, invasion, neural invasion and lung metastasis. Mechanistically, circ847 binds VIM and reduces VIM protein stability, thereby suppressing EMT-related signaling. Clinically, low circ847 expression is associated with metastatic and advanced SACC features, and NP-mediated circ847 plasmid delivery is presented as a potential therapeutic strategy."	0.8621
40250752	Life sciences	2025	N6-methyladenosine-modified circQKI inhibits prostate cancer docetaxel-sensitivity via miR-188-3p/Beclin-1 pathway.	hsa_circ_0005328	circQKI 	hsa_circ_QKI	QKI	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circQKI is upregulated in docetaxel-resistant prostate cancer cells and reduces docetaxel sensitivity. METTL3-mediated m6A modification stabilizes circQKI through IGF2BP2, and accumulated circQKI sponges miR-188-3p to increase Beclin-1 expression, activate autophagy, inhibit apoptosis, and promote chemoresistance."	0.86
40251360	Cell biochemistry and biophysics	2025	Identification of circRNA-Based Biomarkers and ceRNA Mechanism in Non-Small Cell Lung Cancer.	hsa_circ_0049271				non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0049271 was significantly downregulated in NSCLC tumor tissues and was identified as one of five potential diagnostic circRNA biomarkers. Its proposed mechanism is based on a bioinformatically constructed circRNA-miRNA-mRNA ceRNA network, but no individual mechanistic experiment was performed for this circRNA."	0.459
40251360	Cell biochemistry and biophysics	2025	Identification of circRNA-Based Biomarkers and ceRNA Mechanism in Non-Small Cell Lung Cancer.	hsa_circ_0029426				non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0029426 was significantly downregulated in NSCLC tumor tissues and was identified as one of five potential diagnostic circRNA biomarkers. The study placed it in a predicted ceRNA framework, but did not experimentally validate its specific regulatory targets."	0.459
40251360	Cell biochemistry and biophysics	2025	Identification of circRNA-Based Biomarkers and ceRNA Mechanism in Non-Small Cell Lung Cancer.	hsa_circ_0084443				non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0084443 was upregulated in NSCLC tumor tissues and NSCLC cell lines. Knockdown experiments in A549 cells showed that it promotes malignant cell behaviors, including growth, migration, invasion, and colony formation, while suppressing apoptosis; it was also incorporated into a predicted ceRNA network and proposed as a potential drug target."	0.6458
40251360	Cell biochemistry and biophysics	2025	Identification of circRNA-Based Biomarkers and ceRNA Mechanism in Non-Small Cell Lung Cancer.	hsa_circ_0015278				non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0015278 was significantly downregulated in NSCLC tumor tissues and was identified as one of five potential diagnostic circRNA biomarkers. The paper linked the five biomarkers to predicted ceRNA regulation and tumor-related pathways, but did not experimentally validate a specific mechanism for this circRNA."	0.459
40251360	Cell biochemistry and biophysics	2025	Identification of circRNA-Based Biomarkers and ceRNA Mechanism in Non-Small Cell Lung Cancer.	hsa_circ_0024731				non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0024731 was significantly upregulated in NSCLC tumor tissues and was identified as one of five potential diagnostic circRNA biomarkers. The study suggested its involvement in a predicted ceRNA network and tumor-related biological processes, but no individual functional or mechanistic experiment was reported for this circRNA."	0.459
40252715	Experimental gerontology	2025	Novel_circ_0004013 targeting miR-29a-3p affects age-related hearing loss in miR-29a mouse model by RNA-seq analysis.		novel_circ_0004013 			age-related hearing loss 	MONDO:0043765	presbycusis	up-regulated	RT-qPCR; ISH; RNA-seq	"novel_circ_0004013 is up-regulated in t-BHP-treated HEI-OC1 cells and in the cochlea of miR-29a-deficient mice, especially in hair cells and stria vascularis regions. It is mainly cytoplasmic and functions as a sponge for miR-29a-3p, promoting oxidative stress and apoptosis in the ARHL-related cellular model."	0.7296
40261967	The Plant cell	2025	The circular RNA circANK suppresses rice resistance to bacterial blight by inhibiting microRNA398b-mediated defense.		circANK 	osa_circ_OsANK		bacterial blight 	Plant diseases		down-regulated	RT-qPCR	"Os-circANK is a rice circRNA derived from the OsANK/ankyrin repeat-containing protein gene and is down-regulated after Xoo infection. It suppresses bacterial blight resistance by sponging miR398b, thereby relieving miR398b-mediated repression of CSD1, CSD2, SODX, and CCSD, lowering ROS/H2O2-associated defense responses. Knockdown of Os-circANK enhances rice resistance, while overexpression increases susceptibility."	0.759
40262487	Tissue & cell	2025	CircRNA hsa_ circ_0009022 inhibits colorectal cancer progression by sponging miR-576-5p and complexing with FMRP.	hsa_circ_0009022	hsa_ circ_0009022 	hsa_circ_PPP4R1	PPP4R1	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0009022/circ_0009022 is down-regulated in CRC tissues and cell lines and acts as a tumor-suppressive circRNA. It inhibits proliferation, migration, metastasis and EMT by sponging miR-576-5p to regulate TFAP2A and by binding FMRP to reduce Vimentin-related EMT activity. The study suggests circ_0009022 may be a potential biomarker and therapeutic target for CRC."	0.8388
40268132	Cancer letters	2025	Isoliquiritigenin reduces brain metastasis by circNAV3-ST6GALNAC5-EGFR axis in triple-negative breast cancer.	hsa_circ_0008509	circNAV3	hsa_circ_NAV3	NAV3	triple-negative breast cancer brain metastasis 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; RNA-seq	"circNAV3 is a NAV3-derived human circRNA that is upregulated in TNBC tissues and TNBC brain metastases and is associated with poorer brain metastasis-free survival. It promotes TNBC proliferation, migration, invasion, EMT, angiogenesis, BBB transmigration, tumor growth, and brain metastasis. Mechanistically, circNAV3 sponges miR-4262 to upregulate ST6GALNAC5, enhancing EGFR sialylation/activation and PI3K/Akt signaling; ISL suppresses TNBC brain metastasis by downregulating this circNAV3-centered axis."	0.8996
40278968	Journal of molecular histology	2025	N6-methyladenosine-modified circ_0000517 promotes non-small cell lung cancer metastasis via miR-1233-3p/CDH6 axis.	hsa_circ_0000517	circ_0000517 	hsa_circ_RPPH1	RPPH1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0000517 is up-regulated in NSCLC tissues and cell lines and acts as an oncogenic circRNA. METTL14-mediated m6A modification stabilizes circ_0000517, while cytoplasmic circ_0000517 sponges miR-1233-3p to increase CDH6 expression, promoting proliferation, migration, invasion, tumor growth and EMT. The study suggests circ_0000517 as a potential therapeutic target in NSCLC."	0.807
40279987	Molecular immunology	2025	Acid-sensing ion channel 1a promotes LPS-induced acute lung injury through the circRNA 18-658/miR-127-5p/TRIM72 axis.		circRNA 18-658 		ENSRNOG00000011853	acute lung injury 	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR; RNA-seq	"This study identifies rat circRNA18-658 as an up-regulated circRNA in LPS-induced acute lung injury. Mechanistically, circRNA18-658 is implicated in a ceRNA axis involving miR-127-5p and TRIM72, and silencing circRNA18-658 reduces LPS-induced apoptosis-related molecular changes in RLE-6TN lung epithelial cells."	0.4852
40288351	Current problems in cancer	2025	hsa_circ_0008285: Circular RNA with potential as a biomarker in ovarian cancer.	hsa_circ_0008285		hsa_circ_CHD1L	chromodomain Y-like gene	ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; RNA-seq	"This study identified hsa_circ_0008285 as an upregulated circRNA in ovarian cancer tissues and plasma. It showed diagnostic potential, with ROC analysis indicating moderate performance and improved sensitivity/specificity when combined with CA_125. The study also linked higher expression to tumor size, differentiation, and T stage."	0.4679
40293839	American journal of physiology. Cell physiology	2025	Epigenetic modulation of cisplatin sensitivity by the M6A-linked ceRNA network in non-small cell lung cancer.	hsa_circ_0003028	circFUT8	hsa_circ_FUT8	FUT8	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circFUT8 is upregulated in NSCLC and promotes malignant phenotypes and cisplatin resistance. Mechanistically, it sponges miR-185-5p to upregulate the M6A reader HNRNPC, thereby promoting proliferation, migration, invasion, tumor growth and lung metastasis while suppressing apoptosis and cisplatin sensitivity."	0.7634
40293839	American journal of physiology. Cell physiology	2025	Epigenetic modulation of cisplatin sensitivity by the M6A-linked ceRNA network in non-small cell lung cancer.	hsa_circ_0001998		hsa_circ_FUT8	FUT8	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	Microarray	hsa_circ_0001998 was identified by bioinformatics analysis as an upregulated FUT8-linked circRNA in NSCLC datasets and as a predicted upstream regulator of miR-185-5p in the HNRNPC-centered ceRNA network. The paper does not report separate RT-qPCR or functional validation specifically for hsa_circ_0001998.	0.1768
40293855	Journal of biochemical and molecular toxicology	2025	Knockdown of circRNA_0030042 Attenuates Heart Failure via miR-568/PRG4 Pathway.	hsa_circ_0030042	circRNA_0030042 	hsa_circ_FOXO1	FOXO1	heart failure	MONDO:0005252	heart failure	up-regulated	RT-qPCR	"Human hsa_circ_0030042 is up-regulated in peripheral blood from heart failure patients and in H2O2-induced AC16 cardiomyocytes. Its knockdown protects the in vitro heart failure model by improving viability/proliferation and suppressing apoptosis and ferroptosis through the miR-568/PRG4 regulatory axis, and it may have diagnostic value for heart failure."	0.8429
40293855	Journal of biochemical and molecular toxicology	2025	Knockdown of circRNA_0030042 Attenuates Heart Failure via miR-568/PRG4 Pathway.		circRNA_0030042 	mmu_circ_FOXO1	FOXO1	heart failure	MONDO:0005252	heart failure	up-regulated	RT-qPCR	"Mouse mmu-circRNA_0030042 is up-regulated in heart tissues of TAC-induced heart failure mice. Knockdown of mmu-circRNA_0030042 improves cardiac dysfunction and reduces myocardial injury, histopathological damage, fibrosis, apoptosis, and ferroptosis, likely through the miR-568/PRG4 pathway."	0.4236
40305817	Georgian medical news	2025	WHOLE TRANSCRIPTOME SEQUENCING AND CIRC_HSA_0001847 ON PROLIFERATION AND INVASION OF ORAL SQUAMOUS CELL CARCINOMA.	hsa_circ_0001847	circ-UBAP2 	hsa_circ_UBAP2	UBAP2	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001847 is up-regulated in OSCC tissues and cell lines. Functional knockdown experiments indicate that it promotes OSCC proliferation, migration, invasion and EMT. Mechanistically, the study supports a ceRNA-like hsa_circ_0001847/miR-3188/onecut2 axis, suggesting potential diagnostic and therapeutic value in OSCC."	0.6815
40306111	International immunopharmacology	2025	Hsa_circ_0008085 acts as a miR-146a-5p sponge to suppress influenza a virus replication via modulating of TRAF6.	hsa_circ_0008085	circ_0008085 	hsa_circ_STAT2	STAT2	Influenza A virus infection 	MONDO:0005812	influenza	up-regulated	RT-qPCR	"hsa_circ_0008085 is an IAV-induced human circRNA derived from STAT2 and is up-regulated through JAK/STAT activation in infected A549 cells. It suppresses IAV replication by sponging miR-146a-5p, increasing TRAF6 expression, and enhancing antiviral signaling including NF-kappaB activation. The study suggests hsa_circ_0008085 as a potential antiviral therapeutic target."	0.6868
40315630	International immunopharmacology	2025	Epigenetic mechanism of iPSC-MSC-EVs in colonic epithelial cell pyroptosis in ulcerative colitis cell models via modulation of ELF3/miR-342-3p/KDM6B axis and histone methylation.		circ-CCND1 	hsa_circ_CCND1	CCND1	ulcerative colitis 	MONDO:0005101	ulcerative colitis	down-regulated	RT-qPCR	"In this in vitro UC model, circ-CCND1 expression decreased after DSS treatment and was delivered into colonic epithelial cells by iPSC-MSC-derived extracellular vesicles. EV-carried circ-CCND1 binds KDM6B and modulates the KDM6B/ELF3/miR-342-3p feedback axis and H3K27me3-related histone methylation, thereby suppressing inflammatory pyroptosis."	0.6649
40316188	International journal of pharmaceutics	2025	Targeted delivery of circPDHK1 siRNA via aptamer functionalized lipid nanoparticles inhibits ccRCC growth and migration.		circPDHK1 	hsa_circ_PDHK1	PDHK1	Clear Cell Renal Cell Carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR	"circPDHK1 is an upregulated oncogenic circRNA in ccRCC that encodes PDHK1-241aa and promotes tumor proliferation, migration, and metastatic dissemination through activation of the AKT-mTOR signaling axis. This study developed AS1411/LNP-si circPDHK1 to deliver siRNA targeting circPDHK1, which reduced circPDHK1 and PDHK1-241aa levels, inhibited mTOR/AKT phosphorylation, suppressed ccRCC growth and migration, promoted apoptosis, and reduced tumor growth and hepatic metastasis in vivo."	0.6221
40318815	Gene	2025	CircPAPPA binds to PAPPA and promotes trophoblast proliferation in spontaneous abortion through the formation of circPAPPA-PAPPA complexes.	hsa_circ_0003076	circPAPPA-814nt 	hsa_circ_PAPPA	PAPPA	spontaneous abortion 	MONDO:0006774	habitual spontaneous abortion	down-regulated	RT-qPCR; RNA-seq	"circPAPPA (hsa_circ_0003076), derived from the PAPPA gene, is down-regulated in villus tissues from spontaneous abortion. It promotes trophoblast/JAR cell proliferation in vitro by interacting with PAPPA protein and forming a circPAPPA-PAPPA circRNA-protein complex, suggesting potential therapeutic relevance in spontaneous abortion."	0.8311
40320200	Experimental cell research	2025	Hsa_circ_0000479 promotes gastric cancer progression by inhibiting BTRC-mediated ubiquitination of G3BP1.	hsa_circ_0000479	cyclic RNA EPSTI1 	hsa_circ_EPSTI1	EPSTI1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000479/circEPSTI1 is an upregulated cytoplasmic circRNA in gastric cancer that promotes malignant progression, including proliferation, migration, EMT, tumor growth and metastasis. Mechanistically, it interacts with G3BP1 and blocks BTRC-mediated ubiquitination-dependent degradation of G3BP1, supporting the hsa_circ_0000479-G3BP1-BTRC axis as a potential therapeutic target."	0.8661
40320861	Journal of biochemical and molecular toxicology	2025	Circ_0003520/miR-205-5p/CUL4B Axis Drives the Progression of Clear Cell Renal Carcinoma.	hsa_circ_0003520	circ_0003520 	hsa_circ_NETO2	NETO2	Clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR	"Circ_0003520 is up-regulated in ccRCC tissues and cells and acts as an oncogenic circRNA. It promotes proliferation, migration, invasion, angiogenesis and in vivo tumor growth while suppressing apoptosis, at least partly through the circ_0003520/miR-205-5p/CUL4B ceRNA axis."	0.8443
40326973	General physiology and biophysics	2025	Hsa_circ_0007905 as a modulator of miR-330-5p and VDAC1: Enhancing stemness and reducing apoptosis in cervical cancer stem cells.	hsa_circ_0007905	circSTX6	hsa_circ_STX6	STX6	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0007905 is up-regulated in cervical cancer tissues and cervical cancer stem cell-enriched subsets. It promotes CSC proliferation, migration, invasion and self-renewal while suppressing apoptosis by sponging miR-330-5p and thereby regulating VDAC1 expression. High expression is associated with lymph node metastasis and FIGO stage, suggesting potential therapeutic relevance."	0.8206
40329757	Analytical chemistry	2025	Construction of a Ligation-Controlled Single-Molecule Biosensor for Simultaneous Measurement of Multiple Cancer-Related circRNAs in Clinical Tissues.		circFOXO3	hsa_circ_FOXO3		breast cancer	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	This study used a ligation-controlled single-molecule biosensor and qRT-PCR to measure circFOXO3 in human cells and breast tissues. circFOXO3 was downregulated in breast cancer tissues compared with healthy tissues and was evaluated as a diagnostic marker with ROC analysis.	0.4187
40329757	Analytical chemistry	2025	Construction of a Ligation-Controlled Single-Molecule Biosensor for Simultaneous Measurement of Multiple Cancer-Related circRNAs in Clinical Tissues.		circMTO1	hsa_circ_MTO1		breast cancer	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	This study used a ligation-controlled single-molecule biosensor and qRT-PCR to measure circMTO1 in human cells and breast tissues. circMTO1 showed lower levels in breast cancer tissues than in healthy tissues and was evaluated as a diagnostic marker with ROC analysis.	0.4187
40330565	Reports of biochemistry & molecular biology	2024	Platelet-Derived circRNAs hsa_circ_0004771 and hsa_circ_0019120 Differentially Expressed in Colorectal Cancer and Polyps.	hsa_circ_0004771	hsa_circNRIP1_007	hsa_circ_NRIP1	NRIP1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"Platelet-derived hsa_circ_0004771 was upregulated in CRC and advanced polyp patients, with statistically significant upregulation in CRC compared with healthy controls. The study supports its potential clinical utility as a non-invasive biomarker for CRC risk assessment and early detection, especially when combined with hsa_circ_0019120."	0.4187
40330565	Reports of biochemistry & molecular biology	2024	Platelet-Derived circRNAs hsa_circ_0004771 and hsa_circ_0019120 Differentially Expressed in Colorectal Cancer and Polyps.	hsa_circ_0019120	hsa_circBTAF1_002	hsa_circ_BTAF1	BTAF1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"Platelet-derived hsa_circ_0019120 was significantly upregulated in both advanced polyp patients and CRC patients compared with healthy controls. The study supports its potential as a non-invasive biomarker for CRC and advanced polyp risk assessment and early detection, including combined diagnostic use with hsa_circ_0004771."	0.4187
40336343	Cardiovascular research	2025	Atrial remodelling and atrial fibrillation self-sustaining: the role of circulating circDGCR8.	hsa_circ_0001204	circDGCR8	hsa_circ_DGCR8	DGCR8	atrial fibrillation 	MONDO:0004981	atrial fibrillation	up-regulated	RT-qPCR; ISH; Microarray	"This study identifies circulating hsa_circ_0001204/circDGCR8 as an up-regulated plasma circRNA in persistent AF compared with paroxysmal AF. circDGCR8 promotes atrial fibroblast proliferation, collagen synthesis, and fibroblast-to-myofibroblast transition, with downstream involvement of IL-17 and TNF signalling and inverse association with DGCR8. Clinically, higher circDGCR8 levels correlate with left atrial low voltage zone percentage and predict AF progression and recurrence after radiofrequency catheter ablation."	0.8333
40344697	Biosensors & bioelectronics	2025	Engineering of a palindrome-crosslinked DNA nanoaggregate for rapid detection of circular RNA and precise identification of lung cancer.	hsa_circ_0008928	circSATB2	hsa_circ_SATB2	SATB2	lung cancer 	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"This study uses a palindrome-crosslinked DNA nanoaggregate fluorescence system and qRT-PCR to detect circSATB2 in lung cancer cells and clinical lung cancer tissues. circSATB2 is up-regulated in lung cancer, negatively regulates miR-326, and is associated with NSCLC progression-related proliferation, migration, and invasion. Clinically, circSATB2 shows diagnostic value for distinguishing healthy donors from lung cancer patients and for classifying disease stages and subtypes."	0.5127
40345505	Gene	2025	Nsclc-derived exosomal hsa_circ_0003026 promotes tumor growth through macrophage M2 polarization via hsa-miR-1183/XRN2 axis.	hsa_circ_0003026	hsa_circUSP10_006 	hsa_circ_USP10	USP10	Non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"This study shows that exosomal hsa_circ_0003026 is up-regulated in NSCLC patient serum and NSCLC cell line-derived exosomes. It promotes NSCLC growth by inducing macrophage M2 polarization through a hsa-miR-1183/XRN2 ceRNA-like regulatory axis, and it may serve as a serum exosomal biomarker or therapeutic target."	0.7751
40345993	Journal of biochemical and molecular toxicology	2025	Circ_0001715 Mediated Progression and Inflammation in Fibroblast-Like Synoviocytes of Rheumatoid Arthritis by Targeting miR-326/TLR-4-NF-kappaB Pathway.	hsa_circ_0001715	circ_0001715 	hsa_circ_LIMK1	LIMK1	Rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; Microarray	"Circ_0001715 is up-regulated in RA patient synovial tissues, TNF-alpha-induced HFLS-RA cells, and CIA mouse synovial tissues. Functionally, circ_0001715 promotes proliferation and inflammation and inhibits apoptosis in RA-FLSs. Mechanistically, it sequesters miR-326 to regulate the TLR-4/NF-kappaB axis, suggesting potential diagnostic and therapeutic value in RA."	0.6835
40347926	Phytomedicine : international journal of phytotherapy and phytopharmacology	2025	The anti-metastatic effect of elemene in human hepatocellular carcinoma is potentially mediated by inhibiting a novel driver-circBPTF.	hsa_circ_0045431	circBPTF	hsa_circ_BPTF	BPTF	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circBPTF is an up-regulated human circRNA in HCC that promotes migration, invasion, and lung metastasis. It acts as a miR-548m sponge to increase POLR3G and ZBTB41 expression, while its biogenesis is regulated by HNRNPC and HNRNPU. Elemene inhibits HCC metastasis at least partly by downregulating HNRNPC, suppressing circBPTF, and reducing the circBPTF/miR-548m/POLR3G network."	0.8834
40347926	Phytomedicine : international journal of phytotherapy and phytopharmacology	2025	The anti-metastatic effect of elemene in human hepatocellular carcinoma is potentially mediated by inhibiting a novel driver-circBPTF.	hsa_circ_0003060	circSUCLG2	hsa_circ_SUCLG2	SUCLG2	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RNA-seq	circSUCLG2 was identified by circRNA sequencing as a candidate circRNA that is elevated in HCC patient samples and suppressed by elemene treatment in HCC cells. The study did not functionally validate its mechanism or biological role.	0.3991
40347926	Phytomedicine : international journal of phytotherapy and phytopharmacology	2025	The anti-metastatic effect of elemene in human hepatocellular carcinoma is potentially mediated by inhibiting a novel driver-circBPTF.	hsa_circ_0046200	circNPLOC4	hsa_circ_NPLOC4	NPLOC4	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RNA-seq	circNPLOC4 was identified by circRNA sequencing as a candidate circRNA elevated in HCC patient samples and suppressed by elemene treatment in HCC cells. The study did not experimentally characterize its mechanism or biological function.	0.3991
40347926	Phytomedicine : international journal of phytotherapy and phytopharmacology	2025	The anti-metastatic effect of elemene in human hepatocellular carcinoma is potentially mediated by inhibiting a novel driver-circBPTF.	hsa_circ_0046386	circCCDC57	hsa_circ_CCDC57	CCDC57	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RNA-seq	circCCDC57 was identified by circRNA sequencing as a candidate circRNA elevated in HCC patient samples and suppressed by elemene treatment in HCC cells. Its mechanism and biological function were not experimentally validated in this study.	0.3991
40349468	Ecotoxicology and environmental safety	2025	Arsenic-induced circASXL1 regulates 16HBE cell proliferation through the P65 signaling axis.	hsa_circ_0001136	circASXL1 	hsa_circ_ASXL1	ASXL1	arsenic-induced pulmonary pathologies 	MONDO:0021178	injury	up-regulated	RT-qPCR	"In 16HBE human bronchial epithelial cells, sodium arsenite increased circASXL1 expression. Functional knockdown experiments showed that reduced circASXL1 promotes cell viability and proliferation, associated with STAT3 activation, increased P65 transcription, NF-kappaB pathway activation, and altered P65 ubiquitination. ILF3 knockdown reduced circASXL1 expression, suggesting ILF3 may regulate circASXL1 biogenesis in this arsenic-induced lung toxicity model."	0.5554
40350652	Journal of physiology and pharmacology : an official journal of the Polish Physiological Society	2025	circ-C20orf11 promotes karyopherin alpha 2 expression through miR-495-3p and affects non-small cell lung cancer development.	hsa_circ_0061140	circ-C20orf11 	hsa_circ_C20orf11	C20orf11	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ-C20orf11 is up-regulated in NSCLC tissues and cell lines and is associated with TNM stage, lymph node metastasis, and poor prognosis. Functionally, it promotes NSCLC cell proliferation, migration and invasion while inhibiting apoptosis. Mechanistically, circ-C20orf11 sponges miR-495-3p to increase KPNA2 expression, forming a circ-C20orf11/miR-495-3p/KPNA2 axis that accelerates NSCLC progression."	0.7412
40357770	Current pharmaceutical biotechnology	2025	Circ-LRP6 Inhibits the Development and Progression of AAA Via miR-29a-3p/HIF-1alpha Axis.	hsa_circ_0000378	circLRP6 	hsa_circ_LRP6	LRP6	abdominal aortic aneurysm 	MONDO:0005350	abdominal aortic aneurysm	down-regulated	RT-qPCR; ISH; Microarray	"circLRP6 is down-regulated in AAA tissues, Ang II-induced hAoSMCs, and mouse AAA aorta samples. Its overexpression suppresses Ang II-induced hAoSMC viability and proliferation, modulates cell cycle changes, and promotes apoptosis. Mechanistically, circLRP6 functions through a miR-29a-3p/HIF-1alpha-related axis and may serve as a potential therapeutic target for AAA."	0.78
40360086	Life sciences	2025	Nuclear circGUSBP1 promotes cancer stemness via transcriptional coordination with OCT4.		circGUSBP1 	hsa_circ_GUSBP1	GUSBP1	Endometrial cancer 	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR; RNA-seq	"circGUSBP1 is a human GUSBP1-derived nuclear circRNA that is upregulated in endometrial cancer stem-like tumorspheres. It promotes tumorsphere formation, migration and cisplatin resistance, likely by acting as a nuclear transcriptional co-activator that coordinates with OCT4 to regulate stemness-related genes and chromatin remodelers. Higher GUSBP1 expression used as a surrogate for circGUSBP1 is associated with poor survival outcomes in TCGA endometrial cancer patients."	0.7785
40366539	Applied biochemistry and biotechnology	2025	The Role of Hsa_circ_0087862/miR-149-5p/TRAF6 Regulatory Axis in Colorectal Cancer Progression.	hsa_circ_0087862	circ-RAD23B	hsa_circ_RAD23B	RAD23B	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"Hsa_circ_0087862 is up-regulated in colorectal cancer tissues and cell lines and acts as an oncogenic circRNA. Its silencing suppresses CRC cell proliferation and invasion while promoting apoptosis, mainly through sponging miR-149-5p and relieving regulation of TRAF6. The study suggests the hsa_circ_0087862/miR-149-5p/TRAF6 axis as a potential anti-CRC therapeutic target."	0.7435
40371159	American journal of cancer research	2025	Circ_0000190 inhibits the progression of triple negative breast cancer by regulating miR-301a/MEOX2 pathway.	hsa_circ_0000190	Circ_0000190			triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	down-regulated	RT-qPCR	"circ_0000190 is downregulated in TNBC cell lines and functions as a tumor-suppressive circRNA. It inhibits proliferation, migration, invasion, EMT and xenograft tumor growth while promoting apoptosis through a ceRNA mechanism involving miR-301a sponging and MEOX2 upregulation."	0.6278
40375961	Cytotechnology	2025	PLGA microspheres loaded with si-circETS1 as a therapeutic strategy to delay intervertebral disc degeneration.	hsa_circ_0002083	circETS1	hsa_circ_ETS1	ETS1	intervertebral disc degeneration 	MONDO:0011385	intervertebral disk degenerative disorder	up-regulated	RT-qPCR; ISH; RNA-seq	"This study identified hsa_circ_0002083/circETS1 as an ETS1-derived circRNA up-regulated in severely degenerated human nucleus pulposus tissues and TNF-alpha-induced degenerative NPCs. Functionally, circETS1 appears to aggravate IDD-related NPC dysfunction by suppressing proliferation, promoting apoptosis, and impairing extracellular matrix metabolism, while si-circETS1 delivery using PLGA microspheres suppresses circETS1 and delays IDD progression in vitro and in vivo."	0.8037
40377691	Histochemistry and cell biology	2025	Inhibition of hsa_circ_0003314 contributes to trophoblast cell migration and invasion and inhibits pyroptosis in preeclampsia.	hsa_circ_0003314	hsa_ circ_0003314 			preeclampsia	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR; Microarray	"hsa_circ_0003314 is up-regulated in preeclamptic placental tissues and in H/R-treated HTR-8/SVneo trophoblast cells. It functions as a miR-1827 sponge to promote caspase-5 expression and caspase-5-mediated pyroptosis, while its silencing enhances trophoblast migration, invasion, and EMT. The study proposes hsa_circ_0003314 as a potential therapeutic target for preeclampsia."	0.6853
40381776	International journal of biological macromolecules	2025	A novel DNA binding protein encoded by circZNF131 inhibits the growth of gastric cancer by suppressing CTBP2 transcription.		circZNF131	hsa_circ_ZNF131	ZNF131	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"circZNF131 is downregulated in gastric cancer plasma and tumor tissues, and low expression is associated with poor prognosis. Functionally, circZNF131 suppresses GC cell proliferation, migration, invasion and tumor growth by encoding the IRES-driven protein ZNF131-354aa. Mechanistically, ZNF131-354aa represses CTBP2 transcription to increase E-cadherin and PTEN expression, while TRIM28 promotes ZNF131-354aa ubiquitination and degradation."	0.89
40383466	Archives of biochemistry and biophysics	2025	CircNTRK2 promotes the progression of nasopharyngeal carcinoma via sponging miR-384 to regulate SOX4 expression.	hsa_circ_0139142	circNTRK2	hsa_circ_NTRK2	NTRK2	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; Microarray	"circNTRK2 is up-regulated in NPC tissues and cells and functions as an oncogenic circRNA. It promotes NPC cell proliferation, invasion, EMT, tumor growth and metastasis while inhibiting apoptosis, mainly through a ceRNA mechanism in which it sponges miR-384 to increase SOX4 expression. The study suggests circNTRK2 as a potential therapeutic target for NPC."	0.8439
40384439	"Hypertension (Dallas, Tex. : 1979)"	2025	ca-circSCN8A Promotes HPASMCs Ferroptosis via LLPS Initiated R-Loop.		ca-circSCN8A 	hsa_circ_SCN8A	SCN8A	pulmonary hypertension 	MONDO:0005149	pulmonary hypertension	up-regulated	RT-qPCR	"ca-circSCN8A is up-regulated in pulmonary hypertension-related hypoxic conditions and promotes HPASMC ferroptosis and pulmonary vascular remodeling. Mechanistically, it recruits EP300 and FUS to form LLPS-associated nuclear condensates, stabilizes an R-loop at the nonhost SLC7A11 promoter, represses SLC7A11 transcription, disrupts redox homeostasis, and thereby enhances ferroptosis."	0.8067
40398732	Life sciences	2025	Circ_0002638 drives squamous cell lung cancer (LUSC) progression and chemotherapy resistance by inhibiting ferroptosis via SENP1-mediated deSUMOylation of ACSL4.	hsa_circ_0002638	circ_0002638			squamous cell lung cancer 	MONDO:0005097	squamous cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ_0002638 is upregulated in LUSC and chemotherapy-progressive disease samples, and high expression is associated with poor prognosis. It promotes tumor proliferation, invasion, metastasis, and chemoresistance by scaffolding SENP1 and ACSL4, promoting ACSL4 deSUMOylation and suppressing ACSL4-mediated ferroptosis."	0.8711
40398791	International journal of biological macromolecules	2025	IGF2BP3-regulated circPLEKHH2 promotes autophagy via AKT/mTOR signaling pathway to suppress lung adenocarcinoma progression.	hsa_circ_0120106	circPLEKHH2 	hsa_circ_PLEKHH2	PLEKHH2	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; RNA-seq	"circPLEKHH2 is significantly downregulated in LUAD and functions as a tumor suppressor. It promotes autophagy and suppresses LUAD cell proliferation, migration, invasion, and xenograft tumor growth through inhibition of the AKT/mTOR signaling pathway. IGF2BP3 directly binds circPLEKHH2 and inhibits its expression, which may contribute to circPLEKHH2 downregulation in LUAD."	0.8554
40409108	International immunopharmacology	2025	METTL3-mediated m6A modification of circCSDE1 promote Coxsackievirus replication by regulating the miR-891b/BAG3 axis.	hsa_circ_0000115	circCSDE1	hsa_circ_CSDE1	CSDE1	Coxsackievirus infection 	MONDO:0005721	coxsackievirus infectious disease	up-regulated	RT-qPCR	"hsa_circ_0000115/circCSDE1 is induced and up-regulated during CVB3 and CVA16 infection and in CVB3-induced myocarditis tissue. METTL3-mediated m6A modification promotes circCSDE1 biogenesis/stability, while cytoplasmic circCSDE1 sponges miR-891b to increase BAG3 expression, activate autophagy, and enhance viral replication. Silencing circCSDE1 suppresses autophagosome formation and viral replication, suggesting therapeutic potential for enteroviral infections."	0.8012
40409233	"Clinical nutrition (Edinburgh, Scotland)"	2025	CiR-EIS alleviates metabolic dysfunction-associated steatohepatitis by modulating macrophage polarization involving the miR-548m/IGF1 axis.	hsa_circ_0008882	ciR-EIS 	hsa_circ_MT-ND5	MT-ND5	metabolic dysfunction-associated steatohepatitis 	MONDO:0007027	metabolic dysfunction-associated steatohepatitis	down-regulated	RT-qPCR; ISH	"CiR-EIS is a human circRNA downregulated in MASH liver/plasma and in M1 macrophages, while elevated in M2 macrophages. It functions as a cytoplasmic miR-548m sponge to regulate IGF1, suppressing pro-inflammatory M1 polarization and promoting M2 polarization, which reduces hepatocyte lipid accumulation and stellate cell proliferation. Clinically, lower ciR-EIS correlates with MASH and fibrosis-related indices, suggesting diagnostic and therapeutic potential."	0.8162
40412523	The Journal of biological chemistry	2025	Circular RNA-OGDH promotes PANoptosis in diabetic cardiomyopathy: A novel mechanistic insight.		circOGDH 	mmu_circ_OGDH	OGDH	diabetic cardiomyopathy 	MONDO:0004994	cardiomyopathy	up-regulated	RT-qPCR; RNA-seq	"circOGDH is up-regulated in diabetic cardiomyopathy models and high-glucose/palmitate-treated cardiomyocytes. It promotes PANoptosis and pathological cardiac injury by binding HMGB1 and enhancing RIPK3 signaling; circOGDH knockdown improves cardiac function, reduces fibrosis, and suppresses PANoptosis-related protein expression."	0.8104
40415425	Nan fang yi ke da xue xue bao = Journal of Southern Medical University	2025	[Circ_EPHB4 regulates temozolomide sensitivity in glioma cells through the miR-424-5p/Wnt3 axis].		circ_EPHB4 	hsa_circ_EPHB4	EPHB4	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR	circ_EPHB4 is up-regulated in TMZ-resistant glioma tissues and cells. It promotes clonogenic growth and chemoresistance while inhibiting apoptosis by sponging miR-424-5p and increasing Wnt3 expression. Knockdown of circ_EPHB4 enhances TMZ sensitivity in vitro and suppresses xenograft tumor growth in vivo.	0.7045
40418306	Journal of molecular histology	2025	Circ_0008285 regulates macrophage polarization through miR-375/MAPK14 axis in sepsis-induced acute lung injury.	hsa_circ_0008285	Circ_0008285 	hsa_circ_CDYL	CDYL	sepsis-induced acute lung injury 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR	"This study found that circ_0008285 is up-regulated in LPS-treated macrophages and CLP-induced sepsis-ALI mouse lung tissue. Functionally, circ_0008285 promotes inflammatory macrophage polarization, epithelial cell injury/apoptosis, and lung damage, while its knockdown alleviates these phenotypes. Mechanistically, circ_0008285 acts through the miR-375/MAPK14 axis and may represent a therapeutic target for sepsis-induced ALI."	0.5634
40419081	Cancer letters	2025	Therapeutic targeting of circTNK2 with nanoparticles restores tamoxifen sensitivity and enhances NK cell-mediated immunity in ER-positive breast cancer.		circTNK2 	hsa_circ_TNK2	TNK2	estrogen receptor-positive breast cancer 	MONDO:0006512	estrogen-receptor positive breast cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circTNK2 is up-regulated in tamoxifen-resistant ER-positive breast cancer and is associated with poor prognosis. It acts through dual mechanisms: its encoded peptide C-TNK2-487aa promotes STAT3 phosphorylation and suppresses STAT1-dependent CXCL10 expression to reduce NK cell recruitment, while circTNK2 RNA binds SRSF1 to activate AKT/mTOR signaling and drive proliferation and tamoxifen resistance. Nanoparticle-mediated delivery of circTNK2 ASO with CXCL10 pDNA suppresses tumor growth, restores tamoxifen sensitivity, and enhances NK-cell infiltration."	0.9023
40419818	Journal of molecular histology	2025	hsa_circ_0001103 correlates with unfavorable MRI features and promotes glioma progression by modulating the miR-375/YAP1 axis.	hsa_circ_0001103	circ_0001103			glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001103/circ_0001103 is up-regulated in glioma tissues and cell lines and is associated with larger tumor size and heterogeneous MRI signals. Functionally, it promotes glioma cell proliferation and suppresses apoptosis. Mechanistically, it acts through the miR-375/YAP1 axis by adsorbing miR-375 and positively regulating YAP1 expression."	0.7295
40435734	The Science of the total environment	2025	Loss of circular EYA3 attenuates formaldehyde-induced cardiomyocyte pyroptosis and congenital heart defects by regulating Smad5 stability.		rno_circ_009926 	rno_circ_EYA3	EYA3	congenital heart disease 	MONDO:0005453	congenital heart disease	up-regulated	RT-qPCR; RNA-seq	"circEYA3 is up-regulated in FA-exposed fetal rat heart tissue and in blood from pregnant women with FA exposure whose fetuses had CHD. Functionally, circEYA3 promotes FA-induced cardiomyocyte pyroptosis, while circEYA3 knockdown attenuates pyroptosis and improves abnormal fetal heart development. Mechanistically, circEYA3 binds Smad5 and facilitates Smurf1-mediated ubiquitination-dependent degradation of Smad5."	0.8739
40436287	Cellular signalling	2025	Aerobic exercise alleviates chronic allergic airway inflammation by regulating the circMETTL9/EIF4A3/IGFBP3 axis.		circMETTL9 	hsa_circ_METTL9	METTL9	asthma 	MONDO:0004979	asthma	up-regulated	RT-qPCR; ISH	"circMETTL9 is up-regulated in chronic allergic airway inflammation/asthma models and is reduced by aerobic exercise. Functionally, circMETTL9 promotes airway inflammation/remodeling and increases airway epithelial cell proliferation, apoptosis, and oxidative stress. Mechanistically, circMETTL9 binds EIF4A3 and inhibits IGFBP3 transcription and translation, forming a circMETTL9/EIF4A3/IGFBP3 axis that mediates the protective effects of aerobic exercise."	0.7302
40436287	Cellular signalling	2025	Aerobic exercise alleviates chronic allergic airway inflammation by regulating the circMETTL9/EIF4A3/IGFBP3 axis.		circMETTL9 	mmu_circ_METTL9	METTL9	asthma 	MONDO:0004979	asthma	up-regulated	RT-qPCR; ISH	"circMETTL9 is up-regulated in chronic allergic airway inflammation/asthma models and is reduced by aerobic exercise. Functionally, circMETTL9 promotes airway inflammation/remodeling and increases airway epithelial cell proliferation, apoptosis, and oxidative stress. Mechanistically, circMETTL9 binds EIF4A3 and inhibits IGFBP3 transcription and translation, forming a circMETTL9/EIF4A3/IGFBP3 axis that mediates the protective effects of aerobic exercise."	0.7302
40444442	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2025	circ_0005654 as a Sponge of the miR-588 Dual Pathway to Promote alpha-Synuclein Expression.	hsa_circ_0005654	circ_0005654 	hsa_circ_PRDM5	PRDM5	Parkinson's disease 	MONDO:0005180	Parkinson disease	up-regulated	RNA-seq; Microarray	"circ_0005654 is up-regulated in peripheral blood of PD patients and is derived from the PRDM5 gene. In cellular PD models, it acts as a miR-588 sponge to promote alpha-Syn mRNA/protein expression and suppress alpha-Syn clearance through the miR-588/p62 autophagy pathway, contributing to alpha-Syn accumulation and aggregation. The study suggests circ_0005654 has diagnostic potential and may be a therapeutic target for PD."	0.8193
40444888	Journal of investigative medicine : the official publication of the American Federation for Clinical Research	2025	Understanding the correlation of IL-6 with circRNA-DLGAP4 in the pathogenesis and diagnosis of rheumatoid arthritis.		circRNA-DLGAP4 	hsa_circ_DLGAP4	DLGAP4	rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	This study found that serum circRNA-DLGAP4 is significantly up-regulated in rheumatoid arthritis patients compared with healthy controls. Its level increases with disease severity and shows diagnostic potential for RA based on ROC analysis. No direct mechanistic circRNA-miRNA or circRNA-protein axis was experimentally validated in this study.	0.4187
40460641	"Pathology, research and practice"	2025	Exosomal circUBQLN1 facilitates M2 polarization of macrophages and enhances colorectal cancer progression by modulating the miR-34c-5p/CSF1R axis.		circUBQLN1 	hsa_circ_UBQLN1	UBQLN1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circUBQLN1 is up-regulated in CRC tissues, CRC cell lines, CRC-derived exosomes, and TAMs exposed to CRC-derived exosomes. CRC cell-derived exosomal circUBQLN1 promotes TAM M2 polarization by sponging miR-34c-5p and derepressing CSF1R, thereby enhancing CRC cell growth, migration, invasion, and metastasis."	0.7289
40474527	Advances in clinical and experimental medicine : official organ Wroclaw Medical University	2025	Circular RNA hsa_circ_0008433 drives vascular smooth muscle cell modulation in intracranial aneurysm pathogenesis.	hsa_circ_0008433	circ_0008433			intracranial aneurysm 	MONDO:0005291	brain aneurysm	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0008433 is up-regulated in intracranial aneurysm tissues, particularly ruptured aneurysms. Functionally, it promotes HBVSMC proliferation, migration, and phenotype switching toward a pro-inflammatory/matrix-remodeling state marked by increased MMP-2/MMP-9 and decreased alpha-SMA/SM22alpha. The study suggests hsa_circ_0008433 may contribute to aneurysm instability and may have biomarker or therapeutic-target potential."	0.5358
40493341	Cell biochemistry and biophysics	2025	Bladder Cancer Growth is Inhibited by Upregulating CircFUT8 through the METTL14/FMR1 Signaling Pathway.	hsa_circ_0003028	circFUT8	hsa_circ_FUT8	FUT8	Bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR	"circFUT8 is significantly downregulated in bladder cancer tissues and functions as a tumor-suppressive circRNA. METTL14 promotes circFUT8 m6A methylation and expression, while the m6A reader/RBP FMR1 directly binds circFUT8 and enhances its expression; activation of this METTL14/FMR1/circFUT8 axis inhibits BCa cell proliferation, migration, and tumor growth."	0.7078
40493902	"Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer"	2025	Identifying circRNA-miRNA-mRNA Networks Associated with Osimertinib Resistance in Lung Adenocarcinoma by Analyzing Microarray Datasets.	hsa_circ_0078465				lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0078465 is upregulated in lung adenocarcinoma and further upregulated in osimertinib-resistant lung adenocarcinoma cells. The study validates a hsa_circ_0078465/miR-183-5p/NRAS ceRNA axis that promotes proliferation, migration, invasion, and osimertinib resistance in LUAD cells."	0.642
40493902	"Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer"	2025	Identifying circRNA-miRNA-mRNA Networks Associated with Osimertinib Resistance in Lung Adenocarcinoma by Analyzing Microarray Datasets.	hsa_circ_0043230				lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	dysregulated	Microarray	hsa_circ_0043230 was identified through GEO microarray dataset analysis as a differentially expressed circRNA associated with osimertinib resistance in LUAD. Its individual regulatory partners and biological functions were not experimentally validated in this paper.	0.1768
40493902	"Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer"	2025	Identifying circRNA-miRNA-mRNA Networks Associated with Osimertinib Resistance in Lung Adenocarcinoma by Analyzing Microarray Datasets.	hsa_circ_0023569				lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	dysregulated	Microarray	hsa_circ_0023569 was identified through GEO microarray dataset analysis as a differentially expressed circRNA associated with osimertinib resistance in LUAD. Its individual regulatory partners and biological functions were not experimentally validated in this paper.	0.1768
40493902	"Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer"	2025	Identifying circRNA-miRNA-mRNA Networks Associated with Osimertinib Resistance in Lung Adenocarcinoma by Analyzing Microarray Datasets.	hsa_circ_0057582				lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	dysregulated	Microarray	hsa_circ_0057582 was identified through GEO microarray dataset analysis as a differentially expressed circRNA associated with osimertinib resistance in LUAD. Its individual regulatory partners and biological functions were not experimentally validated in this paper.	0.1768
40493902	"Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer"	2025	Identifying circRNA-miRNA-mRNA Networks Associated with Osimertinib Resistance in Lung Adenocarcinoma by Analyzing Microarray Datasets.	hsa_circ_0006440				lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	dysregulated	Microarray	hsa_circ_0006440 was identified through GEO microarray dataset analysis as a differentially expressed circRNA associated with osimertinib resistance in LUAD. Its individual regulatory partners and biological functions were not experimentally validated in this paper.	0.1768
40493902	"Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer"	2025	Identifying circRNA-miRNA-mRNA Networks Associated with Osimertinib Resistance in Lung Adenocarcinoma by Analyzing Microarray Datasets.	hsa_circ_0091382				lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	dysregulated	Microarray	hsa_ circ_0091382 was identified through GEO microarray dataset analysis as a differentially expressed circRNA associated with osimertinib resistance in LUAD. Its individual regulatory partners and biological functions were not experimentally validated in this paper.	0.1768
40494434	Life sciences	2025	CircRSF1: A potential diagnostic biomarker for primary Sj_gren's syndrome.	hsa_circ_0000344	CircRSF1	hsa_circ_RSF1	RSF1	Primary Sj_gren's syndrome 	MONDO:0010030	Sjogren syndrome	down-regulated	RT-qPCR; RNA-seq	"CircRSF1 is a human circRNA derived from RSF1 that is significantly down-regulated in PBMCs and LSGs from pSS patients. The study supports its potential as a pSS-specific diagnostic biomarker and predicts that it may function through cytoplasmic miRNA sponge activity, CircRSF1-miRNA-mRNA regulation, protein/RBP interactions, and m6A-related mechanisms affecting immune and inflammatory pathways."	0.6981
40494434	Life sciences	2025	CircRSF1: A potential diagnostic biomarker for primary Sj_gren's syndrome.	hsa_circ_0002566				Primary Sj_gren's syndrome 	MONDO:0010030	Sjogren syndrome	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0002566 is a human circRNA significantly down-regulated in PBMCs and LSGs from pSS patients and validated by RT-qPCR. It showed diagnostic ROC performance for pSS, but unlike CircRSF1 it was also differentially expressed in SLE and RA, indicating limited pSS specificity in this study."	0.4679
40503776	Journal of biochemical and molecular toxicology	2025	Hsa_circ_0049271 Facilitates Esophageal Squamous Cell Carcinoma Progression and Cisplatin Resistance by Enhancing Cellular Senescence via miR-455-5p/ETS1.	hsa_circ_0049271				esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0049271 is up-regulated in ESCC and further elevated after cisplatin-induced senescence. It promotes ESCC proliferation, migration, invasion, SASP secretion, cellular senescence, and cisplatin resistance through the miR-455-5p/ETS1 axis, while its knockdown restores DDP sensitivity."	0.6815
40505000	Laboratory medicine	2025	"Evaluation of CD73, PD-1, circHIPK3, and circNRIP1 expression in the peripheral blood of patients with colorectal cancer."	hsa_circ_0000284	circHIPK3	hsa_circ_HIPK3	HIPK3	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"In this study, circHIPK3 was measured in peripheral blood from CRC patients and healthy controls. Its absolute expression was higher but not statistically significant, while the circHIPK3:linHIPK3 ratio was significantly increased, suggesting elevated circularization and potential value as a blood biomarker for CRC."	0.2995
40505000	Laboratory medicine	2025	"Evaluation of CD73, PD-1, circHIPK3, and circNRIP1 expression in the peripheral blood of patients with colorectal cancer."	hsa_circ_0004771	circNRIP1	hsa_circ_NRIP1	NRIP1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"In this study, circNRIP1 was measured in peripheral blood from CRC patients and healthy controls. Its absolute expression was higher but not statistically significant, while the circNRIP1:linNRIP1 ratio was significantly increased; circNRIP1 expression was also significantly associated with family history, age, and disease grade, supporting potential blood biomarker relevance in CRC."	0.2995
40505930	International journal of biological macromolecules	2025	circADARB1 enhances ZEB1 expression in an m6A-dependent manner to promote the invasion and migration of nasopharyngeal carcinoma.		circADARB1 	hsa_circ_ADARB1	ADARB1	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; ISH	"circADARB1 functions as an oncogenic circRNA in nasopharyngeal carcinoma by promoting EMT, invasion, migration, and lung metastasis. Mechanistically, it binds ZEB1 mRNA and interacts with YBX1 to facilitate YBX1 recognition of m6A-modified ZEB1 mRNA, increasing ZEB1 mRNA stability and protein expression. Its elevated expression is associated with poor clinical outcomes and it is proposed as a potential biomarker and therapeutic target in NPC."	0.8811
40513741	International journal of biological macromolecules	2025	Exploring the protective mechanism of Lentinus edodes mycelia polysaccharide against AGEs-induced HUVECs damage: Insights from whole transcriptome sequencing and cell biology techniques.		ZNF609	hsa_circ_ZNF609	ZNF609	AGEs-induced HUVECs damage 	MONDO:0005015	diabetes mellitus	down-regulated	RT-qPCR; RNA-seq	"ZNF609 was identified as the circRNA component of a ceRNA-related regulatory axis in AGEs-induced HUVEC damage. It was down-regulated after AGEs injury and restored by LMP treatment, and the proposed ZNF609/MSTRG.35979-miR-483-3p-RAPGEF1 axis may inhibit p38MAPK-associated inflammation and mitochondrial apoptosis."	0.4375
40513741	International journal of biological macromolecules	2025	Exploring the protective mechanism of Lentinus edodes mycelia polysaccharide against AGEs-induced HUVECs damage: Insights from whole transcriptome sequencing and cell biology techniques.		Circ_006668			AGEs-induced HUVECs damage 	MONDO:0005015	diabetes mellitus	dysregulated	RT-qPCR; RNA-seq	"Circ_006668 was one of four differentially expressed circRNAs selected for qPCR validation in AGEs-treated HUVECs. The article did not report a specific mechanism, interaction partner, or disease-related function for this circRNA."	0.329
40513741	International journal of biological macromolecules	2025	Exploring the protective mechanism of Lentinus edodes mycelia polysaccharide against AGEs-induced HUVECs damage: Insights from whole transcriptome sequencing and cell biology techniques.		Circ_021633			AGEs-induced HUVECs damage 	MONDO:0005015	diabetes mellitus	dysregulated	RT-qPCR; RNA-seq	"Circ_021633 was one of four differentially expressed circRNAs selected for qPCR validation in AGEs-treated HUVECs. The article did not report a specific mechanism, interaction partner, or disease-related function for this circRNA."	0.329
40513741	International journal of biological macromolecules	2025	Exploring the protective mechanism of Lentinus edodes mycelia polysaccharide against AGEs-induced HUVECs damage: Insights from whole transcriptome sequencing and cell biology techniques.		Circ_020465			AGEs-induced HUVECs damage 	MONDO:0005015	diabetes mellitus	dysregulated	RT-qPCR; RNA-seq	"Circ_020465 was one of four differentially expressed circRNAs selected for qPCR validation in AGEs-treated HUVECs. The article did not report a specific mechanism, interaction partner, or disease-related function for this circRNA."	0.329
40520857	American journal of cancer research	2025	"Circular RNA hsa_circ_103089 modulates metabolic glycolysis and influences migration, invasion, and cisplatin sensitivity in non-small cell lung cancer cells via the miR-876-5p/EGFR axis."		hsa_circ_103089	hsa_circ_PCSK6	PCSK6	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"hsa_circ_103089 is upregulated in NSCLC tissues and cell lines and is associated with poorer overall survival. Functionally, it promotes malignant phenotypes, glycolysis, tumor growth, and cisplatin resistance. Mechanistically, it sponges miR-876-5p to enhance EGFR expression and downstream ERK/PKM2-mediated glycolytic regulation."	0.8659
40521053	Cytotechnology	2025	Circular RNA-Sirt1 sponges miR-27b-3p to protect vascular smooth muscle cell injury during atherosclerosis through regulating the glutamine metabolism pathway.	hsa_circ_0093887	circSirt1 	hsa_circ_SIRT1	SIRT1	atherosclerosis 	MONDO:0005311	atherosclerosis	down-regulated	RT-qPCR	"circSirt1 is down-regulated in VSMCs from atherosclerosis patients and under oxidative stress. Its overexpression protects AoSMCs/VSMCs from oxidative stress-induced injury and apoptosis by sponging miR-27b-3p, increasing GLS expression, and restoring glutamine metabolism. The circSirt1-miR-27b-3p-GLS axis is proposed as a potential therapeutic mechanism for maintaining VSMC homeostasis in atherosclerosis."	0.6996
40522194	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2025	CircRAPGEF5 Promotes LUAD by Mediating the HOXC6 Stability.		circRAPGEF5 	hsa_circ_RAPGEF5	RAPGEF5	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circRAPGEF5 is up-regulated in LUAD and acts as an oncogenic circRNA. Its knockdown suppresses LUAD proliferation, migration, invasion, tumor growth, and metastasis. Mechanistically, circRAPGEF5 binds HNRNPC to stabilize HOXC6 mRNA, thereby enhancing HOXC6 expression and downstream HOXB2 transcription."	0.7981
40527976	Journal of molecular histology	2025	EIF4A3-Mediated downregulation of circPTEN promotes hepatocellular carcinoma progression through the miR-1289/RBM38 Axis.		circPTEN 	hsa_circ_PTEN	PTEN	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"circPTEN is downregulated in HCC tissues and low expression is associated with poorer survival and aggressive clinicopathological features. Functionally, circPTEN suppresses HCC proliferation, migration, invasion, EMT, tumor growth, and metastasis. Mechanistically, EIF4A3 negatively regulates circPTEN biogenesis, while circPTEN acts as a miR-1289 sponge to relieve suppression of RBM38."	0.8066
40528379	Journal of applied toxicology : JAT	2025	A Novel Regulatory Network of Noncoding RNAs in the Cadmium-Induced Malignant Transformation of Human Bronchial Epithelial Cells.		circ_000877	hsa_circ_ACSF3	ACSF3	Cd-induced malignant transformation of human bronchial epithelial cells 	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; RNA-seq	"circ_000877 is upregulated in cadmium-induced malignant transformed 16HBE cells. It promotes malignant transformation by acting with lnc237177 to bind and negatively regulate miR-3192-5p, thereby increasing CCND1 and MMP-2 expression and enhancing migration/proliferative malignant phenotypes."	0.6731
40531429	Journal of applied genetics	2025	Exploring the role of circRNA-miRNA-mRNA interactions in cervical cancer progression: insights into HPV status and potential therapeutic approaches.		circRNA4806 	hsa_circ_KIAA1191	KIAA1191	cervical cancer 	MONDO:0002974	cervical cancer	down-regulated	RNA-seq	"circRNA4806/hsa-KIAA1191_0001 was identified as a down-regulated DE circRNA during cervical cancer progression. It was predicted to function as a ceRNA for hsa-miR-31-5p and to interact with multiple RBPs, but it was not experimentally validated by qRT-PCR in this study."	0.1768
40531429	Journal of applied genetics	2025	Exploring the role of circRNA-miRNA-mRNA interactions in cervical cancer progression: insights into HPV status and potential therapeutic approaches.		circRNA4400 	hsa_circ_ESR1	ESR1	cervical cancer 	MONDO:0002974	cervical cancer	down-regulated	RNA-seq	"circRNA4400/hsa-ESR1_0014 was identified as a down-regulated DE circRNA in HSIL and CSCC relative to HPV-positive normal cervical epithelium. It was predicted to interact with hsa-miR-132-5p, hsa-miR-143-5p and hsa-miR-128-1-5p, with the hsa-ESR1_0014-hsa-miR-143-5p pair proposed to affect lipid metabolism and fatty acid synthesis."	0.1768
40531429	Journal of applied genetics	2025	Exploring the role of circRNA-miRNA-mRNA interactions in cervical cancer progression: insights into HPV status and potential therapeutic approaches.		circRNA4402 	hsa_circ_ESR1	ESR1	cervical cancer 	MONDO:0002974	cervical cancer	down-regulated	RNA-seq	circRNA4402/hsa-ESR1_0005 was identified as a down-regulated DE circRNA in cervical cancer progression. It was predicted to bind hsa-miR-24-3p and hsa-miR-96-3p and to participate in a broader circRNA-miRNA-mRNA ceRNA network.	0.1768
40531429	Journal of applied genetics	2025	Exploring the role of circRNA-miRNA-mRNA interactions in cervical cancer progression: insights into HPV status and potential therapeutic approaches.		circRNA46029 	hsa_circ_ZFAND6	ZFAND6	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RNA-seq	circRNA46029/hsa-ZFAND6_0003 was identified as an up-regulated DE circRNA during cervical cancer progression. It was predicted to interact with hsa-miR-22-5p and multiple RBPs and may influence transcriptomic regulation through ceRNA or ribonucleoprotein-complex-related mechanisms.	0.1768
40531429	Journal of applied genetics	2025	Exploring the role of circRNA-miRNA-mRNA interactions in cervical cancer progression: insights into HPV status and potential therapeutic approaches.		circRNA46229 	hsa_circ_ZNF532	ZNF532	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RNA-seq	"circRNA46229/hsa-ZNF532_0016 was identified as a DE circRNA in cervical cancer progression. Unlike the other DE circRNAs, it had no predicted miRNA partner and was proposed to act through predicted RBP interactions that may affect transcriptional, post-transcriptional, or translational regulation."	0.1768
40531429	Journal of applied genetics	2025	Exploring the role of circRNA-miRNA-mRNA interactions in cervical cancer progression: insights into HPV status and potential therapeutic approaches.		circRNA46342 	hsa_circ_TTC3	TTC3	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RNA-seq	circRNA46342/hsa-TTC3_0004 was identified as an up-regulated DE circRNA and predicted to bind hsa-miR-22-5p. The study proposed that this interaction may alter ribonucleoprotein complexes and the cellular transcriptome in cervical cancer progression.	0.1768
40531429	Journal of applied genetics	2025	Exploring the role of circRNA-miRNA-mRNA interactions in cervical cancer progression: insights into HPV status and potential therapeutic approaches.		circRNA45436 	hsa_circ_KIF4A	KIF4A	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; RNA-seq	"hsa-KIF4A_0022/hsa-KIF4 A_0022 was the key experimentally validated circRNA in this study. It was up-regulated in cervical cancer tissues and formed a positive ceRNA network with hsa-miR-29b-2-5p and UBE2D2, with potential implications for cervical cancer progression, fatty acid/lipid synthesis, and therapeutic targeting."	0.4032
40531429	Journal of applied genetics	2025	Exploring the role of circRNA-miRNA-mRNA interactions in cervical cancer progression: insights into HPV status and potential therapeutic approaches.		circRNA4746 	hsa_circ_SP1	SP1	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RNA-seq	circRNA4746/hsa-SP1_00031 was identified as an up-regulated DE circRNA in CSCC relative to HPV-positive and HPV-negative normal cervical epithelium. It was predicted to function in the ceRNA network through several miRNAs and to interact with many RBPs.	0.1768
40531429	Journal of applied genetics	2025	Exploring the role of circRNA-miRNA-mRNA interactions in cervical cancer progression: insights into HPV status and potential therapeutic approaches.		circRNA873 	hsa_circ_CRY2	CRY2	cervical cancer 	MONDO:0002974	cervical cancer	down-regulated	RNA-seq	"circRNA873/hsa-CRY2_0002 was identified as down-regulated in CSCC compared with both HPV-positive and HPV-negative normal cervical epithelium. It was included among the predicted DE circRNA-miRNA network members, although the supplied text does not specify its miRNA or RBP partners."	0.1768
40531429	Journal of applied genetics	2025	Exploring the role of circRNA-miRNA-mRNA interactions in cervical cancer progression: insights into HPV status and potential therapeutic approaches.		circRNA7194 	hsa_circ_CDKN2B-AS1	CDKN2B-AS1	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RNA-seq	circRNA7194/hsa-CDKN2B-AS1_0004 was up-regulated in CSCC compared with HPV-positive and HPV-negative normal cervical epithelium. It was predicted to participate in a distinct CDKN2B-AS1-miR-126-5p ceRNA network.	0.1768
40531429	Journal of applied genetics	2025	Exploring the role of circRNA-miRNA-mRNA interactions in cervical cancer progression: insights into HPV status and potential therapeutic approaches.		circRNA12542 	hsa_circ_CDKN2B-AS1	CDKN2B-AS1	cervical cancer 	MONDO:0002974	cervical cancer	up-regulated	RNA-seq	circRNA12542/hsa-CDKN2B-AS1_0002 was up-regulated in CSCC compared with HPV-positive and HPV-negative normal cervical epithelium. It formed a separate predicted ceRNA connection with hsa-miR-126-5p and was highlighted as a crucial circRNA/network component in cervical cancer progression.	0.1768
40532817	Cancer letters	2025	CircSRPK1 mediated by the exon junction complex promotes gastric cancer progression by interacting with hnRNP A2B1 to regulate RON mRNA alternative splicing.	hsa_circ_0076168	circSRPK1	hsa_circ_SRPK1	SRPK1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; ISH	"circSRPK1 is an SRPK1-derived human circRNA upregulated in gastric cancer tissues and cell lines. It promotes GC proliferation, tumorigenesis, migration, invasion and metastasis by interacting with hnRNP A2B1 to regulate RON mRNA alternative splicing and induce RONdelta160 formation, while its production is enhanced by the upstream MAGOH/EIF4A3 axis. High circSRPK1 expression is associated with advanced disease features and poor overall survival."	0.8889
40534305	Cancer biomarkers : section A of Disease markers	2025	Hsa_circ_0101308 adjusted by N6-methyladenosine (m6A) impacts chemo-resistance in cervical cancer via sponging miR-224.	hsa_circ_0101308				cervical cancer 	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR	"hsa_circ_0101308 is down-regulated in cervical cancer tissues and cell lines. The study indicates that m6A-adjusted hsa_circ_0101308 suppresses drug-resistant cervical cancer cell viability and chemo-resistance by sponging miR-224, thereby affecting the miR-224/CADM1/PI3K-AKT pathway. Clinically, higher hsa_circ_0101308 expression is associated with favorable pathological features and better 2-year overall survival."	0.7682
40541877	International journal of biological macromolecules	2025	CircSETD3 interrupts the bidirectional positive feedback of ErbB3 and Akt by sponging miR-4667-5p to inhibit colorectal cancer progression and cetuximab resistance.	hsa_circ_0000567	circ-SETD3 	hsa_circ_SETD3	SETD3	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"circSETD3 is downregulated in colorectal cancer and acts as a tumor suppressor. It sponges miR-4667-5p to restore RASA4 expression, thereby suppressing the ErbB3/Akt positive feedback loop, inhibiting proliferation, migration, growth and metastasis, and enhancing cetuximab sensitivity. Clinically, low circSETD3 expression is associated with lymphatic metastasis, advanced TNM stage and poor overall survival."	0.8157
40543775	International journal of biological macromolecules	2025	CircTBCD/IGF2BP2 complex stabilizes IGF-1R mRNA in an m6A-dependent manner to promote bone metastasis in nasopharyngeal carcinoma.	hsa_circ_0005245	circTBCD	hsa_circ_TBCD	TBCD	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; RNA-seq	"circTBCD is an upregulated circRNA in NPC bone metastasis and high expression is associated with poorer survival. It promotes NPC proliferation, migration, tumor growth, and bone metastasis by cooperating with IGF2BP2 and METTL3 to stabilize IGF-1R mRNA through an m6A-dependent mechanism. Targeting circTBCD with ASO suppresses NPC bone metastasis in vivo, supporting its potential as a prognostic biomarker and therapeutic target."	0.8876
40545108	International journal of biological macromolecules	2025	circGAPVD1 inhibits the progression of gastric cancer through miR-4424/STK4 axis and encoding GAPVD1-137aa protein.	hsa_circ_0003270	circGAPVD1 	hsa_circ_GAPVD1	GAPVD1	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"circGAPVD1 is a human GAPVD1-derived circRNA downregulated in gastric cancer tissues and cell lines. It suppresses GC progression by sponging miR-4424 to regulate STK4, encoding the tumor-suppressive GAPVD1-137aa protein, and inhibiting SMAD signaling, thereby reducing proliferation, migration, invasion, EMT, inflammation, and tumor growth while promoting apoptosis. Clinically, higher circGAPVD1 expression is associated with better overall survival and lower tumor size/TNM stage."	0.8557
40554999	Biochemical and biophysical research communications	2025	Hyaluronic acid-functionalized PLGA nanoparticles loaded with circSNX6 siRNA overcome sunitinib resistance in renal cell carcinoma.		circSNX6	hsa_circ_SNX6		renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	up-regulated	RNA-seq	"This study investigated circSNX6 as a therapeutic target for sunitinib-resistant renal cell carcinoma. HA-PLGA nanoparticles carrying circSNX6 siRNA sensitized resistant RCC cells to sunitinib, promoted apoptosis, altered mitochondrial organization-related programs, and inhibited tumor growth in a xenograft model. The paper also links circSNX6 to the miR-1184/GPCPD1/LPA axis and poor clinical outcomes in RCC patients."	0.4611
40555339	Toxicology letters	2025	circ_0000554 promotes macrophage M2 polarization mediated by glycolytic reprogramming and aggravates COPD injury.	hsa_circ_0000554		hsa_circ_LIN52	LIN52	chronic obstructive pulmonary disease 	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000554/circ_0000554 is up-regulated in COPD patients exposed to PM 2.5 and in PM 2.5-induced COPD models. It functions as a cytoplasmic ceRNA by sponging miR-548b-3p to activate SLC2A3, thereby promoting glycolytic reprogramming, macrophage M2 polarization, MMP9/MMP12 expression, and COPD lung injury."	0.7785
40557815	Journal of biochemical and molecular toxicology	2025	Inhibition of circ_0127646 Enhanced the Cisplatin Sensitivity in Osteosarcoma Cells via miR-22/KAT6B Axis.	hsa_circ_0127646				osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ_0127646 is up-regulated in osteosarcoma cell lines after cisplatin treatment and is associated with reduced cisplatin sensitivity. Its inhibition enhances cisplatin-induced apoptosis and suppresses clonogenic growth through the miR-22/KAT6B axis, downregulating S100A8, S100A9, PDGF, and VEGF and inhibiting PI3K/Akt/mTOR signaling. The study proposes circ_0127646 as a potential biomarker and therapeutic target for cisplatin-based treatment in osteosarcoma."	0.5607
40576533	Minerva cardiology and angiology	2025	The diagnostic and functional values of circFOXP1 in acute myocardial infarction.		circFOXP1 	hsa_circ_FOXP1	FOXP1	acute myocardial infarction 	MONDO:0004781	acute myocardial infarction	down-regulated	RT-qPCR	"circFOXP1 is downregulated in acute myocardial infarction patients and showed diagnostic value with an ROC AUC of 0.881. Functionally, circFOXP1 overexpression protects H/R-stressed AC16 cells and AMI mice by reducing apoptosis, inflammation, and oxidative stress. The study supports a circFOXP1/miR-9-3p mechanism in AMI-related heart injury."	0.7126
40578478	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association	2025	Role of circular RNAs in formaldehyde-induced lung Injury: Insights into expression and regulatory pathways.		rno_circRNA_010133 			formaldehyde-induced lung injury 	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR; Microarray	rno_circRNA_010133 is up-regulated in formaldehyde-exposed rat lung tissue and is implicated in formaldehyde-induced lung injury. The study supports a ceRNA model in which rno_circRNA_010133 interacts with rno-miR-107 to regulate Atg12 and promote autophagy-related lung epithelial damage.	0.6722
40578478	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association	2025	Role of circular RNAs in formaldehyde-induced lung Injury: Insights into expression and regulatory pathways.		rno_circRNA_016194			formaldehyde-induced lung injury 	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR; Microarray	rno_circRNA_016194 is up-regulated in formaldehyde-exposed rat lung tissue and its expression correlates positively with lung injury measures. No specific miRNA/mRNA regulatory mechanism was validated for this circRNA.	0.516
40578478	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association	2025	Role of circular RNAs in formaldehyde-induced lung Injury: Insights into expression and regulatory pathways.		rno_circRNA_008646 			formaldehyde-induced lung injury 	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR; Microarray	rno_circRNA_008646 is up-regulated in formaldehyde-exposed rat lung tissue and correlates positively with lung injury score and lung weight coefficient. No specific downstream regulatory axis was validated for this circRNA.	0.516
40578478	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association	2025	Role of circular RNAs in formaldehyde-induced lung Injury: Insights into expression and regulatory pathways.		rno_circRNA_002357 			formaldehyde-induced lung injury 	MONDO:0015796	acute lung injury	down-regulated	RT-qPCR; Microarray	"rno_circRNA_002357 is down-regulated in formaldehyde-exposed rat lung tissue. The paper implicates it in a rno-miR-9a-5p/Wnt4/Wnt pathway network, with formaldehyde exposure associated with suppression of Wnt4 and beta-catenin proteins."	0.593
40578478	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association	2025	Role of circular RNAs in formaldehyde-induced lung Injury: Insights into expression and regulatory pathways.		rno_circRNA_004857 			formaldehyde-induced lung injury 	MONDO:0015796	acute lung injury	down-regulated	RT-qPCR; Microarray	"rno_circRNA_004857 is down-regulated in formaldehyde-exposed rat lung tissue and correlates negatively with lung injury score and lung weight coefficient. No specific interacting miRNA, target mRNA, or pathway was validated for this circRNA."	0.516
40578478	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association	2025	Role of circular RNAs in formaldehyde-induced lung Injury: Insights into expression and regulatory pathways.		rno_circRNA_002815 			formaldehyde-induced lung injury 	MONDO:0015796	acute lung injury	down-regulated	RT-qPCR; Microarray	rno_circRNA_002815 is down-regulated in formaldehyde-exposed rat lung tissue and correlates negatively with lung injury indices. The study did not validate a specific molecular regulatory mechanism for this circRNA.	0.516
40581264	Cellular signalling	2025	Circ_0084927 promotes progression of intrahepatic cholangiocarcinoma by sponging miR-4725-5p to activate the PDPK1/AKT/mTOR signaling pathway.	hsa_circ_0084927		hsa_circ_ESRP1	ESRP1	intrahepatic cholangiocarcinoma 	MONDO:0003210	intrahepatic cholangiocarcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circ_0084927 is upregulated in ICC tissues and cell lines and high expression predicts poorer prognosis. It promotes ICC proliferation, invasion, migration, metastasis and tumor growth while inhibiting apoptosis through the miR-4725-5p/PDPK1/AKT/mTOR axis. It is also packaged into exosomes from gemcitabine-resistant ICC cells and transfers gemcitabine resistance to sensitive cells."	0.8884
40588510	Acta pharmacologica Sinica	2025	PYRCR alleviates myocardial ischemia/reperfusion injury in mice via inhibiting DRG2-mediated cardiomyocyte pyroptosis.		circRNA_45524 			myocardial ischemia/reperfusion injury 	MONDO:0005203	ischemia reperfusion injury	down-regulated	RT-qPCR; Microarray	"PYRCR is a pyroptosis-associated circRNA that is down-regulated in H/R-treated cardiomyocytes, I/R-injured mouse hearts, and cardiac tissues from heart failure patients. Functionally, PYRCR alleviates myocardial I/R injury by binding DRG2 and blocking DRG2-Drp1 interaction, thereby reducing Drp1 expression, mitochondrial fission, cardiomyocyte pyroptosis, myocardial infarction, and cardiac dysfunction."	0.8143
40601689	Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology	2025	circRNA_BMPR2 affects the progression of polycystic ovary syndrome by regulating the expression of Rab43.	hsa_circ_0003218	circRNA_BMPR2 	hsa_circ_BMPR2	BMPR2	Polycystic Ovary syndrome 	MONDO:0008487	polycystic ovary syndrome	up-regulated	RT-qPCR	circ_BMPR2 is significantly up-regulated in ovarian granulosa cells from PCOS patients. It promotes KGN granulosa cell proliferation and suppresses apoptosis by acting as a ceRNA for miR-619-5p to regulate Rab43 expression. The study proposes circ_BMPR2 as a potential early diagnostic biomarker and mechanistic contributor to PCOS progression.	0.8455
40608140	Molecular biology reports	2025	The possible role of hsa_circ_0049356 and hsa-miR-338-3p in systemic lupus erythematosus disease.	hsa_circ_0049356				systemic lupus erythematosus 	MONDO:0007915	systemic lupus erythematosus	down-regulated	RT-qPCR	"In this case-control clinical study, hsa_circ_0049356 was significantly down-regulated in SLE patients. The authors propose that reduced hsa_circ_0049356 releases its sponge effect on miR-338-3p, increasing miR-338-3p and contributing to SLE pathogenesis through ERK/MAPK pathway alteration. hsa_circ_0049356 is suggested as a potential biomarker for understanding SLE pathophysiology."	0.4128
40608154	Human cell	2025	CircTADA2A inhibits cell proliferation and promotes ferroptosis by sponging miR-638 in acute myeloid leukemia.	hsa_circ_0043278	circTADA2A	hsa_circ_TADA2A	TADA2A	acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	down-regulated	RT-qPCR; Microarray	"circTADA2A is a human circRNA derived from TADA2A and is downregulated in plasma, bone marrow, and AML cell lines. In AML models, circTADA2A suppresses leukemia cell proliferation and facilitates ferroptosis by sponging miR-638, while plasma circTADA2A shows potential diagnostic value and association with cytogenetic risk."	0.8794
40616280	Journal of physiological investigation	2025	CircERBB3 Targets miR-194-5p/PRMT3 to Promote Hepatocellular Carcinoma Progression.	hsa_circ_0098823	circERBB3 	hsa_circ_ERBB3	ERBB3	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"This study identifies circERBB3 as an oncogenic circRNA in HCC cell lines. circERBB3 is upregulated in Huh7 and HepG2 cells and promotes proliferation, invasion, migration, and apoptosis resistance by competitively binding miR-194-5p and thereby increasing PRMT3 expression."	0.5627
40619013	Biochemical pharmacology	2025	CircCHAF1A induced cellular senescence by enhancing the stability of p21 to suppress gastric cancer progression.	hsa_circ_0048607	circCHAF1A 	hsa_circ_CHAF1A	CHAF1A	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"circCHAF1A is a CHAF1A-derived human circRNA that is downregulated in gastric cancer tissues and cell lines. It suppresses gastric cancer progression by sponging miR-370-3p, increasing CDKN1A/p21 expression and mRNA stability, inducing cellular senescence and G1 arrest, and inhibiting proliferation and migration. Clinically, low circCHAF1A expression is linked to poor prognosis, TNM stage, and lymph node metastasis."	0.8684
40619071	Gene	2025	Transcriptomic analysis reveals potential novel circRNA in goiters progression.		mmu-circ-0000554 			goiter 	MONDO:0005397	goiter	up-regulated	RT-qPCR; RNA-seq	"mmu-circ-0000554 was up-regulated in thyroid tissues of iodine deficiency-induced goiter mice and decreased after iodine repletion. The study proposes that it may promote goiter progression through a ceRNA regulatory axis involving miR-363-5p and IGF1, with potential biomarker and therapeutic relevance."	0.4851
40619071	Gene	2025	Transcriptomic analysis reveals potential novel circRNA in goiters progression.	hsa_circ_0030239				goiter 	MONDO:0005397	goiter	up-regulated	RT-qPCR	"hsa-circ-0030239, identified as the human homolog of mmu-circ-0000554, was up-regulated in peripheral blood of adult nodular goiter patients. The study supports a hsa-circ-0030239/miR-363-5p/IGF1 regulatory axis and suggests diagnostic biomarker potential for goiter."	0.559
40654029	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2025	Protein Tyrosine Kinase 2 Circular RNA Promotes Proliferation and Invasion of Bladder Cancer.	hsa_circ_0003221	circPTK2 	hsa_circ_PTK2	PTK2	bladder cancer	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circPTK2 promotes bladder cancer cell proliferation, invasion, and cell cycle progression, while its knockdown suppresses these malignant phenotypes and promotes apoptosis. The study suggests that circPTK2 acts as a miRNA sponge for mir129-5p, supporting a ceRNA-type regulatory mechanism in bladder cancer."	0.4236
40658016	DNA and cell biology	2025	Exosome-Mediated circRNA Hsa_Circ_0113050 Enhances Colorectal Cancer Cell Malignancy by Interacting with EIF4A3.	hsa_circ_0113050		hsa_circ_EIF3I	EIF3I	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"This study identifies hsa_circ_0113050 as an up-regulated exosomal circRNA in colorectal cancer tissues and CRC-derived exosomes. EIF4A3 promotes hsa_circ_0113050 biogenesis through interaction with its linear precursor/host gene transcript EIF3I, and exosome-mediated hsa_circ_0113050 enhances CRC cell proliferation, migration, invasion, and tumor growth. Its high expression is associated with advanced clinicopathological features and may represent a therapeutic target or noninvasive biomarker candidate."	0.7785
40659239	Experimental cell research	2025	Hsa_circ_0001640 inactivation of the PI3K/AKT signaling pathway by targeting the MiR-942-5p/PTEN axis to inhibit the progression of non-small cell lung cancer.	hsa_circ_0001640		hsa_circ_EPB41L2	EPB41L2	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; ISH; Microarray	"hsa_circ_0001640 is down-regulated in NSCLC tissues and cell lines and functions as a tumor suppressor. It sponges miR-942-5p to regulate PTEN and inhibit PI3K/AKT signaling, thereby suppressing proliferation, migration, invasion and tumor growth while promoting apoptosis. Higher expression is associated with smaller tumor size and longer survival, suggesting biomarker and therapeutic-target potential."	0.8635
40659295	Fish & shellfish immunology	2025	Circular RNA identification and implication of a role of circAGO3 in the infection of white spot syndrome virus in Pacific white shrimp.		circAGO3	lva_circ_AGO3	LvAGO3	white spot syndrome 	MONDO:0005583	non-human animal disease	up-regulated	RT-qPCR; RNA-seq	"circAGO3 is significantly up-regulated in the gills of WSSV-infected L. vannamei. Functional knockdown experiments showed that circAGO3 supports shrimp defense during WSSV infection, likely through a circAGO3/NW_020872560.1_5514/mRNA network regulating immune- and metabolism-related genes."	0.5761
40659295	Fish & shellfish immunology	2025	Circular RNA identification and implication of a role of circAGO3 in the infection of white spot syndrome virus in Pacific white shrimp.		circMAST3	lva_circ_MAST3	LvMAST3	white spot syndrome 	MONDO:0005583	non-human animal disease	up-regulated	RT-qPCR; RNA-seq	"circMAST3 was identified as a candidate differentially expressed circRNA in L. vannamei gills and was validated by PCR/RNase R/Sanger sequencing. Its expression was significantly up-regulated at 48 h after WSSV infection, but no specific mechanistic or functional experiments were reported for this circRNA."	0.5761
40659295	Fish & shellfish immunology	2025	Circular RNA identification and implication of a role of circAGO3 in the infection of white spot syndrome virus in Pacific white shrimp.		circADAP1	lva_circ_ADAP1	LvADAP1	white spot syndrome 	MONDO:0005583	non-human animal disease	up-regulated	RT-qPCR; RNA-seq	"circADAP1 was identified as a candidate differentially expressed circRNA in L. vannamei gills and was validated by PCR/RNase R/Sanger sequencing. Its expression was significantly up-regulated at 48 h after WSSV infection, but no specific mechanistic or functional experiments were reported for this circRNA."	0.5761
40667845	Epigenomics	2025	The novel ferroptosis-inducing molecule can inhibit the progression of BC by regulating the ubiquitination of UHRF1.	hsa_circ_0005746	circPPP6R1	hsa_circ_PPP6R1	PPP6R1	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR	"circPPP6R1 is downregulated in bladder cancer and functions as a tumor-suppressive circRNA. It inhibits proliferation, migration, invasion, tumor growth, and metastasis by promoting ferroptosis through direct binding to UHRF1 and facilitating UHRF1 ubiquitin-mediated degradation. Higher circPPP6R1 expression is associated with better DFS and OS, supporting its potential as a biomarker and therapeutic target."	0.8736
40669250	International immunopharmacology	2025	Downregulation hsa_circ_0000571 inhibited the malignant progression of NSCLCs by regulation miR-654-5p/S100A11 axis.	hsa_circ_0000571	hsa_-circ_0000571 	hsa_circ_CDC42BPB	CDC42BPB	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"hsa_circ_0000571/circ-0000571 is up-regulated in NSCLC tissues and cell lines and is associated with higher tumor grade, TNM/pathological grade, and poor overall survival. Functionally, circ-0000571 promotes NSCLC proliferation, tumor growth, migration, invasion and pulmonary metastasis. Mechanistically, it acts through the miR-654-5p/S100A11 axis, consistent with a ceRNA-like regulatory model."	0.8156
40680813	Cancer letters	2025	CircRHOBTB3 suppresses MAOA by promoting cytoplasmic retention of NONO to inhibit prostate cancer proliferation and metastasis.	hsa_circ_0007444	circRHOBTB3	hsa_circ_RHOBTB3	RHOBTB3	prostate cancer 	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; ISH; RNA-seq	"circRHOBTB3 is a human RHOBTB3-derived circRNA that is downregulated in prostate cancer and more strongly reduced in metastatic PCa. It suppresses PCa proliferation, migration, invasion, and metastasis by binding NONO, retaining NONO in the cytoplasm, and thereby reducing NONO-mediated MAOA transcription. Clinically, low circRHOBTB3 expression is associated with higher pathological T stage, clinical M stage, and D'Amico grade, suggesting biomarker potential for metastatic PCa."	0.8601
40682984	International immunopharmacology	2025	Mmu_circ_0005698/hsa_circ_0085381/miR-532-3p/Arhgdib axis mediates the ischemic progression of acute kidney injury.	mmu_circ_0005698	mmu_-circ_0005698			acute kidney injury 	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR; Microarray	"mmu_circ_0005698 is a mouse circRNA up-regulated after renal ischemia/reperfusion injury. It promotes renal tubular cell apoptosis and ischemic AKI progression by sponging miR-532-3p and increasing Arhgdib expression; knockdown alleviates renal dysfunction, tubular injury, and apoptosis in the I/R mouse model."	0.6174
40682984	International immunopharmacology	2025	Mmu_circ_0005698/hsa_circ_0085381/miR-532-3p/Arhgdib axis mediates the ischemic progression of acute kidney injury.	hsa_circ_0085381	hsa_-circ_0085381			acute kidney injury 	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR	hsa_circ_0085381 is a human homolog of mmu_circ_0005698 and is up-regulated in I/R-treated HK-2 cells and in plasma from post-cardiac arrest AKI patients. It promotes apoptosis through the miR-532-3p/Arhgdib axis and is proposed as a potential diagnostic biomarker and therapeutic candidate for ischemic AKI.	0.5546
40684838	Cancer letters	2025	CircFLNB upregulated by chemotherapy via alternative splicing suppresses the progression of colorectal cancer.		circFLNB 	hsa_circ_FLNB	FLNB	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; ISH; Microarray	"circFLNB is a human FLNB-derived circRNA that is down-regulated in colorectal cancer but induced by chemotherapy. It suppresses CRC proliferation, migration, invasion, and xenograft growth while promoting apoptosis, mainly by sponging miR-3127-3p to upregulate MOB1B and modulate the Hippo pathway. Chemotherapy promotes circFLNB biogenesis through QKI- and CELF4-dependent alternative splicing, and higher circFLNB expression is associated with better prognosis."	0.8658
40684838	Cancer letters	2025	CircFLNB upregulated by chemotherapy via alternative splicing suppresses the progression of colorectal cancer.		circSMARCA5	hsa_circ_SMARCA5	SMARCA5	colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	"circSMARCA5 was identified in the authors' circRNA microarray screening as a candidate down-regulated in CRC and up-regulated after chemotherapy. Its lower expression in CRC tumors versus adjacent non-tumorous tissues was validated by RT-PCR, but the article did not further define its mechanism, functional role, or clinical prognostic significance."	0.3588
40685053	International journal of biological macromolecules	2025	"CircEGLN1 alleviates calcium oxalate-induced renal injury via miR-212-5p/STARD7 axis, offering a potential strategy for kidney stone prevention."		circEGLN1	hsa_circ_EGLN1	EGLN1	kidney stone disease 	MONDO:0008171	nephrolithiasis	down-regulated	RT-qPCR; ISH; RNA-seq	"circEGLN1 is a conserved EGLN1-derived circRNA that is down-regulated in COM-injured renal tubular cells and nephrolithiasis renal tissues. It protects against CaOx-induced renal oxidative injury and crystal deposition by acting as a miR-212-5p sponge to enhance STARD7 expression, suggesting therapeutic potential for kidney stone prevention."	0.8705
40685053	International journal of biological macromolecules	2025	"CircEGLN1 alleviates calcium oxalate-induced renal injury via miR-212-5p/STARD7 axis, offering a potential strategy for kidney stone prevention."		circEGLN1	mmu_circ_EGLN1	EGLN1	kidney stone disease 	MONDO:0008171	nephrolithiasis	down-regulated	RT-qPCR; ISH; RNA-seq	"circEGLN1 is a conserved EGLN1-derived circRNA that is down-regulated in COM-injured renal tubular cells and nephrolithiasis renal tissues. It protects against CaOx-induced renal oxidative injury and crystal deposition by acting as a miR-212-5p sponge to enhance STARD7 expression, suggesting therapeutic potential for kidney stone prevention."	0.8705
40696234	Journal of physiology and biochemistry	2025	m6A-modified circCCAR1 promotes malignant proliferation by enhancing KIF5B expression in hepatocellular carcinoma.		circCCAR1	hsa_circ_CCAR1	CCAR1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circCCAR1 is upregulated in HCC cells and promotes malignant proliferation in vitro and in a HCCLM3 xenograft model. Mechanistically, m6A-modified circCCAR1 is exported to the cytoplasm by YTHDC1, acts as a ceRNA for miR-641 to increase KIF5B expression, and binds PTBP1 to stabilize KIF5B mRNA. The study suggests circCCAR1 may be a potential therapeutic target for HCC."	0.8415
40696949	Journal of biochemical and molecular toxicology	2025	CircRNA_26782 Regulates Axonal Growth via Inhibiting the Autophagy Pathway in a Rat Model of Spinal Cord Injury.		circRNA_26782 	rno_circ_Akap6	Akap6	spinal cord injury 	MONDO:0043797	spinal cord injury	down-regulated	RNA-seq	"circRNA_26782 is a rat Akap6-derived circRNA downregulated after spinal cord injury. In primary rat spinal neurons, circ_26782 localizes mainly to the cytoplasm and its knockdown promotes axonal elongation through a ceRNA-related circ_26782/miR-19b-2-5p/Rab1b axis that reduces LC3-II/LC3-I and inhibits autophagy."	0.5229
40696971	Journal of biochemical and molecular toxicology	2025	"Circ_PSD3 Stimulates Cell Proliferation, Migration, Invasion and Epithelial to Mesenchymal Transition (EMT) in Papillary Thyroid Carcinoma via the Regulation of miR-145-5p/miR-338-3p/HMGB3 Axis."		circ_PSD3	hsa_circ_PSD3	PSD3	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circ_PSD3 is up-regulated in papillary thyroid carcinoma tissues and cells and functions as an oncogenic circRNA. It promotes PTC cell proliferation, migration, invasion and EMT by sponging miR-145-5p and miR-338-3p, thereby enhancing HMGB3 expression. Its expression is associated with lymph node metastasis, TNM stage and tumor volume, suggesting potential clinical relevance."	0.7129
40700582	Blood	2025	circFUT8 promotes proplatelet formation by interacting with IGF2BP2 and stabilizing TNS1 mRNA in megakaryocytes.		circFUT8	hsa_circ_FUT8	FUT8	thrombocytopenia 	MONDO:0002049	thrombocytopenia	unknown	RT-qPCR; ISH; RNA-seq	"Human circFUT8 is upregulated during megakaryocyte maturation and is abundant in mature megakaryocytes and platelets. It promotes proplatelet formation by interacting with IGF2BP2 to stabilize TNS1 mRNA in an m6A-dependent manner, thereby supporting actin cytoskeleton organization and extracellular matrix spreading/adhesion."	0.8231
40700582	Blood	2025	circFUT8 promotes proplatelet formation by interacting with IGF2BP2 and stabilizing TNS1 mRNA in megakaryocytes.		circFut8	mmu_circ_Fut8	Fut8	thrombocytopenia 	MONDO:0002049	thrombocytopenia	unknown	RT-qPCR	"Mouse circFut8 is the homolog of human circFUT8 and shows conserved upregulation during megakaryocyte differentiation. Its inhibition reduces proplatelet formation and platelet counts in vivo, while overexpression in transplanted lineage-negative cells improves platelet recovery, indicating a functional role in thrombopoiesis."	0.568
40701334	Microbes and infection	2025	Porphyromonas gingivalis-induced HuR upregulation suppresses SLC39A10-derived hsa_circ_0057552 in esophageal squamous cell carcinoma.	hsa_circ_0057552		hsa_circ_SLC39A10	SLC39A10	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	RT-qPCR	"hsa_circ_0057552 is a SLC39A10-derived human circRNA that is downregulated in P. gingivalis-infected ESCC tissues and cells. It suppresses ESCC proliferation, migration, invasion, and tumor growth, partly by competitively binding HuR and reducing HuR-mediated stabilization of SLC39A10 mRNA. The study proposes the P. gingivalis-HuR-hsa_circ_0057552/SLC39A10 regulatory network as a therapeutic target in P. gingivalis-related ESCC."	0.7591
40712910	Experimental cell research	2025	Hsa_circ_0081111 promotes the proliferation and metastasis of non-small cell lung cancer by regulating IGF2BP2-mediated stability of Slug mRNA.	hsa_circ_0081111	circ-COL1A2 	hsa_circ_COL1A2	COL1A2	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"Hsa_circ_0081111 is up-regulated in NSCLC tissues and cell lines and is associated with advanced TNM stage and lymph node metastasis. Functionally, it promotes NSCLC cell proliferation, invasion, EMT, and xenograft tumor growth. Mechanistically, cytoplasmic hsa_circ_0081111 binds the RBP IGF2BP2 to enhance Slug mRNA stability and increase Slug expression, suggesting diagnostic and therapeutic potential in NSCLC."	0.8508
40713005	Archives of biochemistry and biophysics	2025	Mycophenolate mofetil inhibits ferroptosis by boosting autophagy to prevent pulmonary fibrosis.		circFOXP1 	hsa_circ_FOXP1	FOXP1	pulmonary fibrosis 	MONDO:0002771	pulmonary fibrosis	up-regulated	RT-qPCR; ISH; RNA-seq	"circFOXP1 is up-regulated in pulmonary fibrosis/IPF and is reduced by MMF treatment. Mechanistically, circFOXP1 interacts with HuR and supports HuR-mediated stabilization of EZH2, STAT1, and FOXK1 mRNAs, thereby suppressing autophagy and favoring ferroptosis and fibrosis. Overexpression of circFOXP1 reverses the anti-fibrotic effects of MMF in cellular and mouse models."	0.7385
40713005	Archives of biochemistry and biophysics	2025	Mycophenolate mofetil inhibits ferroptosis by boosting autophagy to prevent pulmonary fibrosis.		circFOXP1 	 mmu_circ_FOXP1	FOXP1	pulmonary fibrosis 	MONDO:0002771	pulmonary fibrosis	up-regulated	RT-qPCR; ISH; RNA-seq	"circFOXP1 is up-regulated in pulmonary fibrosis/IPF and is reduced by MMF treatment. Mechanistically, circFOXP1 interacts with HuR and supports HuR-mediated stabilization of EZH2, STAT1, and FOXK1 mRNAs, thereby suppressing autophagy and favoring ferroptosis and fibrosis. Overexpression of circFOXP1 reverses the anti-fibrotic effects of MMF in cellular and mouse models."	0.7385
40715934	Endocrine	2025	The oncogenic role of the circ_0003997/miR-370-3p/HMGA2 axis in papillary thyroid cancer.	hsa_circ_0003997	circ_0003997 	hsa_circ_CLMP	CLMP	papillary thyroid cancer 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0003997/circCLMP is a CLMP-derived circRNA upregulated in PTC tissues and cells. It promotes proliferation, migration, invasion, EMT, and xenograft tumor growth by acting as a cytoplasmic sponge for miR-370-3p and increasing HMGA2 expression. The study proposes the circ_0003997/miR-370-3p/HMGA2 axis as a potential biomarker and therapeutic target in PTC."	0.8396
40719479	IUBMB life	2025	CircROBO2 Orchestrates Osimertinib Resistance Through miR-625-5p/PDGFB-Mediated MAPK Activation in Non-Small Cell Lung Cancer.	hsa_circ_0066556	circROBO2	hsa_circ_ROBO2	ROBO2	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"circROBO2 (hsa_circ_0066556), derived from ROBO2, is up-regulated in osimertinib-resistant NSCLC cells. It promotes osimertinib resistance by sponging miR-625-5p, increasing PDGFB expression, and activating the MAPK/RAF/MEK/ERK pathway, thereby enhancing survival, proliferation, and invasion while reducing apoptosis. The study proposes circROBO2 as a potential biomarker and therapeutic target for osimertinib resistance in NSCLC."	0.7961
40730084	Theriogenology	2025	Porcine reproductive and respiratory syndrome virus downregulates the circ-107191/miR-34c/RAD54L axis to promote testicular cell apoptosis via impaired homologous recombination repair.		circ-107191			PRRSV-induced testicular dysfunction 	MONDO:0002329	testicular disorder	down-regulated	RNA-seq	"PRRSV infection downregulates porcine circ-107191 in testes, resulting in enhanced miR-34c activity and reduced RAD54L expression. This dysregulation impairs homologous recombination repair and promotes testicular apoptosis, oxidative stress, inflammation, BTB disruption, and reduced testosterone production. Restoring circ-107191 expression mitigates tissue damage and is proposed as a therapeutic strategy for PRRSV-induced male reproductive dysfunction."	0.6004
40730119	International immunopharmacology	2025	Circular RNA PVT1 promotes osteoarthritis progression through the miR-550a-3p/CX3CR1 pathway: A mechanistic study.	hsa_circ_0001821	CircPVT1 	hsa_circ_PVT1		osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circPVT1 is upregulated in OA chondrocytes and promotes osteoarthritis progression. Mechanistically, it functions as a ceRNA for miR-550a-3p, thereby relieving repression of CX3CR1 and increasing CX3CR1 expression. Functionally, elevated circPVT1 suppresses chondrocyte proliferation, promotes apoptosis and inflammatory cytokine production, and accelerates extracellular matrix degradation, suggesting biomarker and therapeutic-target potential."	0.6521
40736609	Functional & integrative genomics	2025	CircNOX4 promotes proliferation and resistance by regulating the hsa-miR-6884-5p/YWHAG Axis and ERK signaling pathway in cholangiocarcinoma.	hsa_circ_0023988	circ-NOX4 	hsa_circ_NOX4	NOX4	intrahepatic cholangiocarcinoma 	MONDO:0003210	intrahepatic cholangiocarcinoma	up-regulated	RT-qPCR	"circNOX4 is an upregulated circRNA in ICC derived from the NOX4 gene and is associated with aggressive clinicopathological features and poor survival. It promotes ICC proliferation and tumor growth while inhibiting apoptosis by sponging hsa-miR-6884-5p to increase YWHAG, which interacts with RAF1 and activates RAF/MEK/ERK signaling. circNOX4 also reduces Trametinib sensitivity, supporting its potential as a diagnostic/prognostic biomarker and therapeutic target."	0.8999
40739999	Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology	2025	Hsa_circ_0020491 promotes polycystic ovary syndrome by interacting with IGF2BP2 through regulation of granular cell autophagy and mitochondrial dysfunction.	hsa_circ_0020491	circ_0020491 	hsa_circ_MKI67	MKI67	polycystic ovary syndrome 	MONDO:0008487	polycystic ovary syndrome	up-regulated	RT-qPCR; Microarray	"hsa_circ_0020491 is upregulated in granulosa cells from PCOS patients, DHT-treated KGN cells, and PCOS mouse ovarian tissues. It promotes PCOS progression by interacting with the RBP IGF2BP2, thereby facilitating excessive autophagy and mitochondrial dysfunction; knockdown of circ_0020491 alleviates these pathological changes in vitro and in vivo."	0.8539
40742571	Journal of molecular histology	2025	CircZNF418 alleviates oxidative stress-induced cartilage endplate degeneration by stabilizing Sox9 through HuR.		circZNF418 	hsa_circ_ZNF418	ZNF418	intervertebral disc degeneration 	MONDO:0011385	intervertebral disk degenerative disorder	down-regulated	RT-qPCR	"circZNF418 is down-regulated in degenerative human CEP cells and in oxidative stress-treated CEP cells. Its overexpression protects CEP cells by promoting proliferation, preserving ECM-related collagen II and aggrecan, reducing MMP3 and MMP13, and stabilizing Sox9 through HuR interaction, suggesting therapeutic potential for IDD."	0.6521
40750918	Pediatric research	2025	circANKRD12/circTIMMDC1 synergistically regulates enteric neural crest cell migration via miR-181b-5p-PROX1-NOTCH1 axis in Hirschsprung's disease.	hsa_circ_0003865	circANKRD12 	hsa_circ_ANKRD12	ANKRD12	Hirschsprung's disease 	MONDO:0018309	Hirschsprung disease	down-regulated	RT-qPCR	"circANKRD12 is downregulated in HSCR patient tissues. It promotes neural cell and ENCC migration and proliferation by sponging miR-181b-5p and modulating the PROX1-NOTCH1-HES1 axis, suggesting a potential therapeutic role in HSCR."	0.7519
40750918	Pediatric research	2025	circANKRD12/circTIMMDC1 synergistically regulates enteric neural crest cell migration via miR-181b-5p-PROX1-NOTCH1 axis in Hirschsprung's disease.	hsa_circ_0006884	circTIMMDC1 	hsa_circ_TIMMDC1	TIMMDC1	Hirschsprung's disease 	MONDO:0018309	Hirschsprung disease	down-regulated	RT-qPCR	"circTIMMDC1 is downregulated in HSCR patient tissues. It promotes neural cell and ENCC migration and proliferation by sponging miR-181b-5p and modulating the PROX1-NOTCH1-HES1 axis, acting synergistically with circANKRD12 and suggesting potential therapeutic relevance in HSCR."	0.7519
40754102	Life sciences	2025	"CircRHBDD1(4,5)/CCL2 mRNA interaction promotes breast cancer bone metastasis via bone metastatic niche formation."	hsa_circ_0058493	"circRHBDD1(4,5)"	hsa_circ_RHBDD1	RHBDD1	breast cancer bone metastasis 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circRHBDD1(4,5), also reported as hsa_circ_0058493, is upregulated in bone-tropic metastatic breast cancer cells and bone-metastatic breast cancer tissues. It promotes osteoclastogenesis, bone-metastatic niche formation, and breast cancer bone metastasis by directly binding CCL2 mRNA and recruiting ELAVL1 to enhance CCL2 mRNA stability and translation. High circRHBDD1(4,5) expression is associated with shorter bone-metastasis-free survival, and blocking the circRHBDD1(4,5)-CCL2 mRNA interaction suppresses osteoclastogenesis and bone metastasis in experimental models."	0.8786
40754803	Biomarkers in medicine	2025	Plasma-derived circALG8 and circCAMTA1 as a panel for early diagnosis of non-small cell lung cancer.	hsa_circ_0003615	circALG8	hsa_circ_ALG8	ALG8	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	"circALG8 is a human ALG8-derived circular RNA that is downregulated in NSCLC tumor tissues and plasma. The study validates its circular stability and supports its use as a noninvasive diagnostic biomarker, particularly as part of a plasma circALG8/circCAMTA1 panel for early-stage NSCLC."	0.6676
40754803	Biomarkers in medicine	2025	Plasma-derived circALG8 and circCAMTA1 as a panel for early diagnosis of non-small cell lung cancer.	hsa_circ_0008737	circCAMTA1	hsa_circ_CAMTA1	CAMTA1	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	"circCAMTA1 is a human CAMTA1-derived circular RNA that is downregulated in NSCLC tumor tissues and plasma. The study validates its circular stability and supports its use as a noninvasive diagnostic biomarker, particularly as part of a plasma circALG8/circCAMTA1 panel for early-stage NSCLC."	0.6676
40760232	In vitro cellular & developmental biology. Animal	2025	KHDRBS3-mediated upregulation of circ_0024107 in gastric cancer cells and GC-MSCs synergistically drives gastric cancer cell migration and invasion.	hsa_circ_0024107	circ_0024107 			gastric cancer	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"This study shows that hsa_circ_0024107/circ_0024107 is upregulated in gastric cancer cells and promotes migration and invasion, but not proliferation. GC-MSCs further induce circ_0024107 expression in gastric cancer cells to enhance these pro-migratory and pro-invasive effects. KHDRBS3 is identified as an upstream RBP regulator that increases circ_0024107 levels in both gastric cancer cells and GC-MSCs, forming a KHDRBS3-circ_0024107 axis with potential therapeutic relevance."	0.4546
40763477	International immunopharmacology	2025	miR146a/circKMT2c regulates inflammation in fracture-induced acute lung injury via p65 nuclear translocation.		circKMT2c	rno_circ_KMT2c	KMT2c	fracture-induced acute lung injury 	MONDO:0015796	acute lung injury	down-regulated	RT-qPCR	"In fracture-induced acute lung injury, circKMT2c is significantly downregulated in lung tissue. The study supports a miR146a/circKMT2c/NF-kappaB p65 mechanism in which elevated miR146a suppresses circKMT2c, promoting p65 nuclear translocation and inflammatory cytokine release; restoring circKMT2c activity is suggested to attenuate ALI."	0.5627
40767364	IUBMB life	2025	CircZNF418 Prevents Intervertebral Disc Degeneration by Targeting the HuR/SIRT6 Axis to Protect Against Oxidative Stress-Induced Ferroptosis and Senescence.	hsa_circ_0052318	CircZNF418 	hsa_circ_ZNF418	ZNF418	Intervertebral disc degeneration 	MONDO:0011385	intervertebral disk degenerative disorder	down-regulated	RT-qPCR	"circZNF418 is downregulated in degenerative nucleus pulposus tissues and TBHP-treated nucleus pulposus cells. Functionally, circZNF418 overexpression protects against oxidative stress-induced ferroptosis and cellular senescence, whereas circZNF418 knockdown aggravates these processes. Mechanistically, circZNF418 interacts with HuR and promotes SIRT6 expression, supporting a circZNF418/HuR/SIRT6 axis with potential diagnostic and therapeutic relevance in IVDD."	0.743
40767994	Biochemical genetics	2025	Hsa_circ_0013729 Promotes Gastric Cancer Progression by Regulating MEF2D in ceRNA- and RBP- Dependent Manners.	hsa_circ_0013729	hsa_circ-MAN1A2_001	hsa_circ_MAN1A2	MAN1A2	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"Hsa_circ_0013729 is upregulated in gastric cancer tissues and cell lines and is associated with diagnostic performance and poor overall survival. Functionally, it promotes gastric cancer cell proliferation, migration, and invasion. Mechanistically, it regulates MEF2D through both a miR-361-3p-dependent ceRNA axis and an HNRNPUL1-dependent RBP/mRNA-stabilization mechanism."	0.8197
40776628	"Cell cycle (Georgetown, Tex.)"	2025	METTL3-mediated circ_0003998 serves as oncogene in non-small cell lung cancer through regulating miR-330-5p/CXCL3 axis.	hsa_circ_0003998	circ_0003998	hsa_circ_ARFGEF2	ARFGEF2	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0003998 is up-regulated in NSCLC tissues and cells and functions as an oncogenic circRNA. METTL3 increases circ_0003998 expression through m6A modification, and circ_0003998 promotes NSCLC growth, angiogenesis, migration, invasion and tumorigenesis through the miR-330-5p/CXCL3 axis."	0.7946
40782251	Journal of molecular histology	2025	hsa_circ_0099682 exacerbates the development of diabetic retinopathy by promoting pathological neoangiogenesis via the miR-125b-5p/HNRNPU axis.	hsa_circ_0099682	hsa_ circ_0099682 	hsa_circ_ANKS1B	ANKS1B	diabetic retinopathy 	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR	"hsa_circ_0099682 is a pro-pathogenic circRNA in diabetic retinopathy models. It acts as a cytoplasmic ceRNA that sponges miR-125b-5p, derepresses HNRNPU, and promotes mitochondrial dysfunction, inflammation, oxidative stress, apoptosis, and pathological neoangiogenesis. Silencing hsa_circ_0099682 protects HG-injured HRMECs and improves retinal pathology in STZ-induced DR rats."	0.7924
40789279	Current eye research	2025	Transcriptome Sequencing Reveals ceRNA Networks and Molecular Signatures in Myopic Mouse Retina.		novel_circ_0001750			myopia 	MONDO:0001384	myopia	up-regulated	RT-qPCR; RNA-seq	"novel_circ_0001750 was identified as an up-regulated circRNA in the retina of form-deprivation myopia mice and was validated by qRT-PCR. The study proposes that novel_circ_0001750 participates in myopia regulation through a ceRNA axis involving mmu-miR-212-5p and Sstr3, with SSTR3 protein expression also increased in myopic retina."	0.6432
40794014	Molecular carcinogenesis	2025	CircLPP Activates the Wnt/beta-Catenin Signaling Pathway via the miR-665/Wnt3a Axis and Promotes Proliferation and Metastasis in Colorectal Cancer.	hsa_circ_0003759	circLPP 	hsa_circ_LPP	LPP	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"circLPP/hsa_circ_0003759 is upregulated in colorectal cancer tissues and cell lines and is associated with aggressive clinicopathological characteristics and shorter overall survival. Functionally, it promotes CRC proliferation, migration, invasion, tumor growth, and metastasis. Mechanistically, circLPP acts as a miR-665 sponge to derepress Wnt3a and activate Wnt/beta-catenin signaling."	0.8459
40796177	Toxicological sciences : an official journal of the Society of Toxicology	2025	"Circular RNA hsa_circ_0099188 regulates inducible nitric oxide synthase and chemokine transcription in macrophages by targeting the hsa-miR-381-3p/PPP3CA and hsa-miR-381-3p/KLF4 pathways in response to 4,4'-methylene diphenyl diisocyanate-glutathione conjugate exposure."	hsa_circ_0099188		hsa_circ_TRHDE	TRHDE	occupational asthma 	MONDO:0022742	occupational asthma	up-regulated	RT-qPCR	"This study identifies hsa_circ_0099188 as an MDI-GSH-inducible circRNA in human THP-1 macrophages. It binds/sponges hsa-miR-381-3p and regulates PPP3CA/NOS2 and KLF4-dependent M2 macrophage chemokine pathways, thereby promoting chemokine secretion and T-cell/eosinophil chemotaxis relevant to MDI-induced occupational asthma pathogenesis."	0.6812
40810915	Biochemical genetics	2025	CircRNA_0001412 and CircRNA_0001566 as Potential Biomarkers for the Diagnosis of Rheumatoid Arthritis.		CircRNA_0001412 	hsa_circ_FIP1L1	FIP1L1	Rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; RNA-seq	"CircRNA_0001412 was identified as significantly upregulated in PBMCs from RA patients and validated by RT-qPCR in a clinical cohort. It has diagnostic biomarker potential, correlates with CRP as an indicator of inflammatory activity, and is predicted to contribute to RA pathogenesis through miRNA-related regulation of PI3K-Akt-mediated T-cell activation."	0.559
40810915	Biochemical genetics	2025	CircRNA_0001412 and CircRNA_0001566 as Potential Biomarkers for the Diagnosis of Rheumatoid Arthritis.		CircRNA_0001566 	hsa_circ_MAPK9	MAPK9	Rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; RNA-seq	"CircRNA_0001566 was identified as significantly upregulated in PBMCs from RA patients and validated by RT-qPCR in a clinical cohort. It showed diagnostic biomarker potential for RA, while bioinformatics analyses predicted that it may contribute to RA pathogenesis through miRNA-related regulation of PI3K-Akt-mediated T-cell activation and processes related to cell proliferation and cell cycle regulation."	0.559
40811419	IEEE transactions on computational biology and bioinformatics	2025	CircRNA Profiles Analysis of Neuroblastoma for Identification of Drug Targets.	hsa_circ_0051680				neuroblastoma 	MONDO:0005072	neuroblastoma	dysregulated	RNA-seq	"hsa_circ_0051680 was identified as a dysregulated hub circRNA in neuroblastoma by integrative circRNA-seq analysis. The study predicts that it interacts with the RBP FUS and may contribute to neuroblastoma pathogenesis, making it a potential diagnostic biomarker."	0.2414
40811419	IEEE transactions on computational biology and bioinformatics	2025	CircRNA Profiles Analysis of Neuroblastoma for Identification of Drug Targets.	hsa_circ_0006107				neuroblastoma 	MONDO:0005072	neuroblastoma	dysregulated	RNA-seq	"hsa_circ_0006107 was identified as a dysregulated hub circRNA in neuroblastoma. It is predicted to interact with IGF2BP1 and is linked to osimertinib response information, suggesting potential relevance to neuroblastoma progression and drug resistance targeting."	0.2414
40811419	IEEE transactions on computational biology and bioinformatics	2025	CircRNA Profiles Analysis of Neuroblastoma for Identification of Drug Targets.	hsa_circ_0000786				neuroblastoma 	MONDO:0005072	neuroblastoma	dysregulated	RNA-seq	"hsa_circ_0000786 was identified as a dysregulated hub circRNA in neuroblastoma and predicted to encode a protein with a DAGKc domain. Molecular docking predicted a high-affinity interaction between this circRNA-derived protein and S05471, supporting its proposed role as a candidate drug target."	0.2414
40811419	IEEE transactions on computational biology and bioinformatics	2025	CircRNA Profiles Analysis of Neuroblastoma for Identification of Drug Targets.	hsa_circ_0005087				neuroblastoma 	MONDO:0005072	neuroblastoma	dysregulated	RNA-seq	"hsa_circ_0005087 was identified as a dysregulated hub circRNA in neuroblastoma and predicted to encode a protein with a CS domain. Docking analysis predicted interaction between the encoded protein and KM09073, supporting its potential as a neuroblastoma drug target."	0.2414
40811419	IEEE transactions on computational biology and bioinformatics	2025	CircRNA Profiles Analysis of Neuroblastoma for Identification of Drug Targets.	hsa_circ_0006867				neuroblastoma 	MONDO:0005072	neuroblastoma	up-regulated	RNA-seq	"hsa_circ_0006867 is reported as upregulated in neuroblastoma. The study predicts that it may influence neuroblastoma through a circRNA-derived protein containing BEACH domains, and docking analysis identifies high-affinity small-molecule complexes, supporting its candidacy as a drug target."	0.2414
40811419	IEEE transactions on computational biology and bioinformatics	2025	CircRNA Profiles Analysis of Neuroblastoma for Identification of Drug Targets.	hsa_circ_0001238				neuroblastoma 	MONDO:0005072	neuroblastoma	dysregulated	RNA-seq	hsa_circ_0001238 was identified among hub circRNAs and predicted to encode a unique peptide with membrane-associated and coiled-coil features. The article suggests that domain features of such circRNA-encoded proteins may be relevant to neuroblastoma development.	0.2414
40811419	IEEE transactions on computational biology and bioinformatics	2025	CircRNA Profiles Analysis of Neuroblastoma for Identification of Drug Targets.	hsa_circ_0001079				neuroblastoma 	MONDO:0005072	neuroblastoma	dysregulated	RNA-seq	hsa_circ_0001079 was identified as a hub circRNA and predicted to encode a peptide with a protein kinase domain. The authors suggest this domain may influence proliferation and differentiation of neuroblastoma cells and may have therapeutic relevance.	0.2414
40811419	IEEE transactions on computational biology and bioinformatics	2025	CircRNA Profiles Analysis of Neuroblastoma for Identification of Drug Targets.	hsa_circ_0032876				neuroblastoma 	MONDO:0005072	neuroblastoma	dysregulated	RNA-seq	"hsa_circ_0032876 was identified among hub circRNAs and predicted to encode a 306-amino-acid protein containing WD-40 repeats. This domain annotation suggests possible involvement in cellular processes such as signaling, cell cycle control and apoptosis in neuroblastoma-related biology."	0.2414
40811419	IEEE transactions on computational biology and bioinformatics	2025	CircRNA Profiles Analysis of Neuroblastoma for Identification of Drug Targets.		hsa_circ_000396			neuroblastoma 	MONDO:0005072	neuroblastoma	up-regulated	RNA-seq	"hsa_circ_000396 was described as upregulated in neuroblastoma among the study's hub circRNAs. The paper does not provide a neuroblastoma-specific mechanistic validation for this circRNA, but discusses its disease-dependent expression patterns as relevant to therapeutic target consideration."	0.2414
40818763	Experimental cell research	2025	CALD1-derived circ-0003746 targeting miR-526b promotes EMT-mediated bladder cancer progression.	hsa_circ_0003746	circ-0003746	hsa_circ_CALD1	CALD1	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circ-0003746 is a CALD1-derived circRNA up-regulated in bladder cancer tissues and cell lines. It promotes BCa proliferation, migration, invasion, tumor growth and metastasis by sponging miR-526b and activating EMT-related changes. The study suggests circ-0003746 may be a biomarker and therapeutic target for BCa."	0.8326
40827042	Biotechnology and bioengineering	2025	3D hESC Exosome-Derived Circular RNA hsa_circ_0076798 Inhibits M1 Macrophage Inflammatory Response and Alleviates Liver Fibrosis by Suppressing TNF/NF-kappaB Pathway Through miR-1184/DICER1 Axis.	hsa_circ_0076798	hsa_-circ_0076798	hsa_circ_GCLC	GCLC	liver fibrosis 	MONDO:0100430	fibrotic liver disease	down-regulated	RT-qPCR; Microarray	"hsa_circ_0076798 is a human 3D hESC exosome-enriched circRNA that is reduced in liver fibrosis tissues. It acts as a sponge for miR-1184, increases DICER1 expression, suppresses TNF/NF-kappaB signaling, and reduces M1 macrophage inflammation while promoting anti-inflammatory macrophage features, thereby contributing to alleviation of liver fibrosis."	0.7893
40840404	Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy	2025	Targeting CLK1/SRSF7 axis-dependent alternative splicing sensitizes pancreatic ductal adenocarcinoma to chemotherapy and immunotherapy.	hsa_circ_0007767	cALG8 	hsa_circ_ALG8	ALG8	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"This study identifies hsa_circ_0007767/cALG8 as a highly up-regulated circRNA in gemcitabine-resistant PDAC cells and patient tumors. Nuclear cALG8 functions as a scaffold for the CLK1/SRSF7 splicing complex, promoting SRSF7 phosphorylation, ATM-203 splicing, DNA damage repair, chemoresistance, and immune suppression; ASO-mediated cALG8 targeting reverses resistance and enhances anti-tumor immunity."	0.904
40840702	Neuroscience	2025	CircFGFR2 induces astrocyte pyroptosis to promote ischemic stroke.		circFGFR2	hsa_circ_FGFR2	FGFR2	ischemic stroke 	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; ISH; RNA-seq	"circFGFR2 was identified as an up-regulated pyroptosis-associated circRNA in a human cerebral organoid ischemic stroke model and in OGD/R-induced human astrocytes. Functional knockdown experiments showed that circFGFR2 promotes astrocytic pyroptosis and inflammatory cytokine release, supporting its role as a potential molecular contributor to ischemic stroke pathogenesis."	0.5229
40844647	"Medical oncology (Northwood, London, England)"	2025	"Circ_0000847 promotes the migration, invasion, and EMT process in colorectal cancer through binding to IGF2BP2 to enhance IGF2 mRNA stability."	hsa_circ_0000847	circ_0000847	hsa_circ_SMAD2	SMAD2	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; Microarray	"hsa_circ_0000847 is up-regulated in colorectal cancer and acts as an oncogenic circRNA. It promotes CRC cell viability, migration, invasion, EMT, and xenograft tumor growth by binding IGF2BP2 and stabilizing IGF2 mRNA, suggesting potential therapeutic relevance."	0.8237
40846135	Fish & shellfish immunology	2025	circRNA-miRNA interactions regulate the immune response by activating the NF-kappaB pathway through targeting IkappaBalpha in Sebastes schlegelii.		circRNA-4254 			Edwardsiella piscicida infection	MONDO:1014977		down-regulated	RT-qPCR; RNA-seq	"circRNA-4254 is downregulated after pathogen infection or immune stimulation in S. schlegelii. It functions as a ceRNA for miRNA-286, relieves repression of IkappaBalpha1, modulates NF-kappaB pathway-related inflammatory gene expression, and participates in innate antibacterial immune responses."	0.6868
40846135	Fish & shellfish immunology	2025	circRNA-miRNA interactions regulate the immune response by activating the NF-kappaB pathway through targeting IkappaBalpha in Sebastes schlegelii.		circRNA-273			Edwardsiella piscicida infection	MONDO:1014977		down-regulated	RT-qPCR; RNA-seq	"circRNA-273 is downregulated after pathogen infection or immune stimulation in S. schlegelii. It functions as a ceRNA for miRNA-786, relieves repression of IkappaBalpha2, modulates NF-kappaB pathway-related inflammatory gene expression, and participates in innate antibacterial immune responses."	0.6868
40846135	Fish & shellfish immunology	2025	circRNA-miRNA interactions regulate the immune response by activating the NF-kappaB pathway through targeting IkappaBalpha in Sebastes schlegelii.		circRNA-4254 			Streptococcus iniae infection	MONDO:0005114	pneumococcal infection	down-regulated	RT-qPCR; RNA-seq	"circRNA-4254 is downregulated after pathogen infection or immune stimulation in S. schlegelii. It functions as a ceRNA for miRNA-286, relieves repression of IkappaBalpha1, modulates NF-kappaB pathway-related inflammatory gene expression, and participates in innate antibacterial immune responses."	0.6868
40846135	Fish & shellfish immunology	2025	circRNA-miRNA interactions regulate the immune response by activating the NF-kappaB pathway through targeting IkappaBalpha in Sebastes schlegelii.		circRNA-273			Streptococcus iniae infection	MONDO:0005114	pneumococcal infection	down-regulated	RT-qPCR; RNA-seq	"circRNA-273 is downregulated after pathogen infection or immune stimulation in S. schlegelii. It functions as a ceRNA for miRNA-786, relieves repression of IkappaBalpha2, modulates NF-kappaB pathway-related inflammatory gene expression, and participates in innate antibacterial immune responses."	0.6868
40850182	Biochemical and biophysical research communications	2025	circFOXK2 inhibits vascular permeability and angiogenesis in advanced lung adenocarcinoma via the miR-1275/CLDN1 axis.	hsa_circ_0000817	circ-FOXK2 	hsa_circ_FOXK2	FOXK2	advanced lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; ISH; Microarray	"circFOXK2 is down-regulated in advanced LUAD tissues, especially in highly angiogenic tumors, and low expression is associated with poor prognosis. Mechanistically, reduced circFOXK2 increases miR-1275, which is transferred via exosomes to endothelial cells and suppresses CLDN1, thereby enhancing vascular permeability and angiogenesis. circFOXK2 overexpression also synergizes with bevacizumab to inhibit angiogenesis and tumor growth, suggesting therapeutic potential."	0.8645
40850203	International immunopharmacology	2025	CircMTND5 participates in tubulointerstitial injury in lupus nephritis by binding with A1CF protein.		CircRNA MTND5 	hsa_circ_MTND5	MTND5	lupus nephritis 	MONDO:0005556	lupus nephritis	down-regulated	RT-qPCR; ISH	"circMTND5 is down-regulated in kidney tissues in lupus nephritis and appears to protect against renal tubulointerstitial fibrosis. Mechanistically, circMTND5 binds the RNA-binding protein A1CF, thereby regulating E-cadherin and profibrotic proteins such as alpha-SMA, TGF-beta and fibronectin; its overexpression reverses hTGF-beta-induced fibrotic changes in HK-2 cells."	0.7325
40856974	Biochemical genetics	2025	Predictive Value of circ_0020850 for Functional Outcomes After Acute Ischemic Stroke in Hospitalized Convalescent Patients.	hsa_circ_0020850	circ_0020850			acute ischemic stroke 	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR	"circ_0020850 is up-regulated in the serum of AIS patients and decreases after rehabilitation. Its expression is negatively correlated with MMSE scores and has prognostic value for rehabilitation outcomes. Mechanistically, the study supports an interaction with miR-629 and suggests that the circ_0020850/miR-629 axis may be involved in AIS-related pathways such as Wnt signaling."	0.7156
40858175	International journal of biological macromolecules	2025	Upregulation of has_circ_0008389 promotes esophageal squamous cell carcinoma progression via miR-761 sponging and P2RY2 mRNA stabilization.	hsa_circ_0008389	circ_0008389 	hsa_circ_DNAJC11	DNAJC11	Esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0008389 is up-regulated in ESCC tissues and patient plasma and correlates with aggressive clinicopathological features. It promotes ESCC proliferation, migration, invasion, tumor growth, and metastasis by sponging miR-761, stabilizing P2RY2 mRNA, and activating PI3K/AKT signaling. The study proposes circ_0008389 as an oncogenic driver and potential diagnostic marker for ESCC."	0.872
40878190	Lab on a chip	2025	"Modular RCA-CRISPR/Cas12a amplification on a multi-volume SlipChip for ultrafast, single-copy quantification of circRNA and miRNA in ovarian cancer."	hsa_circ_0049101	circMUC16	hsa_circ_MUC16	MUC16	ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; Microarray	"This study evaluated hsa_circ_0049101/circMUC16 as an ovarian cancer liquid biopsy biomarker rather than as a mechanistic regulator. Its expression was higher in OC cell lines and clinical blood samples, increased with disease stage, correlated strongly with RT-qPCR measurements, and showed high diagnostic performance for both all-stage and early-stage OC."	0.5261
40879806	Metabolic brain disease	2025	Circ_0049472 downregulation relieves Amyloid-beta-induced neuronal injury by modulating PDE4A expression via targeting miR-22-3p in Alzheimer's disease.	hsa_circ_0049472	circ_0049472	hsa_circ_PRKCSH	PRKCSH	Alzheimer's disease 	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR	"circ_0049472 is up-regulated in Abeta-induced AD-like neuronal cell models. Its knockdown alleviates neuronal injury by restoring viability and proliferation and reducing apoptosis, inflammatory cytokine release, and mitochondrial dysfunction. Mechanistically, circ_0049472 functions as a miR-22-3p sponge to increase PDE4A expression through the circ_0049472/miR-22-3p/PDE4A axis."	0.6873
40882807	Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology	2026	Circ_0005372 targets the miR-153-3p/ITGB3 axis to stimulate the PI3K/AKT signaling pathway to facilitate the occurrence and development of congenital heart disease and pulmonary arterial hypertension in children.	hsa_circ_0005372	circ_0005372			congenital heart disease 	MONDO:0005453	congenital heart disease	up-regulated	RT-qPCR	"Circ_0005372 is up-regulated in PAH-CHD neonatal plasma samples and hypoxia-induced HPASMCs. It promotes HPASMC proliferation, migration, and invasion by targeting miR-153-3p, increasing ITGB3, and activating the PI3K/AKT signaling pathway, suggesting potential biomarker value for PAH-CHD."	0.8275
40882807	Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology	2026	Circ_0005372 targets the miR-153-3p/ITGB3 axis to stimulate the PI3K/AKT signaling pathway to facilitate the occurrence and development of congenital heart disease and pulmonary arterial hypertension in children.	hsa_circ_0005372	circ_0005372			pulmonary arterial hypertension	MONDO:0015924	pulmonary arterial hypertension	up-regulated	RT-qPCR	"Circ_0005372 is up-regulated in PAH-CHD neonatal plasma samples and hypoxia-induced HPASMCs. It promotes HPASMC proliferation, migration, and invasion by targeting miR-153-3p, increasing ITGB3, and activating the PI3K/AKT signaling pathway, suggesting potential biomarker value for PAH-CHD."	0.8275
40882876	Biochemical pharmacology	2025	CircCRIM1 promotes the translation of HIF-1alpha protein through its interaction with PTBP3 and enhances malignant progression and angiogenesis in glioblastoma.	hsa_circ_0002346	circ-CRIM1 	hsa_circ_CRIM1	CRIM1	glioblastoma 	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR	"In this study, circCRIM1 is a human CRIM1-derived circRNA upregulated in glioma cells and functions as an oncogenic circRNA in glioblastoma/glioma. It promotes malignant progression and angiogenesis by scaffolding PTBP3 to the HIF-1alpha 5¡äUTR, enhancing HIF-1alpha protein translation and VEGFA expression; EIF4A3 also promotes its circularization under hypoxic conditions."	0.7982
40885481	The American journal of the medical sciences	2026	CircCOL3A1 ameliorates myocardial ischemia-reperfusion injury by regulating miR-29b-3p/MDM2-mediated apoptosis.			hsa_circ_COL3A1	COL3A1	myocardial ischemia-reperfusion injury 	MONDO:0005203	ischemia reperfusion injury	down-regulated	RT-qPCR	"CircCOL3A1 is downregulated in myocardial I/R injury models and cardiomyocyte H/R injury models. Its overexpression protects myocardial tissue and cardiomyocytes by sponging miR-29b-3p, restoring MDM2 expression, improving cell viability, and reducing apoptosis and pyroptosis. The study proposes circCOL3A1 as a potential therapeutic target for myocardial I/R injury."	0.6279
40885481	The American journal of the medical sciences	2026	CircCOL3A1 ameliorates myocardial ischemia-reperfusion injury by regulating miR-29b-3p/MDM2-mediated apoptosis.			mmu_circ_Col3a1	Col3a1	myocardial ischemia-reperfusion injury 	MONDO:0005203	ischemia reperfusion injury	down-regulated	RT-qPCR	"CircCOL3A1 is downregulated in myocardial I/R injury models and cardiomyocyte H/R injury models. Its overexpression protects myocardial tissue and cardiomyocytes by sponging miR-29b-3p, restoring MDM2 expression, improving cell viability, and reducing apoptosis and pyroptosis. The study proposes circCOL3A1 as a potential therapeutic target for myocardial I/R injury."	0.6279
40885481	The American journal of the medical sciences	2026	CircCOL3A1 ameliorates myocardial ischemia-reperfusion injury by regulating miR-29b-3p/MDM2-mediated apoptosis.			rno_circ_Col3a1	Col3a1	myocardial ischemia-reperfusion injury 	MONDO:0005203	ischemia reperfusion injury	down-regulated	RT-qPCR	"CircCOL3A1 is downregulated in myocardial I/R injury models and cardiomyocyte H/R injury models. Its overexpression protects myocardial tissue and cardiomyocytes by sponging miR-29b-3p, restoring MDM2 expression, improving cell viability, and reducing apoptosis and pyroptosis. The study proposes circCOL3A1 as a potential therapeutic target for myocardial I/R injury."	0.6279
40886783	American journal of obstetrics and gynecology	2026	"Circular RNAs accumulate in aging human placental tissue and in stillbirth, leading to DNA damage and cellular senescence."	hsa_circ_0009000	circ_0009000			unexplained stillbirth 	MONDO:0005047	infertility disorder	up-regulated	RT-qPCR	"hsa_circ_0009000 is increased in stillbirth placentae and in maternal blood before stillbirth. The study supports its involvement in placental aging through circRNA:DNA complex formation, contributing to DNA damage and cellular senescence."	0.5129
40886783	American journal of obstetrics and gynecology	2026	"Circular RNAs accumulate in aging human placental tissue and in stillbirth, leading to DNA damage and cellular senescence."	hsa_circ_0024157	circ_0024157			unexplained stillbirth 	MONDO:0005047	infertility disorder	up-regulated	RT-qPCR	hsa_circ_0024157 is increased in stillbirth placentae but was not significantly changed in maternal blood before stillbirth. It is implicated in placental aging through binding to placental DNA and circR-loop formation.	0.5129
40886783	American journal of obstetrics and gynecology	2026	"Circular RNAs accumulate in aging human placental tissue and in stillbirth, leading to DNA damage and cellular senescence."	hsa_circ_0061017	circ_0061017			unexplained stillbirth 	MONDO:0005047	infertility disorder	up-regulated	RT-qPCR	hsa_circ_0061017 is increased in stillbirth placentae but was not significantly changed in maternal blood before stillbirth. The study implicates it in placental aging through binding to placental DNA and circR-loop formation.	0.5129
40886783	American journal of obstetrics and gynecology	2026	"Circular RNAs accumulate in aging human placental tissue and in stillbirth, leading to DNA damage and cellular senescence."	hsa_circ_0036877	circ_0036877			unexplained stillbirth 	MONDO:0005047	infertility disorder	up-regulated	RT-qPCR	hsa_circ_0036877 is increased in stillbirth placentae and in maternal blood before stillbirth. It is implicated in placental aging and stillbirth risk through DNA binding and circR-loop formation.	0.5129
40886783	American journal of obstetrics and gynecology	2026	"Circular RNAs accumulate in aging human placental tissue and in stillbirth, leading to DNA damage and cellular senescence."	hsa_circ_0054624	circ_0054624			unexplained stillbirth 	MONDO:0005047	infertility disorder	up-regulated	RT-qPCR	hsa_circ_0054624 is increased in stillbirth placentae and in maternal blood before stillbirth. It is implicated as a candidate marker of accelerated placental aging and stillbirth risk via DNA binding and circR-loop formation.	0.5129
40886783	American journal of obstetrics and gynecology	2026	"Circular RNAs accumulate in aging human placental tissue and in stillbirth, leading to DNA damage and cellular senescence."	hsa_circ_0111277	circ_0111277 			unexplained stillbirth 	MONDO:0005047	infertility disorder	up-regulated	RT-qPCR	hsa_circ_0111277 is increased in stillbirth placentae and in maternal blood before stillbirth. It is implicated in accelerated placental aging and may contribute to stillbirth risk through circRNA:DNA complex formation.	0.5129
40886783	American journal of obstetrics and gynecology	2026	"Circular RNAs accumulate in aging human placental tissue and in stillbirth, leading to DNA damage and cellular senescence."	hsa_circ_0000284	circ_0000284	hsa_circ_HIPK3	HIPK3	unexplained stillbirth 	MONDO:0005047	infertility disorder	up-regulated	RT-qPCR	"hsa_circ_0000284 is increased in stillbirth placentae and is the mechanistically validated circRNA in this study. It forms circR-loops in primary syncytiotrophoblasts, and its knockdown reduces DNA damage and senescence-associated gene expression, supporting a role in placental aging and stillbirth pathogenesis."	0.5917
40892182	Science China. Life sciences	2026	circSCAP-encoded SCAP-129aa mediates platinum resistance in triple-negative breast cancer via the PI3K/AKT pathway.	hsa_circ_0007291	circSCAP	hsa_circ_SCAP	SCAP	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; RNA-seq	"circSCAP (hsa_circ_0007291) is a human SCAP-derived circular RNA upregulated in platinum-resistant TNBC. It encodes SCAP-129aa, which binds PIK3R2, prevents its ubiquitination-mediated degradation, activates PI3K/AKT signaling, and promotes cisplatin/platinum resistance. Silencing circSCAP re-sensitizes resistant TNBC models to platinum therapy, supporting circSCAP/SCAP-129aa as potential biomarkers and therapeutic targets."	0.8889
40892530	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2025	circHMGCS1 Promotes the Progression of NSCLC by Regulating the HuR/SFPQ/TNF Pathway.	hsa_circ_0072387	circHMGCS1	hsa_circ_HMGCS1	HMGCS1	non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circHMGCS1 (hsa_circ_0072387) is upregulated in NSCLC tissues and cells. It promotes NSCLC proliferation, migration, and xenograft tumor growth by binding HuR, inhibiting HuR ubiquitin-mediated degradation, and enhancing HuR-mediated stabilization of SFPQ mRNA, with downstream involvement of the TNF signaling pathway."	0.8866
40899663	"Chemical communications (Cambridge, England)"	2025	An electrochemical biosensor for breast cancer diagnosis based on RCA-enhanced metal-organic framework self-assembly.			hsa_circ_HER2		breast cancer 	MONDO:0007254	breast cancer	up-regulated	Others	"This study developed an RCA-enhanced MOF-based electrochemical biosensor to sensitively quantify serum circ-HER2. Serum circ-HER2 levels were higher in HER2-positive breast cancer samples than in TNBC samples, supporting its use for breast cancer molecular typing and potential HER2-targeted therapy monitoring."	0.208
40908373	Cell death and differentiation	2026	Chromatin-associated circRNA ciCRLF3(2) regulates cell differentiation blockage via activating non-homologous end joining-based DNA repair.		ciCRLF3(2)	hsa_circ_CRLF3	CRLF3	Mixed-lineage leukemia (MLL)rearranged (MLL-r) leukemia 	MONDO:0850450	mixed phenotype acute leukemia with MLL rearranged	up-regulated	RT-qPCR; RNA-seq	"ciCRLF3(2) is a human chromatin-associated circRNA upregulated in MLL-r leukemia. It acts as a scaffold in the NHEJ complex by binding NF90 and promoting recruitment/interaction of NHEJ regulators, thereby supporting DNA repair, proliferation, differentiation blockade and leukemia progression. High abundance has diagnostic value for MLL-r leukemia and predicts poorer leukemia-free survival."	0.8913
40908373	Cell death and differentiation	2026	Chromatin-associated circRNA ciCRLF3(2) regulates cell differentiation blockage via activating non-homologous end joining-based DNA repair.		IL3RA(NE)	hsa_circ_IL3RA	IL3RA	MLL-rearranged (MLL-r) leukemia 	MONDO:0850450	mixed phenotype acute leukemia with MLL rearranged	unknown	RT-qPCR; RNA-seq	"IL3RA(NE) is a human chromatin-associated circRNA functionally investigated in MLL-r leukemia cells. Its depletion increases DNA damage and produces anti-leukemic phenotypes including reduced proliferation, increased apoptosis, differentiation induction and impaired self-renewal, suggesting an oncogenic role in MLL-r leukemia."	0.6988
40908373	Cell death and differentiation	2026	Chromatin-associated circRNA ciCRLF3(2) regulates cell differentiation blockage via activating non-homologous end joining-based DNA repair.		"circABR(2,15)"	hsa_circ_ABR	ABR	MLL-rearranged (MLL-r) leukemia 	MONDO:0850450	mixed phenotype acute leukemia with MLL rearranged	unknown	RT-qPCR; RNA-seq	"circABR(2,15) is a human chromatin-associated circRNA functionally investigated in MLL-r leukemia cells. Its depletion increases DNA damage and produces anti-leukemic phenotypes including reduced proliferation, increased apoptosis, differentiation induction and impaired self-renewal, suggesting an oncogenic role in MLL-r leukemia."	0.6988
40911155	"Reproductive sciences (Thousand Oaks, Calif.)"	2025	Circ_0070987 Promotes Pyroptosis of Ovarian Granulosa Cells in Polycystic Ovarian Syndrome Through the miR-139-5/CDH1 Axis.	hsa_circ_0070987	circ_0070987			Polycystic ovary syndrome 	MONDO:0008487	polycystic ovary syndrome	up-regulated	RT-qPCR	"This study found that circ_0070987 is up-regulated in DHT-induced PCOS granulosa cell models. Functionally, circ_0070987 promotes ovarian granulosa cell pyroptosis and reduces cell viability, while its knockdown suppresses pyroptosis markers and inflammatory cytokines. Mechanistically, circ_0070987 acts through the miR-139-5p/CDH1 axis, suggesting a potential therapeutic target for PCOS."	0.6908
40913157	Functional & integrative genomics	2025	CircSHPRH inhibits malignancy progression of head and neck squamous cell carcinoma by regulating PI3K/AKT/mTOR signaling pathway.	hsa_circ_0001649	circSHPRH	hsa_circ_SHPRH	SHPRH	head and neck squamous cell carcinoma 	MONDO:0010150	head and neck squamous cell carcinoma	down-regulated	RT-qPCR	"CircSHPRH is a human circRNA derived from SHPRH and is significantly downregulated in HNSCC tissues and cell lines. In this study, circSHPRH overexpression suppressed proliferation, migration, invasion, EMT-related marker changes, and xenograft tumor growth while promoting apoptosis. Mechanistically, circSHPRH acted as a tumor suppressor at least partly by inhibiting PI3K/AKT/mTOR signaling, and higher expression was associated with better overall survival."	0.8169
40915343	Experimental cell research	2025	CircTTC3 regulates the osteogenic differentiation of adipose-derived mesenchymal stem cells via miR-205/Smad3 axis.		circ_000584 	rno_circ_TTC3	TTC3	bone defects 	MONDO:0005381	bone disorder	up-regulated	RT-qPCR; RNA-seq	"circTTC3 is upregulated during osteogenic differentiation of rat ADSCs and promotes osteogenesis and cranial defect repair. Mechanistically, circTTC3 acts as a ceRNA by sponging miR-205, which increases Smad3 expression and enhances osteogenic marker expression and new bone formation."	0.7968
40916530	Nan fang yi ke da xue xue bao = Journal of Southern Medical University	2025	"[Circ_0000437 promotes proliferation, invasion, migration and epithelial-mesenchymal transition of breast cancer cells by targeting the let-7b-5p/CTPS1 axis]."	hsa_circ_0000437	circ_0000437	hsa_circ_CORO1C	CORO1C	breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circ_0000437 is upregulated in breast cancer tissues and cell lines. It promotes proliferation, invasion, migration, EMT and in vivo tumor growth by sponging let-7b-5p and regulating CTPS1, with downstream involvement of the Notch signaling pathway."	0.7795
40921154	"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association"	2025	Role of circ_0002590 in Neuroinflammation Via the miR-1184/NLRP1 Axis in Painful Diabetic Neuropathy.	hsa_circ_0002590	circ_0002590 	hsa_circ_UBE2K	UBE2K	Painful diabetic neuropathy 	MONDO:0006626	diabetic neuropathy	up-regulated	RT-qPCR	"circ_0002590 is upregulated in high glucose-treated human Schwann cells used as an in vitro PDN-related neuroinflammation model. It promotes inflammatory cytokine release and decreases cell viability by acting as a miR-1184 sponge, thereby increasing NLRP1 expression; silencing circ_0002590 exerts anti-inflammatory effects."	0.7363
40921709	Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology	2025	The Function of Hsa_circ_0001862 Regulating miR-23a-IRF1/PPP2R5E Axis to Oral Squamous Cell Carcinoma Development.	hsa_circ_0001862				oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR	"In this study, hsa_circ_0001862 is reported to be downregulated in OSCC/tongue squamous cell carcinoma and to function as a tumor-suppressive circRNA. It binds/sponges miR-23a, thereby relieving miR-23a-mediated repression of the downstream tumor suppressor genes IRF1 and PPP2R5E. Functionally, hsa_circ_0001862 suppresses CAL27 cell proliferation, colony formation, migration and invasion while promoting apoptosis, suggesting potential clinical value in OSCC."	0.6536
40923658	General physiology and biophysics	2025	"circ_0049271 downregulation ameliorates lipopolysaccharide-induced human renal tubular endothelial cell apoptosis, inflammation and oxidative stress."	hsa_circ_0049271	circ_0049271	hsa_circ_KEAP1	KEAP1	sepsis-associated AKI 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR	"circ_0049271 is up-regulated in LPS-induced HK-2 cells, an in vitro model of sepsis-associated AKI. Functionally, circ_0049271 promotes oxidative stress, apoptosis and inflammatory cytokine secretion, while its knockdown alleviates these injury phenotypes. Mechanistically, circ_0049271 sponges miR-331-3p to increase RUNX1 expression and activate the PI3K/AKT/mTOR pathway."	0.8081
40924303	Biochemical genetics	2025	Upregulation of Hsa_circ_0077007 Expression is Used for Prognosis and Targeted Therapy of Colorectal Cancer.	hsa_circ_0077007	hsa_circ_077007			colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0077007 is up-regulated in CRC serum and CRC cell lines and may serve as a diagnostic and prognostic biomarker, with high expression indicating poorer overall survival. Functionally, hsa_circ_0077007 promotes CRC cell proliferation, migration, and invasion and suppresses apoptosis. Mechanistically, it binds/sponges miR-383-5p, with downstream miR-383-5p targets enriched in CRC-related pathways including p53 signaling."	0.7942
40925424	International journal of biological macromolecules	2025	Circ_IGF2BP1/miR-885-3p/TK1 axis regulates the malignant phenotype and chemotherapeutic resistance of lung adenocarcinoma cells via DNA damage and apoptosis.		Circ_IGF2BP1 	hsa_circ_IGF2BP1	IGF2BP1	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"circ_IGF2BP1 is a human IGF2BP1-derived circular RNA up-regulated in LUAD/NSCLC tissues and LUAD cell lines. It promotes malignant phenotypes and cisplatin resistance by acting as a ceRNA for miR-885-3p, thereby positively regulating TK1 and modulating DNA damage and apoptosis-related pathways. Clinically, its expression shows diagnostic potential and association with T stage, but no significant overall survival association was observed in the limited follow-up cohort."	0.8425
40939177	Cancer research	2025	circADAMTS12 Inhibits the Antitumor Activity of Microglia to Enable Metastatic Colonization in the Brain.		circADAMTS12 	hsa_circ_ADAMTS12	ADAMTS12	breast-to-brain metastasis 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circADAMTS12 is an upregulated oncogenic circRNA in breast-to-brain metastasis. It binds and activates PARP1 to induce IL1B/IL1beta expression, promotes microglial M2-like polarization, upregulates PD-L1 in cancer cells and microglia, and suppresses microglia- and T-cell-mediated antitumor immunity. Targeting circADAMTS12 reduces brain metastatic colonization and can synergize with PD-L1 blockade in immunocompetent mouse models."	0.8769
40944812	Journal of molecular histology	2025	"Knockdown of circ_0000372 elevates PD-L1 level through sponging miR-488-3p to restrain cell viability, motility and immune escape in gastric cancer."	hsa_circ_0000372	circ_0000372			gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circ_0000372 is up-regulated in gastric cancer tissues and cells, and high expression is associated with poor prognosis and advanced clinicopathological features. Functionally, circ_0000372 promotes GC cell proliferation, invasion and immune escape. Mechanistically, it sponges miR-488-3p to positively regulate PD-L1, while circ_0000372 knockdown suppresses tumor growth and immune escape in vivo."	0.7976
40945694	Biochimica et biophysica acta. General subjects	2025	Circ-ATF7IP promotes IL13RA1 dependent M2 polarization of macrophage via sponging MiR-488-3p in papillary thyroid carcinoma.	hsa_circ_0025513	circ-ATF7IP 	hsa_circ_ATF7IP	ATF7IP	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"circ-ATF7IP (hsa_circ_0025513) is up-regulated in LNM-positive PTC and may serve as a diagnostic/predictive biomarker for lymph node metastasis. Functionally, it promotes PTC proliferation, invasion, tumor growth, and macrophage migration by sponging miR-488-3p and modulating the miR-488-3p/IL13RA1 axis, thereby supporting M2 macrophage polarization and tumor microenvironment remodeling."	0.7736
40946511	Ecotoxicology and environmental safety	2025	CircSP3 modulates apoptosis and participates in inorganic arsenic carcinogenesis through phosphorylation and ubiquitination of p65.	hsa_circ_0002642	circSP3	hsa_circ_SP3	SP3	inorganic arsenic carcinogenesis 	MONDO:0004992	cancer	up-regulated	RT-qPCR	"This study shows that NaAsO2 upregulates circSP3 (hsa_circ_0002642) in human A549 lung adenocarcinoma cells. circSP3 functions as an iAs-responsive survival regulator: its knockdown promotes mitochondrial, caspase-dependent apoptosis and attenuates NF-kappaB/p65 signaling by affecting p65 phosphorylation and ubiquitination. circSP3 directly interacts with p65 and IkappaBalpha, implicating a circSP3-p65/IkappaBalpha protein signaling mechanism in inorganic arsenic carcinogenesis."	0.5798
40954198	Oncogene	2025	The novel protein SEMA3C-319aa triggers glutathione metabolism-dependent ferroptosis in gastric cancer.	hsa_circ_0004365	circSEMA3C 	hsa_circ_SEMA3C	SEMA3C	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; RNA-seq	"circSEMA3C is a human SEMA3C-derived circRNA that is downregulated in gastric cancer and encodes the novel protein SEMA3C-319aa. The circSEMA3C/SEMA3C-319aa axis suppresses GC cell proliferation and tumor growth by promoting GSH metabolism-dependent ferroptosis through LDHA nuclear translocation, PARK2-mediated K48-linked GPX4 ubiquitination, and GPX4 degradation. Its reduced expression is associated with advanced stage and lymph node metastasis, and SEMA3C-319aa may improve response to GPX4 inhibition."	0.8837
40955561	Circulation research	2025	Circular RNA Cdr1as Modulates Macrophage-Mediated Cardiac Reparative Function.		circ-cdr1as 	mmu_circ_Cdr1as	CDR1	myocardial infarction 	MONDO:0005068	myocardial infarction	down-regulated	RT-qPCR	"In this mouse myocardial infarction study, circ-cdr1as was downregulated in early post-MI hearts, particularly in macrophages and cardiomyocytes. Overexpression of circ-cdr1as promoted anti-inflammatory M2-like macrophage polarization, reduced cardiomyocyte apoptosis and infarct size, enhanced vascularization, and improved cardiac function. Mechanistically, circ-cdr1as sponged miR-7 to relieve repression of Klf4/KLF4, forming a circ-cdr1as/miR-7/Klf4 immune-regulatory axis."	0.7113
40958523	Neoplasma	2025	N6-methyladenosine-induced hsa_circ_0011536 acts as a microRNA-576-5p sponge to promote ferroptosis of non-small cell lung cancer cells via transferrin receptor.	hsa_circ_0011536		hsa_circ_ZMYM4	ZMYM4	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0011536 is downregulated in NSCLC tissues and cell lines. m6A modification promotes its production from pre-ZMYM4, and hsa_circ_0011536 functions as a hsa-miR-576-5p sponge to increase TFRC expression. Functionally, hsa_circ_0011536 suppresses NSCLC cell proliferation and promotes ferroptosis, suggesting potential therapeutic relevance."	0.6815
40962208	Genomics	2025	Combination of circular RNA-miRNA-mRNA expression profiles and bioinformatic analysis in ovarian endometriosis.	hsa_circ_0005918		hsa_circ_FCHSD2	FCHSD2	ovarian endometriosis 	MONDO:0006337	ovarian endometriosis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005918 is up-regulated in ectopic endometrial tissues and ectopic stromal cells from patients with endometriosis. It promotes endometrial stromal cell migration and invasion through ceRNA axes involving miR-504-5p/PDLIM2 and miR-105-5p/OBSL1, suggesting a role in the progression of endometriotic lesions."	0.704
40970417	Journal of biochemical and molecular toxicology	2025	Targeting the hsa_circ_0000253/miR-7/COL5A2 Axis: Unveiling CCT-018159's Role in Halting Osteosarcoma Progression.	hsa_circ_0000253				Osteosarcoma 	MONDO:0009807	osteosarcoma	up-regulated	Microarray	"This study identifies hsa_circ_0000253 as an up-regulated circRNA in osteosarcoma and prioritizes it as the central circRNA in a ceRNA network. Functional knockdown experiments in U2OS cells indicate that hsa_circ_0000253 promotes OS cell proliferation and migration, likely through the hsa_circ_0000253/miR-7/COL5A2 axis. The evidence for differential expression is based on GEO transcriptome/circRNA profile analysis rather than RT-qPCR validation of disease up-regulation."	0.4546
40975336	International journal of biological macromolecules	2025	CircPRUNE inhibits the proliferation and metastasis of oral squamous cell carcinoma through PTBP3/NOTCH3 signaling axis.	hsa_circ_0014088	circPRUNE 	hsa_circ_PRUNE1	PRUNE1	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR; RNA-seq	"circPRUNE is a human PRUNE1-derived circRNA that is down-regulated in OSCC tissues and cell lines. It suppresses OSCC proliferation, migration, invasion and xenograft tumor growth by binding PTBP3, promoting PTBP3 ubiquitination/degradation, and reducing NOTCH3 mRNA stability and NOTCH3 signaling. The study suggests circPRUNE may serve as a diagnostic biomarker and therapeutic target for OSCC."	0.8932
40986450	Antioxidants & redox signaling	2026	CircGNAQ Promotes Intracranial Aneurysm Formation by Facilitating Vascular Smooth Muscle Cell Phenotypic Switching and Apoptosis.	hsa_circ_0006459	circGNAQ	hsa_circ_GNAQ	GNAQ	Intracranial aneurysm 	MONDO:0005291	brain aneurysm	up-regulated	RT-qPCR; ISH	"This study identifies circGNAQ as an up-regulated circRNA in intracranial aneurysm tissues and plasma. Functionally, circGNAQ promotes IA formation by facilitating VSMC phenotypic switching and apoptosis. Mechanistically, circGNAQ binds SRSF1 and promotes its ubiquitination and proteasome-mediated degradation, suggesting circGNAQ as a potential diagnostic marker and therapeutic target for IA."	0.8146
41005689	Cellular signalling	2025	Exosomal circ_0008803 drives lung cancer cell migration and invasion via NF-kappaB activation.	hsa_circ_0008803		hsa_circ_RNF10	RNF10	non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0008803 is an exosome-enriched RNF10-derived circRNA up-regulated in NSCLC serum exosomes and lung cancer cells. It promotes migration, invasion, metastasis-related phenotypes, and tumor growth by sponging miR-432-5p and binding ELAVL1 to increase TRA2B expression and activate NF-kappaB signaling. Serum exosomal circ_0008803 also shows diagnostic potential and correlates with metastasis and tumor stage."	0.8791
41015145	Archives of biochemistry and biophysics	2025	Construction of a circRNA-miRNA-mRNA ceRNA regulatory network identifies RNAs and genes linked to human ovarian clear cell carcinoma.	hsa_circ_0002822	circKANSL1L	hsa_circ_KANSL1L	KANSL1L	ovarian clear cell carcinoma 	MONDO:0000548	ovarian clear cell cancer	dysregulated	RNA-seq; Microarray	"hsa_circ_0002822 is one of three core dysregulated circRNAs identified in OCCC by integrated GEO dataset analysis. The study proposes that it participates in a circRNA-miRNA-mRNA ceRNA regulatory network linked to oncogenic mRNA networks and immune evasion, but it lacks wet-lab validation."	0.2465
41015145	Archives of biochemistry and biophysics	2025	Construction of a circRNA-miRNA-mRNA ceRNA regulatory network identifies RNAs and genes linked to human ovarian clear cell carcinoma.	hsa_circ_0003641		hsa_circ_ATM	ATM	ovarian clear cell carcinoma 	MONDO:0000548	ovarian clear cell cancer	dysregulated	RNA-seq; Microarray	"hsa_circ_0003641 is a core dysregulated OCCC circRNA derived from the ATM gene. It is incorporated into a predicted circRNA-miRNA-mRNA ceRNA regulatory network associated with oncogenic networks and immune evasion, although the study provides only bioinformatic evidence."	0.2465
41015145	Archives of biochemistry and biophysics	2025	Construction of a circRNA-miRNA-mRNA ceRNA regulatory network identifies RNAs and genes linked to human ovarian clear cell carcinoma.	hsa_circ_0030509				ovarian clear cell carcinoma 	MONDO:0000548	ovarian clear cell cancer	dysregulated	RNA-seq; Microarray	"hsa_circ_0030509 is one of the three core dysregulated circRNAs identified in OCCC across the analyzed GEO datasets. It is predicted to participate in a circRNA-miRNA-mRNA ceRNA network linked to oncogenic miRNA-mRNA regulation and immune evasion, but no experimental validation was performed."	0.2465
41016592	Journal of advanced research	2025	CircCDYL promotes glycolysis to drive the progression of nasopharyngeal carcinoma.	hsa_circ_0008285	circCDYL	hsa_circ_CDYL	CDYL	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circCDYL (hsa_circ_0008285), derived from CDYL exon 2, is overexpressed in nasopharyngeal carcinoma and correlates with clinical and TNM stage. It promotes NPC proliferation, invasion, migration, and metastasis by binding and stabilizing LDHA mRNA, increasing LDHA-driven glycolysis and lactate accumulation. Lactate then promotes AARS1-mediated CFL1 K22 lactylation, increasing CFL1 stability and cytoskeletal remodeling to reduce cell stiffness and adhesion."	0.8826
41027520	International journal of biological macromolecules	2025	Circ_HOMER3 exacerbates inflammatory injury in bovine mammary epithelial cells via TNF/MAPK9 activation and NCOA4-mediated ferroptosis.	bta_circ_0018087	circ_HOMER3 	bta_circ_HOMER3	HOMER3	bovine mastitis 	MONDO:0025100	"mastitis, bovine"	up-regulated	RT-qPCR; RNA-seq	"circ_HOMER3 is up-regulated in E. coli-induced bovine mastitis tissues and LPS-induced bMEC inflammatory injury models. Functionally, it exacerbates inflammatory injury by activating TLR4/NF-kappaB, promotes apoptosis and suppresses proliferation through JAK1/STAT1-related regulation, and amplifies ferroptosis through MAPK9-dependent NCOA4 regulation. The study highlights circ_HOMER3 as a potential molecular target for bovine mastitis intervention."	0.7519
41037404	Cell reports	2025	m6A-mediated circG3BP1 translocation to stress granules promotes nucleation and senescence-linked chemoresistance.	hsa_circ_0003967	circG3BP1	hsa_circ_G3BP1	G3BP1	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; ISH	"circG3BP1/hsa_circ_0003967 is upregulated in ESCC and high expression predicts worse overall survival and poor cisplatin response. Mechanistically, m6A-modified circG3BP1 is recruited to stress granules by IGF2BPs, scaffolds the TIAR-CAPRIN1 complex, represses p21-related senescence-associated mRNA translation, and thereby promotes proliferation and cisplatin chemoresistance."	0.8836
41037850	International immunopharmacology	2025	Experimental investigation of adipose-derived mesenchymal stem cell-derived exosomes in the treatment of osteoporosis via the hsa_circ_0028877/miR-4728-3p/PTCH1 axis.	hsa_circ_0028877				osteoporosis 	MONDO:0005298	osteoporosis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0028877 is up-regulated in PMOP/OVX BMSC contexts and acts as a miR-4728-3p sponge to increase PTCH1, suppress osteogenic gene expression and BMSC osteogenesis, and promote osteoporosis-related pathophysiology. ADSCs-derived exosomes therapeutically improve osteoporosis by inhibiting nuclear export of hsa_circ_0028877, reducing its cytoplasmic ceRNA activity on the hsa_circ_0028877/miR-4728-3p/PTCH1 axis."	0.8385
41055316	Antioxidants & redox signaling	2025	Circular RNA-Directed Therapeutic Strategy for Cold-Induced Diabetic Macrovascular Disease.	hsa_circ_0010154	circRNA9990			cold-climate-induced diabetic macrovascular disease 	MONDO:0005015	diabetes mellitus	up-regulated	RT-qPCR; Microarray	"hsa_circ_0010154 is the main therapeutic target in this study and is up-regulated in DM-MVD/high-glucose endothelial injury. Its silencing improves endothelial proliferation and migration, reduces apoptosis, inflammation, lipid accumulation, and oxidative stress, and AuNPs@ASO plus aerobic exercise ameliorates DM-MVD pathology in vivo."	0.6781
41055316	Antioxidants & redox signaling	2025	Circular RNA-Directed Therapeutic Strategy for Cold-Induced Diabetic Macrovascular Disease.	hsa_circ_0002465	circRNA9734			diabetic macrovascular disease 	MONDO:0000960	diabetic peripheral angiopathy	up-regulated	RT-qPCR; Microarray	"hsa_circ_0002465 was identified as an up-regulated circRNA in HG-treated HUVECs/DM-MVD and analyzed mainly by bioinformatics as part of a predicted circRNA-miRNA-mRNA network. Unlike hsa_circ_0010154, its silencing did not affect HUVEC proliferation, and the study did not pursue detailed functional validation for this circRNA."	0.4474
41055316	Antioxidants & redox signaling	2025	Circular RNA-Directed Therapeutic Strategy for Cold-Induced Diabetic Macrovascular Disease.	hsa_circ_0004843				diabetic macrovascular disease 	MONDO:0000960	diabetic peripheral angiopathy	up-regulated	RT-qPCR; Microarray	"hsa_circ_0004843 was identified as an up-regulated circRNA in HG-treated HUVECs/DM-MVD and analyzed mainly through predicted circRNA-miRNA-mRNA regulatory networks. Its predicted targets were enriched in apoptosis, proliferation/growth, signal transduction, and cellular stress-related processes, but silencing hsa_circ_0004843 did not affect HUVEC proliferation and no further disease-function experiments were pursued."	0.4474
41062012	Experimental eye research	2025	circ-0007006 attenuates fibrosis in thyroid-associated ophthalmopathy by stabilizing HBEGF expression in vitro.	hsa_circ_0007006	circ-0007006 	hsa_circ_DYM	DYM	Thyroid-associated ophthalmopathy 	MONDO:0001509	endocrine exophthalmos	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0007006 is downregulated in fibrotic type II TAO tissues. In orbital fibroblasts, circ-0007006 attenuates fibrotic activation by suppressing ECM/fibrotic markers and SMAD2/3 phosphorylation, while reducing proliferation and increasing apoptosis. Mechanistically, it functions as a ceRNA for miR-383-3p to stabilize HBEGF expression, forming the circ-0007006/miR-383-3p/HBEGF anti-fibrotic axis with potential therapeutic value."	0.8598
41069093	International archives of allergy and immunology	2025	RNA-editing enzyme ADAR1 attenuates rheumatoid arthritis via regulating fibroblast-like synoviocytes-derived exosomal circFTO.		circFTO	hsa_circ_FTO	FTO	Rheumatoid arthritis 	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"circFTO is an FLS-derived exosomal circRNA that is up-regulated in RA-FLSs and in the RA-FLS SCID-HuRAg model. The study suggests that ADAR1 attenuates RA-associated inflammation and cartilage degradation at least partly by downregulating exosomal circFTO, with associated changes in miR-548a-3p and hnRNPA2B1 expression."	0.5358
41069159	Journal of leukocyte biology	2025	CircNR3C1 promotes acute lymphoblastic leukemia progression via the MSI2/ENO1/RPS3 axis.		circNR3C1	hsa_circ_NR3C1	NR3C1	acute lymphoblastic leukemia 	MONDO:0004967	acute lymphoblastic leukemia	up-regulated	RT-qPCR	"circNR3C1 is upregulated in B-ALL cell lines and acts as an oncogenic circRNA in ALL models. It promotes proliferation, cell cycle progression, tumor growth, and survival while inhibiting apoptosis by stabilizing MSI2 protein, enhancing ENO1 mRNA stability, and increasing ENO1/RPS3 expression; it also regulates inflammatory NF-kappaB signaling through a miR-515-5p/TLR8 axis."	0.8478
41075359	Archives of oral biology	2025	Hsa_circ_0007349 upregulates glutamate-ammonia ligase to modulate gingival fibroblast wound healing.	hsa_circ_0007349		hsa_circ_USP3	USP3	periodontitis 	MONDO:0005076	periodontitis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0007349 is upregulated in periodontitis gingival tissues and LPS-treated HGFs. It acts as a ceRNA that sponges miR-127-5p, thereby increasing GLUL expression and promoting HGF proliferation, migration, wound healing, and ECM turnover. The downstream GLUL-related mechanism was also linked to periodontal tissue destruction and alveolar bone loss in an experimental periodontitis mouse model."	0.8142
41075905	International journal of biological macromolecules	2025	CircPFKP orchestrates a novel competing endogenous RNA network to regulate SPRY4/p38-MAPK signaling and modulate papillary thyroid carcinoma aggressiveness.	hsa_circ_0006608		hsa_circ_PFKP	PFKP	Papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"circPFKP is an upregulated circRNA in PTC derived from PFKP exons 18 and 19. It mainly localizes to the cytoplasm and acts as a ceRNA sponge for miR-4516 to upregulate SPRY4, thereby modulating p38 MAPK signaling. Functionally, circPFKP suppresses proliferation, migration, invasion, and tumorigenicity under baseline conditions, but it also reduces apoptosis under stress or irradiation, suggesting a dual role and therapeutic relevance in PTC."	0.7898
41084478	Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica	2025	[Mechanism of Tougu Xiaotong Capsules in alleviating glycolytic metabolism disorder of chondrocytes in osteoarthritis by modulating circFOXO3].		circFOXO3 	mmu_circ_FOXO3	FOXO3	osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR; ISH	"In mouse osteoarthritis cartilage and IL-1beta-induced chondrocytes, circFOXO3 is down-regulated. Tougu Xiaotong Capsules upregulate circFOXO3, thereby inhibiting glycolytic metabolism-related proteins and MMP13, improving extracellular matrix metabolic balance, and delaying osteoarthritis degeneration; silencing circFOXO3 weakens these effects."	0.4469
41086588	"Pathology, research and practice"	2025	CircRBM33 facilitates colorectal cancer progression by regulating the miR-512-5p/SLC1A5 axis.	hsa_circ_0001772	circRBM33 	hsa_circ_RBM33		colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"CircRBM33 is up-regulated in colorectal cancer tissues and cell lines. It promotes CRC cell proliferation, migration, xenograft tumor growth and glutamine metabolism while suppressing apoptosis, at least partly through a ceRNA mechanism involving miR-512-5p and SLC1A5. The study proposes circRBM33 as a potential therapeutic target for CRC."	0.7859
41087791	Journal of molecular histology	2025	Exosomes from hypoxic pre-treated BMSCs protect against lipopolysaccharide-induced acute lung injury via delivery of circ-LRP6.	mmu_circ_0001529		mmu_circ_LRP6	LRP6	acute lung injury 	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR; RNA-seq	"circ-LRP6 is enriched in hypoxia-pretreated BM-MSC-derived exosomes and is delivered to protect against LPS-induced acute lung injury. Knockdown of circ-LRP6 reduces the therapeutic effect of hypoxic exosomes, worsening apoptosis, inflammation, lung injury, and survival outcomes in the ALI model. The study suggests that circ-LRP6 acts at least partly by modulating Claudin 4 expression."	0.6287
41099193	IUBMB life	2025	Gastric Cancer Cell-Derived Exosomes Induce Macrophage M2 Polarization by Delivering circSMARCC1 to Promote Gastric Cancer Progression.		circSMARCC1 	hsa_circ_SMARCC1	SMARCC1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circSMARCC1 is up-regulated in gastric cancer tissues, cell lines, and circulating exosomes, and high expression is associated with poor survival. Functionally, circSMARCC1 promotes STAD cell proliferation, invasion, tumor growth, and macrophage M2 polarization. Mechanistically, STAD cell-derived exosomes deliver circSMARCC1 to macrophages, where it increases U2AF2 expression and drives M2 polarization to promote STAD progression."	0.6482
41113974	American journal of cancer research	2025	Circular RNA hsa_circ_0002669 is down-regulated by Helicobacter pylori and inhibits the gastric cancer progression via miR-223-3p/ARID1A axis.	hsa_circ_0002669		hsa_circ_DOCK1	DOCK1	gastric cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0002669 is down-regulated in gastric cancer tissues and GC cell lines, and H. pylori infection further decreases its expression. It functions as a tumor-suppressive circRNA that inhibits GC cell proliferation, migration, invasion, tumor growth, and lung metastasis. Mechanistically, cytoplasmic hsa_circ_0002669 sponges miR-223-3p to increase ARID1A protein expression, supporting its potential as a diagnostic marker and therapeutic target."	0.8366
41115968	In vitro cellular & developmental biology. Animal	2025	Circular RNA hsa_circ_0124644 regulates apoptosis of endothelial cells in coronary artery disease.	hsa_circ_0124644				coronary artery disease 	MONDO:0005010	coronary artery disorder	down-regulated	RT-qPCR	"This study found that hsa_circ_0124644 is down-regulated in TNF-alpha-stimulated endothelial cells used to model the CAD vascular microenvironment. Overexpression of hsa_circ_0124644 reduced endothelial cell apoptosis, improved cell viability, increased Bcl-2, and decreased Bax, suggesting a protective role in CAD-related endothelial injury."	0.4546
41120080	International journal of biological macromolecules	2025	Phase separation of circCHD6-encoded 216aa protein promotes colorectal cancer metastasis.	hsa_circ_0001159	circCHD6	hsa_circ_CHD6	CHD6	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"circCHD6 is up-regulated in colorectal cancer and higher expression is associated with poorer patient prognosis. It encodes circCHD6-216aa, a pro-metastatic protein that forms nuclear LLPS condensates, enhances circCHD6 biogenesis through DHX9 phosphorylation, and stabilizes NCL phase separation to promote CD44 transcription and CRC metastasis."	0.9013
41123576	Analytical chemistry	2025	An Ultrasensitive and Robust CircRNA Nanobiosensor via Magnetic Control Depuration and Catalytic Hairpin Assembly Cascade Amplification for Clinically Accessible Liquid Biopsy.	hsa_circ_0001445	cSMARCA5	hsa_circ_SMARCA5	SMARCA5	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"This study developed and clinically validated a CHA cascade amplification and magnetic control depuration nanobiosensor to quantify cSMARCA5 in liver tissue and whole blood. cSMARCA5 was significantly downregulated in HCC tissues and peripheral venous blood from HCC patients, and its measurement could differentiate HCC patients from normal people, supporting its use as a liquid biopsy biomarker for HCC screening."	0.2995
41128953	Japanese journal of ophthalmology	2025	Transcriptome RNA sequencing reveals the global molecular responses and circRNA-miRNA-lncRNA interaction network in cataract.	hsa_circ_0026233				Cataract 	MONDO:0005129	cataract	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0026233 was one of the differentially expressed circRNAs in cataract-related lens samples/cell model with high predicted coding potential. The study selected it for predicted ceRNA/RBP interaction analysis, but no downstream lncRNA target detected in the authors' RNA-seq data was reported and no functional mechanism was experimentally validated."	0.4685
41128953	Japanese journal of ophthalmology	2025	Transcriptome RNA sequencing reveals the global molecular responses and circRNA-miRNA-lncRNA interaction network in cataract.	hsa_circ_0006388				Cataract 	MONDO:0005129	cataract	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0006388 was down-regulated in cataract-related RNA-seq data and selected after RT-PCR-consistent expression screening because of high predicted coding potential. The authors propose that a hsa_circ_0006388-miR-378g-AC008738.7 ncRNA network may regulate cataract formation, potentially through apoptosis regulation and targeting the Wnt signaling pathway, but detailed downstream mechanistic experiments remain lacking."	0.4685
41135075	Critical reviews in eukaryotic gene expression	2025	The circRHOBTB3/EIF4A3/NF-kappaB Axis Promotes Progression of Atopic Dermatitis.		circRHOBTB3 	hsa_circ_RHOBTB3	RHOBTB3	atopic dermatitis 	MONDO:0002406	dermatitis	up-regulated	RT-qPCR	"circRHOBTB3 is up-regulated in an IL-4-induced HaCaT cell model of atopic dermatitis and is predominantly cytoplasmic. Its knockdown suppresses inflammatory cytokine release, proliferation, and migration, while mechanistically circRHOBTB3 interacts with EIF4A3 to activate NF-kappaB signaling and forms a positive feedback loop with NF-kappaB transcriptional regulation."	0.7545
41136871	Annals of surgical oncology	2026	circ_PPAPDC1A is Associated with Brain Metastasis of Non-Small-Cell Lung Cancer via the miR-30a-3p/SPOCK1 Pathway.		circ_PPAPDC1A 	hsa_circ_PPAPDC1A	PPAPDC1A	non-small-cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_PPAPDC1A is upregulated in circulating exosomes from NSCLC patients with brain metastasis and in brain-metastatic NSCLC cell lines. It promotes proliferation, suppresses apoptosis, and enhances BBB penetration in vitro by sponging miR-30a-3p and upregulating SPOCK1. Its exosomal expression has potential diagnostic and prognostic value for NSCLC brain metastasis."	0.7878
41138302	International immunopharmacology	2025	Exosomal co-delivery of CircRNA-TRAPPC6B and rifampicin for enhanced immunotherapy against tuberculosis.		CircRNA-TRAPPC6B 	hsa_circ_TRAPPC6B	TRAPPC6B	tuberculosis 	MONDO:0018076	tuberculosis	down-regulated	RT-qPCR; RNA-seq	"circTRAPPC6B is the functional anti-TB circRNA cargo delivered by engineered mannose-modified exosomes together with rifampicin. Its delivery increases intracellular circTRAPPC6B in Mtb-infected macrophages, promotes autophagy-mediated host immunological killing of intracellular Mtb, reduces bacterial burdens, and alleviates lung inflammation in infected mice."	0.6536
41138842	Experimental cell research	2025	EIF4A3-mediated localization of circDNAJC16 sequesters miR-93-5p to suppress lung adenocarcinoma progression via CDKN1A-regulated cell cycle and EMT.	hsa_circ_0000018	circDNAJC16 	hsa_circ_DNAJC16	DNAJC16	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; Microarray	"circDNAJC16 (hsa_circ_0000018) is a human DNAJC16-derived circRNA downregulated in LUAD tissues, with low expression associated with advanced stage, lymph node metastasis and poor overall survival. Functionally, circDNAJC16 suppresses LUAD proliferation, tumor growth, migration and invasion by sponging miR-93-5p and activating CDKN1A/p21-mediated G0/G1 arrest, while also inhibiting EMT and potentially Wnt/beta-catenin/STAT3 signaling. eIF4A3 binds upstream flanking regions of DNAJC16/circDNAJC16 and regulates circDNAJC16 subcellular localization, supporting its role as a prognostic biomarker and therapeutic target."	0.8981
41145815	Cell death and differentiation	2025	circTGFBR2(3-6) acts as an assembly platform for RNA-binding protein IGF2BP3 and TGFBR1 mRNA to enhance breast cancer cell plasticity.	hsa_circ_0064654	circTGFBR2(3-6) 	hsa_circ_TGFBR2	TGFBR2	triple-negative breast carcinoma	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"circTGFBR2(3-6), a TGFBR2-derived human circRNA, enhances breast cancer cell plasticity by potentiating TGF-beta/SMAD signaling. It acts as a non-coding scaffold for IGF2BP3 and TGFBR1 mRNA, promoting m6A-dependent TGFBR1 mRNA stabilization and thereby driving EMT, migration, extravasation, stemness, and chemotherapeutic drug resistance."	0.8187
41148210	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2025	UCMSCs-Derived Exosomal circHIPK3 Restrains Oxidative Stress and Inflammation by Downregulating the Stability of HMGB1 mRNA via Recruiting UPF1 in Diabetes Foot Ulcer.		circHIPK3 	hsa_circ_HIPK3		diabetic foot ulcers 	MONDO:0000960	diabetic peripheral angiopathy	down-regulated	RT-qPCR	"UCMSCs-derived exosomal circHIPK3 functions as a protective circRNA in DFU models by reducing HG-induced oxidative stress and inflammatory injury in endothelial cells. Mechanistically, circHIPK3 directly interacts with UPF1, increases UPF1 expression, and suppresses HMGB1 mRNA stability, leading to inhibition of the HMGB1/RAGE axis and improved wound healing."	0.6945
41166894	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2025	AS-IV inhibits the progression of ovarian cancer by targeting the circ_0124787/miR-6875-3p/IL-1beta axis.	hsa_circ_0124787	circ_0124787			ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; Microarray	"circ_0124787 is upregulated in ovarian cancer tissues and acts as an oncogenic circRNA in the AS-IV response context. It sponges miR-6875-3p to increase IL-1beta secretion, thereby promoting gammadeltaT17-related inflammatory immune regulation and ovarian tumor growth; AS-IV suppresses ovarian cancer progression by downregulating this circ_0124787/miR-6875-3p/IL-1beta pathway."	0.7283
41169059	ACS biomaterials science & engineering	2025	GelMA Hydrogel Loading circNEFM-Engineered Exosomes Inhibits Glioma Growth.	hsa_circ_0083682	circNEFM 	hsa_circ_NEFM	NEFM	glioma 	MONDO:0021042	glioma	down-regulated	Microarray	"circNEFM is a downregulated human circRNA in glioma tissues identified from GSE109569. In this study, circNEFM overexpression and circNEFM-loaded engineered exosomes inhibited U87 glioma cell proliferation and increased vincristine chemosensitivity through a ceRNA mechanism involving miR-1248/BCL6B and miR-1236/C1orf115. Aptamer-modified exo-circNEFM delivered by a GelMA hydrogel scaffold showed sustained release and anti-glioma therapeutic potential."	0.4546
41172552	Revista de investigacion clinica; organo del Hospital de Enfermedades de la Nutricion	2025	Circ-CCDC66 promoted breast cancer progression via miR-4259-mediated upregulation of CCDC66.		circ-CCDC66 	hsa_circ_CCDC66	CCDC66	breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ-CCDC66 is up-regulated in breast cancer tissues and cell lines. It promotes breast cancer cell proliferation and mammosphere/stem cell spheroidization, at least partly by sponging hsa-miR-4259 and increasing CCDC66 expression. The study proposes the circ-CCDC66/miR-4259/CCDC66 axis as a potential therapeutic target in breast cancer."	0.8111
41175999	International journal of biological macromolecules	2025	CircRAB23 functions as miR-532-3p sponge to promote the malignant proliferation and metastasis of intrahepatic cholangiocarcinoma through HMGA2-EMT axis.	hsa_circ_0004119	circRAB23 	hsa_circ_RAB23	RAB23	intrahepatic cholangiocarcinoma 	MONDO:0003210	intrahepatic cholangiocarcinoma	up-regulated	RT-qPCR	"circRAB23 (hsa_circ_0004119), derived from RAB23, is up-regulated in ICC tissues and cell lines and is associated with aggressive clinicopathologic features and poor survival. It promotes ICC proliferation, migration, invasion, metastasis, and EMT by sponging miR-532-3p and upregulating HMGA2, supporting its potential as a diagnostic and therapeutic target."	0.8557
41186777	Molecular biology reports	2025	Circ-MYO9B modulates metabolic pathways in nonalcoholic steatohepatitis via miR-193b-5p.		circ-MYO9B 	hsa_circ_MYO9B	MYO9B	nonalcoholic steatohepatitis 	MONDO:0007027	metabolic dysfunction-associated steatohepatitis	dysregulated	RT-qPCR	"This study reports that circ-MYO9B is dysregulated in NASH-CH, with upregulation in liver tissue and downregulation in blood. circ-MYO9B directly interacts with and regulates hsa-miR-193b-5p, potentially influencing FOXO3-related and metabolic processes including lipogenesis, inflammation, apoptosis, and glucose metabolism. The authors propose circ-MYO9B as a potential diagnostic biomarker and therapeutic target, although functional validation in hepatocyte models remains needed."	0.6986
41187355	Biosensors & bioelectronics	2026	Machine learning-assisted renewable and polarity-switchable photoelectrochemical biosensor for circRNA intelligent diagnosis.		circSATB2 	hsa_circ_SATB2	SATB2	lung cancer 	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"This study developed a renewable polarity-switchable PEC biosensor to quantify circSATB2 in human whole blood. circSATB2 was significantly higher in lung cancer patients than in healthy individuals, and its measured level supported machine-learning-based intelligent diagnosis of lung cancer."	0.459
41187421	International immunopharmacology	2026	CircP4HA3/miR-5001-5p/THBS2 axis promotes chondrocyte senescence and cartilage degradation during osteoarthritis progression.		CircP4HA3 	hsa_circ_P4HA3	P4HA3	Osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; ISH; RNA-seq	"CircP4HA3 is a P4HA3-derived human circRNA upregulated in osteoarthritic cartilage and inflammatory chondrocytes. It promotes OA progression by sponging miR-5001-5p, increasing THBS2 expression, activating MAPK/p38 signaling, and driving extracellular matrix breakdown and chondrocyte senescence. CircP4HA3 knockdown protects cartilage in vitro and in a DMM-induced rat OA model, suggesting therapeutic potential."	0.8661
41199071	Biological trace element research	2026	Aluminum Exposure Leads to Abeta Deposition via the ciRs-7 Pathway.		ciRs-7 	rno_circ_CDR1	CDR1	Alzheimer's disease 	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR	"This study identifies ciRs-7 as a down-regulated circRNA in aluminum-induced neurotoxicity models. Reduced ciRs-7 releases miR-7 activity, leading to decreased UBE2A expression and increased Abeta deposition, while ciRs-7 overexpression reverses these pathological changes and mitigates cellular injury."	0.414
41201114	Archives of physiology and biochemistry	2025	Circular RNA ribosomal protein L15 accelerates epithelial mesenchymal transformation and tumour growth in non-small cell lung carcinoma via modulating the microRNA-518c-3p/WD repeat protein 1 axis.		circ-RPL15 	hsa_circ_RPL15	RPL15	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ-RPL15 is up-regulated in NSCLC tissues and cell lines and its high expression is associated with worse 5-year survival. Functionally, circ-RPL15 promotes NSCLC cell proliferation, migration, invasion, EMT and xenograft tumour growth while suppressing apoptosis. Mechanistically, it targets miR-518c-3p to regulate WDR1 expression, forming a circ-RPL15/miR-518c-3p/WDR1 oncogenic axis."	0.8202
41203147	International journal of biological macromolecules	2025	Circular RNA Gsr-0002 promotes schistosomiasis-induced liver fibrosis by regulating the DNMT3A/PTEN pathway.		circGsr-0002 	mmu_circ_Gsr	Gsr	schistosomiasis-induced liver fibrosis 	MONDO:0015254	schistosomiasis	up-regulated	RT-qPCR; RNA-seq	"circGsr-0002 is a mouse circRNA derived from Gsr that is up-regulated in primary HSCs and liver tissues during schistosomiasis-induced liver fibrosis. It promotes HSC activation and proliferation and contributes to liver fibrosis by sponging miR-383-3p and modulating the DNMT3A/PTEN pathway. Knockdown of circGsr-0002 suppresses HSC activation/proliferation, induces apoptosis, and alleviates schistosome-induced hepatic fibrosis in mice."	0.8029
41204684	British journal of pharmacology	2026	CircPTK2 enhances non-small cell lung cancer proliferation by inhibiting cellular senescence through stabilizing NFYA and elevating FOXM1.	hsa_circ_0005273	circPTK2 	hsa_circ_PTK2	PTK2	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circPTK2 is up-regulated in NSCLC tissues and cell lines and its high expression predicts poor overall survival. Functionally, circPTK2 promotes NSCLC proliferation and tumorigenicity while suppressing cellular senescence. Mechanistically, circPTK2 binds MDM2 to inhibit MDM2-mediated NFYA ubiquitination and degradation, stabilizing NFYA and increasing FOXM1 transcription."	0.9028
41205482	Veterinary microbiology	2025	Decoding host immune response: circRNAs in Klebsiella variicola-infected chicken spleens.		circRNA_4562			Klebsiella variicola infection 	MONDO:0030603	Klebsiella infectious disease	dysregulated	RT-qPCR; RNA-seq	"circRNA_4562 is a K. variicola infection-associated dysregulated chicken circRNA. The study supports a ceRNA role in which circRNA_4562 sponges gga-miR-3537 to increase CARD11 expression, contributing to host immune and inflammatory responses against infection."	0.6328
41205482	Veterinary microbiology	2025	Decoding host immune response: circRNAs in Klebsiella variicola-infected chicken spleens.		circRNA_0366			Klebsiella variicola infection 	MONDO:0030603	Klebsiella infectious disease	dysregulated	RT-qPCR; RNA-seq	"circRNA_0366 is a K. variicola infection-associated dysregulated chicken circRNA. The study supports a ceRNA role in which circRNA_0366 sponges gga-miR-129-5p to increase ITPR2 expression, contributing to host immune and inflammatory responses against infection."	0.6328
41208534	Journal of biochemical and molecular toxicology	2025	CircCGNL1 Suppresses Nasopharyngeal Carcinoma Progression by Targeting IGF2BP3 and Inhibiting AKT/mTOR Signaling.	hsa_circ_0035432	circCGNL1	hsa_circ_CGNL1	CGNL1	Nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	down-regulated	RT-qPCR	"circCGNL1 is downregulated in nasopharyngeal carcinoma and functions as a tumor-suppressive circRNA. It directly interacts with the RNA-binding protein IGF2BP3, reduces phosphorylation of AKT and mTOR, inhibits AKT/mTOR signaling, and thereby suppresses NPC proliferation, migration, invasion, and tumor growth while promoting apoptosis. The study suggests circCGNL1 as a potential diagnostic biomarker and therapeutic target for NPC."	0.8625
41213059	"Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer"	2025	Increased hsa_circ_0075829 Facilitates the Progression of Gastric Cancer and Its Relationship with Helicobacter Pylori Infection.	hsa_circ_0075829	circ_0075829			gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"hsa_circ_0075829/circ_0075829 is up-regulated in gastric cancer tissues and cells, especially in H. pylori-positive contexts. It promotes gastric cancer cell proliferation, migration, and invasion through a miR-149-5p/AGO1 regulatory axis, and high circ_0075829 expression is associated with worse overall survival and adverse clinicopathological features."	0.7283
41217985	Journal of biochemical and molecular toxicology	2025	"CircRNA_0004104 Participates in Regulating Trophoblast Invasion, Migration and Oxidative Stress in Pre-eclampsia Through microRNA-198."	hsa_circ_0004104	CircRNA_0004104 	hsa_circ_SPARC	SPARC	Pre-eclampsia 	MONDO:0005081	preeclampsia	down-regulated	RT-qPCR; Microarray	"circ_0004104 is downregulated in plasma and placental samples from PE patients, especially in severe PE. Functionally, circ_0004104 promotes trophoblast invasion and migration and suppresses oxidative stress by sponging miR-198, thereby restraining PE progression. Clinically, plasma circ_0004104 may help distinguish severe PE from mild PE, particularly when combined with the sFlt-1/PlGF ratio."	0.8244
41224057	International journal of biological macromolecules	2025	CircSETD2 impairs hepatic lipid homeostasis in metabolic dysfunction-associated fatty liver disease by binding CPS1.	hsa_circ_0005870	circSETD2 	hsa_circ_SETD2	SETD2	metabolic dysfunction-associated fatty liver disease 	MONDO:0013209	metabolic dysfunction-associated steatotic liver disease	up-regulated	RT-qPCR; RNA-seq	"Human circSETD2 is a SETD2-derived circRNA significantly upregulated in MAFLD patient liver tissues and FFA-treated HepG2 cells. It promotes lipid metabolic dysregulation by binding CPS1 and reducing CPS1 enzymatic activity, thereby increasing lipogenesis and lipid accumulation while suppressing fatty acid beta-oxidation."	0.8335
41224057	International journal of biological macromolecules	2025	CircSETD2 impairs hepatic lipid homeostasis in metabolic dysfunction-associated fatty liver disease by binding CPS1.		mmu-circSETD2 	mmu_circ_Setd2	Setd2	metabolic dysfunction-associated fatty liver disease 	MONDO:0013209	metabolic dysfunction-associated steatotic liver disease	up-regulated	RT-qPCR	"Murine mmu-circSETD2 is upregulated in livers of HFD-fed MAFLD mice. Liver-specific silencing of mmu-circSETD2 reduces hepatic lipid accumulation, improves liver function and hyperlipidemia, decreases lipid synthesis, increases fatty acid beta-oxidation, and modulates disease through CPS1-dependent mechanisms."	0.4635
41234080	Zhongguo shi yan xue ye xue za zhi	2025	[CircRAD18 Regulates Daunorubicin Resistance in Acute Myeloid Leukemia Cells through MiR-185-5p/HDGF Axis].		CircRAD18 	hsa_circ_RAD18	RAD18	acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"This study shows that CircRAD18 is up-regulated in the human AML daunorubicin-resistant KG1a cell line. CircRAD18 promotes DNR resistance by targeting miR_185_5p and increasing HDGF expression; knockdown of CircRAD18 restores DNR sensitivity, inhibits proliferation, and promotes apoptosis."	0.5607
41237467	Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy	2026	Y10 phosphorylation of LDHA promotes the release of extracellular vesicle-derived circSEPT9 to enhance the chemoresistance of triple negative breast cancer cells via modulation of the miR-515-5p/KIAA1429 axis.		circSEPT9 	hsa_circ_SEPT9	SEPT9	triple negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"circSEPT9 is upregulated in DOX-resistant TNBC tissues, cells, plasma, and EVs. LDHA Y10 phosphorylation promotes EV-mediated circSEPT9 release and transfer to sensitive TNBC cells, where circSEPT9 sponges miR-515-5p, upregulates KIAA1429, enhances m6A methylation, and promotes proliferation, invasion, tumor growth, and chemoresistance. EV-circSEPT9 also shows diagnostic potential for identifying DOX resistance in TNBC."	0.8655
41237839	Cellular signalling	2026	METTL3-mediated m6A modification of circCDYL promotes gastric cancer progression by acting as miR-378a-5p sponge to regulate USP13 expression.	hsa_circ_0008285	circCDYL	hsa_circ_CDYL	CDYL	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"This study identifies human circCDYL (hsa_circ_0008285) as an up-regulated oncogenic circRNA in gastric cancer. METTL3-mediated m6A modification enables YTHDC1-dependent nuclear export of circCDYL, and cytoplasmic circCDYL promotes GC progression by sponging miR-378a-5p to increase USP13 expression. CircCDYL is proposed as a potential diagnostic biomarker and therapeutic target for gastric cancer."	0.8536
41241017	Biochemical pharmacology	2026	Circ_0057582 inhibits breast cancer progression via hnRNPF/YAP/SOX9 axis and M2 polarization in TAMs by autophagic degradation of ISG15.	hsa_circ_0057582	circ_0057582	hsa_circ_HECW2	HECW2	breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	"circ_0057582 is a downregulated tumor-suppressive circRNA in breast cancer tissues, serum, and cell lines. It inhibits breast cancer growth, proliferation, migration, and invasion through binding hnRNPF and destabilizing YAP mRNA, thereby reducing SOX9. It also promotes autophagic degradation of ISG15 to reduce secreted ISG15 and suppress M2 polarization of tumor-associated macrophages, and shows potential as a serum diagnostic biomarker."	0.8933
41248794	International journal of biological macromolecules	2025	"Circ_GLS/miR-410-3p/GSK3beta/beta-catenin axis modulates malignant phenotypes of non-small cell lung cancer cells via regulation of cell cycle, apoptosis, ferroptosis, and EMT."		circRNA_22709 	hsa_circ_GLS	GLS	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Northern Blot; RNA-seq	"circ_GLS is a GLS-derived human circRNA that is downregulated in NSCLC tumor tissues. It suppresses malignant NSCLC phenotypes by sponging miR-410-3p and positively regulating GSK3beta, thereby inhibiting beta-catenin signaling and EMT, restraining cell-cycle progression, and promoting apoptosis and ferroptosis. Clinically, higher circ_GLS expression is associated with better overall survival and shows diagnostic potential in NSCLC tissues."	0.8868
41248794	International journal of biological macromolecules	2025	"Circ_GLS/miR-410-3p/GSK3beta/beta-catenin axis modulates malignant phenotypes of non-small cell lung cancer cells via regulation of cell cycle, apoptosis, ferroptosis, and EMT."		circRNA_22709 	hsa_circ_GLS	GLS	lung adenocarcinoma	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; Northern Blot; RNA-seq	"circ_GLS is a GLS-derived human circRNA that is downregulated in NSCLC tumor tissues. It suppresses malignant NSCLC phenotypes by sponging miR-410-3p and positively regulating GSK3beta, thereby inhibiting beta-catenin signaling and EMT, restraining cell-cycle progression, and promoting apoptosis and ferroptosis. Clinically, higher circ_GLS expression is associated with better overall survival and shows diagnostic potential in NSCLC tissues."	0.8868
41248794	International journal of biological macromolecules	2025	"Circ_GLS/miR-410-3p/GSK3beta/beta-catenin axis modulates malignant phenotypes of non-small cell lung cancer cells via regulation of cell cycle, apoptosis, ferroptosis, and EMT."		circRNA_22709 	hsa_circ_GLS	GLS	lung squamous cell carcinoma	MONDO:0005097	squamous cell lung carcinoma	down-regulated	RT-qPCR; Northern Blot; RNA-seq	"circ_GLS is a GLS-derived human circRNA that is downregulated in NSCLC tumor tissues. It suppresses malignant NSCLC phenotypes by sponging miR-410-3p and positively regulating GSK3beta, thereby inhibiting beta-catenin signaling and EMT, restraining cell-cycle progression, and promoting apoptosis and ferroptosis. Clinically, higher circ_GLS expression is associated with better overall survival and shows diagnostic potential in NSCLC tissues."	0.8868
41249488	Oncogene	2025	Circular RNA CLASP1 modulates the GLI1/SNAIL axis and enhances macrophage polarization in breast cancer.			hsa_circ_CLASP1	CLASP1	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	"circCLASP1 is upregulated in breast cancer tissues, serum, and cell lines and is associated with lymph node metastasis, Ki67 expression, tumor size, and diagnostic ROC performance. Functionally, it promotes breast cancer proliferation, migration, invasion, tumor growth, macrophage recruitment/M2-like polarization, and lung metastasis. Mechanistically, U2AF2 promotes circCLASP1 biogenesis, while circCLASP1 acts mainly as a CCT2-GLI1 protein scaffold to stabilize GLI1 through inhibition of ubiquitin-mediated degradation, activate the GLI1/SNAIL/CCL2-CCL5 axis, and remodel the tumor microenvironment independently of miR-15a-5p sponging."	0.8953
41249488	Oncogene	2025	Circular RNA CLASP1 modulates the GLI1/SNAIL axis and enhances macrophage polarization in breast cancer.			mmu_circ_Clasp1	Clasp1	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	"circCLASP1 is upregulated in breast cancer tissues, serum, and cell lines and is associated with lymph node metastasis, Ki67 expression, tumor size, and diagnostic ROC performance. Functionally, it promotes breast cancer proliferation, migration, invasion, tumor growth, macrophage recruitment/M2-like polarization, and lung metastasis. Mechanistically, U2AF2 promotes circCLASP1 biogenesis, while circCLASP1 acts mainly as a CCT2-GLI1 protein scaffold to stabilize GLI1 through inhibition of ubiquitin-mediated degradation, activate the GLI1/SNAIL/CCL2-CCL5 axis, and remodel the tumor microenvironment independently of miR-15a-5p sponging."	0.8953
41250776	Cytotechnology	2025	CircUSP36 promotes FBXO5 expression to accelerate cervical cancer progression by targeting miR-520d-5p.		circUSP36 	hsa_circ_USP36	USP36	cervical cancer	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"CircUSP36 is up-regulated in cervical cancer cell lines and acts as an oncogenic circRNA. It promotes proliferation, invasion, and migration and suppresses apoptosis by competitively binding miR-520d-5p, thereby increasing FBXO5 expression."	0.5627
41261546	Zhongguo zhen jiu = Chinese acupuncture & moxibustion	2025	"[Effects of moxibustion at ""Feishu"" (BL13) and ""Xinshu"" (BL15) on myocardial circPAN3, FOXO3, BNIP3 levels and myocardial fibrosis in rats with chronic heart failure]."			rno_circ_Pan3	Pan3	chronic heart failure 	MONDO:0005252	heart failure	down-regulated	RT-qPCR	"In LAD ligation-induced CHF rats, myocardial circPAN3 expression was decreased compared with normal rats. Moxibustion at Feishu (BL13) and Xinshu (BL15) increased circPAN3 expression and alleviated myocardial fibrosis, potentially by reducing FOXO3 and BNIP3 expression and inhibiting excessive myocardial autophagy."	0.414
41274252	Biochemical and biophysical research communications	2025	Exosomal circ_0058493 promotes imatinib resistance via miR-548b-3p/U2SURP axis in CML cells.	hsa_circ_0058493	circ_0058493			Chronic myelogenous leukemia 	MONDO:0011996	"chronic myelogenous leukemia, BCR-ABL1 positive"	up-regulated	RT-qPCR	"This study identifies exosomal hsa_circ_0058493/circ_0058493 as a promoter of imatinib resistance in CML. It can be transferred from imatinib-resistant K562/G01 cells to imatinib-sensitive K562 cells via exosomes, where it sponges miR-548b-3p, increases U2SURP expression, activates p-ERK/Ras-MAPK signaling, and enhances cell survival under imatinib treatment. The authors propose exosomal circ_0058493 and the circ_0058493/miR-548b-3p/U2SURP axis as potential biomarkers and therapeutic targets for imatinib-resistant CML."	0.5416
41274398	Cancer letters	2026	Mitochondria-located circRCP regulates redox homeostasis via stabilizing LRPPRC/SLIRP complex to promote bladder urothelial carcinoma tumorigenesis.	hsa_circ_0001789	circRCP	hsa_circ_RAB11FIP1		urothelial carcinoma of the bladder 	MONDO:0005611	bladder transitional cell carcinoma	up-regulated	RT-qPCR; Microarray	"circRCP is a human RAB11FIP1-derived circRNA that is frequently upregulated in UCB and predicts poor survival. It promotes UCB tumorigenesis by localizing predominantly to mitochondria and stabilizing the LRPPRC/SLIRP complex, thereby maintaining mitochondrial mRNA metabolism, oxidative phosphorylation, redox homeostasis and resistance to intrinsic apoptosis."	0.8981
41285321	Toxicology and applied pharmacology	2026	circSHOC1-SLC25A3 promotes 2-naphthylamine-induced DNA damage in bronchial epithelial cells via activation of oxidative stress.		circSHOC1 	hsa_circ_SHOC1	SHOC1	lung cancer 	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; RNA-seq	"circSHOC1 is a 2-NA-responsive circRNA derived from SHOC1 and up-regulated in 2-NA-treated human bronchial epithelial 16HBE cells. It promotes 2-NA-induced genotoxicity by interacting with mitochondrial SLC25A3, increasing ROS production and oxidative DNA damage. The study proposes a circSHOC1-SLC25A3-ROS axis relevant to tobacco-associated pulmonary carcinogenesis."	0.7986
41286534	Molecular neurobiology	2025	Functional Characterization and Expression Patterns of novel_circ_037817 in Schizophrenia Patients.		novel_circ_037817 	hsa_circ_IL13RA1	IL13RA1	schizophrenia 	MONDO:0005090	schizophrenia	up-regulated	RT-qPCR; RNA-seq	"novel_circ_037817 is a human IL13RA1-derived circRNA that is upregulated in PBMCs from schizophrenia patients. Its expression correlates with schizophrenia symptom severity, inflammatory and endocrine indicators, and SCZ risk, while functional knockdown experiments in an MK-801-induced SH-SY5Y injury model suggest that it promotes neuronal apoptosis and reduces cell viability, potentially through the mitochondrial apoptosis pathway involving Bcl-2/Bax imbalance."	0.7177
41311073	Nan fang yi ke da xue xue bao = Journal of Southern Medical University	2025	[circ_EPHB4 synergizes with YTHDF3 to promote glioma progression via m6A-dependent stabilization of Wnt3].	hsa_circ_0004018	circ_EPHB4 	hsa_circ_EPHB4	EPHB4	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR; RNA-seq; Microarray	"circ_EPHB4 is up-regulated in glioma tissues and glioma cell lines. It promotes glioma migration, invasion, EMT, tumor growth, and lung metastasis, at least partly by enhancing Wnt3 expression and cooperating with the m6A reader YTHDF3 to regulate Wnt3 mRNA stability. The study suggests the circ_EPHB4-YTHDF3-Wnt3 axis as a potential therapeutic target in glioma."	0.8244
41311088	Nan fang yi ke da xue xue bao = Journal of Southern Medical University	2025	[High-throughput circular RNA sequencing reveals tumor-specific high expression of hsa_circ_0001900 in Wilms tumor in association with poor prognosis].	hsa_circ_0001900	circCAMSAP1	hsa_circ_CAMSAP1	CAMSAP1	Wilms tumor 	MONDO:0006058	Wilms tumor	up-regulated	RT-qPCR; RNA-seq	"This study identified hsa_circ_0001900, also referred to as circCAMSAP1, as a tumor-specifically up-regulated circular RNA in Wilms tumor. Its expression was validated in clinical samples, correlated positively with tumor volume, showed diagnostic potential by ROC analysis, and was associated with a trend toward poorer recurrence-free survival."	0.7137
41314596	Life sciences	2026	circCNN2 drives endometrial cancer progression through ALKBH5/YTHDF2-mediated m6A regulation and miR-615-5p sponging.	hsa_circ_0048148	circCNN2	hsa_circ_CNN2	CNN2	endometrial cancer 	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR	"circCNN2 (hsa_circ_0048148), derived from CNN2, is up-regulated in endometrial cancer tissues and cell lines and functions as an oncogenic circRNA. Its expression is stabilized by ALKBH5-mediated m6A demethylation and opposed by YTHDF2-mediated degradation, while cytoplasmic circCNN2 sponges miR-615-5p to upregulate MYH14. Functionally, circCNN2 promotes proliferation, migration, invasion, EMT-associated changes, tumor growth and lung metastasis, and suppresses apoptosis, suggesting potential diagnostic, prognostic and therapeutic relevance."	0.8838
41320129	Archives of biochemistry and biophysics	2026	mmu_circ_0000684/hsa_circ_0067098 mediates renal tubular epithelial cells apoptosis to ischemia-reperfusion-induced acute kidney injury by targeting the mmu_miR_671-5p/ARID3B axis.	mmu_circ_0000684		mmu_circ_Zfp148	Zfp148	ischemia-reperfusion-induced acute kidney injury 	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR	"mmu_circ_0000684 is induced in mouse kidney tissue and BUMPT cells after I/R injury. It promotes renal tubular epithelial cell apoptosis by sponging miR-671-5p and increasing downstream ARID3B/Arid3b expression, while its knockdown attenuates apoptosis and ameliorates I/R-induced AKI in mice."	0.5997
41320129	Archives of biochemistry and biophysics	2026	mmu_circ_0000684/hsa_circ_0067098 mediates renal tubular epithelial cells apoptosis to ischemia-reperfusion-induced acute kidney injury by targeting the mmu_miR_671-5p/ARID3B axis.	hsa_circ_0067098				ischemia-reperfusion-induced acute kidney injury 	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR	"hsa_circ_0067098 is the human homolog of mmu_circ_0000684 and is up-regulated in HK-2 cells after I/R exposure. Its knockdown reduces I/R-induced apoptosis, likely through modulation of the miR-671-5p/ARID3B axis, and the authors propose it as a potential therapeutic target for ischemic AKI."	0.3957
41335532	Journal of physiology and pharmacology : an official journal of the Polish Physiological Society	2025	Circular RNA eukaryotic translation initiation factor-6 motivates aerobic glycolysis and angiogenesis in triple negative breast cancer via performing as the competing endogenous RNA of microRNA-296-3p to target metallothionein 2A.			hsa_circ_EIF6	EIF6	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"circEIF6 is upregulated in TNBC tissues and MDA-MB-231 cells and is associated with advanced clinicopathological features and poor overall survival. Mechanistically, circEIF6 acts as a ceRNA for miR-296-3p to regulate MT2A, promoting aerobic glycolysis, angiogenesis, proliferation and malignant progression, suggesting potential diagnostic and therapeutic value in TNBC."	0.8709
41340590	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2025	Identifying Circ-RNF216 as a Regulator of Renal Tubular Epithelial Cell Proliferation Via the TGF-beta1/Smad3-Mediated Pathway in Chronic Kidney Disease.		circ-RNF216	mmu_circ_Rnf216	Rnf216/Triad3	chronic kidney disease 	MONDO:0005300	chronic kidney disease	up-regulated	RT-qPCR; ISH; RNA-seq	"circ-RNF216 is a mouse Rnf216/Triad3-derived circRNA that is significantly up-regulated in UUO kidney models of chronic kidney disease. The study shows that TGF-beta1 induces circ-RNF216 in a Smad3-dependent manner, and circ-RNF216 promotes TGF-beta1-induced EMT, tubular epithelial cell migration, and renal fibrosis. Knockdown of circ-RNF216 alters mRNA expression profiles and affects TGF-beta receptor signaling, epithelial cell proliferation, Wnt/Hippo-related pathways, and inflammation-associated signaling."	0.6862
41342162	Kidney research and clinical practice	2025	Hsa_circRNA_101015 and hsa_circRNA_104310 as novel biomarkers of childhood steroid-resistant nephrotic syndrome.	hsa_circ_0000378	hsa_circRNA_101015 	hsa_circ_LRP6	LRP6	childhood steroid-resistant nephrotic syndrome 	MONDO:0044765	steroid-resistant nephrotic syndrome	down-regulated	RT-qPCR; Microarray	hsa_circRNA_101015 is down-regulated in PBMCs of children with SRNS compared with SSNS and was validated by qRT-PCR. It shows strong diagnostic performance for distinguishing SRNS from SSNS and is proposed to participate in NS pathogenesis through a predicted circRNA-miRNA-mRNA network involving miRNAs such as hsa-mir-499a-3p and inflammatory/NF-kappaB-related targets.	0.5963
41342162	Kidney research and clinical practice	2025	Hsa_circRNA_101015 and hsa_circRNA_104310 as novel biomarkers of childhood steroid-resistant nephrotic syndrome.		hsa_circRNA_104310 			childhood steroid-resistant nephrotic syndrome 	MONDO:0044765	steroid-resistant nephrotic syndrome	down-regulated	RT-qPCR; Microarray	hsa_circRNA_104310 is down-regulated in PBMCs of children with SRNS compared with SSNS and was validated by qRT-PCR. It has diagnostic value for distinguishing SRNS from SSNS and is proposed to participate in NS pathogenesis through a predicted circRNA-miRNA-mRNA network involving miRNAs such as hsa-mir-499a-3p and NFKBIA/NF-kappaB-related inflammatory signaling.	0.5963
41344046	"Colloids and surfaces. B, Biointerfaces"	2026	Exosome circ_0076611-mediated macrophage M2 polarization to improve triple-negative breast cancer metastasis and the intervention of baicalin nano prodrugs.	hsa_circ_0076611	circ_0076611 			triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"In this study, exosomal circ_0076611 functions as a TRAF3IP2-regulated cargo released by TNBC cells. After uptake by macrophages, circ_0076611 activates STAT6 signaling to promote M2 TAM polarization, thereby enhancing TNBC invasion, EMT-like marker changes, tumor growth, and lung metastasis. The baicalin nano prodrug TBSP suppresses this TRAF3IP2-exosomal circ_0076611 axis and reduces metastasis."	0.6285
41351372	"Cellular and molecular biology (Noisy-le-Grand, France)"	2025	CircFOXK2 induces non-small cell lung cancer tumorigenesis through the miR-328-5p/PKP3 axis.		circFOXK2	hsa_circ_FOXK2	FOXK2	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circFOXK2 is up-regulated in NSCLC tissues and cell lines. It promotes NSCLC cell proliferation, migration, invasion, and tumorigenic progression in vitro by sponging miR-328-5p and indirectly increasing PKP3 expression. The circFOXK2/miR-328-5p/PKP3 axis is proposed as a potential therapeutic target for NSCLC."	0.6521
41351835	Cell reports	2025	circATF6 triggers calcium overload to synergize with EGFR-TKI in non-small cell lung cancer via modulation of proteostasis.		circATF6 	hsa_circ_ATF6	ATF6	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	"circATF6 is a human ATF6-derived circRNA that is selectively downregulated in EGFR-TKI-induced NSCLC DTP cells through ADAR1-mediated splicing regulation. Restoring or delivering circATF6 sensitizes DTP cells and tumors to osimertinib by binding BiP/GRP78, blocking adaptive UPR signaling, disrupting proteostasis and ER calcium homeostasis, and inducing calcium overload-mediated apoptosis."	0.8878
41361078	Oncogene	2026	circSETD3 confers radiotherapy resistance in nasopharyngeal carcinoma by attenuating ER stress-induced autophagy and apoptosis via PDIA6 upregulation.		circSETD3	hsa_circ_SETD3	SETD3	Nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; ISH	"circSETD3 acts as a pro-radioresistance circRNA in nasopharyngeal carcinoma. It binds the 3¡äUTR of PDIA6 mRNA to enhance PDIA6 mRNA stability and protein expression, thereby maintaining ER proteostasis, suppressing UPR/ER stress, and inhibiting radiation-induced autophagy and apoptosis. The circSETD3-PDIA6 axis is proposed as a potential therapeutic target and predictive biomarker for radiotherapy response."	0.8325
41364173	Journal of physiology and pharmacology : an official journal of the Polish Physiological Society	2025	Circular RNA collagen type V alpha 1 exerts a carcinogenic role in renal cell carcinoma via modulating microRNA-3940-3p/Karyopherin alpha2 axis.		circular RNA collagen Valpha1 chain 	hsa_circ_COL5A1	COL5A1	renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR	"CircCOL5A1 is up-regulated in RCC tissues and cell lines and is associated with poor prognosis, diagnostic potential, and aggressive clinicopathological features. Mechanistically, cytoplasmic circCOL5A1 sponges miR-3940-3p to increase KPNA2 expression, thereby promoting RCC cell proliferation, migration, invasion, EMT and glycolysis while inhibiting apoptosis."	0.8595
41376162	Molecular therapy : the journal of the American Society of Gene Therapy	2026	Methylated circPTK2 as a driver of fibroblast activation in pulmonary fibrosis.	hsa_circ_0002483	circPTK2 	hsa_circ_PTK2	PTK2	pulmonary fibrosis 	MONDO:0002771	pulmonary fibrosis	up-regulated	RT-qPCR; ISH; RNA-seq	"circPTK2, especially its m6A-modified form circPTK2-m +, is upregulated in pulmonary fibrosis and acts as a fibroblast-specific profibrotic driver. METTL3/RBMX-dependent m6A regulation promotes its generation, EIF4A3 supports its cytoplasmic export, and cytoplasmic circPTK2-m + sponges miR-484 and miR-125a-3p to increase YAP1 and FYN, activate STAT3 signaling, and enhance fibroblast activation and fibrosis. Silencing circPTK2-m + alleviates BLM-induced pulmonary fibrosis, supporting its therapeutic relevance."	0.886
41376162	Molecular therapy : the journal of the American Society of Gene Therapy	2026	Methylated circPTK2 as a driver of fibroblast activation in pulmonary fibrosis.	mmu_circ_0002483	circPTK2 	mmu_circ_PTK2	PTK2	pulmonary fibrosis 	MONDO:0002771	pulmonary fibrosis	up-regulated	RT-qPCR; ISH; RNA-seq	"circPTK2, especially its m6A-modified form circPTK2-m +, is upregulated in pulmonary fibrosis and acts as a fibroblast-specific profibrotic driver. METTL3/RBMX-dependent m6A regulation promotes its generation, EIF4A3 supports its cytoplasmic export, and cytoplasmic circPTK2-m + sponges miR-484 and miR-125a-3p to increase YAP1 and FYN, activate STAT3 signaling, and enhance fibroblast activation and fibrosis. Silencing circPTK2-m + alleviates BLM-induced pulmonary fibrosis, supporting its therapeutic relevance."	0.886
41376216	Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan	2025	Electroacupuncture alleviates type 2 diabetes mellitus by promoting plasma-derived exosomal circular RNA of enhancer of zeste homolog 1 expression.		CircEZH1 	mmu_circ_EZH1	EZH1	type 2 diabetes mellitus 	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RT-qPCR	"CircEZH1 is a mouse plasma-derived exosomal circRNA that is down-regulated in T2DM model mice and up-regulated by electroacupuncture treatment. The study indicates that CircEZH1 supports pancreatic beta-cell viability, inhibits apoptosis, contributes to insulin expression and secretion, and helps maintain insulin sensitivity and glucose tolerance, suggesting therapeutic relevance for T2DM."	0.4236
41380930	Archives of biochemistry and biophysics	2026	circCacna1c modulates osteogenic differentiation of BMSCs via miR-7669-3p/Ciart axis in osteoporosis.	mmu_circ_0001511	circCacna1c	mmu_circ_Cacna1c	Cacna1c	osteoporosis 	MONDO:0005298	osteoporosis	down-regulated	RT-qPCR; Microarray	"circCacna1c is a mouse circRNA derived from Cacna1c that is downregulated in BMSCs from OVX osteoporosis mice and upregulated during osteogenic differentiation. It promotes BMSC osteogenesis by acting as a cytoplasmic ceRNA sponge for miR-7669-3p, thereby increasing Ciart expression and osteogenic markers. The circCacna1c/miR-7669-3p/Ciart axis is proposed as a potential therapeutic target for osteoporosis."	0.749
41384925	Journal of Alzheimer's disease : JAD	2026	Hsa_circ_0015335 as a potential biomarker for cognitive decline in type 2 diabetes mellitus.	hsa_circ_0015335				type 2 diabetes mellitus-related mild cognitive impairment 	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RT-qPCR	"hsa_circ_0015335 is down-regulated in whole blood from T2DM-MCI patients compared with T2DM-NC controls. Lower hsa_circ_0015335 levels are associated with poorer cognitive function and higher insulin-resistance-related metabolic markers, while higher baseline levels predict slower cognitive decline over 1.5 years. The study supports hsa_circ_0015335 as a potential peripheral biomarker for T2DM-MCI and suggests a possible mechanism involving TyG index-related glucose metabolism dysregulation."	0.4758
41388867	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2025	"Transcriptomic Profiling of mRNAs, circRNAs, and lncRNAs in Mouse Liver at the Early Stage of Echinococcus multilocularis Infection."	mmu_circ_0008646				Alveolar echinococcosis 	MONDO:0017282	alveolar echinococcosis	dysregulated	RT-qPCR; Microarray	"mmu_circ_0008646 is highlighted as a circRNA in the AE-related ceRNA network. It interacts with several miRNAs, especially miR-574-5p, which is implicated in macrophage polarization and inflammatory responses via the NF-kappaB pathway."	0.5008
41388867	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2025	"Transcriptomic Profiling of mRNAs, circRNAs, and lncRNAs in Mouse Liver at the Early Stage of Echinococcus multilocularis Infection."	mmu_circ_0009988				Alveolar echinococcosis 	MONDO:0017282	alveolar echinococcosis	dysregulated	RT-qPCR; Microarray	mmu_circ_0009988 was validated by RT-qPCR in infected mouse liver samples and was included in the circRNA-miRNA-mRNA ceRNA network. The paper suggests that it may have broad regulatory relevance through association with multiple miRNAs.	0.4474
41388867	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2025	"Transcriptomic Profiling of mRNAs, circRNAs, and lncRNAs in Mouse Liver at the Early Stage of Echinococcus multilocularis Infection."	mmu_circ_0001342				Alveolar echinococcosis 	MONDO:0017282	alveolar echinococcosis	dysregulated	Microarray	mmu_circ_0001342 was identified from microarray-based transcriptome profiling as a key circRNA in a co-expression network with immune-related mRNAs. The study suggests it may contribute to modulation of host immune responses during early E. multilocularis infection.	0.3963
41388867	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2025	"Transcriptomic Profiling of mRNAs, circRNAs, and lncRNAs in Mouse Liver at the Early Stage of Echinococcus multilocularis Infection."	mmu_circ_0014062				Alveolar echinococcosis 	MONDO:0017282	alveolar echinococcosis	dysregulated	Microarray	"mmu_ circ_0014062 was identified as a key circRNA in a co-expression network with mRNAs in infected mouse liver. The study suggests it may influence host immune responses in early E. multilocularis infection, but experimental validation beyond microarray and network analysis was not reported for this specific circRNA."	0.3963
41388867	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2025	"Transcriptomic Profiling of mRNAs, circRNAs, and lncRNAs in Mouse Liver at the Early Stage of Echinococcus multilocularis Infection."	mmu_circ_0012614				Alveolar echinococcosis 	MONDO:0017282	alveolar echinococcosis	dysregulated	Microarray	"mmu_circ_0012614 was identified as a key circRNA in a co-expression network with mRNAs in infected mouse liver. It may contribute to the regulation of host immune responses during early E. multilocularis infection, but no RT-qPCR validation specific to this circRNA was reported."	0.3963
41390174	Gut	2026	Fibroblast pentose phosphate pathway activation upon decreased circPLCE1 exacerbates intestinal fibrosis in Crohn's disease.		circPLCE1	hsa_circ_PLCE1	PLCE1	intestinal fibrosis in Crohn's disease 	MONDO:0005011	Crohn disease	down-regulated	RT-qPCR; ISH	"circPLCE1 is downregulated in fibroblasts from strictured intestinal segments of patients with Crohn's disease and in DSS-induced fibrotic mice. It suppresses intestinal fibrosis by directly binding XYLB and competitively inhibiting XYLB enzymatic activity, thereby reducing Xu5P accumulation, PPP activation, glycolysis, NADPH production and ECM/collagen deposition. Its reduced expression correlates with fibrosis severity metrics, supporting potential biomarker and therapeutic relevance."	0.8405
41390174	Gut	2026	Fibroblast pentose phosphate pathway activation upon decreased circPLCE1 exacerbates intestinal fibrosis in Crohn's disease.			mmu_circ_Plce1	Plce1	intestinal fibrosis in Crohn's disease 	MONDO:0005011	Crohn disease	down-regulated	RT-qPCR; ISH	"circPLCE1 is downregulated in fibroblasts from strictured intestinal segments of patients with Crohn's disease and in DSS-induced fibrotic mice. It suppresses intestinal fibrosis by directly binding XYLB and competitively inhibiting XYLB enzymatic activity, thereby reducing Xu5P accumulation, PPP activation, glycolysis, NADPH production and ECM/collagen deposition. Its reduced expression correlates with fibrosis severity metrics, supporting potential biomarker and therapeutic relevance."	0.8405
41392551	Turk psikiyatri dergisi = Turkish journal of psychiatry	2025	Peripheral Circular RNA Expression Levels in Schizophrenia and Schizoaffective Disorder: Associations with Clinical Characteristics and Behavioral Phenotypes.		chr3_196488683			schizophrenia 	MONDO:0005090	schizophrenia	up-regulated	RT-qPCR; RNA-seq; Microarray	"chr3_196488683 was measured in peripheral blood from patients with schizophrenia or schizoaffective disorder. Its level was higher in patients with non-suicidal self-injurious behavior and homicidal behavior, and it also showed a weak positive correlation with anxiety score, suggesting potential biomarker relevance for behavioral risk profiles."	0.348
41392551	Turk psikiyatri dergisi = Turkish journal of psychiatry	2025	Peripheral Circular RNA Expression Levels in Schizophrenia and Schizoaffective Disorder: Associations with Clinical Characteristics and Behavioral Phenotypes.		chr5_69175537			schizophrenia 	MONDO:0005090	schizophrenia	up-regulated	RT-qPCR; RNA-seq; Microarray	"chr5_69175537 was measured in peripheral blood from patients with schizophrenia or schizoaffective disorder. Its level was higher in patients with non-suicidal self-injurious behavior and homicidal behavior, suggesting possible biomarker relevance for behavioral disinhibition, aggression, and harm-related risk profiles."	0.348
41392551	Turk psikiyatri dergisi = Turkish journal of psychiatry	2025	Peripheral Circular RNA Expression Levels in Schizophrenia and Schizoaffective Disorder: Associations with Clinical Characteristics and Behavioral Phenotypes.	hsa_circ_0084021				schizophrenia 	MONDO:0005090	schizophrenia	up-regulated	RT-qPCR; RNA-seq; Microarray	"hsa_circ_0084021 was measured in peripheral blood from patients with schizophrenia or schizoaffective disorder. Its level was higher in patients with non-suicidal self-injurious behavior, but it was not significantly different in the homicidal behavior comparison, suggesting a more limited association with self-harm-related behavioral risk."	0.348
41397666	Experimental cell research	2026	Tumor cell exosome circ-0023919 promotes EMT through the miR-197-5p/ICAM5 axis and enhances the drug resistance of colorectal cancer to 5-fu.	hsa_circ_0023919	circ-0023919 	hsa_circ_PICALM	PICALM	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"Tumor cell-derived exosomal circ-0023919 is upregulated in 5-Fu-resistant colorectal cancer cells and exosomes and is associated with poor prognosis and diagnostic value for 5-Fu resistance. Functionally, circ-0023919 promotes CRC cell migration, invasion, tumor growth, EMT, stemness, drug efflux, and chemoresistance. Mechanistically, it acts as a ceRNA sponge for miR-197-5p to increase ICAM5 expression, thereby promoting EMT-mediated 5-Fu resistance."	0.898
41405748	Odontology	2025	Circ_0043582 promotes dental pulp cell injury via miR-940/TRAF3/NF-kappaB axis in pulpitis.	hsa_circ_0043582	circ_0043582			pulpitis 	MONDO:0006937	pulpitis	up-regulated	RT-qPCR	"circ_0043582 is up-regulated in pulpitis tissues and LPS-treated HDPCs. Functionally, it aggravates LPS-induced HDPC injury and inflammation, while its knockdown alleviates proliferation inhibition, apoptosis, oxidative stress, inflammatory cytokine release, and M1 macrophage polarization. Mechanistically, circ_0043582 sponges miR-940 to regulate TRAF3 and promote NF-kappaB signaling activation."	0.8118
41407226	International journal of biological macromolecules	2026	circSCYL2 antagonizes hnRNPA2B1-mediated m6A-chromatin crosstalk to promote ferroptosis and inhibit metastasis of breast cancer to brain.		circSCYL2	hsa_circ_SCYL2	SCYL2	breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	"circSCYL2 is downregulated in breast cancer cells from brain metastases. Its overexpression suppresses brain metastatic colonization and BBB crossing by promoting ACSL4-dependent ferroptosis. Mechanistically, circSCYL2 binds hnRNPA2B1 and disrupts m6A-dependent hnRNPA2B1/SETDB1-mediated H3K9me3 repression at the ACSL4 promoter, thereby enhancing ACSL4 transcription."	0.7233
41408962	Biotechnology and applied biochemistry	2025	Circ_0105487 Promotes the Metastasis of Triple-Negative Breast Cancer via Epithelial-Mesenchymal Transition.	hsa_circ_0105487	circ_0105487 			breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0105487/circ_0105487 is up-regulated in TNBC tumor tissues and TNBC cell lines. It promotes TNBC cell growth, migration, invasion, and lung metastasis, at least partly through EMT-associated induction of N-cadherin. The study proposes hsa_circ_0105487 as a potential diagnostic biomarker and therapeutic target for TNBC."	0.6921
41410555	Molecular cancer research : MCR	2026	circNEIL3 Stabilizes SPI1 mRNA and Promotes Glioma Progression and Temozolomide Resistance by Binding to U2AF2.		circNEIL3	hsa_circ_NEIL3	NEIL3	glioma 	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circNEIL3 is up-regulated in glioma and is higher in TMZ-resistant tissues and cells. Functionally, circNEIL3 promotes proliferation and colony formation, suppresses apoptosis, and confers TMZ resistance in glioma cells. Mechanistically, circNEIL3 binds the RNA-binding protein U2AF2 to stabilize SPI1 mRNA expression."	0.8073
41419018	Life sciences	2026	Coxsackievirus B3 suppresses oral squamous cell carcinoma by inducing ferroptosis through the circ_0010074/miR-214-3p/GPX4 pathway.	hsa_circ_0010074	circ_0010074 	hsa_circ_PLEKHM2	PLEKHM2	oral squamous cell carcinoma 	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	"In OSCC models, CVB3 downregulates hsa_circ_0010074/circ_0010074, which releases miR-214-3p to suppress GPX4 and promote ferroptosis. circ_0010074 itself functions as a cytoplasmic miR-214-3p sponge and has an anti-ferroptotic, cell-preserving role by sustaining GPX4 expression."	0.7435
41421230	International immunopharmacology	2026	Mmu_Circ_0001022/hsa_Circ_0056869-miRNA-92a-2-5p/SKI axis suppressed the progression of sepsis-associated acute kidney injury.	mmu_circ_0001022				sepsis-associated acute kidney injury 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR; ISH	"mmu_circ_0001022 is upregulated in LPS-treated BUMPT cells and CLP-induced mouse kidneys. It protects against SA-AKI by acting as a ceRNA for miRNA-92a-2-5p, increasing SKI expression and suppressing renal tubular cell apoptosis."	0.5997
41421230	International immunopharmacology	2026	Mmu_Circ_0001022/hsa_Circ_0056869-miRNA-92a-2-5p/SKI axis suppressed the progression of sepsis-associated acute kidney injury.	hsa_circ_0056869				sepsis-associated acute kidney injury 	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR	hsa_circ_0056869 is the human homolog of mmu_circ_0001022 and is upregulated in LPS-treated HK-2 cells and in plasma from SA-AKI patients. It suppresses HK-2 cell apoptosis through the miRNA-92a-2-5p/SKI axis and shows diagnostic potential for distinguishing SA-AKI from septic non-AKI.	0.6304
41421287	Phytomedicine : international journal of phytotherapy and phytopharmacology	2026	Muskardia inhibits proliferation and migration of human coronary artery smooth muscle cells by regulating SLC7A11 mRNA stability via the hsa_circTEX10-PCBP2 Axis.		hsa_circTEX10 	hsa_circ_TEX10	TEX10	coronary artery disease 	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR; RNA-seq	"hsa_circTEX10 is up-regulated in ox-LDL-induced HCASMCs and in PBMCs from CAD patients. It promotes HCASMC proliferation and migration by binding PCBP2, inhibiting PCBP2 ubiquitination-mediated degradation, and increasing SLC7A11 mRNA stability. Clinically, elevated hsa_circTEX10 is associated with CAD risk, reduced LCX-QFR, and potential diagnostic biomarker value."	0.8931
41439406	The Kaohsiung journal of medical sciences	2025	Circ_0006174 Drives Triple Negative Breast Cancer Progression and Immune Escape Through Regulating miR-3139/PD-L1 Axis.	hsa_circ_0006174		hsa_circ_RAD23B	RAD23B	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0006174 is upregulated in TNBC tissues and cell lines and high expression is linked to poor prognosis. METTL3-mediated m6A methylation regulates circ_0006174, which sponges miR-3139 to increase PD-L1 expression, thereby promoting TNBC proliferation, invasion, tumor growth, and immune escape."	0.8868
41439564	Biology of reproduction	2026	Recombinant human granulocyte colony-stimulating factor improves implantation partly by downregulating Hsa_circ_0001550_.	hsa_circ_0001550		hsa_circ_RARS	RARS	recurrent implantation failure 	MONDO:0005047	infertility disorder	up-regulated	RT-qPCR; Microarray	"This study identifies hsa circ 0001550 as a human circRNA derived from RARS and a negative regulator of endometrial receptivity, embryo adhesion, and embryo implantation. It is reported as upregulated in RIF-related samples, and functional overexpression/knockdown experiments show that it suppresses adhesion and implantation partly through downregulation of HOXA10 and LIF. rhG-CSF improves implantation partly by downregulating hsa circ 0001550, suggesting potential biomarker and therapeutic relevance in infertility and implantation failure."	0.4732
41443149	Molecular immunology	2026	Silence of circPLK1 inhibits NSCLC progression by regulating the miR-1294/SLC16A9 axis.		circPLK1 	hsa_circ_PLK1	PLK1	Non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circPLK1 is up-regulated in NSCLC cells and functions as an oncogenic circRNA. Its knockdown suppresses proliferation, viability, migration, invasion and xenograft tumor growth while promoting apoptosis. Mechanistically, circPLK1 sponges miR-1294 to promote SLC16A9 expression, forming a circPLK1/miR-1294/SLC16A9 regulatory axis with potential therapeutic and biomarker relevance."	0.5634
41454177	In vitro cellular & developmental biology. Animal	2026	CircFoxo3 knockdown inhibit gastric cancer progression by regulating Foxo3.		CircFoxo3 	hsa_circ_FOXO3	FoxO3	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"CircFoxo3 is upregulated in gastric cancer tissues and cell lines and functions as an oncogenic circRNA. Its knockdown suppresses GC cell proliferation, migration, and xenograft tumor growth, at least partly by decreasing Foxo3/FOXO3 mRNA and protein expression. The study suggests circFoxo3 may be a therapeutic target and potential biomarker in gastric cancer."	0.6194
41455521	Genomics	2026	Fusobacterium nucleatum exacerbates atherosclerosis progression via ceRNA network-mediated epigenetic reprogramming.		circRNA5047 			atherosclerosis 	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR; RNA-seq	"In F. nucleatum-infected ApoE -/- mice, circRNA5047 is identified as a key circRNA in an atherosclerosis-related ceRNA network. It is proposed to sponge miR-18a-3p and miR-669f-3p, thereby derepressing Cflar and Itpr1 and contributing to dysregulated autophagy, advanced plaque formation, and plaque instability."	0.3684
41456226	Molecular biology reports	2025	circ-Ttc3 alleviates LPS-induced neuronal injury via stabilizing RBFOX1 to inhibit inflammation and oxidative stress.		circ-Ttc3	rno_circ_Ttc3	Ttc3	spinal cord injury 	MONDO:0043797	spinal cord injury	down-regulated	RT-qPCR	"circ-Ttc3 is downregulated in LPS-induced PC12 neuronal injury and acts as a protective circRNA in an in vitro SCI-related injury model. Its overexpression improves cell viability and suppresses apoptosis, inflammatory cytokine production, and oxidative stress by directly binding and stabilizing the RNA-binding protein RBFOX1."	0.6004
41456348	Journal of agricultural and food chemistry	2026	Pelargonidin-3-O-Glucoside Restores Nitric Oxide Production via Interaction with circHMGCS1 to Ameliorate Endothelial Dysfunction.		circHMGCS1	hsa_circ_HMGCS1	HMGCS1	type 2 diabetes mellitus 	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RT-qPCR	"circHMGCS1 is investigated as a pathogenic circRNA in T2DM-associated vascular endothelial dysfunction. Pg3G suppresses and directly interacts with circHMGCS1, restoring the miR-4521/ARG1 axis and improving NO bioavailability, eNOS activity, oxidative stress, and inflammatory adhesion molecule expression. circHMGCS1 knockdown mimics Pg3G protection, while circHMGCS1 overexpression counteracts it."	0.4376
41468248	Journal of biochemical and molecular toxicology	2026	CircANKRD36 Knockdown Inhibits M1 Polarization and Inflammatory Response via miR-498/TXNRD1 in LPS-Stimulated Macrophages Under High Glucose Conditions.		circANKRD36 	hsa_circ_ANKRD36	ANKRD36	diabetes 	MONDO:0005015	diabetes mellitus	up-regulated	RT-qPCR	"circANKRD36 is up-regulated in LPS-stimulated macrophages under high glucose conditions and contributes to excessive M1 polarization and inflammatory responses. Its knockdown upregulates miR-498, decreases TXNRD1 expression, and reduces inflammatory markers including IL-1beta, TNF-alpha and iNOS, suggesting a circANKRD36/miR-498/TXNRD1 regulatory mechanism relevant to diabetic complications."	0.7536
41468427	Proceedings of the National Academy of Sciences of the United States of America	2026	Circular RNA-based therapy targeting metabolic vulnerability of fatty acid synthesis overcomes castration-resistant prostate cancer.	hsa_circ_0009096	circUTRN	hsa_circ_UTRN	UTRN	prostate cancer 	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; RNA-seq	"circUTRN is a UTRN-derived human circRNA that is downregulated in prostate cancer tissues and negatively regulated by AR/EZH2-mediated repression. It functions as a tumor-suppressive circRNA by binding ACC1, disrupting ACC1 polymerization and de novo fatty acid synthesis, thereby inhibiting proliferation and promoting apoptosis. PSMA-targeted nanoparticle delivery of circUTRN showed therapeutic benefit in CRPC and enzalutamide-resistant CRPC xenograft models."	0.8902
41468540	Folia biologica	2025	Hsa_circ_0000977 Sponges miR-338-3p to Drive Cholangiocarcinoma Progression and Predict Poor Prognosis.	hsa_circ_0000977				cholangiocarcinoma 	MONDO:0019087	cholangiocarcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000977 is up-regulated in CCA tumour tissues and high expression predicts poorer survival. It promotes CCA cell proliferation and migration by sponging miR-338-3p and relieving repression of ETS1, forming the hsa_circ_0000977/miR-338-3p/ETS1 oncogenic axis."	0.7283
41474129	Genetic testing and molecular biomarkers	2025	Hsa_circ_0009910/hsa-miR-145-5p/IFNB1 Axis Potential Role in the Immunopathogenesis of COVID-19 Disease.	hsa_circ_0009910		hsa_circ_MFN2	MFN2	COVID-19 	MONDO:0100096	COVID-19	up-regulated	RT-qPCR	hsa_circ_0009910 was up-regulated in PBMCs from symptomatic and nonsymptomatic COVID-19 patients compared with negative controls. The study suggests that hsa_circ_0009910 may act through a hsa-miR-145-5p/IFNB1 ceRNA axis involved in COVID-19 immune responses and may have biomarker and therapeutic-target potential.	0.459
41474375	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2026	Upregulation of CircXPO1 Promotes the Progression of Gastric Cancer and May Serve as a Potential Auxiliary Biomarker for Its Diagnosis.	hsa_circ_0001017	circXPO1	hsa_circ_XPO1	XPO1	gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"circXPO1 (hsa_circ_0001017), derived from XPO1, is up-regulated in gastric cancer tissues, plasma, and cell lines. It promotes GC cell proliferation, migration, invasion, and metastasis while inhibiting apoptosis, and it binds miR-1248 as a miRNA sponge. Plasma circXPO1 shows diagnostic value for distinguishing GC patients from healthy donors and may support dynamic monitoring after surgery."	0.8407
41475283	International immunopharmacology	2026	circSERINC3 facilitates STAT3-CDK5 crosstalk to orchestrate immunosuppressive microenvironments in pancreatic Cancer.	hsa_circ_0002615	circSERINC3	hsa_circ_SERINC3	SERINC3	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circSERINC3 is an upregulated PDAC-associated circRNA that correlates with advanced disease and poor prognosis. It functions as a cytoplasmic scaffold that bridges CDK5 and STAT3, enhances STAT3 Ser727 phosphorylation, activates JAK/STAT3 signaling, upregulates PD-L1, and suppresses CD8+ T-cell antitumor activity, thereby promoting an immunosuppressive tumor microenvironment."	0.8913
41481139	"Cell cycle (Georgetown, Tex.)"	2026	Circular RNA circ_0050102 promotes colorectal cancer progression via modulation of the miR-3622a-3p/BIRC5 signaling pathway.	hsa_circ_0011773	circ_0011773			colorectal cancer 	MONDO:0005575	colorectal cancer	dysregulated	Microarray	"circ_0011773 was identified as a significantly differentially expressed circRNA in CRC tumor samples versus normal controls using the GSE172229 microarray dataset. It showed limited diagnostic performance with an AUC of 0.68, and no functional or mechanistic validation was reported."	0.348
41481139	"Cell cycle (Georgetown, Tex.)"	2026	Circular RNA circ_0050102 promotes colorectal cancer progression via modulation of the miR-3622a-3p/BIRC5 signaling pathway.	hsa_circ_0050102	circ_0050102			colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	Microarray	"circ_0050102 is upregulated in CRC and shows diagnostic potential with an AUC of 0.958. Functionally, circ_0050102 promotes CRC cell viability, proliferation, invasion, migration, cell cycle progression, and xenograft tumor growth while suppressing apoptosis. Mechanistically, it acts through a circ_0050102/miR-3622a-3p/BIRC5 regulatory axis consistent with a miRNA sponge/ceRNA mechanism."	0.7955
41481139	"Cell cycle (Georgetown, Tex.)"	2026	Circular RNA circ_0050102 promotes colorectal cancer progression via modulation of the miR-3622a-3p/BIRC5 signaling pathway.	hsa_circ_0122790	circ_0122790			colorectal cancer 	MONDO:0005575	colorectal cancer	dysregulated	Microarray	"circ_0122790 was identified as a significantly differentially expressed circRNA in CRC tumor samples versus normal controls using the GSE172229 microarray dataset. It showed potential diagnostic relevance with an AUC of 0.868, but no functional or mechanistic validation was reported."	0.348
41483083	Clinical rheumatology	2026	Circ_0004662 promotes lipopolysaccharide-induced osteoarthritis by targeting the miR-450b-5p/TCF4 axis.	hsa_circ_0004662	circ_0004662 	hsa_circ_SOD2	SOD2	osteoarthritis 	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; Microarray	circ_0004662 is upregulated in OA cartilage tissues and LPS-stimulated human chondrocytes. It promotes inflammatory chondrocyte injury by acting as a sponge for miR-450b-5p and increasing TCF4 expression; its knockdown improves cell viability and reduces apoptosis and inflammatory cytokine secretion. The study also suggests circ_0004662 may have diagnostic biomarker potential for OA.	0.7756
41487094	Circulation research	2026	CircZBTB44-Encoded Peptide ZBTB44-342aa Alleviates Aortic Valve Calcification Via cGAS-STING Inhibition.	hsa_circ_0002484	circZBTB44	hsa_circ_ZBTB44	ZBTB44	calcific aortic valve disease 	MONDO:0003803	aortic valve disorder	down-regulated	RT-qPCR; Northern Blot; ISH; RNA-seq	"circZBTB44 is downregulated in human calcified aortic valves and peripheral blood from CAVD patients. It encodes the peptide ZBTB44-342aa through an m6A-dependent mechanism, and this peptide binds IGF2BP3 to stabilize CAMK1, preserve mitochondrial integrity, reduce mtDNA leakage, and inhibit cGAS-STING/NF-kappaB-driven osteogenic and inflammatory responses. Functionally, circZBTB44 overexpression alleviates aortic valve calcification in vivo and suppresses osteogenic differentiation of HAVICs in vitro, suggesting therapeutic and diagnostic potential in CAVD."	0.8778
41489864	Advances in clinical and experimental medicine : official organ Wroclaw Medical University	2026	ERalpha inhibits the progression of hepatocellular carcinoma by regulating the circRNA/miRNA/SMADs network.	hsa_circ_0004913				hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"In this study, hsa_circ_0004913 was down-regulated in the HCC cell line MHCC97H compared with normal QSG7701 liver cells. ERalpha/ESR1 was shown to bind the hsa_circ_0004913 promoter and increase its expression, while hsa_circ_0004913 interacted with hsa-miR-96-5p within the proposed ERalpha/hsa_circ_0004913/hsa-miR-96-5p/SMAD7 regulatory axis. The authors propose that this circRNA/miRNA/SMADs network contributes to suppression of HCC progression."	0.5608
41490595	Experimental cell research	2026	The circ-GLG1/miR-346/KCNJ9 axis drives malignant progression of bladder cancer by modulating KCNJ9 expression.	hsa_circ_0040457	circ-GLG1	hsa_circ_GLG1	GLG1	bladder cancer 	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circ-GLG1 is an up-regulated GLG1-derived circRNA in bladder cancer and is associated with advanced pTNM stage and poor overall survival. Functionally, it promotes malignant phenotypes and xenograft tumor growth. Mechanistically, circ-GLG1 sponges miR-346 to derepress KCNJ9, leading to activation of TGF-beta/SMAD, PI3K/AKT, and MAPK signaling pathways."	0.8618
41494978	"APMIS : acta pathologica, microbiologica, et immunologica Scandinavica"	2026	Identification of Metastasis-Associated circRNA-miRNA-mRNA Network Reveals Novel Biomarkers and Therapy Strategies for Esophageal Cancer.	hsa_circ_0007551	circ_0007551	hsa_circ_NDST1	NDST1	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"hsa_circ_0007551 is reported to be upregulated in ESCC tissues and cells, especially metastatic ESCC contexts. The study proposes a hsa_circ_0007551/miR-493-5p/CXCL8-BMP2 ceRNA axis that may promote ESCC metastasis and serve as a biomarker or therapeutic target."	0.5545
41494978	"APMIS : acta pathologica, microbiologica, et immunologica Scandinavica"	2026	Identification of Metastasis-Associated circRNA-miRNA-mRNA Network Reveals Novel Biomarkers and Therapy Strategies for Esophageal Cancer.	hsa_circ_0005777	cir-cRGNEF			esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	dysregulated	Microarray	"hsa_circ_0005777 was one of six overlapping DEcircRNAs identified from ESCC GEO microarray datasets. It was incorporated into a predicted circRNA-miRNA-mRNA ceRNA network linked to ESCC metastasis, but no circRNA-specific RT-qPCR or functional validation was reported."	0.1768
41494978	"APMIS : acta pathologica, microbiologica, et immunologica Scandinavica"	2026	Identification of Metastasis-Associated circRNA-miRNA-mRNA Network Reveals Novel Biomarkers and Therapy Strategies for Esophageal Cancer.	hsa_circ_0005360	circ_LDLR	hsa_circ_LDLR	LDLR	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	dysregulated	Microarray	"hsa_circ_0005360 was identified as one of six dysregulated circRNAs overlapping between ESCC circRNA microarray datasets. Its role was evaluated bioinformatically within a metastasis-associated ceRNA network, without circRNA-specific experimental validation."	0.1768
41494978	"APMIS : acta pathologica, microbiologica, et immunologica Scandinavica"	2026	Identification of Metastasis-Associated circRNA-miRNA-mRNA Network Reveals Novel Biomarkers and Therapy Strategies for Esophageal Cancer.	hsa_circ_0005771				esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	dysregulated	Microarray	"hsa_circ_0005771 was one of six DEcircRNAs identified from ESCC microarray datasets and included in the predicted metastasis-associated ceRNA network. Although methods list hsa_circ_0005771 constructs and primers, the reported positive validation results name hsa_circ_0007551, so hsa_circ_0005771 is treated as supported only by high-throughput/bioinformatic evidence."	0.1768
41494978	"APMIS : acta pathologica, microbiologica, et immunologica Scandinavica"	2026	Identification of Metastasis-Associated circRNA-miRNA-mRNA Network Reveals Novel Biomarkers and Therapy Strategies for Esophageal Cancer.	hsa_circ_0001727	circZKSCAN1	hsa_circ_ZKSCAN1	ZKSCAN1	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	dysregulated	Microarray	hsa_circ_0001727 was identified as a dysregulated circRNA in ESCC and metastatic lymph node datasets. The study included it in a predicted metastasis-associated ceRNA network but did not report individual experimental validation for this circRNA.	0.1768
41494978	"APMIS : acta pathologica, microbiologica, et immunologica Scandinavica"	2026	Identification of Metastasis-Associated circRNA-miRNA-mRNA Network Reveals Novel Biomarkers and Therapy Strategies for Esophageal Cancer.		hsa_circ_008681			esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	dysregulated	Microarray	"hsa_circ_008681 was identified as a dysregulated circRNA from ESCC circRNA microarray datasets. It was included in the six-circRNA ceRNA network, but the paper did not provide individual miRNA partners or experimental validation for it."	0.1768
41494978	"APMIS : acta pathologica, microbiologica, et immunologica Scandinavica"	2026	Identification of Metastasis-Associated circRNA-miRNA-mRNA Network Reveals Novel Biomarkers and Therapy Strategies for Esophageal Cancer.	hsa_circ_0007429				esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	dysregulated	Microarray	"hsa_circ_0007429 was identified as one of six dysregulated circRNAs in ESCC and metastatic lymph node microarray data. It was incorporated into the predicted ESCC metastasis ceRNA network, but no individual experimental validation or specific miRNA-mRNA axis was reported."	0.1768
41502012	Journal of biochemical and molecular toxicology	2026	CircMCM7 Promotes Hepatocellular Carcinoma Cell Proliferation and Metastasis By Modulating MCM7 Expression.	hsa_circ_0001729	circMCM7 	hsa_circ_MCM7	MCM7	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circMCM7 is an up-regulated oncogenic circRNA in hepatocellular carcinoma. It promotes HCC proliferation, invasion, metastasis and xenograft tumor growth while suppressing apoptosis, at least partly by positively regulating its host gene MCM7. High circMCM7 expression is associated with advanced TNM stage, lymph node metastasis and poor overall survival, supporting its potential as a prognostic biomarker and therapeutic target."	0.823
41508414	"Hematology (Amsterdam, Netherlands)"	2026	CIRC_0000075 targeting MIR-218-5P is involved in the prognosis and mechanism of acute myeloid leukemia.	hsa_circ_0000075	circ_0000075			acute myeloid leukemia 	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"circ_0000075 is up-regulated in AML bone marrow samples and AML cell lines. High circ_0000075 expression predicts worse survival, and silencing circ_0000075 suppresses AML cell proliferation, migration, and invasion. Mechanistically, circ_0000075 targets miR-218-5p, and miR-218-5p inhibition reverses the suppressive effects of circ_0000075 knockdown."	0.7283
41509520	3 Biotech	2026	CircFAM120B promotes prostate cancer progression through miR-1182 inhibition and FBXO17-mediated AKT activation.	hsa_circ_0001666	CircFAM120B 	hsa_circ_FAM120B	FAM120B	prostate cancer 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circFAM120B is a human FAM120B-derived circular RNA that is significantly upregulated in prostate cancer tissues and cell lines and is mainly localized in the cytoplasm. In PCa, it promotes proliferation, invasion, migration, EMT, tumor growth and metastasis while suppressing apoptosis by sponging miR-1182, upregulating FBXO17, and activating AKT signaling. The study suggests the circFAM120B/miR-1182/FBXO17/AKT axis as a potential therapeutic target."	0.8572
41518374	Apoptosis : an international journal on programmed cell death	2026	Role of circAGFG1 as an oncogene in triple-negative breast cancer.		circAGFG1	hsa_circ_AGFG1	AGFG1	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; ISH	"circAGFG1 is upregulated in TNBC tissues and TNBC-related cell models, and it acts as an oncogenic circRNA that promotes proliferation, G1/S cell-cycle transition, migration, and invasion. Mechanistically, YTHDF3 enhances circAGFG1 transcript stability and upregulates its expression, while circAGFG1 can sponge hsa-miR-1299. The study suggests circAGFG1 may serve as a biomarker and therapeutic target for TNBC."	0.7855
41519399	Biochemical pharmacology	2026	CircCramp1l targets the miR-532-3p/HMGB1/Drp1 axis to regulate allergic rhinitis.	hsa_circ_0003592	circCramp1l 	hsa_circ_Cramp1l	Cramp1l	allergic rhinitis 	MONDO:0011786	allergic rhinitis	up-regulated	RT-qPCR; RNA-seq	"circCramp1l, represented by mouse mmu_circ_0000731 and human homolog hsa_circ_0003592, is up-regulated in AR models and functions mainly in the cytoplasm. It promotes AR progression through a ceRNA mechanism by sponging miR-532-3p, increasing HMGB1, activating Drp1-dependent mitochondrial fission and P2X7R/TLR4/NLRP3 inflammatory signaling. Silencing circCramp1l alleviates AR symptoms, epithelial apoptosis, eosinophil infiltration, and Th2-type inflammation, suggesting therapeutic potential."	0.8416
41519399	Biochemical pharmacology	2026	CircCramp1l targets the miR-532-3p/HMGB1/Drp1 axis to regulate allergic rhinitis.	mmu_circ_0000731	circCramp1l 	mmu_circ_Cramp1l	Cramp1l	allergic rhinitis 	MONDO:0011786	allergic rhinitis	up-regulated	RT-qPCR; RNA-seq	"circCramp1l, represented by mouse mmu_circ_0000731 and human homolog hsa_circ_0003592, is up-regulated in AR models and functions mainly in the cytoplasm. It promotes AR progression through a ceRNA mechanism by sponging miR-532-3p, increasing HMGB1, activating Drp1-dependent mitochondrial fission and P2X7R/TLR4/NLRP3 inflammatory signaling. Silencing circCramp1l alleviates AR symptoms, epithelial apoptosis, eosinophil infiltration, and Th2-type inflammation, suggesting therapeutic potential."	0.8416
41534358	Ecotoxicology and environmental safety	2026	PM2.5-induced lung injury in rats: Identification of differential circRNAs and analysis of circRNA-miRNA-mRNA regulatory networks.		circRNA4503			PM2.5-induced lung injury 	MONDO:0043905	pneumonitis	down-regulated	RT-qPCR; RNA-seq	"circRNA4503 was down-regulated in rat lung tissue after PM2.5 exposure. The study proposes and validates that circRNA4503 binds miR-340-5p and is part of a circRNA-miRNA-mRNA regulatory axis affecting DMD, HECW2, and SGIP1 in PM2.5-induced lung injury."	0.6976
41534358	Ecotoxicology and environmental safety	2026	PM2.5-induced lung injury in rats: Identification of differential circRNAs and analysis of circRNA-miRNA-mRNA regulatory networks.		circRNA4511			PM2.5-induced lung injury 	MONDO:0043905	pneumonitis	down-regulated	RT-qPCR; RNA-seq	"circRNA4511 was down-regulated in rat lung tissue after PM2.5 exposure. The study proposes and validates that circRNA4511 binds miR-340-5p and is part of a circRNA-miRNA-mRNA regulatory axis affecting DMD, HECW2, and SGIP1 in PM2.5-induced lung injury."	0.6976
41534358	Ecotoxicology and environmental safety	2026	PM2.5-induced lung injury in rats: Identification of differential circRNAs and analysis of circRNA-miRNA-mRNA regulatory networks.		ciRNA131 			PM2.5-induced lung injury 	MONDO:0043905	pneumonitis	up-regulated	RNA-seq	"ciRNA131 was identified by sequencing as significantly up-regulated across PM2.5 exposure groups, although its RT-qPCR increase was reported as not significant. The study validates that ciRNA131 binds miR-340-5p and places it in a circRNA-miRNA-mRNA regulatory axis affecting DMD, HECW2, and SGIP1 in PM2.5-induced lung injury."	0.6581
41538967	Biosensors & bioelectronics	2026	Construction of a multilayer fluorescence-encoded single quantum dot-based FRET nanosensor for simple and sensitive monitoring of circular RNA in clinical tissues.		circMTO1	hsa_circ_MTO1	MTO1	breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	"This study used circMTO1 as the target circRNA for a single quantum dot-based FRET nanosensor and showed that circMTO1 expression is lower in breast cancer tissues than in healthy para-carcinoma tissues. The assay results were consistent with qRT-PCR and achieved ROC AUC = 1 for distinguishing breast cancer tissues from healthy counterparts, supporting circMTO1 monitoring as a potential diagnostic application."	0.4187
41539369	Molecular and cellular endocrinology	2026	circPTPRM can encode a functional polypeptide circPTPRM-187aa to promote papillary thyroid carcinoma progression.	hsa_circ_0007144	circPTPRM	hsa_circ_PTPRM	PTPRM	papillary thyroid carcinoma 	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"circPTPRM is up-regulated in papillary thyroid carcinoma and is associated with larger tumor diameter. It promotes PTC proliferation, migration, invasion, EMT-related changes and xenograft tumor growth by encoding circPTPRM-187aa, which binds IQGAP1, reduces IQGAP1 degradation, and up-regulates RAC1 and CDC42 in the TGF-beta signaling pathway."	0.8071
41544785	International journal of biological macromolecules	2026	"EIF4A3-induced circEIF2S2 facilitates colorectal cancer growth, metastasis, and immune suppression via the miR-646/UHMK1 Axis."	hsa_circ_0007938	circEIF2S2	hsa_circ_EIF2S2	EIF2S2	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circEIF2S2 is a human colorectal cancer-associated circRNA that is significantly upregulated in CRC tissues and cell lines and whose high expression predicts poorer survival. It functions as an oncogenic and immunosuppressive circRNA by sponging miR-646 to increase UHMK1 expression, thereby promoting proliferation, migration, invasion, tumor growth, liver metastasis, EMT, PD-L1 expression, and suppression of CD8+ T cell responses. EIF4A3 acts upstream to promote circEIF2S2 biogenesis through interaction with EIF2S2 pre-mRNA."	0.8913
41548986	"Brain pathology (Zurich, Switzerland)"	2026	A highly abundant circular RNA from the RMST locus plays a role in posterior fossa ependymoma pathogenesis.	hsa_circ_0099634	circRMST	hsa_circ_RMST	RMST	pediatric ependymoma 	MONDO:0003478	childhood ependymoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circRMST (hsa_circ_0099634), a circular RNA from the RMST locus, is upregulated and predominantly cytoplasmic in PF EPN cancer cells. Functional knockdown experiments indicate that circRMST acts oncogenically by supporting cell cycle progression, proliferation, and a cancer stem cell-like state while suppressing differentiation-related programs. High circRMST/RMST expression and low RMST promoter methylation are associated with poorer prognosis in PF EPN."	0.7414
41549901	Journal of biochemical and molecular toxicology	2026	CircDYRK1A Suppresses Gastric Cancer Progression via Sponging miR-331-5p to Regulate GADD45A.	hsa_circ_0001190	circDYRK1A 	hsa_circ_DYRK1A	DYRK1A	Gastric Cancer 	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"circDYRK1A is a human DYRK1A-derived circRNA that is significantly downregulated in gastric cancer tissues and cell lines. It suppresses GC proliferation, migration, invasion, and xenograft tumor growth by sponging miR-331-5p, thereby restoring GADD45A expression and activating the GADD45A-JNK tumor-suppressive pathway. Clinically, higher circDYRK1A expression is associated with better overall survival in GC patients."	0.8766
41555117	Inflammopharmacology	2026	CircRNA HIPK2-mediated metabolic reprogramming restores mitochondrial homeostasis in chondrocytes through the miR-206/Sirt3 signaling axis attenuating osteoarthritis-induced nociception.		circHIPK2 	hsa_circ_HIPK2	HIPK2	Osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR	"circHIPK2 is downregulated in OA chondrocytes and functions as a protective circRNA in OA. It sponges miR-206 to preserve SIRT3 expression and activity, thereby restoring mitochondrial homeostasis, oxidative phosphorylation, ATP production, and antioxidant function while suppressing glycolytic stress and apoptosis. In vivo AAV-mediated circHIPK2 delivery alleviates OA pain behaviors and cartilage degeneration in MIA and DMM rat models."	0.7289
41555117	Inflammopharmacology	2026	CircRNA HIPK2-mediated metabolic reprogramming restores mitochondrial homeostasis in chondrocytes through the miR-206/Sirt3 signaling axis attenuating osteoarthritis-induced nociception.		circHIPK2 	rno_circ_HIPK2	HIPK2	Osteoarthritis 	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR	"circHIPK2 is downregulated in OA chondrocytes and functions as a protective circRNA in OA. It sponges miR-206 to preserve SIRT3 expression and activity, thereby restoring mitochondrial homeostasis, oxidative phosphorylation, ATP production, and antioxidant function while suppressing glycolytic stress and apoptosis. In vivo AAV-mediated circHIPK2 delivery alleviates OA pain behaviors and cartilage degeneration in MIA and DMM rat models."	0.7289
41579303	Human cell	2026	Hsa_circ_0003176: a key player in the m6A modification-mediated regulation of autophagy and glycolysis in cisplatin-resistant non-small cell lung cancer.	hsa_circ_0003176				cisplatin-resistant non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"hsa_circ_0003176 is downregulated in DDP-resistant NSCLC cells and acts as a tumor suppressor that inhibits proliferation and glycolysis, promotes apoptosis and autophagy, and reverses cisplatin resistance. METTL3-mediated m6A modification suppresses hsa_circ_0003176 expression, while hsa_circ_0003176 directly destabilizes RPS6KB1 mRNA to attenuate mTORC1-related malignant and chemoresistant phenotypes."	0.7609
41580013	Cancer letters	2026	Exosomal circUBR5 drives metastasis and chemoresistance in gastric signet-ring cell carcinoma by reprogramming cholesterol metabolism through the hsa-miR-1208/CYP19A1 axis and ACAT1 upregulation.	hsa_circ_0001819	circUBR5	hsa_circ_UBR5	UBR5	gastric signet-ring cell carcinoma 	MONDO:0006409	signet ring cell gastric adenocarcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"CircUBR5/hsa_circ_0001819 is an upregulated human circRNA in GSRCC and broader GC contexts that promotes tumor proliferation, metastasis, and cisplatin resistance. It acts through dual mechanisms: a hsa-miR-1208/CYP19A1 ceRNA axis that activates estrogen signaling and a protein-scaffold mechanism recruiting PSMD14 to stabilize ACAT1 and reprogram cholesterol metabolism. CircUBR5 is also packaged into exosomes, enabling transfer of chemoresistance, and high expression predicts advanced disease and poor survival."	0.9036
41587007	Science China. Life sciences	2026	Targeting intratumoral Streptococcus mitis suppresses the progression of esophageal squamous cell carcinoma.	hsa_circ_0000620	circAAGAB	hsa_circ_AAGAB	AAGAB	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	RT-qPCR; RNA-seq	"circAAGAB is a human AAGAB-derived circRNA that is downregulated in ESCC tissues and patient blood/plasma, and low expression is associated with advanced TNM stage and shorter disease-free survival. It functions as a tumor suppressor by inhibiting ESCC proliferation, clonogenicity, migration, invasion, and tumor progression. Mechanistically, S. mitis-secreted MLY promotes ZNF460 proteasomal degradation to repress circAAGAB, while circAAGAB suppresses oncogenic signaling through the miR-671-5p/GAS7c/Sam68 and PABP1/TNFAIP2/Rac1 axes."	0.8966
41591629	Molecular and cellular biochemistry	2026	Hsa_circ_0002103 promotes progression of colorectal cancer via miR-193a-3p/CCND1 axis.	hsa_circ_0002103				colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"Hsa_circ_0002103 is upregulated in CRC cell lines and patient plasma. It promotes CRC progression by sponging miR-193a-3p to increase CCND1 expression, thereby facilitating proliferation, migration, invasion, EMT-related changes, and potential immune evasion while suppressing apoptosis. The study suggests hsa_circ_0002103 may be a therapeutic target and biomarker for CRC."	0.7519
41591629	Molecular and cellular biochemistry	2026	Hsa_circ_0002103 promotes progression of colorectal cancer via miR-193a-3p/CCND1 axis.	hsa_circ_0051239				colorectal cancer 	MONDO:0005575	colorectal cancer	dysregulated	Microarray	"Hsa_circ_0051239 was identified as an overlapping differentially expressed circRNA in two CRC microarray datasets. The study predicted potential downstream miRNAs and included it in a circRNA-miRNA-target gene network, but did not experimentally validate its expression or function beyond high-throughput and bioinformatic analyses."	0.1768
41601169	The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology	2026	Circular RNA circSmad4 controls pulmonary fibrosis.		circSmad4 	mmu_circ_Smad4	Smad4	pulmonary fibrosis 	MONDO:0002771	pulmonary fibrosis	up-regulated	RT-qPCR	"In this study, mouse circSmad4 was upregulated in TAC-induced and bleomycin-induced pulmonary fibrosis and in TGF-beta1-treated NIH3T3 fibroblast activation models. circSmad4 acted as a pro-fibrotic regulator through the miR-671-5p/Fgfr2 axis, promoting fibroblast activation, ECM/collagen deposition, and inflammatory cytokine production. Knockdown of circSmad4 alleviated pulmonary fibrosis phenotypes in vivo and reduced fibrosis-related gene expression and collagen secretion in vitro."	0.5798
41605366	Biochimica et biophysica acta. Molecular basis of disease	2026	Circ_0075691 regulates lipid metabolism in granulosa cells by interacting with EIF4A3 to promote PTGS2 mRNA stability.	hsa_circ_0075691		hsa_circ_ATXN1	ATXN1	polycystic ovary syndrome 	MONDO:0008487	polycystic ovary syndrome	up-regulated	RT-qPCR	"circ_0075691 is a human ATXN1-derived circRNA that is up-regulated in follicular fluid and granulosa cells from PCOS patients. It promotes PCOS-associated granulosa cell lipid metabolic dysfunction, oxidative stress, apoptosis, and reduced energy metabolism by interacting with EIF4A3, stabilizing EIF4A3 protein, and enhancing PTGS2 mRNA stability. The circ_0075691/EIF4A3/PTGS2 axis is proposed as a mechanistic contributor and potential therapeutic target in PCOS."	0.8279
41610425	Blood	2026	circPCMTD1: A protein-coding circular RNA that regulates DNA damage response in BCR/ABL1-positive leukemias.		circPCMTD1	hsa_circ_PCMTD1	PCMTD1	BCR	MONDO:0005059	leukemia	up-regulated	RT-qPCR	"circPCMTD1 is a protein-coding circRNA derived from PCMTD1 that is elevated in advanced CML stages and functionally supports BCR/ABL1-positive leukemic blast growth. It encodes cPCMTD1-127aa, which interacts with BCR/ABL1 and BTR complex components to promote BTR complex formation, DNA repair/genotoxic stress tolerance, proliferation and cell-cycle progression. Targeting circPCMTD1 suppresses leukemia growth, activates DDR, improves survival in patient-derived xenografts, and enhances TKI antileukemic activity."	0.7492
41615581	"Medical oncology (Northwood, London, England)"	2026	"The upregulated RNA circ_0060055 regulates the proliferation, invasion and apoptosis of pancreatic cancer cells through spongy miR-1298-5p."	hsa_circ_0060055		hsa_circ_EIF6	EIF6	pancreatic cancer 	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"hsa_circ_0060055/circ_0060055 is up-regulated in pancreatic cancer cell models and functions as an oncogenic circRNA. It promotes proliferation, migration, invasion, angiogenesis, vascular leakage and xenograft tumor growth while reducing apoptosis. Mechanistically, it sponges miR-1298-5p and is associated with changes in apoptosis-related proteins Bcl-2 and Bax, suggesting potential therapeutic relevance in PDAC."	0.6545
41616386	International immunopharmacology	2026	The circRNA0001707/miR-203a-3p/TLR4 regulatory axis drives macrophage polarization in enthesitis of newly diagnosed ankylosing spondylitis.	hsa_circ_0001707				ankylosing spondylitis 	MONDO:0005306	ankylosing spondylitis	up-regulated	RT-qPCR; RNA-seq; Microarray	"hsa_circ_0001707 is up-regulated in PBMCs from AS patients, especially those with enthesitis, and may serve as a biomarker for AS-associated enthesitis. Functionally, it promotes pro-inflammatory M1 macrophage polarization and suppresses M2-like polarization through a hsa_circ_0001707/miR-203a-3p/TLR4 ceRNA axis."	0.7973
41616386	International immunopharmacology	2026	The circRNA0001707/miR-203a-3p/TLR4 regulatory axis drives macrophage polarization in enthesitis of newly diagnosed ankylosing spondylitis.	hsa_circ_0075522				ankylosing spondylitis 	MONDO:0005306	ankylosing spondylitis	down-regulated	RT-qPCR; RNA-seq; Microarray	"hsa_circ_0075522 was identified among down-regulated circRNAs in PBMCs from AS patients and remained lower in the expanded AS cohort compared with healthy controls. Unlike hsa_circ_0001707, it was not significantly associated with enthesitis and no mechanistic role was investigated."	0.4773
41616622	Journal of hazardous materials	2026	"Cadmium-induced POLN mutations promote m6A-dependent circ_FANCA degradation via endoribonucleolytic cleavage, triggering TCA cycle activation and oncogenic transformation."		Circ_0041057 	hsa_circ_FANCA	FANCA	Cd-induced malignant transformation 	MONDO:0004992	cancer	down-regulated	RT-qPCR; RNA-seq	"circ_FANCA is down-regulated during Cd-induced malignant transformation and acts as a tumor suppressor. Cd-induced POLN mutations promote m6A-dependent degradation of circ_FANCA through YTHDF2 and the HRSP12-POP1 endonuclease complex. Loss of circ_FANCA releases MYC-dependent metabolic reprogramming involving ACLY/ASCT2 and the TCA cycle, thereby enhancing malignant phenotypes."	0.8225
41616946	Brain research bulletin	2026	CircHIPK3 regulates TGF-beta1/smad3 signaling in communicating hydrocephalus after intraventricular hemorrhage by sponging miR-30a-3p via ACT1.			rno_circ_HIPK3	HIPK3	communicating hydrocephalus after intraventricular hemorrhage 	MONDO:0001150	hydrocephalus	up-regulated	RT-qPCR	"In rat IVH and thrombin-stimulated astrocyte models, circHIPK3 is up-regulated and promotes post-IVH communicating hydrocephalus by driving meningeal/periventricular fibrosis. Mechanistically, circHIPK3 sponges miR-30a-3p, increases ACT1(TRAF3IP2), activates TGF-beta1/Smad3 signaling, and promotes fibrotic proteins such as Col1 and alpha-SMA. Knockdown of circHIPK3 alleviates fibrosis, ventricular enlargement, and neurological dysfunction, supporting its potential as a therapeutic target."	0.657
41619596	Journal of hazardous materials	2026	Circ_0001839 modulates the oncogenic MYCL rs1038259890 (p.G83S) mutation to promote B[a]P-induced malignant transformation in 16HBE cells.	hsa_circ_0001839	circ_0001839	hsa_circ_KDM4C	KDM4C	B[a]P-induced malignant transformation 	MONDO:0005070	neoplasm	down-regulated	RT-qPCR; RNA-seq	"circ_0001839 is a KDM4C-derived human circRNA that is downregulated during B[a]P-induced malignant transformation and in lung cancer cell lines. It acts as a tumor suppressor: overexpression inhibits proliferation and migration, whereas knockdown promotes these malignant phenotypes and accelerates acquisition of the oncogenic MYCL rs1038259890/p.Gly83Ser mutation. The study proposes circ_0001839 as a potential early biomarker and preventive or therapeutic target for environmentally induced lung carcinogenesis."	0.6628
41619923	Cellular signalling	2026	Circ_Mkrn2 facilitates the progression of atrial fibrillation via sponging miR-10b-5p.		circRNA_4760 	hsa_circ_Mkrn2	Mkrn2	atrial fibrillation 	MONDO:0004981	atrial fibrillation	up-regulated	RT-qPCR; RNA-seq	"circ_Mkrn2 is up-regulated in atrial tissues from AF patients and CIH-exposed rats, as well as in atrial fibroblasts under CIH. It promotes atrial fibroblast proliferation, migration, activation, extracellular matrix remodeling, atrial fibrosis and AF development by sponging miR-10b-5p and increasing SMURF1-dependent TGF-beta/Smad signaling. Silencing circ_Mkrn2 attenuates CIH-induced atrial fibrosis and AF susceptibility, supporting its potential as a therapeutic target."	0.807
41619923	Cellular signalling	2026	Circ_Mkrn2 facilitates the progression of atrial fibrillation via sponging miR-10b-5p.		circRNA_4760 	rno_circ_Mkrn2	Mkrn2	atrial fibrillation 	MONDO:0004981	atrial fibrillation	up-regulated	RT-qPCR; RNA-seq	"circ_Mkrn2 is up-regulated in atrial tissues from AF patients and CIH-exposed rats, as well as in atrial fibroblasts under CIH. It promotes atrial fibroblast proliferation, migration, activation, extracellular matrix remodeling, atrial fibrosis and AF development by sponging miR-10b-5p and increasing SMURF1-dependent TGF-beta/Smad signaling. Silencing circ_Mkrn2 attenuates CIH-induced atrial fibrosis and AF susceptibility, supporting its potential as a therapeutic target."	0.807
41621384	International immunopharmacology	2026	CircUBXN7 as a prognostic risk biomarker for ARDS modulates LPS-stimulated lung epithelial cell injury and the inflammatory response by competitively binding miR-622.		circUBXN7 	hsa_circ_UBXN7		Acute Respiratory Distress Syndrome 	MONDO:0006502	acute respiratory distress syndrome	up-regulated	RT-qPCR	"circUBXN7 is up-regulated in plasma from ARDS patients and further elevated in severe ARDS and non-survivors, supporting its potential value as a prognostic biomarker. Functionally, circUBXN7 promotes LPS-induced inflammatory cytokine expression and epithelial barrier damage in A549 and Beas-2B cells. Mechanistically, it acts through competitive binding to miR-622, thereby weakening miR-622-mediated regulation of downstream target genes."	0.6719
41635938	ACS nano	2026	circTNIK Promotes Carbon Nanotubes-Induced Lung Carcinogenesis via GRP78-Mediated Endoplasmic Reticulum Stress and Suppression of Type I Interferon Signaling.	hsa_circ_0002387	circTNIK	hsa_circ_TNIK	TNIK	CNTs-induced lung carcinogenesis 	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circTNIK is an upregulated human circRNA derived from TNIK in CNTs-induced lung malignant transformation and clinical lung cancer tissues. It promotes malignant phenotypes by binding GRP78 to activate ER stress and by driving GRP78-dependent suppression of NF-kappaB/IRF3-mediated IFN-I antitumor immunity. Its expression is enhanced by METTL14/YTHDF1-mediated m6A regulation, and it may have biomarker and therapeutic-target value in environmental-exposure-related lung cancer."	0.8861
41636073	The Analyst	2026	CRISPR/Cas13a-induced self-priming cyclic amplification enables liquid biopsy of exosomal circular RNA in non-small cell lung cancer.	hsa_circ_0003026				non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"This study developed and applied a CRISPR/Cas13a-induced self-priming cyclic amplification assay to detect exosomal hsa_circ_0003026. hsa_circ_0003026 was significantly upregulated in serum exosomes from NSCLC patients compared with healthy controls, supporting its potential as a liquid biopsy biomarker for NSCLC diagnosis."	0.208
41641542	"Hypertension (Dallas, Tex. : 1979)"	2026	circMFN2 Regulates the IGF2BP3-PDK4 to Ameliorate Pulmonary Hypertension.		circMFN2 	hsa_circ_MFN2	MFN2	pulmonary hypertension 	MONDO:0005149	pulmonary hypertension	down-regulated	RT-qPCR; ISH	"circMFN2 is a PH-related circRNA generated from the MFN2 locus and is downregulated in PH patient peripheral blood, PH mouse pulmonary arteries/lung tissues, and hypoxic hPASMCs. It acts as a protective regulator by binding IGF2BP3, reducing IGF2BP3-mediated PDK4 mRNA stabilization, restoring mitochondrial homeostasis and oxidative phosphorylation, and suppressing hPASMC proliferation, cell cycle progression, migration, and vascular remodeling. Intranasal R8-liposome-mediated circMFN2 delivery improved pulmonary hemodynamics and vascular remodeling in Su/Hyp PH mice, supporting therapeutic potential."	0.824
41649274	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2026	Cardiac Circ-ZNF609 Inhibition Attenuates Doxorubicin-Induced Cardiotoxicity Without Affecting the Chemotherapeutic Efficacy of Doxorubicin on Cancer in Female Mice.	mmu_circ_0000615	Circ-ZNF609	mmu_circ_Znf609	Znf609	DOX-induced cardiotoxicity 	MONDO:0023006	doxorubicin induced cardiomyopathy	unknown	RT-qPCR	"This study investigates cardiac circ-ZNF609 inhibition in a DOX-treated, tumor-bearing female mouse model. Knockdown of circ-ZNF609 in the heart alleviates DOX-induced cardiotoxicity, including cardiac dysfunction, injury, atrophy, apoptosis, and fibrosis, while preserving DOX anti-tumor efficacy. The cardioprotective mechanism may involve increased FTO expression and reduced cardiac RNA m6A methylation."	0.3957
41653210	Molecular genetics and genomics : MGG	2026	Circ-FoxO3 alleviates APOE4-induced brain pathology through FoxO3-mediated autophagy.		circular RNA FoxO3 	mmu_circ_FoxO3	FoxO3	Alzheimer's disease 	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR	"circ-FoxO3 is downregulated in the brains of APOE4 transgenic mice with AD-like neuropathology. Its overexpression reduces p-tau and Abeta accumulation, whereas knockdown worsens these aggregates. Mechanistically, circ-FoxO3 promotes FoxO3-mediated autophagy, suggesting therapeutic potential for APOE4-related neurodegenerative pathology."	0.414
41655237	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2026	Mitochondrial CircRNA CircMT-RNR2 Safeguards Antioxidant Defense to Support Fibroblast Functions in Wound Repair.		CircMT-RNR2 	hsa_circ_MT-RNR2	MT-RNR2	diabetic foot ulcers 	MONDO:0000960	diabetic peripheral angiopathy	down-regulated	RT-qPCR; RNA-seq	"CircMT-RNR2 is a mitochondria-encoded circRNA downregulated in DFU tissue and diabetic wounds. It binds and stabilizes PRDX3 to preserve mitochondrial antioxidant defense, reduce ROS-related mitochondrial damage and mitophagy, and support fibroblast proliferation, migration, ECM production, contraction, and wound healing."	0.8395
41655237	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2026	Mitochondrial CircRNA CircMT-RNR2 Safeguards Antioxidant Defense to Support Fibroblast Functions in Wound Repair.		CircMT-RNR2 	mmu_circ_MT-RNR2	MT-RNR2	diabetic foot ulcers 	MONDO:0000960	diabetic peripheral angiopathy	down-regulated	RT-qPCR; RNA-seq	"CircMT-RNR2 is a mitochondria-encoded circRNA downregulated in DFU tissue and diabetic wounds. It binds and stabilizes PRDX3 to preserve mitochondrial antioxidant defense, reduce ROS-related mitochondrial damage and mitophagy, and support fibroblast proliferation, migration, ECM production, contraction, and wound healing."	0.8395
41662509	Advances in clinical and experimental medicine : official organ Wroclaw Medical University	2026	Expression profile of circular RNA in angiotensin II-mediated abdominal aortic aneurysm in mice: A microarray analysis.		circRNA_30395 			abdominal aortic aneurysm 	MONDO:0005350	abdominal aortic aneurysm	up-regulated	RT-qPCR; Microarray	"circRNA_30395 was significantly upregulated in Ang II-induced AAA mouse aortic tissues and was validated by RT-qPCR. Bioinformatic ceRNA analysis suggested that its predicted target genes were enriched in the autophagy pathway, implying a possible role in AAA molecular pathogenesis."	0.4851
41662509	Advances in clinical and experimental medicine : official organ Wroclaw Medical University	2026	Expression profile of circular RNA in angiotensin II-mediated abdominal aortic aneurysm in mice: A microarray analysis.		circRNA_30398 			abdominal aortic aneurysm 	MONDO:0005350	abdominal aortic aneurysm	up-regulated	RT-qPCR; Microarray	circRNA_30398 was significantly upregulated in Ang II-induced AAA mouse aortic tissues and validated by RT-qPCR. The study predicted that mmu_circRNA_30398 may promote AAA progression through a circRNA_30398/miR-136-5p/MMP-2 axis and may also be linked to autophagy-related ceRNA regulation.	0.4851
41662509	Advances in clinical and experimental medicine : official organ Wroclaw Medical University	2026	Expression profile of circular RNA in angiotensin II-mediated abdominal aortic aneurysm in mice: A microarray analysis.		circRNA_012594 			abdominal aortic aneurysm 	MONDO:0005350	abdominal aortic aneurysm	up-regulated	RT-qPCR; Microarray	"circRNA_012594 was significantly upregulated in Ang II-induced AAA mouse aortic tissues and validated by RT-qPCR. It was included among the validated dysregulated circRNAs used to construct a predicted circRNA-miRNA-mRNA network, but no specific downstream axis was detailed in the provided text."	0.4851
41662509	Advances in clinical and experimental medicine : official organ Wroclaw Medical University	2026	Expression profile of circular RNA in angiotensin II-mediated abdominal aortic aneurysm in mice: A microarray analysis.		circRNA_006097 			abdominal aortic aneurysm 	MONDO:0005350	abdominal aortic aneurysm	down-regulated	RT-qPCR; Microarray	"circRNA_006097 was significantly downregulated in Ang II-induced AAA mouse aortic tissues and validated by RT-qPCR. Bioinformatic analysis predicted interactions with miR-448-3p, miR-337-3p and miR-432, and suggested that circRNA_006097 may affect AAA formation by regulating VSMC function and autophagy-related ceRNA pathways."	0.4851
41662509	Advances in clinical and experimental medicine : official organ Wroclaw Medical University	2026	Expression profile of circular RNA in angiotensin II-mediated abdominal aortic aneurysm in mice: A microarray analysis.		circRNA_009932 			abdominal aortic aneurysm 	MONDO:0005350	abdominal aortic aneurysm	down-regulated	RT-qPCR; Microarray	circRNA_009932 was significantly downregulated in Ang II-induced AAA mouse aortic tissues and validated by RT-qPCR. The study predicted that circRNA_009932 may act through miR-222-5p and downstream smooth muscle differentiation-related molecules such as ROCK2 and alpha-smooth muscle actin.	0.4851
41664364	Current medicinal chemistry	2026	Inhibition of Circular RNA 006029 Alleviates Pancreatic beta-Cell Injury Through the AKT/mTOR Signaling Pathway.		circRNA 006029 	mmu_circ_CCAR1	CCAR1	Type 1 Diabetes Mellitus 	MONDO:0005147	type 1 diabetes mellitus	up-regulated	RT-qPCR; Microarray	"circ006029 is up-regulated in cytokine-induced injured MIN6 pancreatic beta-cells and appears to act detrimentally in the T1DM beta-cell injury context. Its knockdown protects beta-cells by promoting proliferation and autophagy while reducing apoptosis and inflammation, mainly through regulation of the AKT/mTOR and NF-kappaB signaling pathways."	0.7379
41665194	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2026	Circular RNA circFNDC3B Modulates M2 Macrophage Activation and Intestinal Inflammation in Crohn's Disease.		CircRNA_103516 	hsa_circ_FNDC3B	FNDC3B	Crohn's disease 	MONDO:0005011	Crohn disease	up-regulated	RT-qPCR; ISH; Microarray	"circFNDC3B is a human FNDC3B-derived circRNA upregulated in peripheral blood monocytes and inflamed mucosa of active Crohn's disease. It is mainly nuclear and regulates monocyte-macrophage behavior through a HuR/FNDC3B/TGFbeta mechanism; circFNDC3B knockdown promotes FNDC3B expression, M2 macrophage polarization, adhesion, and transmigration. Clinically, higher circFNDC3B levels correlate positively with CD activity and inflammation indices."	0.8237
41666156	Brain : a journal of neurology	2026	Penumbra-derived small extracellular vesicles carry pathogenic RNA driving remote damage after cortical infarction.		CircOGDH	mmu_circ_OGDH	OGDH	ischemic stroke 	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; ISH	"CircOGDH is upregulated in the ischemic penumbra and enriched in penumbra-derived extracellular vesicles after focal cortical infarction. PEVs transport CircOGDH along corticothalamic synaptic pathways to thalamic neurons, where it drives remote neuronal apoptosis, neuronal loss, and synaptic impairment. Knockdown of cortical CircOGDH reduces thalamic CircOGDH accumulation and alleviates corticothalamic pathway damage."	0.4636
41667113	European heart journal	2026	"Macrophage-specific circular RNA circHIPK2, inflammation, and fibrosis after myocardial infarction."	hsa_circ_0001756	circHIPK2	hsa_circ_HIPK2	HIPK2	myocardial infarction 	MONDO:0005068	myocardial infarction	up-regulated	RT-qPCR; RNA-seq	"circHIPK2 is a HIPK2-derived circRNA upregulated in inflammatory cardiac macrophages after MI and in human HF/ICM-related samples. It promotes pro-inflammatory macrophage polarization by interacting with G3BP1 to facilitate stress granule formation and downstream NF-kappaB-linked inflammatory signalling. Macrophage-specific circHIPK2 inhibition reduces inflammation, cytokine secretion, fibroblast activation and fibrosis, improves post-MI cardiac function, and shows translational therapeutic potential in human myocardial slice co-culture models."	0.8816
41667113	European heart journal	2026	"Macrophage-specific circular RNA circHIPK2, inflammation, and fibrosis after myocardial infarction."	mmu_circ_0001468	circHIPK2	mmu_circ_HIPK2	HIPK2	myocardial infarction 	MONDO:0005068	myocardial infarction	up-regulated	RT-qPCR; RNA-seq	"circHIPK2 is a HIPK2-derived circRNA upregulated in inflammatory cardiac macrophages after MI and in human HF/ICM-related samples. It promotes pro-inflammatory macrophage polarization by interacting with G3BP1 to facilitate stress granule formation and downstream NF-kappaB-linked inflammatory signalling. Macrophage-specific circHIPK2 inhibition reduces inflammation, cytokine secretion, fibroblast activation and fibrosis, improves post-MI cardiac function, and shows translational therapeutic potential in human myocardial slice co-culture models."	0.8816
41667113	European heart journal	2026	"Macrophage-specific circular RNA circHIPK2, inflammation, and fibrosis after myocardial infarction."	hsa_circ_0001756	circHIPK2	hsa_circ_HIPK2	HIPK2	heart failure	MONDO:0005252	heart failure	up-regulated	RT-qPCR; RNA-seq	"circHIPK2 is a HIPK2-derived circRNA upregulated in inflammatory cardiac macrophages after MI and in human HF/ICM-related samples. It promotes pro-inflammatory macrophage polarization by interacting with G3BP1 to facilitate stress granule formation and downstream NF-kappaB-linked inflammatory signalling. Macrophage-specific circHIPK2 inhibition reduces inflammation, cytokine secretion, fibroblast activation and fibrosis, improves post-MI cardiac function, and shows translational therapeutic potential in human myocardial slice co-culture models."	0.8816
41667113	European heart journal	2026	"Macrophage-specific circular RNA circHIPK2, inflammation, and fibrosis after myocardial infarction."	mmu_circ_0001468	circHIPK2	mmu_circ_HIPK2	HIPK2	heart failure	MONDO:0005252	heart failure	up-regulated	RT-qPCR; RNA-seq	"circHIPK2 is a HIPK2-derived circRNA upregulated in inflammatory cardiac macrophages after MI and in human HF/ICM-related samples. It promotes pro-inflammatory macrophage polarization by interacting with G3BP1 to facilitate stress granule formation and downstream NF-kappaB-linked inflammatory signalling. Macrophage-specific circHIPK2 inhibition reduces inflammation, cytokine secretion, fibroblast activation and fibrosis, improves post-MI cardiac function, and shows translational therapeutic potential in human myocardial slice co-culture models."	0.8816
41667113	European heart journal	2026	"Macrophage-specific circular RNA circHIPK2, inflammation, and fibrosis after myocardial infarction."	hsa_circ_0001756	circHIPK2	hsa_circ_HIPK2	HIPK2	ischaemic cardiomyopathy	MONDO:0024644	myocardial ischemia	up-regulated	RT-qPCR; RNA-seq	"circHIPK2 is a HIPK2-derived circRNA upregulated in inflammatory cardiac macrophages after MI and in human HF/ICM-related samples. It promotes pro-inflammatory macrophage polarization by interacting with G3BP1 to facilitate stress granule formation and downstream NF-kappaB-linked inflammatory signalling. Macrophage-specific circHIPK2 inhibition reduces inflammation, cytokine secretion, fibroblast activation and fibrosis, improves post-MI cardiac function, and shows translational therapeutic potential in human myocardial slice co-culture models."	0.8816
41667113	European heart journal	2026	"Macrophage-specific circular RNA circHIPK2, inflammation, and fibrosis after myocardial infarction."	mmu_circ_0001468	circHIPK2	mmu_circ_HIPK2	HIPK2	ischaemic cardiomyopathy	MONDO:0024644	myocardial ischemia	up-regulated	RT-qPCR; RNA-seq	"circHIPK2 is a HIPK2-derived circRNA upregulated in inflammatory cardiac macrophages after MI and in human HF/ICM-related samples. It promotes pro-inflammatory macrophage polarization by interacting with G3BP1 to facilitate stress granule formation and downstream NF-kappaB-linked inflammatory signalling. Macrophage-specific circHIPK2 inhibition reduces inflammation, cytokine secretion, fibroblast activation and fibrosis, improves post-MI cardiac function, and shows translational therapeutic potential in human myocardial slice co-culture models."	0.8816
41670172	Journal of the American Chemical Society	2026	Synchronous 3D-DNA Walking-Driven Dual-Color RNA Aptamers Lighting-Up for Label-Free and Attomolar Profiling of Multiple circRNAs in Breast Cancer.		circMTO1	hsa_circ_MTO1	MTO1	breast cancer	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	"circMTO1 is a human MTO1-derived circRNA that was measured in breast cancer cells and clinical breast tissues. The study found circMTO1 down-regulation in breast cancer tissues and used it together with circCDYL as a diagnostic and staging biomarker, validated by the authors' nanodevice and qRT-PCR."	0.559
41670172	Journal of the American Chemical Society	2026	Synchronous 3D-DNA Walking-Driven Dual-Color RNA Aptamers Lighting-Up for Label-Free and Attomolar Profiling of Multiple circRNAs in Breast Cancer.		circCDYL	hsa_circ_CDYL	CDYL	breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circCDYL is a human CDYL-derived circRNA that was measured in breast cancer cells and clinical breast tissues. The study found circCDYL up-regulation in breast cancer tissues and used it together with circMTO1 as a diagnostic and staging biomarker, validated by the authors' nanodevice and qRT-PCR."	0.559
41677124	ACS infectious diseases	2026	The Circular RNA hsa_circ_0004771 Regulates the Intracellular Survival of Mycobacterium tuberculosis in Macrophages by Targeting hsa-miR-3921 to Increase TREM1 Expression.	hsa_circ_0004771		hsa_circ_NRIP1	NRIP1	tuberculosis 	MONDO:0018076	tuberculosis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0004771 is upregulated in M.tb-infected THP-1 macrophages and functions as a host defense circRNA. It sponges hsa-miR-3921 to increase TREM1 expression, enhances NF-kappaB P65 phosphorylation and IL-1beta production, and thereby suppresses intracellular survival of M.tb."	0.7519
41677371	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2026	"CircRSU1 Activates the hnRNPA1/HIF-1alpha/CD24 Signaling Axis, Promoting Stemness Features of Hepatocellular Carcinoma."		circRSU1	hsa_circ_RSU1	RSU1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"circRSU1 is up-regulated in HCC tumor tissues and promotes malignant and stemness phenotypes in HCC cells and mouse models. Mechanistically, it binds hnRNPA1, stabilizes hnRNPA1 protein, enhances hnRNPA1 interaction with HIF1A IRES, increases HIF-1 alpha translation, and expands the CD24 positive CSC-like population."	0.8676
41677375	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2026	Ascites circRNA ASCOR Drives Platinum Resistance of High-Grade Serous Ovarian Cancer by Facilitating RPA1 Nuclear Translocation.	hsa_circ_0000842	ASCOR	hsa_circ_RPRD1A	RPRD1A	High-grade serous ovarian carcinoma 	MONDO:0005211	ovarian serous adenocarcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"ASCOR (hsa_circ_0000842), derived from RPRD1A, is upregulated in ascites-derived small extracellular vesicles and matched tumor tissues from platinum-resistant HGSOC patients, and high ASCOR predicts poor progression-free survival. Functionally, ASCOR promotes cisplatin/platinum resistance by increasing cell viability and proliferation, reducing apoptosis and DNA damage, and transferring resistance via sEVs. Mechanistically, ASCOR binds RPA1, promotes NUP153-dependent RPA1 nuclear translocation, enhances DDX18 recruitment, suppresses R-loop formation, and activates PI3K/Akt signaling; ASO-mediated ASCOR targeting reverses chemoresistance in mouse models."	0.8942
41679563	Free radical biology & medicine	2026	Silencer-regulated circLSM14A inhibits autophagy of pulmonary artery smooth muscle cells through parental protein LSM14A.		CircLSM14A	hsa_circ_LSM14A	LSM14A	Pulmonary hypertension 	MONDO:0005149	pulmonary hypertension	down-regulated	RT-qPCR; ISH	"CircLSM14A is a human LSM14A-derived circular RNA that is down-regulated in hypoxic HPASMCs and SuHx-induced PH mouse lung tissue. It inhibits hypoxia-induced PASMC autophagy and pulmonary vascular remodeling by binding host protein LSM14A, promoting LSM14A ubiquitination/degradation, and indirectly suppressing YBX1 SUMOylation-dependent Beclin1 transcription. Its hypoxic repression is linked to silencer/H3K27me3-mediated ZNF281 recruitment, and the study proposes circLSM14A as a potential therapeutic or diagnostic target for pulmonary hypertension."	0.8558
41686430	Archivum immunologiae et therapiae experimentalis	2026	Mechanism of RBM15 in Regulating PD-L1-Mediated Immune Escape in Ovarian Cancer Through the JAK2/STAT3/STAT5 Pathway.			hsa_circ_FGFR3	FGFR3	ovarian cancer 	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circFGFR3 is upregulated in ovarian cancer cells and acts as a pro-tumor and pro-immune-escape circRNA. RBM15 increases circFGFR3 expression via m6A modification, while circFGFR3 recruits EIF4A3 to stabilize JAK2, STAT3, and STAT5 mRNAs, activating JAK/STAT signaling and increasing PD-L1-mediated immune evasion."	0.8119
41686469	Autoimmunity	2026	Exosomal circ_001895 from lung cancer cells drives M2 macrophage polarization via the miR-20a-5p/JAK1/STAT3 axis to promote tumor progression.		circ_001895			lung cancer 	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circ_001895 is up-regulated in lung cancer tissues, lung cancer cell lines, and macrophages treated with lung cancer cell-derived exosomes. Exosomal circ_001895 promotes lung cancer progression and metastasis by sponging miR-20a-5p, increasing JAK1/STAT3 signaling, and inducing M2 macrophage polarization. The study suggests exosomal circ_001895 as a potential biomarker and therapeutic target for lung cancer."	0.817
41699263	Mammalian genome : official journal of the International Mammalian Genome Society	2026	Hypoxia-induced circ_0017521 enhances glycolysis and promotes NSCLC progression via upregulating the PFKFB3/PI3K-AKT pathway.	hsa_circ_0017521	circ_0017521 	hsa_circ_AKR1E2	AKR1E2	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"Hypoxia-induced circ_0017521 is up-regulated in NSCLC tissues and hypoxic NSCLC cells and functions as an oncogenic circRNA. It promotes proliferation, migration, invasion, EMT, glycolysis and xenograft tumor growth by sponging miR-532-3p to upregulate PFKFB3 and activate PI3K/AKT/mTOR signaling, while circ_0017521 knockdown increases apoptosis and suppresses malignant progression."	0.8355
41702192	Biosensors & bioelectronics	2026	Magnetic Fe3O4-Au@UIO-66-NH2@toehold probe mediated fluorescent sensor for detecting ovarian cancer-specific circRNA coupled with hybridization chain reaction and the CRISPR-Cas12a system.	hsa_circ_0051240	circ_0051240	hsa_circ_CEACAM5	CEACAM5	ovarian cancer	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"This study focused on circ_0051240 as an ovarian cancer-specific circRNA target rather than investigating its biological function. The authors developed a Fe3O4-Au@UIO-66-NH2 toehold probe-mediated HCR/CRISPR-Cas12a fluorescent sensor that recognizes the back-splice junction of circ_0051240 and validated relative expression trends in human cell lines with RT-qPCR. circ_0051240 showed higher signal in SK-OV-3 ovarian cancer cells than in IOSE80 cells, supporting its potential value for ovarian cancer-related detection."	0.329
41703266	Molecular psychiatry	2026	A brain-enriched circRNA blood biomarker can predict response to SSRI antidepressants.		CDR1as			Major Depressive Disorder 	MONDO:0002009	major depressive disorder	dysregulated	RT-qPCR	"CDR1as is a brain-enriched circRNA measured in blood that can predict response and remission to SSRI antidepressants in patients with MDD, particularly sertraline. Baseline CDR1as is higher in future sertraline non-responders/non-remitters than responders/remitters, while post-treatment upregulation in responders is associated with remission. Mechanistically, mouse and neuronal culture experiments suggest Cdr1as expression is regulated by 5-HT2A and BDNF/TrkB-mediated ERK/CREB signaling."	0.6608
41703266	Molecular psychiatry	2026	A brain-enriched circRNA blood biomarker can predict response to SSRI antidepressants.		Cdr1as			Major Depressive Disorder 	MONDO:0002009	major depressive disorder	dysregulated	RT-qPCR	"CDR1as is a brain-enriched circRNA measured in blood that can predict response and remission to SSRI antidepressants in patients with MDD, particularly sertraline. Baseline CDR1as is higher in future sertraline non-responders/non-remitters than responders/remitters, while post-treatment upregulation in responders is associated with remission. Mechanistically, mouse and neuronal culture experiments suggest Cdr1as expression is regulated by 5-HT2A and BDNF/TrkB-mediated ERK/CREB signaling."	0.6608
41711097	Molecular oncology	2026	Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression.	hsa_circ_0000228	circZEB1	hsa_circ_ZEB1	ZEB1	myelodysplastic neoplasms 	MONDO:0018881	myelodysplastic syndrome	up-regulated	RNA-seq	"circZEB1 (hsa_circ_0000228) is upregulated in MDS, particularly in cases with SF3B1 mutations. In the independent ring sideroblast cohort, high circZEB1 expression among SF3B1-mutated patients was associated with poorer overall survival, suggesting clinical biomarker potential rather than a mechanistically validated functional role."	0.5121
41711097	Molecular oncology	2026	Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression.		circARID1B	hsa_circ_ARID1B	ARID1B	myelodysplastic neoplasms 	MONDO:0018881	myelodysplastic syndrome	up-regulated	RNA-seq	"circARID1B is one of the significantly upregulated circRNAs in MDS compared with healthy controls. It was the individual circRNA most strongly associated with AML progression risk, with high expression marking a much higher cumulative incidence of AML."	0.459
41722799	International journal of biological macromolecules	2026	CircTHBS1 stabilizes N-acetyltransferase 10 to promote N4-acetylcytidine-dependent Rab8a translation and autophagy in esophageal squamous cell carcinoma.	hsa_circ_0034447	circTHBS1	hsa_circ_THBS1	THBS1	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circTHBS1 is up-regulated in ESCC and functions as an oncogenic circRNA associated with poor prognosis. It binds and stabilizes NAT10 by preventing ubiquitin-mediated proteasomal degradation, thereby enhancing ac4C-dependent Rab8a translation, promoting autophagy, proliferation, migration, and tumor progression."	0.8707
41725567	Current eye research	2026	The Potential Regulatory Roles of Hsa_Circ_0002629/Hsa-miR-532-3p axis for the Retina Neovascularization in Diabetic Retinopathy In Vitro and In Vivo.	hsa_circ_0002629		hsa_circ_SUZ12	SUZ12	diabetic retinopathy 	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0002629 is up-regulated in aqueous humor from DR patients and in high-glucose-treated hRECs. It promotes hREC proliferation, DNA synthesis, migration, wound healing, and tube formation by interacting with hsa-miR-532-3p and regulating the HMGA2-related signaling pathway, including beta-catenin phosphorylation and c-Myc expression. The hsa_circ_0002629/hsa-miR-532-3p/HMGA2 axis is proposed as a potential diagnostic and therapeutic target for diabetic retinopathy."	0.7956
41729211	Journal of molecular histology	2026	The IGF2BP3/SLC2A1 axis mediates hsa_circ_0000376-Induced malignant progression and neutrophil N2 polarization in the lung adenocarcinoma microenvironment.	hsa_circ_0000376	Homo sapiens circular RNA 0000376			lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000376 is upregulated in LUAD tissues and cell lines and high expression is associated with advanced TNM stage, lymph node metastasis, and poor overall survival. Functionally, it promotes LUAD cell proliferation, migration, invasion, tumor growth, glycolytic activity, and neutrophil N2 polarization while suppressing apoptosis. Mechanistically, hsa_circ_0000376 binds IGF2BP3 and stabilizes SLC2A1 mRNA, defining a hsa_circ_0000376/IGF2BP3/SLC2A1 regulatory axis in LUAD."	0.8611
41730444	International journal of biological macromolecules	2026	"Structure-guided engineering of modular RNA aptamer biosensors for one-pot, multiplex detection of CircRNAs."		circSMARCA5	hsa_circ_SMARCA5	SMARCA5	bladder cancer	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"This study used circSMARCA5 as one of two bladder cancer-associated circRNA biomarkers to validate a modular fluorescent RNA aptamer biosensor. The platform detected circSMARCA5 with femtomolar sensitivity, distinguished target circRNA from related nucleic acids, and showed higher tumor-tissue signals in a T24 cell line-derived xenograft model."	0.2586
41730444	International journal of biological macromolecules	2026	"Structure-guided engineering of modular RNA aptamer biosensors for one-pot, multiplex detection of CircRNAs."		circSLC38A1	hsa_circ_SLC38A1	SLC38A1	bladder cancer	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"This study used circSLC38A1 as one of two bladder cancer-associated circRNA biomarkers to validate a modular fluorescent RNA aptamer biosensor. The platform detected circSLC38A1 with femtomolar sensitivity, supported one-pot multiplex detection with circSMARCA5, and showed higher tumor-tissue signals in a T24 cell line-derived xenograft model."	0.2586
41739298	Journal of molecular histology	2026	CircRNA_02540 alleviated the migration and ligament differentiation capacities of SM-MSCs suppressed by chronic inflammation via regulating miR-203a-3p/ZIC1 pathway.		circRNA_02540 			anterior cruciate ligament (ACL) injury 	MONDO:0021178	injury	down-regulated	RT-qPCR	"circRNA_02540 was down-regulated in TNF-alpha-induced chronic inflammatory conditions in human SM-MSCs. Its overexpression restored SM-MSC migration and ligament differentiation by sponging miR-203a-3p and increasing ZIC1 expression, suggesting a potential strategy to improve MSC function for ACL reconstruction."	0.593
41739298	Journal of molecular histology	2026	CircRNA_02540 alleviated the migration and ligament differentiation capacities of SM-MSCs suppressed by chronic inflammation via regulating miR-203a-3p/ZIC1 pathway.		circRNA_06629			chronic inflammation environment	MONDO:0021166	inflammatory disease	down-regulated	RT-qPCR	"circRNA_06629 was one of the candidate circRNAs tested in SM-MSCs under TNF-alpha-induced chronic inflammatory stimulation. The study reported decreased circRNA_06629 expression, but did not further investigate its mechanism or biological function."	0.1155
41746541	Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico	2026	Time- and dose-dependent regulation of circular RNAs in the response of triple-negative breast cancer cells to ionizing radiation.		circTP53	hsa_circ_TP53	TP53	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"circTP53 is up-regulated in irradiated TNBC cell lines in a dose-dependent manner and its expression parallels p53 phosphorylation. Bioinformatics analysis suggests that it may function as a ceRNA involved in p53, FOXO and AMPK signaling, with potential value as a radiosensitivity biomarker."	0.4375
41746541	Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico	2026	Time- and dose-dependent regulation of circular RNAs in the response of triple-negative breast cancer cells to ionizing radiation.		circFBXW7 	hsa_circ_FBXW7	FBXW7	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	circFBXW7 is progressively induced after irradiation in TNBC cells. Predicted miRNA interactions and pathway enrichment suggest that it may connect DNA damage response to MAPK/Ras growth signaling and may affect radiation treatment sensitivity.	0.329
41746541	Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico	2026	Time- and dose-dependent regulation of circular RNAs in the response of triple-negative breast cancer cells to ionizing radiation.		cir-cATAD2 	hsa_circ_ATAD2	ATAD2	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	down-regulated	RT-qPCR	circATAD2 is consistently suppressed after irradiation in TNBC cell lines. Its predicted miRNA targets and downstream pathway enrichment suggest involvement in ubiquitin-mediated proteolysis and multiple signaling pathways relevant to radiation response.	0.329
41746541	Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico	2026	Time- and dose-dependent regulation of circular RNAs in the response of triple-negative breast cancer cells to ionizing radiation.		circABCC1	hsa_circ_ABCC1	ABCC1	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"circABCC1 is induced after irradiation in TNBC cell lines, with cell line-specific timing. The study suggests that it may contribute to post-IR survival and oxidative stress tolerance, supporting its potential as part of a radiosensitivity biomarker panel."	0.279
41746541	Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico	2026	Time- and dose-dependent regulation of circular RNAs in the response of triple-negative breast cancer cells to ionizing radiation.		circADAM9	hsa_circ_ADAM9	ADAM9	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	circADAM9 is up-regulated after irradiation in TNBC cells. The authors interpret this as part of an adaptive response that may support DNA repair and survival after genotoxic stress.	0.279
41746541	Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico	2026	Time- and dose-dependent regulation of circular RNAs in the response of triple-negative breast cancer cells to ionizing radiation.		circFOXO3	hsa_circ_FOXO3	FOXO3	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	circFOXO3 shows gradual dose- and time-dependent upregulation after irradiation in all tested TNBC cell lines. The authors suggest that it may be part of a universal DNA damage response network and may reflect the magnitude of cellular stress.	0.279
41746541	Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico	2026	Time- and dose-dependent regulation of circular RNAs in the response of triple-negative breast cancer cells to ionizing radiation.		circNCOR1 	hsa_circ_NCOR1	NCOR1	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	circNCOR1 is gradually up-regulated after irradiation in all tested TNBC cell lines. The authors suggest it may be part of a universal DNA damage response signature and may relate to cell-cycle and replication-stress responses.	0.279
41746541	Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico	2026	Time- and dose-dependent regulation of circular RNAs in the response of triple-negative breast cancer cells to ionizing radiation.		circHIPK3 	hsa_circ_HIPK3	HIPK3	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	dysregulated	RT-qPCR	circHIPK3 shows radiation-responsive dysregulation with transient reduction in BT-20 and MDA-MB-468 cells but induction in MDA-MB-231 cells. This pattern highlights cell line-specific heterogeneity of TNBC circRNA responses to ionizing radiation.	0.279
41746541	Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico	2026	Time- and dose-dependent regulation of circular RNAs in the response of triple-negative breast cancer cells to ionizing radiation.		circUBAP2	hsa_circ_UBAP2	UBAP2	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	dysregulated	RT-qPCR	"circUBAP2 is dysregulated after irradiation, with transient reduction in BT-20 and MDA-MB-468 cells and progressive increase at high dose in MDA-MB-231 cells. Its behavior reflects TNBC cell line-specific heterogeneity in radiation response."	0.279
41746541	Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico	2026	Time- and dose-dependent regulation of circular RNAs in the response of triple-negative breast cancer cells to ionizing radiation.		circCCNB1 	hsa_circ_CCNB1	CCNB1	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	down-regulated	RT-qPCR	"circCCNB1 is mainly suppressed following irradiation, reaching low expression at 9 h, although a late induction exception occurs in MDA-MB-231 cells. The authors link its suppression to cell cycle arrest and DNA repair responses after radiation-induced DNA damage."	0.279
41748046	Cellular signalling	2026	Circ_0057105 promotes intrahepatic cholangiocarcinoma progression by sponging miR-1290 and regulating the MDM2/P53 pathway.	hsa_circ_0057105	circ_0057105	hsa_circ_PDK1	PDK1	intrahepatic cholangiocarcinoma 	MONDO:0003210	intrahepatic cholangiocarcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circ_0057105 is a PDK1-derived cytoplasmic circRNA that is significantly upregulated in ICC and is associated with aggressive clinicopathological features and poor survival. It promotes ICC proliferation, migration, invasion, tumor growth, and metastasis by sponging miR-1290 to upregulate MDM2, thereby enhancing P53 ubiquitination/degradation and inhibiting the P53 signaling pathway. LNP-mediated si-circ_0057105 delivery suppresses tumor growth in vivo, supporting circ_0057105 as a prognostic biomarker and therapeutic target."	0.9033
41759475	Journal of reproductive immunology	2026	circVEGFC strengthens high glucose-induced trophoblast cell inflammation and apoptosis.		circRNA vascular endothelial growth factor C	hsa_circ_VEGFC	VEGFC	Gestational diabetes mellitus 	MONDO:0005406	gestational diabetes	up-regulated	RT-qPCR	"In this study, circVEGFC was up-regulated in high glucose-induced HTR8/SVneo trophoblast cells used as an in vitro GDM model. circVEGFC promoted trophoblast cell apoptosis and inflammatory injury by sponging miR-30d-5p and increasing Caspase-3 expression through a ceRNA-dependent circVEGFC/miR-30d-5p/Caspase-3 axis."	0.5627
41759746	Neurotoxicology	2026	Sevoflurane aggravated neuroinflammation and oxidative stress in neonatal mice by modulating microglia phenotype via circRNA2092/miR-873a-5p/KEAP1.		circRNA 2092 			sevoflurane-induced neurotoxicity 	MONDO:0005527	toxic encephalopathy	up-regulated	RNA-seq	"circRNA2092 is up-regulated after repeated sevoflurane exposure in neonatal mice and acts as a key ceRNA-network component in sevoflurane-induced cognitive impairment. It interacts with miR-873a-5p to promote KEAP1 expression, thereby aggravating microglial oxidative stress, neuroinflammation, mitochondrial damage, and hippocampal dysfunction; circRNA2092 knockdown alleviates these neurotoxic effects."	0.5997
41764743	"Journal of immunology (Baltimore, Md. : 1950)"	2026	circACTR2 facilitates M1 macrophage activation and exacerbates renal inflammation in mice with chronic kidney disease via RUNX1/HuR/miR-9-5p.		circACTR2 	mmu_circ_ACTR2	ACTR2	chronic kidney disease 	MONDO:0005300	chronic kidney disease	up-regulated	RT-qPCR	circACTR2 is up-regulated in adenine-induced CKD mouse renal tissues and LPS-stimulated RAW264.7 macrophages. It promotes proinflammatory M1 macrophage polarization and renal inflammation by sponging miR-9-5p to increase RUNX1 and by binding HuR to stabilize RUNX1 mRNA; circACTR2 silencing shifts macrophages toward an M2 phenotype and alleviates renal injury.	0.763
41765310	Cellular signalling	2026	Intercellular transfer of circ_0017636 via exosomal vehicles overcomes glioblastoma chemoresistance through ARRB1-mediated signaling restoration.	hsa_circ_0017636		hsa_circ_SFMBT2	SFMBT2	glioblastoma 	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR; RNA-seq	"circ_0017636 is a downregulated tumor-suppressive circRNA in GBM and TMZ-resistant GBM. It reverses TMZ resistance and suppresses malignant phenotypes by sponging miR-665 to restore ARRB1 expression, and exosome-mediated delivery of circ_0017636 propagates chemosensitivity and inhibits xenograft tumor growth. Low circ_0017636 expression is associated with poorer overall survival, while its expression shows diagnostic potential for GBM."	0.863
41765878	Molecular cancer	2026	IGF2BP3 promotes progression of head and neck cancers through the circHECTD2/hsa_miR_4310/7157-5p/Smad2 signaling axis in an m6A modification-dependent manner.	hsa_circ_0007168	circHECTD2 	hsa_circ_HECTD2	HECTD2	head and neck squamous cell carcinoma 	MONDO:0010150	head and neck squamous cell carcinoma	up-regulated	RT-qPCR; Northern Blot; ISH; RNA-seq	"circHECTD2 is an up-regulated, oncogenic circRNA in HNSCC. IGF2BP3 binds and stabilizes m6A-modified circHECTD2, and circHECTD2 promotes HNSCC proliferation, invasion, migration, and metastasis by sponging hsa-miR-4310 and hsa-miR-7157-5p to increase SMAD2 expression. High circHECTD2 expression is associated with worse prognosis and adverse clinicopathological features."	0.8983
41770666	Journal of visualized experiments : JoVE	2026	Circular RNA ZBTB46 Attenuates Apoptosis and Oxidative Stress in Lipopolysaccharide-Injured Human Endothelial Cells by Modulating ERBB2-AKT Signaling.		circular RNA ZBTB46 	hsa_circ_ZBTB46	ZBTB46	sepsis-related acute kidney injury 	MONDO:0005229	bacterial infectious disease with sepsis	down-regulated	RT-qPCR	"In an LPS-induced HUVEC model of sepsis-associated acute kidney injury, circZBTB46 was down-regulated and its overexpression protected endothelial cells from injury. It increased cell viability, reduced apoptosis, inflammatory cytokine release and oxidative stress, and acted through ERBB2-AKT pathway activation; ERBB2 inhibition weakened these protective effects."	0.5089
41772774	Journal of the Chinese Medical Association : JCMA	2026	Tumor-suppressive circRNAs in colorectal cancer spheroids and patients.	hsa_circ_0039776				colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RNA-seq	"hsa_circ_0039776 was identified as a potential tumor-suppressive circRNA that is reduced in CRC spheroids and metastatic lesions, with stepwise loss from normal mucosa to primary CRC and hepatic metastases. The study proposes that it acts through a circRNA-miRNA-mRNA network, especially the hsa_circ_0039776-hsa-miR-645-EFNA5 axis, to modulate CRC progression and cancer stemness."	0.5746
41772774	Journal of the Chinese Medical Association : JCMA	2026	Tumor-suppressive circRNAs in colorectal cancer spheroids and patients.	hsa_circ_0067353				colorectal cancer 	MONDO:0005575	colorectal cancer	down-regulated	RNA-seq	"hsa_circ_0067353 was identified as a potential tumor-suppressive circRNA downregulated in CRC spheroid models and liver metastatic tissues. The study places it in a predicted circRNA-miRNA-mRNA network involving oncogenic miRNAs and tumor-suppressive genes associated with cancer stemness, differentiation, apoptosis-related processes, and CRC progression."	0.5746
41776633	Molecular cancer	2026	m6A-dependent translation of circPICALM encodes a novel metastasis-promoting oncoprotein in intrahepatic cholangiocarcinoma.	hsa_circ_0002884	circRNA PICALM (circPICALM) 	hsa_circ_PICALM	PICALM	intrahepatic cholangiocarcinoma 	MONDO:0003210	intrahepatic cholangiocarcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circPICALM is a human PICALM-derived circRNA that is upregulated in recurrent and metastatic ICC and predicts poor OS and RFS. Its m6A/YTHDC1-dependent biogenesis and DDX3-regulated IRES-dependent translation produce circPICALM-219aa, which promotes ICC migration, invasion, and metastasis by antagonizing SOCS3 and sustaining IL-6/JAK/STAT3 signaling."	0.9032
41779432	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2026	Mechanism of CircBbs9 in Lung Epithelial Cell Ferroptosis in Lipopolysaccharide-Induced Acute Lung Injury.	hsa_circ_0079812	CircBbs9	hsa_circ_BBS9	Bbs9	acute lung injury 	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR	"CircBbs9 is up-regulated in LPS-induced acute lung injury mouse and lung epithelial cell models. It promotes ferroptosis and inflammatory lung injury by binding HuR to reduce Cblb mRNA stability and ACSL4 ubiquitination/degradation, and by sponging miR-671-5p to increase ACSL4 expression. Knockdown of CircBbs9 alleviates lung tissue injury, reduces ferroptosis markers, and improves lung epithelial cell viability."	0.7998
41782031	Journal of translational medicine	2026	Scutellarin mediates cell cycle arrest and apoptosis in liver cancer through a novel circSRBD1/miR-2682-5p/ESR1 ceRNA axis.	hsa_circ_0000997	circSRBD1 	hsa_circ_SRBD1	SRBD1	liver cancer	MONDO:0002691	liver cancer	up-regulated	RT-qPCR; RNA-seq	"circSRBD1 is up-regulated in liver cancer cell lines relative to normal hepatocyte controls and is downregulated by SCU treatment. It acts as a ceRNA sponge for miR-2682-5p to maintain ESR1 expression, thereby attenuating SCU-induced cell cycle arrest, apoptosis, and proliferation suppression. Knockdown of circSRBD1 enhances the anti-liver cancer effects of SCU."	0.8215
41785386	Acta cardiologica	2026	Dysregulation of serum hsa_circ_0005870 serves as a biomarker to predict disease onset and short-term prognosis in acute coronary syndrome patients.	hsa_circ_0005870				acute coronary syndrome 	MONDO:0005542	acute coronary syndrome	down-regulated	RT-qPCR	"In this study, serum hsa_circ_0005870 was down-regulated in SCHD and ACS, with a stronger reduction in ACS, and showed diagnostic value for ACS and prognostic value for short-term MACE risk. Functionally, hsa_circ_0005870 promoted endothelial cell viability/proliferation, inhibited apoptosis, reduced ED-associated adhesion molecules, and acted through the miR-127-3p/CDH1 regulatory axis."	0.7483
41794238	International journal of biological macromolecules	2026	CircRNA SLAIN1 is associated with reduced malignancy progression of glioblastoma and the M2-like polarization of tumor-associated macrophages via miR-1225-3p/NLRX1 axis.	hsa_circ_0000497	circSLAIN1 	hsa_circ_SLAIN1	SLAIN1	Glioblastoma 	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR; ISH; Microarray	"circSLAIN1 (hsa_circ_0000497) is down-regulated in GBM and higher expression is associated with better overall survival. Functionally, circSLAIN1 suppresses GBM cell proliferation, migration, invasion, EMT-related features and M2-like TAM polarization while promoting apoptosis. Mechanistically, it acts as a cytoplasmic ceRNA sponge for miR-1225-3p to upregulate NLRX1, suggesting prognostic biomarker and therapeutic target potential."	0.8991
41794277	Cancer letters	2026	circPLEKHM1 promotes tumor growth and metastasis through enhancing FXR1-mediated protein translation in PDAC.	hsa_circ_0044177		hsa_circ_PLEKHM1	PLEKHM1	pancreatic ductal adenocarcinoma 	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circPLEKHM1 is a human PLEKHM1-derived circRNA that is significantly up-regulated in PDAC tissues and serum. It promotes PDAC proliferation, migration, invasion, tumor growth, and metastasis by binding FXR1, blocking TRIM56-mediated FXR1 degradation, and enhancing FXR1-mediated global protein synthesis. Clinically, high circPLEKHM1 expression is associated with poor prognosis and serum circPLEKHM1 improves PDAC diagnostic performance, particularly in combination with CA19-9."	0.905
41796442	Journal of biochemical and molecular toxicology	2026	Curcumin Modulates 5-fluorouracil Sensitivity in Colorectal Cancer Cells Through the circ-NRIP1/miR-195-5p/SMURF1/AKT Signaling Axis.		Circular RNA Nuclear Receptor Interaction Protein 1 	hsa_circ_NRIP1	NRIP1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"In CRC cells, circ-NRIP1 is up-regulated and functions as a pro-malignant circRNA that promotes clonogenicity, migration and invasion while reducing sensitivity to 5-FU. Curcumin downregulates circ-NRIP1, thereby strengthening miR-195-5p-mediated inhibition of SMURF1, suppressing AKT pathway activation, promoting apoptosis, and enhancing 5-FU sensitivity."	0.6542
41810927	Analytical cellular pathology (Amsterdam)	2026	Regulation of Cell Function and Myeloid-Derived Suppressor Cell Chemotaxis by hsa_circ_0006466-miR-1286-PDGFRA/B Axis in Triple Negative Breast Cancer.	hsa_circ_0006466	hsa_-circ_0006466 	hsa_circ_UBQLN1	UBQLN1	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0006466 is upregulated in TNBC and positively correlates with MDSC abundance. It functions as a ceRNA that sponges miR-1286 to increase PDGFRA/PDGFRB expression, thereby promoting TNBC cell proliferation, migration, invasion and MDSC-mediated immune suppression. The study suggests that targeting this axis may provide a therapeutic strategy for TNBC."	0.6996
41812494	Molecular immunology	2026	m_A-modified circMELK regulates nasopharyngeal carcinoma progression via a YTHDF1/circMELK-miR-4775-HMGA2 feedback loop.	hsa_circ_0138742	circMELK 	hsa_circ_MELK	MELK	nasopharyngeal carcinoma 	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	Microarray	"circMELK is an upregulated oncogenic circRNA in nasopharyngeal carcinoma. It promotes proliferation, migration, invasion, EMT, tumor growth, and metastasis while suppressing apoptosis through an m6A-dependent YTHDF1/circMELK-miR-4775-HMGA2 positive feedback loop."	0.7907
41825439	Developmental cell	2026	CircRNA-encoded RIPK1-98 protein drives lung adenocarcinoma progression.		circRIPK1 	hsa_circ_RIPK1	RIPK1	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"CircRIPK1 is a human protein-coding circRNA upregulated during LUAD progression. It encodes RIPK1-98 through an m6A/YTHDF3/EIF4G2-dependent mechanism, promoting CDK2-driven cell-cycle progression, tumor growth, and osimertinib resistance, and it has potential as a peripheral blood biomarker of LUAD progression."	0.8972
41825439	Developmental cell	2026	CircRNA-encoded RIPK1-98 protein drives lung adenocarcinoma progression.		circGCN1	hsa_circ_GCN1	GCN1	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"CircGCN1 is a human circ-cUEP candidate upregulated during LUAD progression. The study supports a role in promoting LUAD cell proliferation and suggests utility as a peripheral blood biomarker when combined with circRIPK1 and circOGDH, although its detailed downstream mechanism was not resolved."	0.6987
41825439	Developmental cell	2026	CircRNA-encoded RIPK1-98 protein drives lung adenocarcinoma progression.		circOGDH 	hsa_circ_OGDH	OGDH	lung adenocarcinoma 	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"CircOGDH is a human circ-cUEP candidate upregulated during LUAD progression. The study supports a role in promoting LUAD cell proliferation and suggests utility as a peripheral blood biomarker when combined with circRIPK1 and circGCN1, although its detailed downstream mechanism was not resolved."	0.6987
41826685	Nature microbiology	2026	HIV-1-encoded circular RNA enhances viral transcription through Tat binding.		circHIV 			HIV-1 infection 	MONDO:0005109	HIV infectious disease	up-regulated	RT-qPCR; Northern Blot; RNA-seq	"CircHIV is an HIV-1-encoded circular RNA detected in infected cells, virions, primary CD4_ T cells, and plasma from people living with HIV-1. It promotes HIV-1 replication by enhancing viral transcription from the HIV-1 LTR, mainly through direct binding to the HIV-1 Tat protein. The study suggests that circHIV represents a previously unrecognized viral RNA regulator and a potential antiviral target."	0.8557
41837881	Molecular cancer research : MCR	2026	SF3B4-QKI splicing complex generates circ-FNDC3B and mediates breast cancer inhibition.	hsa_circ_0006156	Circ-FNDC3B 	hsa_circ_FNDC3B	FNDC3B	breast cancer 	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; RNA-seq	"Circ-FNDC3B is a human FNDC3B-derived circRNA that is down-regulated in breast cancer, especially in cases with lymph node metastasis. It suppresses breast cancer progression by binding PC and inhibiting its activity, thereby reducing aspartate and NADPH production, increasing ROS accumulation, promoting apoptosis, and inhibiting proliferation, invasion and metastasis. Its expression is clinically associated with tumor diameter, clinical stage and lymph node metastasis, suggesting biomarker potential."	0.8769
41843036	Digestive diseases and sciences	2026	"CircRSF1 Promoted HepG2 Cell Proliferation, Migration and Invasion Depending on EIF4A3."	hsa_circ_0096491	circRSF1	hsa_circ_RSF1	RSF1	hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circRSF1 (hsa_circ_0096491) is up-regulated in HCC tissues and IL-1beta-treated HepG2 cells. It promotes HepG2 proliferation, migration, invasion and xenograft tumor growth by interacting with the RNA-binding protein EIF4A3, which stabilizes circRSF1. The study suggests circRSF1 may act as an oncogenic mediator of inflammation-associated HCC progression and a potential therapeutic target."	0.8107
41845440	Cell communication and signaling : CCS	2026	Decoding the circRNA-miRNA-mRNA regulatory network in hepatitis B virus-driven hepatocellular carcinoma.		circADGRL2	hsa_circ_ADGRL2	ADGRL2	hepatitis B virus-driven hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circADGRL2 was one of the most strongly upregulated circRNAs in HBV-integrated Hep3B cells compared with HBV-negative HepG2 cells. The study proposes that circADGRL2 participates in a ceRNA network by sponging miR-361-5p and potentially increasing downstream targets such as BDNF and TGFB1, with possible biomarker relevance for HBV-HCC."	0.4761
41845440	Cell communication and signaling : CCS	2026	Decoding the circRNA-miRNA-mRNA regulatory network in hepatitis B virus-driven hepatocellular carcinoma.		circPROX1	hsa_circ_PROX1	PROX1	hepatitis B virus-driven hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	circPROX1 was included in the validated upregulated circRNA set and emerged as one of the key predicted ceRNA-network circRNAs. It was predicted to interact with miR-361-5p and to potentially enhance downstream targets such as BDNF and TGFB1 in HBV-HCC-related signaling.	0.4761
41845440	Cell communication and signaling : CCS	2026	Decoding the circRNA-miRNA-mRNA regulatory network in hepatitis B virus-driven hepatocellular carcinoma.		circPALS2	hsa_circ_PALS2	PALS2	hepatitis B virus-driven hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	circPALS2 was significantly upregulated in HBV-integrated Hep3B cells and was included among the validated circRNAs. Bioinformatic analysis predicted that circPALS2 interacts with miR-361-5p and may participate in the broader ceRNA network in HBV-HCC.	0.4761
41845440	Cell communication and signaling : CCS	2026	Decoding the circRNA-miRNA-mRNA regulatory network in hepatitis B virus-driven hepatocellular carcinoma.		circRNF220	hsa_circ_RNF220	RNF220	hepatitis B virus-driven hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circRNF220 was one of the selected and experimentally validated upregulated circRNAs in HBV-integrated Hep3B cells. The paper confirms its dysregulated expression and back-splice junction but does not define a specific miRNA, mRNA, pathway, or clinical role for circRNF220."	0.437
41845440	Cell communication and signaling : CCS	2026	Decoding the circRNA-miRNA-mRNA regulatory network in hepatitis B virus-driven hepatocellular carcinoma.		circNSD2 	hsa_circ_NSD2	NSD2	hepatitis B virus-driven hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circNSD2, also named circWHSC1, was significantly upregulated and validated as a bona fide circRNA in HBV-integrated Hep3B cells. Although prior oncogenic roles in HCC are mentioned, this study mainly provides expression and back-splice validation rather than a new circNSD2-specific mechanistic validation."	0.437
41845440	Cell communication and signaling : CCS	2026	Decoding the circRNA-miRNA-mRNA regulatory network in hepatitis B virus-driven hepatocellular carcinoma.		circSPECC1L	hsa_circ_SPECC1L	SPECC1L	hepatitis B virus-driven hepatocellular carcinoma 	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circSPECC1L was included among analyzed upregulated validated circRNAs in the ceRNA workflow. It was predicted to associate with miR-423-5p, and the corresponding target mRNA distribution suggested potential derepression of downstream targets in HBV-integrated Hep3B cells."	0.4761
41854883	Apoptosis : an international journal on programmed cell death	2026	The circTIMP2/miR-106a/TIMP2 tumor-suppressive axis versus tumor-derived exosomal counteraction in gastric cancer.	hsa_circ_0045943	circTIMP2 	hsa_circ_TIMP2	TIMP2	gastric cancer	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"circTIMP2 is downregulated in gastric cancer and functions as a tumor suppressor. It sponges miR-106a to relieve repression of TIMP2, thereby inhibiting Wnt/beta-catenin signaling, EMT, proliferation, migration, invasion, angiogenesis and tumor growth while promoting apoptosis. Tumor-derived exosomes can counteract this protective circTIMP2/miR-106a/TIMP2 axis and promote tumor progression."	0.8175
41857479	CNS neuroscience & therapeutics	2026	Exosome-Loaded Engineered circBDNF Promotes Spinal Cord Injury Repair Through the PI3K/AKT/mTOR Signaling Axis.		circBDNF		BDNF	spinal cord injury 	MONDO:0043797	spinal cord injury	unknown	RT-qPCR	"This study engineered a synthetic circular BDNF RNA, packaged it into exosomes, and tested it as a therapeutic agent for spinal cord injury. circBDNF-EXO increased BDNF production, activated TrkB and PI3K/AKT/mTOR signaling, reduced apoptosis, oxidative stress and inflammation, and promoted neuronal survival, axonal regeneration, and motor recovery."	0.6323
41860006	Mediators of inflammation	2026	Hsa_circ_0000313/miR-1224-3p/MKNK2 Axis Modulates CD4+ T Cells by Activating p38 MAPK Signaling in Myasthenia Gravis.	hsa_circ_0000313		hsa_circ_FADS2	FADS2	Myasthenia gravis 	MONDO:0009688	myasthenia gravis	up-regulated	RT-qPCR; Microarray	"This study found that hsa_circ_0000313 is upregulated in PBMCs/peripheral blood from MG patients. Mechanistically, cytoplasmic hsa_circ_0000313 sponges miR-1224-3p to increase MKNK2 expression and activate p38 MAPK signaling, promoting Jurkat cell proliferation and inflammatory cytokine secretion while suppressing apoptosis. Knockdown of hsa_circ_0000313 ameliorated LPS-induced inflammatory responses in Jurkat cells, suggesting potential therapeutic relevance in MG."	0.8095
41861993	The Journal of biological chemistry	2026	CircNOLC1/KRT16 Promotes Colorectal Cancer Invasion and Migration via c-Met Nuclear Translocation and Reprogramming of the Oxidative Pentose Phosphate Pathway.		circular RNA NOLC1 	hsa_circ_NOLC1	NOLC1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circNOLC1 acts as a pro-metastatic circRNA in colorectal cancer by directly binding KRT16 and enhancing KRT16 protein stability. The circNOLC1/KRT16 complex upregulates the c-Met/G6PD axis, maintains oxidative pentose phosphate pathway activity, and promotes colon cancer cell invasion and migration."	0.657
41862194	Zeitschrift fur Gastroenterologie	2026	"A comprehensive analysis of the circRNA, miRNA, and mRNA networks reveals prognostic biomarkers for gastric cancer."	hsa_circ_0007094				Gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	hsa_circ_0007094 was identified as an up-regulated circRNA in gastric cancer and validated by RT-qPCR in clinical tissues. It was included in a predicted circRNA-miRNA-mRNA prognostic ceRNA subnetwork associated with GC progression and prognosis.	0.5047
41862194	Zeitschrift fur Gastroenterologie	2026	"A comprehensive analysis of the circRNA, miRNA, and mRNA networks reveals prognostic biomarkers for gastric cancer."	hsa_circ_0004228	hsa_circ_004228 			Gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0004228 was up-regulated in gastric cancer tissues and cell lines. Knockdown experiments showed that it promotes GC cell activity, proliferation, migration, and invasion, likely through a predicted ceRNA mechanism involving tumor-suppressive miRNAs and downstream mRNAs."	0.6719
41862194	Zeitschrift fur Gastroenterologie	2026	"A comprehensive analysis of the circRNA, miRNA, and mRNA networks reveals prognostic biomarkers for gastric cancer."	hsa_circ_0007613		hsa_circ_PRRC2B	PRRC2B	Gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	hsa_circ_0007613 was identified and RT-qPCR-validated as up-regulated in gastric cancer tissues. It was included in the predicted prognostic ceRNA subnetwork together with prognostic mRNAs and candidate miRNAs.	0.5047
41862194	Zeitschrift fur Gastroenterologie	2026	"A comprehensive analysis of the circRNA, miRNA, and mRNA networks reveals prognostic biomarkers for gastric cancer."	hsa_circ_0008768	circ_ASAP2	hsa_circ_ASAP2	ASAP2	Gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	hsa_circ_0008768 was identified and RT-qPCR-validated as up-regulated in gastric cancer tissues. It was included in the predicted prognostic ceRNA subnetwork associated with gastric cancer progression and prognosis.	0.5047
41862194	Zeitschrift fur Gastroenterologie	2026	"A comprehensive analysis of the circRNA, miRNA, and mRNA networks reveals prognostic biomarkers for gastric cancer."	hsa_circ_0006089				Gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	hsa_circ_0006089 was identified and RT-qPCR-validated as up-regulated in gastric cancer tissues. It was included in the predicted prognostic ceRNA subnetwork associated with gastric cancer progression and prognosis.	0.5047
41862194	Zeitschrift fur Gastroenterologie	2026	"A comprehensive analysis of the circRNA, miRNA, and mRNA networks reveals prognostic biomarkers for gastric cancer."	hsa_circ_0007376				Gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	Microarray	hsa_circ_ 0007376 was identified from microarray data as one of the core up-regulated circRNAs in the predicted gastric cancer ceRNA regulatory network. No RT-qPCR validation or functional assay was reported for this circRNA.	0.1768
41862194	Zeitschrift fur Gastroenterologie	2026	"A comprehensive analysis of the circRNA, miRNA, and mRNA networks reveals prognostic biomarkers for gastric cancer."	hsa_circ_0004339				Gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	Microarray	hsa_circ_0004339 was identified from microarray data as one of the core up-regulated circRNAs in the predicted gastric cancer ceRNA regulatory network. No RT-qPCR validation or functional assay was reported for this circRNA.	0.1768
41862194	Zeitschrift fur Gastroenterologie	2026	"A comprehensive analysis of the circRNA, miRNA, and mRNA networks reveals prognostic biomarkers for gastric cancer."	hsa_circ_0003192				Gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	Microarray	hsa_-circ_0003192 was identified from microarray data as one of the core up-regulated circRNAs in the predicted gastric cancer ceRNA regulatory network. No RT-qPCR validation or functional assay was reported for this circRNA.	0.1768
41862194	Zeitschrift fur Gastroenterologie	2026	"A comprehensive analysis of the circRNA, miRNA, and mRNA networks reveals prognostic biomarkers for gastric cancer."	hsa_circ_0088485				Gastric cancer 	MONDO:0001056	gastric cancer	up-regulated	Microarray	hsa_circ_0088485 was identified from microarray data as one of the core up-regulated circRNAs in the predicted gastric cancer ceRNA regulatory network. No RT-qPCR validation or functional assay was reported for this circRNA.	0.1768
41863473	"Endocrine, metabolic & immune disorders drug targets"	2026	From Limited Samples to Mechanistic Insights: Exploratory Identification and Functional Validation of a hsa_circ_0062400/hsa_circ_0002397-miR-338-3p-NRP1 Axis in Myasthenia Gravis.	hsa_circ_0062400				Myasthenia Gravis 	MONDO:0009688	myasthenia gravis	up-regulated	Microarray	"hsa_circ_0062400 was identified as an upregulated circRNA in MG samples and was functionally validated in Jurkat cells. It appears to promote NRP1 expression and Jurkat cell proliferation by sponging miR-338-3p, implicating a hsa_circ_0062400/miR-338-3p/NRP1 ceRNA axis in MG pathogenesis."	0.6676
41863473	"Endocrine, metabolic & immune disorders drug targets"	2026	From Limited Samples to Mechanistic Insights: Exploratory Identification and Functional Validation of a hsa_circ_0062400/hsa_circ_0002397-miR-338-3p-NRP1 Axis in Myasthenia Gravis.	hsa_circ_0002397				Myasthenia Gravis 	MONDO:0009688	myasthenia gravis	up-regulated	Microarray	"hsa_circ_0002397 was identified as an upregulated circRNA in MG samples and was functionally validated in Jurkat cells. It appears to promote NRP1 expression and Jurkat cell proliferation by sponging miR-338-3p, implicating a hsa_circ_0002397/miR-338-3p/NRP1 ceRNA axis in MG pathogenesis."	0.6676
41863473	"Endocrine, metabolic & immune disorders drug targets"	2026	From Limited Samples to Mechanistic Insights: Exploratory Identification and Functional Validation of a hsa_circ_0062400/hsa_circ_0002397-miR-338-3p-NRP1 Axis in Myasthenia Gravis.	hsa_circ_0074332				Myasthenia Gravis 	MONDO:0009688	myasthenia gravis	up-regulated	Microarray	"hsa_circ_0074332 was identified from microarray data as an upregulated critical circRNA in MG and incorporated into a predicted circRNA-miRNA-mRNA ceRNA network. Unlike hsa_circ_0062400 and hsa_circ_0002397, no in vitro functional validation specific to hsa_circ_0074332 was reported."	0.348
41863473	"Endocrine, metabolic & immune disorders drug targets"	2026	From Limited Samples to Mechanistic Insights: Exploratory Identification and Functional Validation of a hsa_circ_0062400/hsa_circ_0002397-miR-338-3p-NRP1 Axis in Myasthenia Gravis.	hsa_circ_0004183				Myasthenia Gravis 	MONDO:0009688	myasthenia gravis	up-regulated	Microarray	hsa_circ_0004183 was identified from microarray data as an upregulated critical circRNA in MG and incorporated into a predicted circRNA-miRNA-mRNA ceRNA network. No in vitro functional validation specific to hsa_circ_0004183 was reported.	0.348
41870066	mBio	2026	Circular RNA circMagi1 regulates the host immune response in respiratory Pseudomonas aeruginosa infection through G3BP2.	hsa_circ_0066459	circMagi1 	hsa_circ_Magi1	Magi1	Pseudomonas aeruginosa lung infection 	MONDO:0040732	Pseudomonas aeruginosa infectious disease	down-regulated	RT-qPCR	"Human circMagi1, identified as hsa_circ_0066459, was significantly downregulated in BALF from patients with bacterial lung infection. The study proposes circMagi1 as a potential diagnostic biomarker and, based on conserved mouse functional studies, as a negative regulator of immune activation."	0.2995
41870066	mBio	2026	Circular RNA circMagi1 regulates the host immune response in respiratory Pseudomonas aeruginosa infection through G3BP2.	mmu_circ_0001496	circMagi1	mmu_circ_Magi1	Magi1	Pseudomonas aeruginosa lung infection 	MONDO:0040732	Pseudomonas aeruginosa infectious disease	down-regulated	RT-qPCR	"Mouse circMagi1, identified as mmu_circ_0001496, is downregulated in lung tissue after P. aeruginosa infection. It suppresses macrophage proinflammatory cytokine expression and maintains pulmonary immune homeostasis by binding G3BP2 and increasing G3BP2 protein stability through reduced K48-linked ubiquitination."	0.7595
41880676	International immunopharmacology	2026	Molecular mechanism of Circ_PRKDC regulating macrophage polarization in wound healing.		Circ_PRKDC 		PRKDC	wound healing 	MONDO:0021178	injury	down-regulated	RT-qPCR	"Circ_PRKDC is decreased during wound healing, and experimental overexpression delays mouse skin wound repair. Mechanistically, Circ_PRKDC binds FUS and reduces FUS-mediated stabilization of PRDX4 mRNA, lowering PRDX4 expression. This limits macrophage transition from M1 to M2, promotes a pro-inflammatory macrophage state, and suppresses skin cell healing and angiogenesis."	0.7951
41895673	Gene	2026	Circ_0068481 promotes pulmonary arterial smooth muscle cell remodeling via PTEN degradation and PI3K/AKT signaling activation.	hsa_circ_0068481	circ_0068481			pulmonary arterial hypertension 	MONDO:0015924	pulmonary arterial hypertension	up-regulated	RT-qPCR	"circ_0068481 is up-regulated in serum from PAH patients and in hypoxia-treated human pulmonary arterial smooth muscle cells. It promotes hPASMC proliferation, migration, survival, and phenotypic switching by associating with PTEN, enhancing PTEN ubiquitination and reducing PTEN protein abundance, which activates PI3K/AKT signaling."	0.8138
41896523	Cell death & disease	2026	CircIQGAP1-CARM1 axis promotes renal cell carcinoma progression through glycolytic reprogramming.	hsa_circ_0000651	circIQGAP1	hsa_circ_IQGAP1	IQGAP1	renal cell carcinoma 	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circIQGAP1 is an upregulated RCC-associated circRNA derived from IQGAP1 that promotes aerobic glycolysis, proliferation, migration, invasion, and xenograft tumor growth while suppressing apoptosis. Mechanistically, U2AF2 promotes circIQGAP1 biogenesis, and circIQGAP1 binds CARM1 to inhibit K48-linked ubiquitination, stabilize CARM1 protein, and activate COL5A1 transcription. Clinically, elevated circIQGAP1 in RCC tissues and plasma is associated with poorer prognosis and potential diagnostic/prognostic biomarker value."	0.8936
41902473	Acta biochimica et biophysica Sinica	2026	circ_0006156 promotes esophageal squamous cell carcinoma progression via activation of the TGFbeta/Smad pathway.	hsa_circ_0006156	circ_0006156	hsa_circ_FNDC3B	FNDC3B	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circ_0006156 (hsa_circ_0006156) is up-regulated in ESCC tissues and cell lines and high expression predicts poorer overall survival. Functionally, it promotes ESCC proliferation, migration, invasion, tumor growth and metastasis. Mechanistically, cytoplasmic circ_0006156 sponges miR-202-5p, relieves repression of TGFbetaR1, and activates TGFbeta/Smad signaling."	0.8862
41904925	Environment international	2026	CircRNA0052011 modulates DNA damage and repair via FEN1 ubiquitination to mitigate polystyrene nanoplastics-induced genotoxicity in the lung.	hsa_circ_0052011		hsa_circ_POLD1	POLD1	PS-NPs-induced DNA damage in the lung 	MONDO:0043905	pneumonitis	down-regulated	RT-qPCR; RNA-seq	"circRNA0052011 is downregulated after PS-NPs exposure in bronchial epithelial cells and mouse lung. It acts as a protective circRNA by directly binding FEN1, reducing FEN1 ubiquitination, stabilizing FEN1 protein, and promoting DNA repair to mitigate PS-NPs-induced genotoxicity and lung injury."	0.8335
41912059	Bone	2026	METTL3-mediated m6A modification of circWDR85 drives breast cancer bone metastasis via the CKB/c-Jun axis.	hsa_circ_0089696	circWDR85	hsa_circ_WDR85	WDR85	breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circWDR85 is an m6A-modified oncogenic circRNA up-regulated in highly metastatic breast cancer cells and bone metastatic tissues. METTL3 enhances circWDR85 biogenesis through m6A modification, and circWDR85 promotes osteolytic bone metastasis by recruiting CKB to phosphorylate and stabilize c-Jun."	0.7995
41912059	Bone	2026	METTL3-mediated m6A modification of circWDR85 drives breast cancer bone metastasis via the CKB/c-Jun axis.	hsa_circ_0058195				breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0058195 was included as a candidate circRNA from dysregulated circRNAs in breast cancer tissues with bone metastases. It showed higher expression in the highly metastatic SCP2 breast cancer subline, but no functional or mechanistic validation was reported."	0.1768
41912059	Bone	2026	METTL3-mediated m6A modification of circWDR85 drives breast cancer bone metastasis via the CKB/c-Jun axis.	hsa_circ_0006502				breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0006502 was included as a candidate circRNA from dysregulated circRNAs in breast cancer tissues with bone metastases. It showed higher expression in the highly metastatic SCP2 breast cancer subline, but no functional or mechanistic validation was reported."	0.1768
41912775	Oncogene	2026	Fusobacterium nucleatum drives colorectal cancer progression through the circPTBP3/miR-760/PUM1 axis.	hsa_circ_0003458	circPTBP3	hsa_circ_PTBP3	PTBP3	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"circPTBP3/hsa_circ_0003458 is a human PTBP3-derived circRNA upregulated in F. nucleatum-associated colorectal cancer. It promotes CRC proliferation, colony formation and xenograft tumor growth by sponging miR-760 and increasing PUM1 expression, while its induction is mediated by the transcription factor ETS1. Clinically, higher circPTBP3 expression correlates with F. nucleatum abundance, larger tumor size and advanced TNM stage, supporting its potential as a biomarker and therapeutic target."	0.8415
41916004	Biochemical and biophysical research communications	2026	Circ-ZBTB38 as an oncogenic circular RNA: Mechanisms in disrupting RalGAP complexes and its clinical value in melanoma.	hsa_circ_0067580	circ-ZBTB38 	hsa_circ_ZBTB38	ZBTB38	melanoma	MONDO:0005105	melanoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circ-ZBTB38 is a human ZBTB38-derived circular RNA that is up-regulated in melanoma tissues and cell lines. It acts as an oncogenic circRNA by binding RALGAPB, promoting its ubiquitination-mediated degradation, destabilizing RalGAP complexes, and hyperactivating Ral signaling, thereby promoting proliferation, migration, invasion, metastasis, and tumor growth. Clinically, high circ-ZBTB38 expression is associated with advanced stage and worse overall survival, supporting its value as a prognostic biomarker and therapeutic target."	0.8897
41940497	Virulence	2026	Novel_circ_002651 regulates the immune defense of eastern honeybee larvae against fungal invasion through sponging miR-6001-y.		novel_circ_002651 	ace_circ_LOC108001331	kinectin / LOC108001331	chalkbrood disease 	MONDO:0005583	non-human animal disease	down-regulated	RT-qPCR; RNA-seq	"In A. cerana worker larvae infected with A. apis, ac2651 is significantly down-regulated in larval guts and functions as a protective circRNA in antifungal immune defense. Mechanistically, ac2651 sponges ace-miR-6001-y to relieve repression of Ac14-3-3zeta, thereby modulating host immune genes and fungal proliferation-associated genes; ac2651 silencing lowers host survival and increases chalkbrood incidence."	0.7513
41950669	Translational oncology	2026	Single-cell transcriptomic analysis reveals that the circRNA circGCLM promotes tumorigenesis and confers cisplatin resistance in NSCLC through the miR-505-3p/ERBB4 axis.	hsa_circ_0003513	circGCLM	hsa_circ_GCLM	GCLM	non-small cell lung cancer 	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circGCLM (hsa_circ_0003513), derived from the GCLM gene, is upregulated in DDP-resistant NSCLC cells. It promotes proliferation, migration, tumor growth and cisplatin resistance while suppressing apoptosis, mainly through a ceRNA mechanism in which circGCLM sponges miR-505-3p to derepress ERBB4. Knockdown of circGCLM sensitizes resistant NSCLC cells and xenografts to DDP, suggesting therapeutic relevance for chemoresistant NSCLC."	0.8
41951890	Discover oncology	2026	CircTMCC1 enhances radioresistance in esophageal squamous cell carcinoma by upregulating MYC via miR-186-3p sponging.	hsa_circ_0001340	circTMCC1 	hsa_circ_TMCC1	TMCC1	esophageal squamous cell carcinoma 	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circTMCC1/hsa_circ_0001340 is up-regulated in ESCC, especially in radioresistant ESCC tissues, and promotes ESCC radioresistance in vitro and in vivo. Mechanistically, cytoplasmic circTMCC1 sponges miR-186-3p to increase MYC expression, reducing irradiation-induced gamma-H2AX and supporting resistance to radiotherapy. The study suggests the circTMCC1/miR-186-3p/MYC axis as a candidate target for ESCC radiosensitization."	0.8386
41952439	Clinical and translational medicine	2026	PVT1-104aa derived from the 8q24 gene desert promotes colorectal cancer tumorigenesis.	hsa_circ_0001821	circPVT1 	hsa_circ_PVT1	PVT1	colorectal cancer 	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circPVT1 is a PVT1-derived circRNA that is upregulated in colorectal cancer tissues and cell lines. Its oncogenic effect is mediated mainly through translation of PVT1-104aa, which stabilizes c-Myc by inhibiting GSK3beta/FBW7-associated ubiquitination and thereby increases PD-L1 expression, promoting tumor growth, metastasis, immune evasion, and poorer prognosis. PVT1-104aa inhibition enhances anti-PD-L1 treatment efficacy in syngeneic CRC models."	0.8976
41953107	Cytotechnology	2026	Prognostic value and cellular function of hsa_circ_0001588 in breast cancer.	hsa_circ_0001588				breast cancer 	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq; Microarray	"hsa_circ_0001588 is upregulated in breast cancer and is associated with advanced stage, lymph node involvement, distant metastasis, and poor survival. Functionally, it promotes proliferation, migration, invasion, and EMT by acting as a miR-525-3p sponge to relieve repression of KPNB1, making it a potential prognostic biomarker and therapeutic target."	0.7878
41960189	Frontiers in cell and developmental biology	2026	CircAFF3 modulation of p53-ID2 signaling in the retinal pigment epithelium links inflammation with cell death in dry age-related macular degeneration.			hsa_circ_AFF3	AFF3	dry age-related macular degeneration 	MONDO:0005150	age-related macular degeneration	down-regulated	RT-qPCR; RNA-seq	"circAFF3 is downregulated in RPE under dry AMD-related conditions and appears to act as a protective circRNA in RPE cells. Mechanistically, cytoplasmic circAFF3 directly binds p53 and modulates p53 stability, thereby maintaining ID2 expression and limiting oxidative stress, NF-kappaB-driven inflammation, apoptosis, and ferroptosis. The study suggests circAFF3 as a potential therapeutic target for dry AMD."	0.7595
41960189	Frontiers in cell and developmental biology	2026	CircAFF3 modulation of p53-ID2 signaling in the retinal pigment epithelium links inflammation with cell death in dry age-related macular degeneration.			mmu_circ_Aff3	Aff3	dry age-related macular degeneration 	MONDO:0005150	age-related macular degeneration	down-regulated	RT-qPCR; RNA-seq	"circAFF3 is downregulated in RPE under dry AMD-related conditions and appears to act as a protective circRNA in RPE cells. Mechanistically, cytoplasmic circAFF3 directly binds p53 and modulates p53 stability, thereby maintaining ID2 expression and limiting oxidative stress, NF-kappaB-driven inflammation, apoptosis, and ferroptosis. The study suggests circAFF3 as a potential therapeutic target for dry AMD."	0.7595
41964387	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2026	CircSTK40 Modulates the SETD1B/H3K4me2/H3K4me3 Loop to Regulate Recurrent Pregnancy Loss.		circSTK40 	hsa_circ_STK40	STK40	Recurrent pregnancy loss 	MONDO:0005047	infertility disorder	down-regulated	RT-qPCR	"circSTK40 is down-regulated in decidual tissue from RPL patients. In decidual cells, circSTK40 promotes SETD1B expression and H3K4 methylation by binding SETD1B and histone H3, thereby supporting decidual cell survival through inhibition of apoptosis and glycolysis and promotion of autophagy."	0.7571
41967697	Cancer letters	2026	Targeting the NSUN5-circPPAP2A axis reverses immunosuppression and sensitizes renal cell carcinoma to anti-PD-1 therapy.		circPPAP2A	hsa_circ_PPAP2A	PPAP2A	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"circPPAP2A is an up-regulated oncogenic circRNA in ccRCC. NSUN5-mediated m5C modification stabilizes circPPAP2A through YBX1, and circPPAP2A promotes YBX1 phosphorylation/nuclear translocation, HIF2A transcription, tumor progression, immune suppression, and anti-PD-1 resistance."	0.9001
41967697	Cancer letters	2026	Targeting the NSUN5-circPPAP2A axis reverses immunosuppression and sensitizes renal cell carcinoma to anti-PD-1 therapy.		circSOD2	hsa_circ_SOD2	SOD2	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"circSOD2 was identified as an up-regulated, NSUN5-regulated m5C-modified circRNA in ccRCC. The study did not further validate circSOD2-specific functional mechanisms beyond expression and m5C regulation."	0.413
41967697	Cancer letters	2026	Targeting the NSUN5-circPPAP2A axis reverses immunosuppression and sensitizes renal cell carcinoma to anti-PD-1 therapy.		circCHST15	hsa_circ_CHST15	CHST15	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"circCHST15 was identified as an up-regulated, NSUN5-regulated m5C-modified circRNA in ccRCC. The study did not further validate circCHST15-specific functional mechanisms beyond expression and m5C regulation."	0.413
41967697	Cancer letters	2026	Targeting the NSUN5-circPPAP2A axis reverses immunosuppression and sensitizes renal cell carcinoma to anti-PD-1 therapy.		circUSP48	hsa_circ_USP48	USP48	clear cell renal cell carcinoma 	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"circUSP48 was identified as an up-regulated, NSUN5-regulated m5C-modified circRNA in ccRCC. The study did not further validate circUSP48-specific functional mechanisms beyond expression and m5C regulation."	0.413
41967708	Journal of advanced research	2026	The deficiency of circSLC8A1 fosters tubular partial EMT-induced renal fibrosis through upregulating Annexin A2 signaling.	hsa_circ_0000994	circSlc8a1 	hsa_circ_SLC8A1 	SLC8A1	chronic kidney disease 	MONDO:0005300	chronic kidney disease	down-regulated	RT-qPCR; ISH; RNA-seq	"circSLC8A1/circSlc8a1 is a kidney-enriched circRNA downregulated in human CKD, TGF-beta-induced tubular epithelial cells, and UUO/UIRI renal fibrosis mouse models. Its loss promotes tubular partial EMT and fibrogenesis by stabilizing ANXA2 protein, whereas restoration of circSlc8a1 attenuates renal fibrosis in vivo. Clinically, lower circSLC8A1 expression correlates with worse kidney function, fibrosis severity and poor prognosis."	0.8892
41967708	Journal of advanced research	2026	The deficiency of circSLC8A1 fosters tubular partial EMT-induced renal fibrosis through upregulating Annexin A2 signaling.	mmu_circ_0000823	circSlc8a1 	mmu_circ_Slc8a1	SLC8A1	chronic kidney disease 	MONDO:0005300	chronic kidney disease	down-regulated	RT-qPCR; ISH; RNA-seq	"circSLC8A1/circSlc8a1 is a kidney-enriched circRNA downregulated in human CKD, TGF-beta-induced tubular epithelial cells, and UUO/UIRI renal fibrosis mouse models. Its loss promotes tubular partial EMT and fibrogenesis by stabilizing ANXA2 protein, whereas restoration of circSlc8a1 attenuates renal fibrosis in vivo. Clinically, lower circSLC8A1 expression correlates with worse kidney function, fibrosis severity and poor prognosis."	0.8892
41969469	Translational cancer research	2026	m6A modified circPTK2 mediates TNBC chemotherapy resistance.		circPTK2 	hsa_circ_PTK2	PTK2	triple-negative breast cancer 	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; Microarray	"circPTK2 is up-regulated in TNBC cisplatin-resistant cells, tissues, and plasma, and high expression is associated with DDP resistance and poor prognosis. Functionally, circPTK2 promotes chemoresistance, viability, and invasion, while knockdown enhances DDP-induced DNA damage and sensitivity. Mechanistically, m6A/YTHDC1-related circPTK2 acts through a miR-495/beta-catenin/Wnt signaling axis."	0.9018
41972134	Frontiers in immunology	2026	The molecular mechanism of circRNA_0021727 in inflammation of eosinophilic chronic rhinosinusitis.	hsa_circ_0021727	circRNA_0021727			eosinophilic chronic rhinosinusitis 	MONDO:0006031	chronic rhinosinusitis	up-regulated	RT-qPCR	"circRNA_0021727 is significantly up-regulated in nasal polyp tissues from ECRS patients. Functional experiments in primary nasal epithelial cells show that circRNA_0021727 promotes IL-13-associated inflammatory responses by suppressing miRNA_145_5p and increasing ADAM12 expression, thereby elevating GM-CSF, EOTAXIN, and MUC5AC. The study proposes circRNA_0021727 as a potential diagnostic marker and therapeutic target for ECRS."	0.5546
9261382	Journal of virology	1997	A 451-nucleotide circular RNA from cherry with hammerhead ribozymes in its strands of both polarities.		cherry small circular RNA (csc RNA1) 			cherry disease 	Plant diseases		unknown	RT-qPCR; Northern Blot	"This study characterized csc RNA1 as a 451-nucleotide circular RNA from cherry trees associated with cherry chlorotic rusty spot disease. csc RNA1 forms hammerhead ribozyme structures in both plus and minus strands, self-cleaves in vitro, accumulates in symptomatic tissue, and is proposed to be a new viroid-like satellite RNA associated with presumably viral dsRNAs."	0.329
38402995	Brain research bulletin	2024	Integrated analysis of circRNA- related ceRNA network targeting neuroinflammation in medial temporal lobe epilepsy.		mmu-Otulin_0005	mmu_circ_Otulin	Otulin	medial temporal lobe epilepsy 	MONDO:0005115	temporal lobe epilepsy	up-regulated	RT-qPCR	"mmu-Otulin_0005 was used as a mouse-derived homologous circRNA node in the mouse-specific hub ceRNA network. Its expression was significantly increased in the Sombati epilepsy cell model, supporting its involvement in the circRNA-miRNA-mRNA network associated with IL-1alpha-related neuroinflammatory regulation."	0.1768
35060299	Molecular oncology	2022	Digital multiplexed analysis of circular RNAs in FFPE and fresh non-small cell lung cancer specimens.		circFUT8	hsa_circ_FUT8	FUT8	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	Others	"circFUT8 is up-regulated in NSCLC FFPE tissues and in lung cancer cell lines based on nCounter profiling, and contributes to an ML-based diagnostic signature distinguishing NSCLC from controls. miRNA binding for circFUT8 was computationally predicted (including hsa-mir-186 and hsa-miR-1305), while a prior study is cited for a miR-944/YESI axis in NSCLC."	0.2629
35060299	Molecular oncology	2022	Digital multiplexed analysis of circular RNAs in FFPE and fresh non-small cell lung cancer specimens.	hsa_circ_0001640	circEPB41L2	hsa_circ_EPB41L2	EPB41L2	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"circEPB41L2 is down-regulated in NSCLC FFPE tissues, including early-stage cases, and is part of ML-based circRNA diagnostic signatures. Its predicted miRNA interactions include hsa-miR-942 (computational prediction), and the expression change was validated by RT-qPCR and junction-site Sanger sequencing in clinical FFPE samples."	0.6238
35060299	Molecular oncology	2022	Digital multiplexed analysis of circular RNAs in FFPE and fresh non-small cell lung cancer specimens.	hsa_circ_0086414	circBNC2	hsa_circ_BNC2	BNC2	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"circBNC2 is down-regulated in NSCLC FFPE tissues including early-stage disease, is included in ML diagnostic signatures, and its downregulation was validated by RT-qPCR and junction-site Sanger sequencing in clinical FFPE samples. A shared predicted miRNA binder across several signature circRNAs includes hsa-miR-942 (computational prediction)."	0.6238
35060299	Molecular oncology	2022	Digital multiplexed analysis of circular RNAs in FFPE and fresh non-small cell lung cancer specimens.	hsa_circ_0004777	circSOX13	hsa_circ_SOX13	SOX13	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"circSOX13 is down-regulated in NSCLC FFPE tissues including early-stage disease, is included in ML diagnostic signatures, and its downregulation was validated by RT-qPCR and junction-site Sanger sequencing in clinical FFPE samples. It was also reported to negatively correlate with smoking status in the lung cancer cohort, and is predicted to bind hsa-miR-942 (computational prediction)."	0.6238
35060299	Molecular oncology	2022	Digital multiplexed analysis of circular RNAs in FFPE and fresh non-small cell lung cancer specimens.		circCORO1C	hsa_circ_CORO1C	CORO1C+K8	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	unknown	Others	"circCORO1C is part of ML-derived circRNA signatures that classify NSCLC (including early-stage cases) versus controls using nCounter data, and its expression is reported to correlate with smoking status; however, its direction of differential expression in NSCLC versus controls is not explicitly stated in the provided text."	0.2629
35060299	Molecular oncology	2022	Digital multiplexed analysis of circular RNAs in FFPE and fresh non-small cell lung cancer specimens.		circCHD9	hsa_circ_CHD9	CHD9	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	Others	"circCHD9 is up-regulated in NSCLC FFPE tissues by nCounter profiling and appears in the 8-circRNA ML classification signature. A potential miRNA interaction (hsa-miR-1229) was predicted computationally, but no functional wet-lab mechanism validation was reported for this circRNA in this study."	0.2629
35060299	Molecular oncology	2022	Digital multiplexed analysis of circular RNAs in FFPE and fresh non-small cell lung cancer specimens.		circ_C1orf116	hsa_circ_C1ORF116	C1ORF116	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	Others	circC1ORF116 (also written as circ_C1orf116) is up-regulated in NSCLC FFPE tissues by nCounter profiling. No NSCLC-specific functional mechanism was experimentally validated in this study; discussion cites prior evidence in cervical cancer involving miR-518d-5p/miR-519-5p and BBX8.	0.0693
35060646	Journal of clinical laboratory analysis	2022	Circular RNA hsa_circ_0000285 regulates the microRNA-599/G-protein subunit gamma 12 (miR-599/GNG12) axis to promote glioma progression.	hsa_circ_0000285				glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"hsa_circ_0000285 is up-regulated in glioma tissues and cell lines. It promotes proliferation and migration and inhibits apoptosis, and it enhances xenograft tumor growth. Mechanistically, it functions as a ceRNA sponging miR-599, thereby relieving repression of GNG12."	0.7785
35060842	Emerging microbes & infections	2022	hnRNP C modulates MERS-CoV and SARS-CoV-2 replication by governing the expression of a subset of circRNAs and cognitive mRNAs.	hsa_circ_0002846		hsa_circ_RASAL2	RASAL2	coronavirus infectious disease	MONDO:0020753	Orthocoronavirinae infectious disease	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0002846 is upregulated during MERS-CoV infection and physically binds hnRNP C. Knockdown of hsa_circ_0002846 reduces MERS-CoV replication, supporting a proviral role; hnRNP C depletion also decreases hsa_circ_0002846 along with its cognate host gene RASAL2."	0.5803
35060842	Emerging microbes & infections	2022	hnRNP C modulates MERS-CoV and SARS-CoV-2 replication by governing the expression of a subset of circRNAs and cognitive mRNAs.	hsa_circ_0002061		hsa_circ_RASAL2	RASAL2	coronavirus infectious disease	MONDO:0020753	Orthocoronavirinae infectious disease	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0002061 is upregulated during MERS-CoV infection and binds hnRNP C. Silencing hsa_circ_0002061 reduces MERS-CoV replication, and hnRNP C knockdown lowers hsa_circ_0002061 and its cognate mRNA RASAL2, supporting an hnRNP C_circRNA regulatory mechanism relevant to coronavirus replication."	0.5803
35060842	Emerging microbes & infections	2022	hnRNP C modulates MERS-CoV and SARS-CoV-2 replication by governing the expression of a subset of circRNAs and cognitive mRNAs.	hsa_circ_0004445		hsa_circ_CRK	CRK	coronavirus infectious disease	MONDO:0020753	Orthocoronavirinae infectious disease	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0004445 (from CRK) is upregulated during MERS-CoV infection, binds hnRNP C, and its knockdown most strongly suppresses MERS-CoV replication among tested circRNAs. During SARS-CoV-2 infection, hnRNP C knockdown also diminishes hsa_circ_0004445 and CRK expression, linking this circRNA to an hnRNP C_CRK-associated proviral program."	0.5803
35061934	Clinical and translational medicine	2022	The novel role of circular RNA ST3GAL6 on blocking gastric cancer malignant behaviours through autophagy regulated by the FOXP2/MET/mTOR axis.	hsa_circ_0066608		hsa_circ_ST3GAL6	ST3GAL6	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; RNA-seq	"circST3GAL6 is down-regulated in gastric cancer and functions as a tumor suppressor. It sponges miR-300 to increase FOXP2, which transcriptionally represses MET and dampens AKT/mTOR signaling, thereby promoting autophagy and apoptosis and inhibiting proliferation and metastasis in vitro and in vivo."	0.8849
35062922	BMC medical genomics	2022	Genome-wide analysis of circular RNAs and validation of hsa_circ_0086354 as a promising biomarker for early diagnosis of cerebral palsy.	hsa_circ_0086354		hsa_circ_PTPRD	PTPRD	cerebral palsy / CP	MONDO:0006497	cerebral palsy	down-regulated	RT-qPCR; Microarray	"This study identifies hsa_circ_0086354 as significantly down-regulated in the plasma of children with cerebral palsy and supports its utility as an early diagnostic biomarker (AUC 0.967). Mechanistically, it is predicted to act as a ceRNA targeting miR-181a (and also miR-4741/miR-4656), with a negative correlation between hsa_circ_0086354 and miR-181a in CP plasma."	0.5047
35062989	Journal of orthopaedic surgery and research	2022	Circular RNA hsa_circ_0069117 suppresses proliferation and migration of osteosarcoma cells lines via miR-875-3p/PF4V1 axis.	hsa_circ_0069117		hsa_circ_TBC1D14	TBC1D14	osteosarcoma / OS	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; Microarray	"In osteosarcoma, hsa_circ_0069117 is down-regulated and functions as a tumor-suppressive circRNA. It sponges miR-875-3p to increase PF4V1, which in turn suppresses ERK1 and AKT signaling, leading to reduced proliferation and migration of OS cells."	0.6777
35063035	Diabetology & metabolic syndrome	2022	Circular RNA circZNF532 facilitates angiogenesis and inflammation in diabetic retinopathy via regulating miR-1243/CARM1 axis.	hsa_circ_0047814	circRNA zinc finger protein 532	hsa_circ_ZNF532	ZNF532	diabetic retinopathy / DR	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR	"circZNF532 is up-regulated in DR patient serum and in HG-stimulated hRMECs. It promotes endothelial dysfunction (proliferation, migration/invasion, tube formation, and inflammatory cytokine release) by acting as a ceRNA that sponges miR-1243 and thereby up-regulates CARM1."	0.7591
35064116	Cell death & disease	2022	Estrogen receptor beta promotes lung cancer invasion via increasing CXCR4 expression.	hsa_circ_0001130		hsa_circ_TMX4	TMX4	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"In NSCLC/lung cancer, circ-TMX4 (hsa_circ_0001130) is up-regulated and promotes invasion and in vivo metastatic progression. Mechanistically, ERbeta binds the TMX4 promoter to increase circ-TMX4, which sponges miR-622 and thereby increases CXCR4 translation to enhance invasive behavior."	0.841
35067172	Bioengineered	2022	Knockdown of circular RNA tousled-like kinase 1 relieves ischemic stroke in middle cerebral artery occlusion mice and oxygen-glucose deprivation and reoxygenation-induced N2a cell damage.		circular RNA tousled-like kinase 1	mmu_circ_TLK1	TLK1	ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR	"circTLK1 is upregulated in ischemic stroke models and aggravates neuronal injury. Mechanistically, circTLK1 sponges miR-26a-5p to increase PTEN and activate the downstream IGF-1 R/GLUT1 signaling, promoting apoptosis and reducing neuronal viability; circTLK1 knockdown alleviates these effects in MCAO mice and OGD/R-treated N2a cells."	0.7099
35068324	Bioengineered	2022	Silencing circular RNAPTPN12 promoted the growth of keloid fibroblasts by activating Wnt signaling pathway via targeting microRNA-21-5p.			hsa_circ_PTPN12	PTPN12	keloid	MONDO:0005348	keloid	down-regulated	RT-qPCR	"circPTPN12 is down-regulated in keloid tissues and keloid fibroblasts. Functionally, circPTPN12 acts as an inhibitory circRNA in keloid fibroblasts; its silencing promotes viability/proliferation, migration and invasion while reducing apoptosis via a ceRNA mechanism involving miR-21-5p and SMAD7, with downstream activation of Wnt signaling (e.g., cyclinD1 and c-myc)."	0.7277
35068326	Bioengineered	2022	Circ-CUL2/microRNA-888-5p/RB1CC1 axis participates in cisplatin resistance in NSCLC via repressing cell advancement.			hsa_circ_CUL2	CUL2	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"Circ-CUL2 is down-regulated in NSCLC and functions as a tumor-suppressive circRNA that reduces cisplatin resistance. Mechanistically, it negatively regulates miR-888-5p to increase RB1CC1 expression, and RB1CC1 knockdown reverses Circ-CUL2-mediated effects on NSCLC cell behaviors."	0.7126
35068339	Bioengineered	2022	Circular RNA Rbms1 inhibited the development of myocardial ischemia reperfusion injury by regulating miR-92a/BCL2L11 signaling pathway.		circRbms1	mmu_circ_Rbms1	Rbms1	acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR	"circRbms1 is up-regulated in myocardial I/R (AMI models). Silencing circRbms1 protects cardiomyocytes by reducing apoptosis and ROS, mainly through a ceRNA mechanism where circRbms1 sponges miR-92a to increase BCL2L11 expression."	0.7045
35068348	Bioengineered	2022	Circular RNA hsa_circ_0006091 as a novel biomarker for hepatocellular carcinoma.	hsa_circ_0006091		hsa_circ_RGS12	RGS12	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0006091 is up-regulated in HCC tissues and is detectable in serum, showing postoperative decline and recurrence-associated rebound. The study constructs a predicted circRNA_miRNA_mRNA network (4 miRNAs) and supports its use as a diagnostic/monitoring biomarker, with improved ROC performance when combined with AFP or RGS12."	0.6957
35069696	Frontiers in genetics	2021	CircACC1 Promotes NSCLC Proliferation via miR-29c-3p/MCL-1 Signaling Pathway.		circACC1	hsa_circ_ACC1	ACC1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circACC1 is upregulated in NSCLC tissues and cell lines and promotes NSCLC cell proliferation and clonogenicity. Mechanistically, circACC1 sponges miR-29c-3p to increase MCL-1 expression, forming a circACC1/miR-29c-3p/MCL-1 regulatory axis associated with poor overall survival."	0.7507
35069793	Computational and mathematical methods in medicine	2022	Circular RNA CCDC66 Improves Murine Double Minute 4 (MDM4) Expression through Targeting miR-370 in Colorectal Cancer.			hsa_circ_CCDC66	CCDC66	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circCCDC66 is up-regulated in colorectal cancer tissues and CRC cell lines and functions as an oncogenic circRNA. It mainly localizes to the cytoplasm, sponges miR-370, and thereby increases MDM4 expression, promoting CRC cell proliferation, migration, and invasion."	0.6777
35069901	Journal of Cancer	2022	CircRNA_400029 promotes the aggressive behaviors of cervical cancer by regulation of miR-1285-3p/TLN1 axis.	hsa_circ_0092337	circRNA_400029	hsa_circ_RPL13	RPL13	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; ISH	"circRNA_400029 is up-regulated in cervical cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes proliferation, migration, invasion and tumor growth while inhibiting apoptosis, acting as a ceRNA that sponges miR-1285-3p to de-repress TLN1."	0.7034
35070838	Translational pediatrics	2021	"CircRNA-ACAP2 contributes to the invasion, migration, and anti-apoptosis of neuroblastoma cells through targeting the miRNA-143-3p-hexokinase 2 axis."			hsa_circ_ACAP2	ACAP2	neuroblastoma	MONDO:0005072	neuroblastoma	up-regulated	RT-qPCR	"circRNA-ACAP2 is up-regulated in neuroblastoma tissues and cell lines and promotes migration, invasion and glycolysis while inhibiting apoptosis. Mechanistically, it sponges miR-143-3p to relieve repression of HK2, forming an ACAP2/miR-143-3p/HK2 axis that drives oncogenic phenotypes in vitro."	0.7032
35070947	Frontiers in oncology	2021	CircWHSC1 Promotes Breast Cancer Progression by Regulating the FASN/AMPK/mTOR Axis Through Sponging miR-195-5p.		CircWHSC1	hsa_circ_WHSC1	WHSC1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circWHSC1 is up-regulated in breast cancer and functions as an oncogenic circRNA. It sponges miR-195-5p to increase FASN, thereby inhibiting AMPK activation and enhancing mTOR signaling, promoting proliferation, migration/invasion, EMT, metastasis, and tumor growth; high circWHSC1 correlates with worse overall survival."	0.7793
35071227	Frontiers in cell and developmental biology	2021	Multi-Omics Characterization of Circular RNA-Encoded Novel Proteins Associated With Bladder Outlet Obstruction.		chr14:44496991|44498906			bladder outlet obstruction / BOO	MONDO:0006679	bladder neck obstruction	up-regulated	RT-qPCR; RNA-seq	"In a rat BOO model, circRNA chr14:44496991|44498906 is up-regulated in bladder tissues. It is an ORF-containing circRNA predicted to encode a novel protein, and its expression change was consistent between RNA-seq and RT-qPCR, with the encoded protein supported by proteomics/mass spectrometry."	0.5922
35071227	Frontiers in cell and developmental biology	2021	Multi-Omics Characterization of Circular RNA-Encoded Novel Proteins Associated With Bladder Outlet Obstruction.		chr1:259396273|259437470			bladder outlet obstruction / BOO	MONDO:0006679	bladder neck obstruction	down-regulated	RT-qPCR; RNA-seq	"In rat bladder tissues, circRNA chr1:259396273|259437470 is down-regulated in BOO. It is an ORF-containing circRNA predicted to encode a novel protein, with circRNA down-regulation validated by RT-qPCR and protein evidence supported by iTRAQ proteomics/mass spectrometry."	0.5922
35071227	Frontiers in cell and developmental biology	2021	Multi-Omics Characterization of Circular RNA-Encoded Novel Proteins Associated With Bladder Outlet Obstruction.		chr1:141877382|141880461			bladder outlet obstruction / BOO	MONDO:0006679	bladder neck obstruction	down-regulated	RT-qPCR; RNA-seq	"In rat BOO bladder tissues, circRNA chr1:141877382|141880461 is down-regulated. It is predicted to encode a novel protein (ORF spans junction) and is one of the five ORF-containing circRNAs whose expression change was validated by RT-qPCR and supported by proteomics/mass spectrometry evidence of the encoded protein."	0.5922
35071227	Frontiers in cell and developmental biology	2021	Multi-Omics Characterization of Circular RNA-Encoded Novel Proteins Associated With Bladder Outlet Obstruction.		chr9:81258380|81275269			bladder outlet obstruction / BOO	MONDO:0006679	bladder neck obstruction	down-regulated	RT-qPCR; RNA-seq	"In the rat BOO bladder, circRNA chr9:81258380|81275269 is down-regulated. It is an ORF-containing circRNA predicted to encode a novel protein; the circRNA level change was RT-qPCR validated and the encoded protein was supported by mass spectrometry within iTRAQ proteomics."	0.5922
35071227	Frontiers in cell and developmental biology	2021	Multi-Omics Characterization of Circular RNA-Encoded Novel Proteins Associated With Bladder Outlet Obstruction.		chr19:39176540|39195019			bladder outlet obstruction / BOO	MONDO:0006679	bladder neck obstruction	down-regulated	RT-qPCR; RNA-seq	"CircRNA chr19:39176540|39195019 is down-regulated in bladder tissues in a rat BOO model. It is predicted to encode a novel protein and is among the five ORF-containing circRNAs validated by RT-qPCR, with proteomic/mass spectrometric evidence supporting expression of its encoded protein."	0.5922
35071451	Annals of translational medicine	2021	Construction and analysis of the ceRNA network hsa_circ_0031968/miR-3611/GCG in lung adenocarcinoma.	hsa_circ_0031968				lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0031968 is down-regulated in LUAD tissues and was proposed to act in a ceRNA network by regulating miR-3611 to affect the target gene GCG. The study suggests this axis may contribute to LUAD pathogenesis and could provide biomarker clues, but the circRNA¡¯s predictive value requires further experimental validation."	0.4032
35072355	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2022	circVAMP3 Drives CAPRIN1 Phase Separation and Inhibits Hepatocellular Carcinoma by Suppressing c-Myc Translation.		circVAMP3	hsa_circ_VAMP3	VAMP3	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"circVAMP3 is significantly down-regulated in HCC tissues and low expression is associated with poor overall survival. Functionally, circVAMP3 suppresses HCC proliferation and metastasis by binding CAPRIN1, promoting CAPRIN1 phase separation and stress granule formation, thereby inhibiting c-Myc translation under stress conditions."	0.8781
35073911	Molecular cancer	2022	The circROBO1/KLF5/FUS feedback loop regulates the liver metastasis of breast cancer by inhibiting the selective autophagy of afadin.	hsa_circ_0124696	circROBO1	hsa_circ_ROBO1	ROBO1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circROBO1 is upregulated in breast cancer liver metastases and promotes breast cancer cell proliferation, migration/invasion, tumor growth, and liver metastasis. Mechanistically, circROBO1 sponges miR-217-5p to upregulate KLF5, which transcriptionally activates FUS to enhance circROBO1 back-splicing (positive feedback loop), and circROBO1/KLF5 suppresses BECN1 transcription to inhibit selective autophagy of afadin. High circROBO1 expression is associated with poor overall survival, suggesting prognostic and therapeutic potential."	0.8878
35075806	Clinical and translational medicine	2022	Circular CPM promotes chemoresistance of gastric cancer via activating PRKAA2-mediated autophagy.	hsa_circ_0027497	circular CPM / circ0027497	hsa_circ_CPM	CPM	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circCPM (circ0027497), derived from CPM, is up-regulated in 5-FU-resistant gastric cancer tissues/cells. It promotes 5-FU chemoresistance by sponging miR-21-3p in the cytoplasm, thereby increasing PRKAA2 expression and activating autophagy while reducing apoptosis, and its high expression correlates with poor survival."	0.8912
35076987	Thoracic cancer	2022	CircRNA PRH1-PRR4 stimulates RAB3D to regulate the malignant progression of NSCLC by sponging miR-877-5p.	hsa_circ_0000376	circ_000554	hsa_circ_PRH1-PRR4	PRH1_PRR4	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circPRH1-PRR4 is up-regulated in NSCLC tissues and cell lines and functions as an oncogenic circRNA. It sponges miR-877-5p to increase RAB3D expression, thereby promoting proliferation/migration/invasion and suppressing apoptosis, and its knockdown reduces tumor growth in a xenograft model."	0.7735
35078526	Genome medicine	2022	The transcriptional landscape and biomarker potential of circular RNAs in prostate cancer.		circABCC4	hsa_circ_ABCC4	ABCC4	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RNA-seq; Microarray	circABCC4 is up-regulated in prostate cancer tissue compared with adjacent-normal samples and shows cancer-specific diagnostic potential based on ROC analyses. The paper does not experimentally define its mechanism in this cohort.	0.5047
35078526	Genome medicine	2022	The transcriptional landscape and biomarker potential of circular RNAs in prostate cancer.		circZNF577	hsa_circ_ZNF577	ZNF577	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RNA-seq; Microarray	circZNF577 is up-regulated in prostate cancer versus adjacent-normal tissue and shows modest diagnostic performance (AUC ~0.64). No functional mechanism is established in this study.	0.5047
35078526	Genome medicine	2022	The transcriptional landscape and biomarker potential of circular RNAs in prostate cancer.		circFAT3	hsa_circ_FAT3	FAT3	prostate cancer / PCa	MONDO:0008315	prostate cancer	down-regulated	RNA-seq; Microarray	circFAT3 is markedly down-regulated in prostate cancer tissue and shows strong diagnostic potential (AUC up to 0.86 in validation). No direct functional mechanism is demonstrated in this study.	0.5047
35078526	Genome medicine	2022	The transcriptional landscape and biomarker potential of circular RNAs in prostate cancer.		circITGA7	hsa_circ_ITGA7	ITGA7	prostate cancer / PCa	MONDO:0008315	prostate cancer	down-regulated	RNA-seq; Microarray	"circITGA7 is down-regulated in prostate cancer tissue. Low circITGA7 expression predicts worse BCR-free outcomes (and is associated with progression to metastatic disease in RP cohort 3), suggesting potential tumor-suppressive relevance, though no mechanism is established here."	0.5734
35078526	Genome medicine	2022	The transcriptional landscape and biomarker potential of circular RNAs in prostate cancer.		circATRNL1	hsa_circ_ATRNL1	ATRNL1	prostate cancer / PCa	MONDO:0008315	prostate cancer	down-regulated	RNA-seq; Microarray	circATRNL1 is down-regulated in prostate cancer tissue and has diagnostic potential (AUC up to ~0.85 in validation). No mechanism is experimentally established in this study.	0.5047
35078526	Genome medicine	2022	The transcriptional landscape and biomarker potential of circular RNAs in prostate cancer.		circKMD1A	hsa_circ_KMD1A	KDM1A	prostate cancer / PCa	MONDO:0008315	prostate cancer	unknown	RNA-seq; Microarray	circKMD1A is one component of a 5-circRNA signature that was trained and validated to predict BCR after radical prostatectomy beyond routine clinicopathologic variables. The study does not define a molecular mechanism for circKMD1A.	0.5202
35078526	Genome medicine	2022	The transcriptional landscape and biomarker potential of circular RNAs in prostate cancer.		circTULP4	hsa_circ_TULP4	TULP4	prostate cancer / PCa	MONDO:0008315	prostate cancer	unknown	RNA-seq; Microarray	"circTULP4 is a prognostic circRNA in prostate cancer: higher expression associates with improved BCR-free survival in Cox regression, and it contributes to a validated 5-circRNA signature predicting BCR. No mechanistic experiments are reported."	0.5202
35078526	Genome medicine	2022	The transcriptional landscape and biomarker potential of circular RNAs in prostate cancer.		circZNF532	hsa_circ_ZNF532	ZNF532	prostate cancer / PCa	MONDO:0008315	prostate cancer	down-regulated	RNA-seq; Microarray	circZNF532 is down-regulated in metastatic versus localized prostate cancer and is included in a validated 5-circRNA signature predicting BCR after surgery. No mechanistic role is tested.	0.5202
35078526	Genome medicine	2022	The transcriptional landscape and biomarker potential of circular RNAs in prostate cancer.		circSUMF1	hsa_circ_SUMF1	SULF1	prostate cancer / PCa	MONDO:0008315	prostate cancer	unknown	RNA-seq; Microarray	circSUMF1 is included in a 5-circRNA prognostic signature that independently predicts biochemical recurrence after radical prostatectomy. The study does not test circSUMF1 mechanisms.	0.5202
35078526	Genome medicine	2022	The transcriptional landscape and biomarker potential of circular RNAs in prostate cancer.		circMKLN1	hsa_circ_MKLN1	MKLN1	prostate cancer / PCa	MONDO:0008315	prostate cancer	down-regulated	RNA-seq; Microarray	circMKLN1 is down-regulated in metastatic versus localized prostate cancer and is associated with biochemical recurrence endpoints; higher expression is linked to better BCR-free survival in Cox analyses. It is also part of a validated 5-circRNA prognostic signature.	0.5202
35078526	Genome medicine	2022	The transcriptional landscape and biomarker potential of circular RNAs in prostate cancer.		circN4BP2L2	hsa_circ_N4BP2L2	N4BP2L2	prostate cancer / PCa	MONDO:0008315	prostate cancer	down-regulated	RNA-seq; Microarray	circN4BP2L2 is significantly down-regulated in metastatic compared with localized prostate cancer and this difference is validated in an independent cohort. No functional mechanism is explored.	0.3588
35078526	Genome medicine	2022	The transcriptional landscape and biomarker potential of circular RNAs in prostate cancer.		circCDYL2	hsa_circ_CDYl2	CDYL2	prostate cancer / PCa	MONDO:0008315	prostate cancer	down-regulated	RNA-seq; Microarray	circCDYL2 is significantly down-regulated in metastatic compared with localized prostate cancer and is validated in an independent cohort. The study does not provide mechanistic data for circCDYL2.	0.3588
35078526	Genome medicine	2022	The transcriptional landscape and biomarker potential of circular RNAs in prostate cancer.		circARHGAP10	hsa_circ_ARHGAP10	ARHGAP10	prostate cancer / PCa	MONDO:0008315	prostate cancer	down-regulated	RNA-seq; Microarray	"circARHGAP10 is down-regulated in prostate cancer versus adjacent-normal tissue and further down-regulated in metastatic versus localized disease, with diagnostic ROC performance reported. No mechanistic studies are included."	0.4679
35078526	Genome medicine	2022	The transcriptional landscape and biomarker potential of circular RNAs in prostate cancer.		circACVR2A	hsa_circ_ACVR2A	ACVR2A	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	Microarray	"circACVR2A is detectable in EV-enriched plasma and is elevated in patients with metastatic prostate cancer compared with cancer-free controls, supporting potential as a minimally invasive biomarker. No mechanism is studied."	0.2995
35081862	Bioengineered	2022	Circular RNA_0033596 aggravates endothelial cell injury induced by oxidized low-density lipoprotein via microRNA-217-5p /chloride intracellular channel 4 axis.	hsa_circ_0033596		hsa_circ_PACS2	PACS2	atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"In an ox-LDL_induced HUVEC in-vitro atherosclerosis injury model, circ_0033596 is up-regulated and promotes endothelial injury by reducing viability/cell-cycle progression and increasing apoptosis. Mechanistically, it sponges miR-217-5p to relieve repression of CLIC4, forming a circ_0033596/miR-217-5p/CLIC4 regulatory axis."	0.5925
35081867	Bioengineered	2022	Circular RNA lysophosphatidic acid receptor 3 (circ-LPAR3) enhances the cisplatin resistance of ovarian cancer.	hsa_circ_0004390		hsa_circ_LPAR3	LPAR3	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circ-LPAR3 is upregulated in cisplatin-resistant ovarian cancer tissues and resistant cell lines. It promotes cisplatin resistance by acting as a ceRNA for miR-634, increasing PDK1 expression and enhancing glycolysis, thereby supporting proliferation and metastasis-related behaviors and suppressing apoptosis."	0.7228
35081869	Bioengineered	2022	Hsa_circ_0006677 regulates special AT-rich binding protein-2-mediated tumor-suppressive effect via functioning as a miR-1245a sponge in non-small cell lung cancer.	hsa_circ_0006677		hsa_circ_WDR78	WDR78	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"In NSCLC, circ_0006677 is down-regulated and acts as a tumor suppressor. It sponges miR-1245a to increase SATB2 expression and thereby inhibits malignant phenotypes (proliferation, migration, invasion, stemness) while promoting apoptosis, partly via inhibiting MEK/ERK signaling."	0.8254
35083866	Thoracic cancer	2022	circFIG 4 drives the carcinogenesis and metastasis of esophagus cancer via the miR-493-5p/E2F3 axis.	hsa_circ_0077607		hsa_circ_FIG4	FIG 4	Esophageal cancer / EC	MONDO:0007576	esophageal cancer	up-regulated	RT-qPCR	"circFIG 4 is up-regulated in esophageal cancer and promotes malignant phenotypes (proliferation, migration/invasion) while inhibiting apoptosis. Mechanistically, it functions as a ceRNA by sponging miR-493-5p to increase E2F3 expression, and circFIG 4 knockdown suppresses xenograft tumor growth."	0.8173
35085777	"Genomics, proteomics & bioinformatics"	2023	Screening Linear and Circular RNA Transcripts from Stress Granules.		circSLTM	hsa_circ_SLTM	SLTM	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	unknown	RNA-seq	"circSLTM is validated to localize in cytoplasmic stress granules in SMMC-7721 cells by RNA FISH combined with immunofluorescence. The study links SG-enriched circRNAs to stress granule formation via binding of SG-related RBPs, but does not report circSLTM expression changes or clinical relevance in HCC."	0.3213
35085777	"Genomics, proteomics & bioinformatics"	2023	Screening Linear and Circular RNA Transcripts from Stress Granules.		circARHGAP5	hsa_circ_ARHGAP5	ARHGAP5	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	unknown	RNA-seq	circARHGAP5 is experimentally validated to localize in cytoplasmic stress granules in SMMC-7721 cells by RNA FISH and immunofluorescence. The work supports an SG-related circRNA/RBP association but does not provide circARHGAP5 expression direction in HCC or prognostic/clinical associations.	0.3213
35085777	"Genomics, proteomics & bioinformatics"	2023	Screening Linear and Circular RNA Transcripts from Stress Granules.		circEXOC6B	hsa_circ_EXOC6B	EXOC6B	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RNA-seq	"circEXOC6B is reported as an SG-enriched circRNA that is significantly down-regulated in HCC tissues compared with adjacent tissues based on expression data analysis. No downstream mechanism, interacting partners, or clinical prognostic value is established in this study."	0.1768
35085777	"Genomics, proteomics & bioinformatics"	2023	Screening Linear and Circular RNA Transcripts from Stress Granules.		circCALD1	hsa_circ_CALD1	CALD1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RNA-seq	"circCALD1 is identified among SG-enriched circRNAs and is significantly down-regulated in HCC tissues versus adjacent tissues based on expression analysis. The article does not provide a validated mechanism, localization test for this circRNA, or prognosis/diagnosis evaluation."	0.1768
35085777	"Genomics, proteomics & bioinformatics"	2023	Screening Linear and Circular RNA Transcripts from Stress Granules.		circVAMP3	hsa_circ_VAMP3	VAMP3	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RNA-seq	"circVAMP3 is an SG-enriched circRNA reported to be significantly down-regulated in HCC tissues relative to adjacent tissues. The study does not validate its localization, mechanism, or clinical prognostic significance."	0.1768
35087744	Frontiers in oncology	2021	Hsa_circ_0060927 Is a Novel Tumor Biomarker by Sponging miR-195-5p in the Malignant Transformation of OLK to OSCC.	hsa_circ_0060927	circ_0060927	hsa_circ_CYP24A1	CYP24A1	oral leukoplakia / OLK	MONDO:0004844	oral mucosa leukoplakia	up-regulated	RT-qPCR; ISH; RNA-seq	"hsa_circ_0060927 is upregulated across NOM¡úOLK¡úOSCC and promotes malignant transformation-related phenotypes. It localizes mainly in the cytoplasm and functions as a ceRNA by binding miR-195-5p (via AGO2/RISC), thereby relieving miR-195-5p suppression of TRIM14 and enhancing proliferation and migration while inhibiting apoptosis in LEUK1 cells; it also shows diagnostic potential by ROC analysis."	0.8748
35091535	Cell death & disease	2022	Tumor-associated macrophages promote cholangiocarcinoma progression via exosomal Circ_0020256.	hsa_circ_0020256	Circ_0020256			cholangiocarcinoma / CCA	MONDO:0019087	cholangiocarcinoma	up-regulated	RT-qPCR; ISH; Microarray	"hsa_Circ_0020256 is up-regulated in TAM-secreted exosomes and in CCA tumor tissues, and it promotes CCA cell proliferation, migration, invasion, and xenograft growth. Mechanistically, it functions as a ceRNA by sponging miR-432-5p to increase E2F3 expression (Circ_0020256/miR-432-5p/E2F3 axis). High Circ_0020256 expression is associated with shorter overall survival and recurrence time in CCA patients."	0.8071
35093109	Journal of orthopaedic surgery and research	2022	"Circ_0001947 promotes cell proliferation, invasion, migration and inflammation and inhibits apoptosis in human rheumatoid arthritis fibroblast-like synoviocytes through miR-671-5p/STAT3 axis."	hsa_circ_0001947		hsa_circ_AFF2	AFF2	rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"circ_0001947 (circAFF2) is up-regulated in RA synovial tissues and RA-FLSs, mainly localizes to the cytoplasm, and promotes RA-FLS proliferation, invasion, migration and inflammatory cytokine production while inhibiting apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-671-5p to increase STAT3 expression (circ_0001947/miR-671-5p/STAT3 axis)."	0.7229
35095932	Frontiers in immunology	2021	Circulating Exosomal circRNAs Contribute to Potential Diagnostic Value of Large Artery Atherosclerotic Stroke.	hsa_circ_0043837	circ_0043837			large artery atherosclerotic stroke / LAA stroke	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR; RNA-seq	"Exosomal circ_0043837 is down-regulated in LAA stroke and serves as an independent predictive factor with strong diagnostic performance (especially when combined with circ_0001801). Its lower level correlates with higher NIHSS scores, and it is also an independent risk factor used to predict plaque rupture in atherosclerosis-related settings."	0.6023
35095932	Frontiers in immunology	2021	Circulating Exosomal circRNAs Contribute to Potential Diagnostic Value of Large Artery Atherosclerotic Stroke.	hsa_circ_0001801	circ_0001801			large artery atherosclerotic stroke / LAA stroke	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR; RNA-seq	"Exosomal circ_0001801 is down-regulated in LAA stroke, acts as an independent diagnostic biomarker (especially combined with circ_0043837), and its decreased expression correlates with worse stroke severity (higher NIHSS). It also functions as an independent risk factor used in models/nomogram to predict plaque rupture risk in the atherosclerotic setting; plasma circ_0001801 remains associated with LAA but performs worse than exosomal measurement."	0.6023
35095932	Frontiers in immunology	2021	Circulating Exosomal circRNAs Contribute to Potential Diagnostic Value of Large Artery Atherosclerotic Stroke.		novel_circ_0010155	hsa_circ_ZNF91	ZNF91	large artery atherosclerotic stroke / LAA stroke	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR; RNA-seq	"Novel_circ_0010155 (derived from ZNF91) is down-regulated in circulating exosomes from LAA stroke patients versus controls and was selected for RT-qPCR validation based on immune/inflammatory enrichment. In large replication it did not distinguish LAA from SAO, suggesting limited specificity for LAA subtype among stroke groups."	0.4685
35095932	Frontiers in immunology	2021	Circulating Exosomal circRNAs Contribute to Potential Diagnostic Value of Large Artery Atherosclerotic Stroke.	hsa_circ_0005627	circ_0005627			large artery atherosclerotic stroke / LAA stroke	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; RNA-seq	"Circ_0005627 is up-regulated in circulating exosomes of LAA stroke versus controls and was selected for validation based on immune/inflammatory enrichment. In large replication it did not distinguish LAA from SAO, limiting its specificity for LAA subtype; functional prediction links it to RNA modification."	0.4685
35095932	Frontiers in immunology	2021	Circulating Exosomal circRNAs Contribute to Potential Diagnostic Value of Large Artery Atherosclerotic Stroke.	hsa_circ_0005585	circ_0005585			large artery atherosclerotic stroke / LAA stroke	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR; RNA-seq	"Circ_0005585 is down-regulated in circulating exosomes from LAA stroke patients versus controls and shows differential expression between LAA and SAO in the large replication stage. The study links it (by functional enrichment/prediction) to mitochondrial function, but does not define a specific molecular regulatory axis."	0.4685
35096013	Frontiers in genetics	2021	Comprehensive Assessment of Serum hsa_circ_0070354 as a Novel Diagnostic and Predictive Biomarker in Non-small Cell Lung Cancer.	hsa_circ_0070354	circRNA 0070354	hsa_circ_PTPN13	PTPN13	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0070354 is up-regulated in NSCLC tissues, cell lines, and patient serum, and mainly localizes to the cytoplasm. It serves as a serum biomarker with moderate diagnostic performance (AUC 0.660) and high expression predicts poor overall survival, acting as an independent prognostic factor; its ceRNA network and MAPK/ErbB-related pathways were bioinformatically predicted but not experimentally confirmed."	0.7378
35096421	Journal of ophthalmology	2022	Circ-ADAM9 Promotes High Glucose-Induced Retinal Pigment Epithelial Cell Injury in DR via Regulating miR-338-3p/CARM1 Axis.	hsa_circ_0084043		hsa_circ_ADAM9	ADAM9	diabetic retinopathy / DR	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR	"circ-ADAM9 is upregulated in DR patient serum and in high glucose-treated ARPE-19 cells. Functionally, circ-ADAM9 promotes HG-induced RPE cell injury (inflammation, apoptosis, oxidative stress) and suppresses proliferation. Mechanistically, it sponges miR-338-3p to increase CARM1 expression (circ-ADAM9/miR-338-3p/CARM1 axis)."	0.7795
35097124	BioMed research international	2022	The Function of circRNA-0047604 in Regulating the Tumor Suppressor Gene DACH1 in Breast Cancer.	hsa_circ_0047604	circRNA-0047604	hsa_circ_SMAD2	SMAD2	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	"This study reports that hsa_circ_0047604/circ_0047604 (derived from SMAD2) is down-regulated in breast cancer tissues. Functionally, it suppresses breast cancer cell proliferation and migration by sponging miR-548o, thereby increasing the tumor suppressor DACH1 expression (circ_0047604_miR-548o_DACH1 ceRNA axis)."	0.6521
35098570	Journal of clinical laboratory analysis	2022	Potential roles of hsa_circ_000839 and hsa_circ_0005986 in breast cancer.	hsa_circ_0005986		hsa_circ_PRDM2	PRDM2	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	"hsa_circ_0005986 is significantly down-regulated in breast cancer tumor tissues versus paired adjacent normal tissues, suggesting a tumor-suppressive role. The study further constructed an in silico ceRNA network for hsa_circ_0005986, implicating multiple predicted miRNAs and mRNAs (e.g., hsa-mir-326/hsa-mir-421 and GLI1/SMAD4/SP1/FOXO4) in BC-related regulatory relationships."	0.348
35098570	Journal of clinical laboratory analysis	2022	Potential roles of hsa_circ_000839 and hsa_circ_0005986 in breast cancer.	hsa_circ_0000497	hsa_circ_000839	hsa_circ_SLAIN	SLAIN	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	"hsa_circ_000839 is significantly down-regulated in breast cancer tumor tissues compared with paired adjacent tissues, supporting a tumor-suppressive association in BC. The study computationally constructed a hsa_circ_000839-centered ceRNA network (circRNA-miRNA-mRNA), highlighting predicted interactions with multiple miRNAs (e.g., hsa-mir-409-3p, hsa-mir-590-5p) and cancer-relevant mRNAs (e.g., RECK, ZEB1, BTG2)."	0.348
35099348	Drug delivery	2022	Mesenchymal stem cell-originated exosomal circDIDO1 suppresses hepatic stellate cell activation by miR-141-3p/PTEN/AKT pathway in human liver fibrosis.	hsa_circ_0061137	circDIDO1	hsa_circ_DIDO1	DIDO1	liver fibrosis	MONDO:0005155	cirrhosis of liver	down-regulated	RT-qPCR	"circDIDO1 is a DIDO1-derived cytoplasmic circRNA that is delivered via MSC exosomes to hepatic stellate cells, where it sponges miR-141-3p to increase PTEN and inhibit AKT activation, thereby suppressing HSC activation and fibrotic phenotypes. Serum exosomal circDIDO1 is reduced in liver failure patients and shows diagnostic value for liver fibrosis in this context."	0.8735
35100076	Bioengineered	2022	Circular RNA 0000654 facilitates the growth of gastric cancer cells through absorbing microRNA-149-5p to up-regulate inhibin-beta A.	hsa_circ_0000654	circRNA 0000654	hsa_circ_CHD2	CHD2	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_0000654 is up-regulated in gastric cancer and promotes malignant phenotypes and xenograft growth. Mechanistically, it functions as a miR-149-5p sponge to relieve repression of INHBA, thereby enhancing GC progression."	0.8005
35101080	Journal of translational medicine	2022	Circular RNA circCSPP1 promotes the occurrence and development of colon cancer by sponging miR-431 and regulating ROCK1 and ZEB1.	hsa_circ_0001806	circCSPP1	hsa_circ_CSPP1	CSPP1	colon cancer	MONDO:0021063	malignant colon neoplasm	up-regulated	RT-qPCR	"circCSPP1 (hsa_circ_0001806), derived from CSPP1 exons 8_11, is upregulated in colon cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes colon cancer proliferation, migration, invasion, tumor growth and metastasis by sponging miR-431, thereby upregulating ROCK1 and ZEB1 and influencing cell-cycle and EMT-related proteins."	0.8164
35103245	Journal of immunology research	2022	Insights from Dysregulated mRNA Expression Profile of beta-Cells in Response to Proinflammatory Cytokines.		circRNA 006029			type 1 diabetes mellitus / T1DM	MONDO:0005147	type 1 diabetes mellitus	up-regulated	Microarray	"In cytokine-treated MIN6 beta-cells (a T1DM-relevant inflammatory context), circRNA 006029 was upregulated and showed strong coexpression associations with many dysregulated mRNAs in the circRNA_mRNA network, suggesting it may participate in regulating mRNA programs linked to beta-cell dysfunction."	0.1768
35103245	Journal of immunology research	2022	Insights from Dysregulated mRNA Expression Profile of beta-Cells in Response to Proinflammatory Cytokines.		circRNA 000286			type 1 diabetes mellitus / T1DM	MONDO:0005147	type 1 diabetes mellitus	down-regulated	Microarray	"CircRNA 000286 was downregulated in cytokine-stimulated MIN6 beta-cells and has been clarified by the authors' prior work to regulate insulin biosynthesis and beta-cell apoptosis; in this study it also showed broad coexpression associations with dysregulated mRNAs, suggesting involvement in mRNA regulatory programs relevant to T1DM-related beta-cell injury."	0.1768
35103245	Journal of immunology research	2022	Insights from Dysregulated mRNA Expression Profile of beta-Cells in Response to Proinflammatory Cytokines.		circRNA 017277			type 1 diabetes mellitus / T1DM	MONDO:0005147	type 1 diabetes mellitus	down-regulated	Microarray	"CircRNA 017277 was downregulated in cytokine-stimulated MIN6 beta-cells and (per the authors' prior work) regulates insulin biosynthesis and beta-cell apoptosis; in this study it also broadly coexpressed with many dysregulated mRNAs, implicating it in inflammatory beta-cell dysfunction relevant to T1DM."	0.1768
35103245	Journal of immunology research	2022	Insights from Dysregulated mRNA Expression Profile of beta-Cells in Response to Proinflammatory Cytokines.		circRNA 013053			type 1 diabetes mellitus / T1DM	MONDO:0005147	type 1 diabetes mellitus	up-regulated	Microarray	"CircRNA 013053 was upregulated in cytokine-treated MIN6 beta-cells and, within the circRNA_mRNA coexpression network, was specifically associated with the mRNA Slc7a2, implying a more targeted potential regulatory relationship in this inflammatory beta-cell damage model relevant to T1DM."	0.1768
35106926	Thoracic cancer	2022	Knockdown of circ-RAD23B inhibits non-small cell lung cancer progression via the miR-142-3p/MAP4K3 axis.	hsa_circ_0087862	Circ_RAD23B	hsa_circ_RAD23B	RAD23B	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ-RAD23B is up-regulated in NSCLC and functions as an oncogenic circRNA. Its knockdown suppresses malignant phenotypes and tumor growth by sponging miR-142-3p to relieve repression of MAP4K3, with downstream reduction of MAPK pathway activation (p-ERK1/2, p-JNK, p-p38). High circ-RAD23B expression correlates with poorer patient survival."	0.7133
35110626	Scientific reports	2022	Expression ratio of circular to linear ANRIL in hypertensive patients with coronary artery disease.		circular ANRIL	hsa_circ_ANRIL	ANRIL	coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	down-regulated	RT-qPCR	"Circular ANRIL is down-regulated in blood from hypertensive patients with CAD compared with hypertensive controls without CAD, suggesting an atheroprotective association. The study proposes that reduced circular ANRIL (and reduced circular/linear ANRIL ratio) may have diagnostic value for CAD, but does not establish a specific molecular mechanism."	0.2995
35112991	Bioengineered	2022	Circular RNA circ_0000518 promotes breast cancer progression through the microRNA-1225-3p/SRY-box transcription factor 4 pathway.	hsa_circ_0000518	circ_0000518			breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circ_0000518 is up-regulated in breast cancer tissues and cell lines and promotes proliferation, migration, and invasion in vitro. It acts as a ceRNA by sponging miR-1225-3p, thereby relieving repression of SOX4 and enhancing SOX4 expression."	0.697
35114890	Bioengineered	2022	Circular RNA circ_UBAP2 facilitates the progression of osteosarcoma by regulating microRNA miR-637/high-mobility group box (HMGB) 2 axis.		circUBAP2	hsa_circ_UBAP2	UBAP2	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ_UBAP2 is up-regulated in osteosarcoma tissues and cell lines and promotes malignant behaviors (proliferation, migration, invasion) while inhibiting apoptosis. It mainly localizes to the cytoplasm and acts as a ceRNA that sponges miR-637 to relieve repression of HMGB2, thereby promoting osteosarcoma progression in vitro and in xenograft models."	0.7795
35114891	Bioengineered	2022	Upregulation of exosomal circPLK1 promotes the development of non-small cell lung cancer through the miR-1294/ high mobility group protein A1 axis.		circPLK1	hsa_circ_PLK1	PLK1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circPLK1 is upregulated in NSCLC tissues and serum exosomes and promotes NSCLC cell proliferation, migration, and invasion while inhibiting apoptosis. Mechanistically, exosomal circPLK1 functions as a miR-1294 sponge to maintain high HMGA1 expression, forming a circPLK1/miR-1294/HMGA1 regulatory axis. High circPLK1 expression is associated with poor overall survival and shows potential diagnostic value in NSCLC."	0.7972
35116004	Frontiers in endocrinology	2021	hsa_circ_0111707 Is Associated With Risk of Stress-Related Type 2 Diabetes via Sponging miR-144-3p.	hsa_circ_0111707				type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RT-qPCR	"hsa_circ_0111707 is down-regulated in PBMCs of T2D and IFG cases and lower expression predicts higher T2D risk. Mechanistically, it binds and sponges miR-144-3p (ceRNA), with a reported positive correlation to NR3C1 expression, supporting a hsa_circ_0111707/miR-144-3p/NR3C1 regulatory relationship in stress-related T2D."	0.6944
35116078	Cardiovascular therapeutics	2022	hsa_circWDR37_016 Regulates Hypoxia-Induced Proliferation of Pulmonary Arterial Smooth Muscle Cells.			hsa_circ_WDR37	WDR37	pulmonary arterial hypertension / PAH	MONDO:0015924	pulmonary arterial hypertension	up-regulated	RT-qPCR	"In PAH/hypoxia-exposed human PASMCs, circWDR37 (hsa_circWDR37_016) is up-regulated and promotes proliferation, cell-cycle progression, migration, and resistance to apoptosis. Mechanistically, it acts as a miRNA sponge by directly binding hsa-miR-138-5p, supporting a circWDR37/miR-138 regulatory module implicated in immunoregulatory/inflammatory processes."	0.6435
35116238	Translational cancer research	2021	"Identification of a novel circRNA, hsa_circ_0065898, that regulates tumor growth in cervical squamous cell carcinoma."	hsa_circ_0065898		hsa_circ_DCAF1	DCAF1	cervical squamous cell carcinoma / CSCC	MONDO:0006143	cervical squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0065898 (circDCAF1) is up-regulated in CSCC and promotes SiHa cell proliferation, migration, and invasion. The study constructed a predicted circRNA_miRNA_mRNA network (miRNAs from circBase; targets predicted) and enrichment implicated Hippo and p53 signaling pathways."	0.4852
35116241	Translational cancer research	2021	Transcriptome Sequencing reveals the expressed profiles of mRNA and ncRNAs and regulate network via ceRNA mediated molecular mechanism of lung adenocarcinoma bone metastasis in Xuanwei.	hsa_circ_0000053				lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	This study reports that hsa_circ_0000053 is up-regulated in Xuanwei lung adenocarcinoma bone metastasis and may function as a ceRNA. It is proposed to sponge miR-196a-5p/miR-196b-5p and thereby affect HOXA5 within a circRNA/miRNA/mRNA regulatory network relevant to bone metastasis.	0.5466
35116241	Translational cancer research	2021	Transcriptome Sequencing reveals the expressed profiles of mRNA and ncRNAs and regulate network via ceRNA mediated molecular mechanism of lung adenocarcinoma bone metastasis in Xuanwei.		circ_00001495			lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circ_00001495 is identified as a differentially expressed circRNA and is validated as up-regulated in Xuanwei lung adenocarcinoma bone metastasis (serum) by RT-qPCR, consistent with sequencing results. The study does not provide a specific downstream miRNA/mRNA axis for this circRNA."	0.5466
35116769	Translational cancer research	2019	Circular RNA hsa_circ_0002124 promotes hepatocellular carcinoma cell proliferation through the MAPK pathway.	hsa_circ_0002124		hsa_circ_NuSAP1	NuSAP1 / NUSAP1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"hsa_circ_0002124 is up-regulated in HCC tissues and several HCC cell lines. Functional assays in 97H cells show that it promotes proliferation, migration and invasion, facilitates cell-cycle progression, and inhibits apoptosis. Mechanistically, it is proposed to act as a miRNA sponge and enhance MAPK pathway activity (p-JNK/JNK, p-ERK/ERK, p-P38/P38, c-Myc), suggesting biomarker potential for HCC."	0.7045
35116915	Translational cancer research	2019	"Circular RNA SMARCA5 is overexpressed and promotes cell proliferation, migration as well as invasion while inhibits cell apoptosis in bladder cancer."	hsa_circ_0001445		hsa_circ_SMARCA5	SMARCA5	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circ-SMARCA5 (hsa_circ_0001445) is up-regulated in bladder cancer tissues and several bladder cancer cell lines. Gain- and loss-of-function experiments in UM-UC-3 cells show it promotes proliferation, migration and invasion while inhibiting apoptosis, and it positively affects SMARCA5 expression."	0.6825
35117016	Translational cancer research	2019	STAT3 activation regulated circ-STAT3.46 promote expression of IGF1R by sponging of miR-139-5p in human colon cancer.	hsa_circ_0043817	circ-STAT3.46	hsa_circ_STAT3	STAT3	colon cancer	MONDO:0021063	malignant colon neoplasm	up-regulated	RT-qPCR	"In human colon cancer, circ-STAT3.46 is up-regulated in tumor tissue and serum exosomes and correlates with advanced TNM stage and poorer post-surgery survival. Mechanistically, IGF1/IGF1R/STAT3 signaling induces circ-STAT3.46, which sponges miR-139-5p to de-repress IGF1R expression, supporting STAT3-associated tumor progression."	0.7512
35117027	Translational cancer research	2019	Down-regulated hsa_circ_0067934 facilitated the progression of gastric cancer by sponging hsa-mir-4705 to downgrade the expression of BMPR1B.	hsa_circ_0007991		hsa_circ_EIF4G3	EIF4G3	gastric cancer / GC	MONDO:0001056	gastric cancer	dysregulated	Microarray	"hsa_circ_0007991 was identified as a differentially expressed circRNA in gastric cancer by integrated analysis of GEO circRNA microarrays. The study suggests it may relate to cancer-associated pathways (e.g., pluripotency of stem cells and p53 signaling) based on enrichment of predicted downstream genes, but no specific validated miRNA/mRNA axis was supported by TCGA intersection for this circRNA."	0.1768
35117027	Translational cancer research	2019	Down-regulated hsa_circ_0067934 facilitated the progression of gastric cancer by sponging hsa-mir-4705 to downgrade the expression of BMPR1B.	hsa_circ_0067934		hsa_circ_PRKCI	PRKCI	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	Microarray	"hsa_circ_0067934 was identified as down-regulated in gastric cancer from integrated GEO microarray datasets. The study proposes a ceRNA axis where hsa_circ_0067934 sponges hsa-mir-4705 to regulate BMPR1B, potentially impacting Hippo signaling and stem-cell pluripotency-related pathways, with suggested biomarker/therapeutic relevance, but without experimental wet-lab validation."	0.2465
35117180	Translational cancer research	2020	Circular RNA expression pattern in cisplatin-resistant osteosarcoma cells.	hsa_circ_0008336		hsa_circ_BBS9	BBS9	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0008336 is up-regulated in cisplatin-resistant osteosarcoma cell lines (U2OS-R and MG63-R) compared with their parental cells, suggesting a potential association with cisplatin resistance. No specific downstream mechanism was experimentally defined in this study."	0.3401
35117180	Translational cancer research	2020	Circular RNA expression pattern in cisplatin-resistant osteosarcoma cells.	hsa_circ_0004664				osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0004664 is significantly up-regulated in cisplatin-resistant osteosarcoma cell lines (U2OS-R and MG63-R) versus parental cells. The study did not experimentally define its downstream targets or mechanism.	0.3401
35117180	Translational cancer research	2020	Circular RNA expression pattern in cisplatin-resistant osteosarcoma cells.	hsa_circ_0003302				osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0003302 is up-regulated in cisplatin-resistant osteosarcoma cell lines (U2OS-R and MG63-R). The study suggests a potential link to cisplatin resistance but does not define a specific molecular mechanism.	0.3401
35117180	Translational cancer research	2020	Circular RNA expression pattern in cisplatin-resistant osteosarcoma cells.	hsa_circ_0002809		hsa_circ_TRIM37	TRIM37	osteosarcoma / OS	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0002809 is down-regulated in cisplatin-resistant U2OS-R cells versus U2OS, and shows a non-significant decreased trend in MG63-R versus MG63. The study did not provide a defined mechanism or function for this circRNA in cisplatin resistance."	0.3401
35117187	Translational cancer research	2020	Potential of circular RNA itchy E3 ubiquitin protein ligase as a biomarker and treatment target for multiple myeloma.		circular RNA itchy E3 ubiquitin protein ligase	hsa_circ_ITCH	ITCH	multiple myeloma / MM	MONDO:0009693	plasma cell myeloma	down-regulated	RT-qPCR	"circ-ITCH is down-regulated in multiple myeloma bone marrow samples and in several MM cell lines. Higher circ-ITCH expression is associated with lower ISS stage and longer PFS/OS, and circ-ITCH overexpression suppresses proliferation while promoting apoptosis in U226 cells, suggesting a tumor-suppressive role and potential biomarker/therapeutic value in MM."	0.6419
35117697	Translational cancer research	2020	Circular RNA circZFR promotes tumorigenic capacity of lung cancer via CCND1.	hsa_circ_0072088	circZFR	hsa_circ_ZFR	ZFR	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; Northern Blot; ISH	"circZFR is up-regulated in lung cancer tissues and mainly localized in the nucleus. Functional assays show that circZFR promotes lung cancer cell growth, colony formation, and xenograft tumor propagation, at least partly by enhancing CCND1 transcription and activating cell-cycle signaling."	0.8087
35120571	Arthritis research & therapy	2022	N6-methyladenosine-dependent modification of circGARS acts as a new player that promotes SLE progression through the NF-kappaB/A20 axis.	hsa_circ_0009000	circGARS	hsa_circ_GARS	GARS	systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	up-regulated	RT-qPCR; RNA-seq	"CircGARS (hsa_circ_0009000), derived from GARS, is upregulated in SLE PBMCs and correlates with disease activity, showing diagnostic potential. Mechanistically, it sponges miR-19a (notably miR-19a-5p) to modulate YTHDF2 and A20 (TNFAIP3), thereby promoting NF-kappaB_mediated immune/inflammatory responses; it also interacts with m6A-associated proteins such as HNRNPC, suggesting m6A-dependent regulation."	0.8587
35123506	Journal of translational medicine	2022	Clinical utility of cerebrospinal fluid-derived circular RNAs in lung adenocarcinoma patients with brain metastases.	hsa_circ_0003011		hsa_circ_RFWD2	RFWD2	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	unknown	RT-qPCR; RNA-seq	"hsa_circ_0003011 was selected from CSF circRNAs associated with WNT signaling. In A549 cells, shRNA-mediated knockdown reduced proliferation and invasion, suggesting a pro-tumor role in lung adenocarcinoma with brain metastases."	0.7325
35123506	Journal of translational medicine	2022	Clinical utility of cerebrospinal fluid-derived circular RNAs in lung adenocarcinoma patients with brain metastases.	hsa_circ_0008604	circ_0008604	hsa_circ_RHOT1	RHOT1	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	unknown	RT-qPCR; RNA-seq	"hsa_circ_0008604 (RHOT1-derived) was a WNT-pathway-associated CSF circRNA and was detected only in CSF from lung cancer BM patients in an independent validation set. Knockdown experiments in A549 implied it supports proliferation/invasion, and network analysis linked it to WNT signaling targets (Wnt-3/5a)."	0.7718
35123506	Journal of translational medicine	2022	Clinical utility of cerebrospinal fluid-derived circular RNAs in lung adenocarcinoma patients with brain metastases.	hsa_circ_0002360	circ_0002360	hsa_circ_RUNX1	RUNX1	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	unknown	RT-qPCR; RNA-seq	"hsa_circ_0002360 (RUNX1-derived) is a CSF circRNA candidate associated with WNT signaling. It was detected only in CSF from BM lung adenocarcinoma patients in a validation cohort and is suggested to promote proliferation, migration, and invasion, potentially via a ceRNA network involving WNT pathway genes."	0.7718
35123506	Journal of translational medicine	2022	Clinical utility of cerebrospinal fluid-derived circular RNAs in lung adenocarcinoma patients with brain metastases.	hsa_circ_0009117	circ_0009117	hsa_circ_RERE	RERE	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	unknown	RT-qPCR; RNA-seq	"hsa_circ_0009117 (RERE-derived) was selected as a WNT-associated CSF circRNA candidate and showed pro-proliferative/invasive effects in A549 upon knockdown, but it was not detected in CSF in an independent RT-PCR validation cohort, lowering overall evidence for its clinical detectability."	0.6046
35123506	Journal of translational medicine	2022	Clinical utility of cerebrospinal fluid-derived circular RNAs in lung adenocarcinoma patients with brain metastases.	hsa_circ_0002588	circ_0002588	hsa_circ_RBMS2	RBMS2	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	unknown	RT-qPCR; RNA-seq	"hsa_circ_0002588 (RBMS2-derived) is a WNT-associated CSF circRNA candidate detected only in CSF from BM lung adenocarcinoma patients in a validation set. Knockdown in HCC827 reduced cell proliferation, and bioinformatic analyses linked it to cancer pathways including MYC-associated signaling."	0.7474
35123588	Biomaterials research	2022	Treatment of bladder cancer by geoinspired synthetic chrysotile nanocarrier-delivered circPRMT5 siRNA.		circPRMT5	hsa_circ_PRMT5	PRMT5	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circPRMT5 acts as an oncogenic circRNA in bladder cancer. Nanotube-delivered si-circPRMT5 silences circPRMT5, modulates the miR-30c/SNAIL1/E-cadherin axis, suppresses proliferation/migration/invasion and metastasis, and increases apoptosis in vitro and in multiple in vivo bladder cancer models."	0.5762
35125403	Journal of the Chinese Medical Association : JCMA	2022	Identification of plasma hsa_circ_0000190 and 0001649 as biomarkers for predicting the recurrence and treatment response of patients with oral squamous cell carcinoma.	hsa_circ_0000190		hsa_circ_CNIH4	CNIH4	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR	"hsa_circ_0000190 is decreased in OSCC patient plasma, especially in late-stage disease, and shows diagnostic utility. Higher/ascending plasma levels may indicate a better response to induction chemotherapy and lower levels may associate with second primary OSCC risk."	0.7322
35125403	Journal of the Chinese Medical Association : JCMA	2022	Identification of plasma hsa_circ_0000190 and 0001649 as biomarkers for predicting the recurrence and treatment response of patients with oral squamous cell carcinoma.	hsa_circ_0001649		hsa_circ_SHPRH	SHPRH	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR	"hsa_circ_0001649 is decreased in OSCC patient plasma and low levels are associated with recurrence, shorter recurrence interval, and poorer survival outcomes, supporting its use as a prognostic plasma biomarker."	0.6656
35126807	Oxidative medicine and cellular longevity	2022	Cardioprotective Effect of circ_SMG6 Knockdown against Myocardial Ischemia/Reperfusion Injury Correlates with miR-138-5p-Mediated EGR1/TLR4/TRIF Inactivation.	hsa_circ_0041387	circ_SMG6	hsa_circ_SMG6	SMG6	myocardial ischemia/reperfusion injury	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR; RNA-seq	"circ_SMG6 is upregulated in myocardial I/R injury and aggravates cardiac damage by sponging miR-138-5p, thereby increasing EGR1 expression and activating TLR4/TRIF signaling. Silencing circ_SMG6 increases miR-138-5p, reduces EGR1, limits neutrophil recruitment, and alleviates myocardial injury and cardiomyocyte apoptosis."	0.6966
35126807	Oxidative medicine and cellular longevity	2022	Cardioprotective Effect of circ_SMG6 Knockdown against Myocardial Ischemia/Reperfusion Injury Correlates with miR-138-5p-Mediated EGR1/TLR4/TRIF Inactivation.	mmu_circ_0000288	circ_SMG6	mmu_circ_SMG6	SMG6	myocardial ischemia/reperfusion injury	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR; RNA-seq	"circ_SMG6 is upregulated in myocardial I/R injury and aggravates cardiac damage by sponging miR-138-5p, thereby increasing EGR1 expression and activating TLR4/TRIF signaling. Silencing circ_SMG6 increases miR-138-5p, reduces EGR1, limits neutrophil recruitment, and alleviates myocardial injury and cardiomyocyte apoptosis."	0.6966
35127342	Analytical cellular pathology (Amsterdam)	2022	circ_ZFR Is Linked to Paclitaxel Resistance in Cervical Cancer via miR-944 Sponging and IL-10 Upregulation.	hsa_circ_0072088	circ_ZFR	hsa_circ_ZFR	ZFR	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ_ZFR is up-regulated in paclitaxel-resistant cervical cancer tissues and cell models and promotes PTX resistance. Mechanistically, it sponges miR-944 to increase IL-10 expression, thereby reducing PTX sensitivity."	0.7715
35127703	Frontiers in cell and developmental biology	2021	Therapeutic Potential of Exosomes Derived From circRNA_0002113 Lacking Mesenchymal Stem Cells in Myocardial Infarction.	rno_circ_0002113		rno_circ_IFNGR2	IFNGR2	myocardial infarction / MI	MONDO:0005068	myocardial infarction	up-regulated	RT-qPCR; Northern Blot	"circRNA_0002113 is up-regulated in the A/R cardiomyocyte model and promotes apoptosis/myocardial injury. Therapeutically, MSC-derived exosomes with circRNA_0002113 knockdown alleviate myocardial I/R injury by sponging miR-188-3p, reducing RUNX1 nuclear translocation and affecting the USP7/p53 apoptosis-related pathway."	0.6737
35129424	Bioengineered	2022	Identification of circular RNAs and functional competing endogenous RNA networks in human proximal tubular epithelial cells treated with sodium-glucose cotransporter 2 inhibitor dapagliflozin in diabetic kidney disease.		hsa_circ_012448	hsa_circ_EPS15	EPS15	diabetic kidney disease / DKD	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR; Microarray	"In high-glucose_treated HK-2 cells (an in vitro DKD model), hsa_circRNA_012448 is up-regulated and is reduced by dapagliflozin. It functions in a ceRNA-like axis with hsa-miR-29b-2-5p and GSK3beta, promoting oxidative stress (ROS generation), suggesting a mechanism for dapagliflozin¡¯s protective action in DKD."	0.5695
35129424	Bioengineered	2022	Identification of circular RNAs and functional competing endogenous RNA networks in human proximal tubular epithelial cells treated with sodium-glucose cotransporter 2 inhibitor dapagliflozin in diabetic kidney disease.		hsa_circRNA_001586	hsa_circ_HIST1H3D	HIST1H3D	diabetic kidney disease / DKD	MONDO:0005016	diabetic kidney disease	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_001586 is down-regulated by high glucose and restored by dapagliflozin in HK-2 cells. The study constructed and analyzed a predicted hsa_circRNA_001586-centered ceRNA network (hub miRNAs include hsa-miR-4739, hsa-miR-7851-3p, and hsa-miR-1273 g-3p) that may contribute to dapagliflozin¡¯s protective effects in DKD, but direct functional validation for this circRNA was not shown."	0.3858
35130798	Bioengineered	2022	Hsa_circ_0039569 facilitates the progression of endometrial carcinoma by targeting the miR-197/high mobility group protein A1 axis.	hsa_circ_0039569		hsa_circ_CCL22	CCL22	endometrial carcinoma	MONDO:0002447	endometrial carcinoma	up-regulated	RT-qPCR	"hsa_circ_0039569 is up-regulated in endometrial carcinoma tissues and cell lines and predominantly localizes to the cytoplasm. It promotes proliferation, migration, and invasion while inhibiting apoptosis by acting as a ceRNA sponge for miR-197, thereby increasing HMGA1 expression through the miR-197/HMGA1 axis."	0.73
35132928	Bioengineered	2022	CircCAMSAP1 promotes non-small cell lung cancer proliferation and inhibits cell apoptosis by sponging miR-1182 and regulating BIRC5.	hsa_circ_0001900	circCAMSAP1	hsa_circ_CAMSAP1	CAMSAP1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circCAMSAP1 is up-regulated in NSCLC tissues and cell lines and promotes tumor cell proliferation while inhibiting apoptosis. Mechanistically, it functions as a ceRNA by sponging miR-1182 to increase BIRC5 (survivin) expression, and BIRC5 rescue experiments support the circCAMSAP1/miR-1182/BIRC5 axis in NSCLC progression."	0.78
35135416	Bioengineered	2022	CircRNA ZNF609 promotes the growth and metastasis of thyroid cancer in vivo and in vitro by downregulating miR-514a-5p.	hsa_circ_0000615		hsa_circ_ZNF609	ZNF609	thyroid cancer / TC	MONDO:0002108	thyroid cancer	up-regulated	RT-qPCR	"circ-ZNF609 is up-regulated in thyroid cancer cell lines and acts as an oncogenic circRNA. It promotes proliferation, migration/invasion and xenograft tumor growth mainly by sponging miR-514a-5p, as supported by luciferase binding and rescue experiments with miR-514a-5p inhibition."	0.6544
35135542	Molecular cancer	2022	"circPTEN1, a circular RNA generated from PTEN, suppresses cancer progression through inhibition of TGF-beta/Smad signaling."	hsa_circ_0002232	circPTEN1	hsa_circ_PTEN	PTEN	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Northern Blot; ISH	"circPTEN1 (hsa_circ_0002232) is down-regulated in colorectal/colon cancer and functions as a tumor suppressor. It directly binds Smad4 (MH2 domain) to block Smad2/3-Smad4 complex formation and nuclear translocation, thereby inhibiting TGF-beta/SMAD-driven EMT and metastasis. Low circPTEN1 expression is associated with advanced metastatic features and poorer overall survival."	0.8525
35136049	Cell death discovery	2022	Hsa_circ_0134111 promotes intervertebral disc degeneration via sponging miR-578.	hsa_circ_0134111	circ_0134111			intervertebral disc degeneration / IDD	MONDO:0011385	intervertebral disk degenerative disorder	up-regulated	RT-qPCR	"circ_0134111 is up-regulated in human IDD disc tissues and its higher expression associates with greater disease severity. In NP cells, circ_0134111 promotes proliferation, inflammatory cytokine production and ECM degradation by sponging miR-578, which results in increased expression of ECM-degrading enzymes (e.g., ADAMTS-5 and MMP-9)."	0.6369
35136398	Journal of geriatric cardiology : JGC	2021	MiR-21-5p-expressing bone marrow mesenchymal stem cells alleviate myocardial ischemia/reperfusion injury by regulating the circRNA_0031672/miR-21-5p/programmed cell death protein 4 pathway.	rno_circ_0031672	circRNA_0031672	rno_circ_RALGAPA1	RALGAPA1	myocardial ischemia/reperfusion injury	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR	"circRNA_0031672 is up-regulated in rat myocardial ischemia/reperfusion injury and H/R-treated H9C2 cardiomyocytes. It promotes cardiomyocyte apoptosis and reduces viability by sponging miR-21-5p, thereby derepressing PDCD4 (circRNA_0031672/miR-21-5p/PDCD4 ceRNA axis)."	0.6908
35137664	Bioengineered	2022	Circular RNA circCHFR downregulation protects against oxidized low-density lipoprotein-induced endothelial injury via regulation of microRNA-15b-5p/growth arrest and DNA damage inducible gamma.	hsa_circ_0029589		hsa_circ_CHFR	CHFR	atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"circCHFR (circ_0029589), derived from CHFR, is up-regulated in atherosclerosis patient serum and in ox-LDL-treated HUVECs. It promotes ox-LDL-induced endothelial injury by sponging miR-15b-5p, thereby relieving repression of GADD45G and increasing apoptosis and inflammatory cytokine secretion; circCHFR knockdown is protective."	0.7032
35139763	Bioengineered	2022	Cancer-associated fibroblast exosomes promote chemoresistance to cisplatin in hepatocellular carcinoma through circZFR targeting signal transducers and activators of transcription (STAT3)/ nuclear factor -kappa B (NF-kappaB) pathway.		circZFR	hsa_circ_ZFR	ZFR	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circZFR is up-regulated in cisplatin-resistant HCC cells and in CAF-derived exosomes. CAF exosomes transfer circZFR to HCC cells, suppress STAT3/NF-kappaB phosphorylation, increase cell viability, reduce apoptosis, and thereby promote cisplatin (DDP) chemoresistance and tumor growth in vitro and in a nude-mouse xenograft model."	0.5442
35139874	Molecular cancer	2022	"Diagnostic efficacy of circular RNAs as noninvasive, liquid biopsy biomarkers for early detection of gastric cancer."	hsa_circ_0045602				gastric cancer / GC	MONDO:0001056	gastric cancer	dysregulated	RT-qPCR; Microarray	"hsa_circ_0045602 is one component of an 8-circRNA serum panel derived from GC tissue discovery and validated by RT-qPCR in tissues and serum cohorts. The panel shows diagnostic ability for GC and marker levels decrease after curative surgery, supporting a tumor-associated circulating biomarker role."	0.6556
35139874	Molecular cancer	2022	"Diagnostic efficacy of circular RNAs as noninvasive, liquid biopsy biomarkers for early detection of gastric cancer."	hsa_circ_0008768				gastric cancer / GC	MONDO:0001056	gastric cancer	dysregulated	RT-qPCR; Microarray	"hsa_circ_0008768 is included in the validated 8-circRNA serum diagnostic panel for gastric cancer developed from tissue discovery and RT-qPCR validation. The panel differentiates GC from controls and shows decreased post-surgery serum levels, indicating tumor-associated circulation signal."	0.6556
35139874	Molecular cancer	2022	"Diagnostic efficacy of circular RNAs as noninvasive, liquid biopsy biomarkers for early detection of gastric cancer."	hsa_circ_0007380				gastric cancer / GC	MONDO:0001056	gastric cancer	dysregulated	RT-qPCR; Microarray	hsa_circ_0007380 is part of the final 8-circRNA serum diagnostic panel for gastric cancer and contributes to a logistic regression risk model distinguishing GC from controls in training and validation cohorts. Post-surgery decreases for most markers support tumor specificity at the panel level.	0.6556
35139874	Molecular cancer	2022	"Diagnostic efficacy of circular RNAs as noninvasive, liquid biopsy biomarkers for early detection of gastric cancer."	hsa_circ_0002019				gastric cancer / GC	MONDO:0001056	gastric cancer	dysregulated	RT-qPCR; Microarray	"hsa_circ_0002019 is one of the 8 circRNAs in a serum-based diagnostic panel for gastric cancer identified from microarray discovery and validated by RT-qPCR. The panel shows strong diagnostic performance and decreases after surgery, supporting tumor-derived circulation signal."	0.6556
35139874	Molecular cancer	2022	"Diagnostic efficacy of circular RNAs as noninvasive, liquid biopsy biomarkers for early detection of gastric cancer."	hsa_circ_0006089				gastric cancer / GC	MONDO:0001056	gastric cancer	dysregulated	RT-qPCR; Microarray	hsa_circ_0006089 is included in the validated 8-circRNA liquid-biopsy panel for diagnosing gastric cancer. Its expression is quantified by RT-qPCR in tissue/serum cohorts and contributes to a multivariate risk model for GC detection.	0.6556
35139874	Molecular cancer	2022	"Diagnostic efficacy of circular RNAs as noninvasive, liquid biopsy biomarkers for early detection of gastric cancer."	hsa_circ_0034398				gastric cancer / GC	MONDO:0001056	gastric cancer	dysregulated	RT-qPCR; Microarray	hsa_circ_0034398 is one of the eight circRNAs measurable in serum and used to build a logistic regression risk model for gastric cancer diagnosis. It was discovered in microarray datasets and validated by RT-qPCR in tissue and serum cohorts.	0.6556
35139874	Molecular cancer	2022	"Diagnostic efficacy of circular RNAs as noninvasive, liquid biopsy biomarkers for early detection of gastric cancer."	hsa_circ_0052001				gastric cancer / GC	MONDO:0001056	gastric cancer	dysregulated	RT-qPCR; Microarray	"hsa_circ_0052001 is one of the 8 circRNAs comprising a serum-based diagnostic panel for gastric cancer identified from microarray discovery and validated by RT-qPCR. Unlike most other panel members, it was noted as an exception regarding EIF4A3 interaction in the discussion."	0.6556
35139874	Molecular cancer	2022	"Diagnostic efficacy of circular RNAs as noninvasive, liquid biopsy biomarkers for early detection of gastric cancer."	hsa_circ_0001013				gastric cancer / GC	MONDO:0001056	gastric cancer	dysregulated	RT-qPCR; Microarray	hsa_circ_0001013 is part of the final 8-circRNA serum panel for noninvasive diagnosis of gastric cancer derived from tissue discovery and validated by RT-qPCR. It contributes to the multivariable risk-prediction model used in training and validation cohorts.	0.6556
35141166	Frontiers in cellular and infection microbiology	2021	The circRNA circSIAE Inhibits Replication of Coxsackie Virus B3 by Targeting miR-331-3p and Thousand and One Amino-Acid Kinase 2.	hsa_circ_0000367	circSIAE	hsa_circ_SIAE	SIAE	CVB3 infection	MONDO:0005721	coxsackievirus infectious disease	down-regulated	RT-qPCR	"circSIAE (hsa_circ_0000367), derived from SIAE, is down-regulated upon CVB3 infection in HeLa cells. It mainly localizes to the cytoplasm and suppresses CVB3 replication by sponging miR-331-3p to relieve repression of TAOK2, which in turn dampens ERK1/2 and NF-kappaB phosphorylation and inflammatory signaling."	0.6579
35141281	Frontiers in molecular biosciences	2022	Construction and Comprehensive Analysis of a circRNA-miRNA-mRNA Regulatory Network to Reveal the Pathogenesis of Hepatocellular Carcinoma.	hsa_circ_0091581	hsa_circRNA_091581	hsa_circ_GPC3	GPC3	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_091581 is up-regulated in HCC tissues versus adjacent tissues and was selected to build a predicted circRNA_miRNA_mRNA (ceRNA) network. In the hub-gene subnetwork, it is linked to miR-661 and the hub gene CCT5."	0.6193
35141281	Frontiers in molecular biosciences	2022	Construction and Comprehensive Analysis of a circRNA-miRNA-mRNA Regulatory Network to Reveal the Pathogenesis of Hepatocellular Carcinoma.	hsa_circ_0066568	hsa_circRNA_066568	hsa_circ_ROBO1	ROBO1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circRNA_066568 is up-regulated in HCC tissues versus adjacent tissues and was selected as one of three pivotal circRNAs to construct a predicted circRNA_miRNA_mRNA network. No specific miRNA/hub-gene axes were reported for this circRNA in the final hub-gene network.	0.6193
35141281	Frontiers in molecular biosciences	2022	Construction and Comprehensive Analysis of a circRNA-miRNA-mRNA Regulatory Network to Reveal the Pathogenesis of Hepatocellular Carcinoma.	hsa_circ_0091570	hsa_circRNA_105031	hsa_circ_MBNL3	MBNL3	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_105031 is down-regulated in HCC tissues and was included to build a predicted circRNA_miRNA_mRNA (ceRNA) network. In the hub-gene subnetwork it forms multiple predicted axes with miR-1827/miR-548k/miR-671-5p/miR-595/miR-767-5p and hub genes including ESR1, YWHAZ, PRC1, DDX39B, BUB1 and LOX."	0.6193
35142578	Innate immunity	2022	Circ_0026579 alleviates LPS-induced WI-38 cells inflammation injury in infantile pneumonia.	hsa_circ_0026579	circ_0026579	hsa_circ_ESPL1	ESPL1	infantile pneumonia	MONDO:0005249	pneumonia	up-regulated	RT-qPCR	"In an LPS-induced WI-38 cell model of infantile pneumonia-related inflammatory injury, circ_0026579 is up-regulated and promotes inflammation/oxidative stress and apoptosis. Mechanistically, circ_0026579 sponges miR-24-3p to increase IGF2 expression, and circ_0026579 knockdown alleviates inflammatory injury via the miR-24-3p/IGF2 axis."	0.7009
35145563	Journal of genomics	2022	Circ-0036602 Acts As a Sponge of MiR-34a-5p and MiR-431-5p to Promote Cervical Cancer Proliferation and Invasion.	hsa_circ_0036602	circ0036602	hsa_circ_ZNF592	ZNF592	Cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"circ0036602 is upregulated in HPV-16 positive cervical cancer and promotes proliferation, migration, and invasion. Mechanistically, it functions as a ceRNA sponging miR-34a-5p and miR-431-5p to derepress HMGB1, and high circ0036602 is associated with poorer survival."	0.853
35148669	Bioengineered	2022	Circular RNA HIPK3 aggravates sepsis-induced acute kidney injury via modulating the microRNA-338/forkhead box A1 axis.	hsa_circ_0000284	circHIPK3	hsa_circ_HIPK3	HIPK3	sepsis-induced acute kidney injury	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in serum from septic AKI patients and in LPS-treated HK2 cells. It predominantly localizes to the cytoplasm and aggravates LPS-induced HK2 cell injury by sponging miR-338, thereby relieving miR-338-mediated suppression of FOXA1. circHIPK3 knockdown attenuates apoptosis, inflammation and oxidative stress and improves cell viability, suggesting potential biomarker/therapeutic relevance in sepsis-induced AKI."	0.7795
35148775	Molecular cancer	2022	Tumor-suppressive circRHOBTB3 is excreted out of cells via exosome to sustain colorectal cancer cell fitness.	hsa_circ_0007444	circRHOBTB3	hsa_circ_RHOBTB3	RHOBTB3	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	dysregulated	RT-qPCR; RNA-seq	"circRHOBTB3 (hsa_circ_0007444) is down-regulated in CRC tumor tissues but elevated in patient serum exosomes. Functionally, circRHOBTB3 suppresses CRC proliferation, migration/invasion, EMT and metastasis by regulating metabolism and ROS, partly through binding ENO1/ENO2, and it is sorted into exosomes via SNF8-dependent motifs; blocking its exosomal export and/or boosting its circularization with ASOs enhances antitumor effects."	0.8814
35151325	Cancer cell international	2022	Identification of key serum biomarkers for the diagnosis and metastatic prediction of osteosarcoma by analysis of immune cell infiltration.	hsa_circ_0010220				osteosarcoma / OS	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; Microarray	hsa-circ-0010220 is down-regulated in osteosarcoma patient serum and was proposed as a serum diagnostic biomarker. It is part of an immune cell infiltration-associated ceRNA network (circRNA_miRNA_mRNA) used to build a combined diagnostic model (AUC 0.928).	0.5047
35152837	Bioengineered	2022	Luteolin activates M2 macrophages and suppresses M1 macrophages by upregulation of hsa_circ_0001326 in THP-1 derived macrophages.	hsa_circ_0001326	circ_ 0001326	hsa_circ_PHLDB2	PHLDB2	asthma	MONDO:0004979	asthma	up-regulated	RT-qPCR	"In THP-1-derived macrophages, luteolin upregulates hsa_circ_0001326, which is required for luteolin-induced polarization changes. hsa_circ_0001326 modulates macrophage polarization through the hsa-miR-136-5p/USP4 axis, supported by knockdown, inhibitor rescue, and luciferase assays."	0.5416
35152839	Bioengineered	2022	Circular RNA CDK6 suppresses cervical cancer proliferation and metastasis by sponging miR-449a.		circRNA CDK6 / circCDK6	hsa_circ_CDK6	CDK6	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circCDK6 is up-regulated in cervical cancer cell lines and mainly localizes in the cytoplasm. Functional assays show that circCDK6 supports proliferation, migration/invasion and EMT, and it directly sponges miR-449a; circCDK6 knockdown increases miR-449a and suppresses malignant phenotypes and EMT marker changes."	0.7449
35153295	Signal transduction and targeted therapy	2022	Nuclear genome-derived circular RNA circPUM1 localizes in mitochondria and regulates oxidative phosphorylation in esophageal squamous cell carcinoma.	hsa_circ_0011240	circPUM1	hsa_circ_PUM1	PUM1	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; Northern Blot; RNA-seq	"In ESCC, circPUM1 (hsa_circ_0011240) is upregulated under hypoxia-like conditions and supports tumor growth. It localizes to mitochondria, binds UQCRC2 and modulates complex III assembly (with UQCRC1), thereby promoting OXPHOS/ATP production, maintaining mitochondrial homeostasis, and suppressing AMPK-associated caspase3/GSDME-mediated pyroptosis. Higher circPUM1 levels are associated with worse overall survival in ESCC patients."	0.8772
35154259	Frontiers in genetics	2021	Circular RNA CDR1as Alleviates Cisplatin-Based Chemoresistance by Suppressing MiR-1299 in Ovarian Cancer.	hsa_circ_0001946	CDR1as / ciRS-7	hsa_circ_CDR1		ovarian cancer / OC	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR; Microarray	"CDR1as is down-regulated in ovarian cancer and further reduced in cisplatin-resistant OC cells/tissues. Functionally, CDR1as enhances cisplatin sensitivity by inhibiting proliferation, migration and invasion and promoting apoptosis, largely through a ceRNA axis where CDR1as sponges miR-1299 to relieve repression of PPP1R12B, with knockdown associated with Akt/mTOR activation."	0.7302
35154330	Stem cells international	2022	Identification of circRNA Expression Profiles in BMSCs from Glucocorticoid-Induced Osteoporosis Model.		circARSB	rno_circ_Arsb	Arsb	glucocorticoid-induced osteoporosis / GIOP	MONDO:0000757	glucocorticoid-induced osteoporosis	up-regulated	RT-qPCR; RNA-seq	"circARSB is significantly up-regulated in BMSCs from the rat GIOP model. Knockdown experiments indicate circARSB suppresses osteogenic differentiation, and it is proposed to act via a circRNA-targeted miRNA-mRNA (miRNA sponge) mechanism."	0.5623
35154330	Stem cells international	2022	Identification of circRNA Expression Profiles in BMSCs from Glucocorticoid-Induced Osteoporosis Model.		circAKT3	rno_circ_Akt3	Akt3	glucocorticoid-induced osteoporosis / GIOP	MONDO:0000757	glucocorticoid-induced osteoporosis	up-regulated	RT-qPCR; RNA-seq	circAKT3 is significantly up-regulated in BMSCs from the rat GIOP model and is included among key dysregulated circRNAs. Its mechanism is proposed as a circRNA-targeted miRNA-mRNA (miRNA sponge) axis based on predicted circRNA-miRNA networks.	0.4032
35154330	Stem cells international	2022	Identification of circRNA Expression Profiles in BMSCs from Glucocorticoid-Induced Osteoporosis Model.		circPTEN	rno_circ_Pten	Pten	glucocorticoid-induced osteoporosis / GIOP	MONDO:0000757	glucocorticoid-induced osteoporosis	down-regulated	RT-qPCR; RNA-seq	"circPTEN is down-regulated in BMSCs from the rat GIOP model. Functional knockdown suggests circPTEN supports osteogenic differentiation, and it is proposed to function within a circRNA-targeted miRNA-mRNA (miRNA sponge) network."	0.4997
35154330	Stem cells international	2022	Identification of circRNA Expression Profiles in BMSCs from Glucocorticoid-Induced Osteoporosis Model.		circTRPM7	rno_circ_Trpm7	Trpm7	glucocorticoid-induced osteoporosis / GIOP	MONDO:0000757	glucocorticoid-induced osteoporosis	down-regulated	RT-qPCR; RNA-seq	circTRPM7 is down-regulated in BMSCs from the rat GIOP model. The study proposes it participates in a circRNA-targeted miRNA-mRNA (miRNA sponge) regulatory network based on computational prediction.	0.4032
35154515	Disease markers	2022	hsa_circ_0139402 Promotes Bladder Cancer Progression by Regulating hsa-miR-326/PAX8 Signaling.	hsa_circ_0139402				bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0139402 is up-regulated in bladder cancer tissues/cell lines and promotes malignant phenotypes (proliferation, migration, invasion and EMT). Mechanistically, it functions as a ceRNA that binds hsa-miR-326 to relieve repression of PAX8, thereby driving bladder cancer progression."	0.807
35155186	Frontiers in oncology	2021	Identification of Circular RNA-Based Immunomodulatory Networks in Colorectal Cancer.	hsa_circ_0000511		hsa_circ_RPPH1	RPPH1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000511 (RPPH1-derived) is identified as a co-upregulated circRNA in CRC and incorporated into a predicted ceRNA subnetwork linking it to hsa-miR-296-5p and hsa-miR-1976 with downstream hub genes NCAM1, CD44 and SYP. Its expression is supported by GEO differential expression and qRT-PCR detection in CRC cell lines."	0.4032
35155186	Frontiers in oncology	2021	Identification of Circular RNA-Based Immunomodulatory Networks in Colorectal Cancer.	hsa_circ_0000512		hsa_circ_RPPH1	RPPH1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000512 is a co-upregulated RPPH1-derived circRNA in CRC identified from GEO data and incorporated into a predicted ceRNA subnetwork, potentially sponging hsa-miR-296-5p and hsa-miR-1976 to affect NCAM1, CD44, and SYP. It is detectable by qRT-PCR in CRC cell lines with variable/undetectable expression across lines."	0.4032
35155186	Frontiers in oncology	2021	Identification of Circular RNA-Based Immunomodulatory Networks in Colorectal Cancer.	hsa_circ_0000514		hsa_circ_RPPH1	RPPH1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000514 is a co-upregulated RPPH1-derived circRNA in CRC identified from GEO data and incorporated into a predicted ceRNA subnetwork, potentially sponging hsa-miR-296-5p and hsa-miR-1976 to affect NCAM1, CD44 and SYP. qRT-PCR shows higher expression in CRC cell lines compared with NCM-460."	0.4032
35155186	Frontiers in oncology	2021	Identification of Circular RNA-Based Immunomodulatory Networks in Colorectal Cancer.	hsa_circ_0000515		hsa_circ_RPPH1	RPPH1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000515 is a co-upregulated RPPH1-derived circRNA in CRC. It participates in the predicted ceRNA subnetwork through multiple miRNAs (including hsa-miR-326 and hsa-miR-1296-5p) to hub genes (e.g., WNT5A, POLA1), and is also predicted to bind immune-related RBPs/proteins including ZC3H10, SAMD4A and ENOX1. Its expression is detected by qRT-PCR in a subset of CRC cell lines."	0.4032
35155186	Frontiers in oncology	2021	Identification of Circular RNA-Based Immunomodulatory Networks in Colorectal Cancer.	hsa_circ_0000517		hsa_circ_RPPH1	RPPH1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000517 is a co-upregulated RPPH1-derived circRNA in CRC identified from microarray data and detected by qRT-PCR in CRC cell lines. It is included in the predicted ceRNA subnetwork, potentially sponging hsa-miR-1306-5p, hsa-miR-326, and hsa-miR-1296-5p to regulate NCAPG, WNT5A, and POLA1."	0.4032
35155186	Frontiers in oncology	2021	Identification of Circular RNA-Based Immunomodulatory Networks in Colorectal Cancer.	hsa_circ_0000518		hsa_circ_RPPH1	RPPH1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000518 is a co-upregulated RPPH1-derived circRNA in CRC, detected by qRT-PCR with higher expression in several CRC cell lines than NCM-460. It is part of a predicted ceRNA subnetwork, potentially sponging hsa-miR-1306-5p, hsa-miR-326 and hsa-miR-1296-5p to regulate NCAPG, WNT5A and POLA1."	0.4032
35155186	Frontiers in oncology	2021	Identification of Circular RNA-Based Immunomodulatory Networks in Colorectal Cancer.	hsa_circ_0000519		hsa_circ_RPPH1	RPPH1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	hsa_circ_0000519 is a co-upregulated RPPH1-derived circRNA in CRC and shows higher expression across CRC cell lines than normal NCM-460 by qRT-PCR. It is included in the predicted ceRNA subnetwork via the hsa-miR-1296-5p_POLA1 axis.	0.4032
35155186	Frontiers in oncology	2021	Identification of Circular RNA-Based Immunomodulatory Networks in Colorectal Cancer.	hsa_circ_0000520		hsa_circ_RPPH1	RPPH1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000520 is a co-upregulated RPPH1-derived circRNA in CRC, detected by qRT-PCR with higher expression in multiple CRC cell lines than NCM-460. It is included in the predicted ceRNA subnetwork via the hsa-miR-1296-5p_POLA1 axis."	0.4032
35156507	Bioengineered	2022	Circular CDC like kinase 1 suppresses cell apoptosis through miR-18b-5p/Y-box protein 2 axis in oral squamous cell carcinoma.		circular-CDC like kinase 1	hsa_circ_CLK1		oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circ-CLK1 is up-regulated in OSCC patient samples and OSCC cell lines. Functionally, circ-CLK1 promotes viability/proliferation and suppresses apoptosis, at least partly by sponging miR-18b-5p to relieve repression of YBX2."	0.7032
35156517	Bioengineered	2022	Effect of circRNA_FOXO3 rs12196996 polymorphism and FOXO3 rs2232365 polymorphism on survival rate and severity of intensive care unit-acquired sepsis.			hsa_circ_FOXO3	FOXO3	sepsis	MONDO:0005229	bacterial infectious disease with sepsis	dysregulated	RT-qPCR	"In ICU-acquired sepsis patient samples, circRNA_FOXO3 expression differs by rs12196996/rs2232365 genotype combinations. Mechanistically, miR-23a suppresses circRNA_FOXO3 (and FOXO3), and circRNA_FOXO3 knockdown alleviates LPS-induced loss of viability and pro-inflammatory cytokine dysregulation in HUVECs, linking this axis to sepsis severity and survival."	0.6762
35156900	Bioengineered	2022	CircMMD_007 promotes oncogenic effects in the progression of lung adenocarcinoma through microRNA-197-3p/protein tyrosine phosphatase non-receptor type 9 axis.		hsa_circMMD_007	hsa_circ_UBAP2	UBAP2	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"circMMD_007 is up-regulated in lung adenocarcinoma and its higher level associates with more advanced clinical stages/metastasis. Functionally, circMMD_007 promotes tumor cell growth, migration/invasion, and increases chemotherapy drug survival, partly by sponging miR-197-3p to relieve repression of PTPN9 (circMMD_007/miR-197-3p/PTPN9 axis)."	0.8119
35163373	International journal of molecular sciences	2022	Heroin Regulates Orbitofrontal Circular RNAs.		circGrin2b / rno_circRNA_011731	rno_circ_Grin2b	Grin2b	opioid use disorder (OUD) / heroin exposure / heroin self-administration	MONDO:0001225	opioid abuse	up-regulated	RT-qPCR; Microarray	"circGrin2b is a heroin-responsive circRNA upregulated in rat OFC after heroin self-administration (validated by qPCR). It is predicted to bind multiple miRNAs, suggesting a potential miRNA-sponging role in heroin-induced neurobiological adaptations."	0.5922
35163373	International journal of molecular sciences	2022	Heroin Regulates Orbitofrontal Circular RNAs.		circAnks1a / rno_circRNA_009909	rno_circ_Anks1a	Anks1a	opioid use disorder (OUD) / heroin exposure / heroin self-administration	MONDO:0001225	opioid abuse	up-regulated	RT-qPCR; Microarray	"circAnks1a is upregulated in rat OFC after heroin self-administration (validated by qPCR in both sexes) and is not induced by sucrose, suggesting heroin-reward specificity. It is predicted to bind several miRNAs, consistent with a potential miRNA-sponge role."	0.5922
35163373	International journal of molecular sciences	2022	Heroin Regulates Orbitofrontal Circular RNAs.		circSlc24a2 / rno_circRNA_012370	rno_circ_Slc24a2	Slc24a2	opioid use disorder (OUD) / heroin exposure / heroin self-administration	MONDO:0001225	opioid abuse	up-regulated	RT-qPCR; Microarray	"circSlc24a2 is upregulated in rat OFC following heroin self-administration and is not induced by sucrose, suggesting heroin-reward specificity. Its regulation is proposed to be independent of host-gene mRNA changes and it is predicted to interact with multiple miRNAs."	0.5922
35163373	International journal of molecular sciences	2022	Heroin Regulates Orbitofrontal Circular RNAs.		circAdcy5 / rno_circRNA_003235	rno_circ_Adcy5	Adcy5	opioid use disorder (OUD) / heroin exposure / heroin self-administration	MONDO:0001225	opioid abuse	up-regulated	RT-qPCR; Microarray	"circAdcy5 is upregulated in rat OFC after heroin self-administration and is not induced by sucrose, suggesting heroin-reward specificity. It is predicted to bind multiple let-7 family miRNAs and may be partly co-regulated with linear Adcy5 in females."	0.5922
35163373	International journal of molecular sciences	2022	Heroin Regulates Orbitofrontal Circular RNAs.		circUbe2cbp / rno_circRNA_016706	rno_circ_Ube2cbp	Ube2cbp	opioid use disorder (OUD) / heroin exposure / heroin self-administration	MONDO:0001225	opioid abuse	up-regulated	RT-qPCR; Microarray	"circUbe2cbp is a heroin-responsive circRNA upregulated in rat OFC after heroin self-administration (qPCR-validated) and is also upregulated by sucrose reward in males, implying a broader reward-response role. It is predicted to bind several miRNAs consistent with a potential miRNA-sponge mechanism."	0.5922
35163797	International journal of molecular sciences	2022	The Competitive Endogenous RNA (ceRNA) Regulation in Porcine Alveolar Macrophages (3D4/21) Infected by Swine Influenza Virus (H1N1 and H3N2).		novel_circ_0004733			swine influenza virus infection	MONDO:0005460	swine influenza	down-regulated	RT-qPCR; RNA-seq	"In SIV (H1N1/H3N2) infected porcine alveolar macrophages (3D4/21), novel_circ_0004733 is down-regulated and mainly localized in the cytoplasm. It functions as a ceRNA/miRNA sponge for ssc-miR-10391 to modulate MAN2A1 expression, thereby influencing viral replication markers (M/NP) and host immune readouts such as IFN-gamma."	0.4713
35164758	Molecular cancer	2022	Exosomal circLPAR1 functions in colorectal cancer diagnosis and tumorigenesis through suppressing BRD4 via METTL3-eIF3h interaction.	hsa_circ_0087960	circLPAR1	hsa_circ_LPAR1	LPAR1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; ISH; RNA-seq	"Exosomal circLPAR1 is down-regulated in CRC tissues and plasma exosomes and can serve as a CRC-specific diagnostic biomarker. Functionally, exosomal circLPAR1 inhibits malignant phenotypes and tumor growth by binding eIF3h and disrupting METTL3-eIF3h-dependent translation of BRD4."	0.8844
35164763	Cancer cell international	2022	Circular RNA circ_IRAK3 contributes to tumor growth through upregulating KIF2A via adsorbing miR-603 in breast cancer.	hsa_circ_0005505		hsa_circ_IRAK3	IRAK3	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_IRAK3 (hsa_circ_0005505) is up-regulated in breast cancer and promotes malignant phenotypes (proliferation, colony formation, migration/invasion, cell-cycle progression) while inhibiting apoptosis, and enhances tumor growth in vivo. It functions as a ceRNA by sponging miR-603 to upregulate KIF2A. High circ_IRAK3 expression is associated with worse overall survival and adverse clinicopathologic features."	0.8571
35164771	Molecular cancer	2022	METTL14-mediated m6A modification of circORC5 suppresses gastric cancer progression by regulating miR-30c-2-3p/AKT1S1 axis.	hsa_circ_0007612	circORC5	hsa_circ_ORC5	ORC5	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; ISH; Microarray	"In gastric cancer, circORC5 is up-regulated and mainly localized in the cytoplasm. It promotes proliferation and invasion by sponging miR-30c-2-3p, thereby increasing downstream targets including AKT1S1 (and EIF4B); METTL14-mediated m6A modification reduces circORC5 expression and suppresses GC progression."	0.84
35164778	World journal of surgical oncology	2022	Construction of a circRNA-miRNA-mRNA network based on differentially co-expressed circular RNA in gastric cancer tissue and plasma by bioinformatics analysis.	hsa_circ_0001013		hsa_circ_KIAA1841	KIAA1841	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001013 is up-regulated in gastric cancer tissue and plasma (microarray) and shows higher expression in SGC-7901 than GES-1 (RT-qPCR). Bioinformatics predicts it functions as a ceRNA, forming a core circRNA-miRNA-mRNA network with 10 miRNAs and hub genes enriched in apoptosis- and PI3K-Akt-related pathways, suggesting a key role in GC pathogenesis."	0.3684
35164778	World journal of surgical oncology	2022	Construction of a circRNA-miRNA-mRNA network based on differentially co-expressed circular RNA in gastric cancer tissue and plasma by bioinformatics analysis.	hsa_circ_0007376		hsa_circ_MAP2K2	MAP2K2	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0007376 is up-regulated in gastric cancer tissue and plasma datasets and shows higher expression in SGC-7901 than GES-1 by RT-qPCR. It is included in the predicted circRNA-miRNA-mRNA network as a putative ceRNA, but no specific functional mechanism was experimentally validated."	0.3684
35164778	World journal of surgical oncology	2022	Construction of a circRNA-miRNA-mRNA network based on differentially co-expressed circular RNA in gastric cancer tissue and plasma by bioinformatics analysis.	hsa_circ_0043947		hsa_circ_BRCA1	BRCA1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0043947 is up-regulated in gastric cancer tissue and plasma datasets and is higher in SGC-7901 than GES-1 by RT-qPCR. It is incorporated into a predicted ceRNA (circRNA-miRNA-mRNA) network via bioinformatics, but no dedicated functional mechanism is experimentally validated in this study."	0.3684
35165927	Journal of clinical laboratory analysis	2022	Expression and clinical significance of circular RNA hsa_circ_0003416 in pediatric pulmonary arterial hypertension associated with congenital heart disease.	hsa_circ_0003416		hsa_circ_TMSB4X	TMSB4X	pulmonary arterial hypertension / PAH	MONDO:0015924	pulmonary arterial hypertension	down-regulated	RT-qPCR; Microarray	"hsa_circ_0003416 is down-regulated in plasma of pediatric PAH-CHD patients and shows diagnostic potential (AUC 0.721), also acting as an independent predictor of PAH-CHD and correlating negatively with BNP. Mechanistically, the study suggests (via in silico analysis) that it may participate in PAH-related processes through a ceRNA-like interaction with multiple miRNAs, with predicted involvement of PI3K-AKT and TGF-beta signaling."	0.6841
35166026	Thoracic cancer	2022	Cisplatin resistance and malignant behaviors of lung cancer cells are promoted by circ_0002360 via targeting miR-6751-3p to regulate the expression of ZNF300.	hsa_circ_0002360	circ_0002360	hsa_circ_RUNX1		lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circ_0002360 is upregulated in cisplatin-resistant lung cancer tissues/cells and promotes malignant phenotypes and DDP resistance. Mechanistically, it acts as a ceRNA by sponging miR-6751-3p to increase ZNF300 expression, thereby enhancing drug resistance and tumor progression in vitro and in xenograft models."	0.7761
35166172	Bioengineered	2022	circRNA_0000285 knockdown suppresses viability and promotes apoptosis of cervical cancer cells by sponging microRNA-654-3p.	hsa_circ_0000285	circRNA_0000285			Cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"In cervical cancer, circRNA_0000285 is up-regulated and directly binds (sponges) miR-654-3p. Silencing circRNA_0000285 reduces cervical cancer cell viability and increases apoptosis, accompanied by decreased Bcl-2 and increased Bax, and these effects are reversed by miR-654-3p inhibition."	0.6772
35167195	Thoracic cancer	2022	Circ_0010235 facilitates lung cancer development and immune escape by regulating miR-636/PDL1 axis.	hsa_circ_0010235	circ_0010235	hsa_circ_ALDH4A1	ALDH4A1	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circ_0010235 is up-regulated in lung cancer tissues/cells and is associated with worse survival. Functionally, it promotes proliferation, invasion, tumor growth and immune escape while inhibiting apoptosis, mainly by sponging miR-636 to upregulate PDL1."	0.8341
35168468	Bioengineered	2022	Circular RNA circ_0068464 combined with microRNA-383 regulates Wnt/beta-catenin pathway to promote the progression of colorectal cancer.	hsa_circ_0068464	circ_0068464			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq; Microarray	"circ_0068464 is up-regulated in colorectal cancer and acts as an oncogenic circRNA. It promotes CRC cell proliferation/migration/invasion and inhibits apoptosis by binding miR-383 and enhancing Wnt/beta-catenin pathway activity, and its knockdown suppresses tumor growth and lung metastasis in vivo."	0.7396
35168653	Journal of ovarian research	2022	CircCDK17 knockdown inhibits tumor progression and cell glycolysis by downregulaing YWHAZ expression through sponging miR-1294 in cervical cancer.		circ_101119	hsa_circ_CDK17	CDK17	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; RNA-seq	"circCDK17 is up-regulated in cervical cancer tissues/cells and promotes malignant phenotypes and glycolysis. Mechanistically, it functions as a ceRNA by sponging miR-1294 to increase YWHAZ expression, thereby enhancing proliferation/migration/invasion and reducing apoptosis; circCDK17 knockdown suppresses tumor growth in a HeLa xenograft model."	0.7893
35170199	Journal of cellular and molecular medicine	2022	Hsa_circ_0003945 promotes progression of hepatocellular carcinoma by mediating miR-34c-5p/LGR4/beta-catenin axis activity.	hsa_circ_0003945	Circ_0003945	hsa_circ_UBAP2	UBAP2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"Hsa_circ_0003945 (Circ_0003945), derived from UBAP2, is up-regulated in HCC tissue and also elevated in patient plasma. It promotes HCC cell proliferation/migration/invasion and xenograft growth by sponging miR-34c-5p to increase LGR4 and activate Wnt/beta-catenin signaling (e.g., c-Myc, Cyclin D1)."	0.8707
35170372	Bioengineered	2022	Circ_0020123 enhances the cisplatin resistance in non-small cell lung cancer cells partly by sponging miR-140-3p to regulate homeobox B5 (HOXB5).	hsa_circ_0020123	Circ_0020123			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0020123 is up-regulated in DDP-resistant NSCLC cells and enhances cisplatin resistance. Mechanistically, it sponges miR-140-3p to increase HOXB5 expression, thereby promoting malignant behaviors and tumor growth under cisplatin treatment."	0.5634
35170374	Bioengineered	2022	Hsa_circ_0005230 is up-regulated and promotes gastric cancer cell invasion and migration via regulating the miR-1299/RHOT1 axis.	hsa_circ_0005230		hsa_circ_DNM3OS	DNM3OS	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"In gastric cancer, hsa_circ_0005230 is up-regulated in tissues and cell lines and promotes proliferation, invasion and migration. Mechanistically, it mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-1299 to increase RHOT1 expression, thereby enhancing EMT-related malignant phenotypes and associating with poor prognosis."	0.8201
35172672	Bioengineered	2022	Circular RNA VMA21 ameliorates lung injury in septic rat via targeting microRNA-497-5p/CD2-associated protein axis.		circVMA21	hsa_circ_VMA21	VAM21	sepsis-induced acute kidney injury	MONDO:0002492	acute kidney injury	down-regulated	RT-qPCR	"circVMA21 is down-regulated in sepsis-induced lung injury models. Its overexpression alleviates lung injury by reducing apoptosis, inflammation and oxidative stress, acting as a ceRNA that sponges miR-497-5p to restore CD2AP expression."	0.7052
35173146	Cell death discovery	2022	Circ-AFAP1 promote clear cell renal cell carcinoma growth and angiogenesis by the Circ-AFAP1/miR-374b-3p/VEGFA signaling axis.		Circ-AFAP1 / circAFAP1	hsa_circ_AFAP1	AFAP1	clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circAFAP1 is up-regulated in ccRCC and promotes tumor cell proliferation and angiogenesis. It functions as a ceRNA by sponging miR-374b-3p to increase VEGFA expression and activate Ras/ERK signaling, and higher circAFAP1 is associated with worse overall survival."	0.8847
35174071	Frontiers in oncology	2021	Investigating Urinary Circular RNA Biomarkers for Improved Detection of Renal Cell Carcinoma.		circEGLN3	hsa_circ_EGLN3	EGLN3	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	down-regulated	RT-qPCR	circEGLN3 is detectable in urinary sediment and is down-regulated in urine from ccRCC patients compared with healthy controls. Urinary circEGLN3 shows diagnostic potential for distinguishing cancer vs non-neoplastic individuals (AUC 0.71).	0.6238
35174071	Frontiers in oncology	2021	Investigating Urinary Circular RNA Biomarkers for Improved Detection of Renal Cell Carcinoma.		circSOD2	hsa_circ_SOD2	SOD2	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	down-regulated	RT-qPCR	circSOD2 is detectable in urinary sediment and is down-regulated in urine from ccRCC patients compared with healthy controls (also lower in benign tumors vs controls). Urinary circSOD2 has diagnostic value for distinguishing cancer vs non-neoplastic individuals (AUC 0.68).	0.6238
35174071	Frontiers in oncology	2021	Investigating Urinary Circular RNA Biomarkers for Improved Detection of Renal Cell Carcinoma.		circACAD11	hsa_circ_ACAD11	ACAD11	clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	down-regulated	RT-qPCR	"Urinary circACAD11 is measurable by RT-qPCR and is lower in ccRCC patients who have metastasis at the time of diagnosis compared with those without metastasis, suggesting potential association with metastatic status."	0.5129
35174214	Frontiers in molecular biosciences	2022	Comprehensive Analysis of Circular RNA Expression in ceRNA Networks and Identification of the Effects of hsa_circ_0006867 in Keloid Dermal Fibroblasts.	hsa_circ_0006867	hsa_circRNA_0006867	hsa_circ_LRBA	LRBA	keloid	MONDO:0005348	keloid	up-regulated	RT-qPCR; Microarray	"hsa_circ_0006867 is up-regulated in keloid dermal fibroblasts and promotes fibroblast proliferation, migration, and invasion in vitro. It mainly localizes to the cytoplasm and functions as a miRNA sponge, with experimental support for binding miR-29a-5p and association with AGO2, suggesting a potential miR-29a-5p/KCCN3 regulatory axis in keloid progression."	0.7372
35174214	Frontiers in molecular biosciences	2022	Comprehensive Analysis of Circular RNA Expression in ceRNA Networks and Identification of the Effects of hsa_circ_0006867 in Keloid Dermal Fibroblasts.	hsa_circ_0001055				keloid	MONDO:0005348	keloid	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001055 was validated by RT-qPCR as significantly up-regulated in keloid samples/cells compared with normal controls, but no specific downstream mechanism or functional assays were reported for this circRNA in this study."	0.3588
35174214	Frontiers in molecular biosciences	2022	Comprehensive Analysis of Circular RNA Expression in ceRNA Networks and Identification of the Effects of hsa_circ_0006867 in Keloid Dermal Fibroblasts.	hsa_circ_0073244				keloid	MONDO:0005348	keloid	up-regulated	RT-qPCR; Microarray	"hsa_circ_0073244 was validated by RT-qPCR as significantly up-regulated in keloid samples/cells compared with normal controls, but no specific downstream mechanism or functional assays were reported for this circRNA in this study."	0.3588
35174214	Frontiers in molecular biosciences	2022	Comprehensive Analysis of Circular RNA Expression in ceRNA Networks and Identification of the Effects of hsa_circ_0006867 in Keloid Dermal Fibroblasts.	hsa_circ_0004662				keloid	MONDO:0005348	keloid	down-regulated	RT-qPCR; Microarray	"hsa_circ_0004662 was validated by RT-qPCR as significantly down-regulated in keloid samples/cells compared with normal controls, but no specific downstream mechanism or functional assays were reported for this circRNA in this study."	0.3588
35174214	Frontiers in molecular biosciences	2022	Comprehensive Analysis of Circular RNA Expression in ceRNA Networks and Identification of the Effects of hsa_circ_0006867 in Keloid Dermal Fibroblasts.	hsa_circ_0000479	hsa_circRNA_000479	hsa_circ_EPSTI1	EPSTI1	keloid	MONDO:0005348	keloid	down-regulated	RT-qPCR; Microarray	"hsa_circ_0000479 (EPSTI1-derived) was validated by RT-qPCR as significantly down-regulated in keloid samples/cells compared with normal controls, but no specific downstream mechanism or functional assays were reported for this circRNA in this study."	0.3588
35174633	The Kaohsiung journal of medical sciences	2022	Icaritin-elevated circ_0000190 suppresses the malignant progression of multiple myeloma by targeting miR-301a.	hsa_circ_0000190				multiple myeloma / MM	MONDO:0009693	plasma cell myeloma	down-regulated	RT-qPCR	"circ_0000190 is down-regulated in multiple myeloma bone marrow and MM cell lines, and Icaritin upregulates it. Functionally, circ_0000190 acts as a tumor suppressor by sponging miR-301a, thereby reducing miR-301a-driven JAK1/STAT3 signaling and inhibiting MM cell cycle progression, migration/invasion while promoting apoptosis."	0.7074
35174654	Thoracic cancer	2022	Circ_0001955 plays a carcinogenic role in breast cancer via positively regulating GLUT1 via decoying miR-1299.	hsa_circ_0001955	circ_0001955	hsa_circ_CSNK1G1	CSNK1G1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circ_0001955 is up-regulated in breast cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes malignant phenotypes (proliferation, migration/invasion, angiogenesis, glycolysis) and inhibits apoptosis by sponging miR-1299, thereby de-repressing/positively regulating GLUT1."	0.7898
35174774	Bioengineered	2022	Regulation of microRNA miR-197-3p/CDC28 protein kinase regulatory subunit 1B (CKS1B) axis by Circular RNA hsa_circ_0000285 promotes glioma progression.	hsa_circ_0000285	circ_0000285			glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"hsa_circ_0000285 (circ_0000285) is up-regulated in glioma tissues/cells, mainly localized in the cytoplasm, and promotes glioma progression. Mechanistically, it sponges miR-197-3p to relieve repression of CKS1B, thereby enhancing proliferation and invasion while reducing apoptosis, and it supports tumor growth in a xenograft model."	0.762
35176309	Gastroenterology	2022	Circular RNA ANAPC7 Inhibits Tumor Growth and Muscle Wasting via PHLPP2-AKT-TGF-beta Signaling Axis in Pancreatic Cancer.	hsa_circ_0005785		hsa_circ_ANAPC7	ANAPC7	pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	down-regulated	RT-qPCR; Microarray	"circANAPC7 is down-regulated in pancreatic cancer and functions as a tumor suppressor and anti-cachexia factor. It sponges miR-373 to de-repress PHLPP2, leading to reduced AKT phosphorylation and decreased cyclin D1-driven proliferation. Through the PHLPP2/AKT/STAT5 axis it reduces TGF-beta expression/secretion, alleviating muscle wasting, and participates in a CREB_miR-373_PHLPP2 feed-forward loop linked to ZIP4 signaling."	0.8794
35177076	Reproductive biology and endocrinology : RB&E	2022	Circ_FURIN knockdown assuages Testosterone-induced human ovarian granulosa-like tumor cell disorders by sponging miR-423-5p to reduce MTM1 expression in polycystic ovary syndrome.	hsa_circ_0036881		hsa_circ_FURIN	FURIN	polycystic ovary syndrome / PCOS	MONDO:0008487	polycystic ovary syndrome	up-regulated	RT-qPCR	"circ_FURIN is up-regulated in PCOS ovarian cortex tissues and in testosterone-treated KGN cells. Functionally, circ_FURIN promotes testosterone-induced granulosa-like cell dysfunction by sponging miR-423-5p and thereby increasing MTM1 expression, leading to reduced proliferation and increased apoptosis."	0.8275
35178103	Evidence-based complementary and alternative medicine : eCAM	2022	Comprehensive circRNA Analyses in Human Vertebrae of GIOP and Its Molecular Mechanism.	hsa_circ_0004906				glucocorticoid-induced osteoporosis / GIOP	MONDO:0000757	glucocorticoid-induced osteoporosis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0004906 is significantly up-regulated in vertebral bone samples from GIOP patients versus controls and was validated by RT-qPCR. Its potential role is inferred from a predicted circRNA_miRNA interaction network and enrichment of targeted miRNAs in bone metabolism-related pathways (e.g., MAPK)."	0.585
35178103	Evidence-based complementary and alternative medicine : eCAM	2022	Comprehensive circRNA Analyses in Human Vertebrae of GIOP and Its Molecular Mechanism.	hsa_circ_0001172				glucocorticoid-induced osteoporosis / GIOP	MONDO:0000757	glucocorticoid-induced osteoporosis	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0001172 is significantly up-regulated in vertebral bone samples from GIOP patients and confirmed by RT-qPCR. The study suggests it may participate in GIOP through predicted circRNA_miRNA interactions and enrichment of target miRNAs in bone metabolism-related pathways.	0.585
35178103	Evidence-based complementary and alternative medicine : eCAM	2022	Comprehensive circRNA Analyses in Human Vertebrae of GIOP and Its Molecular Mechanism.	hsa_circ_0004276				glucocorticoid-induced osteoporosis / GIOP	MONDO:0000757	glucocorticoid-induced osteoporosis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0004276 is significantly up-regulated in GIOP vertebral bone and validated by RT-qPCR. It is included in a predicted circRNA_miRNA regulatory network, suggesting a potential miRNA-sponge role in GIOP."	0.585
35178103	Evidence-based complementary and alternative medicine : eCAM	2022	Comprehensive circRNA Analyses in Human Vertebrae of GIOP and Its Molecular Mechanism.	hsa_circ_0005729				glucocorticoid-induced osteoporosis / GIOP	MONDO:0000757	glucocorticoid-induced osteoporosis	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0005729 is significantly up-regulated in GIOP vertebral bone and validated by RT-qPCR. The paper implicates it in GIOP via a predicted circRNA_miRNA regulatory network and pathway enrichment of target miRNAs related to bone metabolism.	0.585
35178103	Evidence-based complementary and alternative medicine : eCAM	2022	Comprehensive circRNA Analyses in Human Vertebrae of GIOP and Its Molecular Mechanism.	hsa_circ_0006173				glucocorticoid-induced osteoporosis / GIOP	MONDO:0000757	glucocorticoid-induced osteoporosis	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0006173 is significantly down-regulated in GIOP vertebral bone and validated by RT-qPCR. It is analyzed within a predicted circRNA_miRNA interaction network; target-miRNA enrichment suggests involvement of metabolic and TORC1-related signaling in GIOP.	0.585
35178103	Evidence-based complementary and alternative medicine : eCAM	2022	Comprehensive circRNA Analyses in Human Vertebrae of GIOP and Its Molecular Mechanism.	hsa_circ_0007662				glucocorticoid-induced osteoporosis / GIOP	MONDO:0000757	glucocorticoid-induced osteoporosis	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0007662 is significantly down-regulated in GIOP vertebral bone and validated by RT-qPCR. The study places it in a predicted circRNA_miRNA regulatory network, implying a potential miRNA-sponge role relevant to bone metabolism-related pathways."	0.585
35178103	Evidence-based complementary and alternative medicine : eCAM	2022	Comprehensive circRNA Analyses in Human Vertebrae of GIOP and Its Molecular Mechanism.	hsa_circ_0001451				glucocorticoid-induced osteoporosis / GIOP	MONDO:0000757	glucocorticoid-induced osteoporosis	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001451 is significantly down-regulated in GIOP vertebral bone and validated by RT-qPCR. It is highlighted as highly connected in the predicted circRNA_miRNA network, suggesting a potential regulatory (miRNA sponge) role in GIOP."	0.585
35178103	Evidence-based complementary and alternative medicine : eCAM	2022	Comprehensive circRNA Analyses in Human Vertebrae of GIOP and Its Molecular Mechanism.	hsa_circ_0001564				glucocorticoid-induced osteoporosis / GIOP	MONDO:0000757	glucocorticoid-induced osteoporosis	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0001564 is significantly down-regulated in GIOP vertebral bone and validated by RT-qPCR. The paper suggests it may be involved in GIOP through predicted circRNA_miRNA interactions and enrichment of target miRNAs in metabolic/TORC1-related processes.	0.585
35178103	Evidence-based complementary and alternative medicine : eCAM	2022	Comprehensive circRNA Analyses in Human Vertebrae of GIOP and Its Molecular Mechanism.	hsa_circ_0108735				glucocorticoid-induced osteoporosis / GIOP	MONDO:0000757	glucocorticoid-induced osteoporosis	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0108735 is significantly down-regulated in GIOP vertebral bone and validated by RT-qPCR. It is included in the predicted circRNA_miRNA network, suggesting a potential miRNA-sponge regulatory role linked to bone metabolism-related processes."	0.585
35179220	Oncology reports	2022	circKL inhibits the growth and metastasis of kidney cancer by sponging miR_182_5p and upregulating FBXW7.	hsa_circ_0100312	circKL	hsa_circ_KL	KL	kidney cancer	MONDO:0002367	kidney cancer	down-regulated	RT-qPCR; Microarray	"circKL (hsa_circ_0100312) is downregulated in kidney cancer and functions as a tumor suppressor by inhibiting proliferation, migration, and metastasis in vitro and in xenograft models. Mechanistically, it predominantly localizes to the cytoplasm and sponges miR-182-5p to relieve repression of FBXW7, forming a circKL/miR-182-5p/FBXW7 ceRNA axis."	0.8512
35182060	Cell journal	2022	CircRNA-011235 Counteracts The Deleterious Effect of Irradiation Treatment on Bone Mesenchymal Stem Cells by Regulating The miR-741-3p/CDK6 Pathway.		circRNA-011235			irradiation-induced bone mesenchymal stem cells injury / TBI-induced BMSCs injury	MONDO:0033938	acute radiation syndrome	up-regulated	RT-qPCR	"In mouse BMSCs exposed to irradiation, circ-011235 is up-regulated and protects against irradiation-induced growth suppression. Mechanistically, it sponges miR-741-3p to relieve repression of CDK6, increasing cyclin D1 and promoting G1/S progression and proliferation."	0.6908
35184406	Clinical and translational medicine	2022	PRKAR2A-derived circular RNAs promote the malignant transformation of colitis and distinguish patients with colitis-associated colorectal cancer.	mmu_circ_0001109				colitis	MONDO:0005292	colitis	up-regulated	RT-qPCR; ISH; Microarray	"In mouse DSS-induced colitis and AOM/DSS-associated CAC, mmu_circ_0001109 is up-regulated and promotes inflammatory progression by activating Jak/STAT3 and NF-kappaB signaling."	0.6824
35184406	Clinical and translational medicine	2022	PRKAR2A-derived circular RNAs promote the malignant transformation of colitis and distinguish patients with colitis-associated colorectal cancer.	mmu_circ_0001845	mmu_circ_1845			colitis	MONDO:0005292	colitis	up-regulated	RT-qPCR; ISH; Microarray	"In the AOM/DSS mouse CAC model, mmu_circ_0001845 is up-regulated and promotes the colitis-to-carcinoma transition by activating Wnt/beta-catenin signaling."	0.599
35184406	Clinical and translational medicine	2022	PRKAR2A-derived circular RNAs promote the malignant transformation of colitis and distinguish patients with colitis-associated colorectal cancer.	hsa_circ_0124022		hsa_circ_PRKAR2A	PRKAR2A	colitis	MONDO:0005292	colitis	up-regulated	RT-qPCR	"hsa_circ_0124022 (PRKAR2A-derived) is up-regulated in CAC tissues versus UC/healthy controls, is associated with faster UC-to-carcinoma progression and poorer outcomes, and can activate Wnt signaling in CRC cells after overexpression."	0.6028
35184406	Clinical and translational medicine	2022	PRKAR2A-derived circular RNAs promote the malignant transformation of colitis and distinguish patients with colitis-associated colorectal cancer.	hsa_circ_0124028		hsa_circ_PRKAR2A	PRKAR2A	colitis	MONDO:0005292	colitis	up-regulated	RT-qPCR	"hsa_circ_0124028 (PRKAR2A-derived) is up-regulated in CAC tissues and is linked to shorter UC-to-carcinoma interval, clinicopathologic features (including TNM stage), and poor outcome; it can activate Wnt signaling in CRC cells after overexpression."	0.6418
35184406	Clinical and translational medicine	2022	PRKAR2A-derived circular RNAs promote the malignant transformation of colitis and distinguish patients with colitis-associated colorectal cancer.	hsa_circ_0124029		hsa_circ_PRKAR2A	PRKAR2A	colitis	MONDO:0005292	colitis	up-regulated	RT-qPCR	"hsa_circ_0124029 (PRKAR2A-derived) is up-regulated in CAC tissues, is associated with shorter UC-to-carcinoma duration and poor prognosis, and can activate Wnt signaling in CRC cells upon overexpression."	0.6418
35184419	"Cancer communications (London, England)"	2022	Essential roles of exosome and circRNA_101093 on ferroptosis desensitization in lung adenocarcinoma.		circRNA_101093 / cir93	hsa_circ_NUP107	NUP107	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"In LUAD, exosomal circRNA_101093 (cir93) is upregulated and maintains elevated intracellular cir93. cir93 binds to and increases FABP3, reducing AA availability and AA membrane incorporation (partly via NAT generation), which suppresses lipid peroxidation and desensitizes LUAD cells to ferroptosis; high cir93 is associated with poorer overall survival."	0.7932
35184658	Bioengineered	2022	The circular RNA circ_0030018/miR-136/migration and invasion enhancer 1 (MIEN1) axis promotes the progression of polycystic ovary syndrome.	hsa_circ_0030018	circ_0030018 / circ-POSTN	hsa_circ_POSTN	POSTN	polycystic ovary syndrome / PCOS	MONDO:0008487	polycystic ovary syndrome	up-regulated	RT-qPCR; Microarray	"circ_0030018 is up-regulated in ovarian granulosa cells from PCOS patients and in KGN/COV434 cells. Functionally, circ_0030018 promotes granulosa-cell proliferation, migration/invasion and EMT-like marker changes while inhibiting apoptosis, mainly by sponging miR-136 to de-repress MIEN1."	0.8237
35184688	Bioengineered	2022	"Circular RNA PIP5K1A act as microRNA-552-3p sponge to regulates inflammation, oxidative damage in glucolipotoxicity-induced pancreatic INS-1 beta-cells via Janus kinase 1."		circPIP5K1A		PIP5K1A	type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RT-qPCR	"circPIP5K1A is up-regulated in the serum of T2DM patients and induced by glucolipotoxicity in INS-1E cells. It mainly localizes to the cytoplasm and functions as a miR-552-3p sponge to modulate JAK1 and the JAK1/STAT3 pathway, promoting inflammation, oxidative stress, apoptosis, and beta-cell dysfunction."	0.7519
35186081	Journal of oncology	2022	CircRNA ACVR2A Sponges miR-1290 to Modulate Cell Progression in Gastric Cancer.		circACVR2A / CircRNA ACVR2A	hsa_circ_ACVR2A	ACVR2A	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circACVR2A is up-regulated in gastric cancer tissues and cell lines and suppresses GC cell proliferation, migration, and invasion. It functions by sponging miR-1290 and is linked to regulation of EMT markers (E-cadherin and Vimentin), suggesting potential biomarker relevance."	0.6811
35188072	Bioengineered	2022	CircRNA SOD2 motivates non-small cell lungs cancer advancement with EMT via acting as microRNA-2355-5p's competing endogenous RNA to mediate calmodulin regulated spectrin associated proteins-2.		circRNA SOD2 / CircSOD2	hsa_circ_SOD2	SOD2	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"CircSOD2 is up-regulated in NSCLC tissues and cell lines and promotes malignant phenotypes including proliferation, migration/invasion and EMT. Mechanistically, CircSOD2 functions as a ceRNA sponging miR-2355-5p to relieve repression of CAMSAP2, forming a CircSOD2/miR-2355-5p/CAMSAP2 axis."	0.7754
35189958	Journal of experimental & clinical cancer research : CR	2022	circCUL2 induces an inflammatory CAF phenotype in pancreatic ductal adenocarcinoma via the activation of the MyD88-dependent NF-kappaB signaling pathway.	hsa_circ_0000234	circCUL2	hsa_circ_CUL2	CUL2	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circCUL2 is up-regulated in PDAC stroma/CAFs and drives normal fibroblasts toward an inflammatory CAF (iCAF) phenotype. It acts as a ceRNA sponge for miR-203a-3p to increase MyD88 and activate NF-kappaB signaling, elevating IL6 secretion, which in turn activates STAT3 in PDAC cells to promote proliferation, migration/invasion, tumor growth and metastasis; high circCUL2 associates with poor patient survival."	0.8909
35190532	Cell death & disease	2022	CircNEIL3 mediates pyroptosis to influence lung adenocarcinoma radiotherapy by upregulating PIF1 through miR-1184 inhibition.	hsa_circ_0001460	circNEIL3	hsa_circ_NEIL3	NEIL3	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; RNA-seq	"In irradiated LUAD cells, circNEIL3 is downregulated and functions as a cytoplasmic ceRNA by sponging miR-1184 to upregulate PIF1. This axis modulates DNA damage/AIM2 inflammasome signaling to regulate radiation-induced pyroptosis and affects radiotherapy efficacy in vivo."	0.8366
35191420	Chinese medical journal	2022	circBIRC6 contributes to the development of non-small cell lung cancer via regulating microRNA-217/amyloid beta precursor protein binding protein 2 axis.		circBIRC6 / circRNA baculoviral inhibitor of apoptosis protein (IAP) repeat containing 6 (circBIRC6)	hsa_circ_BIRC6	BIRC6	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circBIRC6 is up-regulated in NSCLC tissues and cell lines and acts as an oncogenic circRNA. It mainly localizes to the cytoplasm and promotes proliferation/colony formation, migration/invasion/EMT, and tumor growth while inhibiting apoptosis by sponging miR-217 to upregulate APPBP2."	0.7631
35191807	Bioengineered	2022	Circular RNA triple functional domain promotes osteoarthritis' development by modulating the microRNA-136-5p/Nicotinamide phosphoribosyltransferase axis.		circTRIO / CircRNA triple functional domain (TRIO)	hsa_circ_TRIO	TRIO	osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circTRIO is up-regulated in osteoarthritis cartilage and in IL-1beta-treated chondrocytes. Functionally, circTRIO promotes OA-associated inflammation, apoptosis and matrix-degrading MMP expression while reducing chondrocyte viability. Mechanistically, it acts as a ceRNA that sponges miR-136-5p to increase NAMPT, forming the circTRIO/miR-136-5p/NAMPT axis."	0.6544
35196197	Bioengineered	2022	Circular RNA-UBE2D2 accelerates the proliferation and metastasis of non-small cell lung cancer cells via modulating microRNA-376a-3p/Eukaryotic Translation Initiation Factor 4gamma2 axis.		circ-UBE2D2 / circRNA UBE2D2	hsa_circ_UBE2D2	UBE2D2	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ-UBE2D2 is up-regulated in NSCLC tissues and cell lines and functions as an oncogenic circRNA by sponging miR-376a-3p to increase EIF4G2 expression. It promotes proliferation, migration and invasion while inhibiting apoptosis, and higher circ-UBE2D2 level is associated with advanced clinicopathologic features and poor prognosis."	0.6536
35196205	Bioengineered	2022	"Circular RNA SET domain protein 3 promotes nasopharyngeal carcinoma proliferation, cisplatin resistance, and protein kinase B / mammalian target of rapamycin pathway activation by modulating microRNA-147a expression."		circRNA SET domain protein 3	hsa_circ_SETD3		nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"circSETD3 is up-regulated in nasopharyngeal carcinoma and further elevated in cisplatin-resistant settings. It promotes proliferation, inhibits apoptosis, and enhances cisplatin resistance by sponging miR-147a and activating Akt/mTOR signaling, and its knockdown suppresses xenograft tumor growth and improves cisplatin response."	0.7548
35198554	Frontiers in cell and developmental biology	2022	Identification of Cardiac CircRNAs in Mice With CVB3-Induced Myocarditis.		mmucirc_016699	mmu_circ_Arhgap32	arhgap32	viral myocarditis / VM	MONDO:0023161	viral myocarditis	down-regulated	RT-qPCR; RNA-seq	"In CVB3-induced myocarditis (especially in susceptible A/J mice), circArhgap32 (mmucirc_016699) is down-regulated. Loss of circArhgap32 aggravates cardiomyocyte injury by reducing viability and promoting apoptosis and proinflammatory cytokine production, indicating a protective role in viral myocarditis-related cardiac dysfunction."	0.6853
35199365	Annals of the New York Academy of Sciences	2022	Circular RNA circ_0001459 accelerates hepatocellular carcinoma progression via the miR-6165/IGF1R axis.	hsa_circ_0001459	circ_0001459	hsa_circ_NEIL3	NEIL3	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ_0001459 is upregulated in hepatocellular carcinoma and mainly localizes to the cytoplasm. It promotes HCC proliferation, migration, invasion and metastasis by sponging miR-6165 to relieve repression of IGF1R, thereby enhancing EMT-related and Akt-related signaling; high circ_0001459 associates with worse overall survival."	0.8793
35199873	Journal of clinical laboratory analysis	2022	CircRNA_0008194 functions as a ceRNA to promote invasion of hepatocellular carcinoma via inhibiting miR-190a/AHNAK signaling pathway.	hsa_circ_0008194		hsa_circ_AHNAK	AHNAK	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0008194 is up-regulated in HCC tumor tissues and promotes invasion/metastasis and EMT in vitro. It functions as a ceRNA by sponging miR-190a, thereby increasing AHNAK expression."	0.7754
35200097	Bioengineered	2022	Circular RNA circHIPK3 is downregulated in diabetic cardiomyopathy and overexpression of circHIPK3 suppresses PTEN to protect cardiomyocytes from high glucose-induced cell apoptosis.		circHIPK3 / circRNA homeodomain-interacting protein kinase 3	hsa_circ_HIPK3	HIPK3	diabetic cardiomyopathy	MONDO:0004994	cardiomyopathy	down-regulated	RT-qPCR	"circHIPK3 is down-regulated in diabetic cardiomyopathy (and also decreased in diabetes). In AC16 cardiomyocytes under high glucose, circHIPK3 overexpression reduces PTEN mRNA/protein and suppresses high glucose-induced apoptosis, suggesting a protective role via negative regulation of PTEN."	0.5546
35200111	Bioengineered	2022	Circular RNA hsa_circ_0119412 contributes to tumorigenesis of gastric cancer via the regulation of the miR-1298-5p/zinc finger BED-type containing 3 (ZBED3) axis.	hsa_circ_0119412	hsa_circRNA_102958	hsa_circ_PER2	PER2	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	hsa_circ_0119412 is up-regulated in gastric cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes GC cell viability/invasion and tumor growth while inhibiting apoptosis by acting as a ceRNA sponge for miR-1298-5p to increase ZBED3 expression.	0.8119
35200157	Aging	2022	Circular RNA circSHPRH inhibits the malignant behaviors of bladder cancer by regulating the miR-942/BARX2 pathway.	hsa_circ_0001649	circSHPRH	hsa_circ_SHPRH	SHPRH	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"circSHPRH (hsa_circ_0001649) is down-regulated in bladder cancer and acts as a tumor suppressor. It sponges miR-942 to increase BARX2 expression, thereby inhibiting Wnt/beta-catenin signaling and reducing proliferation, migration, invasion, and in vivo tumor growth. Low circSHPRH expression is associated with advanced clinicopathological features and worse survival."	0.8285
35209946	Acta neuropathologica communications	2022	Medulloblastoma cerebrospinal fluid reveals metabolites and lipids indicative of hypoxia and cancer-specific RNAs.		circ_463 / ciRS-7	hsa_circ_CDR1AS	LINC00632	medulloblastoma / MB	MONDO:0007959	medulloblastoma	up-regulated	RT-qPCR; RNA-seq	circ_463 (ciRS-7/CDR1as) is significantly up-regulated in medulloblastoma patient CSF and was qRT-PCR validated as the most upregulated/abundant circRNA among the DE circRNAs. It may act as a miR-7 sponge and is proposed as a candidate CSF biomarker and potential oncogenic circRNA in this context.	0.3588
35210429	Cell death discovery	2022	The circular RNA hsa_circ_0001394 promotes hepatocellular carcinoma progression by targeting the miR-527/UBE2A axis.	hsa_circ_0001394	circTBC1D14	hsa_circ_TBC1D14	TBC1D14	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001394 (circTBC1D14) is up-regulated in HCC tissues/cells/plasma and mainly localized in the cytoplasm. It promotes HCC cell proliferation, migration, invasion and tumor growth by sponging miR-527, thereby relieving repression of UBE2A and affecting downstream MDM2/p53/Bcl2/Bax and EMT-related changes."	0.8658
35211158	Frontiers in genetics	2022	circEPS15 Overexpression in Hepatocellular Carcinoma Modulates Tumor Invasion and Migration.		circEPS15 / circRNA-100226	hsa_circ_EPS15	EPS15	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"circEPS15 (circRNA-100226) is down-regulated in HCC tissues and low expression is associated with poor overall survival. circEPS15 overexpression inhibits HCC cell migration/invasion and induces G2/M cell-cycle arrest, potentially via a ceRNA network and modulation of TJP1/CDH2/VIM signaling. It also contains an IRES-driven spanning-junction ORF that can be translated into a novel protein."	0.835
35211507	Frontiers in molecular biosciences	2021	Decreased Expression of circ_0000160 in Breast Cancer With Axillary Lymph Node Metastasis.	hsa_circ_0000160	circ_0000160	hsa_circ_SUCO	SUCO	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; RNA-seq	circ_0000160 is down-regulated in breast cancer tissues with axillary lymph node metastasis and shows diagnostic potential (AUC 0.7435) to distinguish ALNM-positive from ALNM-negative cases. Bioinformatics predicts circ_0000160 participates in a circRNA_miRNA_mRNA (ceRNA) network involving eight candidate miRNAs and cancer-related pathways such as cell cycle and JAK-STAT.	0.5047
35211755	International journal of oncology	2022	circ_LRP6 contributes to osteosarcoma progression by regulating the miR_141_3p/HDAC4/HMGB1 axis.		circ-LRP6 / circRNA low-density lipoprotein receptor-related protein 6	hsa_circ_LRP6	LRP6	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ-LRP6 is up-regulated in osteosarcoma tissues and cell lines and functions as an oncogenic circRNA. It sponges miR-141-3p to increase HDAC4 and HMGB1, thereby promoting osteosarcoma cell proliferation, migration, and invasion; high circ-LRP6 is associated with worse overall survival and shows diagnostic potential."	0.8168
35212145	CNS neuroscience & therapeutics	2022	Hsa_circ_0072309 enhances autophagy and TMZ sensitivity in glioblastoma.	hsa_circ_0072309		hsa_circ_LIFR	LIFR	glioblastoma / GBM	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR	"In glioblastoma, hsa_circ_0072309 is downregulated and higher expression is associated with better patient survival. Functionally, it promotes autophagy and increases TMZ sensitivity in p53 wild-type GBM by stabilizing p53 (reducing p53 ubiquitination) via miR-100 mediation, while showing little effect in p53-mutant GBM."	0.7537
35212425	Journal of clinical laboratory analysis	2022	Hsa_circ_0041268 promotes NSCLC progress by sponging miR-214-5p/ROCK1.	hsa_circ_0041268		hsa_circ_PRPF8	PRPF8	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0041268 is up-regulated in NSCLC cell lines and promotes proliferation, migration, tumor growth and metastasis. Mechanistically, it acts as a ceRNA by sponging miR-214-5p to increase ROCK1 expression (hsa_circ_0041268/miR-214-5p/ROCK1 axis)."	0.6261
35212603	Bioengineered	2022	The novel circular RNA HIPK3 accelerates the proliferation and invasion of hepatocellular carcinoma cells by sponging the micro RNA-124 or micro RNA-506/pyruvate dehydrogenase kinase 2 axis.	hsa_circ_0000284	circHIPK3 / circRNA HIPK3	hsa_circ_HIPK3	HIPK3	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in HCC tissues and cell lines and promotes HCC cell proliferation and invasion as well as xenograft tumor growth. It functions as a ceRNA by sponging miR-124 and miR-506, thereby upregulating the downstream target gene PDK2."	0.6966
35212606	Bioengineered	2022	Circular RNA mmu_circ_0001295 from hypoxia pretreated adipose-derived mesenchymal stem cells (ADSCs) exosomes improves outcomes and inhibits sepsis-induced renal injury in a mouse model of sepsis.	mmu_circ_0001295				sepsis-induced acute kidney injury	MONDO:0002492	acute kidney injury	down-regulated	RT-qPCR; RNA-seq	"mmu_circ_0001295 is enriched in exosomes from hypoxia-pretreated ADSCs and is reduced in plasma during CLP-induced sepsis. Exosomal delivery of mmu_circ_0001295 contributes to the protective effect of HExo in septic mice, improving survival and mitigating renal injury, vascular leakage, and systemic inflammation; the downstream mechanism was not resolved."	0.5491
35212610	Bioengineered	2022	"Circular RNA hsa_circ_0008896 accelerates atherosclerosis by promoting the proliferation, migration and invasion of vascular smooth muscle cells via hsa-miR-633/CDC20B (cell division cycle 20B) axis."	hsa_circ_0008896				atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"In ox-LDL_treated human VSMCs and a mouse femoral-artery wire-injury model, hsa_circ_0008896 is up-regulated and promotes VSMC proliferation, migration and invasion. Mechanistically, it acts as a ceRNA that sponges hsa-miR-633, thereby increasing CDC20B expression and accelerating atherosclerosis-related cellular behaviors."	0.6733
35212614	Bioengineered	2022	"Circular RNA midline-1 (circMID1) promotes proliferation, migration, invasion and glycolysis in prostate cancer."	hsa_circ_0007933		hsa_circ_MID1	MID1	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	"circMID1 (hsa_circ_0007933), derived from the MID1 gene, is up-regulated in prostate cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes proliferation, cell-cycle progression, migration, invasion and glycolysis and enhances xenograft tumor growth. Mechanistically, circMID1 sponges miR-330-3p to increase YTHDC2 and IGF1R expression, activating the IGF1R/AKT signaling axis."	0.8635
35212617	Bioengineered	2022	Circular RNA-microRNA-mRNA network identified circ_0007618 and circ_0029426 as new valuable biomarkers for lung adenocarcinoma.	hsa_circ_0007618		hsa_circ_DOCK5	DOCK5	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circ_0007618 is up-regulated in LUAD tissues, serum, and lung cancer cell lines, is mainly localized in the cytoplasm, and is proposed to act within a predicted ceRNA network by binding multiple miRNAs and regulating hub genes such as PIK3CA and NRAS. High circ_0007618 expression correlates with clinicopathological features and predicts poor overall survival, supporting its potential as a diagnostic/prognostic biomarker."	0.7329
35212617	Bioengineered	2022	Circular RNA-microRNA-mRNA network identified circ_0007618 and circ_0029426 as new valuable biomarkers for lung adenocarcinoma.	hsa_circ_0029426		hsa_circ_RAN	RAN	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; Microarray	"circ_0029426 is down-regulated in LUAD tissues, serum, and lung cancer cell lines, is mainly localized in the cytoplasm, and is proposed to act within a predicted ceRNA network by binding multiple miRNAs and regulating hub genes such as KRAS/ETS1 (and KARS in the PPI analysis). Despite being down-regulated, high circ_0029426 levels are associated with poor overall survival, and it shows diagnostic value by ROC analysis."	0.7329
35213267	Bioengineered	2022	Circular RNA circRNA_0067934 promotes glioma development by modulating the microRNA miR-7/ Wnt/beta-catenin axis.	hsa_circ_0067934				glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circRNA_0067934 is up-regulated in glioma tissues and promotes malignant phenotypes (proliferation, invasion, migration). Mechanistically, it sponges miR-7 and activates/modulates Wnt/beta-catenin signaling, increasing WNT1 and beta-catenin protein levels."	0.6261
35220395	Cell death & disease	2022	CircCYP24A1 hampered malignant phenotype of renal cancer carcinoma through modulating CMTM-4 expression via sponging miR-421.	hsa_circ_0060927		hsa_circ_CYP24A1	CYP24A1	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	down-regulated	RT-qPCR; ISH; RNA-seq	"circCYP24A1 (hsa_circ_0060927), derived from CYP24A1, is down-regulated in RCC tissues and cell lines and its low expression is associated with worse overall survival. Functionally, circCYP24A1 suppresses RCC proliferation, invasion, migration and metastasis and promotes apoptosis. Mechanistically, it acts as a ceRNA sponge for miR-421 to upregulate CMTM4, thereby dampening EMT- and MEK/ERK- and AKT/mTOR-related malignant phenotypes."	0.8793
35220397	Cell death & disease	2022	Circ-PKD2 promotes Atg13-mediated autophagy by inhibiting miR-646 to increase the sensitivity of cisplatin in oral squamous cell carcinomas.			hsa_circ_PKD2	PKD2	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"In OSCC cells under cisplatin treatment, circ-PKD2 enhances chemosensitivity by promoting autophagy and apoptosis. Mechanistically, circ-PKD2 sponges miR-646 to relieve repression of ATG13, leading to increased ATG13 and caspase-8/caspase-3 activation, and reduced xenograft tumor growth with cisplatin."	0.6542
35220907	Bioengineered	2022	Circular RNA Circ_0008043 promotes the proliferation and metastasis of hepatocellular carcinoma cells by regulating the microRNA (miR)-326/RAB21 axis.	hsa_circ_0008043				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0008043 is up-regulated in HCC tissues and cell lines and acts as an oncogenic circRNA. It promotes proliferation, migration/invasion and EMT by sponging miR-326 to increase RAB21, and its knockdown suppresses xenograft tumor growth. It also shows diagnostic potential by ROC analysis and correlates with aggressive clinicopathologic features."	0.8315
35220908	Bioengineered	2022	"Circular RNA Eps15-homology domain containing protein 2 motivates proliferation, glycolysis but refrains autophagy in non-small cell lung cancer via crosstalk with microRNA-3186-3p and forkhead box K1."			hsa_circ_EHD2	EHD2	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circEHD2 is up-regulated in NSCLC tissues/cells and acts oncogenically by promoting proliferation and glycolysis while inhibiting apoptosis and autophagy. Mechanistically, it sponges miR-3186-3p to increase FOXK1, and knockdown of circEHD2 suppresses xenograft tumor growth."	0.6278
35222519	Frontiers in genetics	2021	Integrated Analysis of the CircRNA-Based ceRNA Network in Renal Fibrosis Induced by Ischemia Reperfusion Injury.	mmu_circ_0000823	circSlc8a1	mmu_circ_Slc8a1	Slc8a1	renal fibrosis / RF	MONDO:0000494	renal fibrosis	down-regulated	RT-qPCR; RNA-seq	"circSlc8a1 (mmu_circ_0000823) is significantly downregulated in UIRI- and UUO-induced renal fibrosis in mice. The study¡¯s ceRNA network analysis suggests circSlc8a1 may sponge multiple miRNAs and influence downstream mRNAs enriched in metabolic pathways, implicating it in renal fibrosis pathogenesis."	0.6521
35222519	Frontiers in genetics	2021	Integrated Analysis of the CircRNA-Based ceRNA Network in Renal Fibrosis Induced by Ischemia Reperfusion Injury.	mmu_circ_0014064	circApoe	mmu_circ_Apoe	Apoe	renal fibrosis / RF	MONDO:0000494	renal fibrosis	up-regulated	RT-qPCR; RNA-seq	"circApoe (mmu_circ_0014064) is upregulated in mouse renal fibrosis models. Network analysis indicates it may act as a miRNA sponge and associate with downstream genes enriched in the cytokine_cytokine receptor pathway, suggesting involvement in fibrotic pathogenesis."	0.5922
35222519	Frontiers in genetics	2021	Integrated Analysis of the CircRNA-Based ceRNA Network in Renal Fibrosis Induced by Ischemia Reperfusion Injury.		circKcnt2	mmu_circ_Kcnt2	Kcnt2	renal fibrosis / RF	MONDO:0000494	renal fibrosis	up-regulated	RT-qPCR; RNA-seq	circKcnt2 was identified as upregulated in UIRI-induced fibrotic kidneys by RNA-seq and validated by RT-qPCR (also assessed in UUO validation). The study did not establish a specific mechanistic axis for circKcnt2 in renal fibrosis.	0.5618
35222519	Frontiers in genetics	2021	Integrated Analysis of the CircRNA-Based ceRNA Network in Renal Fibrosis Induced by Ischemia Reperfusion Injury.		circDcdc2 / circDcdc2a	mmu_circ_Dcdc2a	Dcdc2a	renal fibrosis / RF	MONDO:0000494	renal fibrosis	up-regulated	RT-qPCR; RNA-seq	circDcdc2/circDcdc2a was identified as upregulated in UIRI-induced renal fibrosis and validated by RT-qPCR; Sanger sequencing verified its back-splice junction. The study did not report a specific downstream miRNA/mRNA axis for this circRNA in renal fibrosis.	0.6262
35222519	Frontiers in genetics	2021	Integrated Analysis of the CircRNA-Based ceRNA Network in Renal Fibrosis Induced by Ischemia Reperfusion Injury.		circRftn1	mmu_circ_Rftn1	Rftn1	renal fibrosis / RF	MONDO:0000494	renal fibrosis	up-regulated	RT-qPCR; RNA-seq	circRftn1 was reported as upregulated in UIRI-induced renal fibrosis and its expression trend was validated by RT-qPCR. No specific mechanistic interactions or pathways were assigned to circRftn1 in this study.	0.5618
35222519	Frontiers in genetics	2021	Integrated Analysis of the CircRNA-Based ceRNA Network in Renal Fibrosis Induced by Ischemia Reperfusion Injury.		circCol1a2	mmu_circ_Col1a2	Col1a2	renal fibrosis / RF	MONDO:0000494	renal fibrosis	up-regulated	RT-qPCR; RNA-seq	circCol1a2 was identified as upregulated in UIRI-induced renal fibrosis and validated by RT-qPCR (also assessed in UUO validation). The paper did not report a defined mechanism or downstream regulatory axis for circCol1a2.	0.5618
35222519	Frontiers in genetics	2021	Integrated Analysis of the CircRNA-Based ceRNA Network in Renal Fibrosis Induced by Ischemia Reperfusion Injury.		circTinag	mmu_circ_Tinag	Tinag	renal fibrosis / RF	MONDO:0000494	renal fibrosis	down-regulated	RT-qPCR; RNA-seq	circTinag was identified as downregulated in UIRI-induced renal fibrosis and validated by RT-qPCR (also assessed in UUO validation). The study did not define a mechanistic axis for circTinag in renal fibrosis.	0.5618
35222519	Frontiers in genetics	2021	Integrated Analysis of the CircRNA-Based ceRNA Network in Renal Fibrosis Induced by Ischemia Reperfusion Injury.		circMettl9	mmu_circ_Mettl9	Mettl9	renal fibrosis / RF	MONDO:0000494	renal fibrosis	down-regulated	RT-qPCR; RNA-seq	circMettl9 was identified as downregulated in UIRI-induced renal fibrosis and validated by RT-qPCR; its back-splice junction was verified by Sanger sequencing. The study did not define a specific ceRNA axis or pathway for circMettl9 in renal fibrosis.	0.6262
35222519	Frontiers in genetics	2021	Integrated Analysis of the CircRNA-Based ceRNA Network in Renal Fibrosis Induced by Ischemia Reperfusion Injury.		circEgf	mmu_circ_Egf	Egf	renal fibrosis / RF	MONDO:0000494	renal fibrosis	down-regulated	RT-qPCR; RNA-seq	circEgf was identified as downregulated in UIRI-induced renal fibrosis and validated by RT-qPCR (also assessed in UUO validation). The study did not provide a specific mechanistic pathway for circEgf.	0.5618
35222721	Experimental and therapeutic medicine	2022	"Circular RNA, hsa_circRNA_102049, promotes colorectal cancer cell migration and invasion via binding and suppressing miRNA-455-3p."	hsa_circ_0043278	hsa_circRNA_102049	hsa_circ_TADA2A	TADA2A	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"hsa_circRNA_102049 (alias hsa_circ_0043278, host gene TADA2A) is upregulated in colorectal cancer tissues and cell lines. It promotes CRC proliferation, cell-cycle progression, migration and invasion and inhibits apoptosis by sponging/binding miR-455-3p, supported by luciferase and rescue experiments."	0.6542
35222740	Disease markers	2022	Exosomal hsa_circ_0008925 from Urine Is Related to Chronic Renal Fibrosis.	hsa_circ_0008925		hsa_circ_SEC63	sec63	renal fibrosis / RF	MONDO:0000494	renal fibrosis	up-regulated	RT-qPCR	"hsa_circ_0008925 is up-regulated in exosomes from TGF-beta1-treated HK-2 cells and in urinary exosomes from glomerular disease patients with renal fibrosis. Its urinary exosomal level correlates with renal function and fibrosis pathology scores and shows diagnostic value for renal fibrosis, but the molecular mechanism was not explored."	0.459
35222790	Oxidative medicine and cellular longevity	2022	Arterial Pulsatility Augments Microcirculatory Perfusion and Maintains the Endothelial Integrity during Extracorporeal Membrane Oxygenation via hsa_circ_0007367 Upregulation in a Canine Model with Cardiac Arrest.	hsa_circ_0007367	circUBAP2	hsa_circ_UBAP2	UBAP2	cardiac arrest	MONDO:0000745	cardiac arrest	up-regulated	RT-qPCR	"In a cardiac-arrest canine ECMO model and endothelial cells exposed to pulsatile flow, hsa_circ_0007367 (circUBAP2) is upregulated and is required to maintain endothelial barrier integrity. Its upregulation supports ZO-1/occludin expression and contributes to anti-inflammatory effects involving eNOS modulation and NF-kappaB inhibition, thereby improving microcirculatory perfusion during ECMO."	0.421
35223093	Cardiology research and practice	2022	Construction of a circRNA-miRNA-mRNA Regulatory Network for Coronary Artery Disease by Bioinformatics Analysis.	hsa_circ_0020275		hsa_circ_HTRA1	HTRA1	coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	up-regulated	Microarray	hsa_circ_0020275 is predicted (from CAD microarray data and in silico interaction analysis) to participate in CAD via a ceRNA network and potentially influence ubiquitin-mediated proteolysis through regulation of hub genes.	0.1768
35223093	Cardiology research and practice	2022	Construction of a circRNA-miRNA-mRNA Regulatory Network for Coronary Artery Disease by Bioinformatics Analysis.	hsa_circ_0020387		hsa_circ_DOCK1	DOCK1	coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	up-regulated	Microarray	hsa_circ_0020387 is predicted (from CAD microarray data and in silico interaction analysis) to participate in CAD via a ceRNA network and potentially influence ubiquitin-mediated proteolysis through regulation of hub genes.	0.1768
35223093	Cardiology research and practice	2022	Construction of a circRNA-miRNA-mRNA Regulatory Network for Coronary Artery Disease by Bioinformatics Analysis.	hsa_circ_0020417		hsa_circ_DOCK1	DOCK1	coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	up-regulated	Microarray	hsa_circ_0020417 is predicted (from CAD microarray data and in silico interaction analysis) to participate in CAD via a ceRNA network and potentially influence ubiquitin-mediated proteolysis through regulation of hub genes.	0.1768
35223093	Cardiology research and practice	2022	Construction of a circRNA-miRNA-mRNA Regulatory Network for Coronary Artery Disease by Bioinformatics Analysis.	hsa_circ_0045512		hsa_circ_ABCA9	ABCA9	coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	up-regulated	Microarray	hsa_circ_0045512 is predicted (from CAD microarray data and in silico interaction analysis) to participate in CAD via a ceRNA network and potentially influence ubiquitin-mediated proteolysis through regulation of hub genes.	0.1768
35223093	Cardiology research and practice	2022	Construction of a circRNA-miRNA-mRNA Regulatory Network for Coronary Artery Disease by Bioinformatics Analysis.	hsa_circ_0047336		hsa_circ_DSC2	DSC2	coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	up-regulated	Microarray	hsa_circ_0047336 is predicted (from CAD microarray data and in silico interaction analysis) to participate in CAD via a ceRNA network and potentially influence ubiquitin-mediated proteolysis through regulation of hub genes.	0.1768
35223093	Cardiology research and practice	2022	Construction of a circRNA-miRNA-mRNA Regulatory Network for Coronary Artery Disease by Bioinformatics Analysis.	hsa_circ_0069094		hsa_circ_S100P	S100P	coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	up-regulated	Microarray	hsa_circ_0069094 is predicted (from CAD microarray data and in silico interaction analysis) to participate in CAD via a ceRNA network and potentially influence ubiquitin-mediated proteolysis through regulation of hub genes.	0.1768
35223093	Cardiology research and practice	2022	Construction of a circRNA-miRNA-mRNA Regulatory Network for Coronary Artery Disease by Bioinformatics Analysis.	hsa_circ_0071326		hsa_circ_FAM198B	FAM198B	coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	up-regulated	Microarray	hsa_circ_0071326 is predicted (from CAD microarray data and in silico interaction analysis) to participate in CAD via a ceRNA network and potentially influence ubiquitin-mediated proteolysis through regulation of hub genes.	0.1768
35223093	Cardiology research and practice	2022	Construction of a circRNA-miRNA-mRNA Regulatory Network for Coronary Artery Disease by Bioinformatics Analysis.	hsa_circ_0071330		hsa_circ_TMEM144	TMEM144	coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	up-regulated	Microarray	hsa_circ_0071330 is predicted (from CAD microarray data and in silico interaction analysis) to participate in CAD via a ceRNA network and potentially influence ubiquitin-mediated proteolysis through regulation of hub genes.	0.1768
35223093	Cardiology research and practice	2022	Construction of a circRNA-miRNA-mRNA Regulatory Network for Coronary Artery Disease by Bioinformatics Analysis.	hsa_circ_0085340		hsa_circ_CSMD3	CSMD3	coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	up-regulated	Microarray	hsa_circ_0085340 is predicted (from CAD microarray data and in silico interaction analysis) to participate in CAD via a ceRNA network and potentially influence ubiquitin-mediated proteolysis through regulation of hub genes.	0.1768
35225027	Cell transplantation	2022	Evaluating the Effect of Circ-Sirt1 on the Expression of SIRT1 and Its Role in Pathology of Pulmonary Hypertension.		circ-Sirt1	rno_circ_SIRT1	SIRT1	pulmonary arterial hypertension / PAH	MONDO:0015924	pulmonary arterial hypertension	down-regulated	RT-qPCR	"In hypoxia-induced rat PAH, circ-Sirt1 is down-regulated. Restoring circ-Sirt1 increases SIRT1 expression and suppresses TGF-beta1/Smad3/Smad7 signaling, leading to reduced PASMC proliferation and migration and alleviation of pulmonary vascular remodeling in vivo."	0.4249
35225755	Bosnian journal of basic medical sciences	2022	Circular RNA circ_0020014 contributes to osteoarthritis progression via miR-613/ADAMTS5 axis.	hsa_circ_0020014	circ_0020014	hsa_circ_DUSP5	DUSP5	osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circ_0020014 is up-regulated in OA cartilage and IL-1beta-treated human chondrocytes. It mainly localizes to the cytoplasm and acts as a sponge for miR-613, thereby de-repressing ADAMTS5 and promoting inflammatory injury, apoptosis, and ECM degradation in chondrocytes; knockdown of circ_0020014 is protective."	0.7507
35227262	Molecular cancer	2022	Splicing factor derived circular RNA circCAMSAP1 accelerates nasopharyngeal carcinoma tumorigenesis via a SERPINH1/c-Myc positive feedback loop.	hsa_circ_0001900	circCAMSAP1	hsa_circ_CAMSAP1	CAMSAP1	nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circCAMSAP1 is up-regulated in nasopharyngeal carcinoma and promotes proliferation and metastasis. Mechanistically, circCAMSAP1 binds the SERPINH1 mRNA 3¡¯UTR to enhance SERPINH1 mRNA stability and expression; SERPINH1 then stabilizes c-Myc by inhibiting its ubiquitination-degradation, while c-Myc (with SRSF10) further increases circCAMSAP1 biogenesis, forming a positive feedback loop."	0.8489
35229026	Molecular therapy oncolytics	2022	Exosomal circSHKBP1 participates in non-small cell lung cancer progression through PKM2-mediated glycolysis.	hsa_circ_0000936	circSHKBP1 / circ-SHKBP1	hsa_circ_SHKBP1	SHKBP1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circSHKBP1 (hsa_circ_0000936), enriched in NSCLC-derived exosomes, is upregulated in NSCLC and promotes proliferation, migration/invasion, stemness, glycolysis, and in vivo tumor growth/metastasis. Mechanistically, it sponges miR-1294 to upregulate PKM2 and activate PKM2/HIF-1alpha-dependent glycolysis, fostering M2 macrophage polarization/recruitment and suppressing CD8+ T-cell cytokine secretion. Serum exosomal circSHKBP1 shows potential diagnostic value and correlates with advanced disease features and poor prognosis."	0.8818
35229272	Neurochemical research	2022	CircAXL Knockdown Alleviates Abeta1-42-Induced Neurotoxicity in Alzheimer's Disease via Repressing PDE4A by Releasing miR-1306-5p.	hsa_circ_0002945	circAXL / circ_0002945	hsa_circ_AXL	AXL	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR	"In an Abeta1-42-induced AD cellular model, circAXL is up-regulated and promotes neuronal injury phenotypes (reduced viability, increased apoptosis, inflammation, oxidative and ER stress). Mechanistically, circAXL sponges miR-1306-5p to derepress PDE4A. Serum exosomal circAXL is elevated in AD patients and shows diagnostic potential by ROC analysis."	0.8314
35229760	Asian journal of andrology	2022	Identification and characterization of circular RNAs in the testicular tissue of patients with non-obstructive azoospermia.	hsa_circ_0137890				non-obstructive azoospermia / NOA	MONDO:0100459	azoospermia	down-regulated	RT-qPCR; Microarray	hsa_circ_0137890 is significantly down-regulated in testicular tissue from NOA patients versus controls and is mainly localized in the cytoplasm. The study predicts it may interact with let-7 family miRNAs as part of miRNA-mediated (ceRNA-like) regulation and suggests it could be a potential biomarker for NOA.	0.6362
35229760	Asian journal of andrology	2022	Identification and characterization of circular RNAs in the testicular tissue of patients with non-obstructive azoospermia.	hsa_circ_0136298				non-obstructive azoospermia / NOA	MONDO:0100459	azoospermia	down-regulated	RT-qPCR; Microarray	"hsa_circ_0136298 is significantly down-regulated in NOA testicular tissue and is mainly localized in the cytoplasm. Bioinformatic prediction suggests it can bind miR-221 and miR-762, potentially participating in miRNA-mediated regulation (including KIT-related regulation via miR-221). It is proposed as a potential biomarker for NOA."	0.6362
35229760	Asian journal of andrology	2022	Identification and characterization of circular RNAs in the testicular tissue of patients with non-obstructive azoospermia.	hsa_circ_0007273				non-obstructive azoospermia / NOA	MONDO:0100459	azoospermia	down-regulated	RT-qPCR; Microarray	"hsa_circ_0007273 is significantly down-regulated in testicular tissue from NOA patients and is predominantly cytoplasmic. The study predicts it may bind miR-762, supporting a potential role in miRNA-mediated regulation, and proposes it as a potential biomarker candidate for NOA."	0.6362
35230201	Bioengineered	2022	CircPTK2 inhibits cell cisplatin (CDDP) resistance by targeting miR-942/TRIM16 axis in non-small cell lung cancer (NSCLC).	hsa_circ_0008305	CircPTK2	hsa_circ_PTK2	PTK2	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"circPTK2 (hsa_circ_0008305) is down-regulated in NSCLC tissues/cell lines and further decreased in CDDP-resistant NSCLC cells. circPTK2 mainly localizes to the cytoplasm and functions as a miR-942 sponge to derepress TRIM16, thereby suppressing proliferation/migration/invasion and glycolysis, promoting apoptosis, and reducing cisplatin resistance in vitro and in a xenograft model."	0.7735
35233376	Journal of clinical and translational hepatology	2022	Detection of Prognostic Biomarkers for Hepatocellular Carcinoma through CircRNA-associated CeRNA Analysis.	hsa_circ_0004662				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	dysregulated	RT-qPCR; RNA-seq; Microarray	hsa_circ_0004662 was identified as a differentially expressed hub circRNA in an HCC ceRNA network. Its role was proposed through bioinformatic ceRNA modeling and supported by RT-qPCR validation in paired tumor and paracancerous tissues.	0.4297
35233376	Journal of clinical and translational hepatology	2022	Detection of Prognostic Biomarkers for Hepatocellular Carcinoma through CircRNA-associated CeRNA Analysis.	hsa_circ_0005735				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	dysregulated	RT-qPCR; RNA-seq; Microarray	hsa_circ_0005735 was identified as a differentially expressed hub circRNA in an HCC ceRNA network and was experimentally validated as differentially expressed between tumor and paracancerous tissues by RT-qPCR.	0.4297
35233376	Journal of clinical and translational hepatology	2022	Detection of Prognostic Biomarkers for Hepatocellular Carcinoma through CircRNA-associated CeRNA Analysis.	hsa_circ_0006990				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	dysregulated	RT-qPCR; RNA-seq; Microarray	"hsa_circ_0006990 was highlighted as a hub circRNA in an HCC ceRNA network and was validated as differentially expressed between HCC tumors and paracancerous tissues, suggesting involvement in HCC progression."	0.4297
35233376	Journal of clinical and translational hepatology	2022	Detection of Prognostic Biomarkers for Hepatocellular Carcinoma through CircRNA-associated CeRNA Analysis.	hsa_circ_0018403				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	dysregulated	RT-qPCR; RNA-seq; Microarray	"hsa_circ_0018403 was identified as a differentially expressed hub circRNA in an HCC ceRNA network and validated by RT-qPCR in paired clinical tissues, indicating potential involvement in HCC development."	0.4297
35233376	Journal of clinical and translational hepatology	2022	Detection of Prognostic Biomarkers for Hepatocellular Carcinoma through CircRNA-associated CeRNA Analysis.	hsa_circ_0100609				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	dysregulated	RT-qPCR; RNA-seq; Microarray	"hsa_circ_0100609 was identified as a hub circRNA in an HCC ceRNA network and was validated as differentially expressed in HCC tumors versus paracancerous tissues, supporting its potential relevance to HCC progression and prognosis modeling."	0.4297
35233464	"Open medicine (Warsaw, Poland)"	2022	circ_AKT3 knockdown suppresses cisplatin resistance in gastric cancer.		circ_AKT3	hsa_circ_AKT3	AKT3	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_AKT3 is up-regulated in cisplatin-resistant gastric cancer tissues and resistant cell lines. Functionally, circ_AKT3 promotes cisplatin resistance (higher IC50 and P-gp, lower apoptosis) and enhances tumor growth in a cell line-derived xenograft model by sponging miR-206 to upregulate PTPN14 (ceRNA axis)."	0.7032
35233964	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2022	circREEP3 Drives Colorectal Cancer Progression via Activation of FKBP10 Transcription and Restriction of Antitumor Immunity.		circREEP3 / hsa_circRNA_400564	hsa_circ_REEP3	REEP3	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Northern Blot; ISH; Microarray	"circREEP3 is up-regulated in colorectal cancer and its high expression predicts poor survival. Functionally, it promotes CRC proliferation, invasion/metastasis and stemness. Mechanistically, circREEP3 activates FKBP10 transcription by recruiting CHD7 to the FKBP10 promoter and suppresses RIG-1-dependent antitumor immunity by enhancing RNF125-mediated RIG-1 degradation."	0.8998
35235752	Bioengineered	2022	Circular RNA F-circEA-2a expression is increased in gastric adenocarcinoma and inhibits the transition from premature microRNA-3940-5p to mature microRNA-3940-5p.		F-circEA-2a			gastric adenocarcinoma / GA	MONDO:0005036	gastric adenocarcinoma	up-regulated	RT-qPCR	"F-circEA-2a is up-regulated in gastric adenocarcinoma tissues and promotes GA cell proliferation. Mechanistically, it directly binds (sponges) premature miR-3940-5p, inhibiting its maturation and thereby weakening the anti-proliferative effect of miR-3940-5p."	0.6524
35236250	Bioengineered	2022	Circular RNA ZNF609 promotes laryngeal squamous cell carcinoma progression by upregulating epidermal growth factor receptor via sponging microRNA-134-5p.		CircZNF609 / circRNA ZNF609 	hsa_circ_ZNF609	ZNF609	laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR	"circZNF609 is up-regulated in LSCC and promotes proliferation and invasion. Mechanistically, it functions as a ceRNA by sponging miR-134-5p, thereby increasing EGFR expression, and its high expression is associated with poor overall survival."	0.7412
35236349	Molecular cancer	2022	Characterization of distinct circular RNA signatures in solid tumors.	hsa_circ_0072309	circLIFR	hsa_circ_LIFR	LIFR	neoplasm	MONDO:0005070	neoplasm	down-regulated	RT-qPCR; RNA-seq	"circLIFR (hsa_circ_0072309), derived from LIFR, is down-regulated in six solid tumors (LUAD, ESCC, CRC, GC, HCC, THCA). Functional assays show circLIFR suppresses cancer cell migration in vitro and metastasis in vivo, and transcriptome analyses suggest it modulates cell adhesion and EMT-related gene programs."	0.7159
35236829	Cell death discovery	2022	EIF4A3-mediated circPRKCI expression promotes triple-negative breast cancer progression by regulating WBP2 and PI3K/AKT signaling pathway.	hsa_circ_0067934	circPRKCI / circ_0067934	hsa_circ_PRKCI	PRKCI	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"circPRKCI (hsa_circ_0067934), derived from PRKCI, is up-regulated in TNBC tissues and cell lines and promotes TNBC proliferation, migration, and xenograft tumor growth. Mechanistically, circPRKCI acts as a miR-545-3p sponge to increase WBP2 and enhance AKT phosphorylation, activating PI3K/AKT signaling; EIF4A3 promotes circPRKCI expression and nuclear export."	0.8532
35237504	Frontiers in oncology	2022	SP1-Mediated Upregulation of circFAM126A Promotes Proliferation and Epithelial-Mesenchymal Transition of Oral Squamous Cell Carcinoma via Regulation of RAB41.	hsa_circ_0001682	circFAM126A / circ_0001682	hsa_circ_FAM126A	FAM126A	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circFAM126A is upregulated in OSCC and acts as an oncogenic circRNA that promotes proliferation, invasion/migration and EMT, as well as tumor growth and metastasis in vivo. Mechanistically, it is transcriptionally activated by SP1 and promotes RAB41 expression through sponging miR-186 and interacting with the RBP FUS to enhance RAB41 mRNA stability (miR-186/FUS/RAB41 axis). High circFAM126A is associated with poor overall survival."	0.8793
35239998	EMBO reports	2022	Dysregulation of the miR-30c/DLL4 axis by circHIPK3 is essential for KSHV lytic replication.	hsa_circ_0000284	circHIPK3	hsa_circ_HIPK3	HIPK3	Kaposi¡¯s sarcoma	MONDO:0005055	Kaposi's sarcoma	up-regulated	RT-qPCR	"During KSHV lytic replication in B cells, circHIPK3 is up-regulated and mainly localized in the cytoplasm. It acts as a ceRNA/miRNA sponge for miR-30c (and miR-29b), resulting in increased DLL4 expression and promoting cell-cycle changes that support efficient viral lytic replication and infectious virion production."	0.6634
35241028	BMC cancer	2022	Circular RNA hsa_circ_0000277 promotes tumor progression and DDP resistance in esophageal squamous cell carcinoma.	hsa_circ_0000277	circ_0000277	hsa_circ_PDE3B	PDE3B	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"hsa_circ_0000277 is up-regulated in ESCC tissues and cell lines and promotes proliferation/tumor growth and cisplatin (DDP) resistance. Mechanistically, it sponges miR-873-5p to upregulate SOX4 and activate Wnt/beta-catenin signaling, thereby enhancing malignant progression and chemoresistance."	0.8729
35242035	Frontiers in pharmacology	2022	Tumor-Derived circRNAs as Circulating Biomarkers for Breast Cancer.	hsa_circ_0000091				breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	hsa_circ_0000091 is down-regulated in breast cancer patient plasma and is part of a 3-circRNA diagnostic model with high AUC. Lower plasma hsa_circ_0000091 is associated with metastasis-related features and poorer patient prognosis; mechanistically it is predicted (not experimentally validated) to act via miRNA sponging and cancer-related pathways.	0.5534
35242035	Frontiers in pharmacology	2022	Tumor-Derived circRNAs as Circulating Biomarkers for Breast Cancer.	hsa_circ_0067772				breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0067772 is up-regulated in breast cancer patient plasma and, together with two other circRNAs, contributes to a high-performing diagnostic model. Its downstream role is only computationally inferred via predicted miRNA sponging and pathway enrichment."	0.5534
35242035	Frontiers in pharmacology	2022	Tumor-Derived circRNAs as Circulating Biomarkers for Breast Cancer.	hsa_circ_0000512				breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	hsa_circ_0000512 is up-regulated in breast cancer patient plasma and is used together with two other circRNAs to build and validate a diagnostic model. Its mechanistic role is only predicted via miRNA-sponging bioinformatics and pathway enrichment.	0.5534
35242648	Translational pediatrics	2022	Systematic screen of potential circular RNA biomarkers of Hirschsprung's disease.		hsa_circRNA_092493			Hirschsprung¡¯s disease / HSCR	MONDO:0018309	Hirschsprung disease	up-regulated	RT-qPCR; Microarray	hsa_circRNA_092493 is up-regulated in HSCR intestinal/megacolon tissue and may function as a ceRNA by sponging miRNAs to de-repress target mRNAs. It also shows potential diagnostic value based on ROC/AUC analysis.	0.5047
35242648	Translational pediatrics	2022	Systematic screen of potential circular RNA biomarkers of Hirschsprung's disease.		hsa_circRNA_101965			Hirschsprung¡¯s disease / HSCR	MONDO:0018309	Hirschsprung disease	up-regulated	RT-qPCR; Microarray	hsa_circRNA_101965 is robustly up-regulated in HSCR tissue and is proposed to act as a miRNA sponge within a circRNA-miRNA-mRNA network. It shows diagnostic potential for HSCR (AUC reported).	0.5047
35242648	Translational pediatrics	2022	Systematic screen of potential circular RNA biomarkers of Hirschsprung's disease.		hsa_circRNA_103118			Hirschsprung¡¯s disease / HSCR	MONDO:0018309	Hirschsprung disease	up-regulated	RT-qPCR; Microarray	hsa_circRNA_103118 is up-regulated in HSCR tissue and is implicated as a ceRNA that sponges miRNAs to release repression of target mRNAs. It may serve as a diagnostic biomarker (AUC reported).	0.5047
35242648	Translational pediatrics	2022	Systematic screen of potential circular RNA biomarkers of Hirschsprung's disease.		hsa_circRNA_103279			Hirschsprung¡¯s disease / HSCR	MONDO:0018309	Hirschsprung disease	up-regulated	RT-qPCR; Microarray	hsa_circRNA_103279 is significantly up-regulated in HSCR tissue and is proposed to participate in HSCR through a circRNA-miRNA-mRNA sponge network. It has reported diagnostic capability based on ROC/AUC.	0.5047
35242648	Translational pediatrics	2022	Systematic screen of potential circular RNA biomarkers of Hirschsprung's disease.		hsa_circRNA_104214			Hirschsprung¡¯s disease / HSCR	MONDO:0018309	Hirschsprung disease	up-regulated	RT-qPCR; Microarray	hsa_circRNA_104214 is up-regulated in HSCR tissue and is suggested to function through a circRNA-miRNA-mRNA ceRNA network (miRNA sponge effect). It also shows diagnostic potential based on ROC/AUC analysis.	0.5047
35242856	Annals of translational medicine	2022	CircRASSF2 promotes IGF1R and osteosarcoma metastasis via sponging miR-6838-5p.		circRASSF2	hsa_circ_RASSF2	RASSF2	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circRASSF2 is up-regulated in osteosarcoma cells and tissues and promotes proliferation, migration/invasion and metastasis-related behaviors. Mechanistically, it acts as a ceRNA to sponge miR-6838-5p, restoring IGF1R expression and activating downstream PI3K/AKT signaling. Clinically, higher circRASSF2 levels are associated with advanced stage and distant metastasis."	0.7164
35246018	Bioengineered	2022	Circular RNA hsa_circ_0077837 is upregulated in non-small cell lung cancer to downregulate phosphatase and tensin homolog through methylation.	hsa_circ_0077837				non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0077837 is upregulated in NSCLC tissues and is associated with worse patient survival. In HCC827 cells, hsa_circ_0077837 overexpression increases PTEN gene methylation and reduces PTEN expression, thereby suppressing apoptosis; PTEN overexpression counteracts this effect."	0.7328
35246267	Acta neuropathologica communications	2022	Circular RNA detection identifies circPSEN1 alterations in brain specific to autosomal dominant Alzheimer's disease.		circPSEN1 / Circular PSEN1	hsa_circ_PSEN1	PSEN1	autosomal dominant Alzheimer's disease / ADAD	MONDO:0015140	early-onset autosomal dominant Alzheimer disease	up-regulated	RNA-seq	"circPSEN1 is up-regulated in ADAD brains compared with sporadic AD and controls based on bulk RNA-seq circRNA detection. In-silico analyses predict miRNA targeting and implicate pathways including Hippo and Wnt signaling and axon guidance, with potential relevance to neuroinflammation; circPSEN1 counts also show discriminatory ability for ADAD vs AD/controls."	0.348
35246267	Acta neuropathologica communications	2022	Circular RNA detection identifies circPSEN1 alterations in brain specific to autosomal dominant Alzheimer's disease.	hsa_circ_0008521		hsa_circ_PSEN1	PSEN1	autosomal dominant Alzheimer's disease / ADAD	MONDO:0015140	early-onset autosomal dominant Alzheimer disease	up-regulated	RNA-seq	"hsa_circ_0008521 is one of the most abundant circPSEN1 species and is significantly higher in ADAD than in sporadic AD and controls, contributing to the overall circPSEN1 up-regulation signal."	0.2995
35246267	Acta neuropathologica communications	2022	Circular RNA detection identifies circPSEN1 alterations in brain specific to autosomal dominant Alzheimer's disease.	hsa_circ_0003848		hsa_circ_PSEN1	PSEN1	autosomal dominant Alzheimer's disease / ADAD	MONDO:0015140	early-onset autosomal dominant Alzheimer disease	up-regulated	RNA-seq	"hsa_circ_0003848 is a predominant circPSEN1 species and is significantly increased in ADAD compared with sporadic AD and controls, contributing to the overall circPSEN1 elevation observed in ADAD."	0.2995
35246267	Acta neuropathologica communications	2022	Circular RNA detection identifies circPSEN1 alterations in brain specific to autosomal dominant Alzheimer's disease.	hsa_circ_0002564		hsa_circ_PSEN1	PSEN1	autosomal dominant Alzheimer's disease / ADAD	MONDO:0015140	early-onset autosomal dominant Alzheimer disease	up-regulated	RNA-seq	"hsa_circ_0002564 is an abundant circPSEN1 species with significantly higher levels in ADAD vs sporadic AD and controls; the paper notes a PSEN1 mutation (p.H163R) lies at its boundaries as a possible contributor, though not sufficient to explain the overall association."	0.1155
35246505	Cell death & disease	2022	The mmu_circRNA_37492/hsa_circ_0012138 function as potential ceRNA to attenuate obstructive renal fibrosis.		circRNA_37492 / mmu_circRNA_37492	mmu_circ_Eri3	Eri3	obstructive renal fibrosis	MONDO:0056796	obstructive nephropathy	up-regulated	RT-qPCR; ISH; Microarray	"In UUO/TGF-beta1-induced renal fibrosis models, circRNA_37492 is up-regulated and mainly localized in the cytoplasm. It attenuates fibrosis by sponging miR-7682-3p to increase the antifibrotic target Fgb, reducing collagen I/III and fibronectin deposition."	0.692
35246505	Cell death & disease	2022	The mmu_circRNA_37492/hsa_circ_0012138 function as potential ceRNA to attenuate obstructive renal fibrosis.	hsa_circ_0012138	hsa_circRNA_0012138	hsa_circ_ERI3	ERI3	obstructive nephropathy	MONDO:0056796	obstructive nephropathy	up-regulated	RT-qPCR	"In human obstructive hydronephrosis kidney cortex, hsa_circ_0012138 is up-regulated and correlates with obstruction severity. The study proposes it may act as a ceRNA (potentially via miR-651-5p/FGB and other miRNAs), but direct binding/axis validation was not performed."	0.4535
35251136	Frontiers in genetics	2022	Involvement of CircRNA Expression Profile in Diabetic Retinopathy and Its Potential Diagnostic Value.	hsa_circ_0095008		hsa_circ_NCAM2	NCAM2	diabetic retinopathy / DR	MONDO:0005266	diabetic retinopathy	down-regulated	RT-qPCR; Microarray	"hsa_circ_0095008 is down-regulated in PBMCs from DR patients versus DM patients and healthy controls, validated by microarray and RT-qPCR. It may act as a miRNA sponge based on bioinformatic prediction and shows diagnostic potential for DR by ROC analysis."	0.5047
35251136	Frontiers in genetics	2022	Involvement of CircRNA Expression Profile in Diabetic Retinopathy and Its Potential Diagnostic Value.	hsa_circ_0001883		hsa_circ_ORM1	ORM1	diabetic retinopathy / DR	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001883 is up-regulated in PBMCs from DR patients versus DM patients and healthy controls, validated by microarray and RT-qPCR. It is predicted to bind many miRNAs (miRanda-based network) and shows potential diagnostic value for DR in ROC analysis."	0.5047
35251136	Frontiers in genetics	2022	Involvement of CircRNA Expression Profile in Diabetic Retinopathy and Its Potential Diagnostic Value.	hsa_circ_0040707				diabetic retinopathy / DR	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR; Microarray	"hsa_circ_0040707 is increased in PBMCs of DR patients compared with healthy controls, based on RT-qPCR validation of microarray-selected candidates. No mechanism or clinical utility was further established in this study."	0.3588
35251136	Frontiers in genetics	2022	Involvement of CircRNA Expression Profile in Diabetic Retinopathy and Its Potential Diagnostic Value.	hsa_circ_0005062				diabetic retinopathy / DR	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR; Microarray	hsa_circ_0005062 shows higher expression in PBMCs from DR patients compared with DM patients in the RT-qPCR validation cohort. The study did not further define its mechanism or clinical diagnostic value.	0.3588
35251305	Cardiovascular therapeutics	2022	CircTRRAP Knockdown Has Cardioprotective Function in Cardiomyocytes via the Signal Regulation of miR-370-3p/PAWR Axis.	hsa_circ_0081241	circTRRAP / Circular RNA Transformation	hsa_circ_TRRAP	TRRAP	acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR	"circTRRAP is up-regulated under hypoxia and promotes hypoxia-induced cardiomyocyte injury. Mechanistically, it sponges miR-370-3p to relieve repression of PAWR, thereby enhancing apoptosis, inflammation and oxidative stress; circTRRAP knockdown is cardioprotective in AC16 cells."	0.7256
35252169	Frontiers in cell and developmental biology	2022	Circular RNA circ0007360 Attenuates Gastric Cancer Progression by Altering the miR-762/IRF7 Axis.		circ0007360 / circ4779	hsa_circ_ATF6	ATF6	gastric cancer / GC	MONDO:0001056	gastric cancer	unknown	RT-qPCR; ISH	"circ0007360 acts as a cytoplasmic tumor-suppressive circRNA in gastric cancer models. It sponges miR-762 to indirectly upregulate IRF7, thereby inhibiting proliferation/survival, migration, invasion, and stemness while promoting apoptosis; knockdown enhances tumor growth in xenografts."	0.8004
35252820	iScience	2022	Changes in transcriptomic landscape in human end-stage heart failure with distinct etiology.		hsa-BAALC_0012	hsa_circ_BAALC	BAALC	heart failure / HF	MONDO:0005252	heart failure	up-regulated	RNA-seq	hsa-BAALC_0012 is up-regulated in end-stage HF and highlighted as a key circRNA with many predicted RNA-binding protein interactions within HF regulatory networks. Its HF-related role is supported by circRNA-seq differential expression and bioinformatic interaction predictions (no RT-qPCR validation reported).	0.3528
35252820	iScience	2022	Changes in transcriptomic landscape in human end-stage heart failure with distinct etiology.		hsa-STC2_0003	hsa_circ_STC2	STC2	heart failure / HF	MONDO:0005252	heart failure	up-regulated	RNA-seq	"hsa-STC2_0003 is up-regulated in end-stage HF and is highlighted as a circRNA predicted to interact with multiple RNA-binding proteins. Evidence is based on circRNA-seq differential expression and bioinformatic predictions, without reported RT-qPCR validation."	0.3528
35252820	iScience	2022	Changes in transcriptomic landscape in human end-stage heart failure with distinct etiology.		hsa-VEGFC_0030	hsa_circ_VEGFC	VEGFC	heart failure / HF	MONDO:0005252	heart failure	up-regulated	RNA-seq	"hsa-VEGFC_0030 is up-regulated in end-stage HF and is emphasized as a circRNA with many predicted RNA-binding protein interactions in HF networks. Support comes from circRNA-seq differential expression and bioinformatic prediction analyses, without experimental validation such as RT-qPCR."	0.3528
35252820	iScience	2022	Changes in transcriptomic landscape in human end-stage heart failure with distinct etiology.		hsa-F13A1_0031	hsa_circ_F13A1	F13A1	heart failure / HF	MONDO:0005252	heart failure	down-regulated	RNA-seq	"hsa-F13A1_0031 is down-regulated in end-stage HF and is highlighted as a circRNA with many predicted RNA-binding protein interactions. Evidence relies on circRNA-seq differential expression and bioinformatic predictions, without direct experimental validation such as RT-qPCR."	0.3528
35255963	Cell & bioscience	2022	Decoding ceRNA regulatory network in the pulmonary artery of hypoxia-induced pulmonary hypertension (HPH) rat model.	rno_circ_0001188	circ_0001188			hypoxia-induced pulmonary hypertension / HPH	MONDO:0017157	pulmonary hypertension owing to lung disease and/or hypoxia	down-regulated	RT-qPCR; RNA-seq	"circ_0001188 is down-regulated in pulmonary arteries of hypoxia-induced pulmonary hypertension rats. It is included in a predicted ceRNA network and may sponge rno-miR-127-3p and rno-miR-199a-5p to influence downstream target genes, though its functions require further validation."	0.4997
35255963	Cell & bioscience	2022	Decoding ceRNA regulatory network in the pulmonary artery of hypoxia-induced pulmonary hypertension (HPH) rat model.	rno_circ_0004345	circ_0004345			hypoxia-induced pulmonary hypertension / HPH	MONDO:0017157	pulmonary hypertension owing to lung disease and/or hypoxia	down-regulated	RT-qPCR; RNA-seq	"circ_0004345 is down-regulated in pulmonary arteries of hypoxia-induced pulmonary hypertension rats. It is part of a predicted ceRNA network and may sponge rno-miR-205 and rno-miR-541-5p to affect downstream genes, but mechanistic roles remain to be clarified."	0.4997
35255963	Cell & bioscience	2022	Decoding ceRNA regulatory network in the pulmonary artery of hypoxia-induced pulmonary hypertension (HPH) rat model.	rno_circ_0002500	circ_0002500			hypoxia-induced pulmonary hypertension / HPH	MONDO:0017157	pulmonary hypertension owing to lung disease and/or hypoxia	down-regulated	RT-qPCR; RNA-seq	"circ_0002500 is down-regulated in pulmonary arteries of HPH rats and is included as a predicted miRNA sponge for rno-miR-34c-5p within the ceRNA network, potentially influencing downstream mRNAs such as Scd, Ltbp2, Clic5, Cyyr1 and Sec14l4."	0.4997
35258395	Bioengineered	2022	Has_circ_0008583 modulates hepatocellular carcinoma progression through the miR-1301-3p/METTL3 pathway.	hsa_circ_0008583	hsa_circ_0008583			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"hsa_circ_0008583 is up-regulated in hepatocellular carcinoma tissues and cell lines. Functionally, it promotes HCC cell proliferation, migration and invasion and inhibits apoptosis, and its depletion suppresses xenograft tumor growth. Mechanistically, it acts as a ceRNA by sponging miR-1301-3p to relieve repression of METTL3 (hsa_circ_0008583/miR-1301-3p/METTL3 axis)."	0.6521
35258403	Bioengineered	2022	Identification of a novel circular RNA circZNF652/miR-486-5p/SERPINE1 signaling cascade that regulates cancer aggressiveness in glioblastoma (GBM).		circZNF652 / circ-ZNF652	hsa_circ_ZNF652	ZNF652	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR	"circZNF652 is upregulated in glioblastoma and promotes malignant phenotypes (proliferation, migration, invasion, EMT and tumorigenesis). Mechanistically, it functions as a ceRNA that sponges miR-486-5p to increase SERPINE1 expression, and high circZNF652 correlates with poor patient survival."	0.8595
35259044	Bioengineered	2022	Circular RNA hsa_circ_0011324 is involved in endometrial cancer progression and the evolution of its mechanism.	hsa_circ_0011324		hsa_circ_SPOCD1	SPOCD1	endometrial cancer / EC	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR	"In endometrial cancer, hsa_circ_0011324 is up-regulated and mainly localized in the cytoplasm. It promotes proliferation, migration, and invasion by acting as a ceRNA that sponges hsa-miR-497-5p and hsa-miR-16-5p, thereby increasing mTOR expression. High hsa_circ_0011324 expression is associated with poor OS and DFS."	0.8487
35260047	Bioengineered	2022	Circular RNA circ SET domain containing 2 (circSETD2) inhibits hepatocellular carcinoma cell proliferation and invasion in vivo and in vitro.	hsa_circ_0065173	circSETD2 / circular RNA circ SET domain containing 2 (circSETD2)	hsa_circ_SETD2	SETD2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"circSETD2 is down-regulated in hepatocellular carcinoma tissues and cell lines. Functional assays show circSETD2 acts as a tumor suppressor by inhibiting proliferation, colony formation, migration and invasion, inducing G0/G1 arrest, and reducing xenograft tumor growth, accompanied by changes in EMT/invasion-related proteins (E-cadherin, N-cadherin, Vimentin, MMP-2/9)."	0.6831
35260179	Journal of experimental & clinical cancer research : CR	2022	A novel protein encoded by circHNRNPU promotes multiple myeloma progression by regulating the bone marrow microenvironment and alternative splicing.	hsa_circ_0017272	circHNRNPU / circ-HNRNPU	hsa_circ_HNRNPU	HNRNPU	multiple myeloma / MM	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR; ISH; Microarray	"circHNRNPU (hsa_circ_0017272) is up-regulated in IgD MM/MM and associated with inferior clinical outcomes. It is secreted via exosomes and can be translated into circHNRNPU_603aa, which promotes MM proliferation and cell-cycle progression by regulating SKP2 exon skipping to reduce c-Myc ubiquitination and stabilize c-Myc."	0.8792
35261900	Translational cancer research	2022	"Circular RNA circTADA2A promotes the proliferation, invasion, and migration of non-small cell lung cancer cells via the miR-450b-3p/HMGN5 signaling pathway."		circTADA2A	hsa_circ_TADA2A	TADA2A	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circTADA2A is up-regulated in NSCLC tissues and cell lines and its high expression is associated with poorer overall survival. Functionally, circTADA2A promotes NSCLC cell proliferation, migration and invasion by acting as a ceRNA that sponges miR-450b-3p and thereby upregulates HMGN5 expression."	0.7113
35263216	Bioengineered	2022	Circular RNA UBAP2 facilitates the cisplatin resistance of triple-negative breast cancer via microRNA-300/anti-silencing function 1B histone chaperone/PI3K/AKT/mTOR axis.		Circular RNA UBAP2 (circUBAP2) / CircUBAP2	hsa_circ_UBAP2	UBAP2	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; RNA-seq	"circUBAP2 is upregulated in TNBC, especially in cisplatin-resistant (DDP-resistant) cells, and its knockdown sensitizes TNBC cells to DDP. Mechanistically, circUBAP2 sponges miR-300 to increase ASF1B expression, thereby activating PI3K/AKT/mTOR signaling and promoting chemoresistance and malignant phenotypes."	0.753
35264058	Bioengineered	2022	Knockdown of circ_0001679 alleviates lipopolysaccharide-induced MLE-12 lung cell injury by regulating the miR-338-3p/ mitogen-activated protein kinase 1 axis.	mmu_circ_0001679	circ_0001679 / circRNA_0001679			acute lung injury / ALI	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR	"In LPS-induced MLE-12 cell injury (ALI model), circ_0001679 is up-regulated and promotes inflammatory cytokine production and apoptosis while suppressing cell growth. Mechanistically, it functions as a ceRNA by sponging miR-338-3p to maintain MAPK1 expression; circ_0001679 knockdown alleviates LPS-induced injury via the miR-338-3p/MAPK1 axis."	0.6253
35264065	Bioengineered	2022	Circular RNA coiled-coil domain containing 66 regulates malignant development of papillary thyroid carcinoma by upregulating La ribonucleoprotein 1 via the sponge effect on miR-129-5p.		CircRNA coiled-coil domain containing 66 (circ-CCDC66) / circ-CCDC66	hsa_circ_CCDC66	CCDC66	papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circ-CCDC66 is up-regulated in papillary thyroid carcinoma and acts as an oncogenic circRNA. It mainly localizes in the cytoplasm and promotes PTC proliferation, migration, invasion, and xenograft tumor growth by sponging miR-129-5p to increase LARP1 expression, and its high expression is associated with poorer prognosis/advanced clinicopathologic features."	0.8656
35264067	Bioengineered	2022	Hsa_circ_0000418 promotes the progression of glioma by regulating microRNA-409-3p / pyruvate dehydrogenase kinase 1 axis.	hsa_circ_0000418	circ_0000418			glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; Microarray	"circ_0000418 is up-regulated in glioma tissues and cell lines and promotes glioma cell proliferation and cell-cycle progression. Mechanistically, it acts as a ceRNA by sponging miR-409-3p to indirectly increase PDK1 expression (circ_0000418/miR-409-3p/PDK1)."	0.7404
35264070	Bioengineered	2022	Circular RNA_ANKIB1 accelerates chemo-resistance of osteosarcoma via binding microRNA-26b-5p and modulating enhancer of zeste homolog 2.	hsa_circ_0009112	circular RNA_ANKIB1 / circ_ANKIB1	hsa_circ_ANKIB1	ANKIB1	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ_ANKIB1 is up-regulated in osteosarcoma, especially in DXR-resistant tissues/cells. It promotes DXR chemoresistance and malignant behaviors by sponging miR-26b-5p to upregulate EZH2, which increases resistance-related proteins (MRP1, P-gp, LRP); circ_ANKIB1 knockdown suppresses DXR-resistant tumor growth in vivo."	0.7631
35264957	Frontiers in pharmacology	2022	Hsa_Circ_0098181 Suppresses Hepatocellular Carcinoma by Sponging miR-18a-3p and Targeting PPARA.	hsa_circ_0098181	circ_0098181	hsa_circ_SOX5	SOX5	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; ISH; RNA-seq	"hsa_circ_0098181 is down-regulated in HCC tissues/cell lines and acts as a tumor suppressor. It mainly localizes in the cytoplasm and inhibits malignant phenotypes by sponging miR-18a-3p to derepress PPARA, reducing tumor growth in a xenograft model; low expression is associated with poor prognosis."	0.8657
35264957	Frontiers in pharmacology	2022	Hsa_Circ_0098181 Suppresses Hepatocellular Carcinoma by Sponging miR-18a-3p and Targeting PPARA.	hsa_circ_0072309				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0072309 was selected from RNA-seq data and its decreased level in paired HCC tissues was observed by RT-qPCR, but no further functional or mechanistic experiments were reported for this circRNA."	0.1904
35265724	Burns & trauma	2022	CircRNA_Maml2 promotes the proliferation and migration of intestinal epithelial cells after severe burns by regulating the miR-93-3p/FZD7/Wnt/beta-catenin pathway.	mmu_circ_0015409	circRNA_Maml2 / mmu_circRNA_43775	mmu_circ_Maml2	Maml2	severe burns	MONDO:0043519	burn	down-regulated	RT-qPCR	"circRNA_Maml2 is down-regulated in intestinal tissues after severe burns. Its overexpression promotes intestinal epithelial cell proliferation and migration and improves intestinal mucosal repair by sponging miR-93-3p, thereby upregulating FZD7 and activating Wnt/beta-catenin signaling."	0.8355
35266323	Molecular genetics & genomic medicine	2022	CircFOXM1 acts as a ceRNA to upregulate SMAD2 and promote the progression of nasopharyngeal carcinoma.	hsa_circ_0025042	circFOXM1	hsa_circ_FOXM1	FOXM1	nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"circFOXM1 is up-regulated in nasopharyngeal carcinoma and mainly localized in the cytoplasm. It promotes NPC cell proliferation, migration, invasion and EMT by acting as a ceRNA that sponges miR-136-5p to increase SMAD2 expression. High circFOXM1 expression is associated with advanced stage and poor prognosis."	0.8396
35274492	Cancer medicine	2022	circITCH suppresses cell proliferation and metastasis through miR-660/TFCP2 pathway in melanoma.		circITCH / Circular RNA ITCH (circITCH)	hsa_circ_ITCH	ITCH	melanoma	MONDO:0005105	melanoma	down-regulated	RT-qPCR	"circITCH is down-regulated in melanoma tissues and acts as a tumor suppressor by inhibiting melanoma cell proliferation and metastasis. Mechanistically, circITCH predominantly localizes in the cytoplasm and functions as a ceRNA to sponge miR-660, thereby upregulating TFCP2 via an Ago2/RISC-associated interaction."	0.7295
35274778	Journal of clinical laboratory analysis	2022	hsa_circ_0058122 knockdown prevents steroid-induced osteonecrosis of the femoral head by inhibiting human umbilical vein endothelial cells apoptosis via the miR-7974/IGFBP5 axis.	hsa_circ_0058122	circFN1	hsa_circ_FN1	FN1	steroid-induced osteonecrosis of the femoral head / SONFH	MONDO:0012126	familial avascular necrosis of femoral head	up-regulated	RT-qPCR; Microarray	"hsa_circ_0058122 (circFN1), derived from FN1, is up-regulated in SONFH femoral head tissues and in DEX-treated HUVECs. It promotes DEX-induced endothelial apoptosis by sponging miR-7974 and upregulating IGFBP5 (hsa_circ_0058122/miR-7974/IGFBP5 axis)."	0.7791
35277182	Molecular cancer	2022	Circ-ZEB1 promotes PIK3CA expression by silencing miR-199a-3p and affects the proliferation and apoptosis of hepatocellular carcinoma.		circ-ZEB1	hsa_circ_ZEB1	ZEB1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"Circ-ZEB1 is up-regulated in HCC and associated with poor prognosis. Functionally, circ-ZEB1 promotes HCC cell proliferation and suppresses apoptosis, and its knockdown inhibits xenograft tumor growth. Mechanistically, circ-ZEB1 binds and depletes miR-199a-3p, relieving repression of PIK3CA and increasing PIK3CA mRNA/protein expression."	0.798
35277458	Journal for immunotherapy of cancer	2022	CircITGB6 promotes ovarian cancer cisplatin resistance by resetting tumor-associated macrophage polarization toward the M2 phenotype.	hsa_circ_0056856	circITGB6	hsa_circ_ITGB6	ITGB6	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circITGB6 (hsa_circ_0056856) is upregulated in cisplatin-resistant ovarian cancer tissues and serum and is associated with poor prognosis. It promotes cisplatin resistance by acting as a cytoplasmic scaffold to form a circITGB6/IGF2BP2/FGF9 RNA_protein ternary complex that stabilizes FGF9 mRNA, increasing FGF9-driven TAM polarization toward an M2 phenotype and thereby creating an immunosuppressive, chemoresistant microenvironment."	0.8747
35278674	Molecular therapy : the journal of the American Society of Gene Therapy	2022	hnRNPL-activated circANKRD42 back-splicing and circANKRD42-mediated crosstalk of mechanical stiffness and biochemical signal in lung fibrosis.		circANKRD42 / hsa-circ-100906	hsa_circ_ANKRD42	ANKRD42	idiopathic pulmonary fibrosis / IPF	MONDO:0800504	idiopathic pulmonary fibrosis	up-regulated	RT-qPCR; Microarray	"circANKRD42 is up-regulated in IPF and acts as a profibrotic circRNA that increases fibroblast activation, proliferation/migration, ECM protein expression, and mechanical stiffness. Mechanistically, hnRNP L promotes its biogenesis, and circANKRD42 sponges miR-324-5p and miR-136-5p to elevate AJUBA and YAP1, enhancing Hippo/YAP signaling and YAP1 nuclear activity."	0.8809
35279129	"Journal of inflammation (London, England)"	2022	CircRNA circFADS2 is under-expressed in sepsis and protects lung cells from LPS-induced apoptosis by downregulating miR-133a.		hsa_circRNA_100833 / circFADS2	hsa_circ_FADS2	FADS2	sepsis	MONDO:0005229	bacterial infectious disease with sepsis	down-regulated	RT-qPCR	"circFADS2 is downregulated in sepsis plasma and in LPS-treated human bronchial epithelial cells. Functionally, circFADS2 overexpression protects HBEpCs from LPS-induced apoptosis and loss of viability by sponging/downregulating miR-133a, supported by luciferase and gain/loss-of-function assays."	0.6521
35279159	Journal of orthopaedic surgery and research	2022	"Circ_0001174 facilitates osteosarcoma cell proliferation, migration, and invasion by targeting the miR-186-5p/MACC1 axis."	hsa_circ_0001174	circ_0001174			osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; RNA-seq	"circ_0001174 is up-regulated in osteosarcoma tissues and cell lines and promotes OS cell proliferation, migration, and invasion. It acts as a ceRNA by sponging miR-186-5p, thereby increasing MACC1 expression and associating with shorter disease-free survival."	0.7369
35279965	Cell journal	2022	Circ_0000228 Promotes Cervical Cancer Progression via Regulating miR-337-3p /TGFBR1 Axis.	hsa_circ_0000228	circ_0000228	hsa_circ_ZEB1	ZEB1	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; RNA-seq	"circ_0000228 is up-regulated in cervical cancer tissues/cells and acts as an oncogenic circRNA. It promotes proliferation, migration, invasion and lung metastasis by sponging miR-337-3p to increase TGFBR1 expression."	0.742
35280687	International journal of biological sciences	2022	Circular RNA circDVL1 inhibits clear cell renal cell carcinoma progression through the miR-412-3p/PCDH7 axis.	hsa_circ_0009267	circDVL1	hsa_circ_DVL1	DVL1	clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	down-regulated	RT-qPCR; Microarray	"circDVL1 is down-regulated in ccRCC serum and tumor tissues and acts as a tumor suppressor. It mainly localizes to the cytoplasm and sponges miR-412-3p to relieve repression of PCDH7, thereby inhibiting proliferation, cell-cycle progression, migration/invasion and promoting apoptosis. Serum circDVL1 shows diagnostic potential for ccRCC (reported AUC 0.8083) and correlates with Fuhrman grade."	0.8769
35280778	Frontiers in oncology	2022	Identification of circRNA-miRNA-Immune-Related mRNA Regulatory Network in Gastric Cancer.	hsa_circ_0003763				Gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0003763 is down-regulated in gastric cancer and is part of a proposed ceRNA subnetwork hsa_circ_0003763_hsa-miR-145-5p_FGF10. The authors suggest this network may contribute to GC proliferation, migration, and invasion, potentially involving Rap1 and Ras signaling."	0.4032
35280778	Frontiers in oncology	2022	Identification of circRNA-miRNA-Immune-Related mRNA Regulatory Network in Gastric Cancer.	hsa_circ_0004928				Gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0004928 is reported as up-regulated in gastric cancer based on integrated GEO analyses and additional electronic validation datasets, and its expression trend was further checked by qRT-PCR in blood from a small cohort. No specific downstream miRNA/mRNA axis or mechanism was established for this circRNA in the paper."	0.4032
35280778	Frontiers in oncology	2022	Identification of circRNA-miRNA-Immune-Related mRNA Regulatory Network in Gastric Cancer.	hsa_circ_0040573				Gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	Microarray	"hsa_circ_0040573 is reported as up-regulated in gastric cancer by integrated microarray analysis and external dataset validation. The paper proposes a ceRNA pair hsa_circ_0040573_hsa-miR-3686_RAC1 (with immune-cell correlation), suggesting involvement in GC malignant transformation and metastasis, but without experimental mechanistic assays."	0.1768
35281715	Frontiers in cell and developmental biology	2021	Strategy for Scanning Peptide-Coding Circular RNAs in Colorectal Cancer Based on Bioinformatics Analysis and Experimental Assays.	hsa_circ_0000725	circBANP-306aa	hsa_circ_BANP	BANP	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000725 (BANP-derived) is up-regulated in CRC and can encode a peptide (circBANP-306aa). Knockdown in DLD-1 cells inhibits proliferation/colony formation and invasion, induces G0/G1 arrest and increases apoptosis."	0.7421
35281715	Frontiers in cell and developmental biology	2021	Strategy for Scanning Peptide-Coding Circular RNAs in Colorectal Cancer Based on Bioinformatics Analysis and Experimental Assays.	hsa_circ_0008826	circDHTKD1-475aa	hsa_circ_DHTKD1	DHTKD1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	dysregulated	RT-qPCR; Microarray	"hsa_circ_0008826 (DHTKD1-derived) shows variable expression across CRC cell lines and can encode a peptide (circDHTKD1-475aa). Knockdown in DLD-1 cells inhibits proliferation/colony formation and invasion, with subtle cell-cycle changes and no detectable apoptosis effect."	0.7421
35281849	Frontiers in genetics	2022	CircATRNL1 and circZNF608 Inhibit Ovarian Cancer by Sequestering miR-152-5p and Encoding Protein.	hsa_circ_0001523	circZNF608	hsa_circ_ZNF608	ZNF608	ovarian cancer / OC	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR; RNA-seq	"circZNF608 (hsa_circ_0001523) is down-regulated in ovarian cancer tissues and functions as a tumor suppressor by inhibiting ovarian cancer cell proliferation, migration, and invasion. Mechanistically, it sequesters miR-152-5p as a miRNA sponge."	0.7211
35281849	Frontiers in genetics	2022	CircATRNL1 and circZNF608 Inhibit Ovarian Cancer by Sequestering miR-152-5p and Encoding Protein.	hsa_circ_0020093	circATRNL1	hsa_circ_ATRNL1	ATRNL1	ovarian cancer / OC	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR; RNA-seq	"circATRNL1 (hsa_circ_0020093) is down-regulated in ovarian cancer tissues and suppresses ovarian cancer cell proliferation, migration, and invasion. Mechanistically, it has protein-coding capacity and encodes a 131-aa protein driven by an IRES/ORF feature validated by FLAG-tag western blot."	0.7296
35284481	Frontiers in surgery	2022	hsa_circ_0072309 Expression Profiling in Non-small-Cell Lung Carcinoma and Its Implications for Diagnosis and Prognosis.	hsa_circ_0072309		hsa_circ_LIFR	LIFR	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0072309 (LIFR) is down-regulated in NSCLC and is associated with lymph node metastasis, advanced stage, and poorer survival when expressed at low levels. It also shows diagnostic value (AUC 0.887), with improved performance when combined with CEA or CYFRA21-1; the mechanism was not deeply explored."	0.5734
35284630	Molecular therapy oncolytics	2022	Hsa_circ_0001666 promotes non-small cell lung cancer migration and invasion through miR-1184/miR-548I/AGO1 axis.	hsa_circ_0001666	circ0001666	hsa_circ_FAM120B	FAM120B	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001666 (circ0001666), derived from FAM120B, is upregulated in NSCLC tissues and cell lines and is mainly localized in the cytoplasm. It promotes NSCLC migration and invasion in vitro and metastasis in a mouse model by sponging miR-1184 and miR-548I, thereby upregulating AGO1 and activating PI3K/AKT/mTOR signaling; high expression is associated with lymph node metastasis, advanced stage, and poorer survival."	0.8745
35287543	Bioengineered	2022	Hsa_circ_0017639 regulates cisplatin resistance and tumor growth via acting as a miR-1296-5p molecular sponge and modulating sine oculis homeobox 1 expression in non-small cell lung cancer.	hsa_circ_0017639	circ_0017639 / hsa_circRNA_100542			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"In DDP-resistant NSCLC, circ_0017639 is up-regulated and mainly localized in the cytoplasm. It promotes cisplatin resistance and malignant phenotypes by sponging miR-1296-5p, thereby increasing SIX1 expression, and its knockdown sensitizes tumors/cells to DDP and inhibits tumor growth in vivo."	0.7956
35287604	BMC cancer	2022	Circ_0064288 acts as an oncogene of hepatocellular carcinoma cells by inhibiting miR-335-5p expression and promoting ROCK1 expression.	hsa_circ_0064288	circ_0064288 / circRNA_103285	hsa_circ_ATG7	ATG7	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0064288 is up-regulated in hepatocellular carcinoma and promotes proliferation and migration. It mainly localizes to the cytoplasm and acts as a ceRNA sponge for miR-335-5p, thereby increasing ROCK1 expression. High circ_0064288 expression is associated with shorter overall survival in HCC patients."	0.7474
35288538	Cell death & disease	2022	Autophagy-associated circRNA circATG7 facilitates autophagy and promotes pancreatic cancer progression.	hsa_circ_0064288	circ-autophagy related 7 (circATG7) / circATG7	hsa_circ_ATG7	ATG7	pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; ISH; Microarray	"circATG7 is up-regulated in pancreatic cancer tissues and cell lines and is associated with more aggressive clinicopathologic features and poorer overall survival. Functionally, circATG7 promotes proliferation, migration/invasion, metastasis, EMT and autophagy via a dual mechanism: cytoplasmic sponging of miR-766-5p to increase ATG7 expression and nuclear recruitment of HUR to enhance ATG7 mRNA stability, leading to ATG7-dependent autophagic flux."	0.8901
35291714	"Open medicine (Warsaw, Poland)"	2022	circRNA_0001679/miR-338-3p/DUSP16 axis aggravates acute lung injury.	mmu_circ_0001679	circRNA_0001679 / (mmu)-circ_0001679	mmu_circ_klhl2	klhl2	acute lung injury / ALI	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR	"mmu-circ_0001679 is upregulated in LPS-induced sepsis-associated ALI models (MLE-12 cells and mouse lung tissue). Functionally, circ_0001679 promotes inflammatory cytokine production and apoptosis, worsening lung injury and permeability. Mechanistically, it sponges miR-338-3p to de-repress DUSP16, and DUSP16 overexpression rescues the inhibitory effects of circ_0001679 knockdown."	0.5627
35291991	BMC endocrine disorders	2022	Circ_0000064 promotes high glucose-induced renal tubular epithelial cells injury to facilitate diabetic nephropathy progression through miR-532-3p/ROCK1 axis.	hsa_circ_0000064	circ_0000064	hsa_circ_B4GALT2	B4GALT2	diabetic nephropathy / DN	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"circ_0000064 is up-regulated in DN patient serum and in HG-treated HK-2 cells, and it aggravates HG-induced renal tubular epithelial cell injury (oxidative stress, apoptosis and fibrosis) while suppressing proliferation. Mechanistically, it functions as a ceRNA by sponging miR-532-3p to increase ROCK1, and knockdown of circ_0000064 alleviates injury via the miR-532-3p/ROCK1 axis."	0.7045
35293280	Bioengineered	2022	Circular RNA circ_0002360 regulates the Taxol resistance and malignant behaviors of Taxol-resistant non-small cell lung cancer cells by microRNA-585-3p-dependent modulation of G protein regulated inducer of neurite outgrowth 1.	hsa_circ_0002360	circ_0002360	hsa_circ_RUNX1		non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0002360 is up-regulated in Taxol-resistant NSCLC and mainly localized in the cytoplasm. It promotes Taxol resistance and malignant behaviors (proliferation, migration/invasion) and suppresses apoptosis by sponging miR-585-3p to increase GPRIN1 expression, and circ_0002360 knockdown sensitizes tumors to Taxol in a xenograft model."	0.8443
35295711	Journal of oncology	2022	Downregulation of Circular RNA circPSD3 Promotes Metastasis by Modulating FBXW7 Expression in Clear Cell Renal Cell Carcinoma.	hsa_circ_0002111	circPSD3	hsa_circ_PSD3	PSD3	clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	down-regulated	RT-qPCR; RNA-seq; Microarray	"circPSD3 (hsa_circ_0002111), derived from PSD3, is down-regulated in ccRCC tissues and cell lines and is associated with metastasis. Functionally, circPSD3 suppresses migration/invasion, EMT, and lung metastasis by sponging miR-25-3p to upregulate FBXW7, forming the circPSD3/miR-25-3p/FBXW7-EMT axis."	0.8693
35295950	Frontiers in genetics	2022	Differently Expressed Circular RNAs in Lacrimal Sacs From Patients With Chronic Dacryocystitis.	hsa_circ_0004792				chronic dacryocystitis	MONDO:0004925	chronic dacryocystitis	up-regulated	RT-qPCR; RNA-seq	"has_circ_0004792 is up-regulated in lacrimal sac samples from chronic dacryocystitis patients versus controls, identified by RNA-seq and validated by RT-qPCR. The study does not report a specific downstream miRNA/mRNA mechanism for has_circ_0004792."	0.3588
35295950	Frontiers in genetics	2022	Differently Expressed Circular RNAs in Lacrimal Sacs From Patients With Chronic Dacryocystitis.	hsa_circ_0001062				chronic dacryocystitis	MONDO:0004925	chronic dacryocystitis	up-regulated	RT-qPCR; RNA-seq	"has_circ_0001062 is up-regulated in lacrimal sac samples from chronic dacryocystitis patients versus controls, identified by RNA-seq and validated by RT-qPCR. The study does not provide a specific mechanistic axis for has_circ_0001062."	0.3588
35295950	Frontiers in genetics	2022	Differently Expressed Circular RNAs in Lacrimal Sacs From Patients With Chronic Dacryocystitis.	hsa_circ_0115476				chronic dacryocystitis	MONDO:0004925	chronic dacryocystitis	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0115476 (also written as has_circ_0115476) is down-regulated in chronic dacryocystitis lacrimal sac tissue and was validated by RT-qPCR. Bioinformatic ceRNA network analysis suggests it may sponge hsa-miR-7152-3p to regulate CD4, potentially affecting CD4+ T-cell infiltration/Th1-Th2-related immune processes in chronic dacryocystitis."	0.4032
35297094	Journal of clinical laboratory analysis	2022	Serum hsa_circ_0079480 is a novel prognostic marker for acute myeloid leukemia.	hsa_circ_0079480				acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"Serum hsa_circ_0079480 is up-regulated in AML patients versus healthy controls and can discriminate AML from controls. High serum hsa_circ_0079480 predicts worse OS/RFS and is an independent prognostic factor; its level decreases after chemotherapy and is lower in patients achieving complete remission, suggesting value for monitoring treatment response."	0.4992
35297212	Thoracic cancer	2022	Circ_0003340 downregulation mitigates esophageal squamous cell carcinoma progression by targeting miR-940/PRKAA1 axis.	hsa_circ_0003340				esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"circ_0003340 is up-regulated in ESCC tissues and cell lines and mainly localized in the cytoplasm. Functionally, circ_0003340 promotes ESCC malignant phenotypes (proliferation, migration/invasion, and angiogenesis) and suppresses apoptosis, while its knockdown inhibits tumor growth in a xenograft model. Mechanistically, it acts as a ceRNA by sponging miR-940 to increase PRKAA1 expression (circ_0003340/miR-940/PRKAA1 axis), and high circ_0003340 correlates with poorer patient survival."	0.7981
35300071	Journal of immunology research	2022	Circular RNA RHOT1 Regulates miR-142-5p/CCND1 to Participate in Chondrocyte Autophagy and Proliferation in Osteoarthritis.			hsa_circ_RHOT1	RHOT1	Osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	circRHOT1 is up-regulated in osteoarthritis cartilage and promotes OA-associated chondrocyte proliferation while suppressing autophagy. It functions as a ceRNA by sponging miR-142-5p to increase CCND1 expression; circRHOT1 knockdown reverses OA phenotypes in rat ACLT model and in chondrocytes.	0.6545
35300347	Journal of oncology	2022	Circular RNA VANGL1 Facilitates Migration and Invasion of Papillary Thyroid Cancer by Modulating the miR-194/ZEB1/EMT Axis.			hsa_circ_VANGL1	VANGL1	papillary thyroid cancer / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circVANGL1 is up-regulated in papillary thyroid cancer and promotes proliferation, migration, invasion and EMT. It mainly localizes to the cytoplasm and acts as a ceRNA by sponging miR-194 to de-repress ZEB1, contributing to PTC progression."	0.6777
35302432	Bioengineered	2022	Hsa_circ_0000081 promotes the function of gastric cancer through sponging hsa-miR-423-5p to influence 3-phosphoinositide-dependent kinase 1 expression.	hsa_circ_0000081				Gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000081 is up-regulated in gastric cancer tissues and cell lines and is associated with shorter patient survival. It promotes GC cell proliferation, migration, and invasion by acting as a cytoplasmic sponge for miR-423-5p, thereby increasing PDPK1 expression."	0.8484
35302673	Journal of clinical laboratory analysis	2022	Hsa_circRNA_0017620 regulated cell progression of non-small-cell lung cancer via miR-520a-5p/KRT5 axis.	hsa_circ_0017620		hsa_circ_SFMBT2	SFMBT2	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0017620 is up-regulated in NSCLC tissues and cell lines and promotes proliferation, migration/invasion and in vivo tumor growth. Mechanistically, it functions as a ceRNA by sponging miR-520a-5p to increase KRT5, and miR-520a-5p inhibition or KRT5 overexpression rescues the effects of hsa_circ_0017620 knockdown."	0.7856
35305647	Molecular cancer	2022	The N6-methyladenosine modification of circALG1 promotes the metastasis of colorectal cancer mediated by the miR-342-5p/PGF signalling pathway.		circALG1	hsa_circ_ALG1	ALG1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circALG1 is up-regulated in colorectal cancer tissues and peripheral blood and promotes CRC metastasis by enhancing migration and invasion. Mechanistically, m6A-modified circALG1 (recognized by YTHDF1) sponges miR-342-5p to upregulate PGF, which activates ERK/MAPK and EMT-associated changes."	0.8861
35306484	Aging	2022	Circular RNA circ_0001006 aggravates cardiac hypertrophy via miR-214-3p/PAK6 axis.	hsa_circ_0001006	circ_0001006			cardiac hypertrophy	MONDO:0005045	hypertrophic cardiomyopathy	up-regulated	RT-qPCR; Microarray	"circ_0001006 is upregulated in TAC-induced cardiac hypertrophy and Ang II-treated cardiomyocytes, promotes hypertrophic phenotypes, and its knockdown alleviates hypertrophy. Mechanistically, circ_0001006 sponges miR-214-3p to increase PAK6, forming a circ_0001006/miR-214-3p/PAK6 regulatory axis."	0.657
35307984	Thoracic cancer	2022	CircATIC inhibits esophageal carcinoma progression and promotes radiosensitivity by elevating RHCG through sponging miR-10-3p.	hsa_circ_0058058	hsa_circ_102913	hsa_circ_ATIC	ATIC	esophageal carcinoma	MONDO:0019086	carcinoma of esophagus	down-regulated	RT-qPCR	"CircATIC is down-regulated in ESCA and acts as a tumor suppressor that enhances radiosensitivity. Mechanistically, it sponges miR-10b-3p to relieve repression of RHCG, thereby inhibiting malignant behaviors and radioresistance."	0.8039
35308166	Oxidative medicine and cellular longevity	2022	Circular RNA_0057209 Acts as ceRNA to Inhibit Thyroid Cancer Progression by Promoting the STK4-Mediated Hippo Pathway via Sponging MicroRNA-183.	hsa_circ_0057209	hsa_circ_102862	hsa_circ_TTN-AS1	TTN-AS1	thyroid cancer / TC	MONDO:0002108	thyroid cancer	down-regulated	RT-qPCR; RNA-seq	"circRNA_0057209 is down-regulated in thyroid cancer and functions as a tumor suppressor. It sponges miR-183 to relieve repression of STK4, promoting Hippo pathway activation (increased YAP phosphorylation) and thereby inhibiting proliferation/migration/invasion while promoting apoptosis and reducing xenograft tumor growth."	0.8354
35309118	Frontiers in genetics	2022	Identification of a Novel Survival-Related circRNA-miRNA-mRNA Regulatory Network Related to Immune Infiltration in Liver Hepatocellular Carcinoma.	hsa_circ_0017264		hsa_circ_ADSS	ADSS	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0017264 is up-regulated in LIHC tissues and is proposed to act in a ceRNA network by sequestering hsa-miR-195-5p, thereby affecting CHEK1/CDC25A/FOXK1. This axis is linked to cell-cycle and cancer-related pathways and is associated with immune infiltration/immune checkpoint correlations, suggesting a role in LIHC progression and immune escape."	0.6556
35309118	Frontiers in genetics	2022	Identification of a Novel Survival-Related circRNA-miRNA-mRNA Regulatory Network Related to Immune Infiltration in Liver Hepatocellular Carcinoma.	hsa_circ_0000854		hsa_circ_ZCCHC2	ZCCHC2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000854 was identified as significantly up-regulated in LIHC based on GEO analysis and was experimentally verified by RT-qPCR/Sanger sequencing in clinical specimens, but no specific downstream mechanism or clinical impact was reported for this circRNA."	0.585
35309118	Frontiers in genetics	2022	Identification of a Novel Survival-Related circRNA-miRNA-mRNA Regulatory Network Related to Immune Infiltration in Liver Hepatocellular Carcinoma.	hsa_circ_0005307		hsa_circ_CYP20A1	CYP20A1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0005307 was identified as significantly up-regulated in LIHC and validated in clinical specimens, but the paper did not specify its downstream miRNA/mRNA targets or functional mechanism."	0.585
35309118	Frontiers in genetics	2022	Identification of a Novel Survival-Related circRNA-miRNA-mRNA Regulatory Network Related to Immune Infiltration in Liver Hepatocellular Carcinoma.	hsa_circ_0006286		hsa_circ_YAP1	YAP1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0006286 was found up-regulated in LIHC and validated in clinical specimens, but no specific miRNA/mRNA axis or functional experiments were provided for this circRNA in this study."	0.585
35309118	Frontiers in genetics	2022	Identification of a Novel Survival-Related circRNA-miRNA-mRNA Regulatory Network Related to Immune Infiltration in Liver Hepatocellular Carcinoma.	hsa_circ_0034049		hsa_circ_TUBGCP5	TUBGCP5	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0034049 was identified as up-regulated in LIHC and validated in clinical tissues, but the study did not establish a specific mechanistic axis or functional role for it."	0.585
35309118	Frontiers in genetics	2022	Identification of a Novel Survival-Related circRNA-miRNA-mRNA Regulatory Network Related to Immune Infiltration in Liver Hepatocellular Carcinoma.	hsa_circ_0035946		hsa_circ_DENND4A	DENND4A	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0035946 is up-regulated in LIHC and was validated in clinical specimens, but no specific interaction partners, pathways, or functional assays were reported for it."	0.585
35309118	Frontiers in genetics	2022	Identification of a Novel Survival-Related circRNA-miRNA-mRNA Regulatory Network Related to Immune Infiltration in Liver Hepatocellular Carcinoma.	hsa_circ_0051488		hsa_circ_ERCC1	ERCC1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0051488 was validated as up-regulated in LIHC tissues in this study, but the paper did not define its LIHC-specific targets/mechanism; it only noted prior evidence of a miRNA sponge role in another cancer type."	0.585
35310884	Frontiers in molecular neuroscience	2022	Expression of Circ_Satb1 Is Decreased in Mesial Temporal Lobe Epilepsy and Regulates Dendritic Spine Morphology.	hsa_circ_0064555	circ_Satb1 / circ_00136_SATB1	hsa_circ_SATB1	SATB1	Temporal Lobe Epilepsy / TLE	MONDO:0005115	temporal lobe epilepsy	down-regulated	RT-qPCR; RNA-seq	"circ_Satb1 (SATB1-derived) is down-regulated in the hippocampus of mTLE patients and also decreased in a chronic-stage kainate mouse model. CRISPR/CasRx-mediated circ_Satb1 knockdown in primary hippocampal neurons reduces complex/branched dendritic spines, indicating a role in dendritic spine morphology/maturation and potential relevance to epileptogenesis. circ_Satb1 levels correlate positively with postoperative seizure-free period, suggesting possible predictive value for surgical outcome."	0.7331
35310884	Frontiers in molecular neuroscience	2022	Expression of Circ_Satb1 Is Decreased in Mesial Temporal Lobe Epilepsy and Regulates Dendritic Spine Morphology.	mmu_circ_0006823	circ_Satb1 / circ_00136_SATB1	mmu_circ_SATB1	SATB1	Temporal Lobe Epilepsy / TLE	MONDO:0005115	temporal lobe epilepsy	down-regulated	RT-qPCR; RNA-seq	"circ_Satb1 (SATB1-derived) is down-regulated in the hippocampus of mTLE patients and also decreased in a chronic-stage kainate mouse model. CRISPR/CasRx-mediated circ_Satb1 knockdown in primary hippocampal neurons reduces complex/branched dendritic spines, indicating a role in dendritic spine morphology/maturation and potential relevance to epileptogenesis. circ_Satb1 levels correlate positively with postoperative seizure-free period, suggesting possible predictive value for surgical outcome."	0.7331
35310884	Frontiers in molecular neuroscience	2022	Expression of Circ_Satb1 Is Decreased in Mesial Temporal Lobe Epilepsy and Regulates Dendritic Spine Morphology.	hsa_circ_0006011	circ_Satb2 / circ_00310_SATB2	hsa_circ_SATB2	SATB2	Temporal Lobe Epilepsy / TLE	MONDO:0005115	temporal lobe epilepsy	down-regulated	RT-qPCR; RNA-seq	"circ_Satb2 is down-regulated in the hippocampus of mTLE patients versus controls, supported by RNA-seq and RT-qPCR validation. The study does not further define a mechanism or functional role for circ_Satb2 beyond its differential expression in mTLE."	0.5541
35310884	Frontiers in molecular neuroscience	2022	Expression of Circ_Satb1 Is Decreased in Mesial Temporal Lobe Epilepsy and Regulates Dendritic Spine Morphology.	hsa_circ_0000378	circ_Lrp6 / circ_00468_LRP6	hsa_circ_LRP6	LRP6	Temporal Lobe Epilepsy / TLE	MONDO:0005115	temporal lobe epilepsy	down-regulated	RT-qPCR; RNA-seq	"circ_Lrp6 is down-regulated in mTLE patient hippocampus compared with controls, supported by RNA-seq and RT-qPCR validation. The paper does not further characterize circ_Lrp6 mechanism or functional effects."	0.5541
35310916	Journal of oncology	2022	hsa_circ_0077837 Alleviated the Malignancy of Non-Small Cell Lung Cancer by Regulating the miR-1178-3p/APITD1 Axis.	hsa_circ_0077837	circ_0077837			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"hsa_circ_0077837 is down-regulated in NSCLC tissues and cell lines and acts as a tumor-suppressive circRNA. It sponges miR-1178-3p to relieve repression of the downstream target APITD1, thereby inhibiting proliferation/viability, migration and invasion while promoting apoptosis, and suppressing xenograft tumor growth."	0.7132
35310917	Journal of oncology	2022	Circular RNA hsa_circ_0004543 Aggravates Cervical Cancer Development by Sponging MicroRNA hsa-miR-217 to Upregulate Hypoxia-Inducible Factor.	hsa_circ_0004543	circ_0004543			cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	hsa_circ_0004543 is up-regulated in cervical cancer tissues and cell lines. It promotes proliferation/colony formation and migration/invasion while inhibiting apoptosis by acting as a ceRNA that sponges hsa-miR-217 to upregulate HIF-1alpha.	0.7045
35311456	Bioengineered	2022	"Hsa_circ_0072008 regulates cell proliferation, migration, and invasion in cervical squamous cell carcinoma via miR-1305/helicase, lymphoid specific (HELLS) axis."	hsa_circ_0072008	circ_0072008			cervical squamous cell carcinoma / CSCC	MONDO:0006143	cervical squamous cell carcinoma	up-regulated	RT-qPCR	"circ_0072008 is up-regulated in CESC tissues/cells and promotes malignant phenotypes (proliferation, migration, invasion) while suppressing apoptosis. Mechanistically, it acts as a ceRNA sponging miR-1305 to upregulate HELLS, and its knockdown suppresses xenograft tumor growth."	0.8171
35312113	Journal of clinical laboratory analysis	2022	CircRNA hsa_circ_0018289 exerts an oncogenic role in cervical cancer progression through miR-1294/ICMT axis.	hsa_circ_0018289	circSYT15_003	hsa_circ_SYT15	SYT15	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"hsa_circ_0018289 is up-regulated in cervical cancer tissues/cells and promotes malignant phenotypes including proliferation, migration/invasion, glycolysis, and tumor growth. Mechanistically, it acts as a ceRNA by sponging miR-1294 to increase ICMT expression, forming a hsa_circ_0018289/miR-1294/ICMT axis."	0.8034
35312115	Journal of clinical laboratory analysis	2022	Hsa_circ_0007142 contributes to cisplatin resistance in esophageal squamous cell carcinoma via miR-494-3p/LASP1 axis.	hsa_circ_0007142	circ_0007142	hsa_circ_DOCK1	DOCK1	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"hsa_circ_0007142 (circ_0007142) is upregulated in cisplatin-resistant ESCC tissues and DDP-resistant cell models. Functionally, it promotes cisplatin resistance, proliferation and invasion while suppressing apoptosis by sponging miR-494-3p to increase LASP1 expression, and its knockdown enhances DDP sensitivity in vitro and in a xenograft model."	0.7859
35313983	Veterinary research	2022	Profiling and functional analysis of differentially expressed circular RNAs identified in foot-and-mouth disease virus infected PK-15 cells.		circ12	hsa_circ_KPNB1	KPNB1	foot-and-mouth disease / FMD	MONDO:0005765	foot and mouth disease	up-regulated	RT-qPCR; RNA-seq	This circRNA (host gene KPNB1) is up-regulated in FMDV-infected PK-15 cells and was among the differentially expressed circRNAs validated by qRT-PCR. Its specific mechanistic role in FMDV infection was not functionally characterized beyond enrichment-based analyses.	0.437
35313983	Veterinary research	2022	Profiling and functional analysis of differentially expressed circular RNAs identified in foot-and-mouth disease virus infected PK-15 cells.		circ6	hsa_circ_VPS35	VPS35	foot-and-mouth disease / FMD	MONDO:0005765	foot and mouth disease	up-regulated	RT-qPCR; RNA-seq	This circRNA (host gene VPS35) is up-regulated in FMDV-infected PK-15 cells and was among the differentially expressed circRNAs validated by qRT-PCR. The study did not define a specific molecular mechanism for this circRNA.	0.437
35313983	Veterinary research	2022	Profiling and functional analysis of differentially expressed circular RNAs identified in foot-and-mouth disease virus infected PK-15 cells.		circ6	hsa_circ_CEP192	CEP192	foot-and-mouth disease / FMD	MONDO:0005765	foot and mouth disease	down-regulated	RT-qPCR; RNA-seq	"circ6:96667496_96668320 (host gene CEP192) is down-regulated after FMDV infection in PK-15 cells and is discussed as being involved in cell cycle regulation. No direct mechanistic axis (e.g., miRNA targets) was experimentally established."	0.437
35313983	Veterinary research	2022	Profiling and functional analysis of differentially expressed circular RNAs identified in foot-and-mouth disease virus infected PK-15 cells.		circ2	hsa_circ_DDX39A	DDX39A	foot-and-mouth disease / FMD	MONDO:0005765	foot and mouth disease	down-regulated	RT-qPCR; RNA-seq	"circ2:64840343_64840811 (host gene DDX39A) is down-regulated in FMDV-infected PK-15 cells. It was discussed as being involved in DNA damage repair/nucleic acid metabolism/transport processes, but no specific mechanism was experimentally tested."	0.437
35313983	Veterinary research	2022	Profiling and functional analysis of differentially expressed circular RNAs identified in foot-and-mouth disease virus infected PK-15 cells.		circ7	hsa_circ_DICER1	DICER1	foot-and-mouth disease / FMD	MONDO:0005765	foot and mouth disease	down-regulated	RT-qPCR; RNA-seq	"circ7:116401757_116406130 (host gene DICER1) is down-regulated after FMDV infection in PK-15 cells. It was discussed as potentially related to DNA damage repair/nucleic acid metabolism and transport processes, without mechanistic validation."	0.437
35313983	Veterinary research	2022	Profiling and functional analysis of differentially expressed circular RNAs identified in foot-and-mouth disease virus infected PK-15 cells.		circ2	hsa_circ_HSPA4	HSPA4	foot-and-mouth disease / FMD	MONDO:0005765	foot and mouth disease	down-regulated	RT-qPCR; RNA-seq	"circ2:135356735_135368467 (host gene HSPA4) is down-regulated in FMDV-infected PK-15 cells. The paper hypothesizes a possible involvement in autophagy/immune evasion, but this was not experimentally validated."	0.437
35313983	Veterinary research	2022	Profiling and functional analysis of differentially expressed circular RNAs identified in foot-and-mouth disease virus infected PK-15 cells.		circ6	hsa_circ_RCC1	RCC1	foot-and-mouth disease / FMD	MONDO:0005765	foot and mouth disease	down-regulated	RT-qPCR; RNA-seq	circ6:85556400_85558524 (host gene RCC1) is down-regulated after FMDV infection in PK-15 cells and is discussed as potentially involved in cell cycle regulation. No specific downstream targets were analyzed.	0.437
35313983	Veterinary research	2022	Profiling and functional analysis of differentially expressed circular RNAs identified in foot-and-mouth disease virus infected PK-15 cells.		circ6	hsa_circ_USP48	USP48	foot-and-mouth disease / FMD	MONDO:0005765	foot and mouth disease	down-regulated	RT-qPCR; RNA-seq	"circ6:79779444_79787224 (host gene USP48) is down-regulated after FMDV infection in PK-15 cells. The paper links it to ubiquitin processing and speculates it may relate to FMDV Lpro-mediated immune escape, without direct mechanistic experiments."	0.437
35317442	Experimental and therapeutic medicine	2022	Circular RNA hsa_circ_0011946 promotes the malignant process of salivary adenoid cystic carcinoma by downregulating miR-1205 expression.	hsa_circ_0011946				salivary adenoid cystic carcinoma / SACC	MONDO:0003175	salivary gland adenoid cystic carcinoma	up-regulated	RT-qPCR	"hsa_circ_0011946 is upregulated in SACC tissues and promotes SACC cell proliferation, migration, invasion and EMT. Mechanistically, it functions as a miRNA sponge that negatively regulates miR-1205, and miR-1205 inhibition partially rescues the effects of hsa_circ_0011946 knockdown."	0.6815
35317519	Molecular therapy oncolytics	2022	CircRHBDD1 augments metabolic rewiring and restricts immunotherapy efficacy via m6A modification in hepatocellular carcinoma.	hsa_circ_0058497	circRHBDD1	hsa_circ_RHBDD1	RHBDD1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circRHBDD1 is up-regulated in HCC and promotes proliferation and glycolysis. It acts as a scaffold to recruit YTHDF1 to PIK3R1 mRNA, enhancing m6A-dependent translation of PIK3R1 and activating PI3K/AKT signaling, thereby promoting tumor growth and reducing anti-PD-1 therapy efficacy."	0.9002
35317525	Molecular therapy oncolytics	2022	Circular RNA circLAMA3 inhibits the proliferation of bladder cancer by directly binding an mRNA.	hsa_circ_0047253	circLAMA3	hsa_circ_LAMA3	LAMA3	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; Microarray	"circLAMA3 (hsa_circ_0047253), derived from LAMA3, is down-regulated in bladder cancer and suppresses malignant phenotypes. It primarily localizes to the nucleus and directly binds MYCN mRNA to accelerate its degradation, lowering MYCN protein and reducing CDK6 transcription/levels, which induces G0/G1 arrest and inhibits tumor growth."	0.8837
35317822	Journal of translational medicine	2022	CircESRP1 enhances metastasis and epithelial-mesenchymal transition in endometrial cancer via the miR-874-3p/CPEB4 axis.	hsa_circ_0084927	circESRP1 / circ0084927	hsa_circ_ESRP1	ESRP1	endometrial cancer / EC	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR	"circESRP1 is upregulated in endometrial cancer and mainly localizes to the cytoplasm. It promotes EC cell proliferation, migration/invasion, tumour growth and EMT by acting as a ceRNA that sponges miR-874-3p to increase CPEB4 expression."	0.8704
35318303	Cell death discovery	2022	High-dose-androgen-induced autophagic cell death to suppress the Enzalutamide-resistant prostate cancer growth via altering the circRNA-BCL2/miRNA-198/AMBRA1 signaling.		circRNA-BCL2 / circBCL2	hsa_circ_BCL2	BCL2	castration-resistant prostate cancer / CRPC	MONDO:0850353	castration-resistant prostate carcinoma	down-regulated	RT-qPCR	"In Enzalutamide-resistant CRPC cells, high-dose DHT suppresses circRNA-BCL2 (from host gene BCL2). Reduced circRNA-BCL2 decreases miR-198 stability/levels, leading to increased AMBRA1 and induction of autophagic cell death that suppresses tumor cell growth; circRNA-BCL2 overexpression partially reverses this effect."	0.7941
35318311	Cell death discovery	2022	CircRBM33 downregulation inhibits hypoxia-induced glycolysis and promotes apoptosis of breast cancer cells via a microRNA-542-3p/HIF-1alpha axis.		circRBM33	hsa_circ_RBM33	RBM33	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circRBM33 is up-regulated in breast cancer tissues/cell lines and further induced by hypoxia. Functionally, circRBM33 promotes glycolysis and proliferation and inhibits apoptosis in BCa cells by sponging miR-542-3p, thereby increasing HIF-1alpha expression."	0.6996
35320976	Oxidative medicine and cellular longevity	2022	Identification and Characterization of the Roles of circCASP9 in Gastric Cancer Based on a circRNA-miRNA-mRNA Regulatory Network.	hsa_circ_0010039	circCASP9	hsa_circ_CASP9	CASP9	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"circCASP9 is down-regulated in gastric cancer tissues and cell lines and functions as a tumor suppressor. It sponges miR-589-5p to upregulate KANK1, thereby inhibiting proliferation, migration/invasion, tumor growth, and liver metastasis."	0.774
35321280	World journal of gastrointestinal oncology	2022	RNA-Seq profiling of circular RNAs in human colorectal cancer 5-fluorouracil resistance and potential biomarkers.	hsa_circ_0002813	circ_0002813			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0002813 is up-regulated in 5-Fu-resistant CRC cell lines and is proposed to promote 5-Fu resistance via a ceRNA network, including an axis involving miRNAs (e.g., miR-1343-3p/miR-541-3p) and FUT3. It is suggested as a potential biomarker and therapeutic target for 5-Fu resistance in CRC."	0.2465
35321280	World journal of gastrointestinal oncology	2022	RNA-Seq profiling of circular RNAs in human colorectal cancer 5-fluorouracil resistance and potential biomarkers.	hsa_circ_0000236	circ_0000236			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000236 is up-regulated in 5-Fu-resistant CRC cell lines and is implicated in promoting 5-Fu resistance via a predicted ceRNA mechanism. The study proposes axes such as circ_0000236_miR4769-5p_PLAG1 and (speculatively) circ_0000236_miR-4796-5p_TNS4, and suggests biomarker potential for predicting 5-Fu resistance."	0.2465
35321280	World journal of gastrointestinal oncology	2022	RNA-Seq profiling of circular RNAs in human colorectal cancer 5-fluorouracil resistance and potential biomarkers.	hsa_circ_0122168				colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0122168 is up-regulated in 5-Fu-resistant CRC cell line pairs and is proposed to participate in 5-Fu resistance, with a predicted involvement in circRNA-miRNA-mRNA (ceRNA) networks. It is suggested as a potential predictive biomarker/therapeutic target for 5-Fu resistance."	0.2465
35321280	World journal of gastrointestinal oncology	2022	RNA-Seq profiling of circular RNAs in human colorectal cancer 5-fluorouracil resistance and potential biomarkers.	hsa_circ_0031584				colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0031584 is up-regulated in 5-Fu-resistant CRC cell line pairs and is proposed to contribute to 5-Fu resistance. The study predicts it participates in circRNA-miRNA-mRNA (ceRNA) regulatory networks and suggests biomarker/target potential for 5-Fu resistance.	0.2465
35321280	World journal of gastrointestinal oncology	2022	RNA-Seq profiling of circular RNAs in human colorectal cancer 5-fluorouracil resistance and potential biomarkers.	hsa_circ_0006877				colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0006877 is generally up-regulated in 5-Fu-resistant CRC cell lines (except not significantly changed in SW480). It is proposed to be involved in 5-Fu resistance with predicted ceRNA network involvement and suggested as a potential biomarker/therapeutic target for 5-Fu resistance.	0.2465
35321435	Frontiers in oncology	2022	Circular RNA circLMO1 Suppresses Cervical Cancer Growth and Metastasis by Triggering miR-4291/ACSL4-Mediated Ferroptosis.	hsa_circ_0021087	circLMO1	hsa_circ_LMO1	LMO1	cervical cancer / CC	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR	"circLMO1 (Hsa_circ_0021087) is down-regulated in cervical cancer and suppresses tumor growth, invasion, and metastasis. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-4291, thereby up-regulating ACSL4 and promoting ferroptosis."	0.849
35321689	BMC cancer	2022	Circ_0058063 contributes to cisplatin-resistance of bladder cancer cells by upregulating B2M through acting as RNA sponges for miR-335-5p.	hsa_circ_0058063				bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circ_0058063 is up-regulated in cisplatin (CDDP)-resistant bladder cancer tissues and resistant cell lines and is associated with poorer overall survival. Functionally, circ_0058063 promotes CDDP resistance, proliferation, tumor growth, and stemness while inhibiting apoptosis. Mechanistically, it acts as a ceRNA that sponges miR-335-5p to increase B2M expression, and miR-335-5p inhibition rescues the effects of circ_0058063 knockdown on CDDP sensitivity."	0.8586
35322101	Scientific reports	2022	Identification of potentially functional circular RNAs hsa_circ_0070934 and hsa_circ_0004315 as prognostic factors of hepatocellular carcinoma by integrated bioinformatics analysis.	hsa_circ_0070934		hsa_circ_LARP1B	LARP1B	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	Microarray	"hsa_circ_0070934 is identified as an upregulated DEC in HCC based on integrated GEO microarray analysis and is modeled as a ceRNA that sponges hsa-miR-511-5p, thereby potentially de-repressing survival-related hub genes in HCC. The study proposes it as a potential prognostic factor, but lacks experimental validation."	0.1768
35322101	Scientific reports	2022	Identification of potentially functional circular RNAs hsa_circ_0070934 and hsa_circ_0004315 as prognostic factors of hepatocellular carcinoma by integrated bioinformatics analysis.	hsa_circ_0004315		hsa_circ_GLG1	GLG1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	Microarray	"hsa_circ_0004315 is identified as an upregulated DEC in HCC based on integrated GEO microarray analysis and is modeled as a ceRNA that sponges hsa-miR-195-5p/hsa-miR-214-3p/hsa-miR-424-5p, potentially increasing survival-related hub gene expression. The study proposes it as a prognostic factor, pending experimental validation."	0.1768
35322736	Bioengineered	2022	Circ_0005526 contributes to interleukin-1beta-induced chondrocyte injury in osteoarthritis via upregulating transcription factor 4 by interacting with miR-142-5p.	hsa_circ_0005526	circ_0005526	hsa_circ_RUNX2	RUNX2	osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circ_0005526 is up-regulated in OA cartilage and IL-1beta-treated chondrocytes. It promotes IL-1beta-induced chondrocyte injury by sponging miR-142-5p, thereby increasing TCF4 expression and enhancing apoptosis and inflammatory responses while reducing viability/proliferation."	0.7581
35331286	Journal of orthopaedic surgery and research	2022	Circ_0043947 contributes to interleukin 1beta-induced injury in chondrocytes by sponging miR-671-5p to up-regulate RTN3 expression in osteoarthritis pathology.	hsa_circ_0043947	circ_0043947	hsa_circ_BRCA1	BRCA1	Osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"In IL-1beta-stimulated human chondrocytes (an in vitro OA model), circ_0043947 is up-regulated and exacerbates injury phenotypes including reduced viability/proliferation and increased apoptosis, ECM degradation and inflammation. Mechanistically, circ_0043947 sponges miR-671-5p to de-repress RTN3 (circ_0043947/miR-671-5p/RTN3 axis), and circ_0043947 knockdown is protective."	0.7624
35332692	CNS neuroscience & therapeutics	2022	Knockdown of circ_0055412 promotes cisplatin sensitivity of glioma cells through modulation of CAPG and Wnt/beta-catenin signaling pathway.	hsa_circ_0055412	circ_CAPG / circ_0055412	hsa_circ_CAPG	CAPG	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ_0055412 (circ_CAPG) is up-regulated in glioma cells and promotes cisplatin resistance. Mechanistically, it recruits EIF4A3 to stabilize CAPG mRNA and acts as a miR-330-3p sponge to increase NFATC3, which enhances CTNNB1 transcription and activates Wnt/beta-catenin signaling, promoting proliferation and inhibiting apoptosis under cisplatin treatment."	0.8027
35333693	Bioengineered	2022	Cancer-released exosomal circular RNA circ_0008717 promotes cell tumorigenicity through microRNA-1287-5p/P21-activated kinase 2 (PAK2) axis in non-small cell lung cancer.	hsa_circ_0008717	circ_0008717 / circABCB10	hsa_circ_ABCB10	ABCB10	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0008717 (circABCB10) is up-regulated in NSCLC tissues, cells, and patient serum-derived exosomes. It promotes NSCLC malignant phenotypes and tumor growth by acting as a ceRNA to sponge miR-1287-5p, thereby increasing PAK2 expression, and it is packaged into exosomes enabling extracellular transfer."	0.8035
35334496	Journal of clinical laboratory analysis	2022	Circ_SAR1A regulates the malignant behavior of lung cancer cells via the miR-21-5p/TXNIP axis.		circ_SAR1A / circ_SAR1A	hsa_circ_SAR1A	SAR1A	lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	"circ_SAR1A is down-regulated in lung cancer and functions as a tumor suppressor. It mainly localizes to the cytoplasm and sponges miR-21-5p to derepress TXNIP, thereby inhibiting proliferation, migration/invasion and tumor growth while promoting apoptosis."	0.7799
35334500	Journal of clinical laboratory analysis	2022	Biological and clinical implications of hsa_circ_0086720 in gastric cancer and its clinical application.	hsa_circ_0086720		hsa_circ_UBAP2	UBAP2	gastric cancer / GC	MONDO:0001056	gastric cancer	dysregulated	RT-qPCR; Microarray	"This study reports hsa_circ_0086720 as dysregulated in gastric carcinogenesis: decreased in GC/EGC tissues but increased in EGC plasma. It supports clinical utility as a plasma biomarker for early GC screening (ROC AUC 0.771) and indicates prognostic relevance via OS/DFS stratification. Mechanistically, it is predicted to interact with miR-34c-5p and the miR-449 family and may be secreted into plasma via exosomes."	0.6522
35338119	Cell death & disease	2022	CircTHBS1 drives gastric cancer progression by increasing INHBA mRNA expression and stability in a ceRNA- and RBP-dependent manner.	hsa_circ_0034536	circTHBS1	hsa_circ_THBS1	THBS1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circTHBS1 (hsa_circ_0034536) is up-regulated in gastric cancer and promotes proliferation, EMT, invasion, and metastasis. It increases INHBA expression through dual mechanisms: sponging miR-204-5p (ceRNA) and binding HuR to enhance INHBA mRNA stability, thereby activating TGF-beta/SMAD signaling and associating with poor prognosis."	0.8933
35340241	Journal of healthcare engineering	2022	CircNR3C1 Alleviates Gastric Cancer Development by Inactivating AKT/mTOR.		circNR3C1	hsa_circ_NR3C1	NR3C1	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"circNR3C1 is down-regulated in gastric cancer tissues/cells and functions as a tumor suppressor by inhibiting GC cell proliferation and migration. Mechanistically, it inactivates the AKT/mTOR signaling pathway by reducing AKT and mTOR levels, and low circNR3C1 expression is associated with lymphatic/distant metastasis."	0.5358
35340554	Oncology letters	2022	Identification of potential circular RNA biomarkers in lung adenocarcinoma: A bioinformatics analysis and retrospective clinical study.	hsa_circ_0006220				lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0006220 is up-regulated in lung adenocarcinoma tissues, and higher expression is associated with poorer prognosis. Knockdown suppresses LAC cell proliferation, migration, and invasion, and bioinformatic networks suggest a potential ceRNA role involving miRNAs and hub genes (e.g., miR-520f/KIF2C)."	0.7842
35340554	Oncology letters	2022	Identification of potential circular RNA biomarkers in lung adenocarcinoma: A bioinformatics analysis and retrospective clinical study.	hsa_circ_0072088				lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0072088 is up-regulated in lung adenocarcinoma and higher expression is associated with poorer prognosis. Its knockdown inhibits LAC cell proliferation, migration, and invasion, and network analysis suggests a potential ceRNA axis involving miR-1270/MELK and miR-1261/BIRC5."	0.7842
35340554	Oncology letters	2022	Identification of potential circular RNA biomarkers in lung adenocarcinoma: A bioinformatics analysis and retrospective clinical study.	hsa_circ_0001666				lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001666 is up-regulated in lung adenocarcinoma and higher expression is associated with poorer prognosis. Knockdown inhibits LAC cell proliferation, migration, and invasion, and network analysis suggests potential ceRNA regulation of hub genes via miR-940 and miR-661 (e.g., KIF18B, CKAP2L) and miR-188-3p (PLK1)."	0.7842
35340708	International journal of genomics	2022	Circ_0078767 Inhibits the Progression of Non-Small-Cell Lung Cancer by Regulating the GPX3 Expression by Adsorbing miR-665.	hsa_circ_0078767				non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	circ_0078767 is down-regulated in NSCLC tissues/cells and mainly localizes to the cytoplasm. Loss of circ_0078767 promotes NSCLC malignant phenotypes and glycolysis and accelerates xenograft tumor growth by sponging miR-665 to reduce GPX3 expression (circ_0078767/miR-665/GPX3 axis).	0.6815
35342341	International journal of biological sciences	2022	CircRAPGEF5 Promotes the Proliferation and Metastasis of Lung Adenocarcinoma through the miR-1236-3p/ZEB1 Axis and Serves as a Potential Biomarker.	hsa_circ_0001681	circRAPGEF5	hsa_circ_RAPGEF5	RAPGEF5	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circRAPGEF5 (hsa_circ_0001681) is up-regulated in LAD tissues/cells and in exosomes. It promotes LAD proliferation, migration, invasion and EMT, at least partly by sponging miR-1236-3p to increase ZEB1 expression; exosomal circRAPGEF5 can transfer pro-metastatic signals between cells. Serum exosomal circRAPGEF5 shows diagnostic potential, especially when combined with CEA."	0.7954
35345511	Journal of oncology	2022	circSYPL1 Promotes the Proliferation and Metastasis of Hepatocellular Carcinoma via the Upregulation of EZH2 Expression by Competing with hsa-miR-506-3p.		circSYPL1	hsa_circ_SYPL1	SYPL1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circSYPL1 is upregulated in HCC tissues/cell lines and promotes malignant phenotypes (proliferation, invasion/metastasis) while inhibiting apoptosis. Mechanistically, it functions as a ceRNA that sponges miR-506-3p to increase EZH2 expression, and perturbing miR-506-3p or EZH2 reverses circSYPL1-driven effects."	0.7552
35345604	Cancer management and research	2022	CircRNA6783 Inhibits Cell Proliferation and Promotes Apoptosis in Lung Adenocarcinoma.		circRNA6783	hsa_circ_VRK2	VRK2	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"circRNA6783 is up-regulated in lung adenocarcinoma, detectable in peripheral whole blood and LA cells. Overexpression in NCI-H1975 inhibits proliferation and increases apoptosis, suggesting potential as a noninvasive diagnostic biomarker; the molecular mechanism is not experimentally defined, with only predicted miRNA interactions."	0.6304
35346026	Cellular & molecular biology letters	2022	CircRbms1 knockdown alleviates hypoxia-induced cardiomyocyte injury via regulating the miR-742-3p/FOXO1 axis.	mmu_circ_0001022	circRbms1	mmu_circ_Rbms1	Rbms1	myocardial infarction / MI	MONDO:0005068	myocardial infarction	up-regulated	RT-qPCR	"In MI mouse hearts and hypoxia-injured H9c2 cardiomyocytes, mmu_circ_0001022 (circRbms1) is up-regulated and exacerbates cardiomyocyte injury. Mechanistically, it sponges miR-742-3p to de-repress FOXO1, leading to reduced proliferation/migration/invasion and increased apoptosis; circRbms1 knockdown is protective."	0.8115
35346268	Journal of orthopaedic surgery and research	2022	"Hsa_circ_0001017 promotes cell proliferation, migration and invasion in osteosarcoma by sponging miR-145-5p."	hsa_circ_0001017	circ_0001017			osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001017 is up-regulated in osteosarcoma cell lines and functions as an oncogenic circRNA. It promotes proliferation, migration and invasion and inhibits apoptosis in U2OS cells by sponging miR-145-5p and negatively regulating its expression."	0.627
35346268	Journal of orthopaedic surgery and research	2022	"Hsa_circ_0001017 promotes cell proliferation, migration and invasion in osteosarcoma by sponging miR-145-5p."	hsa_circ_0000704				osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000704 was identified by microarray and validated by RT-qPCR as up-regulated in osteosarcoma cell lines compared with osteoblast cell lines, but no functional or mechanistic experiments were reported for this circRNA in this study."	0.1904
35346268	Journal of orthopaedic surgery and research	2022	"Hsa_circ_0001017 promotes cell proliferation, migration and invasion in osteosarcoma by sponging miR-145-5p."	hsa_circ_0005035				osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0005035 was identified by microarray and validated by RT-qPCR as up-regulated in osteosarcoma cell lines compared with osteoblast cell lines, but no functional or mechanistic experiments were reported for this circRNA in this study."	0.1904
35346278	Journal of orthopaedic surgery and research	2022	LPS-inducible circAtp9b is highly expressed in osteoporosis and promotes the apoptosis of osteoblasts by reducing the formation of mature miR-17-92a.		circAtp9b	hsa_circ_Atp9b	Atp9b	Osteoporosis / OP	MONDO:0005298	osteoporosis	up-regulated	RT-qPCR	"In osteoporosis, circAtp9b is up-regulated in patient plasma and is induced by LPS in osteoblasts. circAtp9b localizes to both nucleus and cytoplasm, directly binds premature miR-17-92a and suppresses its maturation, reducing mature miR-17-92a levels and promoting osteoblast apoptosis."	0.6166
35346905	Anatolian journal of cardiology	2022	Circular RNA hsa_circ_0000848 Regulates Cardiomyocyte Proliferation and Apoptosis Under Hypoxia via Recruiting ELAVL1 and Stabilizing SMAD7 mRNA.	hsa_circ_0000848	circ_SMAD7 / circ_0000848	hsa_circ_SMAD7	SMAD7	myocardial infarction / MI	MONDO:0005068	myocardial infarction	down-regulated	RT-qPCR	"hsa_circ_0000848 is down-regulated in hypoxia-induced cardiomyocytes. Its knockdown suppresses proliferation and increases apoptosis. Mechanistically, it binds the RBP ELAVL1 to enhance SMAD7 mRNA stability and SMAD7 expression, and SMAD7 overexpression rescues the effects of hsa_circ_0000848 silencing."	0.7909
35347818	Cancer science	2022	"circ_0006089 promotes gastric cancer growth, metastasis, glycolysis, and angiogenesis by regulating miR-361-3p/TGFB1."	hsa_circ_0006089	circ_0006089	hsa_circ_ASAP2	ASAP2	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circ_0006089 is up-regulated in gastric cancer tissues and cells and mainly localizes to the cytoplasm. It promotes proliferation, migration/invasion, glycolysis and angiogenesis while inhibiting apoptosis, largely via a ceRNA mechanism in which circ_0006089 sponges miR-361-3p to increase TGFB1 expression; knockdown suppresses tumor growth in xenografts."	0.8256
35349390	Bioengineered	2022	"Circular RNA PLCE1 promotes epithelial mesenchymal transformation, glycolysis in colorectal cancer and M2 polarization of tumor-associated macrophages."		circPLCE1 / circRNA PLCE1	hsa_circ_PLCE1	PLCE1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circPLCE1 is up-regulated in colorectal cancer and promotes tumor growth, EMT and glycolysis, while driving tumor-associated macrophage polarization toward the M2 phenotype. Mechanistically, it functions as a ceRNA by sponging miR-485-5p to increase ACTG1, forming a circPLCE1/miR-485-5p/ACTG1 axis."	0.7548
35351136	Molecular cancer	2022	Hypoxia-induced circWSB1 promotes breast cancer progression through destabilizing p53 by interacting with USP10.	hsa_circ_0007716	circWSB1	hsa_circ_WSB1	WSB1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; ISH; Microarray	"In breast cancer, circWSB1 (hsa_circ_0007716) is induced by hypoxia via HIF1alpha and is up-regulated in tumor tissues. circWSB1 promotes tumor cell proliferation and xenograft growth by binding USP10 and disrupting USP10-mediated p53 deubiquitination, resulting in p53 destabilization and suppression of p53 signaling."	0.8995
35354791	Cell death discovery	2022	Hsa_circ_0007967 promotes gastric cancer proliferation through the miR-411-5p/MAML3 axis.	hsa_circ_0007967		hsa_circ_ATF2	ATF2	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0007967 is up-regulated in gastric cancer tissues and cell lines. It mainly localizes to the cytoplasm and promotes gastric cancer cell proliferation in vitro and in a cell line-derived xenograft model by sponging miR-411-5p, thereby increasing MAML3 expression (a Notch-related transcriptional co-activator)."	0.8339
35355424	Thoracic cancer	2022	Circ_ZFR affects FABP7 expression to regulate breast cancer progression by acting as a sponge for miR-223-3p.			hsa_circ_ZFR	ZFR	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circ_ZFR is up-regulated in breast cancer tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion, EMT) while inhibiting apoptosis. Mechanistically, it functions as a ceRNA by sponging miR-223-3p to derepress FABP7, thereby enhancing tumor growth in vitro and in a cell line-derived xenograft model."	0.742
35355934	Chinese journal of cancer research = Chung-kuo yen cheng yen chiu	2022	"Deregulated expression and subcellular localization of CPSF6, a circRNA-binding protein, promote malignant development of esophageal squamous cell carcinoma."	hsa_circ_0000417	circCPSF6	hsa_circ_CPSF6	CPSF6	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	RT-qPCR	"circCPSF6 (hsa_circ_0000417), a circular isoform of CPSF6, is mainly localized in the cytoplasm of ESCC cells. It binds CPSF6 protein, and CPSF6 positively regulates circCPSF6 expression. Functionally, circCPSF6 supports malignant phenotypes by promoting G1/S cell-cycle progression and inhibiting apoptosis."	0.7326
35356749	Genetics research	2022	circRNA_101277 Influences Cisplatin Resistance of Colorectal Cancer Cells by Modulating the miR-370/IL-6 Axis.		circRNA_101277			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circRNA_101277 is upregulated in colorectal cancer and promotes tumor cell proliferation and cisplatin resistance. Mechanistically, it sponges miR-370 to upregulate IL-6, forming a circRNA_101277/miR-370/IL-6 ceRNA axis linked to poor overall survival and diagnostic discrimination between tumor and adjacent tissues."	0.7449
35358000	Bioengineered	2022	"Circular RNA LONP2 regulates proliferation, invasion, and apoptosis of bladder cancer cells by sponging microRNA-584-5p."		CircLONP2	hsa_circ_LONP2	LONP2	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; RNA-seq	"circLONP2 is up-regulated in bladder cancer tissues and cell lines and promotes malignant phenotypes (proliferation and invasion) while inhibiting apoptosis. Mechanistically, it sponges miR-584-5p to derepress YAP1, forming a circLONP2/miR-584-5p/YAP1 axis, and high circLONP2 expression predicts poorer overall survival."	0.8523
35359342	Journal of oncology	2022	Circular RNA TLK1 Exerts Oncogenic Functions in Hepatocellular Carcinoma by Acting as a ceRNA of miR-138-5p.	hsa_circ_0004442		hsa_circ_TLK1	TLK1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ-TLK1 is up-regulated in hepatocellular carcinoma tissues and cell lines and mainly localizes to the cytoplasm. It promotes HCC proliferation, migration, invasion, and EMT by sponging miR-138-5p and thereby de-repressing SOX4."	0.7372
35359572	Frontiers in molecular neuroscience	2022	Hsa_circ_0031608: A Potential Modulator of VSMC Phenotype in the Rupture of Intracranial Aneurysms.	hsa_circ_0031608	circ_0031608	hsa_circ_SNX6	SNX6	intracranial aneurysm / IA	MONDO:0005291 	brain aneurysm	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0031608 is up-regulated in ruptured intracranial aneurysm tissues and increases during TNF-alpha_induced VSMC phenotypic transformation. Overexpression promotes a pro-inflammatory VSMC phenotype (¡ýalpha-SMA/calponin, ¡üMMP-2) and enhances VSMC migration and proliferation, with a predicted (but not experimentally validated) circRNA_miRNA_mRNA ceRNA network."	0.7571
35359600	Frontiers in molecular biosciences	2022	Identification of circRNA Biomarker for Gastric Cancer through Integrated Analysis.		circCEACAM5	hsa_circ_CEACAM5	CEACAM5	Gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	circCEACAM5 is up-regulated in gastric cancer tissues versus adjacent normal tissues and was validated by RT-qPCR. Bioinformatic analyses suggest it may sponge GC-related miRNAs (including hsa-miR-429) and it shows high diagnostic performance by ROC analysis (AUC 0.96).	0.5963
35359600	Frontiers in molecular biosciences	2022	Identification of circRNA Biomarker for Gastric Cancer through Integrated Analysis.		circCOL1A1	hsa_circ_COL1A1	COL1A1	Gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	circCOL1A1 is up-regulated in gastric cancer tissues versus adjacent normal tissues and was validated by RT-qPCR. Bioinformatic analyses suggest it may sponge GC-related miRNAs (including hsa-miR-21-3p and hsa-miR-145-5p) and it shows diagnostic potential by ROC analysis (AUC 0.94).	0.5963
35359600	Frontiers in molecular biosciences	2022	Identification of circRNA Biomarker for Gastric Cancer through Integrated Analysis.		circMISP	hsa_circ_MISP	MISP	Gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	circMISP is up-regulated in gastric cancer tissues versus adjacent normal tissues and its expression change was validated by RT-qPCR. Its interactions with multiple miRNAs were predicted by miRanda-based bioinformatic analysis.	0.5135
35359600	Frontiers in molecular biosciences	2022	Identification of circRNA Biomarker for Gastric Cancer through Integrated Analysis.		circLIPF	hsa_circ_LIPF	LIPF	Gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; RNA-seq	circLIPF is down-regulated in gastric cancer tissues versus adjacent normal tissues and its expression change was validated by RT-qPCR. Its interactions with multiple miRNAs were predicted by bioinformatic analysis.	0.5135
35359600	Frontiers in molecular biosciences	2022	Identification of circRNA Biomarker for Gastric Cancer through Integrated Analysis.		circPGC	hsa_circ_PGC	PGC	Gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; RNA-seq	circPGC is down-regulated in gastric cancer tissues versus adjacent normal tissues and its expression change was validated by RT-qPCR. No specific mechanism or clinical implication was reported for circPGC in this study.	0.4773
35360228	Frontiers in physiology	2022	Microarray Analysis Reveals the Changes in Circular RNA Expression and Molecular Mechanisms in Mice With Ventilator-Induced Lung Injury.		novel_circ_0000899			ventilator-induced lung injury / VILI	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR; RNA-seq	novel_circ_0000899 is up-regulated in mouse lung tissue after ventilator-induced lung injury (VILI) and was validated by RT-qPCR. The study further predicts that it may participate in VILI via a circRNA-miRNA-mRNA (ceRNA) regulatory network based on miRanda/Cytoscape analysis.	0.6676
35360228	Frontiers in physiology	2022	Microarray Analysis Reveals the Changes in Circular RNA Expression and Molecular Mechanisms in Mice With Ventilator-Induced Lung Injury.		novel_circ_0014815			ventilator-induced lung injury / VILI	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR; RNA-seq	novel_circ_0014815 is up-regulated in mouse lung tissue in the VILI model and validated by RT-qPCR. The study predicts its potential role through a miRanda/Cytoscape-constructed circRNA-miRNA-mRNA (ceRNA) network.	0.6676
35360228	Frontiers in physiology	2022	Microarray Analysis Reveals the Changes in Circular RNA Expression and Molecular Mechanisms in Mice With Ventilator-Induced Lung Injury.		novel_circ_0004441			ventilator-induced lung injury / VILI	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR; RNA-seq	novel_circ_0004441 is up-regulated in lung tissue in the mouse VILI model and was validated by RT-qPCR. No specific downstream miRNA/mRNA axis for this circRNA was detailed in the text provided.	0.5618
35360228	Frontiers in physiology	2022	Microarray Analysis Reveals the Changes in Circular RNA Expression and Molecular Mechanisms in Mice With Ventilator-Induced Lung Injury.		novel_circ_0016568			ventilator-induced lung injury / VILI	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR; RNA-seq	novel_circ_0016568 is up-regulated in lung tissue in the mouse VILI model and was validated by RT-qPCR. No specific downstream mechanism was described for this circRNA in the provided text.	0.5618
35360228	Frontiers in physiology	2022	Microarray Analysis Reveals the Changes in Circular RNA Expression and Molecular Mechanisms in Mice With Ventilator-Induced Lung Injury.		novel_circ_0019935			ventilator-induced lung injury / VILI	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR; RNA-seq	novel_circ_0019935 is up-regulated in lung tissue in the mouse VILI model and was validated by RT-qPCR. No specific downstream mechanism was described for this circRNA in the provided text.	0.5618
35360228	Frontiers in physiology	2022	Microarray Analysis Reveals the Changes in Circular RNA Expression and Molecular Mechanisms in Mice With Ventilator-Induced Lung Injury.		novel_circ_0007829			ventilator-induced lung injury / VILI	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR; RNA-seq	novel_circ_0007829 is up-regulated in lung tissue in the mouse VILI model and was validated by RT-qPCR. No specific downstream mechanism was described for this circRNA in the provided text.	0.5618
35360228	Frontiers in physiology	2022	Microarray Analysis Reveals the Changes in Circular RNA Expression and Molecular Mechanisms in Mice With Ventilator-Induced Lung Injury.		novel_circ_0005213			ventilator-induced lung injury / VILI	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR; RNA-seq	novel_circ_0005213 is up-regulated in lung tissue in the mouse VILI model and was validated by RT-qPCR. No specific downstream mechanism was described for this circRNA in the provided text.	0.5618
35360228	Frontiers in physiology	2022	Microarray Analysis Reveals the Changes in Circular RNA Expression and Molecular Mechanisms in Mice With Ventilator-Induced Lung Injury.		novel_circ_0015069			ventilator-induced lung injury / VILI	MONDO:0015796	acute lung injury	down-regulated	RT-qPCR; RNA-seq	novel_circ_0015069 is down-regulated in mouse lung tissue after VILI and validated by RT-qPCR. The study predicts it may regulate downstream genes through a circRNA-miRNA-mRNA (ceRNA) network based on miRanda/Cytoscape analysis.	0.6676
35360228	Frontiers in physiology	2022	Microarray Analysis Reveals the Changes in Circular RNA Expression and Molecular Mechanisms in Mice With Ventilator-Induced Lung Injury.	mmu_circ_0000098				ventilator-induced lung injury / VILI	MONDO:0015796	acute lung injury	down-regulated	RT-qPCR; RNA-seq	mmu_circ_0000098 is down-regulated in mouse lung tissue after VILI and was validated by RT-qPCR. The study does not provide a specific downstream mechanism or interaction network for this circRNA in the provided text.	0.5618
35365168	Journal of translational medicine	2022	CircZDBF2 up-regulates RNF145 by ceRNA model and recruits CEBPB to accelerate oral squamous cell carcinoma progression via NFkappaB signaling pathway.	hsa_circ_0002141	hsa_circRNA_002141 / circZDBF2	hsa_circ_ZDBF2	ZDBF2	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circZDBF2 is up-regulated in OSCC cells and promotes proliferation, migration, invasion, EMT and xenograft tumor growth. Mechanistically, it sponges miR-362-5p/miR-500b-5p to de-repress RNF145 and also recruits CEBPB to enhance RNF145 transcription, leading to NF-kappaB activation and increased IL-8 transcription."	0.8546
35365169	World journal of surgical oncology	2022	"Circ_0047921 acts as the sponge of miR-1287-5p to stimulate lung cancer progression by regulating proliferation, migration, invasion, and glycolysis of lung cancer cells."	hsa_circ_0047921	circ_0047921	hsa_circ_CD266	CD266	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circ_0047921 is up-regulated in lung cancer/NSCLC tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion, EMT) and glycolysis. It functions mainly as a ceRNA by sponging miR-1287-5p, thereby increasing the downstream target LARP1, and its silencing suppresses xenograft tumor growth."	0.6536
35365208	Journal of experimental & clinical cancer research : CR	2022	CircSCAP interacts with SF3A3 to inhibit the malignance of non-small cell lung cancer by activating p53 signaling.	hsa_circ_0065214	circSCAP	hsa_circ_SCAP	SCAP	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Northern Blot; Microarray	"circSCAP (hsa_circ_0065214), derived from SCAP, is down-regulated in lung cancer/NSCLC and acts as a tumor suppressor. It binds SF3A3 and promotes SF3A3 ubiquitin_proteasome degradation, increasing MDM4-S and activating p53 signaling to inhibit proliferation/migration and promote apoptosis. Higher circSCAP expression is associated with better patient prognosis and has prognostic biomarker potential."	0.8913
35366240	Aging	2022	Circular RNA circGSE1 promotes angiogenesis in ageing mice by targeting the miR-323-5p/NRP1 axis.		circGSE1	mmu_circ_GSE1	GSE1	ageing			down-regulated	RT-qPCR; RNA-seq	"circGSE1 is down-regulated in aged mouse aortic endothelial cells and ischemic gastrocnemius muscle. It promotes endothelial proliferation, migration and tube formation, and improves blood-flow recovery/angiogenesis in an aging hindlimb ischemia model by sponging miR-323-5p to upregulate NRP1."	0.8218
35366241	Aging	2022	Hypoxic pretreatment of adipose-derived stem cell exosomes improved cognition by delivery of circ-Epc1 and shifting microglial M1/M2 polarization in an Alzheimer's disease mice model.		circ-Epc1	mmu_circ_Epc1	Epc1	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR; RNA-seq	"In APP/PS1 AD mice, hypoxia-pretreated ADSC exosomes deliver circ-Epc1 to the brain and improve cognition while reducing hippocampal neuronal apoptosis and inflammation. Mechanistically, circ-Epc1 sponges miR-770-3p to regulate TREM2, promoting microglial polarization toward the M2 phenotype."	0.7416
35366893	Molecular cancer	2022	Circular RNA MTCL1 promotes advanced laryngeal squamous cell carcinoma progression by inhibiting C1QBP ubiquitin degradation and mediating beta-catenin activation.	hsa_circ_0000825	circMTCL1	hsa_circ_MTCL1	MTCL1	laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circMTCL1 is up-regulated in LSCC and associated with worse overall survival. It promotes LSCC proliferation, migration/invasion and in vivo tumor growth/metastasis by directly binding C1QBP to inhibit its ubiquitin_proteasome degradation, thereby enhancing beta-catenin activation and Wnt/beta-catenin signaling."	0.89
35366894	Molecular cancer	2022	A novel peptide encoded by N6-methyladenosine modified circMAP3K4 prevents apoptosis in hepatocellular carcinoma.	hsa_circ_0078619	circMAP3K4	hsa_circ_MAP3K4	MAP3K4	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Northern Blot; ISH	"circMAP3K4 is upregulated in HCC and serves as an adverse prognostic factor. Via m6A modification, IGF2BP1 promotes translation of circMAP3K4 into the peptide circMAP3K4-455aa, which binds AIF to reduce AIF cleavage and nuclear translocation, thereby suppressing cisplatin-induced apoptosis and contributing to chemoresistance; the peptide is ubiquitinated by MIB1 for proteasomal degradation."	0.904
35368030	Cell death discovery	2022	CircRPAP2 regulates the alternative splicing of PTK2 by binding to SRSF1 in breast cancer.	hsa_circ_0000091	circRPAP2	hsa_circ_RPAP2	RPAP2	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	"circRPAP2 (hsa_circ_0000091) is down-regulated in breast cancer tissues and cell lines and acts as a tumor suppressor by inhibiting proliferation and migration. Mechanistically, it is mainly nuclear and binds the splicing factor SRSF1, competing with PTK2 pre-mRNA binding to attenuate SRSF1-mediated alternative splicing, thereby reducing PTK2 mRNA/protein and suppressing tumor growth in xenografts."	0.8533
35371308	Journal of Cancer	2022	Circular RNA circASPM promotes the progression of glioblastoma by acting as a competing endogenous RNA to regulate miR-130b-3p/E2F1 axis.	hsa_circ_0015772	circASPM	hsa_circ_ASPM	ASPM	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; Microarray	"circASPM (hsa_circ_0015772), derived from ASPM, is up-regulated in GBM and promotes GSC proliferation and tumorigenesis. It functions as a ceRNA that sponges miR-130b-3p, thereby increasing E2F1 expression and driving malignant progression, and high circASPM expression is associated with poor survival."	0.8562
35371319	Journal of Cancer	2022	circ_0000567/miR-421/TMEM100 Axis Promotes the Migration and Invasion of Lung Adenocarcinoma and Is Associated with Prognosis.	hsa_circ_0000567	circ_0000567	hsa_circ_SETD3	SETD3	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR	"circ_0000567 is down-regulated in LUAD tissues and cell lines. Functionally, circ_0000567 suppresses LUAD cell migration and invasion by sponging miR-421, thereby relieving miR-421-mediated repression of TMEM100 in a ceRNA network."	0.704
35372340	Frontiers in cell and developmental biology	2022	"circSSU72 Promotes Cell Proliferation, Migration and Invasion of Papillary Thyroid Carcinoma Cells by Targeting miR-451a/S1PR2 Axis."	hsa_circ_0009294		hsa_circ_SSU72	SSU72	papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circSSU72 (hsa_circ_0009294), a SSU72-derived circRNA, is up-regulated in papillary thyroid carcinoma and promotes proliferation, migration, and invasion. It acts as a ceRNA sponging miR-451a to de-repress S1PR2 and activate AKT signaling, and higher circSSU72 levels correlate with more aggressive clinicopathologic features."	0.7898
35373390	Journal of clinical laboratory analysis	2022	Hsa_circ_0060927 participates in the regulation of Caudatin on colorectal cancer malignant progression by sponging miR-421/miR-195-5p.	hsa_circ_0060927	circ_0060927			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"hsa_circ_0060927 is up-regulated in colorectal cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes malignant phenotypes (proliferation, migration/invasion) and suppresses apoptosis by sponging miR-421 and miR-195-5p, thereby counteracting Caudatin¡¯s anti-tumor effects."	0.8571
35373391	Journal of clinical laboratory analysis	2022	Hsa_circ_0058129 regulates papillary thyroid cancer development via miR-873-5p/follistatin-like 1 axis.	hsa_circ_0058129	circ_0058129	hsa_circ_FN1	FN1	papillary thyroid cancer / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circ_0058129 is up-regulated in papillary thyroid cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes PTC proliferation, cell-cycle progression, migration/invasion and xenograft tumor growth by sponging miR-873-5p, thereby relieving repression of FSTL1 (circ_0058129/miR-873-5p/FSTL1 ceRNA axis)."	0.82
35378711	"Reproductive sciences (Thousand Oaks, Calif.)"	2022	Circ_0005576 Exerts an Oncogenic Role in Cervical Cancer via miR-1305-Dependent Regulation of PAIP1.	hsa_circ_0005576	circ_0005576			Cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ_0005576 is up-regulated in cervical cancer tissues/cells and functions as an oncogenic circRNA. It mainly localizes to the cytoplasm and promotes malignant phenotypes by sponging miR-1305 to increase PAIP1 expression, thereby enhancing tumor growth in vitro and in vivo."	0.8039
35379058	Bioengineered	2022	"Circular RNA circ_0061140 accelerates hypoxia-induced glycolysis, migration, and invasion in lung adenocarcinoma through the microRNA-653/hexokinase 2 (HK2) axis."	hsa_circ_0061140	circ_0061140			lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"circ_0061140 is up-regulated in LUAD tissues/cells (further increased under hypoxia) and promotes hypoxia-induced glycolysis, migration, and invasion. Mechanistically, it sponges miR-653 to de-repress HK2, and high circ_0061140 expression correlates with poorer patient survival."	0.7507
35382824	Journal of translational medicine	2022	Circ_0036412 affects the proliferation and cell cycle of hepatocellular carcinoma via hedgehog signaling pathway.	hsa_circ_0036412		hsa_circ_ETFA	ETFA	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0036412 is up-regulated in HCC cell lines and promotes proliferation while preventing G2/M cell-cycle arrest. Mechanistically, it activates Hedgehog signaling by increasing GLI2 through miR-579-3p sponging and by recruiting ELAVL1 to stabilize GLI2 mRNA; PRDM1 transcriptionally activates circ_0036412 via the ETFA promoter."	0.808
35383130	Aging	2022	Circular RNA_0006014 promotes breast cancer progression through sponging miR-885-3p to regulate NTRK2 and PIK3/AKT pathway.	hsa_circ_0006014	circ_6014 / Circular RNA_0006014	hsa_circ_ILKAP	ILKAP	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"hsa_circ_0006014 (circ_6014), derived from ILKAP, is up-regulated in breast cancer tissues and promotes proliferation, migration/invasion and tumor growth. It functions as a miR-885-3p sponge to upregulate NTRK2 and activate the PIK3CA/AKT pathway, influencing cell-cycle regulators (CDK2/CCNE1 and CDK4/6/CCND1)."	0.7181
35386284	Frontiers in genetics	2022	Identification of lncRNA/circRNA-miRNA-mRNA ceRNA Network as Biomarkers for Hepatocellular Carcinoma.	hsa_circ_0003209				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	dysregulated	Microarray	"hsa_circ_0003209 was identified via microarray datasets and circBank-based prediction as part of a circRNA-miRNA-mRNA ceRNA network in HCC. It is proposed to interact with underexpressed miRNAs and link to cell-cycle/DNA-replication-related mRNAs, showing diagnostic value by ROC analysis."	0.348
35386284	Frontiers in genetics	2022	Identification of lncRNA/circRNA-miRNA-mRNA ceRNA Network as Biomarkers for Hepatocellular Carcinoma.	hsa_circ_0008128				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	dysregulated	Microarray	"hsa_circ_0008128 was predicted as a differentially expressed circRNA in HCC and incorporated into a circRNA-miRNA-mRNA ceRNA network. It showed diagnostic potential by ROC analysis, but lacked experimental (RT-qPCR) validation and prognostic (survival) analysis for circRNAs."	0.348
35386284	Frontiers in genetics	2022	Identification of lncRNA/circRNA-miRNA-mRNA ceRNA Network as Biomarkers for Hepatocellular Carcinoma.	hsa_circ_0020396				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	dysregulated	Microarray	"hsa_circ_0020396 was selected as a differentially expressed circRNA in HCC using microarray datasets and integrated into a predicted circRNA-miRNA-mRNA ceRNA network linking to CDC6/GINS1/MCM genes. It was reported to have diagnostic value by ROC analysis, without wet-lab validation."	0.348
35386284	Frontiers in genetics	2022	Identification of lncRNA/circRNA-miRNA-mRNA ceRNA Network as Biomarkers for Hepatocellular Carcinoma.	hsa_circ_0030051				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	dysregulated	Microarray	hsa_circ_0030051 was included as one of six predicted differentially expressed circRNAs in an HCC ceRNA network (circRNA-miRNA-mRNA) and reported to have diagnostic value via ROC analysis based on microarray datasets.	0.348
35386284	Frontiers in genetics	2022	Identification of lncRNA/circRNA-miRNA-mRNA ceRNA Network as Biomarkers for Hepatocellular Carcinoma.	hsa_circ_0034049				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	dysregulated	Microarray	"hsa_circ_0034049 was computationally identified as a differentially expressed circRNA in HCC and placed into a circRNA-miRNA-mRNA ceRNA network connected to cell-cycle/DNA-replication genes, with reported diagnostic value by ROC analysis."	0.348
35386284	Frontiers in genetics	2022	Identification of lncRNA/circRNA-miRNA-mRNA ceRNA Network as Biomarkers for Hepatocellular Carcinoma.	hsa_circ_0082333				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	dysregulated	Microarray	"hsa_circ_0082333 was identified as a differentially expressed circRNA in HCC via microarray dataset integration and included in a predicted circRNA-miRNA-mRNA ceRNA network. It was reported to have diagnostic value by ROC analysis, with no experimental validation reported."	0.348
35387554	Bioengineered	2022	MM-associated circular RNA downregulates microRNA-19a through methylation to suppress proliferation of pancreatic adenocarcinoma cells.		MM-associated circular RNA (circ-MYBL2) / circ-MYBL2	hsa_circ_MYBL2	MYBL2	pancreatic adenocarcinoma	MONDO:0006047	pancreatic adenocarcinoma	down-regulated	RT-qPCR	"Circ-MYBL2 is downregulated in pancreatic adenocarcinoma tissues and acts as a tumor suppressor in PA cells. Its overexpression reduces proliferation and motility by decreasing miR-19a levels, likely via increased methylation of the miR-19a RNA gene/promoter."	0.6261
35388494	Journal of periodontal research	2022	Identification of potentially functional circRNAs and prediction of circRNA-miRNA-mRNA regulatory network in periodontitis: Bridging the gap between bioinformatics and clinical needs.	hsa_circ_0007364	circPTP4A2	hsa_circ_PTP4A2	PTP4A2	periodontitis	MONDO:0005076	periodontitis	up-regulated	RT-qPCR; RNA-seq	"circPTP4A2 is significantly up-regulated in periodontitis gingival tissues and its expression is positively correlated with probing depth. It shows potential diagnostic utility (ROC) and is included in a predicted circRNA-miRNA-mRNA network suggesting roles in immune/inflammatory processes and other periodontitis-related functions, though the molecular mechanism was not experimentally validated."	0.5963
35388494	Journal of periodontal research	2022	Identification of potentially functional circRNAs and prediction of circRNA-miRNA-mRNA regulatory network in periodontitis: Bridging the gap between bioinformatics and clinical needs.		chr22:23101560_23135351+			periodontitis	MONDO:0005076	periodontitis	up-regulated	RT-qPCR; RNA-seq	"The novel intergenic circRNA chr22:23101560-23135351+ is significantly up-regulated in periodontitis gingival tissues, positively correlates with probing depth, and has the highest diagnostic performance among the five validated circRNAs (ROC AUC 0.8667). It is incorporated into a predicted circRNA-miRNA-mRNA network, but its mechanism and function remain unvalidated experimentally."	0.5963
35388494	Journal of periodontal research	2022	Identification of potentially functional circRNAs and prediction of circRNA-miRNA-mRNA regulatory network in periodontitis: Bridging the gap between bioinformatics and clinical needs.	hsa_circ_0005777	circARHGEF28	hsa_circ_ARHGEF28	ARHGEF28	periodontitis	MONDO:0005076	periodontitis	up-regulated	RT-qPCR; RNA-seq	"circARHGEF28 is significantly up-regulated in periodontitis gingival tissues, correlates positively with probing depth, and shows potential diagnostic value (ROC AUC 0.8244). It is part of a predicted circRNA-miRNA-mRNA network suggesting involvement in immune/inflammatory response and other periodontitis-related biological processes, but specific miRNA/mRNA axes were not experimentally validated."	0.5963
35388494	Journal of periodontal research	2022	Identification of potentially functional circRNAs and prediction of circRNA-miRNA-mRNA regulatory network in periodontitis: Bridging the gap between bioinformatics and clinical needs.	hsa_circ_0002999	circBARD1	hsa_circ_BARD1	BARD1	periodontitis	MONDO:0005076	periodontitis	up-regulated	RT-qPCR; RNA-seq	"circBARD1 is significantly up-regulated in periodontitis gingival tissues and is positively associated with probing depth. It also shows potential diagnostic value (ROC AUC 0.8013) and is included in a predicted circRNA-miRNA-mRNA network, but no specific downstream miRNA/mRNA targets were experimentally validated in this study."	0.5963
35388494	Journal of periodontal research	2022	Identification of potentially functional circRNAs and prediction of circRNA-miRNA-mRNA regulatory network in periodontitis: Bridging the gap between bioinformatics and clinical needs.	hsa_circ_0067582	circRASA2	hsa_circ_RASA2	RASA2	periodontitis	MONDO:0005076	periodontitis	up-regulated	RT-qPCR; RNA-seq	"circRASA2 is significantly up-regulated in periodontitis gingival tissues, correlates positively with probing depth, and shows potential diagnostic value (ROC AUC 0.7731). It is included in a predicted circRNA-miRNA-mRNA network related to immune/inflammatory and other periodontitis-associated processes, without experimental validation of specific molecular targets."	0.5963
35388975	Thoracic cancer	2022	Circ_0020123 plays an oncogenic role in non-small cell lung cancer depending on the regulation of miR-512-3p/CORO1C.	hsa_circ_0020123	circular RNA_0020123 / circ_0020123	hsa_circ_PDZD8	PDZD8	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"Circ_0020123 is up-regulated in NSCLC tissues, serum, and NSCLC cell lines and mainly localizes to the cytoplasm. Functionally, it promotes malignant phenotypes (proliferation, migration/invasion, angiogenesis, and autophagy) and suppresses apoptosis; in vivo knockdown inhibits xenograft growth. Mechanistically, circ_0020123 acts as a ceRNA that sponges miR-512-3p to increase CORO1C expression."	0.8039
35390056	PloS one	2022	"Hsa_circ_0056686, derived from cancer-associated fibroblasts, promotes cell proliferation and suppresses apoptosis in uterine leiomyoma through inhibiting endoplasmic reticulum stress."	hsa_circ_0056686		hsa_circ_KIF5C	KIF5C	uterine leiomyoma / ULM	MONDO:0007886	uterine corpus leiomyoma	up-regulated	RT-qPCR	"In uterine leiomyoma, CAF-derived hsa_circ_0056686 is up-regulated and promotes leiomyoma smooth muscle cell proliferation and migration while suppressing ER stress_induced apoptosis. Mechanistically, it directly binds/sponges miR-515-5p and is linked to altered ER stress markers and ECM-related proteins."	0.7032
35391800	Frontiers in genetics	2022	"Comprehensive Analysis of RNA-Seq in Endometriosis Reveals Competing Endogenous RNA Network Composed of circRNA, lncRNA and mRNA."		circGLIS2	hsa_circ_GLIS2	GLIS2	Endometriosis / EMS	MONDO:0005133	endometriosis	up-regulated	RT-qPCR; RNA-seq	"In endometriosis/EMS ectopic tissues, circGLIS2 is up-regulated and is proposed to act through a ceRNA mechanism by binding hsa-miR-3619-5p to regulate FAM163A expression."	0.4032
35391800	Frontiers in genetics	2022	"Comprehensive Analysis of RNA-Seq in Endometriosis Reveals Competing Endogenous RNA Network Composed of circRNA, lncRNA and mRNA."		circFN1	hsa_circ_FN1	FN1	Endometriosis / EMS	MONDO:0005133	endometriosis	up-regulated	RT-qPCR; RNA-seq	"In EMS ectopic tissues, circFN1 is up-regulated and may function as a ceRNA by sponging hsa-miR-1301-3p to increase CD84, contributing to immune-related dysregulation in endometriosis."	0.4032
35395444	"Clinics (Sao Paulo, Brazil)"	2022	Circ_0075825 promotes gastric cancer progression via adsorbing miR-432-5p to modulate SOX9.	hsa_circ_0075825	Circ_0075825 / circ_ 0075825			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circ_0075825 is up-regulated in gastric cancer tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion) while inhibiting apoptosis. It functions as a ceRNA by sponging miR-432-5p to increase SOX9 expression, with downstream effects including increased CTNNB1 (beta-catenin) and COL10A1."	0.6815
35395674	Cancer research	2022	Aberrant Nuclear Export of circNCOR1 Underlies SMAD7-Mediated Lymph Node Metastasis of Bladder Cancer.	hsa_circ_0042174	circNCOR1	hsa_circ_NCOR1	NCOR1	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"circNCOR1 is downregulated in bladder cancer with lymph node metastasis and acts as a tumor suppressor. In the nucleus, it binds hnRNPL and the SMAD7 promoter to increase p300-dependent H3K9ac, activating SMAD7 transcription and suppressing TGFbeta_SMAD signaling, thereby inhibiting lymphangiogenesis and LN metastasis. SUMO2-K53_modified DDX39B promotes nuclear export of circNCOR1 and weakens this suppressive effect."	0.8994
35395756	BMC cancer	2022	The circular RNA circFARSA sponges microRNA-330-5p in tumor cells with bladder cancer phenotype.			hsa_circ_FARSA	FARSA	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"circFARSA is up-regulated in bladder cancer tissues and cell lines and promotes malignant phenotypes (proliferation, migration/invasion) while inhibiting apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-330-5p, thereby increasing downstream oncogenic proteins such as MAPK/ERK, SIRT6, ITGA5, PAK1, MUC1 and NOB1, and its knockdown suppresses tumor growth in a T24 xenograft model."	0.6837
35396377	Cell death discovery	2022	circ_0004140 promotes LUAD tumor progression and immune resistance through circ_0004140/miR-1184/CCL22 axis.	hsa_circ_0004140	circ_0004140 / circ-0004140	hsa_circ_YAP1	YAP1	Lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"circ_0004140 (derived from YAP1) is up-regulated in LUAD and correlates with poor prognosis. It promotes proliferation, migration/invasion and suppresses apoptosis, and contributes to immune resistance/CTL exhaustion by sponging miR-1184 to upregulate CCL22. Targeting the CCL22/CCR4 axis (C-021) combined with anti-PD-1 reduced xenograft tumor growth and improved survival, suggesting circ_0004140 as a therapeutic target linked to anti-PD-1 resistance."	0.8711
35396504	Cell death & disease	2022	Hsa_circRNA_0088036 acts as a ceRNA to promote bladder cancer progression by sponging miR-140-3p.	hsa_circ_0088036	hsa_circRNA_0088036	hsa_circ_SUSD1	SUSD1	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_0088036 is upregulated in bladder cancer and promotes proliferation, migration, invasion and metastasis. It functions as a ceRNA by sponging miR-140-3p, thereby increasing FOXQ1 expression, and its high expression is associated with worse overall survival and aggressive clinicopathologic features."	0.8486
35396749	Journal of clinical laboratory analysis	2022	Circular RNA hsa_circ_0011298 enhances Taxol resistance of non-small cell lung cancer by regulating miR-486-3p/CRABP2 axis.	hsa_circ_0011298	circ_0011298	hsa_circ_TINAGL1	TINAGL1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"In Taxol-resistant NSCLC, circ_0011298 is upregulated and mainly localized in the cytoplasm. It promotes Taxol resistance by acting as a sponge for miR-486-3p, thereby increasing CRABP2 expression and enhancing proliferation, migration/invasion, and glycolysis while reducing apoptosis and cell-cycle arrest."	0.8443
35396771	Cancer science	2022	Exosomal circGSE1 promotes immune escape of hepatocellular carcinoma by inducing the expansion of regulatory T cells.	hsa_circ_0000722	circGSE1	hsa_circ_GSE1	GSE1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circGSE1 is upregulated in HCC serum exosomes and HCC tissues. HCC-derived exosomal circGSE1 enters T cells, localizes mainly in the cytoplasm, sponges miR-324-5p, and derepresses the TGFBR1/Smad3 pathway to increase FOXP3 and expand Tregs, promoting immune escape and metastasis."	0.786
35396925	Thoracic cancer	2022	Exosomal circDNER enhances paclitaxel resistance and tumorigenicity of lung cancer via targeting miR-139-5p/ITGB8.		circDNER / circ_DNER	hsa_circ_DNER	DNER	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; Microarray	"circDNER is upregulated in lung cancer tissues and plasma exosomes and is further increased in PTX-resistant settings. It promotes malignant phenotypes and paclitaxel resistance by sponging miR-139-5p to increase ITGB8 expression, and exosomal circDNER enhances tumor growth and invasiveness; high circDNER correlates with poor survival."	0.7592
35397013	Discover oncology	2022	Association of has_circ_0001944 upregulations with prognosis and cancer progression in patients with colorectal cancer.	hsa_circ_0001944	circ_0001944	hsa_circ_FIRRE	FIRRE	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"hsa_circ_0001944 is up-regulated in colorectal cancer and high expression predicts worse OS/RFS. Functionally, it promotes CRC cell proliferation, migration and invasion and suppresses apoptosis, at least partly by binding (sponging) miR-548b-3p."	0.7948
35399564	Translational lung cancer research	2022	CircP4HB regulates ferroptosis via SLC7A11-mediated glutathione synthesis in lung adenocarcinoma.	hsa_circ_0046263	circP4HB / circ_0046263	hsa_circ_P4HB	P4HB	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"circP4HB (hsa_circ_0046263), derived from P4HB, is up-regulated in LUAD and functions as a ferroptosis suppressor. It acts as a ceRNA by sponging miR-1184 to increase SLC7A11 (xCT), promoting glutathione synthesis, reducing lipid peroxidation/ROS, and thereby protecting LUAD cells from erastin-induced ferroptosis and promoting tumor growth in xenografts."	0.7876
35400095	Frontiers in veterinary science	2022	"circRNA Expression Pattern and circRNA-miRNA-mRNA Network in HCs, HSCs, and KCs of Murine Liver After Echinococcus multilocularis Infection."	mmu_circ_0000081	mmu-circ-0000081 / circDENND1B	mmu_circ_DENND1B	DENND1B	alveolar echinococcosis	MONDO:0017282	alveolar echinococcosis	up-regulated	RNA-seq	"circDENND1B (mmu-circ-0000081) is reported as significantly up-regulated in hepatocytes of murine liver after E. multilocularis infection, and is implicated in a ceRNA-like interaction with miR-17-5p affecting Abca1-related cholesterol efflux/cholesterol metabolism."	0.1768
35400271	Bioengineered	2022	CircSEC24A (hsa_circ_0003528) interference suppresses epithelial-mesenchymal transition of hepatocellular carcinoma cells via miR-421/MMP3 axis.	hsa_circ_0003528	circSEC24A	hsa_circ_SEC24A	SEC24A	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circSEC24A (hsa_circ_0003528) is up-regulated in HCC and mainly localized in the cytoplasm. It promotes HCC cell proliferation, migration, invasion and EMT by sponging miR-421 and thereby relieving miR-421-mediated repression of MMP3; circSEC24A knockdown suppresses xenograft tumor growth."	0.742
35400275	"Cell cycle (Georgetown, Tex.)"	2022	Circular RNA CircITCH (has-circ-0001141) suppresses hepatocellular carcinoma (HCC) progression by sponging miR-184.	hsa_circ_0001141	CircITCH / circ-0001141	hsa_circ_ITCH	ITCH	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"circITCH (hsa_circ_0001141), derived from ITCH, is down-regulated in HCC cells and mainly localized in the cytoplasm. It suppresses HCC malignant phenotypes (proliferation, migration, invasion) and promotes apoptosis, partly by sponging miR-184; miR-184 rescue attenuates circITCH¡¯s tumor-suppressive effects. In a cell line-derived xenograft model, circITCH overexpression inhibits tumor growth."	0.7637
35400282	Bioengineered	2022	Circle RNA circ_0007331 promotes colorectal carcinoma by targeting miR-205-5p/high-mobility group A2 axis.	hsa_circ_0007331	circ_0007331			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circ_0007331 is up-regulated in colorectal cancer and promotes CRC cell growth, colony formation, migration and invasion, and tumor growth in vivo. Mechanistically, it acts through a circ_0007331/miR-205-5p/HMGA2 ceRNA axis, where circ_0007331 suppresses miR-205-5p to increase HMGA2, contributing to EMT-associated changes."	0.7094
35401927	Oxidative medicine and cellular longevity	2022	"lncRNA ADAMTS9-AS1/circFN1 Competitively Binds to miR-206 to Elevate the Expression of ACTB, Thus Inducing Hypertrophic Cardiomyopathy."		circFN1 / circular RNA FN1	hsa_circ_FN1	FN1	Hypertrophic cardiomyopathy / HCM	MONDO:0005045	hypertrophic cardiomyopathy	down-regulated	RT-qPCR	"In HCM peripheral blood, circFN1 is down-regulated. circFN1 acts as a ceRNA by binding miR-206 (AGO2-associated), thereby relieving miR-206-mediated repression of ACTB and contributing to HCM occurrence/progression."	0.6521
35402068	Molecular therapy. Nucleic acids	2022	The circular RNA circNlgnmediates doxorubicin-inducedcardiac remodeling and fibrosis.			hsa_circ_NLGN	neuroligin	cardiomyopathy	MONDO:0004994	cardiomyopathy	up-regulated	RT-qPCR	"circNlgn is induced by doxorubicin in cardiac cells and hearts and mediates doxorubicin-induced cardiac remodeling/fibrosis and cardiomyocyte injury. Mechanistically, circNlgn encodes Nlgn173, which binds/activates H2AX to increase gammaH2AX and induces a downstream inflammatory/fibrotic program involving IL-1b/IL-2Rb/IL-6 and EGR1/EGR3, with activation of p38 and JNK and upregulation of Gadd45b/Sema4C/RAD50."	0.6973
35402073	Molecular therapy. Nucleic acids	2022	CircHGF suppressed cell proliferation and osteogenic differentiation of BMSCs in ONFH via inhibiting miR-25-3p binding to SMAD7.	hsa_circ_0080914	circHGF	hsa_circ_HGF	HGF	steroid-induced osteonecrosis of the femoral head / SONFH	MONDO:0012126	familial avascular necrosis of femoral head	up-regulated	RT-qPCR; Microarray	"circHGF (hsa_circ_0080914), derived from HGF, is up-regulated in BMSCs from steroid-induced ONFH patients. It suppresses BMSC proliferation and osteogenic differentiation by sponging miR-25-3p, thereby relieving miR-25-3p repression of SMAD7 (circHGF/miR-25-3p/SMAD7 axis)."	0.788
35406411	Cancers	2022	Targeting circDGKD Intercepts TKI's Effects on Up-Regulation of Estrogen Receptor beta and Vasculogenic Mimicry in Renal Cell Carcinoma.	hsa_circ_0058763	circDGKD	hsa_circ_DGKD	DGKD	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR	"In RCC, TKI-induced ERbeta transcriptionally elevates circDGKD (DGKD-derived). circDGKD sponges miR-125a-5p/miR-125b-5p to increase VE-cadherin (CDH5), thereby promoting vasculogenic mimicry and metastasis; circDGKD silencing blocks these effects and improves survival in an orthotopic model."	0.8294
35411716	Thoracic cancer	2022	Identification of a novel circ_0001946/miR-1290/SOX6 ceRNA network in esophageal squamous cell cancer.	hsa_circ_0001946	circ_0001946	hsa_circ_CDR1	CDR1	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	RT-qPCR	"circ_0001946 is down-regulated in ESCC tissues and ESCC cell lines. Its overexpression suppresses proliferation, invasion and migration, promotes apoptosis, and inhibits xenograft tumor growth by sponging miR-1290 to relieve miR-1290-mediated repression of SOX6 (circ_0001946/miR-1290/SOX6 ceRNA axis)."	0.8172
35412941	Bioengineered	2022	Circular RNA circ_0004277 Inhibits Acute Myeloid Leukemia Progression Through MicroRNA-134-5p / Single stranded DNA binding protein 2.	hsa_circ_0004277	circ_0004277			acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	down-regulated	RT-qPCR; Microarray	"circ_0004277 is down-regulated in AML bone marrow samples and AML cell lines. It functions as a tumor suppressor by sponging miR-134-5p to de-repress/up-regulate SSBP2, thereby inhibiting AML cell viability, migration and invasion."	0.8035
35412955	Bioengineered	2022	Circular RNA Eps15-homology domain-containing protein 2 induce resistance of renal cell carcinoma to sunitinib via microRNA-4731-5p/ABCF2 axis.		circEHD2	hsa_circ_EHD2	EHD2	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR	"circEHD2 is up-regulated in sunitinib-resistant RCC tissues/cells and promotes sunitinib resistance and malignant phenotypes. Mechanistically, circEHD2 sponges miR-4731-5p to increase ABCF2, and ABCF2 overexpression counteracts the effects of circEHD2 knockdown."	0.7945
35415017	PeerJ	2022	The regulation of hsacirc_004413 promotes proliferation and drug resistance of gastric cancer cells by acting as a competing endogenous RNA for miR-145-5p.	hsa_circ_0004650	hsacirc_004413			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"hsacirc_004413 (hsa_circ_0004650) is up-regulated in 5-Fu-resistant gastric cancer cells and promotes proliferation and 5-Fu chemoresistance. Its knockdown increases apoptosis/necrosis and restores 5-Fu sensitivity, likely by sponging miR-145-5p."	0.4469
35415236	Open life sciences	2022	"circ-CFH promotes the development of HCC by regulating cell proliferation, apoptosis, migration, invasion, and glycolysis through the miR-377-3p/RNF38 axis."	hsa_circ_0015756	circ-CFH / circ_0015756	hsa_circ_CFH	CFH	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ-CFH is up-regulated in HCC tissues/cells and promotes malignant phenotypes (proliferation, migration, invasion, glycolysis) while inhibiting apoptosis. It functions mainly as a ceRNA sponge for miR-377-3p, thereby increasing RNF38 expression and accelerating HCC progression; circ-CFH silencing suppresses xenograft tumor growth."	0.7045
35416113	Renal failure	2022	Inhibition of Circ-Snrk ameliorates apoptosis and inflammation in acute kidney injury by regulating the MAPK pathway.		circ-Snrk / Rno-circ-Snrk	rno_circ_SNRK	SNRK	acute kidney injury / AKI	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR	"Circ-Snrk is up-regulated in I/R-induced AKI rat kidney tissue and in H/R-treated NRK-52E cells. Silencing circ-Snrk reduces apoptosis and inflammatory cytokine secretion and alleviates kidney injury, at least partly by inhibiting MAPK pathway activation (reduced p38/JNK/ERK phosphorylation)."	0.6742
35418175	Scientific reports	2022	The upregulation of circFNDC3B aggravates the recurrence after endoscopic submucosal dissection (ESD) in early gastric cancer (EGC) patients.		circFNDC3B	hsa_circ_FNDC3B	FNDC3B	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circFNDC3B is upregulated in the high-expression EGC patient group after ESD and is associated with a lower recurrence-free rate. Mechanistically, it sponges miR-942 and miR-510 to increase CD44 and CDH1 expression, supporting its potential use as a recurrence-risk biomarker."	0.7083
35419056	Journal of oncology	2022	CircINTS4 Facilitates Chemoresistance of TNBC by Competitively Binding miR-129-5p/POM121 Axis.		circINTS4	hsa_circ_INTS4	INTS4	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"circINTS4 is up-regulated in ADR-resistant TNBC cells and promotes chemoresistance-related malignant phenotypes (proliferation, migration/invasion, autophagy) and tumor growth. Mechanistically, it functions as a ceRNA by sponging miR-129-5p to up-regulate POM121."	0.6306
35419455	BioMed research international	2022	Identification of Key CircRNAs Related to Pulmonary Tuberculosis Based on Bioinformatics Analysis.	hsa_circ_0007919				pulmonary tuberculosis / TB	MONDO:0006052	pulmonary tuberculosis	up-regulated	RNA-seq	hsa_circ_0007919 was identified by circRNA-seq differential expression plus machine-learning/univariate feature selection as a hub circRNA associated with pulmonary tuberculosis and is up-regulated in diseased lung tissues. The study mainly provides a diagnostic-marker candidate signal without experimental mechanistic validation for this circRNA.	0.1768
35419455	BioMed research international	2022	Identification of Key CircRNAs Related to Pulmonary Tuberculosis Based on Bioinformatics Analysis.	hsa_circ_0002419				pulmonary tuberculosis / TB	MONDO:0006052	pulmonary tuberculosis	down-regulated	RNA-seq	"hsa_circ_0002419 was identified as a hub circRNA associated with pulmonary tuberculosis using circRNA-seq differential expression and machine-learning/univariate analyses, and it is down-regulated in diseased lung tissues. No direct mechanistic axis or wet-lab validation was provided for this circRNA in the study."	0.1768
35419455	BioMed research international	2022	Identification of Key CircRNAs Related to Pulmonary Tuberculosis Based on Bioinformatics Analysis.	hsa_circ_0005521				pulmonary tuberculosis / TB	MONDO:0006052	pulmonary tuberculosis	down-regulated	RNA-seq	hsa_circ_0005521 was identified as a down-regulated hub circRNA in pulmonary tuberculosis lung tissues by circRNA-seq plus machine-learning/univariate analyses. The study proposes a ceRNA-type regulatory relationship where hsa_circ_0005521 is upstream of hsa-miR-409-5p and is linked to 16 overlapping downstream mRNAs via bioinformatics network construction and enrichment analyses.	0.2465
35421275	Journal of clinical laboratory analysis	2022	Circulating cell-free circRNA panel predicted tumorigenesis and development of colorectal cancer.		hsa_circ_001978			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_001978 is up-regulated in CRC patient plasma compared with CRA and healthy controls and, together with hsa_circ_105039 and hsa_circ_103627, forms a circulating circRNA diagnostic panel with strong ROC performance for distinguishing CRC from non-cancer groups. No CRC-related molecular mechanism was experimentally investigated in this study."	0.5963
35421275	Journal of clinical laboratory analysis	2022	Circulating cell-free circRNA panel predicted tumorigenesis and development of colorectal cancer.		hsa_circ_105039 / circRNA_105039			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	hsa_circ_105039 is increased in CRC plasma and is part of a three-circRNA circulating panel that distinguishes CRC from CRA and healthy controls with high AUC. The study did not experimentally define its CRC mechanism.	0.5963
35421275	Journal of clinical laboratory analysis	2022	Circulating cell-free circRNA panel predicted tumorigenesis and development of colorectal cancer.		hsa_circ_103627			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	hsa_circ_103627 is up-regulated in CRC plasma and contributes to a three-circRNA circulating panel with strong diagnostic performance for early CRC detection against CRA and healthy controls. The study focused on biomarker performance and stability rather than mechanistic validation.	0.5963
35422846	Frontiers in genetics	2022	Construction and Bioinformatics Analysis of circRNA-miRNA-mRNA Network in Acute Myocardial Infarction.	hsa_circ_0031017		hsa_circ_TMCO3	TMCO3	acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR; Microarray	"hsa_circ_0031017 is up-regulated in AMI and was validated by qRT-PCR. It is proposed to act in a ceRNA axis by binding hsa-miR-142-5p to affect PTEN expression, linking the circRNA network to AMI-related processes such as autophagy/apoptosis."	0.5922
35422846	Frontiers in genetics	2022	Construction and Bioinformatics Analysis of circRNA-miRNA-mRNA Network in Acute Myocardial Infarction.	hsa_circ_0030569		hsa_circ_ABCC4	ABCC4	acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR; Microarray	"hsa_circ_0030569 is up-regulated in AMI and was validated by qRT-PCR. It is proposed to participate in a ceRNA axis by binding hsa-miR-545, thereby influencing PTGS2 expression and inflammation-related MI injury."	0.5922
35422846	Frontiers in genetics	2022	Construction and Bioinformatics Analysis of circRNA-miRNA-mRNA Network in Acute Myocardial Infarction.	hsa_circ_0009018		hsa_circ_EXT2	EXT2	acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR; Microarray	"hsa_circ_0009018 is up-regulated in AMI and was validated by qRT-PCR. It is proposed to act as a ceRNA by binding hsa-miR-139-3p to modulate BCL6, linking the circRNA network to cardiomyocyte hypoxia injury-related responses."	0.5922
35431783	Frontiers in neuroscience	2022	Peripheral Blood Circular RNAs as a Biomarker for Major Depressive Disorder and Prediction of Possible Pathways.	hsa_circ_0002473		hsa_circ_DNAJC3	DNAJC3	major depressive disorder / MDD	MONDO:0002009	major depressive disorder	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0002473 is up-regulated in peripheral blood of MDD patients and shows diagnostic potential by ROC analysis. Unlike the other verified circRNAs, it was reported to have no ceRNA relationship pair in the constructed network."	0.5047
35431783	Frontiers in neuroscience	2022	Peripheral Blood Circular RNAs as a Biomarker for Major Depressive Disorder and Prediction of Possible Pathways.	hsa_circ_0079651		hsa_circ_HNRNPA2B1	HNRNPA2B1	major depressive disorder / MDD	MONDO:0002009	major depressive disorder	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0079651 is up-regulated in peripheral blood of MDD patients and shows diagnostic value by ROC analysis. Bioinformatics-based ceRNA network analysis suggests it may influence MDD-related neuroplasticity via circRNA_miRNA_mRNA regulation.	0.5047
35431783	Frontiers in neuroscience	2022	Peripheral Blood Circular RNAs as a Biomarker for Major Depressive Disorder and Prediction of Possible Pathways.	hsa_circ_0137187	circZFAND1	hsa_circ_ZFAND1	ZFAND1	major depressive disorder / MDD	MONDO:0002009	major depressive disorder	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0137187 (also referred to as circZFAND1) is up-regulated in peripheral blood of MDD patients and shows diagnostic value by ROC analysis. Bioinformatics-based ceRNA network analysis suggests it may affect MDD-related neuroplasticity via circRNA_miRNA_mRNA regulation.	0.5047
35431783	Frontiers in neuroscience	2022	Peripheral Blood Circular RNAs as a Biomarker for Major Depressive Disorder and Prediction of Possible Pathways.	hsa_circ_0006010	circDPY19L1P1	hsa_circ_DPY19L1P1	DPY19L1P1	major depressive disorder / MDD	MONDO:0002009	major depressive disorder	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0006010 (also referred to as circDPY19L1P1) is up-regulated in peripheral blood of MDD patients and has diagnostic value (ROC AUC reported). Bioinformatics analysis suggests it may contribute to MDD-related neuroplasticity via a predicted ceRNA network.	0.5047
35431783	Frontiers in neuroscience	2022	Peripheral Blood Circular RNAs as a Biomarker for Major Depressive Disorder and Prediction of Possible Pathways.	hsa_circ_0113010	circEPB41	hsa_circ_EPB41	EPB41	major depressive disorder / MDD	MONDO:0002009	major depressive disorder	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0113010 (also referred to as circEPB41) is up-regulated in peripheral blood of MDD patients and shows diagnostic potential by ROC analysis. Bioinformatics analysis suggests it may be involved in MDD neuroplasticity through a predicted ceRNA mechanism.	0.5047
35434335	Laryngoscope investigative otolaryngology	2022	Downregulation of circLPAR3 inhibits tumor progression and glycolysis by liberating miR-144-3p and upregulating LPCAT1 in oral squamous cell carcinoma.	hsa_circ_0004390	circLPAR3	hsa_circ_LPAR3	LPAR3	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circLPAR3 is up-regulated in OSCC and mainly localized in the cytoplasm. It promotes OSCC progression and glycolysis by acting as a ceRNA that sponges miR-144-3p, thereby upregulating LPCAT1; high circLPAR3 expression has diagnostic value and predicts poor prognosis."	0.8659
35435110	Bioengineered	2022	Circular RNA 0001823 aggravates the growth and metastasis of the cervical cancer cells through modulating the microRNA-613/RAB8A axis.	hsa_circ_0001823	Circular RNA 0001823 / circ_0001823			cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ_0001823 is up-regulated in cervical cancer tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion). Mechanistically, it sponges miR-613 to relieve repression of RAB8A, forming a circ_0001823/miR-613/RAB8A regulatory axis."	0.7911
35435117	Bioengineered	2022	Astragaloside IV exhibits anti-tumor function in gastric cancer via targeting circRNA dihydrolipoamide S-succinyltransferase (circDLST)/miR-489-3p/ eukaryotic translation initiation factor 4A1(EIF4A1) pathway.		circRNA dihydrolipoamide S-succinyltransferase (circDLST) / circDLST	hsa_circ_DLST	DLST	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circDLST is up-regulated in gastric cancer cells and promotes malignant phenotypes. AS-IV suppresses GC proliferation and metastasis partly by downregulating circDLST, which sponges miR-489-3p to increase EIF4A1 expression (circDLST/miR-489-3p/EIF4A1 ceRNA axis)."	0.7092
35435120	Bioengineered	2022	CircSETD3 (hsa_circ_0000567) inhibits proliferation and induces apoptosis in cholangiocarcinoma cells via downregulation of microRNA-421 expression.	hsa_circ_0000567	CircSETD3	hsa_circ_SETD3	SETD3	Cholangiocarcinoma / CCA	MONDO:0019087	cholangiocarcinoma	down-regulated	RT-qPCR	"CircSETD3 (hsa_circ_0000567) is down-regulated in cholangiocarcinoma tissues and cell lines. Its overexpression suppresses proliferation and promotes apoptosis, at least partly by negatively regulating miR-421 and affecting the miR-421/BMF axis."	0.6479
35435123	Bioengineered	2022	CircRNA CTNNB1 (circCTNNB1) ameliorates cerebral ischemia/reperfusion injury by sponging miR-96-5p to up-regulate scavenger receptor class B type 1 (SRB1) expression.		circRNA catenin beta 1 (circCTNNB1) / circCTNNB1	mmu_circ_CTNNB1	CTNNB1	cerebral ischemia-reperfusion injury	MONDO:0005203	ischemia reperfusion injury	down-regulated	RT-qPCR	"circCTNNB1 is down-regulated in OGD/R-treated mouse astrocytes and in MCAO mouse brains. Its overexpression protects against cerebral ischemia/reperfusion injury by acting as a miR-96-5p sponge to increase SRB1 expression, thereby reducing apoptosis, oxidative stress, and inflammatory responses."	0.5309
35435126	Bioengineered	2022	Plasmacytoma variant translocation 1 stabilized by EIF4A3 promoted malignant biological behaviors of lung adenocarcinoma by generating circular RNA LMNB2.	hsa_circ_0048409	circLMNB2	hsa_circ_LMNB2	LMNB2	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"circLMNB2 is up-regulated in LUAD and functions as an oncogenic circRNA that promotes LUAD cell proliferation, migration and invasion. Mechanistically, PVT1 recruits the RBP EIF4A3 to facilitate circLMNB2 generation/expression, and circLMNB2 overexpression rescues the inhibitory phenotypes caused by PVT1/EIF4A3 knockdown. High circLMNB2 is associated with diagnostic value and poorer survival in LUAD."	0.7617
35435136	Bioengineered	2022	Circular RNA circ_0067741 regulates the Hippo/YAP pathway to suppress lung adenocarcinoma progression by targeting microRNA-183-5p.	hsa_circ_0067741	circ_0067741			lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR	"circ_0067741 is down-regulated in LUAD tissues and cell lines and functions as a tumor suppressor. It sponges miR-183-5p to increase LATS1, thereby activating Hippo/YAP signaling (increasing p-YAP and reducing YAP/TAZ activity) and inhibiting malignant phenotypes."	0.6542
35436983	Cell death & disease	2022	circFAM120B functions as a tumor suppressor in esophageal squamous cell carcinoma via the miR-661/PPM1L axis and the PKR/p38 MAPK/EMT pathway.	hsa_circ_0001666	circFAM120B	hsa_circ_FAM120B	FAM120B	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	"circFAM120B (hsa_circ_0001666) is down-regulated in ESCC tissues and patient plasma and higher expression indicates better overall survival. It suppresses ESCC proliferation/migration/invasion/metastasis by sponging miR-661 to restore PPM1L expression and by binding PKR to promote its ubiquitin/proteasome-dependent degradation, thereby inhibiting p38 MAPK signaling and EMT."	0.9018
35437351	International journal of general medicine	2022	Construction of a circRNA-Mediated ceRNA Network Reveals Novel Biomarkers for Aortic Dissection.		hsa_circRNA_082317	hsa_circ_UBE2H	UBE2H	aortic dissection / AD	MONDO:0022470	aortic dissection lentiginosis	up-regulated	RT-qPCR; Microarray	"In aortic dissection, hsa_circRNA_082317 (from UBE2H) is up-regulated and is proposed to act as a ceRNA by sponging hsa-miR-149-3p, thereby increasing ITGA5 (and other targets) and relating to ECM_receptor interaction and focal adhesion pathways. It was identified from GEO microarray data and validated by qRT-PCR in plasma from AD patients."	0.5135
35439733	Aging	2022	Circular RNA circ_0000423 regulates cartilage ECM synthesis via circ_0000423/miRNA-27b-3p/MMP-13 axis in osteoarthritis.	hsa_circ_0000423				osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; Microarray	"circ_0000423 is up-regulated in OA cartilage and IL-1beta-induced chondrocytes. It sponges miRNA-27b-3p to regulate MMP-13 and collagen II (COL-2), promoting ECM degradation and OA progression. In vivo, AAV-shRNA-mediated silencing of circ_0000423 alleviates cartilage destruction and reduces subchondral bone resorption in ACLT-induced OA mice."	0.7968
35440286	Bioengineered	2022	CircRNA circ_0023984 promotes the progression of esophageal squamous cell carcinoma via regulating miR-134-5p/cystatin-s axis.	hsa_circ_0023984	circ_0023984 / circRNA_0023984	hsa_circ_NOX4	NOX4	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"circ_0023984 is up-regulated in ESCC tissues/cell lines and acts as an oncogenic circRNA. It mainly localizes to the cytoplasm and sponges miR-134-5p, thereby de-repressing CST4 to promote ESCC proliferation, migration/invasion, and xenograft tumor growth; high expression correlates with worse overall survival."	0.8489
35441564	Bioengineered	2022	"CircMYC promotes proliferation, migration, invasion and inhibits apoptosis of small cell lung cancer by targeting miR-145/ Matrix Metallopeptidase 2 axis."	hsa_circ_0085533	circMYC	hsa_circ_MYC	MYC	small cell lung cancer / SCLC	MONDO:0008433	small cell lung carcinoma	up-regulated	RT-qPCR	"circMYC is up-regulated in SCLC tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion) while inhibiting apoptosis. Mechanistically, circMYC is mainly cytoplasmic and acts as a ceRNA that sponges miR-145 to de-repress MMP2, forming a circMYC/miR-145/MMP2 axis associated with poor prognosis."	0.817
35443871	Bioengineered	2022	circHIPK3 regulates cell proliferation and migration by sponging microRNA-124 and regulating serine/threonine kinase 3 expression in esophageal squamous cell carcinoma.		circHIPK3	hsa_circ_HIPK3	HIPK3	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; ISH	"circHIPK3 is upregulated in ESCC tissues and cell lines and its high expression is associated with poor prognosis and aggressive clinicopathologic features. Functionally, circHIPK3 promotes ESCC proliferation, migration and EMT, at least in part by sponging miR-124 to increase AKT3 expression, and its knockdown suppresses xenograft growth."	0.8324
35444525	Frontiers in aging neuroscience	2022	Characterization of circRNA-Associated-ceRNA Networks Involved in the Pathogenesis of Postoperative Cognitive Dysfunction in Aging Mice.		mm9_circ_009789			postoperative cognitive dysfunction / POCD	MONDO:0002602	central nervous system disorder	up-regulated	RT-qPCR; RNA-seq	"In an aging mouse POCD model, mm9_circ_009789 is up-regulated in hippocampus after anesthesia/surgery and participates in a ceRNA network by binding mmu-miR-298-5p. This network is suggested to affect downstream targets (e.g., Prkcb, Zbtb4, Syngap1) and is linked to PKC signaling, apoptosis, and glycolipid metabolism, with additional association to Wnt-related inflammatory processes."	0.6578
35444525	Frontiers in aging neuroscience	2022	Characterization of circRNA-Associated-ceRNA Networks Involved in the Pathogenesis of Postoperative Cognitive Dysfunction in Aging Mice.		mm9_circ_004229			postoperative cognitive dysfunction / POCD	MONDO:0002602	central nervous system disorder	up-regulated	RT-qPCR; RNA-seq	"In an aging mouse POCD model, mm9_circ_004229 is up-regulated in hippocampus after anesthesia/surgery and binds mmu-miR-298-5p (ceRNA mechanism). It is implicated in regulating downstream genes such as Prkcb, Zbtb4 and Syngap1 and is linked to PKC signaling, apoptosis, and glycolipid metabolism, with predicted involvement in VEGF-related pathways via Sulf1."	0.6578
35444525	Frontiers in aging neuroscience	2022	Characterization of circRNA-Associated-ceRNA Networks Involved in the Pathogenesis of Postoperative Cognitive Dysfunction in Aging Mice.		mm9_circ_003736			postoperative cognitive dysfunction / POCD	MONDO:0002602	central nervous system disorder	down-regulated	RT-qPCR; RNA-seq	"mm9_circ_003736 is down-regulated in aging mice under control conditions and is part of predicted ceRNA networks involving several miRNAs. Although its expression is stated to be not changed by anesthesia/surgery, its anesthesia/surgery-associated network is suggested to involve mRNAs linked to learning and synaptic functions, implying a possible relationship to POCD occurrence."	0.5202
35444650	Frontiers in immunology	2022	N6-Methyladenosine-Modified circRNA in the Bovine Mammary Epithelial Cells Injured by Staphylococcus aureus and Escherichia coli.		circRNA_OPA3	bta_circ_OPA3	OPA3	mastitis	MONDO:0006849	mastitis	unknown	RNA-seq	"circRNA_OPA3 is reported as a differentially m6A-hypermethylated circRNA in MAC-T cells after S. aureus treatment, suggesting a potential involvement in bacteria-induced cell injury. Its downstream miRNA/mRNA targets are not specified for this circRNA in the provided text."	0.3816
35444650	Frontiers in immunology	2022	N6-Methyladenosine-Modified circRNA in the Bovine Mammary Epithelial Cells Injured by Staphylococcus aureus and Escherichia coli.		circRNA_AKT3	bta_circ_AKT3	AKT3	mastitis	MONDO:0006849	mastitis	unknown	RNA-seq	"circRNA_AKT3 is identified as a differentially m6A-hypomethylated circRNA in MAC-T cells after S. aureus treatment, implicating it in bacteria-induced cell injury. Specific miRNA/mRNA regulatory relationships for this circRNA are not provided in the excerpt."	0.3816
35444650	Frontiers in immunology	2022	N6-Methyladenosine-Modified circRNA in the Bovine Mammary Epithelial Cells Injured by Staphylococcus aureus and Escherichia coli.		circRNA_GRB10	bta_circ_GRB10	GRB10	mastitis	MONDO:0006849	mastitis	unknown	RNA-seq	"circRNA_GRB10 is identified as a differentially m6A-hypermethylated circRNA in MAC-T cells after E. coli treatment, suggesting potential involvement in bacteria-induced cell injury relevant to mastitis. No specific downstream miRNA/mRNA interactions are provided for this circRNA in the excerpt."	0.3816
35444650	Frontiers in immunology	2022	N6-Methyladenosine-Modified circRNA in the Bovine Mammary Epithelial Cells Injured by Staphylococcus aureus and Escherichia coli.		circRNA_SMAD1	bta_circ_SMAD1	SMAD1	mastitis	MONDO:0006849	mastitis	unknown	RNA-seq	circRNA_SMAD1 is identified as a differentially m6A-hypomethylated circRNA in MAC-T cells under E. coli stimulation. The study suggests m6A-modified circRNAs (including this one) may influence mastitis-related cell injury via predicted circRNA_miRNA_mRNA networks affecting immune/inflammation and apoptosis-related pathways.	0.3816
35445786	Thoracic cancer	2022	Downregulation of circATXN7 represses non-small cell lung cancer growth by releasing miR-7-5p.	hsa_circ_0066436	circATXN7 / hsa_circATXN7_010	hsa_circ_ATXN7	ATXN7	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circATXN7 is up-regulated in NSCLC tissues and cell lines and mainly localizes to the cytoplasm. It promotes NSCLC proliferation, invasion/metastasis and EMT while inhibiting apoptosis, partly by sponging miR-7-5p to de-repress PFN2; circATXN7 knockdown suppresses xenograft tumor growth."	0.8039
35446993	Journal of clinical laboratory analysis	2022	"Exosomal circular RNA hsa_circ_0006220, and hsa_circ_0001666 as biomarkers in the diagnosis of pancreatic cancer."	hsa_circ_0006220				pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; Microarray	"hsa_circ_0006220 is up-regulated in pancreatic cancer, including in patient plasma exosomes, and shows diagnostic value (ROC AUC ~0.78). Its plasma exosomal level is associated with CA19-9 positivity and lymph node metastasis."	0.5047
35446993	Journal of clinical laboratory analysis	2022	"Exosomal circular RNA hsa_circ_0006220, and hsa_circ_0001666 as biomarkers in the diagnosis of pancreatic cancer."	hsa_circ_0001666				pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; Microarray	hsa_circ_0001666 is up-regulated in pancreatic cancer patient plasma exosomes and has diagnostic value (ROC AUC ~0.81). Its exosomal level correlates with tumor size and CA19-9 level.	0.5047
35447001	Journal of clinical laboratory analysis	2022	hsa_circ_0000285 facilitates thyroid cancer progression by regulating miR-127-5p/CDH2.	hsa_circ_0000285	circ_0000285			thyroid cancer / TC	MONDO:0002108	thyroid cancer	up-regulated	RT-qPCR	"hsa_circ_0000285 is up-regulated in THCA tissues/cells and promotes malignant phenotypes (proliferation, migration, tumor growth) while inhibiting apoptosis. It functions mainly in the cytoplasm as a ceRNA sponging miR-127-5p, thereby increasing CDH2 expression."	0.7785
35453537	Biomedicines	2022	Retinal Circular RNA hsa_circ_0087207 Expression Promotes Apoptotic Cell Death in Induced Pluripotent Stem Cell-Derived Leber's Hereditary Optic Neuropathy-like Models.	hsa_circ_0087207		hsa_circ_ALDH1A1	ALDH1A1	Leber¡¯s hereditary optic neuropathy / LHON	MONDO:0010788	Leber hereditary optic neuropathy	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0087207 is up-regulated in LHON patient iPSC-derived retinal ganglion cells and promotes apoptotic cell death. Mechanistically, it is predicted to act as a miR-665 sponge, thereby increasing expression programs related to DNA damage/repair and apoptosis."	0.6475
35458413	Viruses	2022	Circular RNA Profiles in Viremia and ART Suppression Predict Competing circRNA-miRNA-mRNA Networks Exclusive to HIV-1 Viremic Patients.		hsa-SATB1_AS1_0002 / circSATB1-as	hsa_circ_SATB1_AS1	SATB1	HIV-1 infection	MONDO:0005109	HIV infectious disease	up-regulated	RNA-seq	"circSATB1-as (hsa-SATB1_AS1_0002) was identified as significantly up-regulated in viremic (pre-ART) patients versus post-ART suppression. The study predicts it participates in a circRNA_miRNA_mRNA competing network and may act as an RNA silencing suppressor by sequestering miRNAs (e.g., miR-125b), potentially favoring HIV-1 propagation; it is proposed as a possible biomarker of productively infected/viremic state."	0.1768
35458413	Viruses	2022	Circular RNA Profiles in Viremia and ART Suppression Predict Competing circRNA-miRNA-mRNA Networks Exclusive to HIV-1 Viremic Patients.		circANKRD17 / hsa-ANKRD17_0008	hsa_circ_ANKRD17	ANKRD17	HIV-1 infection	MONDO:0005109	HIV infectious disease	up-regulated	RNA-seq	circANKRD17 (hsa-ANKRD17_0008) was detected in all viremic (pre-ART) patients and became undetectable in post-ART patients. It was included in predicted circRNA_miRNA_mRNA competing networks (with several predicted miRNA response elements) that may influence HIV-1-related host/viral post-transcriptional regulation.	0.1768
35458413	Viruses	2022	Circular RNA Profiles in Viremia and ART Suppression Predict Competing circRNA-miRNA-mRNA Networks Exclusive to HIV-1 Viremic Patients.		hsa-HIPK3_0001 / circHIPK3	hsa_circ_HIPK3	HIPK3	HIV-1 infection	MONDO:0005109	HIV infectious disease	up-regulated	RNA-seq	"circHIPK3 (hsa-HIPK3_0001) was present in all viremic patients and not detectable after ART suppression. The study predicts circHIPK3 participates in competing endogenous circRNA_miRNA_mRNA networks and may sequester miRNAs such as miR-150, potentially facilitating HIV-1 propagation (hypothesis requiring experimental validation)."	0.1768
35458413	Viruses	2022	Circular RNA Profiles in Viremia and ART Suppression Predict Competing circRNA-miRNA-mRNA Networks Exclusive to HIV-1 Viremic Patients.		hsa-PHC3_0020 / circPHC3	hsa_circ_PHC3	PHC3	HIV-1 infection	MONDO:0005109	HIV infectious disease	up-regulated	RNA-seq	"circPHC3 (hsa-PHC3_0020) was detected in all viremic (pre-ART) patients and became undetectable after ART suppression. It carried predicted miRNA response elements (e.g., miR-141-5p, miR-197-3p) and was used to build predicted circRNA_miRNA_mRNA competing networks potentially relevant to HIV-1 viremic status."	0.1768
35458413	Viruses	2022	Circular RNA Profiles in Viremia and ART Suppression Predict Competing circRNA-miRNA-mRNA Networks Exclusive to HIV-1 Viremic Patients.			hsa_circ_ZNF609	ZNF609	HIV-1 infection	MONDO:0005109	HIV infectious disease	up-regulated	RNA-seq	"circZNF609 (hsa-ZNF609_0001) was detected in all viremic (pre-ART) patients and became undetectable after ART suppression. It was assigned predicted miRNA response elements (e.g., miR-26b-3p, miR-149-5p) and incorporated into predicted circRNA_miRNA_mRNA competing networks related to viremic status."	0.1768
35459186	Journal of experimental & clinical cancer research : CR	2022	Circular RNA circ-MTHFD1L induces HR repair to promote gemcitabine resistance via the miR-615-3p/RPN6 axis in pancreatic ductal adenocarcinoma.	hsa_circ_0078297	circ-MTHFD1L / circMTHFD1L	hsa_circ_MTHFD1L	MTHFD1L	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circ-MTHFD1L (hsa_circ_0078297) is up-regulated in PDAC tissues and gemcitabine-resistant PDAC cells and is mainly cytoplasmic. It promotes gemcitabine resistance by sponging miR-615-3p to upregulate RPN6, enhancing cell cycle progression and homologous recombination-related DNA damage repair, and high circ-MTHFD1L expression correlates with worse OS/PFS."	0.8478
35459923	Scientific reports	2022	Transcriptome analysis of fasudil treatment in the APPswe/PSEN1dE9 transgenic (APP/PS1) mice model of Alzheimer's disease.	mmu_circ_0005875	circ_0005875	mmu_circ_Pank2	Pank2	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR; RNA-seq	"mmu_circ_0005875 (from Pank2) is a fasudil-responsive circRNA in APP/PS1 AD-model mouse hippocampus, validated by RT-qPCR. It participates in a mmu-miR-3065-5p-mediated ceRNA network and is positively correlated with Hinfp expression."	0.5079
35466313	Journal of oncology	2022	Upregulated Circular RNA KIF4A Promotes Cell Migration and Invasion by Regulating MicroRNA-144-3p/EZH2 Axis in Gastric Cancer.	hsa_circ_0007255	circKIF4A	hsa_circ_KIF4A	KIF4A	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circKIF4A is up-regulated in gastric cancer and promotes proliferation, migration, invasion, and EMT. It mainly localizes to the cytoplasm and acts as a ceRNA by sponging miR-144-3p to increase EZH2, and higher circKIF4A expression is associated with poorer overall survival."	0.7325
35467477	Drug delivery	2022	Exosome-transmitted circVMP1 facilitates the progression and cisplatin resistance of non-small cell lung cancer by targeting miR-524-5p-METTL3/SOX2 axis.	hsa_circ_0005077	circVMP1 / circRNA vacuole membrane protein 1 (circVMP1)	hsa_circ_VMP1	VMP1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circVMP1 is up-regulated in cisplatin-resistant NSCLC cells and serum exosomes from DDP-resistant patients. It promotes malignant phenotypes and cisplatin resistance by sponging miR-524-5p to increase METTL3 and SOX2 (including METTL3-mediated m6A and SOX2 stability), and can be transferred via exosomes to confer resistance to sensitive cells."	0.8785
35473752	Journal of experimental & clinical cancer research : CR	2022	HIF1alpha-SP1 interaction disrupts the circ-0001875/miR-31-5p/SP1 regulatory loop under a hypoxic microenvironment and promotes non-small cell lung cancer progression.	hsa_circ_0001875	circ-0001875 / circ_0001875	hsa_circ_FAM120A	FAM120A	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ-0001875 is up-regulated in NSCLC and acts as an oncogenic circRNA promoting proliferation, migration/invasion, metastasis, EMT and filopodia formation. It functions as a ceRNA by sponging miR-31-5p to upregulate SP1 and activate EMT-related TGFbeta/Smad2 signaling, while SP1 feeds back to inhibit circ-0001875 biogenesis via AluSq binding; hypoxia-induced HIF1alpha-SP1 interaction relieves this suppression."	0.8912
35474040	Cell death discovery	2022	Molecular mechanism of m6A methylation of circDLC1 mediated by RNA methyltransferase METTL3 in the malignant proliferation of glioma cells.		circDLC1 / circular RNA DLC1	hsa_circ_DLC1	DLC1	glioma	MONDO:0021042	glioma	down-regulated	RT-qPCR	"In glioma, circDLC1 is down-regulated and functions as a tumor-suppressive circRNA by inhibiting malignant proliferation. METTL3-mediated m6A modification stabilizes and upregulates circDLC1, which sponges miR-671-5p to increase CTNNBIP1 transcription (circDLC1/miR-671-5p/CTNNBIP1 axis)."	0.8562
35474604	Thoracic cancer	2022	Activation of circ_0072088/miR-1261/PIK3CA pathway accelerates lung adenocarcinoma progression.	hsa_circ_0072088	circ_0072088 / circ 0072088	hsa_circ_ZFR	ZFR	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; ISH	"circ_0072088 is up-regulated in LUAD tissues/cells and mainly localized in the cytoplasm. It promotes LUAD cell proliferation, migration and invasion by acting as a ceRNA sponge for miR-1261, thereby increasing PIK3CA expression (circ_0072088/miR-1261/PIK3CA axis)."	0.8267
35475447	Molecular medicine reports	2022	"Knockdown of circ_0067934 inhibits gastric cancer cell proliferation, migration and invasion via the miR_1301_3p/KIF23 axis."	hsa_circ_0067934	circ_0067934 / circ-0067934			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_0067934 is upregulated in gastric cancer cell lines and functions as a pro-tumor circRNA by promoting proliferation, migration and invasion. Mechanistically, it sponges miR-1301-3p to relieve repression of KIF23, forming a circ_0067934/miR-1301-3p/KIF23 axis."	0.5997
35475453	Bioengineered	2022	CircMCTP2 (has-circ-0000658) facilitates the proliferation and metastasis of bladder carcinoma through modulating the miR-498/murine double minute-2 axis.	hsa_circ_0000658	CircMCTP2	hsa_circ_MCTP2	MCTP2	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; RNA-seq	"CircMCTP2 is up-regulated in bladder carcinoma and promotes proliferation, migration/invasion, and tumor growth. Mechanistically, it functions as a ceRNA by sponging miR-498 to increase MDM2, and high circMCTP2 expression is associated with poor overall survival."	0.8568
35476874	Journal of clinical laboratory analysis	2022	Upregulation of hsa_circ_0000977 participates in esophageal squamous cancer progression by sponging miR-874-3p.	hsa_circ_0000977	hsa_circRNA_0000977 / circ_0977	hsa_circ_NOL10	NOL10	Esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"In ESCC, hsa_circ_0000977 is up-regulated in patient plasma and shows strong diagnostic performance by ROC analysis. Functionally, it promotes ESCC cell proliferation and migration and inhibits apoptosis, at least partly by acting as a miRNA sponge (binding miR-874-3p) and potentially affecting downstream targets such as TP53INP2 and KMT2D."	0.7369
35478417	Journal of clinical laboratory analysis	2022	"Circular RNA mitochondrial translation optimization 1 correlates with less lymph node metastasis, longer disease-free survival, and higher chemotherapy sensitivity in gastric cancer."		circ_MTO1	hsa_circ_MTO1	MTO1	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"circ-MTO1 is down-regulated in gastric cancer tumor tissue and higher tumor circ-MTO1 levels are associated with less lymph node metastasis and lower TNM stage. Clinically, high tumor circ-MTO1 predicts longer disease-free survival, and experimentally circ-MTO1 overexpression increases oxaliplatin sensitivity in gastric cancer cell lines."	0.6866
35479829	Journal of inflammation research	2022	Circular RNA Fbxl5 Regulates Cardiomyocyte Apoptosis During Ischemia Reperfusion Injury via Sponging microRNA-146a.	mmu_circ_0001346	circRNA Fbxl5	mmu_circ_Fbxl5	Fbxl5	ischemia reperfusion injury / IRI	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR	"In mouse myocardial ischemia-reperfusion injury and NMVM anoxia/reoxygenation, circRNA Fbxl5 is up-regulated and promotes cardiomyocyte apoptosis. It functions as a ceRNA by sponging miR-146a, thereby relieving miR-146a-mediated repression of MED1 and exacerbating cell death; circRNA Fbxl5 knockdown reduces apoptosis, infarct size, and improves cardiac function."	0.7756
35480175	RSC advances	2021	A PCR-free screen-printed magnetic electrode for the detection of circular RNA from hepatocellular cancer based on a back-splice junction.		circCDYL	hsa_circ_CDYL		hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	Microarray	"The study develops a PCR-free electrochemical biosensor to detect circCDYL via BSJ-targeting capture probes and methylene-blue DPV readout, and verifies performance in human serum. circCDYL is described as specifically up-regulated in HCC and an independent marker for early-stage HCC detection."	0.1768
35481460	Bioengineered	2022	Circular GOLPH3 RNA exerts oncogenic effects in vitro by regulating the miRNA-1299/LIF axis in oral squamous cell carcinoma.	hsa_circ_0001470	circGOLPH3 / circular GOLPH3 RNA (circGOLPH3)	hsa_circ_GOLPH3	GOLPH3	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circGOLPH3 is up-regulated in OSCC cell lines and mainly localized in the cytoplasm. It promotes OSCC cell proliferation, migration, invasion, and xenograft tumor growth by acting as a ceRNA that sponges miR-1299, thereby increasing LIF expression through the circGOLPH3/miR-1299/LIF axis."	0.7753
35482475	Journal of diabetes investigation	2022	"Circular ribonucleic acid nucleoporin_98 knockdown alleviates high glucose-induced proliferation, fibrosis, inflammation and oxidative stress in human glomerular mesangial cells by regulating the microribonucleic acid-151-3p-high mobility group AT-hook_2 axis."	hsa_circ_0000274	circNUP98	hsa_circ_NUP98	NUP98	diabetic nephropathy / DN	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"circNUP98 is up-regulated in DN patient serum and in high glucose-stimulated HMCs. It mainly localizes to the cytoplasm and promotes HG-induced mesangial cell dysfunction (proliferation, fibrosis/ECM markers, inflammation, oxidative stress) by sponging miR-151-3p to upregulate HMGA2; it is also present in serum exosomes and shows diagnostic potential for DN."	0.8455
35484118	Cell death & disease	2022	CircMAN1A2 is upregulated by Helicobacter pylori and promotes development of gastric cancer.		circMAN1A2	hsa_circ_MAN1A2	MAN1A2	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"circMAN1A2 is induced/upregulated by H. pylori in gastric cancer cells and tissues, promotes malignant phenotypes (proliferation, migration, invasion) and enhances xenograft growth. Mechanistically, it mainly localizes to the cytoplasm and acts as a ceRNA by sponging miR-1236-3p to increase MTA2 expression, and it may serve as a diagnostic biomarker due to elevated levels in patient plasma."	0.7519
35484574	European journal of medical research	2022	CircCRIM1 promotes nasopharyngeal carcinoma progression via the miR-34c-5p/FOSL1 axis.		circCRIM1	hsa_circ_CRIM1	CRIM1	nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"circCRIM1 is up-regulated in NPC cell lines and promotes malignant phenotypes (viability/proliferation, migration, invasion). Mechanistically, circCRIM1 binds miR-34c-5p and increases the downstream target FOSL1, forming a circCRIM1/miR-34c-5p/FOSL1 regulatory axis."	0.5223
35484994	Bioengineered	2022	Down-regulated HSA_circ_0003528 inhibits hepatocellular carcinoma aggressiveness via the miR-212-3p/XIAP axis.	hsa_circ_0003528	circ_0003528			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circ_0003528 is up-regulated in HCC tissues/cells and mainly localized in the cytoplasm. Its knockdown reduces HCC cell viability, increases apoptosis, and suppresses xenograft tumor growth, functioning through a ceRNA mechanism by sponging miR-212-3p to regulate XIAP."	0.7486
35491723	Technology in cancer research & treatment	2022	CircRNA PTPRM Promotes Non-Small Cell Lung Cancer Progression by Modulating the miR-139-5p/SETD5 Axis.	hsa_circ_0007144	circRNA PTPRM / circPTPRM	hsa_circ_PTPRM	PTPRM	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circPTPRM is up-regulated in NSCLC tissues and cell lines and promotes NSCLC proliferation, migration, invasion and tumor growth while suppressing apoptosis. Mechanistically, circPTPRM functions as a ceRNA by sponging miR-139-5p, thereby relieving repression of SETD5 (circPTPRM/miR-139-5p/SETD5 axis)."	0.7552
35493197	International journal of general medicine	2022	Evaluation of Diagnostic and Prognostic Value of hsa_circ_0084927 and Analysis of Associated ceRNA Network in Colorectal Cancer.	hsa_circ_0084927		hsa_circ_ESRP1	ESRP1	colon adenocarcinoma / COAD	MONDO:0002271	colon adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0084927 is up-regulated in COAD tissues, cell lines, and patient plasma and promotes COAD cell proliferation, migration, and invasion. It is proposed to act via a ceRNA axis involving hsa-miR-106b-5p and VEGFA, and higher expression is associated with poorer overall survival and diagnostic potential in plasma."	0.7173
35493320	Frontiers in molecular neuroscience	2022	Identification of Potential Key circRNAs in Aged Mice With Postoperative Delirium.		mmu_circRNA_32003	mmu_circ_Pias2	Pias2	postoperative delirium / POD	MONDO:0002602	central nervous system disorder	up-regulated	RT-qPCR; Microarray	"mmu_circRNA_32003 is up-regulated in the hippocampus of aged mice with POD after tibial fracture surgery. The study provides predicted miRNA response elements for this circRNA, but does not experimentally validate a specific downstream mechanism or function in POD."	0.4997
35493320	Frontiers in molecular neuroscience	2022	Identification of Potential Key circRNAs in Aged Mice With Postoperative Delirium.		mmu_circRNA_016934	mmu_circ_Gm22632	Gm22632	postoperative delirium / POD	MONDO:0002602	central nervous system disorder	up-regulated	RT-qPCR; Microarray	mmu_circRNA_016934 is up-regulated in the hippocampus of aged POD model mice. The study reports predicted miRNA binding partners but does not validate downstream targets or functional effects.	0.4997
35493320	Frontiers in molecular neuroscience	2022	Identification of Potential Key circRNAs in Aged Mice With Postoperative Delirium.		mmu_circRNA_32141	mmu_circ_Ppp6r3	Ppp6r3	postoperative delirium / POD	MONDO:0002602	central nervous system disorder	up-regulated	RT-qPCR; Microarray	mmu_circRNA_32141 is up-regulated in the hippocampus of the aged mouse POD model and has bioinformatically predicted miRNA response elements. No specific functional assays or downstream targets are validated for this circRNA.	0.4997
35493320	Frontiers in molecular neuroscience	2022	Identification of Potential Key circRNAs in Aged Mice With Postoperative Delirium.		mmu_circRNA_29678	mmu_circ_Stxbp5l	Stxbp5l	postoperative delirium / POD	MONDO:0002602	central nervous system disorder	up-regulated	RT-qPCR; Microarray	mmu_circRNA_29678 is up-regulated in the hippocampus of aged mice with POD. The paper provides predicted miRNA interactors but does not experimentally demonstrate a mechanistic or phenotypic role for this circRNA.	0.4997
35493320	Frontiers in molecular neuroscience	2022	Identification of Potential Key circRNAs in Aged Mice With Postoperative Delirium.		mmu_circRNA_22546	mmu_circ_Tmtc2	Tmtc2	postoperative delirium / POD	MONDO:0002602	central nervous system disorder	up-regulated	RT-qPCR; Microarray	"mmu_circRNA_22546 is up-regulated in the hippocampus of aged POD model mice. Predicted miRNA response elements are provided, but no specific biological function or validated regulatory axis is established."	0.4997
35493320	Frontiers in molecular neuroscience	2022	Identification of Potential Key circRNAs in Aged Mice With Postoperative Delirium.		mmu_circRNA_29619	mmu_circ_Adcy5	Adcy5	postoperative delirium / POD	MONDO:0002602	central nervous system disorder	down-regulated	RT-qPCR; Microarray	mmu_circRNA_29619 is down-regulated in the hippocampus of aged POD model mice and has predicted miRNA response elements. The study does not validate a direct functional role or downstream targets for this circRNA in POD.	0.4997
35493320	Frontiers in molecular neuroscience	2022	Identification of Potential Key circRNAs in Aged Mice With Postoperative Delirium.		mmu_circRNA_40568	mmu_circ_Prickle2	Prickle2	postoperative delirium / POD	MONDO:0002602	central nervous system disorder	down-regulated	RT-qPCR; Microarray	mmu_circRNA_40568 is down-regulated in the hippocampus of aged POD model mice and has predicted miRNA response elements. The study does not experimentally validate its biological function or downstream targets in POD.	0.4997
35493320	Frontiers in molecular neuroscience	2022	Identification of Potential Key circRNAs in Aged Mice With Postoperative Delirium.		mmu_circRNA_31992	mmu_circ_Zbtb7c	Zbtb7c	postoperative delirium / POD	MONDO:0002602	central nervous system disorder	down-regulated	RT-qPCR; Microarray	mmu_circRNA_31992 is down-regulated in the hippocampus of aged POD model mice and has predicted miRNA response elements. The study does not validate its functional consequences in POD.	0.4997
35493320	Frontiers in molecular neuroscience	2022	Identification of Potential Key circRNAs in Aged Mice With Postoperative Delirium.		mmu_circRNA_26701 / Circ_Homer1	mmu_circ_HOMER1	HOMER1 / Homer1	postoperative delirium / POD	MONDO:0002602	central nervous system disorder	up-regulated	RT-qPCR; Microarray	"Circ_Homer1 (mmu_circRNA_26701), derived from the Homer1/HOMER1 gene, is significantly up-regulated in the hippocampus of aged mice with POD after tibial fracture surgery. The authors highlight it as specifically altered in glutamate synapse-related signaling, but its causal molecular mechanism in POD remains to be experimentally confirmed."	0.4997
35493998	Frontiers in oncology	2022	Silencing circOMA1 Inhibits Osteosarcoma Progression by Sponging miR-1294 to Regulate c-Myc Expression.	hsa_circ_0002316	circOMA1	hsa_circ_OMA1	OMA1	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"circOMA1 (hsa_circ_0002316), derived from OMA1, is up-regulated in osteosarcoma tissues and cell lines and mainly localizes to the cytoplasm. It promotes osteosarcoma malignant phenotypes and tumor growth by sponging miR-1294, thereby increasing c-Myc expression (circOMA1/miR-1294/c-Myc axis)."	0.8635
35494315	Journal of inflammation research	2022	Identification of a circRNA/miRNA/mRNA ceRNA Network as a Cell Cycle-Related Regulator for Chronic Sinusitis with Nasal Polyps.	hsa_circ_0031594	Circ-EGLN3	hsa_circ_EGLN3	EGLN3	Chronic sinusitis with nasal polyps / CRSwNP	MONDO:0006031	chronic rhinosinusitis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0031594 is up-regulated in CRSwNP nasal polyp tissues and shows strong diagnostic discrimination. It localizes to the cytoplasm and may function as a ceRNA sponge for hsa-miR-1260b and hsa-miR-6507-5p, thereby positively regulating cell-cycle related targets such as NCAPG2 and PRC1; siRNA knockdown reverses these expression patterns in HNEpC cells."	0.6033
35496045	BioMed research international	2022	Mechanism of RNA circHIPK3 Involved in Resistance of Lung Cancer Cells to Gefitinib.		circHIPK3	hsa_circ_HIPK3	HIPK3	lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	"circHIPK3 is down-regulated in lung cancer tissues and is associated with more advanced tumor characteristics (larger tumor diameter, higher TNM stage, lymph node metastasis). Reduced circHIPK3 expression is linked to enhanced gefitinib resistance in lung adenocarcinoma cells, accompanied by decreased gefitinib-mediated apoptosis, and circHIPK3 shows diagnostic potential by ROC analysis."	0.7035
35500159	Journal of clinical laboratory analysis	2022	Circular RNA hsa_circ_0004396 acts as a sponge of miR-615-5p to promote non-small cell lung cancer progression and radioresistance through the upregulation of P21-Activated Kinase 1.	hsa_circ_0004396	circHUWE1	hsa_circ_HUWE1	HUWE1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0004396 (circHUWE1) is upregulated in NSCLC and promotes malignant phenotypes and radioresistance. Mechanistically, it sponges miR-615-5p to increase PAK1 expression, and its knockdown suppresses tumor growth in a nude-mouse xenograft model."	0.8426
35502885	Bioengineered	2022	"Circular RNA CircSHKBP1 accelerates the proliferation, invasion, angiogenesis, and stem cell-like properties via modulation of microR-766-5p/high mobility group AT-hook 2 axis in laryngeal squamous cell carcinoma."		circSHKBP1 / Circular SHKBP1 (circSHKBP)	hsa_circ_SHKBP1	SHKBP1	laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR	"circSHKBP1 is up-regulated in LSCC tissues and cell lines and is associated with poorer overall survival. Functionally, circSHKBP1 promotes LSCC proliferation, invasion, angiogenesis, stemness, and xenograft tumor growth by acting as a ceRNA that sponges miR-766-5p to derepress HMGA2."	0.8534
35504843	International wound journal	2022	Analysis of circRNA-mRNA expression profiles and functional enrichment in diabetes mellitus based on high throughput sequencing.		circRNA CNOT6	hsa_circ_CNOT6	CNOT6	Type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	dysregulated	RNA-seq	"Serum circRNA CNOT6 is identified as differentially expressed between DM/T2DM and NDM groups by RNA-seq and is reported to be associated with diabetes progression. Its downstream miRNA/mRNA interactions are predicted within a circRNA-miRNA-mRNA (ceRNA) network, but no circRNA-specific experimental validation is provided."	0.1768
35504843	International wound journal	2022	Analysis of circRNA-mRNA expression profiles and functional enrichment in diabetes mellitus based on high throughput sequencing.		circRNA AXIN1	hsa_circ_AXIN1	AXIN1	Type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	dysregulated	RNA-seq	"Serum circRNA AXIN1 is identified as differentially expressed between DM/T2DM and NDM groups by RNA-seq and is reported to be associated with diabetes progression. It is included in a predicted circRNA-miRNA-mRNA (ceRNA) network, but the paper provides no circRNA-specific experimental validation of mechanism."	0.1768
35504887	Cell death discovery	2022	circDHTKD1 promotes lymphatic metastasis of bladder cancer by upregulating CXCL5.	hsa_circ_0007813	circDHTKD1	hsa_circ_DHTKD1	DHTKD1	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; RNA-seq	"circDHTKD1 is up-regulated in bladder cancer and associated with lymph node metastasis. It promotes lymphangiogenesis and metastasis by sponging miR-149-5p to upregulate CXCL5, which recruits/activates neutrophils and increases VEGF-C to further enhance lymphangiogenesis."	0.8837
35505304	BMC gastroenterology	2022	CircRNA circ-ATAD1 suppresses miR-618 maturation to participate in colorectal cancer.		circ-ATAD1	hsa_circ_ATAD1	ATAD1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ-ATAD1 is up-regulated in colorectal cancer and promotes CRC cell proliferation. Mechanistically, it directly binds premature miR-618, suppressing miR-618 maturation (reduced mature miR-618), and high circ-ATAD1 expression is associated with worse overall survival."	0.7513
35508616	Cell death discovery	2022	Circ_0000811 acts as a miR-15b sponge and inhibits Prkar2a-mediated JAK2/STAT1 pathway to attenuate cerebral ischemic vertigo.	mmu_circ_0000811	circ_0000811	mmu_circ_Dlgap1	Dlgap1	cerebral ischemic vertigo / CI-induced vertigo	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR; RNA-seq	"In a mouse CI-induced vertigo model and OGD-treated HT22 neurons, circ_0000811 is down-regulated and functions as a ceRNA by sponging miR-15b. By relieving miR-15b-mediated suppression of Prkar2a, circ_0000811 inhibits JAK2/STAT1 signaling, reduces neuronal apoptosis, and alleviates vertigo phenotypes; it is proposed as a potential biomarker/therapeutic target."	0.8271
35509064	Journal of experimental & clinical cancer research : CR	2022	EIF4A3-induced circTOLLIP promotes the progression of hepatocellular carcinoma via the miR-516a-5p/PBX3/EMT pathway.	hsa_circ_0008301	circTOLLIP	hsa_circ_TOLLIP	TOLLIP	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circTOLLIP (hsa_circ_0008301), derived from TOLLIP, is up-regulated in hepatocellular carcinoma and associated with poor OS/DFS. It promotes HCC proliferation and metastasis by acting as a ceRNA that sponges miR-516a-5p to increase PBX3 and activate EMT, while its biogenesis is enhanced by the RBP EIF4A3."	0.8944
35509844	Journal of oncology	2022	circ-0007707/miR-429/PDGFD Pathway Regulates the Progression of Gastric Cancer by Modulating the Immune-Gene Signature.	hsa_circ_0007707	circ-0007707 / circ_0007707			gastric cancer / GC	MONDO:0001056	gastric cancer	dysregulated	RT-qPCR; Microarray	"circ-0007707 is implicated in gastric cancer as a ceRNA that sponges miR-429, thereby increasing PDGFD expression. This axis is proposed to influence gastric cancer progression by modulating the tumor immune microenvironment and an immune-gene signature."	0.3213
35510365	Bioengineered	2022	circSTRN3 aggravates sepsis-induced acute kidney injury by regulating miR-578/ toll like receptor 4 axis.		hsa_circ_010157 / circSTRN3	hsa_circ_STRN3	STRN3	sepsis-induced acute kidney injury	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR	"circSTRN3 is upregulated in sepsis-associated AKI (patient serum and LPS-treated HK2 cells) and aggravates kidney cell injury. It sponges/negatively regulates miR-578, leading to increased TLR4, thereby promoting inflammation, apoptosis and fibrosis and suppressing proliferation in LPS-induced AKI models."	0.7796
35510394	Bioengineered	2022	Circular RNA PUM1 performs as a competing endogenous RNA of microRNA-340-5p to mediate DEAD-box helicase 5 to mitigate cerebral ischemia-reperfusion injury.		circPUM1 / Circular RNA PUM1	hsa_circ_PUM1	PUM1	cerebral ischemia-reperfusion injury	MONDO:0005203	ischemia reperfusion injury	down-regulated	RT-qPCR	"circPUM1 is down-regulated in tMCAO mouse brain and OGD/R-treated SH-SY5Y cells. Functionally, circPUM1 overexpression alleviates neuronal injury (reduced apoptosis, inflammation, LDH release) by sponging miR-340-5p to increase DDX5 and suppress NF-kappaB pathway activation."	0.6279
35513835	Journal of experimental & clinical cancer research : CR	2022	EIF4A3-regulated circ_0087429 can reverse EMT and inhibit the progression of cervical cancer via miR-5003-3p-dependent upregulation of OGN expression.	hsa_circ_0087429	circ_0087429 / hsa_circRNA_104814	hsa_circ_SPIN1	SPIN1	cervical cancer / CC	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR; Microarray	"circ_0087429 is down-regulated in cervical cancer and functions as a tumour suppressor. It mainly localizes to the cytoplasm and sponges miR-5003-3p to upregulate OGN, thereby reversing EMT and inhibiting proliferation, migration/invasion, angiogenesis, and in vivo growth/metastasis. EIF4A3 binds the flanking regions and suppresses circ_0087429 biogenesis/expression."	0.8562
35515212	RSC advances	2019	Circular RNA SMARCA5 inhibits gastric cancer progression through targeting the miR-346/ FBXL2 axis.		Circular RNA (circRNA) SMARCA5 / circSMARCA5	hsa_circ_SMARCA5	SMARCA5	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"circSMARCA5 is down-regulated in gastric cancer tissues and cell lines. Its overexpression suppresses gastric cancer cell proliferation, migration, and invasion by sponging miR-346 and relieving miR-346-mediated repression of FBXL2 (miR-346/FBXL2 axis)."	0.6479
35520785	RSC advances	2019	Knockdown of circPVT1 inhibits progression of papillary thyroid carcinoma by sponging miR-126.		circPVT1 / circRNA plasmacytoma variant translocation gene 1 (circPVT1)	hsa_circ_PVT1	PVT1	papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circPVT1 is up-regulated in papillary thyroid carcinoma and its high expression correlates with worse overall survival. Functionally, circPVT1 promotes PTC cell viability, migration and invasion while inhibiting apoptosis, at least partly by sponging miR-126; circPVT1 knockdown suppresses xenograft tumor growth."	0.7548
35522944	Clinical and translational medicine	2022	CircRNA DDX21 acts as a prognostic factor and sponge of miR-1264/QKI axis to weaken the progression of triple-negative breast cancer.		circRNA DDX21	hsa_circ_DDX21	DDX21	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	down-regulated	RT-qPCR; Microarray	"circDDX21 is down-regulated in TNBC and suppresses malignant behaviors (proliferation, migration, invasion, EMT and metastasis). Mechanistically, it acts as a ceRNA that sponges miR-1264 to relieve repression of QKI, with downstream inhibition of p38 MAPK signaling."	0.8498
35523949	Laboratory investigation; a journal of technical methods and pathology	2022	CircRTN4 aggravates mesangial cell dysfunction by activating the miR-513a-5p/FN axis in lupus nephritis.	hsa_circ_0054595	circRTN4 / circRNA-0054595	hsa_circ_RTN4	RTN4	lupus nephritis / LN	MONDO:0005556	lupus nephritis	up-regulated	RT-qPCR; ISH; Microarray	"circRTN4 (hsa_circ_0054595) is up-regulated in lupus nephritis and mainly localizes to the cytoplasm. It promotes mesangial cell proliferation and extracellular matrix deposition by sponging miR-513a-5p to increase FN expression, and it can be transferred from monocytes to HRMCs via exosomes. Clinically, elevated circRTN4 in PBMCs and kidney tissues is proposed as a biomarker and therapeutic target for LN."	0.7534
35524161	Thoracic cancer	2022	Circ_0005231 promotes the progression of esophageal squamous cell carcinoma via sponging miR-383-5p and regulating KIAA0101.	hsa_circ_0005231	circ_0005231	hsa_circ_EIF3H	EIF3H	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0005231 is up-regulated in ESCC plasma, tumor tissues and ESCC cell lines and mainly localizes to the cytoplasm. It promotes ESCC proliferation, migration, invasion and EMT by sponging miR-383-5p and thereby increasing KIAA0101 expression; circ_0005231 knockdown suppresses xenograft tumor growth."	0.8399
35524319	Molecular cancer	2022	M6A-mediated upregulation of circMDK promotes tumorigenesis and acts as a nanotherapeutic target in hepatocellular carcinoma.	hsa_circ_0095868	circMDK	hsa_circ_MDK	MDK	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circMDK (hsa_circ_0095868), derived from MDK exon 5, is up-regulated in hepatocellular carcinoma and promotes proliferation, migration and invasion while inhibiting apoptosis. It acts as a ceRNA by sponging miR-346 and miR-874-3p to upregulate ATG16L1 and activate PI3K/AKT/mTOR signaling, and its increased level is linked to poor prognosis; m6A-related binding by IGF2BP1 enhances circMDK stability."	0.8854
35525866	Cell death & disease	2022	Circular RNA circVAMP3 promotes aerobic glycolysis and proliferation by regulating LDHA in renal cell carcinoma.	hsa_circ_0006354	circVAMP3	hsa_circ_VAMP3	VAMP3	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR; Microarray	"circVAMP3 is upregulated in RCC/ccRCC and correlates with advanced TNM stage. It promotes aerobic glycolysis and proliferation by directly binding LDHA and enhancing FGFR1-dependent LDHA Y10 phosphorylation, increasing LDHA activity and tumor growth in xenografts."	0.8794
35525959	Molecular cancer	2022	The circular RNA circHMGB2 drives immunosuppression and anti-PD-1 resistance in lung adenocarcinomas and squamous cell carcinomas via the miR-181a-5p/CARM1 axis.	hsa_circ_0071452	circHMGB2	hsa_circ_HMGB2	HMGB2	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circHMGB2 (hsa_circ_0071452), derived from HMGB2, is upregulated in NSCLC (including LUAD and LUSC) and predicts poor prognosis. It acts as a ceRNA to sponge miR-181a-5p, increasing CARM1 to suppress the type 1 IFN/JAK-STAT response and promote an immunosuppressive microenvironment, thereby reducing anti-PD-1 therapeutic efficacy."	0.8879
35527788	Oncology letters	2022	"hsa_circ_0000523/miR-let-7b/METTL3 axis regulates proliferation, apoptosis and metastasis in the HCT116 human colorectal cancer cell line."	hsa_circ_0000523	circ_0000523 / circ6229	hsa_circ_METTL3	METTL3	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	unknown	RT-qPCR	"In HCT116 colorectal cancer cells, hsa_circ_0000523 promotes proliferation and invasion and inhibits apoptosis. Mechanistically, it forms a hsa_circ_0000523/miR-let-7b/METTL3 regulatory axis in which circ_0000523 suppresses miR-let-7b and thereby increases METTL3 expression."	0.528
35529258	Computational and mathematical methods in medicine	2022	GEO Database Screening Combined with In Vitro Experiments to Study the Mechanism of hsa_circ_0003570 in Infantile Hemangiomas.	hsa_circ_0003570				infantile hemangioma / IH	MONDO:0002407	capillary hemangioma	up-regulated	RT-qPCR; Microarray	"In infantile hemangioma endothelial cells, hsa_circ_0003570 is upregulated and promotes malignant behaviors (proliferation/migration/invasion) while inhibiting apoptosis. Mechanistically, it functions as a ceRNA sponging hsa-miR-138-5p to increase RGS5 expression."	0.5979
35530358	Frontiers in oncology	2022	Circular RNA ERBIN Promotes Proliferation of Hepatocellular Carcinoma via the miR-1263/CDK6 Axis.	hsa_circ_0001492	circERBIN	hsa_circ_ERBIN	Erbin	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circERBIN is upregulated in HCC and mainly localized in the cytoplasm. It promotes HCC cell proliferation and tumor growth by sponging miR-1263 to increase CDK6 expression and accelerate G1/S transition, and high circERBIN is associated with poorer overall survival."	0.8309
35534866	Journal of experimental & clinical cancer research : CR	2022	FMRP ligand circZNF609 destabilizes RAC1 mRNA to reduce metastasis in acral melanoma and cutaneous melanoma.		circZNF609	hsa_circ_ZNF609	ZNF609	melanoma	MONDO:0005105	melanoma	down-regulated	RT-qPCR; Microarray	"circZNF609 is down-regulated in acral and cutaneous melanoma and functions as a metastasis suppressor. It localizes mainly in the cytoplasm and binds the RBP FMRP to enhance FMRP_RAC1 mRNA interaction, decreasing RAC1 mRNA stability and RAC1 expression, thereby inhibiting melanoma migration/invasion and in vivo metastasis; low circZNF609 is associated with worse patient survival."	0.8709
35535385	Journal of clinical laboratory analysis	2022	Hsa_circ_0000285 contributes to gastric cancer progression by upregulating FN1 through the inhibition of miR-1278.	hsa_circ_0000285	circ_0000285	hsa_circ_HIPK3	HIPK3	Gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"hsa_circ_0000285 is upregulated in gastric cancer and mainly localized in the cytoplasm. It promotes GC cell proliferation and invasion and inhibits apoptosis by sponging miR-1278, thereby increasing FN1 expression via the hsa_circ_0000285/miR-1278/FN1 ceRNA axis."	0.7631
35535387	Journal of clinical laboratory analysis	2022	Hsa_circ_0003748 promotes disease progression in rheumatic valvular heart disease by sponging miR-577.	hsa_circ_0003748		hsa_circ_IP6K2	IP6K2	rheumatic valvular heart disease / RVHD	MONDO:0006955	rheumatic heart disease	up-regulated	RT-qPCR; Microarray	"In RVHD-derived hVICs, hsa_circ_0003748 is upregulated and mainly localized in the cytoplasm. It promotes proliferation and migration, reduces apoptosis, and alters cell-cycle distribution (notably G2/M arrest upon overexpression) by acting as a sponge for miR-577, supported by luciferase and rescue experiments; pathway analyses implicate MAPK/Ras-related signaling."	0.6867
35538499	Journal of experimental & clinical cancer research : CR	2022	A novel protein encoded by ZCRB1-induced circHEATR5B suppresses aerobic glycolysis of GBM through phosphorylation of JMJD5.	hsa_circ_0054048	circHEATR5B / circ_0054048	hsa_circ_HEATR5B	HEATR5B	glioblastoma / GBM	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR; Microarray	"circHEATR5B is down-regulated in GBM and mainly localized in the cytoplasm. Its overexpression suppresses glycolysis (glucose consumption, lactate production, ECAR) and proliferation of GBM cells and inhibits xenograft growth. Mechanistically, ZCRB1 promotes Alu-dependent formation of circHEATR5B; circHEATR5B is translated into HEATR5B-881aa, which phosphorylates JMJD5 to reduce its stability, impacting PKM2 activity and glycolysis."	0.7851
35538537	Journal of translational medicine	2022	Hsa_circ_0000497 and hsa_circ_0000918 contributed to peritoneal metastasis of ovarian cancer via ascites.	hsa_circ_0000497	circ_0000497	hsa_circ_SLAIN1	SLAIN1	epithelial ovarian cancer / EOC	MONDO:0005140	ovarian carcinoma	unknown	RT-qPCR; RNA-seq	"In EOC ascitic metastasis, hsa_circ_0000497 promotes ovarian cancer cell migration and invasion in vitro, consistent with an EMT-promoting role. The study also constructed a predicted circRNA_miRNA_mRNA ceRNA network as a potential mechanism."	0.7046
35538537	Journal of translational medicine	2022	Hsa_circ_0000497 and hsa_circ_0000918 contributed to peritoneal metastasis of ovarian cancer via ascites.	hsa_circ_0000918		hsa_circ_GMIP	GMIP	epithelial ovarian cancer / EOC	MONDO:0005140	ovarian carcinoma	up-regulated	RT-qPCR; RNA-seq	"In EOC, hsa_circ_0000918 is up-regulated in ascites tumor cells versus primary and metastatic lesions, and it promotes migration/invasion (metastatic traits) by enhancing EMT in vitro. A predicted circRNA_miRNA_mRNA ceRNA network was built to suggest downstream regulatory targets."	0.7046
35543347	Bioengineered	2022	"Circular RNA circRNA-0039459 promotes the migration, invasion, and proliferation of liver cancer cells through the adsorption of miR-432."	hsa_circ_0039459	circRNA-0039459 / circ-0039459			liver cancer	MONDO:0002691	liver cancer	up-regulated	RT-qPCR	"circ-0039459 is up-regulated in liver cancer/HCC tissues and cell lines. It promotes proliferation, migration, invasion and EMT and suppresses apoptosis by sponging miR-432, thereby de-repressing SYVN1."	0.7936
35543376	Bioengineered	2022	Propofol modulates glycolysis reprogramming of ovarian tumor via restraining circular RNA-zinc finger RNA-binding protein/microRNA-212-5p/superoxide dismutase 2 axis.		circ-ZFR / circular RNA-zinc finger RNA-binding protein (ZFR)	hsa_circ_ZFR	ZFR	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"In A2780 ovarian cancer cells, circ-ZFR is increased and promotes malignant phenotypes and aerobic glycolysis. Propofol lowers circ-ZFR, relieving its sponge effect on miR-212-5p and thereby reducing SOD2, which restrains glycolysis and cell progression."	0.6253
35545766	The journal of physiological sciences : JPS	2022	"Hsa_circ_0000345 inhibits cell proliferation, migration and invasion of nasopharyngeal carcinoma cells via miR-513a-3p/PTEN axis."	hsa_circ_0000345				nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	down-regulated	RT-qPCR	"In NPC cell lines, hsa_circ_0000345 is down-regulated and suppresses proliferation, migration, and invasion. Mechanistically, it acts as a ceRNA that sponges miR-513a-3p to release PTEN, forming a miR-513a-3p/PTEN regulatory axis."	0.5554
35546161	Scientific reports	2022	High-throughput analysis of ANRIL circRNA isoforms in human pancreatic islets.		circANRIL / circular ANRIL	hsa_circ_CDKN2B-AS	CDKN2B-AS	Type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	unknown	RT-qPCR; RNA-seq	"This study profiles circANRIL isoforms in human pancreatic islets and validates predominant back-splice junctions. A higher circANRIL:linANRIL ratio is associated with reduced beta-cell proliferation and is increased in carriers of a T2D-risk SNP in ANRIL exon 2. circANRIL is predominantly cytoplasmic and shows enriched predicted miRNA target sites, suggesting potential post-transcriptional regulatory roles."	0.7785
35546161	Scientific reports	2022	High-throughput analysis of ANRIL circRNA isoforms in human pancreatic islets.		circANRIL 7_5	hsa_circ_CDKN2B-AS	CDKN2B-AS	Type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	unknown	RT-qPCR; RNA-seq	The circANRIL back-splice junction isoform 7_5 is among the most abundant circANRIL isoforms in human pancreatic islets and was quantified/validated by qRT-PCR in islets and endoC-betaH1 cells.	0.4773
35546161	Scientific reports	2022	High-throughput analysis of ANRIL circRNA isoforms in human pancreatic islets.		circANRIL 10_5	hsa_circ_CDKN2B-AS	CDKN2B-AS	Type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	unknown	RT-qPCR; RNA-seq	The circANRIL back-splice junction isoform 10_5 is one of the most abundant circANRIL isoforms in human pancreatic islets and was quantified by qRT-PCR in islets and endoC-betaH1 cells.	0.4773
35546161	Scientific reports	2022	High-throughput analysis of ANRIL circRNA isoforms in human pancreatic islets.		circANRIL 16_5	hsa_circ_CDKN2B-AS	CDKN2B-AS	Type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	unknown	RT-qPCR; RNA-seq	The circANRIL back-splice junction isoform 16_5 is one of the most abundant circANRIL isoforms in human pancreatic islets and was quantified by qRT-PCR in islets and endoC-betaH1 cells.	0.4773
35546161	Scientific reports	2022	High-throughput analysis of ANRIL circRNA isoforms in human pancreatic islets.		circANRIL 16_4	hsa_circ_CDKN2B-AS	CDKN2B-AS	Type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	unknown	RT-qPCR; RNA-seq	The circANRIL back-splice junction 16_4 was selected as a predominant isoform for RT-qPCR validation (with RNase R enrichment) in endoC-betaH1 cells and quantified in human islet samples.	0.4773
35546509	Bioengineered	2022	Circ 003390/Eukaryotic translation initiation factor 4A3 promoted cell migration and proliferation in endometrial cancer via vascular endothelial growth factor signaling by miR-195-5p.		circ 003390 / circWEE1	hsa_circ_WEE1	WEE1	Endometrial cancer / EC	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR	"circWEE1 is up-regulated in endometrial cancer and promotes proliferation, migration/invasion while inhibiting apoptosis. Mechanistically, circWEE1 acts as a ceRNA sponging miR-195-5p to increase VEGFA and activate downstream VEGF/PI3K/AKT signaling; eIF4A3 binds the circWEE1 transcript and facilitates its cyclization/biogenesis."	0.728
35547007	Frontiers in endocrinology	2022	Exosomal RNA Expression Profiles and Their Prediction Performance in Patients With Gestational Diabetes Mellitus and Macrosomia.	hsa_circ_0014635	circ_0014635			gestational diabetes mellitus / GDM	MONDO:0005406	gestational diabetes	up-regulated	RT-qPCR; Microarray	"Exosomal circ_0014635 is up-regulated in cord blood exosomes from GDM-related macrosomia (GDM-M) cases versus controls and was validated by qPCR. The study did not experimentally define a specific downstream target/axis for circ_0014635, and its predictive performance in peripheral blood exosomes was not highlighted as effective."	0.4032
35549631	Bioengineered	2022	Circular RNA_0120376 regulates microRNA-148b-3 and centrosomal protein 55 to promote non-small cell lung cancer development.	hsa_circ_0120376	circ_0120376 / circ-Rtn4	hsa_circ_Rtn4	Rtn4	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0120376 is up-regulated in NSCLC tissues and cell lines and is associated with advanced T stage and lymph node metastasis. It promotes NSCLC cell proliferation, migration and invasion while inhibiting apoptosis by acting as a ceRNA that sponges miR-148b-3p and thereby increases CEP55 expression."	0.7045
35549806	Bioengineered	2022	"Circular_0086414 induces SPARC like 1 (SPARCL1) production to inhibit esophageal cancer cell proliferation, invasion and glycolysis and induce cell apoptosis by sponging miR-1290."	hsa_circ_0086414	circ_0086414 / Circular_0086414	hsa_circ_BNC2	BNC2	esophageal cancer / EC	MONDO:0007576	esophageal cancer	down-regulated	RT-qPCR	"circ_0086414 is down-regulated in esophageal cancer and acts as a tumor suppressor. It mainly localizes in the cytoplasm and functions as a ceRNA by sponging miR-1290, thereby increasing SPARCL1 expression to inhibit proliferation, invasion and glycolysis while promoting apoptosis, and it suppresses xenograft tumor growth."	0.7761
35549985	Bioengineered	2022	CircRNA protein tyrosine phosphatase receptor type a suppresses proliferation and induces apoptosis of lung adenocarcinoma cells via regulation of microRNA-582-3p.		circRNA_PTPRA	hsa_circ_PTPRA	PTPRA	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR	"circRNA_PTPRA is down-regulated in lung adenocarcinoma tissues/cells and functions as a tumor suppressor by inhibiting proliferation and promoting apoptosis. Mechanistically, it sponges miR-582-3p and negatively regulates its expression, and miR-582-3p overexpression reverses circRNA_PTPRA¡¯s effects."	0.6996
35550610	Journal of ovarian research	2022	Plasma circRNA microarray profiling identifies novel circRNA biomarkers for the diagnosis of ovarian cancer.	hsa_circ_0003972	circ-0003972 / circ_0003972			ovarian cancer / OC	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0003972 is down-regulated in ovarian cancer plasma, tissues, and cell lines and shows diagnostic value (AUC 0.724). It is included in the circCOMBO diagnostic model and is predicted to act via a ceRNA (miRNA sponging) network affecting hub genes."	0.6556
35550610	Journal of ovarian research	2022	Plasma circRNA microarray profiling identifies novel circRNA biomarkers for the diagnosis of ovarian cancer.	hsa_circ_0007288	circ-0007288			ovarian cancer / OC	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0007288 is down-regulated in ovarian cancer plasma, tissues, and cell lines and has diagnostic value (AUC 0.790). Higher expression is associated with lower lymph node metastasis potential, and bioinformatics suggests a ceRNA network involving multiple oncogenic miRNAs and hub genes."	0.6556
35559038	Frontiers in genetics	2022	The Regulatory Network and Role of the circRNA-miRNA-mRNA ceRNA Network in the Progression and the Immune Response of Wilms Tumor Based on RNA-Seq.		circEYA1	hsa_circ_EYA1	EYA1	Wilms tumor / WT	MONDO:0006058	Wilms tumor	up-regulated	RT-qPCR; RNA-seq	"circEYA1 is up-regulated in Wilms tumor tissues and promotes malignant phenotypes in WT-CLS1 cells. Knockdown of circEYA1 suppresses proliferation, migration, and invasion and alters cell-cycle distribution, potentially via a circEYA1/miR-619-5p/TP53 ceRNA axis."	0.7032
35559038	Frontiers in genetics	2022	The Regulatory Network and Role of the circRNA-miRNA-mRNA ceRNA Network in the Progression and the Immune Response of Wilms Tumor Based on RNA-Seq.		circZNF208	hsa_circ_ZNF208		Wilms tumor / WT	MONDO:0006058	Wilms tumor	unknown	RT-qPCR	"circZNF208 was selected as one of the top differentially expressed circRNAs from the ceRNA subnetwork and its expression was validated by RT-qPCR in clinical samples, consistent with sequencing results."	0.2995
35559038	Frontiers in genetics	2022	The Regulatory Network and Role of the circRNA-miRNA-mRNA ceRNA Network in the Progression and the Immune Response of Wilms Tumor Based on RNA-Seq.		circPKHD1	hsa_circ_PKHD1		Wilms tumor / WT	MONDO:0006058	Wilms tumor	unknown	RT-qPCR	"circPKHD1 was selected as one of the top differentially expressed circRNAs from the ceRNA subnetwork and its expression was validated by RT-qPCR in clinical samples, consistent with sequencing results."	0.2995
35559038	Frontiers in genetics	2022	The Regulatory Network and Role of the circRNA-miRNA-mRNA ceRNA Network in the Progression and the Immune Response of Wilms Tumor Based on RNA-Seq.	hsa_circ_0001900				Wilms tumor / WT	MONDO:0006058	Wilms tumor	dysregulated	RT-qPCR	"hsa_circ_0001900 was among four differentially expressed circRNAs selected to validate the circRNA-seq results by RT-qPCR, with consistent expression trends; its back-splice junction was also among the two circRNAs verified by Sanger sequencing."	0.385
35559038	Frontiers in genetics	2022	The Regulatory Network and Role of the circRNA-miRNA-mRNA ceRNA Network in the Progression and the Immune Response of Wilms Tumor Based on RNA-Seq.	hsa_circ_0009035				Wilms tumor / WT	MONDO:0006058	Wilms tumor	dysregulated	RT-qPCR	"hsa_circ_0009035 was among four differentially expressed circRNAs selected to validate the circRNA-seq results by RT-qPCR, and its back-splice junction was confirmed by Sanger sequencing."	0.385
35559038	Frontiers in genetics	2022	The Regulatory Network and Role of the circRNA-miRNA-mRNA ceRNA Network in the Progression and the Immune Response of Wilms Tumor Based on RNA-Seq.		circNPNT	hsa_circ_NPNT		Wilms tumor / WT	MONDO:0006058	Wilms tumor	dysregulated	RT-qPCR	"circNPNT was among four differentially expressed circRNAs selected to validate the circRNA-seq results by RT-qPCR, with results consistent with sequencing trends."	0.279
35559038	Frontiers in genetics	2022	The Regulatory Network and Role of the circRNA-miRNA-mRNA ceRNA Network in the Progression and the Immune Response of Wilms Tumor Based on RNA-Seq.	hsa_circ_0072391				Wilms tumor / WT	MONDO:0006058	Wilms tumor	dysregulated	RT-qPCR	"hsa_circ_0072391 was among four differentially expressed circRNAs selected to validate the circRNA-seq results by RT-qPCR, with results consistent with sequencing trends."	0.279
35563023	International journal of molecular sciences	2022	Bioinformatics and Screening of a Circular RNA-microRNA-mRNA Regulatory Network Induced by Coxsackievirus Group B5 in Human Rhabdomyosarcoma Cells.		novel_circ_0002006 / circRNA0002006			Coxsackievirus Group B5 infection	MONDO:0005721	coxsackievirus infectious disease	down-regulated	RT-qPCR; RNA-seq	"In CVB5-infected RD cells, novel_circ_0002006 is down-regulated but shows antiviral activity when overexpressed, suppressing CVB5 replication and VP1. It is linked to IFN-I/IFN signaling and is predicted to function as a miRNA sponge (notably for miR-152-3p) within a circRNA_miRNA_mRNA network."	0.4474
35563023	International journal of molecular sciences	2022	Bioinformatics and Screening of a Circular RNA-microRNA-mRNA Regulatory Network Induced by Coxsackievirus Group B5 in Human Rhabdomyosarcoma Cells.		novel_circ_0001066 / circRNA0001066			Coxsackievirus Group B5 infection	MONDO:0005721	coxsackievirus infectious disease	up-regulated	RT-qPCR; RNA-seq	"In CVB5-infected RD cells, novel_circ_0001066 is up-regulated and participates in an NF-kappaB signaling pathway-related circRNA_miRNA_mRNA network. It is predicted to sponge miR-29b-3p and, when overexpressed, modulates miRNAs (miR-29b-3p/miR-567/miR-15b-3p) and contributes to inhibition of CVB5 infection."	0.4474
35563023	International journal of molecular sciences	2022	Bioinformatics and Screening of a Circular RNA-microRNA-mRNA Regulatory Network Induced by Coxsackievirus Group B5 in Human Rhabdomyosarcoma Cells.	hsa_circ_0008378				Coxsackievirus Group B5 infection	MONDO:0005721	coxsackievirus infectious disease	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0008378 is down-regulated in CVB5-infected RD cells compared with mock-infected controls and was among the circRNAs validated by RT-qPCR.	0.1904
35563023	International journal of molecular sciences	2022	Bioinformatics and Screening of a Circular RNA-microRNA-mRNA Regulatory Network Induced by Coxsackievirus Group B5 in Human Rhabdomyosarcoma Cells.	hsa_circ_0004390				Coxsackievirus Group B5 infection	MONDO:0005721	coxsackievirus infectious disease	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0004390 is down-regulated in CVB5-infected RD cells compared with mock-infected controls and was among the circRNAs validated by RT-qPCR.	0.1904
35563023	International journal of molecular sciences	2022	Bioinformatics and Screening of a Circular RNA-microRNA-mRNA Regulatory Network Induced by Coxsackievirus Group B5 in Human Rhabdomyosarcoma Cells.	hsa_circ_0075346				Coxsackievirus Group B5 infection	MONDO:0005721	coxsackievirus infectious disease	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0075346 is up-regulated after CVB5 infection in RD cells, validated by RT-qPCR, and was included among circRNAs used to construct innate immune-related circRNA_miRNA_mRNA interaction networks."	0.2465
35563023	International journal of molecular sciences	2022	Bioinformatics and Screening of a Circular RNA-microRNA-mRNA Regulatory Network Induced by Coxsackievirus Group B5 in Human Rhabdomyosarcoma Cells.	hsa_circ_0031831				Coxsackievirus Group B5 infection	MONDO:0005721	coxsackievirus infectious disease	unknown	RNA-seq	"hsa_circ_0031831 was selected as an innate-immunity-enriched circRNA and included in the IFN signaling pathway-related circRNA_miRNA_mRNA interaction network during CVB5 infection, but its expression change direction and specific functional effects were not reported."	0.1768
35563023	International journal of molecular sciences	2022	Bioinformatics and Screening of a Circular RNA-microRNA-mRNA Regulatory Network Induced by Coxsackievirus Group B5 in Human Rhabdomyosarcoma Cells.		novel_circ_0010492			Coxsackievirus Group B5 infection	MONDO:0005721	coxsackievirus infectious disease	up-regulated	RT-qPCR; RNA-seq	novel_circ_0010492 is up-regulated after CVB5 infection in RD cells and its differential expression was validated by RT-qPCR; no further mechanism or functional characterization was provided.	0.1904
35565775	Nutrients	2022	Supplementation with Milk-Derived Extracellular Vesicles Shapes the Gut Microbiota and Regulates the Transcriptomic Landscape in Experimental Colitis.	mmu_circ_0001505	circRNA_0001505			colitis	MONDO:0005292	colitis	up-regulated	RNA-seq	mmu_circ_0001505 (also referred to as circRNA_0001505) was identified by colon-tissue RNA-seq as differentially expressed and up-regulated in the EV-treated (DSS+MID) group compared with DSS-induced colitis mice. Its functional role and downstream targets were not experimentally validated; only miRNA-binding predictions were performed at the network level.	0.31
35565775	Nutrients	2022	Supplementation with Milk-Derived Extracellular Vesicles Shapes the Gut Microbiota and Regulates the Transcriptomic Landscape in Experimental Colitis.		circRNA_0001652 / novel_circ_0001652			colitis	MONDO:0005292	colitis	up-regulated	RNA-seq	novel_circ_0001652 (also referred to as circRNA_0001652) was identified by colon-tissue RNA-seq as differentially expressed and up-regulated in the EV-treated (DSS+MID) group compared with DSS-induced colitis mice. Its functional role and downstream targets were not experimentally validated; only miRNA-binding predictions were performed at the network level.	0.31
35565775	Nutrients	2022	Supplementation with Milk-Derived Extracellular Vesicles Shapes the Gut Microbiota and Regulates the Transcriptomic Landscape in Experimental Colitis.	mmu_circ_0000898	circRNA_0000898			colitis	MONDO:0005292	colitis	down-regulated	RNA-seq	mmu_circ_0000898 (also referred to as circRNA_0000898) was identified by colon-tissue RNA-seq as differentially expressed and down-regulated in the EV-treated (DSS+MID) group compared with DSS-induced colitis mice. Its functional role and downstream targets were not experimentally validated; only miRNA-binding predictions were performed at the network level.	0.31
35565775	Nutrients	2022	Supplementation with Milk-Derived Extracellular Vesicles Shapes the Gut Microbiota and Regulates the Transcriptomic Landscape in Experimental Colitis.	mmu_circ_0001887	circRNA_0001887 / circ_0001887			colitis	MONDO:0005292	colitis	down-regulated	RNA-seq	"mmu_circ_0001887 (also referred to as circRNA_0001887 and circ_0001887) was identified by colon-tissue RNA-seq as differentially expressed and down-regulated in EV-treated (DSS+MID) colitis mice. The study further predicted that circ_0001887 could bind multiple miRNAs, but did not validate specific miRNAs or downstream effectors experimentally."	0.31
35565775	Nutrients	2022	Supplementation with Milk-Derived Extracellular Vesicles Shapes the Gut Microbiota and Regulates the Transcriptomic Landscape in Experimental Colitis.	mmu_circ_0000117	circRNA_0000117 / novel_circ_0000117			colitis	MONDO:0005292	colitis	down-regulated	RNA-seq	"novel_circ_0000117 (also referred to as circRNA_0000117 and circ_0000117) was identified by colon-tissue RNA-seq as differentially expressed and down-regulated in EV-treated (DSS+MID) colitis mice. The paper reports it contains an IRES element (IRES score 0.780) and performed miRNA-binding predictions, but did not validate translation or specific miRNA/target effects experimentally."	0.31
35565775	Nutrients	2022	Supplementation with Milk-Derived Extracellular Vesicles Shapes the Gut Microbiota and Regulates the Transcriptomic Landscape in Experimental Colitis.	mmu_circ_0000500	circRNA_0000500 / novel_circ_0000500			colitis	MONDO:0005292	colitis	down-regulated	RNA-seq	"novel_circ_0000500 (also referred to as circRNA_0000500 and circ_0000500) was identified by colon-tissue RNA-seq as differentially expressed and down-regulated in EV-treated (DSS+MID) colitis mice. The paper reports it contains an IRES element (IRES score 0.770) and performed miRNA-binding predictions, but did not validate translation or specific miRNA/target effects experimentally."	0.31
35567340	Thoracic cancer	2022	"Circ_0001273 downregulation inhibits the growth, migration and glutamine metabolism of esophageal cancer cells via targeting the miR-622/SLC1A5 signaling axis."	hsa_circ_0001273	circ_0001273 / hsa_circRNA_406237	hsa_circ_OXNAD1	OXNAD1	esophageal cancer / EC	MONDO:0007576	esophageal cancer	up-regulated	RT-qPCR; Microarray	"circ_0001273 is up-regulated in esophageal cancer and promotes malignant phenotypes (proliferation, migration, EMT, glutamine metabolism) while inhibiting apoptosis. It functions as a ceRNA by sponging miR-622 to increase SLC1A5 expression, thereby promoting tumor growth in a xenograft model and showing diagnostic value by ROC analysis."	0.786
35568705	Cell death discovery	2022	CircEIF3H-IGF2BP2-HuR scaffold complex promotes TNBC progression via stabilizing HSPD1/RBM8A/G3BP1 mRNA.	hsa_circ_0005231	circEIF3H	hsa_circ_EIF3H	EIF3H	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; RNA-seq	"circEIF3H (hsa_circ_0005231), derived from EIF3H, is up-regulated in breast cancer (especially TNBC) and high expression predicts poor overall survival. Functionally, it promotes TNBC proliferation and metastasis. Mechanistically, circEIF3H serves as a scaffold for IGF2BP2 and HuR, enhancing stability of HSPD1/RBM8A/G3BP1 mRNAs rather than acting as a miRNA sponge."	0.8933
35570745	Bioengineered	2022	Circular RNA (circ)_0129047 upregulates bone morphogenetic protein receptor type 2 expression to inhibit lung adenocarcinoma progression by sponging microRNA (miR)-1206.	hsa_circ_0129047	circ_0129047			lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; Microarray	"circ_0129047 is down-regulated in lung adenocarcinoma tissues/cell lines and functions as a tumor suppressor. It mainly localizes to the cytoplasm and inhibits malignant phenotypes by sponging miR-1206, thereby upregulating BMPR2."	0.8067
35571014	Frontiers in genetics	2022	A Circ-0007022/miR-338-3p/Neuropilin-1 Axis Reduces the Radiosensitivity of Esophageal Squamous Cell Carcinoma by Activating Epithelial-To-Mesenchymal Transition and PI3K/AKT Pathway.	hsa_circ_0007022	circRNA-0007022	hsa_circ_SAE1	SAE1	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ-0007022 is up-regulated in radioresistant ESCC cells and in tumors from radiotherapy-insensitive patients. It promotes post-irradiation proliferation/migration and reduces radiosensitivity by sponging miR-338-3p to upregulate NRP1, which activates EMT and PI3K/AKT signaling, thereby enhancing radioresistance."	0.8533
35571241	Oxidative medicine and cellular longevity	2022	circPTP4A2-miR-330-5p-PDK2 Signaling Facilitates In Vivo Survival of HuMSCs on SF-SIS Scaffolds and Improves the Repair of Damaged Endometrium.		circPTP4A2	hsa_circ_PTP4A2	PTP4A2	Intrauterine adhesion / IUA / Asherman's syndrome	MONDO:0015299	Asherman syndrome	up-regulated	RT-qPCR; RNA-seq	"circPTP4A2 is upregulated in HuMSCs cultured on SF-SIS scaffolds and in transplanted endometrial tissues in an IUA mouse model. It mainly localizes to the cytoplasm and promotes HuMSC mitochondrial metabolism under hypoxia by sponging miR-330-5p to regulate PDK2, thereby improving endometrial repair (more glands and less fibrosis)."	0.7385
35571247	Oxidative medicine and cellular longevity	2022	circHtra1/miR-3960/GRB10 Axis Promotes Neuronal Loss and Immune Deficiency in Traumatic Brain Injury.	hsa_circ_0020269	circHtra1 / circRNA_0020269	hsa_circ_HTRA1	Htra1	traumatic brain injury / TBI	MONDO:0858950	traumatic brain injury	up-regulated	RT-qPCR; Microarray	"circHtra1 (has_circ_0020269/circRNA_0020269) is upregulated in blood after TBI and increases with injury severity. It promotes neuronal death by sponging miR-3960 to derepress GRB10, enhancing apoptosis and impairing neuronal proliferation; its expression is modulated by IGF-1/ADAR1-related A-to-I editing and it is proposed as a TBI biomarker/therapeutic target."	0.7122
35572733	BioMed research international	2022	circZNF91 Promotes the Malignant Phenotype of Chronic Lymphocytic Leukemia Cells by Targeting the miR-1283/WEE1 Axis.		circZNF91	hsa_circ_ZNF91	ZNF91	chronic lymphocytic leukemia / CLL	MONDO:0003864	chronic lymphocytic leukemia/small lymphocytic lymphoma	up-regulated	RT-qPCR	"circZNF91 is up-regulated in CLL peripheral blood and CLL cell lines, where it supports proliferation and cell-cycle progression and suppresses apoptosis. Mechanistically, circZNF91 functions as a ceRNA that sponges miR-1283, thereby de-repressing WEE1 to promote malignant phenotypes. Clinically, higher circZNF91 correlates with diagnostic potential and poorer survival."	0.8347
35573701	Frontiers in cell and developmental biology	2022	Bioinformatics Study Revealed Significance of Exosome Transcriptome in Hepatocellular Carcinoma Diagnosis.	hsa_circ_0014088				Hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	dysregulated	Microarray	"This study identified has-circ-0014088 as a hub circRNA in an exosomal ceRNA network distinguishing HCC from normal samples, based on database-derived differential expression and predicted miRNA binding. No experimental validation or functional assays for this circRNA were reported."	0.1768
35573701	Frontiers in cell and developmental biology	2022	Bioinformatics Study Revealed Significance of Exosome Transcriptome in Hepatocellular Carcinoma Diagnosis.	hsa_circ_0001380				Hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	dysregulated	Microarray	This study reported hsa circ 0001380/has-circ-0001380 as the most significant differentially expressed exosomal circRNA between normal and HCC samples in exoRBase-derived data. The work did not provide circRNA-specific mechanistic experiments or clinical validation for this circRNA.	0.1155
35575762	Aging	2022	CircRNA has_circ_0069313 induced OSCC immunity escape by miR-325-3p-Foxp3 axes in both OSCC cells and Treg cells.	hsa_circ_0069313				oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"has_circ_0069313 is up-regulated in OSCC tissues and cell lines and is associated with worse overall survival. Mechanistically, it sponges miR-325-3p to prevent miR-325-3p-mediated Foxp3 degradation, thereby maintaining Foxp3 and enhancing immune-escape related phenotypes (including increased PDL1), and it can be transferred via OSCC-derived exosomes to Treg cells to promote Treg function."	0.8413
35576496	Journal of clinical laboratory analysis	2022	"Hsa_circ_0001982 promotes the proliferation, invasion, and multidrug resistance of osteosarcoma cells."	hsa_circ_0001982	circRNA RNF111 / circ_0001982	hsa_circ_RNF111	RNF111	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"hsa_circ_0001982 is up-regulated in osteosarcoma tissues/cells and further increased in chemoresistant samples. Functionally, it promotes proliferation, colony formation, migration/invasion and multidrug resistance in OS cells, and it can directly bind miR-143 and negatively regulate miR-143 expression, supporting a circRNA/miRNA regulatory mechanism."	0.6479
35576499	Journal of clinical laboratory analysis	2022	"circ_0004872 inhibits proliferation, invasion, and glycolysis of oral squamous cell carcinoma by sponged miR-424-5p."	hsa_circ_0004872	circ_0004872 / circ0004872			oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR	"circ_0004872 is down-regulated in OSCC tissues and cell lines. Its overexpression suppresses OSCC cell proliferation, invasion, and glycolysis and increases apoptosis by sponging miR-424-5p, and it is proposed as a potential diagnostic/therapeutic target."	0.6825
35579082	Cancer science	2022	CircPCBP2 promotes the stemness and chemoresistance of DLBCL via targeting miR-33a/b to disinhibit PD-L1.	hsa_circ_0026652	circPCBP2 / circ_PCBP2	hsa_circ_PCBP2	PCBP2	Diffuse large B-cell lymphoma / DLBCL	MONDO:0018905	diffuse large B-cell lymphoma	up-regulated	RT-qPCR	"circPCBP2 is up-regulated in DLBCL tissues and cell lines and mainly localizes to the cytoplasm. It promotes DLBCL stemness and CHOP chemoresistance by sponging miR-33a/b, thereby relieving repression of PD-L1 and activating downstream ERK/AKT and JAK2/STAT3 signaling; high circPCBP2 correlates with poorer overall survival."	0.8814
35579354	mBio	2022	Assessment of the Abundance and Potential Function of Human Papillomavirus Type 16 Circular E7 RNA.		HPV16 circE7 / circE7		HPV16 E7	cervical cancer / head and neck squamous cell carcinoma (HNSCC) / anal squamous cell cancer / vulvar squamous cell cancer	MONDO:0024609	vulvar squamous cell carcinoma	unknown	RT-qPCR; Northern Blot; RNA-seq	"This letter argues that HPV16 circE7 is reliably detectable and more abundant than previously estimated when assessed by orthogonal methods (qRT-PCR, Northern blot, and RNA-seq). Functional evidence from inducible shRNA knockdown/rescue and expression constructs indicates circE7 can be translated to produce E7 oncoprotein and support cell proliferation."	0.6435
35579738	Molecular biology reports	2022	CircKIF4A enhances osteosarcoma proliferation and metastasis by sponging MiR-515-5p and upregulating SLC7A11.	hsa_circ_0007255	circKIF4A / hsa_circRNA_0007255	hsa_circ_KIF4A	KIF4A	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circKIF4A is up-regulated in osteosarcoma tissues and cell lines and promotes OS proliferation, invasion, and lung metastasis. Mechanistically, it functions as a ceRNA that sponges miR-515-5p, relieving repression of SLC7A11 (AGO2/RISC-associated), with effects linked to ferroptosis-related redox status (GSH/GSSG)."	0.8278
35581180	Cell death & disease	2022	CircLIFR suppresses hepatocellular carcinoma progression by sponging miR-624-5p and inactivating the GSK-3beta/beta-catenin signaling pathway.	hsa_circ_0072309	circLIFR	hsa_circ_LIFR	LIFR	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"circLIFR (hsa_circ_0072309), derived from LIFR, is down-regulated in HCC tissues and functions as a tumor suppressor. It sponges miR-624-5p to increase GSK-3beta, promoting beta-catenin degradation and inhibiting Wnt/beta-catenin signaling, thereby reducing HCC cell proliferation and invasion and suppressing tumor growth in xenograft models. Higher circLIFR levels are associated with better OS and RFS in the patient cohort."	0.896
35582416	International journal of medical sciences	2022	Hsa_circRNA_0040462: a sensor of cells' response to CAP treatment with double-edged roles on breast cancer malignancy.	hsa_circ_0040462		hsa_circ_GLG1	GLG1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circRNA_0040462 is induced by CAP treatment in breast cancer cells and serves as a sensitive marker of CAP response. Functionally, it shows double-edged effects in TNBC cells: it restrains proliferation but enhances migratory ability, potentially through a circRNA_miRNA_mRNA network (hub hsa-miRNA-1-3p) and modulation of PI3K/AKT and MAPK signaling and p65 phosphorylation."	0.5008
35587154	Bioengineered	2022	Circular RNA circPFKP suppresses the proliferation and metastasis of gastric cancer cell via sponging miR-644 and regulating ADAMTSL5 expression.	hsa_circ_0006608	"circPFKP / circular phosphofructokinase, platelet"	hsa_circ_PFKP	PFKP	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"circPFKP is down-regulated in gastric cancer and functions as a tumor suppressor by inhibiting proliferation, migration/invasion and xenograft growth. Mechanistically, it acts as a ceRNA sponge for miR-644, thereby increasing ADAMTSL5 expression (circPFKP/miR-644/ADAMTSL5 axis)."	0.8508
35589691	Cell death & disease	2022	circ-Pank1 promotes dopaminergic neuron neurodegeneration through modulating miR-7a-5p/alpha-syn pathway in Parkinson's disease.		circ-Pank1 / mmu_circ_32463	mmu_circ_Pank1	Pank1	Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	up-regulated	RT-qPCR	"circ-Pank1 is up-regulated in rotenone-induced Parkinson¡¯s disease models and promotes dopaminergic neuron injury and locomotor dysfunction. Mechanistically, it acts as a cytoplasmic ceRNA that sponges miR-7a-5p, thereby increasing alpha-synuclein (SNCA/alpha-syn) expression; circ-Pank1 knockdown is protective in vitro and in vivo."	0.6777
35591844	Archives of medical science : AMS	2022	Circ-RHOJ.1 regulated myocardial cell proliferation and apoptosis via targeting the miR-124-3p/NRG-1 axis in myocardial ischemia/reperfusion injury.		circ-RHOJ.1	rno_circ_RHOJ	RHOJ	myocardial ischemia/reperfusion injury	MONDO:0005203	ischemia reperfusion injury	down-regulated	RT-qPCR	"In a rat myocardial cell I/R model, circ-RHOJ.1 is down-regulated and functions as a ceRNA that sponges miR-124-3p to increase NRG1 expression. Overexpression of circ-RHOJ.1 promotes myocardial cell proliferation and suppresses apoptosis and inflammatory cytokine responses after I/R injury."	0.5416
35592246	Frontiers in cell and developmental biology	2022	"CircFGGY Inhibits Cell Growth, Invasion and Epithelial-Mesenchymal Transition of Hepatocellular Carcinoma via Regulating the miR-545-3p/Smad7 Axis."	hsa_circ_0006633	circFGGY	hsa_circ_FGGY	FGGY	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"circFGGY (hsa_circ_0006633), derived from FGGY, is down-regulated in HCC and mainly localizes to the cytoplasm. It suppresses HCC proliferation, migration/invasion and EMT and inhibits xenograft tumor growth by sponging miR-545-3p to increase Smad7, thereby restraining TGF-beta/SMAD-driven EMT. Low circFGGY expression is associated with poor overall survival after hepatectomy, suggesting prognostic value."	0.8637
35592503	Molecular therapy. Nucleic acids	2022	CircERBB2IP promotes post-infarction revascularization via the miR-145a-5p/Smad5 axis.	hsa_circ_0001492	circERBB2IP	hsa_circ_ERBB2IP	ERBB2IP	myocardial infarction / MI	MONDO:0005068	myocardial infarction	unknown	RT-qPCR; RNA-seq	"In mouse myocardial infarction models and cardiac microvascular endothelial cells, circERBB2IP promotes post-infarction revascularization and endothelial proliferation/migration/tube formation. It is induced by GATA4 and acts as a ceRNA by sponging miR-145a-5p to increase Smad5, thereby enhancing angiogenesis and improving cardiac repair."	0.7769
35592503	Molecular therapy. Nucleic acids	2022	CircERBB2IP promotes post-infarction revascularization via the miR-145a-5p/Smad5 axis.	mmu_circ_0000495	circERBB2IP	mmu_circ_ERBB2IP	ERBB2IP	myocardial infarction / MI	MONDO:0005068	myocardial infarction	unknown	RT-qPCR; RNA-seq	"In mouse myocardial infarction models and cardiac microvascular endothelial cells, circERBB2IP promotes post-infarction revascularization and endothelial proliferation/migration/tube formation. It is induced by GATA4 and acts as a ceRNA by sponging miR-145a-5p to increase Smad5, thereby enhancing angiogenesis and improving cardiac repair."	0.7769
35593591	The Kaohsiung journal of medical sciences	2022	M2 macrophage facilitated angiogenesis in cutaneous squamous cell carcinoma via circ_TNFRSF21/miR-3619-5p/ROCK axis.	hsa_circ_0001610	circ_TNFRSF21 / circTNFRSF21	hsa_circ_TNFRSF21	TNFRSF21	cutaneous squamous cell carcinoma / cSCC	MONDO:0002529	skin squamous cell carcinoma	up-regulated	RT-qPCR	"circ_TNFRSF21 is up-regulated in cSCC tissues and elevated in M2 macrophages/TAMs. It promotes M2 macrophage-induced angiogenesis (endothelial migration, invasion, and tube formation) by sponging miR-3619-5p, thereby releasing ROCK2/ROCK signaling activity."	0.7537
35595754	Cell death & disease	2022	Oncogenic circTICRR suppresses autophagy via binding to HuR protein and stabilizing GLUD1 mRNA in cervical cancer.	hsa_circ_0036730	circTICRR	hsa_circ_TICRR	TICRR	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Northern Blot; RNA-seq	"circTICRR (hsa_circ_0036730) is up-regulated in cervical cancer and acts oncogenically by promoting proliferation and inhibiting apoptosis through suppression of autophagy. Mechanistically, circTICRR binds the RBP HuR (F287/F289 in HuR RRM3), enhances HuR recruitment to GLUD1 mRNA, stabilizes GLUD1 mRNA, and elevates GLUD1 protein to inhibit autophagic flux. circTICRR knockdown or a peptide blocking circTICRR-HuR interaction suppresses cell line-derived xenograft growth."	0.8456
35600155	Central-European journal of immunology	2022	Oxidized low-density lipoprotein contributes to injury of endothelial cells via the circ_0090231/miR-9-5p/TXNIP axis.	hsa_circ_0090231	circ_0090231	hsa_circ_USP9X	USP9X	atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"In an ox-LDL-induced HUVEC atherosclerosis-like injury model, circ_0090231 is up-regulated and promotes endothelial injury. Mechanistically, circ_0090231 sponges miR-9-5p to increase TXNIP, thereby enhancing apoptosis, oxidative stress and inflammatory cytokine production while impairing angiogenesis."	0.7406
35600372	Frontiers in oncology	2022	"The Expression Profile, Clinical Application and Potential Tumor Suppressing Mechanism of hsa_circ_0001675 in Head and Neck Carcinoma."	hsa_circ_0001675				head and neck cancer / HNC	MONDO:0005627	head and neck cancer	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001675 is significantly downregulated in head and neck cancer tissues and its low expression is associated with more advanced disease and worse patient survival. The study proposes that hsa_circ_0001675 may function as a tumor suppressor via a predicted ceRNA network, with a likely downstream hsa_circ_0001675/miR-577/TESC axis, supported indirectly by reduced TESC protein staining in tumors."	0.5734
35600959	Evidence-based complementary and alternative medicine : eCAM	2022	"Circ_0001998 Regulates the Proliferation, Invasion, and Apoptosis of Lung Adenocarcinoma via Sponging miR-145."	hsa_circ_0001998	Circ_0001998	hsa_circ_FUT8	FUT8	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circ_0001998 is upregulated in LUAD cell lines and promotes malignant phenotypes. Knockdown of circ_0001998 inhibits viability/proliferation/invasion and increases apoptosis, at least partly by sponging miR-145 (validated by luciferase and rescue with miR-145 inhibitor)."	0.6004
35602296	Journal of oncology	2022	hsa_circ_0001955 Promotes Colorectal Cancer Progression by Regulating miR-583/FGF21 Axis.	hsa_circ_0001955	circ_0001955 / circCAMSAP1	hsa_circ_CAMSAP1	CAMSAP1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"hsa_circ_0001955 is up-regulated in colorectal cancer tissues/cells and promotes malignant phenotypes (proliferation, migration, invasion) while inhibiting apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-583 to relieve repression of FGF21, thereby promoting CRC progression in vitro and in a HCT116 xenograft model."	0.8512
35603423	Bioengineered	2022	CircNMD3 relieves endothelial cell injury induced by oxidatively modified low-density lipoprotein through regulating miR-498/ BMP and activin membrane-bound inhibitor (BAMBI) axis.	hsa_circ_0004264	circNMD3	hsa_circ_NMD3	NMD3	atherosclerosis / AS	MONDO:0005311	atherosclerosis	down-regulated	RT-qPCR	"circNMD3 is down-regulated in AS patient serum and in ox-LDL-treated HUVECs. circNMD3 overexpression alleviates ox-LDL-induced endothelial injury by sponging miR-498 and restoring BAMBI expression, thereby reducing apoptosis, inflammatory cytokines and oxidative stress while improving proliferation."	0.7431
35609310	Bioengineered	2022	Oxymatrine induces anti-tumor response in cervical cancer by modulating circ_0008460/miR-197-3p/ribonucleotide reductase subunit M2 (RRM2).	hsa_circ_0008460	circ_0008460	hsa_circ_WHSC1	WHSC1	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ_0008460 is upregulated in cervical cancer tissues/cells and functions pro-tumor by promoting proliferation, migration and invasion and suppressing apoptosis. Mechanistically, it sponges miR-197-3p to increase RRM2 expression; oxymatrine inhibits CC partly by downregulating circ_0008460 and thereby activating the miR-197-3p/RRM2 axis."	0.7858
35609334	Bioengineered	2022	Circular RNA_0001187 participates in the regulation of ulcerative colitis development via upregulating myeloid differentiation factor 88.	hsa_circ_0001187	Circular RNA_0001187 / circRNA_103124			ulcerative colitis / UC	MONDO:0005101	ulcerative colitis	up-regulated	RT-qPCR	"circ_0001187 is up-regulated in UC colonic mucosa and in UC patient serum exosomes, and promotes TNF-alpha-induced intestinal epithelial cell injury. Mechanistically, it functions as a ceRNA by sponging miR-1236-3p to de-repress MYD88, thereby enhancing apoptosis/inflammation/oxidative stress and suppressing proliferation in the TNF-alpha cell model; it is suggested as a diagnostic biomarker and therapeutic target for UC."	0.7412
35611168	PeerJ	2022	Potential and functional prediction of six circular RNAs as diagnostic markers for colorectal cancer.		hsa_circRNA_100833	hsa_circ_FADS2	FADS2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_100833 (host gene FADS2) is up-regulated in CRC tumor tissues versus adjacent normal tissues and shows diagnostic value by ROC analysis. The study predicts it may act in a circRNA_miRNA_mRNA ceRNA network, with a proposed core axis hsa_circRNA_100833_hsa-miR-124-5p_APLN, but the mechanism is not experimentally validated."	0.5963
35611168	PeerJ	2022	Potential and functional prediction of six circular RNAs as diagnostic markers for colorectal cancer.		hsa_circRNA_103828	hsa_circ_HMGCS1	HMGCS1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_103828 (host gene HMGCS1) is up-regulated in CRC tissues and has diagnostic value (AUC 0.8127). It is included in a predicted circRNA_miRNA_mRNA ceRNA network, but no circRNA-specific mechanism is experimentally validated in this paper."	0.5963
35611168	PeerJ	2022	Potential and functional prediction of six circular RNAs as diagnostic markers for colorectal cancer.		hsa_circRNA_103831	hsa_circ_HMGCS1	HMGCS1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_103831 (host gene HMGCS1) is up-regulated in CRC tissues and has diagnostic value (AUC 0.7502). A predicted ceRNA axis hsa_circRNA_103831_hsa-let-7c-5p_TP53 is proposed based on bioinformatics and TCGA-based hub gene screening, without direct mechanistic validation."	0.5963
35611168	PeerJ	2022	Potential and functional prediction of six circular RNAs as diagnostic markers for colorectal cancer.		hsa_circRNA_103752	hsa_circ_LRBA	LRBA	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_103752 (host gene LRBA) is significantly down-regulated in CRC tissues and shows very high diagnostic performance (AUC 0.9945). It is incorporated into a predicted circRNA_miRNA_mRNA ceRNA network, but its specific mechanistic axis is not experimentally validated in this study."	0.5963
35611168	PeerJ	2022	Potential and functional prediction of six circular RNAs as diagnostic markers for colorectal cancer.		hsa_circRNA_071106	hsa_circ_ARHGAP10	ARHGAP10	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_071106 (host gene ARHGAP10) is significantly down-regulated in CRC tissues and shows high diagnostic value (AUC 0.9642). The paper proposes a predicted ceRNA axis hsa_circRNA_071106_hsa-miR-6830-3p_UNKL based on bioinformatics/TCGA hub gene screening, without direct mechanistic validation."	0.5963
35611168	PeerJ	2022	Potential and functional prediction of six circular RNAs as diagnostic markers for colorectal cancer.		hsa_circRNA_102293	hsa_circ_MTCL1	MTCL1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_102293 (host gene MTCL1) is significantly down-regulated in CRC tissues and has diagnostic value (AUC 0.9486). The study predicts it may sponge miR-30 family members (miR-30b-5p and miR-30e_5p) within a circRNA_miRNA_mRNA ceRNA network, but does not experimentally validate this mechanism."	0.5963
35611198	World journal of clinical cases	2022	Identification of circ_0000375 and circ_0011536 as novel diagnostic biomarkers of colorectal cancer.	hsa_circ_0000375	circ_0000375	hsa_circ_IFFO1	IFFO1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0000375 (circ_0000375) is down-regulated in colorectal cancer tissues, serum, and CRC cell lines and shows strong diagnostic performance. Functionally, its overexpression suppresses CRC cell proliferation, migration, and invasion, and it acts as a miRNA sponge for miR-1182 as supported by luciferase assays."	0.814
35611198	World journal of clinical cases	2022	Identification of circ_0000375 and circ_0011536 as novel diagnostic biomarkers of colorectal cancer.	hsa_circ_0011536	circ_0011536	hsa_circ_ZMYM4	ZMYM4	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0011536 (circ_0011536) is down-regulated in colorectal cancer tissues, serum, and CRC cell lines and has strong diagnostic performance. Its overexpression suppresses CRC cell proliferation, migration, and invasion, and it functions as a miRNA sponge for miR-1246 as validated by luciferase assays."	0.814
35611368	OncoTargets and therapy	2022	"Circular RNA circLRCH3 Inhibits Proliferation, Migration, and Invasion of Colorectal Cancer Cells Through miRNA-223/LPP Axis."	hsa_circ_0008106	circLRCH3	hsa_circ_LRCH3	LRCH3	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	"In colorectal cancer, circLRCH3 is down-regulated and functions as a tumor suppressor. It sponges miR-223 to relieve repression of LPP, thereby inhibiting proliferation/migration/invasion and promoting apoptosis, and suppressing xenograft tumor growth."	0.7566
35611768	Bioengineered	2022	Knockout of circRNA single stranded interacting protein 1 (circRBMS1) played a protective role in myocardial ischemia-reperfusion injury though inhibition of miR-2355-3p/Mammalian Sterile20-like kinase 1 (MST1) axis.		circRBMS1 / circ-RBMS1	hsa_circ_RBMS1	RBMS1	myocardial ischemia/reperfusion injury	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR	"circRBMS1 is up-regulated in H/R-induced human cardiac myocytes and in the mouse myocardial I/R model. Silencing/knockout of circRBMS1 protects against I/R injury phenotypes by sponging miR-2355-3p and modulating the miR-2355-3p/MST1 axis, reducing apoptosis, oxidative stress, and inflammatory responses."	0.6278
35611880	Bioengineered	2022	Circ_0058792 regulates osteogenic differentiation through miR-181a-5p/Smad7 axis in steroid-induced osteonecrosis of the femoral head.	hsa_circ_0058792	circ_0058792 / Circ-0058792	hsa_circ_AGAP1	AGAP1	steroid-induced osteonecrosis of the femoral head / SONFH	MONDO:0012126	familial avascular necrosis of femoral head	up-regulated	RT-qPCR	"circ_0058792 is up-regulated in steroid-induced ONFH and functions as a ceRNA that sponges miR-181a-5p, thereby relieving repression of Smad7 and modulating TGF-beta/SMAD signaling (Smad2/3 phosphorylation). Functionally, circ_0058792 inhibits osteogenic differentiation in MC3T3-E1 cells, while its silencing enhances ALP activity and mineralization."	0.5554
35615399	Disease markers	2022	circ_000166/miR-296 Aggravates the Process of Diabetic Renal Fibrosis by Regulating the SGLT2 Signaling Pathway in Renal Tubular Epithelial Cells.		circRNA_000166			diabetic nephropathy / DN	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"In STZ-induced diabetic renal fibrosis (DN) models and HK-2 cells, circ_000166 is up-regulated and promotes renal fibrosis-related molecular changes and apoptosis. Mechanistically, circ_000166 functions as a ceRNA that sponges miR-296, thereby relieving repression of SGLT2 and aggravating diabetic renal fibrosis; silencing circ_000166 or restoring miR-296/knocking down SGLT2 mitigates these effects."	0.6479
35615580	Oxidative medicine and cellular longevity	2022	Extracellular Vesicle-Derived circITGB1 Regulates Dendritic Cell Maturation and Cardiac Inflammation via miR-342-3p/NFAM1.	hsa_circ_0018146	circITGB1 / hsa_circRNA_0018146	hsa_circ_ITGB1	ITGB1	acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR; Microarray	"In AMI patient plasma, circITGB1 is enriched in extracellular vesicles and is up-regulated. It sponges miR-342-3p to increase NFAM1, thereby modulating dendritic cell maturation and promoting cardiac inflammation/injury in an AMI mouse model."	0.7183
35619132	Molecular cancer	2022	PIK3CA mutations-mediated downregulation of circLHFPL2 inhibits colorectal cancer progression via upregulating PTEN.		circLHFPL2 / circLFHPL2	hsa_circ_LHFPL2	LHFPL2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"circLHFPL2 is downregulated in PIK3CA-mutant colorectal cancer and mainly localizes to the cytoplasm. It suppresses tumor progression by sponging miR-556-5p/miR-1322 to increase PTEN, thereby inhibiting PI3K/AKT signaling, and it can reverse PIK3CA-mediated MEK inhibitor resistance (via reducing P-gp/BCRP)."	0.8931
35620639	Regenerative therapy	2022	Circ_ROBO2/miR-186-5p/TRIM14 axis regulates oxidized low-density lipoprotein-induced cardiac microvascular endothelial cell injury.	hsa_circ_0124644	circ_ROBO2 / circ_0124644	hsa_circ_ROBO2	ROBO2	Coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR	"circ_ROBO2 is up-regulated in CAD patient serum and in ox-LDL-treated human CMECs. It mainly localizes to the cytoplasm and promotes ox-LDL-induced endothelial injury by sponging miR-186-5p to increase TRIM14, thereby reducing proliferation/angiogenesis and increasing apoptosis."	0.8119
35622733	Veterinary sciences	2022	CircRNA Expression Profiles in Canine Mammary Tumours.			cfa_circ_PDE3A	PDE3A	canine mammary tumours	MONDO:0700160	canine mammary adenoma	up-regulated	RT-qPCR; RNA-seq	"This up-regulated circRNA (from host gene PDE3A) was identified in canine mammary tumours vs adjacent normal tissues and is implicated by pathway analysis in the cAMP pathway, potentially affecting cell-cycle-related regulation."	0.429
35622733	Veterinary sciences	2022	CircRNA Expression Profiles in Canine Mammary Tumours.			cfa_circ_ATP2A2	ATP2A2	canine mammary tumours	MONDO:0700160	canine mammary adenoma	up-regulated	RT-qPCR; RNA-seq	This circRNA (host gene ATP2A2) is up-regulated in canine mammary tumours versus adjacent normal tissues and was highlighted among circRNAs associated with genes closely related to canine mammary tumours.	0.429
35622733	Veterinary sciences	2022	CircRNA Expression Profiles in Canine Mammary Tumours.			cfa_circ_HERC2	HERC2	canine mammary tumours	MONDO:0700160	canine mammary adenoma	up-regulated	RT-qPCR; RNA-seq	This circRNA (host gene HERC2) is up-regulated in canine mammary tumours compared with adjacent normal tissues and was among the 11 differentially expressed circRNAs validated by qRT-PCR.	0.429
35622733	Veterinary sciences	2022	CircRNA Expression Profiles in Canine Mammary Tumours.			cfa_circ_KCNQ1	KCNQ1	canine mammary tumours	MONDO:0700160	canine mammary adenoma	up-regulated	RT-qPCR; RNA-seq	This circRNA (host gene KCNQ1) is up-regulated in canine mammary tumours versus adjacent normal tissues and was among the 11 differentially expressed circRNAs validated by qRT-PCR.	0.429
35622733	Veterinary sciences	2022	CircRNA Expression Profiles in Canine Mammary Tumours.			cfa_circ_CREB3L2	CREB3L2	canine mammary tumours	MONDO:0700160	canine mammary adenoma	up-regulated	RT-qPCR; RNA-seq	This circRNA (host gene CREB3L2) is up-regulated in canine mammary tumours versus adjacent normal tissues and was among the 11 differentially expressed circRNAs validated by qRT-qPCR.	0.429
35622733	Veterinary sciences	2022	CircRNA Expression Profiles in Canine Mammary Tumours.			cfa_circ_ROCK2	ROCK2	canine mammary tumours	MONDO:0700160	canine mammary adenoma	down-regulated	RT-qPCR; RNA-seq	"This down-regulated circRNA (host gene ROCK2) was identified in canine mammary tumours vs adjacent normal tissues and is linked by pathway analysis to the cAMP pathway, potentially affecting cell-cycle-related regulation."	0.429
35622733	Veterinary sciences	2022	CircRNA Expression Profiles in Canine Mammary Tumours.			cfa_circ_GUCY1A2	GUCY1A2	canine mammary tumours	MONDO:0700160	canine mammary adenoma	down-regulated	RT-qPCR; RNA-seq	This circRNA (host gene GUCY1A2) is down-regulated in canine mammary tumours versus adjacent normal tissues and was among the 11 differentially expressed circRNAs validated by qRT-PCR.	0.429
35622733	Veterinary sciences	2022	CircRNA Expression Profiles in Canine Mammary Tumours.			cfa_circ_ULK2	ULK2	canine mammary tumours	MONDO:0700160	canine mammary adenoma	up-regulated	RT-qPCR; RNA-seq	"This circRNA (host gene ULK2) is up-regulated in canine mammary tumours vs adjacent normal tissues. The study suggests (by assumption/network analysis) it may act as an miRNA sponge, but specific miRNAs for this circRNA were not provided in the text."	0.4685
35622733	Veterinary sciences	2022	CircRNA Expression Profiles in Canine Mammary Tumours.			cfa_circ_TRIP12	TRIP12	canine mammary tumours	MONDO:0700160	canine mammary adenoma	up-regulated	RT-qPCR; RNA-seq	"This circRNA (host gene TRIP12) is up-regulated in canine mammary tumours versus adjacent normal tissues. The study reports predicted interaction with miR-7 and miR-34a, suggesting a miRNA-sponge/ceRNA-type regulatory role."	0.4685
35622733	Veterinary sciences	2022	CircRNA Expression Profiles in Canine Mammary Tumours.			cfa_circ_MFSD14A	MFSD14A	canine mammary tumours	MONDO:0700160	canine mammary adenoma	down-regulated	RT-qPCR; RNA-seq	"This circRNA (host gene MFSD14A) is down-regulated in canine mammary tumours vs adjacent normal tissues. The study suggests (by assumption/network analysis) it may act as an miRNA sponge, but specific miRNAs for this circRNA were not provided in the text."	0.4685
35622733	Veterinary sciences	2022	CircRNA Expression Profiles in Canine Mammary Tumours.			cfa_circ_MTHFD2L	MTHFD2L	canine mammary tumours	MONDO:0700160	canine mammary adenoma	down-regulated	RT-qPCR; RNA-seq	This circRNA (host gene MTHFD2L) is down-regulated in canine mammary tumours versus adjacent normal tissues and was among the 11 differentially expressed circRNAs validated by qRT-PCR.	0.429
35624451	Molecular cancer	2022	"The circSPON2/miR-331-3p axis regulates PRMT5, an epigenetic regulator of CAMK2N1 transcription and prostate cancer progression."	hsa_circ_0068835	circSPON2	hsa_circ_SPON2	SPON2	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; RNA-seq	"circSPON2 is upregulated in prostate cancer tissues/cell lines and is mainly cytoplasmic. It promotes proliferation, migration/invasion and metastasis by sponging miR-331-3p, thereby relieving miR-331-3p-mediated repression of PRMT5 and contributing to PRMT5-driven epigenetic suppression of CAMK2N1. High circSPON2 correlates with advanced clinicopathologic features and worse progression-free survival."	0.8815
35627232	Genes	2022	Hsa_circ_0006692 Promotes Lung Cancer Progression via miR-205-5p/CDK19 Axis.	hsa_circ_0006692				non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0006692 is up-regulated in NSCLC and functions as an oncogenic circRNA that promotes proliferation, migration/invasion and in vivo metastasis-like spread. Mechanistically, it sponges hsa-miR-205-5p to de-repress CDK19 and modulates EMT marker expression."	0.8279
35627270	Genes	2022	Identification of the circRNA-miRNA-mRNA Prognostic Regulatory Network in Lung Adenocarcinoma.	hsa_circ_0008234	hsa_circRNA_103415	hsa_circ_FOXP1	FOXP1	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	Microarray	"This study computationally identified hsa_circ_0008234 as up-regulated in LUAD microarray datasets and incorporated it into a predicted ceRNA network. The proposed axis is hsa_circ_0008234_hsa-miR-490-3p_SYT1, potentially related to LUAD pathogenesis and prognosis."	0.1768
35627270	Genes	2022	Identification of the circRNA-miRNA-mRNA Prognostic Regulatory Network in Lung Adenocarcinoma.	hsa_circ_0002360	hsa_circRNA_103123	hsa_circ_RUNX1	RUNX1	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	Microarray	"This study computationally identified hsa_circ_0002360 as down-regulated in LUAD microarray datasets and incorporated it into a predicted ceRNA network. The proposed axis is hsa_circ_0002360_hsa-miR-1293_(ADCY9, NMUR1), potentially related to LUAD pathogenesis and prognosis."	0.1768
35635053	Bioengineered	2022	Circ_0008068 facilitates the oral squamous cell carcinoma development by microRNA-153-3p/acylgycerol kinase (AGK) axis.	hsa_circ_0008068	circ_0008068	hsa_circ_KATNAL1	KATNAL1	Oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circ_0008068 is up-regulated in OSCC tissues and cell lines and mainly localizes to the cytoplasm. It promotes OSCC malignant phenotypes and glycolysis and inhibits apoptosis by sponging miR-153-3p to increase AGK expression, and its knockdown suppresses xenograft tumor growth."	0.8354
35635088	Bioengineered	2022	Circular RNA testis-expressed 14 overexpression induces apoptosis and suppresses migration of ox-LDL-stimulated vascular smooth muscle cells via regulating the microRNA 6509-3p/thanatos-associated domain-containing apoptosis-associated protein 1 axis.	hsa_circ_0107197	CircTEX14 / circRNA TEX14	hsa_circ_TEX14	TEX14	atherosclerosis / AS	MONDO:0005311	atherosclerosis	down-regulated	RT-qPCR	"In atherosclerosis, circTEX14 (hsa_circ_0107197) is down-regulated in patient serum and in ox-LDL-stimulated HA-VSMCs. circTEX14 overexpression suppresses VSMC proliferation and migration and promotes apoptosis by sponging miR-6509-3p and relieving its repression of THAP1."	0.7799
35635221	Innate immunity	2022	Circ_0066881 targets miR-144-5p/RORA axis to alleviate LPS-induced apoptotic and inflammatory damages in human periodontal ligament cells.	hsa_circ_0066881	circ_0066881	hsa_circ_CD80	CD80	periodontitis	MONDO:0005076	periodontitis	down-regulated	RT-qPCR	"circ_0066881 is down-regulated in periodontitis tissues and in LPS-treated human PDLCs. Functionally, circ_0066881 overexpression alleviates LPS-induced apoptosis and inflammatory cytokine release. Mechanistically, it acts as a miR-144-5p sponge to increase RORA expression, forming a circ_0066881/miR-144-5p/RORA ceRNA axis."	0.8111
35643814	Cell death & disease	2022	Exosomal circRNA BTG2 derived from RBP-J overexpressed-macrophages inhibits glioma progression via miR-25-3p/PTEN.		circBTG2 / circRNA BTG2	hsa_circ_BTG2	BTG2	glioma	MONDO:0021042	glioma	down-regulated	RT-qPCR; Microarray	"This study identifies exosomal circBTG2 (derived from BTG2) as a suppressor of glioma progression. circBTG2 inhibits glioma cell proliferation and invasion and suppresses xenograft growth by sponging miR-25-3p to increase PTEN expression, suggesting potential diagnostic/therapeutic value."	0.7795
35645729	Frontiers in neuroscience	2022	The Potential Circular RNAs Biomarker Panel and Regulatory Networks of Parkinson's Disease.	hsa_circ_0030428	hsa_circRNA_101275 / hsa_circ_101275			Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_101275 is up-regulated in peripheral blood of Parkinson¡¯s disease patients and is part of a 4-circRNA diagnostic panel with good discriminatory power. Bioinformatics suggests it may act via circRNA_miRNA_mRNA (ceRNA) networks and may be regulated by TH-related transcription factors (e.g., GATA2/GATA3), with enrichment in PI3K_Akt and MAPK pathways."	0.5963
35645729	Frontiers in neuroscience	2022	The Potential Circular RNAs Biomarker Panel and Regulatory Networks of Parkinson's Disease.	hsa_circ_0005654	hsa_circRNA_103730 / hsa_circ_103730			Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_103730 is up-regulated in peripheral blood of Parkinson¡¯s disease patients and contributes to a 4-circRNA diagnostic panel. Network analyses predict it may function through a circRNA_miRNA_mRNA (ceRNA) regulatory network and may be transcriptionally regulated by TH-related factors (e.g., GATA2/GATA3), with enrichment signals in PI3K_Akt and MAPK pathways."	0.5963
35645729	Frontiers in neuroscience	2022	The Potential Circular RNAs Biomarker Panel and Regulatory Networks of Parkinson's Disease.	hsa_circ_0038416	hsa_circRNA_038416 / hsa_circ_038416			Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_038416 is up-regulated in peripheral blood of Parkinson¡¯s disease patients and is included in a 4-circRNA diagnostic panel. The study provides expression/diagnostic evidence, while mechanistic links for this specific circRNA are not detailed beyond general pathway enrichment results for candidate circRNAs."	0.5662
35645729	Frontiers in neuroscience	2022	The Potential Circular RNAs Biomarker Panel and Regulatory Networks of Parkinson's Disease.	hsa_circ_0001081	hsa_circRNA_102850			Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_102850 is down-regulated in peripheral blood of Parkinson¡¯s disease patients and was selected (AUC > 0.70) for circRNA_miRNA_mRNA network prediction. It contributes to a multi-circRNA diagnostic panel with high AUC, and is predicted to function via ceRNA regulation with pathway enrichment signals in PI3K_Akt and MAPK."	0.5963
35646112	Journal of oncology	2022	circRNA TCFL5 Promote Esophageal Cancer Progression by Modulating M2 Macrophage Polarization via the miR-543-FMNL2 Axis.	hsa_circ_0061129	circRNA TCFL5	hsa_circ_TCFL5	TCFL5	Esophageal cancer / EC	MONDO:0007576	esophageal cancer	up-regulated	RT-qPCR; RNA-seq	"circRNA TCFL5 is up-regulated in esophageal cancer and promotes tumor cell proliferation, migration, and invasion as well as xenograft tumor growth. Mechanistically, it functions as a ceRNA by sponging miR-543 to increase FMNL2 expression, and it enhances M2 macrophage polarization through the same miR-543/FMNL2 axis."	0.7662
35646117	Journal of oncology	2022	CircNRIP1 Exerts Oncogenic Functions in Papillary Thyroid Carcinoma by Sponging miR-653-5p and Regulating PBX3 Expression.	hsa_circ_0004771	circ_0004771 / circNRIP1	hsa_circ_NRIP1	NRIP1	papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circNRIP1 (hsa_circ_0004771) is up-regulated in papillary thyroid carcinoma and promotes malignant phenotypes (proliferation, migration/invasion, tumor growth) while inhibiting apoptosis. Mechanistically, it functions as a ceRNA by sponging miR-653-5p to de-repress PBX3, and high circNRIP1 expression correlates with advanced TNM stage and poorer overall survival."	0.7944
35646637	Frontiers in oncology	2022	Exosomal Circsafb2 Reshaping Tumor Environment to Promote Renal Cell Carcinoma Progression by Mediating M2 Macrophage Polarization.		circSAFB2	hsa_circ_SAFB2	SAFB2	Renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR; Microarray	"circSAFB2 is up-regulated in RCC tissues and RCC-derived (including blood) exosomes, and can be transferred to macrophages. It promotes immune escape and RCC metastasis by sponging miR-620 and activating the JAK1/STAT3 pathway to drive M2 macrophage polarization."	0.786
35647294	Open life sciences	2022	Silencing circular RNA-friend leukemia virus integration 1 restrained malignancy of CC cells and oxaliplatin resistance by disturbing dyskeratosis congenita 1.	hsa_circ_0000370	circ-FLI1	hsa_circ_FLI1	FLI1	colon carcinoma	MONDO:0002032	colon carcinoma	up-regulated	RT-qPCR	"circ-FLI1 (hsa_circ_0000370), derived from FLI1, is up-regulated in colon carcinoma tissues and cell lines and is mainly localized in the cytoplasm. It promotes malignant phenotypes and oxaliplatin resistance by acting as a ceRNA that sponges miR-197-3p, thereby relieving repression of DKC1. High circ-FLI1 is associated with unfavorable overall survival and more advanced clinicopathological features."	0.8175
35650603	Molecular cancer	2022	CircSTX6 promotes pancreatic ductal adenocarcinoma progression by sponging miR-449b-5p and interacting with CUL2.	hsa_circ_0007905	circSTX6	hsa_circ_STX6	STX6	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circSTX6 (hsa_circ_0007905), derived from STX6, is up-regulated in PDAC and mainly localized in the cytoplasm. It promotes PDAC proliferation and metastasis by sponging miR-449b-5p to increase MYH9 and by binding CUL2 to inhibit HIF1A ubiquitination, enhancing HIF1A-driven MYH9 transcription; high circSTX6 is associated with worse overall survival."	0.8896
35650605	Journal of experimental & clinical cancer research : CR	2022	circPDE5A regulates prostate cancer metastasis via controlling WTAP-dependent N6-methyladenisine methylation of EIF3C mRNA.	hsa_circ_0002474	circPDE5A	hsa_circ_PDE5A	PDE5A	prostate cancer / PCa	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; Microarray	"circPDE5A is down-regulated in prostate cancer and functions as a metastasis suppressor. It binds WTAP and inhibits WTAP-dependent m6A methylation on EIF3C mRNA, reducing YTHDF1-associated translational output of EIF3C and thereby inactivating MAPK signaling to restrain migration/invasion and metastasis."	0.8304
35650643	Journal of ovarian research	2022	The molecular mechanism of circRHOBTB3 inhibits the proliferation and invasion of epithelial ovarian cancer by serving as the ceRNA of miR-23a-3p.	hsa_circ_0007444	circRHOBTB3	hsa_circ_RHOBTB3	RHOBTB3	epithelial ovarian cancer / EOC	MONDO:0005140	ovarian carcinoma	down-regulated	RT-qPCR	"circRHOBTB3 (hsa_circ_0007444), derived from RHOBTB3, is down-regulated in epithelial ovarian cancer and acts as a tumor suppressor. It sponges miR-23a-3p to restore PTEN expression and inhibit AKT activation, thereby suppressing proliferation, G1/S transition and invasion while promoting apoptosis, and it also reduces tumor growth in xenograft models."	0.8174
35652072	Frontiers in medicine	2022	Differentially Expressed Circular RNAs and Their Therapeutic Mechanism in Non-segmental Vitiligo Patients Treated With Methylprednisolone.		hsa_circRNA_100842 / circSLC3A2	hsa_circ_SLC3A2	SLC3A2	vitiligo	MONDO:0008661	vitiligo	down-regulated	Microarray	circSLC3A2 (hsa_circRNA_100842) was identified by circRNA microarray as a DEcircRNA that is down-regulated in peripheral blood after methylprednisolone treatment in non-segmental vitiligo patients. Bioinformatic prediction (TargetScan/miRanda) suggested binding with hsa-miR-23b-5p and hsa-miR-429 and linked this circRNA to the ferroptosis-related gene set.	0.329
35652072	Frontiers in medicine	2022	Differentially Expressed Circular RNAs and Their Therapeutic Mechanism in Non-segmental Vitiligo Patients Treated With Methylprednisolone.		hsa_circRNA_100283 / circGCLM	hsa_circ_GCLM	GCLM	vitiligo	MONDO:0008661	vitiligo	down-regulated	Microarray	"circGCLM (hsa_circRNA_100283) was identified as a ferroptosis-associated DEcircRNA that is down-regulated in peripheral blood after methylprednisolone treatment in vitiligo patients. Predicted miRNA binding partners include hsa-miR-576-5p and hsa-miR-383-5p, based on TargetScan/miRanda annotation."	0.329
35652072	Frontiers in medicine	2022	Differentially Expressed Circular RNAs and Their Therapeutic Mechanism in Non-segmental Vitiligo Patients Treated With Methylprednisolone.		hsa_circRNA_101076 / mmu_hsa_circRNA_101076 / circPCBP2	hsa_circ_PCBP2	PCBP2	vitiligo	MONDO:0008661	vitiligo	down-regulated	Microarray	circPCBP2 (hsa_circRNA_101076) was reported as down-regulated after methylprednisolone treatment in vitiligo patients and annotated as ferroptosis-related by enrichment analysis. Predicted interacting miRNAs include hsa-miR-608 and hsa-miR-873-3p.	0.329
35652072	Frontiers in medicine	2022	Differentially Expressed Circular RNAs and Their Therapeutic Mechanism in Non-segmental Vitiligo Patients Treated With Methylprednisolone.		hsa_circRNA_103556 / circTFRC	hsa_circ_TFRC	TFRC	vitiligo	MONDO:0008661	vitiligo	down-regulated	Microarray	circTFRC (hsa_circRNA_103556) was reported as down-regulated after methylprednisolone treatment in vitiligo patients and annotated as ferroptosis-related. Predicted interacting miRNAs include hsa-miR-149-5p and hsa-miR-653-3p.	0.329
35652072	Frontiers in medicine	2022	Differentially Expressed Circular RNAs and Their Therapeutic Mechanism in Non-segmental Vitiligo Patients Treated With Methylprednisolone.		hsa_circRNA_104600 / circVDAC3	hsa_circ_VDAC3	VDAC3	vitiligo	MONDO:0008661	vitiligo	down-regulated	Microarray	circVDAC3 (hsa_circRNA_104600) was identified as down-regulated after methylprednisolone treatment in vitiligo patients and linked to the ferroptosis gene set by enrichment analysis. Predicted interacting miRNAs include hsa-miR-609 and hsa-miR-758-5p.	0.329
35654787	Cell death & disease	2022	CircSCAF8 promotes growth and metastasis of prostate cancer through the circSCAF8-miR-140-3p/miR-335-LIF pathway.	hsa_circ_0078367	circSCAF8	hsa_circ_SCAF8	SCAF8	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circSCAF8 is up-regulated in prostate cancer tissues and urine extracellular vesicles and promotes PCa cell proliferation, migration, invasion, and in vivo growth/metastasis. It acts as a ceRNA sponging miR-140-3p and miR-335 to upregulate LIF and activate the LIF-STAT3 pathway, and high circSCAF8 expression predicts poorer progression-free survival."	0.8868
35655258	Journal of experimental & clinical cancer research : CR	2022	CircCEMIP promotes anoikis-resistance by enhancing protective autophagy in prostate cancer cells.	hsa_circ_0004585	circCEMIP / circ_0004585	hsa_circ_CEMIP	CEMIP	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circ_0004585 (circCEMIP; hsa_circ_0004585), derived from the CEMIP gene, is upregulated in prostate cancer tissues and anoikis-resistant PCa cells and mainly localizes to the cytoplasm. It promotes invasion/metastasis and anoikis-resistance by acting as a ceRNA that sponges miR-1248 to increase TM9SF4, which suppresses mTOR phosphorylation and enhances protective autophagy."	0.8007
35655923	Journal of immunology research	2022	Potential Value of Circular RNA circTBC1D4 in Gastrointestinal Stromal Tumors.	hsa_circ_0002917	circTBC1D4 / hsa-circRNA-101273	hsa_circ_TBC1D4	TBC1D4	gastrointestinal stromal tumor / GIST	MONDO:0011719	gastrointestinal stromal tumor	up-regulated	RT-qPCR; Microarray	"circTBC1D4 (hsa-circ-0002917) is up-regulated in GIST and promotes tumor progression. It functions through a ceRNA axis involving miR-590-5p and the downstream target PLN, supported by siRNA knockdown and qRT-PCR validation in GIST-882 cells."	0.3213
35655923	Journal of immunology research	2022	Potential Value of Circular RNA circTBC1D4 in Gastrointestinal Stromal Tumors.	hsa_circ_0039216 	hsa-circRNA-101802	hsa_circ_GPT2	GPT2	gastrointestinal stromal tumor / GIST	MONDO:0011719	gastrointestinal stromal tumor	unknown	Microarray	hsa-circ-0039216 is implicated in GIST through a predicted ceRNA axis with hsa-miR-338-3p and ATP1A2 constructed from microarray and in-silico target predictions. This circRNA was not experimentally validated by qRT-PCR in the paper.	0.1768
35656024	Oxidative medicine and cellular longevity	2022	Upregulated circTMEM59 Inhibits Cell Growth and Metastasis by miR-668-3p/ID4 Axis in Colorectal Cancer.	hsa_circ_0012634	circTMEM59	hsa_circ_TMEM59	TMEM59	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	"circTMEM59 (hsa_circ_0012634) is down-regulated in colorectal cancer tissues and CRC cell lines and its low level correlates with worse OS/DFS. Functionally, circTMEM59 suppresses proliferation, cell-cycle progression, migration/invasion and promotes apoptosis in vitro and in nude-mouse xenograft/metastasis models. Mechanistically, it acts as a ceRNA that sponges miR-668-3p to increase ID4 expression (circTMEM59/miR-668-3p/ID4 axis)."	0.8684
35656182	Iranian journal of basic medical sciences	2022	Comprehensive competitive endogenous RNA network analysis reveals EZH2-related axes and prognostic biomarkers in hepatocellular carcinoma.	hsa_circ_0072088		hsa_circ_ASB15	ASB15	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	unknown	Microarray	"hsa_circ_0072088 was included in the constructed four-component ceRNA network as part of an axis with ASB15 and hsa-miR-1251-5p, but this axis had no connection to the rest of the network and was removed. No experimental functional validation or clinical association was reported for this circRNA in HCC."	0.1768
35656182	Iranian journal of basic medical sciences	2022	Comprehensive competitive endogenous RNA network analysis reveals EZH2-related axes and prognostic biomarkers in hepatocellular carcinoma.	hsa_circ_0007456	hsa_circ _0007456			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	unknown	Microarray	hsa_circ_0007456 was identified as a hub circRNA in the constructed HCC ceRNA network and was predicted to interact with hsa-miR-182-5p. The study did not provide experimental validation or direct functional assays for this circRNA.	0.1768
35656182	Iranian journal of basic medical sciences	2022	Comprehensive competitive endogenous RNA network analysis reveals EZH2-related axes and prognostic biomarkers in hepatocellular carcinoma.	hsa_circ_0040705				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	unknown	Microarray	"hsa_circ_0040705 was identified bioinformatically as a putative ceRNA competitor involved in EZH2-related axes (via hsa-miR-527 or hsa-miR-518a-5p) in HCC. No experimental validation, direction of dysregulation, or clinical prognostic association was reported for this circRNA."	0.1768
35656182	Iranian journal of basic medical sciences	2022	Comprehensive competitive endogenous RNA network analysis reveals EZH2-related axes and prognostic biomarkers in hepatocellular carcinoma.	hsa_circ_0069104				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	unknown	Microarray	"hsa_circ_0069104 was identified bioinformatically as a putative ceRNA competitor involved in EZH2-related axes (via hsa-miR-527 or hsa-miR-518a-5p) in HCC. No experimental validation, direction of dysregulation, or clinical prognostic association was reported for this circRNA."	0.1768
35659274	Journal of experimental & clinical cancer research : CR	2022	Circ_0004087 interaction with SND1 promotes docetaxel resistance in prostate cancer by boosting the mitosis error correction mechanism.	hsa_circ_0004087	circ_0004087	hsa_circ_CDYL2	CDYL2	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; RNA-seq; Microarray	"circ_0004087 is upregulated in prostate cancer and promotes docetaxel resistance. It localizes mainly in the nucleus and binds SND1, enhancing SND1-mediated MYB transactivation to increase BUB1 expression, which strengthens CPC-dependent mitosis error correction and reduces DTX-induced apoptosis."	0.8293
35662705	Frontiers in pharmacology	2022	Quercetin Inhibits Tumorigenesis of Colorectal Cancer Through Downregulation of hsa_circ_0006990.	hsa_circ_0006990		hsa_circ_VAPA	VAPA	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"In CRC cells (HCT116 and LoVo) under M2-TAM co-culture conditions, hsa_circ_0006990 is upregulated and promotes tumorigenic behaviors. Quercetin inhibits CRC proliferation, migration and invasion and promotes apoptosis partly by downregulating hsa_circ_0006990. Mechanistically, hsa_circ_0006990 sponges miR-132-3p and miR-342-3p to regulate MUC13 and E2F1, forming ceRNA axes involved in quercetin-mediated CRC suppression."	0.5627
35663593	"Open medicine (Warsaw, Poland)"	2022	circRNF20 aggravates the malignancy of retinoblastoma depending on the regulation of miR-132-3p/PAX6 axis.	hsa_circ_0087784	circRNF20	hsa_circ_RNF20	RNF20	retinoblastoma / RB	MONDO:0008380	retinoblastoma	up-regulated	RT-qPCR	"circRNF20 is up-regulated in retinoblastoma tissues/cells and is associated with advanced TNM stage and worse overall survival. Functionally, circRNF20 promotes RB cell proliferation, migration/invasion and EMT while inhibiting apoptosis, and it enhances tumor growth in a xenograft model. Mechanistically, circRNF20 sponges miR-132-3p to upregulate PAX6, and circRNF20 is also present in patient serum-derived exosomes that can enhance malignant phenotypes in RB cells."	0.8616
35663842	Regenerative therapy	2022	CircRNA PVT1 modulated cell migration and invasion through Epithelial-Mesenchymal Transition (EMT) mediation in gastric cancer through miR-423-5p/Smad3 pathway.		circRNA PVT1 / circPVT1	hsa_circ_PVT1	PVT1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"CircPVT1 is up-regulated in gastric cancer cell lines and promotes viability, migration, invasion and EMT. Mechanistically, it acts as a ceRNA that sponges miR-423-5p to relieve repression of SMAD3, increasing Smad3 phosphorylation and activating Smad3 signaling."	0.5607
35668527	Molecular cancer	2022	CircVAPA promotes small cell lung cancer progression by modulating the miR-377-3p and miR-494-3p/IGF1R/AKT axis.	hsa_circ_0006990	CircVAPA	hsa_circ_VAPA	VAPA	small cell lung cancer / SCLC	MONDO:0008433	small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"circVAPA (hsa_circ_0006990), derived from VAPA, is upregulated in SCLC tissues, serum, and SCLC cell lines. It mainly localizes to the cytoplasm and promotes SCLC proliferation/viability and tumor growth by sponging miR-377-3p and miR-494-3p to increase IGF1R and activate the PI3K/AKT signaling axis, and its depletion enhances response to the IGF1R inhibitor BMS-536924."	0.8737
35668777	Evidence-based complementary and alternative medicine : eCAM	2022	Circ-GTF2I/miR-590-5p Axis Aggravates Myocardial Ischemia-Reperfusion Injury by Regulating Kelch Repeat and BTB Domain-Containing Protein 7.		circ-GTF2I 	rno_circ_GTF2I	GTF2I	myocardial ischemia/reperfusion injury	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR	"circ-GTF2I is up-regulated in rat MIRI and hypoxia/reoxygenation cardiomyocyte models. It aggravates myocardial ischemia-reperfusion injury by acting as a ceRNA that sponges miR-590-5p, thereby increasing KBTBD7 and promoting inflammation and cardiomyocyte apoptosis (Bax/Cyt-c up, Bcl-2 down)."	0.5634
35669238	Journal of oncology	2022	Hsa_circ_0000994 Inhibits Pancreatic Cancer Progression by Clearing Immune-Related miR-27a and miR-27b.	hsa_circ_0000994				Pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	down-regulated	RT-qPCR	"Hsa_circ_0000994 is down-regulated in pancreatic cancer tissues and cell lines and functions as a tumor suppressor. It inhibits proliferation, migration and invasion and promotes apoptosis, at least partly by sponging miR-27a and miR-27b, as supported by luciferase and rescue assays."	0.7369
35674190	Molecular medicine reports	2022	Circ_0006174 promotes the malignancy of colorectal cancer cell via the miR_1205/CCBE1/Wnt pathway.	hsa_circ_0006174	circ_0006174 / circ_104852	hsa_circ_RAD23B	RAD23B	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circ_0006174 is up-regulated in colorectal cancer tissues and cell lines and functions as an oncogenic circRNA. It mainly localizes in the cytoplasm and promotes proliferation, migration/invasion and lung metastasis while inhibiting apoptosis by sponging miR-1205 to increase CCBE1 and activate Wnt pathway-related proteins (e.g., c-Myc and cyclin D1)."	0.6975
35678490	Innate immunity	2022	Circ_0062491 alleviates LPS-induced apoptosis and inflammation in periodontitis by regulating miR-498/SOCS6 axis.	hsa_circ_0062491	Circ_0062491	hsa_circ_MIR650	MIR650	periodontitis	MONDO:0005076	periodontitis	down-regulated	RT-qPCR	circ_0062491 is down-regulated in periodontitis PDL tissues and in LPS-stimulated PDLCs. Its overexpression protects PDLCs by reducing apoptosis and inflammatory cytokine production via a ceRNA mechanism (circ_0062491 sponges miR-498 to relieve repression of SOCS6).	0.7032
35680981	Scientific reports	2022	The integrative analysis of competitive endogenous RNA regulatory networks in osteoporosis.	hsa_circ_0028877		hsa_circ_COX6A1	COX6A1	Osteoporosis / OP	MONDO:0005298	osteoporosis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0028877 (also referred to as hsa_circR_0028877) is up-regulated in osteoporosis-related circRNA microarray data and is significantly correlated with osteogenesis markers in human cancellous bone. The study proposes a ceRNA mechanism where hsa_circR_0028877 sponges hsa-miR-1273f to positively relate with CAMK2A and DIRAS2 expression, forming two OP-associated axes."	0.4032
35680981	Scientific reports	2022	The integrative analysis of competitive endogenous RNA regulatory networks in osteoporosis.	hsa_circ_0082916		hsa_circ_FASTK	FASTK	Osteoporosis / OP	MONDO:0005298	osteoporosis	up-regulated	RT-qPCR; Microarray	hsa_circ_0082916 (also referred to as hsa_circR_0082916) is up-regulated in OP-related microarray data and its expression in human cancellous bone tissue is significantly correlated with osteogenesis indicators. The study does not specify a validated downstream miRNA/mRNA axis for this circRNA.	0.4032
35680981	Scientific reports	2022	The integrative analysis of competitive endogenous RNA regulatory networks in osteoporosis.	hsa_circ_0030712		hsa_circ_DOCK9	DOCK9	Osteoporosis / OP	MONDO:0005298	osteoporosis	up-regulated	RT-qPCR; Microarray	hsa_circ_0030712 is up-regulated in OP-related microarray data and shows significant correlation with osteogenesis markers in human bone tissues. No specific miRNA/mRNA regulatory axis is experimentally established for this circRNA in the paper.	0.4032
35682879	International journal of molecular sciences	2022	"CircSRSF4 Enhances Proliferation, Invasion, and Migration to Promote the Progression of Osteosarcoma via Rac1."	hsa_circ_0006602	circSRSF4	hsa_circ_SRSF4	SRSF4	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; RNA-seq	"circSRSF4 (hsa_circ_0006602), derived from the SRSF4 gene, is up-regulated in osteosarcoma tissues and cell lines. It promotes osteosarcoma proliferation, migration, invasion, and xenograft tumor growth by acting as a ceRNA sponge for miR-224, thereby de-repressing Rac1 expression."	0.8439
35685074	Translational pediatrics	2022	Bioinformatic analysis of dysregulated circular RNAs in pediatric pulmonary hypertension linked congenital heart disease.		circ_005372 / 005372 / hsa_circ_005372 / hsa_circRNA_005372			pulmonary arterial hypertension / PAH	MONDO:0015924	pulmonary arterial hypertension	up-regulated	RT-qPCR; Microarray	"hsa_circ_005372 is up-regulated in plasma from pediatric CHD-PAH patients versus PAH-free CHD controls. The study predicts that it binds multiple miRNAs and participates in a circRNA_miRNA_mRNA regulatory network, with enrichment signals including oxidative phosphorylation and tight junction pathways."	0.3858
35685074	Translational pediatrics	2022	Bioinformatic analysis of dysregulated circular RNAs in pediatric pulmonary hypertension linked congenital heart disease.		circ_003416 / hsa_circ_003416			pulmonary arterial hypertension / PAH	MONDO:0015924	pulmonary arterial hypertension	down-regulated	RT-qPCR; Microarray	"hsa_circ_003416 is down-regulated in plasma from pediatric CHD-PAH patients versus PAH-free CHD controls. The study predicts that it binds multiple miRNAs and participates in a circRNA_miRNA_mRNA regulatory network, with enrichment signals including oxidative phosphorylation and tight junction pathways."	0.3858
35685832	International journal of genomics	2022	Identification of Novel circRNA-Based ceRNA Network Involved in the Pathogenesis of Gastric Cancer.	hsa_circ_0000384	circMRPS35	hsa_circ_MRPS35	MRPS35	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000384 (circMRPS35) is up-regulated in gastric cancer tissues and is proposed to promote GC progression by acting as a ceRNA that sponges multiple miRNAs (e.g., has-miR-30a-5p/has-miR-30c-5p, has-miR-326), thereby increasing expression of hub oncogenic genes such as TFDP1, KRAS, MET and LMNB1."	0.4032
35685832	International journal of genomics	2022	Identification of Novel circRNA-Based ceRNA Network Involved in the Pathogenesis of Gastric Cancer.	hsa_circ_0000043	circPUM1	hsa_circ_PUM1	PUM1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000043 (circPUM1) is up-regulated in gastric cancer tissues and is implicated in a ceRNA axis where it mediates has-miR-326 to positively regulate KRAS, contributing to increased proliferation and invasion in GC."	0.4032
35686126	Frontiers in immunology	2022	Circular RNA circNUP214 Modulates the T Helper 17 Cell Response in Patients With Rheumatoid Arthritis.	hsa_circ_0089172	circNUP214	hsa_circ_NUP214	NUP214	rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"circNUP214 is up-regulated in PBMCs from rheumatoid arthritis patients and is mainly cytoplasmic. It promotes Th17/IL-17A responses by regulating IL-23R, at least partly by acting as a ceRNA sponge for miR-125a-3p, and shows potential diagnostic value by ROC analysis."	0.8195
35686503	Gut and liver	2022	Circ_0081143 Contributes to Gastric Cancer Malignant Development and Doxorubicin Resistance by Elevating the Expression of YES1 by Targeting mziR-129-2-3p.	hsa_circ_0081143	circ_0081143	hsa_circ_COL1A2	COL1A2	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_0081143 (from COL1A2) is up-regulated in gastric cancer, especially doxorubicin-resistant tumors and cells, and promotes malignant behaviors and doxorubicin resistance. Mechanistically, it sponges miR-129-2-3p to derepress YES1 (miR-129-2-3p/YES1 axis). Inhibiting circ_0081143 sensitizes cells to doxorubicin and suppresses xenograft tumor growth."	0.6825
35687899	Aging	2022	Hsa_circ_0063804 enhances ovarian cancer cells proliferation and resistance to cisplatin by targeting miR-1276/CLU axis.	hsa_circ_0063804	circ_0063804	hsa_circ_CELSR1	CELSR1	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circ_0063804 is up-regulated in ovarian cancer and its high expression is associated with worse survival. Functionally, it promotes proliferation, suppresses apoptosis, and increases cisplatin resistance by sponging miR-1276 to relieve repression of CLU."	0.7985
35690612	Cell death discovery	2022	CircRFWD3 promotes HNSCC metastasis by modulating miR-27a/b/PPARgamma signaling.	hsa_circ_0004519	hsa_circ_101877	hsa_circ_RFWD3	RFWD3	Head and neck squamous cell carcinoma / HNSCC	MONDO:0010150	head and neck squamous cell carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circRFWD3 is upregulated in HNSCC and mainly localized in the cytoplasm. It promotes HNSCC migration/invasion and metastasis by sponging miR-27a/miR-27b to upregulate PPARgamma and activate the NF-kappaB/MMP13 axis, and its high expression predicts worse overall survival."	0.8981
35690768	Respiratory research	2022	Comprehensive identification of RNA transcripts and construction of RNA network in chronic obstructive pulmonary disease.		CircFCHO2	hsa_circ_FCHO2	FCHO2	chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR; RNA-seq	"CircFCHO2 is significantly up-regulated in peripheral blood from COPD patients. The study included CircFCHO2 in a predicted circRNA_miRNA_mRNA (ceRNA) network, suggesting a potential miRNA-sponge regulatory role in COPD."	0.4032
35690768	Respiratory research	2022	Comprehensive identification of RNA transcripts and construction of RNA network in chronic obstructive pulmonary disease.		circMBOAT2	hsa_circ_MBOAT2	MBOAT2	chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR; RNA-seq	"circMBOAT2 is significantly up-regulated in peripheral blood from COPD patients. It was included in a predicted circRNA_miRNA_mRNA (ceRNA) network, implying potential miRNA-sponge regulation in COPD."	0.4032
35690768	Respiratory research	2022	Comprehensive identification of RNA transcripts and construction of RNA network in chronic obstructive pulmonary disease.		circPTPN22	hsa_circ_PTPN22	PTPN22	chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR; RNA-seq	"circPTPN22 is significantly up-regulated in peripheral blood from COPD patients. It was used to construct a predicted circRNA_miRNA_mRNA network, indicating a potential ceRNA (miRNA sponge) role in COPD."	0.4032
35690768	Respiratory research	2022	Comprehensive identification of RNA transcripts and construction of RNA network in chronic obstructive pulmonary disease.		circTBC1D22A	hsa_circ_TBC1D22A	TBC1D22A	chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR; RNA-seq	"circTBC1D22A is significantly up-regulated in peripheral blood from COPD patients. It was incorporated into a predicted circRNA_miRNA_mRNA ceRNA network, suggesting potential miRNA-sponge regulation in COPD."	0.4032
35690768	Respiratory research	2022	Comprehensive identification of RNA transcripts and construction of RNA network in chronic obstructive pulmonary disease.		cirCOPDADM			chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR; RNA-seq	cirCOPDADM is significantly up-regulated in peripheral blood from COPD patients. It was included among six validated circRNAs used to build a predicted circRNA_miRNA_mRNA ceRNA network in COPD.	0.4032
35690768	Respiratory research	2022	Comprehensive identification of RNA transcripts and construction of RNA network in chronic obstructive pulmonary disease.		circCKAP5	hsa_circ_CKAP5	CKAP5	chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR; RNA-seq	circCKAP5 is significantly up-regulated in peripheral blood from COPD patients. It was one of six validated circRNAs used for constructing a predicted circRNA_miRNA_mRNA (ceRNA) network in COPD.	0.4032
35698305	Journal of clinical laboratory analysis	2022	Hsa_circ_0001550 facilitates colorectal cancer progression through mediating microRNA-4262/nuclear casein kinase and cyclin-dependent kinase substrate 1 cascade.	hsa_circ_0001550	Circ_0001550	hsa_circ_RARS	RARS	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"hsa_circ_0001550 is up-regulated in colorectal cancer and acts as an oncogenic circRNA. It sponges miR-4262 to up-regulate the downstream target NUCKS1, thereby promoting proliferation, migration/invasion, stemness, and in vivo xenograft tumor growth while inhibiting apoptosis."	0.7792
35700140	Aging	2022	The circular RNA hsa_circ_0003091 regulates sepsis-induced lung injury by sponging the miR-149/Smad2 axis.	hsa_circ_0003091	circ_0015268			sepsis-induced acute lung injury	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0003091/mmu_circ_0015268 is up-regulated in sepsis-induced ALI and promotes lung inflammation, apoptosis, and endothelial activation. Mechanistically, it acts as a ceRNA by sponging miR-149, thereby increasing Smad2 expression; silencing it mitigates LPS-induced lung injury."	0.6835
35700140	Aging	2022	The circular RNA hsa_circ_0003091 regulates sepsis-induced lung injury by sponging the miR-149/Smad2 axis.	mmu_circ_0015268	circ_0015268			sepsis-induced acute lung injury	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0003091/mmu_circ_0015268 is up-regulated in sepsis-induced ALI and promotes lung inflammation, apoptosis, and endothelial activation. Mechanistically, it acts as a ceRNA by sponging miR-149, thereby increasing Smad2 expression; silencing it mitigates LPS-induced lung injury."	0.6835
35700516	Aging	2022	CircSOX9 acts as a molecular sponge of miR-485-3p to promote the progression of nasopharyngeal carcinoma.		circSOX9	hsa_circ_SOX9	SOX9	nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; Microarray	"circSOX9 is up-regulated in nasopharyngeal carcinoma and promotes malignant phenotypes (proliferation, invasion/migration, EMT and xenograft growth). Mechanistically, it functions as a ceRNA that sponges miR-485-3p to relieve repression of SOX9, forming a circSOX9/miR-485-3p/SOX9 axis associated with poor prognosis and recurrence."	0.866
35703190	Bioengineered	2022	Exosomal circRNA FNDC3B promotes the progression of esophageal squamous cell carcinoma by sponging miR-490-5p and regulating thioredoxin reductase 1 expression.	hsa_circ_0006948	circRNA FNDC3B / circ_0006948 	hsa_circ_FNDC3B	FNDC3B	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"circFNDC3B (hsa_circ_0006948) is up-regulated in ESCC tissues/cells and ESCC-derived exosomes and promotes malignant phenotypes (proliferation, migration/invasion, glycolysis) and xenograft growth. Mechanistically, it is delivered via exosomes and functions as a ceRNA by sponging miR-490-5p, thereby increasing TXNRD1 expression. High circFNDC3B is associated with advanced stage/lymph node invasion, diagnostic value (ROC AUC 0.9043), and poorer overall survival."	0.8921
35706804	Translational cancer research	2022	Bioinformatics analysis of potential glioblastoma circular RNA sponge network.	hsa_circ_0000219		hsa_circ_FAM188A	FAM188a	glioblastoma / GBM	MONDO:0018177	glioblastoma	down-regulated	RNA-seq; Microarray	"hsa_circ_0000219 was identified as a common down-regulated circRNA in GBM across multiple GEO datasets and incorporated into a predicted circRNA_miRNA_mRNA sponge network. It is predicted to interact with hsa-miR-1248 and may affect downstream genes (e.g., RNF11 and others) based on database screening, but lacks experimental validation."	0.2465
35706804	Translational cancer research	2022	Bioinformatics analysis of potential glioblastoma circular RNA sponge network.	hsa_circ_0070700		hsa_circ_ANK2	ANK2	glioblastoma / GBM	MONDO:0018177	glioblastoma	down-regulated	RNA-seq; Microarray	"hsa_circ_0070700 was identified as a common down-regulated circRNA in GBM from GEO datasets and incorporated into a predicted ceRNA sponge network. It is predicted to bind hsa-miR-1248, with downstream mRNA targets inferred from database screening, but no wet-lab validation was performed."	0.2465
35706804	Translational cancer research	2022	Bioinformatics analysis of potential glioblastoma circular RNA sponge network.	hsa_circ_0001073		hsa_circ_ACVR2A	ACVR2A	glioblastoma / GBM	MONDO:0018177	glioblastoma	down-regulated	RNA-seq; Microarray	"hsa_circ_0001073 was identified as a common down-regulated circRNA in GBM and used to construct a predicted circRNA_miRNA_mRNA sponge network. It is predicted to bind hsa-miR-1290 and thereby relate to downstream mRNAs selected via TCGA expression/survival filtering, but the network is not experimentally validated."	0.2465
35707381	BioMed research international	2022	The Application of circRNA-016901 in Improving the Diagnostic Accuracy of Osteoarthritis.		circRNA-016901			osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	circRNA-016901 is specifically up-regulated in plasma from osteoarthritis patients compared with healthy controls and is not increased in rheumatoid arthritis or osteonecrosis. Plasma circRNA-016901 shows diagnostic value (ROC) for distinguishing OA from RA/ON/HC and correlates with OA severity (KL grade) and treatment response (decreases after treatment).	0.4187
35707741	International journal of general medicine	2022	Circular RNAs Hsa_circ_101555 and Hsa_circ_008068 as Diagnostic Biomarkers for Early-Stage Lung Adenocarcinoma.		hsa_circ_101555	hsa_circ_CSNK1G1	CSNK1G1	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_101555 is significantly up-regulated in stage I LUAD tumour tissues and in circulating plasma compared with controls. It shows diagnostic utility for early-stage LUAD based on ROC/AUC analysis and correlates with tumour differentiation, tumour size and CEA levels."	0.5963
35707741	International journal of general medicine	2022	Circular RNAs Hsa_circ_101555 and Hsa_circ_008068 as Diagnostic Biomarkers for Early-Stage Lung Adenocarcinoma.		hsa_circ_008068	hsa_circ_KATNAL1	KATNAL1	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_008068 is significantly up-regulated in stage I LUAD tumour tissues and in circulating plasma compared with controls. It has diagnostic value for early-stage LUAD based on ROC/AUC analysis and is associated with clinicopathologic indicators including tumour differentiation, tumour size and CEA."	0.5963
35710947	Communications biology	2022	MALAT1-dependent hsa_circ_0076611 regulates translation rate in triple-negative breast cancer.	hsa_circ_0076611	circ_0076611	hsa_circ_VEGFA	VEGFA	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; ISH	"In TNBC/BLBC, hsa_circ_0076611 (from VEGFA exon 7) binds many mRNAs (including VEGFA and MYC) and promotes proliferation and migration. It enhances translation initiation by facilitating interactions between target mRNAs and eIF4F components (e.g., EIF4B/EIF4G), increasing target protein output and contributing to aggressive tumor features; it is also detectable in exosomes and patient serum."	0.8891
35712476	Frontiers in oncology	2022	Hsa_circ_0046523 Mediates an Immunosuppressive Tumor Microenvironment by Regulating MiR-148a-3p/PD-L1 Axis in Pancreatic Cancer.	hsa_circ_0046523		hsa_circ_TBCD	TBCD	pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"hsa_circ_0046523 is upregulated in pancreatic cancer and promotes malignant phenotypes (proliferation, migration, invasion). It acts as a miR-148a-3p sponge to increase PD-L1 expression, shaping an immunosuppressive microenvironment characterized by reduced CD4+/CD8+ T cells, increased Tregs, and CD8+ T-cell apoptosis/exhaustion. High hsa_circ_0046523 expression is associated with advanced clinicopathological features and poorer overall survival."	0.7357
35712504	Frontiers in oncology	2022	circDNMT1 Promotes Malignant Progression of Gastric Cancer Through Targeting miR-576-3p/Hypoxia Inducible Factor-1 Alpha Axis.	hsa_circ_0049224	circDNMT1	hsa_circ_DNMT1	DNMT1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circDNMT1 (Hsa_circ_0049224), derived from DNMT1, is up-regulated in gastric cancer tissues and cell lines and mainly localized in the cytoplasm. It promotes GC proliferation, migration, invasion and glycolysis by sponging miR-576-3p to derepress HIF-1alpha, enhancing tumor growth and metastasis in xenograft models, and high circDNMT1 is associated with poorer overall survival."	0.8521
35716032	Cell proliferation	2022	CircHIPK3 prevents chondrocyte apoptosis and cartilage degradation by sponging miR-30a-3p and promoting PON2.		circHIPK3 / hsa_circRNA_000284	hsa_circ_HIPK3	HIPK3	Osteoarthritis / OA	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR	"circHIPK3 is down-regulated in osteoarthritis cartilage and chondrocytes. It suppresses ROS accumulation and mitochondria-mediated apoptosis and protects ECM homeostasis by sponging miR-30a-3p to maintain PON2 expression, thereby alleviating cartilage degradation in the DMM mouse model."	0.7981
35716032	Cell proliferation	2022	CircHIPK3 prevents chondrocyte apoptosis and cartilage degradation by sponging miR-30a-3p and promoting PON2.	mmu_circ_0001052	circHIPK3	mmu_circ_HIPK3	HIPK3	Osteoarthritis / OA	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR	"circHIPK3 is down-regulated in osteoarthritis cartilage and chondrocytes. It suppresses ROS accumulation and mitochondria-mediated apoptosis and protects ECM homeostasis by sponging miR-30a-3p to maintain PON2 expression, thereby alleviating cartilage degradation in the DMM mouse model."	0.7981
35717572	Cell journal	2022	"Hsa_circ_0006427 Suppresses Multiplication, Migration and Invasion of Non-Small Cell Lung Cancer Cells through miR-346/VGLL4 Pathway."	hsa_circ_0006427	circ_0006427			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"circ_0006427 is down-regulated in NSCLC tissues/cells and acts as a tumor suppressor by inhibiting proliferation, migration, invasion and EMT. It functions as a ceRNA that sponges miR-346, thereby relieving repression of VGLL4 and suppressing NSCLC progression."	0.6777
35720103	Frontiers in neurology	2022	Circular RNA FUNDC1 for Prediction of Acute Phase Outcome and Long-Term Survival of Acute Ischemic Stroke.		circular RNA FUNDC1 (circFUNDC1) / circFUNDC1	hsa_circ_FUNDC1	FUNDC1	ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR	"circFUNDC1 is elevated in plasma of AIS patients across TOAST subtypes and is higher in END than non-END cases. Higher circFUNDC1 is associated with greater neurological deficit scores and predicts shorter 18-month post-stroke survival, supporting its potential as an admission blood biomarker for acute-phase outcome and long-term prognosis."	0.5339
35721315	Frontiers in molecular neuroscience	2022	DNA Methylation-Related circRNA_0116449 Is Involved in Lipid Peroxidation in Traumatic Brain Injury.	hsa_circ_0116449	circRNA_0116449 / circ-SFI1	hsa_circ_SFI1	SFI1	traumatic brain injury / TBI	MONDO:0858950	traumatic brain injury	down-regulated	RT-qPCR; Microarray	"circ_0116449 (circ-SFI1) is down-regulated with increasing TBI severity in human blood and correlates positively with GCS. Functionally, circ_0116449 protects neurons by promoting proliferation and reducing apoptosis/ROS, and mechanistically acts as a ceRNA sponging miR-142-3p to upregulate NR1D2, contributing to suppression of lipid peroxidation in vitro and in vivo."	0.6283
35722302	Frontiers in microbiology	2022	The Cellular and Viral circRNAs Induced by Fowl Adenovirus Serotype 4 Infection.		ggacirc_011603	gga_circ_NUMB	NUMB	Fowl adenovirus infection	MONDO:0043479	adenoviridae infectious disease	up-regulated	RT-qPCR; RNA-seq	"ggacirc_011603 is a host (chicken) circRNA whose abundance increases in LMH cells upon FAdV-4 infection, supported by RNA-seq and semiquantitative divergent-primer RT-PCR validation."	0.4358
35722302	Frontiers in microbiology	2022	The Cellular and Viral circRNAs Induced by Fowl Adenovirus Serotype 4 Infection.		ggacirc_013250	gga_circ_F10 alpha	F10 alpha	Fowl adenovirus infection	MONDO:0043479	adenoviridae infectious disease	up-regulated	RT-qPCR; RNA-seq	"ggacirc_013250 is upregulated in LMH cells after FAdV-4 infection, supported by RNA-seq and semiquantitative divergent-primer RT-PCR validation."	0.4358
35722302	Frontiers in microbiology	2022	The Cellular and Viral circRNAs Induced by Fowl Adenovirus Serotype 4 Infection.		ggacirc_008173			Fowl adenovirus infection	MONDO:0043479	adenoviridae infectious disease	up-regulated	RT-qPCR; RNA-seq	"ggacirc_008173 is a differentially expressed host circRNA that increases after FAdV-4 infection in LMH cells, validated by RNA-seq and semiquantitative divergent-primer RT-PCR."	0.4358
35722302	Frontiers in microbiology	2022	The Cellular and Viral circRNAs Induced by Fowl Adenovirus Serotype 4 Infection.		ggacirc_009693	gga_circ_ERI3	ERI3	Fowl adenovirus infection	MONDO:0043479	adenoviridae infectious disease	up-regulated	RT-qPCR; RNA-seq	"ggacirc_009693 is upregulated in LMH cells upon FAdV-4 infection, supported by RNA-seq and semiquantitative divergent-primer RT-PCR validation."	0.4358
35722302	Frontiers in microbiology	2022	The Cellular and Viral circRNAs Induced by Fowl Adenovirus Serotype 4 Infection.		ggacirc_022182			Fowl adenovirus infection	MONDO:0043479	adenoviridae infectious disease	up-regulated	RT-qPCR; RNA-seq	"ggacirc_022182 is upregulated in LMH cells following FAdV-4 infection, validated by RNA-seq and semiquantitative divergent-primer RT-PCR."	0.4358
35722302	Frontiers in microbiology	2022	The Cellular and Viral circRNAs Induced by Fowl Adenovirus Serotype 4 Infection.		ggacirc_008669	gga_circ_CEP76	CEP76	Fowl adenovirus infection	MONDO:0043479	adenoviridae infectious disease	down-regulated	RT-qPCR; RNA-seq	"ggacirc_008669 is downregulated in LMH cells after FAdV-4 infection, supported by RNA-seq and semiquantitative divergent-primer RT-PCR validation."	0.4358
35722302	Frontiers in microbiology	2022	The Cellular and Viral circRNAs Induced by Fowl Adenovirus Serotype 4 Infection.		ggacirc_024898	gga_circ_GCH1	GCH1	Fowl adenovirus infection	MONDO:0043479	adenoviridae infectious disease	down-regulated	RT-qPCR; RNA-seq	"ggacirc_024898 is downregulated in LMH cells following FAdV-4 infection, supported by RNA-seq and semiquantitative divergent-primer RT-PCR validation."	0.4358
35722302	Frontiers in microbiology	2022	The Cellular and Viral circRNAs Induced by Fowl Adenovirus Serotype 4 Infection.		ggacirc_022382	gga_circ_C-factor-like	C-factor-like	Fowl adenovirus infection	MONDO:0043479	adenoviridae infectious disease	down-regulated	RT-qPCR; RNA-seq	"ggacirc_022382 is downregulated in LMH cells after FAdV-4 infection, supported by RNA-seq and semiquantitative divergent-primer RT-PCR validation."	0.4358
35722302	Frontiers in microbiology	2022	The Cellular and Viral circRNAs Induced by Fowl Adenovirus Serotype 4 Infection.		ggacirc_014774	gga_circ_MORC4	MORC4	Fowl adenovirus infection	MONDO:0043479	adenoviridae infectious disease	down-regulated	RT-qPCR; RNA-seq	"ggacirc_014774 is downregulated in LMH cells after FAdV-4 infection, supported by RNA-seq and semiquantitative divergent-primer RT-PCR validation."	0.4358
35722302	Frontiers in microbiology	2022	The Cellular and Viral circRNAs Induced by Fowl Adenovirus Serotype 4 Infection.		ggacirc_002521			Fowl adenovirus infection	MONDO:0043479	adenoviridae infectious disease	down-regulated	RT-qPCR; RNA-seq	"ggacirc_002521 is downregulated in LMH cells upon FAdV-4 infection, supported by RNA-seq and semiquantitative divergent-primer RT-PCR validation."	0.4358
35722302	Frontiers in microbiology	2022	The Cellular and Viral circRNAs Induced by Fowl Adenovirus Serotype 4 Infection.		FAdVcirc_023475 / pCirc_023475		pTP protein	Fowl adenovirus infection	MONDO:0043479	adenoviridae infectious disease	up-regulated	RT-qPCR; RNA-seq	FAdVcirc_023475 is a FAdV-4-derived circRNA whose level increases during infection and whose overexpression promotes FAdV-4 replication in LMH cells (increased Fiber 2 protein and virus titer).	0.5871
35722302	Frontiers in microbiology	2022	The Cellular and Viral circRNAs Induced by Fowl Adenovirus Serotype 4 Infection.		FAdVcirc_020380 / pCirc_020380		pTP protein	Fowl adenovirus infection	MONDO:0043479	adenoviridae infectious disease	up-regulated	RT-qPCR; RNA-seq	"FAdVcirc_020380 increases during infection and promotes FAdV-4 replication when overexpressed in LMH cells, as evidenced by increased Fiber 2 protein and viral titers."	0.5871
35722302	Frontiers in microbiology	2022	The Cellular and Viral circRNAs Induced by Fowl Adenovirus Serotype 4 Infection.		FAdVcirc_029216 / pCirc_029216		pTP protein	Fowl adenovirus infection	MONDO:0043479	adenoviridae infectious disease	unknown	RT-qPCR; RNA-seq	"FAdVcirc_029216 is a viral circRNA with a temporal expression peak within 24 hpi and, when overexpressed, enhances FAdV-4 replication in LMH cells."	0.5871
35722302	Frontiers in microbiology	2022	The Cellular and Viral circRNAs Induced by Fowl Adenovirus Serotype 4 Infection.		FAdVcirc_027083 / pCirc_027083		ORF13	Fowl adenovirus infection	MONDO:0043479	adenoviridae infectious disease	up-regulated	RT-qPCR; RNA-seq	FAdVcirc_027083 shows a persistent upward expression trend during infection and promotes FAdV-4 replication upon overexpression in LMH cells.	0.5871
35722302	Frontiers in microbiology	2022	The Cellular and Viral circRNAs Induced by Fowl Adenovirus Serotype 4 Infection.		FAdVcirc_008682 / pCirc_008682		pTP protein	Fowl adenovirus infection	MONDO:0043479	adenoviridae infectious disease	unknown	RT-qPCR; RNA-seq	FAdVcirc_008682 peaks within 24 hpi and promotes FAdV-4 replication when overexpressed in LMH cells.	0.5871
35722302	Frontiers in microbiology	2022	The Cellular and Viral circRNAs Induced by Fowl Adenovirus Serotype 4 Infection.		FAdVcirc_013009		DNA pol protein	Fowl adenovirus infection	MONDO:0043479	adenoviridae infectious disease	up-regulated	RT-qPCR; RNA-seq	"FAdVcirc_013009 is a viral circRNA that increases during infection and is predicted to act as a miRNA sponge for gga-miR-7475-5p, potentially influencing CREBZF and LFNG involved in host responses to infection."	0.4761
35722302	Frontiers in microbiology	2022	The Cellular and Viral circRNAs Induced by Fowl Adenovirus Serotype 4 Infection.		FAdVcirc_011337		Penton base	Fowl adenovirus infection	MONDO:0043479	adenoviridae infectious disease	unknown	RT-qPCR; RNA-seq	FAdVcirc_011337 is a viral circRNA validated during infection that is predicted to target gga-miR-7475-5p and may influence CREBZF/LFNG linked to host responses to infection.	0.4761
35722302	Frontiers in microbiology	2022	The Cellular and Viral circRNAs Induced by Fowl Adenovirus Serotype 4 Infection.		FAdVcirc_012746		Hexon protein	Fowl adenovirus infection	MONDO:0043479	adenoviridae infectious disease	unknown	RT-qPCR; RNA-seq	FAdVcirc_012746 is a validated FAdV-4 circRNA whose expression peaks within 24 hpi (rises then falls) during infection in LMH cells; no specific functional effect on replication was reported for this circRNA.	0.437
35722302	Frontiers in microbiology	2022	The Cellular and Viral circRNAs Induced by Fowl Adenovirus Serotype 4 Infection.		FAdVcirc_007095		pTP protein	Fowl adenovirus infection	MONDO:0043479	adenoviridae infectious disease	unknown	RT-qPCR; RNA-seq	FAdVcirc_007095 is a validated FAdV-4 circRNA with expression peaking within 24 hpi (rises then falls) in infected LMH cells; no direct effect on replication was reported for this circRNA.	0.437
35722302	Frontiers in microbiology	2022	The Cellular and Viral circRNAs Induced by Fowl Adenovirus Serotype 4 Infection.		FAdVcirc_016019		DNA pol protein	Fowl adenovirus infection	MONDO:0043479	adenoviridae infectious disease	unknown	RT-qPCR; RNA-seq	FAdVcirc_016019 is a validated FAdV-4 circRNA with expression peaking within 24 hpi (rises then falls) during infection in LMH cells; no specific replication-promoting function was reported for this circRNA.	0.437
35722400	Annals of translational medicine	2022	A ceRNA regulatory network in systemic lupus erythematosus and its molecular interplay with cancer.	hsa_circ_0027353				systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	unknown	RNA-seq	hsa_circ_0027353 was included as one of the circRNAs in the constructed SLE circRNA_miRNA_mRNA ceRNA network based on sequencing data and bioinformatics analyses. The paper did not report a specific validated downstream miRNA/mRNA axis or functional experiments for this circRNA.	0.1768
35722400	Annals of translational medicine	2022	A ceRNA regulatory network in systemic lupus erythematosus and its molecular interplay with cancer.	hsa_circ_0002173				systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	unknown	RNA-seq	hsa_circ_0002173 was part of the SLE ceRNA network constructed from sequencing data and public resources. No specific interaction axis or experimental functional validation for this circRNA was reported.	0.1768
35722400	Annals of translational medicine	2022	A ceRNA regulatory network in systemic lupus erythematosus and its molecular interplay with cancer.	hsa_circ_0002110				systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	unknown	RNA-seq	hsa_circ_0002110 was incorporated into the constructed SLE ceRNA network. The article did not provide circRNA-specific mechanistic/functional validation or named targets for this circRNA.	0.1768
35722400	Annals of translational medicine	2022	A ceRNA regulatory network in systemic lupus erythematosus and its molecular interplay with cancer.	hsa_circ_0045861				systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	unknown	RNA-seq	hsa_circ_0045861 was included among the circRNAs used to build the SLE ceRNA regulatory network. The study did not report circRNA-specific mechanistic targets or experimental validation for this circRNA.	0.1768
35722400	Annals of translational medicine	2022	A ceRNA regulatory network in systemic lupus erythematosus and its molecular interplay with cancer.	hsa_circ_0002003				systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	up-regulated	RNA-seq	"The study¡¯s ceRNA-network analysis included hsa_circ_0002003 and described it as up-regulated in SLE, suggesting a possible role in immune-response regulation. However, no specific miRNA/mRNA targets or experimental functional validation for hsa_circ_0002003 in SLE were reported in the paper."	0.1768
35722400	Annals of translational medicine	2022	A ceRNA regulatory network in systemic lupus erythematosus and its molecular interplay with cancer.	hsa_circ_0084691				systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	unknown	RNA-seq	hsa_circ_0084691 was one of the circRNAs incorporated into the SLE ceRNA network. The paper did not report a circRNA-specific target axis or functional assays for this circRNA.	0.1768
35722400	Annals of translational medicine	2022	A ceRNA regulatory network in systemic lupus erythematosus and its molecular interplay with cancer.	hsa_circ_0081828				systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	unknown	RNA-seq	hsa_circ_0081828 was used as a component of the constructed SLE ceRNA network. No circRNA-specific interaction partners or experimental validation were reported for this circRNA.	0.1768
35722400	Annals of translational medicine	2022	A ceRNA regulatory network in systemic lupus erythematosus and its molecular interplay with cancer.	hsa_circ_0073236				systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	unknown	RNA-seq	hsa_circ_0073236 was included in the SLE ceRNA network derived from differential-expression and target-prediction analyses. No specific target relationships or wet-lab validation were provided for this circRNA.	0.1768
35722400	Annals of translational medicine	2022	A ceRNA regulatory network in systemic lupus erythematosus and its molecular interplay with cancer.	hsa_circ_0066636				systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	unknown	RNA-seq	hsa_circ_0066636 was included as a DEcircRNA in the constructed SLE ceRNA network. The study provided no circRNA-specific mechanistic details or validation for this circRNA.	0.1768
35722400	Annals of translational medicine	2022	A ceRNA regulatory network in systemic lupus erythematosus and its molecular interplay with cancer.	hsa_circ_0003661				systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	unknown	RNA-seq	hsa_circ_0003661 was included in the SLE ceRNA network built from high-throughput sequencing and bioinformatics. No circRNA-specific targets or experimental validation were described.	0.1768
35722400	Annals of translational medicine	2022	A ceRNA regulatory network in systemic lupus erythematosus and its molecular interplay with cancer.	hsa_circ_0006515				systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	unknown	RNA-seq	hsa_circ_0006515 was included in the SLE ceRNA network assembled using RNA-seq and computational predictions. The article did not provide circRNA-specific validation or mechanistic details for hsa_circ_0006515.	0.1768
35722400	Annals of translational medicine	2022	A ceRNA regulatory network in systemic lupus erythematosus and its molecular interplay with cancer.	hsa_circ_0004604				systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	unknown	RNA-seq	hsa_circ_0004604 was included in the SLE ceRNA network produced by RNA-seq and downstream bioinformatics. No experimental validation or specific mechanism was provided for this circRNA.	0.1768
35722400	Annals of translational medicine	2022	A ceRNA regulatory network in systemic lupus erythematosus and its molecular interplay with cancer.	hsa_circ_0060158				systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	unknown	RNA-seq	hsa_circ_0060158 was included as part of the SLE circRNA_miRNA_mRNA ceRNA network built from RNA-seq and computational filtering. The article did not describe a specific miRNA/mRNA axis or experimental validation for this circRNA.	0.1768
35722400	Annals of translational medicine	2022	A ceRNA regulatory network in systemic lupus erythematosus and its molecular interplay with cancer.	hsa_circ_0056589				systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	unknown	RNA-seq	hsa_circ_0056589 was included among the circRNAs in the SLE ceRNA network constructed by bioinformatics. The study did not report direct experimental validation or a defined regulatory axis for this circRNA.	0.1768
35722400	Annals of translational medicine	2022	A ceRNA regulatory network in systemic lupus erythematosus and its molecular interplay with cancer.	hsa_circ_0073505				systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	unknown	RNA-seq	hsa_circ_0073505 was incorporated into the SLE ceRNA network from RNA-seq-based differential expression and computational prediction. The paper did not report target validation or functional assays for this circRNA.	0.1768
35722400	Annals of translational medicine	2022	A ceRNA regulatory network in systemic lupus erythematosus and its molecular interplay with cancer.	hsa_circ_0061938				systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	unknown	RNA-seq	hsa_circ_0061938 was one of the circRNAs in the SLE ceRNA regulatory network constructed via RNA-seq and bioinformatics. The study did not provide a validated interaction axis or functional experiments for this circRNA.	0.1768
35723373	Current issues in molecular biology	2022	Cyanidin-3-Glucoside Modulates hsa_circ_0001345/miRNA106b/ATG16L1 Axis Expression as a Potential Protective Mechanism against Hepatocellular Carcinoma.	hsa_circ_0001345	CircRNA0001345 / CircularRNA0001345			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	unknown	RT-qPCR	"This study proposes that hsa_circ_0001345 participates in a ceRNA axis with miRNA-106b and ATG16L1 in a DEN/2-AAF-induced liver precancerous lesion model. C3G treatment increased circRNA0001345 and ATG16L1 while reducing miRNA-106b, consistent with a protective, autophagy-related tumor-inhibitory mechanism via miRNA-106b sponging."	0.31
35725615	Cancer cell international	2022	Circular RNA EPB41 expression predicts unfavorable prognoses in NSCLC by regulating miR-486-3p/eIF5A axis-mediated stemness.	hsa_circ_0000042	circ-EPB41	hsa_circ_EPB41	EPB41	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circ-EPB41 is up-regulated in NSCLC and mainly localized in the cytoplasm. It promotes proliferation, invasion/metastasis and cancer stemness by sponging miR-486-3p, thereby increasing eIF5A expression; high circ-EPB41 is associated with worse overall survival."	0.8157
35726320	International journal of endocrinology	2022	Exosomal Circular RNA hsa_circ_0046060 of Umbilical Cord Mesenchymal Stromal Cell Ameliorates Glucose Metabolism and Insulin Resistance in Gestational Diabetes Mellitus via the miR-338-3p/G6PC2 Axis.	hsa_circ_0046060		hsa_circ_RPTOR	RPTOR	gestational diabetes mellitus / GDM	MONDO:0005406	gestational diabetes	up-regulated	RT-qPCR	"In GDM, exosomal hsa_circ_0046060 is upregulated and aggravates abnormal glucose metabolism/insulin resistance. It functions mainly via a ceRNA mechanism by sponging hsa-miR-338-3p, leading to increased G6PC2 and reduced IRS-1 activation; silencing hsa_circ_0046060 in exosomes reverses these effects in L-02 cells and a diet-induced GDM mouse model."	0.7759
35726320	International journal of endocrinology	2022	Exosomal Circular RNA hsa_circ_0046060 of Umbilical Cord Mesenchymal Stromal Cell Ameliorates Glucose Metabolism and Insulin Resistance in Gestational Diabetes Mellitus via the miR-338-3p/G6PC2 Axis.	mmu_circ_0002819		mmu_circ_Rptor	RPTOR	gestational diabetes mellitus / GDM	MONDO:0005406	gestational diabetes	up-regulated	RT-qPCR	"In a diet-induced GDM mouse model, exosomal mmu_circ_0002819 is upregulated and worsens glucose metabolism and insulin sensitivity. Knockdown of mmu_circ_0002819 in mUMSC-derived exosomes improves glucose/insulin tolerance and reverses increased hepatic G6PC2 and impaired IRS-1 activation observed with GDM-derived exosomes."	0.5925
35729156	International journal of oral science	2022	circ_0003204 regulates the osteogenic differentiation of human adipose-derived stem cells via miR-370-3p/HDAC4 axis.	hsa_circ_0003204	circ_0003204 / circRNA_0003204	hsa_circ_USP36	USP36	bone defects / cranial defects	MONDO:0002081	musculoskeletal system disorder	down-regulated	RT-qPCR	"circ_0003204 is downregulated during osteogenic differentiation of human adipose-derived stem cells and acts as a negative regulator of osteogenesis. Mechanistically, it sponges miR-370-3p to modulate HDAC4, and its silencing promotes bone formation/defect repair in a mouse cranial defect model."	0.7094
35730015	Disease markers	2022	Characterization of Circular RNA Expression Profiles in Colon Specimens of Patients with Slow Transit Constipation.	hsa_circ_0085173				Slow transit constipation / STC	MONDO:0002203	constipation disorder	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0085173 is significantly up-regulated in colon tissues from patients with slow transit constipation compared with controls, as supported by RNA-seq and qRT-PCR validation. It was included in the constructed (predicted) circRNA_miRNA_mRNA regulatory network for STC."	0.4032
35730015	Disease markers	2022	Characterization of Circular RNA Expression Profiles in Colon Specimens of Patients with Slow Transit Constipation.	hsa_circ_0000542				Slow transit constipation / STC	MONDO:0002203	constipation disorder	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000542 is significantly up-regulated in colon tissues from patients with slow transit constipation compared with controls, supported by RNA-seq and qRT-PCR. It was part of the study¡¯s predicted circRNA_miRNA_mRNA regulatory network analysis for STC."	0.4032
35730015	Disease markers	2022	Characterization of Circular RNA Expression Profiles in Colon Specimens of Patients with Slow Transit Constipation.	hsa_circ_0030694				Slow transit constipation / STC	MONDO:0002203	constipation disorder	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0030694 is significantly up-regulated in STC colon tissues versus controls and was validated by qRT-PCR. It was included in the predicted STC circRNA_miRNA_mRNA network constructed in this study.	0.4032
35730015	Disease markers	2022	Characterization of Circular RNA Expression Profiles in Colon Specimens of Patients with Slow Transit Constipation.	hsa_circ_0063716				Slow transit constipation / STC	MONDO:0002203	constipation disorder	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0063716 is significantly up-regulated in STC colon tissues compared with controls and was validated by qRT-PCR. The study included it when constructing predicted circRNA_miRNA_mRNA networks related to STC.	0.4032
35730015	Disease markers	2022	Characterization of Circular RNA Expression Profiles in Colon Specimens of Patients with Slow Transit Constipation.	hsa_circ_0016094				Slow transit constipation / STC	MONDO:0002203	constipation disorder	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0016094 is significantly down-regulated in STC colon tissues compared with controls, supported by RNA-seq and qRT-PCR. It was among the circRNAs used to construct predicted circRNA_miRNA_mRNA networks in STC."	0.4032
35730015	Disease markers	2022	Characterization of Circular RNA Expression Profiles in Colon Specimens of Patients with Slow Transit Constipation.	hsa_circ_0071410				Slow transit constipation / STC	MONDO:0002203	constipation disorder	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0071410 is significantly down-regulated in STC colon tissues and was validated by qRT-PCR. Bioinformatics predictions suggest a potential ceRNA relationship hsa_circ_0071410_hsa-miR-149-5p_SYT2 that may relate to neuromuscular junction/smooth muscle function in STC.	0.4032
35730015	Disease markers	2022	Characterization of Circular RNA Expression Profiles in Colon Specimens of Patients with Slow Transit Constipation.	hsa_circ_0063878				Slow transit constipation / STC	MONDO:0002203	constipation disorder	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0063878 is significantly down-regulated in STC colon tissues versus controls and was validated by qRT-PCR. It was included in the study¡¯s predicted circRNA_miRNA_mRNA regulatory network analysis for STC.	0.4032
35730015	Disease markers	2022	Characterization of Circular RNA Expression Profiles in Colon Specimens of Patients with Slow Transit Constipation.	hsa_circ_0004214				Slow transit constipation / STC	MONDO:0002203	constipation disorder	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0004214 is significantly down-regulated in STC colon tissues and was validated by qRT-PCR. Bioinformatics predictions suggest it may function via ceRNA mechanisms involving hsa-miR-526b-5p/TPM4 and hsa-miR-193a-5p/COL1A1, potentially linking to smooth muscle contraction or extracellular matrix regulation in STC."	0.4032
35730467	Bioengineered	2022	Circular RNA hsa_circ_0000437 may be used as a new indicator for the diagnosis and prognosis of hepatocellular carcinoma.	hsa_circ_0000437	circ_0000437			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"In HCC, hsa_circ_0000437 (circ_0000437) is significantly up-regulated in tumor tissue and patient serum. Higher serum levels are associated with poorer overall survival and show high diagnostic performance (AUC 0.9281), supporting its use as a diagnostic/prognostic biomarker."	0.5202
35730627	International journal of molecular medicine	2022	Silencing of circular RNA_ZYG11B exerts a neuroprotective effect against retinal neurodegeneration.	hsa_circ_0003739	circRNA-ZYG11B / circZYG11B	hsa_circ_ZYG11B	ZYG11B	retinal neurodegeneration	MONDO:0004580	retinal degeneration	up-regulated	RT-qPCR	"circZYG11B is up-regulated in ischemia/reperfusion-induced retinal neurodegeneration and in aqueous humor of glaucoma patients. Its knockdown protects retinal ganglion cells and alleviates retinal neurodegeneration, likely by acting as a miRNA sponge for miR-620 to modulate PTEN."	0.7296
35731336	Discover oncology	2022	Circ_0000705 facilitates proline metabolism of esophageal squamous cell carcinoma cells by targeting miR-621/PYCR1 axis.	hsa_circ_0000705	circ_0000705			esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"In ESCC, circ_0000705 is up-regulated and promotes malignant behaviors (proliferation, invasion, migration) and proline metabolism. It functions as a ceRNA that sponges miR-621, thereby increasing PYCR1 expression and supporting proline metabolism, and its high expression is associated with poor survival."	0.7713
35731831	Endocrinology	2022	Circ-CCNB1 Modulates Trophoblast Proliferation and Invasion in Spontaneous Abortion by Regulating miR-223/SIAH1 axis.		circ-CCNB1 / circRNA cyclin B1	hsa_circ_CCNB1	CCNB1	Spontaneous abortion / SA	MONDO:0006774	habitual spontaneous abortion	up-regulated	RT-qPCR	"In spontaneous abortion, circ-CCNB1 is up-regulated in villous tissues and suppresses trophoblast proliferation and invasion while promoting G0/G1 arrest. Mechanistically, circ-CCNB1 sponges miR-223 to increase SIAH1, which contributes to reduced CCNB1 nuclear translocation."	0.8288
35733786	Journal of bone oncology	2022	Circ_0051079 silencing inhibits the malignant phenotypes of osteosarcoma cells by the TRIM66/Wnt/beta-catenin pathway in a miR-625-5p-dependent manner.	hsa_circ_0051079	circ_0051079	hsa_circ_AKT2	AKT2	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ_0051079 is up-regulated in osteosarcoma tissues and cell lines and promotes malignant behaviors (proliferation, migration/invasion, and angiogenesis) while inhibiting apoptosis. Mechanistically, it sponges miR-625-5p to increase TRIM66 expression and activate Wnt/beta-catenin signaling, and its silencing suppresses xenograft tumor growth."	0.7597
35733856	Frontiers in medicine	2022	Circ_0004951 Promotes Pyroptosis of Renal Tubular Cells via the NLRP3 Inflammasome in Diabetic Kidney Disease.	hsa_circ_0004951	circ_0004951 / circTRPM7	hsa_circ_TRPM7	TRPM7	diabetic kidney disease / DKD	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR; RNA-seq	"circ_0004951 (circTRPM7; hsa_circ_0004951) is upregulated in DKD kidney tissues and in HK2 cells under high glucose. It promotes renal tubular cell pyroptosis and inflammation by sponging miR-93-5p, thereby increasing NLRP3 expression and activating the NLRP3 inflammasome."	0.7435
35734281	Frontiers in cardiovascular medicine	2022	The Particular Expression Profiles of Circular RNA in Peripheral Blood of Myocardial Infarction Patients by RNA Sequencing.	hsa_circ_0001414	circTMEM165 / circ-TMEM165	hsa_circ_TMEM165	TMEM165	myocardial infarction / MI	MONDO:0005068	myocardial infarction	up-regulated	RT-qPCR; RNA-seq	"circTMEM165 is up-regulated in peripheral blood of MI patients and was validated by RT-qPCR. The study predicts a ceRNA mechanism where circTMEM165 may sponge hsa-miR-548a-3p to influence GREM1-related processes, and it shows diagnostic potential via ROC analysis."	0.6957
35734281	Frontiers in cardiovascular medicine	2022	The Particular Expression Profiles of Circular RNA in Peripheral Blood of Myocardial Infarction Patients by RNA Sequencing.	hsa_circ_0030720	circUBAC2 / circ-UBAC2	hsa_circ_UBAC2	UBAC2	myocardial infarction / MI	MONDO:0005068	myocardial infarction	up-regulated	RT-qPCR; RNA-seq	circUBAC2 is up-regulated in MI peripheral blood and was validated by RT-qPCR. The study predicts circUBAC2 participates in circRNA_miRNA_mRNA regulatory networks and shows diagnostic potential via ROC analysis.	0.6957
35734281	Frontiers in cardiovascular medicine	2022	The Particular Expression Profiles of Circular RNA in Peripheral Blood of Myocardial Infarction Patients by RNA Sequencing.	hsa_circ_0000615	circZNF609 / circ-ZNF609	hsa_circ_ZNF609	ZNF609	myocardial infarction / MI	MONDO:0005068	myocardial infarction	up-regulated	RT-qPCR; RNA-seq	"circZNF609 is up-regulated in MI peripheral blood and validated by RT-qPCR. The study predicts a circZNF609_hsa-miR-221-5p_WDR7 ceRNA axis that may relate to LDL/lipid metabolism, and circZNF609 has diagnostic potential by ROC analysis."	0.6957
35734281	Frontiers in cardiovascular medicine	2022	The Particular Expression Profiles of Circular RNA in Peripheral Blood of Myocardial Infarction Patients by RNA Sequencing.	hsa_circ_0000826	circANKRD12 / circ-ANKRD12	hsa_circ_ANKRD12	ANKRD12	myocardial infarction / MI	MONDO:0005068	myocardial infarction	up-regulated	RT-qPCR; RNA-seq	"circANKRD12 is up-regulated in MI peripheral blood and validated by RT-qPCR. The study predicts ceRNA axes involving hsa-miR-876-5p/MYLK and hsa-miR-130b-5p/ACSM2A-RNF213, potentially linking it to contractile regulation and mitochondrial-related activities, and it has diagnostic potential by ROC analysis."	0.6957
35734281	Frontiers in cardiovascular medicine	2022	The Particular Expression Profiles of Circular RNA in Peripheral Blood of Myocardial Infarction Patients by RNA Sequencing.	hsa_circ_0000994	circSLC8A1 / circ-SLC8A1	hsa_circ_SLC8A1	SLC8A1	myocardial infarction / MI	MONDO:0005068	myocardial infarction	up-regulated	RT-qPCR; RNA-seq	"circSLC8A1 is up-regulated in MI peripheral blood and in an oxidative-stress AC16 injury model. Functionally, circSLC8A1 promotes mitochondrial fission and sensitizes cardiomyocytes to apoptosis under oxidative stress, with changes in Caspase3 and cyto c, and it shows strong diagnostic value by ROC analysis."	0.7921
35737129	Basic research in cardiology	2022	Reduction of A-to-I RNA editing in the failing human heart regulates formation of circular RNAs.	hsa_circ_0104801	circAKAP13	hsa_circ_AKAP13	AKAP13	heart failure / HF	MONDO:0005252	heart failure	up-regulated	RT-qPCR; RNA-seq	"circAKAP13 is up-regulated in failing human left ventricles. Reduced ADAR2-mediated A-to-I editing in intronic Alu elements promotes circAKAP13 circularization, while circAKAP13 overexpression in hiPSC-derived cardiomyocytes impairs sarcomere regularity, suggesting a pathological role in heart failure."	0.7403
35737129	Basic research in cardiology	2022	Reduction of A-to-I RNA editing in the failing human heart regulates formation of circular RNAs.		circPLCE1	hsa_circ_PLCE1	PLCE1	heart failure / HF	MONDO:0005252	heart failure	unknown	RT-qPCR	"circPLCE1 was selected among five circRNAs for further structural characterization in heart failure samples (circularity, localization), but the paper does not provide a circPLCE1-specific expression direction in HF or a dedicated functional mechanism."	0.5909
35737129	Basic research in cardiology	2022	Reduction of A-to-I RNA editing in the failing human heart regulates formation of circular RNAs.		circHDAC9	hsa_circ_HDAC9	HDAC9	heart failure / HF	MONDO:0005252	heart failure	unknown	RT-qPCR	"circHDAC9 was included among five circRNAs taken forward for experimental characterization of circularity/localization in the context of heart failure, but the paper does not report circHDAC9-specific regulation direction or functional mechanism."	0.5909
35737129	Basic research in cardiology	2022	Reduction of A-to-I RNA editing in the failing human heart regulates formation of circular RNAs.		circRELL1	hsa_circ_RELL1	RELL1	heart failure / HF	MONDO:0005252	heart failure	unknown	RT-qPCR	"circRELL1 was one of the five circRNAs selected for follow-up validation of circRNA properties in human heart samples; however, the study does not provide circRELL1-specific differential expression direction in HF or a detailed functional mechanism."	0.5909
35737129	Basic research in cardiology	2022	Reduction of A-to-I RNA editing in the failing human heart regulates formation of circular RNAs.		circSLC25A16	hsa_circ_SLC25A16	SLC25A16	heart failure / HF	MONDO:0005252	heart failure	unknown	RT-qPCR	"circSLC25A16 was selected for additional validation of circular features (RNase R resistance, back-splice confirmation, localization) in human heart-related experiments, but its HF-related expression direction and functional mechanism were not individually detailed in the provided text."	0.5909
35739524	Molecular cancer	2022	"circEXOC6B interacting with RRAGB, an mTORC1 activator, inhibits the progression of colorectal cancer by antagonizing the HIF1A-RRAGB-mTORC1 positive feedback loop."	hsa_circ_0009043	circEXOC6B	hsa_circ_EXOC6B	EXOC6B	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq; Microarray	"circEXOC6B (hsa_circ_0009043), derived from EXOC6B, is down-regulated in CRC tissues and its low expression correlates with worse outcomes. It suppresses CRC progression and enhances 5-FU sensitivity by binding RRAGB, disrupting RRAGB_RRAGC/D heterodimerization, inhibiting mTORC1 signaling and HIF1A, thereby antagonizing the HIF1A_RRAGB_mTORC1 positive feedback loop."	0.8869
35741665	Brain sciences	2022	CircXPO5 Plays a Neuroprotective Function in the Lateral Geniculate Nucleus of Glaucoma by Regulating GRIN2A.		circXPO5		XPO5	glaucoma	MONDO:0005041	glaucoma	down-regulated	RT-qPCR; RNA-seq	"In macaque glaucoma LGN, circXPO5 is down-regulated and is proposed to act as a ceRNA that sponges miR-330-5p, thereby influencing GRIN2A expression. The authors suggest circXPO5 reduction may be neuroprotective by affecting neuronal apoptosis during LGN degeneration."	0.4997
35743265	International journal of molecular sciences	2022	CircDCLRE1C Regulated Lipopolysaccharide-Induced Inflammatory Response and Apoptosis by Regulating miR-214b-3p/STAT3 Pathway in Macrophages.	gga_circ_0001647	circDCLRE1C / gga_circ_001674	gga_circ_DCLRE1C	DCLRE1C	coccidiosis 	MONDO:0005707	coccidiosis	up-regulated	RT-qPCR	"In chicken macrophages (HD11), circDCLRE1C is up-regulated under coccidia infection and LPS stimulation and promotes inflammatory cytokine production and apoptosis. Mechanistically, it sponges miR-214b-3p to de-repress STAT3, forming a circDCLRE1C/miR-214b-3p/STAT3 axis that aggravates inflammation."	0.8324
35744807	"Molecules (Basel, Switzerland)"	2022	The Expression and Bioinformatics Analysis of Circular RNAs in Endometritis Mouse Uterus Tissues.		circ-Chsy1 / Mus-circ-Chsy1	mmu_circ_Chsy1	Chsy1	endometritis	MONDO:0000918	endometritis	up-regulated	RT-qPCR; RNA-seq	"circ-Chsy1 is significantly up-regulated in uterine tissues from an E. coli-induced mouse endometritis model. The study suggests circRNAs may participate in endometritis-related inflammation via miRNA-associated regulation, but no circ-Chsy1-specific miRNA axis was experimentally validated."	0.4997
35744807	"Molecules (Basel, Switzerland)"	2022	The Expression and Bioinformatics Analysis of Circular RNAs in Endometritis Mouse Uterus Tissues.		circ-Gm49339 / Mus-circ-Gm49339	mmu_circ_Gm49339	Gm49339	endometritis	MONDO:0000918	endometritis	up-regulated	RT-qPCR; RNA-seq	"circ-Gm49339 is significantly up-regulated in uterine tissues of E. coli-induced mouse endometritis and is highlighted in a predicted circRNA_miRNA interaction network. Several miRNAs are predicted to target circ-Gm49339 (shared with circ-Vps54), but these interactions were not experimentally validated in this study."	0.4997
35744807	"Molecules (Basel, Switzerland)"	2022	The Expression and Bioinformatics Analysis of Circular RNAs in Endometritis Mouse Uterus Tissues.	mmu_circ_0001853		mmu_circ_Tgfbr2	Tgfbr2	endometritis	MONDO:0000918	endometritis	up-regulated	RT-qPCR; RNA-seq	mmu_circ_0001853 (host gene Tgfbr2) is significantly up-regulated in uterine tissues from an E. coli-induced mouse endometritis model and was validated by qRT-PCR consistent with RNA-seq. No specific downstream miRNA/mRNA targets or mechanisms were experimentally established for mmu_circ_0001853.	0.4997
35744807	"Molecules (Basel, Switzerland)"	2022	The Expression and Bioinformatics Analysis of Circular RNAs in Endometritis Mouse Uterus Tissues.		circ-Vps54	mmu_circ_Vps54	Vps54	endometritis	MONDO:0000918	endometritis	down-regulated	RT-qPCR; RNA-seq	"circ-Vps54 is significantly down-regulated in uterine tissues of an E. coli-induced mouse endometritis model and was validated by qRT-PCR. The study computationally predicts circ-Vps54 targets many miRNAs (including six shared with circ-Gm49339), suggesting a potential miRNA-sponge role that needs further experimental verification."	0.4997
35744807	"Molecules (Basel, Switzerland)"	2022	The Expression and Bioinformatics Analysis of Circular RNAs in Endometritis Mouse Uterus Tissues.	mmu_circ_0000668		mmu_circ_Mapk1	Mapk1	endometritis	MONDO:0000918	endometritis	down-regulated	RT-qPCR; RNA-seq	"mmu_circ_0000668 (host gene Mapk1) is significantly down-regulated in uterine tissues from an E. coli-induced mouse endometritis model, with RNA-seq results confirmed by qRT-PCR. The study does not provide a circRNA-specific mechanism or interaction axis for mmu_circ_0000668."	0.4997
35747400	Applied bionics and biomechanics	2022	circ-RANGAP1/MicroRNA-542-3p/Myosin Regulatory Light Chain Interacting Protein Axis Modulates the Osteosarcoma Cell Progression.		circ-RANGAP1 / circRNA- RANGAP1	hsa_circ_RANGAP1	RANGAP1	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ-RANGAP1 is up-regulated in osteosarcoma tissues/cells and its high expression is associated with poorer clinicopathological features and overall survival. Functionally, circ-RANGAP1 promotes OS cell proliferation, migration, and invasion and inhibits apoptosis by sponging miR-542-3p to regulate MYLIP."	0.7321
35747792	Frontiers in oncology	2022	"Serum and Serum Exosomal CircRNAs hsa_circ_0001492, hsa_circ_0001439, and hsa_circ_0000896 as Diagnostic Biomarkers for Lung Adenocarcinoma."	hsa_circ_0001492				lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"hsa_circ_0001492 is up-regulated in LUAD patient serum and serum-derived exosomes and decreases after tumor resection. It shows diagnostic potential (ROC AUC reported), and exosomal levels are associated with more aggressive clinicopathologic features and correlate with CEA and NSE."	0.459
35747792	Frontiers in oncology	2022	"Serum and Serum Exosomal CircRNAs hsa_circ_0001492, hsa_circ_0001439, and hsa_circ_0000896 as Diagnostic Biomarkers for Lung Adenocarcinoma."	hsa_circ_0001439				lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"hsa_circ_0001439 is elevated in LUAD patient serum and serum-derived exosomes and drops after tumor resection. It shows diagnostic potential (ROC AUC reported), with exosomal measurements performing better than serum measurements."	0.459
35747792	Frontiers in oncology	2022	"Serum and Serum Exosomal CircRNAs hsa_circ_0001492, hsa_circ_0001439, and hsa_circ_0000896 as Diagnostic Biomarkers for Lung Adenocarcinoma."	hsa_circ_0000896				lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"hsa_circ_0000896 is elevated in LUAD patient serum and serum-derived exosomes and decreases after tumor resection. It has diagnostic potential with relatively high AUC, especially in serum exosomes."	0.459
35754140	Journal of clinical laboratory analysis	2022	Circular RNA hsa_circ_0043688 serves as a competing endogenous RNA for microRNA-145-5p to promote the progression of Keloids via Fibroblast growth factor-2.	hsa_circ_0043688	circ_0043688	hsa_circ_FKBP10	FKBP10	keloid	MONDO:0005348	keloid	up-regulated	RT-qPCR	"hsa_circ_0043688 is up-regulated in keloid tissues and keloid fibroblasts and mainly localizes to the cytoplasm. It promotes keloid fibroblast proliferation, invasion/migration and ECM production while inhibiting apoptosis by acting as a ceRNA that sponges miR-145-5p to increase FGF2."	0.7635
35755416	Pathology oncology research : POR	2022	Plasma Exosomal hsa_circ_0015286 as a Potential Diagnostic and Prognostic Biomarker for Gastric Cancer.	hsa_circ_0015286				gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"Plasma exosomal hsa_circ_0015286 is significantly up-regulated in gastric cancer and correlates with tumor size, T stage and lymph node metastasis. It shows diagnostic value by ROC analysis and has prognostic relevance, where higher expression is associated with poorer overall survival; its level decreases after surgery, suggesting association with tumor burden."	0.5202
35755822	Frontiers in molecular biosciences	2022	Targeted Analysis of circRNA Expression in Patient Samples by Lexo-circSeq.		circSLC8A1 / circNCX1	hsa_circ_SLC8A1	SLC8A1	cardiomyopathy	MONDO:0004994	cardiomyopathy	dysregulated	RT-qPCR; RNA-seq	"Using Lexo-circSeq on human heart biopsies, the study reports a decreased circular-to-linear ratio for circSLC8A1 in DCM versus HTX controls. In hiPSC-derived cardiomyocytes, siRNA knockdown of circSLC8A1 or linSLC8A1 alters the CLR in the expected direction, supporting assay sensitivity and circ/lin balance changes."	0.4997
35755822	Frontiers in molecular biosciences	2022	Targeted Analysis of circRNA Expression in Patient Samples by Lexo-circSeq.		circRBM33	hsa_circ_RBM33	RBM33	cardiomyopathy	MONDO:0004994	cardiomyopathy	dysregulated	RNA-seq	"In human heart biopsy samples, circRBM33 shows an increased circular-to-linear ratio in both dilated and hypertrophic cardiomyopathy compared with HTX controls, attributed mainly to reduced linear RBM33 transcript levels. The study does not define a downstream mechanistic axis for circRBM33 in cardiomyopathy."	0.348
35756421	Computational and mathematical methods in medicine	2022	Circular RNA circ-ABCB10 Promotes Proliferation and Inhibits Apoptosis of Laryngeal Carcinoma by Inhibiting KLF6.	hsa_circ_0008717	circ-ABCB10	hsa_circ_ABCB10	ABCB10	laryngeal carcinoma	MONDO:0002358	laryngeal carcinoma	down-regulated	RT-qPCR	"circ-ABCB10 is aberrantly expressed in laryngeal carcinoma and functionally promotes proliferation, migration/invasion while inhibiting apoptosis in laryngeal cancer cells. Mechanistically, it exerts these effects by targeting and inhibiting the transcription factor KLF6, and KLF6 inhibition can reverse phenotypes caused by circ-ABCB10 interference."	0.6917
35756996	Frontiers in cell and developmental biology	2022	Mechanism of Liver Regeneration During ALPPS.	hsa_circ_0067724	circ-0067724			liver cancer	MONDO:0002691	liver cancer	up-regulated	RT-qPCR; RNA-seq	"circ-0067724 is increased after ALPPS and its knockdown suppresses hepatocyte proliferation, suggesting it promotes liver regeneration. The study predicts it may function as a miRNA sponge, but specific downstream targets were not experimentally validated."	0.4062
35756996	Frontiers in cell and developmental biology	2022	Mechanism of Liver Regeneration During ALPPS.	hsa_circ_0016213	circ-0016213			liver cancer	MONDO:0002691	liver cancer	up-regulated	RT-qPCR; RNA-seq	"circ-0016213 is increased after ALPPS and its knockdown suppresses hepatocyte proliferation, supporting a pro-regenerative role. It is predicted to interact with downstream miRNAs (miRNA sponge model), but the downstream effectors were not validated in this paper."	0.4062
35757392	Frontiers in endocrinology	2022	Identification of Serum Exosome-Derived circRNA-miRNA-TF-mRNA Regulatory Network in Postmenopausal Osteoporosis Using Bioinformatics Analysis and Validation in Peripheral Blood-Derived Mononuclear Cells.	hsa_circ_0023417				postmenopausal osteoporosis / PMOP	MONDO:0008159	postmenopausal osteoporosis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0023417 is up-regulated in PMOP and retained in the final validated circRNA-miRNA-TF-mRNA ceRNA network, suggesting it may act as a regulator in PMOP through ceRNA-related regulation involving miRNAs, TFs and downstream mRNAs."	0.4032
35757392	Frontiers in endocrinology	2022	Identification of Serum Exosome-Derived circRNA-miRNA-TF-mRNA Regulatory Network in Postmenopausal Osteoporosis Using Bioinformatics Analysis and Validation in Peripheral Blood-Derived Mononuclear Cells.	hsa_circ_0078309	hsa_circRNA_0078309	hsa_circ_ESR1	ESR1	postmenopausal osteoporosis / PMOP	MONDO:0008159	postmenopausal osteoporosis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0078309 (host gene ESR1) is up-regulated in PMOP and included in the final validated ceRNA network, and is suggested to potentially regulate bone metabolism in PMOP via circRNA-miRNA-TF-mRNA regulation."	0.4032
35757392	Frontiers in endocrinology	2022	Identification of Serum Exosome-Derived circRNA-miRNA-TF-mRNA Regulatory Network in Postmenopausal Osteoporosis Using Bioinformatics Analysis and Validation in Peripheral Blood-Derived Mononuclear Cells.	hsa_circ_0063533				postmenopausal osteoporosis / PMOP	MONDO:0008159	postmenopausal osteoporosis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0063533 is up-regulated in PMOP and included in the final validated circRNA-miRNA-TF-mRNA ceRNA network, indicating potential involvement in PMOP through ceRNA-associated regulation."	0.4032
35757392	Frontiers in endocrinology	2022	Identification of Serum Exosome-Derived circRNA-miRNA-TF-mRNA Regulatory Network in Postmenopausal Osteoporosis Using Bioinformatics Analysis and Validation in Peripheral Blood-Derived Mononuclear Cells.	hsa_circ_0036760				postmenopausal osteoporosis / PMOP	MONDO:0008159	postmenopausal osteoporosis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0036760 is up-regulated in PMOP and included in the final validated circRNA-miRNA-TF-mRNA ceRNA network, suggesting a potential regulatory role in PMOP via ceRNA-associated interactions."	0.4032
35758064	European heart journal	2022	A circular RNA derived from the insulin receptor locus protects against doxorubicin-induced cardiotoxicity.	hsa_circ_0000885	Circ-INSR / circRNA insulin receptor	hsa_circ_INSR	INSR	heart failure / HF	MONDO:0005252	heart failure	down-regulated	RT-qPCR; RNA-seq	"Circ-INSR is down-regulated in doxorubicin-induced cardiotoxicity/heart failure in rodents and patients. Gain- and loss-of-function studies show Circ-INSR protects cardiomyocytes by reducing apoptosis and preserving mitochondrial/metabolic function, largely via physical and functional interaction with SSBP1; Brca1 promotes Circ-INSR formation."	0.8592
35758064	European heart journal	2022	A circular RNA derived from the insulin receptor locus protects against doxorubicin-induced cardiotoxicity.	mmu_circ_0014773	Circ-INSR / circRNA insulin receptor	mmu_circ_INSR	INSR	heart failure / HF	MONDO:0005252	heart failure	down-regulated	RT-qPCR; RNA-seq	"Circ-INSR is down-regulated in doxorubicin-induced cardiotoxicity/heart failure in rodents and patients. Gain- and loss-of-function studies show Circ-INSR protects cardiomyocytes by reducing apoptosis and preserving mitochondrial/metabolic function, largely via physical and functional interaction with SSBP1; Brca1 promotes Circ-INSR formation."	0.8592
35758280	Bioengineered	2022	"Circular RNA_0078767 upregulates Kruppel-like factor 9 expression by targeting microRNA-889, thereby inhibiting the progression of osteosarcoma."	hsa_circ_0078767	circ_0078767 / Circular RNA_0078767			osteosarcoma / OS	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; Microarray	"circ_0078767 is down-regulated in osteosarcoma and acts as a tumor suppressor. It sponges miR-889 to upregulate KLF9, thereby inhibiting proliferation, migration, invasion and EMT while promoting apoptosis, and it is associated with better overall survival when highly expressed."	0.8635
35760899	Cancer gene therapy	2022	CircRNA circ_0006156 inhibits the metastasis of prostate cancer by blocking the ubiquitination of S100A9.	hsa_circ_0006156	circ_0006156	hsa_circ_FNDC3B	FNDC3B	prostate cancer / PCa	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; RNA-seq	"circ_0006156 is down-regulated in prostate cancer tissues and cell lines and suppresses migration/invasion and metastasis. It directly binds S100A9 and increases S100A9 protein stability by reducing S100A9 ubiquitination, thereby inhibiting malignant progression in vitro and in vivo."	0.8517
35766420	Genetics and molecular biology	2022	Systematic analyses of a novel circRNA-related miRNAs prognostic signature for Cervical Cancer.	hsa_circ_0001498				cervical cancer / CC	MONDO:0002974	cervical cancer	down-regulated	RNA-seq; Microarray	hsa_circ_0001498 is down-regulated in cervical cancer tissues versus paired paracancerous cervical tissues based on GEO datasets and was used (together with two other circRNAs) to derive a circRNA-related miRNA prognostic signature via predicted circRNA_miRNA interactions.	0.2465
35766420	Genetics and molecular biology	2022	Systematic analyses of a novel circRNA-related miRNAs prognostic signature for Cervical Cancer.	hsa_circ_0066147				cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RNA-seq; Microarray	hsa_circ_0066147 is up-regulated in cervical cancer tissues versus paired paracancerous cervical tissues based on GEO datasets and was used (together with two other circRNAs) to derive a circRNA-related miRNA prognostic signature via predicted circRNA_miRNA interactions.	0.2465
35766420	Genetics and molecular biology	2022	Systematic analyses of a novel circRNA-related miRNAs prognostic signature for Cervical Cancer.	hsa_circ_0006948				cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RNA-seq; Microarray	hsa_circ_0006948 is up-regulated in cervical cancer tissues versus paired paracancerous cervical tissues based on GEO datasets and was used (together with two other circRNAs) to derive a circRNA-related miRNA prognostic signature via predicted circRNA_miRNA interactions.	0.2465
35766445	Journal of clinical laboratory analysis	2022	Hsa_circ_0005100 regulates tumorigenicity of colorectal carcinoma via miR-145-5p/MACC1 axis.	hsa_circ_0005100	Circ_0005100 / circ_FMN2	hsa_circ_FMN2	FMN2	colorectal carcinoma / CRC	MONDO:0024331	colorectal carcinoma	up-regulated	RT-qPCR	"hsa_circ_0005100 is up-regulated in colorectal carcinoma and mainly localized in the cytoplasm. It promotes CRC cell proliferation, cell-cycle progression, migration and invasion while inhibiting apoptosis by sponging miR-145-5p to upregulate MACC1, and its knockdown suppresses xenograft tumor growth."	0.7701
35767605	Science advances	2022	Suppression of osteoclast multinucleation via a posttranscriptional regulation-based spatiotemporally selective delivery system.	mmu_circ_0001757	circBBS9	mmu_circ_BBS9	BBS9	Osteoporosis / OP	MONDO:0005298	osteoporosis	up-regulated	RT-qPCR; RNA-seq	"In mouse osteoclast lineage cells, circBBS9 (mmu_circ_0001757; host gene BBS9) is up-regulated during RANKL-induced preosteoclast stages and promotes osteoclast multinucleation. Mechanistically, it acts as a sponge for miR-423-3p to increase Traf6 signaling/output, and targeted knockdown (including in OVX osteoporosis mice) reduces multinucleated osteoclast formation and bone resorption."	0.7843
35767605	Science advances	2022	Suppression of osteoclast multinucleation via a posttranscriptional regulation-based spatiotemporally selective delivery system.	hsa_circ_0134188	hsa_circBBS9	hsa_circ_BBS9	BBS9	Osteoporosis / OP	MONDO:0005298	osteoporosis	up-regulated	RT-qPCR	"The human circRNA hsa_circ_0134188 (hsa_circBBS9) is elevated in cancellous bone from osteoporosis patients and increased during PBMC-derived osteoclast formation. Knockdown in human osteoclasts reduces osteoclast-related gene expression, supporting translational relevance to osteoporosis."	0.4128
35768408	Cell death discovery	2022	CircRNA-3302 promotes endothelial-to-mesenchymal transition via sponging miR-135b-5p to enhance KIT expression in Kawasaki disease.		circRNA-3302 / circ3302			Kawasaki disease / KD	MONDO:0012727	Kawasaki disease	up-regulated	RT-qPCR; RNA-seq	"circ3302 is up-regulated in KD serum-stimulated endothelial cells and in a CAWS-induced KD mouse model. It promotes KD-associated EndMT mainly by sponging miR-135b-5p in the cytoplasm, which relieves repression of KIT translation and increases KIT protein expression."	0.6887
35768865	Molecular cancer	2022	circFBXO7/miR-96-5p/MTSS1 axis is an important regulator in the Wnt signaling pathway in ovarian cancer.		circFBXO7	hsa_circ_FBXO7	FBXO7	ovarian cancer / OC	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR; ISH; RNA-seq	"circFBXO7 is down-regulated in ovarian cancer and acts as a tumor suppressor. It sponges miR-96-5p to upregulate MTSS1, thereby inactivating Wnt/beta-catenin signaling and inhibiting proliferation, EMT-associated migration/invasion, tumor growth and metastasis. Low circFBXO7 expression correlates with worse patient survival, suggesting prognostic/diagnostic value."	0.8719
35769514	Journal of immunology research	2022	circACTG1 Promotes Hepatocellular Carcinoma Progression by Regulating miR-940/RIF1 Axis and Activating AKT/mTOR Pathway.	hsa_circ_0046144	circACTG1 	hsa_circ_ACTG1	ACTG1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circACTG1 (hsa_circ_0046144) is up-regulated in HCC tissues and cell lines and promotes proliferation, migration, invasion, and xenograft growth. Mechanistically, it sponges miR-940 to upregulate RIF1 and activate AKT/mTOR signaling, and high circACTG1 expression is associated with poorer patient prognosis and has diagnostic value by ROC analysis."	0.7736
35770986	Microbiology spectrum	2022	Circ-Udg Derived from Cyprinid Herpesvirus 2 Promotes Viral Replication.		circ-udg		udg	gibel carp bleeding disease	MONDO:0005108	viral infectious disease	up-regulated	RT-qPCR; Northern Blot; ISH; RNA-seq	"circ-udg is a CyHV-2-derived circRNA up-regulated during infection that promotes viral proliferation/replication in EPC cells. It functions in part by encoding the truncated protein circ-udg-P147 via an IRES-dependent mechanism, which elevates UDG protein levels and enhances viral gene (e.g., ORF72) expression."	0.769
35773744	Molecular cancer	2022	CircEZH2/miR-133b/IGF2BP2 aggravates colorectal cancer progression via enhancing the stability of m6A-modified CREB1 mRNA.	hsa_circ_0006357	circEZH2	hsa_circ_EZH2	EZH2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"circEZH2 (hsa_circ_0006357) is up-regulated in colorectal cancer and predicts poor overall survival. It promotes CRC proliferation, migration and metastasis by sponging miR-133b to increase IGF2BP2, and by binding IGF2BP2 to prevent its ubiquitination-dependent degradation, thereby enhancing the stability of m6A-modified CREB1 mRNA."	0.8839
35778952	Journal of clinical laboratory analysis	2022	hsa_circ_0115355 promotes pancreatic beta-cell function in patients with type 2 diabetes through the miR-145/SIRT1 axis.	hsa_circ_0115355	circCSE1L	hsa_circ_CSE1L	CSE1L	type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RT-qPCR; Microarray	"hsa_circ_0115355 (also referred to as circCSE1L) is down-regulated in T2DM patient serum and in high-glucose_treated INS-1 cells. Functionally, it protects beta-cell models from glucolipotoxicity by promoting proliferation and insulin secretion and inhibiting apoptosis, mainly via a ceRNA mechanism in which it sponges miR-145 to upregulate SIRT1."	0.7884
35779530	Aging	2022	circEPSTI1 promotes tumor progression and cisplatin resistance via upregulating MSH2 in cervical cancer.		circEPSTI1	hsa_circ_EPSTI1	EPSTI1	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	circEPSTI1 is up-regulated in cervical cancer tissues and cell lines. It promotes cervical cancer cell proliferation and migration and increases cisplatin resistance by acting as a ceRNA that sponges miR-370-3p to upregulate MSH2.	0.8111
35780119	Molecular cancer	2022	Circular RNA EIF4G3 suppresses gastric cancer progression through inhibition of beta-catenin by promoting delta-catenin ubiquitin degradation and upregulating SIK1.	hsa_circ_0007991	circEIF4G3	hsa_circ_EIF4G3	EIF4G3	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"circEIF4G3 (hsa_circ_0007991), derived from EIF4G3, is downregulated in gastric cancer tissues and serum and is associated with poor outcomes. Functionally, it suppresses GC proliferation and metastasis and promotes apoptosis. Mechanistically, it inhibits Wnt/beta-catenin signaling by promoting TRIM25-mediated ubiquitination/degradation of delta-catenin and by sponging miR-4449 to upregulate SIK1."	0.8989
35782101	PeerJ	2022	The potential of CircRNA1002 as a biomarker in hepatitis B virus-related hepatocellular carcinoma.		circRNA1002	hsa_circ_MED13L	MED13L	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"circRNA1002 is consistently down-regulated in HBV-related HCC in both serum/whole blood and tumor tissue versus controls. The study proposes circRNA1002 as a stable serum biomarker for HCC and predicts a circRNA-miRNA-mRNA network involving multiple miRNAs and downstream mRNAs, with enrichment in hormone-related and cell-cell interaction processes."	0.5135
35782101	PeerJ	2022	The potential of CircRNA1002 as a biomarker in hepatitis B virus-related hepatocellular carcinoma.		circRNA7941	hsa_circ_MBOAT2	MBOAT2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	circRNA7941 is experimentally validated by RT-qPCR to be down-regulated in HBV-related HCC tumor tissue compared with matched adjacent tissue. No specific downstream mechanism or clinical utility is established for circRNA7941 in this study.	0.429
35782101	PeerJ	2022	The potential of CircRNA1002 as a biomarker in hepatitis B virus-related hepatocellular carcinoma.		circRNA 39338	hsa_circ_AKT3	AKT3	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"circRNA39338 is validated as down-regulated in whole blood from HBV-related HCC patients compared with HBV asymptomatic carriers, consistent with RNA-seq. The study does not establish a specific mechanism or clinical utility for circRNA39338."	0.4773
35782101	PeerJ	2022	The potential of CircRNA1002 as a biomarker in hepatitis B virus-related hepatocellular carcinoma.		circRNA44142	hsa_circ_PPP2R5C	PPP2R5C	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	circRNA44142 is validated by RT-qPCR to be down-regulated in HBV-related HCC tumor tissue compared with matched adjacent tissue. The study does not provide a specific downstream mechanism or clinical value for circRNA44142.	0.429
35782902	Oncology letters	2022	Identification of circular RNA_0000919 as a potential diagnostic and prognostic biomarker of tongue squamous cell carcinoma using circular RNA microarray and reverse transcription-quantitative PCR analyses.	hsa_circ_0020048	circ_0020048	hsa_circ_TCF7L2	TCF7L2	tongue squamous cell carcinoma / TSCC	MONDO:0000500	tongue squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	circ_0020048 is up-regulated in TSCC tumor tissues versus adjacent tissues and is positively associated with higher T stage and TNM stage.	0.5135
35782902	Oncology letters	2022	Identification of circular RNA_0000919 as a potential diagnostic and prognostic biomarker of tongue squamous cell carcinoma using circular RNA microarray and reverse transcription-quantitative PCR analyses.	hsa_circ_0000919	circular RNA_0000919 / circ_0000919	hsa_circ_ATP13A1	ATP13A1	tongue squamous cell carcinoma / TSCC	MONDO:0000500	tongue squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0000919 is up-regulated in TSCC and its higher tumor expression predicts worse overall survival. It is associated with more advanced tumor stage and is hypothesized to act as a miRNA sponge (e.g., miR-1587, miR-1226-3p)."	0.5963
35782902	Oncology letters	2022	Identification of circular RNA_0000919 as a potential diagnostic and prognostic biomarker of tongue squamous cell carcinoma using circular RNA microarray and reverse transcription-quantitative PCR analyses.	hsa_circ_0004525	circ_0004525	hsa_circ_RBCK1	RBCK1	tongue squamous cell carcinoma / TSCC	MONDO:0000500	tongue squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0004525 is up-regulated in TSCC tumor tissues compared with adjacent tissues, but was not associated with tumor features or overall survival in this cohort."	0.5135
35782902	Oncology letters	2022	Identification of circular RNA_0000919 as a potential diagnostic and prognostic biomarker of tongue squamous cell carcinoma using circular RNA microarray and reverse transcription-quantitative PCR analyses.	hsa_circ_0002113	circ_0002113	hsa_circ_IFNGR2	IFNGR2	tongue squamous cell carcinoma / TSCC	MONDO:0000500	tongue squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	circ_0002113 is up-regulated in TSCC tumor tissues compared with adjacent tissues; no significant associations with tumor features or overall survival were reported.	0.5135
35782902	Oncology letters	2022	Identification of circular RNA_0000919 as a potential diagnostic and prognostic biomarker of tongue squamous cell carcinoma using circular RNA microarray and reverse transcription-quantitative PCR analyses.	hsa_circ_0004029	circ_0004029	hsa_circ_UXS1	UXS1	tongue squamous cell carcinoma / TSCC	MONDO:0000500	tongue squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	circ_0004029 is down-regulated in TSCC tumor tissues compared with adjacent tissues; no significant associations with clinical features or overall survival were reported.	0.5135
35782902	Oncology letters	2022	Identification of circular RNA_0000919 as a potential diagnostic and prognostic biomarker of tongue squamous cell carcinoma using circular RNA microarray and reverse transcription-quantitative PCR analyses.	hsa_circ_0004503	circ_0004503	hsa_circ_UBE2D2	UBE2D2	tongue squamous cell carcinoma / TSCC	MONDO:0000500	tongue squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	circ_0004503 is down-regulated in TSCC tumor tissues and its lower levels are associated with higher pathological grade; no association with overall survival was reported.	0.5135
35782902	Oncology letters	2022	Identification of circular RNA_0000919 as a potential diagnostic and prognostic biomarker of tongue squamous cell carcinoma using circular RNA microarray and reverse transcription-quantitative PCR analyses.	hsa_circ_0008752	circ_0008752	hsa_circ_CNOT7	CNOT7	tongue squamous cell carcinoma / TSCC	MONDO:0000500	tongue squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	circ_0008752 is down-regulated in TSCC tumor tissues and lower expression correlates with higher pathological grade and lymph node stage; no overall survival association was found.	0.5135
35782902	Oncology letters	2022	Identification of circular RNA_0000919 as a potential diagnostic and prognostic biomarker of tongue squamous cell carcinoma using circular RNA microarray and reverse transcription-quantitative PCR analyses.	hsa_circ_0002300	circ_0002300	hsa_circ_CANX	CANX	tongue squamous cell carcinoma / TSCC	MONDO:0000500	tongue squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	"circ_0002300 is down-regulated in TSCC tumor tissues and lower expression is associated with more advanced clinicopathological features (grade, N stage, TNM stage); no overall survival association was found."	0.5135
35782902	Oncology letters	2022	Identification of circular RNA_0000919 as a potential diagnostic and prognostic biomarker of tongue squamous cell carcinoma using circular RNA microarray and reverse transcription-quantitative PCR analyses.	hsa_circ_0001811	circ_0001811	hsa_circ_STAU2	STAU2	tongue squamous cell carcinoma / TSCC	MONDO:0000500	tongue squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	circ_0001811 is down-regulated in TSCC tumor tissues compared with adjacent tissues; it was not associated with clinicopathological features or overall survival in this study.	0.5135
35783013	Disease markers	2022	"circIFT80 Functions as a ceRNA for miR-142, miR-568, and miR-634 and Promotes the Progression of Colorectal Cancer by Targeting beta-Catenin."	hsa_circ_0067835	circIFT80 / circ0067835 	hsa_circ_IFT80	IFT80	Colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circIFT80 is up-regulated in colorectal cancer tissues and cells and functions as an oncogenic circRNA. It sponges miR-142/miR-568/miR-634 to increase CTNNB1 (beta-catenin) expression, activating Wnt/beta-catenin signaling and promoting proliferation, cell-cycle progression, migration, and tumor growth while inhibiting apoptosis."	0.7741
35783154	Journal of oncology	2022	circCCT3 Enhances Invasion and Epithelial-Mesenchymal Transition (EMT) of Non-Small-Cell Lung Cancer (NSCLC) via the miR-107/Wnt/FGF7 Axis.		circCCT3	hsa_circ_CCT3	CCT3	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	unknown	RT-qPCR	"In NSCLC cell lines, circCCT3 promotes invasion and EMT. Mechanistically, circCCT3 functions as a ceRNA for miR-107, thereby regulating Wnt3a/Wnt signaling and downstream FGF7 to drive metastatic phenotypes."	0.3963
35784154	Journal of dental sciences	2022	"Circ_0138959/miR-495-3p/TRAF6 axis regulates proliferation, wound healing and osteoblastic differentiation of periodontal ligament cells in periodontitis."	hsa_circ_0138959	circ_0138959	hsa_circ_GDA	GDA	periodontitis	MONDO:0005076	periodontitis	up-regulated	RT-qPCR	"Circ_0138959 is up-regulated in chronic periodontitis periodontal ligament tissues and in LPS-treated PDLCs, where it aggravates LPS-induced cell injury. Mechanistically, it sponges miR-495-3p to de-repress TRAF6, leading to reduced proliferation/wound healing/osteogenic differentiation and increased apoptosis and inflammation."	0.7412
35784473	Frontiers in cell and developmental biology	2022	Huaier Induces Immunogenic Cell Death Via CircCLASP1/PKR/eIF2alpha Signaling Pathway in Triple Negative Breast Cancer.	hsa_circ_0002374	circCLASP1	hsa_circ_CLASP1	CLASP1	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; RNA-seq	"circCLASP1 (hsa_circ_0002374), derived from CLASP1, is up-regulated after Huaier treatment in TNBC cells. It binds and stabilizes PKR in the cytoplasm, enhancing PKR/eIF2alpha (and ATF4) signaling to promote ER stress-associated immunogenic cell death and suppress TNBC cell proliferation."	0.7962
35784724	Frontiers in pharmacology	2022	Construction of a Novel circRNA/miRNA/mRNA Regulatory Network to Explore the Potential Pathogenesis of Wilson's Disease.	mmu_circ_0001333	circRNA.2110 (mmu_circ_0001333)			Wilson¡¯s disease / WD	MONDO:0010200	Wilson disease	up-regulated	RT-qPCR; RNA-seq	"mmu_circ_0001333 is up-regulated in WD mouse kidneys and is part of a circRNA_miRNA_mRNA ceRNA network. It may contribute to WD-related kidney injury by sponging miRNAs (e.g., miR-107-3p) and thereby regulating targets such as Smad9."	0.4997
35784724	Frontiers in pharmacology	2022	Construction of a Novel circRNA/miRNA/mRNA Regulatory Network to Explore the Potential Pathogenesis of Wilson's Disease.	mmu_circ_0000355				Wilson¡¯s disease / WD	MONDO:0010200	Wilson disease	down-regulated	RT-qPCR; RNA-seq	"mmu_circ_0000355 is down-regulated in WD mouse kidneys and was qRT-PCR validated. It may participate in WD-related kidney injury via a ceRNA mechanism by sponging miR-92b-5p/miR-107-3p/miR-187-3p and modulating downstream mRNAs including Smad9, Mapk10 and Aldh3a2."	0.4997
35785045	Regenerative therapy	2022	Downregulation of hsa_circ_0000885 suppressed osteosarcoma metastasis and progression via regulating E2F3 expression and sponging miR-16-5p.	hsa_circ_0000885	circ_0000885 / circ0000885			osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"hsa_circ_0000885 is up-regulated in osteosarcoma cell lines and acts as an oncogenic circRNA. Its knockdown suppresses proliferation, invasion/migration, tumor growth and lung metastasis, and reduces stemness markers. Mechanistically, hsa_circ_0000885 sponges miR-16-5p to enhance E2F3, and the miR-16-5p/E2F3 axis mediates these phenotypes."	0.5634
35786385	BMC oral health	2022	Analysis of circRNAs profile in TNF-alpha treated DPSC.	hsa_circ_0001978				pulpitis	MONDO:0006937	pulpitis	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0001978 is up-regulated in pulpitis dental pulp and in TNF-alpha-treated DPSCs. The study predicts it may act in a circRNA_miRNA_mRNA network and be involved in pulpitis-associated inflammation via MAPK and Wnt signaling pathways.	0.585
35786385	BMC oral health	2022	Analysis of circRNAs profile in TNF-alpha treated DPSC.	hsa_circ_0003910				pulpitis	MONDO:0006937	pulpitis	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0003910 is up-regulated in TNF-alpha-treated DPSCs and is among circRNAs proposed to be linked to inflammation-related pathways in this model.	0.437
35786385	BMC oral health	2022	Analysis of circRNAs profile in TNF-alpha treated DPSC.	hsa_circ_0004314				pulpitis	MONDO:0006937	pulpitis	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0004314 is up-regulated in TNF-alpha-treated DPSCs and is among circRNAs proposed to be linked to inflammation-related pathways in this model.	0.437
35786385	BMC oral health	2022	Analysis of circRNAs profile in TNF-alpha treated DPSC.	hsa_circ_0004417				pulpitis	MONDO:0006937	pulpitis	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0004417 is up-regulated in pulpitis dental pulp and in TNF-alpha-treated DPSCs. The study predicts it may function through a circRNA_miRNA_mRNA network and be involved in pulpitis inflammation via MAPK and Wnt signaling pathways.	0.585
35786385	BMC oral health	2022	Analysis of circRNAs profile in TNF-alpha treated DPSC.	hsa_circ_0035915				pulpitis	MONDO:0006937	pulpitis	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0035915 is down-regulated in TNF-alpha-treated DPSCs and is among circRNAs proposed to be linked to inflammation-related pathways in this model.	0.437
35790503	Thoracic cancer	2022	A novel circ_0000654/miR-375/E2F3 ceRNA network in esophageal squamous cell carcinoma.	hsa_circ_0000654	circ_0000654	hsa_circ_CHD2	CHD2	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"circ_0000654 is up-regulated in ESCC tissues, serum, and cell lines, and functions as an oncogenic circRNA. It mainly localizes to the cytoplasm and acts as a ceRNA by sponging miR-375 to increase E2F3, thereby promoting proliferation and glycolysis while inhibiting apoptosis, and enhancing xenograft tumor growth."	0.7944
35790551	European journal of pediatrics	2022	"CircRNA, lncRNA, and mRNA profiles of umbilical cord blood exosomes from preterm newborns showing bronchopulmonary dysplasia."	hsa_circ_0086913		hsa_circ_TLN1	TLN1	Bronchopulmonary dysplasia / BPD	MONDO:0019091	bronchopulmonary dysplasia	up-regulated	RT-qPCR; Microarray	Exosomal hsa_circ_0086913 was upregulated in umbilical cord blood exosomes from preterm infants with BPD (validated by qRT-PCR). Bioinformatic ceRNA prediction suggested a potential hsa_circ_0086913/hsa-miR-103a-3p/TM4SF1 axis that may contribute to BPD development.	0.4032
35790551	European journal of pediatrics	2022	"CircRNA, lncRNA, and mRNA profiles of umbilical cord blood exosomes from preterm newborns showing bronchopulmonary dysplasia."	hsa_circ_0007372		hsa_circ_IFT46	IFT46	Bronchopulmonary dysplasia / BPD	MONDO:0019091	bronchopulmonary dysplasia	down-regulated	RT-qPCR; Microarray	"hsa_circ_0007372 was downregulated in umbilical cord blood-derived exosomes from preterm infants with BPD compared with NBPD, and this change was validated by qRT-PCR. No specific downstream mechanism was reported for this circRNA in the study."	0.3588
35790551	European journal of pediatrics	2022	"CircRNA, lncRNA, and mRNA profiles of umbilical cord blood exosomes from preterm newborns showing bronchopulmonary dysplasia."	hsa_circ_0065188		hsa_circ_PTPN23	PTPN23	Bronchopulmonary dysplasia / BPD	MONDO:0019091	bronchopulmonary dysplasia	down-regulated	RT-qPCR; Microarray	"hsa_circ_0065188 was downregulated in umbilical cord blood-derived exosomes from preterm infants with BPD compared with NBPD, and this change was validated by qRT-PCR. The study also reported decreased expression of hsa_circ_0065188 in LPS-induced HUVECs, but did not define a specific downstream regulatory axis for this circRNA."	0.3588
35790551	European journal of pediatrics	2022	"CircRNA, lncRNA, and mRNA profiles of umbilical cord blood exosomes from preterm newborns showing bronchopulmonary dysplasia."	hsa_circ_0049170		hsa_circ_OLFM2	OLFM2	Bronchopulmonary dysplasia / BPD	MONDO:0019091	bronchopulmonary dysplasia	unknown	RT-qPCR	"In an in vitro LPS-induced injury model using BEAS-2B cells, hsa_circ_0049170 expression was increased by RT-qPCR. The study did not report a downstream mechanism or functional effect specific to hsa_circ_0049170."	0.1155
35790551	European journal of pediatrics	2022	"CircRNA, lncRNA, and mRNA profiles of umbilical cord blood exosomes from preterm newborns showing bronchopulmonary dysplasia."	hsa_circ_0087059		hsa_circ_GRHPR	GRHPR	Bronchopulmonary dysplasia / BPD	MONDO:0019091	bronchopulmonary dysplasia	unknown	RT-qPCR	"In an in vitro LPS-induced injury model using BEAS-2B cells, hsa_circ_0087059 expression was increased by RT-qPCR. The study did not report a downstream mechanism or functional effect specific to hsa_circ_0087059."	0.1155
35791074	Journal of microbiology and biotechnology	2022	CircCOL1A2 Sponges MiR-1286 to Promote Cell Invasion and Migration of Gastric Cancer by Elevating Expression of USP10 to Downregulate RFC2 Ubiquitination Level.		circRNA_081069 / circCOL1A2	hsa_circ_COL1A2	COL1A2	Gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circCOL1A2 is up-regulated in gastric cancer cells and promotes migration and invasion. Mechanistically, it mainly localizes to the cytoplasm and acts as a ceRNA to sponge miR-1286, thereby increasing USP10 expression and reducing RFC2 ubiquitination to stabilize RFC2."	0.8024
35791460	Cell proliferation	2022	CircNFIX regulates chondrogenesis and cartilage homeostasis by targeting the miR758-3p/KDM6A axis.		hsa_circ_005660 / circNFIX	hsa_circ_NFIX	NFIX	Osteoarthritis / OA	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR; ISH; Microarray	"circNFIX is decreased in OA cartilage and supports cartilage homeostasis by promoting chondrogenesis and reducing ECM catabolism. It mainly functions as a cytoplasmic ceRNA, sponging miR-758-3p to relieve repression of KDM6A, which affects SOX9 methylation and chondrocyte phenotype. Intra-articular overexpression of circNFIX alleviates OA progression in the DMM mouse model."	0.8398
35791460	Cell proliferation	2022	CircNFIX regulates chondrogenesis and cartilage homeostasis by targeting the miR758-3p/KDM6A axis.	mmu_circ_0001704		mmu_circ_NFIX	NFIX	Osteoarthritis / OA	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR; ISH; Microarray	"circNFIX is decreased in OA cartilage and supports cartilage homeostasis by promoting chondrogenesis and reducing ECM catabolism. It mainly functions as a cytoplasmic ceRNA, sponging miR-758-3p to relieve repression of KDM6A, which affects SOX9 methylation and chondrocyte phenotype. Intra-articular overexpression of circNFIX alleviates OA progression in the DMM mouse model."	0.8398
35791807	The Kaohsiung journal of medical sciences	2022	Overexpression of circ PTK2 suppresses the progression of nonalcoholic fatty liver disease via the miR-200c/SIK2/PI3K/Akt axis.	hsa_circ_0007521	Circ PTK2 / circRNA PTK2	hsa_circ_PTK2	PTK2	nonalcoholic fatty liver disease / NAFLD	MONDO:0013209	metabolic dysfunction-associated steatotic liver disease	down-regulated	RT-qPCR	"circ PTK2 is down-regulated in NAFLD models. Its overexpression reduces hepatocyte lipid accumulation by sponging miR-200c, restoring SIK2 expression and inhibiting PI3K/Akt signaling, thereby alleviating NAFLD progression in vitro and in HFD-induced mice."	0.6811
35792043	Journal of clinical laboratory analysis	2022	Prognostic significance of hsa_circ_0048122 to predict liver metastasis in early-stage colorectal cancer.	hsa_circ_0048122				colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"hsa_circ_0048122 is up-regulated in CRC tumor tissues and further elevated in liver metastases compared with primary CRC. High expression is associated with higher liver metastasis risk and predicts worse OS in CRCLM and worse LMFS in early-stage CRC, supporting its use as a biomarker for metachronous liver metastasis prediction."	0.5339
35795047	Frontiers in oncology	2022	CircASPH Promotes Hepatocellular Carcinoma Progression Through Methylation and Expression of HAO2.		circASPH	hsa_circ_ASPH	ASPH	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circASPH is up-regulated in HCC tissues/cell lines and promotes proliferation, migration, invasion and xenograft tumor growth. It acts as a cytoplasmic sponge for miR-370-3p, relieving repression of DNMT3b, increasing 5mC, enhancing HAO2 promoter methylation, and reducing HAO2 expression, thereby driving HCC progression and associating with worse overall survival."	0.8308
35798876	Oncogene	2022	CircME1 promotes aerobic glycolysis and sunitinib resistance of clear cell renal cell carcinoma through cis-regulation of ME1.		circME1	hsa_circ_ME1	ME1	clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR; RNA-seq	"circME1 is up-regulated in ccRCC (including sunitinib-resistant cells) and promotes proliferation, migration/invasion, metastasis, aerobic glycolysis, and sunitinib resistance. Mechanistically, it binds U1 snRNP and cis-activates its host gene ME1 transcription at the ME1 promoter, elevating ME1 and downstream glycolytic enzymes; ME1 inhibition counteracts circME1-driven phenotypes."	0.8787
35799265	Journal of orthopaedic surgery and research	2022	"Circ-FOXM1 promotes the proliferation, migration and EMT process of osteosarcoma cells through FOXM1-mediated Wnt pathway activation."	hsa_circ_0025033	circ-FOXM1	hsa_circ_FOXM1	FOXM1	Osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ-FOXM1 is up-regulated in osteosarcoma cell lines and promotes proliferation, migration, EMT and tumor growth while suppressing apoptosis. Mechanistically, it functions as a ceRNA to sponge miR-320a/miR-320b, elevating FOXM1 and activating the Wnt/beta-catenin pathway."	0.7797
35800365	"Cancer drug resistance (Alhambra, Calif.)"	2022	Circular RNA drives resistance to anti-PD-1 immunotherapy by regulating the miR-30a-5p/SOX4 axis in non-small cell lung cancer.	hsa_circ_0020714		hsa_circ_CD151	CD151	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0020714 is upregulated in NSCLC tissues and is associated with poor prognosis and resistance to anti-PD-1 therapy. It promotes immune evasion by sponging miR-30a-5p, thereby increasing SOX4 expression, and enhances anti-PD-1 resistance in vivo."	0.7909
35805051	Cancers	2022	Triple-Negative Breast Cancer circRNAome Reveals Hsa_circ_0072309 as a Potential Risk Biomarker.	hsa_circ_0072309	circ_0072309	hsa_circ_LIFR	LIFR	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0072309 is consistently down-regulated in TNBC across RNA-seq and RT-qPCR validation cohorts and can discriminate TNBC from non-cancer breast samples (AUC ~0.78_0.81). Its putative role is linked to circRNA_RBP interactions, with predicted RBPs enriched in cancer-related gene regulation pathways."	0.5047
35805051	Cancers	2022	Triple-Negative Breast Cancer circRNAome Reveals Hsa_circ_0072309 as a Potential Risk Biomarker.	hsa_circ_0004365	circ_0004365	hsa_circ_SEMA3C	SEMA3C	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	down-regulated	RNA-seq	"hsa_circ_0004365 is down-regulated in TNBC in RNA-seq and was included in circRNA_RBP interaction prediction analyses, suggesting a potential role in gene regulation via RBPs."	0.1768
35805051	Cancers	2022	Triple-Negative Breast Cancer circRNAome Reveals Hsa_circ_0072309 as a Potential Risk Biomarker.	hsa_circ_0006677	circ_0006677	hsa_circ_WDR78	WDR78	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	down-regulated	RNA-seq	"hsa_circ_0006677 is down-regulated in TNBC in RNA-seq and was analyzed for predicted RBP interactions, implicating a possible role in gene regulatory processes."	0.1768
35805051	Cancers	2022	Triple-Negative Breast Cancer circRNAome Reveals Hsa_circ_0072309 as a Potential Risk Biomarker.	hsa_circ_0008599	circ_0008599	hsa_circ_MIR31HG	MIR31HG	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	down-regulated	RNA-seq	"hsa_circ_0008599 is down-regulated in TNBC in RNA-seq, but its RT-qPCR validation direction was inconsistent in FFPE samples; it was still analyzed for predicted RBP interactions."	0.1768
35805051	Cancers	2022	Triple-Negative Breast Cancer circRNAome Reveals Hsa_circ_0072309 as a Potential Risk Biomarker.	hsa_circ_0009043	circ_0009043	hsa_circ_EXOC6B	EXOC6B	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0009043 is down-regulated in TNBC in RNA-seq and was differentially expressed in frozen-tissue RT-qPCR validation; it was also analyzed via predicted circRNA_RBP interactions.	0.4032
35805051	Cancers	2022	Triple-Negative Breast Cancer circRNAome Reveals Hsa_circ_0072309 as a Potential Risk Biomarker.	hsa_circ_0000479		hsa_circ_EPSTI1	EPSTI1	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000479 is up-regulated in TNBC (RNA-seq) and was validated as differentially expressed in FFPE samples by RT-qPCR; it was also analyzed for predicted circRNA_RBP interactions (e.g., AGO2)."	0.4032
35805051	Cancers	2022	Triple-Negative Breast Cancer circRNAome Reveals Hsa_circ_0072309 as a Potential Risk Biomarker.	hsa_circ_0001821				triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	down-regulated	RNA-seq	hsa_circ_0001821 is down-regulated in BRCA1 germline mutated TNBC compared with WT TNBC based on RNA-seq differential expression analysis.	0.1768
35805051	Cancers	2022	Triple-Negative Breast Cancer circRNAome Reveals Hsa_circ_0072309 as a Potential Risk Biomarker.	hsa_circ_0001550				triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RNA-seq	hsa_circ_0001550 is up-regulated in BRCA1 germline mutated TNBC compared with WT TNBC based on RNA-seq differential expression analysis.	0.1768
35805051	Cancers	2022	Triple-Negative Breast Cancer circRNAome Reveals Hsa_circ_0072309 as a Potential Risk Biomarker.	hsa_circ_0001178	circ_0001178			triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RNA-seq	circ_0001178 is up-regulated in BRCA1 germline mutated TNBC compared with WT TNBC based on RNA-seq differential expression analysis.	0.1768
35805051	Cancers	2022	Triple-Negative Breast Cancer circRNAome Reveals Hsa_circ_0072309 as a Potential Risk Biomarker.	hsa_circ_0006376	circ_0006376			triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RNA-seq	circ_0006376 is up-regulated in BRCA1 germline mutated TNBC compared with WT TNBC based on RNA-seq differential expression analysis.	0.1768
35805051	Cancers	2022	Triple-Negative Breast Cancer circRNAome Reveals Hsa_circ_0072309 as a Potential Risk Biomarker.	hsa_circ_0023942	circ_0023942			triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RNA-seq	circ_0023942 is up-regulated in BRCA1 germline mutated TNBC compared with WT TNBC based on RNA-seq differential expression analysis.	0.1768
35805051	Cancers	2022	Triple-Negative Breast Cancer circRNAome Reveals Hsa_circ_0072309 as a Potential Risk Biomarker.	hsa_circ_0001314	circ_0001314			triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RNA-seq	circ_0001314 is up-regulated in BRCA1 germline mutated TNBC compared with WT TNBC based on RNA-seq differential expression analysis.	0.1768
35805051	Cancers	2022	Triple-Negative Breast Cancer circRNAome Reveals Hsa_circ_0072309 as a Potential Risk Biomarker.	hsa_circ_0001789	circ_0001789			triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RNA-seq	circ_0001789 is up-regulated in BRCA1 germline mutated TNBC compared with WT TNBC based on RNA-seq differential expression analysis.	0.1768
35805051	Cancers	2022	Triple-Negative Breast Cancer circRNAome Reveals Hsa_circ_0072309 as a Potential Risk Biomarker.	hsa_circ_0000343	circ_0000343			triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RNA-seq	circ_0000343 is up-regulated in BRCA1 germline mutated TNBC compared with WT TNBC based on RNA-seq differential expression analysis.	0.1768
35805051	Cancers	2022	Triple-Negative Breast Cancer circRNAome Reveals Hsa_circ_0072309 as a Potential Risk Biomarker.	hsa_circ_0072309		hsa_circ_TPTEP1	TPTEP1	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	down-regulated	RNA-seq	"chr22:17117929-17119630 is a novel, unannotated circRNA that is down-regulated in TNBC versus matched adjacent tissue based on RNA-seq differential expression."	0.1768
35812182	Journal of Cancer	2022	Hsa_circ_0007312 Promotes Third-Generation Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Resistance through Pyroptosis and Apoptosis via the MiR-764/MAPK1 Axis in Lung Adenocarcinoma Cells.	hsa_circ_0007312	circ7312 / circ-0007312			lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"hsa_circ_0007312 (circ7312) is upregulated in LUAD tumor tissues and is associated with poor prognosis. Functionally, circ7312 promotes osimertinib (third-generation EGFR-TKI) resistance and tumor aggressiveness by sponging miR-764 to upregulate MAPK1, thereby reducing pyroptosis and apoptosis; circ7312 knockdown restores drug sensitivity in vitro and in a xenograft model."	0.7126
35813480	International journal of biological sciences	2022	Hypoxia-inducible CircPFKFB4 Promotes Breast Cancer Progression by Facilitating the CRL4DDB2 E3 Ubiquitin Ligase-mediated p27 Degradation.	hsa_circ_0124008	circPFKFB4	hsa_circ_PFKFB4	PFKFB4	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circPFKFB4 (hsa_circ_0124008) is induced by hypoxia in BC and is up-regulated in tumors, where high expression predicts poor prognosis. It promotes BC cell proliferation and tumor growth by binding DDB1/DDB2 to enhance CRL4DDB2 assembly and drive p27 ubiquitination and degradation, facilitating cell-cycle progression under hypoxia."	0.904
35813866	Journal of oncology	2022	Circ_0110940 Exerts an Antiapoptotic and Pro-Proliferative Effect in Gastric Cancer Cells via the miR-1178-3p/SLC38A6 Axis.	hsa_circ_0110940	circ_0110940	hsa_circ_CDK11B	CDK11B	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_0110940 is up-regulated in gastric cancer cell lines and functions as an oncogenic circRNA by promoting proliferation and inhibiting apoptosis. Mechanistically, it binds and suppresses miR-1178-3p, thereby increasing SLC38A6 expression (circ_0110940/miR-1178-3p/SLC38A6 axis)."	0.6945
35814499	Molecular vision	2022	Comprehensive circular RNA expression profiling with associated ceRNA network in orbital venous malformation.	hsa_circ_0000437	circRNA_2189			Orbital venous malformation / OVM	MONDO:0004634	vein disorder	dysregulated	RT-qPCR; RNA-seq	hsa_circ_0000437 (circRNA_2189) is a differentially expressed circRNA in OVM identified by RNA-seq and its dysregulation was validated by RT-qPCR in additional clinical tissue samples. The paper uses it mainly as a representative circRNA to confirm reliability of the sequencing results rather than to define a specific mechanistic axis.	0.4032
35814499	Molecular vision	2022	Comprehensive circular RNA expression profiling with associated ceRNA network in orbital venous malformation.	hsa_circ_0000745	circRNA_3654			Orbital venous malformation / OVM	MONDO:0004634	vein disorder	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0000745 (circRNA_3654) is reported as a differentially expressed circRNA in OVM, detected by RNA-seq and validated by RT-qPCR in additional clinical tissue samples. It serves as a representative circRNA supporting the reliability of the circRNA profiling dataset."	0.4032
35814499	Molecular vision	2022	Comprehensive circular RNA expression profiling with associated ceRNA network in orbital venous malformation.	hsa_circ_0003856	circRNA_3192			Orbital venous malformation / OVM	MONDO:0004634	vein disorder	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0003856 (circRNA_3192) is identified as a differentially expressed circRNA in OVM and its expression change is confirmed by RT-qPCR, supporting the reliability of the RNA-seq circRNA differential-expression analysis in clinical tissues."	0.4032
35814499	Molecular vision	2022	Comprehensive circular RNA expression profiling with associated ceRNA network in orbital venous malformation.		circRNA_8224			Orbital venous malformation / OVM	MONDO:0004634	vein disorder	up-regulated	RNA-seq	"circRNA_8224 is upregulated in OVM and is included as a core node in a constructed circRNA_miRNA_mRNA ceRNA network (up circRNA_down miRNAs_up mRNAs), suggesting a potential sponge-based regulatory role in OVM. No specific miRNA/mRNA targets are named in the provided text."	0.348
35814499	Molecular vision	2022	Comprehensive circular RNA expression profiling with associated ceRNA network in orbital venous malformation.		circRNA_1678			Orbital venous malformation / OVM	MONDO:0004634	vein disorder	down-regulated	RNA-seq	"circRNA_1678 is downregulated in OVM and is used to build a circRNA_miRNA_mRNA ceRNA network (down circRNA_up miRNAs_down mRNA), implying a potential ceRNA-mediated regulatory role in OVM. Specific downstream miRNAs/mRNAs are not provided in the given text."	0.348
35817771	Cell death & disease	2022	Exosomal circWDR62 promotes temozolomide resistance and malignant progression through regulation of the miR-370-3p/MGMT axis in glioma.	hsa_circ_0050688	circWDR62	hsa_circ_WDR62	WDR62	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; Microarray	"circWDR62 (hsa_circ_0050688) is upregulated in TMZ-resistant glioma cells, their exosomes, and in patient serum exosomes/tumor tissues, and high expression correlates with poorer survival. Functionally it promotes TMZ chemoresistance and malignant behaviors (proliferation, migration, invasion) and can be transferred via exosomes to confer resistance to sensitive cells. Mechanistically it acts as a ceRNA by sponging miR-370-3p to increase MGMT expression."	0.8152
35819256	Annals of medicine	2022	Urinary exosomes derived circRNAs as biomarkers for chronic renal fibrosis.	hsa_circ_0036649		hsa_circ_AKAP13	AKAP13	chronic kidney disease / CKD	MONDO:0005300	chronic kidney disease	down-regulated	RT-qPCR; Microarray	"Urinary exosomal hsa_circ_0036649 is down-regulated in renal fibrotic CKD patients and correlates with renal function indices and pathological fibrosis scores. It shows diagnostic potential for renal fibrosis (AUC 0.706), but no molecular mechanism was experimentally defined in this study."	0.5047
35821018	Cell death discovery	2022	CircRNA mmu_circ_0000021 regulates microvascular function via the miR-143-3p/NPY axis and intracellular calcium following ischemia/reperfusion injury.	mmu_circ_0000021	circ_0000021 			cardiac ischemia-reperfusion injury / cardiac I/R injury	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR; RNA-seq	"mmu_circ_0000021 is up-regulated after myocardial ischemia/reperfusion and aggravates microvascular dysfunction. It binds miR-143-3p to increase NPY, thereby enhancing intracellular Ca2+ overload and promoting cardiomyocyte apoptosis; knockdown improves microvascular integrity/perfusion and cardiac function."	0.7452
35821222	Cell death & disease	2022	"Novel roles of LSECtin in gastric cancer cell adhesion, migration, invasion, and lymphatic metastasis."	hsa_circ_0077417	circFBXL4	hsa_circ_FBXL4	FBXL4	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"In gastric cancer models, circFBXL4 is downregulated by LSECtin and acts as a ceRNA sponge for miR-146a-5p, thereby relieving miR-146a-5p-mediated repression of STAT1. Through this circFBXL4/miR-146a-5p/STAT1 axis, circFBXL4 suppresses GC cell proliferation, migration and invasion and counteracts LSECtin-driven malignant behaviors."	0.8207
35821230	Cell death discovery	2022	Circular RNA circLDLR facilitates cancer progression by altering the miR-30a-3p/SOAT1 axis in colorectal cancer.	hsa_circ_0006877	circLDLR / circ_0006877	hsa_circ_LDLR	LDLR	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"circLDLR is up-regulated in colorectal cancer and promotes malignant progression (proliferation, migration/invasion, tumor growth and lung metastasis). It acts as a ceRNA by sponging miR-30a-3p to increase SOAT1 expression, which is linked to elevated cellular cholesterol (T-CHO and LDL-C). High circLDLR expression correlates with advanced clinical features and poorer overall survival."	0.8932
35831872	Biomarker research	2022	circCYP24A1 promotes Docetaxel resistance in prostate Cancer by Upregulating ALDH1A3.	hsa_circ_0060927	circCYP24A1	hsa_circ_CYP24A1	CYP24A1	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circCYP24A1 is upregulated in docetaxel-resistant prostate cancer and reduces DTX chemosensitivity in vitro and in vivo. It promotes chemoresistance by sponging miR-1301-3p to upregulate ALDH1A3 and activate PI3K/AKT/mTOR signaling, and its expression predicts DTX response in a patient cohort."	0.8932
35832649	Journal of immunology research	2022	LMX1B Activated Circular RNA GFRA1 Modulates the Tumorigenic Properties and Immune Escape of Prostate Cancer.		circGFRA1 / hsa_circ_005239	hsa_circ_GFRA1	GFRA1	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	"circGFRA1 is upregulated in prostate cancer tissues/cell lines and acts as an oncogenic circRNA that promotes proliferation, migration, and immune escape. Mechanistically, LMX1B activates circGFRA1 transcription, and circGFRA1 sponges miR-3064-5p to upregulate HECTD1."	0.7998
35833065	Contrast media & molecular imaging	2022	Investigation of the Mechanism of hsa_circ_000 1429 Adsorbed miR-205 to Regulate KDM4A and Promote Breast Cancer Metastasis.	hsa_circ_0001429				breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"hsa_circ_0001429 is up-regulated in breast cancer cell lines and promotes malignant phenotypes (proliferation, migration, invasion) while inhibiting apoptosis. Mechanistically, it functions as a ceRNA by binding miR-205 (with AGO2 association) to regulate the miR-205 target KDM4A."	0.6306
35836485	Oncology letters	2022	"Circular RNA 0001666 inhibits colorectal cancer cell proliferation, invasion and stemness by inactivating the Wnt/beta-catenin signaling pathway and targeting microRNA-1229."	hsa_circ_0001666	circular RNA 0001666 / circ_0001666	hsa_circ_FAM120B	FAM120B	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"circ_0001666 is down-regulated in CRC cell lines and functions as a tumor suppressor in vitro. It binds miR-1229, reduces miR-1229 levels, and inactivates Wnt/beta-catenin signaling (with effects involving CXCR5), thereby inhibiting proliferation, invasion and stemness and promoting apoptosis."	0.6494
35840930	Molecular cancer	2022	"Circular RNA circPOLR2A promotes clear cell renal cell carcinoma progression by facilitating the UBE3C-induced ubiquitination of PEBP1 and, thereby, activating the ERK signaling pathway."	hsa_circ_0000741	hsa_circRNA_092437 / circPOLR2A	hsa_circ_POLR2A	POLR2A	clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR; Microarray	"circPOLR2A is upregulated in clear cell renal cell carcinoma and promotes malignant phenotypes (proliferation, migration, invasion, angiogenesis, metastasis) while inhibiting apoptosis. Mechanistically, it serves as a scaffold for UBE3C and PEBP1 to enhance UBE3C-mediated ubiquitination and proteasomal degradation of PEBP1, activating ERK signaling; its abundance is regulated by m6A modification and YTHDF2."	0.8627
35840955	BMC musculoskeletal disorders	2022	Construction of a circular RNA-based competing endogenous RNA network to screen biomarkers related to intervertebral disc degeneration.		circRNA_100086			intervertebral disc degeneration / IDD	MONDO:0011385	intervertebral disk degenerative disorder	up-regulated	Microarray	"circRNA_100086 is upregulated in IDD microarray data and was incorporated into an IDD-related ceRNA network. It is predicted to act as a ceRNA by sponging miR-509-3p to regulate targets including MAPK1 (and TGFBR2), implicating pathways such as TGF-beta and FoxO signaling in IDD."	0.1768
35840955	BMC musculoskeletal disorders	2022	Construction of a circular RNA-based competing endogenous RNA network to screen biomarkers related to intervertebral disc degeneration.		circRNA_000200			intervertebral disc degeneration / IDD	MONDO:0011385	intervertebral disk degenerative disorder	up-regulated	Microarray	"circRNA_000200 is upregulated in IDD microarray data and is included in an IDD-related ceRNA network. It is predicted to sponge miR-185-5p and thereby regulate TGFB1 and other targets, potentially linking to inflammatory processes and pathways including TGF-beta and FoxO signaling in IDD."	0.1768
35840955	BMC musculoskeletal disorders	2022	Construction of a circular RNA-based competing endogenous RNA network to screen biomarkers related to intervertebral disc degeneration.		circRNA_104308			intervertebral disc degeneration / IDD	MONDO:0011385	intervertebral disk degenerative disorder	up-regulated	Microarray	"circRNA_104308 is upregulated in IDD microarray data and is included in an IDD-related ceRNA network. It is predicted to sponge miR-185-5p and thereby regulate TGFB1 and additional mRNAs, potentially contributing to IDD via inflammation-related biology and pathways including TGF-beta and FoxO signaling."	0.1768
35840955	BMC musculoskeletal disorders	2022	Construction of a circular RNA-based competing endogenous RNA network to screen biomarkers related to intervertebral disc degeneration.		circRNA_400090			intervertebral disc degeneration / IDD	MONDO:0011385	intervertebral disk degenerative disorder	up-regulated	Microarray	"circRNA_400090 is upregulated in IDD microarray data and is included in an IDD-related ceRNA network. It is predicted to sponge miR-486-5p to regulate FOXO1 and SMAD2 (and CCND2), linking it to FoxO signaling-related biology in IDD."	0.1768
35840974	Molecular cancer	2022	CircBCAR3 accelerates esophageal cancer tumorigenesis and metastasis via sponging miR-27a-3p.	hsa_circ_0007624	CircBCAR3 	hsa_circ_BCAR3	BCAR3	Esophageal cancer / EC	MONDO:0007576	esophageal cancer	up-regulated	RT-qPCR	"circBCAR3 is upregulated in esophageal cancer and further induced by hypoxia. It promotes proliferation, migration, invasion, tumor growth/metastasis and enhances ferroptosis, mainly via a ceRNA mechanism (circBCAR3/miR-27a-3p/TNPO1); its biogenesis is promoted by QKI, which is transcriptionally activated by hypoxia-induced E2F7."	0.8279
35841021	BMC women's health	2022	RNA-seq reveals co-dysregulated circular RNAs in the adenomyosis eutopic endometrium and endometrial-myometrial interface.	hsa_circ_0002144				adenomyosis	MONDO:0010888	adenomyosis	up-regulated	RNA-seq	"hsa_circ_0002144 is co-upregulated in adenomyosis eutopic endometrium and EMI. The study predicts that it participates in a circRNA_miRNA_mRNA ceRNA network whose target genes are enriched in MAPK signaling, potentially contributing to endometrial invagination and adenomyosis progression."	0.4276
35841021	BMC women's health	2022	RNA-seq reveals co-dysregulated circular RNAs in the adenomyosis eutopic endometrium and endometrial-myometrial interface.	hsa_circ_0005806				adenomyosis	MONDO:0010888	adenomyosis	up-regulated	RNA-seq	"hsa_circ_0005806 is co-upregulated in adenomyosis eutopic endometrium and EMI. It is included in a predicted circRNA_miRNA_mRNA ceRNA network, with downstream targets enriched in MAPK signaling, suggesting a potential role in adenomyosis development."	0.4276
35841021	BMC women's health	2022	RNA-seq reveals co-dysregulated circular RNAs in the adenomyosis eutopic endometrium and endometrial-myometrial interface.	hsa_circ_0079536				adenomyosis	MONDO:0010888	adenomyosis	down-regulated	RNA-seq	"hsa_circ_0079536 is co-downregulated in adenomyosis eutopic endometrium and EMI. It is part of a predicted circRNA_miRNA_mRNA ceRNA network enriched for MAPK signaling-related targets, suggesting potential involvement in adenomyosis-related tissue activity changes."	0.4276
35841021	BMC women's health	2022	RNA-seq reveals co-dysregulated circular RNAs in the adenomyosis eutopic endometrium and endometrial-myometrial interface.	hsa_circ_0024766				adenomyosis	MONDO:0010888	adenomyosis	down-regulated	RNA-seq	"hsa_circ_0024766 is co-downregulated in adenomyosis eutopic endometrium and EMI. It was incorporated into a predicted circRNA_miRNA_mRNA ceRNA network whose target genes are enriched for MAPK signaling, implying a possible role in adenomyosis progression."	0.4276
35842667	Journal of translational medicine	2022	The abnormal expression of circ-ARAP2 promotes ESCC progression through regulating miR-761/FOXM1 axis-mediated stemness and the endothelial-mesenchymal transition.	hsa_circ_0069399	circ-ARAP2	hsa_circ_ARAP2	ARAP2	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circ-ARAP2 (hsa_circ_0069399), derived from ARAP2, is up-regulated in ESCC tissues and cell lines. Its knockdown suppresses proliferation, tumor growth and metastasis, and reduces stemness/EMT phenotypes by acting as a ceRNA that sponges miR-761 to increase FOXM1."	0.6977
35844799	International journal of biological sciences	2022	CircFAT1 Promotes Lung Adenocarcinoma Progression by Sequestering miR-7 from Repressing IRS2-ERK-mediated CCND1 Expression.	hsa_circ_0001461	CircFAT1	hsa_circ_FAT1	FAT1	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Northern Blot; RNA-seq	"circFAT1 is upregulated in LUAD tissues and promotes LUAD cell proliferation and xenograft tumor growth. Mechanistically, it acts as a cytoplasmic ceRNA that sponges miR-7, leading to increased IRS2 and activation of ERK1/2 phosphorylation with elevated CCND1, facilitating G1/S progression. circFAT1 knockdown improves cisplatin (DDP) treatment efficacy in vitro and in a cell line-derived xenograft model."	0.8074
35844837	Gastroenterology research and practice	2022	Differential Expression Profiles of mRNA and Noncoding RNA and Analysis of Competitive Endogenous RNA Regulatory Networks in Nonalcoholic Steatohepatitis.	hsa_circ_0000566				Nonalcoholic steatohepatitis / NASH	MONDO:0007027	metabolic dysfunction-associated steatohepatitis	dysregulated	Microarray	"hsa_circ_0000566 was identified as a differentially expressed circRNA in NASH liver tissue microarray data and included in a predicted circRNA_miRNA_mRNA ceRNA network, where it potentially binds hsa-miR-885-5p and hsa-miR-142-3p and is linked to LOX."	0.1768
35845080	Frontiers in cardiovascular medicine	2022	Integrated Analysis of circRNA-miRNA-mRNA-Mediated Network and Its Potential Function in Atrial Fibrillation.	hsa_circ_0070391	hsa_circRNA_102461	hsa_circ_KLHL8	KLHL8	atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	up-regulated	RT-qPCR; Microarray	"hsa_circ_0070391 is up-regulated in AF plasma and is positively associated with left atrial fibrosis. It is proposed to function in an AF ceRNA network by sponging miR-630/miR-21/miR-1305 and affecting multiple downstream mRNAs. Clinically, it shows high diagnostic performance for AF and higher expression indicates worse post-ablation atrial tachyarrhythmia-free outcome."	0.5534
35845080	Frontiers in cardiovascular medicine	2022	Integrated Analysis of circRNA-miRNA-mRNA-Mediated Network and Its Potential Function in Atrial Fibrillation.	hsa_circ_0003935	hsa_circRNA_103693	hsa_circ_CACNA1A	CACNA1A	atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	down-regulated	RT-qPCR; Microarray	"hsa_circ_0003935 is down-regulated in AF plasma and has diagnostic value for AF versus controls. In the constructed ceRNA network, it is linked to miR-223 and predicted downstream mRNAs, but it is not associated with left atrial fibrosis in this cohort."	0.5047
35847361	Journal of oncology	2022	Circular RNA circACAP2 Suppresses Ferroptosis of Cervical Cancer during Malignant Progression by miR-193a-5p/GPX4.		circACAP2 / circRNA circACAP2	hsa_circ_ACAP2	ACAP2	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"In cervical cancer cells and patient tumor tissues, circACAP2 is upregulated and functions as a ceRNA that sponges miR-193a-5p to increase GPX4 expression. Through the miR-193a-5p/GPX4 axis, circACAP2 promotes cell viability and suppresses ferroptosis-related phenotypes (lipid ROS and iron accumulation)."	0.6672
35847962	Frontiers in oncology	2022	CircKIF5B Promotes Hepatocellular Carcinoma Progression by Regulating the miR-192 Family/XIAP Axis.	hsa_circ_0018105	circKIF5B	hsa_circ_KIF5B	KIF5B	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circKIF5B is up-regulated in hepatocellular carcinoma tissues and cell lines and promotes malignant phenotypes (proliferation, migration/invasion, metastasis, tumor growth). Mechanistically, it acts as a ceRNA that sponges miR-192 and miR-215 to increase XIAP expression, and high circKIF5B levels are associated with worse patient outcomes."	0.887
35852149	Bioscience reports	2022	"Differential expression profile of mRNAs, lncRNAs, and circRNAs reveals potential molecular mechanism in breast cancer."		circNFIX	hsa_circ_NFIX	NFIX	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RNA-seq	circNFIX is up-regulated in breast cancer tissues and is highlighted in the constructed ceRNA network. It is proposed to act as a ceRNA associated with has-miR-6794-5p and to regulate MMP9 and fatty acid metabolism-related processes in breast cancer.	0.1768
35854245	BMC cancer	2022	"circ_0000045 promotes proliferation, migration, and invasion of head and neck squamous cell carcinomas via regulating HSP70 and MAPK pathway."	hsa_circ_0000045	circ_0000045			Head and neck squamous cell carcinoma / HNSCC	MONDO:0010150	head and neck squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ_0000045 (hsa_circ_0000045) is up-regulated in HNSCC/oral tongue squamous cell carcinoma tissues and promotes HNSCC cell proliferation, migration, and invasion. Mechanistically, it associates with RNA-binding proteins (including HSP70/HSPA8), represses HSP70 expression, and enhances MAPK signaling components JNK2 and P38."	0.7795
35854778	Contrast media & molecular imaging	2022	Exosome-Derived Circ_0094343 Promotes Chemosensitivity of Colorectal Cancer Cells by Regulating Glycolysis via the miR-766-5p/TRIM67 Axis.	hsa_circ_0094343	circ_0094343 / circPTEN	hsa_circ_PTEN	PTEN	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	circ_0094343 (circPTEN) is down-regulated in colorectal cancer tissues (including chemotherapy-resistant and metastatic samples). Exosome-delivered circ_0094343 suppresses CRC cell proliferation/clone formation and glycolysis and increases sensitivity to multiple chemotherapeutics by sponging miR-766-5p to derepress TRIM67 (circ_0094343/miR-766-5p/TRIM67 axis).	0.6996
35858900	Molecular cancer	2022	CircGPR137B/miR-4739/FTO feedback loop suppresses tumorigenesis and metastasis of hepatocellular carcinoma.	hsa_circ_0017114	circGPR137B / circ_0017114	hsa_circ_GPR137B	GPR137B	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; ISH; Microarray	"circGPR137B is down-regulated in HCC and functions as a tumor suppressor. It sponges miR-4739 to relieve repression of FTO, while FTO demethylates circGPR137B (m6A) and enhances circGPR137B expression, forming a positive feedback loop that inhibits proliferation, invasion, and metastasis."	0.8846
35860558	Frontiers in oncology	2022	Multi-Omics Integration-Based Prioritisation of Competing Endogenous RNA Regulation Networks in Small Cell Lung Cancer: Molecular Characteristics and Drug Candidates.			hsa_circ_HLA-B	HLA-B	small cell lung cancer / SCLC	MONDO:0008433	small cell lung carcinoma	down-regulated	RNA-seq	"This study prioritised circRNA-hsa_HLA-B_1 as a down-regulated plasma circRNA in SCLC. It was integrated into a ceRNA subnetwork, where it may sponge hsa-miR-6747-3p to support CSF3R expression and sponge hsa-miR-4525 to relieve repression of GAA."	0.1768
35860558	Frontiers in oncology	2022	Multi-Omics Integration-Based Prioritisation of Competing Endogenous RNA Regulation Networks in Small Cell Lung Cancer: Molecular Characteristics and Drug Candidates.		hsa_VEGFC_8	hsa_circ_VEGFC	VEGFC	small cell lung cancer / SCLC	MONDO:0008433	small cell lung carcinoma	down-regulated	RNA-seq	This study prioritised hsa_VEGFC_8 as a down-regulated plasma circRNA in SCLC. It was placed in a circRNA_miRNA_mRNA ceRNA axis (hsa_VEGFC_8_hsa-miR-6747-3p_CSF3R) potentially relieving miRNA inhibition of CSF3R.	0.1768
35864511	Journal of translational medicine	2022	Engineered exosome-mediated delivery of circDIDO1 inhibits gastric cancer progression via regulation of MiR-1307-3p/SOCS2 Axis.		circDIDO1	hsa_circ_DIDO1	DIDO1	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; RNA-seq	"circDIDO1 is down-regulated in gastric cancer and functions as a tumor suppressor. Mechanistically, it sponges miR-1307-3p to upregulate SOCS2, thereby inhibiting proliferation/migration/invasion and promoting apoptosis. RGD-modified exosomes delivering circDIDO1 show anti-tumor efficacy in vitro and in a cell line-derived xenograft model."	0.7302
35864552	Journal of experimental & clinical cancer research : CR	2022	Dysregulation and prometastatic function of glycosyltransferase C1GALT1 modulated by cHP1BP3/ miR-1-3p axis in bladder cancer.		circRNA cHP1BP3	hsa_circ_HP1BP3	HP1BP3	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; RNA-seq	"cHP1BP3 is upregulated in bladder cancer and mainly localizes to the cytoplasm. It acts as a ceRNA sponge for miR-1-3p, relieving repression of C1GALT1 and thereby promoting malignant phenotypes; silencing cHP1BP3 suppresses proliferation, migration, and metastasis in BLCA models."	0.8363
35864990	Frontiers in neuroscience	2022	Screening of Human Circular RNAs as Biomarkers for Early Onset Detection of Alzheimer's Disease.		hsa-circRNA_001481	hsa_circ_EMB	EMB	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_001481 is up-regulated in blood from early AD continuum stages (SCD/aMCI) and is proposed as a non-invasive early diagnostic biomarker. Mechanistically, it acts as a ceRNA by sponging miRNAs (validated for hsa-miR-548m, hsa-miR-1252-5p, and hsa-miR-4644), thereby modulating EMB expression."	0.5922
35864990	Frontiers in neuroscience	2022	Screening of Human Circular RNAs as Biomarkers for Early Onset Detection of Alzheimer's Disease.		hsa_circRNA_000479	hsa_circ_EPSTI1	EPSTI1	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_000479 is up-regulated in blood across AD continuum stages and is suggested as an early, non-invasive screening biomarker. It likely functions via a ceRNA mechanism, sponging miRNAs (validated for hsa-miR-942-5p, hsa-miR-4753-3p, and hsa-miR-6739-3p) to regulate EPSTI1 expression."	0.5922
35865405	Mediterranean journal of hematology and infectious diseases	2022	CircCTNNA1 is Upregulated in Mantle Cell Lymphoma and Predicts Poor Survival by Sponging miR-34a to Increase Cell Proliferation.		circCTNNA1	hsa_circ_CTNNA1	CTNNA1	mantle cell lymphoma / MCL	MONDO:0018876	mantle cell lymphoma	up-regulated	RT-qPCR	"circCTNNA1 is up-regulated in mantle cell lymphoma and functions as an oncogenic circRNA. It directly binds (sponges) miR-34a and promotes MCL cell proliferation, and higher circCTNNA1 expression predicts poorer overall survival."	0.7083
35865464	Frontiers in oncology	2022	CircLONP2 Accelerates Esophageal Squamous Cell Carcinoma Progression via Direct MiR-27b-3p-ZEB1 Axis.		circLONP2	hsa_circ_LONP2	LONP2	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"circLONP2 is up-regulated in ESCC tissues/cell lines and functions as an oncogenic circRNA that promotes proliferation, migration and metastasis. Mechanistically, it sponges miR-27b-3p to de-repress ZEB1, thereby promoting EMT. High circLONP2 expression is associated with worse OS/DFS and may serve as a prognostic biomarker."	0.7587
35871061	Cell death & disease	2022	UPF1/circRPPH1/ATF3 feedback loop promotes the malignant phenotype and stemness of GSCs.	hsa_circ_0000512	circRPPH1	hsa_circ_RPPH1	RPPH1	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; Northern Blot; ISH; RNA-seq	"circRPPH1 is up-regulated in GBM/GSCs and promotes malignant phenotypes (proliferation, invasion, self-renewal and tumorigenesis). UPF1 binds circRPPH1 to maintain its stability, while circRPPH1 binds ATF3 to stabilize it and promote nuclear translocation; ATF3 transcriptionally upregulates UPF1 and Nestin, forming a positive feedback loop and enhancing TGF-beta/SMAD signaling."	0.8941
35871166	Cell death discovery	2022	Exosomal circPABPC1 promotes colorectal cancer liver metastases by regulating HMGA2 in the nucleus and BMP4/ADAM19 in the cytoplasm.	hsa_circ_0085159	circPABPC1 	hsa_circ_PABPC1	PABPC1	colorectal carcinoma / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circPABPC1 is up-regulated in CRC tissues and serum/cell-derived exosomes and promotes CRC proliferation and liver metastasis. It functions in the nucleus by recruiting KDM4C to activate HMGA2 transcription, and in the cytoplasm as a ceRNA sponging miR-874/miR-1292 to upregulate ADAM19 and BMP4, thereby promoting EMT-associated metastasis."	0.8817
35872625	Balkan medical journal	2022	Circ_0010235 Regulates HOXA10 Expression to Promote Malignant Phenotypes and Radioresistance in Non-small Cell Lung Cancer Cells Via Decoying miR-588.	hsa_circ_0010235	circ_0010235			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0010235 is up-regulated in NSCLC tissues and cell lines and promotes proliferation, invasion, migration and radioresistance while inhibiting apoptosis and radiosensitivity. Mechanistically, it functions as a sponge for miR-588 to relieve repression of HOXA10, forming a circ_0010235/miR-588/HOXA10 axis."	0.8299
35872921	Frontiers in cardiovascular medicine	2022	Comprehensive Analysis of circRNA-miRNA-mRNA Regulatory Network and Novel Potential Biomarkers in Acute Myocardial Infarction.	hsa_circ_0023461	hsa_circRNA_023461	hsa_circ_ARAP1	ARAP1	acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR; Microarray	"hsa_circ_0023461 is up-regulated in AMI and in an AC16 hypoxia model. It is proposed to function as a ceRNA by sponging hsa-miR-589-5p to influence ATP2B2 expression, and is suggested as a potential AMI biomarker."	0.3684
35872921	Frontiers in cardiovascular medicine	2022	Comprehensive Analysis of circRNA-miRNA-mRNA Regulatory Network and Novel Potential Biomarkers in Acute Myocardial Infarction.	hsa_circ_0004561				acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR; Microarray	hsa_circ_0004561 is up-regulated in the AC16 hypoxia model. It is proposed to participate in AMI via a putative ceRNA axis involving hsa-miR-298 and ANK2 and is listed among potential AMI biomarkers.	0.3684
35872921	Frontiers in cardiovascular medicine	2022	Comprehensive Analysis of circRNA-miRNA-mRNA Regulatory Network and Novel Potential Biomarkers in Acute Myocardial Infarction.	hsa_circ_0001147				acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	down-regulated	RT-qPCR; Microarray	hsa_circ_0001147 is down-regulated in the AC16 hypoxia model and is listed among potential AMI biomarkers. The paper proposes a ceRNA relationship hsa_circ_0001147/hsa-miR-204-5p/GPM6A that may be involved in myocardial infarction.	0.3684
35872921	Frontiers in cardiovascular medicine	2022	Comprehensive Analysis of circRNA-miRNA-mRNA Regulatory Network and Novel Potential Biomarkers in Acute Myocardial Infarction.	hsa_circ_0004771	hsa_circRNA_103110	hsa_circ_NRIP1	NRIP1	acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	down-regulated	RT-qPCR; Microarray	"hsa_circ_0004771 is down-regulated in AMI blood microarray data and in an AC16 hypoxia model. The study proposes a ceRNA axis hsa_circ_0004771/hsa-miR-629-3p/SRSF1 potentially involved in myocardial infarction, and lists it as a potential biomarker."	0.3684
35872921	Frontiers in cardiovascular medicine	2022	Comprehensive Analysis of circRNA-miRNA-mRNA Regulatory Network and Novel Potential Biomarkers in Acute Myocardial Infarction.	hsa_circ_0061276	hsa_circRNA_103111	hsa_circ_NRIP1	NRIP1	acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	down-regulated	RT-qPCR; Microarray	hsa_circ_0061276 is down-regulated in AMI blood microarray data and in an AC16 hypoxia model. The study proposes a ceRNA axis hsa_circ_0061276/hsa-miR-629-3p/SRSF1 that may be involved in myocardial infarction and suggests it as a potential biomarker.	0.3684
35872921	Frontiers in cardiovascular medicine	2022	Comprehensive Analysis of circRNA-miRNA-mRNA Regulatory Network and Novel Potential Biomarkers in Acute Myocardial Infarction.	hsa_circ_0045519				acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR; Microarray	hsa_circ_0045519 is up-regulated in the AC16 hypoxia model and is suggested as a potential AMI biomarker. The study proposes a ceRNA axis hsa_circ_0045519/hsa-miR-298/ANK2 potentially involved in myocardial infarction.	0.3684
35873383	Journal of inflammation research	2022	Construction of circRNA-Mediated Immune-Related ceRNA Network and Identification of Circulating circRNAs as Diagnostic Biomarkers in Acute Ischemic Stroke.	hsa_circ_0007364	circPTP4A2	hsa_circ_PTP4A2	PTP4A2	ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; Microarray	"circPTP4A2 (hsa_circ_0007364) is up-regulated in plasma of AIS patients and also elevated in TIA vs healthy controls, supporting its use as a circulating diagnostic/predictive biomarker. Mechanistically, the study predicts a ceRNA axis in which circPTP4A2 sponges hsa-miR-942-5p to influence FCGR3A/FCGR3B within an immune-related network, though functional validation is not performed."	0.5534
35873383	Journal of inflammation research	2022	Construction of circRNA-Mediated Immune-Related ceRNA Network and Identification of Circulating circRNAs as Diagnostic Biomarkers in Acute Ischemic Stroke.	hsa_circ_0045128	circTLK2	hsa_circ_TLK2	TLK2	ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; Microarray	"circTLK2 (hsa_circ_0045128) is up-regulated in plasma of AIS patients and has diagnostic value for AIS. The study predicts an immune-related ceRNA axis where circTLK2 sponges hsa-miR-942-5p to regulate FCGR3A/FCGR3B, but the mechanism is based on bioinformatics prediction rather than functional experiments."	0.5534
35873466	Frontiers in genetics	2022	Identification of circRNA-miRNA-mRNA Regulatory Network and Crucial Signaling Pathway Axis Involved in Tetralogy of Fallot.	hsa_circ_000601				Tetralogy of Fallot / TOF	MONDO:0008542	tetralogy of fallot	up-regulated	Microarray	"This study identified hsa_circ_000601 as an upregulated circRNA in TOF and highlighted a putative ceRNA axis hsa_circ_000601/hsa-miR-148a/BCL2L11. The authors suggest hsa_circ_000601 may sponge hsa-miR-148a, thereby increasing BCL2L11 expression and promoting hypoxia-related cardiomyocyte apoptosis in TOF."	0.1768
35873481	Frontiers in genetics	2022	RNA Sequencing Reveals the Expression Profiles of circRNAs and Indicates Hsa_circ_0070562 as a Pro-osteogenic Factor in Bone Marrow-Derived Mesenchymal Stem Cells of Patients With Ankylosing Spondylitis.	hsa_circ_0070562	circ_0070562 / circ0070562	hsa_circ_TET2	TET2	ankylosing spondylitis / AS	MONDO:0005306	ankylosing spondylitis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0070562 (from TET2) is up-regulated in osteogenically differentiated AS-BMSCs and promotes osteogenesis, as silencing reduces mineralization and osteogenic markers. Bioinformatics and qPCR-supported relationships suggest it may act via miR-133b and miR-424_5p in connection with the TGF-beta signaling pathway, and it is proposed as a potential biomarker/therapeutic target for AS."	0.695
35873481	Frontiers in genetics	2022	RNA Sequencing Reveals the Expression Profiles of circRNAs and Indicates Hsa_circ_0070562 as a Pro-osteogenic Factor in Bone Marrow-Derived Mesenchymal Stem Cells of Patients With Ankylosing Spondylitis.	hsa_circ_0001493	circ_0001493	hsa_circ_ERBB2IP	ERBB2IP	ankylosing spondylitis / AS	MONDO:0005306	ankylosing spondylitis	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001493 (from ERBB2IP) is down-regulated in osteogenically differentiated AS-BMSCs but functionally promotes osteogenesis in both HD- and AS-BMSCs, since its knockdown reduces mineralization and osteogenic markers. The circRNA-miRNA network with miR-582_3p was supported by qPCR-consistent inverse expression."	0.695
35873481	Frontiers in genetics	2022	RNA Sequencing Reveals the Expression Profiles of circRNAs and Indicates Hsa_circ_0070562 as a Pro-osteogenic Factor in Bone Marrow-Derived Mesenchymal Stem Cells of Patients With Ankylosing Spondylitis.	hsa_circ_0000348	circ_0000348	hsa_circ_FAT3	FAT3	ankylosing spondylitis / AS	MONDO:0005306	ankylosing spondylitis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000348 (from FAT3) is up-regulated in osteogenically differentiated AS-BMSCs. Although predicted to interact with miR-133b in a TGF-beta-related network, its knockdown did not noticeably change mineralization in HD- or AS-BMSCs in this study."	0.695
35873481	Frontiers in genetics	2022	RNA Sequencing Reveals the Expression Profiles of circRNAs and Indicates Hsa_circ_0070562 as a Pro-osteogenic Factor in Bone Marrow-Derived Mesenchymal Stem Cells of Patients With Ankylosing Spondylitis.	hsa_circ_0016408	circ_0016408	hsa_circ_FLVCR1	FLVCR1	ankylosing spondylitis / AS	MONDO:0005306	ankylosing spondylitis	up-regulated	RT-qPCR	"circ_0016408 (host gene FLVCR1) was validated by RT-qPCR to be up-regulated in osteogenically differentiated AS-BMSCs versus HD-BMSCs, but no functional or mechanistic experiments were reported for this circRNA."	0.2995
35873481	Frontiers in genetics	2022	RNA Sequencing Reveals the Expression Profiles of circRNAs and Indicates Hsa_circ_0070562 as a Pro-osteogenic Factor in Bone Marrow-Derived Mesenchymal Stem Cells of Patients With Ankylosing Spondylitis.	hsa_circ_0023231	circ_0023231			ankylosing spondylitis / AS	MONDO:0005306	ankylosing spondylitis	down-regulated	RT-qPCR	"circ_0023231 is down-regulated in osteogenically differentiated AS-BMSCs (validated by qRT-PCR). It was bioinformatically predicted to interact with miR-148a-3p, but no direct functional assays were reported for this circRNA."	0.348
35873481	Frontiers in genetics	2022	RNA Sequencing Reveals the Expression Profiles of circRNAs and Indicates Hsa_circ_0070562 as a Pro-osteogenic Factor in Bone Marrow-Derived Mesenchymal Stem Cells of Patients With Ankylosing Spondylitis.	hsa_circ_0060150	circ_0060150			ankylosing spondylitis / AS	MONDO:0005306	ankylosing spondylitis	down-regulated	RT-qPCR	"circ_0060150 is down-regulated in osteogenically differentiated AS-BMSCs (validated by qRT-PCR). It was predicted to interact with miR-148a-3p, but no direct functional assays were reported."	0.348
35873481	Frontiers in genetics	2022	RNA Sequencing Reveals the Expression Profiles of circRNAs and Indicates Hsa_circ_0070562 as a Pro-osteogenic Factor in Bone Marrow-Derived Mesenchymal Stem Cells of Patients With Ankylosing Spondylitis.	hsa_circ_0073381	circ_0073381	hsa_circ_MCTP1	MCTP1	ankylosing spondylitis / AS	MONDO:0005306	ankylosing spondylitis	down-regulated	RT-qPCR	"circ_0073381 (host gene MCTP1) is down-regulated in osteogenically differentiated AS-BMSCs (validated by qRT-qPCR), and was highlighted as having many predicted miRNA-binding sites, but no specific mechanism or functional assay was reported for this circRNA."	0.348
35873481	Frontiers in genetics	2022	RNA Sequencing Reveals the Expression Profiles of circRNAs and Indicates Hsa_circ_0070562 as a Pro-osteogenic Factor in Bone Marrow-Derived Mesenchymal Stem Cells of Patients With Ankylosing Spondylitis.	hsa_circ_0005389	circ_0005389	hsa_circ_SLC38A10	SLC38A10	ankylosing spondylitis / AS	MONDO:0005306	ankylosing spondylitis	down-regulated	RT-qPCR	"hsa_circ_0005389 (host gene SLC38A10) is down-regulated in osteogenically differentiated AS-BMSCs (validated by qRT-qPCR), with no further functional/mechanistic characterization reported in this study."	0.2995
35873481	Frontiers in genetics	2022	RNA Sequencing Reveals the Expression Profiles of circRNAs and Indicates Hsa_circ_0070562 as a Pro-osteogenic Factor in Bone Marrow-Derived Mesenchymal Stem Cells of Patients With Ankylosing Spondylitis.	hsa_circ_0039402	circ_0039402			ankylosing spondylitis / AS	MONDO:0005306	ankylosing spondylitis	down-regulated	RT-qPCR	circ_0039402 is down-regulated in osteogenically differentiated AS-BMSCs (validated by qRT-qPCR) and predicted to interact with miR-148a-3p; no additional functional data were provided.	0.348
35873481	Frontiers in genetics	2022	RNA Sequencing Reveals the Expression Profiles of circRNAs and Indicates Hsa_circ_0070562 as a Pro-osteogenic Factor in Bone Marrow-Derived Mesenchymal Stem Cells of Patients With Ankylosing Spondylitis.	hsa_circ_0059469	circ_0059469	hsa_circ_TASP1	TASP1	ankylosing spondylitis / AS	MONDO:0005306	ankylosing spondylitis	down-regulated	RT-qPCR	"circ_0059469 (host gene TASP1) is down-regulated in osteogenically differentiated AS-BMSCs (validated by qRT-qPCR), without additional functional/mechanistic validation in this paper."	0.2995
35873481	Frontiers in genetics	2022	RNA Sequencing Reveals the Expression Profiles of circRNAs and Indicates Hsa_circ_0070562 as a Pro-osteogenic Factor in Bone Marrow-Derived Mesenchymal Stem Cells of Patients With Ankylosing Spondylitis.	hsa_circ_0002774	circ_0002774	hsa_circ_RAB11FIP3	RAB11FIP3	ankylosing spondylitis / AS	MONDO:0005306	ankylosing spondylitis	down-regulated	RT-qPCR	"hsa_circ_0002774 (host gene RAB11FIP3) is down-regulated in osteogenically differentiated AS-BMSCs (validated by qRT-qPCR). It was discussed as part of a qPCR-supported inverse-expression pair with miR-424_5p, but no direct functional assays were reported for this circRNA."	0.348
35874179	The application of clinical genetics	2022	"Deregulation of CircANXA2, Circ0075001, and CircFBXW7 Gene Expressions and Their Predictive Value in Egyptian Acute Myeloid Leukemia Patients."		circANXA2 / circ-ANXA2	hsa_circ_ANXA2	ANXA2	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"circANXA2 is up-regulated in AML whole blood and has diagnostic value (AUC 0.824). High circANXA2 associates with adverse clinical features and shorter overall survival, and it is an independent predictor of complete remission achievement. Mechanistically, it is discussed as a miRNA sponge (MiR-23a-5p/miR503-3p) and linked to ANXA2 transcription and chemotherapy sensitivity."	0.4758
35874179	The application of clinical genetics	2022	"Deregulation of CircANXA2, Circ0075001, and CircFBXW7 Gene Expressions and Their Predictive Value in Egyptian Acute Myeloid Leukemia Patients."	hsa_circ_0075001	circ0075001	hsa_circ_NPM1	NPM1	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"circ0075001 is up-regulated in AML whole blood and shows diagnostic value (AUC 0.855). High circ0075001 associates with splenomegaly/hepatomegaly, less differentiated FAB subtypes, adverse cytogenetics, lower CR achievement, and shorter overall survival. Mechanistically, the paper discusses an association with NPM1 expression and TLR-related genes, but does not establish a specific miRNA axis."	0.4758
35874179	The application of clinical genetics	2022	"Deregulation of CircANXA2, Circ0075001, and CircFBXW7 Gene Expressions and Their Predictive Value in Egyptian Acute Myeloid Leukemia Patients."		circFBXW7	hsa_circ_FBXW7	FBXW7	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	down-regulated	RT-qPCR	"circFBXW7 is down-regulated in AML whole blood and can distinguish AML patients from controls (AUC 0.826). The study did not find significant associations between circFBXW7 expression groups and clinical parameters including survival, but discussion cites prior work suggesting a tumor-suppressive effect where depletion increases AML cell proliferation."	0.4187
35874804	Frontiers in cell and developmental biology	2022	Circ_0005918 Sponges miR-622 to Aggravate Intervertebral Disc Degeneration.	hsa_circ_0005918	circ_0005918			Intervertebral disc degeneration / IDD	MONDO:0011385	intervertebral disk degenerative disorder	up-regulated	RT-qPCR	"circ_0005918 is up-regulated in human IDD NP cells/tissues and correlates with disc degeneration severity. Functionally, circ_0005918 promotes NP cell proliferation, ECM degradation (increased MMP-9/MMP-13 and reduced collagen II), and inflammatory cytokine secretion. Mechanistically, it acts as a sponge of miR-622, and miR-622 mimic reverses circ_0005918-driven phenotypes."	0.6479
35874898	Journal of immunology research	2022	hsa_circ_0000518 Facilitates Non-Small-Cell Lung Cancer Progression via Moderating miR-330-3p and Positively Regulating SLC1A5.	hsa_circ_0000518	circ_0000518 / circular RNA_0000518	hsa_circ_RPPH1	RPPH1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0000518 (circ_0000518), derived from the RPPH1 gene, is up-regulated in NSCLC tissues and cell lines and mainly localizes to the cytoplasm. It promotes malignant phenotypes (proliferation, invasion/EMT) and glutamine metabolism by sponging miR-330-3p to upregulate the glutamine transporter SLC1A5, and its knockdown suppresses xenograft tumor growth. Clinically, higher circ_0000518 expression is associated with worse survival and shows moderate diagnostic value (AUC 0.760)."	0.868
35876041	Clinical and translational medicine	2022	Circular RNA circ-TNPO3 inhibits clear cell renal cell carcinoma metastasis by binding to IGF2BP2 and destabilizing SERPINH1 mRNA.	hsa_circ_0001741	circ_TNPO3 / circ_transportin_3 (TNPO3)	hsa_circ_TNPO3	TNPO3	clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	down-regulated	RT-qPCR; Microarray	"circ-TNPO3 is downregulated in ccRCC and acts as a tumor suppressor by inhibiting ccRCC cell proliferation, migration and metastasis. It binds IGF2BP2 and reduces SERPINH1 mRNA stability, thereby downregulating SERPINH1 and the downstream SERPINH1_SNAIL/SLUG EMT-related axis."	0.8826
35879346	Experimental & molecular medicine	2022	"Circular RNA ROCK1, a novel circRNA, suppresses osteosarcoma proliferation and migration via altering the miR-532-5p/PTEN axis."	hsa_circ_0108024	circROCK1	hsa_circ_ROCK1	ROCK1	osteosarcoma / OS	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; ISH	"circROCK1-E3/E4 (hsa_circ_0108024), derived from ROCK1 exons 3_4, is down-regulated in osteosarcoma and functions as a tumor suppressor. It mainly localizes to the cytoplasm and inhibits proliferation, migration/invasion, tumor growth and lung metastasis by sponging miR-532-5p to increase PTEN; its biogenesis is partially promoted by QKI."	0.8711
35887031	International journal of molecular sciences	2022	Profile of TREM2-Derived circRNA and mRNA Variants in the Entorhinal Cortex of Alzheimer's Disease Patients.		circTREM2_1	hsa_circ_TREM2	TREM2	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR	"This study identifies a TREM2-derived circRNA, circTREM2_1, in human entorhinal cortex and microglial HMC3 cells. circTREM2_1 shows increased expression in AD versus controls by RT-qPCR and its expression negatively correlates with Abeta deposit area in AD cases. Predicted miRNA binding suggests a potential miRNA-sponge/ceRNA-related role, but functional mechanisms remain unvalidated."	0.5841
35891711	Regenerative therapy	2022	Circ_0018168 inhibits the proliferation and osteogenic differentiation of fibroblasts in ankylosing spondylitis via regulating miR-330-3p/DKK1 axis.	hsa_circ_0018168	circ_0018168 / circ_00018168	hsa_circ_PARD3	PARD3	ankylosing spondylitis / AS	MONDO:0005306	ankylosing spondylitis	down-regulated	RT-qPCR	"circ_0018168 is down-regulated in AS hip capsule specimens. Its overexpression suppresses AS fibroblast proliferation, induces G0/G1 arrest, and inhibits osteogenic differentiation by sponging miR-330-3p to increase DKK1 expression."	0.8455
35894157	The Kaohsiung journal of medical sciences	2022	Circ-NCX1 inhibits LPS-induced chondrocyte apoptosis by regulating the miR-133a/SIRT1 axis.		Circ-NCX1 / circNCX1	hsa_circ_NCX1	NCX1	Osteoarthritis / OA	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR	"In an LPS-induced in vitro osteoarthritis cell model (SW1353), circNCX1 is down-regulated, and its overexpression promotes viability/proliferation while inhibiting apoptosis. Mechanistically, circNCX1 sponges miR-133a to restore Sirt1 and activate PI3K/AKT signaling, thereby reducing pro-apoptotic markers (e.g., Bax, cleaved caspase-3)."	0.5301
35896371	Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia	2022	Hsa_circ_0079530/AQP4 Axis Is Related to Non-Small Cell Lung Cancer Development and Radiosensitivity.	hsa_circ_0079530	circ_0079530	hsa_circ_Twist1	Twist1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"This study reports that hsa_circ_0079530 (circ_0079530), derived from Twist1, is up-regulated in NSCLC tissues and especially in radioresistant samples. Functionally, circ_0079530 promotes NSCLC cell proliferation, migration/invasion and tumor growth, and decreases radiosensitivity. Mechanistically, it sponges miR-409-3p to upregulate AQP4, forming a circ_0079530/miR-409-3p/AQP4 axis that drives malignancy and radioresistance."	0.7979
35897048	European journal of medical research	2022	CircWDR26 regulates endometrial carcinoma progression via miR-212-3p-mediated typing genes MSH2.		circWDR26	hsa_circ_WDR26	WDR26	endometrial carcinoma	MONDO:0002447	endometrial carcinoma	up-regulated	RT-qPCR	"circWDR26 is up-regulated in endometrial carcinoma and promotes malignant phenotypes (proliferation, migration/invasion, tumor growth) while inhibiting apoptosis. It functions mainly by sponging miR-212-3p, thereby increasing MSH2 expression through the miR-212-3p/MSH2 axis."	0.7132
35902921	Cancer cell international	2022	"CircPDSS1 promotes the proliferation, invasion, migration, and EMT of breast cancer cell via regulating miR-320c/CKAP5 axis."		circPDSS1	hsa_circ_PDSS1	PDSS1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circPDSS1 is up-regulated in breast cancer cell lines and acts as an oncogenic circRNA. It mainly localizes to the cytoplasm and promotes proliferation, invasion, migration, and EMT (and inhibits apoptosis) via a ceRNA mechanism by sponging miR-320c to upregulate CKAP5."	0.7923
35902926	Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale	2022	Circ_0000144 acts as a miR-1178-3p decoy to promote cell malignancy and angiogenesis by increasing YWHAH expression in papillary thyroid cancer.	hsa_circ_0000144	Circ_0000144	hsa_circ_SLAMF6	SLAMF6	papillary thyroid cancer / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circ_0000144 is up-regulated in papillary thyroid cancer tissues/cells and promotes malignant phenotypes and angiogenesis. It functions as a ceRNA by sponging miR-1178-3p, thereby increasing YWHAH expression and enhancing tumor growth in vitro and in a xenograft model."	0.6919
35904173	Molecular medicine reports	2022	Knockdown of hsa_circ_0005699 attenuates inflammation and apoptosis induced by ox-LDL in human umbilical vein endothelial cells through regulation of the miR-450b-5p/NFKB1 axis.	hsa_circ_0005699	circ_0005699			atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"In an ox-LDL-induced atherosclerosis endothelial-injury model, circ_0005699 is up-regulated and promotes inflammatory cytokine production and apoptosis in HUVECs. Silencing circ_0005699 alleviates injury by sponging miR-450b-5p and reducing NFKB1 expression (circ_0005699/miR-450b-5p/NFKB1 axis)."	0.6578
35908770	Journal of clinical laboratory analysis	2022	Hsa_circ_0129047 regulates the miR-375/ACVRL1 axis to attenuate the progression of lung adenocarcinoma.	hsa_circ_0129047	circ_0129047			lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR	"hsa_circ_0129047 is down-regulated in LUAD tissues and cell lines and acts as a tumor suppressor. It primarily localizes to the cytoplasm and inhibits LUAD cell viability and migration while promoting apoptosis, and it suppresses xenograft tumor growth. Mechanistically, it sponges miR-375 to de-repress ACVRL1, forming the hsa_circ_0129047/miR-375/ACVRL1 axis."	0.7785
35909488	BioMed research international	2022	hsa_circ_0084811 Regulates Cell Proliferation and Apoptosis in Retinoblastoma through miR-18a-5p/miR-18b-5p/E2F5 Axis.	hsa_circ_0084811	circ_0084811	hsa_circ_E2F5	E2F5	Retinoblastoma / RB	MONDO:0008380	retinoblastoma	up-regulated	RT-qPCR	"circ_0084811 is up-regulated in retinoblastoma cell lines and promotes proliferation while inhibiting apoptosis. Mechanistically, H3K27ac/CBP-associated promoter acetylation increases circ_0084811 expression, and circ_0084811 functions as a ceRNA by sponging miR-18a-5p and miR-18b-5p to upregulate E2F5."	0.813
35909542	Frontiers in endocrinology	2022	The Construction and Analysis of Infiltrating Immune Cell and ceRNA Networks in Diabetic Foot Ulcer.	hsa_circ_0049271				Diabetic foot ulcer / DFU	MONDO:0005015	diabetes mellitus	dysregulated	Microarray	"hsa-circ-0049271 was identified from GEO circRNA microarray as a DFU-associated circRNA and highlighted by ROC analysis as a potential discriminator of DFU vs controls. The study proposes a ceRNA axis hsa-circ-0049271_hsa-miR-24_3p_JUNB potentially involved in DFU angiogenesis/infectious inflammation, but lacks experimental wet-lab validation."	0.348
35909542	Frontiers in endocrinology	2022	The Construction and Analysis of Infiltrating Immune Cell and ceRNA Networks in Diabetic Foot Ulcer.	hsa_circ_0074559				Diabetic foot ulcer / DFU	MONDO:0005015	diabetes mellitus	dysregulated	Microarray	"hsa-circ-0074559 was identified from GEO circRNA microarray as a DFU-associated circRNA and highlighted by ROC analysis as a potential discriminator of DFU vs controls. The study links it within a predicted ceRNA network, associating it with hsa-miR-24_3p/hsa-miR-214_3p and downstream JUNB/BLMH, without wet-lab experimental validation."	0.348
35909586	Contrast media & molecular imaging	2022	Effects of circFOXO3 on the Proliferation and Invasion of Liver Cancer Cells by Regulating PI3K/Akt Pathway.		circFOXO3	hsa_circ_FOXO3	FOXO3	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"circFOXO3 is down-regulated in hepatocellular carcinoma cell lines compared with normal hepatocytes. Forced overexpression of circFOXO3 in HuH-7 cells suppresses viability/proliferation, invasion and migration, and increases apoptosis, at least partly by inhibiting PI3K/Akt signaling (reduced p-PI3K and p-Akt)."	0.5434
35915245	Cancer gene therapy	2022	Targeting the androgen receptor to enhance NK cell killing efficacy in bladder cancer by modulating ADAR2/circ_0001005/PD-L1 signaling.	hsa_circ_0001005	circ_0001005 / circASB3	hsa_circ_ASB3	ASB3	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"In bladder cancer cells, circ_0001005 (from ASB3) is upregulated by AR via ADAR2 and functions as a ceRNA that sponges miR-200a-3p, increasing PD-L1 expression. This reduces NK cell-mediated tumor killing and promotes immune escape; targeting this axis improves antitumor efficacy in a xenograft model."	0.74
35915455	Biomedical engineering online	2022	Screening differential circular RNAs expression profiles in Vulvar Lichen Sclerosus.	hsa_circ_0000211				Vulvar lichen sclerosus / VLS	MONDO:0006491	vulvar lichen sclerosus	up-regulated	RNA-seq	"hsa_circ_0000211 is reported as significantly up-regulated in vulvar lichen sclerosus tissues versus controls. The study bioinformatically predicts an interaction between hsa_circ_0000211 and miR-224-5p, suggesting a potential miRNA-sponge/ceRNA-related role in VLS pathogenesis without experimental validation."	0.1768
35915455	Biomedical engineering online	2022	Screening differential circular RNAs expression profiles in Vulvar Lichen Sclerosus.	hsa_circ_0001789				Vulvar lichen sclerosus / VLS	MONDO:0006491	vulvar lichen sclerosus	up-regulated	RNA-seq	hsa_circ_0001789 is identified as significantly up-regulated in VLS tissues compared with healthy vulvar skin by RNA-seq. No circRNA-specific downstream mechanism or clinical association is reported for this circRNA in the study.	0.1768
35915455	Biomedical engineering online	2022	Screening differential circular RNAs expression profiles in Vulvar Lichen Sclerosus.	hsa_circ_0005729				Vulvar lichen sclerosus / VLS	MONDO:0006491	vulvar lichen sclerosus	up-regulated	RNA-seq	hsa_circ_0005729 is identified as significantly up-regulated in VLS tissues compared with healthy vulvar skin by RNA-seq. The paper does not report a specific downstream miRNA/mRNA mechanism or clinical significance for this circRNA.	0.1768
35915455	Biomedical engineering online	2022	Screening differential circular RNAs expression profiles in Vulvar Lichen Sclerosus.	hsa_circ_0000839				Vulvar lichen sclerosus / VLS	MONDO:0006491	vulvar lichen sclerosus	up-regulated	RNA-seq	"hsa_circ_0000839 is significantly up-regulated in VLS tissues. The study predicts that hsa_circ_0000839 may interact with miR-221-5p, implying a possible miRNA-sponge/ceRNA-related role in VLS, but this interaction is only computationally predicted."	0.1768
35915455	Biomedical engineering online	2022	Screening differential circular RNAs expression profiles in Vulvar Lichen Sclerosus.	hsa_circ_0000344				Vulvar lichen sclerosus / VLS	MONDO:0006491	vulvar lichen sclerosus	up-regulated	RNA-seq	"hsa_circ_0000344 is significantly up-regulated in VLS tissues. The study predicts an interaction with miR-196a-3p, suggesting a possible miRNA-related regulatory role in VLS, but this is based on computational prediction only."	0.1768
35915455	Biomedical engineering online	2022	Screening differential circular RNAs expression profiles in Vulvar Lichen Sclerosus.	hsa_circ_0002472				Vulvar lichen sclerosus / VLS	MONDO:0006491	vulvar lichen sclerosus	down-regulated	RNA-seq	hsa_circ_0002472 is identified as significantly down-regulated in VLS tissues compared with healthy vulvar skin by RNA-seq. No circRNA-specific molecular mechanism or clinical significance is provided for this circRNA.	0.1768
35915455	Biomedical engineering online	2022	Screening differential circular RNAs expression profiles in Vulvar Lichen Sclerosus.	hsa_circ_0008059				Vulvar lichen sclerosus / VLS	MONDO:0006491	vulvar lichen sclerosus	down-regulated	RNA-seq	hsa_circ_0008059 is identified as significantly down-regulated in VLS tissues compared with healthy vulvar skin by RNA-seq. The study provides no specific mechanistic or clinical characterization for this circRNA.	0.1768
35915455	Biomedical engineering online	2022	Screening differential circular RNAs expression profiles in Vulvar Lichen Sclerosus.	hsa_circ_0004440				Vulvar lichen sclerosus / VLS	MONDO:0006491	vulvar lichen sclerosus	down-regulated	RNA-seq	hsa_circ_0004440 is identified as significantly down-regulated in VLS tissues compared with healthy vulvar skin by RNA-seq. The study does not provide a specific interaction/mechanism for this circRNA.	0.1768
35915455	Biomedical engineering online	2022	Screening differential circular RNAs expression profiles in Vulvar Lichen Sclerosus.	hsa_circ_0109021				Vulvar lichen sclerosus / VLS	MONDO:0006491	vulvar lichen sclerosus	down-regulated	RNA-seq	"hsa_circ_0109021 is reported among significantly down-regulated circRNAs in VLS tissues; another table lists a similar ID as has_circ_0009021 as down-regulated, indicating potential naming inconsistency. No specific molecular mechanism or clinical relevance is described for this circRNA."	0.1768
35915455	Biomedical engineering online	2022	Screening differential circular RNAs expression profiles in Vulvar Lichen Sclerosus.	hsa_circ_0001742				Vulvar lichen sclerosus / VLS	MONDO:0006491	vulvar lichen sclerosus	down-regulated	RNA-seq	"hsa_circ_0001742 is significantly down-regulated in VLS tissues. The study predicts a circRNA_miRNA interaction between hsa_circ_0001742 and miR-133a-5p, suggesting a possible miRNA-related regulatory role in VLS, based on computational prediction."	0.1768
35917658	"Clinics (Sao Paulo, Brazil)"	2022	Circular RNA hsa_circ_0000317 inhibits non-small cell lung cancer progression through regulating microRNA-494-3p/phosphatase and tensin homolog deleted on chromosome 10 axis.	hsa_circ_0000317	circ_0000317			Non-Small Cell Lung Cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0000317 (circ_0000317) is down-regulated in NSCLC tissues and cell lines and acts as a tumor suppressor by inhibiting NSCLC cell proliferation, migration, and invasion. Mechanistically, it functions as a ceRNA that sponges miR-494-3p, thereby up-regulating PTEN and inhibiting PI3K/AKT pathway activation."	0.7589
35918398	Molecular psychiatry	2022	"A novel circular RNA, circIgfbp2, links neural plasticity and anxiety through targeting mitochondrial dysfunction and oxidative stress-induced synapse dysfunction after traumatic brain injury."	mmu_circ_0008937	circIgfbp2	mmu_circ_Igfbp2	Igfbp2	traumatic brain injury / TBI	MONDO:0858950	traumatic brain injury	up-regulated	RT-qPCR; RNA-seq	"In mouse TBI and oxidative stress-injured neuronal cells, circIgfbp2 is up-regulated and promotes anxiety-like behaviors/sleep disturbance and synaptic dysfunction. It functions mainly as a ceRNA by sponging miR-370-3p to increase BACH1 (and affect HO-1), thereby aggravating mitochondrial dysfunction and oxidative stress; knockdown is protective."	0.7884
35918398	Molecular psychiatry	2022	"A novel circular RNA, circIgfbp2, links neural plasticity and anxiety through targeting mitochondrial dysfunction and oxidative stress-induced synapse dysfunction after traumatic brain injury."	hsa_circ_0058195		hsa_circ_IGFBP2	IGFBP2	traumatic brain injury / TBI	MONDO:0858950	traumatic brain injury	up-regulated	RT-qPCR	hsa_circ_0058195 is up-regulated in serum (and reported in cerebral cortex specimens) of acute TBI patients and is positively associated with post-traumatic anxiety severity (SAS). Serum levels show diagnostic potential for anxiety after TBI based on ROC analysis.	0.4758
35918733	Journal of translational medicine	2022	Exosomes derived from myeloid-derived suppressor cells facilitate castration-resistant prostate cancer progression via S100A9/circMID1/miR-506-3p/MID1.	hsa_circ_0007718	circMID1	hsa_circ_MID1	MID1	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	"circMID1 (hsa_circ_0007718), derived from MID1, is up-regulated in prostate cancer and further elevated in CRPC and in PCa cells treated with MDSC-derived exosomes. It promotes proliferation, migration, invasion, and xenograft growth by sponging miR-506-3p to increase MID1 expression, forming a S100A9/circMID1/miR-506-3p/MID1 regulatory axis."	0.8162
35922747	BMC genomics	2022	Circular RNA expression profiles and CircSnd1-miR-135b/c-foxl2 axis analysis in gonadal differentiation of protogynous hermaphroditic ricefield eel Monopterus albus.		Novel_circ_0001738 / circSnd1	mal_circ_Snd1	Snd1	sex change / sex reversal / gonadal differentiation	MONDO:0002134	physiological sexual disorder	down-regulated	RT-qPCR; RNA-seq	"In ricefield eel gonads, circSnd1 (novel_circ_0001738) is down-regulated during sex change and functions as a ceRNA by sponging mal-miR-135b/c, thereby modulating foxl2 expression."	0.7322
35924235	Frontiers in immunology	2022	Integrated analysis of the functions and clinical implications of exosome circRNAs in colorectal cancer.	hsa_circ_0023233				colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0023233 is up-regulated in serum exosomes from CRC patients and is part of a 6-exosomal circRNA diagnostic model with moderate AUC in training and validation datasets.	0.5047
35924235	Frontiers in immunology	2022	Integrated analysis of the functions and clinical implications of exosome circRNAs in colorectal cancer.	hsa_circ_0001411				colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0001411 is up-regulated in serum exosomes from CRC patients and contributes to a 6-exosomal circRNA diagnostic model validated in external GEO cohorts.	0.5047
35924235	Frontiers in immunology	2022	Integrated analysis of the functions and clinical implications of exosome circRNAs in colorectal cancer.	hsa_circ_0019120				colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0019120 is up-regulated in CRC serum exosomes and is one component of a six-circRNA exosomal diagnostic signature verified by RT-qPCR in an independent clinical serum set.	0.5047
35924235	Frontiers in immunology	2022	Integrated analysis of the functions and clinical implications of exosome circRNAs in colorectal cancer.	hsa_circ_0091103				colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0091103 is down-regulated in CRC serum exosomes and is one feature in the validated 6-exosomal circRNA diagnostic model.	0.5047
35924235	Frontiers in immunology	2022	Integrated analysis of the functions and clinical implications of exosome circRNAs in colorectal cancer.	hsa_circ_0063681				colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0063681 is down-regulated in CRC serum exosomes and is part of a multi-circRNA diagnostic model validated by ROC analysis and RT-qPCR in clinical serum samples.	0.5047
35924235	Frontiers in immunology	2022	Integrated analysis of the functions and clinical implications of exosome circRNAs in colorectal cancer.	hsa_circ_0050334				colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RNA-seq	"hsa_circ_0050334 is an exosomal circRNA implicated via bioinformatics in a CRC survival-related ceRNA subnetwork (hsa_circ_0050334_hsa_miR_182_5p_RGS2), proposed to promote CRC progression and relate to immune infiltration (not experimentally validated for circRNA expression in this paper¡¯s clinical qPCR section)."	0.348
35927233	Cell death discovery	2022	Circular RNA circPOSTN promotes neovascularization by regulating miR-219a-2-3p/STC1 axis and stimulating the secretion of VEGFA in glioblastoma.		circPOSTN	hsa_circ_POSTN	POSTN	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR	"circPOSTN is upregulated in glioblastoma tissues and cell lines and functions as an oncogenic circRNA. It mainly localizes to the cytoplasm and promotes GBM proliferation, migration, and neovascularization by sponging miR-219a-2-3p to upregulate STC1, thereby increasing VEGFA secretion and enhancing angiogenic activity."	0.8037
35928926	Disease markers	2022	circRPPH1_025 Overexpression Promotes Migration and Invasion of Glioblastoma Multiforme.	hsa_circ_0000512	circ_0000512 / circRPPH1_025	hsa_circ_RPPH1	RPPH1	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR	"circ_0000512 (circRPPH1_025) is up-regulated in GBM cell lines and promotes U87 cell proliferation, migration, invasion and EMT. Its overexpression decreases E-cadherin and increases N-cadherin and Snail, suggesting an EMT-promoting role."	0.5301
35931993	BMC cancer	2022	High-throughput circular RNA sequencing reveals the profiles of circular RNA in non-cirrhotic hepatocellular carcinoma.	hsa_circ_0002473	circ0002473	hsa_circ_DNAJC3	DNAJC3	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0002473 is up-regulated in HCC tissues and promotes HCC cell proliferation and migration, as its knockdown inhibits these phenotypes in SK-Hep1 cells. A circRNA-miRNA-mRNA (ceRNA) regulatory mechanism was computationally predicted."	0.7244
35931993	BMC cancer	2022	High-throughput circular RNA sequencing reveals the profiles of circular RNA in non-cirrhotic hepatocellular carcinoma.		novel_circ_0013894 / circ0013894	hsa_circ_SPATA6	SPATA6	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"novel_circ_0013894 is up-regulated in HCC tissues and promotes HCC cell proliferation and migration, as knockdown inhibits both phenotypes in SK-Hep1 cells. A circRNA-miRNA-mRNA (ceRNA) network was computationally predicted for this circRNA group."	0.7244
35931993	BMC cancer	2022	High-throughput circular RNA sequencing reveals the profiles of circular RNA in non-cirrhotic hepatocellular carcinoma.		novel_circ_0015002 / circ0015002	hsa_circ_LBP	LBP	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"novel_circ_0015002 is up-regulated in HCC tissues and promotes HCC cell proliferation and migration, as knockdown inhibits both phenotypes in SK-Hep1 cells. A circRNA-miRNA-mRNA (ceRNA) network was computationally predicted for this circRNA group."	0.7244
35931993	BMC cancer	2022	High-throughput circular RNA sequencing reveals the profiles of circular RNA in non-cirrhotic hepatocellular carcinoma.	hsa_circ_0003823	circ0003823	hsa_circ_CEP70	CEP70	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0003823 is down-regulated in non-cirrhotic HCC and acts as a tumor-suppressive circRNA in vitro, since its knockdown promotes SK-Hep1 cell growth and migration. Candidate miRNAs were predicted within a circRNA-miRNA-mRNA network."	0.7244
35933226	International dental journal	2023	Circ_0099630 Participates in SPRY1-Mediated Repression in Periodontitis.	hsa_circ_0099630	circ_0099630	hsa_circ_RMST	RMST	periodontitis	MONDO:0005076	periodontitis	up-regulated	RT-qPCR	"In periodontitis-derived iPDLCs, circ_0099630 is up-regulated and mainly localized in the cytoplasm. It inhibits iPDLC proliferation, cell-cycle progression, and osteogenic differentiation by sponging miR-212-5p, thereby relieving miR-212-5p-mediated repression of SPRY1."	0.7507
35942560	The Journal of international medical research	2022	Bioinformatics analysis of mRNA profiles and identification of microRNA-mRNA network in CD4+ T cells in seasonal allergic rhinitis.	hsa_circ_0095386				seasonal allergic rhinitis / SAR	MONDO:0005324	seasonal allergic rhinitis	unknown	Microarray	Identified by CircBank-based bioinformatics screening as a candidate circRNA potentially regulating hsa-miR-29b-3p in seasonal allergic rhinitis. No experimental validation or expression direction for this circRNA was reported.	0.1768
35942560	The Journal of international medical research	2022	Bioinformatics analysis of mRNA profiles and identification of microRNA-mRNA network in CD4+ T cells in seasonal allergic rhinitis.	hsa_circ_0044548				seasonal allergic rhinitis / SAR	MONDO:0005324	seasonal allergic rhinitis	unknown	Microarray	Identified by CircBank-based bioinformatics screening as a candidate circRNA potentially regulating hsa-miR-29b-3p in seasonal allergic rhinitis. No experimental validation or expression direction for this circRNA was reported.	0.1768
35942560	The Journal of international medical research	2022	Bioinformatics analysis of mRNA profiles and identification of microRNA-mRNA network in CD4+ T cells in seasonal allergic rhinitis.	hsa_circ_0081146				seasonal allergic rhinitis / SAR	MONDO:0005324	seasonal allergic rhinitis	unknown	Microarray	Identified by CircBank-based bioinformatics screening as a candidate circRNA potentially regulating hsa-miR-29b-3p in seasonal allergic rhinitis. No experimental validation or expression direction for this circRNA was reported.	0.1768
35942560	The Journal of international medical research	2022	Bioinformatics analysis of mRNA profiles and identification of microRNA-mRNA network in CD4+ T cells in seasonal allergic rhinitis.	hsa_circ_0057377				seasonal allergic rhinitis / SAR	MONDO:0005324	seasonal allergic rhinitis	unknown	Microarray	Identified by CircBank-based bioinformatics screening as a candidate circRNA potentially regulating hsa-miR-29b-3p in seasonal allergic rhinitis. No experimental validation or expression direction for this circRNA was reported.	0.1768
35942560	The Journal of international medical research	2022	Bioinformatics analysis of mRNA profiles and identification of microRNA-mRNA network in CD4+ T cells in seasonal allergic rhinitis.	hsa_circ_0057450				seasonal allergic rhinitis / SAR	MONDO:0005324	seasonal allergic rhinitis	unknown	Microarray	Identified by CircBank-based bioinformatics screening as a candidate circRNA potentially regulating hsa-miR-29b-3p in seasonal allergic rhinitis. No experimental validation or expression direction for this circRNA was reported.	0.1768
35942560	The Journal of international medical research	2022	Bioinformatics analysis of mRNA profiles and identification of microRNA-mRNA network in CD4+ T cells in seasonal allergic rhinitis.	hsa_circ_0056444				seasonal allergic rhinitis / SAR	MONDO:0005324	seasonal allergic rhinitis	unknown	Microarray	Identified by CircBank-based bioinformatics screening as a candidate circRNA potentially regulating hsa-miR-29b-3p in seasonal allergic rhinitis. No experimental validation or expression direction for this circRNA was reported.	0.1768
35943670	Biochemical genetics	2023	High Expression of circ_0001821 Promoted Colorectal Cancer Progression Through miR-600/ISOC1 Axis.	hsa_circ_0001821	circ_0001821			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0001821 is up-regulated in colorectal cancer tissues and cell lines and promotes malignant phenotypes (proliferation, migration/invasion, glycolysis) while suppressing apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-600 to increase ISOC1 expression, and its knockdown suppresses tumor growth in a xenograft model."	0.7371
35945192	Cell death & disease	2022	CircKPNB1 mediates a positive feedback loop and promotes the malignant phenotypes of GSCs via TNF-alpha/NF-kappaB signaling.	hsa_circ_0004796	circKPNB1	hsa_circ_KPNB1	KPNB1	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; RNA-seq	"circKPNB1 (hsa_circ_0004796) is upregulated in glioma/GBM and promotes GSC malignant phenotypes (viability, proliferation, invasion, neurosphere formation, stemness) and in vivo tumor growth. Mechanistically, it binds SPI1 to enhance SPI1 protein stability and nuclear translocation, leading to TNF-alpha_mediated NF-kappaB activation; SPI1 upregulates DGCR8, which binds and stabilizes circKPNB1, forming a positive feedback loop. High circKPNB1 expression correlates with poor patient survival and shows diagnostic potential by ROC analysis."	0.8969
35945200	Cell death & disease	2022	Circular RNA circNFKB1 promotes osteoarthritis progression through interacting with ENO1 and sustaining NF-kappaB signaling.	hsa_circ_0008012	circNFKB1	hsa_circ_NFKB1	NFKB1	osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; ISH; RNA-seq	"circNFKB1 (has_circ_0008012), derived from NFKB1 exons 2_5 and present in both nucleus and cytoplasm, is upregulated in inflamed chondrocytes and osteoarthritic cartilage. It promotes ECM catabolism and OA progression by binding ENO1, enhancing parental gene NFKB1 expression, and sustaining NF-kappaB signaling activation."	0.8193
35949038	Journal of clinical laboratory analysis	2022	Hsa_circ_0045932 regulates the progression of colorectal cancer by regulating HK2 through sponging miR-873-5p.	hsa_circ_0045932				colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"hsa_circ_0045932 is up-regulated in colorectal cancer and promotes malignant phenotypes (proliferation, migration/invasion, and glycolysis) and tumor growth. Mechanistically, it functions as a ceRNA by sponging miR-873-5p, thereby de-repressing HK2."	0.7789
35950768	Chinese medical journal	2022	hsa_circ_0056856 in the serum serves as a potential novel biomarker for disease activity in psoriasis.	hsa_circ_0056856				psoriasis	MONDO:0005083	psoriasis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0056856 is up-regulated in psoriasis patient serum (and PBMCs) and shows diagnostic potential (ROC AUC 0.853). Its serum level correlates positively with PASI and decreases after treatment, supporting use as a disease activity/therapy response biomarker. Bioinformatic predictions suggest it may act via a ceRNA network involving several candidate miRNAs and downstream target mRNAs linked to histone modification-related processes."	0.5047
35951762	Interactive cardiovascular and thoracic surgery	2022	Knockdown of circ_0002194 protects against oxidized low-density lipoprotein-induced cell damage via the regulation of the miR-637/PACS2 axis in human vascular endothelial cells.	hsa_circ_0002194	circ_0002194	hsa_circ_RELL1	RELL1	atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"circ_0002194 is upregulated in ox-LDL-treated human endothelial cells and aggravates endothelial dysfunction. It functions as a sponge for miR-637, relieving miR-637-mediated repression of PACS2, thereby promoting apoptosis and oxidative injury and impairing angiogenic capacity."	0.7394
35954204	Cells	2022	Whole Transcriptome Analysis Identifies Platycodin D-Mediated RNA Regulatory Network in Non-Small-Cell Lung Cancer.	hsa_circ_0001326	hsa_circRNA_0001326	hsa_circ_PHLDB2	PHLDB2	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circRNA_0001326 (from host gene PHLDB2) is down-regulated in serum of NSCLC patients versus healthy volunteers. In PD-treated A549 cells, its expression increases, indicating it is PD-responsive and may be involved in PD-associated regulatory changes in NSCLC cells."	0.5841
35954204	Cells	2022	Whole Transcriptome Analysis Identifies Platycodin D-Mediated RNA Regulatory Network in Non-Small-Cell Lung Cancer.	hsa_circ_0001946	hsa_circRNA_0001946	hsa_circ_CDR1	CDR1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0001946 (from host gene CDR1) is down-regulated in serum of NSCLC patients versus healthy volunteers. It is PD-responsive in A549 cells (down-regulated after PD treatment) and was included as a key circRNA in the PD-related co-expression/regulatory network analysis.	0.5841
35954204	Cells	2022	Whole Transcriptome Analysis Identifies Platycodin D-Mediated RNA Regulatory Network in Non-Small-Cell Lung Cancer.	hsa_circ_0005870	hsa_circRNA_0005870	hsa_circ_SETD2	SETD2	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RNA-seq	"hsa_circ_0005870 (from host gene SETD2) is up-regulated in serum of NSCLC patients versus healthy volunteers and is identified as a PD-responsive circRNA from whole-transcriptome profiling. However, this study did not report a significant RT-qPCR expression change for hsa_circ_0005870 in PD-treated A549 cells."	0.5297
35954204	Cells	2022	Whole Transcriptome Analysis Identifies Platycodin D-Mediated RNA Regulatory Network in Non-Small-Cell Lung Cancer.	hsa_circ_0006702	hsa_circRNA_0006702	hsa_circ_IARS	IARS	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0006702 (from host gene IARS) is up-regulated in serum of NSCLC patients versus healthy volunteers. In PD-treated A549 cells it is down-regulated by RT-qPCR, indicating it is PD-responsive and potentially involved in PD-mediated RNA regulatory changes."	0.5841
35954204	Cells	2022	Whole Transcriptome Analysis Identifies Platycodin D-Mediated RNA Regulatory Network in Non-Small-Cell Lung Cancer.	hsa_circ_0006990	hsa_circRNA_0006990	hsa_circ_VAPA	VAPA	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RNA-seq	hsa_circ_0006990 (from host gene VAPA) is up-regulated in serum of NSCLC patients versus healthy volunteers and is highlighted as a key circRNA in the TCGA/GEO-derived circRNA network analysis. This study did not report a significant RT-qPCR expression change for hsa_circ_0006990 in PD-treated A549 cells.	0.5297
35958928	Evidence-based complementary and alternative medicine : eCAM	2022	CircAGFG1 Promotes Osteosarcoma Progression and Stemness by Competing with miR-302a-3p to Upregulate the Expression of LATS2.		circAGFG1	hsa_circ_AGFG1	AGFG1	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circAGFG1 is up-regulated in osteosarcoma cell lines and promotes proliferation, invasion/migration, metastasis, and stemness. Mechanistically, it functions as a ceRNA by binding miR-302a-3p to upregulate LATS2, supporting osteosarcoma progression."	0.5997
35962012	Scientific reports	2022	The diagnostic value of has_circ_0006423 in non-small cell lung cancer and its role as a tumor suppressor gene that sponges miR-492.	hsa_circ_0006423	hsa_circ_0006423	hsa_circ_BCAR3	BCAR3	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"hsa_circ_0006423 (BCAR3-derived) is down-regulated in NSCLC plasma, tumors, and NSCLC cell lines and shows diagnostic potential by ROC analysis. Functionally, it acts as a cytoplasmic sponge of miR-492 and suppresses NSCLC cell proliferation, migration, and invasion while promoting apoptosis and inducing G0/G1 cell-cycle arrest."	0.8162
35962061	Scientific reports	2022	The circRNA circADAMTS6 promotes progression of ESCC and correlates with prognosis.	hsa_circ_0072688	circADAMTS6	hsa_circ_ADAMTS6	ADAMTS6	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; ISH	"circADAMTS6 (hsa_circ_0072688) is up-regulated in ESCC tissues/cells and its high expression predicts shorter overall survival. Functionally, circADAMTS6 promotes ESCC proliferation, migration, invasion and xenograft tumor growth, at least in part by positively regulating AGR2 and activating Hippo/YAP signaling (increased YAP and decreased pYAP)."	0.801
35963645	Aging	2022	Targeting circRNA-MAP4K2 for the treatment of diabetes-induced retinal vascular dysfunction.		circular RNA-MAP4K2 (cMAP4K2) / circRNA-MAP4K2	hsa_circ_MAP4K2	MAP4K2	diabetic retinopathy / DR	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR	"cMAP4K2 is up-regulated under high glucose and in diabetic retinopathy, promotes endothelial angiogenic behaviors and worsens retinal vascular leakage/inflammation. It functions as a ceRNA by sponging miR-377, thereby increasing VEGFA expression; cMAP4K2 levels in vitreous/AH show diagnostic potential for DR."	0.7589
35964136	Stem cell research & therapy	2022	Circular RNA BIRC6 depletion promotes osteogenic differentiation of periodontal ligament stem cells via the miR-543/PTEN/PI3K/AKT/mTOR signaling pathway in the inflammatory microenvironment.		Circular RNA BIRC6 / circBIRC6	hsa_circ_BIRC6	BIRC6	periodontitis	MONDO:0005076	periodontitis	up-regulated	RT-qPCR	circBIRC6 is up-regulated in inflamed PDLSCs and periodontitis tissues and functions as a negative regulator of osteogenic differentiation/mineralization. It sponges miR-543 to modulate PTEN and thereby affects PI3K/AKT/mTOR signaling in the inflammatory microenvironment.	0.7087
35965327	Journal of ovarian research	2022	Circular RNA circ-BNC2 (hsa_circ_0008732) inhibits the progression of ovarian cancer through microRNA-223-3p/ FBXW7 axis.	hsa_circ_0008732	circRNA-BNC2 / circ-BNC2	hsa_circ_BNC2	BNC2	ovarian cancer / OC	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR	"circ-BNC2 (hsa_circ_0008732) is down-regulated in ovarian cancer and functions as a tumor suppressor. It mainly localizes to the cytoplasm and sponges miR-223-3p to increase FBXW7 expression, thereby inhibiting proliferation, migration/invasion, cell-cycle progression, and metastasis."	0.7759
35965793	Annals of translational medicine	2022	Identification of the hsa_circ_0039466/miR-96-5p/FOXO1 regulatory network in hepatocellular carcinoma by whole-transcriptome analysis.	hsa_circ_0039466				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"This study identifies hsa_circ_0039466 as down-regulated in HCC tissues and proposes a ceRNA mechanism in which hsa_circ_0039466 sponges miR-96-5p to facilitate FOXO1 expression, thereby inhibiting tumor progression. The axis is associated with clinical stage and is linked by enrichment analysis to insulin resistance/insulin metabolism-related pathways."	0.4032
35966290	Translational cancer research	2022	CircHIPK2 promotes proliferation of nasopharyngeal carcinoma by down-regulating HIPK2.	hsa_circ_0001756	circHIPK2	hsa_circ_HIPK2	HIPK2	nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; RNA-seq	"circHIPK2 (hsa_circ_0001756), derived from HIPK2, is up-regulated in nasopharyngeal carcinoma tissues and promotes NPC cell proliferation and xenograft tumor growth. Mechanistically, circHIPK2 post-transcriptionally suppresses HIPK2 protein and increases beta-catenin protein levels, supporting an oncogenic circHIPK2/HIPK2 axis."	0.5949
35973363	Redox biology	2022	CircSV2b participates in oxidative stress regulation through miR-5107-5p-Foxk1-Akt1 axis in Parkinson's disease.		mmu-SV2b-0002 / circSV2b	mmu_circ_SV2b	SV2b	Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	down-regulated	RT-qPCR; RNA-seq	"In an MPTP-induced Parkinson¡¯s disease mouse model, circSV2b is down-regulated in SNpc, STR and serum exosomes. circSV2b overexpression is neuroprotective and reduces oxidative stress by sponging miR-5107-5p, thereby increasing Foxk1 and promoting Akt1 transcription, suggesting biomarker and therapeutic potential."	0.7978
35974419	Biomarker research	2022	CircRNA 0009043 suppresses non-small-cell lung cancer development via targeting the miR-148a-3p/DNAJB4 axis.	hsa_circ_0009043	circ_0009043 / circRNA_0009043			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; ISH	"circ_0009043 is down-regulated in NSCLC tissues/cells and acts as a tumor-suppressive circRNA. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-148a-3p, thereby relieving repression of DNAJB4 and inhibiting proliferation while promoting apoptosis and reducing xenograft tumor growth."	0.8426
35974702	Molecular therapy : the journal of the American Society of Gene Therapy	2023	The short inverted repeats-induced circEXOC6B inhibits prostate cancer metastasis by enhancing the binding of RBMS1 and HuR.	hsa_circ_0009043	circEXOC6B	hsa_circ_EXOC6B	EXOC6B	prostate cancer / PCa	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; ISH; RNA-seq; Microarray	"circEXOC6B is down-regulated in prostate cancer and acts as a metastasis suppressor. It functions as a protein scaffold to enhance RBMS1_HuR complex formation, increasing AKAP12 mRNA stability and AKAP12 expression, thereby inhibiting migration, invasion, and lung metastasis."	0.8805
35975639	Gut and liver	2023	circ-LDLRAD3 Knockdown Reduces Cisplatin Chemoresistance and Inhibits the Development of Gastric Cancer with Cisplatin Resistance through miR-588 Enrichment-Mediated SOX5 Inhibition.	hsa_circ_0006988	circ-LDLRAD3	hsa_circ_LDLRAD3	LDLRAD3	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ-LDLRAD3 (hsa_circ_0006988) is up-regulated in cisplatin-resistant gastric cancer tissues/cells and promotes cisplatin chemoresistance, proliferation/survival and invasion. Mechanistically, it acts as a sponge for miR-588 to increase SOX5 expression, and it is enriched in exosomes from DDP-resistant GC cells."	0.7662
35978436	Journal of ovarian research	2022	Differentially expression and function of circular RNAs in ovarian cancer stem cells.		hsa-circRNA000963 	hsa_circ_BCLAF1	BCLAF1	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	Microarray	"hsa-circRNA000963 is up-regulated in ovarian cancer stem cell-like sphere-forming cells (A2780-SP and SKOV3-SP) versus monolayer cells. The study constructed a predicted circRNA_miRNA_mRNA network in which hsa-circRNA000963 may act as a miRNA sponge for five candidate miRNAs, with target enrichment implicating stemness-related pathways (e.g., PI3K-Akt, cell cycle, p53, Wnt)."	0.1768
35979014	Mediators of inflammation	2022	circ-Katnal1 Enhances Inflammatory Pyroptosis in Sepsis-Induced Liver Injury through the miR-31-5p/GSDMD Axis.	mmu_circ_0001432	circ-Katnal1	mmu_circ_Katnal1	Katnal1	sepsis-induced liver injury	MONDO:0005154	liver disorder	up-regulated	RT-qPCR; RNA-seq	"In a CLP-induced murine sepsis liver-injury model, circ-Katnal1 (mmu_circ_0001432, from Katnal1) is up-regulated and promotes inflammatory pyroptosis. Mechanistically, circ-Katnal1 targets miR-31-5p, thereby relieving repression of GSDMD and enhancing pyroptosis-associated inflammatory responses; silencing circ-Katnal1 is protective."	0.6722
35982472	Biomarker research	2022	A circular RNA blood panel that differentiates Alzheimer's disease from other dementia types.	hsa_circ_0077001				Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RNA-seq	"hsa_circ_0077001 is up-regulated in blood of AD patients and is part of a six-circRNA panel that accurately differentiates AD from controls and from other dementia types (VaD, PDD, bvFTD, DLB). No molecular mechanism was experimentally characterized in this study."	0.348
35982472	Biomarker research	2022	A circular RNA blood panel that differentiates Alzheimer's disease from other dementia types.	hsa_circ_0022417				Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RNA-seq	hsa_circ_0022417 is up-regulated in blood of AD patients and contributes to an AD-specific six-circRNA diagnostic panel that differentiates AD from controls and other dementia types. No mechanistic interactions were validated in this work.	0.348
35982472	Biomarker research	2022	A circular RNA blood panel that differentiates Alzheimer's disease from other dementia types.	hsa_circ_0014356				Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RNA-seq	hsa_circ_0014356 is up-regulated in blood of AD patients and is included in an AD-specific six-circRNA panel with strong diagnostic performance for distinguishing AD from controls and other dementias. Mechanistic functions were not determined.	0.348
35982472	Biomarker research	2022	A circular RNA blood panel that differentiates Alzheimer's disease from other dementia types.	hsa_circ_0014353				Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RNA-seq	hsa_circ_0014353 is elevated in blood from AD patients and is part of an AD-specific six-circRNA diagnostic panel validated across independent datasets to distinguish AD from controls and other dementias. The study did not validate downstream targets or mechanisms.	0.348
35982472	Biomarker research	2022	A circular RNA blood panel that differentiates Alzheimer's disease from other dementia types.	hsa_circ_0074533				Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RNA-seq	hsa_circ_0074533 is up-regulated in blood of AD patients and forms part of a six-circRNA panel with high ROC performance for distinguishing AD from controls and other dementia types. The study did not experimentally determine its mechanism.	0.348
35982472	Biomarker research	2022	A circular RNA blood panel that differentiates Alzheimer's disease from other dementia types.	hsa_circ_0089894				Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RNA-seq	hsa_circ_0089894 is down-regulated in blood of AD patients and is the sole decreased member of an AD-specific six-circRNA diagnostic panel that differentiates AD from controls and other dementia types. No mechanistic pathway was established for this circRNA in the study.	0.348
35982735	Oxidative medicine and cellular longevity	2022	Circular RNA hsa_circ_0002360 Promotes Proliferation and Invasion and Inhibits Oxidative Stress in Gastric Cancer by Sponging miR-629-3p and Regulating the PDLIM4 Expression.	hsa_circ_0002360	circ0002360 / circRNA_0002360	hsa_circ_RUNX1	RUNX1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"hsa_circ_0002360 (circ0002360) is up-regulated in gastric cancer cell lines and mainly enriched in the cytoplasm. It promotes proliferation and invasion and suppresses oxidative stress by sponging miR-629-3p, thereby increasing PDLIM4 expression."	0.7437
35982887	International journal of biological sciences	2022	Nitroxoline suppresses metastasis in bladder cancer via EGR1/circNDRG1/miR-520h/smad7/EMT signaling pathway.	hsa_circ_0085656	circNDRG1	hsa_circ_NDRG1	NDRG1	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"circNDRG1 is induced by nitroxoline in bladder cancer cell lines and suppresses migration/metastasis in vitro and in a tail-vein xenograft model. Mechanistically, EGR1 upregulates circNDRG1, which sponges miR-520h to increase smad7 and inhibit EMT."	0.8015
35982888	International journal of biological sciences	2022	Decrease of circARID1A retards glioblastoma invasion by modulating miR-370-3p/ TGFBR2 pathway.	hsa_circ_0008494	circARID1A	hsa_circ_ARID1A	ARID1A	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; ISH; Microarray	"circARID1A is up-regulated in glioblastoma tissues and cell lines and promotes GBM migration/invasion. It acts mainly in the cytoplasm as a miRNA sponge for miR-370-3p, thereby increasing TGFBR2 expression and enhancing invasive phenotypes; knockdown reduces tumor growth in a U87 intracranial xenograft model. circARID1A is enriched in GBM cell-derived exosomes and may serve as a serum biomarker."	0.8609
35986280	Molecular cancer	2022	Circular RNA circFIRRE drives osteosarcoma progression and metastasis through tumorigenic-angiogenic coupling.	hsa_circ_0001944	circFIRRE	hsa_circ_FIRRE	FIRRE	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circFIRRE (hsa_circ_0001944) is upregulated in osteosarcoma tissues and cell lines and promotes tumor growth, migration/invasion, angiogenesis and lung metastasis. Mechanistically, YY1 activates circFIRRE, which sponges miR-486-3p and miR-1225-5p to upregulate LUZP1, contributing to tumorigenic-angiogenic coupling and poor prognosis."	0.8933
35986300	Journal of experimental & clinical cancer research : CR	2022	CircARID1A binds to IGF2BP3 in gastric cancer and promotes cancer proliferation by forming a circARID1A-IGF2BP3-SLC7A5 RNA-protein ternary complex.	hsa_circ_0008494	circARID1A	hsa_circ_ARID1A	ARID1A	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; ISH; RNA-seq	CircARID1A is up-regulated in gastric cancer and mainly localizes to the cytoplasm. It binds IGF2BP3 and SLC7A5 mRNA to form a ternary RNA_protein complex that increases SLC7A5 mRNA stability and promotes GC proliferation through AKT/mTOR signaling.	0.8719
35989496	Journal of clinical laboratory analysis	2022	"Upregulation of hsa_circ_0004812 promotes COVID-19 cytokine storm via hsa-miR-1287-5p/IL6R, RIG-I axis."	hsa_circ_0004812		hsa_circ_NINL	NINL	COVID-19 / coronavirus disease 2019 	MONDO:0100096	COVID-19	up-regulated	RT-qPCR	"hsa_circ_0004812 is up-regulated in PBMCs from COVID-19 patients, especially symptomatic cases. It is proposed to act as a ceRNA that sponges hsa-miR-1287-5p, associated with increased IL6R and RIG-I expression and involvement of JAK/STAT and PI3K/AKT-related inflammatory signaling in COVID-19 cytokine storm."	0.348
35990982	Frontiers in cardiovascular medicine	2022	Construction and analysis of competing endogenous RNA network and patterns of immune infiltration in abdominal aortic aneurysm.	hsa_circ_0002722				abdominal aortic aneurysm / AAA	MONDO:0005350	abdominal aortic aneurysm	dysregulated	RT-qPCR; Microarray	"This study constructed a ceRNA network in abdominal aortic aneurysm and clinically validated that hsa_circ_0002722 is involved in the hsa_circ_0002722_miR-130a/b-3p_PPARG axis, suggesting an association with AAA pathogenesis and inflammatory/SMC-related changes via PPARG regulation."	0.4032
35990982	Frontiers in cardiovascular medicine	2022	Construction and analysis of competing endogenous RNA network and patterns of immune infiltration in abdominal aortic aneurysm.	hsa_circ_0001837				abdominal aortic aneurysm / AAA	MONDO:0005350	abdominal aortic aneurysm	dysregulated	RT-qPCR; Microarray	"The study proposes and clinically supports a ceRNA axis in AAA where hsa_circ_0001837 may regulate FOXO1 through miR-135a/b-5p, potentially influencing AAA-related processes such as apoptosis, inflammation, and SMC functional changes via FOXO1."	0.4032
35990982	Frontiers in cardiovascular medicine	2022	Construction and analysis of competing endogenous RNA network and patterns of immune infiltration in abdominal aortic aneurysm.	hsa_circ_0000941				abdominal aortic aneurysm / AAA	MONDO:0005350	abdominal aortic aneurysm	dysregulated	RT-qPCR; Microarray	"This study indicates that hsa_circ_0000941 participates in a proposed and clinically supported ceRNA axis (hsa_circ_0000941_miR-135a/b-5p_FOXO1) associated with AAA pathogenesis, potentially affecting FOXO1-related processes such as apoptosis, inflammation, and autophagy."	0.4032
35991513	Non-coding RNA research	2022	Circulating ciRS-7 as a potential non-invasive biomarker for epithelial ovarian cancer: An investigative study.		ciRS-7 / cirRS-7	hsa_circ_CDR1	CDR1	epithelial ovarian cancer / EOC	MONDO:0005140	ovarian carcinoma	dysregulated	RT-qPCR	"This study reports that circulating ciRS-7 is aberrantly expressed in EOC plasma (higher preoperatively) and has diagnostic value by ROC analysis. High ciRS-7 levels are associated with lymph node/distant metastasis and worse overall survival, and ciRS-7 is an independent prognostic factor in advanced-stage EOC. Mechanistically, it is proposed to act as a sponge for hsa-miR-7-5p based on predicted binding and an inverse plasma correlation."	0.5339
35992546	Contrast media & molecular imaging	2022	Circular RNA MELK Promotes Chondrocyte Apoptosis and Inhibits Autophagy in Osteoarthritis by Regulating MYD88/NF-kappaB Signaling Axis through MicroRNA-497-5p.	hsa_circ_0009127	circular RNA MELK / circMELK	hsa_circ_MELK	MELK	Osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circMELK is up-regulated in OA cartilage and IL-1beta-stimulated human chondrocytes. It promotes chondrocyte apoptosis, suppresses autophagy, and enhances inflammatory responses by sponging miR-497-5p to upregulate MYD88 and activate NF-kappaB signaling."	0.8278
35992547	Contrast media & molecular imaging	2022	Study on the Mechanism of circRNA-0024103 Reducing Endothelial Cell Injury by Regulating miR-363/MMP-10.	hsa_circ_0024103	circRNA-0024103 / circ-0024103			atherosclerosis / AS	MONDO:0005311	atherosclerosis	unknown	RT-qPCR	"In ox-LDL_treated endothelial cells, circRNA-0024103 promotes proliferation, migration/invasion and tube formation while inhibiting apoptosis. Mechanistically, it sponges miR-363 to upregulate MMP-10 and increase VEGF expression, forming a circRNA-0024103/miR-363/MMP-10 axis relevant to atherosclerosis-related endothelial injury."	0.5312
35992812	Frontiers in oncology	2022	Oncogenic circular RNA circ_0007534 contributes to paclitaxel resistance in endometrial cancer by sponging miR-625 and promoting ZEB2 expression.	hsa_circ_0007534	circ_0007534	hsa_circ_DDX42	DDX42	Endometrial cancer / EC	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR	"circ_0007534 is up-regulated in endometrial cancer and mainly localized in the cytoplasm. It promotes proliferation, invasion, EMT, and paclitaxel resistance by sponging miR-625 and thereby increasing ZEB2 expression, and its high expression is associated with poor prognosis."	0.7846
35993557	Genetics and molecular biology	2022	Circular RNA circENTPD7 suppresses the accumulation of PTEN to promote cell proliferation in non-small cell lung cancer.		circular RNA ENTPD7 / circENTPD7	hsa_circ_ENTPD7	ENTPD7	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circENTPD7 is up-regulated in NSCLC tissues and its high expression is associated with poorer overall survival. Functionally, circENTPD7 promotes NSCLC cell proliferation by reducing PTEN protein accumulation without changing PTEN mRNA, suggesting translational or post-translational regulation of PTEN."	0.6527
35996149	Cancer cell international	2022	Circular RNA circWWC3 augments breast cancer progression through promoting M2 macrophage polarization and tumor immune escape via regulating the expression and secretion of IL-4.	hsa_circ_0001910	circWWC3	hsa_circ_WWC3	WWC3	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; ISH	"In breast cancer, circWWC3 promotes tumor progression by increasing IL-4 expression/secretion from tumor cells, which drives M2-like macrophage polarization and elevates PD-L1 in both TAMs and cancer cells, contributing to immune escape and enhanced migration. High circWWC3 expression in patient tissues correlates with worse OS/DFS."	0.7564
36003513	Frontiers in pharmacology	2022	Identification of circular RNAs in cardiac hypertrophy and cardiac fibrosis.		mmu-Nfkb1_0001	mmu_circ_Nfkb1	Nfkb1	cardiac hypertrophy 	MONDO:0005045	hypertrophic cardiomyopathy	down-regulated	RT-qPCR; RNA-seq	mmu-Nfkb1_0001 was identified by GSEA as a key circRNA involved in TAC-induced cardiac hypertrophy/cardiac fibrosis and was validated by qPCR to be down-regulated at 2 weeks after TAC.	0.5922
36003513	Frontiers in pharmacology	2022	Identification of circular RNAs in cardiac hypertrophy and cardiac fibrosis.		mmu-Smad4_0007	mmu_circ_Smad4	Smad4	cardiac hypertrophy 	MONDO:0005045	hypertrophic cardiomyopathy	unknown	RNA-seq	mmu-Smad4_0007 was identified as a key circRNA associated with TAC-induced cardiac hypertrophy/fibrosis by GSEA; its related pathways included activated cGMP-PKG and TGF-beta signaling based on enrichment results.	0.31
36003513	Frontiers in pharmacology	2022	Identification of circular RNAs in cardiac hypertrophy and cardiac fibrosis.		mmu-Hecw2_0009	mmu_circ_Hecw2	Hecw2	cardiac hypertrophy 	MONDO:0005045	hypertrophic cardiomyopathy	up-regulated	RT-qPCR; RNA-seq	"mmu-Hecw2_0009 is up-regulated in TAC hearts (notably at 4 weeks), is enriched in cardiomyocytes, and its knockdown reduces phenylephrine-induced cardiomyocyte hypertrophy. The study also predicts a ceRNA axis mmu-Hecw2_0009/miR-346-3p targeting fibrosis-related genes (e.g., Col4a2, Col5a3)."	0.6676
36003513	Frontiers in pharmacology	2022	Identification of circular RNAs in cardiac hypertrophy and cardiac fibrosis.		mmu-Itgbl1_0002	mmu_circ_Itgbl1	Itgbl1	cardiac hypertrophy 	MONDO:0005045	hypertrophic cardiomyopathy	up-regulated	RT-qPCR; RNA-seq	"mmu-Itgbl1_0002 is up-regulated in TAC hearts at 4 weeks and is mainly expressed in cardiac fibroblasts, suggesting association with the fibrotic stage of pressure-overload cardiac remodeling."	0.5922
36003513	Frontiers in pharmacology	2022	Identification of circular RNAs in cardiac hypertrophy and cardiac fibrosis.		mmu-Lrrc2_0005	mmu_circ_Lrrc2	Lrrc2	cardiac hypertrophy 	MONDO:0005045	hypertrophic cardiomyopathy	unknown	RNA-seq	"mmu-Lrrc2_0005 was included in the constructed ceRNA network, with a predicted regulatory axis through miR-92a-2-5p to multiple target mRNAs implicated in remodeling/fibrosis-related biology."	0.31
36003513	Frontiers in pharmacology	2022	Identification of circular RNAs in cardiac hypertrophy and cardiac fibrosis.		mmu-Cpeb3_0007	mmu_circ_Cpeb3	Cpeb3	cardiac hypertrophy 	MONDO:0005045	hypertrophic cardiomyopathy	down-regulated	RT-qPCR; RNA-seq	"mmu-Cpeb3_0007 is down-regulated in TAC hearts (2w and 4w by qPCR). Enrichment analysis links it to activated AMPK signaling and inhibited PI3K-Akt and Hippo pathways, and a predicted ceRNA axis mmu-Cpeb3_0007/miR-92a-2-5p targeting Cacna2d2/Cdh8/Kcnj3."	0.5922
36003513	Frontiers in pharmacology	2022	Identification of circular RNAs in cardiac hypertrophy and cardiac fibrosis.		mmu-Ryr2_0040	mmu_circ_Ryr2	Ryr2	cardiac hypertrophy 	MONDO:0005045	hypertrophic cardiomyopathy	down-regulated	RT-qPCR; RNA-seq	mmu-Ryr2_0040 is down-regulated in TAC hearts at 4 weeks (qPCR-validated) and is mainly expressed in cardiomyocytes. The study constructs ceRNA axes involving miR-103-3p and miR-185-5p with downstream targets (Celsr2/Prmt8; Ccbe1/Lrrc15) and links it to myocardial metabolism/cardiac function-related enrichment results.	0.5922
36003513	Frontiers in pharmacology	2022	Identification of circular RNAs in cardiac hypertrophy and cardiac fibrosis.		mmu-Rtn4_0001	mmu_circ_Rtn4	Rtn4	cardiac hypertrophy 	MONDO:0005045	hypertrophic cardiomyopathy	unknown	RNA-seq	"mmu-Rtn4_0001 was identified by GSEA as a key circRNA associated with cardiac hypertrophy/cardiac fibrosis pathways in the TAC model, but its expression direction and specific downstream interactions were not reported in the provided text."	0.31
36006268	Tropical medicine and infectious disease	2022	Expression Profile Analysis of Circular RNAs in Leishmaniasis.		chr13: 30251931_30257867			Leishmaniasis	MONDO:0011989	leishmaniasis	up-regulated	RNA-seq	"This circRNA (reported only by genomic coordinate) is among the top up-regulated serum circRNAs in leishmaniasis patients versus healthy controls identified by RNA-seq. No specific function, mechanism, or axis for this individual circRNA was experimentally validated in the paper."	0.1768
36006268	Tropical medicine and infectious disease	2022	Expression Profile Analysis of Circular RNAs in Leishmaniasis.		chr 6: 31271073_31355592			Leishmaniasis	MONDO:0011989	leishmaniasis	up-regulated	RNA-seq	This circRNA (reported only by genomic coordinate) is listed among the top up-regulated serum circRNAs in leishmaniasis patients compared with controls based on RNA-seq. The study did not report specific validated functions or mechanisms for this individual circRNA.	0.1768
36006268	Tropical medicine and infectious disease	2022	Expression Profile Analysis of Circular RNAs in Leishmaniasis.		chr 13: 30280063_30283791			Leishmaniasis	MONDO:0011989	leishmaniasis	up-regulated	RNA-seq	This circRNA is identified by RNA-seq as a top up-regulated serum circRNA in leishmaniasis patients versus controls. No circRNA-specific functional experiments were performed for it.	0.1155
36006268	Tropical medicine and infectious disease	2022	Expression Profile Analysis of Circular RNAs in Leishmaniasis.		chr 6: 29887955_29942626			Leishmaniasis	MONDO:0011989	leishmaniasis	up-regulated	RNA-seq	This circRNA is one of the top up-regulated serum circRNAs in leishmaniasis patients identified by RNA-seq. The paper provides no circRNA-specific functional/mechanistic validation for it.	0.1155
36006268	Tropical medicine and infectious disease	2022	Expression Profile Analysis of Circular RNAs in Leishmaniasis.		chr 6: 29829418_29888742			Leishmaniasis	MONDO:0011989	leishmaniasis	up-regulated	RNA-seq	This circRNA is reported as significantly up-regulated in serum from leishmaniasis patients in the RNA-seq screen. The authors note that the screened differentially expressed circRNAs require further validation.	0.1155
36006268	Tropical medicine and infectious disease	2022	Expression Profile Analysis of Circular RNAs in Leishmaniasis.		chr13: 30621764_30647057			Leishmaniasis	MONDO:0011989	leishmaniasis	up-regulated	RNA-seq	"This circRNA is a top up-regulated serum circRNA in leishmaniasis patients in this RNA-seq profiling study, without individual experimental validation or mechanistic characterization."	0.1155
36006268	Tropical medicine and infectious disease	2022	Expression Profile Analysis of Circular RNAs in Leishmaniasis.		chr 1: 35850157_35851053			Leishmaniasis	MONDO:0011989	leishmaniasis	up-regulated	RNA-seq	"This circRNA is reported as significantly up-regulated in serum of leishmaniasis patients versus controls in RNA-seq profiling, with no individual downstream validation described."	0.1155
36006268	Tropical medicine and infectious disease	2022	Expression Profile Analysis of Circular RNAs in Leishmaniasis.		chr1: 244408712_244430099			Leishmaniasis	MONDO:0011989	leishmaniasis	up-regulated	RNA-seq	This circRNA is among the top up-regulated serum circRNAs in leishmaniasis patients identified by RNA-seq; its specific biological role was not characterized.	0.1155
36006268	Tropical medicine and infectious disease	2022	Expression Profile Analysis of Circular RNAs in Leishmaniasis.		chr 7: 77083887_77098951			Leishmaniasis	MONDO:0011989	leishmaniasis	up-regulated	RNA-seq	"This circRNA is listed as a top up-regulated serum circRNA in leishmaniasis from RNA-seq profiling, with no dedicated functional/mechanistic validation."	0.1155
36006268	Tropical medicine and infectious disease	2022	Expression Profile Analysis of Circular RNAs in Leishmaniasis.		chr 6: 3410188_3438555			Leishmaniasis	MONDO:0011989	leishmaniasis	up-regulated	RNA-seq	This circRNA is reported as significantly up-regulated in serum of leishmaniasis patients based on RNA-seq differential expression analysis; no specific mechanistic axis was validated for it.	0.1155
36006268	Tropical medicine and infectious disease	2022	Expression Profile Analysis of Circular RNAs in Leishmaniasis.		chr 6: 32521905_32581838			Leishmaniasis	MONDO:0011989	leishmaniasis	down-regulated	RNA-seq	This circRNA is listed among the top down-regulated serum circRNAs in leishmaniasis patients based on RNA-seq differential expression analysis. No individual functional mechanism was validated.	0.1155
36006268	Tropical medicine and infectious disease	2022	Expression Profile Analysis of Circular RNAs in Leishmaniasis.		chr 12: 2866393_2872244			Leishmaniasis	MONDO:0011989	leishmaniasis	down-regulated	RNA-seq	"This circRNA is a top down-regulated serum circRNA in leishmaniasis patients versus controls from the RNA-seq screen, without further validation in this paper."	0.1155
36006268	Tropical medicine and infectious disease	2022	Expression Profile Analysis of Circular RNAs in Leishmaniasis.		chr17: 16034765_16040494			Leishmaniasis	MONDO:0011989	leishmaniasis	down-regulated	RNA-seq	"This circRNA is reported among the top down-regulated serum circRNAs in leishmaniasis patients based on RNA-seq profiling, without circRNA-specific validation."	0.1155
36006268	Tropical medicine and infectious disease	2022	Expression Profile Analysis of Circular RNAs in Leishmaniasis.		chr 1: 11016844_11020599			Leishmaniasis	MONDO:0011989	leishmaniasis	down-regulated	RNA-seq	This circRNA is one of the top down-regulated serum circRNAs in leishmaniasis patients from the RNA-seq analysis; no individual mechanistic validation was provided.	0.1155
36006268	Tropical medicine and infectious disease	2022	Expression Profile Analysis of Circular RNAs in Leishmaniasis.		chr11: 20407911_20426865			Leishmaniasis	MONDO:0011989	leishmaniasis	down-regulated	RNA-seq	"This circRNA is a top down-regulated serum circRNA in leishmaniasis patients from RNA-seq profiling, with no circRNA-specific functional characterization reported."	0.1155
36006268	Tropical medicine and infectious disease	2022	Expression Profile Analysis of Circular RNAs in Leishmaniasis.		chr17: 63666940_63685578			Leishmaniasis	MONDO:0011989	leishmaniasis	down-regulated	RNA-seq	"This circRNA is reported as one of the top down-regulated serum circRNAs in leishmaniasis patients compared with controls from RNA-seq analysis, without further validation."	0.1155
36006268	Tropical medicine and infectious disease	2022	Expression Profile Analysis of Circular RNAs in Leishmaniasis.		chr 1: 23971573_23972012			Leishmaniasis	MONDO:0011989	leishmaniasis	down-regulated	RNA-seq	"This circRNA is reported as a top down-regulated serum circRNA in leishmaniasis patients in the RNA-seq screen, with no specific functional validation reported."	0.1155
36006268	Tropical medicine and infectious disease	2022	Expression Profile Analysis of Circular RNAs in Leishmaniasis.		chr2: 171435083_171458075			Leishmaniasis	MONDO:0011989	leishmaniasis	down-regulated	RNA-seq	"This circRNA is a top down-regulated serum circRNA in leishmaniasis patients from RNA-seq profiling, with no further validation or mechanistic analysis reported for it specifically."	0.1155
36006268	Tropical medicine and infectious disease	2022	Expression Profile Analysis of Circular RNAs in Leishmaniasis.		chr1: 235812971_235833667			Leishmaniasis	MONDO:0011989	leishmaniasis	down-regulated	RNA-seq	This circRNA is among the top down-regulated serum circRNAs in leishmaniasis patients identified by RNA-seq; the study does not provide circRNA-specific functional mechanisms.	0.1155
36006268	Tropical medicine and infectious disease	2022	Expression Profile Analysis of Circular RNAs in Leishmaniasis.		chr12: 102269600_102315490			Leishmaniasis	MONDO:0011989	leishmaniasis	down-regulated	RNA-seq	"This circRNA is reported among the top down-regulated serum circRNAs in leishmaniasis patients from RNA-seq profiling, without specific validation or functional characterization."	0.1155
36008392	Cell death & disease	2022	Circular RNA hsa_circ_0007367 promotes the progression of pancreatic ductal adenocarcinoma by sponging miR-6820-3p and upregulating YAP1 expression.	hsa_circ_0007367		hsa_circ_UBAP2	UBAP2	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; ISH; Microarray	"hsa_circ_0007367 (derived from UBAP2) is up-regulated in PDAC tissues and cell lines and predominantly localizes to the cytoplasm. It promotes PDAC proliferation, migration/invasion, and tumor growth by acting as a ceRNA that sponges miR-6820-3p, thereby upregulating YAP1. Clinically, high hsa_circ_0007367 is associated with aggressive clinicopathological features and poorer prognosis in PDAC."	0.8456
36011395	Genes	2022	Circular Noncoding RNA hsa_circ_0003570 as a Prognostic Biomarker for Hepatocellular Carcinoma.	hsa_circ_0003570				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"In HCC clinical tissues, hsa_circ_0003570 is down-regulated in tumors versus adjacent noncancerous liver tissue. Higher expression predicts better overall and progression-free survival, supporting its potential as a prognostic biomarker; no mechanism was experimentally investigated in this study."	0.4758
36016851	Disease markers	2022	circCNN2 Accelerates Cell Proliferation and Invasion in Lung Squamous Cell Carcinoma via Regulating miR-184/E2F1 and Activating MAPK Signaling Pathway.		circRNA_102399 / circCNN2	hsa_circ_CNN2	CNN2	lung squamous cell carcinoma / LUSC	MONDO:0005097	squamous cell lung carcinoma	up-regulated	RT-qPCR	"circCNN2 is up-regulated in LUSC cell lines and promotes proliferation, invasion, and xenograft tumor growth. Mechanistically, it functions as a ceRNA that sponges miR-184 to increase E2F1, which transcriptionally elevates ASK1 and activates MAPK signaling."	0.8299
36018563	Endocrine connections	2022	Circular RNA profile in Graves' disease and potential function of hsa_circ_0090364.	hsa_circ_0090364		hsa_circ_JADE3	JADE3	Graves¡¯ disease / GD	MONDO:0005364	Graves disease	up-regulated	RT-qPCR; Microarray	hsa_circ_0090364 is up-regulated in Graves¡¯ disease patient plasma and PBMCs and correlates positively with TRAb. It promotes Jurkat T-cell proliferation and may function as a ceRNA by sponging hsa-miR-378a-3p to increase IL-6ST/IL21R and activate JAK/STAT signaling.	0.6046
36028854	Journal of experimental & clinical cancer research : CR	2022	ALKBH5-mediated m6A modification of circCCDC134 facilitates cervical cancer metastasis by enhancing HIF1A transcription.	hsa_circ_0008806	circCCDC134	hsa_circ_CCDC134	CCDC134	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; RNA-seq	"circCCDC134 is up-regulated in cervical cancer (especially metastatic tissues) and promotes proliferation, migration, invasion and metastasis. Mechanistically, ALKBH5-mediated m6A modulation affects its stability via YTHDF2; circCCDC134 recruits p65 to enhance HIF1A transcription and sponges hsa-miR-503-5p to upregulate MYB, which further stimulates HIF1A transcription."	0.8871
36030248	Cell death & disease	2022	CircKIF4A promotes glioma growth and temozolomide resistance by accelerating glycolysis.	hsa_circ_0007255	circKIF4A	hsa_circ_KIF4A	KIF4A	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circKIF4A is up-regulated in glioma tissues and cell lines and promotes tumor growth, proliferation, invasion/migration, glycolysis, and temozolomide resistance. Mechanistically, it mainly localizes in the cytoplasm and acts as a ceRNA by binding miR-335-5p to relieve repression of ALDOA, enhancing glycolysis and malignant phenotypes."	0.8443
36035170	Frontiers in genetics	2022	Bioinformatic analysis of circular RNA expression profiles in a rat lumbosacral spinal root avulsion model.		circRNA_7025	rno_circ_Atad2b	Atad2b	lumbosacral spinal root avulsion / LSRA	MONDO:0002959	radiculopathy	down-regulated	RT-qPCR; RNA-seq	"circRNA_7025 is down-regulated in rat spinal cord tissue after LSRA and also decreases after OGD in primary spinal neurons. It directly binds rno-miR-1224 and rno-miR-326-5p, and circRNA_7025 overexpression reduces OGD-induced neuronal apoptosis, indicating a protective anti-apoptotic role via a circRNA_7025/miR-1224/miR-326-5p axis."	0.7082
36035170	Frontiers in genetics	2022	Bioinformatic analysis of circular RNA expression profiles in a rat lumbosacral spinal root avulsion model.		circRNA_6405			lumbosacral spinal root avulsion / LSRA	MONDO:0002959	radiculopathy	up-regulated	RT-qPCR; RNA-seq	circRNA_6405 is up-regulated in rat spinal cord tissue after LSRA and was among the eight circRNAs whose differential expression was validated by qRT-PCR consistent with RNA-seq.	0.4625
36035170	Frontiers in genetics	2022	Bioinformatic analysis of circular RNA expression profiles in a rat lumbosacral spinal root avulsion model.		circRNA_0320			lumbosacral spinal root avulsion / LSRA	MONDO:0002959	radiculopathy	up-regulated	RT-qPCR; RNA-seq	circRNA_0320 is up-regulated in rat spinal cord tissue after LSRA and its differential expression was validated by qRT-PCR consistent with RNA-seq.	0.4625
36035170	Frontiers in genetics	2022	Bioinformatic analysis of circular RNA expression profiles in a rat lumbosacral spinal root avulsion model.		circRNA_1538			lumbosacral spinal root avulsion / LSRA	MONDO:0002959	radiculopathy	up-regulated	RT-qPCR; RNA-seq	circRNA_1538 is up-regulated in rat spinal cord tissue after LSRA and its differential expression was validated by qRT-PCR consistent with RNA-seq.	0.4625
36035170	Frontiers in genetics	2022	Bioinformatic analysis of circular RNA expression profiles in a rat lumbosacral spinal root avulsion model.		circRNA_1211			lumbosacral spinal root avulsion / LSRA	MONDO:0002959	radiculopathy	up-regulated	RT-qPCR; RNA-seq	circRNA_1211 is up-regulated in rat spinal cord tissue after LSRA and its differential expression was validated by qRT-PCR consistent with RNA-seq.	0.4625
36035170	Frontiers in genetics	2022	Bioinformatic analysis of circular RNA expression profiles in a rat lumbosacral spinal root avulsion model.		circRNA_8944			lumbosacral spinal root avulsion / LSRA	MONDO:0002959	radiculopathy	down-regulated	RT-qPCR; RNA-seq	circRNA_8944 is down-regulated in rat spinal cord tissue after LSRA and its differential expression was validated by qRT-PCR consistent with RNA-seq.	0.4625
36035170	Frontiers in genetics	2022	Bioinformatic analysis of circular RNA expression profiles in a rat lumbosacral spinal root avulsion model.		circRNA_0336			lumbosacral spinal root avulsion / LSRA	MONDO:0002959	radiculopathy	down-regulated	RT-qPCR; RNA-seq	circRNA_0336 is down-regulated in rat spinal cord tissue after LSRA and its differential expression was validated by qRT-PCR consistent with RNA-seq.	0.4625
36035170	Frontiers in genetics	2022	Bioinformatic analysis of circular RNA expression profiles in a rat lumbosacral spinal root avulsion model.		circRNA_4914			lumbosacral spinal root avulsion / LSRA	MONDO:0002959	radiculopathy	down-regulated	RT-qPCR; RNA-seq	circRNA_4914 is down-regulated in rat spinal cord tissue after LSRA and its differential expression was validated by qRT-PCR consistent with RNA-seq.	0.4625
36035287	Computational and mathematical methods in medicine	2022	circ_0041795 Induces YAP1 Upregulation to Accelerate the Progression of Diabetic Retinopathy through Binding to miR-589-5p.	hsa_circ_0041795	circ_0041795			diabetic retinopathy / DR	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR	"In HG-treated human ARPE-19 cells (an in vitro DR model), circ_0041795 is up-regulated and promotes cell injury by reducing viability/proliferation and increasing apoptosis, inflammatory cytokine release, and oxidative stress. Mechanistically, it sponges miR-589-5p to relieve repression of YAP1, thereby activating NF-kappaB signaling via the miR-589-5p/YAP1 axis."	0.6959
36035366	International journal of medical sciences	2022	"Hsa_circ_0087302, a circular RNA, affects the progression of osteosarcoma via the Wnt/beta-catenin signaling pathway."	hsa_circ_0087302	circ-0087302	hsa_circ_TLE4	TLE4	osteosarcoma / OS	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0087302 is down-regulated in osteosarcoma cells. Its overexpression suppresses osteosarcoma malignant behaviors (proliferation, G0/G1 cell-cycle progression, migration, invasion), at least in part by inhibiting Wnt/beta-catenin signaling (decreasing beta-catenin and multiple downstream targets while increasing Axin)."	0.5997
36038948	Journal of hematology & oncology	2022	CircRNA-CREIT inhibits stress granule assembly and overcomes doxorubicin resistance in TNBC by destabilizing PKR.	hsa_circ_0001798	circRNA-CREIT	hsa_circ_SPIDR	SPIDR	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	down-regulated	RT-qPCR; ISH; RNA-seq	"circRNA-CREIT (hsa_circ_0001798, from SPIDR exons 6_7) is down-regulated in breast cancer/TNBC, especially in doxorubicin-resistant settings. It increases doxorubicin sensitivity by acting as a scaffold that enhances HACE1-mediated K48-linked ubiquitination and proteasomal degradation of PKR, thereby suppressing the PKR/eIF2alpha axis, inhibiting stress granule assembly, and enabling RACK1/MTK1-mediated apoptosis. Clinically, higher circRNA-CREIT correlates with favorable prognosis and it is detectable in plasma with diagnostic potential."	0.8986
36041244	Environment international	2022	Prediction of COPD acute exacerbation in response to air pollution using exosomal circRNA profile and Machine learning.	hsa_circ_0005045	circ_0005045 / hsa_circRNA_0005045	hsa_circ_RTN4	RTN4	chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR; Microarray	"This study identifies exosomal hsa_circ_0005045 as PM2.5-inducible and elevated in COPD patient plasma after exposure. It binds PRDX2 in exosomes and is linked to PRDX2/ELANE/TNF-alpha inflammatory signaling that aggravates COPD-like lesions, and its higher level helps characterize PM2.5-sensitive COPD patients at risk of aeCOPD."	0.8323
36041244	Environment international	2022	Prediction of COPD acute exacerbation in response to air pollution using exosomal circRNA profile and Machine learning.	mmu_circ_0002950	circ_0002950	mmu_circ_RTN4	RTN4	chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR	"In mice exposed to PM2.5, exosomal mmu_circ_0002950 is elevated in BALF and plasma and contributes to COPD-like pathological changes. In vivo knockdown of mmu_circ_0002950 (AAV6 shRNA) reduces inflammatory cell infiltration and suppresses PRDX2/TNF-alpha/ELANE-associated responses, rescuing emphysema and fibrosis features."	0.6099
36042613	Medicine	2022	Bioinformatics analysis of the circRNA-miRNA-mRNA network for atrial fibrillation.	hsa_circ_0056281	hsa_circRNA_0056281	hsa_circ_EPB41L5	EPB41L5	atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	up-regulated	Microarray	"hsa_circ_0056281 is upregulated in AF atrial appendage tissue and is predicted to act in a ceRNA axis by interacting with hsa-miR-613 and thereby regulating CXCR4/CXCR2/CXCL11, potentially contributing to AF-related inflammation/atrial remodeling processes."	0.1768
36042613	Medicine	2022	Bioinformatics analysis of the circRNA-miRNA-mRNA network for atrial fibrillation.	hsa_circ_0006665	hsa_circRNA_0006665	hsa_circ_FAM188A	FAM188A	atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	up-regulated	Microarray	"hsa_circ_0006665 is upregulated in AF atrial tissue and is predicted to participate in a ceRNA subnetwork by binding hsa-miR-613 and associating with CXCR4/CXCR2/CXCL11, suggesting a potential role in AF pathogenesis."	0.1768
36042613	Medicine	2022	Bioinformatics analysis of the circRNA-miRNA-mRNA network for atrial fibrillation.	hsa_circ_0003638	hsa_circRNA_0003638	hsa_circ_NLK	NLK	atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	up-regulated	Microarray	"hsa_circ_0003638 is upregulated in AF atrial tissue and is predicted to regulate CXCR4 by sponging hsa-miR-1207-3p, potentially contributing to AF-associated cardiac injury and atrial remodeling."	0.1768
36042613	Medicine	2022	Bioinformatics analysis of the circRNA-miRNA-mRNA network for atrial fibrillation.	hsa_circ_0058794		hsa_circ_AGAP1	AGAP1	atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	down-regulated	Microarray	"hsa_circ_0058794 is predicted to be downregulated in AF atrial tissue and to participate in a ceRNA axis with hsa-miR-3667-5p and C3, suggesting a potential link to AF-related inflammatory/immune regulation."	0.1768
36042613	Medicine	2022	Bioinformatics analysis of the circRNA-miRNA-mRNA network for atrial fibrillation.	hsa_circ_0004163		hsa_circ_TYMS	TYMS	atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	down-regulated	Microarray	"hsa_circ_0004163 is predicted to be downregulated in AF atrial tissue and to participate in ceRNA axes with hsa-miR-1179 targeting NMU and BDKRB1, suggesting a possible involvement in AF-associated inflammatory/fibrotic regulation."	0.1768
36045408	Molecular cancer	2022	CircSMARCC1 facilitates tumor progression by disrupting the crosstalk between prostate cancer cells and tumor-associated macrophages via miR-1322/CCL20/CCR6 signaling.	hsa_circ_0001296	circSMARCC1	hsa_circ_SMARCC1	SMARCC1	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; ISH; RNA-seq; Microarray	"circSMARCC1 is up-regulated in prostate cancer and promotes proliferation, migration/invasion, and in vivo tumor growth/metastasis. It functions mainly in the cytoplasm as a ceRNA that sponges miR-1322 to de-repress CCL20, activates PI3K/AKT signaling, and enhances TAM recruitment and M2 polarization via the CCL20/CCR6 axis, contributing to PCa progression and poorer clinical outcomes."	0.8898
36046641	Journal of Cancer	2022	Circ_0039908/miR-let-7c/RRM2 axis was identified played an important role in lung adenocarcinoma by integrated analysis.	hsa_circ_0039908	circRNA_0039908 / circ_0039908	hsa_circ_DUS2L	DUS2L	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0039908 (host gene DUS2L) is up-regulated in LUAD tissues/cells and promotes malignant phenotypes. Its knockdown increases miR-let7c-5p and decreases RRM2, suppressing proliferation, migration and invasion, consistent with a circ_0039908/miR-let-7c/RRM2 ceRNA axis and associated changes in p-AKT/p-ERK and EMT markers."	0.6758
36051440	Frontiers in cell and developmental biology	2022	"RNA sequencing profiling of mRNAs, long noncoding RNAs, and circular RNAs in Trigeminal Ganglion following Temporomandibular Joint inflammation."		Nbea	mmu_circ_Nbea	Nbea	temporomandibular joint disorders	MONDO:0005473	temporomandibular joint disorder	dysregulated	RT-qPCR; RNA-seq	"This study identified circRNA derived from Nbea as differentially expressed in trigeminal ganglion in a CFA-induced TMD inflammation pain mouse model, and validated its altered expression by RT-qPCR consistent with RNA-seq."	0.1904
36051440	Frontiers in cell and developmental biology	2022	"RNA sequencing profiling of mRNAs, long noncoding RNAs, and circular RNAs in Trigeminal Ganglion following Temporomandibular Joint inflammation."		Trim23	mmu_circ_Trim23	Trim23	temporomandibular joint disorders	MONDO:0005473	temporomandibular joint disorder	dysregulated	RT-qPCR; RNA-seq	Trim23-derived circRNA was among the differentially expressed circRNAs in trigeminal ganglion after CFA-induced TMD inflammation pain and was validated by RT-qPCR consistent with RNA-seq.	0.1904
36051440	Frontiers in cell and developmental biology	2022	"RNA sequencing profiling of mRNAs, long noncoding RNAs, and circular RNAs in Trigeminal Ganglion following Temporomandibular Joint inflammation."		Hmgxb3	mmu_circ_Hmgxb3	Hmgxb3	temporomandibular joint disorders	MONDO:0005473	temporomandibular joint disorder	dysregulated	RT-qPCR; RNA-seq	Hmgxb3-derived circRNA was identified as differentially expressed in TG in the CFA-induced TMD pain model and its altered expression was confirmed by RT-qPCR consistent with sequencing.	0.1904
36051440	Frontiers in cell and developmental biology	2022	"RNA sequencing profiling of mRNAs, long noncoding RNAs, and circular RNAs in Trigeminal Ganglion following Temporomandibular Joint inflammation."		Samd8	mmu_circ_Samd8	Samd8	temporomandibular joint disorders	MONDO:0005473	temporomandibular joint disorder	dysregulated	RT-qPCR; RNA-seq	Samd8-derived circRNA was selected for validation and showed altered expression in TG in the CFA-induced TMD inflammation pain model consistent with RNA-seq.	0.1904
36051440	Frontiers in cell and developmental biology	2022	"RNA sequencing profiling of mRNAs, long noncoding RNAs, and circular RNAs in Trigeminal Ganglion following Temporomandibular Joint inflammation."		Ireb2	mmu_circ_Ireb2	Ireb2	temporomandibular joint disorders	MONDO:0005473	temporomandibular joint disorder	dysregulated	RT-qPCR; RNA-seq	Ireb2-derived circRNA showed differential expression in trigeminal ganglion in the CFA-induced TMD inflammation pain model and was supported by RNA-seq and RT-qPCR validation.	0.1904
36051440	Frontiers in cell and developmental biology	2022	"RNA sequencing profiling of mRNAs, long noncoding RNAs, and circular RNAs in Trigeminal Ganglion following Temporomandibular Joint inflammation."		Hsdl2	mmu_circ_Hsdl2	Hsdl2	temporomandibular joint disorders	MONDO:0005473	temporomandibular joint disorder	dysregulated	RT-qPCR; RNA-seq	Hsdl2-derived circRNA was validated as differentially expressed in TG in a CFA-induced TMD inflammation pain mouse model.	0.1904
36051440	Frontiers in cell and developmental biology	2022	"RNA sequencing profiling of mRNAs, long noncoding RNAs, and circular RNAs in Trigeminal Ganglion following Temporomandibular Joint inflammation."		Pknox2	mmu_circ_Pknox2	Pknox2	temporomandibular joint disorders	MONDO:0005473	temporomandibular joint disorder	dysregulated	RT-qPCR; RNA-seq	Pknox2-derived circRNA was among the selected circRNAs whose differential expression in TG after CFA-induced TMD pain was confirmed by RT-qPCR.	0.1904
36051440	Frontiers in cell and developmental biology	2022	"RNA sequencing profiling of mRNAs, long noncoding RNAs, and circular RNAs in Trigeminal Ganglion following Temporomandibular Joint inflammation."		Pum1	mmu_circ_Pum1	Pum1	temporomandibular joint disorders	MONDO:0005473	temporomandibular joint disorder	dysregulated	RT-qPCR; RNA-seq	Pum1-derived circRNA was validated as differentially expressed in TG in a CFA-induced TMD inflammation pain mouse model.	0.1904
36051440	Frontiers in cell and developmental biology	2022	"RNA sequencing profiling of mRNAs, long noncoding RNAs, and circular RNAs in Trigeminal Ganglion following Temporomandibular Joint inflammation."		Gsr	mmu_circ_Gsr	Gsr	temporomandibular joint disorders	MONDO:0005473	temporomandibular joint disorder	dysregulated	RT-qPCR; RNA-seq	Gsr-derived circRNA was among the differentially expressed circRNAs in TG after CFA-induced TMD inflammation pain and was validated by RT-qPCR.	0.1904
36051440	Frontiers in cell and developmental biology	2022	"RNA sequencing profiling of mRNAs, long noncoding RNAs, and circular RNAs in Trigeminal Ganglion following Temporomandibular Joint inflammation."		Cwf19l2	mmu_circ_Cwf19l2	Cwf19l2	temporomandibular joint disorders	MONDO:0005473	temporomandibular joint disorder	dysregulated	RT-qPCR; RNA-seq	Cwf19l2-derived circRNA was validated as differentially expressed in TG in the CFA-induced TMD inflammation pain model.	0.1904
36051693	Frontiers in genetics	2022	Comprehensive circular RNA expression profile of lung adenocarcinoma with bone metastasis: Identification of potential biomarkers.	hsa_circ_0096442	circ_0096442			lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	dysregulated	RT-qPCR; RNA-seq	"In LUAD with bone metastasis, circ_0096442 is a markedly dysregulated circRNA detected in peripheral blood and validated by RT-qPCR. Functionally, it promotes A549 cell proliferation, migration and invasion while inhibiting apoptosis in a bone-microenvironment co-culture model, and it acts as a sponge for hsa-miR-326 with cytoplasmic co-localization and luciferase-validated binding."	0.6975
36052282	Journal of oncology	2022	Circular RNA KIF4A Promotes Liver Metastasis of Breast Cancer by Reprogramming Glucose Metabolism.		circKIF4A / circKIF4 	hsa_circ_KIF4A	KIF4A	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circKIF4A is up-regulated in primary breast cancer and liver metastasis tissues/cell lines and promotes metastatic behavior and glycolytic metabolic reprogramming. Mechanistically, it mainly localizes in the cytoplasm and sponges miR-335, thereby increasing ALDOA/OCT4 and downstream HK2/PKM2 expression to enhance glucose uptake and lactate production, promoting liver metastasis."	0.7437
36056804	Thoracic cancer	2022	"Circ_0002476 regulates cell growth, invasion, and mtDNA damage in non-small cell lung cancer by targeting miR-1182/TFAM axis."	hsa_circ_0002476	circ_0002476 / hsa_circRNA_100900			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0002476 is up-regulated in NSCLC and mainly localized in the cytoplasm. It promotes NSCLC proliferation, invasion and tumor growth while inhibiting apoptosis and mtDNA damage by sponging miR-1182 to upregulate TFAM, and it can be transported between cells via exosomes."	0.8428
36058922	Journal of translational medicine	2022	"circCRKL, a circRNA derived from CRKL, regulates BCR-ABL via sponging miR-877-5p to promote chronic myeloid leukemia cell proliferation."		circCRKL	hsa_circ_CRKL	CRKL	chronic myeloid leukemia / CML	MONDO:0011996	"chronic myelogenous leukemia, BCR-ABL1 positive"	up-regulated	RT-qPCR	"circCRKL is up-regulated in CML (especially BCR-ABL+ cells) and predominantly localizes to the cytoplasm. It promotes CML proliferation by sponging miR-877-5p in an AGO2-associated manner, thereby increasing BCR-ABL/ABL expression; circCRKL knockdown also increases imatinib sensitivity, potentially involving Wnt/beta-catenin signaling changes."	0.8491
36058942	Journal of translational medicine	2022	Radiated glioblastoma cell-derived exosomal circ_0012381 induce M2 polarization of microglia to promote the growth of glioblastoma by CCL2/CCR2 axis.	hsa_circ_0012381	circ_0012381			glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; RNA-seq	"In irradiated glioblastoma, circ_0012381 is upregulated and exported via tumor-cell exosomes into microglia. It functions as a ceRNA to sponge miR-340-5p, increasing ARG1 and driving M2 polarization with reduced phagocytosis, which in turn promotes irradiated GBM growth via the CCL2/CCR2 axis; radiation-induced C/EBPB contributes to higher circ_0012381 levels."	0.7718
36058953	Journal of translational medicine	2022	The potential of mecciRNA in hepatic stellate cell to regulate progression of nonalcoholic hepatitis.	hsa_circ_0089761				Nonalcoholic steatohepatitis / NASH	MONDO:0007027	metabolic dysfunction-associated steatohepatitis	down-regulated	RT-qPCR; Microarray	"hsa_circ_0089761 is down-regulated in NASH HSCs and in LPS-activated LX-2 cells. It is proposed to act as a ceRNA/miRNA sponge in a mecciRNA-miRNA-mRNA network, potentially regulating fibrosis-related signaling (including enrichment of TGF-beta and Hippo pathways) with core downstream targets such as SMAD2/3 and c-MYC."	0.508
36058953	Journal of translational medicine	2022	The potential of mecciRNA in hepatic stellate cell to regulate progression of nonalcoholic hepatitis.	hsa_circ_0089763				Nonalcoholic steatohepatitis / NASH	MONDO:0007027	metabolic dysfunction-associated steatohepatitis	down-regulated	RT-qPCR; Microarray	"hsa_circ_0089763 is down-regulated in NASH HSCs and in LPS-activated LX-2 cells. It is proposed to function as a ceRNA/miRNA sponge together with hsa_circ_0089761 in a mecciRNA-miRNA-mRNA network linked to fibrosis-related signaling, with enriched pathways including TGF-beta and Hippo and core targets such as SMAD2/3 and c-MYC."	0.508
36059637	Frontiers in oncology	2022	Comprehensive analysis of m6A circRNAs identified in colorectal cancer by MeRIP sequencing.	hsa_circ_0032821	Circ_0032821			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	This study identified has_circ_0032821 as up-regulated in colorectal cancer tissues versus adjacent normal tissues based on RNA-seq and RT-qPCR validation. No CRC-specific downstream miRNA/mRNA axis or functional assays were reported for this circRNA in this paper.	0.4032
36059637	Frontiers in oncology	2022	Comprehensive analysis of m6A circRNAs identified in colorectal cancer by MeRIP sequencing.	hsa_circ_0019079	circKIF20B	hsa_circ_KIF20B	KIF20B	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"The study reports that hsa_circ_0019079 (circKIF20B) is up-regulated in colorectal cancer tissues versus adjacent normal tissues, supported by RNA-seq and RT-qPCR. Network analysis suggests it is part of a circRNA-miRNA-mRNA co-expression framework and may positively regulate SLC31A1, but specific miRNAs were not provided for this circRNA."	0.5135
36059637	Frontiers in oncology	2022	Comprehensive analysis of m6A circRNAs identified in colorectal cancer by MeRIP sequencing.	hsa_circ_0093688		hsa_circ_AKR1E2	AKR1E2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0093688 is reported as hyper-methylated and up-regulated in colorectal cancer tissues compared with adjacent normal controls, with RT-qPCR validation of its increased expression. The paper does not provide a specific downstream miRNA/mRNA mechanism for this circRNA."	0.4032
36059637	Frontiers in oncology	2022	Comprehensive analysis of m6A circRNAs identified in colorectal cancer by MeRIP sequencing.	hsa_circ_0026782	circITGA7	hsa_circ_ITGA7	ITGA7	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	The paper validates that hsa_circ_0026782 is down-regulated in colorectal cancer tissues versus adjacent normal controls by RNA-seq and RT-qPCR. No CRC-specific mechanistic axis is experimentally established for hsa_circ_0026782 within this study.	0.3588
36059637	Frontiers in oncology	2022	Comprehensive analysis of m6A circRNAs identified in colorectal cancer by MeRIP sequencing.	hsa_circ_0108457	circSETBP1	hsa_circ_SETBP1	SETBP1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"The study reports hsa_circ_0108457 (circSETBP1) as down-regulated in colorectal cancer tissues versus adjacent normal tissues and confirms its back-splicing by computational validation, with expression trend validated by RT-qPCR. No specific miRNA or downstream target mechanism is established for this circRNA in the paper."	0.5135
36059681	Frontiers in oncology	2022	Expression and clinical value of circRNAs in serum extracellular vesicles for gastric cancer.			hsa_circ_XLOC_008785	XLOC_008785	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	Chr10q11 is an extracellular-vesicle circRNA elevated in gastric cancer patient serum EVs and is associated with more advanced clinicopathological features. It shows diagnostic value (AUC 0.726) and is included in a predicted circRNA-miRNA-mRNA (ceRNA) network.	0.6556
36059681	Frontiers in oncology	2022	Expression and clinical value of circRNAs in serum extracellular vesicles for gastric cancer.			hsa_circ_XLOC_000992	XLOC_000992	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	Chr1p11 is an extracellular-vesicle circRNA elevated in gastric cancer patient serum EVs and is associated with more advanced clinicopathological features. It has diagnostic value (AUC 0.822) and is included in a predicted circRNA-miRNA-mRNA (ceRNA) network.	0.6556
36059681	Frontiers in oncology	2022	Expression and clinical value of circRNAs in serum extracellular vesicles for gastric cancer.		Chr7q11			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	Chr7q11 is an extracellular-vesicle circRNA elevated in gastric cancer patient serum EVs and is associated with more advanced clinicopathological features. It shows diagnostic value (AUC 0.749) and is included in a predicted circRNA-miRNA-mRNA (ceRNA) network.	0.6556
36059806	Journal of oncology	2022	CircLMTK2 Silencing Attenuates Gemcitabine Resistance in Pancreatic Cancer by Sponging miR-485-5p and to Target PAK1.		circLMTK2	hsa_circ_LMTK2	LMTK2	pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"circLMTK2 is up-regulated in pancreatic cancer and further increased in gemcitabine-resistant samples. It promotes GEM-resistant phenotypes by acting as a ceRNA that sponges miR-485-5p, thereby relieving repression of PAK1 and enhancing proliferation/migration/invasion while inhibiting apoptosis; silencing circLMTK2 reduces tumor growth in a xenograft model."	0.7859
36059813	Journal of oncology	2022	CircEPSTI1 Promotes the Proliferation of HER2-Positive Breast Cancer Cells via circEPSTI1/miR-145/ERBB3 Axis.	hsa_circ_0000479	circEPSTI1 / circ0000479	hsa_circ_EPSTI1	EPSTI1	HER2-positive breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circEPSTI1 is up-regulated in HER2-positive breast cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes proliferation, migration and invasion by acting as a ceRNA sponge for miR-145, thereby relieving repression of ERBB3."	0.7785
36061613	Frontiers in neuroscience	2022	Identification of potential key circular RNAs related to cognitive impairment after chronic constriction injury of the sciatic nerve.		Chr6:76491315_76492176			chronic neuropathic pain	MONDO:0021667	neuralgia	up-regulated	RT-qPCR	Chr6:76491315_76492176 is up-regulated in rat hippocampus 21 days after CCI with cognitive dysfunction. It is proposed to participate in cognitive impairment potentially through a predicted circRNA-miRNA-mRNA network linked to neuroinflammation and neuronal apoptosis.	0.4535
36061613	Frontiers in neuroscience	2022	Identification of potential key circular RNAs related to cognitive impairment after chronic constriction injury of the sciatic nerve.		Chr8:126307382_126317853			chronic neuropathic pain	MONDO:0021667	neuralgia	up-regulated	RT-qPCR	Chr8:126307382_126317853 is increased in hippocampus of CCI rats with cognitive dysfunction. The study predicts it may act through a circRNA-miRNA-mRNA network related to inflammation and apoptosis.	0.31
36061613	Frontiers in neuroscience	2022	Identification of potential key circular RNAs related to cognitive impairment after chronic constriction injury of the sciatic nerve.		Chr12:9292180_9313769			chronic neuropathic pain	MONDO:0021667	neuralgia	up-regulated	RT-qPCR	Chr12:9292180_9313769 is up-regulated in hippocampus after CCI-associated cognitive dysfunction. It is analyzed within a predicted circRNA-miRNA-mRNA network and implicated in inflammation/apoptosis-related mechanisms.	0.31
36061613	Frontiers in neuroscience	2022	Identification of potential key circular RNAs related to cognitive impairment after chronic constriction injury of the sciatic nerve.		Chr7:134659946_134667817			chronic neuropathic pain	MONDO:0021667	neuralgia	up-regulated	RT-qPCR	Chr7:134659946_134667817 is up-regulated in rat hippocampus after CCI with cognitive dysfunction. It is included in predicted ceRNA analyses connecting dysregulated circRNAs to inflammation and apoptosis.	0.31
36061613	Frontiers in neuroscience	2022	Identification of potential key circular RNAs related to cognitive impairment after chronic constriction injury of the sciatic nerve.		Chr10:18218676_18238682			chronic neuropathic pain	MONDO:0021667	neuralgia	up-regulated	RT-qPCR	Chr10:18218676_18238682 is up-regulated in CCI rat hippocampus with cognitive dysfunction. The paper predicts it functions through circRNA-miRNA-mRNA regulatory relationships associated with neuroinflammation and neuronal apoptosis.	0.31
36061613	Frontiers in neuroscience	2022	Identification of potential key circular RNAs related to cognitive impairment after chronic constriction injury of the sciatic nerve.		Chr6:136059672_136091144			chronic neuropathic pain	MONDO:0021667	neuralgia	down-regulated	RT-qPCR	Chr6:136059672_136091144 is down-regulated in hippocampus of CCI rats with cognitive dysfunction. The study places it in a predicted circRNA-miRNA-mRNA network associated with inflammation and apoptosis mechanisms.	0.31
36061613	Frontiers in neuroscience	2022	Identification of potential key circular RNAs related to cognitive impairment after chronic constriction injury of the sciatic nerve.		Chr11:87902732_87908586			chronic neuropathic pain	MONDO:0021667	neuralgia	down-regulated	RT-qPCR	Chr11:87902732_87908586 is down-regulated in CCI rat hippocampus with cognitive dysfunction. It is part of predicted circRNA-miRNA-mRNA regulatory analysis linked to inflammation and apoptosis.	0.31
36061613	Frontiers in neuroscience	2022	Identification of potential key circular RNAs related to cognitive impairment after chronic constriction injury of the sciatic nerve.		Chr2:104882050_104908155			chronic neuropathic pain	MONDO:0021667	neuralgia	down-regulated	RT-qPCR	Chr2:104882050_104908155 is decreased in hippocampus after CCI with cognitive dysfunction. It is incorporated into predicted circRNA-miRNA-mRNA networks connected to inflammation/apoptosis-related mechanisms.	0.31
36061613	Frontiers in neuroscience	2022	Identification of potential key circular RNAs related to cognitive impairment after chronic constriction injury of the sciatic nerve.		Chr17:84219927_84249246			chronic neuropathic pain	MONDO:0021667	neuralgia	down-regulated	RT-qPCR	Chr17:84219927_84249246 is down-regulated in hippocampus after CCI with cognitive dysfunction. The study includes it among validated circRNAs but provides no predicted miRNA MREs for this circRNA in the MRE table.	0.31
36061613	Frontiers in neuroscience	2022	Identification of potential key circular RNAs related to cognitive impairment after chronic constriction injury of the sciatic nerve.		Chr1:255706980_255774681			chronic neuropathic pain	MONDO:0021667	neuralgia	down-regulated	RT-qPCR	Chr1:255706980_255774681 is down-regulated in hippocampus of CCI rats with cognitive dysfunction. It is analyzed via predicted circRNA-miRNA-mRNA interactions and implicated in inflammation/apoptosis-associated mechanisms at a hypothesis level.	0.31
36062189	Oxidative medicine and cellular longevity	2022	Circ_000829 Plays an Anticancer Role in Renal Cell Carcinoma by Suppressing SRSF1-Mediated Alternative Splicing of SLC39A14.		circ_000829 / hsa_circ_000829			renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	down-regulated	RT-qPCR; Northern Blot; Microarray	"circ_000829 is down-regulated in renal cell carcinoma and acts as a tumor suppressor by inhibiting proliferation, promoting apoptosis, and reducing xenograft tumor growth. Mechanistically, it directly binds the RBP SRSF1 and suppresses SRSF1-driven alternative splicing of SLC39A14 toward the pro-proliferative SLC39A14B isoform."	0.7855
36062192	Oxidative medicine and cellular longevity	2022	"Hsa_circRNA_0008028 Deficiency Ameliorates High Glucose-Induced Proliferation, Calcification, and Autophagy of Vascular Smooth Muscle Cells via miR-182-5p/TRIB3 Axis."	hsa_circ_0008028	hsa_circRNA_0008028			diabetes-related vasculopathy	MONDO:0000960	diabetic peripheral angiopathy	up-regulated	RT-qPCR	"In high glucose-treated human VSMCs (a diabetes-related vasculopathy model), hsa_circRNA_0008028 is up-regulated and promotes proliferation, calcification, and autophagy. Mechanistically, it sponges miR-182-5p to relieve repression of TRIB3, thereby enhancing TRIB3 expression and VSMC dysfunction under HG conditions."	0.6908
36062271	Journal of clinical and translational hepatology	2022	CircTUBD1 Regulates Radiation-induced Liver Fibrosis Response via a circTUBD1/micro-203a-3p/Smad3 Positive Feedback Loop.	hsa_circ_0044897	circTUBD1	hsa_circ_TUBD1	TUBD1	radiation-induced liver fibrosis / RILF	MONDO:0043459	radiation-induced disorder	up-regulated	RT-qPCR; Microarray	"circTUBD1 is up-regulated after irradiation and promotes hepatic stellate cell activation and fibrogenic marker expression in RILF models. Mechanistically, it sponges miR-203a-3p to enhance SMAD3/TGF-beta signaling, while SMAD3 transcriptionally increases TUBD1/circTUBD1, forming a positive feedback loop; circTUBD1 knockdown alleviates irradiation-induced liver fibrosis in vivo."	0.7441
36064409	Cancer cell international	2022	circ_0061265 competitively binds to microRNA-885-3p to promote the development of gastric cancer by upregulating AURKA expression.	hsa_circ_0061265	circ_0061265			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	circ_0061265 is up-regulated in gastric cancer tissues/cells and promotes malignant phenotypes and cisplatin chemoresistance. It functions as a ceRNA by sponging miR-885-3p to increase AURKA expression.	0.7932
36064433	Experimental hematology & oncology	2022	CircRIC8B regulates the lipid metabolism of chronic lymphocytic leukemia through miR199b-5p/LPL axis.		circRIC8B	hsa_circ_RIC8B	RIC8B	chronic lymphocytic leukemia / CLL	MONDO:0003864	chronic lymphocytic leukemia/small lymphocytic lymphoma	up-regulated	RT-qPCR; RNA-seq	"circRIC8B is up-regulated in CLL and mainly localizes to the cytoplasm. It promotes CLL cell proliferation and lipid accumulation by sponging miR-199b-5p to increase LPL mRNA, and high circRIC8B is associated with poor prognosis."	0.8645
36065311	Journal of oncology	2022	"A Novel circRNA hsa_circRNA_002178 as a Diagnostic Marker in Hepatocellular Carcinoma Enhances Cell Proliferation, Invasion, and Tumor Growth by Stabilizing SRSF1 Expression."		hsa_circRNA_002178			Hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"In HCC, hsa_circRNA_002178 is up-regulated and promotes proliferation, migration, invasion, EMT, and xenograft tumor growth. Mechanistically, it binds the SRSF1 mRNA 3¡ä-UTR and increases SRSF1 mRNA stability and expression, and SRSF1 mediates the malignant phenotypes. High hsa_circRNA_002178 is linked to poorer overall survival and suggested as a diagnostic marker."	0.8322
36065412	Analytical cellular pathology (Amsterdam)	2022	circ_0052184 Promotes Colorectal Cancer Progression via Targeting miR-604/HOXA9 Axis.	hsa_circ_0052184	circ_0052184			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0052184 is up-regulated in colorectal cancer tissues and cell lines and promotes CRC cell proliferation, migration, and invasion. Mechanistically, it functions as a ceRNA by sponging miR-604 to relieve repression of HOXA9, forming a circ_0052184/miR-604/HOXA9 axis; it is proposed as a potential therapeutic target/diagnostic biomarker for CRC."	0.7032
36068004	Investigative and clinical urology	2022	Hsa_circ_0003221 facilitates the malignant development of bladder cancer cells via resulting in the upregulation of DHCR24 by targeting miR-892b.	hsa_circ_0003221	circ_0003221	hsa_circ_PTK2		bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circ_0003221 is upregulated in bladder cancer and promotes proliferation, migration/invasion, glycolysis, and xenograft tumor growth. Mechanistically, it sponges miR-892b to de-repress DHCR24, forming a circ_0003221/miR-892b/DHCR24 regulatory axis."	0.7548
36068586	Journal of hematology & oncology	2022	Hypoxia-induced exosomal circPDK1 promotes pancreatic cancer glycolysis via c-myc activation by modulating miR-628-3p/BPTF axis and degrading BIN1.	hsa_circ_0057104	circPDK1 / hsa_circRNA_102854	hsa_circ_PDK1	PDK1	pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; ISH; RNA-seq	"circPDK1 is upregulated in pancreatic cancer tissues and serum exosomes and correlates with poor prognosis. Under hypoxia, HIF1A increases circPDK1 via activating the PDK1 promoter. circPDK1 promotes proliferation, migration/metastasis and glycolysis by activating c-myc through a miR-628-3p/BPTF ceRNA axis and by scaffolding UBE2O-mediated ubiquitination/degradation of BIN1."	0.8995
36068644	Arthritis research & therapy	2022	CircPRKCH modulates extracellular matrix formation and metabolism by regulating the miR-145/HGF axis in osteoarthritis.	hsa_circ_0032131	CircPRKCH	hsa_circ_PRKCH	PRKCH	osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"CircPRKCH is up-regulated in OA cartilage and IL-1beta-treated human chondrocytes. It functions as a ceRNA that sponges miR-145, thereby increasing HGF expression and activating the HGF/c-MET axis, which promotes chondrocyte apoptosis and extracellular matrix degradation; circPRKCH knockdown alleviates OA-like cartilage damage in the mouse model."	0.5301
36071480	Journal of experimental & clinical cancer research : CR	2022	Hsa_circ_0000098 is a novel therapeutic target that promotes hepatocellular carcinoma development and resistance to doxorubicin.	hsa_circ_0000098	circ_0000098	hsa_circ_SLC30A7	SLC30A7	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0000098 is up-regulated in HCC and acts as an oncogenic circRNA. It mainly localizes in the cytoplasm and promotes HCC progression and doxorubicin resistance by sponging miR-383 to increase MCUR1, leading to higher ATP levels and P-gp-mediated drug efflux. Clinically, higher circ_0000098 associates with worse survival and shows diagnostic potential (ROC AUC 0.829)."	0.8824
36072601	Frontiers in immunology	2022	The landscape of circular RNA in preterm birth.		hsa-HIPK3_0001 / circHIPK3	hsa_circ_HIPK3	HIPK3	preterm birth / PTB	MONDO:0012511	preterm premature rupture of the membranes	up-regulated	RNA-seq	This study identified hsa-HIPK3_0001 (circHIPK3) as up-regulated in PTB (maternal plasma and cord blood) based on reanalysis of RNA-seq datasets. The authors propose it may contribute to PTB by promoting excessive immune-inflammatory responses.	0.1768
36072601	Frontiers in immunology	2022	The landscape of circular RNA in preterm birth.		hsa-SMARCA5_0005	hsa_circ_SMARCA5	SMARCA5	preterm birth / PTB	MONDO:0012511	preterm premature rupture of the membranes	down-regulated	RNA-seq	This study identified hsa-SMARCA5_0005 as strongly down-regulated in maternal plasma from PTB compared with term controls based on RNA-seq reanalysis. No specific downstream mechanism or function was experimentally validated for this circRNA in the paper.	0.1768
36072601	Frontiers in immunology	2022	The landscape of circular RNA in preterm birth.		hsa-SLTM_0001	hsa_circ_SLTM	SLTM	preterm birth / PTB	MONDO:0012511	preterm premature rupture of the membranes	up-regulated	RNA-seq	This study identified hsa-SLTM_0001 as up-regulated in maternal monocytes in PTB versus term controls from RNA-seq reanalysis. No specific downstream mechanism was experimentally validated for this circRNA in the paper.	0.1768
36072601	Frontiers in immunology	2022	The landscape of circular RNA in preterm birth.		hsa-LILRB1_0006	hsa_circ_LILRB1	LILRB1	preterm birth / PTB	MONDO:0012511	preterm premature rupture of the membranes	dysregulated	RNA-seq	"In maternal monocytes, hsa-LILRB1_0006 is implicated in PTB by being significantly correlated with its host gene LILRB1 and immune-inflammatory factors (IL1B, IL6). The paper does not report a validated direction of expression change for this specific circRNA in monocytes within the provided text."	0.1768
36072601	Frontiers in immunology	2022	The landscape of circular RNA in preterm birth.		hsa-CD63_0002	hsa_circ_CD63	CD63	preterm birth / PTB	MONDO:0012511	preterm premature rupture of the membranes	up-regulated	RNA-seq	This study identified hsa-CD63_0002 as up-regulated in chorion in PTB versus term controls from RNA-seq reanalysis. No circRNA-specific downstream mechanism for hsa-CD63_0002 was experimentally validated in this paper.	0.1768
36072601	Frontiers in immunology	2022	The landscape of circular RNA in preterm birth.		hsa-THBS1_0001	hsa_circ_THBS1	THBS1	preterm birth / PTB	MONDO:0012511	preterm premature rupture of the membranes	down-regulated	RNA-seq	"This study identified hsa-THBS1_0001 as down-regulated in chorion in PTB versus term controls from RNA-seq reanalysis. The discussion links THBS1 to inflammatory pathways (TGF-beta and NF-kappaB) and maternal-fetal interface disruption, but this mechanism is not directly validated for the circRNA."	0.1768
36072601	Frontiers in immunology	2022	The landscape of circular RNA in preterm birth.		hsa-IGSF1_0001	hsa_circ_IGSF1	IGSF1	preterm birth / PTB	MONDO:0012511	preterm premature rupture of the membranes	up-regulated	RNA-seq	This study identified hsa-IGSF1_0001 as up-regulated in placenta in PTB versus term controls from RNA-seq reanalysis. The paper does not report a circRNA-specific mechanism or function for hsa-IGSF1_0001.	0.1768
36072601	Frontiers in immunology	2022	The landscape of circular RNA in preterm birth.		hsa-GTF2IP4_0001	hsa_circ_GTF2IP4	GTF2IP4	preterm birth / PTB	MONDO:0012511	preterm premature rupture of the membranes	down-regulated	RNA-seq	This study identified hsa-GTF2IP4_0001 as down-regulated in placenta in PTB versus term controls from RNA-seq reanalysis. The paper does not report a circRNA-specific mechanism or function for hsa-GTF2IP4_0001.	0.1768
36072601	Frontiers in immunology	2022	The landscape of circular RNA in preterm birth.		hsa-PAPPA2_005	hsa_circ_PAPPA2	PAPPA2	preterm birth / PTB	MONDO:0012511	preterm premature rupture of the membranes	down-regulated	RNA-seq	"In placenta, hsa-PAPPA2_005 is reduced in PTB and shows a significant positive correlation with its host gene PAPPA2, which is described as important for placental development and function. This supports a potential placental functional relevance but is based on RNA-seq and correlation analyses only."	0.1768
36072601	Frontiers in immunology	2022	The landscape of circular RNA in preterm birth.		hsa-TMEM56-RWDD3_0004	hsa_circ_TMEM56-RWDD3	TMEM56-RWDD3	preterm birth / PTB	MONDO:0012511	preterm premature rupture of the membranes	up-regulated	RNA-seq	This study identified hsa-TMEM56-RWDD3_0004 as strongly up-regulated in cord blood in PTB compared with term controls based on RNA-seq reanalysis. No circRNA-specific mechanism was validated for this circRNA in the paper.	0.1768
36072623	Contrast media & molecular imaging	2022	Circ TYMP1 Inhibits Carcinogenesis and Cisplatin Resistance in Ovarian Cancer by Reducing Smad2/3 Phosphorylation via a MicroRNA-182A-3p/TGF1B Axis.		Circ TYMP1 / Circ_TYMP1	hsa_circ_TYMP1	TYMP1	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circ TYMP1 is up-regulated in ovarian carcinoma tissues and in cisplatin-resistant A2780-Res cells, and its silencing reduces proliferation/colony formation, invasion and cisplatin resistance while increasing apoptosis. Mechanistically, it acts as a ceRNA sponge for miR-182A-3p to derepress TGF1B and modulate Smad2/3 phosphorylation, contributing to tumor progression and drug resistance."	0.7941
36072902	Disease markers	2022	circFOXO3 Induced by KLF16 Modulates Clear Cell Renal Cell Carcinoma Growth and Natural Killer Cell Cytotoxic Activity through Sponging miR-29a-3p and miR-122-5p.	hsa_circ_0006404	circFOXO3 / circRNA forkhead box O3	hsa_circ_FOXO3	FOXO3	clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR	"In ccRCC, circFOXO3 is up-regulated and mainly localized in the cytoplasm. Functionally, circFOXO3 suppresses ccRCC cell proliferation, promotes apoptosis, and enhances NK cell-mediated cytotoxicity by sponging miR-29a-3p and miR-122-5p; its expression is transcriptionally upregulated by KLF16."	0.8344
36075896	Cell death & disease	2022	Circ-TRIO promotes TNBC progression by regulating the miR-432-5p/CCDC58 axis.	hsa_circ_0005260	circ-TRIO	hsa_circ_TRIO	TRIO	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	circ-TRIO is up-regulated in TNBC and promotes proliferation and metastasis-related behaviors (migration/invasion/EMT) in vitro and tumor growth and lung metastasis in vivo. It primarily acts in the cytoplasm as a ceRNA that sponges miR-432-5p to increase CCDC58 expression. High circ-TRIO expression is associated with recurrence and poorer DFS/OS in TNBC patients.	0.8906
36077296	International journal of molecular sciences	2022	RNA Sequencing Demonstrates That Circular RNA Regulates Avian Influenza Virus Replication in Human Cells.	hsa_circ_0005870		hsa_circ_SETD2	SETD2	avian influenza virus infection / AIV infection	MONDO:0018695	avian influenza	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005870 is induced by avian-origin influenza virus in human cells and shows antiviral activity: knockdown promotes, while overexpression suppresses AIV (H9N2) replication. It may act through a ceRNA mechanism by sponging specific miRNAs to influence host mRNA programs linked to the cell cycle."	0.6073
36077296	International journal of molecular sciences	2022	RNA Sequencing Demonstrates That Circular RNA Regulates Avian Influenza Virus Replication in Human Cells.	hsa_circ_0006104		hsa_circ_DCTN2	DCTN2	avian influenza virus infection / AIV infection	MONDO:0018695	avian influenza	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0006104 is up-regulated after avian influenza virus infection in A549 cells and exerts an antiviral effect (its knockdown enhances viral proliferation). It is predicted to act in a ceRNA network by interacting with miR-146a-5p/miR-146b-5p/miR-199a-3p to influence host mRNA regulation associated with infection responses.	0.6073
36077296	International journal of molecular sciences	2022	RNA Sequencing Demonstrates That Circular RNA Regulates Avian Influenza Virus Replication in Human Cells.		Novel_circ_0009609	hsa_circ_ARFGEF2	ARFGEF2	avian influenza virus infection / AIV infection	MONDO:0018695	avian influenza	up-regulated	RT-qPCR; RNA-seq	"Novel_circ_0009609 is up-regulated upon AIV infection in A549 cells and its knockdown increases viral proliferation, indicating an antiviral (host barrier) role. It is derived from ARFGEF2 exons and is linked by enrichment analyses to the endocytosis pathway, though its direct molecular mechanism was not experimentally resolved."	0.5512
36077296	International journal of molecular sciences	2022	RNA Sequencing Demonstrates That Circular RNA Regulates Avian Influenza Virus Replication in Human Cells.	hsa_circ_0060300		hsa_circ_SRC	SRC	avian influenza virus infection / AIV infection	MONDO:0018695	avian influenza	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0060300 is up-regulated during AIV infection and shows antiviral activity in functional assays (knockdown enhances H9N2 proliferation). It is suggested to act as a ceRNA by sponging has-miR-449c-5p to influence host mRNAs and is linked by enrichment to the endocytosis pathway.	0.5017
36077296	International journal of molecular sciences	2022	RNA Sequencing Demonstrates That Circular RNA Regulates Avian Influenza Virus Replication in Human Cells.	hsa_circ_0009365		hsa_circ_PRKCZ	PRKCZ	avian influenza virus infection / AIV infection	MONDO:0018695	avian influenza	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0009365 is up-regulated in AIV-infected A549 cells and functions as an antiviral factor: its knockdown enhances H9N2 proliferation, while it can reduce viral M1 vRNA transcription. The authors suggest it may also affect viral budding and vRNA stability, and it is linked by enrichment to endocytosis-related host processes."	0.6073
36077296	International journal of molecular sciences	2022	RNA Sequencing Demonstrates That Circular RNA Regulates Avian Influenza Virus Replication in Human Cells.	hsa_circ_0003428 		hsa_circ_POLI	POLI	avian influenza virus infection / AIV infection	MONDO:0018695	avian influenza	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0003428 is an AIV-induced circRNA in A549 cells with antiviral effects: silencing increases H9N2 proliferation. The study suggests it may act by modulating viral protein stability (M1) rather than M1 vRNA transcription, and its host gene links it to Fanconi anemia pathway enrichment."	0.6073
36077718	Cancers	2022	"Hsa_circ_0044301 Regulates Gastric Cancer Cell's Proliferation, Migration, and Invasion by Modulating the Hsa-miR-188-5p/DAXX Axis and MAPK Pathway."	hsa_circ_0044301	circRNA-0044301 / hsa_circRNA_0044301 			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"In gastric cancer, hsa_circ_0044301 is up-regulated and promotes malignant phenotypes (proliferation, migration, invasion) and tumor growth. Mechanistically, it functions as a ceRNA by sponging hsa-miR-188-5p to regulate DAXX and is linked to MAPK/ERK1/2 signaling, also modulating sensitivity to GDC-0994 and 5-FU. High expression is associated with poorer patient prognosis."	0.8634
36077848	Cancers	2022	Exploratory Circular RNA Profiling in Adrenocortical Tumors.		circPHC3 / hsa-PHC3_0006	hsa_circ_PHC3	PHC3	adrenocortical tumor	MONDO:0036591	adrenal cortex neoplasm	up-regulated	RT-qPCR; RNA-seq	"circPHC3 is significantly up-regulated in adrenocortical carcinoma and adenoma compared with normal adrenal cortex in FFPE clinical samples, confirmed by RT-qPCR after NGS discovery. The study explored a predicted miRNA-sponge role (let-7c-3p/miR-214/miR-195), but miRNA expression patterns were not fully consistent with the sponging hypothesis."	0.585
36081509	Frontiers in immunology	2022	Potential biomarkers for retinopathy of prematurity identified by circular RNA profiling in peripheral blood mononuclear cells.		hsa_circRNA_061346			retinopathy of prematurity / ROP	MONDO:0006952	retinopathy of prematurity	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_061346 is significantly up-regulated in PBMCs from treatment-requiring ROP infants versus premature controls, and shows diagnostic value for ROP with AUC ~0.92 in ROC analysis."	0.5047
36081509	Frontiers in immunology	2022	Potential biomarkers for retinopathy of prematurity identified by circular RNA profiling in peripheral blood mononuclear cells.		hsa_circRNA_092369	hsa_circ_TMEM56	TMEM56	retinopathy of prematurity / ROP	MONDO:0006952	retinopathy of prematurity	down-regulated	RT-qPCR; Microarray	hsa_circRNA_092369 (host gene TMEM56) is significantly down-regulated in PBMCs from treatment-requiring ROP infants versus controls and has diagnostic potential with AUC ~0.92 in ROC analysis.	0.5047
36081509	Frontiers in immunology	2022	Potential biomarkers for retinopathy of prematurity identified by circular RNA profiling in peripheral blood mononuclear cells.		hsa_circRNA_103554	hsa_circ_TFRC	TFRC	retinopathy of prematurity / ROP	MONDO:0006952	retinopathy of prematurity	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_103554 is significantly down-regulated in PBMCs from treatment-requiring ROP infants and serves as a potential diagnostic biomarker (AUC ~0.88). The paper notes TFRC as its host gene and discusses a possible link to angiogenesis/mitochondrial function via TFRC, but does not experimentally validate a specific mechanism for the circRNA."	0.5047
36081604	The Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale	2022	"Hsa_circ_0000479/Hsa-miR-149-5p/RIG-I, IL-6 Axis: A Potential Novel Pathway to Regulate Immune Response against COVID-19."	hsa_circ_0000479	circEPSTI1	hsa_circ_EPSTI1	EPSTI1	COVID-19 / coronavirus disease 2019 	MONDO:0100096	COVID-19	up-regulated	RT-qPCR	"In PBMCs from COVID-19 patients, hsa_circ_0000479 (circEPSTI1) is up-regulated and negatively correlated with hsa-miR-149-5p. The study proposes a ceRNA axis where hsa_circ_0000479 sponges hsa-miR-149-5p to associate with higher IL-6 and RIG-I expression, with pathway relevance to PI3K-AKT and STAT3 signaling."	0.348
36087384	Translational oncology	2022	Circular RNA 0010117 promotes aggressive glioblastoma behavior by regulating the miRNA-6779-5p/SPEN axis.	hsa_circ_0010117	circular RNA 0010117 / circ-0010117			glioblastoma / GBM	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR	"circ-0010117 is down-regulated in glioblastoma tissues. Functionally, circ-0010117 overexpression suppresses glioblastoma cell proliferation and invasion and increases apoptosis, and it inhibits tumor growth in a U251 xenograft model. Mechanistically, circ-0010117 binds miR-6779-5p and modulates the miR-6779-5p target SPEN, linking circ-0010117 to a miR-6779-5p/SPEN regulatory axis."	0.6287
36088391	Cell death & disease	2022	PLGA-microspheres-carried circGMCL1 protects against Crohn's colitis through alleviating NLRP3 inflammasome-induced pyroptosis by promoting autophagy.	hsa_circ_0055097	circGMCL1	hsa_circ_GMCL1	GMCL1	Crohn¡¯s disease / CD	MONDO:0005011	Crohn disease	down-regulated	RT-qPCR; Microarray	"circGMCL1 (hsa_circ_0055097), derived from GMCL1, is down-regulated in Crohn¡¯s disease colon tissues and correlates negatively with inflammatory indices. Functionally, circGMCL1 acts as a ceRNA to sponge miR-124-3p and upregulate ANXA7, promoting autophagy and suppressing NLRP3 inflammasome-mediated epithelial pyroptosis and intestinal barrier damage; PLGA-microsphere delivery of oe-circGMCL1 ameliorates colitis in IL-10 KO mice."	0.8487
36092318	Journal of gastrointestinal oncology	2022	Circ_0007099 upregulates GNG7 to function as a tumor inhibitor in gastric carcinoma by interacting with miR-425-3p.	hsa_circ_0007099	Circ_0007099	hsa_circ_ABHD2	ABHD2	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"circ_0007099 is down-regulated in gastric carcinoma and acts as a tumor suppressor. It sponges miR-425-3p to upregulate GNG7, thereby inhibiting proliferation, angiogenesis and glycolysis while promoting apoptosis, and it suppresses tumor growth in a cell line-derived xenograft model."	0.7856
36092323	Journal of gastrointestinal oncology	2022	CircMMP9 accelerates the progression of hepatocellular carcinoma through the miR-149/CCND2 axis.		circMMP9 / circular RNA MMP9	hsa_circ_MMP9	MMP9	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circMMP9 is up-regulated in HCC tissues and cell lines and its high expression is associated with poorer overall survival. Functionally, circMMP9 promotes proliferation, migration, invasion, cell-cycle progression and tumor growth, partly by sponging miR-149 to increase CCND2 expression (circMMP9/miR-149/CCND2 ceRNA axis)."	0.8201
36092343	Journal of gastrointestinal oncology	2022	Circular RNA ZFR promotes cell cycle arrest and apoptosis of colorectal cancer cells via the miR-147a/CACUL1 axis.		Circular RNA ZFR / circular ZFR	hsa_circ_ZFR	ZFR	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circZFR is up-regulated in colorectal cancer cell lines and functions as an oncogenic circRNA. It sponges miR-147a to relieve repression of CACUL1, thereby promoting proliferation and suppressing apoptosis while facilitating G1/S cell-cycle progression."	0.5627
36092909	Frontiers in genetics	2022	Knockdown of Circ_0037658 Alleviates IL-1beta-Induced Osteoarthritis Progression by Serving as a Sponge of miR-665 to Regulate ADAMTS5.	hsa_circ_0037658	circ_0037658			Osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circ_0037658 is up-regulated in OA cartilage and IL-1beta-treated human chondrocytes. Its knockdown alleviates IL-1beta-induced chondrocyte injury (reduced inflammation, apoptosis, and ECM degradation; increased proliferation) by sponging miR-665 to regulate ADAMTS5 (circ_0037658/miR-665/ADAMTS5 axis)."	0.7412
36098040	Journal of clinical laboratory analysis	2022	CircPTPRM accelerates malignancy of papillary thyroid cancer via miR-885-5p/DNMT3A axis.	hsa_circ_0007144	circPTPRM	hsa_circ_PTPRM	PTPRM	papillary thyroid cancer / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circPTPRM is up-regulated in papillary thyroid cancer and its high expression is associated with poor overall survival. Functionally, circPTPRM promotes PTC cell proliferation, migration, invasion and EMT while suppressing apoptosis, mainly by sponging miR-885-5p to upregulate DNMT3A (circPTPRM/miR-885-5p/DNMT3A axis)."	0.8169
36101791	International journal of chronic obstructive pulmonary disease	2022	Circ_0040929 Serves as Promising Biomarker and Potential Target for Chronic Obstructive Pulmonary Disease.	hsa_circ_0040929	circ_0040929	hsa_circ_ANKRD11	ANKRD11	chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR	"circ_0040929 is up-regulated in COPD patient serum and serum exosomes and in CSE-treated 16HBE cells. It promotes CSE-induced epithelial injury by functioning as a cytoplasmic miRNA sponge for miR-515-5p, thereby increasing IGFBP3 and enhancing apoptosis, inflammation, and airway remodeling while suppressing proliferation, suggesting biomarker and therapeutic-target potential in COPD."	0.8568
36104322	Cell death discovery	2022	Circular RNA circPGD contributes to gastric cancer progression via the sponging miR-16-5p/ABL2 axis and encodes a novel PGD-219aa protein.	hsa_circ_0009735	circPGD	hsa_circ_PGD	PGD	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circPGD (hsa_circ_0009735), derived from PGD, is up-regulated in gastric cancer tissues and cell lines and correlates with larger tumor size and lymph node metastasis. It promotes proliferation, migration/metastasis and EMT while inhibiting apoptosis by sponging miR-16-5p to de-repress ABL2 and activating SMAD2/3 and Hippo/YAP-related signaling. circPGD also encodes a tumor-promoting protein (PGD-219aa) that similarly enhances malignant phenotypes."	0.8072
36109749	Journal of orthopaedic surgery and research	2022	Circ_0136666 aggravates osteosarcoma development through mediating miR-1244/CEP55 axis.	hsa_circ_0136666	circ_0136666	hsa_circ_PRKDC	PRKDC	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ_0136666 is up-regulated in osteosarcoma and acts as an oncogenic circRNA. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-1244 to increase CEP55 expression, thereby promoting proliferation, migration/invasion, glycolysis, and tumor growth while inhibiting apoptosis."	0.8174
36109751	Reproductive biology and endocrinology : RB&E	2022	"Circ-CSNK1G1 promotes cell proliferation, migration, invasion and glycolysis metabolism during triple-negative breast cancer progression by modulating the miR-28-5p/LDHA pathway."	hsa_circ_0001955	circ-CSNK1G1 / circ_0001955	hsa_circ_CSNK1G1	CSNK1G1	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"circ-CSNK1G1 is up-regulated in TNBC tissues and cell lines and mainly localizes in the cytoplasm. It promotes TNBC malignant phenotypes (proliferation, migration, invasion, glycolysis) and tumor growth by sponging miR-28-5p to increase LDHA expression; higher circ-CSNK1G1 is associated with worse overall survival."	0.8069
36111016	Annals of translational medicine	2022	CircRNA_0050486 promotes cell apoptosis and inflammation by targeting miR-1270 in atherosclerosis.	hsa_circ_0050486	circRNA_0050486 / circ_0050486			atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR; Microarray	"circ_0050486 is up-regulated in oxLDL-induced THP-1 macrophages and promotes inflammatory cytokine production and apoptosis. Its knockdown reduces IL-6/TNF-alpha and apoptosis, at least partly by binding miR-1270 (and miR-145), with a proposed downstream miR-1270/NFIA link."	0.5804
36111133	Frontiers in molecular biosciences	2022	Systematic identification of aberrant non-coding RNAs and their mediated modules in rotator cuff tears.	hsa_circ_0000722				Rotator cuff tears / RCT	MONDO:0007028	rotator cuff syndrome	dysregulated	RNA-seq	"hsa_circ_0000722 was identified as a key circRNA in the largest dysregulated ceRNA module in RCT. It participates in ceRNA interactions by sponging hsa-miR-129-5p and hsa-miR-30c-5p to associate with mRNAs such as GPD2 and NCOA3, and the module is linked to vasculature development."	0.1768
36114310	Drug delivery and translational research	2023	Magnetically responsive nanoplatform targeting circRNA circ_0058051 inhibits hepatocellular carcinoma progression.	hsa_circ_0058051	circ_0058051 / circRNA_0058051	hsa_circ_BARD1	BARD1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	circ_0058051 (derived from BARD1) is up-regulated in HCC tissues and mainly localized in the cytoplasm. Its silencing via siRNA (delivered by a magnetic SPION-based nanoplatform) suppresses HCC cell proliferation/colony formation and migration in vitro and inhibits xenograft tumor growth in vivo; high expression is associated with worse patient prognosis.	0.8079
36114444	BMC neuroscience	2022	A circular RNA derived from GLIS3 accelerates the proliferation of glioblastoma cells through competitively binding with miR-449c-5p to upregulate CAPG and GLIS3.	hsa_circ_0005890	CircGLIS3 / circ_0005890	hsa_circ_GLIS3	GLIS3	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR	"circGLIS3 (circ_0005890), derived from GLIS3, is up-regulated in glioblastoma cell lines and promotes proliferation while inhibiting apoptosis. Mechanistically, circGLIS3 mainly localizes to the cytoplasm and acts as a ceRNA by sponging miR-449c-5p, thereby upregulating CAPG and GLIS3."	0.809
36115854	Cell death & disease	2022	CircSEMA4B inhibits the progression of breast cancer by encoding a novel protein SEMA4B-211aa and regulating AKT phosphorylation.	hsa_circ_0000650	circSEMA4B	hsa_circ_SEMA4B	SEMA4B	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	"circSEMA4B is down-regulated in breast cancer and functions as a tumor suppressor. It inhibits PI3K/AKT signaling by sponging miR-330-3p to upregulate PDCD4 (reducing AKT Ser473 phosphorylation) and also serves as a protein-coding circRNA that produces SEMA4B-211aa, which contributes to pathway suppression."	0.8752
36117915	Frontiers in molecular neuroscience	2022	"Transcriptome analysis of microRNAs, circRNAs, and mRNAs in the dorsal root ganglia of paclitaxel-induced mice with neuropathic pain."	mmu_circ_0009357		mmu_circ_Prnp	Prnp	neuropathic pain	MONDO:0021667	neuralgia	up-regulated	RT-qPCR; RNA-seq	"mmu_circ_0009357 is significantly up-regulated in DRG tissue of paclitaxel-treated C57BL/6 mice with neuropathic pain. The study predicts it may interact with mmu-miR-7024-5p, suggesting a potential miRNA-sponge (ceRNA-like) role, but no downstream targets or functional assays were performed."	0.3684
36117915	Frontiers in molecular neuroscience	2022	"Transcriptome analysis of microRNAs, circRNAs, and mRNAs in the dorsal root ganglia of paclitaxel-induced mice with neuropathic pain."	mmu_circ_0013069		mmu_circ_Ptms	Ptms	neuropathic pain	MONDO:0021667	neuralgia	up-regulated	RT-qPCR; RNA-seq	"mmu_circ_0013069 (host gene Ptms) is significantly up-regulated in DRG tissue in paclitaxel-induced neuropathic pain mice. The study predicts multiple interacting miRNAs (e.g., mmu-miR-326-3p and mmu-miR-22-5p), implying a potential miRNA-sponge mechanism, but provides no functional downstream validation."	0.3684
36117915	Frontiers in molecular neuroscience	2022	"Transcriptome analysis of microRNAs, circRNAs, and mRNAs in the dorsal root ganglia of paclitaxel-induced mice with neuropathic pain."	mmu_circ_0006031		mmu_circ_Mll2	Mll2	neuropathic pain	MONDO:0021667	neuralgia	up-regulated	RT-qPCR; RNA-seq	"mmu_circ_0006031 (host gene Mll2) is significantly up-regulated in DRGs after paclitaxel treatment in a mouse neuropathic pain model. The study predicts it may bind several PTX-dysregulated miRNAs (including mmu-miR-339-5p), consistent with a potential miRNA-sponge regulatory role, but does not establish downstream targets or functional effects."	0.3684
36117915	Frontiers in molecular neuroscience	2022	"Transcriptome analysis of microRNAs, circRNAs, and mRNAs in the dorsal root ganglia of paclitaxel-induced mice with neuropathic pain."	mmu_circ_0001817				neuropathic pain	MONDO:0021667	neuralgia	up-regulated	RT-qPCR; RNA-seq	"mmu_circ_0001817 is significantly up-regulated in mouse DRGs after paclitaxel treatment. Bioinformatic prediction suggests it may bind mmu-let-7d-3p, indicating a possible circRNA/miRNA interaction relevant to PTX-induced neuropathic pain, but no downstream pathway or function was experimentally tested."	0.3684
36118796	"Diabetes, metabolic syndrome and obesity : targets and therapy"	2022	Peripheral Blood circRNA Microarray Profiling Identities hsa_circ_0001831 and hsa_circ_0000867 as Two Novel circRNA Biomarkers for Early Type 2 Diabetic Nephropathy.	hsa_circ_0001831		hsa_circ_SCRIB	SCRIB	diabetic nephropathy / DN	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001831 is significantly up-regulated in peripheral blood of ET2DN patients versus T2DM and controls and shows strong diagnostic performance by ROC analysis. The study predicts a circRNA_miRNA_mRNA interaction network (including hsa-miR-3151-5p, hsa-miR-6791-5p, hsa-miR-939-5p, hsa-miR-637, hsa-miR-7974) but does not experimentally validate downstream targets."	0.5963
36118796	"Diabetes, metabolic syndrome and obesity : targets and therapy"	2022	Peripheral Blood circRNA Microarray Profiling Identities hsa_circ_0001831 and hsa_circ_0000867 as Two Novel circRNA Biomarkers for Early Type 2 Diabetic Nephropathy.	hsa_circ_0000867		hsa_circ_OAZ1	OAZ1	diabetic nephropathy / DN	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000867 is up-regulated in peripheral blood of ET2DN patients versus T2DM and controls and has strong diagnostic value by ROC analysis. The study predicts that hsa_circ_0000867 may interact with has-miR-146a-3p and has-miR-877-3p within a circRNA_miRNA_mRNA network, but functional mechanisms are not experimentally validated."	0.5963
36119459	Mediterranean journal of hematology and infectious diseases	2022	CircRNA CircEHBP1 Regulates the Maturation of MiR-129 to Increase the Chemoresistance of Cancer Cells to Adriamycin in Acute Myeloid Leukaemia.		circEHBP1	hsa_circ_EHBP1	EHBP1	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"circEHBP1 is up-regulated in AML (especially in ADR-resistant cases) and promotes adriamycin chemoresistance by inhibiting ADR-induced apoptosis. Mechanistically, it binds premature miR-129 (present in both nucleus and cytoplasm) and suppresses miR-129 maturation, reducing mature miR-129 activity."	0.6676
36127319	Cell death & disease	2022	N6-methyladenosine modification of circ_0003215 suppresses the pentose phosphate pathway and malignancy of colorectal cancer through the miR-663b/DLG4/G6PD axis.	hsa_circ_0003215	circ_0003215	hsa_circ_MYO9B	MYO9B	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq; Microarray	"circ_0003215 is down-regulated in colorectal cancer and functions as a tumor suppressor. It is degraded in an m6A-dependent manner via the m6A reader YTHDF2, and inhibits malignancy and PPP metabolism by sponging miR-663b to increase DLG4, which promotes K48-linked ubiquitination of G6PD."	0.8657
36129153	Oncology reports	2022	"Dysregulated circular RNAs are closely linked to multiple myeloma prognosis, with circ_0026652 predicting bortezomib_based treatment response and survival via the microRNA_608_mediated Wnt/beta_catenin pathway."	hsa_circ_0026652	circ_0026652			multiple myeloma / MM	MONDO:0009693	plasma cell myeloma	down-regulated	RT-qPCR; Microarray	"In multiple myeloma, circ_0026652 is linked to inferior bortezomib-based treatment response and poorer survival. Functionally, circ_0026652 knockdown increases bortezomib chemosensitivity and apoptosis in U266 and RPMI-8226 cells, at least partly through a miR-608-mediated Wnt/beta-catenin (WNT3A/beta-catenin) signaling mechanism."	0.7325
36129153	Oncology reports	2022	"Dysregulated circular RNAs are closely linked to multiple myeloma prognosis, with circ_0026652 predicting bortezomib_based treatment response and survival via the microRNA_608_mediated Wnt/beta_catenin pathway."	hsa_circ_0068708	circ_0068708			multiple myeloma / MM	MONDO:0009693	plasma cell myeloma	down-regulated	RT-qPCR; Microarray	circ_0068708 is downregulated in CR versus NR MM cases and its expression is associated with prognosis; higher circ_0068708 predicts shorter PFS in this cohort.	0.5963
36129153	Oncology reports	2022	"Dysregulated circular RNAs are closely linked to multiple myeloma prognosis, with circ_0026652 predicting bortezomib_based treatment response and survival via the microRNA_608_mediated Wnt/beta_catenin pathway."	hsa_circ_0088128	circ_0088128			multiple myeloma / MM	MONDO:0009693	plasma cell myeloma	down-regulated	RT-qPCR; Microarray	circ_0088128 is downregulated in CR versus NR MM cases and is associated with treatment response in this cohort; survival association was not observed.	0.5135
36129153	Oncology reports	2022	"Dysregulated circular RNAs are closely linked to multiple myeloma prognosis, with circ_0026652 predicting bortezomib_based treatment response and survival via the microRNA_608_mediated Wnt/beta_catenin pathway."	hsa_circ_0001566	circ_0001566	hsa_circ_TEP1	TEP1	multiple myeloma / MM	MONDO:0009693	plasma cell myeloma	down-regulated	RT-qPCR; Microarray	"circ_0001566 is downregulated in CR versus NR MM cases (and in ORR versus non-ORR). Clinically, higher circ_0001566 expression predicts worse overall survival in this cohort."	0.5963
36129153	Oncology reports	2022	"Dysregulated circular RNAs are closely linked to multiple myeloma prognosis, with circ_0026652 predicting bortezomib_based treatment response and survival via the microRNA_608_mediated Wnt/beta_catenin pathway."	hsa_circ_0031113	circ_0031113	hsa_circ_TEP1	TEP1	multiple myeloma / MM	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR; Microarray	circ_0031113 is upregulated in CR versus NR MM cases and is associated with better progression-free survival when highly expressed. The paper discusses a potential circ_0031113_TEP1 (host gene) relationship as a possible explanation for its favorable association.	0.5963
36129153	Oncology reports	2022	"Dysregulated circular RNAs are closely linked to multiple myeloma prognosis, with circ_0026652 predicting bortezomib_based treatment response and survival via the microRNA_608_mediated Wnt/beta_catenin pathway."	hsa_circ_0083587	circ_0083587			multiple myeloma / MM	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR; Microarray	"circ_0083587 is upregulated in CR versus NR MM cases and associated with treatment response. The study discusses a potential ceRNA-like mechanism where circ_0083587 sponges miR-6875-5p, potentially affecting survival/proliferation-related programs."	0.5135
36129153	Oncology reports	2022	"Dysregulated circular RNAs are closely linked to multiple myeloma prognosis, with circ_0026652 predicting bortezomib_based treatment response and survival via the microRNA_608_mediated Wnt/beta_catenin pathway."	hsa_circ_0005552	circ_0005552			multiple myeloma / MM	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR; Microarray	circ_0005552 is upregulated in CR versus NR MM cases and associated with treatment response. Higher circ_0005552 expression predicts longer PFS in this cohort.	0.5963
36129153	Oncology reports	2022	"Dysregulated circular RNAs are closely linked to multiple myeloma prognosis, with circ_0026652 predicting bortezomib_based treatment response and survival via the microRNA_608_mediated Wnt/beta_catenin pathway."	hsa_circ_0007171	circ_0007171			multiple myeloma / MM	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR; Microarray	circ_0007171 is upregulated in CR versus NR MM cases and associated with treatment response in this cohort; no survival association was observed.	0.5135
36131287	Journal of experimental & clinical cancer research : CR	2022	CircPAK1 promotes the progression of hepatocellular carcinoma via modulation of YAP nucleus localization by interacting with 14-3-3zeta.		circPAK1	hsa_circ_PAK1	PAK1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circPAK1 is upregulated in HCC tissues/cell lines and promotes proliferation, migration/invasion, metastasis and angiogenesis while inhibiting apoptosis. It binds 14_3-3zeta competitively with YAP, promoting YAP nuclear localization and Hippo pathway inactivation. circPAK1 is enriched in exosomes from lenvatinib-resistant cells and can transfer resistance to recipient HCC cells."	0.8949
36132143	Frontiers in oncology	2022	Transcriptome sequencing of hepatocellular carcinoma uncovers multiple types of dysregulated ncRNAs.	hsa_circ_0000268	cZRANB1	hsa_circ_ZRANB1	ZRANB1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RNA-seq	"cZRANB1 (hsa_circ_0000268) is up-regulated in HCC tumor tissues and is also higher in HCC patient blood exosomes. The study predicts that it may act as a ceRNA/miRNA sponge (e.g., for let-7 family and miR-125b-5p/miR-195-5p/miR-497-5p) to increase HMGA1 expression and thereby promote tumor invasion."	0.1768
36132143	Frontiers in oncology	2022	Transcriptome sequencing of hepatocellular carcinoma uncovers multiple types of dysregulated ncRNAs.	hsa_circ_0007099				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RNA-seq	hsa_circ_0007099 is reported as down-regulated in the HCC S2 subclass in this RNA-seq based analysis. The study does not provide mechanistic validation; it only suggests a possible inverse association with the MYC and PI3K/Akt activation features of S2.	0.1768
36135094	"Current oncology (Toronto, Ont.)"	2022	The Down-Regulation of Circ_0059707 in Acute Myeloid Leukemia Promotes Cell Growth and Inhibits Apoptosis by Regulating miR-1287-5p.	hsa_circ_0059707	circ_0059707	hsa_circ_ID1	ID1	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	down-regulated	RT-qPCR	"circ_0059707 (derived from ID1) is down-regulated in AML and acts as a tumor-suppressive circRNA: its overexpression inhibits leukemia cell growth, promotes apoptosis, and suppresses K562 xenograft tumor growth. Mechanistically, it is linked to miR-1287-5p (predicted binding site; miR-1287-5p increases upon circ_0059707 overexpression)."	0.6767
36138395	Cellular & molecular biology letters	2022	circ_0086296 induced atherosclerotic lesions via the IFIT1/STAT1 feedback loop by sponging miR-576-3p.	hsa_circ_0086296	circ_0086296 / circ-UHRF2	hsa_circ_UHRF2	UHRF2	atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR; ISH; Microarray	"circ_0086296 is up-regulated in atherosclerosis-related samples and promotes endothelial injury and atherosclerotic lesion formation. Mechanistically, it sponges miR-576-3p to increase IFIT1 and STAT1, while STAT1 transcriptionally enhances circ_0086296, forming a positive feedback loop; EIF4A3 promotes its biogenesis and it is enriched in patient serum EVs/exosomes."	0.8861
36138395	Cellular & molecular biology letters	2022	circ_0086296 induced atherosclerotic lesions via the IFIT1/STAT1 feedback loop by sponging miR-576-3p.	mmu_circ_0000945	circ_0086296 / circ-UHRF2	mmu_circ_UHRF2	UHRF2	atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR; ISH; Microarray	"circ_0086296 is up-regulated in atherosclerosis-related samples and promotes endothelial injury and atherosclerotic lesion formation. Mechanistically, it sponges miR-576-3p to increase IFIT1 and STAT1, while STAT1 transcriptionally enhances circ_0086296, forming a positive feedback loop; EIF4A3 promotes its biogenesis and it is enriched in patient serum EVs/exosomes."	0.8861
36138764	Biology	2022	Deciphering the CircRNA-Regulated Response of Western Honey Bee (Apis mellifera) Workers to Microsporidian Invasion.		novel_circ_000705			nosemosis	MONDO:0005846	microsporidiosis	unknown	RT-qPCR; RNA-seq	"novel_circ_000705 is a DEcircRNA in A. m. ligustica worker midguts under V. ceranae infection and was among the circRNAs selected for RT-qPCR verification, supporting its infection-associated differential expression."	0.4625
36138764	Biology	2022	Deciphering the CircRNA-Regulated Response of Western Honey Bee (Apis mellifera) Workers to Microsporidian Invasion.		novel_circ_001195			nosemosis	MONDO:0005846	microsporidiosis	unknown	RT-qPCR; RNA-seq	"novel_circ_001195 is a DEcircRNA in A. m. ligustica worker midguts under V. ceranae infection and was selected for RT-qPCR verification, supporting its infection-associated differential expression."	0.4625
36138764	Biology	2022	Deciphering the CircRNA-Regulated Response of Western Honey Bee (Apis mellifera) Workers to Microsporidian Invasion.		novel_circ_011173			nosemosis	MONDO:0005846	microsporidiosis	unknown	RT-qPCR; RNA-seq	"novel_circ_011173 is a DEcircRNA in A. m. ligustica worker midguts under V. ceranae infection and was selected for RT-qPCR verification, supporting its infection-associated differential expression."	0.4625
36138764	Biology	2022	Deciphering the CircRNA-Regulated Response of Western Honey Bee (Apis mellifera) Workers to Microsporidian Invasion.		novel_circ_006925		ncbi_412810	nosemosis	MONDO:0005846	microsporidiosis	unknown	RT-qPCR; RNA-seq	novel_circ_006925 is a DEcircRNA validated by RT-qPCR; it is discussed as potentially influencing host energy metabolism during V. ceranae infection via its source gene annotated to oxidative phosphorylation.	0.4625
36138764	Biology	2022	Deciphering the CircRNA-Regulated Response of Western Honey Bee (Apis mellifera) Workers to Microsporidian Invasion.		novel_circ_012352			nosemosis	MONDO:0005846	microsporidiosis	unknown	RT-qPCR; RNA-seq	novel_circ_012352 is a DEcircRNA validated by RT-qPCR and was included among DEcircRNAs mapped to the FoxO signaling pathway within immune-related ceRNA networks during V. ceranae infection.	0.4997
36138764	Biology	2022	Deciphering the CircRNA-Regulated Response of Western Honey Bee (Apis mellifera) Workers to Microsporidian Invasion.		novel_circ_012316			nosemosis	MONDO:0005846	microsporidiosis	unknown	RT-qPCR; RNA-seq	"novel_circ_012316 is a DEcircRNA validated by RT-qPCR and appears in immune-associated ceRNA networks, including the FoxO signaling pathway, during V. ceranae infection."	0.4997
36138764	Biology	2022	Deciphering the CircRNA-Regulated Response of Western Honey Bee (Apis mellifera) Workers to Microsporidian Invasion.		novel_circ_007686			nosemosis	MONDO:0005846	microsporidiosis	unknown	RT-qPCR; RNA-seq	"novel_circ_007686 is a DEcircRNA in A. m. ligustica worker midguts under V. ceranae infection and was selected for RT-qPCR verification, supporting its infection-associated differential expression."	0.4625
36138764	Biology	2022	Deciphering the CircRNA-Regulated Response of Western Honey Bee (Apis mellifera) Workers to Microsporidian Invasion.		novel_circ_011500			nosemosis	MONDO:0005846	microsporidiosis	unknown	RT-qPCR; RNA-seq	"novel_circ_011500 is a DEcircRNA in A. m. ligustica worker midguts under V. ceranae infection and was selected for RT-qPCR verification, supporting its infection-associated differential expression."	0.4625
36138764	Biology	2022	Deciphering the CircRNA-Regulated Response of Western Honey Bee (Apis mellifera) Workers to Microsporidian Invasion.		novel_circ_012410			nosemosis	MONDO:0005846	microsporidiosis	down-regulated	RNA-seq	"novel_circ_012410 is strongly down-regulated in infected midguts (7 dpi) and is proposed to regulate the PGRP-S2 gene, potentially contributing to recognition of V. ceranae infection; it was not among the RT-qPCR-validated circRNAs."	0.4535
36138764	Biology	2022	Deciphering the CircRNA-Regulated Response of Western Honey Bee (Apis mellifera) Workers to Microsporidian Invasion.		novel_circ_014246			nosemosis	MONDO:0005846	microsporidiosis	up-regulated	RNA-seq	novel_circ_014246 is up-regulated at 7 dpi post infection and is discussed as potentially modulating cell cycle and apoptosis-related gene expression in the infected midgut response to V. ceranae.	0.4128
36138942	Brain sciences	2022	Transcriptome Sequencing Reveal That Rno-Rsf1_0012 Participates in Levodopa-Induced Dyskinesia in Parkinson's Disease Rats via Binding to Rno-mir-298-5p.		rno-Rsf1_0012	rno_circ_Rsf1	Rsf1	Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	up-regulated	RT-qPCR; RNA-seq	"rno-Rsf1_0012 is up-regulated in the striatum of LID rats and is mainly localized in the cytoplasm. It functions as a ceRNA by sponging rno-miR-298-5p, which is associated with increased expression of target genes PCP4 and TBP, suggesting a role in LID occurrence/development."	0.508
36139684	Cancers	2022	Circular RNA hsa_circ_0062682 Binds to YBX1 and Promotes Oncogenesis in Hepatocellular Carcinoma.	hsa_circ_0062682		hsa_circ_TPST2	TPST2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0062682 is up-regulated in HCC and promotes oncogenic phenotypes in HCC cell models, including proliferation, colony formation, migration and invasion, with cell-type-specific effects on migration and sorafenib response. Mechanistically, it binds multiple RBPs, with YBX1 validated as a key binding partner, and its perturbation induces broad transcriptomic and pathway changes linked to oncogenesis."	0.7736
36147545	Journal of bone oncology	2022	Circular RNA circDOCK1 contributes to osteosarcoma progression by acting as a ceRNA for miR-936 to regulate LEF1.	hsa_circ_0020378	circDOCK1	hsa_circ_DOCK1	DOCK1	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circDOCK1 is up-regulated in osteosarcoma tissues and cell lines and mainly localizes to the cytoplasm. It promotes osteosarcoma malignant behaviors (proliferation, migration, invasion, angiogenesis and tumor growth) by acting as a ceRNA that sponges miR-936, thereby relieving miR-936-mediated repression of LEF1."	0.8039
36148577	Gut and liver	2023	Hsa_circ_0003602 Contributes to the Progression of Colorectal Cancer by Mediating the miR-149-5p/SLC38A1 Axis.	hsa_circ_0003602	circ_0003602 / circSMARCC1	hsa_circ_SMARCC1	SMARCC1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"hsa_circ_0003602 (circ_0003602/circSMARCC1) is upregulated in colorectal cancer and functions as an oncogenic circRNA. It sponges miR-149-5p to increase SLC38A1, promoting malignant phenotypes including proliferation/viability, migration/invasion, angiogenesis, glutaminolysis, and tumor growth while inhibiting apoptosis; high expression indicates poorer overall survival."	0.7892
36148757	Thoracic cancer	2022	"Exosome-delivered circSATB2 targets the miR-330-5p/PEAK1 axis to regulate proliferation, migration and invasion of lung cancer cells."	hsa_circ_0008928	circSATB2 / circ_SATB2	hsa_circ_SATB2	SATB2	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circSATB2 is up-regulated in lung-cancer-cell-derived exosomes and can be transferred into recipient lung cancer cells. Exosomal circSATB2 promotes proliferation, migration, invasion, and in vivo tumor growth by sponging miR-330-5p to increase PEAK1 expression."	0.6001
36153605	Journal of orthopaedic surgery and research	2022	Circ_0051079 functions as an oncogenic regulator in osteosarcoma by leading to MAFB expression upregulation by competitively interacting with miR-1286.	hsa_circ_0051079	circ_0051079 / cic_0051079			osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ_0051079 is upregulated in osteosarcoma and mainly localized in the cytoplasm. It promotes malignant phenotypes (proliferation, migration/invasion, EMT) and tumor growth by sponging miR-1286, thereby relieving miR-1286-mediated repression of MAFB and increasing MAFB expression."	0.8427
36156852	The Kaohsiung journal of medical sciences	2022	CircPTK2 accelerates tumorigenesis of colorectal cancer by upregulating AKT2 expression via miR-506-3p.	hsa_circ_0005273	circPTK2 / Circular RNA PTK2	hsa_circ_PTK2	PTK2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circPTK2 is up-regulated in colorectal cancer cell lines and promotes malignant phenotypes (proliferation, migration, invasion). Mechanistically, it sponges miR-506-3p to relieve repression of AKT2, forming a circPTK2/miR-506-3p/AKT2 ceRNA axis that drives CRC progression."	0.5301
36159591	Molecular therapy. Nucleic acids	2022	Circular RNA circSFMBT2 downregulation by HBx promotes hepatocellular carcinoma metastasis via the miR-665/TIMP3 axis.	hsa_circ_0000211	circSFMBT2	hsa_circ_SFMBT2	SFMBT2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; ISH; RNA-seq	"In hepatocellular carcinoma, circSFMBT2 is down-regulated (including in HBx-overexpressing contexts) and functions as a tumor suppressor by inhibiting migration/invasion and metastasis. Mechanistically, it sponges miR-665 to de-repress TIMP3, while HBx suppresses circSFMBT2 formation via DHX9-mediated binding to flanking Alu elements. Low circSFMBT2 expression is associated with vascular invasion and poorer OS/DFS."	0.8876
36159776	Molecular therapy oncolytics	2022	The pivotal regulatory factor circBRWD1 inhibits arsenic exposure-induced lung cancer occurrence by binding mRNA and regulating its stability.		circBRWD1	hsa_circ_BRWD1		lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR; RNA-seq	"circBRWD1 is down-regulated in arsenic-exposed malignantly transformed bronchial epithelial cells and in multiple lung cancer cell lines. Functionally, circBRWD1 suppresses proliferation and cell-cycle progression and promotes apoptosis. Mechanistically, it directly binds c-JUN/c-MYC/CDK6 mRNAs and decreases their stability, reducing oncogenic mRNA/protein expression and thereby inhibiting arsenic-induced lung carcinogenesis."	0.7958
36161346	Journal of clinical laboratory analysis	2022	Hsa_circ_0002082 up-regulates Centromere Protein F via abolishing miR-508-3p to promote breast cancer progression.	hsa_circ_0002082	circ_MALAT1	hsa_circ_MALAT1	MALAT1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"In breast cancer, hsa_circ_0002082 is up-regulated in tumors and patient plasma and mainly localizes to the cytoplasm. It promotes malignant phenotypes (proliferation, migration/invasion, metastasis and EMT) and inhibits apoptosis by sponging miR-508-3p to up-regulate CENPF; silencing hsa_circ_0002082 suppresses xenograft growth."	0.7791
36161608	Turkish journal of medical sciences	2022	Circular RNA circPRMT5 is upregulated in breast cancer and is required for cell proliferation and migration.	hsa_circ_0031242	circPRMT5	hsa_circ_PRMT5	PRMT5	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circPRMT5 is upregulated in breast cancer tissues, patient serum, and breast cancer cell lines. Functionally, circPRMT5 promotes proliferation, migration and invasion in vitro, and higher circPRMT5 expression is associated with worse patient survival and diagnostic potential by ROC analysis."	0.6579
36164444	BioMed research international	2022	circZC3HAV1 Regulates TBC1D9 to Affect the Biological Behavior of Colorectal Cancer Cells.	hsa_circ_0082628	circ_0082628 / circZC3HAV1	hsa_circ_ZC3HAV1	ZC3HAV1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"circZC3HAV1 is down-regulated in colorectal cancer cells and suppresses migration and invasion. Mechanistically, it functions as a ceRNA that sponges miR-146b-3p, thereby upregulating TBC1D9 to restrain malignant behaviors."	0.7909
36164726	Journal of clinical laboratory analysis	2022	Circular RNA hsa_circ_0018189 drives non-small cell lung cancer growth by sequestering miR-656-3p and enhancing xCT expression.	hsa_circ_0018189	circCUL2	hsa_circ_CUL2	CUL2	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0018189 (circCUL2) is up-regulated in NSCLC tissues and cell lines and promotes proliferation, migration/invasion, EMT-like changes, glutamine metabolism, and xenograft tumor growth. Mechanistically, it acts as a ceRNA by sponging miR-656-3p, thereby increasing xCT (SLC7A11) expression."	0.8327
36166140	Genes & genomics	2022	Circular RNA expression profile of systemic lupus erythematosus and its clinical significance as a potential novel biomarker.	hsa_circ_0006689		hsa_circ_SLC15A4	SLC15A4	systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0006689 is down-regulated in PBMCs from SLE patients and its expression correlates with SLEDAI disease activity. It shows diagnostic utility by ROC analysis and improves diagnostic sensitivity when combined with anti-dsDNA or anti-Sm antibodies, supporting its potential as an SLE diagnostic/prognostic biomarker."	0.5963
36166140	Genes & genomics	2022	Circular RNA expression profile of systemic lupus erythematosus and its clinical significance as a potential novel biomarker.	hsa_circ_0042519				systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0042519 is up-regulated in PBMCs from SLE patients versus healthy controls by RT-qPCR validation, but the study does not report a mechanism, pathway, or clinical performance analysis specific to this circRNA."	0.5135
36166140	Genes & genomics	2022	Circular RNA expression profile of systemic lupus erythematosus and its clinical significance as a potential novel biomarker.	hsa_circ_0008647				systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0008647 is up-regulated in PBMCs from SLE patients versus healthy controls by RT-qPCR validation, but the paper does not provide additional mechanistic or clinical-biomarker analyses specific to this circRNA."	0.5135
36167680	Human genomics	2022	Circular RNA hsa_circ_0000915 promotes propranolol resistance of hemangioma stem cells in infantile haemangiomas.	hsa_circ_0000915	Circ_0000915	hsa_circ_FKBP8	FKBP8	infantile haemangiomas / IH	MONDO:0009331	isolated hemihyperplasia	up-regulated	RT-qPCR	"hsa_circ_0000915 (Circ_0000915), derived from FKBP8, is up-regulated in infantile haemangioma tissues and is higher in propranolol-resistant cases. It promotes propranolol resistance in HemSCs by being transcriptionally activated via IL-6/STAT3 and acting as a cytoplasmic miR-890 sponge to de-repress RNF187."	0.7322
36167685	Cell death & disease	2022	Circ_CEA promotes the interaction between the p53 and cyclin-dependent kinases 1 as a scaffold to inhibit the apoptosis of gastric cancer.	hsa_circ_0051240	circ_CEA	hsa_circ_CEACAM5		gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"circ_CEA (hsa_circ_0051240), derived from the CEA/CEACAM5 gene, is up-regulated in gastric cancer tissues and cell lines and acts as an oncogenic circRNA. It binds p53 and CDK1 as a scaffold to enhance CDK1-driven p53 Ser315 phosphorylation, reducing p53 nuclear retention and transcriptional activation of pro-apoptotic genes, thereby inhibiting stress/chemo-induced apoptosis and promoting tumor growth and metastasis."	0.8772
36168415	Experimental and therapeutic medicine	2022	Functional prediction and profiling of exosomal circRNAs derived from seminal plasma for the diagnosis and treatment of oligoasthenospermia.		chr3:132050491-132051188+			oligoasthenospermia / OAZ	MONDO:0850098	oligoasthenoteratozoospermia	dysregulated	RT-qPCR; RNA-seq	"This novel exosomal circRNA (chr3:132050491-132051188+) is differentially expressed in seminal plasma exosomes from OAZ patients versus healthy controls and was among seven circRNAs validated by RT-qPCR. A predicted circRNA_miRNA_mRNA network suggests it may act through a ceRNA/miRNA-sponge mechanism, with ACPP measured as a putative target gene."	0.4032
36168415	Experimental and therapeutic medicine	2022	Functional prediction and profiling of exosomal circRNAs derived from seminal plasma for the diagnosis and treatment of oligoasthenospermia.	hsa_circ_0005584				oligoasthenospermia / OAZ	MONDO:0850098	oligoasthenoteratozoospermia	dysregulated	RT-qPCR; RNA-seq	"Exosomal hsa_circ_0005584 is differentially expressed in seminal plasma exosomes from OAZ patients and was validated by RT-qPCR. Bioinformatic predictions place it in a circRNA_miRNA_mRNA regulatory network (putative miRNA sponge/ceRNA), with SAE1 tested as a related target gene."	0.4032
36168415	Experimental and therapeutic medicine	2022	Functional prediction and profiling of exosomal circRNAs derived from seminal plasma for the diagnosis and treatment of oligoasthenospermia.	hsa_circ_0003823				oligoasthenospermia / OAZ	MONDO:0850098	oligoasthenoteratozoospermia	dysregulated	RT-qPCR; RNA-seq	"Exosomal hsa_circ_0003823 is differentially expressed in seminal plasma exosomes from OAZ patients and was validated by RT-qPCR. It was included in a predicted circRNA_miRNA_mRNA network, suggesting a potential ceRNA/miRNA-sponge role, and CEP70 was tested as an associated target gene."	0.4032
36168415	Experimental and therapeutic medicine	2022	Functional prediction and profiling of exosomal circRNAs derived from seminal plasma for the diagnosis and treatment of oligoasthenospermia.	hsa_circ_0125759				oligoasthenospermia / OAZ	MONDO:0850098	oligoasthenoteratozoospermia	dysregulated	RT-qPCR; RNA-seq	"Exosomal hsa_circ_0125759 is differentially expressed in seminal plasma exosomes from OAZ patients and was validated by RT-qPCR. It was used to build a predicted circRNA_miRNA_mRNA network (potential ceRNA mechanism), and MYO9B was tested as an associated target gene; the study suggests exosomal circRNAs may have diagnostic relevance in OAZ."	0.4032
36168415	Experimental and therapeutic medicine	2022	Functional prediction and profiling of exosomal circRNAs derived from seminal plasma for the diagnosis and treatment of oligoasthenospermia.	hsa_circ_0009142				oligoasthenospermia / OAZ	MONDO:0850098	oligoasthenoteratozoospermia	dysregulated	RT-qPCR; RNA-seq	"Exosomal hsa_circ_0009142 is among seven OAZ-associated circRNAs validated by RT-qPCR in seminal plasma exosomes. The study predicts that it participates in a circRNA_miRNA_mRNA network (potential ceRNA regulation), with CAP1 measured as an associated target gene, and suggests diagnostic potential for OAZ."	0.4032
36168415	Experimental and therapeutic medicine	2022	Functional prediction and profiling of exosomal circRNAs derived from seminal plasma for the diagnosis and treatment of oligoasthenospermia.		chr12:130827535-130846146+ / (novel)			oligoasthenospermia / OAZ	MONDO:0850098	oligoasthenoteratozoospermia	dysregulated	RT-qPCR; RNA-seq	"This novel exosomal circRNA (chr12:130827535-130846146+) is differentially expressed in seminal plasma exosomes from OAZ patients and was validated by RT-qPCR. It was incorporated into a predicted circRNA_miRNA_mRNA network consistent with a potential ceRNA mechanism, and SEPT1 was tested as an associated target gene."	0.4032
36168415	Experimental and therapeutic medicine	2022	Functional prediction and profiling of exosomal circRNAs derived from seminal plasma for the diagnosis and treatment of oligoasthenospermia.	hsa_circ_0002452				oligoasthenospermia / OAZ	MONDO:0850098	oligoasthenoteratozoospermia	dysregulated	RT-qPCR; RNA-seq	"Exosomal hsa_circ_0002452 is differentially expressed in seminal plasma exosomes from OAZ patients and was validated by RT-qPCR. It was included in a predicted circRNA_miRNA_mRNA network suggesting a possible ceRNA/miRNA-sponge mechanism, and NEK1 was tested as an associated target gene."	0.4032
36171980	Journal of pain research	2022	Interactions Among Non-Coding RNAs and mRNAs in the Trigeminal Ganglion Associated with Neuropathic Pain.	mmu_circ_0000668				trigeminal neuropathic pain	MONDO:0008599	trigeminal neuralgia	dysregulated	RT-qPCR; RNA-seq	"mmu_circ_0000668 is a differentially expressed circRNA in trigeminal ganglion of CCI-ION mice (trigeminal neuropathic pain model) and its RNA-seq change was validated by RT-qPCR. The study suggests circRNAs in this context may contribute to trigeminal neuropathic pain through ceRNA (circRNA-miRNA-mRNA) regulation, but no specific downstream miRNA/mRNA axis was reported for mmu_circ_0000668."	0.4997
36172827	Balkan medical journal	2022	Circ_0001535 Facilitates Tumor Malignant Progression by miR-485-5p/LASP1 Axis in Colorectal Cancer.	hsa_circ_0001535	circ_0001535	hsa_circ_FAM13B	FAM13B	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0001535 is up-regulated in colorectal cancer and promotes malignant phenotypes (proliferation, invasion, stemness) while suppressing apoptosis. Mechanistically, it mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-485-5p, thereby increasing LASP1 expression and enhancing tumor growth in vivo."	0.8712
36174034	PloS one	2022	Global circRNA expression changes predate clinical and histological improvements of psoriasis patients upon secukinumab treatment.		circPTPRA / circVPS16	hsa_circ_PTPRA	PTPRA	psoriasis	MONDO:0005083	psoriasis	down-regulated	Others	"circPTPRA is downregulated in psoriatic lesional skin compared with non-lesional skin at baseline and progressively normalizes (increases) during secukinumab treatment. Its expression is strongly negatively correlated with PASI, suggesting biomarker potential for disease severity and treatment response."	0.348
36174034	PloS one	2022	Global circRNA expression changes predate clinical and histological improvements of psoriasis patients upon secukinumab treatment.		ciRS-7 / CDR1	hsa_circ_CDR1	CDR1	psoriasis	MONDO:0005083	psoriasis	down-regulated	ISH	"ciRS-7 is reduced in the epidermis of psoriatic lesional skin at baseline and is strongly upregulated during secukinumab therapy, with spatial redistribution/normalization across epidermis and dermis. Its expression negatively correlates with PASI, indicating potential as a severity/response biomarker in skin."	0.4032
36174034	PloS one	2022	Global circRNA expression changes predate clinical and histological improvements of psoriasis patients upon secukinumab treatment.		circTULP4	hsa_circ_TULP4	TULP4	psoriasis	MONDO:0005083	psoriasis	down-regulated	Others	"circTULP4 is downregulated in psoriatic lesional skin at baseline and becomes upregulated/normalized during secukinumab treatment. Its expression is strongly negatively correlated with PASI, supporting potential utility as a skin biomarker of disease severity and treatment response."	0.2995
36176289	Frontiers in genetics	2022	Construction of a focal adhesion signaling pathway-related ceRNA network in pelvic organ prolapse by transcriptome analysis.	hsa_circ_0002190				pelvic organ prolapse / POP	MONDO:0000082	pelvic organ prolapse	unknown	RNA-seq	hsa_circ_0002190 was included in a focal adhesion signaling pathway-related ceRNA network for POP and was predicted to sponge miR-23a-3p to regulate ROCK2 expression.	0.1768
36176289	Frontiers in genetics	2022	Construction of a focal adhesion signaling pathway-related ceRNA network in pelvic organ prolapse by transcriptome analysis.	hsa_circ_0046843				pelvic organ prolapse / POP	MONDO:0000082	pelvic organ prolapse	unknown	RNA-seq	hsa_circ_0046843 was included in a focal adhesion signaling pathway-related ceRNA network for POP and was predicted to sponge miR-23a-3p to regulate ROCK2.	0.1768
36176289	Frontiers in genetics	2022	Construction of a focal adhesion signaling pathway-related ceRNA network in pelvic organ prolapse by transcriptome analysis.	hsa_circ_0001326				pelvic organ prolapse / POP	MONDO:0000082	pelvic organ prolapse	unknown	RNA-seq	"hsa_circ_0001326 was incorporated into a focal adhesion signaling pathway-related ceRNA network in POP and was predicted to sponge miR-205-5p, thereby influencing ROCK2/PPP1R12B/VEGFD."	0.1768
36176289	Frontiers in genetics	2022	Construction of a focal adhesion signaling pathway-related ceRNA network in pelvic organ prolapse by transcriptome analysis.	hsa_circ_0007733				pelvic organ prolapse / POP	MONDO:0000082	pelvic organ prolapse	unknown	RNA-seq	"hsa_circ_0007733 was predicted to act in a POP-related ceRNA network by regulating miR-205-5p, with downstream hub genes ROCK2, PPP1R12B, and VEGFD in the focal adhesion signaling context."	0.1768
36176304	Frontiers in genetics	2022	Downregulation of circLIFR exerts cancer-promoting effects on hepatocellular carcinoma in vitro.	hsa_circ_0072309	circLIFR / circ_0072309	hsa_circ_LIFR	LIFR	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"circLIFR (hsa_circ_0072309) is down-regulated in HCC tissues. Functional assays show circLIFR overexpression promotes HCC cell proliferation, migration/invasion, cell cycle progression and inhibits apoptosis, mechanistically by binding TBK1 and enhancing NF-kappaB activity with increased downstream gene expression (e.g., MMP13, MMP3, VEGF, MAPK)."	0.8072
36176992	Frontiers in cardiovascular medicine	2022	"Differential expression pattern, bioinformatics analysis, and validation of circRNA and mRNA in patients with arteriosclerosis."	hsa_circ_0008706	circRNA-0008706			arteriosclerosis obliterans / ASO	MONDO:0006659	arteriosclerosis obliterans	up-regulated	RT-qPCR; RNA-seq	"circRNA-0008706 is up-regulated in ASO arterial tissues and in PDGF-bb-stimulated HASMCs. Functionally, its knockdown suppresses HASMC proliferation and migration. Mechanistically, it acts as a ceRNA by sponging miR-125b-5p (and is linked to miR-140-3p in the ceRNA network), thereby positively regulating BCAT1 expression."	0.8335
36176992	Frontiers in cardiovascular medicine	2022	"Differential expression pattern, bioinformatics analysis, and validation of circRNA and mRNA in patients with arteriosclerosis."	hsa_circ_0003861	circRNA-0003861			arteriosclerosis obliterans / ASO	MONDO:0006659	arteriosclerosis obliterans	up-regulated	RT-qPCR	"circRNA-0003861 is reported to be up-regulated in ASO arterial tissues and in PDGF-bb-stimulated HASMCs, validated by qPCR. The study did not further characterize its mechanism or functional impact."	0.2995
36180890	Reproductive biology and endocrinology : RB&E	2022	Knockdown circTRIM28 enhances tamoxifen sensitivity via the miR-409-3p/HMGA2 axis in breast cancer.		circTRIM28	hsa_circ_TRIM28	TRIM28	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circTRIM28 is upregulated in breast cancer, particularly in tamoxifen-resistant tissues/cells, and high expression is associated with worse post-operative survival. Functionally, circTRIM28 promotes malignant behaviors and tamoxifen resistance by sponging miR-409-3p to increase HMGA2, while its knockdown enhances tamoxifen sensitivity and suppresses xenograft tumor growth."	0.8819
36181281	Journal of clinical laboratory analysis	2022	Hsa_hsa_circ_0081069 promotes the progression of colorectal cancer through sponging miR-665 and regulating E2F3 expression.	hsa_circ_0081069	circ_0081069	hsa_circ_COL1A2	COL1A2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"hsa_circ_0081069 (derived from COL1A2) is upregulated in colorectal cancer and mainly localized in the cytoplasm. It promotes malignant phenotypes (proliferation, migration/invasion, angiogenesis, tumor growth and metastasis) by sponging miR-665 and thereby increasing E2F3 expression, and high expression is associated with poor patient prognosis."	0.8712
36181462	Cell proliferation	2023	Circ-CTNNB1 drives aerobic glycolysis and osteosarcoma progression via m6A modification through interacting with RBM15.		circ_CTNNB1	hsa_circ_CTNNB1	CTNNB1	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Northern Blot	"Circ-CTNNB1 is up-regulated in osteosarcoma and predominantly nuclear. It promotes OS cell growth, invasion and metastasis by binding the m6A writer RBM15 to enhance m6A modification and stabilize/activate glycolysis genes (HK2, GPI, PGK1), thereby driving aerobic glycolysis and tumor progression."	0.8776
36181865	Life sciences	2022	Role of circular RNA cdr1as in modulation of macrophage phenotype.		circ-Cdr1as / circular RNA Cdr1as	mmu_circ_Cdr1	Cdr1	inflammation	MONDO:0005046	immune system disorder	dysregulated	RT-qPCR; Microarray	"In murine bone marrow-derived macrophages, circ-Cdr1as is decreased in pro-inflammatory (M1-like) polarization and increased in anti-inflammatory (M2-like) polarization. Overexpression promotes anti-inflammatory marker expression and CD206+ cells, while knockdown shifts cells toward a pro-inflammatory phenotype (increased CD86+), and bioinformatic predictions suggest circ-Cdr1as may act through a circRNA_miRNA_mRNA network including miR-7 family."	0.6475
36182807	Redox biology	2022	CircRAPGEF5 interacts with RBFOX2 to confer ferroptosis resistance by modulating alternative splicing of TFRC in endometrial cancer.	hsa_circ_0001681	circRAPGEF5	hsa_circ_RAPGEF5	RAPGEF5	endometrial cancer / EC	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR; RNA-seq	"circRAPGEF5 is up-regulated in endometrial cancer and mainly nuclear. It binds the splicing factor RBFOX2 and reduces RBFOX2 binding to TFRC pre-mRNA, promoting TFRC exon-4 skipping and lowering labile iron and lipid peroxidation, thereby inhibiting ferroptosis and promoting EC cell proliferation and tumor growth."	0.8445
36185502	Experimental and therapeutic medicine	2022	Circular RNA PVT1 promotes progression of thyroid cancer by competitively binding miR-384.		circPVT1 	hsa_circ_PVT1	PVT1	thyroid cancer / TC	MONDO:0002108	thyroid cancer	up-regulated	RT-qPCR	"circPVT1 is up-regulated in thyroid cancer and functions as an oncogenic circRNA, promoting proliferation, colony formation, migration and invasion. Mechanistically, it mainly localizes in the cytoplasm and sponges miR-384, and miR-384 inhibition partially rescues the effects of circPVT1 knockdown. High circPVT1 expression correlates with advanced TNM stage, lymph node metastasis, and poor prognosis."	0.7718
36185580	Journal of orthopaedic translation	2022	Triptolide attenuates inhibition of ankylosing spondylitis-derived mesenchymal stem cells on the osteoclastogenesis through modulating exosomal transfer of circ-0110634.	hsa_circ_0110634	circ-0110634	hsa_circ_TNFRSF1B	TNFRSF1B	Ankylosing spondylitis / AS	MONDO:0005306	ankylosing spondylitis	up-regulated	RT-qPCR	"In ankylosing spondylitis, circ-0110634 is enriched in ASMSC-derived exosomes and accumulates in the cytoplasm of recipient PBMCs, where it suppresses osteoclastogenesis. Mechanistically, it binds TRAF2 and TNFRII, disrupts TRAF2_TNFRII interaction, promotes TRAF2 dimerization and ubiquitination/degradation, and thereby inactivates NF-kappaB and MAPK signaling; triptolide promotes osteoclastogenesis by reducing exosomal transfer/expression of circ-0110634."	0.7849
36186461	Frontiers in genetics	2022	Profile analysis and functional modeling identify circular RNAs in nonalcoholic fatty liver disease as regulators of hepatic lipid metabolism.	mmu_circ_0001452	circ_0001452	mmu_circ_LNCPINT	LNCPINT	nonalcoholic fatty liver disease / NAFLD	MONDO:0013209	metabolic dysfunction-associated steatotic liver disease	down-regulated	RT-qPCR; RNA-seq	"In HFHC diet-induced mouse NAFLD, circ_0001452 (LNCPINT-derived) is down-regulated. Its loss relieves sponging of miR-466i-3p/miR-669c-3p, suppresses AMPK-alpha1 and inactivates AMPK signaling, thereby increasing lipogenic genes (e.g., SREBP1, FASN) and promoting hepatic steatosis."	0.5202
36186461	Frontiers in genetics	2022	Profile analysis and functional modeling identify circular RNAs in nonalcoholic fatty liver disease as regulators of hepatic lipid metabolism.	mmu_circ_0001453	circ_0001453	mmu_circ_LNCPINT	LNCPINT	nonalcoholic fatty liver disease / NAFLD	MONDO:0013209	metabolic dysfunction-associated steatotic liver disease	down-regulated	RT-qPCR; RNA-seq	"circ_0001453 is a LNCPINT-derived mouse hepatic circRNA that is down-regulated in HFHC-induced NAFLD. Its deficiency derepresses miR-466i-3p/miR-669c-3p, contributing to AMPK-alpha1 suppression, AMPK pathway inactivation, and increased lipogenic gene expression promoting steatosis."	0.5202
36186461	Frontiers in genetics	2022	Profile analysis and functional modeling identify circular RNAs in nonalcoholic fatty liver disease as regulators of hepatic lipid metabolism.	mmu_circ_0001454	circ_0001454	mmu_circ_LNCPINT	LNCPINT	nonalcoholic fatty liver disease / NAFLD	MONDO:0013209	metabolic dysfunction-associated steatotic liver disease	down-regulated	RT-qPCR; RNA-seq	"circ_0001454 (LNCPINT-derived) is down-regulated in mouse NAFLD induced by HFHC diet. Its deficiency reduces miRNA sponging, enabling miR-466i-3p/miR-669c-3p to suppress AMPK-alpha1, inactivate AMPK signaling, and enhance lipogenic gene expression contributing to hepatic steatosis."	0.5202
36186461	Frontiers in genetics	2022	Profile analysis and functional modeling identify circular RNAs in nonalcoholic fatty liver disease as regulators of hepatic lipid metabolism.	mmu_circ_0000503	circ_0000503			nonalcoholic fatty liver disease / NAFLD	MONDO:0013209	metabolic dysfunction-associated steatotic liver disease	down-regulated	RT-qPCR; RNA-seq	circ_0000503 is down-regulated in mouse NAFLD liver and is negatively correlated with hepatic triglyceride levels. It is included in the study¡¯s circRNA-miRNA-mRNA network and is predicted/depicted to interact with miR-466i-3p and miR-669c-3p in the proposed steatosis mechanism.	0.5202
36186461	Frontiers in genetics	2022	Profile analysis and functional modeling identify circular RNAs in nonalcoholic fatty liver disease as regulators of hepatic lipid metabolism.	mmu_circ_0001499	circ_0001499			nonalcoholic fatty liver disease / NAFLD	MONDO:0013209	metabolic dysfunction-associated steatotic liver disease	unknown	RNA-seq	"circ_0001499 was identified bioinformatically as one of five key circRNAs in the NAFLD circRNA-miRNA-mRNA regulatory network, sharing target miRNAs (including miR-466i-3p and miR-669c-3p). The provided text does not report independent RT-qPCR validation or detailed functional assays specifically for circ_0001499."	0.3641
36186471	Frontiers in genetics	2022	Identification of the circRNA-miRNA-mRNA regulatory network in osteoarthritis using bioinformatics analysis.	hsa_circ_0075320				Osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	Microarray	"hsa_circ_0075320 is predicted to be up-regulated in OA knee tissues and participates in a bioinformatically inferred ceRNA network. It is proposed to sponge hsa-miR-6124 and thereby relate to hub-gene expression (e.g., COL11A1, SERPINH1, COL5A1, COL8A2, COL15A1) implicated in OA."	0.1768
36186471	Frontiers in genetics	2022	Identification of the circRNA-miRNA-mRNA regulatory network in osteoarthritis using bioinformatics analysis.	hsa_circ_0051428				Osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	Microarray	hsa_circ_0051428 is predicted to be up-regulated in OA knee tissues and is included in the inferred ceRNA network. It is proposed to sponge hsa-miR-1207-5p and associate with COL6A3 as a hub-gene target in OA.	0.1768
36186471	Frontiers in genetics	2022	Identification of the circRNA-miRNA-mRNA regulatory network in osteoarthritis using bioinformatics analysis.	hsa_circ_0003312				Osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	Microarray	hsa_circ_0003312 is identified as an up-regulated DEcircRNA in OA knee tissues and is included as a node in the constructed circRNA_miRNA_mRNA network. The study does not report a specific miRNA/mRNA axis or functional experiments for this circRNA.	0.1768
36187780	Frontiers in physiology	2022	Expression profiling and functional analysis of circular RNAs in vitro model of intermittent hypoxia-induced liver injury.		circRNA1056			liver injury	MONDO:0005154	liver disorder	up-regulated	RT-qPCR; RNA-seq	circRNA1056 is up-regulated in intermittent hypoxia-treated BRL-3A liver cells and was validated by RT-qPCR. The study constructed a predicted circRNA_miRNA_mRNA network suggesting circRNA1056 may act as a miRNA sponge to regulate downstream genes in IH-induced liver cell injury.	0.3858
36187780	Frontiers in physiology	2022	Expression profiling and functional analysis of circular RNAs in vitro model of intermittent hypoxia-induced liver injury.		circRNA508			liver injury	MONDO:0005154	liver disorder	up-regulated	RT-qPCR; RNA-seq	"circRNA508 is up-regulated in intermittent hypoxia-treated BRL-3A liver cells and this change was confirmed by RT-qPCR, consistent with RNA-seq."	0.3401
36187780	Frontiers in physiology	2022	Expression profiling and functional analysis of circular RNAs in vitro model of intermittent hypoxia-induced liver injury.		circRNA2262			liver injury	MONDO:0005154	liver disorder	up-regulated	RT-qPCR; RNA-seq	"circRNA2262 is up-regulated in intermittent hypoxia-treated BRL-3A liver cells and this change was confirmed by RT-qPCR, consistent with RNA-seq."	0.3401
36187780	Frontiers in physiology	2022	Expression profiling and functional analysis of circular RNAs in vitro model of intermittent hypoxia-induced liver injury.		ciRNA1142			liver injury	MONDO:0005154	liver disorder	down-regulated	RT-qPCR; RNA-seq	"ciRNA1142 is down-regulated in intermittent hypoxia-treated BRL-3A liver cells and this change was confirmed by RT-qPCR, consistent with RNA-seq."	0.3401
36187780	Frontiers in physiology	2022	Expression profiling and functional analysis of circular RNAs in vitro model of intermittent hypoxia-induced liver injury.		circRNA4218			liver injury	MONDO:0005154	liver disorder	down-regulated	RT-qPCR; RNA-seq	"circRNA4218 is down-regulated in intermittent hypoxia-treated BRL-3A liver cells and this change was confirmed by RT-qPCR, consistent with RNA-seq."	0.3401
36187780	Frontiers in physiology	2022	Expression profiling and functional analysis of circular RNAs in vitro model of intermittent hypoxia-induced liver injury.		circRNA805			liver injury	MONDO:0005154	liver disorder	down-regulated	RT-qPCR; RNA-seq	circRNA805 is down-regulated in intermittent hypoxia-treated BRL-3A liver cells and was validated by RT-qPCR. The study predicts circRNA805 may regulate downstream genes via a circRNA_miRNA_mRNA network consistent with a ceRNA mechanism.	0.3858
36187840	Frontiers in veterinary science	2022	Analysis of circRNA expression in chicken HD11 cells in response to avian pathogenic E.coli.		circRAB11A 	gga_circ_RAB11A	RAB11A	APEC infection / avian pathogenic E. coli infection / colibacillosis	MONDO:0020920	escherichia coli infection	unknown	RT-qPCR; RNA-seq	"circRAB11A is a differentially expressed circRNA in APEC-infected chicken HD11 macrophages and was experimentally validated. The study highlights circRAB11A as part of immune-related ceRNA interactions, particularly circRAB11A_gga-miR-125b-3p and circRAB11A_gga-miR-1696, suggesting a role in host immune response to APEC infection."	0.4761
36187840	Frontiers in veterinary science	2022	Analysis of circRNA expression in chicken HD11 cells in response to avian pathogenic E.coli.		circTSC2 	gga_circ_TSC2	TSC2	APEC infection / avian pathogenic E. coli infection / colibacillosis	MONDO:0020920	escherichia coli infection	unknown	RNA-seq	"circTSC2 is a differentially expressed circRNA identified in APEC-infected HD11 cells, highlighted for extensive predicted miRNA-binding capacity. The study proposes an immune-related ceRNA interaction circTSC2_gga-miR-1649-5p in the host response to APEC infection."	0.1768
36187840	Frontiers in veterinary science	2022	Analysis of circRNA expression in chicken HD11 cells in response to avian pathogenic E.coli.		circBCL2L13	gga_circ_BCL2L13	BCL2L13	APEC infection / avian pathogenic E. coli infection / colibacillosis	MONDO:0020920	escherichia coli infection	unknown	RT-qPCR; RNA-seq	"circBCL2L13 is a validated differentially expressed circRNA in APEC-infected HD11 cells. It is predicted to sponge multiple miRNAs, and the paper highlights a potential immune-defense role via targeting gga-miR-130b-5p."	0.4761
36187840	Frontiers in veterinary science	2022	Analysis of circRNA expression in chicken HD11 cells in response to avian pathogenic E.coli.		circCDC42	gga_circ_CDC42	CDC42	APEC infection / avian pathogenic E. coli infection / colibacillosis	MONDO:0020920	escherichia coli infection	unknown	RT-qPCR; RNA-seq	"circCDC42 is a validated differentially expressed circRNA in APEC-infected HD11 cells. It harbors multiple predicted miRNA-binding sites, suggesting a potential role in modulating immune-related gene expression through a miRNA-sponge mechanism during APEC infection."	0.4761
36187840	Frontiers in veterinary science	2022	Analysis of circRNA expression in chicken HD11 cells in response to avian pathogenic E.coli.			gga_circ_BRAF	BRAF	APEC infection / avian pathogenic E. coli infection / colibacillosis	MONDO:0020920	escherichia coli infection	down-regulated	RNA-seq	"The BRAF-derived circRNA (1:56932512-56949904) is significantly down-regulated in APEC-infected HD11 cells. The paper discusses it as an interesting circRNA potentially related to immune-response pathways (MAPK/ERK) based on its host gene, but provides no direct functional validation."	0.1768
36187840	Frontiers in veterinary science	2022	Analysis of circRNA expression in chicken HD11 cells in response to avian pathogenic E.coli.			gga_circ_PPP3CB	PPP3CB	APEC infection / avian pathogenic E. coli infection / colibacillosis	MONDO:0020920	escherichia coli infection	unknown	RNA-seq	"The PPP3CB-derived circRNA (6:16997989-17005138) is discussed as an interesting candidate in the APEC vs WT comparison. Its role is speculative, inferred from the immune relevance of its host gene, without reported experimental validation for this circRNA."	0.1768
36187840	Frontiers in veterinary science	2022	Analysis of circRNA expression in chicken HD11 cells in response to avian pathogenic E.coli.			gga_circ_RAB11FIP2	RAB11FIP2	APEC infection / avian pathogenic E. coli infection / colibacillosis	MONDO:0020920	escherichia coli infection	unknown	RNA-seq	"The RAB11FIP2-derived circRNA (6:30450791-30452406) is discussed as an interesting candidate in APEC infection. Its relevance is speculative, inferred from the immune/phagocytosis-related functions of its host gene, without direct experimental validation for this circRNA."	0.1768
36190397	European journal of histochemistry : EJH	2022	Overexpression of hsa_circ_0006470 inhibits the malignant behavior of gastric cancer cells <em>via</em> regulation of miR-1234/TP53I11 axis.	hsa_circ_0006470	hsa-circ-0006470			gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"In gastric cancer cell lines, hsa_circ_0006470 is down-regulated and mainly localized in the cytoplasm. Its overexpression suppresses viability/proliferation and migration and induces G1 arrest. Mechanistically, it acts as a miR-1234 sponge to increase TP53I11 expression, with downstream changes consistent with inhibition of AKT signaling (reduced p-Akt) and cell-cycle regulators (reduced CDK2, increased FOXO1)."	0.6737
36192755	World journal of surgical oncology	2022	Circ_0000808 promotes the development of non-small cell lung cancer by regulating glutamine metabolism via the miR-1827/SLC1A5 axis.	hsa_circ_0000808	Circ_0000808	hsa_circ_SEPT9	SEPT9	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0000808 is upregulated in NSCLC and promotes malignant phenotypes (proliferation, migration/invasion, tumor growth) while inhibiting apoptosis. Mechanistically, it functions as a ceRNA by sponging miR-1827 to upregulate SLC1A5, thereby enhancing glutamine metabolism in NSCLC cells."	0.8299
36193069	Oxidative medicine and cellular longevity	2022	Circ_0000189 Promotes the Malignancy of Glioma Cells via Regulating miR-192-5p-ZEB2 Axis.	hsa_circ_0000189	circ_0000189			glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ_0000189 is up-regulated in glioma tissues and cell lines and acts as an oncogenic circRNA. It sponges miR-192-5p to increase ZEB2, thereby promoting proliferation, migration/invasion and EMT while inhibiting apoptosis, and it enhances tumor growth and lung metastasis in vivo."	0.7598
36193508	Disease markers	2022	hsa_circ_0003176 Suppresses the Progression of Non-Small-Cell Lung Cancer via Regulating miR-182-5p/RBM5 Axis.	hsa_circ_0003176	circ_0003176	hsa_circ_TBX5	TBX5	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"In NSCLC, hsa_circ_0003176 is down-regulated and functions as a tumor suppressor by inhibiting proliferation, migration, invasion, and in vivo tumor growth/metastasis. Mechanistically, it sponges miR-182-5p to relieve repression of RBM5 (circRNA/miRNA/mRNA axis), and shows potential diagnostic value by ROC analysis."	0.8683
36193788	Thoracic cancer	2022	"Circ-EIF3I facilitates proliferation, migration, and invasion of lung cancer via regulating the activity of Wnt/beta-catenin pathway through the miR-1253/NOVA2 axis."	hsa_circ_0011385	Circ_EIF3I / circ_100_146	hsa_circ_EIF3I	EIF3I	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; Microarray	"circ-EIF3I (hsa_circ_0011385), derived from EIF3I, is upregulated in lung cancer and promotes malignant phenotypes (proliferation, migration/invasion) while inhibiting apoptosis. Mechanistically, it sponges miR-1253 to increase NOVA2 and thereby activates Wnt/beta-catenin signaling, enhancing tumor growth in vivo and associating with poor overall survival."	0.8069
36199071	Molecular cancer	2022	Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the beta-TrCP/c-Myc/SRSF1 positive feedback loop.	hsa_circ_0001821	circPVT1	hsa_circ_PVT1	PVT1	nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circPVT1 is up-regulated in nasopharyngeal carcinoma and promotes migration, invasion, and metastasis. It binds beta-TrCP to inhibit beta-TrCP-mediated ubiquitination and degradation of c-Myc, stabilizing c-Myc to drive cytoskeleton remodeling/cell adhesion changes; c-Myc and SRSF1 further enhance circPVT1 biogenesis, forming a beta-TrCP/c-Myc/SRSF1 positive feedback loop."	0.8863
36200070	Frontiers in molecular biosciences	2022	Upregulation of circ_0008812 and circ_0001583 predicts poor prognosis and promotes breast cancer proliferation.	hsa_circ_0008812	circ_0008812	hsa_circ_RAD23B	RAD23B	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circ_0008812 is up-regulated in breast cancer datasets and is highly expressed in MCF-7 cells. siRNA-mediated knockdown suppresses MCF-7 proliferation, and the study proposes a prognostic ceRNA axis circ_0008812/miR-4554-3p/RACGAP1 linked to poor prognosis."	0.5923
36200070	Frontiers in molecular biosciences	2022	Upregulation of circ_0008812 and circ_0001583 predicts poor prognosis and promotes breast cancer proliferation.	hsa_circ_0001583	circ_0001583	hsa_circ_HIST1H1C	HIST1H1C	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circ_0001583 is up-regulated in breast cancer datasets and highly expressed in MCF-7 cells. Knockdown reduces MCF-7 proliferation, and the study proposes prognostic ceRNA axes linking circ_0001583 to KPNA2 via miR-93-5p, miR-6715a-3p, and miR-17-5p, associated with poor prognosis."	0.5923
36209117	Journal of experimental & clinical cancer research : CR	2022	Exosomal circZNF451 restrains anti-PD1 treatment in lung adenocarcinoma via polarizing macrophages by complexing with TRIM56 and FXR1.	hsa_circ_0002638	circZNF451	hsa_circ_ZNF451	ZNF451	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"In LUAD, exosomal circZNF451 is up-regulated in patients resistant to PD1 blockade and associates with poor prognosis. Mechanistically, it scaffolds TRIM56 and FXR1 in macrophages to promote FXR1 ubiquitination/degradation, activating the ELF4_IRF4 program to drive M2-like polarization and suppress CD8+ T cell cytotoxicity, reducing anti-PD1 efficacy."	0.8926
36209140	Cell death & disease	2022	CircRNF144B/miR-342-3p/FBXL11 axis reduced autophagy and promoted the progression of ovarian cancer by increasing the ubiquitination of Beclin-1.		circRNF144B	hsa_circ_RNF144B	RNF144B	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; RNA-seq	"circRNF144B is up-regulated in ovarian cancer and correlates with poorer patient survival. It promotes proliferation, migration/invasion and in vivo tumor growth/metastasis while suppressing autophagy by sponging miR-342-3p to increase FBXL11, which enhances Beclin-1 ubiquitination and degradation."	0.8817
36210930	Frontiers in pediatrics	2022	Circulating circular RNA profiles associated with celiac disease seropositivity in children with type 1 diabetes.	hsa_circ_0004564		hsa_circ_RAPH1	RAPH1	type 1 diabetes mellitus / T1DM	MONDO:0005147	type 1 diabetes mellitus	down-regulated	RT-qPCR; Microarray	"In PBMCs from Han Chinese children with T1D, hsa_circ_0004564 is significantly down-regulated in the CDAb+ group versus the CDAb_ group. Its host gene RAPH1 is up-regulated in CDAb+ patients, and hsa_circ_0004564 expression is positively correlated with CD3+ T cells, suggesting a role in immune mechanisms underlying T1D with celiac seropositivity."	0.4997
36217445	Journal of hepatocellular carcinoma	2022	Circular RNA circRASSF5 Functions as an Anti-Oncogenic Factor in Hepatocellular Carcinoma by Acting as a Competitive Endogenous RNA Through Sponging miR-331-3p.	hsa_circ_0016242	circRASSF5	hsa_circ_RASSF5	RASSF5	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"circRASSF5 is down-regulated in HCC and functions as a tumor suppressor by inhibiting proliferation, migration, invasion and metastasis in vitro and in xenograft models. It mainly localizes to the cytoplasm and acts as a ceRNA sponge for miR-331-3p, thereby increasing PHLPP1/PHLPP2 expression. Low circRASSF5 is associated with aggressive clinicopathologic features and poorer survival."	0.8596
36221294	BioMed research international	2022	Expression Profiles and Functional Analysis of Plasma Exosomal Circular RNAs in Acute Myocardial Infarction.	hsa_circ_0061776		hsa_circ_BACE2	BACE2	acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	up-regulated	RNA-seq	Plasma exosomal hsa_circ_0061776 is up-regulated in AMI (vs controls) and is predicted to sponge has-miR-133a/has-miR-214/has-miR-423/has-miR-217. Bioinformatics analyses suggest its parental gene enrichment in lysine degradation and potential involvement in AMI through the MAPK signaling pathway as part of a ceRNA network.	0.1768
36221294	BioMed research international	2022	Expression Profiles and Functional Analysis of Plasma Exosomal Circular RNAs in Acute Myocardial Infarction.	hsa_circ_0004093		hsa_circ_MAP7D1	MAP7D1	acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	up-regulated	RNA-seq	Plasma exosomal hsa_circ_0004093 is differentially expressed and up-regulated in AMI vs CAD (as reported in the AMI vs CAD analysis). It is highlighted as potentially involved in AMI/CAD and related to the MAPK signaling pathway based on bioinformatics analyses.	0.1768
36221294	BioMed research international	2022	Expression Profiles and Functional Analysis of Plasma Exosomal Circular RNAs in Acute Myocardial Infarction.	hsa_circ_0007201		hsa_circ_IQGAP1	IQGAP1	acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	up-regulated	RNA-seq	"Plasma exosomal hsa_circ_0007201 is up-regulated (reported in CAD vs control and AMI vs CAD). It is predicted to function as a miRNA sponge for has-miR-34a/has-miR-208a/has-miR-92a and is suggested to influence CAD/AMI-related processes, with MAPK signaling pathway enrichment implicated in the AMI vs CAD comparison."	0.1768
36221294	BioMed research international	2022	Expression Profiles and Functional Analysis of Plasma Exosomal Circular RNAs in Acute Myocardial Infarction.	hsa_circ_0006041		hsa_circ_TPST1	TPST1	coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	up-regulated	RNA-seq	Plasma exosomal hsa_circ_0006041 is up-regulated in CAD vs controls. Bioinformatics prediction suggests it may act as a ceRNA/miRNA sponge for has-miR-145/has-miR-143/has-miR-216 and may be a pathogenic circRNA in CAD.	0.1768
36224562	Molecular cancer	2022	The FUS/circEZH2/KLF5/ feedback loop contributes to CXCR4-induced liver metastasis of breast cancer by enhancing epithelial-mesenchymal transition.	hsa_circ_0008324	circEZH2	hsa_circ_EZH2	EZH2	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; ISH; Microarray	"circEZH2 (hsa_circ_0008324), derived from EZH2, is upregulated in breast cancer liver metastases and promotes proliferation, invasion, EMT, and liver metastasis. Mechanistically, it sponges miR-217-5p to increase KLF5, which activates FUS (enhancing circEZH2 back-splicing) and CXCR4 transcription, forming a FUS/circEZH2/KLF5/CXCR4 positive feedback loop. High circEZH2 expression is associated with worse prognosis in breast cancer patients."	0.8973
36224588	Molecular cancer	2022	Two circPPFIA1s negatively regulate liver metastasis of colon cancer via miR-155-5p/CDX1 and HuR/RAB36.	hsa_circ_0003429	circPPFIA1-L / circRNA_100873	hsa_circ_PPFIA1	PPFIA1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	"circPPFIA1-L (hsa_circ_0003429) is downregulated in liver-metastatic CRC models and patient liver metastatic tissues. It suppresses invasion/migration and liver metastasis by sponging miR-155-5p to relieve repression of CDX1, and by sequestering HuR to reduce HuR-stabilized RAB36 expression."	0.8439
36224588	Molecular cancer	2022	Two circPPFIA1s negatively regulate liver metastasis of colon cancer via miR-155-5p/CDX1 and HuR/RAB36.	hsa_circ_0000337	circPPFIA1-S / hsa_circRNA_100872	hsa_circ_PPFIA1	PPFIA1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	"circPPFIA1-S (hsa_circ_0000337) is downregulated in liver-metastatic CRC models and patient liver metastatic tissues. It suppresses invasion/migration and liver metastasis by sponging miR-155-5p to increase CDX1, and by binding/sequestering HuR to reduce HuR-driven RAB36 mRNA stabilization and expression."	0.8439
36225588	Frontiers in pharmacology	2022	Circular RNA hsa_circ_0003574 as a biomarker for prediction and diagnosis of ischemic stroke caused by intracranial atherosclerotic stenosis.	hsa_circ_0003574	hsa_circRNA_0003574 / circRNA_0003574	hsa_circ_GID8	GID8	ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; Microarray	"hsa_circ_0003574 (host gene GID8) is significantly up-regulated in peripheral blood of patients with ICAS-stroke versus normal controls and is proposed as a biomarker for prediction/diagnosis. The study also constructs a bioinformatically predicted circRNA_miRNA_mRNA network suggesting potential downstream interactions, but does not experimentally validate the mechanism."	0.4032
36227125	Cancer science	2023	circTOP2A functions as a ceRNA to promote glioma progression by upregulating RPN2.	hsa_circ_0106819	circTOP2A / hsa_circ_0106819	hsa_circ_TOP2A	TOP2A	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; Microarray	"circTOP2A (hsa_circ_0106819) is up-regulated in glioma and promotes proliferation and invasion while suppressing apoptosis. Mechanistically, it functions as a ceRNA that sponges miR-422a to upregulate RPN2, thereby enhancing Wnt/beta-catenin signaling and tumor growth in vivo."	0.866
36228165	Chinese medical journal	2023	Expression profile of circRNA in biliary atresia and choledochal cyst.	hsa_circ_0009096				biliary atresia / BA	MONDO:0008867	biliary atresia	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0009096 is up-regulated in BA liver tissue versus CC and shows diagnostic value for BA by ROC analysis. It was selected from circRNA-seq as a circRNA predicted (via a ceRNA framework) to relate to the TGF-beta signaling pathway, though its specific mechanism was not functionally characterized in this study."	0.6238
36230873	Cancers	2022	CircKIF4A Is a Prognostic Factor and Modulator of Natural Killer/T-Cell Lymphoma Progression.		circKIF4A	hsa_circ_KIF4A	KIF4A	Natural killer/T-cell lymphoma / NKTL	MONDO:0019472	extranodal nasal NK/T cell lymphoma	up-regulated	RT-qPCR	"circKIF4A is up-regulated in NKTL and high expression is associated with worse OS/PFS. Functionally, circKIF4A promotes NKTL glycolysis (glucose uptake and lactate production) by acting as a ceRNA that sponges miR-1231, thereby increasing PDK1 and BCL11A expression."	0.8487
36230932	Cells	2022	Regulation Networks of Non-Coding RNA-Associated ceRNAs in Cisplatin-Induced Acute Kidney Injury.		circRNA_3907			acute kidney injury / AKI	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR; RNA-seq	"In a cisplatin-induced AKI mouse model, circRNA_3907 is up-regulated and forms a validated ceRNA axis with mmu-miR-185-3p and the target gene Ptprn. This suggests circRNA_3907 may contribute to CP-AKI through ceRNA-mediated regulation."	0.4032
36241975	Biological procedures online	2022	Circ_0003570 Suppresses the progression of hepatocellular carcinoma through miR-182-5p/STARD13 regulatory axis.	hsa_circ_0003570	Circ_0003570	hsa_circ_FAM53B	FAM53B	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"circ_0003570 is down-regulated in HCC cell lines and acts as a tumor suppressor. It sponges miR-182-5p to de-repress STARD13, thereby inhibiting proliferation, migration, invasion and metastasis of HCC cells in vitro and in vivo."	0.6544
36242088	Journal of orthopaedic surgery and research	2022	Circular RNA circ_0008365 regulates SOX9 by targeting miR-338-3p to inhibit IL-1beta-induced chondrocyte apoptosis and extracellular matrix degradation.	hsa_circ_0008365	circ_0008365	hsa_circ_SERPINE2	SERPINE2	Osteoarthritis / OA	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR	"circ_0008365 is down-regulated in OA cartilage and in IL-1beta-treated CHON-001 cells. It alleviates IL-1beta-induced chondrocyte injury by sponging miR-338-3p and restoring SOX9, thereby promoting proliferation and inhibiting apoptosis and extracellular matrix degradation. Serum exosomal circ_0008365 shows diagnostic potential for OA (high AUC)."	0.8562
36243865	Journal of ovarian research	2022	Circular RNA hsa_circ_0000144 aggravates ovarian Cancer progression by regulating ELK3 via sponging miR-610.	hsa_circ_0000144	circ_0000144	hsa_circ_SLAMF6	SLAMF6	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"hsa_circ_0000144 is upregulated in ovarian cancer tissues, serum, and cell lines and promotes proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, it functions as a ceRNA by sponging miR-610 to increase ELK3 expression, and high circ_0000144 expression is associated with worse OS/DFS."	0.8496
36243874	Cell death & disease	2022	Self-restricted circular RNA circSOX2 suppressed the malignant progression in SOX2-amplified LUSC.	hsa_circ_0122884	CircSOX2 / cicSOX2	hsa_circ_SOX2	SOX2	lung squamous cell carcinoma / LUSC	MONDO:0005097	squamous cell lung carcinoma	up-regulated	RT-qPCR	"CircSOX2 is up-regulated in SOX2-amplified LUSC and functions as a tumor suppressor. It localizes predominantly to the nucleus, binds AUF1, and base-pairs with the reverse-complementary region of the mSOX2 3'UTR to recruit AUF1 and promote mSOX2 degradation, thereby inhibiting malignant behaviors and associating with better survival in SOX2-amplified patients."	0.8912
36244799	International dental journal	2023	CircFKBP5 Suppresses Apoptosis and Inflammation and Promotes Osteogenic Differentiation.	hsa_circ_0001599	circFKBP5 / hsa_circRNA_104101	hsa_circ_FKBP5	FKBP5	pulpitis	MONDO:0006937	pulpitis	down-regulated	RT-qPCR	"In LPS-treated human dental pulp stem cells (an in vitro pulpitis-like inflammatory model), circFKBP5 is down-regulated and its re-expression protects cells by reducing apoptosis and inflammatory cytokine release while restoring proliferation and osteogenic differentiation. Mechanistically, circFKBP5 sponges miR-708-5p to relieve repression of GIT2, forming a circFKBP5/miR-708-5p/GIT2 regulatory axis."	0.7256
36249712	International journal of genomics	2022	circPTN Promotes the Progression of Non-Small Cell Lung Cancer through Upregulation of E2F2 by Sponging miR-432-5p.		circPTN / cicrPTN	hsa_circ_PTN	PTN	Non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circPTN is up-regulated in NSCLC tissues/cells and promotes malignant behaviors (proliferation, migration/invasion, EMT and angiogenesis-like tube formation). Mechanistically, it sponges miR-432-5p to upregulate E2F2, and high circPTN expression is associated with worse overall survival, suggesting prognostic value."	0.7976
36254231	Oxidative medicine and cellular longevity	2022	CircCRIM1 Ameliorates Endothelial Cell Angiogenesis in Aging through the miR-455-3p/Twist1/VEGFR2 Signaling Axis.	mmu_circ_0007020	circCRIM1	mmu_circ_CRIM1	CRIM1	Peripheral artery disease / PAD	MONDO:0005386	peripheral arterial disease	down-regulated	RT-qPCR; RNA-seq	"mmu_circ_0007020 (circCRIM1) is down-regulated in aging endothelial cells and an aging hindlimb ischemia model. It promotes endothelial angiogenesis by sponging miR-455-3p, thereby increasing Twist1 and enhancing VEGFR2 expression to improve ischemic blood flow recovery."	0.8231
36259450	Cancer medicine	2023	Hsa_circ_0001445 works as a cancer suppressor via miR-576-5p/SFRP1 axis regulation in ovarian cancer.	hsa_circ_0001445	circSMARCA5 / circ1445	hsa_circ_SMARCA5	SMARCA5	ovarian cancer / OC	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR	"hsa_circ_0001445 (hcR1445/circSMARCA5) is down-regulated in ovarian cancer and functions as a tumor suppressor. It sponges miR-576-5p to increase SFRP1, thereby inhibiting WNT/beta-catenin signaling and reducing proliferation, migration, invasion and in vivo metastasis while promoting apoptosis; higher hcR1445 correlates with longer patient survival."	0.8712
36262967	BioMed research international	2022	The Elevated Circ_0067835 Could Accelerate Cell Proliferation and Metastasis via miR-1236-3p/Twist2 Axis in Hepatocellular Carcinoma.	hsa_circ_0067835	Circ_0067835 / circ_ 0067835			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0067835 is up-regulated in HCC tissues/cell lines and is associated with metastasis, larger tumor size, and poorer overall survival. Functionally, circ_0067835 promotes proliferation and migration/metastasis by sponging miR-1236-3p, which leads to increased Twist2 expression."	0.7325
36263172	International journal of biological sciences	2022	"Circular RNA hsa_circ_0003823 promotes the Tumor Progression, Metastasis and Apatinib Resistance of Esophageal Squamous Cell Carcinoma by miR-607/CRISP3 Axis."	hsa_circ_0003823	circCEP70 / circ0003823	hsa_circ_CEP70	CEP70	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"hsa_circ_0003823 (circCEP70) is up-regulated in ESCC and mainly localized in the cytoplasm. It functions as a ceRNA by sponging miR-607 to upregulate CRISP3, thereby promoting ESCC proliferation, invasion/migration/metastasis and increasing resistance to Apatinib; high expression correlates with advanced stage and worse survival."	0.8846
36263181	International journal of biological sciences	2022	Regulation of Podocyte Injury by CircHIPK3/FUS Complex in Diabetic Kidney Disease.	hsa_circ_0000284	circHIPK3 / CircRNA HIPK3	hsa_circ_HIPK3	HIPK3	diabetic kidney disease / DKD	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in DKD-associated podocyte injury models and in diabetic mouse glomeruli. It promotes podocyte apoptosis by binding the RBP FUS and enhancing FUS occupancy on the EDA2R promoter, increasing EDA2R transcription and activating apoptotic signaling; silencing circHIPK3 ameliorates podocyte injury and albuminuria in STZ-induced diabetic mice."	0.8682
36263181	International journal of biological sciences	2022	Regulation of Podocyte Injury by CircHIPK3/FUS Complex in Diabetic Kidney Disease.	mmu_circ_0001052	circHIPK3 / CircRNA HIPK3	mmu_circ_HIPK3	HIPK3	diabetic kidney disease / DKD	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in DKD-associated podocyte injury models and in diabetic mouse glomeruli. It promotes podocyte apoptosis by binding the RBP FUS and enhancing FUS occupancy on the EDA2R promoter, increasing EDA2R transcription and activating apoptotic signaling; silencing circHIPK3 ameliorates podocyte injury and albuminuria in STZ-induced diabetic mice."	0.8682
36263320	Frontiers in endocrinology	2022	Downregulationof circ_0001578 promotes gestational diabetes mellitus by inducing placental inflammation via the NF-kappaB and JNKs pathways.	hsa_circ_0001578	circ_0001578 / circRNA_0001578	hsa_circ_RANBP9	RANBP9	gestational diabetes mellitus / GDM	MONDO:0005406	gestational diabetes	down-regulated	RT-qPCR; RNA-seq	"circ_0001578 is significantly down-regulated in placental villous tissue and placenta-derived plasma exosomes in GDM. Its knockdown in trophoblasts suppresses proliferation/migration and increases apoptosis and inflammatory cytokines, linked to activation of NF-kappaB and JNK signaling. Second-trimester exosomal circ_0001578 shows diagnostic/predictive potential for later GDM."	0.7375
36266731	Journal of experimental & clinical cancer research : CR	2022	CircLRFN5 inhibits the progression of glioblastoma via PRRX2/GCH1 mediated ferroptosis.	hsa_circ_0031751	circLRFN5	hsa_circ_LRFN5	LRFN5	glioblastoma / GBM	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR; RNA-seq	"circLRFN5 (hsa_circ_0031751), derived from LRFN5, is down-regulated in GBM and low expression correlates with worse survival. Functionally it suppresses GSC proliferation/stemness and tumorigenesis by promoting ferroptosis, mechanistically through binding PRRX2 and facilitating its ubiquitin_proteasome degradation, which reduces PRRX2-driven GCH1 transcription."	0.8912
36267594	International journal of genomics	2022	Expression Profiles of Differentially Expressed Circular RNAs and circRNA-miRNA-mRNA Regulatory Networks in SH-SY5Y Cells Infected with Coxsackievirus B5.	hsa_circ_0008378				Coxsackievirus Group B5 infection	MONDO:0005721	coxsackievirus infectious disease	down-regulated	RT-qPCR; RNA-seq	"In CVB5-infected SH-SY5Y cells, hsa_circ_0008378 is down-regulated but functionally inhibits viral replication when overexpressed, by promoting key factors in the IFN-I pathway. It participates in a predicted circRNA_miRNA_mRNA (ceRNA) network linked to JAK-STAT/IFN signaling."	0.4474
36267594	International journal of genomics	2022	Expression Profiles of Differentially Expressed Circular RNAs and circRNA-miRNA-mRNA Regulatory Networks in SH-SY5Y Cells Infected with Coxsackievirus B5.	hsa_circ_0014617	novel_circ_0014617			Coxsackievirus Group B5 infection	MONDO:0005721	coxsackievirus infectious disease	up-regulated	RT-qPCR; RNA-seq	"In CVB5-infected SH-SY5Y cells, novel_circ_0014617 (also reported as hsa_circ_0014617) is up-regulated and inhibits viral replication when overexpressed by promoting key factors in the IFN-I pathway. It is part of a predicted circRNA_miRNA_mRNA network linked to innate immune response, including a RIG-I signaling pathway-related subnetwork."	0.4474
36267594	International journal of genomics	2022	Expression Profiles of Differentially Expressed Circular RNAs and circRNA-miRNA-mRNA Regulatory Networks in SH-SY5Y Cells Infected with Coxsackievirus B5.	hsa_circ_0008650				Coxsackievirus Group B5 infection	MONDO:0005721	coxsackievirus infectious disease	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0008650 is up-regulated in CVB5-infected SH-SY5Y cells and was validated by RT-qPCR consistent with RNA-seq. The paper does not further specify its mechanism or function beyond differential expression validation.	0.1904
36267594	International journal of genomics	2022	Expression Profiles of Differentially Expressed Circular RNAs and circRNA-miRNA-mRNA Regulatory Networks in SH-SY5Y Cells Infected with Coxsackievirus B5.	hsa_circ_0002030	novel_circ_0002030			Coxsackievirus Group B5 infection	MONDO:0005721	coxsackievirus infectious disease	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0002030 (also referred to as novel_circ_0002030) is up-regulated in CVB5-infected SH-SY5Y cells and was validated by RT-qPCR consistent with RNA-seq. No specific downstream mechanism or function was reported for this circRNA in the study.	0.1904
36267594	International journal of genomics	2022	Expression Profiles of Differentially Expressed Circular RNAs and circRNA-miRNA-mRNA Regulatory Networks in SH-SY5Y Cells Infected with Coxsackievirus B5.	hsa_circ_0004299				Coxsackievirus Group B5 infection	MONDO:0005721	coxsackievirus infectious disease	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0004299 is down-regulated in CVB5-infected SH-SY5Y cells and was validated by RT-qPCR consistent with RNA-seq. The study did not report a specific mechanism or functional role for this circRNA beyond differential expression validation.	0.1904
36267594	International journal of genomics	2022	Expression Profiles of Differentially Expressed Circular RNAs and circRNA-miRNA-mRNA Regulatory Networks in SH-SY5Y Cells Infected with Coxsackievirus B5.	hsa_circ_0010796				Coxsackievirus Group B5 infection	MONDO:0005721	coxsackievirus infectious disease	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0010796 is down-regulated in CVB5-infected SH-SY5Y cells and was validated by RT-qPCR consistent with RNA-seq. The study did not further define its mechanism or role beyond expression validation.	0.1904
36267728	Annals of translational medicine	2022	Hsa_circ_0099630 knockdown induces the proliferation and osteogenic differentiation and attenuates the apoptosis of porphyromonas gingivalis lipopolysaccharide-induced human periodontal ligament fibroblasts.	hsa_circ_0099630		hsa_circ_RMST	RMST	periodontitis	MONDO:0005076	periodontitis	up-regulated	RT-qPCR	"hsa_circ_0099630 is up-regulated in gingival tissues from patients with periodontitis and increases in Pg-LPS-induced HPLFs. Functionally, hsa_circ_0099630 overexpression inhibits proliferation and osteogenic differentiation while promoting apoptosis, whereas its knockdown reverses these effects. The study predicts a potential circRNA_miRNA_mRNA network involving miR-182/miR-1200/miR-338/miR-576/miR-623, but does not experimentally validate specific downstream targets."	0.725
36267792	Annals of translational medicine	2022	Circ_0001658 regulates PI3K/AKT signaling via the miR-671-5p/ITGA2 axis and affects the progress of papillary thyroid carcinoma.	hsa_circ_0001658	circ_0001658			papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circ_0001658 is up-regulated in papillary thyroid carcinoma tissues and cell lines. It mainly localizes to the cytoplasm and promotes PTC cell proliferation, migration and invasion by sponging miR-671-5p to up-regulate ITGA2 and activate PI3K/AKT signaling."	0.7759
36267809	Oxidative medicine and cellular longevity	2022	circMTND5 Participates in Renal Mitochondrial Injury and Fibrosis by Sponging MIR6812 in Lupus Nephritis.		circMTND5	hsa_circ_MTND5	MTND5	lupus nephritis / LN	MONDO:0005556	lupus nephritis	down-regulated	RT-qPCR; ISH; RNA-seq	"In lupus nephritis kidney biopsies, circMTND5 is markedly down-regulated and primarily enriched in mitochondria of renal tubular epithelial cells. Functionally, circMTND5 mitigates mitochondrial injury and fibrotic responses by sponging MIR6812 (AGO2-associated), thereby relieving MIR6812-mediated suppression of mitochondrial genes such as UCP2/PGC-1alpha and reducing profibrotic gene expression (COL3, FN)."	0.8473
36268976	Journal of clinical laboratory analysis	2022	Serum hsa_circ_0000615 is a prognostic biomarker of sorafenib resistance in hepatocellular carcinoma.	hsa_circ_0000615				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"Serum hsa_circ_0000615 is up-regulated in HCC, especially in sorafenib-resistant patients, and higher levels correlate with advanced stage and shorter survival. It shows diagnostic/prognostic utility (ROC) and is proposed as a driver/biomarker of sorafenib resistance."	0.4992
36271413	Biomarker research	2022	Competing endogenous RNA networks related to prognosis in chronic lymphocytic leukemia: comprehensive analyses and construction of a novel risk score model.	hsa_circ_0002078	circ_0002078			chronic lymphocytic leukemia / CLL	MONDO:0003864	chronic lymphocytic leukemia/small lymphocytic lymphoma	up-regulated	RT-qPCR; RNA-seq	"circ_0002078 is up-regulated in CLL patient samples and its high expression is associated with shorter overall survival. Mechanistically, it acts as a ceRNA sponge for miR-185-3p to increase TCF7L1 expression. Functionally, circ_0002078 promotes CLL cell proliferation, suppresses apoptosis, and supports cell-cycle progression."	0.7325
36273140	Cellular & molecular biology letters	2022	circ_0025033 promotes ovarian cancer development via regulating the hsa_miR-370-3p/SLC1A5 axis.	hsa_circ_0025033	circ_0025033	hsa_circ_FOXM1	FOXM1	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circ_0025033 is up-regulated in ovarian cancer and promotes malignant phenotypes (proliferation, invasion, angiogenesis, glutamine metabolism) while suppressing apoptosis. Mechanistically, it functions as a ceRNA by sponging hsa_miR-370-3p to de-repress SLC1A5, and its high expression predicts poor prognosis."	0.8354
36274202	Cell journal	2022	Microarray Profile of Circular RNAs Identifies hsa_circ_0001583 as A New Circular RNA Biomarker for Breast Cancer: A Retrospective Study.	hsa_circ_0001583		hsa_circ_H1-2	H1-2	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	hsa_circ_0001583 is significantly up-regulated in breast cancer tissues and is proposed as a diagnostic biomarker. The study predicts a hsa_circ_0001583_miRNA_mRNA ceRNA network and links it to immune-related pathways by enrichment analysis.	0.4032
36276300	Journal of bone oncology	2022	Silencing of circCYP51A1 represses cell progression and glycolysis by regulating miR-490-3p/KLF12 axis in osteosarcoma under hypoxia.	hsa_circ_0081001	circCYP51A1 / circ_0081001	hsa_circ_CYP51A1		osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circCYP51A1 is up-regulated in osteosarcoma tissues and in osteosarcoma cells exposed to hypoxia. It promotes hypoxia-associated proliferation, migration, invasion and glycolysis by sponging miR-490-3p to upregulate KLF12, and its knockdown suppresses xenograft tumor growth (and reduces lung metastatic nodes)."	0.7855
36276867	Evidence-based complementary and alternative medicine : eCAM	2022	Downregulation of Circ-PITHD1 Suppressed Colorectal Cancer via Glycolysis Inhibition through miR-590-5p/HK2 Axis.	hsa_circ_0010889	circ-PITHD1	hsa_circ_PITHD1	PITHD1	Colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circ-PITHD1 is up-regulated in colorectal cancer tissues and cell lines and promotes proliferation, migration/invasion, tumor growth and lung metastasis. Mechanistically, it acts as a ceRNA by sponging miR-590-5p to increase HK2 expression, thereby enhancing aerobic glycolysis (Warburg effect)."	0.7486
36276964	Frontiers in genetics	2022	Whole-transcriptome sequencing and ceRNA interaction network of temporomandibular joint osteoarthritis.		circRNA1531			temporomandibular joint osteoarthritis / TMJOA	MONDO:0005473	temporomandibular joint disorder	down-regulated	RT-qPCR; RNA-seq	"circRNA1531 is significantly downregulated in rat condylar cartilage in TMJOA (UAC model). It is implicated in a ceRNA axis where circRNA1531 binds miR-9a-5p to regulate Dnmt3a, potentially affecting apoptosis-related cartilage pathology."	0.4997
36276964	Frontiers in genetics	2022	Whole-transcriptome sequencing and ceRNA interaction network of temporomandibular joint osteoarthritis.		ciRNA166 / CircRNA166			temporomandibular joint osteoarthritis / TMJOA	MONDO:0005473	temporomandibular joint disorder	down-regulated	RT-qPCR; RNA-seq	"ciRNA166 is significantly downregulated in rat condylar cartilage in TMJOA. Network analysis suggests it functions through ceRNA axes (ciRNA166/miR-9a-5p/Dnmt3a and possibly miR-26a-5p/Wnk1), potentially influencing apoptosis and Wnt-related processes relevant to cartilage degeneration."	0.4997
36278814	The Kaohsiung journal of medical sciences	2022	circRNA-MSR regulates the expression of FBXO21 to inhibit chondrocyte autophagy by targeting miR-761 in osteoarthritis.		circRNA-MSR			osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circRNA-MSR is up-regulated in osteoarthritis tissues and in an LPS-induced OA-like chondrocyte model. It mainly localizes to the cytoplasm and inhibits chondrocyte autophagy by sponging miR-761, which releases FBXO21 from miR-761-mediated suppression."	0.6824
36279270	PloS one	2022	HSV-1 and influenza infection induce linear and circular splicing of the long NEAT1 isoform.	hsa_circ_0003812	NEAT1_2 circRNA	hsa_circ_NEAT1	NEAT1	HSV-1 infection	MONDO:0005108	viral infectious disease	up-regulated	RNA-seq	"hsa_circ_0003812 is a NEAT1_2-derived circRNA whose biogenesis is strongly induced during HSV-1 infection (vhs-independent) and also during influenza A virus infection. Its induction is linked with novel linear splicing events within and downstream of the circRNA region, suggesting coordinated activation of NEAT1_2 circular and linear splicing under these infection conditions."	0.1768
36279270	PloS one	2022	HSV-1 and influenza infection induce linear and circular splicing of the long NEAT1 isoform.	hsa_circ_0003812	NEAT1_2 circRNA	hsa_circ_NEAT1	NEAT1	influenza A virus infection / IAV infection	MONDO:0005108	viral infectious disease	up-regulated	RNA-seq	"hsa_circ_0003812 is a NEAT1_2-derived circRNA whose biogenesis is strongly induced during HSV-1 infection (vhs-independent) and also during influenza A virus infection. Its induction is linked with novel linear splicing events within and downstream of the circRNA region, suggesting coordinated activation of NEAT1_2 circular and linear splicing under these infection conditions."	0.1768
36279395	Aging	2022	Identification of circRNA-miRNA-mRNA networks to explore the molecular mechanism and immune regulation of postoperative neurocognitive disorder.	mmu_circ_0000331	CIRC0000331 / circ-0000331			postoperative neurocognitive disorder / PND	MONDO:0002602	central nervous system disorder	up-regulated	RT-qPCR; Microarray	"mmu_circ_0000331 is up-regulated in PND mice and was incorporated into ceRNA networks, particularly mmu_circ_0000331/miR-1224-3p/Unc13c (and additional links involving miR-5134-5p with Unc13c/Tbx20). It is proposed as part of regulatory networks related to PND pathogenesis and immune regulation."	0.4997
36279395	Aging	2022	Identification of circRNA-miRNA-mRNA networks to explore the molecular mechanism and immune regulation of postoperative neurocognitive disorder.	mmu_circ_0000406	CIRC0000406 / circ-0000406			postoperative neurocognitive disorder / PND	MONDO:0002602	central nervous system disorder	up-regulated	RT-qPCR; Microarray	mmu_circ_0000406 is up-regulated in PND mice and was prioritized as part of the ceRNA axis mmu_circ_0000406/miR-24-3p/St8sia2. The study proposes this network as potentially involved in PND pathogenesis and immune-related mechanisms.	0.4997
36279395	Aging	2022	Identification of circRNA-miRNA-mRNA networks to explore the molecular mechanism and immune regulation of postoperative neurocognitive disorder.	mmu_circ_0000400	CIRC0000400 / circ-0000400			postoperative neurocognitive disorder / PND	MONDO:0002602	central nervous system disorder	up-regulated	RT-qPCR; Microarray	"mmu_circ_0000400 is up-regulated in PND mice and participates in several predicted ceRNA relationships linking to Unc13c, Tbx20, and St8sia2 via miR-5120, miR-504-3p, and miR-6396. Its inclusion supports a broader circRNA-miRNA-mRNA network potentially relevant to immune regulation in PND."	0.4997
36279395	Aging	2022	Identification of circRNA-miRNA-mRNA networks to explore the molecular mechanism and immune regulation of postoperative neurocognitive disorder.	mmu_circ_0000798	CIRC0000798 / circ-0000798			postoperative neurocognitive disorder / PND	MONDO:0002602	central nervous system disorder	up-regulated	RT-qPCR; Microarray	mmu_circ_0000798 is up-regulated in PND mice and appears in the predicted ceRNA pair mmu_circ_0000798/miR-672-5p/St8sia2. It was validated by qRT-PCR as differentially expressed but not selected as one of the final two focus ceRNA hub networks.	0.4997
36285810	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2022	A Novel Protein Encoded by Exosomal CircATG4B Induces Oxaliplatin Resistance in Colorectal Cancer by Promoting Autophagy.	hsa_circ_0007159	circATG4B / circ_0_007159	hsa_circ_ATG4B	ATG4B	Colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circATG4B is up-regulated in oxaliplatin-resistant CRC (notably enriched in exosomes) and is associated with poorer DFS under oxaliplatin treatment. Mechanistically, circATG4B promotes oxaliplatin resistance by promoting autophagy, largely via encoding circATG4B-222aa that binds TMED10 and relieves TMED10-mediated inhibition of ATG4B."	0.8557
36287121	Non-coding RNA	2022	Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic beta Cells.	hsa_circ_0033184	circWARS / hsa_circRNA_101439	hsa_circ_WARS	WARS	type 1 diabetes mellitus / T1DM	MONDO:0005147	type 1 diabetes mellitus	up-regulated	RT-qPCR; Microarray	"circWARS (hsa_circ_0033184) is strongly induced by pro-inflammatory cytokines in human beta cells and validated by RT-qPCR/Sanger sequencing. It is predicted to bind multiple beta-cell-enriched miRNAs and AGO/RBPs, suggesting a sponge/decoy role within a circWARS_miRNA_mRNA network during cytokine stress relevant to T1D."	0.6193
36287121	Non-coding RNA	2022	Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic beta Cells.	hsa_circ_0000479	circEPSTI1 / hsa_circRNA_000479	hsa_circ_EPSTI1	EPSTI1	type 1 diabetes mellitus / T1DM	MONDO:0005147	type 1 diabetes mellitus	up-regulated	RT-qPCR; Microarray	"circEPSTI1 (hsa_circ_0000479) is upregulated by cytokine exposure in EndoC-betaH1 cells and detected in human islets, with circularity validated by Sanger sequencing. The study¡¯s bioinformatic analysis did not find miRNA binding sites for circEPSTI1, but predicted RBP binding on its junction sequence."	0.6193
36287121	Non-coding RNA	2022	Pro-Inflammatory Cytokines Promote the Transcription of Circular RNAs in Human Pancreatic beta Cells.	hsa_circ_0002938	circCRIM1 / hsa_circRNA_102687	hsa_circ_CRIM1	CRIM1	type 1 diabetes mellitus / T1DM	MONDO:0005147	type 1 diabetes mellitus	up-regulated	RT-qPCR; Microarray	"circCRIM1 (hsa_circ_0002938) is upregulated by cytokines in EndoC-betaH1 cells and validated as circular by RT-qPCR/Sanger sequencing. It is predicted to bind beta-cell-enriched miRNAs (notably the miR-320 family and miR-4429), suggesting a potential sponge/decoy regulatory role during inflammatory stress relevant to T1D."	0.6193
36289463	BMC pediatrics	2022	A potential pathogenic hypoxia-related gene HK2 in necrotizing enterocolitis (NEC) of newborns.	hsa_circ_0001522				Necrotizing enterocolitis / NEC	MONDO:0005313	necrotizing enterocolitis	dysregulated	RNA-seq	hsa_circ_0001522 was identified as a differentially expressed circRNA in NEC tissue and included in a bioinformatically constructed ceRNA network with miR-222-5p/miR-520 g-5p and core mRNAs linked to carbohydrate metabolism and hypoxia-related gene screening (HK2). No experimental validation or functional assays for this specific circRNA were reported beyond RNA-seq and in-silico predictions.	0.1768
36289463	BMC pediatrics	2022	A potential pathogenic hypoxia-related gene HK2 in necrotizing enterocolitis (NEC) of newborns.	hsa_circ_0000690				Necrotizing enterocolitis / NEC	MONDO:0005313	necrotizing enterocolitis	dysregulated	RNA-seq	"hsa_circ_0000690 was included as a differentially expressed circRNA in NEC and incorporated into a predicted ceRNA network with miR-222-5p/miR-520 g-5p and core mRNAs used to prioritize HK2 as a hypoxia- and carbohydrate-metabolism-related gene. Evidence is limited to RNA-seq differential expression plus bioinformatics target prediction/cross analysis, without experimental validation for this circRNA."	0.1768
36289463	BMC pediatrics	2022	A potential pathogenic hypoxia-related gene HK2 in necrotizing enterocolitis (NEC) of newborns.	hsa_circ_0001772				Necrotizing enterocolitis / NEC	MONDO:0005313	necrotizing enterocolitis	dysregulated	RNA-seq	hsa_circ_0001772 was reported as a differentially expressed circRNA in NEC and was included in the predicted key ceRNA regulatory network alongside miR-222-5p/miR-520 g-5p and 20 core mRNAs leading to prioritization of HK2. The study did not provide circRNA-specific experimental validation beyond RNA-seq and bioinformatics analyses.	0.1768
36289463	BMC pediatrics	2022	A potential pathogenic hypoxia-related gene HK2 in necrotizing enterocolitis (NEC) of newborns.	hsa_circ_0004273				Necrotizing enterocolitis / NEC	MONDO:0005313	necrotizing enterocolitis	dysregulated	RNA-seq	hsa_circ_0004273 was identified among differentially expressed circRNAs in NEC and was incorporated into the study¡¯s key predicted ceRNA network involving miR-222-5p/miR-520 g-5p and core mRNAs that guided selection of HK2 as a candidate pathogenic hypoxia-related gene. No circRNA-specific wet-lab validation was provided for hsa_circ_0004273.	0.1768
36289681	Biomedicines	2022	Association of Circular RNA and Long Non-Coding RNA Dysregulation with the Clinical Response to Immune Checkpoint Blockade in Cutaneous Metastatic Melanoma.		CDR1-AS / hsa-CDR1	hsa_circ_CDR1	CDR1	cutaneous melanoma	MONDO:0005012	cutaneous melanoma	up-regulated	RT-qPCR; RNA-seq	"CDR1-AS (hsa-CDR1_0001) is differentially expressed between nivolumab responders and non-responders in cutaneous metastatic melanoma and is highlighted as a potential biomarker of ICB response. The study supports a putative ceRNA role for this circRNA, consistent with miRNA sponge activity (including miRNA-7, per prior knowledge), within immune-response regulatory networks."	0.4032
36297470	Pharmaceutics	2022	Multiplex Analysis of CircRNAs from Plasma Extracellular Vesicle-Enriched Samples for the Detection of Early-Stage Non-Small Cell Lung Cancer.		circEPB41L2	hsa_circ_EPB41L2	EPB41L2	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	Others	circEPB41L2 is significantly up-regulated in plasma EV-enriched samples from early-stage NSCLC patients compared with non-cancer controls and is included in a 10-circRNA machine-learning signature that discriminates cancer from controls.	0.0693
36297470	Pharmaceutics	2022	Multiplex Analysis of CircRNAs from Plasma Extracellular Vesicle-Enriched Samples for the Detection of Early-Stage Non-Small Cell Lung Cancer.		circC1GALT1	hsa_circ_C1GALT1	C1GALT1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	Others	circC1GALT1 is significantly up-regulated in plasma EV-enriched samples from early-stage NSCLC patients compared with non-cancer controls based on nCounter differential expression analysis.	0.0693
36297470	Pharmaceutics	2022	Multiplex Analysis of CircRNAs from Plasma Extracellular Vesicle-Enriched Samples for the Detection of Early-Stage Non-Small Cell Lung Cancer.		circZFR	hsa_circ_ZFR	ZFR	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	Others	circZFR is significantly up-regulated in plasma EV-enriched samples from early-stage NSCLC patients compared with non-cancer controls based on nCounter differential expression analysis.	0.0693
36297470	Pharmaceutics	2022	Multiplex Analysis of CircRNAs from Plasma Extracellular Vesicle-Enriched Samples for the Detection of Early-Stage Non-Small Cell Lung Cancer.		circUSP3	hsa_circ_USP3	USP3	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	Others	circUSP3 is significantly up-regulated in plasma EV-enriched samples from early-stage NSCLC patients compared with non-cancer controls based on nCounter differential expression analysis.	0.0693
36297470	Pharmaceutics	2022	Multiplex Analysis of CircRNAs from Plasma Extracellular Vesicle-Enriched Samples for the Detection of Early-Stage Non-Small Cell Lung Cancer.		circZCCHC6	hsa_circ_ZCCHC6	ZCCHC6	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	circZCCHC6 is up-regulated in plasma EV-enriched samples from early-stage NSCLC patients and was experimentally validated by RT-qPCR with divergent primers and junction confirmation by Sanger sequencing. It is also included in a 10-circRNA machine-learning signature (AUC ROC 0.86) for discriminating NSCLC from controls; the paper notes reported/putative miRNA interactions and a previously described circZCCHC6_miR-433-3p_LPCAT1 regulatory relationship.	0.6548
36297470	Pharmaceutics	2022	Multiplex Analysis of CircRNAs from Plasma Extracellular Vesicle-Enriched Samples for the Detection of Early-Stage Non-Small Cell Lung Cancer.		circCCNB1 / circular Cyclin B1	hsa_circ_CCNB1	CCNB1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	Others	circCCNB1 is significantly up-regulated in plasma EV-enriched samples from early-stage NSCLC patients compared with non-cancer controls based on nCounter differential expression analysis.	0.0693
36297470	Pharmaceutics	2022	Multiplex Analysis of CircRNAs from Plasma Extracellular Vesicle-Enriched Samples for the Detection of Early-Stage Non-Small Cell Lung Cancer.		circDENN1B / circular DENN Domain Containing 1B	hsa_circ_DENN1B	DENN1B	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	Others	circDENN1B is significantly up-regulated in plasma EV-enriched samples from early-stage NSCLC patients compared with non-cancer controls based on nCounter differential expression analysis.	0.0693
36297470	Pharmaceutics	2022	Multiplex Analysis of CircRNAs from Plasma Extracellular Vesicle-Enriched Samples for the Detection of Early-Stage Non-Small Cell Lung Cancer.		circHIPK3 / circular Homeodomain Interacting Protein Kinase 3	hsa_circ_HIPK3	HIPK3	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	circHIPK3 is up-regulated in plasma EV-enriched samples from early-stage NSCLC patients and its expression/junction was validated by RT-qPCR with divergent primers and Sanger sequencing. The article contextualizes circHIPK3 as acting via miR-149 and mir-124 and being associated with increased proliferation and reduced apoptosis in lung cancer.	0.5841
36297470	Pharmaceutics	2022	Multiplex Analysis of CircRNAs from Plasma Extracellular Vesicle-Enriched Samples for the Detection of Early-Stage Non-Small Cell Lung Cancer.		circFAM13B / circular Family With Sequence Similarity 13 Member B	hsa_circ_FAM13B	FAM13B	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	unknown	Others	circFAM13B is part of a plasma EV-circRNA 10-feature machine-learning signature that discriminates early-stage NSCLC from non-cancer controls with AUC ROC 0.86; direction of differential expression for this individual circRNA was not reported.	0.2629
36297470	Pharmaceutics	2022	Multiplex Analysis of CircRNAs from Plasma Extracellular Vesicle-Enriched Samples for the Detection of Early-Stage Non-Small Cell Lung Cancer.		circADAM22 / circular ADAM Metallopeptidase Domain 22	hsa_circ_ADAM22	ADAM22	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	unknown	Others	circADAM22 is part of a plasma EV-circRNA 10-feature machine-learning signature that discriminates early-stage NSCLC from non-cancer controls with AUC ROC 0.86; direction of differential expression for this individual circRNA was not reported.	0.2629
36297470	Pharmaceutics	2022	Multiplex Analysis of CircRNAs from Plasma Extracellular Vesicle-Enriched Samples for the Detection of Early-Stage Non-Small Cell Lung Cancer.		circUBXN7 / circular UBX Domain Protein 7	hsa_circ_UBXN7	UBXN7	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	unknown	Others	circUBXN7 is part of a plasma EV-circRNA 10-feature machine-learning signature that discriminates early-stage NSCLC from non-cancer controls with AUC ROC 0.86; direction of differential expression for this individual circRNA was not reported.	0.2629
36297470	Pharmaceutics	2022	Multiplex Analysis of CircRNAs from Plasma Extracellular Vesicle-Enriched Samples for the Detection of Early-Stage Non-Small Cell Lung Cancer.		circITGAX / circular Integrin Subunit Alpha X	hsa_circ_ITGAX	ITGAX	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	unknown	Others	circITGAX is part of a plasma EV-circRNA 10-feature machine-learning signature that discriminates early-stage NSCLC from non-cancer controls with AUC ROC 0.86; direction of differential expression for this individual circRNA was not reported.	0.2629
36297470	Pharmaceutics	2022	Multiplex Analysis of CircRNAs from Plasma Extracellular Vesicle-Enriched Samples for the Detection of Early-Stage Non-Small Cell Lung Cancer.		circRDH11 / circular Retinol Dehydrogenase 11	hsa_circ_RDH11	RDH11	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	unknown	Others	circRDH11 is part of a plasma EV-circRNA 10-feature machine-learning signature that discriminates early-stage NSCLC from non-cancer controls with AUC ROC 0.86; direction of differential expression for this individual circRNA was not reported.	0.2629
36297470	Pharmaceutics	2022	Multiplex Analysis of CircRNAs from Plasma Extracellular Vesicle-Enriched Samples for the Detection of Early-Stage Non-Small Cell Lung Cancer.		circCLK1 / circular CDC Like Kinase 1	hsa_circ_CLK1	CLK1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	unknown	Others	circCLK1 is part of a plasma EV-circRNA 10-feature machine-learning signature that discriminates early-stage NSCLC from non-cancer controls with AUC ROC 0.86; direction of differential expression for this individual circRNA was not reported.	0.2629
36297470	Pharmaceutics	2022	Multiplex Analysis of CircRNAs from Plasma Extracellular Vesicle-Enriched Samples for the Detection of Early-Stage Non-Small Cell Lung Cancer.		circFARSA / circular Phenylalanyl-tRNA Synthetase Subunit Alpha	hsa_circ_FARSA	FARSA	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	unknown	Others	"circFARSA is part of a plasma EV-circRNA 10-feature machine-learning signature for early-stage NSCLC detection (AUC ROC 0.86). The paper does not report its expression direction in this cohort, but notes prior evidence that circFARSA promotes invasion and metastasis via the PTEN/PI3K/AKT axis."	0.2629
36297470	Pharmaceutics	2022	Multiplex Analysis of CircRNAs from Plasma Extracellular Vesicle-Enriched Samples for the Detection of Early-Stage Non-Small Cell Lung Cancer.		circPIK3R1 / circular Phosphoinositide-3-Kinase Regulatory Subunit 1	hsa_circ_PIK3R1	PIK3R1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	unknown	Others	circPIK3R1 is part of a plasma EV-circRNA 10-feature machine-learning signature that discriminates early-stage NSCLC from non-cancer controls with AUC ROC 0.86; direction of differential expression for this individual circRNA was not reported.	0.2629
36299308	Journal of dental sciences	2022	The circular RNA circ_0099630/miR-940/receptor-associated factor 6 regulation cascade modulates the pathogenesis of periodontitis.	hsa_circ_0099630	circ_0099630			periodontitis	MONDO:0005076	periodontitis	up-regulated	RT-qPCR	"circ_0099630 is up-regulated in periodontitis tissues and LPS-induced PDLCs and correlates with disease severity. It aggravates inflammatory injury by sponging miR-940 to increase TRAF6 and activate NF-kappaB signaling; silencing circ_0099630 reduces IL-6/TNF-alpha, decreases apoptosis, and restores PDLC viability/proliferation."	0.7412
36300085	Frontiers in oncology	2022	"Identification of a dysregulated CircRNA-associated gene signature for predicting prognosis, immune landscape, and drug candidates in bladder cancer."	hsa_circ_0001681	circ_0001681			bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ_0001681 was identified as differentially expressed and up-regulated in bladder cancer tissues versus paracancerous tissues, and its altered expression was confirmed by RT-qPCR in 20 paired clinical samples."	0.4032
36300085	Frontiers in oncology	2022	"Identification of a dysregulated CircRNA-associated gene signature for predicting prognosis, immune landscape, and drug candidates in bladder cancer."	hsa_circ_0000643	circ_0000643			bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	circ_0000643 was identified as a down-regulated circRNA in bladder cancer and its differential expression was validated by RT-qPCR in 20 paired tumor/paracancerous tissues.	0.4032
36300085	Frontiers in oncology	2022	"Identification of a dysregulated CircRNA-associated gene signature for predicting prognosis, immune landscape, and drug candidates in bladder cancer."	hsa_circ_0001798	circ_0001798			bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"circ_0001798 was identified as down-regulated in bladder cancer, and its differential expression was confirmed by RT-qPCR in paired clinical tissues."	0.4032
36300085	Frontiers in oncology	2022	"Identification of a dysregulated CircRNA-associated gene signature for predicting prognosis, immune landscape, and drug candidates in bladder cancer."	hsa_circ_0006117	circ_0006117			bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"circ_0006117 was identified as down-regulated in bladder cancer, and its differential expression was confirmed by RT-qPCR in paired clinical tissues."	0.4032
36300085	Frontiers in oncology	2022	"Identification of a dysregulated CircRNA-associated gene signature for predicting prognosis, immune landscape, and drug candidates in bladder cancer."	hsa_circ_0067900	circ_0067900			bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"circ_0067900 (also written as has_circ_0067900/hsa_circ_0067900) is down-regulated in bladder cancer tissues. Its overexpression in T24 and 253J-BV cells suppresses proliferation, migration, and invasion, supporting a tumor-suppressive role in BCa."	0.7283
36302650	Life science alliance	2023	circEXOC5 promotes acute lung injury through the PTBP1/Skp2/Runx2 axis to activate autophagy.	hsa_circ_0004399	circEXOC5	hsa_circ_EXOC5	EXOC5	acute lung injury / ALI	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR	"circEXOC5 is up-regulated in CLP-induced ALI lungs and in LPS-challenged MPVECs and promotes inflammatory injury by activating autophagy. Mechanistically, circEXOC5 interacts with PTBP1 to accelerate Skp2 mRNA decay, which reduces Skp2-dependent ubiquitination of Runx2, increases Runx2, and aggravates ALI phenotypes."	0.774
36302650	Life science alliance	2023	circEXOC5 promotes acute lung injury through the PTBP1/Skp2/Runx2 axis to activate autophagy.		circEXOC5	mmu_circ_EXOC5	EXOC5	acute lung injury / ALI	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR	"circEXOC5 is up-regulated in CLP-induced ALI lungs and in LPS-challenged MPVECs and promotes inflammatory injury by activating autophagy. Mechanistically, circEXOC5 interacts with PTBP1 to accelerate Skp2 mRNA decay, which reduces Skp2-dependent ubiquitination of Runx2, increases Runx2, and aggravates ALI phenotypes."	0.774
36304901	Frontiers in bioengineering and biotechnology	2022	Hsa_circ_0008870 suppresses bone formation of growth plate through inhibition of miR-185-3p/ MAPK1 axis in idiopathic short stature.	hsa_circ_0008870	circ-0008870			idiopathic short stature / ISS	MONDO:1010112	isolated short stature	down-regulated	RT-qPCR; Microarray	"In ISS, hsa_circ_0008870 is down-regulated in peripheral blood and functions as a cytoplasmic ceRNA that sponges miR-185-3p to maintain MAPK1 expression. Loss of hsa_circ_0008870 suppresses chondrocyte proliferation/hypertrophy and endochondral ossification in vitro and reduces growth plate bone formation in vivo, contributing to a short-stature phenotype."	0.7519
36305048	Journal of clinical laboratory analysis	2022	"Hsa_circ_0005529 promotes ZEB1 expression by regulating miR-873-5p and enhancing proliferation, invasion, and migration in gastric cancer cell lines."	hsa_circ_0005529				gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0005529 is up-regulated in gastric cancer tissues and GC cell lines and mainly localizes to the cytoplasm. It promotes proliferation, migration, and invasion by sponging miR-873-5p and thereby increasing ZEB1 expression via a hsa_circ_0005529/miR-873-5p/ZEB1 axis."	0.7519
36306106	Journal of endocrinological investigation	2023	CircNDST1 promotes papillary thyroid cancer progression via its interaction with CSNK2A1 to activate the PI3K-Akt pathway and epithelial-mesenchymal transition.	hsa_circ_0006943	circNDST1	hsa_circ_NDST1	NDST1	papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; RNA-seq	"circNDST1 (hsa_circ_0006943), derived from NDST1, is up-regulated in papillary thyroid cancer cell lines and promotes tumor cell proliferation, migration, invasion, and EMT. Mechanistically, it binds CSNK2A1 and enhances CSNK2A1_Akt interaction to activate PI3K/AKT signaling (with downstream effects including CCND1/PTEN pathway changes)."	0.82
36313671	Frontiers in oncology	2022	CircHADHA-augmented autophagy suppresses tumor growth of colon cancer by regulating autophagy-related gene via miR-361.	hsa_circ_0053063	circRNA HADHA / circ_0053063	hsa_circ_HADHA	HADHA	colon cancer	MONDO:0021063	malignant colon neoplasm	down-regulated	RT-qPCR; Microarray	"CircHADHA (from host gene HADHA) shows dynamic plasma changes across healthy, colon polyp, and colon cancer groups, and is reduced in colon cancer vs polyp. Mechanistically, circHADHA functions as a miRNA sponge (notably miR-361) to increase ATG13, thereby promoting autophagy and suppressing proliferation and xenograft tumor growth in colon cancer cells."	0.7954
36316334	Nature communications	2022	Circular RNA circBNC2 inhibits epithelial cell G2-M arrest to prevent fibrotic maladaptive repair.		circBNC2	hsa_circ_BNC2	BNC2	kidney fibrosis / renal fibrosis	MONDO:0000494	renal fibrosis	down-regulated	RT-qPCR; Northern Blot; ISH; RNA-seq	"circBNC2 is downregulated in kidney and liver fibrotic injury settings. It suppresses epithelial G2/M arrest and profibrotic factor secretion by encoding ctBNC2, which promotes CDK1/cyclin B1 complex formation and supports mitotic entry, thereby mitigating maladaptive repair and fibrosis."	0.8741
36316334	Nature communications	2022	Circular RNA circBNC2 inhibits epithelial cell G2-M arrest to prevent fibrotic maladaptive repair.		circBNC2	mmu_circ_BNC2	BNC2	kidney fibrosis / renal fibrosis	MONDO:0000494	renal fibrosis	down-regulated	RT-qPCR; Northern Blot; ISH; RNA-seq	"circBNC2 is downregulated in kidney and liver fibrotic injury settings. It suppresses epithelial G2/M arrest and profibrotic factor secretion by encoding ctBNC2, which promotes CDK1/cyclin B1 complex formation and supports mitotic entry, thereby mitigating maladaptive repair and fibrosis."	0.8741
36326248	The Kaohsiung journal of medical sciences	2023	CircUCK2 regulates HECTD1-mediated endothelial-mesenchymal transition inhibition by interacting with FUS and protects the blood-brain barrier in ischemic stroke.		CircUCK2	mmu_circ_UCK2	UCK2	ischemic stroke / IS	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR	"circUCK2 is down-regulated in ischemic stroke models (tMCAO brain tissue and OGD/R-treated bEnd.3 cells). Its overexpression protects BBB integrity by inhibiting EndoMT, mechanistically through binding the RBP FUS to increase HECTD1 mRNA stability and upregulate HECTD1."	0.6865
36328987	"Cancer communications (London, England)"	2023	circCAPRIN1 interacts with STAT2 to promote tumor progression and lipid synthesis via upregulating ACC1 expression in colorectal cancer.	hsa_circ_0021639	circCAPRIN1	hsa_circ_CAPRIN1	CAPRIN1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; Microarray	"circCAPRIN1 (hsa_circ_0021639) is up-regulated in colorectal cancer and promotes proliferation, migration, EMT, tumor growth and metastasis. Mechanistically, it localizes mainly to the nucleus and binds STAT2 to enhance ACC1 transcription, driving ACC1-dependent lipid synthesis. High circCAPRIN1 expression is associated with advanced stage and worse OS/DFS."	0.8869
36329387	Clinical proteomics	2022	Identification of circular RNA BTBD7_hsa_circ_0000563 as a novel biomarker for coronary artery disease and the functional discovery of BTBD7_hsa_circ_0000563 based on peripheral blood mononuclear cells: a case control study.	hsa_circ_0000563		hsa_circ_BTBD7	BTBD7	coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	down-regulated	RT-qPCR	"BTBD7_hsa_circ_0000563 is down-regulated in PBMCs from CAD patients and shows diagnostic value for CAD. It directly binds several RBPs (e.g., UBB/UBC/RPS27A/UBA52/CTSD/ARG1/PCCA), and enrichment analyses of these partners implicate mitophagy and DNA repair-related processes, suggesting a circRNA_RBP mechanism in CAD."	0.6846
36329956	Cardiovascular diagnosis and therapy	2022	CircHSPG2 absence weakens hypoxia-induced dysfunction in cardiomyocytes by targeting the miR-25-3p/PAWR axis.	hsa_circ_0010729	circHSPG2	hsa_circ_HSPG2	HSPG2	myocardial infarction / MI	MONDO:0005068	myocardial infarction	up-regulated	RT-qPCR	"In hypoxia-treated human cardiomyocytes (AC-16), circHSPG2 is up-regulated and contributes to reduced viability/proliferation and increased apoptosis/cell death. Mechanistically, circHSPG2 sponges miR-25-3p to de-repress/positively regulate PAWR, forming a circHSPG2/miR-25-3p/PAWR axis; circHSPG2 silencing is protective."	0.7221
36334805	Life sciences	2023	CircRAD54L2 promotes triple-negative breast cancer progression by regulating the miR-888 family/PDK1 axis.	hsa_circ_0001306	circRAD54L2	hsa_circ_RAD54L2	RAD54L2	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"circRAD54L2 (hsa_circ_0001306), derived from RAD54L2 exons 1-4, is up-regulated in breast cancer/TNBC cell lines. It promotes proliferation, migration, invasion and metastasis by sponging the miR-888 family (hsa-miR-888/miR-890/miR-892a/miR-892b) to derepress PDK1 in a ceRNA manner."	0.8118
36335337	Journal of translational medicine	2022	Lymphatic metastasis-associated circRNA_miRNA_mRNA network for exploring the pathogenesis and therapeutic target of triple negative breast cancer based on whole-transcriptome sequencing analysis: an experimental verification study.	hsa_circ_0061260	hsa_circRNA_061260			triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0061260 was identified from WTS-based differential expression and ceRNA network analysis related to ALN metastasis in TNBC. It is proposed to act as a ceRNA by binding hsa-miR-5000-3p and thereby relating to EDARADD regulation, and its expression was validated as downregulated in TNBC cell lines versus MCF-10A."	0.6521
36335337	Journal of translational medicine	2022	Lymphatic metastasis-associated circRNA_miRNA_mRNA network for exploring the pathogenesis and therapeutic target of triple negative breast cancer based on whole-transcriptome sequencing analysis: an experimental verification study.	hsa_circ_0060876	hsa_circRNA_060876			triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0060876 was identified from WTS-based differential expression and incorporated into a survival-related ceRNA network for ALN metastasis in TNBC. It is proposed to sponge hsa-miR-4792 and connect to GSR and RAB3D in ceRNA axes, and it was validated as downregulated in TNBC cell lines versus MCF-10A."	0.585
36338034	Frontiers in microbiology	2022	CircDDX17 enhances coxsackievirus B3 replication through regulating miR-1248/NOTCH receptor 2 axis.	hsa_circ_0063331	circDDX17	hsa_circ_DDX17	DDX17	viral myocarditis / VM	MONDO:0023161	viral myocarditis	down-regulated	RT-qPCR; Microarray	"circDDX17 (hsa_circ_0063331), derived from DDX17, is down-regulated after CVB3 infection in cells and in a mouse viral myocarditis model. Functionally, circDDX17 promotes CVB3 replication by sponging miR-1248 to relieve repression of NOTCH2, which is linked to increased METTL3/METTL14 expression."	0.7924
36338954	Frontiers in genetics	2022	Predicting the influence of Circ_0059706 expression on prognosis in patients with acute myeloid leukemia using classical statistics and machine learning.	hsa_circ_0059706	circ_0059706	hsa_circ_ID1	ID1	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	down-regulated	RT-qPCR	"circ_0059706 (ID1-derived) is down-regulated in de novo AML bone marrow and shows diagnostic potential. Higher circ_0059706 expression correlates with longer overall survival and in vitro overexpression suppresses leukemia cell growth while increasing apoptosis. A miR-326 binding site is predicted, suggesting a possible circRNA/miRNA mechanism, but it is not experimentally validated."	0.6667
36339002	Frontiers in genetics	2022	Hsa_circ_0040809 and hsa_circ_0000467 promote colorectal cancer cells progression and construction of a circRNA-miRNA-mRNA network.	hsa_circ_0040809	hsa_circRNA_101900	hsa_circ_BANP	BANP	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0040809 is up-regulated in CRC tissues and cell lines and promotes CRC cell proliferation and migration. The study proposes a ceRNA axis in which hsa_circ_0040809 is linked to miR-330-3p and RUNX1, supported by expression changes after circRNA knockdown."	0.5923
36339002	Frontiers in genetics	2022	Hsa_circ_0040809 and hsa_circ_0000467 promote colorectal cancer cells progression and construction of a circRNA-miRNA-mRNA network.	hsa_circ_0000467	hsa_circRNA_101231	hsa_circ_SKA3	SKA3	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000467 is up-regulated in CRC tissues and cell lines and promotes CRC cell proliferation and migration. The study proposes that hsa_circ_0000467 may function in a ceRNA network involving miR-326/miR-330-5p and the target gene FADS1, supported by expression changes after circRNA knockdown."	0.5923
36339005	Frontiers in genetics	2022	Predicting protective gene biomarker of acute coronary syndrome by the circRNA-associated competitive endogenous RNA regulatory network.	hsa_circ_0082319				acute coronary syndrome / ACS	MONDO:0005542	acute coronary syndrome	down-regulated	Microarray	"hsa_circ_0082319 is downregulated in ACS and was included in a circRNA_miRNA_mRNA ceRNA network. It is predicted to sponge hsa-miR-583/hsa-miR-661/hsa-miR-671-5p/hsa-miR-578, thereby affecting expression/activity of XPNPEP1, UCHL1, DBNL, GPC6 and RAD51 in ACS."	0.1768
36339005	Frontiers in genetics	2022	Predicting protective gene biomarker of acute coronary syndrome by the circRNA-associated competitive endogenous RNA regulatory network.	hsa_circ_0005654				acute coronary syndrome / ACS	MONDO:0005542	acute coronary syndrome	down-regulated	Microarray	"hsa_circ_0005654 is downregulated in ACS and was included in a circRNA_miRNA_mRNA ceRNA network. It is predicted to sponge hsa-miR-583/hsa-miR-661/hsa-miR-671-5p/hsa-miR-578, thereby affecting expression/activity of XPNPEP1, UCHL1, DBNL, GPC6 and RAD51 in ACS."	0.1768
36339585	Frontiers in pharmacology	2022	Potential predictive and therapeutic applications of small extracellular vesicles-derived circPARD3B in osteoarthritis.	hsa_circ_0008172	circPARD3B	hsa_circ_PARD3B	PARD3B	osteoarthritis / OA	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR	"hsa_circ_0008172 (circPARD3B) is decreased in OA inflammatory phenotype (synovitis-high) serum sEV and is also down-regulated in OA synovial tissue. Functionally, circPARD3B suppresses VEGF-driven angiogenesis and OA progression by sponging miR-326 to increase SIRT1, leading to reduced VEGF (and MMP13) levels; engineered circPARD3B-overexpressing SMSCs-sEV further ameliorates collagenase-induced OA in vivo."	0.817
36339941	Journal of immunology research	2022	Differential Expression and Bioinformatics Analysis of Plasma-Derived Exosomal circRNA in Type 1 Diabetes Mellitus.	hsa_circ_0005630				type 1 diabetes mellitus / T1DM	MONDO:0005147	type 1 diabetes mellitus	unknown	RNA-seq	This study identified hsa_circ0005630 as a differentially expressed plasma-derived exosomal circRNA in T1DM and proposed a predicted ceRNA axis involving miR-1247-5p and the target genes ATXN1/ARL6IP1 that might relate to T1DM progression.	0.2414
36339941	Journal of immunology research	2022	Differential Expression and Bioinformatics Analysis of Plasma-Derived Exosomal circRNA in Type 1 Diabetes Mellitus.	hsa_circ_0007026				type 1 diabetes mellitus / T1DM	MONDO:0005147	type 1 diabetes mellitus	unknown	RNA-seq	This study identified hsa_circ0007026 as a differentially expressed plasma-derived exosomal circRNA in T1DM and proposed a predicted ceRNA axis involving miR-324-5p and the target genes NCAPD2/PGAM1 that might relate to T1DM progression.	0.2414
36340580	Disease markers	2022	Hsa_circ_0097271 Knockdown Attenuates Osteosarcoma Progression via Regulating miR-640/MCAM Pathway.	hsa_circ_0097271	circ_0097271	hsa_circ_ATP2A2	ATP2A2	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ_0097271 is up-regulated in osteosarcoma tissues and cell lines and mainly localized in the cytoplasm. Its knockdown inhibits proliferation and migration in vitro and suppresses xenograft tumor growth in vivo, at least partly by sponging miR-640 to de-repress the downstream target MCAM."	0.8025
36341343	Frontiers in immunology	2022	Immune-associated pivotal biomarkers identification and competing endogenous RNA network construction in post-operative atrial fibrillation by comprehensive bioinformatics and machine learning strategies.	hsa_circ_0007738	circ_0007738			post-operative atrial fibrillation / POAF	MONDO:0004981	atrial fibrillation	down-regulated	Microarray	circ_0007738 is significantly down-regulated in POAF plasma samples and was the only circRNA retained to build a predicted ceRNA network linking it to immune-associated hub genes via miRNAs. Its functional mechanism is computationally inferred and requires further experimental validation.	0.1768
36344492	Cell death & disease	2022	CircFOXO3 protects against osteoarthritis by targeting its parental gene FOXO3 and activating PI3K/AKT-mediated autophagy.	mmu_circ_0002207	CircFOXO3	mmu_circ_FOXO3	FOXO3	Osteoarthritis / OA	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR; ISH	"circFOXO3 is down-regulated in osteoarthritic cartilage and inflammatory (IL-1beta) conditions. It protects chondrocytes by interacting with its host gene FOXO3 and enhancing autophagy via inhibition of PI3K/AKT signaling, thereby reducing apoptosis and ECM catabolism; intra-articular lentiviral circFOXO3 alleviates OA in a DMM mouse model."	0.7827
36348379	Experimental hematology & oncology	2022	circRanGAP1/miR-27b-3p/NRAS Axis may promote the progression of hepatocellular Carcinoma.	hsa_circ_0063513	circRanGAP1 / circ_0063513	hsa_circ_RanGAP1	RanGAP1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circRanGAP1 (hsa_circ_0063513), derived from RanGAP1, is up-regulated in HCC tissues and cell lines and promotes HCC proliferation, migration, invasion, and in vivo tumor growth/metastasis. It mainly localizes to the cytoplasm and functions as a miR-27b-3p sponge to upregulate NRAS and activate ERK/MAPK signaling, and is linked to increased tumor-associated macrophage infiltration."	0.8512
36350973	Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas	2022	Whole blood circular RNA hsa_circ_0002171 serves as a potential diagnostic biomarker for human adenovirus pneumonia in children.	hsa_circ_0002171				adenovirus pneumonia	MONDO:0043479	adenoviridae infectious disease	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0002171 is up-regulated in whole blood of children with HAdV pneumonia versus healthy controls, and further increased in severe versus mild cases. It shows diagnostic value by ROC analysis and correlates positively with disease severity, but its detailed biological mechanism was not experimentally defined."	0.5047
36352482	European journal of medical research	2022	"Circular RNA hsa_circ_0023404 promotes the proliferation, migration and invasion in endometrial cancer cells through regulating miR-217/MAPK1 axis."	hsa_circ_0023404	circ_0023404	hsa_circ_RNF121	RNF121	endometrial cancer / EC	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR	"hsa_circ_0023404 is up-regulated in endometrial cancer cell lines and promotes proliferation, migration, and invasion. Mechanistically, it acts as a ceRNA that sponges miR-217, leading to increased MARK1 expression and enhanced malignant phenotypes in vitro."	0.421
36354693	"Current oncology (Toronto, Ont.)"	2022	"CircRNA-Based Cervical Cancer Prognosis Model, Immunological Validation and Drug Prediction."	hsa_circ_0101996	circRNA_101996	hsa_circ_SOS2	SOS2	cervical cancer / CC	MONDO:0002974	cervical cancer	unknown	Microarray	"This study highlighted hsa_circ_0101996 (circRNA_101996) as a key circRNA within an inferred CC ceRNA network, acting as a putative miRNA sponge. It is derived from the host gene SOS2 and was prioritized due to an ¡°up-down-up¡± circRNA_miRNA_mRNA expression pattern, suggesting a potentially important regulatory role worth further validation."	0.1768
36354693	"Current oncology (Toronto, Ont.)"	2022	"CircRNA-Based Cervical Cancer Prognosis Model, Immunological Validation and Drug Prediction."	hsa_circ_0101308				cervical cancer / CC	MONDO:0002974	cervical cancer	unknown	Microarray	"hsa_circ_0101308 was included as one of five circRNAs in the study¡¯s CC ceRNA network and was modeled as a putative miRNA sponge regulating downstream mRNAs. No circRNA-specific expression direction, miRNA partners, or functional validation was reported for this circRNA."	0.1768
36354693	"Current oncology (Toronto, Ont.)"	2022	"CircRNA-Based Cervical Cancer Prognosis Model, Immunological Validation and Drug Prediction."	hsa_circ_0102050				cervical cancer / CC	MONDO:0002974	cervical cancer	unknown	Microarray	"hsa_circ_0102050 was included as one of five circRNAs in the study¡¯s CC ceRNA network and was modeled as a putative miRNA sponge regulating downstream mRNAs. No circRNA-specific expression direction, miRNA partners, or functional validation was reported for this circRNA."	0.1768
36354693	"Current oncology (Toronto, Ont.)"	2022	"CircRNA-Based Cervical Cancer Prognosis Model, Immunological Validation and Drug Prediction."	hsa_circ_0102031				cervical cancer / CC	MONDO:0002974	cervical cancer	unknown	Microarray	"hsa_circ_0102031 was included as one of five circRNAs in the study¡¯s CC ceRNA network and was modeled as a putative miRNA sponge regulating downstream mRNAs. No circRNA-specific expression direction, miRNA partners, or functional validation was reported for this circRNA."	0.1768
36354693	"Current oncology (Toronto, Ont.)"	2022	"CircRNA-Based Cervical Cancer Prognosis Model, Immunological Validation and Drug Prediction."	hsa_circ_0103677				cervical cancer / CC	MONDO:0002974	cervical cancer	unknown	Microarray	"hsa_circ_0103677 was included as one of five circRNAs in the study¡¯s CC ceRNA network and was modeled as a putative miRNA sponge regulating downstream mRNAs. No circRNA-specific expression direction, miRNA partners, or functional validation was reported for this circRNA."	0.1768
36359856	Cells	2022	PRP8-Induced CircMaml2 Facilitates the Healing of the Intestinal Mucosa via Recruiting PTBP1 and Regulating Sec62.		circMaml2	mmu_circ_Maml2	Maml2	intestinal mucosal injury	MONDO:0021178	injury	down-regulated	RT-qPCR; Microarray	"In severe-burn intestinal mucosal injury (mouse), circMaml2 is down-regulated and its overexpression promotes intestinal epithelial proliferation/migration and mucosal repair. Mechanistically, circMaml2 binds the RBP PTBP1 to enhance Ebf1 expression (via increased mRNA stability) and sponges miR-683 to relieve repression of Sec62; PRP8 promotes circMaml2 biogenesis."	0.7769
36360223	Genes	2022	Deregulated Expression of Circular RNAs Is Associated with Immune Evasion and Leukemia Relapse after Allogeneic Hematopoietic Stem Cell Transplantation.	hsa_circ_0012152	circRNF220	hsa_circ_RNF220	RNF220	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; RNA-seq	Hsa_circ_0012152 (circRNF220) is up-regulated in relapsed AML blasts after allo-HSCT and is implicated in immune evasion. It may function as a ceRNA by sponging miR-92a-1-5p to increase PVR expression.	0.4032
36360223	Genes	2022	Deregulated Expression of Circular RNAs Is Associated with Immune Evasion and Leukemia Relapse after Allogeneic Hematopoietic Stem Cell Transplantation.	hsa_circ_0002768	circMYLK	hsa_circ_MYLK	MYLK	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	down-regulated	RT-qPCR; RNA-seq	"In relapsed AML after allo-HSCT, hsa_circ_0002768 (circMYLK) is down-regulated and is linked to immune evasion. The study associates circMYLK downregulation with reduced expression of the HLA class II regulator CIITA."	0.4032
36362022	International journal of molecular sciences	2022	A Plasma Circular RNA Profile Differentiates Subjects with Alzheimer's Disease and Mild Cognitive Impairment from Healthy Controls.		hsa_circRNA_050263	hsa_circ_ATP13A1	ATP13A1	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_050263 is up-regulated in plasma from AD patients and similarly increased in MCI vs healthy controls, suggesting potential diagnostic utility. The study infers a circRNA-miRNA-mRNA regulatory role via bioinformatic prediction and enrichment analyses related to AD-associated biological processes."	0.5963
36362022	International journal of molecular sciences	2022	A Plasma Circular RNA Profile Differentiates Subjects with Alzheimer's Disease and Mild Cognitive Impairment from Healthy Controls.		hsa_circRNA_403959	hsa_circ_BRAF	BRAF	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_403959 (BRAF locus) is increased in plasma from AD patients and also increased in MCI; it is particularly higher in MCI than in AD/HC. The study proposes it as a potential non-invasive biomarker, with only limited predicted miRNA interactions reported."	0.5963
36362022	International journal of molecular sciences	2022	A Plasma Circular RNA Profile Differentiates Subjects with Alzheimer's Disease and Mild Cognitive Impairment from Healthy Controls.		hsa_circRNA_003022 / circRNA_03022	hsa_circ_PITRM1	PITRM1	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_003022 (PITRM1 locus) is increased in plasma from AD patients and also elevated in MCI vs controls. The work models it within a predicted circRNA-miRNA-mRNA network, with multiple shared miRNAs, and links its putative targets to AD-relevant processes via enrichment analyses."	0.5963
36362022	International journal of molecular sciences	2022	A Plasma Circular RNA Profile Differentiates Subjects with Alzheimer's Disease and Mild Cognitive Impairment from Healthy Controls.		hsa_circRNA_102049 / circRNA_102049	hsa_circ_TADA2A	TADA2A	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR; Microarray	hsa_circRNA_102049 (TADA2A locus) is decreased in plasma of AD patients compared with healthy controls and does not show AD-like upregulation in MCI. The study supports its diagnostic potential via ROC analysis and suggests a predicted circRNA-miRNA-mRNA regulatory role based on bioinformatic analyses.	0.5963
36362022	International journal of molecular sciences	2022	A Plasma Circular RNA Profile Differentiates Subjects with Alzheimer's Disease and Mild Cognitive Impairment from Healthy Controls.		hsa_circRNA_102619 / circRNA_102619	hsa_circ_NOL10	NOL10	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR; Microarray	hsa_circRNA_102619 (NOL10 locus) is reduced in plasma of AD patients vs controls and is supported as a diagnostic biomarker by ROC analysis. Bioinformatic network/enrichment analyses link its predicted miRNA-mediated targets to AD-associated genes (including ADAM10 and MAPT) and AD-relevant pathways.	0.5963
36366842	Combinatorial chemistry & high throughput screening	2023	Gastric Cancer Growth Modulated by circSNTB2/miR-6938-5p/G0S2 and PDCD4.	hsa_circ_0040039	circSNTB2	hsa_circ_SNTB2	SNTB2	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"circSNTB2 (hsa_circ_0040039) is significantly down-regulated in gastric cancer tissues. It is proposed to act as a ceRNA that sponges miR-6938-5p, thereby affecting downstream target genes G0S2 and PDCD4 and influencing GC tumorigenesis, with potential biomarker value for GC diagnosis/therapy."	0.2465
36369467	Experimental & molecular medicine	2022	Hypoxia-induced circRNF13 promotes the progression and glycolysis of pancreatic cancer.	hsa_circ_0001346	circRNF13 / circ-0001346	hsa_circ_RNF13	RNF13	pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; ISH; RNA-seq	"In pancreatic cancer, circRNF13 (hsa_circ_0001346) is up-regulated (including under hypoxia), promotes proliferation, angiogenesis, invasion/metastasis and glycolysis, and is associated with poor overall survival. Mechanistically, its biogenesis is promoted by HIF-1alpha and EIF4A3, and it acts as a cytoplasmic ceRNA that sponges miR-654-3p to upregulate PDK3."	0.8941
36371782	Journal of clinical laboratory analysis	2022	Knockdown of hsa_circ_0043691 restrains the progression of gastric cancer by decoying miR-1294 to target pre-leukemia transcription factor 3.	hsa_circ_0043691	cicrNT5C3L 	hsa_circ_NT5C3L	NT5C3L	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"hsa_circ_0043691 is up-regulated in gastric cancer tissues and cell lines and is mainly localized in the cytoplasm. It promotes malignant phenotypes (proliferation, migration/invasion, angiogenesis), enhances glutaminolysis, and supports tumor growth by sponging miR-1294 to upregulate PBX3."	0.8689
36386298	Frontiers in cardiovascular medicine	2022	"mRNA, lncRNA, and circRNA expression profiles in a new aortic dissection murine model induced by hypoxia and Ang II."	mmu_circ_0008002				aortic dissection / AD	MONDO:0022470	aortic dissection lentiginosis	up-regulated	Microarray	mmu_circ_0008002 was identified by mouse ceRNA microarray as an upregulated differentially expressed circRNA in CIH + Ang II-induced OSA-AD aortic tissues. The study did not validate or characterize its specific function or mechanism.	0.31
36386298	Frontiers in cardiovascular medicine	2022	"mRNA, lncRNA, and circRNA expression profiles in a new aortic dissection murine model induced by hypoxia and Ang II."	mmu_circ_0008306				aortic dissection / AD	MONDO:0022470	aortic dissection lentiginosis	up-regulated	Microarray	"mmu_circ_0008306 was reported as an upregulated differentially expressed circRNA in mouse OSA-AD aortic tissue based on ceRNA microarray screening, without further functional/mechanistic validation."	0.31
36386298	Frontiers in cardiovascular medicine	2022	"mRNA, lncRNA, and circRNA expression profiles in a new aortic dissection murine model induced by hypoxia and Ang II."	mmu_circ_0002842				aortic dissection / AD	MONDO:0022470	aortic dissection lentiginosis	up-regulated	Microarray	"mmu_circ_0002842 was identified as upregulated in mouse OSA-AD aortic tissue by ceRNA microarray; no downstream targets, pathways, or functional assays were reported for this circRNA."	0.31
36386298	Frontiers in cardiovascular medicine	2022	"mRNA, lncRNA, and circRNA expression profiles in a new aortic dissection murine model induced by hypoxia and Ang II."	mmu_circ_0000648				aortic dissection / AD	MONDO:0022470	aortic dissection lentiginosis	up-regulated	Microarray	"mmu_circ_0000648 is an upregulated DEcircRNA in the mouse OSA-AD model identified by ceRNA microarray, with no specific mechanistic or functional data provided."	0.31
36386298	Frontiers in cardiovascular medicine	2022	"mRNA, lncRNA, and circRNA expression profiles in a new aortic dissection murine model induced by hypoxia and Ang II."	mmu_circ_0000746				aortic dissection / AD	MONDO:0022470	aortic dissection lentiginosis	up-regulated	Microarray	"mmu_circ_0000746 was screened as an upregulated circRNA in mouse OSA-AD aortic tissue using a ceRNA microarray, without additional validation or mechanistic studies for this circRNA."	0.31
36386298	Frontiers in cardiovascular medicine	2022	"mRNA, lncRNA, and circRNA expression profiles in a new aortic dissection murine model induced by hypoxia and Ang II."	mmu_circ_0013434				aortic dissection / AD	MONDO:0022470	aortic dissection lentiginosis	up-regulated	Microarray	"mmu_circ_0013434 was identified as upregulated in OSA-AD mouse aorta by microarray screening; the paper did not report specific targets, localization, or functions for this circRNA."	0.31
36386298	Frontiers in cardiovascular medicine	2022	"mRNA, lncRNA, and circRNA expression profiles in a new aortic dissection murine model induced by hypoxia and Ang II."	mmu_circ_0007410				aortic dissection / AD	MONDO:0022470	aortic dissection lentiginosis	up-regulated	Microarray	mmu_circ_0007410 was found upregulated in mouse OSA-AD aortic tissue by microarray; the study did not investigate its specific role or ceRNA interactions.	0.31
36386298	Frontiers in cardiovascular medicine	2022	"mRNA, lncRNA, and circRNA expression profiles in a new aortic dissection murine model induced by hypoxia and Ang II."	mmu_circ_0005483				aortic dissection / AD	MONDO:0022470	aortic dissection lentiginosis	up-regulated	Microarray	"mmu_circ_0005483 was screened as an upregulated circRNA in mouse OSA-AD aortic tissue via microarray analysis, with no reported downstream interactions or functional assays."	0.31
36386298	Frontiers in cardiovascular medicine	2022	"mRNA, lncRNA, and circRNA expression profiles in a new aortic dissection murine model induced by hypoxia and Ang II."	mmu_circ_0001921				aortic dissection / AD	MONDO:0022470	aortic dissection lentiginosis	up-regulated	Microarray	"mmu_circ_0001921 was identified as an upregulated DEcircRNA in mouse OSA-AD aortic tissue by microarray screening, with no additional characterization in this paper."	0.31
36386298	Frontiers in cardiovascular medicine	2022	"mRNA, lncRNA, and circRNA expression profiles in a new aortic dissection murine model induced by hypoxia and Ang II."	mmu_circ_0003720				aortic dissection / AD	MONDO:0022470	aortic dissection lentiginosis	up-regulated	Microarray	"mmu_circ_0003720 was identified as upregulated in mouse OSA-AD aortic tissue by ceRNA microarray, but was not functionally validated or mechanistically analyzed in this study."	0.31
36386298	Frontiers in cardiovascular medicine	2022	"mRNA, lncRNA, and circRNA expression profiles in a new aortic dissection murine model induced by hypoxia and Ang II."	mmu_circ_0004366		mmu_circ_Mtap1b	Mtap1b	aortic dissection / AD	MONDO:0022470	aortic dissection lentiginosis	down-regulated	Microarray	"mmu_circ_0004366, derived from host gene Mtap1b, was identified as a downregulated circRNA in mouse OSA-AD aortic tissue by ceRNA microarray; no direct functional assays or miRNA/mRNA interactions were reported for this circRNA."	0.31
36386298	Frontiers in cardiovascular medicine	2022	"mRNA, lncRNA, and circRNA expression profiles in a new aortic dissection murine model induced by hypoxia and Ang II."	mmu_circ_0000570				aortic dissection / AD	MONDO:0022470	aortic dissection lentiginosis	down-regulated	Microarray	"mmu_circ_0000570 was identified as downregulated in mouse OSA-AD aortic tissues by ceRNA microarray analysis, without subsequent functional or mechanistic validation."	0.31
36386298	Frontiers in cardiovascular medicine	2022	"mRNA, lncRNA, and circRNA expression profiles in a new aortic dissection murine model induced by hypoxia and Ang II."	mmu_circ_0001881				aortic dissection / AD	MONDO:0022470	aortic dissection lentiginosis	down-regulated	Microarray	"mmu_circ_0001881 was identified as downregulated in mouse OSA-AD aortic tissue by ceRNA microarray, with no further experimental validation or mechanistic exploration reported."	0.31
36386298	Frontiers in cardiovascular medicine	2022	"mRNA, lncRNA, and circRNA expression profiles in a new aortic dissection murine model induced by hypoxia and Ang II."	mmu_circ_0016354				aortic dissection / AD	MONDO:0022470	aortic dissection lentiginosis	down-regulated	Microarray	"mmu_circ_0016354 was identified as downregulated in mouse OSA-AD aorta by microarray screening, with no further functional characterization in the paper."	0.31
36386298	Frontiers in cardiovascular medicine	2022	"mRNA, lncRNA, and circRNA expression profiles in a new aortic dissection murine model induced by hypoxia and Ang II."	mmu_circ_0014597				aortic dissection / AD	MONDO:0022470	aortic dissection lentiginosis	down-regulated	Microarray	"mmu_circ_0014597 was reported as a downregulated circRNA in mouse OSA-AD aortic tissue based on microarray screening, without further mechanistic validation."	0.31
36386298	Frontiers in cardiovascular medicine	2022	"mRNA, lncRNA, and circRNA expression profiles in a new aortic dissection murine model induced by hypoxia and Ang II."	mmu_circ_0004377		mmu_circ_Mtap1b	Mtap1b	aortic dissection / AD	MONDO:0022470	aortic dissection lentiginosis	down-regulated	Microarray	"mmu_circ_0004377, originating from Mtap1b, was found downregulated in the mouse OSA-AD model aorta by microarray; the study linked it only to host-gene based network analysis without circRNA-specific functional experiments."	0.31
36386298	Frontiers in cardiovascular medicine	2022	"mRNA, lncRNA, and circRNA expression profiles in a new aortic dissection murine model induced by hypoxia and Ang II."	mmu_circ_0004358		mmu_circ_Mtap1b	Mtap1b	aortic dissection / AD	MONDO:0022470	aortic dissection lentiginosis	down-regulated	Microarray	mmu_circ_0004358 is a Mtap1b-derived circRNA reported as downregulated in mouse OSA-AD aortic tissue from microarray data; the study did not provide circRNA-specific functional assays or interaction validation.	0.31
36386298	Frontiers in cardiovascular medicine	2022	"mRNA, lncRNA, and circRNA expression profiles in a new aortic dissection murine model induced by hypoxia and Ang II."	mmu_circ_0009280				aortic dissection / AD	MONDO:0022470	aortic dissection lentiginosis	down-regulated	Microarray	"mmu_circ_0009280 was identified as downregulated in mouse OSA-AD aortic tissue by microarray screening, with no additional circRNA-specific functional evidence provided."	0.31
36386298	Frontiers in cardiovascular medicine	2022	"mRNA, lncRNA, and circRNA expression profiles in a new aortic dissection murine model induced by hypoxia and Ang II."	mmu_circ_0015838				aortic dissection / AD	MONDO:0022470	aortic dissection lentiginosis	down-regulated	Microarray	"mmu_circ_0015838 was identified as downregulated in mouse OSA-AD aortic tissue by microarray profiling; no specific mechanisms, targets, or functional assays were provided for this circRNA."	0.31
36386298	Frontiers in cardiovascular medicine	2022	"mRNA, lncRNA, and circRNA expression profiles in a new aortic dissection murine model induced by hypoxia and Ang II."	mmu_circ_0007117				aortic dissection / AD	MONDO:0022470	aortic dissection lentiginosis	down-regulated	Microarray	"mmu_circ_0007117 was identified as downregulated in mouse OSA-AD aortic tissue from ceRNA microarray results, without further circRNA-specific validation or mechanistic studies."	0.31
36387162	Frontiers in oncology	2022	Circ_0084043-miR-134-5p axis regulates PCDH9 to suppress melanoma.	hsa_circ_0084043	circ_0084043 / circ 0084043			melanoma	MONDO:0005105	melanoma	up-regulated	RT-qPCR	"circ_0084043 is up-regulated in melanoma cells and promotes malignant behavior. Mechanistically, it sponges miR-134-5p to indirectly regulate PCDH9 and related tumor-associated proteins, thereby enhancing migration and suppressing apoptosis; inhibition of circ_0084043 also reduces PD-L1 levels."	0.593
36389171	Frontiers in cellular and infection microbiology	2022	CircRNA and miRNA expression analysis in livers of mice with Toxoplasma gondii infection.		6:124519352|124575359			toxoplasmosis	MONDO:0005989	toxoplasmosis	dysregulated	RT-qPCR; RNA-seq	"This circRNA is differentially expressed in mouse livers after T. gondii infection and is placed in a circRNA_miRNA co-expression network. It is associated with (and described as regulating) miRNAs such as mmu-miR-146a-5p and mmu-miR-150-5p, suggesting a potential role in hepatic immune/inflammatory responses during toxoplasmosis."	0.4997
36389171	Frontiers in cellular and infection microbiology	2022	CircRNA and miRNA expression analysis in livers of mice with Toxoplasma gondii infection.		4:61958498|62052011			toxoplasmosis	MONDO:0005989	toxoplasmosis	dysregulated	RT-qPCR; RNA-seq	"This circRNA is differentially expressed in mouse livers during T. gondii infection and appears in the circRNA_miRNA co-expression network. It is associated with mmu-miR-146a-5p, implying a potential involvement in immune/inflammatory regulation during hepatic toxoplasmosis, but downstream effectors were not validated."	0.4997
36389171	Frontiers in cellular and infection microbiology	2022	CircRNA and miRNA expression analysis in livers of mice with Toxoplasma gondii infection.		12:103731961|103897311			toxoplasmosis	MONDO:0005989	toxoplasmosis	dysregulated	RT-qPCR; RNA-seq	This differentially expressed circRNA is part of a network predicted to regulate mmu-miR-1247-3p during T. gondii infection in mouse liver. The authors interpret this set of circRNAs as being involved in liver inflammation associated with infection.	0.4997
36389171	Frontiers in cellular and infection microbiology	2022	CircRNA and miRNA expression analysis in livers of mice with Toxoplasma gondii infection.		12:103854668|103947209			toxoplasmosis	MONDO:0005989	toxoplasmosis	dysregulated	RT-qPCR; RNA-seq	This differentially expressed circRNA is included among circRNAs predicted to regulate mmu-miR-1247-3p in infected mouse livers. The paper interprets this network module as participating in liver inflammation during T. gondii infection.	0.4997
36389171	Frontiers in cellular and infection microbiology	2022	CircRNA and miRNA expression analysis in livers of mice with Toxoplasma gondii infection.		5:145708877|145868684			toxoplasmosis	MONDO:0005989	toxoplasmosis	dysregulated	RT-qPCR; RNA-seq	This DE circRNA is one of several circRNAs linked to mmu-miR-1247-3p in the constructed network for infected mouse livers. The authors suggest such circRNAs participate in liver inflammation during toxoplasmosis.	0.4997
36389171	Frontiers in cellular and infection microbiology	2022	CircRNA and miRNA expression analysis in livers of mice with Toxoplasma gondii infection.		7:13832577|13909898			toxoplasmosis	MONDO:0005989	toxoplasmosis	dysregulated	RT-qPCR; RNA-seq	This DE circRNA is one of the circRNAs linked to mmu-miR-1247-3p in the infection-associated network. The authors interpret these circRNAs as participating in liver inflammation in mice after T. gondii infection.	0.4997
36397164	Cancer cell international	2022	Circular RNA circPTPRF promotes the progression of GBM via sponging miR-1208 to up-regulate YY1.	hsa_circ_0012077	circPTPRF	hsa_circ_PTPRF	PTPRF	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; RNA-seq	"circPTPRF is up-regulated in glioma/GBM and correlates with higher WHO grade and poorer survival. Functionally, it promotes GBM cell proliferation, invasion, and neurosphere formation and enhances intracranial tumor growth in vivo by acting as a ceRNA that sponges miR-1208 to upregulate YY1."	0.8511
36397308	Balkan medical journal	2023	Hypoxia-induced Circular RNA hsa_circ_0006508 Promotes the Warburg Effect in Colorectal Cancer Cells.	hsa_circ_0006508	circ_0006508 / circ_6508	hsa_circ_VMP1	VMP1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"In CRC, circ_0006508 is up-regulated and induced by hypoxia via HIF-1alpha-driven transcription. It mainly localizes to the cytoplasm and promotes proliferation/colony formation and the Warburg effect by sponging miR-1272. High circ_0006508 expression correlates with advanced TNM stage and poorer overall survival."	0.725
36399471	PloS one	2022	Bioinformatic analysis and clinical diagnostic value of hsa_circ_0004099 in acute ischemic stroke.	hsa_circ_0004099		hsa_circ_DENND5A	DENND5A	ischemic stroke / IS	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR; Microarray	hsa_circ_0004099 is down-regulated in AIS patient plasma and its lower level is associated with higher NIHSS severity and longer infarct time. It shows strong diagnostic potential for AIS (ROC AUC 0.923). Bioinformatic analyses predict a ceRNA network with 10 candidate miRNAs and downstream targets enriched in apoptosis/transcriptional regulation and cancer-related/proliferation-associated genes.	0.5534
36402769	Nature communications	2022	Mutant RIG-I enhances cancer-related inflammation through activation of circRIG-I signaling.		circRIG-I	hsa_circ_DDX58	DDX58	colon cancer	MONDO:0021063	malignant colon neoplasm	up-regulated	RT-qPCR; Northern Blot; RNA-seq	"circRIG-I (mmu-DDX58_0004 / human circRIG-I) is induced by mutant Rig-i/RIG-I and is upregulated in colon cancer. It binds DDX3X and enhances MAVS/TRAF5/TBK1 signaling to activate IRF3-driven type I IFN transcription, promoting inflammatory damage and cancer-related inflammation; higher circRIG-I predicts poorer outcome."	0.8545
36402769	Nature communications	2022	Mutant RIG-I enhances cancer-related inflammation through activation of circRIG-I signaling.		mmu-DDX58_0004 / circ_RIG-I	mmu_circ_Ddx58	Ddx58	colon cancer	MONDO:0021063	malignant colon neoplasm	up-regulated	RT-qPCR; Northern Blot; RNA-seq	"circRIG-I (mmu-DDX58_0004 / human circRIG-I) is induced by mutant Rig-i/RIG-I and is upregulated in colon cancer. It binds DDX3X and enhances MAVS/TRAF5/TBK1 signaling to activate IRF3-driven type I IFN transcription, promoting inflammatory damage and cancer-related inflammation; higher circRIG-I predicts poorer outcome."	0.8545
36402996	Journal of nanobiotechnology	2022	Uterine macrophages as treatment targets for therapy of premature rupture of membranes by modified ADSC-EVs through a circRNA/miRNA/NF-kappaB pathway.	mmu_circ_0002047	circRNA_0002047 / mmu_circRNA_0002047	mmu_circ_B4galnt1	B4galnt1	premature rupture of membranes / PROM	MONDO:0012511	preterm premature rupture of the membranes	up-regulated	RT-qPCR; Microarray	"In the LPS-induced PROM mouse model, cir2047 (from host gene B4galnt1) is up-regulated in uterine macrophages. It functions as a miRNA sponge for miR-1931, relieving repression of Traf6 and sustaining NF-kappaB activation, thereby maintaining M1 polarization and enhancing MMP secretion to accelerate PROM; si-cir2047 delivered by modified ADSC-EVs attenuates these effects in vivo."	0.734
36405685	Frontiers in immunology	2022	Hsa_Circ_0066351 Acts as a Prognostic and Immunotherapeutic Biomarker in Colorectal Cancer.	hsa_circ_0066351	human circ_0066351 / circ_0066351	hsa_circ_FLNB	FLNB	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	This study identified hsa_circ_0066351 (from FLNB) as significantly down-regulated in colorectal cancer tissues and cell lines. Functional assays showed it suppresses CRC cell proliferation. Bioinformatic ceRNA analysis proposed a hsa_circ_0066351_miR-27a-3p/miR-379-5p_mRNA network with prognostic and potential immunotherapy-related relevance.	0.7713
36409215	Investigative ophthalmology & visual science	2022	Differential Circular RNA Expression Profiling of Orbital Connective Tissue From Patients With Type I and Type II Thyroid-Associated Ophthalmopathy.	hsa_circ_0004447		hsa_circ_PRKCE	PRKCE	thyroid-associated ophthalmopathy / TAO	MONDO:0001509	endocrine exophthalmos	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0004447 is down-regulated in type II TAO compared with type I TAO and is one of the validated dysregulated circRNAs that may contribute to TAO subtype-related orbital fibroblast differentiation.	0.4032
36409215	Investigative ophthalmology & visual science	2022	Differential Circular RNA Expression Profiling of Orbital Connective Tissue From Patients With Type I and Type II Thyroid-Associated Ophthalmopathy.	hsa_circ_0004222		hsa_circ_VPS13D	VPS13D	thyroid-associated ophthalmopathy / TAO	MONDO:0001509	endocrine exophthalmos	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0004222 is up-regulated in type II TAO compared with type I TAO and is a validated differential circRNA; the paper discusses its host gene VPS13D in relation to mitophagy, suggesting possible relevance to TAO subtype biology."	0.4032
36409215	Investigative ophthalmology & visual science	2022	Differential Circular RNA Expression Profiling of Orbital Connective Tissue From Patients With Type I and Type II Thyroid-Associated Ophthalmopathy.	hsa_circ_0007006		hsa_circ_DYM	DYM	thyroid-associated ophthalmopathy / TAO	MONDO:0001509	endocrine exophthalmos	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0007006 is down-regulated in type II TAO versus type I TAO. In orbital fibroblasts, its lentiviral overexpression decreases COL1A1 and MMP2 protein levels, and the study links this axis to relaxin signaling and fibrosis-related TAO subtyping."	0.5623
36409215	Investigative ophthalmology & visual science	2022	Differential Circular RNA Expression Profiling of Orbital Connective Tissue From Patients With Type I and Type II Thyroid-Associated Ophthalmopathy.	hsa_circ_0097201		hsa_circ_ACACB	ACACB	thyroid-associated ophthalmopathy / TAO	MONDO:0001509	endocrine exophthalmos	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0097201 is down-regulated in type II TAO compared with type I TAO and was validated by RT-qPCR as one of the subtype-associated dysregulated circRNAs.	0.4032
36409215	Investigative ophthalmology & visual science	2022	Differential Circular RNA Expression Profiling of Orbital Connective Tissue From Patients With Type I and Type II Thyroid-Associated Ophthalmopathy.	hsa_circ_0008775		hsa_circ_VEZT	VEZT	thyroid-associated ophthalmopathy / TAO	MONDO:0001509	endocrine exophthalmos	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0008775 is down-regulated in type II TAO compared with type I TAO and was validated by RT-qPCR; the paper notes VEZT as its host gene, implying potential involvement in subtype-related biology."	0.4032
36409215	Investigative ophthalmology & visual science	2022	Differential Circular RNA Expression Profiling of Orbital Connective Tissue From Patients With Type I and Type II Thyroid-Associated Ophthalmopathy.	hsa_circ_0104799		hsa_circ_AKAP13	AKAP13	thyroid-associated ophthalmopathy / TAO	MONDO:0001509	endocrine exophthalmos	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0104799 is down-regulated in type II TAO compared with type I TAO and was validated by RT-qPCR as a subtype-associated dysregulated circRNA.	0.4032
36409215	Investigative ophthalmology & visual science	2022	Differential Circular RNA Expression Profiling of Orbital Connective Tissue From Patients With Type I and Type II Thyroid-Associated Ophthalmopathy.	hsa_circ_0128243		hsa_circ_RBM27	RBM27	thyroid-associated ophthalmopathy / TAO	MONDO:0001509	endocrine exophthalmos	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0128243 is down-regulated in type II TAO compared with type I TAO and was validated by RT-qPCR as a subtype-associated dysregulated circRNA.	0.4032
36411517	Cancer science	2023	has_circ_0070512 promotes prostate cancer progression by regulating the miR-338-3p/hedgehog signaling pathway.	hsa_circ_0070512		hsa_circ_PPP3CA	PPP3CA	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; ISH	"hsa_circ_0070512 is up-regulated in prostate cancer tissues and cell lines, mainly localized in the cytoplasm, and promotes PCa proliferation and migration. It functions as a ceRNA by sponging miR-338-3p, increasing GLI2 expression and activating hedgehog signaling, and it enhances tumor growth in a PC3 xenograft model."	0.8192
36424704	Journal of gynecologic oncology	2023	Circ_0075960 targets the miR-202-5p/CTNND1 axis to promote the growth and migration of endometrial carcinoma cells via regulating Wnt/beta-catenin signaling activity.	hsa_circ_0075960	circ_0075960			Endometrial carcinoma	MONDO:0002447	endometrial carcinoma	up-regulated	RT-qPCR	"circ_0075960 is up-regulated in endometrial carcinoma tissues and cell lines and promotes malignant phenotypes (proliferation, migration, tumor growth) while inhibiting apoptosis. Mechanistically, it acts as a ceRNA for miR-202-5p to increase CTNND1 expression and activate Wnt/beta-catenin signaling."	0.7662
36425075	Frontiers in genetics	2022	Hsa_circ_0074158 regulates the endothelial barrier function in sepsis and its potential value as a biomarker.	hsa_circ_0074158		hsa_circ_CTNNA1	CTNNA1	sepsis	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0074158 is up-regulated in LPS-induced sepsis models and in sepsis patient whole blood. Functionally, its knockdown restores VE-cadherin and reduces endothelial permeability, suggesting it contributes to endothelial barrier disruption, potentially via a predicted hsa-miR-515-5p/CDH5 ceRNA axis. Clinically, high expression is associated with poorer overall survival in sepsis patients."	0.7548
36428672	Cancers	2022	N6-Methyladenosine Modification of CIRCKRT17 Initiated by METTL3 Promotes Osimertinib Resistance of Lung Adenocarcinoma by EIF4A3 to Enhance YAP1 Stability.	hsa_circ_0043632	CircKRT17 / Circular RNA KRT17	hsa_circ_KRT17	KRT17	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circKRT17 is up-regulated in osimertinib-insensitive LUAD tissues and resistant cell lines and promotes osimertinib resistance. Mechanistically, METTL3-mediated m6A modification stabilizes circKRT17, which recruits EIF4A3 to increase YAP1 mRNA stability and enhance YAP1 nuclear localization/activation, supporting tumor growth and survival under osimertinib."	0.8519
36428974	Cells	2022	CircANKRD12 Is Induced in Endothelial Cell Response to Oxidative Stress.	hsa_circ_0000826	circular Ankyrin Repeat Domain 12 / circANKRD12	hsa_circ_ANKRD12	ANKRD12	critical limb ischemia / CLI	MONDO:0005385	vascular disorder	up-regulated	RT-qPCR	"In CLI patient skeletal muscle, circANKRD12 itself was not significantly changed, but the ANKRD12 circular-to-linear ratio was increased. Functionally, circANKRD12 supports endothelial tubulogenesis and proliferation under oxidative stress, and network analysis links it to p53 and Foxo-related stress-response programs."	0.6722
36429000	Cells	2022	Circular RNA hsa_circ_0051040 Promotes Hepatocellular Carcinoma Progression by Sponging miR-569 and Regulating ITGAV Expression.	hsa_circ_0051040	circ_0051040 / circ0051040	hsa_circ_FBL	FBL	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"hsa_circ_0051040 is up-regulated in HCC tissues/cell lines and promotes proliferation, migration, invasion, and metastasis. It predominantly localizes to the cytoplasm and functions as a ceRNA by sponging miR-569 to upregulate ITGAV, thereby promoting EMT. High expression is associated with poorer survival and its plasma level shows diagnostic potential for HCC."	0.8846
36430152	International journal of molecular sciences	2022	"circSMARCA5 Is an Upstream Regulator of the Expression of miR-126-3p, miR-515-5p, and Their mRNA Targets, Insulin-like Growth Factor Binding Protein 2 (IGFBP2) and NRAS Proto-Oncogene, GTPase (NRAS) in Glioblastoma."		circSMARCA5	hsa_circ_SMARCA5	SMARCA5	glioblastoma / GBM	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR	"In glioblastoma, circSMARCA5 is down-regulated and functions as a tumor suppressor. It acts as an upstream regulator increasing miR-126-3p and miR-515-5p, which are associated with reduced expression of their oncogenic mRNA targets IGFBP2 and NRAS, and is also linked to RBP (SRSF1) decoy/splicing-related regulation."	0.4535
36433954	Nature communications	2022	circCsnk1g3- and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment.		circCsnk1g3	mmu_circ_Csnk1g3	Csnk1g3	soft-tissue sarcomas / STS	MONDO:0005089	sarcoma	up-regulated	RT-qPCR; RNA-seq	"In murine UPS sarcoma cells, circCsnk1g3 is up-regulated and promotes tumorigenesis in vivo. It localizes to the cytoplasm and physically associates with RIG-I, buffering RIG-I_mediated interferon/pro-inflammatory programs, thereby shaping an immune-excluded, pro-tumor microenvironment."	0.7347
36433954	Nature communications	2022	circCsnk1g3- and circAnkib1-regulated interferon responses in sarcoma promote tumorigenesis by shaping the immune microenvironment.		circAnkib1	mmu_circ_Ankib1	Ankib1	soft-tissue sarcomas / STS	MONDO:0005089	sarcoma	up-regulated	RT-qPCR; RNA-seq	"In murine UPS sarcoma, circAnkib1 is up-regulated and promotes tumor growth in immune-competent mice. It localizes to the cytoplasm and interacts with RIG-I, dampening RIG-I_dependent interferon/pro-inflammatory gene expression in tumor cells to shape the immune microenvironment."	0.7265
36434559	BMC cancer	2022	Diagnostic value of circN4BP2L2 in type I and type II epithelial ovarian cancer.		circN4BP2L2	hsa_circ_N4BP2L2	N4BP2L2	epithelial ovarian cancer / EOC	MONDO:0005140	ovarian carcinoma	down-regulated	RT-qPCR	"Plasma circN4BP2L2 is significantly down-regulated in both type I and type II epithelial ovarian cancer compared with benign ovarian cyst and healthy controls, and shows diagnostic value with ROC/AUC analyses. Lower circN4BP2L2 levels correlate with adverse clinicopathologic features (advanced stage in type I; lymph node metastasis in type II). The molecular mechanism was not determined, but prior in vitro work cited by the authors suggests decreased circN4BP2L2 may enhance invasion and metastasis-related behaviors in EOC cells."	0.4187
36434577	BMC pulmonary medicine	2022	CircRNA has_circ_0017109 promotes lung tumor progression via activation of Wnt/beta-catenin signaling due to modulating miR-671-5p/FZD4 axis.	hsa_circ_0017109	circ_0017109 / Circ-0017109			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0017109 is up-regulated in NSCLC tissues and cell lines and correlates with worse overall survival. Functionally, it promotes NSCLC proliferation and tumorigenesis and inhibits apoptosis by sponging miR-671-5p, thereby increasing FZD4 and activating Wnt/beta-catenin signaling."	0.8396
36434693	BMC urology	2022	CircRNA/miRNA/mRNA axis participates in the progression of partial bladder outlet obstruction.		chr3:113195876|113197193			bladder outlet obstruction / BOO	MONDO:0006679	bladder neck obstruction	down-regulated	RT-qPCR	"chr3:113195876|113197193 is down-regulated in pBOO rat bladder tissue and is proposed to act in a ceRNA axis by binding rno-miR-30c-1-3p, thereby affecting Gata4 expression. The axis is suggested to contribute to pBOO pathogenesis and may have biomarker potential."	0.31
36434693	BMC urology	2022	CircRNA/miRNA/mRNA axis participates in the progression of partial bladder outlet obstruction.		chr1:126188351|126195625			bladder outlet obstruction / BOO	MONDO:0006679	bladder neck obstruction	up-regulated	RT-qPCR	"chr1:126188351|126195625 is up-regulated in pBOO rat bladder tissue. It is proposed to participate in pBOO via a ceRNA axis involving rno-miR-153-5p and the mRNA Diaph3, and is suggested as a potential biomarker component."	0.31
36434693	BMC urology	2022	CircRNA/miRNA/mRNA axis participates in the progression of partial bladder outlet obstruction.		chr9:81258380|81275269			bladder outlet obstruction / BOO	MONDO:0006679	bladder neck obstruction	down-regulated	RT-qPCR	chr9:81258380|81275269 is down-regulated in pBOO rat bladder tissue and is included in a proposed ceRNA axis with rno-miR-135b-5p and Pigr. The study provides expression and in silico binding-site support but notes that further validation is needed.	0.31
36434735	Parasites & vectors	2022	Whole transcriptome analysis of HCT-8 cells infected by Cryptosporidium parvum.	hsa_circ_0019973				cryptosporidiosis	MONDO:0015474	cryptosporidiosis	up-regulated	RT-qPCR; RNA-seq	"This study identified a single differentially expressed circRNA (hsa_circ_0019973) that is up-regulated in C. parvum-infected HCT-8 cells (12 hpi) and validated by qRT-PCR. It was predicted to act as a ceRNA by sponging miRNAs (including hsa-miR-324-3p, hsa-miR-3127-5p, hsa-miR-6852-3p) and was linked to an hsa_circ_0019973_hsa-miR-324-3p_RPS6KA6 relationship related to MAPK signaling, with enrichment signals involving apoptosis-related pathways."	0.2465
36435781	Journal of translational medicine	2022	Circular RNA circLOC101928570 suppresses systemic lupus erythematosus progression by targeting the miR-150-5p/c-myb axis.		circLOC101928570			systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	down-regulated	RT-qPCR; RNA-seq	"circLOC101928570 is down-regulated in PBMCs from SLE patients and correlates with disease activity. It mainly localizes to the cytoplasm and functions as a ceRNA that sponges miR-150-5p to de-repress c-myb, thereby increasing IL2RA transcription and modulating immune-inflammatory responses while inhibiting apoptosis."	0.8523
36438474	Theranostics	2022	circHIPK3 prevents cardiac senescence by acting as a scaffold to recruit ubiquitin ligase to degrade HuR.	hsa_circ_0000284	circHIPK3	hsa_circ_HIPK3	HIPK3	cardiac senescence	MONDO:0005267	heart disorder	down-regulated	RT-qPCR; RNA-seq	"In aging hearts, circHIPK3 is down-regulated. Functionally, circHIPK3 suppresses cardiomyocyte senescence and supports cardiac function by scaffolding HuR with the E3 ligase beta-TrCP in the cytoplasm, promoting HuR ubiquitination/degradation and reducing p21 mRNA stabilization. UMSC-derived exosomes can deliver circHIPK3 to confer anti-senescence and cardioprotective effects."	0.7753
36438474	Theranostics	2022	circHIPK3 prevents cardiac senescence by acting as a scaffold to recruit ubiquitin ligase to degrade HuR.	mmu_circ_0001052	circHIPK3	mmu_circ_HIPK3	HIPK3	cardiac senescence	MONDO:0005267	heart disorder	down-regulated	RT-qPCR; RNA-seq	"In aging hearts, circHIPK3 is down-regulated. Functionally, circHIPK3 suppresses cardiomyocyte senescence and supports cardiac function by scaffolding HuR with the E3 ligase beta-TrCP in the cytoplasm, promoting HuR ubiquitination/degradation and reducing p21 mRNA stabilization. UMSC-derived exosomes can deliver circHIPK3 to confer anti-senescence and cardioprotective effects."	0.7753
36439541	Frontiers in surgery	2022	Screening and analysis of differentially expressed circRNAs and miRNAs in chronic diabetic extremity wounds.		circRNA-100451 / hsa_circRNA_100451	hsa_circ_RPS6KC1	RPS6KC1	chronic diabetic extremity wounds	MONDO:0004605	chronic ulcer of skin	down-regulated	RT-qPCR; RNA-seq	circRNA-100451 (hsa_circRNA_100451) is down-regulated in chronic diabetic wound tissue versus adjacent normal skin and was validated by RT-qPCR consistent with RNA-seq. It is included as part of a predicted circRNA-miRNA ceRNA network (interaction predicted with hsa-miR-200b-3p).	0.4032
36439541	Frontiers in surgery	2022	Screening and analysis of differentially expressed circRNAs and miRNAs in chronic diabetic extremity wounds.		circRNA-103107 / hsa_circRNA_103107	hsa_circ_TPTE	TPTE	chronic diabetic extremity wounds / diabetic chronic refractory wounds / diabetes refractory wounds	MONDO:0004605	chronic ulcer of skin	down-regulated	RT-qPCR; RNA-seq	circRNA-103107 (hsa_circRNA_103107) is down-regulated in chronic diabetic wound tissue versus adjacent normal skin and its differential expression was validated by RT-qPCR. It is part of a predicted ceRNA network and is linked to miR-203a-3p in the circRNA-miRNA network described for diabetic wound healing.	0.4032
36439541	Frontiers in surgery	2022	Screening and analysis of differentially expressed circRNAs and miRNAs in chronic diabetic extremity wounds.		hsa_circRNA_100141	hsa_circ_PTP4A2	PTP4A2	chronic diabetic extremity wounds / diabetic chronic refractory wounds / diabetes refractory wounds	MONDO:0004605	chronic ulcer of skin	up-regulated	RNA-seq	"hsa_circRNA_100141 is up-regulated in chronic diabetic wound tissue and is included in the predicted diabetic-wound ceRNA network. It is reported to have a network relationship with miR-203a-3p, suggesting a circRNA-miRNA regulatory interaction relevant to wound healing mechanisms."	0.348
36439541	Frontiers in surgery	2022	Screening and analysis of differentially expressed circRNAs and miRNAs in chronic diabetic extremity wounds.	hsa_circ_0001588	hsa_circRNA_001588 / circ_0001588	hsa_circ_HIST1H4E	HIST1H4E	chronic diabetic extremity wounds / diabetic chronic refractory wounds / diabetes refractory wounds	MONDO:0004605	chronic ulcer of skin	up-regulated	RNA-seq	"hsa_circRNA_001588 (hsa_circ_0001588) is up-regulated in chronic diabetic wound tissue and is included in the predicted diabetic-wound ceRNA network. It is linked to miR-514a-3p regulation in the network, suggesting a circRNA-miRNA interaction relevant to wound-healing dysregulation in diabetes."	0.348
36439541	Frontiers in surgery	2022	Screening and analysis of differentially expressed circRNAs and miRNAs in chronic diabetic extremity wounds.		hsa_circRNA_104330	hsa_circ_CCDC126	CCDC126	chronic diabetic extremity wounds / diabetic chronic refractory wounds / diabetes refractory wounds	MONDO:0004605	chronic ulcer of skin	up-regulated	RNA-seq	"hsa_circRNA_104330 is up-regulated in chronic diabetic wound tissue and is included in the predicted diabetic-wound ceRNA network. It is linked to miR-514a-3p regulation, suggesting a circRNA-miRNA interaction associated with impaired wound healing in diabetes."	0.348
36439541	Frontiers in surgery	2022	Screening and analysis of differentially expressed circRNAs and miRNAs in chronic diabetic extremity wounds.		hsa_circRNA_104175	hsa_circ_AMD1	AMD1	chronic diabetic extremity wounds / diabetic chronic refractory wounds / diabetes refractory wounds	MONDO:0004605	chronic ulcer of skin	down-regulated	RNA-seq	"hsa_circRNA_104175 is down-regulated in chronic diabetic wound tissue and is included in the predicted diabetic-wound ceRNA network. It is described as being related to miR-223-5p (and listed with hsa-miR-223-3p binding sites), supporting a circRNA-miRNA regulatory relationship in this disease context."	0.348
36439541	Frontiers in surgery	2022	Screening and analysis of differentially expressed circRNAs and miRNAs in chronic diabetic extremity wounds.		hsa_circRNA_102044	hsa_circ_ACACA	ACACA	chronic diabetic extremity wounds / diabetic chronic refractory wounds / diabetes refractory wounds	MONDO:0004605	chronic ulcer of skin	down-regulated	RNA-seq	"hsa_circRNA_102044 is down-regulated in chronic diabetic wound tissue and is included in the predicted diabetic-wound ceRNA network. It is described as having a network relationship with miR-205-5p, supporting a circRNA-miRNA regulatory interaction relevant to wound-healing dysregulation in diabetes."	0.348
36439901	Journal of oncology	2022	Circular RNA circ_0004488 Increases Cervical Cancer Paclitaxel Resistance via the miR-136/MEX3C Signaling Pathway.	hsa_circ_0004488	circ_0004488 / circ_000448	hsa_circ_PRPSAP2	PRPSAP2	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ_0004488 is up-regulated in cervical cancer (especially in CSC-enriched spheres and paclitaxel-resistant cells/tissues) and promotes proliferation, invasion, sphere formation, and paclitaxel resistance. Mechanistically, it mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-136 to upregulate MEX3C, enhancing CSC-like traits and chemoresistance."	0.8562
36440052	Frontiers in cardiovascular medicine	2022	Single-cell RNA-sequencing and microarray analyses to explore the pathological mechanisms of chronic thromboembolic pulmonary hypertension.	hsa_circ_0046159				chronic thromboembolic pulmonary hypertension / CTEPH	MONDO:0013024	chronic thromboembolic pulmonary hypertension	unknown	RT-qPCR; Microarray	The paper mentions hsa_circ_0046159 only as a previously reported circRNA upregulated in CTEPH; this study itself did not experimentally validate its expression change or mechanism.	0.1904
36440052	Frontiers in cardiovascular medicine	2022	Single-cell RNA-sequencing and microarray analyses to explore the pathological mechanisms of chronic thromboembolic pulmonary hypertension.	hsa_circ_0026692	circ_0026692			chronic thromboembolic pulmonary hypertension / CTEPH	MONDO:0013024	chronic thromboembolic pulmonary hypertension	unknown	Microarray	"circ_0026692 is proposed (via computational circRNA_miRNA_mRNA network analysis) to participate in CTEPH development by acting as a ceRNA for miR-20b-5p, thereby affecting APP in vascular remodeling-related cell types."	0.1768
36440052	Frontiers in cardiovascular medicine	2022	Single-cell RNA-sequencing and microarray analyses to explore the pathological mechanisms of chronic thromboembolic pulmonary hypertension.	hsa_circ_0021630	circ_0021630			chronic thromboembolic pulmonary hypertension / CTEPH	MONDO:0013024	chronic thromboembolic pulmonary hypertension	unknown	Microarray	circ_0021630 is highlighted as a key circRNA node in immune-cell circRNA_miRNA_mRNA networks and is also proposed to contribute to CTEPH via a ceRNA axis involving miR-20b-5p and APP in vascular remodeling-related cells.	0.1768
36440052	Frontiers in cardiovascular medicine	2022	Single-cell RNA-sequencing and microarray analyses to explore the pathological mechanisms of chronic thromboembolic pulmonary hypertension.	hsa_circ_0007400	circ_0007400			chronic thromboembolic pulmonary hypertension / CTEPH	MONDO:0013024	chronic thromboembolic pulmonary hypertension	unknown	Microarray	"circ_0007400 is proposed from network analysis to act as a ceRNA (circ_0007400_miR-6812-5p_TP53) in cancer stem cells and CRISPLD2+ cells, thereby promoting CTEPH progression through TP53 regulation."	0.1768
36440268	Frontiers in neuroscience	2022	Potential value of differentially expressed circular RNAs derived from circulating exosomes in the pathogenesis of rat spinal cord injury.			rno_circ_Setd5	Setd5	spinal cord injury / SCI	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR; RNA-seq	"This circulating exosome-derived circRNA is up-regulated in SCI rats and was incorporated into a predicted circRNA_miRNA_mRNA interaction network, suggesting a potential ceRNA regulatory role via several candidate miRNA targets."	0.5545
36440268	Frontiers in neuroscience	2022	Potential value of differentially expressed circular RNAs derived from circulating exosomes in the pathogenesis of rat spinal cord injury.			rno_circ_Fhit	Fhit	spinal cord injury / SCI	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR; RNA-seq	"This circulating exosome-derived circRNA (intronic, host gene Fhit) is up-regulated in SCI rats and was included in a predicted circRNA_miRNA_mRNA network to infer potential functions via ceRNA regulation."	0.5545
36440268	Frontiers in neuroscience	2022	Potential value of differentially expressed circular RNAs derived from circulating exosomes in the pathogenesis of rat spinal cord injury.			rno_circ_Hbb	Hbb	spinal cord injury / SCI	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR; RNA-seq	"This circulating exosome-derived circRNA (sense-overlapping, host gene Hbb) is up-regulated in SCI rats and was used as a hub in a predicted circRNA_miRNA_mRNA network, suggesting potential ceRNA-related regulatory involvement in SCI."	0.5545
36440268	Frontiers in neuroscience	2022	Potential value of differentially expressed circular RNAs derived from circulating exosomes in the pathogenesis of rat spinal cord injury.			rno_circ_Hbb	Hbb	spinal cord injury / SCI	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR; RNA-seq	"This circulating exosome-derived circRNA (sense-overlapping, host gene Hbb) is up-regulated in SCI rats and was used in a predicted circRNA_miRNA_mRNA network, implying potential ceRNA regulation in SCI."	0.5545
36440268	Frontiers in neuroscience	2022	Potential value of differentially expressed circular RNAs derived from circulating exosomes in the pathogenesis of rat spinal cord injury.			rno_circ_Hbb	Hbb	spinal cord injury / SCI	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR; RNA-seq	"This circulating exosome-derived circRNA (sense-overlapping, host gene Hbb) is up-regulated in SCI rats and was included in a predicted circRNA_miRNA_mRNA interaction network, indicating a potential ceRNA-related regulatory role in SCI."	0.5545
36440268	Frontiers in neuroscience	2022	Potential value of differentially expressed circular RNAs derived from circulating exosomes in the pathogenesis of rat spinal cord injury.			rno_circ_Lrch3	Lrch3	spinal cord injury / SCI	MONDO:0043797	spinal cord injury	down-regulated	RT-qPCR; RNA-seq	"This circulating exosome-derived circRNA (exonic, host gene Lrch3) is down-regulated in SCI rats and was included as a hub in a predicted circRNA_miRNA_mRNA network, suggesting possible involvement via ceRNA regulation."	0.5545
36440268	Frontiers in neuroscience	2022	Potential value of differentially expressed circular RNAs derived from circulating exosomes in the pathogenesis of rat spinal cord injury.			rno_circ_Med13l	Med13l	spinal cord injury / SCI	MONDO:0043797	spinal cord injury	down-regulated	RT-qPCR; RNA-seq	"This circulating exosome-derived circRNA (exonic, host gene Med13l) is down-regulated in SCI rats and was used in a predicted circRNA_miRNA_mRNA network, implying potential ceRNA-based regulation during SCI."	0.5545
36440268	Frontiers in neuroscience	2022	Potential value of differentially expressed circular RNAs derived from circulating exosomes in the pathogenesis of rat spinal cord injury.			rno_circ_Slc38al	Slc38al	spinal cord injury / SCI	MONDO:0043797	spinal cord injury	down-regulated	RT-qPCR; RNA-seq	"This circulating exosome-derived circRNA (exonic, host gene Slc38al) is down-regulated in SCI rats and was incorporated into a predicted circRNA_miRNA_mRNA network, suggesting possible ceRNA-related regulatory involvement in SCI."	0.5545
36440268	Frontiers in neuroscience	2022	Potential value of differentially expressed circular RNAs derived from circulating exosomes in the pathogenesis of rat spinal cord injury.					spinal cord injury / SCI	MONDO:0043797	spinal cord injury	down-regulated	RT-qPCR; RNA-seq	"This circulating exosome-derived circRNA (exonic, host gene Loc103 692) is down-regulated in SCI rats and was included in a predicted circRNA_miRNA_mRNA network to infer potential ceRNA-mediated involvement in SCI."	0.5545
36440268	Frontiers in neuroscience	2022	Potential value of differentially expressed circular RNAs derived from circulating exosomes in the pathogenesis of rat spinal cord injury.		chr4:225251864_225254087+			spinal cord injury / SCI	MONDO:0043797	spinal cord injury	down-regulated	RT-qPCR; RNA-seq	"This circulating exosome-derived intergenic circRNA is down-regulated in SCI rats and was included as a central node in a predicted circRNA_miRNA_mRNA interaction network, suggesting potential involvement through ceRNA-like regulation."	0.5545
36443711	BMC cancer	2022	EIF4A3-induced circBRWD3 promotes tumorigenesis of breast cancer through miR-142-3p_miR-142-5p/RAC1/PAK1 signaling.	hsa_circ_0001936	CircBRWD3	hsa_circ_BRWD3	BRWD3	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circBRWD3 is upregulated in breast cancer and acts as an oncogenic circRNA. It sponges miR-142-3p/miR-142-5p to increase RAC1 and activate RAC1/PAK1 signaling, promoting proliferation and migration/metastasis while inhibiting apoptosis; EIF4A3 positively regulates circBRWD3 biogenesis. High circBRWD3 expression is associated with poor patient prognosis."	0.8171
36443854	Lipids in health and disease	2022	CircLDLR acts as a sponge for miR-667-5p to regulate SIRT1 expression in non-alcoholic fatty liver disease.		circLDLR / circRNA low-density lipoprotein receptor	Mus musculus_circ_LDLR	LDLR	non-alcoholic fatty liver disease / NAFLD	MONDO:0013209	metabolic dysfunction-associated steatotic liver disease	down-regulated	RT-qPCR	"circLDLR is down-regulated in an OA/PA-induced NAFLD hepatocyte model. Its overexpression reduces lipid accumulation and TG/TC levels by promoting autophagic flux, functioning as a ceRNA that sponges miR-667-5p to relieve repression of SIRT1 and thereby modulate autophagy signaling."	0.7009
36444635	"Immunity, inflammation and disease"	2022	Circ_0138960 contributes to lipopolysaccharide-induced periodontal ligament cell dysfunction.	hsa_circ_0138960	Circular RNA_0138960 / circ_0138960	hsa_circ_GDA	GDA	periodontitis	MONDO:0005076	periodontitis	up-regulated	RT-qPCR	"circ_0138960 is up-regulated in periodontitis gingival tissues and in LPS-treated PDLCs. Functionally, circ_0138960 aggravates LPS-induced PDLC injury by reducing proliferation and increasing apoptosis and inflammatory cytokines. Mechanistically, it acts as a ceRNA that sponges miR-518a-5p to upregulate HDAC6."	0.7936
36446351	Aging	2022	The circRNA expression profile of colorectal inflammatory cancer transformation revealed potential predictive biomarkers.	mmu_circ_0008035				colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; RNA-seq	mmu_circ_0008035 is continuously upregulated during inflammation-to-adenoma-to-CRC progression in the AOM-DSS mouse model and is proposed as a potential biomarker and regulator in colorectal tumor development.	0.5219
36446351	Aging	2022	The circRNA expression profile of colorectal inflammatory cancer transformation revealed potential predictive biomarkers.	mmu_circ_0000420				colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; RNA-seq	mmu_circ_0000420 is continuously upregulated during inflammation-to-adenoma-to-CRC progression in the AOM-DSS mouse model and is highlighted as a candidate biomarker for predicting colorectal cancer development.	0.5219
36446351	Aging	2022	The circRNA expression profile of colorectal inflammatory cancer transformation revealed potential predictive biomarkers.	hsa_circ_0101338	hsa_circ0101338 / circ_0101338			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH	"hsa_circ0101338 is upregulated from normal to CRA and further to CRC in clinical tissues and shows strong diagnostic performance by ROC. Mechanistically, it functions as a miRNA sponge in CRC cells, binding miR-661, miR-4755-3p and miR-1273g-3p as supported by RNA pull-down after prediction."	0.6616
36446351	Aging	2022	The circRNA expression profile of colorectal inflammatory cancer transformation revealed potential predictive biomarkers.	hsa_circ_0022426	circ_0022426 / hsa_circRNA_0022426			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH	"hsa_circ_0022426 is upregulated from normal to CRA and further to CRC in clinical tissues and has diagnostic value by ROC. It functions via a ceRNA-like miRNA sponge mechanism in CRC cells, binding miR-635, miR-6851-3p, miR-1227-5p and miR-6774-5p as supported by RNA pull-down following bioinformatic prediction."	0.6616
36446779	Cell death & disease	2022	m6A-modified circFNDC3B inhibits colorectal cancer stemness and metastasis via RNF41-dependent ASB6 degradation.	hsa_circ_0006156	circFNDC3B	hsa_circ_FNDC3B	FNDC3B	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"circFNDC3B is downregulated in colorectal cancer and acts as a tumor suppressor by inhibiting stemness and metastasis. m6A-modified circFNDC3B is exported to the cytoplasm via YTHDC1, binds the RBP FXR2 to stabilize RNF41 mRNA, and enhances RNF41-dependent ubiquitination and degradation of ASB6, thereby restraining malignant phenotypes."	0.8912
36448712	The Kaohsiung journal of medical sciences	2023	Exosomal circNFIX promotes angiogenesis in ovarian cancer via miR-518a-3p/TRIM44 axis.		circNFIX / circ_NFIX	hsa_circ_NFIX		ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"In ovarian cancer, circNFIX is up-regulated and enriched in OC-cell-derived exosomes. Exosomal circNFIX promotes HUVEC proliferation, migration and angiogenesis by sponging miR-518a-3p, thereby increasing TRIM44 and activating the JAK/STAT1 signaling pathway."	0.7277
36453441	Cancer medicine	2023	Hsa-circ-0052001 promotes gastric cancer cell proliferation and invasion via the MAPK pathway.	hsa_circ_0052001	hsa_circ_0052001			Gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"hsa-circ-0052001 is up-regulated in gastric cancer tissues/cells and promotes proliferation, migration/invasion and tumor growth. It functions in part by sponging miR-608 and activating MAPK signaling (ERK/P38/JNK phosphorylation). High expression is associated with worse overall survival, particularly in advanced-stage patients."	0.6778
36453704	Molecular carcinogenesis	2023	Circ-E-Cad encodes a protein that promotes the proliferation and migration of gastric cancer via the TGF-beta/Smad/C-E-Cad/PI3K/AKT pathway.		circ-E-Cad / circular E-cadherin	hsa_circ_CDH1	CDH1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_E_Cad is up-regulated in gastric cancer tissues and cell lines and is mainly localized in the cytoplasm. Functional assays using circ_E_Cad knockdown/overexpression indicate it promotes malignant phenotypes, with effects mediated by its encoded protein C_E_Cad that activates PI3K/AKT and is induced by TGF_beta/Smad signaling."	0.5098
36457055	Journal of neuroinflammation	2022	Scorpion venom peptide HsTx2 suppressed PTZ-induced seizures in mice via the circ_0001293/miR-8114/TGF-beta2 axis.	mmu_circ_0001293	circ_0001293			epilepsy	MONDO:0005027	epilepsy	down-regulated	RT-qPCR; RNA-seq	"In PTZ-induced epilepsy mice and IL-1beta-stimulated astrocytes, circ_0001293 is down-regulated by disease stimuli and restored by HsTx2. circ_0001293 functions as a ceRNA by sponging miR-8114 to de-repress TGF-beta2, thereby reducing inflammatory responses and modulating MAPK and NF-kappaB signaling, contributing to antiseizure effects."	0.5997
36457988	Archives of medical science : AMS	2022	Hsa_circ_0017728 as an oncogene in gastric cancer by sponging miR-149 and modulating the IL-6/STAT3 pathway.	hsa_circ_0017728	hsa_circ_0017-728			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0017728 is up-regulated in gastric carcinoma and promotes proliferation and migration while inhibiting apoptosis. Mechanistically, it functions as a ceRNA sponging miR-149 and thereby activates the IL-6/STAT3 signaling axis; high expression is associated with worse clinicopathologic features and poor survival."	0.8162
36458003	Frontiers in immunology	2022	Transcriptome analysis of differentially expressed circRNAs miRNAs and mRNAs during the challenge of coccidiosis.	gga_circ_0004143	circMGAT5 / circ_0004143	gga_circ_MGAT5	MGAT5	coccidiosis	MONDO:0005707	coccidiosis	up-regulated	RT-qPCR; RNA-seq	"In Eimeria tenella-infected chickens, circMGAT5 is up-regulated and functions as a ceRNA by sponging miR-132c-5p to increase MMD expression. Through this circMGAT5-miR-132c-5p-MMD axis, circMGAT5 inhibits macrophage activation/differentiation (e.g., affects F4/80 and MHC-II), suggesting biomarker potential for chicken coccidiosis."	0.7549
36460954	BMC cardiovascular disorders	2022	Circ_0004104 participates in the regulation of ox-LDL-induced endothelial cells injury via miR-942-5p/ROCK2 axis.	hsa_circ_0004104	Circ_0004104			atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"circ_0004104 is up-regulated in atherosclerosis patient serum and in ox-LDL-treated HUVECs, including in exosomes. Functionally, circ_0004104 promotes ox-LDL-induced endothelial injury (decreased proliferation/angiogenesis and increased apoptosis/inflammation). Mechanistically, it acts as a ceRNA sponging miR-942-5p to increase ROCK2 expression, and can be delivered via exosomes."	0.779
36466608	Frontiers in aging neuroscience	2022	Comprehensive analysis of dysregulated circular RNAs and construction of a ceRNA network involved in the pathology of Alzheimer's disease in a 5_¡Á_FAD mouse model.		circRNA04655	mmu_circ_Elavl2	Elavl2	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR; RNA-seq	"circRNA04655 (host gene Elavl2) is down-regulated in the hippocampus of 5¡ÁFAD AD mice and is included as a key node in a predicted circRNA_miRNA_mRNA ceRNA network, with predicted interaction to miR-669f-5p."	0.4997
36466608	Frontiers in aging neuroscience	2022	Comprehensive analysis of dysregulated circular RNAs and construction of a ceRNA network involved in the pathology of Alzheimer's disease in a 5_¡Á_FAD mouse model.		circRNA00723	mmu_circ_Myt1	Myt1	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR; RNA-seq	"circRNA00723 (host gene Myt1) is down-regulated in the hippocampus of 5¡ÁFAD AD mice and is a key circRNA in the constructed ceRNA network, with predicted interactions to miR-669f-5p and miR-466i-5p."	0.4997
36466608	Frontiers in aging neuroscience	2022	Comprehensive analysis of dysregulated circular RNAs and construction of a ceRNA network involved in the pathology of Alzheimer's disease in a 5_¡Á_FAD mouse model.		circRNA01891			Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR; RNA-seq	"circRNA01891 is up-regulated in the hippocampus of 5¡ÁFAD AD mice, validated by qRT-PCR, and is incorporated into the predicted ceRNA network with a predicted interaction to miR-3470b."	0.4997
36466848	Frontiers in immunology	2022	Circular RNA hsa_circ_0007990 as a blood biomarker for unruptured intracranial aneurysm with aneurysm wall enhancement.	hsa_circ_0007990	hsa_circRNA_0007990 / hsa_circPGAP3_003	hsa_circ_PGAP3	PGAP3	intracranial aneurysms / IA	MONDO:0005291	brain aneurysm	up-regulated	RT-qPCR; Microarray	"hsa_circ_0007990 is up-regulated in peripheral blood of UIA patients, showing a graded increase from healthy controls to UIA without AWE to UIA with AWE. The study proposes it as a blood inflammatory biomarker and builds a predicted circRNA-miRNA-mRNA (ceRNA) network with five miRNAs and inflammatory-response hub genes; RBP binding and protein-coding potential (PER1 superfamily) were also predicted."	0.5963
36467610	Frontiers in cellular neuroscience	2022	Role of hippocampal circKcnk9 in visceral hypersensitivity and anxiety comorbidity of irritable bowel syndrome.		circKcnk9 / circ7685	rno_circ_Kcnk9	Kcnk9	irritable bowel syndrome / IBS	MONDO:0005052	irritable bowel syndrome	up-regulated	RT-qPCR; ISH	"In IBS-like (neonatal CRD) rats, hippocampal CA1 circKcnk9 is up-regulated and promotes synaptic plasticity (enhanced LTP), leading to visceral hypersensitivity and anxiety-like behaviors. Mechanistically, circKcnk9 functions as a miR-124-3p sponge (AGO2/RISC-associated), thereby de-repressing the miR-124-3p target EZH2 and contributing to the disease phenotypes."	0.6528
36468008	Frontiers in genetics	2022	Bioinformatics-based study reveals that AP2M1 is regulated by the circRNA-miRNA-mRNA interaction network and affects Alzheimer's disease.		hsa_circ_002048 			Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	Microarray	"In this bioinformatics analysis of GEO datasets, hsa_circ_002048 was identified as down-regulated in AD blood-related samples. The study proposes a ceRNA network where reduced hsa_circ_002048 is linked to increased hsa-miR-422a/hsa-miR-4784/hsa-miR-3944-3p, which may suppress AP2M1 and contribute to AD pathology."	0.1768
36471741	Journal of hepatocellular carcinoma	2022	"Integrated Analysis of Altered lncRNA, circRNA, microRNA, and mRNA Expression in Hepatocellular Carcinoma Carrying TERT Promoter Mutations."	hsa_circ_0021412				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0021412 is up-regulated in HCC tumors with TERT promoter mutations compared with wildtype TERT promoter tumors, and its differential expression was validated by qPCR in the validation cohort. The study did not define a specific downstream miRNA/mRNA axis or mechanism for hsa_circ_0021412."	0.4032
36471741	Journal of hepatocellular carcinoma	2022	"Integrated Analysis of Altered lncRNA, circRNA, microRNA, and mRNA Expression in Hepatocellular Carcinoma Carrying TERT Promoter Mutations."	hsa_circ_0003154				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RNA-seq	"hsa_circ_0003154 is down-regulated in TERT promoter-mutant HCC and is placed in a circRNA_miRNA_mRNA ceRNA network, where reduced hsa_circ_0003154 may relieve repression of hsa-miR-1260b, associated with lower CLPTM1L and GSTM1 in the constructed axis. This axis is proposed to have carcinogenic potential in the context of TERT promoter mutations."	0.1768
36471741	Journal of hepatocellular carcinoma	2022	"Integrated Analysis of Altered lncRNA, circRNA, microRNA, and mRNA Expression in Hepatocellular Carcinoma Carrying TERT Promoter Mutations."	hsa_circ_0008952				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RNA-seq	"hsa_circ_0008952 is down-regulated in TERT promoter-mutant HCC and is included in a proposed ceRNA axis where it regulates hsa-miR-1260b, with downstream targets including CLPTM1L and GSTM1. The axis is suggested to have carcinogenic potential related to TERT promoter mutations."	0.1768
36471741	Journal of hepatocellular carcinoma	2022	"Integrated Analysis of Altered lncRNA, circRNA, microRNA, and mRNA Expression in Hepatocellular Carcinoma Carrying TERT Promoter Mutations."	hsa_circ_0031584				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RNA-seq	"hsa_circ_0031584 is up-regulated in TERT promoter-mutant HCC and is included in a proposed ceRNA axis hsa_circ_0031584_hsa-miR-214-3p_CD151. Through this axis, it is suggested to contribute to carcinogenic potential, potentially linked to CD151-associated angiogenesis, invasiveness, and metastasis."	0.1768
36474147	Cellular & molecular biology letters	2022	Exosomal miR-628-5p from M1 polarized macrophages hinders m6A modification of circFUT8 to suppress hepatocellular carcinoma progression.		circFUT8	hsa_circ_FUT8	FUT8	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH	"circFUT8 is up-regulated in HCC cell lines and acts oncogenically by promoting proliferation and invasion while inhibiting apoptosis. Mechanistically, cytoplasmic circFUT8 sponges miR-552-3p to increase CHMP4B, and its m6A modification by METTL14 facilitates nuclear export; M1 macrophage-derived exosomal miR-628-5p represses METTL14 to reduce circFUT8 m6A and limit this ceRNA program, suppressing HCC progression."	0.8164
36476239	BMC cancer	2022	Exosome-transmitted circ_002136 promotes hepatocellular carcinoma progression by miR-19a-3p/RAB1A pathway.		circ_002136 / hsa_circCDK11A_001	hsa_circ_CDK11A	CDK11A	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_002136 is up-regulated in HCC tissues/cells and enriched in HCC-derived exosomes, enabling intercellular transfer. Functionally, circ_002136 promotes HCC proliferation, migration/invasion and anti-apoptosis, and its knockdown suppresses xenograft tumor growth. Mechanistically, it acts as a ceRNA sponge for miR-19a-3p to increase RAB1A, and high circ_002136 is associated with poor patient survival."	0.7548
36476986	Communications biology	2022	Circ-CREBBP inhibits sperm apoptosis via the PI3K-Akt signaling pathway by sponging miR-10384 and miR-143-3p.		circ-CREBBP	ssc_circ_CREBBP	CREBBP	male reproductive diseases	MONDO:0003150	male reproductive system disorder	down-regulated	RT-qPCR; RNA-seq	"In boar seminal plasma extracellular vesicles and sperm, circ-CREBBP is higher in the high-motility group and supports sperm motility and survival. Mechanistically, it acts as a ceRNA that sponges miR-10384 and miR-143-3p, thereby increasing MCL1/CREB1/CREBBP (and downstream BCL2) while reducing pro-apoptotic factors such as BAX and CASP3, linked to PI3K/Akt signaling. It is proposed as a potential biomarker/therapeutic target for male reproductive diseases."	0.8246
36477660	Cellular and molecular life sciences : CMLS	2022	Role of hsa_circ_0000280 in regulating vascular smooth muscle cell function and attenuating neointimal hyperplasia via ELAVL1.	hsa_circ_0000280	Circ_280	hsa_circ_HPS5	HPS5	coronary heart disease / CHD	MONDO:0005010	coronary artery disorder	down-regulated	RT-qPCR; ISH; RNA-seq	"hsa_circ_0000280 is down-regulated in CHD PBMCs and atherosclerotic coronary arteries. It binds ELAVL1 and CDKN1A mRNA to promote ELAVL1_CDKN1A interaction, increasing CDKN1A and causing G1/S arrest, thereby inhibiting VSMC proliferation/migration and reducing neointimal hyperplasia in vivo."	0.8354
36494341	Cell death & disease	2022	circPLIN2 promotes clear cell renal cell carcinoma progression by binding IGF2BP proteins and miR-199a-3p.	hsa_circ_0086457	circPLIN2	hsa_circ_PLIN2	PLIN2	clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circPLIN2 (hsa_circ_0086457), derived from PLIN2, is up-regulated in ccRCC and promotes proliferation, migration, invasion, tumor growth and metastasis. It binds IGF2BP1/2/3 (via KH domains) to enhance c-Myc and MARCKSL1 mRNA stability and also sponges miR-199a-3p to de-repress ZEB1. High circPLIN2 expression correlates with advanced stage and worse overall survival and shows diagnostic potential by ROC analysis."	0.8957
36495291	The Kaohsiung journal of medical sciences	2023	"CircNFIX stimulates the proliferation, invasion, and stemness properties of ovarian cancer cells by enhancing SH3RF3 mRNA stability via binding LIN28B."	hsa_circ_0049658	circNFIX / circular nuclear factor IX	hsa_circ_NFIX	NFIX	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circNFIX is up-regulated in ovarian cancer tissues and cell lines and promotes proliferation, migration/invasion, EMT-like changes, and stemness. Mechanistically, circNFIX binds the RBP LIN28B to enhance SH3RF3 mRNA stability/translation, thereby maintaining SH3RF3 expression and driving malignant phenotypes."	0.762
36497052	Cells	2022	CircZXDC Promotes Vascular Smooth Muscle Cell Transdifferentiation via Regulating miRNA-125a-3p/ABCC6 in Moyamoya Disease.	hsa_circ_0067130	circZXDC / circ0067130	hsa_circ_ZXDC	ZXDC	Moyamoya disease / MMD	MONDO:0016820	Moyamoya disease	up-regulated	RT-qPCR	"circZXDC is up-regulated in MMD plasma and promotes VSMC transdifferentiation toward a synthetic phenotype, enhancing proliferation and migration. Mechanistically, it sponges miR-125a-3p to upregulate ABCC6 and induce ER stress, contributing to intima hyperplasia; it also shows diagnostic potential by ROC analysis."	0.7126
36497344	Cancers	2022	circRNF10 Regulates Tumorigenic Properties and Natural Killer Cell-Mediated Cytotoxicity against Breast Cancer through the miR-934/PTEN/PI3k-Akt Axis.	hsa_circ_0028899	circRNF10	hsa_circ_RNF10	RNF10	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	"circRNF10 (hsa_circ_0028899) is down-regulated in breast cancer and higher expression predicts better prognosis. It suppresses breast cancer cell proliferation/migration/invasion and enhances NK-cell cytotoxicity by sponging miR-934, thereby upregulating PTEN and inhibiting PI3K/AKT/MICA signaling; it also reduces tumor growth in xenografts."	0.8684
36499715	International journal of molecular sciences	2022	Circ_0011129 Encapsulated by the Small Extracellular Vesicles Derived from Human Stem Cells Ameliorate Skin Photoaging.	hsa_circ_0011129	circ_0011129			skin photoaging	MONDO:0005093	skin disorder	unknown	RT-qPCR	"In UVA-induced HDF photoaging models, circ_0011129 delivered via hADSC-derived sEVs (3D-circ-sEVs) alleviates photoaging by acting as a sponge for miR-6732-5p. This reduces senescence markers and photoaging-related genes (e.g., MMP1/MMP3/Cathepsin K) and promotes collagen and elastin expression, with additional protection against oxidative stress."	0.6253
36512324	Cancer immunology research	2023	Extracellular Vesicle-Packaged circATP2B4 Mediates M2 Macrophage Polarization via miR-532-3p/SREBF1 Axis to Promote Epithelial Ovarian Cancer Metastasis.	hsa_circ_0000173	circATP2B4	hsa_circ_ATP2B4	ATP2B4	epithelial ovarian cancer / EOC	MONDO:0005140	ovarian carcinoma	up-regulated	RT-qPCR; Northern Blot; ISH; RNA-seq	"circATP2B4 is up-regulated in epithelial ovarian cancer and is enriched in tumor-cell extracellular vesicles that are taken up by macrophages. It functions as a ceRNA sponging miR-532-3p to increase SREBF1 and activate PI3Kalpha/AKT signaling, promoting M2 macrophage polarization, immunosuppression, EMT, and peritoneal metastasis."	0.8441
36513974	BMC genomics	2022	Identification and characterization of non-coding RNA networks in infected macrophages revealing the pathogenesis of F. nucleatum-associated diseases.	hsa_circ_0078617				F. nucleatum infection	MONDO:0006765	Fusobacterium infectious disease	unknown	RT-qPCR; RNA-seq	"hsa_circ_0078617 is a differentially expressed circRNA in F. nucleatum-infected macrophages and is proposed to act as a ceRNA for miR-150-5p, thereby indirectly regulating AKT2 within a circRNA-miRNA-mRNA network related to immune responses."	0.2465
36513974	BMC genomics	2022	Identification and characterization of non-coding RNA networks in infected macrophages revealing the pathogenesis of F. nucleatum-associated diseases.	hsa_circ_0069227				F. nucleatum infection	MONDO:0006765	Fusobacterium infectious disease	unknown	RT-qPCR; RNA-seq	"hsa_circ_0069227 is included in the inferred circRNA-miR-150-5p-AKT2 ceRNA axis in F. nucleatum-infected macrophages, suggesting a role in immune-response-related regulatory networks."	0.2465
36513974	BMC genomics	2022	Identification and characterization of non-coding RNA networks in infected macrophages revealing the pathogenesis of F. nucleatum-associated diseases.	hsa_circ_0084089				F. nucleatum infection	MONDO:0006765	Fusobacterium infectious disease	unknown	RT-qPCR; RNA-seq	"hsa_circ_0084089 is part of the inferred hsa_circ_0084089/miR-150-5p/AKT2 ceRNA axis in F. nucleatum-infected macrophages, suggesting involvement in immune-response-related regulatory networks."	0.2465
36513974	BMC genomics	2022	Identification and characterization of non-coding RNA networks in infected macrophages revealing the pathogenesis of F. nucleatum-associated diseases.	hsa_circ_0001165				F. nucleatum infection	MONDO:0006765	Fusobacterium infectious disease	unknown	RT-qPCR; RNA-seq	"hsa_circ_0001165 is identified as a core circRNA in F. nucleatum-infected macrophages and is implicated in a ceRNA network where it may sponge miR-146a-3p to indirectly regulate MITF, potentially affecting immune-response-related processes."	0.2465
36513974	BMC genomics	2022	Identification and characterization of non-coding RNA networks in infected macrophages revealing the pathogenesis of F. nucleatum-associated diseases.	hsa_circ_0008460				F. nucleatum infection	MONDO:0006765	Fusobacterium infectious disease	unknown	RT-qPCR; RNA-seq	"hsa_circ_0008460 is included in the proposed circRNA-miR-146a-3p-MITF ceRNA axis in F. nucleatum-infected macrophages, suggesting a role in immune-related regulatory mechanisms via indirect modulation of MITF."	0.2465
36513974	BMC genomics	2022	Identification and characterization of non-coding RNA networks in infected macrophages revealing the pathogenesis of F. nucleatum-associated diseases.	hsa_circ_0001118				F. nucleatum infection	MONDO:0006765	Fusobacterium infectious disease	unknown	RT-qPCR; RNA-seq	"hsa_circ_0001118 is included in a proposed ceRNA regulatory axis in which it may sponge miR-146a-3p to indirectly modulate MITF in F. nucleatum-infected macrophages, potentially contributing to immune-response dysregulation associated with F. nucleatum."	0.2465
36514094	Molecular cancer	2022	circCYP24A1 facilitates esophageal squamous cell carcinoma progression through binding PKM2 to regulate NF-kappaB-induced CCL5 secretion.	hsa_circ_0060927	circCYP24A1	hsa_circ_CYP24A1	CYP24A1	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circCYP24A1 (hsa_circ_0060927), derived from CYP24A1, is up-regulated in ESCC and promotes proliferation, migration, invasion, colony formation, and xenograft tumor growth. Mechanistically, it binds PKM2 to enhance NF-kappaB activation (p65 phosphorylation), increasing CCL5 secretion; high circCYP24A1 is associated with shorter overall survival and serves as a prognostic biomarker/target."	0.8611
36514216	Acta biochimica et biophysica Sinica	2022	circ-BPTF serves as a miR-486-5p sponge to regulate CEMIP and promotes hypoxic pulmonary arterial smooth muscle cell proliferation in COPD.	hsa_circ_0045462	circ-BPTF	hsa_circ_BPTF	BPTF	chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR; Microarray	"circ-BPTF is up-regulated in pulmonary arteries of COPD patients and is induced by hypoxia in hPASMCs. It promotes hypoxia-driven PASMC proliferation by sponging miR-486-5p, thereby de-repressing CEMIP and enhancing downstream AKT-related pro-proliferative signaling."	0.753
36514862	Journal of clinical laboratory analysis	2023	Circular RNAs expression profiles and bioinformatics analysis in bronchopulmonary dysplasia.	hsa_circ_0007054		hsa_circ_TMEM50A	TMEM50A	Bronchopulmonary dysplasia / BPD	MONDO:0019091	bronchopulmonary dysplasia	up-regulated	RT-qPCR; Microarray	"hsa_circ_0007054 is up-regulated in PBMCs from VLBW infants with moderate to severe BPD in the early post-birth period and was validated by RT-qPCR after microarray screening. It was part of the circRNA set used for downstream ceRNA-network-based bioinformatics analyses, though no specific miRNA/mRNA axis was reported for this circRNA."	0.4032
36514862	Journal of clinical laboratory analysis	2023	Circular RNAs expression profiles and bioinformatics analysis in bronchopulmonary dysplasia.	hsa_circ_0057950		hsa_circ_CREB1	CREB1	Bronchopulmonary dysplasia / BPD	MONDO:0019091	bronchopulmonary dysplasia	up-regulated	RT-qPCR; Microarray	"hsa_circ_0057950 is up-regulated in PBMCs from VLBW infants with moderate to severe BPD and validated by RT-qPCR. The study¡¯s ceRNA analysis suggests it may sponge hsa-miR-4688 and hsa-miR-3192-5p to regulate ERG and CHIT1, and it is discussed alongside activation of IL1R1 in the inflammatory context of BPD."	0.4032
36514862	Journal of clinical laboratory analysis	2023	Circular RNAs expression profiles and bioinformatics analysis in bronchopulmonary dysplasia.	hsa_circ_0120151				Bronchopulmonary dysplasia / BPD	MONDO:0019091	bronchopulmonary dysplasia	up-regulated	RT-qPCR; Microarray	"hsa_circ_0120151 is up-regulated in PBMCs from VLBW infants with moderate to severe BPD and was validated by RT-qPCR following microarray profiling. It was included as a circRNA node for constructing the study¡¯s ceRNA network, but no specific miRNA/mRNA targets were detailed for this circRNA in the provided text."	0.4032
36514862	Journal of clinical laboratory analysis	2023	Circular RNAs expression profiles and bioinformatics analysis in bronchopulmonary dysplasia.	hsa_circ_0050386		hsa_circ_ANKRD27	ANKRD27	Bronchopulmonary dysplasia / BPD	MONDO:0019091	bronchopulmonary dysplasia	up-regulated	RT-qPCR; Microarray	hsa_circ_0050386 is up-regulated in PBMCs from VLBW infants with moderate to severe BPD and was validated by RT-qPCR. The paper did not provide a specific downstream miRNA/mRNA axis or pathway mechanism for this circRNA.	0.3588
36515567	Journal of cellular and molecular medicine	2023	Circ_0000052/miR-382-3p axis induces PD-L1 expression and regulates cell proliferation and immune evasion in head and neck squamous cell carcinoma.	hsa_circ_0000052	circ_0000052 / circ_AGO1	hsa_circ_AGO1	AGO1	head and neck squamous cell carcinoma / HNSCC	MONDO:0010150	head and neck squamous cell carcinoma	up-regulated	RT-qPCR	"circ_0000052 (circ_AGO1) is upregulated in HNSCC tissues and cell lines and mainly localizes in the cytoplasm. It promotes malignant phenotypes and tumor growth by acting as a ceRNA sponge for miR-382-3p, thereby increasing PD-L1 expression and contributing to HNSCC progression/immune evasion."	0.8119
36519785	Cancer science	2023	circEZH2E2 /E3 is a dual suppressor of miR363/miR708 to promote EZH2 expression and prostate cancer progression.	hsa_circ_0006357	circEZH2E2-E3	hsa_circ_EZH2	EZH2	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; ISH	"circEZH2E2/E3 (hsa_circ_0006357), derived from EZH2 exons 2_3, is up-regulated in prostate cancer and mainly localized in the cytoplasm. It sponges miR363 and miR708 to relieve their repression of EZH2, leading to increased EZH2/H3K27me3, repression of CDH1 and DAB2IP, and promotion of proliferation, migration/invasion, angiogenesis, and xenograft growth. High circEZH2E2/E3 is associated with tumor progression and poor progression-free and disease-specific survival."	0.8841
36519785	Cancer science	2023	circEZH2E2 /E3 is a dual suppressor of miR363/miR708 to promote EZH2 expression and prostate cancer progression.	hsa_circ_0008324	circEZH2E2_E4	hsa_circ_EZH2	EZH2	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	circEZH2E2-E4 (hsa_circ_0008324) is one of the EZH2-derived circRNAs detected in prostate cancer cell lines and is overexpressed in PCa cells and tissue samples. No functional/mechanistic or clinical analyses were reported for this circRNA beyond expression profiling.	0.5129
36519785	Cancer science	2023	circEZH2E2 /E3 is a dual suppressor of miR363/miR708 to promote EZH2 expression and prostate cancer progression.	hsa_circ_0082843	circEZH2E2_E8	hsa_circ_EZH2	EZH2	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circEZH2E2-E8 (hsa_circ_0082843) is an EZH2-derived circRNA detected in prostate cancer cell lines and is overexpressed in PCa cells and tissue samples. The study did not further characterize its mechanism, functional phenotypes, or clinical prognostic value."	0.5129
36522683	Journal of experimental & clinical cancer research : CR	2022	IGF2BP2-induced circRUNX1 facilitates the growth and metastasis of esophageal squamous cell carcinoma through miR-449b-5p/FOXP3 axis.	hsa_circ_0002360	circRUNX1	hsa_circ_RUNX1	RUNX1	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circRUNX1 is up-regulated in ESCC and promotes proliferation and metastasis. It acts as a ceRNA by sponging miR-449b-5p to increase FOXP3 expression, and its stability is enhanced by IGF2BP2 binding in an m6A-dependent manner. circRUNX1 shows diagnostic potential (ROC AUC 0.894) and correlates with advanced TNM stage and poor differentiation."	0.8837
36523430	Frontiers in neuroscience	2022	Machine learning-based identification of the novel circRNAs circERBB2 and circCHST12 as potential biomarkers of intracerebral hemorrhage.		circERBB2	hsa_circ_ERBB2	ERBB2	intracerebral hemorrhage / ICH	MONDO:0013792	intracerebral hemorrhage	down-regulated	RT-qPCR; RNA-seq	"circERBB2 is a novel ERBB2-derived circRNA that is down-regulated in peripheral blood from ICH patients. It was validated as a bona fide circRNA and shows diagnostic value for distinguishing ICH from healthy controls (and also differs between ICH and IS), especially when combined with circCHST12 and clinical risk factors."	0.6841
36523430	Frontiers in neuroscience	2022	Machine learning-based identification of the novel circRNAs circERBB2 and circCHST12 as potential biomarkers of intracerebral hemorrhage.		circCHST12	hsa_circ_CHST12	CHST12	intracerebral hemorrhage / ICH	MONDO:0013792	intracerebral hemorrhage	down-regulated	RT-qPCR; RNA-seq	"circCHST12 is a novel CHST12-derived circRNA that is down-regulated in peripheral blood from ICH patients. It was experimentally validated as a circular RNA and shows diagnostic value for distinguishing ICH from healthy controls and ICH from IS, particularly in combination with circERBB2 and clinical risk factors."	0.6841
36523430	Frontiers in neuroscience	2022	Machine learning-based identification of the novel circRNAs circERBB2 and circCHST12 as potential biomarkers of intracerebral hemorrhage.	hsa_circ_0005505		hsa_circ_IRAK3	IRAK3	intracerebral hemorrhage / ICH	MONDO:0013792	intracerebral hemorrhage	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0005505 is up-regulated in peripheral blood from ICH patients and is part of a circRNA signature that improves diagnostic discrimination of ICH from healthy controls and from IS when combined with circERBB2 and circCHST12.	0.5047
36523430	Frontiers in neuroscience	2022	Machine learning-based identification of the novel circRNAs circERBB2 and circCHST12 as potential biomarkers of intracerebral hemorrhage.	hsa_circ_0001707			Null	intracerebral hemorrhage / ICH	MONDO:0013792	intracerebral hemorrhage	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0001707 is up-regulated in ICH peripheral blood and was confirmed by RT-qPCR. Higher expression is associated with increased odds of ICH occurrence in adjusted logistic regression.	0.4032
36523430	Frontiers in neuroscience	2022	Machine learning-based identification of the novel circRNAs circERBB2 and circCHST12 as potential biomarkers of intracerebral hemorrhage.	hsa_circ_0027725		hsa_circ_PLXNC1	PLXNC1	intracerebral hemorrhage / ICH	MONDO:0013792	intracerebral hemorrhage	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0027725 is up-regulated in ICH peripheral blood and was confirmed by RT-qPCR. Higher expression is associated with increased odds of ICH occurrence in adjusted logistic regression.	0.4032
36523430	Frontiers in neuroscience	2022	Machine learning-based identification of the novel circRNAs circERBB2 and circCHST12 as potential biomarkers of intracerebral hemorrhage.	hsa_circ_0000914		hsa_circ_FKBP8	FKBP8	intracerebral hemorrhage / ICH	MONDO:0013792	intracerebral hemorrhage	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0000914 is down-regulated in ICH peripheral blood and was confirmed by RT-qPCR. Higher expression is associated with reduced odds of ICH occurrence in adjusted logistic regression.	0.4032
36524216	"Drug design, development and therapy"	2022	"Keloid Patient Plasma-Derived Exosomal hsa_circ_0020792 Promotes Normal Skin Fibroblasts Proliferation, Migration, and Fibrogenesis via Modulating miR-193a-5p and Activating TGF-beta1/Smad2/3 Signaling."	hsa_circ_0020792				keloid	MONDO:0005348	keloid	up-regulated	RT-qPCR	"Plasma-derived exosomal hsa_circ_0020792 is up-regulated in keloid patients and keloid fibroblasts. It promotes normal skin fibroblast viability/proliferation, migration, ECM production and fibrogenesis while inhibiting apoptosis, at least partly by modulating miR-193a-5p and activating TGF-beta1/Smad2/3 signaling."	0.5732
36526959	BMC genomics	2022	Deregulated RNAs involved in sympathetic regulation of sepsis-induced acute lung injury based on whole transcriptome sequencing.	mmu_circ_0000246	circRNA-0000246			sepsis-induced acute lung injury	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR; RNA-seq	mmu_circ_0000246 was up-regulated in LPS-induced ALI (vs Ctrl) and reduced after sympathetic denervation (SD+ALI vs ALI). It was one of the DE circRNAs whose expression change was confirmed by RT-qPCR and was suggested to be associated with inflammatory signaling pathways by enrichment analysis.	0.4625
36526959	BMC genomics	2022	Deregulated RNAs involved in sympathetic regulation of sepsis-induced acute lung injury based on whole transcriptome sequencing.	mmu_circ_003646	circRNA-003646			sepsis-induced acute lung injury	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR; RNA-seq	mmu_circ_003646 was up-regulated in LPS-induced ALI (vs Ctrl) and reduced after sympathetic denervation (SD+ALI vs ALI). Its differential expression was validated by RT-qPCR and enrichment analysis suggested association with inflammatory signaling pathways.	0.4625
36526959	BMC genomics	2022	Deregulated RNAs involved in sympathetic regulation of sepsis-induced acute lung injury based on whole transcriptome sequencing.	mmu_circ_0013022	circRNA-0013022			sepsis-induced acute lung injury	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR; RNA-seq	mmu_circ_0013022 was up-regulated in LPS-induced ALI (vs Ctrl) and reduced after sympathetic denervation (SD+ALI vs ALI). Its differential expression was validated by RT-qPCR and enrichment analysis suggested association with inflammatory signaling pathways.	0.4625
36530171	Cancer medicine	2023	Circular RNA hsa_circ_0004689 (circSWT1) promotes NSCLC progression via the miR-370-3p/SNAIL axis by inducing cell epithelial-mesenchymal transition (EMT).	hsa_circ_0004689	circSWT1	hsa_circ_SWT1	SWT1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"In NSCLC, circSWT1 (hsa_circ_0004689) is upregulated and promotes tumor growth, invasion, migration, metastasis and EMT. It acts as a miR-370-3p sponge to derepress SNAIL, and SNAIL knockout reverses circSWT1-driven phenotypes. High circSWT1 expression is associated with poor prognosis."	0.8815
36531251	Frontiers in genetics	2022	Identification of human placenta-derived circular RNAs and autophagy related circRNA-miRNA-mRNA regulatory network in gestational diabetes mellitus.		circCDH2	hsa_circ_CDH2		gestational diabetes mellitus / GDM	MONDO:0005406	gestational diabetes	up-regulated	RT-qPCR; RNA-seq	"In GDM placentas, circCDH2 is suggested to be up-regulated and may promote autophagy by acting as a ceRNA that sponges miR-33b-3p, thereby relieving repression of ULK1 and increasing ULK1 expression/activation."	0.4474
36531251	Frontiers in genetics	2022	Identification of human placenta-derived circular RNAs and autophagy related circRNA-miRNA-mRNA regulatory network in gestational diabetes mellitus.		circDOCK1	hsa_circ_DOCK1	DOCK1	gestational diabetes mellitus / GDM	MONDO:0005406	gestational diabetes	up-regulated	RT-qPCR; RNA-seq	circDOCK1 was identified by RNA-seq as significantly up-regulated in GDM placentas and its differential expression was validated by qRT-PCR in the clinical validation cohort.	0.4773
36531251	Frontiers in genetics	2022	Identification of human placenta-derived circular RNAs and autophagy related circRNA-miRNA-mRNA regulatory network in gestational diabetes mellitus.		circCHD2	hsa_circ_CHD2	CHD2	gestational diabetes mellitus / GDM	MONDO:0005406	gestational diabetes	up-regulated	RT-qPCR; RNA-seq	circCHD2 was identified as significantly up-regulated in GDM placentas; it was validated by qRT-PCR and further used to demonstrate circRNA properties such as RNase R resistance and higher stability compared with its linear transcript.	0.5909
36531251	Frontiers in genetics	2022	Identification of human placenta-derived circular RNAs and autophagy related circRNA-miRNA-mRNA regulatory network in gestational diabetes mellitus.		circPSD3	hsa_circ_PSD3		gestational diabetes mellitus / GDM	MONDO:0005406	gestational diabetes	up-regulated	RT-qPCR; RNA-seq	"circPSD3 was identified and validated as an up-regulated circRNA in GDM placentas, but no specific downstream mechanism or function was experimentally characterized in this paper."	0.4773
36531251	Frontiers in genetics	2022	Identification of human placenta-derived circular RNAs and autophagy related circRNA-miRNA-mRNA regulatory network in gestational diabetes mellitus.		circANKIB1	hsa_circ_ANKIB1		gestational diabetes mellitus / GDM	MONDO:0005406	gestational diabetes	up-regulated	RT-qPCR; RNA-seq	"circANKIB1 was identified and validated as an up-regulated circRNA in GDM placentas, without further mechanistic characterization."	0.4773
36531251	Frontiers in genetics	2022	Identification of human placenta-derived circular RNAs and autophagy related circRNA-miRNA-mRNA regulatory network in gestational diabetes mellitus.		circCD2AP	hsa_circ_CD2AP		gestational diabetes mellitus / GDM	MONDO:0005406	gestational diabetes	up-regulated	RT-qPCR; RNA-seq	"circCD2AP was identified and validated as an up-regulated circRNA in GDM placentas, without further mechanistic characterization."	0.4773
36531251	Frontiers in genetics	2022	Identification of human placenta-derived circular RNAs and autophagy related circRNA-miRNA-mRNA regulatory network in gestational diabetes mellitus.		circTRIM35	hsa_circ_TRIM35		gestational diabetes mellitus / GDM	MONDO:0005406	gestational diabetes	up-regulated	RT-qPCR; RNA-seq	"circTRIM35 was identified and validated as an up-regulated circRNA in GDM placentas, without further mechanistic characterization."	0.4773
36531251	Frontiers in genetics	2022	Identification of human placenta-derived circular RNAs and autophagy related circRNA-miRNA-mRNA regulatory network in gestational diabetes mellitus.		circPMS1	hsa_circ_PMS1		gestational diabetes mellitus / GDM	MONDO:0005406	gestational diabetes	down-regulated	RT-qPCR; RNA-seq	"circPMS1 was identified and validated as a down-regulated circRNA in GDM placentas, without further mechanistic characterization."	0.4773
36531251	Frontiers in genetics	2022	Identification of human placenta-derived circular RNAs and autophagy related circRNA-miRNA-mRNA regulatory network in gestational diabetes mellitus.		circZFAT	hsa_circ_ZFAT		gestational diabetes mellitus / GDM	MONDO:0005406	gestational diabetes	down-regulated	RT-qPCR; RNA-seq	"circZFAT was identified and validated as down-regulated in GDM placentas, and was additionally used to demonstrate that circRNAs lack polyA+ tails (not amplified from polyA+ RNA-derived cDNA)."	0.4773
36531251	Frontiers in genetics	2022	Identification of human placenta-derived circular RNAs and autophagy related circRNA-miRNA-mRNA regulatory network in gestational diabetes mellitus.		circPAPPA	hsa_circ_PAPPA		gestational diabetes mellitus / GDM	MONDO:0005406	gestational diabetes	down-regulated	RT-qPCR; RNA-seq	"circPAPPA was identified and validated as down-regulated in GDM placentas, and was additionally used to demonstrate that circRNAs lack polyA+ tails (not amplified from polyA+ RNA-derived cDNA)."	0.4773
36531251	Frontiers in genetics	2022	Identification of human placenta-derived circular RNAs and autophagy related circRNA-miRNA-mRNA regulatory network in gestational diabetes mellitus.		circBPTF	hsa_circ_BPTF		gestational diabetes mellitus / GDM	MONDO:0005406	gestational diabetes	down-regulated	RT-qPCR; RNA-seq	"circBPTF was identified and validated as a down-regulated circRNA in GDM placentas, without further mechanistic characterization."	0.4773
36531251	Frontiers in genetics	2022	Identification of human placenta-derived circular RNAs and autophagy related circRNA-miRNA-mRNA regulatory network in gestational diabetes mellitus.		circPGD6	hsa_circ_PGD6		gestational diabetes mellitus / GDM	MONDO:0005406	gestational diabetes	down-regulated	RT-qPCR; RNA-seq	"circPGD6 was identified and validated as a down-regulated circRNA in GDM placentas, without further mechanistic characterization."	0.4773
36531251	Frontiers in genetics	2022	Identification of human placenta-derived circular RNAs and autophagy related circRNA-miRNA-mRNA regulatory network in gestational diabetes mellitus.		circZNF131	hsa_circ_ZNF131		gestational diabetes mellitus / GDM	MONDO:0005406	gestational diabetes	down-regulated	RT-qPCR; RNA-seq	"circZNF131 was identified and validated as a down-regulated circRNA in GDM placentas, without further mechanistic characterization."	0.4773
36532732	Frontiers in pharmacology	2022	Circular RNA-related CeRNA network and prognostic signature for patients with oral squamous cell carcinoma.	hsa_circ_0005991		hsa_circ_APBB2	APBB2	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005991 is up-regulated in OSCC/HNSCC samples and cell lines. Knockdown of hsa_circ_0005991 in CAL27 cells suppresses proliferation, migration, and invasion in vitro, indicating an oncogenic role. The study did not report a validated downstream miRNA/mRNA regulatory axis specific to hsa_circ_0005991."	0.5751
36533129	Frontiers in molecular neuroscience	2022	Circ-Vps41 positively modulates Syp and its overexpression improves memory ability in aging mice.		circ-Vps41 / circVps41	mmu_circ_Vps41	Vps41	aging			down-regulated	RT-qPCR; ISH	"In D-galactose-induced aging models, circ-Vps41 is down-regulated in hippocampus and HT22 cells. circ-Vps41 overexpression improves synaptic plasticity and memory performance by acting as a miR-24-3p sponge to increase Syp expression (miR-24-3p/Syp axis)."	0.6111
36536378	Journal of translational medicine	2022	Urinary exosomal hsa_circ_0001250 as a novel diagnostic biomarker of idiopathic membranous nephropathy.	hsa_circ_0001250		hsa_circ_GRAMD4	GRAMD4	idiopathic membranous nephropathy / IMN	MONDO:0013860	idiopathic membranous glomerulonephritis	up-regulated	RT-qPCR; RNA-seq	"Urinary exosomal hsa_circ_0001250 is significantly up-regulated in IMN and correlates with proteinuria. It shows diagnostic value for distinguishing IMN from healthy controls and INS, and is predicted to act via a circRNA_miRNA_mRNA (ceRNA) network involving hsa-miR-639 and hsa-miR-4449 with downstream targets such as S1PR5 and STAT3."	0.6841
36536414	Molecular cancer	2022	CircNTNG1 inhibits renal cell carcinoma progression via HOXA5-mediated epigenetic silencing of Slug.	hsa_circ_0002286	CircNTNG1	hsa_circ_NTNG1	NTNG1	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	down-regulated	RT-qPCR; RNA-seq; Microarray	"CircNTNG1 is down-regulated in RCC and functions as a tumor suppressor by inhibiting migration/invasion and metastasis. Mechanistically, it sponges miR-19b-3p to de-repress HOXA5, which then epigenetically silences SNAI2 (Slug) via DNMT3A/DNMT3L-mediated promoter methylation, suppressing EMT. Clinically, low circNTNG1 correlates with advanced stage/grade and worse OS/RFS, and circNTNG1 is an independent prognostic factor."	0.8921
36537128	Technology in cancer research & treatment	2022	Comprehensive Analysis of Circular RNA Expression Profiles in Gefitinib-Resistant Lung Adenocarcinoma Patients.	hsa_circ_0030591				lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0030591 is up-regulated in peripheral plasma from LUAD/NSCLC patients with acquired gefitinib resistance. It was selected from microarray DECs, incorporated into a predicted circRNA_miRNA network (miRanda), and proposed as a candidate liquid-biopsy biomarker for EGFR-TKI resistance monitoring."	0.4032
36537128	Technology in cancer research & treatment	2022	Comprehensive Analysis of Circular RNA Expression Profiles in Gefitinib-Resistant Lung Adenocarcinoma Patients.	hsa_circ_0040348				lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0040348 is up-regulated in peripheral plasma from LUAD/NSCLC patients with acquired gefitinib resistance. It was selected from microarray DECs, included in a predicted circRNA_miRNA network related to PI3K-Akt signaling, and proposed as a candidate liquid-biopsy biomarker for EGFR-TKI resistance monitoring."	0.4032
36539368	Anti-cancer drugs	2023	Circ-ABCC4 contributes to prostate cancer progression and radioresistance by mediating miR-1253/SOX4 cascade.		circ-ABCC4	hsa_circ_ABCC4	ABCC4	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circ-ABCC4 is up-regulated in prostate cancer tissues and cell lines and promotes malignant progression and radioresistance while inhibiting apoptosis. Mechanistically, circ-ABCC4 sponges miR-1253 to increase SOX4 expression, forming a circ-ABCC4/miR-1253/SOX4 regulatory axis associated with poor patient survival."	0.7221
36539702	BMC gastroenterology	2022	The hsa_circ_0039857/miR-338-3p/RAB32 axis promotes the malignant progression of colorectal cancer.	hsa_circ_0039857	circ_0039857	hsa_circ_RANBP10	RANBP10	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0039857 is up-regulated in colorectal cancer tissues and cell lines and shows diagnostic potential by ROC analysis. Functionally, circ_0039857 promotes CRC malignant progression by enhancing proliferation and inhibiting apoptosis. Mechanistically, it acts as a ceRNA that sponges miR-338-3p to increase RAB32 expression."	0.8287
36539807	Cancer cell international	2022	Increased expression of miR-194-5p through the circPVRL3/miR-194-5p/SOCS2 axis promotes proliferation and metastasis in pancreatic ductal adenocarcinoma by activating the PI3K/AKT signaling pathway.	hsa_circ_0004639	circPVRL3 / cirPVRL3	hsa_circ_PVRL3	PVRL3	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	down-regulated	Microarray	"circPVRL3 is downregulated in PDAC and functions as a ceRNA that sponges miR-194-5p, thereby relieving repression of SOCS2 and reducing PI3K/AKT pathway activation. Loss of circPVRL3 promotes PDAC cell proliferation and migration, while circPVRL3 overexpression suppresses these phenotypes in vitro and in xenograft models."	0.8415
36541023	Journal of cellular and molecular medicine	2023	Circular RNA CircSLC8A1 contributes to osteogenic differentiation in hBMSCs via CircSLC8A1/miR-144-3p/RUNX1 in periprosthetic osteolysis.	hsa_circ_0000994	CircSLC8A1	hsa_circ_SLC8A1	SLC8A1	periprosthetic osteolysis / PPOL	MONDO:0005381	bone disorder	down-regulated	RT-qPCR	"CircSLC8A1 is down-regulated in PPOL periprosthetic tissues and in Ti particle_induced PPOL cell models. Functionally, it promotes osteogenic differentiation and suppresses apoptosis in hBMSCs. Mechanistically, it acts as a ceRNA by sponging miR-144-3p to derepress RUNX1 (CircSLC8A1/miR-144-3p/RUNX1), thereby alleviating PPOL in vivo."	0.8203
36541023	Journal of cellular and molecular medicine	2023	Circular RNA CircSLC8A1 contributes to osteogenic differentiation in hBMSCs via CircSLC8A1/miR-144-3p/RUNX1 in periprosthetic osteolysis.	mmu_circ_0000823		mmu_circ_SLC8A1	SLC8A1	periprosthetic osteolysis / PPOL	MONDO:0005381	bone disorder	unknown	RT-qPCR	"In the PPOL mouse model, intra-articular AAV-mediated overexpression of mmu_circ_0000823 restores osteogenic marker expression (RUNX1, OPN, OCN) and alleviates osteolysis. The study does not directly test mmu_circ_0000823 interactions with miR-144-3p/RUNX1 as a molecular axis, but uses it as the mouse homolog to functionally support CircSLC8A1¡¯s protective role in vivo."	0.5358
36541909	Aging	2022	Role of m6A modification and novel circ_0066715/ miR-486-5p/ ETS1 axis in rheumatoid arthritis macrophage polarization progression.	hsa_circ_0066715	circ_0066715			rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	down-regulated	RT-qPCR; RNA-seq	"circ_0066715 is down-regulated in rheumatoid arthritis and its overexpression suppresses RA-FLS proliferation/migration and alleviates inflammatory M1 macrophage polarization. Mechanistically, it sponges miR-486-5p to de-repress ETS1 and also affects WTAP-mediated m6A regulation of ETS1, linking ceRNA regulation with m6A-associated macrophage polarization in RA."	0.8561
36542990	Translational oncology	2023	circ-ZEB1 regulates epithelial-mesenchymal transition and chemotherapy resistance of colorectal cancer through acting on miR-200c-5p.	hsa_circ_0000229	circ-ZEB1	hsa_circ_ZEB1	ZEB1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circ-ZEB1 (hsa_circ_0000229), derived from ZEB1, is up-regulated in colorectal cancer tissues and promotes malignant phenotypes including proliferation, migration/invasion, tumorigenesis/metastasis, EMT, and resistance to oxaliplatin and 5-FU. Mechanistically, it functions as a ceRNA by sponging miR-200c-5p/miR-200c and thereby relieving repression of BMI1; knockdown phenotypes are rescued by miR-200c inhibition."	0.7953
36544920	Laryngoscope investigative otolaryngology	2022	CircBFAR correlates with poor prognosis and promotes laryngeal squamous cell cancer progression through miR-31-5p/COL5A1 axis.		circBFAR			laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR	"circBFAR is up-regulated in LSCC and promotes malignant phenotypes (proliferation, migration/invasion, and angiogenic tube formation) and xenograft tumor growth. It functions as a ceRNA by sponging miR-31-5p to upregulate COL5A1, and high circBFAR expression is associated with advanced stage and worse overall survival."	0.796
36550019	Journal of clinical laboratory analysis	2023	Hsa_circ_0092887 targeting miR-490-5p/UBE2T promotes paclitaxel resistance in non-small cell lung cancer.	hsa_circ_0092887	Circ_0092887	hsa_circ_DHTKD1	DHTKD1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0092887 is up-regulated in NSCLC, especially in PTX-resistant tissues and cell lines. It promotes paclitaxel resistance and malignant phenotypes by sponging miR-490-5p and releasing the downstream target UBE2T, thereby enhancing proliferation/migration and inhibiting apoptosis; its knockdown sensitizes cells to PTX and suppresses xenograft growth."	0.7785
36550514	Journal of orthopaedic surgery and research	2022	Circ_0083964 knockdown impedes rheumatoid arthritis progression via the miR-204-5p-dependent regulation of YY1.	hsa_circ_0083964	Circ_0083964 / circ-ASH2L	hsa_circ_ASH2L	ASH2L	rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"circ_0083964 is up-regulated in RA synovial tissues and RA-FLSs and promotes RA-FLS tumorlike behaviors (viability/proliferation, invasion/migration) and inflammatory cytokine release while suppressing apoptosis. Mechanistically, it sponges miR-204-5p to relieve repression of YY1, forming a circ_0083964/miR-204-5p/YY1 regulatory axis."	0.8119
36551768	Biomedicines	2022	CircDOCK1 Regulates miR-186/DNMT3A to Promote Osteosarcoma Progression.	hsa_circ_0020378	circDOCK1	hsa_circ_DOCK1	DOCK1	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circDOCK1 is up-regulated in osteosarcoma tissues and cell lines and promotes proliferation, migration/motility, invasion, and xenograft tumor growth. Mechanistically, circDOCK1 sponges miR-186 to relieve repression of DNMT3A, forming a circDOCK1/miR-186/DNMT3A ceRNA axis."	0.869
36551885	Biomedicines	2022	circRNAs May Be Involved in Dysfunction of Neutrophils of Type 2 Diabetic Mice through Regulation of Specific miRNAs.		mmu_circRNA_29357 / circRNA_29357			Type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RT-qPCR	mmu_circRNA_29357 is up-regulated in diabetic-derived bone-marrow neutrophils and is proposed to regulate (sponge) miR-129-2-3p based on predicted binding sites and inverse expression patterns. The study suggests it may contribute to inflammation-related neutrophil dysfunction in type 2 diabetic mice.	0.3684
36551885	Biomedicines	2022	circRNAs May Be Involved in Dysfunction of Neutrophils of Type 2 Diabetic Mice through Regulation of Specific miRNAs.		mmu_circRNA_22278 / circRNA_22278	mmu_circ_Dot1l	Dot1l	Type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	down-regulated	Microarray	"mmu_circRNA_22278 is down-regulated in diabetic-derived neutrophils by microarray and is predicted to target mmu-miR-92a-2-5p, which is increased in diabetic-derived neutrophils. The study proposes that this axis may relate to apoptosis regulation in the context of diabetic wound-associated neutrophil dysfunction."	0.3684
36562402	Cancer science	2023	Circular RNA circ0104103 inhibits colorectal cancer progression through interactions with HuR and miR-373-5p.	hsa_circ_0104103	circ0104103 / Circ_0104103	hsa_circ_LACTB	LACTB	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; ISH	"circ0104103 is down-regulated in colorectal cancer and functions as a tumor suppressor by inhibiting proliferation, migration/invasion, and metastasis. It increases LACTB expression through dual mechanisms: binding HuR to enhance LACTB mRNA stability and sponging miR-373-5p to relieve repression of LACTB."	0.8817
36567627	The Kaohsiung journal of medical sciences	2023	Circular RNA Sec61 subunit alpha isoform 1 by competitive absorption of microRNA-513a-5p mediates peroxisomal biogenesis factor 5 expression and promotes the malignant phenotype of non-small cell lung cancer.		circSEC61A1	hsa_circ_SEC61A1		non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circSEC61A1 is upregulated in NSCLC and functions as an oncogenic circRNA. It sponges miR-513a-5p to increase PEX5 expression, thereby promoting NSCLC cell malignant behaviors, glycolysis, EMT, and Wnt/beta-catenin pathway activation, and enhancing tumor growth and metastasis."	0.8491
36568366	Frontiers in genetics	2022	Analysis of infiltrated immune cells in left atriums from patients with atrial fibrillation and identification of circRNA biomarkers for postoperative atrial fibrillation.	hsa_circ_0006314				post-operative atrial fibrillation / POAF	MONDO:0004981	atrial fibrillation	unknown	Microarray	This circRNA was identified from ceRNA-network intersection and machine-learning feature selection as a potential plasma biomarker for predicting POAF. The proposed mechanism is a ceRNA link in which it interacts with has-miR-545-3p to mediate RELN expression.	0.1768
36568366	Frontiers in genetics	2022	Analysis of infiltrated immune cells in left atriums from patients with atrial fibrillation and identification of circRNA biomarkers for postoperative atrial fibrillation.	hsa_circ_0055387				post-operative atrial fibrillation / POAF	MONDO:0004981	atrial fibrillation	unknown	Microarray	"This circRNA was identified as a potential plasma biomarker for POAF by intersecting DEcircRNAs with ceRNA-network circRNAs and then applying multiple machine-learning models. It is proposed to act in a ceRNA manner by binding has-miR-27a-3p, thereby affecting LBH and RELN."	0.1768
36570001	PeerJ	2022	Knockdown of hsa_circ_0008922 inhibits the progression of glioma.	hsa_circ_0008922	circ_0008922 / hsa-circ-0008922	hsa_circ_MATR3	MATR3	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0008922 is up-regulated in glioma tissues and promotes malignant phenotypes (proliferation/colony formation, migration, invasion) while suppressing apoptosis in glioma cells. Mechanistically, it is predicted to function as a miRNA sponge forming a circRNA_miRNA_mRNA network involving multiple miRNAs (notably let-7 family members and miR-506-5p)."	0.7523
36573325	Thoracic cancer	2023	Circular RNA hsa_circ_0008003 promotes the progression of non-small-cell lung cancer by sponging miR-548I and regulating KPNA4 expression.	hsa_circ_0008003	circ_0008003	hsa_circ_LDB2	LDB2	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0008003 is up-regulated in NSCLC tissues and cell lines and its high expression is associated with poorer overall survival. Functionally, it promotes NSCLC malignant phenotypes and tumor growth by acting as a ceRNA to sponge miR-548I, thereby increasing KPNA4 expression."	0.8068
36575008	Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia	2023	Circ_0006220 Contributes to NSCLC Progression through miR-342-3p/GOT2 Axis.	hsa_circ_0006220	circ_0006220	hsa_circ_TADA2A	TADA2A	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"Circ_0006220 is up-regulated in NSCLC tissues, cell lines, and patient serum, and higher levels associate with advanced disease and worse survival. Functionally, it promotes NSCLC malignant phenotypes by acting as a ceRNA that sponges miR-342-3p and thereby increases GOT2 expression, enhancing proliferation, migration/invasion, and angiogenesis while suppressing apoptosis."	0.8498
36578555	"Open medicine (Warsaw, Poland)"	2022	circRNA DENND1B inhibits tumorigenicity of clear cell renal cell carcinoma via miR-122-5p/TIMP2 axis.	hsa_circ_0000168	circ_DENND1B / circRNA DENND1B	hsa_circ_DENND1B	DENND1B	clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	down-regulated	RT-qPCR; Microarray	"circ_DENND1B is down-regulated in ccRCC tissues/cells. Its overexpression suppresses proliferation, migration, invasion and EMT while promoting apoptosis, and inhibits xenograft tumor growth by sponging miR-122-5p to upregulate TIMP2."	0.7955
36585787	Briefings in bioinformatics	2023	Discovery of fusion circular RNAs in leukemia with KMT2A::AFF1 rearrangements by the new software CircFusion.		f-circK10-A2	hsa_circ_KMT2A-AFF1	KMT2A; AFF1	acute lymphoblastic leukemia / ALL	MONDO:0004967	acute lymphoblastic leukemia	unknown	RT-qPCR; RNA-seq	This study discovered and experimentally validated the KMT2A-AFF1 fusion circRNA f-circK10-A2 in the RS4;11 leukemia cell line using RNA-seq followed by RNase R-resistant divergent PCR and Sanger sequencing confirming both backsplice and fusion junctions.	0.4358
36585787	Briefings in bioinformatics	2023	Discovery of fusion circular RNAs in leukemia with KMT2A::AFF1 rearrangements by the new software CircFusion.		f-circA19-K7	hsa_circ_AFF1-KMT2A	AFF1; KMT2A	acute lymphoblastic leukemia / ALL	MONDO:0004967	acute lymphoblastic leukemia	unknown	RNA-seq	f-circA19-K7 is a recurrent AFF1::KMT2A-derived fusion circRNA detected by RNA-seq/CircFusion in two BCP-ALL patient samples (ALL1 and ALL5); no functional mechanism was tested in this paper.	0.1768
36585787	Briefings in bioinformatics	2023	Discovery of fusion circular RNAs in leukemia with KMT2A::AFF1 rearrangements by the new software CircFusion.		f-circK34-A2	hsa_circ_KMT2A-AFF1	KMT2A; AFF1	acute lymphoblastic leukemia / ALL	MONDO:0004967	acute lymphoblastic leukemia	unknown	RNA-seq	f-circK34-A2 is a recurrent KMT2A::AFF1-derived fusion circRNA detected by RNA-seq/CircFusion in two BCP-ALL patient samples (ALL3 and ALL4); no downstream targets or phenotypes were experimentally characterized in this work.	0.1768
36585787	Briefings in bioinformatics	2023	Discovery of fusion circular RNAs in leukemia with KMT2A::AFF1 rearrangements by the new software CircFusion.		f-circA7-K11	hsa_circ_AFF1-KMT2A	AFF1; KMT2A	acute lymphoblastic leukemia / ALL	MONDO:0004967	acute lymphoblastic leukemia	unknown	RNA-seq	f-circA7-K11 is an AFF1::KMT2A-derived fusion circRNA co-detected with f-circA19-K7 in one patient sample (ALL1) by RNA-seq/CircFusion; functional roles were not investigated.	0.1768
36585787	Briefings in bioinformatics	2023	Discovery of fusion circular RNAs in leukemia with KMT2A::AFF1 rearrangements by the new software CircFusion.		f-circK14-A3	hsa_circ_KMT2A-AFF1	KMT2A; AFF1	acute lymphoblastic leukemia / ALL	MONDO:0004967	acute lymphoblastic leukemia	unknown	RNA-seq	f-circK14-A3 is a KMT2A::AFF1-derived fusion circRNA detected in one patient sample (ALL5) by RNA-seq/CircFusion; functional characterization was not performed.	0.1768
36585787	Briefings in bioinformatics	2023	Discovery of fusion circular RNAs in leukemia with KMT2A::AFF1 rearrangements by the new software CircFusion.		f-circA19-K4	hsa_circ_AFF1-KMT2A	AFF1; KMT2A	acute lymphoblastic leukemia / ALL	MONDO:0004967	acute lymphoblastic leukemia	unknown	RNA-seq	f-circA19-K4 is an AFF1::KMT2A-derived fusion circRNA co-detected with f-circK34-A2 in one patient sample (ALL3) by RNA-seq/CircFusion; no mechanistic validation was reported.	0.1768
36585787	Briefings in bioinformatics	2023	Discovery of fusion circular RNAs in leukemia with KMT2A::AFF1 rearrangements by the new software CircFusion.		f-circA15-K7	hsa_circ_AFF1-KMT2A	AFF1; KMT2A	acute lymphoblastic leukemia / ALL	MONDO:0004967	acute lymphoblastic leukemia	unknown	RNA-seq	"f-circA15-K7 is an AFF1::KMT2A-derived fusion circRNA detected in patient sample ALL2, with abundance comparable to a linear fusion transcript; no mechanistic assays were reported."	0.1768
36585921	Aging	2022	Transcriptomic analysis of human ALS skeletal muscle reveals a disease-specific pattern of dysregulated circRNAs.	hsa_circ_0000119	circ_0000119	hsa_circ_MAN1A2	MAN1A2	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000119 is significantly elevated in ALS skeletal muscle by RT-qPCR and shows opposite-direction changes (decreased) in ALS spinal cord in both human and SOD1G93A mouse, suggesting it may be a disease-associated biomarker with tissue-dependent gradients; specific molecular function/mechanism was not determined."	0.6521
36585921	Aging	2022	Transcriptomic analysis of human ALS skeletal muscle reveals a disease-specific pattern of dysregulated circRNAs.	hsa_circ_0000567	circ_0000567	hsa_circ_SETD3	SETD3	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000567 is significantly elevated in ALS skeletal muscle (validated by RT-qPCR) and also increased in C9-ALS iPSC-derived motor neurons, but is decreased in ALS spinal cord/cortex, indicating tissue-dependent gradients; its function/mechanism was not defined in this study."	0.6521
36585921	Aging	2022	Transcriptomic analysis of human ALS skeletal muscle reveals a disease-specific pattern of dysregulated circRNAs.	hsa_circ_0007778		hsa_circ_SLC25A16	SLC25A16	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0007778 is elevated in ALS skeletal muscle (RT-qPCR validated) and also increased in C9-ALS iPSC-derived motor neurons; specific functional mechanism was not determined.	0.585
36585921	Aging	2022	Transcriptomic analysis of human ALS skeletal muscle reveals a disease-specific pattern of dysregulated circRNAs.	hsa_circ_0000099	circ_0000099	hsa_circ_AMY2B	AMY2B	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000099 is elevated in ALS skeletal muscle and increased in C9-ALS iPSC-derived motor neurons; it is not increased in ALS spinal cord and is decreased in frontal cortex, indicating tissue-specific gradients. No direct mechanism was established."	0.585
36585921	Aging	2022	Transcriptomic analysis of human ALS skeletal muscle reveals a disease-specific pattern of dysregulated circRNAs.	hsa_circ_0005171	circ_0005171	hsa_circ_TMEM38B	TMEM38B	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005171 is upregulated in ALS skeletal muscle and in C9-ALS iPSC-derived motor neurons, but reduced in ALS spinal cord; in SOD1G93A mouse muscle it increases with disease progression, supporting its potential as a progression-associated circRNA marker. Mechanism was not defined."	0.6521
36585921	Aging	2022	Transcriptomic analysis of human ALS skeletal muscle reveals a disease-specific pattern of dysregulated circRNAs.	hsa_circ_0000231	circ_0000231	hsa_circ_ARHGAP12	ARHGAP12	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000231 is upregulated in ALS skeletal muscle but reduced in ALS spinal cord and frontal cortex, suggesting a tissue-gradient pattern; no mechanism was established."	0.585
36585921	Aging	2022	Transcriptomic analysis of human ALS skeletal muscle reveals a disease-specific pattern of dysregulated circRNAs.	hsa_circ_0001451		hsa_circ_FBXW7	FBXW7	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0001451 is upregulated in ALS skeletal muscle (RT-qPCR validated). Its mechanism and functional impact were not determined in this study.	0.585
36585921	Aging	2022	Transcriptomic analysis of human ALS skeletal muscle reveals a disease-specific pattern of dysregulated circRNAs.	hsa_circ_0007099	circ_0007099	hsa_circ_ABHD2	ABHD2	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0007099 is upregulated in ALS skeletal muscle and increases together with its linear counterpart ABHD2 mRNA; it may show ALS-specific elevation compared with myopathy/neuropathy controls. No mechanism was described.	0.6521
36585921	Aging	2022	Transcriptomic analysis of human ALS skeletal muscle reveals a disease-specific pattern of dysregulated circRNAs.	hsa_circ_0047886	circ_0047886	hsa_circ_ZCCHC2	ZCCHC2	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0047886 is selectively downregulated in ALS skeletal muscle with unchanged linear counterpart ZCCHC2 mRNA, and is also reduced in ALS spinal cord. No mechanism was defined."	0.6521
36585921	Aging	2022	Transcriptomic analysis of human ALS skeletal muscle reveals a disease-specific pattern of dysregulated circRNAs.	hsa_circ_0141401	circ_0141041	hsa_circ_ALPK2	ALPK2	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0141401 is downregulated in ALS skeletal muscle and reduced in ALS spinal cord, but increased in ALS frontal cortex; its function/mechanism was not determined."	0.6521
36585921	Aging	2022	Transcriptomic analysis of human ALS skeletal muscle reveals a disease-specific pattern of dysregulated circRNAs.	hsa_circ_0117010		hsa_circ_NPHP1	NPHP1	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0117010 is downregulated in ALS skeletal muscle and also decreased in C9-ALS iPSC-derived motor neurons, while remaining unchanged in ALS spinal cord; no mechanism was described."	0.585
36585921	Aging	2022	Transcriptomic analysis of human ALS skeletal muscle reveals a disease-specific pattern of dysregulated circRNAs.	hsa_circ_0000033	circ_0000033	hsa_circ_CEP85	CEP85	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000033 is selectively downregulated in ALS skeletal muscle (CEP85 mRNA unchanged) and also reduced in ALS spinal cord; its mouse ortholog is altered already at the presymptomatic stage, suggesting early association with disease progression. Mechanism was not defined."	0.6521
36585921	Aging	2022	Transcriptomic analysis of human ALS skeletal muscle reveals a disease-specific pattern of dysregulated circRNAs.	hsa_circ_0000247		hsa_circ_MCU	MCU	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0000247 is selectively downregulated in ALS skeletal muscle while MCU mRNA is not changed; it is decreased in ALS spinal cord and increased in ALS frontal cortex (late stage). No mechanism was described.	0.585
36585921	Aging	2022	Transcriptomic analysis of human ALS skeletal muscle reveals a disease-specific pattern of dysregulated circRNAs.	hsa_circ_0009027		hsa_circ_ZNF362	ZNF362	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0009027 is selectively downregulated in ALS skeletal muscle (ZNF362 mRNA unchanged) and is also reduced in ALS spinal cord; mechanism was not defined.	0.585
36585921	Aging	2022	Transcriptomic analysis of human ALS skeletal muscle reveals a disease-specific pattern of dysregulated circRNAs.	hsa_circ_0056856	circ_0056856	hsa_circ_ITGB6	ITGB6	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0056856 is downregulated in ALS skeletal muscle together with decreased ITGB6 mRNA; it is decreased in C9-ALS motor neurons, unchanged in ALS spinal cord, and increased in ALS frontal cortex. No mechanism was established."	0.6521
36585921	Aging	2022	Transcriptomic analysis of human ALS skeletal muscle reveals a disease-specific pattern of dysregulated circRNAs.	hsa_circ_0001948		hsa_circ_CD99L2	CD99L2	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001948 is downregulated in ALS skeletal muscle together with its host-gene mRNA CD99L2, and is also reduced in ALS spinal cord; no mechanism was identified."	0.6521
36585921	Aging	2022	Transcriptomic analysis of human ALS skeletal muscle reveals a disease-specific pattern of dysregulated circRNAs.	hsa_circ_0000944	circ_0000944	hsa_circ_CCDC9	CCDC9	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000944 is downregulated in ALS skeletal muscle along with decreased host-gene mRNA CCDC9 and is reduced in ALS spinal cord, but increased in ALS frontal cortex; mechanism was not determined."	0.6521
36585921	Aging	2022	Transcriptomic analysis of human ALS skeletal muscle reveals a disease-specific pattern of dysregulated circRNAs.	hsa_circ_0006633	circ_0006633	hsa_circ_FGGY	FGGY	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0006633 is downregulated in ALS skeletal muscle while its linear counterpart FGGY mRNA is increased; it is also reduced in ALS spinal cord and in C9-ALS iPSC-derived motor neurons. No mechanism was established.	0.585
36586189	Translational oncology	2023	An evaluation of gastric adenocarcinoma-associated CircRNAs based on microarray meta-analysis and ceRNA networks.	hsa_circ_0006827	hsa_circRNA_100438			gastric adenocarcinoma / GA	MONDO:0005036	gastric adenocarcinoma	up-regulated	Microarray	hsa_circ_0006827 was identified as an up-regulated circRNA in gastric adenocarcinoma based on a microarray meta-analysis; no downstream miRNA/mRNA mechanism was reported specifically for this circRNA.	0.1768
36590290	Frontiers in neuroscience	2022	Inhibition by rno-circRNA-013017 of the apoptosis of motor neurons in anterior horn and descending axonal degeneration in rats after traumatic spinal cord injury.		rno-circRNA-013017			spinal cord injury / SCI	MONDO:0043797	spinal cord injury	down-regulated	RT-qPCR; Microarray	"In a rat contusion SCI model, rno-circRNA-013017 is downregulated after injury, and its AAV-mediated overexpression reduces motor neuron apoptosis, protects descending axons, and improves locomotor recovery. Mechanistically, it is supported as a regulator of the rno-miR-16-5p/bcl-2 axis and apoptosis-related proteins."	0.5979
36590309	Journal of oncology	2022	circPOLR1C Promotes the Development of Esophageal Cancer by Adsorbing miR-361-3p and Regulating Cancer Cell Apoptosis and Metastasis.	hsa_circ_0076535	circPOLR1C	hsa_circ_POLR1C	POLR1C	esophageal cancer / EC	MONDO:0007576	esophageal cancer	up-regulated	RT-qPCR	"circPOLR1C is up-regulated in esophageal cancer tissues/cells and promotes malignant phenotypes (proliferation, migration/invasion, xenograft growth and lung metastasis) while inhibiting apoptosis. Mechanistically, it mainly localizes to the cytoplasm and functions as a sponge for miR-361-3p, thereby modulating apoptosis- and EMT-related targets such as DUSP2, XIAP and BCL2."	0.8635
36593867	Journal of oncology	2022	Hsa_circ_0000520 Promotes Non-Small Cell Lung Cancer Progression through the miR-1258/AKT3 Axis.	hsa_circ_0000520	circRNA_0000520 / circ_0000520			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0000520 is upregulated in NSCLC and promotes malignant phenotypes (proliferation, migration, invasion) and tumor growth. Mechanistically, it functions as a ceRNA by sponging miR-1258 to increase AKT3 expression, and higher circ_0000520 is associated with advanced TNM stage, lymph node metastasis, and poorer overall survival."	0.7486
36594050	Canadian journal of gastroenterology & hepatology	2022	Hsa_circ_0006988 Promotes Sorafenib Resistance of Hepatocellular Carcinoma by Modulating IGF1 Using miR-15a-5p.	hsa_circ_0006988				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"In sorafenib-resistant HCC, hsa_circ_0006988 is up-regulated and promotes sorafenib resistance. Mechanistically, it sponges miR-15a-5p to relieve repression on IGF1, increasing IGF1 levels and reducing sorafenib toxicity."	0.7842
36597139	Clinical and translational medicine	2023	Exosome-derived circTFDP2 promotes prostate cancer progression by preventing PARP1 from caspase-3-dependent cleavage.	hsa_circ_0008304	circTFDP2	hsa_circ_TFDP2	TFDP2	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	circTFDP2 (hsa_circ_0008304) is upregulated in prostate cancer and correlates with more aggressive clinicopathologic features. It promotes PCa proliferation and metastasis and reduces apoptosis and DNA damage by binding PARP1 and preventing caspase-3-dependent PARP1 cleavage. circTFDP2 is enriched in exosomes from PCa cells and exosome-delivered circTFDP2 further enhances PCa progression.	0.8446
36597856	Journal of clinical laboratory analysis	2023	Hsa_circ_0001944 enhanced GSPT1 expression via sponging miR-498 to promote proliferation and invasion of gastric cancer.	hsa_circ_0001944	circFIRRE	hsa_circ_FIRRE	FIRRE	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001944 (circFIRRE) is up-regulated in gastric cancer and functions as an oncogenic circRNA. It mainly localizes to the cytoplasm and promotes proliferation, invasion, migration, and in vivo tumor growth by sponging miR-498 to increase GSPT1 expression, forming the hsa_circ_0001944/miR-498/GSPT1 axis."	0.8792
36597862	Journal of clinical laboratory analysis	2023	Silencing circUSP48 suppresses osteosarcoma progression by regulating the miR-335/ smad nuclear interacting protein 1 pathway.	hsa_circ_0000028	circUSP48	hsa_circ_SNIP1		osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"circUSP48 is up-regulated in osteosarcoma tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation, migration and invasion by sponging miR-335 and thereby upregulating SNIP1; circUSP48 knockdown suppresses xenograft tumor growth."	0.8635
36597889	Journal of clinical laboratory analysis	2023	"Comprehensive analysis of aberrantly expressed circRNAs, mRNAs and lncRNAs in patients with nasopharyngeal carcinoma."	hsa_circ_0067562				nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	Microarray	hsa-circ-0067562 was identified by microarray as the most upregulated circRNA in NPC tissues versus chronic nasopharyngitis tissues; no specific downstream mechanism or function was experimentally validated for this circRNA in the study.	0.1768
36597889	Journal of clinical laboratory analysis	2023	"Comprehensive analysis of aberrantly expressed circRNAs, mRNAs and lncRNAs in patients with nasopharyngeal carcinoma."	hsa_circ_0078837				nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	down-regulated	Microarray	hsa_circ_0078837 was identified by microarray as the most downregulated circRNA in NPC tissues versus chronic nasopharyngitis tissues; no specific downstream mechanism or function was experimentally validated for this circRNA in the study.	0.1768
36597889	Journal of clinical laboratory analysis	2023	"Comprehensive analysis of aberrantly expressed circRNAs, mRNAs and lncRNAs in patients with nasopharyngeal carcinoma."	hsa_circ_0002354		hsa_circ_SPATS2L	SPATS2L	nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0002354 (host gene SPATS2L) was validated by RT-qPCR to be up-regulated in NPC cell lines compared with NP69, and its back-splice junction PCR product was confirmed by Sanger sequencing; no specific mechanistic axis was established."	0.4761
36597889	Journal of clinical laboratory analysis	2023	"Comprehensive analysis of aberrantly expressed circRNAs, mRNAs and lncRNAs in patients with nasopharyngeal carcinoma."	hsa_circ_0055854		hsa_circ_AFF3	AFF3	nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0055854 (host gene AFF3, per Table 3) was validated by RT-qPCR to be down-regulated in NPC cell lines compared with NP69, and the circRNA junction PCR product was confirmed by Sanger sequencing; no specific mechanistic axis was established."	0.4761
36604982	Clinical and translational medicine	2023	CircZSWIM6 mediates dysregulation of ECM and energy homeostasis in ageing chondrocytes through RPS14 post-translational modification.	hsa_circ_0006381	CircZSWIM6	hsa_circ_ZSWIM6	ZSWIM6	osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; ISH; RNA-seq	"CircZSWIM6 (hsa_circ_0006381) is up-regulated in ageing human chondrocytes and promotes senescence and ECM catabolism, aggravating OA phenotypes. It binds RPS14 and blocks STUB1-mediated ubiquitination at RPS14 K125 to stabilize RPS14, leading to reduced PCK1 and suppression of AMPK signaling and energy homeostasis (ATP/OCR)."	0.7909
36605481	Journal of Cancer	2023	Hypoxia-induced miR-653 enhances colorectal cancer progression by targeting circSETD3/KLF6 axis.	hsa_circ_0000567	circSETD3	hsa_circ_SETD3	SETD3	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"In CRC cells, circSETD3 (hsa_circ_0000567) is down-regulated and acts as a miRNA sponge for miR-653, thereby relieving miR-653-mediated suppression of KLF6. circSETD3 overexpression counteracts miR-653-driven proliferation, migration and invasion and supports apoptosis, suggesting a tumor-suppressive role via the circSETD3/miR-653/KLF6 axis."	0.6952
36608542	Translational oncology	2023	Circ_0101692 knockdown retards the development of clear cell renal cell carcinoma through miR-384/FN1 pathway.	hsa_circ_0101692	Circular RNA_0101692 / circ_0101692 	hsa_circ_EGLN3	EGLN3	clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR	"circ_0101692 is up-regulated in ccRCC tissues and cell lines and is mainly cytoplasmic. Functional assays show that circ_0101692 promotes ccRCC proliferation and migration and inhibits apoptosis, partly by sponging miR-384 to upregulate FN1; circ_0101692 knockdown also suppresses xenograft tumor growth."	0.6996
36609391	Cell death & disease	2023	Hsa_circ_0021727 (circ-CD44) promotes ESCC progression by targeting miR-23b-5p to activate the TAB1/NFkappaB pathway.	hsa_circ_0021727	circ-CD44 / circ_0021727	hsa_circ_CD44	CD44	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"hsa_circ_0021727 (circ-CD44) is up-regulated in ESCC and promotes tumor cell proliferation, invasion, migration, and metastasis. Mechanistically, it sponges miR-23b-5p to increase TAB1 and activate NFkappaB signaling, and high hsa_circ_0021727 expression predicts worse survival."	0.8846
36611218	Biomarker research	2023	Circular RNA circEMB promotes osteosarcoma progression and metastasis by sponging miR-3184-5p and regulating EGFR expression.	hsa_circ_0001481	circEMB	hsa_circ_EMB	EMB	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; RNA-seq	"circEMB is up-regulated in osteosarcoma tissues/cells and promotes proliferation, invasion/migration, metastasis, and MTX resistance. It mainly functions as a cytoplasmic ceRNA by sponging miR-3184-5p in an Ago2-associated complex, thereby increasing EGFR expression and impacting Notch signaling. High circEMB expression correlates with metastasis and poor prognosis."	0.8942
36612069	Cancers	2022	Hsa_circ_0015278 Regulates FLT3-ITD AML Progression via Ferroptosis-Related Genes.	hsa_circ_0015278	hsa_circ_0015278 / 0015278			acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; Microarray	"This study identifies hsa_circ_0015278 as up-regulated in FLT3-ITD AML and proposes it promotes disease progression via a ceRNA network that sponges multiple miRNAs to modulate ferroptosis-related hub genes (notably MAPK3 and CD44). The axis is suggested to have diagnostic/prognostic relevance, though circRNA-level prognostic testing in patient cohorts was not directly shown."	0.437
36612069	Cancers	2022	Hsa_circ_0015278 Regulates FLT3-ITD AML Progression via Ferroptosis-Related Genes.	hsa_circ_0049365				acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; Microarray	"hsa_circ_0049365 was experimentally validated to be up-regulated in AML cell lines (HL-60 and MOLM-13) versus BMSCs, with higher expression in FLT3-ITD+ MOLM-13 than FLT3-ITD_ HL-60. No specific downstream targets or mechanisms were further characterized in this paper."	0.437
36612069	Cancers	2022	Hsa_circ_0015278 Regulates FLT3-ITD AML Progression via Ferroptosis-Related Genes.	hsa_circ_0003162				acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; Microarray	"hsa_circ_0003162 was validated by RT-qPCR and Sanger sequencing as a circular RNA with elevated expression in AML cell lines (HL-60 and MOLM-13) versus BMSCs, and higher in FLT3-ITD+ MOLM-13 than HL-60. The paper does not further define its downstream regulatory axis or function."	0.437
36612069	Cancers	2022	Hsa_circ_0015278 Regulates FLT3-ITD AML Progression via Ferroptosis-Related Genes.	hsa_circ_0011536				acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; Microarray	hsa_circ_0011536 was validated as up-regulated in AML cell lines relative to BMSCs and showed higher expression in FLT3-ITD+ MOLM-13 compared with HL-60. No mechanistic axis or functional assays were presented for this circRNA in the study.	0.437
36612120	Cancers	2022	Tumor Cell-Derived Exosomal circ-PRKCI Promotes Proliferation of Renal Cell Carcinoma via Regulating miR-545-3p/CCND1 Axis.	hsa_circ_0067934	circ-PRKCI	hsa_circ_PRKCI	PRKCI	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR	"circ-PRKCI (hsa_circ_0067934) is upregulated in RCC tissues and serum exosomes and can be transferred from highly malignant Caki-1 cells to less malignant RCC cells via exosomes. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-545-3p to increase CCND1, thereby promoting RCC proliferation; it also enhances migration/invasion and inhibits apoptosis in RCC cells in exosome/circ-PRKCI gain-of-function settings."	0.7302
36613512	International journal of molecular sciences	2022	AML1-ETO-Related Fusion Circular RNAs Contribute to the Proliferation of Leukemia Cells.		F-CircAE2	hsa_circ_RUNX1-RUNX1T1		acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"F-CircAE2 is a fusion-derived circRNA from AML1-ETO detected in AML1-ETO-positive AML cell lines and patient BMMNCs. It promotes proliferation/colony formation and supports leukemia cell maintenance by binding ENO1 and enhancing glycolytic enzyme expression and lactate production, indicating a pro-glycolysis, pro-growth role."	0.8055
36613512	International journal of molecular sciences	2022	AML1-ETO-Related Fusion Circular RNAs Contribute to the Proliferation of Leukemia Cells.		F-CircAE3	hsa_circ_RUNX1-RUNX1T1		acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	unknown	RT-qPCR	"F-CircAE3 is an AML1-ETO fusion-derived circRNA whose combined depletion with F-CircAE2 reduces Kasumi-1 growth, induces G1 arrest, and is associated with decreased glycolysis gene-set expression, indicating it contributes to leukemia cell maintenance mainly supported by dual-knockdown evidence."	0.5803
36617466	BMB reports	2023	circRNA circSnx12 confers Cisplatin chemoresistance to ovarian cancer by inhibiting ferroptosis through a miR-194-5p/SLC7A11 axis.		circSnx12	hsa_circ_Snx12	Snx12	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; ISH	"circSnx12 is up-regulated in cisplatin-resistant ovarian cancer tissues and DDP-resistant cell lines. It promotes cisplatin chemoresistance by sponging miR-194-5p to increase SLC7A11 expression, thereby inhibiting ferroptosis; circSnx12 knockdown restores ferroptosis and sensitizes resistant cells to cisplatin in vitro and in vivo."	0.6601
36618263	Molecular therapy. Nucleic acids	2023	CDR1as regulates alpha-synuclein-mediated ischemic brain damage by controlling miR-7 availability.		CDR1as / ciRS-7	mmu_circ_CDR1		ischemic stroke / IS	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR	"In mouse transient MCAO, CDR1as is down-regulated in peri-infarct cortex. Reconstitution/overexpression of CDR1as preserves miR-7 availability (via Ago2-associated binding), suppresses alpha-synuclein induction, and reduces secondary ischemic brain injury with improved motor recovery, partly by limiting apoptosis, autophagy, mitochondrial fragmentation, and inflammation."	0.6916
36620570	Frontiers in oncology	2022	Detecting plasma hsa_circ_0061276 in patients with gastric cancer by reverse transcription-digital polymerase chain reaction.	hsa_circ_0061276		hsa_circ_NRIP1	NRIP1	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"In gastric cancer, hsa_circ_0061276 is decreased in plasma and gastric cancer cell lines/tissues and shows diagnostic potential by RT-ddPCR with ROC performance for early and advanced disease. Functionally, it acts as a tumor suppressor by inhibiting proliferation and migration and inducing G0/G1 arrest. Mechanistically, it functions mainly in the cytoplasm as a miRNA sponge, with validated binding to hsa-miR-7705."	0.7941
36624091	Cell death & disease	2023	Circular RNA circPOFUT1 enhances malignant phenotypes and autophagy-associated chemoresistance via sequestrating miR-488-3p to activate the PLAG1-ATG12 axis in gastric cancer.	hsa_circ_0059773	circPOFUT1	hsa_circ_POFUT1	POFUT1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; ISH	"circPOFUT1 is upregulated in gastric cancer and is associated with worse patient survival. It promotes proliferation, migration, invasion, and autophagy-associated cisplatin resistance by sponging miR-488-3p to activate the PLAG1-driven ATG12 program, enhancing tumor growth in xenografts."	0.8772
36625877	Inflammation research : official journal of the European Histamine Research Society ... [et al.]	2023	circFLNA promotes intestinal injury during abdominal sepsis through Fas-mediated apoptosis pathway by sponging miR-766-3p.	hsa_circ_0092012	circFLNA	hsa_circ_FLNA	FLNA	sepsis	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR; Microarray	"circFLNA is up-regulated in intestinal epithelium during abdominal sepsis and in LPS-treated HIEC-6 cells. It localizes mainly in the cytoplasm and promotes intestinal epithelial apoptosis and inflammation by sponging miR-766-3p, thereby increasing Fas expression and activating the Fas-mediated extrinsic apoptosis pathway; circFLNA knockdown alleviates intestinal injury in the CLP mouse sepsis model."	0.8684
36628612	Thoracic cancer	2023	"Circular RNA, circular RARS, promotes aerobic glycolysis of non-small-cell lung cancer by binding with LDHA."	hsa_circ_0001551	circRARS / circular RARS	hsa_circ_RARS	RARS	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"circRARS (hsa_circ_0001551), derived from RARS, is up-regulated in NSCLC/LUAD and associates with aggressive clinicopathologic features and poorer overall survival. Functionally, circRARS promotes proliferation, invasion, migration, and aerobic glycolysis, at least partly by binding LDHA and enhancing LDHA activity while upregulating LDHA expression at the transcriptional level."	0.8369
36632453	International journal of biological sciences	2023	Apelin promotes osteosarcoma metastasis by upregulating PLOD2 expression via the Hippo signaling pathway and hsa_circ_0000004/miR-1303 axis.	hsa_circ_0000004	circ_0000004			osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"In osteosarcoma, hsa_circ_0000004 is upregulated and promotes cell migration/metastatic behavior by sponging miR-1303, thereby increasing PLOD2 expression. It functions as part of an APLN-driven ceRNA axis (hsa_circ_0000004/miR-1303/PLOD2) linked to Hippo pathway activation."	0.6672
36632741	Cancer science	2023	Circular RNA ARHGAP5 inhibits cisplatin resistance in cervical squamous cell carcinoma by interacting with AUF1.	hsa_circ_0031584	circARHGAP5 / Circular RNA ARHGAP5 / circARHGAP5_1 / circARHGAP5_2	hsa_circ_ARHGAP5	ARHGAP5	cervical squamous cell carcinoma / CSCC	MONDO:0006143	cervical squamous cell carcinoma	down-regulated	RT-qPCR; RNA-seq	"circARHGAP5 is down-regulated in cisplatin-resistant CSCC tissues and acts as a tumor-suppressive circRNA that increases cisplatin sensitivity. It binds AUF1 in the cytoplasm, limiting AUF1-mediated BIM mRNA decay, thereby elevating BIM and promoting cisplatin-induced apoptosis while reducing proliferation and drug resistance."	0.7806
36635258	Cell death discovery	2023	Circular RNA circTRPS1-2 inhibits the proliferation and migration of esophageal squamous cell carcinoma by reducing the production of ribosomes.	hsa_circ_0085362	circTRPS1-2	hsa_circ_TRPS1	TRPS1	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	RT-qPCR; RNA-seq	"circTRPS1-2 (hsa_circ_0085362), derived from TRPS1, is down-regulated in ESCC tissues and cell lines. It suppresses ESCC cell proliferation, migration, tumor growth and metastasis, likely by binding multiple ribosomal proteins (RPS4X/RPS8/RPS24/RPL7/RPL11) and reducing ribosome biogenesis/production; higher expression is associated with better overall survival."	0.8671
36635261	Cell death & disease	2023	The U2AF65/circNCAPG/RREB1 feedback loop promotes malignant phenotypes of glioma stem cells through activating the TGF-beta pathway.	hsa_circ_0069280	circNCAPG	hsa_circ_NCAPG	NCAPG	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; Microarray	"circNCAPG (hsa_circ_0069280), derived from NCAPG, is up-regulated in glioma and promotes glioma stem cell proliferation, invasion and self-renewal. Mechanistically, U2AF65 binds and stabilizes circNCAPG, while circNCAPG binds/stabilizes RREB1 and promotes its nuclear translocation to activate TGF-beta/SMAD signaling; RREB1 in turn transcriptionally upregulates U2AF65, forming a positive feedback loop. High circNCAPG expression is associated with poor prognosis and shows diagnostic value in glioma patients."	0.9
36635270	Cell death & disease	2023	CircRNA MBOAT2 promotes intrahepatic cholangiocarcinoma progression and lipid metabolism reprogramming by stabilizing PTBP1 to facilitate FASN mRNA cytoplasmic export.	hsa_circ_0007334	circMBOAT2	hsa_circ_MBOAT2	MBOAT2	intrahepatic cholangiocarcinoma / ICC	MONDO:0003210	intrahepatic cholangiocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circMBOAT2 (hsa_circ_0007334) is upregulated in intrahepatic cholangiocarcinoma and promotes tumor growth and metastatic phenotypes. It acts mainly by binding and stabilizing PTBP1 (reducing PTBP1 ubiquitin/proteasome degradation), thereby enhancing PTBP1-mediated cytoplasmic export of FASN mRNA and increasing FASN translation. This reprograms lipid metabolism toward unsaturated fatty acids and helps maintain redox homeostasis (lower ROS/lipid peroxidation), contributing to ICC progression and suggesting a potential therapeutic target."	0.8661
36635757	Journal of translational medicine	2023	CircNDC80 promotes glioblastoma multiforme tumorigenesis via the miR-139-5p/ECE1 pathway.	hsa_circ_0046706	CircNDC80 / cNDC80	hsa_circ_NDC80	NDC80	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR	"circNDC80 (hsa_circ_0046706) is up-regulated in glioma/GBM tissues and promotes GBM cell proliferation, migration, invasion and glioma stem cell maintenance. Mechanistically, it acts as a ceRNA by sponging miR-139-5p to increase ECE1 expression, thereby driving tumor growth in vitro and in an intracranial xenograft model."	0.8832
36636050	Journal of gastrointestinal oncology	2022	The hsa_circ_0007396-miR-767-3p-CHD4 axis is involved in the progression and carcinogenesis of gastric cancer.	hsa_circ_0007396	hsa_circRNA_102476			gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	Microarray	This study identified hsa_circ_0007396 as a down-regulated circRNA in gastric cancer using GEO datasets. A predicted regulatory axis hsa_circ_0007396/miR-767-3p/CHD4 was proposed as being associated with GC proliferation and carcinogenesis based on bioinformatics analyses.	0.1768
36639711	Cell death & disease	2023	CircIFNGR2 enhances proliferation and migration of CRC and induces cetuximab resistance by indirectly targeting KRAS via sponging to MiR-30b.		circIFNGR2 / hsa_circ_001185 	hsa_circ_IFNGR2	INFGR2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circIFNGR2 is up-regulated in colorectal cancer tissues and promotes CRC cell proliferation, invasion/migration, metastasis, and in vivo tumor growth. Mechanistically, it localizes to the cytoplasm and sponges miR-30b, thereby relieving miR-30b-mediated repression of KRAS and enhancing downstream ERK/AKT signaling, which contributes to cetuximab resistance (especially in WT-KRAS CRC). High circIFNGR2 expression is associated with advanced stage and poor prognosis."	0.849
36642417	Bone & joint research	2023	CircStrn3 targeting microRNA-9-5p is involved in the regulation of cartilage degeneration and subchondral bone remodelling in osteoarthritis.		circStrn3 / cicrStrn3	hsa_circ_Strn3	strn3	osteoarthritis / OA	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR; ISH; RNA-seq	"circStrn3 is down-regulated in osteoarthritis cartilage and chondrocytes in humans and mice. It primarily localizes to the cytoplasm and acts as a ceRNA to sponge miR-9-5p, thereby modulating KLF5 and chondrocyte extracellular matrix/matrix metabolism under mechanical stress; its reduction is suggested to be protective in mechanical instability-induced OA."	0.7924
36642417	Bone & joint research	2023	CircStrn3 targeting microRNA-9-5p is involved in the regulation of cartilage degeneration and subchondral bone remodelling in osteoarthritis.		circStrn3 / cicrStrn3	mmu_circ_Strn3	strn3	osteoarthritis / OA	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR; ISH; RNA-seq	"circStrn3 is down-regulated in osteoarthritis cartilage and chondrocytes in humans and mice. It primarily localizes to the cytoplasm and acts as a ceRNA to sponge miR-9-5p, thereby modulating KLF5 and chondrocyte extracellular matrix/matrix metabolism under mechanical stress; its reduction is suggested to be protective in mechanical instability-induced OA."	0.7924
36643221	Journal of dental sciences	2023	Circ_0004491 stimulates guanine nucleotide-binding protein alpha subunit to inhibit the malignant progression of oral squamous cell carcinoma by sponging miR-2278.	hsa_circ_0004491	circORC4 / circ_0004491	hsa_circ_ORC4	ORC4	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR	"circ_0004491 (circORC4; hsa_circ_0004491) is down-regulated in OSCC tissues and cell lines and functions as a tumor suppressor. It sponges miR-2278 to relieve repression of GNAS, thereby inhibiting proliferation/migration/invasion and promoting apoptosis, including reduced xenograft tumor growth."	0.8298
36643232	Journal of dental sciences	2023	Circ_0138960 knockdown alleviates lipopolysaccharide-induced inflammatory response and injury in human dental pulp cells by targeting miR-545-5p/MYD88 axis in pulpitis.	hsa_circ_0138960	circ_0138960			pulpitis	MONDO:0006937	pulpitis	up-regulated	RT-qPCR	"In pulpitis (patient pulp tissues) and an LPS-induced hDPC model, circ_0138960 is up-regulated and aggravates inflammatory injury. Mechanistically, circ_0138960 sponges miR-545-5p to increase MYD88 and promote NF-kappaB signaling; circ_0138960 knockdown alleviates inflammation, apoptosis, and oxidative stress while restoring proliferation."	0.7591
36643256	Journal of dental sciences	2023	Anti-apoptosis and anti-inflammation activity of circ_0097010 downregulation in lipopolysaccharide-stimulated periodontal ligament cells by miR-769-5p/Kr¨¹ppel like factor 6 axis.	hsa_circ_0097010	circ_0097010	hsa_circ_SLC5A8	SLC5A8	periodontitis	MONDO:0005076	periodontitis	up-regulated	RT-qPCR	"circ_0097010 is upregulated in periodontitis gingival tissues and in LPS-stimulated hPDLCs. Silencing circ_0097010 reduces LPS-induced apoptosis and inflammatory/oxidative injury by acting as a sponge for miR-769-5p, thereby decreasing KLF6 expression (circ_0097010/miR-769-5p/KLF6 ceRNA axis)."	0.779
36643258	Journal of dental sciences	2023	Hsa_circ_0005050 regulated the progression of oral squamous cell carcinoma via miR-487a-3p/CHSY1 axis.	hsa_circ_0005050	circ_0005050	hsa_circ_XPO1	XPO1	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circ_0005050 is up-regulated in OSCC tissues and cell lines and promotes malignant phenotypes (proliferation and migration) while inhibiting apoptosis. Mechanistically, it sponges miR-487a-3p to increase CHSY1 expression, and its knockdown suppresses tumor growth in xenograft models."	0.7589
36643863	International journal of nanomedicine	2023	Exosome-Delivered circSTAU2 Inhibits the Progression of Gastric Cancer by Targeting the miR-589/CAPZA1 Axis.	hsa_circ_0001811	circSTAU2	hsa_circ_STAU2	STAU2	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"circSTAU2 (hsa_circ_0001811) is down-regulated in gastric cancer and functions as a tumor suppressor. It is packaged into exosomes and, after uptake by recipient cells, sponges miR-589 to de-repress CAPZA1, thereby inhibiting proliferation, migration/invasion and promoting apoptosis; MBNL1 promotes circSTAU2 biogenesis/expression upstream."	0.8354
36644969	Journal of clinical laboratory analysis	2023	Serum circular RNA hsa_circ_0000702 as a novel biomarker for diagnosis of gastric cancer.	hsa_circ_0000702		hsa_circ_CHD9	CHD9	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"hsa_circ_0000702 is significantly down-regulated in gastric cancer serum, tissues, and GC cell lines and shows diagnostic utility (AUC 0.745), further improved when combined with CEA and CA19-9. It is enriched slightly in the cytoplasm and is proposed to act via a ceRNA mechanism with predicted miRNAs (hsa-miR-708-5p and hsa-miR-28-5p), supporting its potential as a biomarker for diagnosis and postoperative dynamic monitoring."	0.6841
36644997	Journal of clinical laboratory analysis	2023	"Circular RNA SPI1 expression before and after induction therapy and its correlation with clinical features, treatment response, and survival of acute myeloid leukemia patients."	hsa_circ_0000303	circ_SPI1	hsa_circ_SPI1	SPI1	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	circ-SPI1 (hsa_circ_0000303) is up-regulated in AML bone marrow compared with controls. Its level decreases after induction therapy; low post-therapy expression and a ¡Ý30% decline during treatment are associated with complete remission and independently predict longer EFS and OS.	0.5121
36650519	Cell division	2023	Circular RNA hsa_circ_0075323 promotes glioblastoma cells proliferation and invasion via regulation of autophagy.	hsa_circ_0075323	CircSQSTM1 / circ_007532	hsa_circ_SQSTM1	SQSTM1	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR	"hsa_circ_0075323 (CircSQSTM1) is up-regulated in glioblastoma cell lines and mainly localized in the cytoplasm. Gain- and loss-of-function experiments show it promotes proliferation and invasive/migratory behaviors. Mechanistically, it promotes p62-associated autophagy activity (with p62 increased and LC3B decreased after circRNA depletion), supporting a tumor-promoting role in GBM."	0.4636
36655871	The Kaohsiung journal of medical sciences	2023	RNA sequencing and bioinformatics analysis of circular RNAs in asphyxial newborns with acute kidney injury.	hsa_circ_0008898		hsa_circ_OAT	OAT	acute kidney injury / AKI	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0008898 is significantly up-regulated in peripheral blood from asphyxia-induced neonatal AKI patients versus controls, supported by RNA-seq and RT-qPCR validation. No AKI-specific mechanism or targets were experimentally established in this study."	0.5135
36655871	The Kaohsiung journal of medical sciences	2023	RNA sequencing and bioinformatics analysis of circular RNAs in asphyxial newborns with acute kidney injury.	hsa_circ_0005519		hsa_circ_SNX13	SNX13	acute kidney injury / AKI	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005519 is significantly up-regulated in peripheral blood from asphyxia-induced neonatal AKI patients versus controls and was validated by RT-qPCR. The authors suggest it may be involved in AKI-related inflammatory responses, with a putative link to hsa-let-7a-5p and IL-13/IL-6 based on prior evidence."	0.5135
36655871	The Kaohsiung journal of medical sciences	2023	RNA sequencing and bioinformatics analysis of circular RNAs in asphyxial newborns with acute kidney injury.	hsa_circ_0132279		hsa_circ_SLC17A5	SLC17A5	acute kidney injury / AKI	MONDO:0002492	acute kidney injury	down-regulated	RNA-seq	hsa_circ_0132279 is reported as significantly down-regulated in peripheral blood of asphyxia-induced neonatal AKI patients compared with controls. No mechanistic or clinical significance experiments specific to this circRNA were provided.	0.329
36655871	The Kaohsiung journal of medical sciences	2023	RNA sequencing and bioinformatics analysis of circular RNAs in asphyxial newborns with acute kidney injury.	hsa_circ_0112327		hsa_circ_NUP133	NUP133	acute kidney injury / AKI	MONDO:0002492	acute kidney injury	down-regulated	RNA-seq	hsa_circ_0112327 is reported as down-regulated in peripheral blood of asphyxia-induced neonatal AKI patients compared with controls. The study does not provide specific downstream targets or functional experiments for this circRNA.	0.329
36655871	The Kaohsiung journal of medical sciences	2023	RNA sequencing and bioinformatics analysis of circular RNAs in asphyxial newborns with acute kidney injury.	hsa_circ_0017647		hsa_circ_SFMBT2	SFMBT2	acute kidney injury / AKI	MONDO:0002492	acute kidney injury	down-regulated	RNA-seq	hsa_circ_0017647 is reported as significantly down-regulated in peripheral blood of asphyxia-induced neonatal AKI patients compared with controls. The study provides no circRNA-specific functional assays or validated interaction network for this circRNA.	0.329
36658304	Oncogene	2023	CircVPRBP inhibits nodal metastasis of cervical cancer by impeding RACK1 O-GlcNAcylation and stability.	hsa_circ_0065898	circVPRBP	hsa_circ_VPRBP	VPRBP	cervical cancer / CC	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR; ISH	"circVPRBP (hsa_circ_0065898) is down-regulated in cervical cancer, especially in lymph node metastatic cases, and low expression correlates with worse survival. Functionally, circVPRBP suppresses invasion, lymphangiogenesis, tumor growth and lymph node metastasis by binding RACK1 and blocking its S122 O-GlcNAcylation, promoting ubiquitin-proteasome degradation of RACK1 and reducing Galectin-1/pAKT/pFAK signaling."	0.8905
36659830	Journal of gynecologic oncology	2023	CircSMAD2 accelerates endometrial cancer cell proliferation and metastasis by regulating the miR-1277-5p/MFGE8 axis.		CircSMAD2	hsa_circ_SMAD2	SMAD2	endometrial cancer / EC	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR	"circSMAD2 is up-regulated in endometrial cancer tissues and cell lines and acts as an oncogenic circRNA. It promotes proliferation, migration/invasion, angiogenesis and in vivo tumor growth by sponging miR-1277-5p, thereby increasing MFGE8 expression."	0.849
36660942	Molecular medicine reports	2023	Differential methylation of circRNA m6A in an APP/PS1 Alzheimer's disease mouse model.		chr16:85056324-85120697- / circAPP	mmu_circ_APP	APP	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	unknown	RT-qPCR; RNA-seq	"This APP-derived circRNA shows altered m6A methylation in APP/PS1 AD mouse brain versus controls, supported by circRNA m6A-seq and MeRIP-RT-qPCR. The study suggests it may relate to AD pathogenesis, and highlights it for future evaluation regarding Abeta production."	0.5415
36660942	Molecular medicine reports	2023	Differential methylation of circRNA m6A in an APP/PS1 Alzheimer's disease mouse model.		chr16:85013627-85030365+	mmu_circ_APP	APP	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	unknown	RT-qPCR; RNA-seq	"This APP-derived circRNA is among the eight circRNAs with significantly altered m6A methylation in APP/PS1 AD mouse brain compared with controls, validated by MeRIP-RT-qPCR after circRNA m6A-seq screening."	0.5415
36660942	Molecular medicine reports	2023	Differential methylation of circRNA m6A in an APP/PS1 Alzheimer's disease mouse model.		chr12:16977542-16978102+	mmu_circ_Rock2	Rock2	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	unknown	RT-qPCR; RNA-seq	"This Rock2-associated circRNA exhibits significantly altered m6A methylation in APP/PS1 AD mouse brain versus controls, supported by circRNA m6A-seq and MeRIP-RT-qPCR. It is linked in discussion to Abeta production via its host gene Rock2."	0.5415
36660942	Molecular medicine reports	2023	Differential methylation of circRNA m6A in an APP/PS1 Alzheimer's disease mouse model.		chr16:8708859-8716619-			Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	unknown	RT-qPCR; RNA-seq	"This USP7-associated circRNA is among the eight circRNAs with significantly altered m6A methylation in APP/PS1 AD mouse brain. The paper links it to an anti-neuroinflammatory effect via association with the ubiquitin specific peptidase 7 gene, but does not elucidate a detailed mechanism."	0.5415
36660942	Molecular medicine reports	2023	Differential methylation of circRNA m6A in an APP/PS1 Alzheimer's disease mouse model.		chr11:108923152-108931579+	mmu_circ_Axin2	Axin2	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	unknown	RT-qPCR; RNA-seq	"This Axin2-associated circRNA is differentially m6A-methylated in APP/PS1 AD mouse brain. The paper connects its host gene to Wnt/beta-catenin signaling, which inhibits Abeta production and tau hyperphosphorylation, but does not establish a circRNA-specific mechanistic axis."	0.5415
36660942	Molecular medicine reports	2023	Differential methylation of circRNA m6A in an APP/PS1 Alzheimer's disease mouse model.		chrX:143709648-143744001+			Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	unknown	RT-qPCR; RNA-seq	"This p21 activated kinase-associated circRNA is differentially m6A-methylated in APP/PS1 AD mouse brain compared with controls. The study notes the host gene¡¯s link to neuronal apoptosis in familial AD contexts, but does not define a circRNA-specific regulatory axis."	0.5415
36660942	Molecular medicine reports	2023	Differential methylation of circRNA m6A in an APP/PS1 Alzheimer's disease mouse model.		chr5:137291102-137291478+			Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	unknown	RT-qPCR; RNA-seq	"This acetylcholinesterase-associated circRNA is differentially m6A-methylated in APP/PS1 AD mouse brain. The paper ties the host gene to cholinergic deficit and Abeta fibril toxicity in AD, while leaving the circRNA¡¯s direct mechanism unresolved."	0.5415
36660942	Molecular medicine reports	2023	Differential methylation of circRNA m6A in an APP/PS1 Alzheimer's disease mouse model.		chr1:68305845-68396315-	mmu_circ_Erbb4	Erbb4	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	unknown	RT-qPCR; RNA-seq	"This Erbb4-associated circRNA is among the eight circRNAs with significantly altered m6A methylation in APP/PS1 AD mouse brain. The discussion links Erbb4 to amyloid beta-induced neurotoxicity via JNK/tau signaling, but the circRNA¡¯s own mechanistic role is not determined."	0.5415
36661308	Annals of medicine	2023	Profiling of differentially expressed circRNAs and functional prediction in peripheral blood mononuclear cells from patients with rheumatoid arthritis.	hsa_circ_0054223	hsa_circ_0054223_CBC1 / circ_0054223	hsa_circ_THUMPD2	THUMPD2	rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0054223 is up-regulated in RA PBMCs and was validated by RT-qPCR. Bioinformatics suggests it may sponge specific miRNAs to regulate RICTOR within a circRNA_miRNA_mRNA network, and its level correlates positively with ESR/CRP (and RF)."	0.4032
36661308	Annals of medicine	2023	Profiling of differentially expressed circRNAs and functional prediction in peripheral blood mononuclear cells from patients with rheumatoid arthritis.	hsa_circ_0053881	hsa_circ_0053881_CBC1 / circ_0053881	hsa_circ_TTC27	TTC27	rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0053881 is up-regulated in RA PBMCs and validated by RT-qPCR. It is predicted to bind miRNAs (e.g., hsa-miR-141-5p and hsa-miR-646) in a ceRNA network that may influence RICTOR expression, and its level correlates positively with ESR/CRP/RF."	0.4032
36661308	Annals of medicine	2023	Profiling of differentially expressed circRNAs and functional prediction in peripheral blood mononuclear cells from patients with rheumatoid arthritis.		hsa-circRNA13773-35 / hsa-circRNA13773-35_CBC1	hsa_circ_ATR	ATR	rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; Microarray	"hsa-circRNA13773-35 is reported as an up-regulated circRNA in RA PBMCs and included among RT-qPCR-verified circRNAs. It is predicted to sponge miRNAs (hsa-let-7d-5p, hsa-miR-1265, hsa-miR-182-5p) and potentially affect RICTOR expression in a circRNA_miRNA_mRNA network."	0.4032
36661308	Annals of medicine	2023	Profiling of differentially expressed circRNAs and functional prediction in peripheral blood mononuclear cells from patients with rheumatoid arthritis.	hsa_circ_0024203	hsa_circ_0024203_CBC1 / circ_0024203	hsa_circ_ATM	ATM	rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0024203 is up-regulated in RA PBMCs and validated by RT-qPCR. It is included in a predicted ceRNA network that may influence RICTOR expression, and its expression correlates positively with ESR and CRP."	0.4032
36661308	Annals of medicine	2023	Profiling of differentially expressed circRNAs and functional prediction in peripheral blood mononuclear cells from patients with rheumatoid arthritis.	hsa_circ_0037720	hsa_circ_0037720_CBC1 / circ_0037720	hsa_circ_NMRAL1	NMRAL1	rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	down-regulated	RT-qPCR; Microarray	hsa_circ_0037720 is down-regulated in RA PBMCs and validated by RT-qPCR. Its expression is negatively correlated with RA inflammatory markers (ESR/CRP/RF).	0.4032
36661308	Annals of medicine	2023	Profiling of differentially expressed circRNAs and functional prediction in peripheral blood mononuclear cells from patients with rheumatoid arthritis.	hsa_circ_0049678	hsa_circ_0049678_CBC1 / circ_0049678	hsa_circ_CACNA1A	CACNA1A	rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	down-regulated	RT-qPCR; Microarray	hsa_circ_0049678 is down-regulated in RA PBMCs and validated by RT-qPCR. Its level is negatively correlated with RA inflammatory markers (ESR/CRP/RF).	0.4032
36661308	Annals of medicine	2023	Profiling of differentially expressed circRNAs and functional prediction in peripheral blood mononuclear cells from patients with rheumatoid arthritis.	hsa_circ_0030682	hsa_circ_0030682_CBC1 / circ_0030682	hsa_circ_FARP1	FARP1	rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	down-regulated	RT-qPCR; Microarray	hsa_circ_0030682 is down-regulated in RA PBMCs and validated by RT-qPCR. Its expression is negatively correlated with RA inflammatory markers (ESR/CRP/RF).	0.4032
36661308	Annals of medicine	2023	Profiling of differentially expressed circRNAs and functional prediction in peripheral blood mononuclear cells from patients with rheumatoid arthritis.	hsa_circ_0002557	hsa_circ_0002557_CBC1 / circ_0002557	hsa_circ_FARP1	FARP1	rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	down-regulated	RT-qPCR; Microarray	hsa_circ_0002557 is down-regulated in RA PBMCs and validated by RT-qPCR. Its expression is negatively correlated with CRP and RF in RA patients.	0.4032
36661308	Annals of medicine	2023	Profiling of differentially expressed circRNAs and functional prediction in peripheral blood mononuclear cells from patients with rheumatoid arthritis.	hsa_circ_0034644	hsa_circ_0034644_CBC1 / circ_0034644	hsa_circ_DLL4	DLL4	rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	down-regulated	RT-qPCR; Microarray	"hsa_circ_0034644 is down-regulated in RA PBMCs and included among RT-qPCR-verified DEcircRNAs. It is incorporated into a predicted circRNA_miRNA_mRNA network, but specific miRNA/mRNA partners and functional effects were not detailed in the text provided."	0.4032
36672208	Cells	2023	Silencing of circCRIM1 Drives IGF2BP1-Mediated NSCLC Immune Evasion.	hsa_circ_0002346	circCRIM1	hsa_circ_CRIM1	CRIM1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	"circCRIM1 is down-regulated in NSCLC and functions as a tumor suppressor by inhibiting immune evasion. It binds the RBP IGF2BP1 and competitively reduces IGF2BP1-mediated stabilization of HLA-F mRNA, lowering HLA-F expression and enhancing CD8+ T/NK cytotoxic responses in vitro and in xenograft models."	0.8897
36672408	Cancers	2023	CircZBTB46 Protects Acute Myeloid Leukemia Cells from Ferroptotic Cell Death by Upregulating SCD.	hsa_circ_0002805	circZBTB46 / hsa_circRNA_103104	hsa_circ_ZBTB46	ZBTB46	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; Microarray	"circZBTB46 is up-regulated in AML and functions as an oncogenic circRNA that promotes AML cell proliferation and cell-cycle progression while inhibiting ferroptosis. It mainly localizes in the cytoplasm and acts as a ceRNA (notably sponging hsa-miR-671-5p) to upregulate SCD, thereby reducing lipid peroxidation and supporting tumor growth in a cell line-derived xenograft model."	0.8745
36674813	International journal of molecular sciences	2023	CircRNA-PI4KB Induces Hepatic Lipid Deposition in Non-Alcoholic Fatty Liver Disease by Transporting miRNA-122 to Extra-Hepatocytes.	hsa_circ_0006892	circPI4KB / circRNA-PI4KB	hsa_circ_PI4KB	PI4KB	non-alcoholic fatty liver disease / NAFLD	MONDO:0013209	metabolic dysfunction-associated steatotic liver disease	dysregulated	RT-qPCR	"In NAFLD models, circPI4KB is decreased intracellularly (hepatocytes/liver tissue) but increased extracellularly (culture medium/serum). It binds miRNA-122 and promotes its export to extra-hepatocytes, lowering intra-hepatocyte miRNA-122 and thereby enhancing lipid deposition via altered lipid-metabolism genes/proteins (e.g., FAS, HMGCR, SREBP-2, AGPAT1, DGAT1)."	0.7609
36680456	Thoracic cancer	2023	Circ_0043256 upregulates KLF2 expression by absorbing miR-1206 to suppress the tumorigenesis of lung cancer.	hsa_circ_0043256	circ_0043256	hsa_circ_ACACA	ACACA	lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	"circ_0043256 is down-regulated in lung cancer and acts as a tumor suppressor. It mainly localizes to the cytoplasm and inhibits malignant phenotypes by sponging miR-1206 to increase KLF2 expression, suppressing tumor growth in vitro and in vivo."	0.7229
36681829	Experimental hematology & oncology	2023	CircFBXW7 in patients with T-cell ALL: depletion sustains MYC and NOTCH activation and leukemia cell viability.		circFBXW7	hsa_circ_FBXW7	FBXW7	T-cell Acute Lymphoblastic Leukemia / T-ALL	MONDO:0004963	T-cell acute lymphoblastic leukemia	down-regulated	RT-qPCR; RNA-seq	"In pediatric T-ALL, circFBXW7 is depleted/low in a patient subset and acts as a tumor-suppressive circRNA. Its knockdown increases leukemia cell viability and proliferation and is accompanied by activation of MYC targets and NOTCH signaling (including increased MYC and cleaved intracellular NOTCH1 protein levels), and it can increase Dexamethasone sensitivity."	0.6221
36683218	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2023	Chemotherapy-Induced Senescence Reprogramming Promotes Nasopharyngeal Carcinoma Metastasis by circRNA-Mediated PKR Activation.	hsa_circ_0000206	circWDR37	hsa_circ_WDR37	WDR37	nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"In nasopharyngeal carcinoma, circWDR37 is upregulated in highly metastatic cells and promotes chemotherapy-induced senescence-associated metastasis. It binds PKR in the cytoplasm, induces PKR homodimerization/phosphorylation, activates NF-kappaB, and increases CCND1 and proinflammatory SASP gene transcription, leading to enhanced migration/invasion. Clinically, high circWDR37 associates with poor survival and reduced induction-chemotherapy benefit."	0.9016
36684043	World journal of gastrointestinal oncology	2023	Hsa_circ_0001658 accelerates the progression of colorectal cancer through miR-590-5p/METTL3 regulatory axis.	hsa_circ_0001658	circRNA_0001658 / circ_0001658			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"In colorectal cancer, circ_0001658 is up-regulated in tissues and CRC cell lines and acts as an oncogenic circRNA. It mainly localizes to the cytoplasm and promotes proliferation and cell-cycle progression while inhibiting apoptosis by sponging miR-590-5p to increase METTL3 expression."	0.7519
36684328	Frontiers in surgery	2022	Construction and analysis of a survival-associated competing endogenous RNA network in breast cancer.	hsa_circ_0105136				breast cancer / BC	MONDO:0007254	breast cancer	unknown	Microarray	"This circRNA was identified from GEO circRNA microarrays and incorporated into a survival-associated ceRNA network in breast cancer. The study proposes a circRNA/miRNA/mRNA axis involving hsa-miR-548c and CCNB1 that may relate to BC progression and prognosis, but the circRNA itself was not experimentally validated."	0.1768
36684328	Frontiers in surgery	2022	Construction and analysis of a survival-associated competing endogenous RNA network in breast cancer.	hsa_circ_0118577				breast cancer / BC	MONDO:0007254	breast cancer	unknown	Microarray	"This circRNA was identified from GEO circRNA microarrays and incorporated into a survival-associated ceRNA network in breast cancer. The study proposes a circRNA/miRNA/mRNA axis involving hsa-miR-548c and CCNB1 that may relate to BC progression and prognosis, but the circRNA itself was not experimentally validated."	0.1768
36685959	Frontiers in genetics	2022	Identification of an unrecognized circRNA associated with development of renal fibrosis.	hsa_circ_0002158	circRNA_0002158 / circ_0002158			renal fibrosis / RF	MONDO:0000494	renal fibrosis	down-regulated	RT-qPCR; RNA-seq	"circ_0002158 is down-regulated in renal fibrosis models (rat UUO kidneys and TGF-beta1-treated HK-2 cells). Functional assays show that its overexpression promotes HK-2 cell proliferation, inhibits apoptosis, and reduces fibrosis-associated markers FN and PAI-1, suggesting an anti-fibrotic role; mechanistic insights are mainly based on iTRAQ/GO/KEGG enrichment, with ceRNA sponging proposed but not validated."	0.6111
36685959	Frontiers in genetics	2022	Identification of an unrecognized circRNA associated with development of renal fibrosis.	rno_circ_0002158	circRNA_0002158			renal fibrosis / RF	MONDO:0000494	renal fibrosis	down-regulated	RT-qPCR; RNA-seq	"circ_0002158 is down-regulated in renal fibrosis models (rat UUO kidneys and TGF-beta1-treated HK-2 cells). Functional assays show that its overexpression promotes HK-2 cell proliferation, inhibits apoptosis, and reduces fibrosis-associated markers FN and PAI-1, suggesting an anti-fibrotic role; mechanistic insights are mainly based on iTRAQ/GO/KEGG enrichment, with ceRNA sponging proposed but not validated."	0.6111
36686977	Evidence-based complementary and alternative medicine : eCAM	2023	"Circular RNA SMARCA5 Modulates Epithelial-Mesenchymal Transformation, Proliferation, and Metastasis of Nasopharyngeal Carcinoma Cells via microRNA-582-3p/Phosphatase and Tensin Homolog Axis."		circSMARCA5 / circular RNA SMARCA5	hsa_circ_SMARCA5	SMARCA5	nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"circSMARCA5 is up-regulated in nasopharyngeal carcinoma tissues and cell lines and promotes malignant behaviors (proliferation, migration, invasion, EMT) while inhibiting apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-582-3p to increase PTEN, forming a circSMARCA5/miR-582-3p/PTEN axis."	0.6536
36691031	Molecular cancer	2023	A novel polypeptide encoded by the circular RNA ZKSCAN1 suppresses HCC via degradation of mTOR.	hsa_circ_0001727	circZKSCAN1 / cicZKSCAN1	hsa_circ_ZKSCAN1	ZKSCAN1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	circZKSCAN1 is down-regulated in HCC tissues/cell lines and suppresses HCC cell growth while increasing sorafenib sensitivity. The study indicates its main functional output in HCC is likely via encoding the peptide circZKSaa rather than acting as a miRNA sponge.	0.6578
36691322	Thoracic cancer	2023	Circ_0110498 facilitates the cisplatin resistance of non-small cell lung cancer by mediating the miR-1287-5p/RBBP4 axis.	hsa_circ_0110498	circ_0110498	hsa_circ_MAGI3	MAGI3	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0110498 is up-regulated in NSCLC, especially in cisplatin (DDP)-resistant tissues/cells, and promotes DDP resistance, proliferation, migration/invasion, and glycolysis while suppressing apoptosis. Mechanistically, it functions as a ceRNA by sponging miR-1287-5p to derepress RBBP4, and circ_0110498 knockdown increases DDP sensitivity in vitro and in a xenograft model."	0.8037
36691537	Heliyon	2023	circAR-E2E4-miR-665-STAT3 axis is a potential regulatory network in triple-negative breast cancer.		circAR-E2E4	hsa_circ_AR	AR	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"circAR-E2E4 (from the AR gene) promotes TNBC cell proliferation and is positively regulated by AR. Mechanistically, circAR-E2E4 acts as a miRNA sponge (miR-665/miR-671-5p), and circAR-E2E4 knockdown decreases STAT3 mRNA/protein, supporting a circAR-E2E4_miR-665_STAT3 regulatory axis in TNBC."	0.7164
36694626	"Open medicine (Warsaw, Poland)"	2023	circRNA ITGA7 restrains growth and enhances radiosensitivity by up-regulating SMAD4 in colorectal carcinoma.	hsa_circ_0026782	circ_ITGA7	hsa_circ_ITGA7	ITGA7	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"circ_ITGA7 is down-regulated in colorectal cancer and higher expression correlates with longer overall survival. Functionally, circ_ITGA7 suppresses CRC growth and increases radiosensitivity by sponging miR-766 to up-regulate SMAD4, leading to reduced proliferation, G0/G1 arrest, increased irradiation-induced apoptosis, and inhibition of EMT."	0.7859
36694911	Bioengineered	2022	CircRNA hsa_circ_0070659 predicts poor prognosis and promotes non-small cell lung cancer (NSCLC) progression via microRNA-377 (miR-377) / Ras-Associated Binding Protein 3C (RAB3C) pathway.	hsa_circ_0070659	circ_0070659	hsa_circ_CCDC109B	CCDC109B	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0070659 (hsa_circ_0070659), derived from CCDC109B, is up-regulated in NSCLC tissues and cell lines and shows strong diagnostic performance by ROC analysis. It promotes NSCLC proliferation, migration, and invasion by sponging miR-377 and thereby sustaining RAB3C expression (circ_0070659/miR-377/RAB3C ceRNA axis)."	0.8586
36697384	Cell death & disease	2023	Characterization of circSCL38A1 as a novel oncogene in bladder cancer via targeting ILF3/TGF-beta2 signaling axis.	hsa_circ_0000396	circSLC38A1	hsa_circ_SLC38A1	SLC38A1	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circSLC38A1 (hsa_circ_0000396), derived from SLC38A1, is up-regulated in bladder cancer tissues/cell lines and promotes migration, invasion, EMT and lung metastasis. Mechanistically, it binds the RBP ILF3, inhibits ILF3 ubiquitination to stabilize ILF3, and facilitates ILF3-dependent transcriptional activation of TGF-beta2; its upregulation is supported by m6A modification (METTL3/FTO-related). Clinically, high tumor expression predicts poorer OS, and serum exosomal circSLC38A1 shows diagnostic value (AUC 0.878)."	0.9013
36699282	Heliyon	2023	Circ-ATIC regulates esophageal squamous cell carcinoma growth and metastasis through miR-1294/PBX3 pathway.	hsa_circ_0058063	circ-ATIC / circRNA_0058063	hsa_circ_ATIC	ATIC	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"circ-ATIC is up-regulated in ESCC tissues/cells and promotes proliferation, invasion, EMT and xenograft growth. Mechanistically, it acts as a ceRNA sponging miR-1294 to increase PBX3 expression, driving ESCC progression."	0.8319
36700045	Molecular therapy. Nucleic acids	2023	Exosomal circ-PTPN22 and circ-ADAMTS6 mark T cell exhaustion and neutrophil extracellular traps in Asian intrahepatic cholangiocarcinoma.	hsa_circ_0110529	circ-PTPN22	hsa_circ_PTPN22	PTPN22	intrahepatic cholangiocarcinoma / ICC	MONDO:0003210	intrahepatic cholangiocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circ-PTPN22 is up-regulated in an immunogenic Asian ICC subgroup (subgroup 2) and is elevated in both tumor tissues and plasma exosomes, marking T cell exhaustion and neutrophil extracellular traps. The study validates its circular nature and upregulation by qRT-PCR, Sanger sequencing of the back-splice junction, and RNase R resistance, supporting its potential as a liquid-biopsy biomarker."	0.6193
36700045	Molecular therapy. Nucleic acids	2023	Exosomal circ-PTPN22 and circ-ADAMTS6 mark T cell exhaustion and neutrophil extracellular traps in Asian intrahepatic cholangiocarcinoma.	hsa_circ_0072688	circ-ADAMTS6	hsa_circ_ADAMTS6	ADAMTS6	intrahepatic cholangiocarcinoma / ICC	MONDO:0003210	intrahepatic cholangiocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circ-ADAMTS6 is up-regulated in an immunogenic Asian ICC subgroup (subgroup 2) and is elevated in both tumor tissues and plasma exosomes, marking T cell exhaustion and neutrophil extracellular traps. The study validates its back-splice junction and circular features (RNase R resistance) and confirms upregulation by qRT-PCR, supporting its use as a plasma exosomal biomarker."	0.6193
36700234	Frontiers in immunology	2022	Identification and comprehensive analysis of circRNA-miRNA-mRNA regulatory networks in osteoarthritis.	hsa_circ_0027914				osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0027914 is up-regulated in osteoarthritic cartilage and functions as a hub circRNA in a predicted circRNA_miRNA_mRNA network. siRNA-mediated silencing reduces IL-1beta-induced chondrocyte apoptosis, decreases IL-6/TNF-alpha secretion, and restores proliferation, consistent with a pro-apoptotic and pro-inflammatory role in OA."	0.6777
36700234	Frontiers in immunology	2022	Identification and comprehensive analysis of circRNA-miRNA-mRNA regulatory networks in osteoarthritis.	hsa_circ_0101125				osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0101125 is up-regulated in osteoarthritic cartilage and is a hub circRNA in the constructed circRNA_miRNA_mRNA network, predicted to regulate miRNAs including hsa-miR-3202, hsa-miR-4516, hsa-miR-1275 and hsa-miR-4476. Silencing in an IL-1beta-treated C28/I2 chondrocyte model reduces apoptosis and inflammatory cytokine secretion and restores proliferation, supporting a pathogenic role in OA."	0.6777
36700234	Frontiers in immunology	2022	Identification and comprehensive analysis of circRNA-miRNA-mRNA regulatory networks in osteoarthritis.	hsa_circ_0102564				osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0102564 is up-regulated in osteoarthritic cartilage and is a hub circRNA in the predicted circRNA_miRNA_mRNA network, regulating miRNAs including hsa-miR-766-5p and hsa-miR-30c-1-3p. Functional knockdown in IL-1beta-treated C28/I2 chondrocytes reduces apoptosis and inflammatory cytokine secretion and restores proliferation, supporting a pro-apoptotic/pro-inflammatory role in OA."	0.6777
36700234	Frontiers in immunology	2022	Identification and comprehensive analysis of circRNA-miRNA-mRNA regulatory networks in osteoarthritis.		hsa_circ_00009			osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; Microarray	"hsa_circ_00009 was validated by RT-PCR and shown to be up-regulated in OA cartilage compared with non-arthritic cartilage in this study, but no functional mechanism was further characterized."	0.4773
36700234	Frontiers in immunology	2022	Identification and comprehensive analysis of circRNA-miRNA-mRNA regulatory networks in osteoarthritis.	hsa_circ_0102566				osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0102566 was validated by RT-PCR and shown to be up-regulated in OA cartilage compared with non-arthritic cartilage in this study, but its mechanism was not further investigated."	0.4773
36700234	Frontiers in immunology	2022	Identification and comprehensive analysis of circRNA-miRNA-mRNA regulatory networks in osteoarthritis.	hsa_circ_0102565				osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0102565 was validated by RT-PCR and shown to be up-regulated in OA cartilage compared with non-arthritic cartilage in this study, but no downstream mechanism was experimentally characterized."	0.4773
36700234	Frontiers in immunology	2022	Identification and comprehensive analysis of circRNA-miRNA-mRNA regulatory networks in osteoarthritis.	hsa_circ_0104561				osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0104561 was validated by RT-PCR and shown to be up-regulated in OA cartilage compared with non-arthritic cartilage in this study, without further functional characterization."	0.4773
36700234	Frontiers in immunology	2022	Identification and comprehensive analysis of circRNA-miRNA-mRNA regulatory networks in osteoarthritis.	hsa_circ_0082680				osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0082680 was validated by RT-PCR and shown to be up-regulated in OA cartilage compared with non-arthritic cartilage in this study, with no additional mechanistic validation reported."	0.4773
36700234	Frontiers in immunology	2022	Identification and comprehensive analysis of circRNA-miRNA-mRNA regulatory networks in osteoarthritis.	hsa_circ_0002643				osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0002643 was validated by RT-PCR and shown to be up-regulated in OA cartilage compared with non-arthritic cartilage in this study, but no functional experiments were reported for this circRNA."	0.4773
36700234	Frontiers in immunology	2022	Identification and comprehensive analysis of circRNA-miRNA-mRNA regulatory networks in osteoarthritis.	hsa_circ_0000787				osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000787 was validated by RT-PCR and shown to be up-regulated in OA cartilage compared with non-arthritic cartilage in this study, but no OA-related mechanism was experimentally examined."	0.4773
36700234	Frontiers in immunology	2022	Identification and comprehensive analysis of circRNA-miRNA-mRNA regulatory networks in osteoarthritis.	hsa_circ_0048766				osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0048766 was validated by RT-PCR and shown to be up-regulated in OA cartilage compared with non-arthritic cartilage in this study, but no mechanistic experiments were performed for this circRNA."	0.4773
36700234	Frontiers in immunology	2022	Identification and comprehensive analysis of circRNA-miRNA-mRNA regulatory networks in osteoarthritis.	hsa_circ_0102400				osteoarthritis / OA	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR; Microarray	"hsa_circ_0102400 was validated by RT-PCR and found to be down-regulated in OA cartilage compared with non-arthritic cartilage in this study, without further mechanistic investigation."	0.4773
36701487	Journal of cardiovascular pharmacology	2023	"Key circRNAs, lncRNAs, and mRNAs of ShenQi Compound in Protecting Vascular Endothelial Cells From High Glucose Identified by Whole Transcriptome Sequencing."		circRNA.3121			Type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RT-qPCR; RNA-seq	circRNA.3121 is down-regulated in diabetic/hyperglycemic rat thoracic aorta and is reversed toward normal levels after ShenQi Compound treatment. The study positions circRNA.3121 as a key ncRNA potentially mediating SQC¡¯s protective effects against endothelial oxidative stress and apoptosis; prior work cited suggests it may act as a miRNA sponge.	0.4852
36709365	Communications biology	2023	circRNA432 enhances the coelomocyte phagocytosis via regulating the miR-2008-ELMO1 axis in Vibrio splendidus-challenged Apostichopus japonicus.		circRNA432 / circ432			Vibrio splendidus-challenged	MONDO:0007014	vibrio infectious disease	up-regulated	RT-qPCR; RNA-seq	"circ432 is up-regulated in sea cucumbers under SUS and is induced by Vibrio splendidus/LPS challenge. It promotes coelomocyte phagocytosis by acting as a ceRNA that sponges miR-2008, thereby increasing AjELMO1 mRNA/protein abundance."	0.7924
36712253	Frontiers in cardiovascular medicine	2022	Identification of pathological-related and diagnostic potential circular RNAs in Stanford type A aortic dissection.		circPTGR1	hsa_circ_PTGR1	PTGR1	Stanford type A aortic dissection / TAAD	MONDO:0022470	aortic dissection lentiginosis	up-regulated	RT-qPCR; RNA-seq	"circPTGR1 is up-regulated in TAAD (aortic tissue and serum) and shows strong diagnostic performance. Mechanistically, it is implicated in a predicted ceRNA axis circPTGR1_miR-26b_HMGA2 and is associated with inflammatory responses and ECM/stromal loss in TAAD."	0.5047
36712253	Frontiers in cardiovascular medicine	2022	Identification of pathological-related and diagnostic potential circular RNAs in Stanford type A aortic dissection.		circNOX4	hsa_circ_NOX4	NOX4	Stanford type A aortic dissection / TAAD	MONDO:0022470	aortic dissection lentiginosis	up-regulated	RT-qPCR; RNA-seq	"circNOX4 is up-regulated in TAAD (aortic tissue and serum) and has diagnostic value. It is associated with inflammatory infiltration and stromal/VSMC loss in TAAD, with mechanisms explored mainly through bioinformatic ceRNA/pathology correlation analyses rather than a specified miRNA/mRNA pair for this circRNA."	0.5047
36712253	Frontiers in cardiovascular medicine	2022	Identification of pathological-related and diagnostic potential circular RNAs in Stanford type A aortic dissection.		circAMN1	hsa_circ_AMN1	AMN1	Stanford type A aortic dissection / TAAD	MONDO:0022470	aortic dissection lentiginosis	up-regulated	RT-qPCR; RNA-seq	"circAMN1 is up-regulated in TAAD and validated in patient serum, showing good diagnostic performance. Bioinformatic analyses suggest it is linked to TAAD pathological features, especially inflammatory infiltration and stromal loss, via predicted ceRNA interactions."	0.5047
36712253	Frontiers in cardiovascular medicine	2022	Identification of pathological-related and diagnostic potential circular RNAs in Stanford type A aortic dissection.		circUSP3	hsa_circ_USP3	USP3	Stanford type A aortic dissection / TAAD	MONDO:0022470	aortic dissection lentiginosis	up-regulated	RT-qPCR; RNA-seq	"circUSP3 is up-regulated in TAAD and validated in patient serum, with the strongest diagnostic performance among the four circRNAs. It is linked to TAAD pathological signatures (inflammation and stromal/ECM-related changes) through predicted miRNA-mediated regulation and correlates negatively with VSMC score."	0.5047
36712438	Frontiers in neurology	2022	Expression characteristics of circular RNA in human traumatic brain injury.		circRNA EPS15	hsa_circ_EPS15	Eps15	Traumatic brain injury / TBI	MONDO:0858950	traumatic brain injury	up-regulated	RT-qPCR; RNA-seq	"circRNA EPS15 is significantly up-regulated in human TBI brain tissues versus adjacent contusion tissues and was validated by RT-qPCR. The study predicts EPS15 may participate in TBI-related processes via a circRNA_miRNA_mRNA ceRNA network (predicted miRNA: hsa-miR-2682-5p), but no direct functional experiments were performed."	0.5135
36712438	Frontiers in neurology	2022	Expression characteristics of circular RNA in human traumatic brain injury.		circRNA FGD4	hsa_circ_FGD4	FGD4	Traumatic brain injury / TBI	MONDO:0858950	traumatic brain injury	up-regulated	RT-qPCR; RNA-seq	"FGD4 circRNA is up-regulated in human TBI brain tissue and its differential expression was validated by RT-qPCR. The study predicts its potential miRNA interactions (hsa-miR-487a-3p, hsa-miR-136-5p) within a constructed ceRNA network, but no functional experiments were conducted."	0.5135
36712438	Frontiers in neurology	2022	Expression characteristics of circular RNA in human traumatic brain injury.		circRNA TPCN1	hsa_circ_TPCN1	TPCN1	Traumatic brain injury / TBI	MONDO:0858950	traumatic brain injury	up-regulated	RT-qPCR; RNA-seq	TPCN1 circRNA is up-regulated in human TBI brain tissue and validated by RT-qPCR. The paper reports predicted binding with hsa-miR-409-5p and includes it in a bioinformatically constructed ceRNA network without downstream mechanistic validation.	0.5135
36712438	Frontiers in neurology	2022	Expression characteristics of circular RNA in human traumatic brain injury.		circRNA PUM2	hsa_circ_PUM2	PUM2	Traumatic brain injury / TBI	MONDO:0858950	traumatic brain injury	up-regulated	RT-qPCR; RNA-seq	"PUM2 circRNA is up-regulated in human TBI brain tissue and validated by RT-qPCR. The study predicts interaction with hsa-miR-136-3p and places it in a ceRNA network, but provides no functional validation."	0.5135
36712438	Frontiers in neurology	2022	Expression characteristics of circular RNA in human traumatic brain injury.		circRNA CADPS2	hsa_circ_CADPS2	CADPS2	Traumatic brain injury / TBI	MONDO:0858950	traumatic brain injury	up-regulated	RT-qPCR; RNA-seq	"CADPS2 circRNA is up-regulated in human TBI brain tissue and validated by RT-qPCR. The paper predicts it targets hsa-miR-654-3p and hsa-miR-1298-5p as part of a constructed ceRNA network, without functional validation."	0.5135
36712438	Frontiers in neurology	2022	Expression characteristics of circular RNA in human traumatic brain injury.		circRNA AKT3	hsa_circ_AKT3	AKT3	Traumatic brain injury / TBI	MONDO:0858950	traumatic brain injury	down-regulated	RT-qPCR; RNA-seq	AKT3 circRNA is significantly down-regulated in human TBI brain tissue and this change was validated by RT-qPCR. The study does not provide specific mechanistic or functional validation for AKT3 circRNA beyond differential expression.	0.4773
36712438	Frontiers in neurology	2022	Expression characteristics of circular RNA in human traumatic brain injury.		circRNA ZZZ3	hsa_circ_ZZZ3	ZZZ3	Traumatic brain injury / TBI	MONDO:0858950	traumatic brain injury	down-regulated	RT-qPCR; RNA-seq	ZZZ3 circRNA is down-regulated in human TBI brain tissue and validated by RT-qPCR. No specific downstream mechanism or interaction was experimentally validated for this circRNA in the study.	0.4773
36712438	Frontiers in neurology	2022	Expression characteristics of circular RNA in human traumatic brain injury.		circRNA ATRNL1	hsa_circ_ATRNL1	ATRNL1	Traumatic brain injury / TBI	MONDO:0858950	traumatic brain injury	down-regulated	RT-qPCR; RNA-seq	ATRNL1 circRNA is down-regulated in human TBI brain tissue and validated by RT-qPCR. No specific mechanistic or functional evidence is provided beyond differential expression.	0.4773
36712438	Frontiers in neurology	2022	Expression characteristics of circular RNA in human traumatic brain injury.		circRNA MINDY3	hsa_circ_MINDY3	MINDY3	Traumatic brain injury / TBI	MONDO:0858950	traumatic brain injury	down-regulated	RT-qPCR; RNA-seq	MINDY3 circRNA is down-regulated in human TBI brain tissue and validated by RT-qPCR. The study does not provide mechanistic or functional validation for this circRNA beyond expression change.	0.4773
36712438	Frontiers in neurology	2022	Expression characteristics of circular RNA in human traumatic brain injury.		circRNA DPYD	hsa_circ_DPYD	DPYD	Traumatic brain injury / TBI	MONDO:0858950	traumatic brain injury	down-regulated	RT-qPCR; RNA-seq	DPYD circRNA is down-regulated in human TBI brain tissue and validated by RT-qPCR. The study reports no specific molecular mechanism for DPYD circRNA beyond differential expression.	0.4773
36713424	Frontiers in immunology	2022	Differential expression profiles and functional prediction of circRNA in mice with traumatic heterotopic ossification.		mmu_circRNA_29625	mmu_circ_Pdia5	Pdia5	traumatic heterotopic ossification / HO	MONDO:0002081	musculoskeletal system disorder	up-regulated	RT-qPCR; Microarray	"mmu_circRNA_29625 (host gene Pdia5) is upregulated in mouse traumatic HO lesions. Bioinformatics network analysis suggests it may act as a ceRNA by sponging mmu_miR-34a-5p to influence targets such as Notch1/Notch signaling, potentially promoting osteogenic differentiation and HO formation."	0.3401
36713424	Frontiers in immunology	2022	Differential expression profiles and functional prediction of circRNA in mice with traumatic heterotopic ossification.		mmu_circRNA_24245	mmu_circ_Cdc27	Cdc27	traumatic heterotopic ossification / HO	MONDO:0002081	musculoskeletal system disorder	up-regulated	RT-qPCR; Microarray	"mmu_circRNA_24245 (host gene Cdc27) is upregulated in mouse traumatic HO tissues and validated by qRT-PCR. Network prediction suggests a ceRNA axis mmu_circRNA_24245/mmu_miR-129b-5p/Sox4 that may promote HO formation, potentially linked to EMT and related osteogenic programs."	0.3858
36713424	Frontiers in immunology	2022	Differential expression profiles and functional prediction of circRNA in mice with traumatic heterotopic ossification.		mmu_circRNA_43813	mmu_circ_Zfp426	Zfp426	traumatic heterotopic ossification / HO	MONDO:0002081	musculoskeletal system disorder	up-regulated	RT-qPCR; Microarray	"mmu_circRNA_43813 (host gene Zfp426) is upregulated in mouse traumatic HO tissues and its differential expression was verified by qRT-PCR, but no specific downstream miRNA/mRNA mechanism was experimentally established in this study."	0.3401
36713424	Frontiers in immunology	2022	Differential expression profiles and functional prediction of circRNA in mice with traumatic heterotopic ossification.		mmu_circRNA_34414	mmu_circ_Map1a	Map1a	traumatic heterotopic ossification / HO	MONDO:0002081	musculoskeletal system disorder	up-regulated	RT-qPCR; Microarray	mmu_circRNA_34414 (host gene Map1a) is upregulated in mouse traumatic HO tissues and was validated by qRT-PCR; the study did not provide a specific downstream functional mechanism for this circRNA.	0.3401
36713424	Frontiers in immunology	2022	Differential expression profiles and functional prediction of circRNA in mice with traumatic heterotopic ossification.		mmu_circRNA_21813	mmu_circ_Ncoa7	Ncoa7	traumatic heterotopic ossification / HO	MONDO:0002081	musculoskeletal system disorder	up-regulated	RT-qPCR; Microarray	mmu_circRNA_21813 (host gene Ncoa7) is upregulated in mouse traumatic HO tissues and was validated by qRT-PCR; no specific mechanistic axis was established for this circRNA in the paper.	0.3401
36713424	Frontiers in immunology	2022	Differential expression profiles and functional prediction of circRNA in mice with traumatic heterotopic ossification.		mmu_circRNA_37783	mmu_circ_Srrm1	Srrm1	traumatic heterotopic ossification / HO	MONDO:0002081	musculoskeletal system disorder	up-regulated	RT-qPCR; Microarray	mmu_circRNA_37783 (host gene Srrm1) is upregulated in mouse traumatic HO tissues and was validated by qRT-PCR; the study did not further define its specific downstream interactions or pathways.	0.3401
36713424	Frontiers in immunology	2022	Differential expression profiles and functional prediction of circRNA in mice with traumatic heterotopic ossification.		mmu_circRNA_41257			traumatic heterotopic ossification / HO	MONDO:0002081	musculoskeletal system disorder	down-regulated	RT-qPCR; Microarray	mmu_circRNA_41257 is downregulated in mouse traumatic HO tissues and was validated by qRT-PCR; the study did not report host gene annotation or specific functional/mechanistic links for this circRNA.	0.3401
36713424	Frontiers in immunology	2022	Differential expression profiles and functional prediction of circRNA in mice with traumatic heterotopic ossification.		mmu_circRNA_000595			traumatic heterotopic ossification / HO	MONDO:0002081	musculoskeletal system disorder	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_000595 is downregulated in mouse traumatic HO tissues and validated by qRT-PCR. It was also included in predicted circRNA_miRNA interaction and circRNA_miRNA_mRNA network analyses, suggesting a potential ceRNA role, though specific miRNA/mRNA partners were not named in the provided text."	0.3858
36713424	Frontiers in immunology	2022	Differential expression profiles and functional prediction of circRNA in mice with traumatic heterotopic ossification.		mmu_circRNA_35735			traumatic heterotopic ossification / HO	MONDO:0002081	musculoskeletal system disorder	down-regulated	RT-qPCR; Microarray	mmu_circRNA_35735 is downregulated in mouse traumatic HO tissues and validated by qRT-PCR; no host gene or detailed functional mechanism was reported for this circRNA in the provided text.	0.3401
36713424	Frontiers in immunology	2022	Differential expression profiles and functional prediction of circRNA in mice with traumatic heterotopic ossification.		mmu_circRNA_36033			traumatic heterotopic ossification / HO	MONDO:0002081	musculoskeletal system disorder	down-regulated	RT-qPCR; Microarray	mmu_circRNA_36033 is downregulated in mouse traumatic HO tissues and validated by qRT-PCR; no host gene or specific mechanism was reported for this circRNA in the provided text.	0.3401
36713424	Frontiers in immunology	2022	Differential expression profiles and functional prediction of circRNA in mice with traumatic heterotopic ossification.		mmu_circRNA_41256			traumatic heterotopic ossification / HO	MONDO:0002081	musculoskeletal system disorder	down-regulated	RT-qPCR; Microarray	mmu_circRNA_41256 is downregulated in mouse traumatic HO tissues and validated by qRT-PCR; the paper did not describe host gene annotation or a specific mechanistic axis for this circRNA in the provided text.	0.3401
36717587	Nature communications	2023	FTO-dependent m6A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke.		circSCMH1 / circular RNA SCMH1	hsa_circ_SCMH1	SCMH1	ischemic stroke / IS	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR	"circSCMH1 is down-regulated after ischemic stroke and, when supplemented (EV-delivered/overexpressed), promotes vascular repair and BBB restoration. Mechanistically, it binds FTO and enhances UBC13-dependent Ub-K63 ubiquitination and nuclear translocation of FTO, reducing m6A on Plpp3 mRNA, increasing Plpp3/LPP3 expression via improved mRNA stability, and thereby improving stroke recovery."	0.7198
36717587	Nature communications	2023	FTO-dependent m6A modification of Plpp3 in circSCMH1-regulated vascular repair and functional recovery following stroke.		circSCMH1 / circular RNA SCMH1	mmu_circ_SCMH1	SCMH1	ischemic stroke / IS	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR	"circSCMH1 is down-regulated after ischemic stroke and, when supplemented (EV-delivered/overexpressed), promotes vascular repair and BBB restoration. Mechanistically, it binds FTO and enhances UBC13-dependent Ub-K63 ubiquitination and nuclear translocation of FTO, reducing m6A on Plpp3 mRNA, increasing Plpp3/LPP3 expression via improved mRNA stability, and thereby improving stroke recovery."	0.7198
36718632	Turkish journal of haematology : official journal of Turkish Society of Haematology	2023	"Circular RNA PVT1 Regulates Cell Proliferation, Migration, and Apoptosis by Stabilizing c-Myc and Downstream Target CXCR4 Expression in Acute Myeloid Leukemia."		circular RNA PVT1 / circPVT1	hsa_circ_PVT1	PVT1	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"circPVT1 is up-regulated in AML bone marrow samples and AML cell lines and its high expression is associated with shorter OS and RFS. Functionally, circPVT1 promotes THP-1 cell proliferation and migration and inhibits apoptosis. Mechanistically, circPVT1 stabilizes c-Myc protein (via reduced Thr-58 phosphorylation) and enhances downstream CXCR4 expression, and c-Myc overexpression partially rescues circPVT1 knockdown effects."	0.6898
36718915	The Kaohsiung journal of medical sciences	2023	Dexmedetomidine promotes ferroptotic cell death in gastric cancer via hsa_circ_0008035/miR-302a/E2F7 axis.	hsa_circ_0008035	circ0008035	hsa_circ_EXT1	EXT1	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"In gastric cancer cells, DEX decreases circ0008035, promoting ferroptosis. circ0008035 counteracts DEX-induced ferroptotic cell death by sponging miR-302a to maintain E2F7 expression, affecting ROS/iron/GSH and GPX4/SLC7A11 levels."	0.6835
36719624	Biochemical genetics	2023	CircRNA Circ_0000118 Regulates Malignancy of Cervical Cancer Cells by Regulating miR-211-5p/miR-377-3p/AKT2 Axis.	hsa_circ_0000118	circ_0000118			cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ_0000118 is up-regulated in cervical cancer tissues and cell lines and acts as an oncogenic circRNA. It promotes malignant behaviors (proliferation, invasion, sphere formation, angiogenesis) and tumor growth by sponging miR-211-5p and miR-377-3p to maintain AKT2 expression."	0.8677
36721776	PeerJ	2023	Comprehensive profile and contrastive analysis of circular RNA expression in cervical squamous carcinoma and adenocarcinoma.	hsa_circ_0035811		hsa_circ_HERC1	HERC1	cervical cancer / CC	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0035811 (host gene HERC1) is a key candidate circRNA associated with the ubiquitin mediated proteolysis gene set and is experimentally validated as down-regulated in HPV-16 mediated SCC and ADC tissues versus adjacent normal tissues. It was included in a predicted circRNA_miRNA_mRNA (ceRNA) network connecting candidate circRNAs with target miRNAs and host-gene mRNAs.	0.5135
36721776	PeerJ	2023	Comprehensive profile and contrastive analysis of circular RNA expression in cervical squamous carcinoma and adenocarcinoma.	hsa_circ_0005325		hsa_circ_UBA2	UBA2	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0005325 (host gene UBA2) is a key candidate circRNA linked to the ubiquitin mediated proteolysis gene set and is validated by qRT-PCR as up-regulated in HPV-16 mediated SCC and ADC tissues versus adjacent normal tissues. It was used to construct a predicted circRNA_miRNA_mRNA (ceRNA) network involving target miRNAs and host-gene mRNAs.	0.5135
36721776	PeerJ	2023	Comprehensive profile and contrastive analysis of circular RNA expression in cervical squamous carcinoma and adenocarcinoma.	hsa_circ_0005728		hsa_circ_UBE2D2	UBE2D2	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0005728 (host gene UBE2D2) is a key candidate circRNA related to the ubiquitin mediated proteolysis gene set and is validated by qRT-PCR as up-regulated in HPV-16 mediated SCC and ADC tissues versus adjacent normal tissues. It contributed to the construction of a predicted circRNA_miRNA_mRNA (ceRNA) network with host genes as downstream mRNA nodes.	0.5135
36721776	PeerJ	2023	Comprehensive profile and contrastive analysis of circular RNA expression in cervical squamous carcinoma and adenocarcinoma.	hsa_circ_0059960		hsa_circ_ITCH	ITCH	cervical cancer / CC	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0059960 (host gene ITCH) is a key candidate circRNA from the ubiquitin mediated proteolysis-associated set and is validated by qRT-PCR as down-regulated in HPV-16 mediated SCC and ADC tissues compared with adjacent normal tissues. It was incorporated into a predicted circRNA_miRNA_mRNA (ceRNA) network centered on host genes.	0.5135
36724259	Proceedings of the National Academy of Sciences of the United States of America	2023	A virus-induced circular RNA maintains latent infection of Kaposi's sarcoma herpesvirus.	hsa_circ_0001400	circ_0001400 / circRELL1	hsa_circ_RELL1	RELL1	Kaposi¡¯s sarcoma	MONDO:0005055	Kaposi's sarcoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"hsa_circ_0001400 (circ_0001400/circRELL1) is induced after KSHV and other herpesvirus infections and biases infected endothelial cells toward latency by suppressing lytic transcription and virion production. Mechanistically, it interacts with the splicing factor PNISR and binds host transcripts including the mTOR-component TTI1, helping sustain TTI1 levels and promoting PI3K/AKT/mTOR-associated pro-growth, anti-apoptotic and immune-gene programs."	0.9083
36727735	Anti-cancer drugs	2023	Circular RNA SMARCA5 inhibits cholangiocarcinoma via microRNA-95-3p/tumor necrosis factor receptor associated factor 3 axis.		circRNA SMARCA5 / SMARCA5	hsa_circ_SMARCA5	SMARCA5	cholangiocarcinoma / CCA	MONDO:0019087	cholangiocarcinoma	down-regulated	RT-qPCR	"CircRNA SMARCA5 is down-regulated in cholangiocarcinoma tissues and cell lines. Its overexpression suppresses proliferation and increases apoptosis, mechanistically by binding miRNA-95-3p and relieving miRNA-95-3p-mediated repression of TRAF3 (circRNA SMARCA5/miRNA-95-3p/TRAF3 axis)."	0.6479
36732659	Oncogene	2023	circIPO7 dissociates caprin-1 from ribosomes and inhibits gastric cancer cell proliferation by suppressing EGFR and mTOR.	hsa_circ_0005092	circIPO7	hsa_circ_IPO7	IPO7	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; RNA-seq	"circIPO7 is down-regulated in gastric cancer and functions as a tumor suppressor by inhibiting cell proliferation and xenograft growth. Mechanistically, circIPO7 binds the RBP caprin-1, competitively disrupts caprin-1_G3BP1 interaction, prevents caprin-1/target mRNAs (EGFR, mTOR) from associating with ribosomes, and suppresses PI3K/AKT/mTOR signaling via translational inhibition of EGFR and mTOR."	0.8487
36733404	BioMed research international	2023	Circular RNA circ_0026218 Suppressed Atherosclerosis Progression via miR-338-3p/SIRT6 Axis.	hsa_circ_0026218	circRNA 0026218 / circ_0026218			atherosclerosis / AS	MONDO:0005311	atherosclerosis	down-regulated	RT-qPCR; Microarray	"circ_0026218 is down-regulated in ox-LDL-stimulated endothelial cells in an atherosclerosis-related in vitro model. Its overexpression protects HUVECs by sponging miR-338-3p to increase SIRT6, thereby reducing inflammation, oxidative stress, and apoptosis while improving cell viability."	0.7328
36737402	Thoracic cancer	2023	Circ_0003340 regulates the expression of ENAH to affect the development of esophageal cancer through miR-874-3p.	hsa_circ_0003340	circ_0003340 / Circ_OGDH	hsa_circ_OGDH	OGDH	Esophageal cancer / EC	MONDO:0007576	esophageal cancer	up-regulated	RT-qPCR	"circ_0003340 is upregulated in esophageal cancer and mainly localizes to the cytoplasm. It promotes malignant phenotypes (proliferation, migration/invasion, glycolysis and tumor growth) and suppresses apoptosis by sponging miR-874-3p to increase ENAH expression."	0.7855
36740679	Journal of translational medicine	2023	Circular RNA 0001789 sponges miR-140-3p and regulates PAK2 to promote the progression of gastric cancer.	hsa_circ_0001789	circ_0001789 / Circular RNA 0001789	hsa_circ_RAB11FIP1	RAB11FIP1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circ_0001789 is up-regulated in gastric cancer tissues, cells, and serum exosomes and correlates with metastasis and poor overall survival. It promotes malignant phenotypes (proliferation, migration/invasion, EMT, angiogenesis, tumorigenesis/metastasis) largely by sponging miR-140-3p to upregulate PAK2."	0.8823
36740902	"Cell cycle (Georgetown, Tex.)"	2023	Hsa_circ_0063329 inhibits prostate cancer growth and metastasis by modulating the miR-605-5p/tgif2 axis.	hsa_circ_0063329	circ_0063329 / circDDX17	hsa_circ_DDX17	DDX17	prostate cancer / PCa	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; ISH; Microarray	"hsa_circ_0063329 is down-regulated in prostate cancer and functions as a tumor suppressor by inhibiting proliferation, migration, and in vivo tumor growth. It mainly localizes to the cytoplasm and sponges miR-605-5p, thereby upregulating TGIF2 and suppressing TGF-beta/SMAD signaling."	0.8671
36741009	Frontiers in oncology	2023	ncRNAs mediated RPS6KA2 inhibits ovarian cancer proliferation via p38/MAPK signaling pathway.		circFAM169A	hsa_circ_FAM169A	FAM169A	ovarian cancer / OC	MONDO:0008170	ovarian cancer	unknown	RT-qPCR	"circFAM169A suppresses ovarian cancer cell proliferation by acting as a cytoplasmic ceRNA that sponges miR-106a-5p and miR-519d-3p, thereby increasing RPS6KA2 expression and affecting p38/MAPK signaling."	0.7094
36741263	Journal of Cancer	2023	Identification of a CircRNA-miRNA-mRNA Network and Integrated Analysis of Immune Infiltration in Oral Squamous Cell Carcinoma.		hsa_circ_000139			Oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	Microarray	"hsa_circ_000139 was identified bioinformatically as an up-regulated circRNA in OSCC and included in a ceRNA network. It was predicted to target hsa-let-7c, potentially influencing the hsa-let-7c target gene SLC20A1 within the constructed circRNA_miRNA_mRNA framework."	0.1768
36741263	Journal of Cancer	2023	Identification of a CircRNA-miRNA-mRNA Network and Integrated Analysis of Immune Infiltration in Oral Squamous Cell Carcinoma.		hsa_circ_001943			Oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	Microarray	"hsa_circ_001943 was bioinformatically identified as up-regulated in OSCC and incorporated into the study¡¯s ceRNA network. It was predicted to target hsa-let-7c, thereby potentially contributing to downstream regulation of the hsa-let-7c target SLC20A1."	0.1768
36741263	Journal of Cancer	2023	Identification of a CircRNA-miRNA-mRNA Network and Integrated Analysis of Immune Infiltration in Oral Squamous Cell Carcinoma.		hsa_circ_001536			Oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	Microarray	"hsa_circ_001536 was identified by microarray-based differential analysis as up-regulated in OSCC and included in the ceRNA network. It was predicted to target hsa-let-7c, which in the network targets SLC20A1."	0.1768
36741263	Journal of Cancer	2023	Identification of a CircRNA-miRNA-mRNA Network and Integrated Analysis of Immune Infiltration in Oral Squamous Cell Carcinoma.		hsa_circ_000859			Oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	Microarray	hsa_circ_000859 was identified as up-regulated in OSCC based on microarray analysis and included among circRNAs predicted to target hsa-let-7c in the ceRNA network. Its role was inferred within the predicted circRNA_hsa-let-7c_SLC20A1 regulatory framework.	0.1768
36741263	Journal of Cancer	2023	Identification of a CircRNA-miRNA-mRNA Network and Integrated Analysis of Immune Infiltration in Oral Squamous Cell Carcinoma.		hsa_circ_000226			Oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	Microarray	hsa_circ_000226 was identified as up-regulated in OSCC by microarray-based screening and included in the predicted ceRNA network as a circRNA targeting hsa-let-7c. Its proposed role is within the predicted circRNA_let-7c_SLC20A1 axis.	0.1768
36741263	Journal of Cancer	2023	Identification of a CircRNA-miRNA-mRNA Network and Integrated Analysis of Immune Infiltration in Oral Squamous Cell Carcinoma.		hsa_circ_001033			Oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	Microarray	hsa_circ_001033 was identified as up-regulated in OSCC by microarray-based screening and included in the ceRNA network as a predicted regulator of hsa-let-7c. Its functional implication is limited to predicted ceRNA relationships (no experimental validation reported).	0.1768
36747239	Journal of experimental & clinical cancer research : CR	2023	HNRNPL induced circFAM13B increased bladder cancer immunotherapy sensitivity via inhibiting glycolysis through IGF2BP1/PKM2 pathway.	hsa_circ_0001535	circFAM13B	hsa_circ_FAM13B	FAM13B	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"circFAM13B is down-regulated in bladder cancer and acts as a tumor-suppressive circRNA that enhances anti-PD-1 immunotherapy sensitivity. It binds IGF2BP1 to reduce PKM2 mRNA stability, inhibiting glycolysis and the acidic tumor microenvironment, thereby promoting CD8+ T cell function."	0.8928
36747292	Experimental hematology & oncology	2023	Hypoxia-associated circPRDM4 promotes immune escape via HIF-1alpha regulation of PD-L1 in hepatocellular carcinoma.	hsa_circ_0007468	circPRDM4	hsa_circ_PRDM4	PRDM4	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"In HCC under hypoxia, circPRDM4 promotes immune escape by increasing PD-L1 (CD274) transcription and reducing CD8+ T cell infiltration/cytotoxicity. Mechanistically, it functions in the nucleus as a scaffold that recruits HIF-1alpha to the CD274 promoter to enhance HIF-1alpha-mediated transactivation. Clinically, higher circPRDM4 is enriched in PD-1 blockade responders and associates with longer PFS/OS."	0.8966
36754085	Thoracic cancer	2023	Hsa_circ_0001925 promotes malignant progression in triple-negative breast cancer via miR-1299/YY1 axis.	hsa_circ_0001925		hsa_circ_KIF4A	KIF4A	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"hsa_circ_0001925 is upregulated in TNBC tissues and cell lines and mainly localizes to the cytoplasm. It promotes TNBC malignant phenotypes (proliferation, migration, angiogenesis and tumor growth) and inhibits apoptosis by sponging miR-1299 to upregulate YY1."	0.8327
36755291	BMC medical genomics	2023	FZD1/KLF10-hsa-miR-4762-5p/miR-224-3p-circular RNAs axis as prognostic biomarkers and therapeutic targets for glioblastoma: a comprehensive report.	hsa_circ_0016956	circ_0016956			glioblastoma / GBM	MONDO:0018177	glioblastoma	dysregulated	Microarray	circ_0016956 was identified via GEO/TCGA bioinformatics as a differentially expressed circRNA included in a GBM ceRNA network and in a survival-related subnetwork linked to overall survival.	0.348
36755291	BMC medical genomics	2023	FZD1/KLF10-hsa-miR-4762-5p/miR-224-3p-circular RNAs axis as prognostic biomarkers and therapeutic targets for glioblastoma: a comprehensive report.	hsa_circ_0006841	circ_0006841			glioblastoma / GBM	MONDO:0018177	glioblastoma	dysregulated	Microarray	circ_0006841 was bioinformatically identified as a differentially expressed circRNA in GBM and included in a survival-related circRNA_miRNA_mRNA regulatory subnetwork associated with overall survival.	0.348
36755291	BMC medical genomics	2023	FZD1/KLF10-hsa-miR-4762-5p/miR-224-3p-circular RNAs axis as prognostic biomarkers and therapeutic targets for glioblastoma: a comprehensive report.	hsa_circ_0006635	circ_0006635			glioblastoma / GBM	MONDO:0018177	glioblastoma	dysregulated	Microarray	circ_0006635 was identified through GEO/TCGA bioinformatics as a dysregulated circRNA in GBM and included in a prognostic ceRNA subnetwork associated with overall survival.	0.348
36755291	BMC medical genomics	2023	FZD1/KLF10-hsa-miR-4762-5p/miR-224-3p-circular RNAs axis as prognostic biomarkers and therapeutic targets for glioblastoma: a comprehensive report.	hsa_circ_0056281	circ_0056281			glioblastoma / GBM	MONDO:0018177	glioblastoma	dysregulated	Microarray	circ_0056281 emerged from multi-dataset differential-expression screening and was included in a GBM prognostic ceRNA subnetwork associated with overall survival; no experimental validation was performed.	0.348
36755291	BMC medical genomics	2023	FZD1/KLF10-hsa-miR-4762-5p/miR-224-3p-circular RNAs axis as prognostic biomarkers and therapeutic targets for glioblastoma: a comprehensive report.	hsa_circ_0005223	circ_0005223			glioblastoma / GBM	MONDO:0018177	glioblastoma	dysregulated	Microarray	circ_0005223 was computationally identified as dysregulated in GBM and included in the final survival subnetwork of the constructed ceRNA network; the paper does not report experimental validation for this circRNA.	0.348
36755291	BMC medical genomics	2023	FZD1/KLF10-hsa-miR-4762-5p/miR-224-3p-circular RNAs axis as prognostic biomarkers and therapeutic targets for glioblastoma: a comprehensive report.	hsa_circ_0005777	circ_0005777			glioblastoma / GBM	MONDO:0018177	glioblastoma	dysregulated	Microarray	circ_0005777 was identified by integrated GEO/TCGA bioinformatics and included among the survival-associated circRNAs in the constructed GBM ceRNA network; no expression direction or lab validation was reported for this specific circRNA.	0.348
36759861	Journal of neuroinflammation	2023	"The brain reacting to COVID-19: analysis of the cerebrospinal fluid proteome, RNA and inflammation."		circ_00022_SMC1A	hsa_circ_SMC1A	SMC1A	COVID-19 / coronavirus disease 2019	MONDO:0100096	COVID-19	down-regulated	RNA-seq	circ_00022_SMC1A (host gene SMC1A) is significantly down-regulated in CSF from COVID-19 patients compared with controls based on CSF RNA-seq differential expression analysis; no mechanism or functional role was investigated.	0.1768
36759861	Journal of neuroinflammation	2023	"The brain reacting to COVID-19: analysis of the cerebrospinal fluid proteome, RNA and inflammation."		circ_00007_MAN1A2	hsa_circ_MAN1A2	MAN1A2	COVID-19 / coronavirus disease 2019	MONDO:0100096	COVID-19	down-regulated	RNA-seq	circ_00007_MAN1A2 (host gene MAN1A2) is significantly down-regulated in CSF from COVID-19 patients compared with controls based on CSF RNA-seq differential expression analysis; no mechanism or functional role was investigated.	0.1768
36760352	Oxidative medicine and cellular longevity	2023	circ_0001274 Competitively Binds miR-143-3p to Upregulate VWF Expression to Improve Acute Traumatic Coagulopathy.	hsa_circ_0001274	circ_0001274			traumatic coagulopathy	MONDO:0001531	blood coagulation disease	down-regulated	RT-qPCR; RNA-seq	"circ_0001274 is down-regulated in peripheral blood of ATC patients and ATC mice. It acts as a ceRNA that sponges miR-143-3p, thereby increasing VWF expression and improving coagulation function in ATC models."	0.7546
36760719	"Open medicine (Warsaw, Poland)"	2023	Propofol-mediated circ_0000735 downregulation restrains tumor growth by decreasing integrin-beta1 expression in non-small cell lung cancer.	hsa_circ_0000735	circ_0000735	hsa_circ_P2RX1	P2RX1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0000735 is up-regulated in NSCLC and promotes malignant phenotypes (viability/proliferation/invasion) while inhibiting apoptosis. It mainly functions as a ceRNA by sponging miR-153-3p to increase ITGB1 expression, and propofol suppresses NSCLC growth partly by downregulating circ_0000735 and thereby reducing ITGB1 via the circ_0000735/miR-153-3p axis."	0.8174
36760722	"Open medicine (Warsaw, Poland)"	2023	Silencing of circ_002136 sensitizes gastric cancer to paclitaxel by targeting the miR-16-5p/HMGA1 axis.	hsa_circ_0000005	circ_002136 / hsa_circCDK11A_001	hsa_circ_CDK11A	CDK11A	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_002136 (hsa_circ_002136) is upregulated in gastric cancer, especially in paclitaxel-resistant tissues/cells. It promotes paclitaxel resistance and invasive behaviors by sponging miR-16-5p to derepress HMGA1; silencing circ_002136 increases paclitaxel sensitivity, inhibits migration/invasion, and induces apoptosis in vitro and suppresses xenograft growth in vivo."	0.8442
36769461	Journal of clinical medicine	2023	The Differential Expression of Circular RNAs and the Role of circAFF1 in Lens Epithelial Cells of High-Myopic Cataract.	hsa_circ_0070386	circAFF1	hsa_circ_AFF1	AFF1	high-myopic cataract / HMC	MONDO:0004495	myotonic cataract	up-regulated	RT-qPCR; RNA-seq	"circAFF1 is up-regulated in lens epithelium from HMC patients compared with ARC. In lens epithelial cells, circAFF1 localizes to the cytoplasm and promotes proliferation and migration while inhibiting apoptosis, at least partly by sponging miR-760 to upregulate TPM1."	0.6744
36769461	Journal of clinical medicine	2023	The Differential Expression of Circular RNAs and the Role of circAFF1 in Lens Epithelial Cells of High-Myopic Cataract.	hsa_circ_0025830	circDENND5B	hsa_circ_DENND5B	DENND5B	high-myopic cataract / HMC	MONDO:0004495	myotonic cataract	down-regulated	RT-qPCR; RNA-seq	circDENND5B is significantly down-regulated in HMC lens epithelium compared with ARC based on RNA-seq and qPCR validation; no downstream functional mechanism was experimentally characterized in this paper.	0.3588
36769461	Journal of clinical medicine	2023	The Differential Expression of Circular RNAs and the Role of circAFF1 in Lens Epithelial Cells of High-Myopic Cataract.	hsa_circ_0000462	circSLC15A4	hsa_circ_SLC15A4	SLC15A4	high-myopic cataract / HMC	MONDO:0004495	myotonic cataract	up-regulated	RT-qPCR; RNA-seq	circSLC15A4 is up-regulated in HMC lens epithelium compared with ARC based on RNA-seq and qPCR validation; no direct functional assays were performed for circSLC15A4 in this study.	0.3588
36769461	Journal of clinical medicine	2023	The Differential Expression of Circular RNAs and the Role of circAFF1 in Lens Epithelial Cells of High-Myopic Cataract.	hsa_circ_0035249	circTRPM7	hsa_circ_TRPM7	TRPM7	high-myopic cataract / HMC	MONDO:0004495	myotonic cataract	down-regulated	RNA-seq	"circTRPM7 was identified by sequencing as significantly down-regulated in HMC versus ARC lens epithelium, but this paper did not report qPCR confirmation or functional/mechanistic experiments for circTRPM7."	0.1155
36770940	"Molecules (Basel, Switzerland)"	2023	Identification of a Novel Angiogenesis Signalling circSCRG1/miR-1268b/NR4A1 Pathway in Atherosclerosis and the Regulatory Effects of TMP-PF In Vitro.		circSCRG1 / circRNA_06206	hsa_circ_SCRG1	SCRG1	atherosclerosis / AS	MONDO:0005311	atherosclerosis	down-regulated	RT-qPCR; RNA-seq	"circSCRG1 (derived from SCRG1) is down-regulated under ox-LDL stimulation in HUVECs and functions as an anti-angiogenic regulator in an in vitro atherosclerosis-related angiogenesis model. Mechanistically, it interacts with miR-1268b and modulates NR4A1, forming the circSCRG1/miR-1268b/NR4A1 axis; TMP-PF up-regulates circSCRG1 and suppresses ox-LDL-induced angiogenesis via this axis."	0.7519
36774884	Translational oncology	2023	Circular RNA circFBXO7 attenuates non-small cell lung cancer tumorigenesis by sponging miR-296-3p to facilitate KLF15-mediated transcriptional activation of CDKN1A.	hsa_circ_0008832	circFBXO7	hsa_circ_FBXO7	FBXO7	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	"In NSCLC, circFBXO7 is down-regulated and functions as a tumor suppressor. It sponges miR-296-3p to increase KLF15, which transcriptionally activates CDKN1A, leading to G1/S arrest and reduced tumor cell proliferation and xenograft growth."	0.8854
36774884	Translational oncology	2023	Circular RNA circFBXO7 attenuates non-small cell lung cancer tumorigenesis by sponging miR-296-3p to facilitate KLF15-mediated transcriptional activation of CDKN1A.		circFbxo7	mmu_circ_Fbxo7	Fbxo7	lung cancer	MONDO:0008903	lung cancer	unknown	RT-qPCR	"In a mouse lung cancer (LLC) syngeneic model, circFbxo7 overexpression suppresses tumor growth and is mainly localized in the cytoplasm. The downstream molecular mechanism was not further characterized."	0.6054
36776924	Disease markers	2023	Circular RNA circFAT1(e2) Facilitates Cell Progression through the miR-30e-5P/MYBL2 Pathway in Glioma.	hsa_circ_0001461		hsa_circ_FAT1	FAT1	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circFAT1(e2) is up-regulated in glioma cell lines and promotes proliferation, migration, and invasion. It functions through a ceRNA mechanism by sponging miR-30e-5p, thereby increasing MYBL2 expression and facilitating glioma progression."	0.5416
36777878	Current genomics	2022	Construction of PARPi Resistance-related Competing Endogenous RNA Network.		5:83537007|83555038			ovarian cancer / OC	MONDO:0008170	ovarian cancer	unknown	RNA-seq	This study identified 5:83537007|83555038 as a hub circRNA in a predicted circRNA-miRNA-mRNA ceRNA network in Olaparib-induced PARPi-resistant ovarian cancer cells. It is computationally predicted to regulate miR-320b and thereby influence expression of miR-320b target genes linked to resistance-related processes.	0.1768
36777878	Current genomics	2022	Construction of PARPi Resistance-related Competing Endogenous RNA Network.		14:61970132|61996542			ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RNA-seq	"This study identified 14:61970132|61996542 as an upregulated, high-degree (hub) circRNA in Olaparib-induced PARPi-resistant ovarian cancer SKOV3 cells using RNA-seq and computational ceRNA network analysis. Its role is proposed within a circRNA-miRNA-mRNA ceRNA regulatory framework, but no experimental validation or specific downstream miRNA/mRNA axis was reported for this circRNA."	0.1768
36778920	Journal of oncology	2023	The Effects of circ_000558/miR-1225-5p/ARL4C on Regulating the Proliferation of Renal Cell Carcinoma Cells.	hsa_circ_0000558	circ_000558 / hsa_circEIF4G3_054	hsa_circ_EIF4G3	EIF4G3	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR; Microarray	"circ_000558 is up-regulated in RCC and mainly localized in the cytoplasm. It promotes RCC cell proliferation and suppresses apoptosis by sponging miR-1225-5p, thereby increasing ARL4C expression and enhancing tumor growth in a xenograft model."	0.6867
36781839	Cell death & disease	2023	m6A-modified circRNA MYO1C participates in the tumor immune surveillance of pancreatic ductal adenocarcinoma through m6A/PD-L1 manner.	hsa_circ_0041234	circMYO1C / hsa_circRNA_101936	hsa_circ_MYO1C	MYO1C	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circMYO1C (hsa_circ_0041234), derived from MYO1C, is up-regulated in PDAC and mainly localized in the cytoplasm. It promotes PDAC cell proliferation/migration and tumor growth in vivo by forming an RNA-protein complex with IGF2BP2 to bind and stabilize m6A-modified PD-L1 mRNA, contributing to immune escape; its circularization is induced by METTL3 via m6A-modified flanking introns."	0.8377
36792585	Cell death discovery	2023	The malignancy of chordomas is enhanced via a circTLK1/miR-16-5p/Smad3 positive feedback axis.	hsa_circ_0057021	circTLK1	hsa_circ_TLK1	TLK1	chordoma	MONDO:0008978	chordoma	up-regulated	RT-qPCR	"circTLK1 is up-regulated in chordoma tissues and cell lines and promotes malignant phenotypes (proliferation, migration/invasion and EMT) and xenograft tumor growth. Mechanistically, it sponges miR-16-5p in an AGO2-associated complex to increase Smad3, and Smad3 in turn transcriptionally activates TLK1/circTLK1, forming a positive feedback loop."	0.8968
36793126	Journal of experimental & clinical cancer research : CR	2023	Exosomal circTUBGCP4 promotes vascular endothelial cell tipping and colorectal cancer metastasis by activating Akt signaling pathway.		circTUBGCP4 / circ101501	hsa_circ_TUBGCP4	TUBGCP4	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; Microarray	"In CRC, exosomal circTUBGCP4 is up-regulated in metastatic settings and is transferred to endothelial cells, where it promotes migration, tube formation, and tip cell formation, thereby enhancing angiogenesis and metastasis. Mechanistically, it functions as a ceRNA to sponge miR-146b-3p, upregulate PDK2, and activate Akt signaling."	0.8794
36795937	Alzheimer's & dementia : the journal of the Alzheimer's Association	2023	Identification of circRNAs linked to Alzheimer's disease and related dementias.	hsa_circ_0108513	circKATNAL2	hsa_circ_KATNAL2	KATNAL2	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR	"circKATNAL2 is significantly down-regulated in AD cortex and hippocampus in independent clinical samples validated by RT-qPCR, indicating an AD-associated decrease in this circRNA in brain tissue."	0.429
36795937	Alzheimer's & dementia : the journal of the Alzheimer's Association	2023	Identification of circRNAs linked to Alzheimer's disease and related dementias.	hsa_circ_0127664	circKCNN2	hsa_circ_KCNN2	KCNN2	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR	"circKCNN2 is down-regulated in AD (validated by RT-qPCR in cortex, with a trend decrease in hippocampus) and its expression correlates with Braak (tau) pathology."	0.429
36795937	Alzheimer's & dementia : the journal of the Alzheimer's Association	2023	Identification of circRNAs linked to Alzheimer's disease and related dementias.	hsa_circ_0078784	circPSMB1	hsa_circ_PSMB1	PSMB1	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR	circPSMB1 is down-regulated in AD (validated by RT-qPCR in cortex with a trend decrease in hippocampus) and is associated with dementia severity (CDR) and tau pathology (Braak).	0.429
36795937	Alzheimer's & dementia : the journal of the Alzheimer's Association	2023	Identification of circRNAs linked to Alzheimer's disease and related dementias.	hsa_circ_0001566	circMAPK9	hsa_circ_MAPK9	MAPK9	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR	"circMAPK9 is decreased in AD (validated by RT-qPCR in cortex with a trend decrease in hippocampus) and is reduced by oligomeric tau in human NPCs; notably, its tau-induced downregulation occurs without a decrease in linear MAPK9 mRNA, suggesting circRNA-specific regulation."	0.429
36795937	Alzheimer's & dementia : the journal of the Alzheimer's Association	2023	Identification of circRNAs linked to Alzheimer's disease and related dementias.	hsa_circ_0132250	circRIMS1	hsa_circ_RIMS1	RIMS1	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR	"circRIMS1 is down-regulated in AD by RNA-seq meta-analysis and shows significant, qPCR-validated changes in cortex; it is also decreased by oligomeric tau treatment in human NPCs, suggesting sensitivity to AD-linked tau stress."	0.429
36795937	Alzheimer's & dementia : the journal of the Alzheimer's Association	2023	Identification of circRNAs linked to Alzheimer's disease and related dementias.	hsa_circ_0001681	circRAPGEF5	hsa_circ_RAPGEF5	RAPGEF5	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR	circRAPGEF5 is down-regulated in AD by RNA-seq meta-analysis and shows qPCR-validated changes in cortex; it is also decreased after oligomeric tau exposure in human NPCs.	0.429
36795937	Alzheimer's & dementia : the journal of the Alzheimer's Association	2023	Identification of circRNAs linked to Alzheimer's disease and related dementias.	hsa_circ_0006916	circHOMER1	hsa_circ_HOMER1	HOMER1	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR; RNA-seq	circHOMER1 is consistently down-regulated in AD across cortex and hippocampus RNA-seq datasets and shows qPCR-validated disease-linked differences in cortex; its levels are associated with dementia severity (CDR) and tau pathology (Braak).	0.4773
36795937	Alzheimer's & dementia : the journal of the Alzheimer's Association	2023	Identification of circRNAs linked to Alzheimer's disease and related dementias.	hsa_circ_0020093	circATRNL1	hsa_circ_ATRNL1	ATRNL1	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR	circATRNL1 is down-regulated in AD and shows qPCR-validated cortical changes; it correlates with multiple AD pathological traits and is decreased by oligomeric tau in human NPCs.	0.429
36795937	Alzheimer's & dementia : the journal of the Alzheimer's Association	2023	Identification of circRNAs linked to Alzheimer's disease and related dementias.	hsa_circ_0008433	circPDE4B	hsa_circ_PDE4B	PDE4B	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR	circPDE4B is down-regulated in AD by RNA-seq meta-analysis and shows qPCR-validated cortical changes; it is also decreased by oligomeric tau exposure in human NPCs.	0.429
36795937	Alzheimer's & dementia : the journal of the Alzheimer's Association	2023	Identification of circRNAs linked to Alzheimer's disease and related dementias.	hsa_circ_0003038	circAPP	hsa_circ_APP	APP	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR; RNA-seq	"circAPP is down-regulated in AD cortex (RNA-seq and RT-qPCR validated) and is decreased by oligomeric tau in human NPCs. The study supports a circAPP_miR-15-5p_mRNA regulatory relationship, with decreased IGF1 and SNAP25 observed in NPCs consistent with ceRNA-style regulation."	0.5618
36795937	Alzheimer's & dementia : the journal of the Alzheimer's Association	2023	Identification of circRNAs linked to Alzheimer's disease and related dementias.	hsa_circ_0003848	circPSEN1	hsa_circ_PSEN1	PSEN1	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR; RNA-seq	"circPSEN1 is up-regulated in AD cortex (RNA-seq and qPCR support, dependent on normalization control) and is associated with amyloid plaque pathology and cortex-restricted expression. The study proposes a circPSEN1_miR-137_mRNA regulatory network and shows that oligomeric tau decreases circPSEN1 in human NPCs, indicating stress responsiveness."	0.5618
36795937	Alzheimer's & dementia : the journal of the Alzheimer's Association	2023	Identification of circRNAs linked to Alzheimer's disease and related dementias.		circSLC8A1	hsa_circ_SLC8A1	SLC8A1	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR; RNA-seq	circSLC8A1 is down-regulated in AD cortex (RNA-seq and RT-qPCR). The study suggests a circSLC8A1_miR-7-5p_mRNA network in which reduced circSLC8A1 may increase miR-7-5p availability and decrease miR-7-5p target transcripts.	0.4773
36797317	Scientific reports	2023	Hsa_circ_0128846 knockdown attenuates the progression of pancreatic cancer by targeting miR-1270/NR3C1 axis.	hsa_circ_0128846	circ_0128846	hsa_circ_ZFR	ZFR	pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"circ_0128846 is up-regulated in pancreatic cancer tissues and cell lines and mainly localized in the cytoplasm. Its knockdown suppresses proliferation, colony formation and migration while promoting apoptosis, and inhibits xenograft tumor growth, partly by sponging miR-1270 to relieve repression of NR3C1."	0.7827
36797769	Journal of experimental & clinical cancer research : CR	2023	Targeting tumor exosomal circular RNA cSERPINE2 suppresses breast cancer progression by modulating MALT1-NF-__B-IL-6 axis of tumor-associated macrophages.	hsa_circ_0001103	cSERPINE2	hsa_circ_SERPINE2	SERPINE2	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	"cSERPINE2 (hsa_circ_0001103) is upregulated in breast cancer and predicts poor prognosis. It is packaged into tumor exosomes and transferred to TAMs, where it sponges miR-513a-5p to increase MALT1, activating NF-kappaB and boosting IL-6 secretion. TAM-derived IL-6 activates JAK2/STAT3 in tumor cells to raise EIF4A3 and CCL2, enhancing cSERPINE2 biogenesis and TAM recruitment in a positive feedback loop."	0.8837
36803376	Journal of neuroinflammation	2023	Circular RNA METTL9 contributes to neuroinflammation following traumatic brain injury by complexing with astrocytic SND1.		Circular RNA METTL9 / circMETTL9	rno_circ_METTL9	METTL9	traumatic brain injury / TBI	MONDO:0858950	traumatic brain injury	up-regulated	RT-qPCR; ISH; RNA-seq	"In rat TBI cortex, circMETTL9 is upregulated (peaking at day 7), enriched in astrocytes and mainly cytoplasmic. It binds the RBP SND1 and increases SND1 expression, thereby elevating multiple pro-inflammatory chemokines (e.g., CCL2, CXCL1, CCL3, CXCL3, CXCL10) to promote neuroinflammation, neurodegeneration, apoptosis, and neurological dysfunction; circMETTL9 knockdown ameliorates these outcomes."	0.7639
36803446	European journal of medical research	2023	Pro-fibrotic and apoptotic activities of circARAP1 in myocardial ischemia-reperfusion injury.	hsa_circ_0023461	hsa_circ_0023461 / circARPA1	hsa_circ_ARAP1	ARAP1	myocardial ischemia/reperfusion injury	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR	"circARAP1 is up-regulated in MI/RI (and H/R-treated cardiomyocytes) and promotes cardiomyocyte fibrosis and apoptosis. Mechanistically, it sponges miR-379-5p to upregulate KLF9 and activate Wnt/beta-catenin signaling, thereby aggravating MI/RI injury in vitro and in a mouse MI/RI model."	0.8491
36803975	Cellular & molecular biology letters	2023	Exosomal circ_0026611 contributes to lymphangiogenesis by reducing PROX1 acetylation and ubiquitination in human lymphatic endothelial cells (HLECs).	hsa_circ_0026611	circ_0026611			esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"In ESCC cell-derived exosomes, circ_0026611 is up-regulated and promotes HLEC migration/invasion and lymphangiogenesis. Mechanistically, circ_0026611 binds NAA10 to inhibit NAA10-mediated PROX1 acetylation and subsequent ubiquitination/degradation, increasing PROX1 protein and indirectly enhancing VEGFR3 transcription."	0.6649
36806251	Communications biology	2023	CircFNDC3B regulates osteoarthritis and oxidative stress by targeting miR-525-5p/HO-1 axis.	hsa_circ_0001361	circFNDC3B	hsa_circ_FNDC3B	FNDC3B	Osteoarthritis / OA	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR; RNA-seq	"In osteoarthritis, circFNDC3B (hsa_circ_0001361) is down-regulated in human OA cartilage and IL-1beta-induced chondrocytes. It mainly localizes to the cytoplasm and acts as a ceRNA by sponging miR-525-5p to de-repress HO-1, thereby reducing ROS and inhibiting NF-kappaB activation, protecting ECM (Collagen II/Aggrecan) and promoting chondrocyte proliferation; its overexpression alleviates OA in an ACLT rabbit model."	0.8679
36806670	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2023	Hypoxia-Induced FUS-circTBC1D14 Stress Granules Promote Autophagy in TNBC.		circTBC1D14 / hsa_circRNA_103598	hsa_circ_TBC1D14	TBC1D14	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"circTBC1D14 is up-regulated in TNBC and promotes tumor growth and metastasis, particularly under hypoxia. Mechanistically, it forms hypoxia-induced stress granules with FUS and promotes lysosome-associated autophagy by recruiting LAMP1, while stabilizing PRMT1 via inhibition of K48-linked polyubiquitination and enhancing hypoxia signaling through the VHL/HIF-1alpha axis."	0.8856
36808302	Discover oncology	2023	Circ_0000182 promotes cholesterol synthesis and proliferation of stomach adenocarcinoma cells by targeting miR-579-3p/SQLE axis.	hsa_circ_0000182	circ_0000182	hsa_circ_FLVCR1	FLVCR1	stomach adenocarcinoma / STAD	MONDO:0005036	gastric adenocarcinoma	up-regulated	RT-qPCR	"circ_0000182 is up-regulated in stomach adenocarcinoma tissues/cell lines and promotes STAD cell proliferation and cholesterol synthesis. Mechanistically, it functions as a cytoplasmic ceRNA that sponges miR-579-3p to increase SQLE expression, and its high expression correlates with larger tumor size."	0.778
36811283	Thoracic cancer	2023	Circ_0001667 accelerates breast cancer proliferation and angiogenesis through regulating CXCL10 expression by sponging miR-6838-5p.	hsa_circ_0001667	circ_0001667	hsa_circ_HEATR2	HEATR2	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0001667 is up-regulated in breast cancer tissues and cell lines and promotes proliferation and angiogenesis. Mechanistically, it functions as a ceRNA by sponging miR-6838-5p, thereby relieving repression of CXCL10 and enhancing malignant phenotypes, including tumor growth in vivo."	0.7631
36811957	Cancer research	2023	circFNDC3B Accelerates Vasculature Formation and Metastasis in Oral Squamous Cell Carcinoma.	hsa_circ_0001361	circFNDC3B	hsa_circ_FNDC3B	FNDC3B	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	circFNDC3B is up-regulated in OSCC and correlates with LN metastasis and poor RFS. It promotes OSCC migration/invasion and enhances angiogenesis and lymphangiogenesis via a nuclear circFNDC3B_FUS/MDM2_HIF1A_VEGFA mechanism and a cytoplasmic ceRNA mechanism sponging miR-181c-5p to increase SERPINE1 and PROX1.	0.9033
36814305	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2023	circCIMT Silencing Promotes Cadmium-Induced Malignant Transformation of Lung Epithelial Cells Through the DNA Base Excision Repair Pathway.		novel_circ_004401 / circCIMT	hsa_circ_EZH2	EZH2	lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR; RNA-seq	"circCIMT (novel_circ_004401), derived from EZH2, is down-regulated after cadmium exposure and in lung cancer tissues. It binds APEX1 and supports the BER DNA repair program; circCIMT knockdown increases DNA damage and promotes Cd-induced malignant transformation, migration, and invasion of lung epithelial cells."	0.7224
36818340	Frontiers in cardiovascular medicine	2023	"circRNA, a novel diagnostic biomarker for coronary heart disease."	hsa_circ_0001785	circRNA0001785 / circ0001785			coronary heart disease / CHD	MONDO:0005010	coronary artery disorder	down-regulated	RT-qPCR; Microarray	"circRNA0001785 is down-regulated in peripheral blood/exosome-derived profiles of CHD patients and was validated by qRT-PCR. It is proposed to act as a ceRNA by binding miR513a-5p to relieve repression of TGFBR3, supporting its potential as a diagnostic biomarker for CHD."	0.5047
36818340	Frontiers in cardiovascular medicine	2023	"circRNA, a novel diagnostic biomarker for coronary heart disease."	hsa_circ_0000973	circRNA0000973			coronary heart disease / CHD	MONDO:0005010	coronary artery disorder	down-regulated	RT-qPCR; Microarray	"circRNA0000973 is down-regulated in CHD peripheral blood and was qRT-PCR validated. It is proposed to act as a ceRNA to regulate LFNG by competitively binding miR-330-3p and miR-548p, and shows diagnostic value by ROC analysis."	0.5047
36818340	Frontiers in cardiovascular medicine	2023	"circRNA, a novel diagnostic biomarker for coronary heart disease."	hsa_circ_0001741	circRNA0001741			coronary heart disease / CHD	MONDO:0005010	coronary artery disorder	down-regulated	RT-qPCR; Microarray	"circRNA0001741 is down-regulated in CHD peripheral blood and was validated by qRT-PCR. It is proposed to bind miR-548p and thereby increase LFNG expression in a ceRNA-like regulatory relationship, with moderate diagnostic performance in ROC analysis."	0.5047
36818340	Frontiers in cardiovascular medicine	2023	"circRNA, a novel diagnostic biomarker for coronary heart disease."	hsa_circ_0003922	circRNA0003922			coronary heart disease / CHD	MONDO:0005010	coronary artery disorder	down-regulated	RT-qPCR; Microarray	"circRNA0003922 is down-regulated in CHD and was supported by qRT-PCR validation. It is proposed to act through a ceRNA mechanism by competitively binding miR-513a-5p to increase TGFBR3 or LFNG expression, and shows relatively high diagnostic AUC in ROC analysis."	0.5047
36818340	Frontiers in cardiovascular medicine	2023	"circRNA, a novel diagnostic biomarker for coronary heart disease."	hsa_circ_0004383	circRNA0004383			coronary heart disease / CHD	MONDO:0005010	coronary artery disorder	down-regulated	RT-qPCR; Microarray	"circRNA0004383 is down-regulated in CHD peripheral blood and was validated by qRT-PCR. It has modest diagnostic value for CHD as assessed by ROC analysis (AUC 0.644), but no specific downstream mechanism was reported."	0.4679
36818340	Frontiers in cardiovascular medicine	2023	"circRNA, a novel diagnostic biomarker for coronary heart disease."	hsa_circ_0008488	circRNA0008488			coronary heart disease / CHD	MONDO:0005010	coronary artery disorder	unknown	RT-qPCR; Microarray	"circRNA0008488 was included among candidate biomarkers for CHD and underwent qRT-PCR verification, with diagnostic performance evaluated by ROC (AUC 0.618). The article does not clearly report its direction of differential expression or mechanism in CHD."	0.4679
36818567	Aging and disease	2023	Long RNA Profiles of Human Brain Extracellular Vesicles Provide New Insights into the Pathogenesis of Alzheimer's Disease.	hsa_circ_0087493				Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0087493 is a differentially expressed circRNA in extracellular vesicles isolated from post-mortem frontal cortex of Alzheimer¡¯s disease patients versus controls, and its RNA-seq expression change was validated by RT-qPCR. The study included this circRNA in circRNA_miRNA_mRNA ceRNA network construction, but did not report a specific miRNA/mRNA axis or dedicated functional assays for this individual circRNA."	0.3588
36818567	Aging and disease	2023	Long RNA Profiles of Human Brain Extracellular Vesicles Provide New Insights into the Pathogenesis of Alzheimer's Disease.	hsa_circ_0102923				Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0102923 is a differentially expressed circRNA in extracellular vesicles from post-mortem frontal cortex of Alzheimer¡¯s disease donors versus controls, with RNA-seq results validated by RT-qPCR. It was part of the study¡¯s circRNA_miRNA_mRNA ceRNA network analysis, but no specific downstream miRNA/mRNA targets or functional phenotypes were assigned to this circRNA individually."	0.3588
36818567	Aging and disease	2023	Long RNA Profiles of Human Brain Extracellular Vesicles Provide New Insights into the Pathogenesis of Alzheimer's Disease.	hsa_circ_0089902				Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0089902 is a differentially expressed extracellular-vesicle circRNA in post-mortem frontal cortex samples from Alzheimer¡¯s disease patients compared with controls, and its expression change detected by RNA-seq was validated by RT-qPCR. The paper used circRNA_miRNA_mRNA ceRNA network analysis at a global level, but did not provide a dedicated mechanistic axis or functional experiments for this specific circRNA."	0.3588
36819541	Annals of translational medicine	2023	Silencing hsa_circ_0049271 attenuates hypoxia-reoxygenation (H/R)-induced myocardial cell injury via the miR-17-3p/FZD4 signaling axis.	hsa_circ_0049271				acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR; Microarray	"hsa_circ_0049271 is up-regulated in AMI patient blood and in H/R-induced H9c2 cells. It mainly localizes to the cytoplasm and acts as a miR-17-3p sponge, relieving repression of FZD4. Functionally, circ_0049271 promotes cardiomyocyte injury by inhibiting proliferation and enhancing apoptosis, oxidative stress, and inflammatory responses, while its knockdown is protective."	0.7858
36820067	"Open medicine (Warsaw, Poland)"	2023	circ_0000376 knockdown suppresses non-small cell lung cancer cell tumor properties by the miR-545-3p/PDPK1 pathway.	hsa_circ_0000376	circ_0000376			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0000376 is up-regulated in NSCLC tissues and cell lines and promotes malignant phenotypes and glutamine metabolism. Mechanistically, it binds (sponges) miR-545-3p to increase PDPK1, and circ_0000376 knockdown suppresses xenograft tumor growth."	0.7892
36820560	Medicine	2023	Circ0005654 as a new biomarker of thyroid cancer interacting with SP1 to influence the prognosis: A case-control study.	hsa_circ_0005654	Circ0005654			thyroid cancer / TC	MONDO:0002108	thyroid cancer	up-regulated	RT-qPCR	"Circ0005654 is up-regulated in thyroid cancer tissues versus adjacent tissues and shows strong diagnostic performance by ROC analysis. Higher Circ0005654 expression is associated with worse 3-year survival and adverse clinicopathological features, and the study suggests its pro-tumor role may relate to Wnt/beta-catenin signaling and interaction with SP1."	0.4758
36823512	Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)	2023	Circ_0068631 sponges miR-139-5p to promote the growth and metastasis of cutaneous squamous cell carcinoma by upregulating HOXB7.	hsa_circ_0068631	hsa_circRNA_103557	hsa_circ_TFRC		cutaneous squamous cell carcinoma / CSCC	MONDO:0002529	skin squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ_0068631 is overexpressed in CSCC tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation, invasion/metastasis and EMT while inhibiting apoptosis, at least partly by sponging miR-139-5p to de-repress HOXB7, and it enhances tumor growth in a xenograft model."	0.786
36827049	Medicine	2023	Hsa_circ_0046430 promotes the progression of colorectal cancer by targeting miR-6785-5p/SRCIN1 axis as a ceRNA.	hsa_circ_0046430	circ_0046430			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0046430 is up-regulated in colorectal cancer tissues and is proposed to act as a ceRNA within the hsa_circ_0046430/miR-6785-5p/SRCIN1 axis. The axis was supported by microarray/bioinformatics analyses and validated by qRT-PCR in paired clinical tissues, suggesting relevance to CRC progression and prognosis."	0.4032
36831736	Brain sciences	2023	A Meaningful Strategy for Glioma Diagnosis via Independent Determination of hsa_circ_0004214.	hsa_circ_0004214	circ0004214 / CircAMOTL1	hsa_circ_AMOTL1	AMOTL1	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"hsa_circ_0004214 (host gene AMOTL1) is up-regulated in glioma tissues, especially in high-grade gliomas (WHO III/IV), and shows strong diagnostic performance by ROC analysis. Functionally, overexpression enhances and knockdown reduces U87 cell migration. A putative ceRNA/RBP interaction network involving miR-28-3p, miR-379-5p, miR-382-5p, and miR-370-3p was bioinformatically predicted but not fully validated."	0.717
36834591	International journal of molecular sciences	2023	FUS Alters circRNA Metabolism in Human Motor Neurons Carrying the ALS-Linked P525L Mutation.		circCARHSP1	hsa_circ_CARHSP1	CARHSP1	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR; RNA-seq	"circCARHSP1 is down-regulated in FUS P525L mutant human motor neurons and shows a cytoplasmic localization shift in the mutant condition. It is predicted to sponge miR-24-3p and miR-345-5p via binding sites at its back-splicing junction, potentially influencing downstream endo-lysosomal/autophagy-related targets."	0.413
36834591	International journal of molecular sciences	2023	FUS Alters circRNA Metabolism in Human Motor Neurons Carrying the ALS-Linked P525L Mutation.		circRHOBTB3	hsa_circ_RHOBTB3	RHOBTB3	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR; RNA-seq	"circRHOBTB3 is one of the circRNAs significantly downregulated in FUS P525L mutant human motor neurons, with changes not explained by concordant host linear RNA variation. No specific miRNA/mRNA mechanism was reported for this circRNA."	0.3693
36834591	International journal of molecular sciences	2023	FUS Alters circRNA Metabolism in Human Motor Neurons Carrying the ALS-Linked P525L Mutation.		circCORO1C	hsa_circ_CORO1C	CORO1C	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR; RNA-seq	"circCORO1C is significantly downregulated in FUS P525L mutant human motor neurons, with deregulation not mirrored by its linear counterpart. No specific downstream miRNA/mRNA axis was reported for this circRNA in this study."	0.3693
36834591	International journal of molecular sciences	2023	FUS Alters circRNA Metabolism in Human Motor Neurons Carrying the ALS-Linked P525L Mutation.		circZNF124	hsa_circ_ZNF124	ZNF124	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR; RNA-seq	"circZNF124 is a down-regulated circRNA in FUS P525L mutant human motor neurons and is predominantly nuclear in wild-type conditions. Its flanking introns show mutant FUS binding sites together with inverted Alu repeats, consistent with a proposed negative effect of mutant FUS on Alu-mediated circularization."	0.2799
36834591	International journal of molecular sciences	2023	FUS Alters circRNA Metabolism in Human Motor Neurons Carrying the ALS-Linked P525L Mutation.		circSMARCA5	hsa_circ_SMARCA5	SMARCA5	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR; RNA-seq	"circSMARCA5 is down-regulated in FUS P525L mutant human motor neurons and is predominantly nuclear. The study suggests a possible (not significant) shift in localization in mutant conditions, which may relate to its downregulation, but no specific downstream axis was established."	0.2263
36834591	International journal of molecular sciences	2023	FUS Alters circRNA Metabolism in Human Motor Neurons Carrying the ALS-Linked P525L Mutation.		circNAA35	hsa_circ_NAA35	NAA35	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR; RNA-seq	"circNAA35 is markedly down-regulated in FUS P525L mutant human motor neurons and exhibits a significant shift toward the cytoplasm in mutant cells. Its flanking introns contain mutant FUS binding sites and inverted Alu repeats, consistent with a model in which mutant FUS perturbs circRNA biogenesis and localization."	0.413
36834591	International journal of molecular sciences	2023	FUS Alters circRNA Metabolism in Human Motor Neurons Carrying the ALS-Linked P525L Mutation.		circPSME3	hsa_circ_PSME3	PSME3	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR; RNA-seq	"circPSME3 is down-regulated in FUS P525L mutant human motor neurons and undergoes a significant shift toward cytoplasmic localization in the mutant condition, indicating mutant FUS can affect circRNA partitioning in addition to expression levels."	0.3693
36834591	International journal of molecular sciences	2023	FUS Alters circRNA Metabolism in Human Motor Neurons Carrying the ALS-Linked P525L Mutation.		circSLC8A1	hsa_circ_SLC8A1	SLC8A1	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR; RNA-seq	"circSLC8A1 is down-regulated in FUS P525L mutant human motor neurons (with concordant downregulation of its linear counterpart) and is predicted to function as a miRNA sponge. It may bind miR-335-3p, miR-27a/b-3p and miR-30d-3p, potentially affecting ALS-relevant targets involved in neuroprotection, DNA repair, trafficking/axon guidance and synaptic transmission."	0.2799
36834591	International journal of molecular sciences	2023	FUS Alters circRNA Metabolism in Human Motor Neurons Carrying the ALS-Linked P525L Mutation.			hsa_circ_DLC1	DLC1	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR; RNA-seq	"circDLC1 is down-regulated in FUS P525L mutant human motor neurons and is part of a predicted cytoplasmic circRNA_miRNA_mRNA network. Experimental siRNA knockdown supports its sponge function for miR-217 by showing decreased ENAH mRNA, suggesting a circDLC1/miR-217/ENAH axis relevant to neuronal processes implicated in ALS."	0.4851
36838686	"Molecules (Basel, Switzerland)"	2023	Astaxanthin Alleviates Foam Cell Formation and Promotes Cholesterol Efflux in Ox-LDL-Induced RAW264.7 Cells via CircTPP2/miR-3073b-5p/ABCA1 Pathway.			mmu_circ_TPP2	TPP2	atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR; RNA-seq	"In ox-LDL-induced RAW264.7 foam cells, astaxanthin increases circTPP2 expression. circTPP2 suppresses miR-3073b-5p and elevates ABCA1, promoting cholesterol efflux and reducing lipid accumulation/foam cell formation."	0.6412
36838686	"Molecules (Basel, Switzerland)"	2023	Astaxanthin Alleviates Foam Cell Formation and Promotes Cholesterol Efflux in Ox-LDL-Induced RAW264.7 Cells via CircTPP2/miR-3073b-5p/ABCA1 Pathway.		circZfp710	mmu_circ_Zfp710	Zfp710	atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR; RNA-seq	"circZfp710 was identified by circRNA-seq and validated by RT-qPCR as significantly upregulated in AST-treated ox-LDL-induced RAW264.7 foam cells, but its downstream mechanism/function was not further established in this study."	0.329
36838686	"Molecules (Basel, Switzerland)"	2023	Astaxanthin Alleviates Foam Cell Formation and Promotes Cholesterol Efflux in Ox-LDL-Induced RAW264.7 Cells via CircTPP2/miR-3073b-5p/ABCA1 Pathway.		circSclt1	mmu_circ_Sclt1	Sclt1	atherosclerosis / AS	MONDO:0005311	atherosclerosis	down-regulated	RT-qPCR; RNA-seq	"circSclt1 was identified by circRNA-seq and validated by RT-qPCR as downregulated in AST-treated ox-LDL-induced RAW264.7 foam cells, but no specific downstream target or mechanism was established in this study."	0.329
36838686	"Molecules (Basel, Switzerland)"	2023	Astaxanthin Alleviates Foam Cell Formation and Promotes Cholesterol Efflux in Ox-LDL-Induced RAW264.7 Cells via CircTPP2/miR-3073b-5p/ABCA1 Pathway.		circRprd1b / mm10_circ_016411	mmu_circ_Rprd1b	Rprd1b	atherosclerosis / AS	MONDO:0005311	atherosclerosis	down-regulated	RT-qPCR; RNA-seq	"circRprd1b was identified by circRNA-seq and validated by RT-qPCR as downregulated in AST-treated ox-LDL-induced RAW264.7 foam cells, but no specific downstream target or mechanism was established in this study."	0.329
36840456	Cell journal	2023	The Evaluation of Vitamin E and TiO2 Nanoparticles Administration in Parkinson's Rat Model.	rno_circ_0001518	circRNA 0001518			Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	up-regulated	RT-qPCR	"In a 6-OHDA-induced Parkinson¡¯s disease rat model, circRNA 0001518 is up-regulated in brain (cerebral tissue). The authors suggest its increased expression may indicate a potential role in PD-induced cell death, while vitamin E/TiO2-NPs treatments did not significantly change its expression."	0.2586
36840946	Epigenetics	2023	CircDHRS3 inhibits prostate cancer cell proliferation and metastasis through the circDHRS3/miR-421/MEIS2 axis.	hsa_circ_0010023	circDHRS3	hsa_circ_DHRS3	DHRS3	prostate cancer / PCa	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; ISH; RNA-seq	"circDHRS3 is down-regulated in prostate cancer (especially high Gleason grade) and functions as a tumor suppressor. It sponges miR-421 in the cytoplasm to relieve repression of MEIS2, thereby inhibiting proliferation, migration/invasion, and lung/bone metastasis in vitro and in vivo."	0.8812
36841760	Cancer cell international	2023	"A novel circRNA, hsa_circ_0069382, regulates gastric cancer progression."	hsa_circ_0069382	hsa_circTBC1D19_011	hsa_circ_TBC1D19	TBC1D19	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0069382 is down-regulated in gastric cancer tissues/cell lines. Its overexpression suppresses gastric cancer cell proliferation, migration and invasion and reduces xenograft tumor growth, mainly by sponging miR-15a-5p to modulate the BTG2/FAK axis."	0.7897
36846202	Computational and mathematical methods in medicine	2023	Circular RNA_HIPK3-Targeting miR-93-5p Regulates KLF9 Expression Level to Control Acute Kidney Injury.		circHIPK3 / Circular RNA HIPK3	hsa_circ_HIPK3	HIPK3	acute kidney injury / AKI	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in renal I/R-induced AKI and in H/R-treated HK-2 cells. It aggravates renal tubular cell injury by sponging miR-93-5p to increase KLF9, thereby promoting inflammation, oxidative stress and apoptosis; circHIPK3 knockdown alleviates AKI in vitro and in vivo."	0.5637
36846202	Computational and mathematical methods in medicine	2023	Circular RNA_HIPK3-Targeting miR-93-5p Regulates KLF9 Expression Level to Control Acute Kidney Injury.		circHIPK3 / Circular RNA HIPK3	mmu_circ_HIPK3	HIPK3	acute kidney injury / AKI	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in renal I/R-induced AKI and in H/R-treated HK-2 cells. It aggravates renal tubular cell injury by sponging miR-93-5p to increase KLF9, thereby promoting inflammation, oxidative stress and apoptosis; circHIPK3 knockdown alleviates AKI in vitro and in vivo."	0.5637
36849569	Nature communications	2023	mcPGK1-dependent mitochondrial import of PGK1 promotes metabolic reprogramming and self-renewal of liver TICs.		mcPGK1	hsa_circ_CYTB	CYTB	liver cancer	MONDO:0002691	liver cancer	up-regulated	RT-qPCR; Northern Blot; ISH; RNA-seq	"mcPGK1 is up-regulated in liver TICs and liver tumors and promotes TIC self-renewal and tumor initiation/propagation. It binds PGK1 and TOM40/TOM70 to facilitate mitochondrial import of PGK1, activating the PGK1_PDK1_PDH axis to suppress OXPHOS and enhance glycolysis, leading to lactate/alpha-KG changes that promote Wnt/beta-catenin signaling."	0.89
36851875	Cancer science	2023	ALKBH5-induced circular RNA NRIP1 promotes glycolysis in thyroid cancer cells by targeting PKM2.	hsa_circ_0004771 	circNRIP1 / Circular RNA NRIP1	hsa_circ_NRIP1	NRIP1	papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"circNRIP1 is up-regulated in papillary thyroid cancer and mainly localizes to the cytoplasm. It promotes glycolysis and proliferation/tumor growth by sponging miR-541-5p and miR-3064-5p to increase PKM2 expression, and its expression/stability is regulated via ALKBH5-dependent m6A modification."	0.8375
36852074	Heliyon	2023	Hsa_circ_0072309 is a prognostic biomarker and is correlated with immune infiltration in gastric cancer.	hsa_circ_0072309	circ0072309			gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0072309 is down-regulated in gastric cancer tissues and cell lines and functions as a tumor-suppressive circRNA by inhibiting GC cell proliferation, migration and invasion in vitro. Mechanistically, it binds hsa-miR-34a-3p and hsa-miR-330-5p as a miRNA-interacting circRNA and is proposed as a biomarker related to lymph node metastasis."	0.7745
36854930	Cell proliferation	2023	Proangiogenic role of circRNA-007371 in liver fibrosis.		circRNA-007371	mmu_circ_Stag1	Stag1	liver fibrosis	MONDO:0005155	cirrhosis of liver	up-regulated	RT-qPCR; Microarray	"circRNA-007371 is up-regulated in murine fibrotic livers and promotes angiogenesis-related phenotypes (migration, tube formation, proliferation) in EOMA endothelial cells. Mechanistically, it is enriched in AGO2-RIP and acts as a miRNA sponge (including binding miR-200a-5p), increasing Stag1/STAG1 and engaging the STAG1_HIF1alpha signaling pathway to support pro-angiogenic programs in liver fibrosis."	0.765
36874972	PeerJ	2023	CircRNA expression profiles and functional analysis in a mouse model of chronic intermittent hypoxia-induced renal injury: new insight into pathogenesis.		mmu_circRNA_35869			renal injury	MONDO:0005300	chronic kidney disease	unknown	RT-qPCR; Microarray	mmu_circRNA_35869 was differentially expressed in CIH-induced renal injury and its expression change was validated by RT-qPCR. Bioinformatic prediction suggests it may act as a ceRNA by binding miR-107-3p in the context of OSA-induced renal damage.	0.4851
36874972	PeerJ	2023	CircRNA expression profiles and functional analysis in a mouse model of chronic intermittent hypoxia-induced renal injury: new insight into pathogenesis.		mmu_circRNA_27795			renal injury	MONDO:0005300	chronic kidney disease	unknown	RT-qPCR; Microarray	mmu_circRNA_27795 was identified as a differentially expressed circRNA in CIH-induced renal injury and its expression change was validated by RT-qPCR. No specific downstream miRNA/mRNA mechanism was assigned to this circRNA in the paper.	0.4468
36874972	PeerJ	2023	CircRNA expression profiles and functional analysis in a mouse model of chronic intermittent hypoxia-induced renal injury: new insight into pathogenesis.		mmu_circRNA_35632			renal injury	MONDO:0005300	chronic kidney disease	unknown	RT-qPCR; Microarray	mmu_circRNA_35632 was differentially expressed in CIH-induced renal injury and validated by RT-qPCR. Bioinformatic analysis predicted it may function as a ceRNA by binding miR-205-5p in OSA-induced renal damage.	0.4851
36874972	PeerJ	2023	CircRNA expression profiles and functional analysis in a mouse model of chronic intermittent hypoxia-induced renal injury: new insight into pathogenesis.		mmu_circRNA_009555			renal injury	MONDO:0005300	chronic kidney disease	unknown	RT-qPCR; Microarray	"mmu_circRNA_009555 was differentially expressed in CIH-induced renal injury and validated by RT-qPCR. It was included among five circRNAs used to construct a predicted circRNA_miRNA_mRNA ceRNA network, but no specific miRNA partner for this circRNA was stated in the text provided."	0.4851
36874972	PeerJ	2023	CircRNA expression profiles and functional analysis in a mouse model of chronic intermittent hypoxia-induced renal injury: new insight into pathogenesis.		mmu_circRNA_29626			renal injury	MONDO:0005300	chronic kidney disease	unknown	RT-qPCR; Microarray	mmu_circRNA_29626 was identified as a differentially expressed circRNA in CIH-induced renal injury and its expression change was validated by RT-qPCR. The study did not report a specific miRNA/mRNA regulatory axis for this circRNA.	0.4468
36874972	PeerJ	2023	CircRNA expression profiles and functional analysis in a mouse model of chronic intermittent hypoxia-induced renal injury: new insight into pathogenesis.		mmu_circRNA_37351			renal injury	MONDO:0005300	chronic kidney disease	unknown	RT-qPCR; Microarray	mmu_circRNA_37351 was differentially expressed in CIH-induced renal injury and validated by RT-qPCR. It was one of the five circRNAs used to construct a predicted circRNA_miRNA_mRNA ceRNA network related to OSA-induced renal injury.	0.4851
36875647	Frontiers in neuroscience	2023	Prenatal alcohol exposure results in brain region- and sex-specific changes in circHomer1 expression in adult mouse brain.		circHomer1	mmu_circ_Homer1	Homer1	Fetal Alcohol Spectrum Disorders / FASD	MONDO:0000408	fetal alcohol spectrum disorder	down-regulated	RT-qPCR	"In a mouse prenatal alcohol exposure model relevant to FASD, circHomer1 is significantly reduced in adult male frontal cortex and hippocampus. Mechanistically, H19 is proposed to inhibit EIF4A3-mediated circHomer1 biogenesis, and H19 knockdown increases circHomer1 expression in SH-SY5Y cells."	0.5812
36876724	The Kaohsiung journal of medical sciences	2023	Circular RNA circDLG1 (has_circ_0068706) functions as an oncogene in nonsmall cell lung cancer through regulating AKT/mTOR signaling and direct binding to miR-144.	hsa_circ_0068706	circDLG1	hsa_circ_DLG1	DLG1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"circDLG1 is up-regulated in NSCLC tissues and cell lines and functions as an oncogenic circRNA. It sponges miR-144 to elevate mTOR and activate AKT/mTOR signaling, thereby promoting proliferation, migration/invasion, tumor growth, and EMT-related metastatic traits; high circDLG1 is associated with poor patient survival."	0.8632
36878930	Scientific reports	2023	Identification of a novel circRNA-miRNA-mRNA regulatory axis in hepatocellular carcinoma based on bioinformatics analysis.	hsa_circ_0000417		hsa_circ_CPSF6	CPSF6	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	Microarray	hsa_circ_0000417 was identified by microarray-based differential expression and ceRNA-network bioinformatics as an upregulated circRNA in HCC. It is proposed to sponge hsa-miR-199a-5p to regulate WDR76 within a circRNA-miRNA-mRNA axis that shows diagnostic potential in HCC (ROC AUC > 0.7).	0.348
36878930	Scientific reports	2023	Identification of a novel circRNA-miRNA-mRNA regulatory axis in hepatocellular carcinoma based on bioinformatics analysis.	hsa_circ_0002688		hsa_circ_WHSC1	WHSC1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	Microarray	"hsa_circ_0002688 was identified via circRNA microarray and bioinformatics as an upregulated circRNA in HCC and incorporated into a ceRNA axis. It is predicted to bind hsa-miR-199a-5p and thereby relate to WDR76, showing diagnostic potential in HCC (ROC AUC 0.785)."	0.348
36878930	Scientific reports	2023	Identification of a novel circRNA-miRNA-mRNA regulatory axis in hepatocellular carcinoma based on bioinformatics analysis.	hsa_circ_0001387		hsa_circ_WHSC1	WHSC1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	Microarray	"hsa_circ_0001387 was identified by circRNA microarray and bioinformatics as an upregulated circRNA in HCC and included in a proposed ceRNA axis. It is predicted to bind hsa-miR-199a-5p and relate to WDR76, with diagnostic potential in HCC (ROC AUC 0.876)."	0.348
36882410	Signal transduction and targeted therapy	2023	CircRNA DICAR as a novel endogenous regulator for diabetic cardiomyopathy and diabetic pyroptosis of cardiomyocytes.	hsa_circ_0131202		hsa_circ_TULP4	TULP4	diabetic cardiomyopathy	MONDO:0004994	cardiomyopathy	down-regulated	RT-qPCR; Microarray	"DICAR (mm9_circ_008009; conserved human hsa_circ_0131202) is down-regulated in diabetic hearts and in AGEs-treated cardiomyocytes and protects against diabetic cardiomyopathy by inhibiting cardiomyocyte pyroptosis. Mechanistically, DICAR binds VCP via its junction domain, affecting VCP-mediated ubiquitin-proteasome degradation of Med12, thereby modulating pyroptosis; circulating DICAR in PBMCs/plasma is reduced in T2DM patients and may serve as a biomarker/therapeutic candidate."	0.8462
36882410	Signal transduction and targeted therapy	2023	CircRNA DICAR as a novel endogenous regulator for diabetic cardiomyopathy and diabetic pyroptosis of cardiomyocytes.		DICAR / mm9_circ_008009	mmu_circ_Tulp4	Tulp4	diabetic cardiomyopathy	MONDO:0004994	cardiomyopathy	down-regulated	RT-qPCR; Microarray	"DICAR (mm9_circ_008009; conserved human hsa_circ_0131202) is down-regulated in diabetic hearts and in AGEs-treated cardiomyocytes and protects against diabetic cardiomyopathy by inhibiting cardiomyocyte pyroptosis. Mechanistically, DICAR binds VCP via its junction domain, affecting VCP-mediated ubiquitin-proteasome degradation of Med12, thereby modulating pyroptosis; circulating DICAR in PBMCs/plasma is reduced in T2DM patients and may serve as a biomarker/therapeutic candidate."	0.8462
36888755	Acta cirurgica brasileira	2023	Circular RNA protein tyrosine kinase 2 aggravates pyroptosis and inflammation in septic lung tissue by promoting microRNA-766/eukaryotic initiation factor 5A axis-mediated ATP efflux.		circPTK2 / circular RNA PTK2	mmu_circ_PTK2	PTK2	sepsis-induced acute lung injury	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR	"circPTK2 is up-regulated in septic ALI models and promotes ATP efflux, pyroptosis, and inflammatory cytokine production. It functions as a ceRNA by sponging miR-766 to increase eIF5A expression, and circPTK2 knockdown alleviates lung injury phenotypes."	0.7052
36894874	BMC cancer	2023	The hsa_circ_0000276-ceRNA regulatory network and immune infiltration in cervical cancer.	hsa_circ_0000276	circ_0000276 / circTRIM22	hsa_circ_TRIM22	TRIM22	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000276 (circTRIM22) is up-regulated in HPV16-positive cervical cancer and directly binds miR-154-5p, functioning as a ceRNA. Its knockdown suppresses proliferation and G1/S progression and promotes apoptosis in SiHa and CaSki cells, with downstream effects involving genes such as CD47, LDHA, PDIA3 and SLC16A1 and links to immune infiltration."	0.6777
36894962	BMC medical genomics	2023	Expression alteration of serum exosomal circular RNAs in obstructive sleep apnea patients with acute myocardial infarction.		hsa_circRNA_101147 / circRNA_101147			obstructive sleep apnea with acute myocardial infarction / OSA with AMI	MONDO:0007147	obstructive sleep apnea syndrome	dysregulated	RT-qPCR; Microarray	Serum exosomal hsa_circRNA_101147 is differentially expressed in OSA patients with AMI and was validated by RT-qPCR in the same samples used for microarray profiling. The study does not report a specific downstream miRNA/target/mechanism for this circRNA.	0.4032
36894962	BMC medical genomics	2023	Expression alteration of serum exosomal circular RNAs in obstructive sleep apnea patients with acute myocardial infarction.		hsa_circRNA_101561 / circRNA_101561			obstructive sleep apnea with acute myocardial infarction / OSA with AMI	MONDO:0007147	obstructive sleep apnea syndrome	dysregulated	RT-qPCR; Microarray	Serum exosomal hsa_circRNA_101561 is differentially expressed in the study groups and its altered level was confirmed by RT-qPCR. No specific interacting miRNA/target or functional mechanism is experimentally established for this circRNA in the paper.	0.4032
36894962	BMC medical genomics	2023	Expression alteration of serum exosomal circular RNAs in obstructive sleep apnea patients with acute myocardial infarction.		hsa_circRNA_101328 / circRNA_101328			obstructive sleep apnea with acute myocardial infarction / OSA with AMI	MONDO:0007147	obstructive sleep apnea syndrome	dysregulated	RT-qPCR; Microarray	Serum exosomal hsa_circRNA_101328 is among six circRNAs whose differential expression was validated by RT-qPCR and is associated with OSA with AMI in this profiling study. The paper does not provide an experimentally validated mechanism for this circRNA.	0.4032
36894962	BMC medical genomics	2023	Expression alteration of serum exosomal circular RNAs in obstructive sleep apnea patients with acute myocardial infarction.		hsa_circRNA_104172 / circRNA_104172			obstructive sleep apnea with acute myocardial infarction / OSA with AMI	MONDO:0007147	obstructive sleep apnea syndrome	dysregulated	RT-qPCR; Microarray	Serum exosomal hsa_circRNA_104172 is one of six circRNAs with differential expression validated by RT-qPCR in OSA patients with AMI. The paper does not experimentally define its downstream targets or mechanism.	0.4032
36894962	BMC medical genomics	2023	Expression alteration of serum exosomal circular RNAs in obstructive sleep apnea patients with acute myocardial infarction.		hsa_circRNA_104640 / circRNA_104640			obstructive sleep apnea with acute myocardial infarction / OSA with AMI	MONDO:0007147	obstructive sleep apnea syndrome	dysregulated	RT-qPCR; Microarray	"Serum exosomal hsa_circRNA_104640 is differentially expressed in OSA patients with AMI and validated by RT-qPCR. Bioinformatics suggests it may function in a circRNA_miRNA_mRNA network as a sponge for many miRNAs and be linked to multiple mRNAs, but specific miRNAs/targets are not experimentally confirmed for this circRNA."	0.4032
36894962	BMC medical genomics	2023	Expression alteration of serum exosomal circular RNAs in obstructive sleep apnea patients with acute myocardial infarction.		hsa_circRNA_104642 / circRNA_104642			obstructive sleep apnea with acute myocardial infarction / OSA with AMI	MONDO:0007147	obstructive sleep apnea syndrome	dysregulated	RT-qPCR; Microarray	"Serum exosomal hsa_circRNA_104642 is differentially expressed in OSA patients with AMI, validated by RT-qPCR, and directly binds miR-29a-3p as shown by dual-luciferase reporter assays in 293T cells. The authors suggest it may aid differential diagnosis of AMI in OSA patients; a downstream Bax link is proposed but not established in this study."	0.5922
36895010	Journal of translational medicine	2023	CircDNAJC11 interacts with TAF15 to promote breast cancer progression via enhancing MAPK6 expression and activating the MAPK signaling pathway.	hsa_circ_0008389	circDNAJC11	hsa_circ_DNAJC11	DNAJC11	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; ISH; Microarray	"circDNAJC11 (hsa_circ_0008389), derived from DNAJC11, is up-regulated in breast cancer (including TNBC) and mainly localizes in the cytoplasm. It promotes proliferation, migration, invasion and tumor growth while inhibiting apoptosis, by binding the RBP TAF15 to stabilize MAPK6 mRNA and activate MAPK signaling. High circDNAJC11 expression is associated with worse overall survival and is an independent prognostic risk factor in BC."	0.8815
36897170	Aging	2023	A novel circular RNA circRBMS3 regulates proliferation and metastasis of osteosarcoma by targeting miR-424-eIF4B/YRDC axis.	hsa_circ_0064644	circRBMS3 / novel_circ_0064644	hsa_circ_RBMS3	RBMS3	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Northern Blot; ISH; RNA-seq	"circRBMS3 (hsa_circ_0064644), derived from RBMS3 exons 7_10, is up-regulated in osteosarcoma and mainly localized in the cytoplasm. It promotes OS cell proliferation, migration/invasion and in vivo tumorigenesis/bone destruction by acting as a ceRNA that sponges miR-424-5p to upregulate EIF4B and YRDC; ADAR1 downregulation contributes to circRBMS3 overexpression."	0.8535
36899354	Cancer cell international	2023	Hypoxia-responsive circular RNA circAAGAB reduces breast cancer malignancy by activating p38 MAPK and sponging miR-378 h.		circAAGAB / circ-AAGAB	hsa_circ_AAGAB	AAGAB	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; RNA-seq	"circAAGAB is a hypoxia-downregulated, cytoplasmic circRNA from AAGAB that suppresses breast cancer malignant phenotypes by binding FUS (stabilization) and acting as a ceRNA for miR-378 h to de-repress KIAA1522/NKX3-1/JADE3. It activates p38 MAPK signaling and reduces colony formation, migration/invasion and EMT, while increasing radiosensitivity (especially after ionizing radiation)."	0.7962
36899402	Acta neuropathologica communications	2023	The oncogenic circular RNA circ_63706 is a potential therapeutic target in sonic hedgehog-subtype childhood medulloblastomas.		circ_63706 / hsa-PCNT_0003	hsa_circ_PCNT	PCNT	medulloblastoma / MB	MONDO:0007959	medulloblastoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circ_63706 is an SHH-subgroup-enriched oncogenic circRNA in childhood medulloblastoma. Its depletion suppresses proliferation, migration/invasion, and intracranial xenograft tumor growth, and shifts lipid metabolism toward increased oxidized lipids/ceramides with reduced triglycerides. The study also predicts potential miRNA binders and reports that circ_63706 acts independently of its host gene PCNT."	0.6686
36900344	Cancers	2023	Circular RNA Expression Signatures Provide Promising Diagnostic and Therapeutic Biomarkers for Chronic Lymphocytic Leukemia.		circKAT6A	hsa_circ_KAT6A	KAT6A	chronic lymphocytic leukemia / CLL	MONDO:0003864	chronic lymphocytic leukemia/small lymphocytic lymphoma	up-regulated	RNA-seq	"circKAT6A is up-regulated in CLL lymphocytes and is part of a four-circRNA diagnostic/prognostic panel. Bioinformatic network analysis suggests it impacts PDGF/CCKR signaling and B-cell activation, and higher expression is associated with worse overall survival in larger validation cohorts."	0.5121
36900344	Cancers	2023	Circular RNA Expression Signatures Provide Promising Diagnostic and Therapeutic Biomarkers for Chronic Lymphocytic Leukemia.		circLNPEP	hsa_circ_LNPEP	LNPEP	chronic lymphocytic leukemia / CLL	MONDO:0003864	chronic lymphocytic leukemia/small lymphocytic lymphoma	up-regulated	RNA-seq	"circLNPEP is increased in CLL and serves as part of a diagnostic/prognostic circRNA panel. It is predicted to function via miRNA sponging (miR-15a-5p/miR-19a-3p/miR-135a-5p/miR-138-5p) to influence intracellular signal transduction-related activation programs, and higher expression is linked to worse OS in validation cohorts."	0.5121
36900344	Cancers	2023	Circular RNA Expression Signatures Provide Promising Diagnostic and Therapeutic Biomarkers for Chronic Lymphocytic Leukemia.		circMDM2	hsa_circ_MDM2	MDM2	chronic lymphocytic leukemia / CLL	MONDO:0003864	chronic lymphocytic leukemia/small lymphocytic lymphoma	up-regulated	RNA-seq	"circMDM2 is increased in CLL and included in a diagnostic/prognostic circRNA panel. Network analysis links circMDM2 to miRNA-mediated interactions (miR-137/miR-7 and miR-193 family) with targets such as NFIX, SNTB2 and RAF1, affecting cell cycle/apoptosis programs and contributing to CLL progression; higher expression correlates with worse OS in validation cohorts."	0.5121
36900344	Cancers	2023	Circular RNA Expression Signatures Provide Promising Diagnostic and Therapeutic Biomarkers for Chronic Lymphocytic Leukemia.		circMYH9	hsa_circ_MYH9	MYH9	chronic lymphocytic leukemia / CLL	MONDO:0003864	chronic lymphocytic leukemia/small lymphocytic lymphoma	up-regulated	RNA-seq	"circMYH9 is increased in CLL and is part of a four-circRNA diagnostic/prognostic signature. Network analysis links circMYH9 with NCK2/CBL/STAM2 and suggests impacts on angiogenesis, B-cell activation and EGFR signaling; higher expression is associated with worse OS in validation cohorts."	0.5121
36901741	International journal of molecular sciences	2023	circRNA from APP Gene Changes in Alzheimer's Disease Human Brain.	hsa_circ_0007556	circAPP	hsa_circ_APP	APP	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR	"circAPP (hsa_circ_0007556), derived from APP, is significantly down-regulated in the entorhinal cortex of Alzheimer¡¯s disease patients versus controls. The study confirms its back-splice junction by RT-PCR and Sanger sequencing and quantifies decreased expression by RT-qPCR; bioinformatics predicts 17 interacting miRNAs and enrichment in pathways such as Wnt signaling and long-term potentiation."	0.5466
36902312	International journal of molecular sciences	2023	Combinatorial Blood Platelets-Derived circRNA and mRNA Signature for Early-Stage Lung Cancer Detection.		hsa_circRNA_101367	hsa_circ_FUT8	FUT8	lung cancer	MONDO:0008903	lung cancer	up-regulated	Microarray	"In platelets from lung cancer patients, circFUT8 was identified as significantly up-regulated compared with controls. Prior evidence cited by the authors suggests circFUT8 may regulate lung cancer cell proliferation, invasion and apoptosis via miR-145 and the miR-944/YES1 axis."	0.1768
36902312	International journal of molecular sciences	2023	Combinatorial Blood Platelets-Derived circRNA and mRNA Signature for Early-Stage Lung Cancer Detection.		circSLC8A1	hsa_circ_SLC8A1	SLC8A1	lung cancer	MONDO:0008903	lung cancer	unknown	Microarray	"circSLC8A1 is part of the selected platelet circRNA features in the combined mRNA/circRNA machine-learning models that classify lung cancer vs controls, and is retained in the early-stage lung cancer detection signature."	0.1768
36902312	International journal of molecular sciences	2023	Combinatorial Blood Platelets-Derived circRNA and mRNA Signature for Early-Stage Lung Cancer Detection.		circCHD9	hsa_circ_CHD9	CHD9	lung cancer	MONDO:0008903	lung cancer	unknown	Microarray	"circCHD9 is part of the selected platelet circRNA features in the combined mRNA/circRNA machine-learning models that classify lung cancer vs controls, and is retained in the early-stage lung cancer detection signature."	0.1768
36908025	Epigenetics	2023	Circ_0078607 increases platinum drug sensitivity via miR-196b-5p/GAS7 axis in ovarian cancer.	hsa_circ_0078607		hsa_circ_SLC22A3	SLC22A3	ovarian cancer / OC	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR	"circ_0078607 is down-regulated in ovarian cancer tissues and cisplatin-resistant cells and functions as a cytoplasmic ceRNA. By sponging miR-196b-5p, it up-regulates GAS7, suppresses malignant phenotypes, and increases cisplatin (DDP) sensitivity in vitro and in xenograft models; low circ_0078607 is associated with worse overall survival."	0.8656
36908822	PeerJ	2023	METTL3-mediated m6A modification of has_circ_0007905 promotes age-related cataract progression through miR-6749-3p/EIF4EBP1.	hsa_circ_0007905	circSTX6	hsa_circ_STX6	STX6	age-related cataract / ARC	MONDO:0004847	senile cataract	up-regulated	RT-qPCR; RNA-seq	"In age-related cataract, has_circ_0007905 is hypermethylated (m6A) and upregulated in lens samples and UVB-induced HLE-B3 cells. It promotes apoptosis and suppresses proliferation by functioning as an AGO2-dependent ceRNA that sponges miR-6749-3p to regulate EIF4EBP1, and its m6A modification is mediated by METTL3."	0.841
36911697	Frontiers in immunology	2023	Identification of hsa_circRNA_100632 as a novel molecular biomarker for fulminant type 1 diabetes.		hsa_circRNA_100632	hsa_circ_SAMD8	SAMD8	type 1 diabetes mellitus / T1DM	MONDO:0005147	type 1 diabetes mellitus	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_100632 (derived from SAMD8) is up-regulated in PBMCs of FT1D (and also T1D) patients and shows diagnostic performance for distinguishing FT1D from controls and from T1D. Mechanistically, it is predicted to act via a circRNA_miRNA_mRNA ceRNA network (e.g., sponging miR-221-3p/miR-222-3p or miR-27a-3p to affect targets such as THBS1/SLC40A1/ALDH1A1 or NFAT5), potentially linking to immune regulation in FT1D."	0.5047
36911697	Frontiers in immunology	2023	Identification of hsa_circRNA_100632 as a novel molecular biomarker for fulminant type 1 diabetes.		hsa_circRNA_005528	hsa_circ_ANAPC1P1	ANAPC1P1	type 1 diabetes mellitus / T1DM	MONDO:0005147	type 1 diabetes mellitus	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_005528 is down-regulated in PBMCs of FT1D and T1D patients compared with controls, based on microarray discovery and qRT-PCR validation. The study does not report a specific mechanism, pathway, or clinical diagnostic utility for this circRNA."	0.3588
36915149	Respiratory research	2023	Circ-Ntrk2 acts as a miR-296-5p sponge to activate the TGF-beta1/p38 MAPK pathway and promote pulmonary hypertension and vascular remodelling.		circ-Ntrk2	mmu_circ_Ntrk2	Ntrk2	pulmonary arterial hypertension / PAH	MONDO:0015924	pulmonary arterial hypertension	up-regulated	RT-qPCR; RNA-seq	"In hypoxia-induced PAH (mouse lung tissue and PASMCs), circ-Ntrk2 is up-regulated and mainly localized in the cytoplasm. It promotes PASMC proliferation and pulmonary vascular remodeling by sponging miR-296-5p, thereby increasing TGF-beta1 and activating the p38 MAPK pathway."	0.7564
36922872	Journal of experimental & clinical cancer research : CR	2023	CircFOXK2 promotes hepatocellular carcinoma progression and leads to a poor clinical prognosis via regulating the Warburg effect.	hsa_circ_0000817	circFOXK2 / hsa_circ_0000817	hsa_circ_FOXK2	FOXK2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"CircFOXK2 (hsa_circ_0000817) is upregulated in HCC and promotes proliferation, invasion and in vivo tumor growth/metastasis. It enhances the Warburg effect by encoding FOXK2-142aa to increase LDHA Tyr10 phosphorylation and by sponging miR-484 to upregulate Fis1-driven mitochondrial fission, and high expression predicts poor OS after hepatectomy."	0.8904
36922993	iScience	2023	CircSTK3 drives the metastasis of colorectal cancer by regulating epithelial-mesenchymal transition.	hsa_circ_0004592	circSTK3	hsa_circ_STK3	STK3	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; Microarray	"circSTK3 (hsa_circ_0004592), derived from STK3, is up-regulated in colorectal cancer tissues and is mainly localized in the cytoplasm. Functional assays show it promotes CRC cell migration, invasion, and in vivo lung metastasis by inducing EMT programs, and its high expression predicts poor overall survival; CTCF transcriptionally promotes circSTK3 expression."	0.7956
36923408	Frontiers in immunology	2023	CircRNA_0075723 protects against pneumonia-induced sepsis through inhibiting macrophage pyroptosis by sponging miR-155-5p and regulating SHIP1 expression.	hsa_circ_0075723	CircRNA_0075723 / circ_0075723	hsa_circ_NUP153	NUP153	pneumonia-induced sepsis	MONDO:0005229	bacterial infectious disease with sepsis	down-regulated	RT-qPCR; RNA-seq	"circ_0075723 is down-regulated in plasma/CD14+ monocytes from pneumonia-induced sepsis patients. It suppresses macrophage pyroptosis and inflammatory cytokine release by sponging miR-155-5p to increase SHIP1 expression, which in turn dampens TLR4/NLRP3 inflammasome activation and helps preserve endothelial integrity via VE-cadherin."	0.8335
36926584	Frontiers in genetics	2023	Age-related ceRNA networks in adult Drosophila ageing.	dme_circ_0009500		dme_circ_pan	pan	ageing / aging			down-regulated	RT-qPCR; RNA-seq	"dme_circ_0009500 is down-regulated in 42-day-old vs 7-day-old Drosophila and is part of age-related ceRNA networks. It likely functions by competitively binding dme_miR-289-5p or dme_miR-985-3p to modulate targets including CG31064, frizzled, and Abl."	0.2465
36926584	Frontiers in genetics	2023	Age-related ceRNA networks in adult Drosophila ageing.	dme_circ_0008173		dme_circ_Nlg1	Nlg1	ageing / aging			unknown	RT-qPCR; RNA-seq	dme_circ_0008173 is an age-associated DE circRNA whose expression was validated by qPCR to match RNA-seq results and was further profiled for tissue-specific expression (head/ovary/gut/fat body). The paper does not specify its miRNA/mRNA regulatory axis.	0.3588
36926584	Frontiers in genetics	2023	Age-related ceRNA networks in adult Drosophila ageing.	dme_circ_0009667		dme_circ_dlg1	dlg1	ageing / aging			up-regulated	RT-qPCR; RNA-seq	dme_circ_0009667 is up-regulated in older (42-day) flies and was validated by qPCR to match RNA-seq results. It shows ovary-enriched expression in tissue profiling; no specific miRNA/mRNA axis was reported for this circRNA.	0.1904
36926584	Frontiers in genetics	2023	Age-related ceRNA networks in adult Drosophila ageing.	dme_circ_0010536		dme_circ_slgA	slgA	ageing / aging			up-regulated	RT-qPCR; RNA-seq	"dme_circ_0010536 is up-regulated in older flies and its differential expression was supported by RNA-seq and validated by qPCR. The study further profiled its tissue-specific expression, but did not report a specific miRNA/mRNA ceRNA axis for this circRNA."	0.1904
36932387	Molecular cancer	2023	Exosome-derived circCCAR1 promotes CD8_+_T-cell dysfunction and anti-PD1 resistance in hepatocellular carcinoma.	hsa_circ_0000240	circCCAR1 / circ_0000240	hsa_circ_CCAR1	CCAR1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circCCAR1 is up-regulated in HCC tumor tissue and enriched in circulating exosomes. It promotes HCC proliferation and metastasis via a circCCAR1/miR-127-5p/WTAP ceRNA feedback loop and is stabilized by WTAP-mediated m6A with IGF2BP3. Exosomal circCCAR1 enters CD8+ T cells and directly binds PD1 to reduce ubiquitination and proteasomal degradation, driving T-cell dysfunction and anti-PD1 resistance, and higher levels indicate poor prognosis."	0.8988
36932454	Journal of experimental & clinical cancer research : CR	2023	circMMD reduction following tumor treating fields inhibits glioblastoma progression through FUBP1/FIR/DVL1 and miR-15b-5p/FZD6 signaling.	hsa_circ_0044705	circMMD	hsa_circ_MMD	MMD	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circMMD is up-regulated in glioma/GBM and associates with poor prognosis. Functionally it promotes GBM proliferation and Wnt/beta-catenin activation. Mechanistically, TTF reduces circMMD biogenesis via EIF4A3, while circMMD activates Wnt/beta-catenin through modulating the FUBP1/FIR/DVL1 transcriptional module and sponging miR-15b-5p to upregulate FZD6."	0.8987
36934637	Translational oncology	2023	Plasma exosome-derived circGAPVD1 as a potential diagnostic marker for colorectal cancer.	hsa_circ_0003270	circGAPVD1	hsa_circ_GAPVD1	GAPVD1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circGAPVD1 (hsa_circ_0003270) is up-regulated in plasma exosomes from colorectal cancer patients and shows diagnostic performance by ROC analysis. Higher circGAPVD1 levels correlate with lymph node metastasis and advanced TNM stage, and bioinformatic ceRNA modeling links circGAPVD1 with miRNAs (e.g., hsa-miR-532_3p, hsa-miR-5047) and downstream mRNAs (GLU, FOSL2, GALNT6, NOP2)."	0.6616
36934637	Translational oncology	2023	Plasma exosome-derived circGAPVD1 as a potential diagnostic marker for colorectal cancer.	hsa_circ_0043278	circTADA2A	hsa_circ_TADA2A	TADA2A	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	circTADA2A (hsa_circ_0043278) is elevated in CRC plasma exosomes versus healthy controls and shows modest diagnostic ability (reported AUC 0.6482) in the initial 35-pair validation set.	0.4187
36934637	Translational oncology	2023	Plasma exosome-derived circGAPVD1 as a potential diagnostic marker for colorectal cancer.	hsa_circ_0004071	circMYO9B	hsa_circ_MYO9B	MYO9B	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	circMYO9B (hsa_circ_0004071) is increased in CRC plasma exosomes and shows diagnostic ability (AUC 0.6914) in the initial 35-pair validation set.	0.4187
36934637	Translational oncology	2023	Plasma exosome-derived circGAPVD1 as a potential diagnostic marker for colorectal cancer.	hsa_circ_0092310	circTJAP1	hsa_circ_TJAP1	TJAP1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circTJAP1 (hsa_circ_0092310) is elevated in CRC plasma exosomes in the initial validation set; its ROC performance was low and not statistically significant (AUC 0.6143, P = 0.1103)."	0.4187
36937538	Journal of diabetes research	2023	Identification of Potentially Functional Circular RNA/Long Noncoding RNA-MicroRNA-mRNA Regulatory Networks Associated with Vascular Injury in Type 2 Diabetes Mellitus by Integrated Microarray Analysis.	hsa_circ_0020316	circ_0020316			Type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RT-qPCR	circ_0020316 is upregulated in peripheral blood of T2DM patients with macroangiopathy. It binds miR-92a-2-5p and is proposed to promote T2DM-related vascular injury by relieving miR-92a-2-5p repression of MAPK3 (ceRNA network).	0.4685
36941600	Journal of orthopaedic surgery and research	2023	"Circ_0000479 promotes proliferation, invasion, migration and inflammation and inhibits apoptosis of rheumatoid arthritis fibroblast-like synoviocytes via miR-766/FKBP5 axis."	hsa_circ_0000479	circ_0000479	hsa_circ_EPSTI1	EPSTI1	rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"circ_0000479 is up-regulated in RA-FLS (MH7A) cells and mainly localized in the cytoplasm. It promotes RA-FLS proliferation, invasion, migration and inflammatory cytokine production while inhibiting apoptosis by sponging miR-766 and thereby increasing FKBP5 expression."	0.7221
36941992	"Open medicine (Warsaw, Poland)"	2023	CircRANBP17 modulated KDM1A to regulate neuroblastoma progression by sponging miR-27b-3p.		circRANBP17	hsa_circ_RANBP17	RAN binding protein 17	neuroblastoma / NB	MONDO:0005072	neuroblastoma	up-regulated	RT-qPCR	"circRANBP17 is up-regulated in neuroblastoma tissues/cells and mainly localized in the cytoplasm. It promotes NB malignant behaviors (proliferation, migration, invasion, tumor growth) and inhibits apoptosis by sponging miR-27b-3p to increase KDM1A expression."	0.8201
36949500	Journal of orthopaedic surgery and research	2023	Circ_0002715 promotes the development of osteoarthritis through regulating LXN by sponging miR-127-5p.	hsa_circ_0002715	circular RNA_0002715 / circ_0002715			osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"Circ_0002715 is up-regulated in osteoarthritic cartilage and IL-1beta-induced CHON-001 cells, mainly localizing to the cytoplasm. It promotes chondrocyte injury (inflammation, apoptosis, and ECM degradation) by acting as a ceRNA that sponges miR-127-5p and thereby increases LXN expression."	0.7785
36949536	Hereditas	2023	Circular RNA circHMCU promotes breast tumorigenesis through miR-4458/PGK1 regulatory cascade.	hsa_circ_0000247	circHMCU	hsa_circ_HMCU	HMCU	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circHMCU (hsa_circ_0000247) is up-regulated in breast cancer tissues and cell lines and acts as an oncogenic circRNA. It sponges miR-4458 to increase PGK1, thereby promoting glycolysis and malignant phenotypes (proliferation, migration/invasion) and suppressing apoptosis, and its knockdown reduces xenograft tumor growth."	0.8299
36951484	Acta biochimica et biophysica Sinica	2023	Roles of the hsa_circ_0013880/USP32/Rap1b axis in the proliferation and apoptosis of acute myeloid leukemia cells.	hsa_circ_0013880		hsa_circ_TXNIP	TXNIP	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"hsa_circ_0013880 is up-regulated in BMNCs from AML patients and promotes AML cell proliferation and migration while inhibiting apoptosis. Mechanistically, it increases USP32 expression, and the USP32 deubiquitination activity stabilizes Rap1b; hsa_circ_0013880 can bind miR-148a-3p and miR-20a-5p and is proposed to regulate USP32 through a ceRNA-like network."	0.7591
36951687	Clinical cancer research : an official journal of the American Association for Cancer Research	2023	A Tumor-suppressive Molecular Axis EP300/circRERE/miR-6837-3p/MAVS Activates Type I IFN Pathway and Antitumor Immunity to Suppress Colorectal Cancer.		hsa_circ_12952	hsa_circ_RERE	RERE	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"In colorectal cancer, circRERE is down-regulated and functions as a tumor suppressor. It sponges miR-6837-3p to increase MAVS, activating MAVS-driven type I IFN signaling and enhancing antitumor immunity; EP300 promotes circRERE transcription via the RERE promoter. AAV-mediated circRERE delivery suppresses tumor growth and sensitizes anti-PD-1 therapy in mouse models."	0.8644
36951687	Clinical cancer research : an official journal of the American Association for Cancer Research	2023	A Tumor-suppressive Molecular Axis EP300/circRERE/miR-6837-3p/MAVS Activates Type I IFN Pathway and Antitumor Immunity to Suppress Colorectal Cancer.			mmu_circ_Rere	RERE	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"In colorectal cancer, circRERE is down-regulated and functions as a tumor suppressor. It sponges miR-6837-3p to increase MAVS, activating MAVS-driven type I IFN signaling and enhancing antitumor immunity; EP300 promotes circRERE transcription via the RERE promoter. AAV-mediated circRERE delivery suppresses tumor growth and sensitizes anti-PD-1 therapy in mouse models."	0.8644
36958293	Urologia internationalis	2023	Hsa_circ_0008035 Knockdown Inhibits Bladder Cancer Progression through miR-1184/RAP2B Axis.	hsa_circ_0008035	circ_0008035 / circ-0008035	hsa_circ_EXT1	EXT1	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0008035 (circ_0008035), derived from EXT1, is upregulated in bladder cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes malignant phenotypes (proliferation, migration/invasion, angiogenesis, EMT) and inhibits apoptosis by sponging miR-1184 to upregulate RAP2B, and its silencing suppresses xenograft tumor growth."	0.8256
36961927	Proceedings of the National Academy of Sciences of the United States of America	2023	circNEIL3 inhibits tumor metastasis through recruiting the E3 ubiquitin ligase Nedd4L to degrade YBX1.	hsa_circ_0001460	circNEIL3	hsa_circ_NEIL3	NEIL3	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"circNEIL3 (hsa_circ_0001460), derived from the NEIL3 gene, is down-regulated in CRC liver metastatic lesions versus paired primary tumors and is repressed by TGFbeta. It inhibits migration/invasion and metastasis by directly binding the RBP YBX1 and recruiting the E3 ligase Nedd4L to promote YBX1 polyubiquitination and proteasomal degradation. Clinically, lower circNEIL3 levels are associated with lymph node metastasis and poorer overall survival in CRC."	0.8816
36965082	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2023	Exosome-Based Mitochondrial Delivery of circRNA mSCAR Alleviates Sepsis by Orchestrating Macrophage Activation.		circRNA mSCAR / circRNA SCAR	mmu_circ_ATP5B	ATP5B	sepsis	MONDO:0005229	bacterial infectious disease with sepsis	down-regulated	RT-qPCR; ISH	"circRNA mSCAR is reduced in macrophages/monocytes in septic mice. Mitochondria-targeted exosomal delivery of circRNA mSCAR lowers mtROS, improves mitochondrial function, suppresses M1 polarization while promoting M2 polarization, reduces systemic inflammation, and improves survival in the CLP sepsis model."	0.7618
36966311	Cancer cell international	2023	A novel feedback regulated loop of circRRM2-IGF2BP1-MYC promotes breast cancer metastasis.	hsa_circ_0052582	circRRM2	hsa_circ_RRM2	RRM2	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circRRM2 (hsa_circ_0052582) is up-regulated in breast cancer tissues/cell lines and promotes migration and invasion. It functions as a ceRNA sponging miR-27b-3p and miR-31-5p to increase IGF2BP1, and IGF2BP1 interacts with MYC to enhance circRRM2 transcription, forming a positive feedback loop that supports metastasis."	0.8208
36966311	Cancer cell international	2023	A novel feedback regulated loop of circRRM2-IGF2BP1-MYC promotes breast cancer metastasis.	hsa_circ_0058113				breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0058113 was identified as up-regulated in breast cancer tissues and cell lines and validated as a circular RNA, with nucleus-and-cytoplasm localization. Its knockdown did not affect breast cancer cell migration in this study, and no specific mechanism was established."	0.5739
36966311	Cancer cell international	2023	A novel feedback regulated loop of circRRM2-IGF2BP1-MYC promotes breast cancer metastasis.	hsa_circ_0058148				breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0058148 was identified as up-regulated in breast cancer tissues and cell lines and validated as a circular RNA, predominantly localized in the nucleus. Its knockdown did not affect breast cancer cell migration in this study, and no specific mechanism was established."	0.5739
36966311	Cancer cell international	2023	A novel feedback regulated loop of circRRM2-IGF2BP1-MYC promotes breast cancer metastasis.	hsa_circ_0060551				breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0060551 was identified as up-regulated in breast cancer tissues and cell lines and validated as a circular RNA, predominantly localized in the nucleus. Its knockdown did not affect breast cancer cell migration in this study, and no specific mechanism was established."	0.5739
36966421	Molecular and cellular biochemistry	2023	Biochemical study of the effect of mesenchymal stem cells-derived exosome versus L-Dopa in experimentally induced Parkinson's disease in rats.		circRNA.2837 / circRNA 2837			Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	up-regulated	RT-qPCR	"In the rotenone-induced rat PD model, circRNA 2837 is up-regulated in brain tissue and negatively correlated with miRNA-34b. BM-MSC-derived exosome treatment represses circRNA 2837, consistent with a sponge-like circRNA 2837/miRNA-34b mechanism that is linked to reduced alpha-synuclein and increased PARKIN and DJ-1."	0.5546
36969321	Biochemistry and biophysics reports	2023	Hypoxia-treated umbilical mesenchymal stem cell alleviates spinal cord ischemia-reperfusion injury in SCI by circular RNA circOXNAD1/ miR-29a-3p/ FOXO3a axis.		circOXNAD1 / circRNA OXNAD1	hsa_circ_OXNAD1	OXNAD1	spinal cord ischemia reperfusion injury	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR	"Hypoxia increases circOXNAD1 in HucMSC-derived exosomes, and these exosomes protect against spinal cord ischemia-reperfusion injury. circOXNAD1 acts as a ceRNA by sponging miR-29a-3p, thereby increasing FOXO3a and reducing neuronal apoptosis and inflammation while improving cell viability and motor outcomes."	0.5998
36974922	Journal of cellular and molecular medicine	2023	The Circ_35953 induced by the NF-kappaB mediated the septic AKI via targeting miR-7219-5p/HOOK3 and IGFBP7 axis.		CircRNA_35953 / Circ_35953 	mmu_circ_Cttnbp2nl	cttnbp2nl	sepsis-induced acute kidney injury	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR	"Circ_35953 is up-regulated in LPS-treated tubular cells and in CLP-induced septic AKI, promotes tubular cell apoptosis, and aggravates AKI. Mechanistically, it is induced by NF-kappaB and functions as a ceRNA that sponges miR-7219-5p to increase HOOK3 and IGFBP7 expression."	0.6585
36980172	Cells	2023	CircXPO1 Promotes Glioblastoma Malignancy by Sponging miR-7-5p.		circXPO1 / hsa_circ_102737	hsa_circ_XPO1	XPO1	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; Microarray	"circXPO1 is up-regulated in glioma/GBM tissues and cell lines and promotes proliferation, cell-cycle progression, migration, and in vivo tumor growth. Mechanistically, it acts as a ceRNA that sponges miR-7-5p, leading to increased RAF1 expression and enhanced GBM malignancy."	0.8458
36980823	Genes	2023	Competing Endogenous RNA Regulatory Networks of hsa_circ_0126672 in Pathophysiology of Coronary Heart Disease.	hsa_circ_0126672	hsa_circ _0126672			Coronary heart disease / CHD	MONDO:0005010	coronary artery disorder	up-regulated	Microarray	"This study computationally proposes that hsa_circ_0126672 is up-regulated in CHD peripheral blood and contributes to CHD via a ceRNA mechanism by sponging multiple miRNAs (notably miR-145-5p). The predicted downstream effects include increased expression of target genes and activation of CHD-relevant pathways such as JAK/STAT and Apelin, promoting processes like atherosclerosis."	0.1768
36980895	Genes	2023	Integration Analysis of circRNA-miRNA-mRNA and Identification of Critical Networks in Valgus-Varus Deformity (Gallus gallus).		novel_circ_0002771			Valgus-valgus deformity / VVD	MONDO:0002081	musculoskeletal system disorder	unknown	RNA-seq	"This study identified novel_circ_0002771 as part of a predicted ceRNA axis in VVD broiler cartilage, potentially regulating CDC20 via sponging gga-let-7g-3p. The axis was prioritized as a key regulatory process from the constructed circRNA_miRNA_mRNA network, but the exact mechanism was not experimentally confirmed."	0.1768
36980895	Genes	2023	Integration Analysis of circRNA-miRNA-mRNA and Identification of Critical Networks in Valgus-Varus Deformity (Gallus gallus).		novel_circ_0000396			Valgus-valgus deformity / VVD	MONDO:0002081	musculoskeletal system disorder	unknown	RNA-seq	"This study identified novel_circ_0000396 as part of a predicted ceRNA axis in VVD broiler cartilage, potentially regulating CTNNB1 via sponging gga-miR-193a-3p. The axis was highlighted as a key regulatory process from network analysis, but the exact mechanism was not experimentally confirmed."	0.1768
36980895	Genes	2023	Integration Analysis of circRNA-miRNA-mRNA and Identification of Critical Networks in Valgus-Varus Deformity (Gallus gallus).		novel_circ_0001295			Valgus-valgus deformity / VVD	MONDO:0002081	musculoskeletal system disorder	dysregulated	RT-qPCR; RNA-seq	novel_circ_0001295 was identified as a differentially expressed circRNA in VVD versus normal broiler cartilage and was experimentally validated for circularity and expression consistency with sequencing data. No specific downstream miRNA/mRNA targets or functional mechanism were reported for this circRNA.	0.6571
36980895	Genes	2023	Integration Analysis of circRNA-miRNA-mRNA and Identification of Critical Networks in Valgus-Varus Deformity (Gallus gallus).		novel_circ_0001037			Valgus-valgus deformity / VVD	MONDO:0002081	musculoskeletal system disorder	dysregulated	RT-qPCR; RNA-seq	novel_circ_0001037 was identified as a differentially expressed circRNA in VVD versus normal broiler cartilage and was experimentally validated for circularity and expression consistency with sequencing data. No specific downstream miRNA/mRNA targets or functional mechanism were reported for this circRNA.	0.6571
36980895	Genes	2023	Integration Analysis of circRNA-miRNA-mRNA and Identification of Critical Networks in Valgus-Varus Deformity (Gallus gallus).		novel_circ_0000465			Valgus-valgus deformity / VVD	MONDO:0002081	musculoskeletal system disorder	dysregulated	RT-qPCR; RNA-seq	novel_circ_0000465 was identified as a differentially expressed circRNA in VVD versus normal broiler cartilage and was experimentally validated for circularity and expression consistency with sequencing data. No specific downstream miRNA/mRNA targets or functional mechanism were reported for this circRNA.	0.6571
36980895	Genes	2023	Integration Analysis of circRNA-miRNA-mRNA and Identification of Critical Networks in Valgus-Varus Deformity (Gallus gallus).		novel_circ_0004128			Valgus-valgus deformity / VVD	MONDO:0002081	musculoskeletal system disorder	dysregulated	RT-qPCR; RNA-seq	novel_circ_0004128 was identified as a differentially expressed circRNA in VVD versus normal broiler cartilage and was experimentally validated for circularity and expression consistency with sequencing data. No specific downstream miRNA/mRNA targets or functional mechanism were reported for this circRNA.	0.6571
36980895	Genes	2023	Integration Analysis of circRNA-miRNA-mRNA and Identification of Critical Networks in Valgus-Varus Deformity (Gallus gallus).		novel_circ_0005122			Valgus-valgus deformity / VVD	MONDO:0002081	musculoskeletal system disorder	dysregulated	RT-qPCR; RNA-seq	novel_circ_0005122 was identified as a differentially expressed circRNA in VVD versus normal broiler cartilage and was experimentally validated for circularity and expression consistency with sequencing data. No specific downstream miRNA/mRNA targets or functional mechanism were reported for this circRNA.	0.6571
36980895	Genes	2023	Integration Analysis of circRNA-miRNA-mRNA and Identification of Critical Networks in Valgus-Varus Deformity (Gallus gallus).		novel_circ_0003743			Valgus-valgus deformity / VVD	MONDO:0002081	musculoskeletal system disorder	dysregulated	RT-qPCR; RNA-seq	novel_circ_0003743 was identified as a differentially expressed circRNA in VVD versus normal broiler cartilage and was experimentally validated for circularity and expression consistency with sequencing data. No specific downstream miRNA/mRNA targets or functional mechanism were reported for this circRNA.	0.6571
36980960	Genes	2023	Identification of Circular RNA Profiles in the Liver of Diet-Induced Obese Mice and Construction of the ceRNA Network.		circRNA1709			obesity	MONDO:0011122	obesity disorder	dysregulated	RNA-seq	circRNA1709 is a differentially expressed circRNA in liver of diet-induced obese mice and is predicted to act in a ceRNA network. It may sponge miRNAs and influence lipid metabolism_related pathways (MAPK and PI3K/AKT) and potentially regulate PTEN-related insulin resistance mechanisms.	0.1768
36980960	Genes	2023	Identification of Circular RNA Profiles in the Liver of Diet-Induced Obese Mice and Construction of the ceRNA Network.		circRNA4842	mmu_circ_PTEN	PTEN	obesity	MONDO:0011122	obesity disorder	dysregulated	RNA-seq	"circRNA4842 is a differentially expressed PTEN-derived circRNA in liver of diet-induced obese mice. It is proposed as a candidate regulator related to PTEN and may be involved in lipid metabolism and insulin resistance, with validation focused on circRNA structure (divergent primers and Sanger sequencing)."	0.385
36982956	International journal of molecular sciences	2023	Circular RNA CircCDKN2B-AS_006 Promotes the Tumor-like Growth and Metastasis of Rheumatoid Arthritis Synovial Fibroblasts by Targeting the miR-1258/RUNX1 Axis.		hsa_circCDKN2B_AS_006			Rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; RNA-seq	"circCDKN2B_AS_006 is upregulated in RA synovium and RA synovial fibroblasts, where it promotes tumor-like proliferation, migration, and invasion. It functions as a ceRNA by sponging miR_1258 to increase RUNX1, thereby activating Wnt/beta-catenin signaling and promoting EMT; local knockdown in CIA mice alleviates arthritis severity and joint damage."	0.8931
36987415	Journal of medical biochemistry	2023	Diagnostic significance of hsa_circ_0000146 and hsa_circ_0000072 biomarkers for Diabetic Kidney Disease in patients with type 2 diabetes mellitus.	hsa_circ_0000146	circ_0000146 / circ_ 0000146			Diabetic Kidney Disease / DKD	MONDO:0005016	diabetic kidney disease	down-regulated	RT-qPCR	"hsa_circ_0000146 is down-regulated in DKD patient blood samples and shows diagnostic potential for distinguishing DKD from T2DM and for renal staging by ROC analysis. Mechanistically, the study used bioinformatics to predict that it may sponge miRNAs (including miR-21) and be linked to MAPK/RAS/TGF-beta-related pathways via KEGG-enriched target genes."	0.459
36987415	Journal of medical biochemistry	2023	Diagnostic significance of hsa_circ_0000146 and hsa_circ_0000072 biomarkers for Diabetic Kidney Disease in patients with type 2 diabetes mellitus.	hsa_circ_0000072	circ_0000072			Diabetic Kidney Disease / DKD	MONDO:0005016	diabetic kidney disease	down-regulated	RT-qPCR	"hsa_circ_0000072 is down-regulated in DKD patient blood samples and has moderate diagnostic performance for distinguishing DKD from T2DM, which improves when combined with CRP or CNR1. The study used bioinformatics to predict it may sponge miRNAs (notably miR-495) and be linked to TGF-beta, AMPK, and Wnt signaling pathways through KEGG-enriched target genes."	0.459
36989117	Epigenetics	2023	Suppressing circIDE/miR-19b-3p/RBMS1 axis exhibits promoting-tumour activity through upregulating GPX4 to diminish ferroptosis in hepatocellular carcinoma.	hsa_circ_0000251	circIDE	hsa_circ_IDE	IDE	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"circIDE (hsa_circ_0000251), derived from the IDE gene, is down-regulated in HCC and mainly localized in the cytoplasm. It sponges miR-19b-3p to increase RBMS1, thereby reducing GPX4 and promoting ferroptosis, which suppresses HCC cell proliferation and tumour growth; higher circIDE is associated with better survival."	0.8633
36991449	Biology direct	2023	circACTR2 attenuates gemcitabine chemoresiatance in pancreatic cancer through PTEN mediated PI3K/AKT signaling pathway.		circRNA_102747 / circACTR2	hsa_circ_ACTR2	ACTR2	pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	down-regulated	RT-qPCR; ISH; Microarray	"circACTR2 is down-regulated in gemcitabine-resistant pancreatic cancer and its low expression is linked to worse overall survival. Functionally, circACTR2 sensitizes PC cells to gemcitabine by promoting apoptosis and altering cell-cycle distribution. Mechanistically, it sponges miR-221-3p to upregulate PTEN and suppress PI3K/AKT signaling, thereby attenuating chemoresistance."	0.8844
36996491	Aging	2023	RNA helicase DDX5-induced circPHF14 promotes gastric cancer cell progression.	hsa_circ_0079440	circPHF14	hsa_circ_PHF14	PHF14	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"This study identifies circPHF14 (hsa_circ_0079440), derived from PHF14, as a DDX5-induced circRNA that promotes gastric cancer cell proliferation, migration, and xenograft tumor growth. Silencing circPHF14 partially reverses the tumor-promoting effects caused by DDX5 overexpression, indicating circPHF14 acts as a key downstream effector of DDX5 in gastric cancer."	0.6458
36998978	Frontiers in cardiovascular medicine	2023	Identification of hsa_circ_0001445 of a novel circRNA-miRNA-mRNA regulatory network as potential biomarker for coronary heart disease.	hsa_circ_0001445	hsa_circSMARCA5_013	hsa_circ_SMARCA5	SMARCA5	coronary heart disease / CHD	MONDO:0005010	coronary artery disorder	down-regulated	RT-qPCR	hsa_circ_0001445 is down-regulated in peripheral blood leukocytes of CHD patients and shows diagnostic utility (AUC 0.816). Bioinformatics analyses suggest it participates in a circRNA-miRNA-mRNA network potentially linked to PI3K-Akt signaling in CHD pathogenesis.	0.459
36999615	Oncology reports	2023	CircRPPH1 accelerates the proliferation and migration of bladder cancer via enhancing the STAT3 signaling pathway.	hsa_circ_0000512	circRPPH1	hsa_circ_RPPH1	RPPH1	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"circRPPH1 is up-regulated in bladder cancer cells and promotes proliferation, migration/invasion and in vivo tumor growth/metastasis. It functions as a ceRNA by sponging miR-296-5p to increase STAT3, and also binds the RBP FUS to facilitate nuclear transport of p-STAT3, thereby enhancing STAT3 signaling."	0.8626
37004067	Molecular cancer	2023	TGF-beta signaling promotes cervical cancer metastasis via CDR1as.		CDR1as			cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; ISH; RNA-seq; Microarray	"In cervical cancer, CDR1as is up-regulated after TGF-beta activation and promotes migration/invasion, EMT, and metastasis. Mechanistically, CDR1as binds IGF2BP1 and enhances IGF2BP1-mediated stabilization of Slug mRNA (m6A-related), and it activates TGF-beta/SMAD signaling (p-SMAD2/p-SMAD3), correlating clinically with lymph node metastasis and poorer survival."	0.8776
37005877	Cancer biomarkers : section A of Disease markers	2023	Hsa_circRNA_001859 regulates pancreatic cancer progression and epithelial-mesenchymal transition through the miR-21-5p/SLC38A2 pathway.		hsa_circRNA_001859 / circ_001859 / hsa_circ_001859	hsa_circ_ISY1	ISY1	pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_001859 (circ_001859) is down-regulated in pancreatic cancer tissues/cells and acts as a tumor suppressor. Its overexpression inhibits proliferation, migration/invasion and EMT by sponging miR-21-5p to up-regulate SLC38A2, and suppresses tumor growth in a nude-mouse xenograft model."	0.8351
37007569	Annals of translational medicine	2023	Circ_0003028 enhances the proliferation and glycolytic capacity and suppresses apoptosis in non-small cell lung cancer cells via the miR-1305/miR-1322-SLC5A1 axis.	hsa_circ_0003028	circ_0003028	hsa_circ_FUT8	FUT8	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"Circ_0003028 is up-regulated in NSCLC tissues and promotes malignant phenotypes by enhancing proliferation and glycolytic capacity while inhibiting apoptosis in NSCLC cells. Mechanistically, it is mainly cytoplasmic and is proposed to sponge miR-1305 and miR-1322 to increase SLC5A1 expression, contributing to increased glycolysis. Clinically, higher circ_0003028 expression is associated with poorer overall survival and shows diagnostic potential."	0.8135
37008055	Aging and disease	2023	Positive Feedback Regulation of Circular RNA Hsa_circ_0000566 and HIF-1alpha promotes Osteosarcoma Progression and Glycolysis Metabolism.	hsa_circ_0000566		hsa_circ_VRK1	VRK1	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; ISH; Microarray	"Hsa_circ_0000566 is upregulated in osteosarcoma, especially under hypoxia, and promotes malignant phenotypes and glycolysis. Mechanistically, HIF-1alpha transcriptionally induces Hsa_circ_0000566, while Hsa_circ_0000566 binds HIF-1alpha and VHL to block VHL-mediated ubiquitination, stabilizing HIF-1alpha and forming a positive feedback loop that enhances the Warburg effect."	0.8748
37008951	Frontiers in endocrinology	2023	Bioinformatic analysis confirms differences in circular RNA expression profiles of cumulus cells between patients with ovarian and peritoneal endometriosis-associated infertility.	hsa_circ_0004872		hsa_circ_MAPK1	MAPK1	peritoneal endometriosis-associated infertility	MONDO:0005133	endometriosis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0004872 is significantly upregulated in cumulus cells from patients with peritoneal endometriosis-associated infertility versus OEM and TFI controls. The study constructed a predicted ceRNA network for this circRNA (binding five miRNAs and many downstream mRNAs), suggesting it may contribute to impaired oocyte quality/competence and could serve as a noninvasive biomarker for concealed PEM."	0.4032
37008951	Frontiers in endocrinology	2023	Bioinformatic analysis confirms differences in circular RNA expression profiles of cumulus cells between patients with ovarian and peritoneal endometriosis-associated infertility.	hsa_circ_0005205		hsa_circ_HIF1A	HIF1A	peritoneal endometriosis-associated infertility	MONDO:0005133	endometriosis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005205 shows increased expression in cumulus cells from the PEM group compared with TFI by qRT-PCR, while not differing in OEM versus TFI. The study did not further characterize its mechanism or clinical relevance."	0.3588
37008951	Frontiers in endocrinology	2023	Bioinformatic analysis confirms differences in circular RNA expression profiles of cumulus cells between patients with ovarian and peritoneal endometriosis-associated infertility.	hsa_circ_0008927		hsa_circ_ATG7	ATG7	peritoneal endometriosis-associated infertility	MONDO:0005133	endometriosis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0008927 is marginally upregulated in cumulus cells from PEM versus TFI by qRT-PCR, but it does not significantly differ between PEM and OEM. The study did not further validate its mechanism or clinical utility."	0.3588
37009655	The EMBO journal	2023	CircPVT1 promotes ER-positive breast tumorigenesis and drug resistance by targeting ESR1 and MAVS.		circPVT1	hsa_circ_PVT1	PVT1	ER-positive breast cancer	MONDO:0006512	estrogen-receptor positive breast cancer	up-regulated	RT-qPCR; RNA-seq	"circPVT1 is up-regulated in breast cancer (including ERalpha-positive tumors) and promotes ERalpha-positive breast tumorigenesis and endocrine therapy resistance. Mechanistically, it sponges miR-181a-2-3p to increase ESR1/ERalpha signaling and directly binds MAVS to block RIGI_MAVS complex formation, suppressing type I IFN signaling and anti-tumor immunity; ASO-mediated circPVT1 inhibition suppresses tumor growth and re-sensitizes tamoxifen-resistant cells."	0.8785
37009655	The EMBO journal	2023	CircPVT1 promotes ER-positive breast tumorigenesis and drug resistance by targeting ESR1 and MAVS.		circPVT1	mmu_circ_PVT1	PVT1	ER-positive breast cancer	MONDO:0006512	estrogen-receptor positive breast cancer	up-regulated	RT-qPCR; RNA-seq	"circPVT1 is up-regulated in breast cancer (including ERalpha-positive tumors) and promotes ERalpha-positive breast tumorigenesis and endocrine therapy resistance. Mechanistically, it sponges miR-181a-2-3p to increase ESR1/ERalpha signaling and directly binds MAVS to block RIGI_MAVS complex formation, suppressing type I IFN signaling and anti-tumor immunity; ASO-mediated circPVT1 inhibition suppresses tumor growth and re-sensitizes tamoxifen-resistant cells."	0.8785
37009887	Respiratory research	2023	Downregulation of circ-YES1 suppresses NSCLC migration and proliferation through the miR-142-3p-HMGB1 axis.	hsa_circ_0046701	circ-YES1	hsa_circ_YES1	YES1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ-YES1 (hsa_circ_0046701), derived from the YES1 gene, is up-regulated in NSCLC cells and promotes proliferation, migration, and in vivo tumor growth/metastasis. Mechanistically, it functions as a ceRNA by sponging miR-142-3p to upregulate HMGB1, forming the circ-YES1/miR-142-3p/HMGB1 axis."	0.6536
37014625	Molecular oncology	2023	Circular RNA circ-TNRC6B inhibits the proliferation and invasion of esophageal squamous cell carcinoma cells by regulating the miR-452-5p/DAG1 axis.	hsa_circ_0063411	circ_TNRC6B	hsa_circ_TNRC6B	TNRC6B	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	RT-qPCR; ISH; RNA-seq	"circ-TNRC6B (hsa_circ_0063411), derived from TNRC6B exons 9_13, is down-regulated in ESCC tissues and serves as a tumor suppressor. It mainly localizes to the cytoplasm and acts as a ceRNA by sponging miR-452-5p, thereby relieving repression of DAG1 and inhibiting proliferation, migration, and invasion. Higher circ-TNRC6B expression is associated with better overall survival and is an independent protective prognostic factor."	0.879
37017121	Cancer science	2023	CircABCA13 acts as a miR-4429 sponge to facilitate esophageal squamous cell carcinoma development by stabilizing SRXN1.	hsa_circ_0001707	circABCA13	hsa_circ_ABCA13	ABCA13	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circABCA13 is overexpressed in ESCC and mainly localized in the cytoplasm, where it acts as a ceRNA by sponging miR-4429 to increase SRXN1 expression. This activates Wnt/beta-catenin signaling and promotes ESCC malignant phenotypes (proliferation, migration, invasion) and xenograft tumor growth, and high circABCA13 is associated with advanced stage and poor survival."	0.8909
37020267	BMC genomics	2023	Analysis and verification of the circRNA regulatory network RNO_CIRCpedia_ 4214/RNO-miR-667-5p/Msr1 axis as a potential ceRNA promoting macrophage M2-like polarization in spinal cord injury.		RNO_CIRCpedia_4214			spinal cord injury / SCI	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR; Microarray	"In a rat spinal cord injury model, RNO_CIRCpedia_4214 is implicated as a cytoplasmic ceRNA that binds rno-miR-667-5p, thereby positively regulating Msr1. Silencing RNO_CIRCpedia_4214 decreases Msr1/iNOS and increases miR-667-5p/Arg1, promoting macrophage polarization toward an M2-like phenotype."	0.7411
37020267	BMC genomics	2023	Analysis and verification of the circRNA regulatory network RNO_CIRCpedia_ 4214/RNO-miR-667-5p/Msr1 axis as a potential ceRNA promoting macrophage M2-like polarization in spinal cord injury.		RNO_CIRCpedia_9210	rno_circ_Diaph3	Diaph3	spinal cord injury / SCI	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR; Microarray	"RNO_CIRCpedia_9210 was identified as differentially expressed (up-regulated) in rat spinal cord tissue after SCI by microarray and its change was confirmed by RT-qPCR, but no downstream mechanism or function was characterized in this paper."	0.3213
37020267	BMC genomics	2023	Analysis and verification of the circRNA regulatory network RNO_CIRCpedia_ 4214/RNO-miR-667-5p/Msr1 axis as a potential ceRNA promoting macrophage M2-like polarization in spinal cord injury.		RNO_CIRCpedia_6416	rno_circ_Arhgap10	Arhgap10	spinal cord injury / SCI	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR; Microarray	RNO_CIRCpedia_6416 was reported as up-regulated in rat spinal cord after SCI in microarray data and this expression trend was confirmed by RT-qPCR; no functional mechanism was experimentally investigated for this circRNA in the study.	0.3213
37020267	BMC genomics	2023	Analysis and verification of the circRNA regulatory network RNO_CIRCpedia_ 4214/RNO-miR-667-5p/Msr1 axis as a potential ceRNA promoting macrophage M2-like polarization in spinal cord injury.		RNO_CIRCpedia_5663	rno_circ_Prmt8	Prmt8	spinal cord injury / SCI	MONDO:0043797	spinal cord injury	down-regulated	RT-qPCR; Microarray	RNO_CIRCpedia_5663 was found to be down-regulated in rat spinal cord after SCI by microarray and the trend was confirmed by RT-qPCR; the study did not further characterize its mechanism or functional role.	0.3213
37020690	International journal of nanomedicine	2023	Nanoparticles Mediated circROBO1 Silencing to Inhibit Hepatocellular Carcinoma Progression by Modulating miR-130a-5p/CCNT2 Axis.	hsa_circ_0066568	circROBO1	hsa_circ_ROBO1	ROBO1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circROBO1 (hsa_circ_0066568), derived from ROBO1, is upregulated in HCC and mainly localized in the cytoplasm. It promotes HCC proliferation and tumor growth by sponging miR-130a-5p, thereby upregulating CCNT2, and high circROBO1 predicts worse OS/RFS."	0.8768
37020694	The journal of venomous animals and toxins including tropical diseases	2023	Isoliquiritigenin regulates the circ_0002860/miR-431-5p/RAB9A axis to function as a tumor inhibitor in melanoma.	hsa_circ_0002860	circ_0002860	hsa_circ_CFLAR	CFLAR	melanoma	MONDO:0005105	melanoma	up-regulated	RT-qPCR	"In melanoma, circ_0002860 is upregulated and functions as an oncogenic circRNA by promoting proliferation, cell-cycle progression, migration/invasion and EMT while inhibiting apoptosis. ISL exerts antitumor effects partly by downregulating circ_0002860, which otherwise sponges miR-431-5p to upregulate RAB9A (circ_0002860/miR-431-5p/RAB9A ceRNA axis)."	0.8172
37026617	Cell transplantation	2023	circSOBP Inhibits Bladder Cancer Proliferation and Metastasis by Regulating the miR-200a-3p/PTEN Axis and Participating in the Immune Response.	hsa_circ_0001633	circSOBP	hsa_circ_SOBP	SOBP	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"circSOBP (hsa_circ_0001633) is down-regulated in bladder cancer and acts as a tumor suppressor by inhibiting proliferation, migration, invasion, tumor growth and metastasis. It primarily localizes to the cytoplasm and functions as a ceRNA by sponging miR-200a-3p to increase PTEN expression. Clinically, higher circSOBP is associated with better overall survival and may correlate with response to PD-1/PD-L1-based immunotherapy."	0.8889
37034720	bioRxiv : the preprint server for biology	2023	RNA landscapes of brain tissue and brain tissue-derived extracellular vesicles in simian immunodeficiency virus (SIV) infection and SIV-related central nervous system pathology.		circ-IFI6_0001		IFI6	SIV infection 	MONDO:0005108	viral infectious disease	dysregulated	RT-qPCR; RNA-seq	circ-IFI6_0001 is dysregulated in SIV-infected macaque brain homogenate and shows higher abundance in acute infection and chronic infection with CNS pathology (CP+). It is proposed to participate in ceRNA regulatory networks influencing bdEV miRNA/mRNA cargo and may have biomarker potential for SIV CNS infection.	0.6521
37034720	bioRxiv : the preprint server for biology	2023	RNA landscapes of brain tissue and brain tissue-derived extracellular vesicles in simian immunodeficiency virus (SIV) infection and SIV-related central nervous system pathology.		circ-EXOC2_0008		EXOC2	SIV infection 	MONDO:0005108	viral infectious disease	dysregulated	RT-qPCR; RNA-seq	circ-EXOC2_0008 is dysregulated in SIV-infected macaque brain homogenate and shows a disease-course-associated pattern opposite to circ-IFI6_0001. The study suggests it may have regulatory relevance and biomarker potential in SIV CNS infection.	0.6521
37034720	bioRxiv : the preprint server for biology	2023	RNA landscapes of brain tissue and brain tissue-derived extracellular vesicles in simian immunodeficiency virus (SIV) infection and SIV-related central nervous system pathology.		circ-PRKCE_0004		PRKCE	SIV infection 	MONDO:0005108	viral infectious disease	dysregulated	RT-qPCR; RNA-seq	circ-PRKCE_0004 is dysregulated in SIV-infected macaque brain and is highlighted as persistently dysregulated even during asymptomatic chronic infection (CP_). The study does not define a specific downstream miRNA/mRNA axis for this circRNA.	0.6521
37034720	bioRxiv : the preprint server for biology	2023	RNA landscapes of brain tissue and brain tissue-derived extracellular vesicles in simian immunodeficiency virus (SIV) infection and SIV-related central nervous system pathology.		circ-PPP2R5A_0001		PPP2R5A	SIV infection 	MONDO:0005108	viral infectious disease	dysregulated	RT-qPCR; RNA-seq	circ-PPP2R5A_0001 is dysregulated in SIV-infected macaque brain and is noted as persistently dysregulated even in asymptomatic chronic infection (CP_). No specific ceRNA partners are reported for this circRNA.	0.6521
37034720	bioRxiv : the preprint server for biology	2023	RNA landscapes of brain tissue and brain tissue-derived extracellular vesicles in simian immunodeficiency virus (SIV) infection and SIV-related central nervous system pathology.		circ-RNF41_0003		RNF41	SIV infection 	MONDO:0005108	viral infectious disease	dysregulated	RT-qPCR; RNA-seq	circ-RNF41_0003 is dysregulated in SIV-infected macaque brain and is noted as persistently dysregulated even in asymptomatic chronic infection (CP_). The study does not provide a specific ceRNA axis for this circRNA.	0.6521
37034720	bioRxiv : the preprint server for biology	2023	RNA landscapes of brain tissue and brain tissue-derived extracellular vesicles in simian immunodeficiency virus (SIV) infection and SIV-related central nervous system pathology.		circ-ENC1_0001		ENC1	SIV infection 	MONDO:0005108	viral infectious disease	dysregulated	RT-qPCR; RNA-seq	circ-ENC1_0001 is dysregulated in SIV-infected macaque brain and is implicated in predicted ceRNA networks that could modulate bdEV miRNA abundance during infection and CNS pathology. Specific miRNA targets for this circRNA are not named in the text provided.	0.6521
37035757	Mediators of inflammation	2023	circRNA_17725 Promotes Macrophage Polarization towards M2 by Targeting FAM46C to Alleviate Arthritis.		circRNA_17725			rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	down-regulated	RT-qPCR; RNA-seq	"circRNA_17725 is down-regulated in RA PBMCs/CD14+ monocytes and negatively correlates with disease activity. Functionally, its overexpression suppresses macrophage proliferation and inflammatory cytokine production, promotes apoptosis, and drives macrophage polarization toward M2 via the ceRNA axis circRNA_17725_miR-4668-5p_FAM46C, alleviating arthritis in CIA mice."	0.7421
37035757	Mediators of inflammation	2023	circRNA_17725 Promotes Macrophage Polarization towards M2 by Targeting FAM46C to Alleviate Arthritis.		circRNA_17725			rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	down-regulated	RT-qPCR; RNA-seq	"circRNA_17725 is down-regulated in RA PBMCs/CD14+ monocytes and negatively correlates with disease activity. Functionally, its overexpression suppresses macrophage proliferation and inflammatory cytokine production, promotes apoptosis, and drives macrophage polarization toward M2 via the ceRNA axis circRNA_17725_miR-4668-5p_FAM46C, alleviating arthritis in CIA mice."	0.7421
37039160	Cancer medicine	2023	CircFAM114A2 inhibits the progression of hepatocellular carcinoma via miR-630/HHIP axis.	hsa_circ_0007773	circFAM114A2	hsa_circ_FAM114A2	FAM114A2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"circFAM114A2 is down-regulated in HCC tissues and plasma and suppresses HCC cell proliferation, migration, and invasion while promoting apoptosis. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-630 to upregulate the tumor suppressor HHIP. Plasma circFAM114A2 shows diagnostic potential for distinguishing HCC patients from healthy controls."	0.8837
37041721	Cancer medicine	2023	CircPTPRA promotes the progression of pancreatic ductal adenocarcinoma via the miR-140-5p/LMNB1 axis.	hsa_circ_0006117	circPTPRA / hsa_circPTPRA_009	hsa_circ_PTPRA	PTPRA	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; ISH; Microarray	"CircPTPRA is up-regulated in PDAC tissues and cell lines and mainly localizes to the cytoplasm. It promotes PDAC proliferation, migration, invasion, tumor growth, and EMT by sponging miR-140-5p to increase LMNB1 expression (circPTPRA/miR-140-5p/LMNB1 axis). High circPTPRA expression is associated with lymph node invasion and poor prognosis in PDAC patients."	0.898
37046045	Oncogene	2023	Exosomal circSPIRE1 mediates glycosylation of E-cadherin to suppress metastasis of renal cell carcinoma.	hsa_circ_0000829	circSPIRE1	hsa_circ_SPIRE1	SPIRE1	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	down-regulated	RT-qPCR; Northern Blot; RNA-seq	"circSPIRE1 (hsa_circ_0000829), derived from SPIRE1, is downregulated in metastatic RCC and acts as a metastasis suppressor. It functions mainly as a cytoplasmic/exosomal RNA scaffold: binding ELAVL1 to enhance stabilization of GALNT3 and QKI mRNAs, thereby promoting E-cadherin glycosylation/membrane localization and maintaining an epithelial state; QKI feeds back to promote circSPIRE1 biogenesis. Exosomal circSPIRE1 also suppresses endothelial permeability and angiogenesis, and higher circSPIRE1 associates with better DFS."	0.8941
37046729	Cancers	2023	CircRNA RNA hsa_circ_0008234 Promotes Colon Cancer Progression by Regulating the miR-338-3p/ETS1 Axis and PI3K/AKT/mTOR Signaling.	hsa_circ_0008234	circFOXP1 / circ_hsa_0008234	hsa_circ_FOXP1	FOXP1	colon cancer	MONDO:0021063	malignant colon neoplasm	up-regulated	RT-qPCR; Microarray	"hsa_circ_0008234 (circFOXP1, from FOXP1) is up-regulated in colon cancer tissues/cell lines and promotes proliferation, invasion, migration, tumor growth and metastasis. Mechanistically, it mainly localizes in the cytoplasm and functions as a ceRNA sponge for miR-338-3p to upregulate ETS1, leading to activation of PI3K/AKT/mTOR signaling."	0.8207
37046838	Cancers	2023	Disequilibrium between BRCA1 and BRCA2 Circular and Messenger RNAs Plays a Role in Breast Cancer.		BRCA1 circRNAs	hsa_circ_BRCA1	BRCA1	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RNA-seq	"BRCA1-derived circRNAs show an overall decreased circRNA/mRNA ratio in breast tumor tissue compared with adjacent normal tissue, indicating a backsplicing/linear-splicing disequilibrium associated with breast cancer."	0.3991
37046838	Cancers	2023	Disequilibrium between BRCA1 and BRCA2 Circular and Messenger RNAs Plays a Role in Breast Cancer.		BRCA2 circRNAs	hsa_circ_BRCA2	BRCA2	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RNA-seq	"BRCA2-derived circRNAs show an overall decreased circRNA/mRNA ratio in breast tumor tissue compared with adjacent normal tissue, indicating a backsplicing/linear-splicing disequilibrium associated with breast cancer."	0.3991
37047838	International journal of molecular sciences	2023	Novel Insights into circRNA Saga Coming from Spermatozoa and Epididymis of HFD Mice.		circADAM10	mmu_circ_ADAM10	ADAM10	obesity	MONDO:0011122	obesity disorder	up-regulated	RT-qPCR; Microarray	circADAM10 is up-regulated in spermatozoa from HFD mice. The study links its increased biogenesis to enhanced FUS-associated backsplicing in HFD sperm and predicts a ceRNA network through specific miRNAs connected to oxidative-stress-related targets.	0.5135
37047838	International journal of molecular sciences	2023	Novel Insights into circRNA Saga Coming from Spermatozoa and Epididymis of HFD Mice.		circPCSK6	mmu_circ_PCSK6	PCSK6	obesity	MONDO:0011122	obesity disorder	down-regulated	RT-qPCR; Microarray	"circPCSK6 is down-regulated in HFD spermatozoa and shows reduced FUS-dependent enrichment in HFD epididymis, consistent with less efficient epididymal backsplicing. Bioinformatic predictions place circPCSK6 in an oxidative-stress-related ceRNA network via multiple miRNAs and downstream targets."	0.3858
37047838	International journal of molecular sciences	2023	Novel Insights into circRNA Saga Coming from Spermatozoa and Epididymis of HFD Mice.		circSMAD2	mmu_circ_SMAD2	SMAD2	obesity	MONDO:0011122	obesity disorder	down-regulated	RT-qPCR; Microarray	circSMAD2 is down-regulated in HFD spermatozoa and is part of a predicted ceRNA network related to sperm motility. Restoring circSMAD2 levels in HFD sperm via uptake of CTRL epididymal luminal fluid vesicles increases PLAG1 and improves sperm motility.	0.4474
37051377	Frontiers in aging neuroscience	2023	Construction and analysis of circular RNA-associated competing endogenous RNA network in the hippocampus of aged mice for the occurrence of postoperative cognitive dysfunction.	mmu_circ_0001231		mmu_circ_Focad	Focad	postoperative cognitive dysfunction / POCD	MONDO:0002602	central nervous system disorder	down-regulated	RT-qPCR; RNA-seq	mmu_circ_0001231 (Focad) is down-regulated in the hippocampus of aged mice with surgery-induced POCD and was validated by qRT-PCR in this study.	0.5618
37051377	Frontiers in aging neuroscience	2023	Construction and analysis of circular RNA-associated competing endogenous RNA network in the hippocampus of aged mice for the occurrence of postoperative cognitive dysfunction.	mmu_circ_0001427		mmu_circ_Limk1	Limk1	postoperative cognitive dysfunction / POCD	MONDO:0002602	central nervous system disorder	down-regulated	RT-qPCR; RNA-seq	"mmu_circ_0001427 (Limk1) is down-regulated in the hippocampus of aged mice after surgery and is predicted in the ceRNA network to bind mmu-miR-185-3p, thereby being linked to regulation of the target mRNA Kmt5c in POCD-related metabolic-process modules."	0.4851
37051377	Frontiers in aging neuroscience	2023	Construction and analysis of circular RNA-associated competing endogenous RNA network in the hippocampus of aged mice for the occurrence of postoperative cognitive dysfunction.	mmu_circ_0000114		mmu_circ_Mpzl1	Mpzl1	postoperative cognitive dysfunction / POCD	MONDO:0002602	central nervous system disorder	down-regulated	RT-qPCR; RNA-seq	mmu_circ_0000114 (Mpzl1) is down-regulated in POCD-model mouse hippocampus and is included in a neural-plasticity ceRNA subnetwork where it is predicted to interact with mmu-miR-665-3p linked to regulation of Dlg4 (PSD95).	0.4851
37051377	Frontiers in aging neuroscience	2023	Construction and analysis of circular RNA-associated competing endogenous RNA network in the hippocampus of aged mice for the occurrence of postoperative cognitive dysfunction.	mmu_circ_0001661		mmu_circ_Csmd1	Csmd1	postoperative cognitive dysfunction / POCD	MONDO:0002602	central nervous system disorder	up-regulated	RT-qPCR; RNA-seq	mmu_circ_0001661 (Csmd1) is up-regulated in the hippocampus of aged mice with surgery-induced POCD and was validated by qRT-PCR in this study.	0.4468
37051377	Frontiers in aging neuroscience	2023	Construction and analysis of circular RNA-associated competing endogenous RNA network in the hippocampus of aged mice for the occurrence of postoperative cognitive dysfunction.	mmu_circ_0000688				postoperative cognitive dysfunction / POCD	MONDO:0002602	central nervous system disorder	up-regulated	RNA-seq	"mmu_circ_0000688 is up-regulated in POCD-model mouse hippocampus and is placed in an oxygen/immune-response ceRNA subnetwork where it interacts with mmu-miR-5,114 and is linked to increased Ryr3 expression, potentially contributing to Ca2+ dyshomeostasis and neuroinflammation-related cognitive deficits."	0.31
37053191	PloS one	2023	Mapping CircRNA-miRNA-mRNA regulatory axis identifies hsa_circ_0080942 and hsa_circ_0080135 as a potential theranostic agents for SARS-CoV-2 infection.	hsa_circ_0080942		hsa_circ_PCLO	PCLO	SARS-CoV-2 infection / COVID-19	MONDO:0100096	COVID-19	dysregulated	RNA-seq	"This study computationally prioritizes hsa_circ_0080942 as a dysregulated circRNA in SARS-CoV-2 infection and places it in a cytokine-storm-focused ceRNA network. hsa_circ_0080942 is predicted to sponge multiple miRNAs (e.g., hsa-miR-1183, hsa-miR-486-3p) to modulate cytokine/chemokine mRNAs (e.g., IL1B, IL33, CXCL8, CXCL10), suggesting theranostic potential."	0.1768
37053191	PloS one	2023	Mapping CircRNA-miRNA-mRNA regulatory axis identifies hsa_circ_0080942 and hsa_circ_0080135 as a potential theranostic agents for SARS-CoV-2 infection.	hsa_circ_0080135		hsa_circ_TNS3	TNS3	SARS-CoV-2 infection / COVID-19	MONDO:0100096	COVID-19	dysregulated	RNA-seq	"This study computationally prioritizes hsa_circ_0080135 as a dysregulated circRNA in SARS-CoV-2 infection and integrates it into a cytokine-storm ceRNA network. hsa_circ_0080135 is predicted to sponge miRNAs (e.g., hsa-miR-885-3p, hsa-miR-769-3p) to regulate cytokine/chemokine mRNAs (e.g., IL12B, IL1B, IL33, CXCL10, IFNG), supporting potential theranostic relevance."	0.1768
37056143	Neural regeneration research	2023	"The circular RNA Rap1b promotes Hoxa5 transcription by recruiting Kat7 and leading to increased Fam3a expression, which inhibits neuronal apoptosis in acute ischemic stroke."		circRap1b / circular RNA Rap1b	mmu_circ_Rap1b	Rap1b	ischemic stroke / IS	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR	"In mouse and HT22 oxygen-glucose deprivation AIS models, circRap1b is down-regulated. circRap1b suppresses neuronal apoptosis by recruiting Kat7 to the Hoxa5 promoter to increase H3K14ac and activate Hoxa5 transcription, which upregulates Fam3a."	0.7541
37056926	International journal of biological sciences	2023	M6A-modified circRBM33 promotes prostate cancer progression via PDHA1-mediated mitochondrial respiration regulation and presents a potential target for ARSI therapy.	hsa_circ_0001771	circRBM33	hsa_circ_RBM33	RBM33	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; RNA-seq	"circRBM33 (hsa_circ_0001771) is up-regulated and m6A-modified in prostate cancer. It promotes proliferation, invasion, and xenograft tumour growth by forming an m6A-dependent complex with FMR1 that stabilizes PDHA1 mRNA and enhances mitochondrial respiration/oxidative phosphorylation. circRBM33 depletion improves sensitivity to ARSI therapy (enzalutamide/darolutamide) and high circRBM33 predicts worse BCR-free survival."	0.8794
37057923	Acta biochimica et biophysica Sinica	2023	Circular RNA hsa_circ_0007444 inhibits ovarian cancer progression through miR-23a-3p/DICER1 axis.	hsa_circ_0007444	circRHOBTB3 / circ_0007444	hsa_circ_RHOBTB3	RHOBTB3	ovarian cancer / OC	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR	"hsa_circ_0007444 is down-regulated in ovarian cancer tissues and cell lines and functions as a tumor suppressor. It mainly localizes to the cytoplasm, binds AGO2, sponges miR-23a-3p, and thereby increases DICER1 expression, leading to reduced proliferation/migration/invasion and enhanced apoptosis, as well as inhibited tumor growth and lung metastasis in vivo."	0.8443
37058537	PloS one	2023	Circular RNA expression alterations and function prediction in OSA-induced pancreatic injury in mice: New insights into pathogenesis.		mmu_circRNA_38000			obstructive sleep apnea / OSA	MONDO:0007147	obstructive sleep apnea syndrome	up-regulated	RT-qPCR; Microarray	"mmu_circRNA_38000 is up-regulated in pancreas of CIH (OSA-related) mice. It was included in a predicted ceRNA network suggesting dysregulated circRNAs may act as miRNA sponges to indirectly regulate mRNA targets, potentially involving MAPK-related signaling at the pathway-enrichment level."	0.3684
37058537	PloS one	2023	Circular RNA expression alterations and function prediction in OSA-induced pancreatic injury in mice: New insights into pathogenesis.		mmu_circRNA_015198			obstructive sleep apnea / OSA	MONDO:0007147	obstructive sleep apnea syndrome	up-regulated	RT-qPCR; Microarray	"mmu_circRNA_015198 is up-regulated in pancreas of CIH (OSA-related) mice. The study predicts it may act as a miRNA sponge within a circRNA_miRNA_mRNA ceRNA network, with candidate targets including mmu-let-7c-1-3p and mmu-miR-139-3p, thereby potentially influencing downstream gene regulation in CIH-induced pancreatic injury."	0.3684
37058537	PloS one	2023	Circular RNA expression alterations and function prediction in OSA-induced pancreatic injury in mice: New insights into pathogenesis.		mmu_circRNA_31565			obstructive sleep apnea / OSA	MONDO:0007147	obstructive sleep apnea syndrome	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_31565 is down-regulated in pancreas of CIH (OSA-related) mice. It was incorporated into a predicted circRNA_miRNA_mRNA ceRNA network, suggesting a potential role in indirectly regulating mRNA targets via miRNA sponging in CIH-induced pancreatic injury."	0.3684
37058537	PloS one	2023	Circular RNA expression alterations and function prediction in OSA-induced pancreatic injury in mice: New insights into pathogenesis.		mmu_circRNA_36426			obstructive sleep apnea / OSA	MONDO:0007147	obstructive sleep apnea syndrome	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_36426 is down-regulated in pancreas of CIH (OSA-related) mice. It was used to build a predicted circRNA_miRNA_mRNA ceRNA network, implying a possible role in miRNA sponging and downstream mRNA regulation in CIH-induced pancreatic injury."	0.3684
37058537	PloS one	2023	Circular RNA expression alterations and function prediction in OSA-induced pancreatic injury in mice: New insights into pathogenesis.		mmu_circRNA_39531			obstructive sleep apnea / OSA	MONDO:0007147	obstructive sleep apnea syndrome	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_39531 is down-regulated in pancreas of CIH (OSA-related) mice. It was among the circRNAs used to construct a predicted ceRNA network, indicating a potential role in miRNA-mediated regulation of downstream mRNAs in CIH-induced pancreatic injury."	0.3684
37058537	PloS one	2023	Circular RNA expression alterations and function prediction in OSA-induced pancreatic injury in mice: New insights into pathogenesis.		mmu_circRNA_36670			obstructive sleep apnea / OSA	MONDO:0007147	obstructive sleep apnea syndrome	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_36670 is down-regulated in pancreas of CIH (OSA-related) mice and was used to build a predicted circRNA_miRNA_mRNA network, suggesting a potential role in miRNA sponging and indirect regulation of mRNA targets during CIH-induced pancreatic injury."	0.3684
37065234	Frontiers in veterinary science	2023	RNA sequencing reveals CircRNA expression profiles in chicken embryo fibroblasts infected with velogenic Newcastle disease virus.		circ-EZH2 / novel_circ_005418	gga_circ_EZH2	EZH2	velogenic Newcastle disease virus infection / NDV infection	MONDO:0005108	viral infectious disease	up-regulated	RT-qPCR; RNA-seq	"circ-EZH2 (novel_circ_005418) is up-regulated in NDV-infected chicken embryo fibroblasts and functions as an antiviral factor: overexpression suppresses, while knockdown enhances, NDV replication. The study predicts a circRNA_miRNA_mRNA network in which circ-EZH2 may bind gga-miR-1a-3p, gga-miR-34c-3p and miR-34-y to influence downstream target genes and antiviral-related pathways."	0.6291
37065234	Frontiers in veterinary science	2023	RNA sequencing reveals CircRNA expression profiles in chicken embryo fibroblasts infected with velogenic Newcastle disease virus.		novel_circ_003546	gga_circ_LPAR1	LPAR1	velogenic Newcastle disease virus infection / NDV infection	MONDO:0005108	viral infectious disease	up-regulated	RT-qPCR; RNA-seq	"novel_circ_003546 (host gene LPAR1) is up-regulated in NDV-infected chicken embryo fibroblasts and was experimentally validated as a circular RNA by divergent-primer PCR, RNase R resistance, and Sanger sequencing; no specific functional mechanism was characterized beyond differential expression."	0.4566
37065234	Frontiers in veterinary science	2023	RNA sequencing reveals CircRNA expression profiles in chicken embryo fibroblasts infected with velogenic Newcastle disease virus.		novel_circ_002830	gga_circ_RNF13	RNF13	velogenic Newcastle disease virus infection / NDV infection	MONDO:0005108	viral infectious disease	up-regulated	RT-qPCR; RNA-seq	"novel_circ_002830 (host gene RNF13) is up-regulated in NDV-infected chicken embryo fibroblasts and was experimentally validated as a circular RNA by divergent-primer PCR, RNase R resistance, and Sanger sequencing; no specific functional mechanism was characterized beyond differential expression."	0.4566
37065234	Frontiers in veterinary science	2023	RNA sequencing reveals CircRNA expression profiles in chicken embryo fibroblasts infected with velogenic Newcastle disease virus.		novel_circ_000636	gga_circ_ERK	ERK	velogenic Newcastle disease virus infection / NDV infection	MONDO:0005108	viral infectious disease	down-regulated	RT-qPCR; RNA-seq	"novel_circ_000636 (host gene ERK) is down-regulated in NDV-infected chicken embryo fibroblasts and was experimentally validated as a circular RNA by divergent-primer PCR, RNase R resistance, and Sanger sequencing; no specific functional mechanism was characterized beyond differential expression."	0.4566
37065234	Frontiers in veterinary science	2023	RNA sequencing reveals CircRNA expression profiles in chicken embryo fibroblasts infected with velogenic Newcastle disease virus.		novel_circ_001830	gga_circ_BANP	BANP	velogenic Newcastle disease virus infection / NDV infection	MONDO:0005108	viral infectious disease	down-regulated	RT-qPCR; RNA-seq	"novel_circ_001830 (host gene BANP) is down-regulated in NDV-infected chicken embryo fibroblasts and was experimentally validated as a circular RNA by divergent-primer PCR, RNase R resistance, and Sanger sequencing; no specific functional mechanism was characterized beyond differential expression."	0.4566
37066229	bioRxiv : the preprint server for biology	2023	Circular RNAs in the human brain are tailored to neuron identity and neuropsychiatric disease.		circDNAJC6	hsa_circ_DNAJC6	DNAJC6	Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	dysregulated	RT-qPCR; RNA-seq	"circDNAJC6 is aberrantly expressed in prodromal/early Parkinson¡¯s disease-related Lewy body neuropathology in dopamine neurons, while linear DNAJC6 mRNA is not altered. The study validates its neuronal expression using qPCR with RNase R treatment."	0.5135
37066229	bioRxiv : the preprint server for biology	2023	Circular RNAs in the human brain are tailored to neuron identity and neuropsychiatric disease.		circPSEN1	hsa_circ_PSEN1	PSEN1	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	unknown	RT-qPCR; RNA-seq	"circPSEN1-2 is a PSEN1-derived circRNA from a familial Alzheimer¡¯s disease locus, and its circular nature/expression in brain regions was confirmed by RNase R treatment followed by qPCR. The paper does not report a disease-associated up/down direction for circPSEN1-2."	0.4773
37066229	bioRxiv : the preprint server for biology	2023	Circular RNAs in the human brain are tailored to neuron identity and neuropsychiatric disease.		circERC1-1	hsa_circ_ERC1	ERC1	Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	unknown	RT-qPCR; RNA-seq	"circERC1-1 is an ERC1-derived circRNA with dopamine neuron-preferential expression in human brain, validated by RNase R plus qPCR in substantia nigra vs temporal cortex. The study does not establish a specific disease-direction change for circERC1-1."	0.4773
37066229	bioRxiv : the preprint server for biology	2023	Circular RNAs in the human brain are tailored to neuron identity and neuropsychiatric disease.		circERC1-2	hsa_circ_ERC1	ERC1	Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	unknown	RT-qPCR; RNA-seq	"circERC1-2 is an ERC1-derived circRNA with pyramidal neuron/temporal cortex-preferential expression relative to substantia nigra, supported by RNase R plus qPCR. The study does not establish a specific disease-direction change for circERC1-2."	0.4773
37070251	Clinical and translational medicine	2023	O-GlcNAcylated LARP1 positively regulated by circCLNS1A facilitates hepatoblastoma progression through DKK4/beta-catenin signalling.		circCLNS1A	hsa_circ_CLNS1A	CLNS1A	hepatoblastoma / HB	MONDO:0018666	hepatoblastoma	unknown	RT-qPCR	"In hepatoblastoma, circCLNS1A binds to O-GlcNAcylated LARP1 and stabilizes LARP1 protein by antagonizing TRIM-25-mediated ubiquitination. This sustains the LARP1/DKK4/beta-catenin cascade and promotes malignant phenotypes such as proliferation and tumor growth while inhibiting apoptosis."	0.763
37073425	Thoracic cancer	2023	Downregulation of circ_PLXND1 inhibits tumorigenesis of non-small cell lung carcinoma via miR-1287-5p/ERBB3 axis.	hsa_circ_0067301	circ_PLXND1	hsa_circ_PLXND1	PLXND1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circ_PLXND1 is up-regulated in NSCLC tissues and cell lines and mainly localizes to the cytoplasm. It promotes malignant phenotypes (proliferation, angiogenesis, migration, invasion and tumor growth) and inhibits apoptosis by sponging miR-1287-5p to upregulate ERBB3."	0.7955
37079240	Environmental science and pollution research international	2023	EIF4A3-induced circular RNA SCAP facilitates tumorigenesis and progression of non-small-cell lung cancer via miR-7/SMAD2 signaling.		Circular RNA SCAP / circSCAP	hsa_circ_SCAP	SCAP	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circSCAP is up-regulated in NSCLC tissues and cell lines and mainly localizes to the cytoplasm. It promotes NSCLC cell proliferation, migration and invasion by acting as a ceRNA that sponges miR-7, thereby de-repressing SMAD2; its high expression is associated with worse overall survival."	0.8625
37082696	Annals of translational medicine	2023	"CircRBM33 promotes migration, invasion and mediates osimertinib resistance in non-small cell lung cancer cell line."	hsa_circ_0001772	circRBM33	hsa_circ_RBM33	RBM33	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"CircRBM33 (hsa_circ_0001772; host gene RBM33) is upregulated in NSCLC models of osimertinib resistance (H1975-OR). Its knockdown suppresses proliferation, migration/invasion, tumor growth and drug resistance while promoting apoptosis, potentially by binding DNMT1 and influencing the DNMT1/IL-6 axis."	0.6742
37082735	International journal of medical sciences	2023	Transcriptomic Profiling of circRNAs in rat Hippocampus after Deep Hypothermic Circulatory Arrest.	rno_circ_0028462	rno_circRNA_0028462	rno_circ_Frrs1	Frrs1	DHCA-related cerebral injury	MONDO:0005299	brain ischemia	up-regulated	RT-qPCR; RNA-seq	"rno_circ_0028462 is up-regulated in rat hippocampus after DHCA. The study predicts it may function as a miRNA sponge within a circRNA_miRNA interaction network, including binding miR-27a-3p, but downstream targets were not experimentally validated."	0.5608
37082735	International journal of medical sciences	2023	Transcriptomic Profiling of circRNAs in rat Hippocampus after Deep Hypothermic Circulatory Arrest.	rno_circ_0037165	rno_circRNA_0037165	rno_circ_Plxna4	Plxna4	DHCA-related cerebral injury	MONDO:0005299	brain ischemia	up-regulated	RT-qPCR; RNA-seq	"rno_circ_0037165 is up-regulated in rat hippocampus after DHCA. It was included in a predicted circRNA_miRNA interaction network and is suggested to sponge let-7 family miRNAs, but downstream effects were not experimentally validated."	0.5608
37082735	International journal of medical sciences	2023	Transcriptomic Profiling of circRNAs in rat Hippocampus after Deep Hypothermic Circulatory Arrest.	rno_circ_0045161	rno_circRNA_0045161	rno_circ_Atl1	Atl1	DHCA-related cerebral injury	MONDO:0005299	brain ischemia	down-regulated	RT-qPCR; RNA-seq	"rno_circ_0045161 is down-regulated in rat hippocampus after DHCA. The study predicts it may act as a miRNA sponge (e.g., miR-10b-3p, miR-23a-5p and let-7 family) within a constructed circRNA_miRNA network, without experimental validation of downstream targets."	0.5608
37082735	International journal of medical sciences	2023	Transcriptomic Profiling of circRNAs in rat Hippocampus after Deep Hypothermic Circulatory Arrest.	rno_circ_0019047	rno_circRNA_0019047	rno_circ_Sf3b3	Sf3b3	DHCA-related cerebral injury	MONDO:0005299	brain ischemia	down-regulated	RT-qPCR; RNA-seq	"rno_circ_0019047 is down-regulated in rat hippocampus after DHCA and was included as one of four RT-qPCR-validated circRNAs. It was used to build a predicted circRNA_miRNA interaction network, but specific interacting miRNAs and functional effects were not reported in the text provided."	0.5608
37085748	BMC genomics	2023	Comprehensive analysis of circular RNAs in porcine small intestine epithelial cells associated with susceptibility to Escherichia coli F4ac diarrhea.		circ-SORBS1	ssc_circ_SORBS1	SORBS1	Escherichia coli F4ac diarrhea	MONDO:0020920	escherichia coli infection	unknown	RNA-seq	"circ-SORBS1 is a differentially expressed circRNA associated with piglet susceptibility to ETEC-F4ac diarrhea and is higher in the adhesive (susceptible) group. It may act as a ceRNA by sponging ssc-miR-345-3p to regulate its host gene SORBS1, thereby promoting epithelial cell adhesion; it may also target ssc-miR-122-5p to affect other diarrhea-related genes."	0.1768
37087475	Molecular cancer	2023	A novel protein encoded by circINSIG1 reprograms cholesterol metabolism by promoting the ubiquitin-dependent degradation of INSIG1 in colorectal cancer.	hsa_circ_0133744	circINSIG1	hsa_circ_INSIG1	INSIG1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circINSIG1 (hsa_circ_0133744) is upregulated in colorectal cancer and mainly localized in the cytoplasm. It encodes a 121-aa peptide (circINSIG1-121) that recruits the CUL5-ASB6 E3 ligase complex to enhance K48-linked ubiquitination and proteasomal degradation of INSIG1, thereby activating SREBP2-driven cholesterol biosynthesis and promoting CRC proliferation and metastasis; high circINSIG1 associates with advanced stage and poor survival."	0.8978
37090082	Experimental and therapeutic medicine	2023	Combination of hsa_circ_0004674 and lncRNA OIP5_AS1 as a novel clinical biomarker used to predict prognosis in patients with osteosarcoma.	hsa_circ_0004674				osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"In 20 conventional osteosarcoma patients, hsa_circ_0004674 was significantly upregulated in tumor tissue and serum. Higher serum hsa_circ_0004674 was associated with lung metastasis, chemoresistance, and worse progression-free survival, supporting its use (alone and combined with OIP5-AS1) as a clinical biomarker."	0.4758
37092305	Epigenetics	2023	m6A-modification regulated circ-CCT3 acts as the sponge of miR-378a-3p to promote hepatocellular carcinoma progression.	hsa_circ_0004680	circ-CCT3 / circ_0004680	hsa_circ_CCT3	CCT3	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circ-CCT3 (hsa_circ_0004680), derived from CCT3, is up-regulated in HCC and predicts poor prognosis. It promotes HCC proliferation, migration/invasion, angiogenesis and in vivo tumor growth/metastasis mainly by sponging miR-378a-3p to increase FLT1, and its level is regulated via m6A-related factors including ALKBH5 and METTL3."	0.8869
37096660	The Kaohsiung journal of medical sciences	2023	CircHECTD1 promoted MIRI-associated inflammation via inhibiting miR-138-5p and upregulating ROCK2.		circHECTD1 / CircRNA HECTD1	rno_circ_HECTD1	HECTD1	myocardial ischemia/reperfusion injury	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR	"circHECTD1 is up-regulated in rat myocardial ischemia_reperfusion injury and in H/R-treated H9c2 cells. It promotes inflammatory cytokine production and apoptosis by sponging miR-138-5p, thereby increasing ROCK2 expression (circHECTD1/miR-138-5p/ROCK2 ceRNA axis)."	0.6578
37101128	Cellular & molecular biology letters	2023	CircRNF10-DHX15 interaction suppressed breast cancer progression by antagonizing DHX15-NF-kappaB p65 positive feedback loop.		circRNF10 / hsa_circRNA_101175	hsa_circ_RNF10	RNF10	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; RNA-seq	"circRNF10 is down-regulated in breast cancer and acts as a tumor suppressor. It binds the RBP DHX15 in the cytoplasm, competitively weakening DHX15_NF-kappaB p65 interaction to inhibit NF-kappaB signaling and disrupt the DHX15_p65 positive feedback loop, thereby reducing proliferation/migration and suppressing xenograft growth."	0.8988
37101395	Molecular therapy : the journal of the American Society of Gene Therapy	2023	Circular MTHFD2L RNA-encoded CM-248aa inhibits gastric cancer progression by targeting the SET-PP2A interaction.	hsa_circ_0069982	CircMTHFD2L	hsa_circ_MTHFD2L	MTHFD2L	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Northern Blot; RNA-seq	circMTHFD2L (hsa_circ_0069982) is downregulated in gastric cancer and mainly localized in the cytoplasm. Its biological impact in this study is primarily through encoding the peptide CM-248aa; restoring circMTHFD2L RNA without CM-248aa translation does not reverse malignant phenotypes.	0.6334
37102653	"Immunity, inflammation and disease"	2023	Mmu_circ_0000037 inhibits the progression of acute pancreatitis by miR-92a-3p/Pias1 axis.	mmu_circ_0000037		mmu_circ_Mfsd6	Mfsd6	acute pancreatitis / AP	MONDO:0006515	acute pancreatitis	down-regulated	RT-qPCR	"In a caerulein-induced acute pancreatitis cellular model (MPC-83), mmu_circ_0000037 is down-regulated and its overexpression attenuates cell injury by reducing amylase activity, apoptosis, and inflammatory cytokine release. Mechanistically, it sponges miR-92a-3p to de-repress Pias1 (mmu_circ_0000037/miR-92a-3p/Pias1)."	0.7394
37102659	"Immunity, inflammation and disease"	2023	CircSmox knockdown alleviates PC12 cell apoptosis and inflammation in spinal cord injury by miR-340-5p/Smurf1 axis.		circSmox / rno_Smox_0001	rno_circ_Smox	Smox	spinal cord injury / SCI	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR	"In an LPS-induced PC12 cell model relevant to SCI secondary injury, circSmox is up-regulated and promotes apoptosis and inflammatory cytokine production. circSmox acts as a ceRNA that sponges miR-340-5p, thereby increasing Smurf1 expression; inhibiting miR-340-5p or overexpressing Smurf1 counteracts the protective effects of circSmox knockdown."	0.7609
37105934	Thoracic cancer	2023	CircRNA ZKSCAN1 promotes lung adenocarcinoma progression by miR-185-5p/TAGLN2 axis.		Circ_ZKSCAN1	hsa_circ_ZKSCAN1	ZKSCAN1	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"Circ_ZKSCAN1 is up-regulated in LUAD, especially in cisplatin (DDP)-resistant tissues/cells, and promotes malignant phenotypes and DDP resistance. Mechanistically, it sponges miR-185-5p to indirectly increase TAGLN2, enhancing glycolysis and tumor growth and reducing apoptosis, including in xenograft models."	0.8001
37105940	Thoracic cancer	2023	Propofol mediates non-small cell lung cancer growth in part by regulating circ_0003028-related mechanisms.	hsa_circ_0003028	circ_0003028	hsa_circ_FUT8	FUT8	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0003028 is up-regulated in NSCLC tissues and cell lines and promotes malignant phenotypes. Propofol suppresses NSCLC growth partly by downregulating circ_0003028, which functions as a ceRNA to sponge miR-1305 and thereby increase CORO1C expression."	0.7856
37106826	Biology	2023	Whole-Transcriptome Analysis of Repeated Low-Level Sarin-Exposed Rat Hippocampus and Identification of Cerna Networks to Investigate the Mechanism of Sarin-Induced Cognitive Impairment.		Circ_Fmn1 / Circ Fmn1	rno_circ_Fmn1	Fmn1	sarin-induced cognitive impairment	MONDO:0002039	cognitive disorder	up-regulated	RNA-seq	"Circ_Fmn1 is up-regulated in the hippocampus after repeated low-level sarin exposure (recovery phase) and is a core node of the constructed ceRNA network. It likely sponges miR-741-3p/miR-764-3p/miR-871-3p to increase synaptic-plasticity-related targets (e.g., KIF1A, PTPN11, SYN1, MT-CO3), contributing to cognitive impairment."	0.1768
37106826	Biology	2023	Whole-Transcriptome Analysis of Repeated Low-Level Sarin-Exposed Rat Hippocampus and Identification of Cerna Networks to Investigate the Mechanism of Sarin-Induced Cognitive Impairment.		Circ_Cacna1c	rno_circ_Cacna1c	Cacna1c	sarin-induced cognitive impairment	MONDO:0002039	cognitive disorder	down-regulated	RNA-seq	"Circ_Cacna1c is down-regulated in the hippocampus after repeated low-level sarin exposure (recovery phase) and forms a core ceRNA circuit. Its decrease is associated with increased miR-10b-5p/miR-18a-5p and reduced targets (CACNA1C, PRKCD, RASGRP1), potentially impairing synaptic plasticity and contributing to cognitive dysfunction."	0.1768
37113397	Oncology letters	2023	Prognostic value of circWWC3 as a novel survival_related biomarker for clear cell renal cell carcinoma.		circWWC3	hsa_circ_WWC3	WWC3	clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	up-regulated	ISH	"circWWC3 is up-regulated in ccRCC tumor tissues and is mainly detected in the cytoplasm by FISH. High circWWC3 expression correlates with advanced T stage/pathological grade and independently predicts shorter overall survival, supporting its potential as a prognostic biomarker in ccRCC."	0.4758
37118847	Journal of translational medicine	2023	Circular RNA EPHA3 suppresses progression and metastasis in prostate cancer through the miR-513a-3p/BMP2 axis.	hsa_circ_0066596	circEPHA3	hsa_circ_EPHA3	EPHA3	prostate cancer / PCa	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; Microarray	"circEPHA3 is down-regulated in high-grade prostate cancer and aggressive PCa cell lines. It acts as a tumor suppressor by sponging miR-513a-3p to relieve repression of BMP2, thereby inhibiting proliferation and metastasis in vitro and in vivo."	0.8297
37132052	Thoracic cancer	2023	Circ_0001387 regulates SKA2 to accelerate breast cancer progression through miR-136-5p.	hsa_circ_0001387	circ_0001387	hsa_circ_WHSC1	WHSC1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0001387 is up-regulated in breast cancer tissues and cell lines and promotes malignant phenotypes (proliferation, migration/invasion) while inhibiting apoptosis. Mechanistically, it sponges miR-136-5p, thereby relieving repression of SKA2 and promoting tumor growth in a cell line-derived xenograft model; high circ_0001387 correlates with poorer prognosis."	0.8592
37137710	Thoracic cancer	2023	Circular RNA-mediated ceRNA network was identified in human lung adenocarcinoma by high-throughput sequencing.	hsa_circ_0120106				lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0120106 is significantly down-regulated in LUAD tissues and shows strong diagnostic potential by ROC analysis (AUC 0.949). The study constructs a predicted circRNA_miRNA_mRNA ceRNA network for LUAD, and notes prior literature that hsa_circ_0120106 can recruit TGFB1I1."	0.5047
37137710	Thoracic cancer	2023	Circular RNA-mediated ceRNA network was identified in human lung adenocarcinoma by high-throughput sequencing.	hsa_circ_0007342				lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; RNA-seq	has_circ_0007342 (also written as hsa_circ_0007342) is significantly down-regulated in LUAD tissues and shows high diagnostic value by ROC analysis (AUC 0.939). The study includes it in a predicted circRNA_miRNA_mRNA ceRNA network for LUAD.	0.5047
37137710	Thoracic cancer	2023	Circular RNA-mediated ceRNA network was identified in human lung adenocarcinoma by high-throughput sequencing.	hsa_circ_0005937				lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; RNA-seq	has_circ_0005937 (also written as hsa_circ_0005937) is significantly down-regulated in LUAD tissues and shows strong diagnostic performance in ROC analysis (AUC 0.913). It is included in the study¡¯s predicted circRNA_miRNA_mRNA ceRNA network for LUAD.	0.5047
37137710	Thoracic cancer	2023	Circular RNA-mediated ceRNA network was identified in human lung adenocarcinoma by high-throughput sequencing.	hsa_circ_0001640	circRNA_0001640			lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; RNA-seq	circRNA_0001640 (also reported as hsa_circ_0001640) is significantly down-regulated in LUAD tissues and shows diagnostic potential (AUC 0.934) by ROC analysis. It is part of the study¡¯s predicted circRNA_miRNA_mRNA ceRNA network in LUAD.	0.5047
37137884	Nature communications	2023	Identification of CircRNA signature associated with tumor immune infiltration to predict therapeutic efficacy of immunotherapy.		circTMTC3	hsa_circ_TMTC3	TMTC3	melanoma	MONDO:0005105	melanoma	up-regulated	RT-qPCR; RNA-seq	"In ICB-treated melanoma, circTMTC3 is upregulated in non-responders and its higher expression associates with worse PFS. Functionally, circTMTC3 overexpression suppresses hsa-miR-142-5p, increases PD-L1, reduces T-cell cytotoxicity, and promotes immune escape."	0.8082
37137884	Nature communications	2023	Identification of CircRNA signature associated with tumor immune infiltration to predict therapeutic efficacy of immunotherapy.		circFAM117B	hsa_circ_FAM117B	FAM117B	melanoma	MONDO:0005105	melanoma	up-regulated	RT-qPCR; RNA-seq	"In ICB-treated melanoma, circFAM117B is upregulated in non-responders and its higher expression associates with worse PFS. Functionally, circFAM117B overexpression suppresses hsa-miR-142-5p, increases PD-L1, reduces T-cell cytotoxicity, and promotes immune escape."	0.8082
37144575	CNS neuroscience & therapeutics	2023	Downregulation of ciRNA-Kat6b in dorsal spinal horn is required for neuropathic pain by regulating Kcnk1 in miRNA-26a-dependent manner.		ciRNA-Kat6b / circRNA Kat6b	mmu_circ_Kat6b		neuropathic pain	MONDO:0021667	neuralgia	down-regulated	RT-qPCR; RNA-seq	"In mouse neuropathic pain models (e.g., CCI), ciRNA-Kat6b is down-regulated in the ipsilateral dorsal spinal horn. ciRNA-Kat6b functions as a ceRNA sponge for miRNA-26a, thereby modulating miRNA-26a-mediated repression/degeneration of Kcnk1 mRNA and reducing KCNK1 protein, which contributes to pain hypersensitivity; restoring ciRNA-Kat6b alleviates neuropathic pain behaviors."	0.8324
37149637	Journal of orthopaedic surgery and research	2023	"Circ_0002984 promotes proliferation, migration and inflammatory cytokine secretion and inhibits apoptosis of rheumatoid arthritis fibroblast-like synoviocytes by inducing PCSK6 through miR-543."	hsa_circ_0002984	circ_0002984	hsa_circ_ARHGAP32	ARHGAP32	Rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"circ_0002984 is up-regulated in RA synovial tissues and MH7A RAFLSs. It promotes RAFLS proliferation, migration and TNF-alpha/IL-1beta secretion and suppresses apoptosis by sponging miR-543, thereby increasing PCSK6 expression."	0.7799
37150844	Annals of clinical and translational neurology	2023	Exosomal circ-AHCY promotes glioblastoma cell growth via Wnt/beta-catenin signaling pathway.	hsa_circ_0059914	circ_AHCY	hsa_circ_AHCY	AHCY	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; RNA-seq	"In glioblastoma, circ-AHCY (hsa_circ_0059914) is up-regulated and promotes proliferation and tumor growth while inhibiting apoptosis. It activates Wnt/beta-catenin signaling by sponging miR-1294 to increase MYC and thereby enhance CTNNB1 transcription, and it also recruits EIF4A3 to stabilize TCF4 mRNA, forming a positive feedback loop with the TCF4/beta-catenin complex. GBM cell-derived exosomal circ-AHCY can be transferred to normal human astrocytes and stimulate their proliferation."	0.8469
37151387	Journal of Cancer	2023	CircREOS suppresses lipid synthesis and osteosarcoma progression through inhibiting HuR-mediated MYC activation.	hsa_circ_0085535	circREOS	hsa_circ_MYC	MYC	osteosarcoma / OS	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR	"circREOS (hsa_circ_0085535), a MYC-derived circRNA, is down-regulated and mainly nuclear in osteosarcoma cells. It suppresses MYC expression by binding HuR and limiting HuR-mediated activation/stabilization of MYC mRNA, thereby reducing FASN-driven lipid accumulation and inhibiting OS cell proliferation and invasion."	0.7986
37155429	Journal of inflammation research	2023	Expression Profile of Pyroptosis-Related Genes and the Associated Regulatory Axis in Primary Gout Patients.		hsa_circRNA_102906 			primary gout / gout	MONDO:0005393	gout	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_102906 is up-regulated in PBMCs of primary gout patients. It is proposed to act as a ceRNA (miRNA sponge) for miR-129-5p, thereby affecting PRGs including DDX3X, NLRP3 and NLRP9, and shows diagnostic value by ROC analysis."	0.5047
37155429	Journal of inflammation research	2023	Expression Profile of Pyroptosis-Related Genes and the Associated Regulatory Axis in Primary Gout Patients.		hsa_circRNA_102910			primary gout / gout	MONDO:0005393	gout	up-regulated	RT-qPCR; Microarray	hsa_circRNA_102910 is up-regulated in PBMCs of primary gout patients. It is proposed to sponge miR-129-5p and thereby influence PRGs (DDX3X/NLRP3/NLRP9) within a circRNA_miRNA_mRNA ceRNA network; it also shows diagnostic value (AUC 0.766).	0.5047
37155429	Journal of inflammation research	2023	Expression Profile of Pyroptosis-Related Genes and the Associated Regulatory Axis in Primary Gout Patients.		hsa_circRNA_102911			primary gout / gout	MONDO:0005393	gout	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_102911 is up-regulated in PBMCs of primary gout patients. The study proposes a ceRNA axis in which it sponges miR-129-5p to regulate PRGs (DDX3X/NLRP3/NLRP9), and it correlates with inflammatory indices and may serve as a diagnostic biomarker (AUC 0.85)."	0.5047
37160403	Thoracic cancer	2023	"Hsa_circ_0002496 promotes the growth, angiogenesis, and stemness of breast cancer cells via miR-433-3p/YWHAZ cascade."	hsa_circ_0002496	Circ_0002496	hsa_circ_APPBP2	APPBP2	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0002496 is up-regulated in breast cancer tissues and cells and promotes malignant behaviors (proliferation/growth, angiogenesis, stemness) while inhibiting apoptosis. Mechanistically, it sponges miR-433-3p to increase YWHAZ and activate PI3K/AKT signaling, and its knockdown suppresses xenograft tumor growth."	0.7595
37160894	Cell death discovery	2023	Hsa_circ_0060467 promotes breast cancer liver metastasis by complexing with eIF4A3 and sponging miR-1205.	hsa_circ_0060467	circMYBL2	hsa_circ_MYBL2	MYBL2	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circMYBL2 (hsa_circ_0060467) is up-regulated in BCLM tissues and BC cells and promotes BC proliferation, migration, tumor growth, and liver metastasis. It sponges miR-1205 and recruits eIF4A3 to increase E2F1 (including via stabilizing E2F1 mRNA), thereby promoting EMT."	0.8266
37162666	Journal of neuro-oncology	2023	Translation of circHGF RNA encodes an HGF protein variant promoting glioblastoma growth through stimulation of c-MET.	hsa_circ_0080914	circ-HGF / Circular-HGF	hsa_circ_HGF	HGF	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; Northern Blot; RNA-seq	"circ-HGF (hsa_circ_0080914) is up-regulated in glioblastoma and localizes mainly to the cytoplasm. It is IRES-translated into a secreted peptide/protein variant (C-HGF) that binds and activates c-MET, stimulating downstream STAT3/AKT/ERK signaling to promote GBM proliferation, migration/invasion and intracranial xenograft tumor growth."	0.8769
37166441	Epigenetics	2023	Circ_0003747 promotes thyroid cancer progression by sponging miR-338-3p to upregulate PLCD3 expression.	hsa_circ_0003747	Circ_0003747 / circ 0003747	hsa_circ_CARF	CARF	thyroid carcinoma / TC	MONDO:0015075	thyroid gland carcinoma	up-regulated	RT-qPCR	"circ_0003747 is up-regulated in thyroid carcinoma cell lines and promotes malignant behaviors (proliferation, migration, invasion) while inhibiting apoptosis. Mechanistically, it functions as a ceRNA sponge for miR-338-3p, thereby relieving repression of PLCD3 and promoting tumor growth in a TPC-1 xenograft model."	0.7597
37170152	Journal of experimental & clinical cancer research : CR	2023	Exploring circular MET RNA as a potential biomarker in tumors exhibiting high MET activity.	hsa_circ_0082002	circMET / hsa-MET_000001	hsa_circ_MET	MET	cancer	MONDO:0004992	cancer	up-regulated	RT-qPCR; Northern Blot	"This study identifies circMET (hsa_circ_0082002), a MET exon 2-derived circRNA, and shows it is increased in high-MET tumors. circMET levels correlate with MET expression/activity and MET amplification, enabling non-invasive patient stratification and longitudinal monitoring of MET-driven acquired resistance and response to anti-MET therapies via plasma cfRNA."	0.8124
37173608	Discover oncology	2023	Myc derived circRNA promotes triple-negative breast cancer progression via reprogramming fatty acid metabolism.	hsa_circ_0085533	circMyc	hsa_circ_Myc	Myc	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"circMyc (hsa_circ_0085533) is up-regulated in TNBC and promotes proliferation, invasion, lipogenesis and tumor growth. Mechanistically, cytoplasmic circMyc binds HuR to stabilize SREBP1 mRNA, while nuclear circMyc binds Myc to enhance Myc occupancy at the SREBP1 promoter and increase SREBP1 transcription, driving fatty acid metabolism reprogramming."	0.8669
37173768	Journal of orthopaedic surgery and research	2023	Circ_0005615 restrains the progression of multiple myeloma through modulating miR-331-3p and IGF1R regulatory cascade.	hsa_circ_0005615	circ_0005615 / hsa_circRNA_101835			multiple myeloma / MM	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR	"circ_0005615 is up-regulated in multiple myeloma bone marrow samples and MM cell lines and functions as an oncogenic circRNA. It promotes MM cell proliferation, cell cycle progression and glycolysis while inhibiting apoptosis by sponging miR-331-3p to upregulate IGF1R."	0.7177
37174737	Cells	2023	"Functional Characterisation of the Circular RNA, circHTT(2-6), in Huntington's Disease."	hsa_circ_0001392	circHTT(2-6) / HSA_CIRCpedia_48392	hsa_circ_HTT	HTT	Huntington¡¯s disease / HD	MONDO:0007739	Huntington disease	up-regulated	RT-qPCR	circHTT(2-6) (hsa_circ_0001392) is up-regulated in the frontal cortex of Huntington¡¯s disease patients and correlates positively with CAG repeat length. Its overexpression in SH-SY5Y and HEK293 cells decreases proliferation and nuclear area and reduces nuclear localisation of HTT protein without changing total HTT protein levels or CAG repeat length.	0.7074
37182508	Translational oncology	2023	Differential expression and bioinformatics analysis of exosome circRNAs in pancreatic ductal adenocarcinoma.	hsa_circ_0006110		hsa_circ_USP34	USP34	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0006110 is up-regulated in PDAC and was validated by qRT-PCR in paired tissue samples, following initial microarray screening of serum exosomes and intersection with tissue data."	0.4773
37182508	Translational oncology	2023	Differential expression and bioinformatics analysis of exosome circRNAs in pancreatic ductal adenocarcinoma.	hsa_circ_0083172		hsa_circ_DNAJB6	DNAJB6	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; Microarray	hsa_circ_0083172 is up-regulated in PDAC and was validated by qRT-PCR after being identified among intersecting serum-exosome and tissue differentially expressed circRNAs.	0.4773
37182508	Translational oncology	2023	Differential expression and bioinformatics analysis of exosome circRNAs in pancreatic ductal adenocarcinoma.	hsa_circ_0000247		hsa_circ_MCU	MCU	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; Microarray	hsa_circ_0000247 is up-regulated in PDAC and was validated by qRT-PCR; the study did not experimentally establish a specific mechanism for this circRNA in PDAC.	0.4773
37182508	Translational oncology	2023	Differential expression and bioinformatics analysis of exosome circRNAs in pancreatic ductal adenocarcinoma.	hsa_circ_0076798		hsa_circ_GCLC	GCLC	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	down-regulated	RT-qPCR; Microarray	hsa_circ_0076798 is down-regulated in PDAC and its differential expression was validated by qRT-PCR in paired tissue samples.	0.4773
37182508	Translational oncology	2023	Differential expression and bioinformatics analysis of exosome circRNAs in pancreatic ductal adenocarcinoma.	hsa_circ_0018905		hsa_circ_SAMD8	SAMD8	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0018905 is down-regulated in PDAC (validated by qRT-PCR) and was used to construct a PDAC-specific predicted circRNA-miRNA-mRNA network involving seven candidate miRNAs and hundreds of target mRNAs; enrichment of targets implicated pathways such as PI3K-AKT, AGE-RAGE, and ECM-receptor interaction."	0.5135
37186007	Cancer science	2023	Circular RNA circARHGEF28 inhibited the progression of prostate cancer via the miR-671-5p/LGALS3BP/NF-kappaB axis.	hsa_circ_0005777	circARHGEF28	hsa_circ_ARHGEF28	ARHGEF28	prostate cancer / PCa	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR	"circARHGEF28 is down-regulated in prostate cancer and functions as a tumor suppressor by inhibiting proliferation, migration, and invasion in vitro and reducing xenograft growth in vivo. Mechanistically, it sponges miR-671-5p to restore LGALS3BP and thereby inhibits NF-kappaB pathway activation."	0.8635
37187897	Frontiers in molecular biosciences	2023	Identification of circRNA-miRNA-mRNA network in luminal breast cancers by integrated analysis of microarray datasets.	hsa_circ_0086735				breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"In luminal-subtype breast cancer, hsa_circ_0086735 is upregulated and functions as a ceRNA that sponges miR-1296-5p to increase STAT1 expression. This axis promotes proliferation, inhibits apoptosis, contributes to tamoxifen resistance, and high hsa_circ_0086735 predicts worse OS and DMFS."	0.8347
37192740	Thoracic cancer	2023	Circ_0069094 regulates malignant phenotype and paclitaxel resistance in breast cancer cells via targeting the miR-136-5p/YWHAZ axis.	hsa_circ_0069094	Circ_0069094	hsa_circ_S100P	S100 calcium binding protein P (S100P)	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"In PTX-resistant breast cancer, circ_0069094 is upregulated and promotes proliferation and invasion while inhibiting apoptosis and reducing paclitaxel sensitivity. Mechanistically, it sponges miR-136-5p to increase YWHAZ expression, forming a circ_0069094/miR-136-5p/YWHAZ axis that drives chemoresistance and malignant phenotypes."	0.7422
37192746	Thoracic cancer	2023	Exosomal ERBB2IP contributes to tumor growth via elevating PSAT1 expression in non-small cell lung carcinoma.	hsa_circ_0001492	circERBB2IP	hsa_circ_ERBB2IP	ERBB2IP	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"Exosomal circERBB2IP (hsa_circ_0001492, from ERBB2IP) is up-regulated in NSCLC serum exosomes and NSCLC cells and shows diagnostic potential (AUC reported). Functionally, circERBB2IP promotes NSCLC proliferation, migration, invasion, EMT, and xenograft tumor growth by sponging miR-5195-3p to increase PSAT1 expression."	0.7821
37194024	Cell division	2023	circRNA_0001006 predicts prognosis and regulates cellular processes of triple-negative breast cancer via miR-424-5p.	hsa_circ_0001006				triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"circ_0001006 is up-regulated in TNBC tissues and cell lines and is associated with more aggressive clinicopathological features and worse survival. Functionally, circ_0001006 promotes proliferation, migration and invasion of TNBC cells, at least partly by negatively regulating miR-424-5p (validated by luciferase assay and rescue experiments)."	0.7283
37197635	Translational lung cancer research	2023	Circ_0087378 intensifies the malignant behavior of non-small cell lung cancer cells in vitro by facilitating DDR1 via sponging miR-199a-5p.	hsa_circ_0087378	circ_0087378			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"In NSCLC cell lines, circ_0087378 is highly expressed and mainly localized in the cytoplasm. circ_0087378 promotes malignant phenotypes (proliferation, colony formation, migration and invasion) and inhibits apoptosis by sponging miR-199a-5p, thereby relieving miR-199a-5p-mediated repression of DDR1."	0.6585
37198696	Journal of experimental & clinical cancer research : CR	2023	CircZNF215 promotes tumor growth and metastasis through inactivation of the PTEN/AKT pathway in intrahepatic cholangiocarcinoma.		circZNF215 / cZNF215	hsa_circ_ZNF215	ZNF215	intrahepatic cholangiocarcinoma / ICC	MONDO:0003210	intrahepatic cholangiocarcinoma	up-regulated	RT-qPCR; RNA-seq	"cZNF215 is upregulated in iCCA and promotes tumor growth and metastasis. Mechanistically, it binds PRDX1 and competitively disrupts PRDX1-mediated protection of PTEN, increasing PTEN oxidation and activating AKT signaling; cZNF215 knockdown can enhance the antitumor effect of the AKT inhibitor ipatasertib."	0.8973
37217530	Scientific reports	2023	circDYRK1A tethers biological behaviors of gastric carcinoma using novel bioinformatics analysis and experimental validations.	hsa_circ_0001190	circDYRK1A	hsa_circ_DYRK1A	DYRK1A	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"circDYRK1A (hsa_circ_0001190) is down-regulated in gastric cancer tissues and GC cell lines. Overexpression of circDYRK1A inhibits proliferation, invasion, and migration of GC cells in vitro, and it is proposed to act via a circDYRK1A_miRNA_TP53 ceRNA axis."	0.6046
37217942	Journal of neuroinflammation	2023	Circular RNA Tmcc1 improves astrocytic glutamate metabolism and spatial memory via NF-kappaB and CREB signaling in a bile duct ligation mouse model: transcriptional and cellular analyses.		cirTmcc1 / circTmcc1	mmu_circ_Tmcc1	Tmcc1	hepatic encephalopathy / HE	MONDO:0001711	hepatic encephalopathy	down-regulated	RT-qPCR; RNA-seq	"In a BDL mouse model of hepatic encephalopathy and hyperammonemia-treated astrocytes, circTmcc1 is down-regulated in cortex and primarily cytoplasmic. It associates with a p65 NF-kappaB/CREB (and c-Jun) transcriptional complex to modulate EAAT2 promoter activity, thereby impacting astrocytic glutamate/glutamine balance, inflammatory mediator secretion, neuronal synaptic plasticity, and spatial memory."	0.7721
37218992	Non-coding RNA	2023	Inverse Impact of Cancer Drugs on Circular and Linear RNAs in Breast Cancer Cell Lines.		circVRK1	hsa_circ_VRK1	VRK1	breast cancer / BC	MONDO:0007254	breast cancer	dysregulated	RT-qPCR	"In breast cancer cell lines exposed to anticancer drugs, circVRK1 is generally increased while linVRK1 decreases. circVRK1 is described as limiting cell growth and promoting apoptosis, suggesting association with effective drug response."	0.2586
37218992	Non-coding RNA	2023	Inverse Impact of Cancer Drugs on Circular and Linear RNAs in Breast Cancer Cell Lines.		circMAN1A2	hsa_circ_MAN1A2	MAN1A2	breast cancer / BC	MONDO:0007254	breast cancer	dysregulated	RT-qPCR	"In breast cancer cell lines treated with anticancer drugs, circMAN1A2 is reported to be increased by several drugs and is associated with stimulating cell migration. This indicates a potentially dangerous drug-induced shift toward motility-related behavior."	0.1155
37218992	Non-coding RNA	2023	Inverse Impact of Cancer Drugs on Circular and Linear RNAs in Breast Cancer Cell Lines.		circGFRA1	hsa_circ_GFRA1	GFRA1	breast cancer / BC	MONDO:0007254	breast cancer	dysregulated	RT-qPCR	"circGFRA1 is a drug-responsive circRNA in breast cancer cell lines; in MDA-MB-231 it is decreased by AMG511 and GSK1070916, interpreted as an effective drug response. The paper cites that circGFRA1 binds miR-34a and is linked to proliferation/anti-apoptosis and poorer survival in triple-negative breast cancer, and proposes its downregulation as a biomarker of effective treatment."	0.1155
37218992	Non-coding RNA	2023	Inverse Impact of Cancer Drugs on Circular and Linear RNAs in Breast Cancer Cell Lines.		circHIPK3 	hsa_circ_HIPK3	HIPK3	breast cancer / BC	MONDO:0007254	breast cancer	dysregulated	RT-qPCR	"circHIPK3 is drug-responsive in breast cancer cell lines, often becoming upregulated after treatment. It is linked in the paper to EMT promotion, apoptosis suppression, and drug resistance, and is discussed as connected to PI3K/AKT-related context in MCF-7 cells."	0.1155
37218992	Non-coding RNA	2023	Inverse Impact of Cancer Drugs on Circular and Linear RNAs in Breast Cancer Cell Lines.		circ000911			breast cancer / BC	MONDO:0007254	breast cancer	dysregulated	RT-qPCR	circ000911 is among the circRNAs whose expression is modulated by anticancer drugs in breast cancer cell lines. The paper highlights an ERLOTINIB-specific association with circ000911 in MCF-7 cells.	0.1155
37218992	Non-coding RNA	2023	Inverse Impact of Cancer Drugs on Circular and Linear RNAs in Breast Cancer Cell Lines.		circESR1	hsa_circ_ESR1	ESR1	breast cancer / BC	MONDO:0007254	breast cancer	dysregulated	RT-qPCR	circESR1 is one of the circRNAs whose levels change upon anticancer drug treatment in MCF-7 cells; XL765 is reported to alter both ESR1 circular and linear isoforms.	0.1155
37218992	Non-coding RNA	2023	Inverse Impact of Cancer Drugs on Circular and Linear RNAs in Breast Cancer Cell Lines.		circIGF1R	hsa_circ_IGF1R	IGF1R	breast cancer / BC	MONDO:0007254	breast cancer	dysregulated	RT-qPCR	"circIGF1R is modulated by anticancer drugs in breast cancer cell lines. Unlike the general trend of circRNA increase with linRNA decrease, IGF1R shows a relative increase of both circular and linear forms in MCF-7, suggesting drug-specific regulation."	0.1155
37218992	Non-coding RNA	2023	Inverse Impact of Cancer Drugs on Circular and Linear RNAs in Breast Cancer Cell Lines.		circNCOA3	hsa_circ_NCOA3	NCOA3	breast cancer / BC	MONDO:0007254	breast cancer	dysregulated	RT-qPCR	circNCOA3 is a drug-modulated circRNA in breast cancer cell lines; the study notes that the host gene NCOA3 is an oncogene and that circNCOA3 is dysregulated by several agents (particularly in MCF-7). The function of the circular isoform is not established within this work.	0.1155
37218992	Non-coding RNA	2023	Inverse Impact of Cancer Drugs on Circular and Linear RNAs in Breast Cancer Cell Lines.		circAKT2	hsa_circ_AKT2	AKT2	breast cancer / BC	MONDO:0007254	breast cancer	dysregulated	RT-qPCR	"In MDA-MB-231 breast cancer cells treated with drugs, circAKT2 increases while the linear AKT2 isoform decreases. The study links this observation to the PI3K/AKT pathway context but notes that circAKT2¡¯s functional role remains unclear."	0.1155
37218992	Non-coding RNA	2023	Inverse Impact of Cancer Drugs on Circular and Linear RNAs in Breast Cancer Cell Lines.		circAKT3	hsa_circ_AKT3	AKT3	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circAKT3 is upregulated in drug-treated breast cancer cells (reported in the MDA-MB-231 context). The paper provides limited functional characterization for the circular isoform, noting only that the AKT3 gene encodes an anti-oncogenic protein."	0.1155
37220935	Thoracic cancer	2023	"Circular non-coding RNA circ_0072088 serves as a ceRNA, targeting the miR-1225-5p/WT1 axis to regulate non-small cell lung cancer cell malignant behavior."	hsa_circ_0072088	circ_0072088	hsa_circ_ZFR	ZFR	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0072088 is up-regulated in NSCLC tissues and cell lines and mainly localizes to the cytoplasm. It promotes malignant phenotypes (migration, invasion, glycolysis, and tumor growth) by acting as a ceRNA that sponges miR-1225-5p and upregulates WT1."	0.6815
37223528	Genes & diseases	2023	Circular RNA circEIF3C promotes intrahepatic cholangiocarcinoma progression and immune evasion via the miR-34a-5p/B7-H4 axis.	hsa_circ_0005602	circEIF3C	hsa_circ_EIF3C	eIF3c	intrahepatic cholangiocarcinoma / ICC	MONDO:0003210	intrahepatic cholangiocarcinoma	up-regulated	RT-qPCR	"circEIF3C (hsa_circ_0005602), derived from EIF3C, is up-regulated in intrahepatic cholangiocarcinoma and promotes tumor growth and invasiveness. Mechanistically, it sponges miR-34a-5p to increase B7-H4, leading to immune evasion (e.g., higher CD8+ T-cell apoptosis and reduced CD8+ infiltration) and is associated with poorer prognosis."	0.8102
37227531	Functional & integrative genomics	2023	Circular RNA circDLG1 contributes to HCC progression by regulating the miR-141-3p/WTAP axis.		circDLG1	hsa_circ_DLG1	DLG1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circDLG1 is up-regulated in HCC tissues and cell lines and is associated with shorter overall survival. Functionally, circDLG1 promotes HCC tumor growth and enhances glycolysis and sorafenib resistance. Mechanistically, circDLG1 mainly localizes to the cytoplasm and acts as a sponge for miR-141-3p to de-repress WTAP."	0.8244
37229188	Frontiers in genetics	2023	Identification and characterization of circular RNA in the model of autism spectrum disorder from PM2.5 exposure.		circ-Mbd5	rno_circ_Mbd5	Mbd5	autism spectrum disorder / ASD	MONDO:0005258	autism spectrum disorder	down-regulated	RT-qPCR; RNA-seq	"In PM2.5-exposed ASD-like rat hippocampus, circ-Mbd5 is down-regulated and was selected as a key candidate circRNA. The study predicts a circ-Mbd5-centered ceRNA network potentially linking miRNAs to ASD-associated risk genes, but direct functional experiments for the axis were not performed."	0.6956
37229188	Frontiers in genetics	2023	Identification and characterization of circular RNA in the model of autism spectrum disorder from PM2.5 exposure.		circ-Ash1l	rno_circ_Ash1l	Ash1l	autism spectrum disorder / ASD	MONDO:0005258	autism spectrum disorder	up-regulated	RT-qPCR; RNA-seq	"circ-Ash1l is up-regulated in the hippocampus of PM2.5-exposed ASD-like rats and is prioritized as a main candidate circRNA. The study constructs a predicted circ-Ash1l/miRNA/mRNA ceRNA network enriched with ASD-associated risk genes, but does not experimentally validate specific miRNA targets or downstream mRNAs."	0.5608
37231545	Thoracic cancer	2023	A novel molecular mechanism mediated by circCCDC134 regulates non-small cell lung cancer progression.	hsa_circ_0001238	circCCDC134	hsa_circ_CCDC134	CCDC134	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circCCDC134 is up-regulated in NSCLC tissues/cells and enriched in patient serum exosomes. Functionally, circCCDC134 promotes proliferation, migration/invasion, tumor growth, and glycolysis while inhibiting apoptosis by acting as a ceRNA that sponges miR-625-5p and derepresses NFAT5."	0.8327
37231931	Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)	2023	Circ_0081054 facilitates melanoma development via sponging miR-637 and regulating RAB9A.	hsa_circ_0081054	circ_0081054			melanoma	MONDO:0005105	melanoma	up-regulated	RT-qPCR	"circ_0081054 is up-regulated in melanoma tissues and cell lines and mainly localizes in the cytoplasm. It promotes melanoma malignant phenotypes (proliferation, invasion, glycolysis, and angiogenesis) and inhibits apoptosis, at least partly by sponging miR-637 to increase RAB9A expression; its knockdown suppresses xenograft tumor growth."	0.7982
37233428	Medicine	2023	Hsa_circ_0007401 regulates gemcitabine resistance of pancreatic cancer through the hsa-miR-6509-3p/fli1 axis.	hsa_circ_0007401		hsa_circ_NUP98	NUP98	pancreatic cancer	MONDO:0009831	malignant pancreatic neoplasm	down-regulated	RNA-seq	"This study identified hsa_circ_0007401 as down-regulated in gemcitabine-resistant pancreatic cancer cell-line datasets and proposed it participates in a ceRNA network. The inferred regulatory axis is hsa_circ_0007401_hsa-miR-6509-3p_FLI1, potentially related to gemcitabine resistance."	0.1768
37234568	Genetics research	2023	Bioinformatics-Based Identification of CircRNA-MicroRNA-mRNA Network for Calcific Aortic Valve Disease.	hsa_circ_0026817				Calcific aortic valve disease / CAVD	MONDO:0005463	aortic valve calcification	up-regulated	Microarray	"This study identified hsa_circ_0026817 as upregulated in CAVD by microarray-based differential expression and constructed a predicted ceRNA axis hsa_circ_0026817_hsa-miR-211-5p_CACNA1C. The proposed network suggests a potential role in VIC-related calcification and proliferative processes, but it is supported only by in-silico predictions and expression profiling."	0.1768
37234568	Genetics research	2023	Bioinformatics-Based Identification of CircRNA-MicroRNA-mRNA Network for Calcific Aortic Valve Disease.	hsa_circ_0007215				Calcific aortic valve disease / CAVD	MONDO:0005463	aortic valve calcification	down-regulated	Microarray	"This study identified hsa_circ_0007215 as downregulated in CAVD from a GEO circRNA microarray dataset and proposed two predicted ceRNA axes: hsa_circ_0007215_hsa-miR-1252-5p_MECP2 and hsa_circ_0007215_hsa-miR-1343-3p_RBL1. The proposed mechanisms link to MAPK-associated VIC calcification and TGF-beta/cell-cycle-related VEC proliferation regulation, based on bioinformatic network inference rather than experimental validation."	0.1768
37235279	Toxics	2023	Cigarette Smoke-Induced Gastric Cancer Cell Exosomes Affected the Fate of Surrounding Normal Cells via the Circ0000670/Wnt/beta-Catenin Axis.	hsa_circ_0000670	Circ0000670			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"Exosomal circ0000670 is up-regulated in gastric cancer patients with smoking history and in cigarette smoke-exposed gastric cancer cells/exosomes. It promotes proliferation, stemness, EMT and migration in recipient GES-1 cells, at least partly through activation of the Wnt/beta-catenin pathway (beta-catenin and c-Myc)."	0.7571
37237370	Journal of orthopaedic surgery and research	2023	Over-expression of hsa_circ_0088214 suppresses tumor progression by inhibiting Akt signaling pathway in osteosarcoma.	hsa_circ_0088214				osteosarcoma	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0088214 is down-regulated in osteosarcoma cell lines. Its overexpression suppresses invasion/migration and proliferation, reduces cisplatin resistance, and promotes H2O2-induced apoptosis, largely by inhibiting Akt signaling (reduced Akt phosphorylation), with SC79 rescuing these phenotypes."	0.5098
37238987	Biomedicines	2023	Aberrantly Expressed Hsa_circ_0060762 and CSE1L as Potential Peripheral Blood Biomarkers for ALS.	hsa_circ_0060762	hsa_circRNA_060762	hsa_circ_CSE1L	CSE1L	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR; Microarray	"hsa_circ_0060762 is significantly down-regulated in PBMCs from ALS patients versus controls and shows diagnostic potential (ROC AUC ~0.75). The study suggests it may have miRNA-binding capacity (miRNA-sponge-like role) based on circBank predictions, supporting its candidacy as a peripheral blood biomarker for ALS."	0.5963
37243831	Stem cell reviews and reports	2023	EIF4A3-Induced Exosomal circLRRC8A Alleviates Granulosa Cells Senescence Via the miR-125a-3p/NFE2L1 axis.	hsa_circ_0007311	circLRRC8A	hsa_circ_LRRC8A	LRRC8A	Premature ovarian failure / POF	MONDO:0001119	premature menopause	down-regulated	RT-qPCR; Microarray	"circLRRC8A is down-regulated in senescent granulosa cells and is enriched in BMSC-derived exosomes that alleviate oxidative damage and senescence in vitro and in a CTX-induced POF rat model. It mainly localizes in the cytoplasm and acts as a miR-125a-3p sponge to increase NFE2L1, while EIF4A3 promotes its biogenesis by binding LRRC8A pre-mRNA."	0.8428
37246269	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2023	"Smoking-Induced M2-TAMs, via circEML4 in EVs, Promote the Progression of NSCLC through ALKBH5-Regulated m6A Modification of SOCS2 in NSCLC Cells."	hsa_circ_0054243	circEML4	hsa_circ_EML4	EML4	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circEML4 is enriched in EVs from smoking/CSE-induced M2 macrophages and transferred to NSCLC cells. It binds ALKBH5, decreases nuclear ALKBH5, increases SOCS2 m6A modification leading to reduced SOCS2 and activation of JAK/STAT signaling, thereby promoting NSCLC cell proliferation, migration, invasion, tumor growth and metastasis; EV circEML4 is proposed as a diagnostic biomarker especially in smokers."	0.8624
37248471	Journal of translational medicine	2023	Circular RNA circ0001955 promotes cervical cancer tumorigenesis and metastasis via the miR-188-3p/NCAPG2 axis.	hsa_circ_0001955	circ0001955	hsa_circ_CSNK1G1	CSNK1G1	cervical squamous cell carcinoma / CSCC	MONDO:0006143	cervical squamous cell carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circ0001955 is upregulated in CSCC and promotes proliferation, migration/invasion, EMT, and xenograft tumor growth. It sponges miR-188-3p to upregulate NCAPG2 and activates the AKT/mTOR pathway; mTOR inhibition (rapamycin) counteracts circ0001955-driven effects."	0.8893
37250146	MedComm	2023	Isoliquiritigenin inhibits circ0030018 to suppress glioma tumorigenesis via the miR-1236/HER2 signaling pathway.	hsa_circ_0030018	Circ0030018 / circPOSTN	hsa_circ_POSTN	POSTN	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ0030018 (circPOSTN) is upregulated in glioma cell lines and promotes glioma proliferation, invasion and in vivo growth/metastasis. Mechanistically, it mainly functions as a ceRNA by sponging miR-1236 to increase HER2 expression; isoliquiritigenin reduces circ0030018 expression and suppresses glioma tumorigenesis via the circ0030018/miR-1236/HER2 axis."	0.6591
37250983	Biochemistry and biophysics reports	2023	The circRNA-0001361/miR-491/FGFR4 axis is associated with axillary response evaluated by ultrasound following NAC in subjects with breast cancer.	hsa_circ_0001361	circRNA_0001361 	hsa_circ_FNDC3B	FNDC3B	breast cancer / BC	MONDO:0007254	breast cancer	unknown	RT-qPCR	"In breast cancer patients receiving neoadjuvant chemotherapy, lower hsa_circ_0001361 expression is associated with better axillary response. Mechanistically, hsa_circ_0001361 acts as a sponge for miR-491-5p, leading to increased FGFR4 expression."	0.6765
37256443	Molecular and cellular biochemistry	2024	circSKA3 promotes colorectal cancer metastases through miR-1238 and methylation.		circSKA3			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circSKA3 is up-regulated in colorectal cancer tissues and promotes malignant phenotypes (proliferation, migration, invasion) in CRC cells. Mechanistically, circSKA3 acts as a ceRNA to sponge miR-1238, thereby increasing YTHDF2 expression and linking to reduced STAT5A methylation."	0.7032
37264022	Cell death & disease	2023	A novel protein encoded by circUBE4B promotes progression of esophageal squamous cell carcinoma by augmenting MAPK/ERK signaling.	hsa_circ_0005199	circUBE4B	hsa_circ_UBE4B	UBE4B	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circUBE4B (hsa_circ_0005199) is upregulated in ESCC and promotes ESCC cell proliferation and xenograft growth. Its tumor-promoting effect depends on translation of circUBE4B-173aa, which binds MAPK1, increases MAPK1 phosphorylation, and activates MAPK/ERK signaling; high circUBE4B is associated with worse patient survival."	0.7964
37264406	Journal of experimental & clinical cancer research : CR	2023	CREBZF mRNA nanoparticles suppress breast cancer progression through a positive feedback loop boosted by circPAPD4.	hsa_circ_0001504	circPAPD4	hsa_circ_PAPD4	PAPD4	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; ISH; Microarray	"circPAPD4 is down-regulated in breast cancer and functions as a tumor suppressor by inhibiting proliferation and promoting apoptosis. It mainly localizes to the cytoplasm and acts as a ceRNA by sponging miR-1269a to increase CREBZF, which inhibits STAT3 dimerization to reduce ADAR1 and thereby enhances circPAPD4 biogenesis in a positive feedback loop."	0.8941
37264961	Oncology reports	2023	GC_MSC_derived circ_0024107 promotes gastric cancer cell lymphatic metastasis via fatty acid oxidation metabolic reprogramming mediated by the miR_5572/6855_5p/CPT1A axis.	hsa_circ_0024107	circ_0024107	hsa_circ_MMP1	MMP1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"This study identifies circ_0024107 as an upregulated circRNA in gastric cancer tissues and GC-derived MSCs that promotes gastric cancer cell migration/invasion and lymphatic metastasis. circ_0024107 mainly localizes to the cytoplasm and functions as a miRNA sponge for miR-5572 and miR-6855-5p, thereby upregulating CPT1A to enhance fatty acid oxidation metabolic reprogramming. The circ_0024107/miR-5572/6855-5p/CPT1A axis is linked to lymph node metastasis and patient prognosis."	0.8746
37266374	Frontiers in molecular neuroscience	2023	Alzheimer's disease pathogenetic progression is associated with changes in regulated retained introns and editing of circular RNAs.		circMAN2A1	hsa_circ_MAN2A1	MAN2A1	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RNA-seq	"circMAN2A1 is increased with AD progression (Braak NFT stages) in human entorhinal cortex. The study shows that A-to-I RNA editing (via ADAR1/ADAR2) enables circMAN2A1 translation, producing novel circRNA-derived proteins due to out-of-frame start codons relative to the linear MAN2A1 mRNA."	0.6131
37269429	Discover oncology	2023	CircHIPK3 negatively regulates autophagy by blocking VCP binding to the Beclin 1 complex in bladder cancer.	hsa_circ_0000284	circHIPK3 / Circular RNA HIPK3	hsa_circ_HIPK3	HIPK3	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR	"circHIPK3 (hsa_circ_0000284) is down-regulated in bladder cancer tissues and cell lines and acts as a tumor suppressor. It inhibits proliferation and autophagy by directly binding VCP and weakening the VCP_Beclin 1 interaction, reducing Beclin 1-associated autophagy activity."	0.7788
37272875	The Kaohsiung journal of medical sciences	2023	Circ-MALAT1 accelerates cell proliferation and epithelial mesenchymal transformation of colorectal cancer through regulating miR-506-3p/KAT6B axis.		circ_MALAT1	hsa_circ_MALAT1		colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_MALAT1 is up-regulated in CRC tissues and CRC cell lines. It promotes CRC cell proliferation, migration and EMT by sponging miR-506-3p to increase KAT6B expression, with functional rescue by miR-506-3p inhibition or KAT6B overexpression."	0.6521
37273760	Experimental and therapeutic medicine	2023	Circular RNA DHTKD1 targets miR_338_3p/ETS1 axis to regulate the inflammatory response in human bronchial epithelial cells.	hsa_circ_0017724	circDHTKD1	hsa_circ_DHTKD1	DHTKD1	asthma	MONDO:0004979	asthma	up-regulated	RT-qPCR; RNA-seq	"In an LPS-induced in vitro airway epithelial inflammation model relevant to asthma, circDHTKD1 is up-regulated and mainly localized in the cytoplasm. circDHTKD1 promotes inflammatory cytokine production by sponging miR-338-3p, thereby relieving repression of ETS1 and enhancing ERK pathway activation."	0.7296
37275445	World journal of gastrointestinal oncology	2023	Circ_0003356 suppresses gastric cancer growth through targeting the miR-668-3p/SOCS3 axis.	hsa_circ_0003356	Circ_0003356			gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"circ_0003356 is down-regulated in gastric cancer tissues and cells and functions as a tumor suppressor. It mainly localizes to the cytoplasm and inhibits GC proliferation, migration, invasion, EMT while promoting apoptosis by sponging miR-668-3p to upregulate SOCS3. Higher circ_0003356 expression is associated with better patient survival."	0.823
37277864	Thoracic cancer	2023	Circ_0010235 confers cisplatin resistance in lung cancer by upregulating E2F7 through absorbing miR-379-5p.	hsa_circ_0010235	circ_0010235	hsa_circ_ALDH4A1	ALDH4A1	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circ_0010235 is up-regulated in cisplatin (DDP)-resistant lung cancer tissues/cells and promotes chemoresistance and malignant phenotypes. It primarily acts in the cytoplasm as a ceRNA, sponging miR-379-5p to de-repress E2F7, thereby enhancing DDP resistance and tumor growth."	0.786
37280630	World journal of surgical oncology	2023	Circular RNA hsa_circ_0064559 affects tumor cell growth and progression of colorectal cancer.	hsa_circ_0064559				colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0064559 is up-regulated in colorectal cancer. Its knockdown suppresses CRC cell proliferation, increases apoptosis and G1-phase accumulation in vitro, and inhibits tumor growth in a nude-mouse xenograft model, accompanied by broad changes in apoptosis/proliferation-related gene expression (e.g., STAT1, BAX, CD274)."	0.5802
37280654	Biomarker research	2023	EIF4A3-induced Circ_0001187 facilitates AML suppression through promoting ubiquitin-proteasomal degradation of METTL3 and decreasing m6A modification level mediated by miR-499a-5p/RNF113A pathway.	hsa_circ_0001187	Circ_0001187 / Circ _0001187	hsa_circ_DOPEY2	DOPEY2	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	down-regulated	RT-qPCR; Microarray	"Circ_0001187 is down-regulated in AML and functions as a tumor suppressor. It mainly localizes to the cytoplasm and acts as a ceRNA to sponge miR-499a-5p, thereby upregulating RNF113A to promote ubiquitin-proteasomal degradation of METTL3, reducing m6A modification and inhibiting AML proliferation while promoting apoptosis. Low Circ_0001187 is associated with worse clinical outcomes and shows diagnostic potential."	0.9043
37286730	Scientific reports	2023	Comprehensive analysis of the coding and non-coding RNA transcriptome expression profiles of hippocampus tissue in tx-J animal model of Wilson's disease.	mmu_circ_0001700				Wilson's disease / WD	MONDO:0010200	Wilson disease	up-regulated	RT-qPCR; RNA-seq	"mmu_circ_0001700 is significantly up-regulated in hippocampal tissue of tx-J Wilson's disease model mice versus controls, confirmed by qRT-PCR after RNA-seq discovery."	0.4062
37286730	Scientific reports	2023	Comprehensive analysis of the coding and non-coding RNA transcriptome expression profiles of hippocampus tissue in tx-J animal model of Wilson's disease.	mmu_circ_0001662				Wilson's disease / WD	MONDO:0010200	Wilson disease	up-regulated	RT-qPCR; RNA-seq	"mmu_circ_0001662 is significantly up-regulated in hippocampal tissue of tx-J Wilson's disease model mice versus controls, confirmed by qRT-PCR after RNA-seq discovery."	0.3213
37286730	Scientific reports	2023	Comprehensive analysis of the coding and non-coding RNA transcriptome expression profiles of hippocampus tissue in tx-J animal model of Wilson's disease.	mmu_circ_0001859				Wilson's disease / WD	MONDO:0010200	Wilson disease	down-regulated	RT-qPCR; RNA-seq	"mmu_circ_0001859 is significantly down-regulated in hippocampal tissue of tx-J Wilson's disease model mice versus controls, confirmed by qRT-PCR after RNA-seq discovery. It is reported to be associated (by enrichment/association analysis) with multiple pathways including axon guidance and several signaling pathways."	0.3213
37286730	Scientific reports	2023	Comprehensive analysis of the coding and non-coding RNA transcriptome expression profiles of hippocampus tissue in tx-J animal model of Wilson's disease.	mmu_circ_0000626				Wilson's disease / WD	MONDO:0010200	Wilson disease	down-regulated	RT-qPCR; RNA-seq	"mmu_circ_0000626 is significantly down-regulated in hippocampal tissue of tx-J Wilson's disease model mice versus controls, confirmed by qRT-PCR after RNA-seq discovery."	0.3213
37286730	Scientific reports	2023	Comprehensive analysis of the coding and non-coding RNA transcriptome expression profiles of hippocampus tissue in tx-J animal model of Wilson's disease.	mmu_circ_0000460				Wilson's disease / WD	MONDO:0010200	Wilson disease	down-regulated	RT-qPCR; RNA-seq	"mmu_circ_0000460 is significantly down-regulated in hippocampal tissue of tx-J Wilson's disease model mice versus controls, confirmed by qRT-PCR after RNA-seq discovery."	0.3213
37298501	International journal of molecular sciences	2023	MITA Promotes Macrophage Proinflammatory Polarization and Its circRNA-Related Regulatory Mechanism in Recurrent Miscarriage.	hsa_circ_0003241	circKIAA0391	hsa_circ_KIAA0391	KIAA0391	recurrent miscarriage / RM	MONDO:0013727	"pregnancy loss, recurrent, susceptibility to, 1"	up-regulated	RT-qPCR; RNA-seq	"In recurrent miscarriage, circKIAA0391 is up-regulated in decidual macrophages and predominantly localizes in the cytoplasm. It promotes THP-1-derived macrophage apoptosis and M1 proinflammatory polarization by acting as a miRNA sponge for miR-512-5p, thereby relieving repression of MITA (STING) in a circKIAA0391/miR-512-5p/MITA ceRNA axis."	0.7832
37303741	Oncology research	2023	Has_circ_0000069 expression in breast cancer and its influences on prognosis and cellular activities.	hsa_circ_0000069	circ_0000069			breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"has_circ_0000069 is up-regulated in breast cancer tissues/cell lines and promotes proliferation, migration and invasion. Mechanistically, it functions as a ceRNA by sponging miR-432, and high expression predicts poorer overall survival."	0.6987
37304410	Oncology research	2022	CircMAN1A2 promotes vasculogenic mimicry of nasopharyngeal carcinoma cells through upregulating ERBB2 via sponging miR-940.	hsa_circ_0000119	circMAN1A2	hsa_circ_MAN1A2	MAN1A2	nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; ISH	"circMAN1A2 is highly expressed in NPC and promotes proliferation, migration, and vasculogenic mimicry. It functions as a ceRNA by sponging miR-940, thereby relieving miR-940-mediated repression of ERBB2 and activating PI3K/AKT/mTOR signaling."	0.5679
37304473	Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion	2023	The Circular RNA Circ-ANAPC7 as a Biomarker for the Risk Stratification of Myelodysplastic Syndrome.		circ-ANAPC7 / hsa-circRNA-101141	hsa_circ_ANAPC7	ANAPC7	Myelodysplastic syndrome / MDS	MONDO:0018881	myelodysplastic syndrome	up-regulated	RT-qPCR	"In bone marrow samples from MDS patients, circ-ANAPC7 expression is higher than controls and increases stepwise across IPSS-R risk groups. circ-ANAPC7 provides strong ROC-based discrimination between adjacent risk strata, supporting its use as a diagnostic/risk-stratification biomarker."	0.4187
37304971	International journal of nanomedicine	2023	Extracellular Vesicles Derived circSH3PXD2A Inhibits Chemoresistance of Small Cell Lung Cancer by miR-375-3p/YAP1.	hsa_circ_0019869	circSH3PXD2A / cricSH3PXD2A 	hsa_circ_SH3PXD2A	SH3PXD2A	small cell lung cancer / SCLC	MONDO:0008433	small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	"circSH3PXD2A is down-regulated in chemoresistant SCLC and in EVs from DDP-resistant patients. It is delivered via extracellular vesicles and suppresses SCLC chemoresistance and malignant phenotypes by sponging miR-375-3p to upregulate YAP1, showing potential as a predictor for DDP resistance (especially in EVs, combined with ProGRP)."	0.879
37305177	Non-coding RNA research	2023	Circular SERPINA3 and its target microRNA-944 as potential biomarkers in hepatitis C virus-induced hepatocellular carcinoma in Egyptian population.		circSERPINA3 / circSERPINA-3	hsa_circ_SERPINA3	SERPINA3	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"In Egyptian patients with HCV infection and HCV-induced HCC, circSERPINA3 is upregulated in plasma/PMNC-derived RNA and is inversely correlated with miR-944. The study supports a ceRNA-like mechanism where circSERPINA3 sponges miR-944, associated with increased MDM2 and enhanced malignant phenotypes (proliferation/metastasis) and poorer short-term survival, and it shows diagnostic value by ROC analysis."	0.5339
37305524	"Open medicine (Warsaw, Poland)"	2023	Circular RNA Circ_0038467 promotes the maturation of miRNA-203 to increase lipopolysaccharide-induced apoptosis of chondrocytes.	hsa_circ_0038467	Circ_0038467	hsa_circ_UQCRC2	UQCRC2	osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"Circ_0038467 is up-regulated in osteoarthritis synovial fluid and can be induced by LPS in chondrocytes. It promotes maturation of miR-203 via direct interaction with the miR-203 precursor and increases LPS-induced chondrocyte apoptosis in a miR-203-dependent manner, suggesting potential value as a treatment-response indicator and therapeutic target."	0.6166
37312060	BMC genomics	2023	Identification of novel prognostic circRNA biomarkers in circRNA-miRNA-mRNA regulatory network in gastric cancer and immune infiltration analysis.	hsa_circ_0063853				gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	Microarray	"hsa_circ_0063853 is identified as an upregulated circRNA in gastric cancer and is used to build an upregulated circRNA-miRNA-mRNA (ceRNA) regulatory network. Functional enrichment of its network suggests involvement in extracellular matrix/structure-related functions, implying a potential role in GC progression."	0.1768
37312060	BMC genomics	2023	Identification of novel prognostic circRNA biomarkers in circRNA-miRNA-mRNA regulatory network in gastric cancer and immune infiltration analysis.	hsa_circ_0000673				gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	Microarray	"hsa_circ_0000673 is identified as a downregulated circRNA in gastric cancer and incorporated into the downregulated circRNA-miRNA-mRNA network. Enrichment results for the downregulated circRNA network link it to physiological functions such as protein processing, energy metabolism, and gastric acid secretion."	0.1768
37312060	BMC genomics	2023	Identification of novel prognostic circRNA biomarkers in circRNA-miRNA-mRNA regulatory network in gastric cancer and immune infiltration analysis.	hsa_circ_0005777				gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	Microarray	"hsa_circ_0005777 is identified as a downregulated circRNA in gastric cancer and incorporated into the downregulated circRNA-miRNA-mRNA network. Enrichment results for the downregulated circRNA network link it to physiological functions such as protein processing, energy metabolism, and gastric acid secretion."	0.1768
37312060	BMC genomics	2023	Identification of novel prognostic circRNA biomarkers in circRNA-miRNA-mRNA regulatory network in gastric cancer and immune infiltration analysis.	hsa_circ_0008801				gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	Microarray	"hsa_circ_0008801 is identified as a downregulated circRNA in gastric cancer and incorporated into the downregulated circRNA-miRNA-mRNA network. Enrichment results for the downregulated circRNA network link it to physiological functions such as protein processing, energy metabolism, and gastric acid secretion."	0.1768
37312219	Journal of orthopaedic surgery and research	2023	Knockdown of circSOD2 ameliorates osteoarthritis progression via the miR-224-5p/PRDX3 axis.	hsa_circ_0004662	circSOD2 / circ_0004662	hsa_circ_SOD2	SOD2	osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; Microarray	"circSOD2 (hsa_circ_0004662) is up-regulated in OA knee cartilage and IL-1beta-treated CHON-001 chondrocytes. Silencing circSOD2 protects chondrocytes by reducing apoptosis, inflammation, and ECM degradation, via a ceRNA mechanism involving miR-224-5p and PRDX3."	0.7618
37316908	BMC medical genomics	2023	Interaction between the expression of hsa_circRPRD1A and hsa_circHERPUD2 and classical coronary risk factors promotes the development of coronary artery disease.		hsa_circRPRD1A	hsa_circ_RPRD1A	RPRD1A	coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	down-regulated	RT-qPCR; RNA-seq	"hsa_circRPRD1A is significantly down-regulated in PBMCs of CAD patients and shows diagnostic potential (ROC AUC 0.689). Higher hsa_circRPRD1A expression is associated with reduced CAD prevalence (protective factor), and it is included in a predicted circRNA-miRNA-mRNA ceRNA network relevant to CAD."	0.6895
37316908	BMC medical genomics	2023	Interaction between the expression of hsa_circRPRD1A and hsa_circHERPUD2 and classical coronary risk factors promotes the development of coronary artery disease.		hsa_circHERPUD2	hsa_circ_HERPUD2	HERPUD2	coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	down-regulated	RT-qPCR; RNA-seq	"hsa_circHERPUD2 is significantly down-regulated in PBMCs of CAD patients and has moderate diagnostic value (ROC AUC 0.662). Its expression shows a significant antagonistic interaction with alcohol consumption in CAD subjects, and it is part of a predicted circRNA-miRNA-mRNA ceRNA network linked to CAD."	0.6895
37318258	"Cell cycle (Georgetown, Tex.)"	2023	Hsa_circ_0014784-induced YAP1 promoted the progression of pancreatic cancer by sponging miR-214-3p.	hsa_circ_0014784		hsa_circ_HDGF	HDGF	pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; ISH; RNA-seq	"hsa_circ_0014784 (circ-HDGF) is up-regulated in pancreatic cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes pancreatic cancer proliferation, migration/invasion, EMT, angiogenesis, tumor growth and metastasis by sponging miR_214-3p to increase YAP1 expression (hsa_circ_0014784/miR_214-3p/YAP1 axis)."	0.7035
37322492	Journal of ovarian research	2023	Exosomal circ_0008285 in follicle fluid regulates the lipid metabolism through the miR-4644/ LDLR axis in polycystic ovary syndrome.	hsa_circ_0008285	circ_0008285 / circ_CDYL	hsa_circ_CDYL	CDYL	polycystic ovary syndrome / PCOS	MONDO:0008487	polycystic ovary syndrome	down-regulated	RT-qPCR; RNA-seq	"In PCOS follicular-fluid exosomes, circ_0008285 is decreased and functions as a ceRNA in granulosa cells. It sponges miR-4644 to relieve repression of LDLR, thereby modulating cholesterol/lipid metabolism and lipid secretion (e.g., free fatty acids)."	0.8111
37322492	Journal of ovarian research	2023	Exosomal circ_0008285 in follicle fluid regulates the lipid metabolism through the miR-4644/ LDLR axis in polycystic ovary syndrome.	hsa_circ_0044234	Circ_0044234			polycystic ovary syndrome / PCOS	MONDO:0008487	polycystic ovary syndrome	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0044234 is up-regulated in PCOS follicular-fluid exosomes and was among the four circRNAs validated by RT-qPCR, but no downstream mechanism or functional assays were reported for it in this paper."	0.4679
37322492	Journal of ovarian research	2023	Exosomal circ_0008285 in follicle fluid regulates the lipid metabolism through the miR-4644/ LDLR axis in polycystic ovary syndrome.	hsa_circ_0013167	circ_0013167			polycystic ovary syndrome / PCOS	MONDO:0008487	polycystic ovary syndrome	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0013167 is down-regulated in PCOS follicular-fluid exosomes and was validated by RT-qPCR, but the study did not further characterize its mechanism or function."	0.4679
37322492	Journal of ovarian research	2023	Exosomal circ_0008285 in follicle fluid regulates the lipid metabolism through the miR-4644/ LDLR axis in polycystic ovary syndrome.	hsa_circ_0006877	circ_0006877			polycystic ovary syndrome / PCOS	MONDO:0008487	polycystic ovary syndrome	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0006877 is down-regulated in PCOS follicular-fluid exosomes and was validated by RT-qPCR, but the paper did not provide functional/mechanistic characterization for this circRNA."	0.4679
37323876	MedComm	2023	Diagnosis of acute myocardial infarction using a combination of circulating circular RNA cZNF292 and clinical information based on machine learning.		cZNF292	hsa_circ_ZNF292	ZNF292	acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR	"Circulating cZNF292 is up-regulated in whole blood of AMI (and ACS) patients and, when combined with basic clinical information, improves diagnostic performance in machine-learning/logistic-regression models. Functionally, cZNF292 is induced by OGD/R in endothelial cells and hESC-derived cardiomyocytes, and its knockdown reduces apoptosis, suggesting a pro-apoptotic role under ischemia/reperfusion-like stress."	0.7468
37324105	Journal of thoracic disease	2023	Extracellular RNA profiles in non-small cell lung cancer plasma.	hsa_circ_0000722				non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0000722 is up-regulated in NSCLC patient plasma and was proposed as a circulating biomarker. Bioinformatic predictions suggest it may act as a miRNA sponge for miR-324-5p/miR-326/miR-330-5p and relate to cancer-associated pathways.	0.4032
37324880	Food science & nutrition	2023	Anthocyanins improve liver fibrosis in mice by regulating the autophagic flux level of hepatic stellate cells by mmu_circ_0000623.	mmu_circ_0000623	circ_0000623	mmu_circ_Tnrc6b	Tnrc6b	liver fibrosis	MONDO:0005155	cirrhosis of liver	down-regulated	RT-qPCR	"mmu_circ_0000623 (circ_0000623) is down-regulated in CCl4-induced mouse liver fibrosis and in PDGF-activated mHSCs, while anthocyanins restore its expression. circ_0000623 inhibits HSC proliferation/activation/migration and alleviates fibrosis by sponging miR-351-5p to upregulate TFEB, improving lysosomal function and autophagic flux."	0.7635
37324942	International journal of biological sciences	2023	EIF4a3-regulated circRABL2B regulates cell stemness and drug sensitivity of lung cancer via YBX1-dependent downregulation of MUC5AC expression.	hsa_circ_0064019	circRABL2B	hsa_circ_RABL2B	RABL2B	lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR; Microarray	"circRABL2B is down-regulated in lung cancer and functions as a tumor suppressor. It binds the RBP YBX1 to reduce MUC5AC expression (reported to involve MUC5AC mRNA degradation), thereby dampening integrin beta4/pSrc signaling, enhancing p53 signaling, reducing cancer stemness, and increasing erlotinib sensitivity; exosome-delivered circRABL2B shows therapeutic and diagnostic potential."	0.8847
37324942	International journal of biological sciences	2023	EIF4a3-regulated circRABL2B regulates cell stemness and drug sensitivity of lung cancer via YBX1-dependent downregulation of MUC5AC expression.	hsa_circ_0001166	circSULF2	hsa_circ_SULF2	SULF2	lung cancer	MONDO:0008903	lung cancer	up-regulated	Microarray	"circSULF2 (hsa_circ_0001166) is reported as up-regulated in lung cancer and positively correlated with MUC5B, but it showed no association with survival and its knockdown did not significantly affect malignant phenotypes, so it was not further investigated."	0.1768
37326330	Cancer biology & therapy	2023	Exosome-transmitted hsa_circ_0012634 suppresses pancreatic ductal adenocarcinoma progression through regulating miR-147b/HIPK2 axis.	hsa_circ_0012634		hsa_circ_TMEM59	TMEM59	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0012634 is down-regulated in PDAC tissues/cells and in serum exosomes from PDAC patients. Functionally, its overexpression (including exosome-delivered form) inhibits PDAC proliferation and glycolysis and promotes apoptosis by sponging miR-147b to derepress HIPK2, reducing tumor growth in a PANC-1 xenograft model and showing diagnostic potential by ROC analysis."	0.8657
37328278	Stroke and vascular neurology	2024	Penumbra-targeted CircOGDH siRNA-loaded nanoparticles alleviate neuronal apoptosis in focal brain ischaemia.		circular oxoglutarate dehydrogenase / CircOGDH	mmu_circ_OGDH	OGDH	ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR	"CircOGDH (derived from OGDH) is upregulated in acute ischaemic stroke contexts (prior work) and functions pro-apoptotically in neurons. In this study, PLGA_PAMAM nanoparticles delivering CircOGDH siRNA reduced CircOGDH expression in penumbra tissue, lowered neuronal apoptosis markers, reduced infarct size, and improved neurological function in MCAO/R mice and OGD/R neurons, consistent with a CircOGDH_miR-5112_COL4A4 regulatory axis."	0.4249
37328740	BMC pulmonary medicine	2023	Identification and bioinformatic analysis of CircRNAs in the plasma of patients with very severe chronic obstructive pulmonary disease.	hsa_circ_0062683	hsa_circRNA_062683			chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR; Microarray	hsa_circ_0062683 is up-regulated in plasma from patients with very severe COPD and validated by RT-qPCR. It shows diagnostic potential by ROC analysis and correlates with clinical indicators (positively with age and negatively with FEV1%pred).	0.5047
37328740	BMC pulmonary medicine	2023	Identification and bioinformatic analysis of CircRNAs in the plasma of patients with very severe chronic obstructive pulmonary disease.	hsa_circ_0089763	hsa_circRNA_089763			chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	down-regulated	RT-qPCR; Microarray	hsa_circ_0089763 is down-regulated in plasma from patients with very severe COPD and validated by RT-qPCR. It has diagnostic value by ROC analysis and shows correlations with clinical indices (negative with WBCs and positive with FEV1%pred).	0.5047
37328740	BMC pulmonary medicine	2023	Identification and bioinformatic analysis of CircRNAs in the plasma of patients with very severe chronic obstructive pulmonary disease.	hsa_circ_0008882	hsa_circRNA_008882			chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	down-regulated	RT-qPCR; Microarray	hsa_circ_0008882 is down-regulated in plasma from patients with very severe COPD and validated by RT-qPCR. It shows strong diagnostic potential by ROC analysis and correlates with inflammatory and lung-function indicators (WBCs/CRP negatively; FEV1%pred positively).	0.5047
37333495	Pharmacogenomics and personalized medicine	2023	Exploration into Plasma Hsa_circ_0052184 as a New Biomarker of Colorectal Cancer Prognosis.	hsa_circ_0052184		hsa_circ_PPP1R12C	PPP1R12C	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0052184 is up-regulated in CRC tissues, CRC cell lines, and patient plasma. Functional knockdown in CRC cells suppresses proliferation, migration, and invasion, and clinically higher plasma levels are linked to worse survival and show high diagnostic performance."	0.7085
37334578	Cancer biomarkers : section A of Disease markers	2024	circ_0058063 promotes breast cancer progression by upregulating DLGAP5 via sponging miR-557.	hsa_circ_0058063	circ_0058063			breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0058063 is up-regulated in breast cancer tissues/cells and promotes proliferation, migration and tumor growth while inhibiting apoptosis. It functions mainly in the cytoplasm as a miRNA sponge for miR-557, thereby relieving miR-557-mediated repression and upregulating DLGAP5."	0.6959
37337843	Thoracic cancer	2023	Circ_0008285 silencing suppresses angiotensin II-induced vascular smooth muscle cell apoptosis in thoracic aortic aneurysm via miR-150-5p/BASP1 axis.	hsa_circ_0008285	circ_0008285	hsa_circ_CDYL	CDYL	thoracic aortic aneurysm / TAA	MONDO:0005396	thoracic aortic aneurysm	up-regulated	RT-qPCR	"circ_0008285 is up-regulated in TAA aortic tissue and in Ang II_treated human VSMCs, where it promotes apoptosis and proliferation arrest. Mechanistically, it sponges miR-150-5p to increase BASP1, and it can be packaged into exosomes for intercellular transfer."	0.7581
37340423	Journal of translational medicine	2023	CircNFATC3 promotes the proliferation of gastric cancer through binding to IGF2BP3 and restricting its ubiquitination to enhance CCND1 mRNA stability.	hsa_circ_0000711	circNFATC3 / circular nuclear factor of activated T cells 3 	hsa_circ_NFATC3	NFATC3	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; ISH	"CircNFATC3 is upregulated in gastric cancer and promotes tumor cell proliferation. It binds IGF2BP3 in the cytoplasm, inhibits TRIM25-mediated ubiquitination to stabilize IGF2BP3, and thereby enhances CCND1 mRNA stability."	0.8467
37344798	Respiratory research	2023	CircItgb5 promotes synthetic phenotype of pulmonary artery smooth muscle cells via interacting with miR-96-5p and Uba1 in monocrotaline-induced pulmonary arterial hypertension.		circItgb5	rno_circ_Itgb5	Itgb5	pulmonary arterial hypertension / PAH	MONDO:0015924	pulmonary arterial hypertension	up-regulated	RT-qPCR; RNA-seq	"CircItgb5 is up-regulated in PDGF-BB-stimulated PASMCs and in MCT-induced PAH rats, where it promotes the PASMC synthetic phenotype and proliferation and contributes to pulmonary vascular remodeling. It functions by sponging miR-96-5p to increase mTOR and by binding Uba1 to modulate the Ube2n/Mdm2/ACE2 cascade."	0.8478
37349870	Thoracic cancer	2023	Circ-PDZD8 promotes cell growth and glutamine metabolism in non-small cell lung cancer by enriching LARP1 via sequestering miR-330-5p.		circ-PDZD8 / circRNA_PDZ domain containing 8	hsa_circ_PDZD8	PDZD8	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"Circ-PDZD8 is up-regulated in NSCLC tissues and cell lines and mainly localizes to the cytoplasm. It promotes malignant phenotypes and glutamine metabolism by sponging miR-330-5p to increase LARP1 expression, thereby enhancing tumor growth in vitro and in a xenograft model."	0.7637
37349877	Thoracic cancer	2023	Silencing of circUSPL1 represses breast cancer progression by targeting miR-1296-5p/MTA1 axis.	hsa_circ_0100213	circUSPL1	hsa_circ_USPL1	USPL1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circUSPL1 is up-regulated in breast cancer tissues and cell lines and mainly localizes to the cytoplasm. Functionally, circUSPL1 promotes malignant phenotypes (proliferation, migration, invasion, glycolysis) and inhibits apoptosis by acting as a ceRNA that sponges miR-1296-5p to increase MTA1, thereby supporting tumor growth in vivo."	0.8465
37350305	Annals of clinical and translational neurology	2023	Increased plasma levels of circPTP4A2 and circTLK2 are associated with stroke injury.	hsa_circ_0007364	circPTP4A2	hsa_circ_PTP4A2	PTP4A2	ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR	"Plasma circPTP4A2 is up-regulated in AIS patients and higher levels are associated with greater stroke severity (NIHSS) and certain TOAST subtypes (notably LAA). Baseline levels are not predictive of outcome, but the 7-day change in circPTP4A2 helps predict unfavorable 90-day functional outcome."	0.5121
37350305	Annals of clinical and translational neurology	2023	Increased plasma levels of circPTP4A2 and circTLK2 are associated with stroke injury.	hsa_circ_0045128	circTLK2	hsa_circ_TLK2	TLK2	ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR	"Plasma circTLK2 is up-regulated in AIS patients and higher levels are associated with greater stroke severity (NIHSS) and TOAST subtypes (more evident increase in LAA). Baseline levels are not predictive of outcome, but the 7-day change in circTLK2 helps predict unfavorable 90-day functional outcome."	0.5121
37357644	Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)	2023	Hsa_circ_0005085 may suppress cutaneous squamous cell carcinoma growth and metastasis through targeting the miR-186-5p/LAMC1 axis.	hsa_circ_0005085	hsa_circRNA_102612 / circ_0005085	hsa_circ_ASAP2	ASAP2	cutaneous squamous cell carcinoma / CSCC	MONDO:0002529	skin squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0005085 is down-regulated in CSCC and functions as a tumor suppressor. It sponges miR-186-5p to relieve repression of LAMC1, thereby inhibiting proliferation, migration/invasion and EMT while promoting apoptosis, and it suppresses xenograft tumor growth via the miR-186-5p/LAMC1 axis."	0.8175
37359246	Molecular & cellular toxicology	2023	CircSLCO3A1 depletion ameliorates lipopolysaccharide-induced inflammation and apoptosis of human pulmonary alveolar epithelial cells through the miR-424-5p/HMGB3 pathway.	hsa_circ_0003252	circSLCO3A1 / circ_0003252	hsa_circ_SLCO3A1	SLCO3A1	acute lung injury / ALI	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR	"In LPS-induced ALI-like injury models (HPAEpiCs) and in serum from septic ALI patients, circSLCO3A1 is upregulated. circSLCO3A1 promotes inflammatory responses and apoptosis by sponging miR-424-5p, which relieves repression of HMGB3; circSLCO3A1 knockdown mitigates these injuries."	0.8138
37360090	Heliyon	2023	Circular RNA circBNC2 facilitates glycolysis and stemness of hepatocellular carcinoma through the miR-217/high mobility group AT-hook 2 (HMGA2) axis.	hsa_circ_0008732	circBNC2 / circ-BNC2	hsa_circ_BNC2	BNC2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circBNC2 is up-regulated in HCC tissues/cells and is associated with worse survival and more aggressive clinicopathological features. Functionally, circBNC2 promotes HCC proliferation, glycolysis and stemness and supports tumor growth in xenografts. Mechanistically, it acts as a ceRNA sponge for miR-217 to de-repress HMGA2, influencing downstream growth/glycolysis/stemness markers such as PCNA, HK2 and OCT4."	0.8354
37360167	Frontiers in neuroscience	2023	Prenatal alcohol exposure dysregulates spinal and circulating immune cell circular RNA expression in adult female rats with chronic sciatic neuropathy.		circVopp1	rno_circ_Vopp1	Vopp1	Fetal Alcohol Spectrum Disorders / FASD	MONDO:0000408	fetal alcohol spectrum disorder	dysregulated	RT-qPCR; Microarray	"circVopp1 is persistently dysregulated by prenatal alcohol exposure in adult rats, showing decreased expression in blood leukocytes and increased expression in spinal cord. Its dysregulation occurs alongside altered Vopp1 mRNA (in leukocytes) and is proposed to contribute to aberrant NF-kappaB-related immune signaling, with potential utility as a biomarker of PAE/FASD-related CNS dysfunction and neuropathic pain susceptibility."	0.5608
37360167	Frontiers in neuroscience	2023	Prenatal alcohol exposure dysregulates spinal and circulating immune cell circular RNA expression in adult female rats with chronic sciatic neuropathy.		circItch	rno_circ_Itch	Itch	Fetal Alcohol Spectrum Disorders / FASD	MONDO:0000408	fetal alcohol spectrum disorder	down-regulated	RT-qPCR; Microarray	"circItch is downregulated in the spinal cord of adult female PAE rats, particularly after minor sciatic nerve injury associated with allodynia. The study links circItch to immune regulation/inflammation in the context of PAE-induced neuroimmune dysregulation, though the specific mechanistic interactions were not experimentally mapped here."	0.5608
37360167	Frontiers in neuroscience	2023	Prenatal alcohol exposure dysregulates spinal and circulating immune cell circular RNA expression in adult female rats with chronic sciatic neuropathy.		circRps6ka3 / circRp6ka3	rno_circ_Rps6ka3		Fetal Alcohol Spectrum Disorders / FASD	MONDO:0000408	fetal alcohol spectrum disorder	down-regulated	RT-qPCR; Microarray	"circRps6ka3 (circRp6ka3) is downregulated in the spinal cord of adult female rats exposed to prenatal alcohol, validated by RT-qPCR. It is highlighted as an immune/allodynia-associated circRNA in this model, but the study does not establish a specific downstream miRNA/target axis for it."	0.5608
37361693	International journal of genomics	2023	Hsa_circ_0003220 Drives Chemoresistance of Human NSCLC Cells by Modulating miR-489-3p/IGF1.	hsa_circ_0003220		hsa_circ_TMCO7	TMCO7	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0003220 is up-regulated in paclitaxel-resistant NSCLC tissues and cell lines and promotes proliferation and resistance to PTX/DDP/DTX. Mechanistically, it sponges miR-489-3p to increase IGF1 expression (miR-489-3p/IGF1 axis). High hsa_circ_0003220 expression correlates with shorter overall survival in NSCLC patients."	0.7238
37363990	Cancer research	2023	Mutant KRAS Mediates circARFGEF2 Biogenesis to Promote Lymphatic Metastasis of Pancreatic Ductal Adenocarcinoma.	hsa_circ_0060665	circARFGEF2	hsa_circ_ARFGEF2	ARFGEF2	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circARFGEF2 (hsa_circ_0060665), produced from ARFGEF2, is up-regulated in KRASG12D PDAC and correlates with lymph node metastasis and poor survival. It primarily localizes to the cytoplasm and acts as a ceRNA to sponge miR-1205, thereby increasing JAK2 expression and activating JAK2_STAT3 signaling to promote lymphangiogenesis and LN metastasis. Its biogenesis is enhanced by QKI-5-dependent splicing involving U2AF35, and silencing circARFGEF2 suppresses metastasis in xenograft and KPC models."	0.8941
37366063	Journal of biomedical research	2023	"Circular RNA expression and the competitive endogenous RNA network in pathological, age-related macular degeneration events: A cross-platform normalization study."	hsa_circ_0003353		hsa_circ_TFPI	TFPI	age-related macular degeneration / AMD	MONDO:0005150	age-related macular degeneration	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0003353 is down-regulated in both oxidative stress (H2O2) and inflammatory (TNF-alpha) ARPE-19 AMD cell models and is included in the study¡¯s predicted circRNA_miRNA_mRNA ceRNA network whose downstream enrichment highlights HIF-1 signaling as a common event.	0.3684
37366063	Journal of biomedical research	2023	"Circular RNA expression and the competitive endogenous RNA network in pathological, age-related macular degeneration events: A cross-platform normalization study."	hsa_circ_0095556		hsa_circ_NAV2	NAV2	age-related macular degeneration / AMD	MONDO:0005150	age-related macular degeneration	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0095556 is down-regulated in both oxidative stress and inflammatory ARPE-19 AMD models and is part of the predicted circRNA_miRNA_mRNA ceRNA network constructed in this study, with downstream enrichment implicating HIF-1 signaling as a common event."	0.2465
37366063	Journal of biomedical research	2023	"Circular RNA expression and the competitive endogenous RNA network in pathological, age-related macular degeneration events: A cross-platform normalization study."	hsa_circ_0001400		hsa_circ_RELL1	RELL1	age-related macular degeneration / AMD	MONDO:0005150	age-related macular degeneration	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001400 is up-regulated in both oxidative stress and inflammatory ARPE-19 AMD models and is part of the predicted circRNA_miRNA_mRNA ceRNA network constructed in this study, whose downstream enrichment highlights HIF-1 signaling as a common event."	0.2465
37370086	Journal of biomedical science	2023	Circular RNA FEACR inhibits ferroptosis and alleviates myocardial ischemia/reperfusion injury by interacting with NAMPT.		circRNA0008180 / FEACR	mmu_circ_FBXW4	FBXW4	myocardial ischemia/reperfusion injury	MONDO:0005203	ischemia reperfusion injury	down-regulated	RT-qPCR; RNA-seq	"In mouse myocardial I/R (and cardiomyocyte H/R), FEACR is downregulated and functions as a ferroptosis-suppressive circRNA. FEACR binds NAMPT and increases its protein stability, thereby activating the NAMPT_Sirt1_FOXO1_FTH1 axis to inhibit ferroptosis and reduce cardiac injury."	0.7809
37370759	Cancers	2023	METTL3-Modulated circUHRF2 Promotes Colorectal Cancer Stemness and Metastasis through Increasing DDX27 mRNA Stability by Recruiting IGF2BP1.	hsa_circ_0002359	circUHRF2	hsa_circ_UHRF2	UHRF2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circUHRF2 is upregulated in colorectal cancer and is mainly localized in the cytoplasm. It promotes CRC stemness and metastasis by binding IGF2BP1 to enhance DDX27 mRNA stability and maintain DDX27 protein, and its expression is increased by METTL3-mediated m6A modification and correlates with poor survival."	0.8912
37372440	Genes	2023	Circ_PIAS1 Promotes the Apoptosis of ALV-J Infected DF1 Cells by Up-Regulating miR-183.		circ_PIAS1 / circRNA_PIAS1	gga_circ_PIAS1	PIAS1	ALV-J infection	MONDO:0005108	viral infectious disease	up-regulated	RT-qPCR	"In ALV-J-infected DF-1 chicken fibroblast cells, circ_PIAS1 promotes apoptosis. Mechanistically, circ_PIAS1 binds miR-183 and increases miR-183 expression, and this circ_PIAS1_miR-183 relationship contributes to apoptosis during ALV-J infection."	0.5802
37379126	Aging	2023	Comprehensive analysis reveals the involvement of hsa_circ_0037858/miR-5000-3p/FMR1 axis in malignant metastasis of clear cell renal cell carcinoma.	hsa_circ_0037858	ASCRP3006810	hsa_circ_LITAF	LITAF	clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	down-regulated	Microarray	"In ccRCC, hsa_circ_0037858 is down-regulated and acts as a metastasis-suppressive circRNA in vitro. It is proposed to function through a hsa_circ_0037858/miR-5000-3p/FMR1 regulatory axis, where miR-5000-3p overexpression reverses hsa_circ_0037858-mediated FMR1 upregulation and anti-migration effects."	0.4474
37381158	Clinical and translational medicine	2023	ALKBH5/YTHDF2-mediated m6A modification of circAFF2 enhances radiosensitivity of colorectal cancer by inhibiting Cullin neddylation.	hsa_circ_0001947	circAFF2	hsa_circ_AFF2	AFF2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"In colorectal/rectal cancer, circAFF2 is upregulated in radiosensitive tumors and promotes radiosensitivity by increasing radiation-induced DNA damage responses and apoptosis. It is regulated by m6A dynamics (ALKBH5-mediated demethylation and YTHDF2-dependent decay) and mechanistically binds CAND1 to strengthen CAND1_Cullin1 interaction, thereby inhibiting Cullin neddylation. High circAFF2 expression correlates with better disease-free survival in rectal cancer patients receiving neoadjuvant chemoradiotherapy."	0.894
37382271	"Immunity, inflammation and disease"	2023	Circ_0035292 knockdown alleviates lipopolysaccharide (LPS)-induced WI-38 cell apoptosis and inflammatory injury.	hsa_circ_0035292	circ_0035292 / circTMOD3	hsa_circ_TMOD3	TMOD3	infantile pneumonia / IP	MONDO:0005249	pneumonia	up-regulated	RT-qPCR	"circ_0035292 is up-regulated in serum from infantile pneumonia patients and in LPS-treated WI-38 cells. Its knockdown alleviates LPS-induced apoptosis and inflammatory cytokine production and restores proliferation, mainly by sponging miR-370-3p to de-repress TBL1XR1 and modulate NF-kappaB signaling."	0.7591
37384727	PloS one	2023	Exosome-delivered circRPS5 inhibits the progression of melanoma via regulating the miR-151a/NPTX1 axis.	hsa_circ_0052351	circRPS5	hsa_circ_RPS5	RPS5	melanoma	MONDO:0005105	melanoma	down-regulated	RT-qPCR; RNA-seq	"circRPS5 is down-regulated in melanoma and acts as a tumor suppressor by inhibiting proliferation, migration and invasion while promoting apoptosis and G1/S arrest. It primarily localizes to the cytoplasm, functions as a ceRNA sponging miR-151a to increase NPTX1 expression, and is mainly packaged into exosomes to mediate extracellular inhibitory effects on melanoma cells."	0.8
37385973	Thoracic cancer	2023	Knockdown of circADAM9 inhibits cell progression and glycolysis by targeting the miR-1236-3p/FGF7 axis in breast cancer.		circADAM9	hsa_circ_ADAM9	ADAM9	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circADAM9 is up-regulated in breast cancer tissues and cell lines and mainly localizes in the cytoplasm. It promotes malignant behaviors and glycolysis and inhibits apoptosis by sponging miR-1236-3p to upregulate FGF7, and its knockdown suppresses tumor growth in a cell line-derived xenograft model."	0.8327
37386831	The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology	2023	Circ-SNX27 sponging miR-375/RPN1 axis contributes to hepatocellular carcinoma progression.	hsa_circ_0014188	circ-SNX27	hsa_circ_SNX27	SNX27	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ-SNX27 is up-regulated in HCC tissues and cell lines and functions as an oncogenic circRNA. It mainly localizes to the cytoplasm, sponges miR-375, and thereby upregulates RPN1, promoting proliferation and invasion while inhibiting apoptosis and enhancing xenograft tumor growth."	0.6996
37389236	World journal of gastroenterology	2023	Plasma exosomal hsa_circ_0079439 as a novel biomarker for early detection of gastric cancer.	hsa_circ_0079439				gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"Plasma exosomal hsa_circ_0079439 is upregulated in gastric cancer (including early and advanced stages) and shows strong diagnostic performance versus standard serum biomarkers. Its level decreases after treatment, supporting its use as a liquid-biopsy biomarker for GC detection and monitoring."	0.636
37393232	Journal of orthopaedic surgery and research	2023	"CircTBX5 knockdown modulates the miR-558/MyD88 axis to alleviate IL-1beta-induced inflammation, apoptosis and extracellular matrix degradation in chondrocytes via inactivating the NF-kappaB signaling."	hsa_circ_0003176	circTBX5 / circ_0003176	hsa_circ_TBX5	TBX5	osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"CircTBX5 is up-regulated in OA cartilage and IL-1beta-treated C28/I2 chondrocytes. Functionally, circTBX5 knockdown alleviates IL-1beta-induced injury (reduced inflammation, apoptosis, and ECM degradation; improved viability/proliferation) by sponging miR-558 to downregulate MyD88 and inactivate NF-kappaB signaling."	0.8275
37393311	Molecular cancer	2023	Enhancement of TKI sensitivity in lung adenocarcinoma through m6A-dependent translational repression of Wnt signaling by circ-FBXW7.	hsa_circ_0001451 	circFBXW7 / circFBXW7-185AA	hsa_circ_FBXW7	FBXW7	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; RNA-seq; Microarray	"circFBXW7 is down-regulated in Osimertinib-resistant LUAD cells/stem-like cells and its abnormal level affects drug response. It can be translated (m6A/YTHDF3-dependent) into circFBXW7-185AA, which binds beta-catenin, increases its ubiquitination, suppresses canonical Wnt/beta-catenin signaling, inhibits stem-cell self-renewal, and resensitizes cells to Osimertinib. The study also implicates a feedback loop involving Wnt signaling, Let-7d, and YTHDF3 that influences circFBXW7 translation/expression."	0.8035
37394466	Cancer cell international	2023	Exosome-derived circKIF20B suppresses gefitinib resistance and cell proliferation in non-small cell lung cancer.	hsa_circ_0019079	Circ_0019079 / circKIF20B	hsa_circ_KIF20B	KIF20B	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	"CircKIF20B (hsa_circ_0019079) is down-regulated in NSCLC tumor tissues and in serum exosomes from gefitinib-resistant patients. It suppresses proliferation and gefitinib resistance by acting as a ceRNA sponge for miR-615-3p to increase MEF2A, leading to cell-cycle arrest, enhanced apoptosis, and reduced mitochondrial OXPHOS; exosomal delivery of circKIF20B can restore gefitinib sensitivity in recipient cells."	0.8816
37397256	Frontiers in cell and developmental biology	2023	Gene SH3BGRL3 regulates acute myeloid leukemia progression through circRNA_0010984 based on competitive endogenous RNA mechanism.	hsa_circ_0010984	circRNA_0010984 / circSH3BGRL3	hsa_circ_SH3BGRL3	SH3BGRL3	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"circRNA_0010984 (circSH3BGRL3) is up-regulated in AML peripheral blood leukocytes and promotes AML cell proliferation and cell-cycle progression. Mechanistically, it sponges miR-375 to upregulate YAP1 and activate Hippo/YAP signaling, and its knockdown increases AML cell sensitivity to daunorubicin."	0.8468
37398901	"Open medicine (Warsaw, Poland)"	2023	circNFATC3 facilitated the progression of oral squamous cell carcinoma via the miR-520h/LDHA axis.	hsa_circ_0005615	circNFATC3	hsa_circ_NFATC3	NFATC3	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circNFATC3 is up-regulated in OSCC tissues/cells and functions as an oncogenic circRNA. It promotes glycolysis, proliferation, migration and invasion and inhibits apoptosis by sponging miR-520h to de-repress LDHA; circNFATC3 knockdown suppresses xenograft tumor growth in vivo."	0.8593
37400785	BMC cancer	2023	Upregulation of hsa_circ_0002003 promotes hepatocellular carcinoma progression.	hsa_circ_0002003				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"hsa_circ_0002003 is up-regulated in HCC and promotes proliferation, migration/invasion and metastasis-related phenotypes in liver cancer cells. It mainly localizes to the cytoplasm and acts as a ceRNA by sponging hsa-miR-1343-3p to affect downstream targets including STMN1 (and also DTYMK, DAP3), with the proposed key axis hsa_circ_0002003/hsa-miR-1343-3p/STMN1."	0.798
37400785	BMC cancer	2023	Upregulation of hsa_circ_0002003 promotes hepatocellular carcinoma progression.	hsa_circ_0002454				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"hsa_circ_0002454 was identified as significantly up-regulated in HCC tissues across integrated datasets and was validated by RT-qPCR, but no functional mechanism was investigated or reported in this study."	0.4297
37400785	BMC cancer	2023	Upregulation of hsa_circ_0002003 promotes hepatocellular carcinoma progression.	hsa_circ_0001394				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"hsa_circ_0001394 is up-regulated in HCC tissues and was validated by RT-qPCR; in vitro knockdown in HepG2 cells did not significantly change proliferation in the reported assay, and no mechanism/axis for this circRNA was established in this study."	0.5817
37400900	BMC research notes	2023	Downregulation of circ-Foxo3 in breast cancer stem-like cells.		Circ-Foxo3 / CircFoxo3	mmu_circ_FOXO3	FOXO3	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	"circ-Foxo3 is significantly down-regulated in spheroid-forming breast tumor cells enriched for cancer stem-like cells, and the study suggests this reduction may contribute to apoptosis evasion/apoptotic resistance in breast CSCs."	0.3957
37402719	Nature communications	2023	Defining the landscape of circular RNAs in neuroblastoma unveils a global suppressive function of MYCN.	hsa_circ_0008494	circARID1A / cARID1A	hsa_circ_ARID1A	ARID1A	neuroblastoma / NB	MONDO:0005072	neuroblastoma	up-regulated	RT-qPCR; Northern Blot; ISH; RNA-seq	"circARID1A is a neuroblastoma-enriched circRNA derived from ARID1A and is higher in high-risk MYCN-nonamplified tumors. It promotes neuroblastoma cell proliferation/viability and supports survival, at least partly via direct binding to and stabilization of the RBP KHSRP."	0.8067
37407973	Cancer cell international	2023	CircGNB1 facilitates the malignant phenotype of GSCs by regulating miR-515-5p/miR-582-3p-XPR1 axis.	hsa_circ_0009362	circGNB1	hsa_circ_GNB1	GNB1	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; RNA-seq	"circGNB1 (hsa_circ_0009362), derived from GNB1, is up-regulated in glioma/GBM and predicts shorter survival. It promotes GSC proliferation/viability, invasion and neurosphere formation by sponging miR-515-5p and miR-582-3p to increase XPR1, which enhances IL6 and activates JAK2/STAT3 signaling; IGF2BP3 binds circGNB1 and stabilizes it, reinforcing these oncogenic effects."	0.8794
37408008	Molecular cancer	2023	A novel polypeptide CAPG-171aa encoded by circCAPG plays a critical role in triple-negative breast cancer.	hsa_circ_0055412	circCAPG	hsa_circ_CAPG	CAPG	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"circCAPG is up-regulated in TNBC and promotes malignant phenotypes largely by encoding the peptide CAPG-171aa. CAPG-171aa binds STK38, disrupts STK38_SMURF1 interaction, reduces MEKK2 ubiquitination to stabilize MEKK2, and activates the MEKK2_MEK1/2_ERK1/2 pathway. SLU7 negatively regulates circCAPG biogenesis via binding flanking Alu/ICS sequences; clinically, high circCAPG associates with poor prognosis and shows diagnostic potential (ROC AUC ~0.87)."	0.8941
37408496	Molecular oncology	2023	Expression of circular RNAs in myelodysplastic neoplasms and their association with mutations in the splicing factor gene SF3B1.	hsa_circ_0000228	ZEB1_circRNA	hsa_circ_ZEB1	ZEB1	Myelodysplastic syndrome / MDS	MONDO:0018881	myelodysplastic syndrome	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000228 (a ZEB1-derived circRNA) is strongly up-regulated in SF3B1-mutated MDS. Its knockdown alters cellular metabolism by increasing mitochondrial respiration/oxidative phosphorylation and decreasing glycolysis, and it directly binds miR-1248, consistent with a ceRNA-like mechanism linked to mitochondrial processes."	0.6715
37408496	Molecular oncology	2023	Expression of circular RNAs in myelodysplastic neoplasms and their association with mutations in the splicing factor gene SF3B1.	hsa_circ_0003793	ZEB1_circRNA	hsa_circ_ZEB1	ZEB1	Myelodysplastic syndrome / MDS	MONDO:0018881	myelodysplastic syndrome	up-regulated	RNA-seq	"hsa_circ_0003793 is a ZEB1-derived circRNA up-regulated in SF3B1-mutated MDS (identified by RNA-seq), and its circular back-splice junction was experimentally confirmed (Sanger sequencing) as part of validating upregulated ZEB1 circular transcripts."	0.385
37415611	"Open medicine (Warsaw, Poland)"	2023	Knockdown of circ_0113656 assuages oxidized low-density lipoprotein-induced vascular smooth muscle cell injury through the miR-188-3p/IGF2 pathway.	hsa_circ_0113656	circ_0113656 / circDHCR24	hsa_circ_DHCR24	DHCR24	atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"circ_0113656 (circDHCR24) is up-regulated in blood from atherosclerosis patients and in ox-LDL-treated HVSMCs. It promotes ox-LDL-induced HVSMC proliferation, migration and invasion by sponging miR-188-3p, thereby increasing IGF2; circ_0113656 knockdown alleviates these injury phenotypes via the miR-188-3p/IGF2 axis."	0.7412
37416745	Annals of gastroenterological surgery	2023	Circ_0102543 suppresses hepatocellular carcinoma progression through the miR-942-5p/SGTB axis.	hsa_circ_0102543	circ_0102543 / cricDPF3	hsa_circ_DPF3	DPF3	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"circ_0102543 is down-regulated in HCC tissues/cell lines and functions as a tumor suppressor. It sponges miR-942-5p to de-repress SGTB, thereby inhibiting proliferation, migration, and invasion while promoting apoptosis, and it reduces xenograft tumor growth."	0.8465
37417427	Cancer science	2023	Circular RNA circ-FIRRE interacts with HNRNPC to promote esophageal squamous cell carcinoma progression by stabilizing GLI2 mRNA.	hsa_circ_0001944	circ_FIRRE	hsa_circ_FIRRE	FIRRE	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ-FIRRE is up-regulated in ESCC and promotes malignant phenotypes (proliferation, migration, invasion and tumor growth). It acts in the cytoplasm as a scaffold/decoy for HNRNPC to increase GLI2 mRNA stability via the GLI2 3¡ä-UTR, elevating GLI2 and activating Hedgehog signaling and downstream targets (MYC, CCNE1, CCNE2). High circ-FIRRE is associated with advanced stage and poor overall survival and shows diagnostic potential by ROC analysis."	0.8905
37426414	PeerJ	2023	Development of a circHIPK3-based ceRNA network and identification of mRNA signature in breast cancer patients harboring BRCA mutation.	hsa_circ_0021603	circHIPK3	hsa_circ_HIPK3	HIPK3	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"In BRCA-mutant breast cancer, circHIPK3 (hsa_circ_0021603; host gene HIPK3) is up-regulated in breast cancer cells and promotes cell viability, migration, and invasion. The study also constructed a circHIPK3-centered circRNA_miRNA_mRNA ceRNA network computationally, but did not experimentally validate specific miRNA/mRNA targets for circHIPK3."	0.3957
37426524	JACC. Basic to translational science	2023	RNA m6A-Regulated circ-ZNF609 Suppression Ameliorates Doxorubicin-Induced Cardiotoxicity by Upregulating FTO.			mmu_circ_Znf609	Znf609	DOX-induced cardiotoxicity	MONDO:0004994	cardiomyopathy	up-regulated	RT-qPCR	"In DOX-induced cardiotoxicity models, circ-ZNF609 is upregulated in cardiomyocytes. Silencing circ-ZNF609 protects the heart/cardiomyocytes by reducing apoptosis, oxidative stress, and mitochondrial nonheme iron overload, and it acts in part by upregulating FTO (via inhibiting Fto mRNA degradation) within an m6A-regulated circuit affecting circ-ZNF609 stability."	0.5699
37426804	Heliyon	2023	circSnd1 promotes atherosclerosis progression through the miR-485-3p/Olr1 signaling pathway.	hsa_circ_0082139	circ_0082139 / circSnd1	hsa_circ_SND1	Snd1	atherosclerosis / AS	MONDO:0005311	atherosclerosis	dysregulated	RT-qPCR; Microarray	"circSnd1 is implicated in atherosclerosis models by acting as a ceRNA that sponges miR-485-3p to increase Olr1, thereby promoting macrophage inflammatory responses and altering lipid transport/lipid accumulation. Silencing circSnd1 in vitro and in vivo attenuates AS-related inflammatory factors and plaque-related changes."	0.7283
37426804	Heliyon	2023	circSnd1 promotes atherosclerosis progression through the miR-485-3p/Olr1 signaling pathway.		mus_circSnd1 / circSnd1	mmu_circ_SND1	Snd1	atherosclerosis / AS	MONDO:0005311	atherosclerosis	dysregulated	RT-qPCR; Microarray	"circSnd1 is implicated in atherosclerosis models by acting as a ceRNA that sponges miR-485-3p to increase Olr1, thereby promoting macrophage inflammatory responses and altering lipid transport/lipid accumulation. Silencing circSnd1 in vitro and in vivo attenuates AS-related inflammatory factors and plaque-related changes."	0.7283
37428781	PloS one	2023	The possible molecular mechanism underlying the involvement of the variable shear factor QKI in the epithelial-mesenchymal transformation of oesophageal cancer.	hsa_circ_0006646	hsa_ circBACH1_ 012	hsa_circ_BACH1	BACH1	oesophageal cancer	MONDO:0019086	carcinoma of esophagus	up-regulated	RNA-seq	"In oesophageal cancer, hsa_circ_0006646 (from host gene BACH1) is predicted to be upregulated and promoted by QKI-regulated alternative splicing. It may act as a ceRNA by binding multiple miRNAs, thereby de-repressing EMT-related genes (IL11, MFAP2, MMP10, MMP1) and promoting EMT."	0.1768
37428781	PloS one	2023	The possible molecular mechanism underlying the involvement of the variable shear factor QKI in the epithelial-mesenchymal transformation of oesophageal cancer.	hsa_circ_0061395		hsa_circ_PTK2	PTK2	oesophageal cancer	MONDO:0019086	carcinoma of esophagus	up-regulated	RNA-seq	"In oesophageal cancer, hsa_circ_0061395 (from host gene PTK2) is predicted to be upregulated and promoted by QKI-regulated alternative splicing. It may act as a ceRNA by sponging several miRNAs, thereby de-repressing EMT-related genes (IL11, MFAP2, MMP10, MMP1) and promoting EMT."	0.1768
37431262	Turkish journal of haematology : official journal of Turkish Society of Haematology	2023	Circ_0001946 Promotes the Development of Acute Myeloid Leukemia by Upregulating PDL1.	hsa_circ_0001946	Circ_0001946			acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"circ_0001946 is up-regulated in AML patient bone marrow samples and AML cell lines. Functionally, it promotes AML cell proliferation, migration, and invasion. Mechanistically, circ_0001946 binds PDL1 and enhances PDL1 mRNA stability, increasing PDL1 expression and driving malignant phenotypes."	0.7646
37434183	Immunity & ageing : I & A	2023	Blood RNA-Seq profiling reveals a set of circular RNAs differentially expressed in frail individuals.	hsa_circ_0007817				Frailty			up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0007817 is up-regulated in leukocytes from frail individuals and shows strong diagnostic potential to discriminate frail from robust participants, including as part of a multi-circRNA signature."	0.6193
37434183	Immunity & ageing : I & A	2023	Blood RNA-Seq profiling reveals a set of circular RNAs differentially expressed in frail individuals.	hsa_circ_0101802				Frailty			up-regulated	RT-qPCR; RNA-seq	hsa_circ_0101802 is up-regulated in leukocytes from frail individuals and is part of a multi-circRNA signature with diagnostic value for frailty; its level shows a non-significant reduction trend after physical intervention.	0.6193
37434183	Immunity & ageing : I & A	2023	Blood RNA-Seq profiling reveals a set of circular RNAs differentially expressed in frail individuals.	hsa_circ_0060527				Frailty			up-regulated	RT-qPCR; RNA-seq	hsa_circ_0060527 is up-regulated in leukocytes from frail individuals and contributes to multi-circRNA signatures with diagnostic value for frailty.	0.6193
37434183	Immunity & ageing : I & A	2023	Blood RNA-Seq profiling reveals a set of circular RNAs differentially expressed in frail individuals.	hsa_circ_0075737				Frailty			up-regulated	RT-qPCR; RNA-seq	hsa_circ_0075737 is up-regulated in leukocytes from frail individuals and is a component of a high-performing multi-circRNA diagnostic model for frailty.	0.6841
37434183	Immunity & ageing : I & A	2023	Blood RNA-Seq profiling reveals a set of circular RNAs differentially expressed in frail individuals.	hsa_circ_0079284				Frailty			unknown	RT-qPCR	"hsa_circ_0079284 is part of a high-performing circRNA biomarker combination for frailty and is significantly reduced after a 3-month physical intervention, aligning with improved frailty scores; baseline differential expression between frail and robust is not stated in the provided text."	0.459
37435216	Journal of gastrointestinal oncology	2023	Function of hsa_circ_0006646 as a competing endogenous RNA to promote progression in gastric cancer by regulating the miR-665-HMGB1 axis.	hsa_circ_0006646		hsa_circ_PTK2	PTK2	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0006646 (from PTK2) is up-regulated in gastric cancer and promotes tumor cell proliferation, migration, invasion and EMT. Mechanistically, it functions as a ceRNA that sponges miR-665 to increase HMGB1, thereby activating Wnt/beta-catenin signaling. High hsa_circ_0006646 expression is associated with advanced clinicopathologic features and poorer overall survival."	0.8768
37439026	Thoracic cancer	2023	2-methoxyestradiol restrains non-small cell lung cancer tumorigenesis through regulating circ_0010235/miR-34a-5p/NFAT5 axis.	hsa_circ_0010235	circ_0010235			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0010235 is up-regulated in NSCLC tissues and cells and promotes malignant phenotypes. It sponges miR-34a-5p to upregulate NFAT5, and its knockdown suppresses xenograft tumor growth and enhances the antitumor effect of 2-MeOE2."	0.7487
37441407	Heliyon	2023	CircSFMBT2-OA alleviates chondrocyte apoptosis and extracellular matrix degradation through repressing NF-kappaB/NLRP3 inflammasome activation.	hsa_circ_0017636	circSFMBT2-OA	hsa_circ_SFMBT2	SFMBT2	osteoarthritis / OA	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR	"circSFMBT2-OA (has_circ_0017636), a SFMBT2-derived circRNA, is decreased in osteoarthritis cartilage. Its overexpression protects LPS-injured chondrocytes by promoting proliferation and inhibiting apoptosis, inflammatory cytokine production, and ECM degradation, at least partly via suppressing NF-kappaB/NLRP3 inflammasome activation."	0.7507
37442983	BMC pulmonary medicine	2023	Significant role of circRNA BBS9 in chronic obstructive pulmonary disease via miRNA-103a-3p/BCL2L13.		circRNA BBS9 / circRNA-BBS9	hsa_circ_BBS9	BBS9	chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR	"circRNA BBS9 is up-regulated in a CSE-induced COPD cell model and promotes endothelial cell apoptosis. Mechanistically, it sponges miRNA-103a-3p to derepress the downstream target BCL2L13, forming a circRNA BBS9/miRNA-103a-3p/BCL2L13 axis that drives apoptosis."	0.5554
37443201	Communications biology	2023	Circular RNA RSU1 promotes retinal vascular dysfunction by regulating miR-345-3p/TAZ.	hsa_circ_0006577	circRSU1 / circ_0006577	hsa_circ_RSU1	RSU1	diabetic retinopathy / DR	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR; Microarray	"circRSU1 is upregulated in diabetic retinopathy and in high-glucose-treated HRVECs. It promotes endothelial proliferation/migration/invasion and retinal vascular dysfunction by sponging miR-345-3p and increasing TAZ expression, with downstream increases in VEGF and inflammatory/oxidative stress responses."	0.8817
37444485	Cancers	2023	Tumor-Associated Fibroblast-Derived Exosomal circDennd1b Promotes Pituitary Adenoma Progression by Modulating the miR-145-5p/ONECUT2 Axis and Activating the MAPK Pathway.	hsa_circ_0006324	circDennd1b	hsa_circ_DENND1B	Dennd1b	pituitary adenoma / PA	MONDO:0006373	pituitary gland adenoma	up-regulated	RT-qPCR	"TAF-derived exosomal circDennd1b is up-regulated in pituitary adenoma and promotes tumor cell proliferation, migration, and invasion. It functions as a ceRNA by sponging miR-145-5p to upregulate ONECUT2, which transcriptionally induces FGFR3 and activates MAPK signaling to drive PA progression."	0.795
37449524	International journal of oncology	2023	circRPS19 affects HK2_mediated aerobic glycolysis and cell viability via the miR_125a_5p/USP7 pathway in gastric cancer.		circRPS19 / circRNA_102561	hsa_circ_RPS19	RPS19	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circRPS19 is upregulated in gastric cancer cells and promotes tumor cell proliferation and aerobic glycolysis while inhibiting apoptosis. Mechanistically, it sponges miR-125a-5p to increase USP7, which deubiquitinates and stabilizes HK2 protein, enhancing glycolysis and GC progression in vitro and in vivo."	0.8546
37453970	Journal of cancer research and clinical oncology	2023	A novel CircRNA Circ_0001722 regulates proliferation and invasion of osteosarcoma cells through targeting miR-204-5p/RUNX2 axis.	hsa_circ_0001722	Circ_0001722 / circ_001722			Osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"circ_0001722 (circ_001722) is up-regulated in osteosarcoma tissues/cells and functions as an oncogenic circRNA by sponging miR-204-5p, thereby relieving repression of RUNX2 and promoting osteosarcoma cell proliferation and invasion in vitro and tumor growth in vivo."	0.8267
37455373	Thoracic cancer	2023	Circular RNA circ_0000376 promotes paclitaxel resistance and tumorigenesis of non-small cell lung cancer via positively modulating KPNA4 by sponging miR-1298-5p.	hsa_circ_0000376	Circ_0000376	hsa_circ_RPH1		non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0000376 is up-regulated in paclitaxel-resistant NSCLC tissues and cells and promotes PTX resistance and malignant phenotypes. Mechanistically, it sponges miR-1298-5p to increase KPNA4 expression, enhancing tumor growth and reducing chemosensitivity in vitro and in xenograft models."	0.795
37456162	Experimental and therapeutic medicine	2023	Protective effects of hsa_circ_0072568 on interleukin_1beta_stimulated human chondrocytes are mediated via the miR_382_5p/TOP1 axis.	hsa_circ_0072568	circ0072568	hsa_circ_PDE4E	PDE4E	osteoarthritis / OA	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR	"In osteoarthritis cartilage and IL-1beta-stimulated primary human chondrocytes, circ0072568 is down-regulated and exerts protective effects by reducing inflammation, apoptosis, and ECM degradation. Mechanistically, circ0072568 mainly localizes to the cytoplasm and functions as a ceRNA that sponges miR-382-5p to upregulate TOP1, forming a circ0072568/miR-382-5p/TOP1 regulatory axis."	0.7785
37457110	"Diabetes, metabolic syndrome and obesity : targets and therapy"	2023	A Novel Circ_Arf3/miR-452-5p/Mbnl1 Axis Regulates Proliferation and Expression of Fibrosis-Related Proteins of Mouse Mesangial Cells Under High Glucose.	mmu_circ_0000650	circ_Arf3 / circ_0000650	mmu_circ_Arf3	Arf3	Diabetic nephropathy / DN	MONDO:0005016	diabetic kidney disease	down-regulated	RT-qPCR	"In a high glucose-induced in vitro diabetic nephropathy model using mouse mesangial cells, circ_Arf3 is down-regulated and functions as a cytoplasmic/nuclear circRNA with a stable circular structure. circ_Arf3 suppresses HG-induced mesangial cell proliferation and fibrosis-related protein expression by sponging miR-452-5p and thereby relieving repression of the miR-452-5p target Mbnl1."	0.7406
37459535	Proceedings of the National Academy of Sciences of the United States of America	2023	Cytoskeleton remodeling mediated by circRNA-YBX1 phase separation suppresses the metastasis of liver cancer.	hsa_circ_0006302	circASH2 / circular RNA ASH2	hsa_circ_ASH2	ASH2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; ISH; Microarray	"circASH2 is down-regulated in HCC and acts as a nuclear tumor-suppressive circRNA that inhibits metastasis by impairing cytoskeleton/adhesion. It binds TPM4 transcripts and promotes YBX1 LLPS to assemble a YBX1/hnRNP complex, driving splicing-coupled NMD and decay of TPM4, thereby suppressing FAK/PI3K/AKT-associated motility programs."	0.8778
37461019	Breast cancer research : BCR	2023	Chemotherapy-induced exosomal circBACH1 promotes breast cancer resistance and stemness via miR-217/G3BP2 signaling pathway.		circBACH1	hsa_circ_BACH1	BACH1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Northern Blot; Microarray	"circBACH1 is upregulated in paclitaxel-induced breast-cancer-derived exosomes and in breast cancer tissues, and it promotes PTX resistance, stemness, migration and angiogenesis. Mechanistically, exosomal circBACH1 acts as a ceRNA that sponges miR-217 to increase G3BP2 expression (circBACH1/miR-217/G3BP2)."	0.7786
37461053	Journal of experimental & clinical cancer research : CR	2023	Energy stress-induced circZFR enhances oxidative phosphorylation in lung adenocarcinoma via regulating alternative splicing.	hsa_circ_0072088	circZFR	hsa_circ_ZFR	ZFR	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"In LUAD, circZFR (hsa_circ_0072088) is induced by glucose deprivation and is upregulated in tumors. It promotes OXPHOS and malignant phenotypes by binding and stabilizing HNRNPLL (blocking ubiquitination), thereby altering alternative splicing (including MYO1B exon 23 inclusion) and activating AKT-mTOR signaling; high circZFR correlates with advanced T stage and poor prognosis."	0.8988
37465349	"Open medicine (Warsaw, Poland)"	2023	circRNA THBS1 silencing inhibits the malignant biological behavior of cervical cancer cells via the regulation of miR-543/HMGB2 axis.		circRNA THBS1	hsa_circ_THBS1	THBS1	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circRNA THBS1 is upregulated in cervical cancer tissues and cell lines and functions as an oncogenic circRNA. It sponges miR-543 to relieve repression of HMGB2, thereby promoting viability/proliferation and EMT while inhibiting apoptosis in cervical cancer cells."	0.6479
37465351	"Open medicine (Warsaw, Poland)"	2023	hsa_circ_0000285 sponging miR-582-3p promotes neuroblastoma progression by regulating the Wnt/beta-catenin signaling pathway.	hsa_circ_0000285	circ_0000285	hsa_circ_HIPK3	HIPK3	neuroblastoma / NB	MONDO:0005072	neuroblastoma	up-regulated	RT-qPCR	"circ_0000285 (hsa_circ_0000285), derived from HIPK3, is up-regulated in neuroblastoma tissues and cell lines and mainly localized in the cytoplasm. It promotes neuroblastoma proliferation, migration and tumor growth while inhibiting apoptosis by sponging miR-582-3p and thereby enhancing Wnt/beta-catenin signaling activity."	0.7631
37468464	Cell death discovery	2023	"circRNF13, a novel N6-methyladenosine-modified circular RNA, enhances radioresistance in cervical cancer by increasing CXCL1 mRNA stability."	hsa_circ_0001346	circRNF13	hsa_circ_RNF13	RNF13	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; RNA-seq	"circRNF13 (hsa_circ_0001346), derived from RNF13, is up-regulated in radioresistant cervical cancer tissues/cells and promotes radioresistance. Mechanistically, it increases CXCL1 mRNA stability, while its own abundance is regulated by METTL3/YTHDF2-mediated m6A modification and degradation."	0.8564
37468993	Journal of ovarian research	2023	Expression of circ-PHC3 enhances ovarian cancer progression via regulation of the miR-497-5p/SOX9 pathway.	hsa_circ_0005228	circ-PHC3	hsa_circ_PHC3	PHC3	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; RNA-seq	"circ-PHC3 (hsa_circ_0005228), derived from the PHC3 gene, is up-regulated in ovarian cancer tissues and cell lines. Functional assays show circ-PHC3 promotes proliferation, migration/invasion, tumor growth and metastasis, and supports stemness-related phenotypes. Mechanistically, it acts as a ceRNA by sponging miR-497-5p to increase SOX9 expression (circ-PHC3/miR-497-5p/SOX9 axis)."	0.7416
37474520	Cell death & disease	2023	Exosomal circTGFBR2 promotes hepatocellular carcinoma progression via enhancing ATG5 mediated protective autophagy.	hsa_circ_0005224	circTGFBR2 / circ_0005224	hsa_circ_TGFBR2	TGFBR2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"Exosomal circTGFBR2 (hsa_circ_0005224) is enriched under starvation stress and is upregulated in HCC patient samples (especially TAE+). It promotes HCC progression by sponging miR-205-5p to upregulate ATG5, enhancing protective autophagy and increasing starvation resistance, proliferation, and tumor growth."	0.8791
37474578	Cell death & disease	2023	circSLC4A7 accelerates stemness and progression of gastric cancer by interacting with HSP90 to activate NOTCH1 signaling pathway.	hsa_circ_0064618	circSLC4A7 / circ0064618	hsa_circ_SLC4A7	SLC4A7	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"circSLC4A7 is up-regulated in gastric cancer stem-like spheroid cells and GC tissues/cell lines. It promotes CSC-like properties and malignant phenotypes (proliferation, migration, invasion) by physically binding HSP90 and activating NOTCH1/Notch signaling."	0.8416
37479790	Scientific reports	2023	Identification of autophagy-associated circRNAs in sepsis-induced cardiomyopathy of mice.		circRNA.27393 / circRNA_27393	mmu_circ_Pfkfb3	Pfkfb3	sepsis-induced cardiomyopathy / SICM	MONDO:0004994	cardiomyopathy	up-regulated	RT-qPCR; Microarray	"In LPS-induced sepsis-induced cardiomyopathy mouse hearts, circRNA.27393 is up-regulated and predicted to act as a ceRNA/miRNA sponge. It may modulate autophagy-related genes (e.g., Dap, rnf152, Ajuba) via binding mmu-miR-1933-3p, mmu-miR-448-5p, mmu-miR-125a-5p and mmu-miR-125b-5p, linking it to autophagy-associated pathways such as Hippo and mTOR."	0.3684
37479790	Scientific reports	2023	Identification of autophagy-associated circRNAs in sepsis-induced cardiomyopathy of mice.		circRNA.22171 / circRNA_22171	mmu_circ_Car8	Car8	sepsis-induced cardiomyopathy / SICM	MONDO:0004994	cardiomyopathy	down-regulated	RT-qPCR; Microarray	circRNA.22171 is significantly down-regulated in LPS-induced sepsis-induced cardiomyopathy mouse myocardium and was validated by RT-qPCR. The study did not further define its downstream miRNA/mRNA interactions or functional mechanism.	0.3213
37479790	Scientific reports	2023	Identification of autophagy-associated circRNAs in sepsis-induced cardiomyopathy of mice.	mmu_circ_0006655		mmu_circ_Fkbp5	Fkbp5	sepsis-induced cardiomyopathy / SICM	MONDO:0004994	cardiomyopathy	up-regulated	Microarray	"mmu_circ_0006655 is up-regulated in LPS-induced SICM mouse myocardium and was included among circRNAs used to construct a predicted ceRNA network, supporting a putative miRNA-sponge regulatory role. No circRNA-specific miRNA/mRNA pairs were experimentally validated for mmu_circ_0006655."	0.31
37481520	Molecular cancer	2023	Extracellular vesicle-circEHD2 promotes the progression of renal cell carcinoma by activating cancer-associated fibroblasts.	hsa_circ_0003146	circEHD2	hsa_circ_EHD2	EHD2	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq; Microarray	"circEHD2 (hsa_circ_0003146), derived from EHD2, is upregulated in ccRCC tissues and enriched in serum EVs from metastatic RCC patients, and high expression is associated with worse OS/PFS. Mechanistically, FUS promotes circEHD2 biogenesis; circEHD2 binds YWHAH and recruits YAP to the SOX9 promoter to sustain SOX9 activation, promoting RCC growth. hnRNPA2B1 mediates circEHD2 loading into EVs, enabling transfer to fibroblasts to induce CAF activation and IL-6 secretion, thereby promoting metastasis; targeting circEHD2 with ASO suppresses tumor growth in vivo."	0.9012
37491214	BMC genomics	2023	CircRNA/lncRNA-miRNA-mRNA network and gene landscape in calcific aortic valve disease.	hsa_circ_0073813				calcific aortic valve disease / CAVD	MONDO:0005463	aortic valve calcification	up-regulated	RT-qPCR; Microarray	"hsa-circ-0073813 is up-regulated in calcified aortic valve disease tissues and is included in a proposed ceRNA network where it may sponge hsa-miR-525-5p to influence hub genes SPP1, HMOX1 and CD28. The specific mechanism was not experimentally dissected beyond expression validation and network construction."	0.4032
37491214	BMC genomics	2023	CircRNA/lncRNA-miRNA-mRNA network and gene landscape in calcific aortic valve disease.	hsa_circ_0027587				calcific aortic valve disease / CAVD	MONDO:0005463	aortic valve calcification	up-regulated	RT-qPCR; Microarray	"hsa-circ-0027587 is up-regulated in CAVD valve tissues and is part of a proposed ceRNA network with hsa-miR-525-5p and hub genes SPP1, HMOX1 and CD28. Its mechanistic role was mainly inferred from bioinformatic ceRNA construction plus expression validation in clinical samples."	0.4032
37491273	Infectious diseases of poverty	2023	Dynamic RNA profiles in the small intestinal epithelia of cats after Toxoplasma gondii infection.		novel_circ_0006558			Toxoplasma gondii infection / toxoplasmosis	MONDO:0005989	toxoplasmosis	up-regulated	RNA-seq	"novel_circ_0006558 is consistently up-regulated in cat small intestinal epithelia across multiple time points after T. gondii infection. It is part of the study¡¯s differentially expressed circRNA set used for downstream predicted ceRNA (circRNA_miRNA_mRNA) network and pathway enrichment analyses, but no specific miRNA/mRNA partners are reported for this circRNA in the provided text."	0.1155
37491273	Infectious diseases of poverty	2023	Dynamic RNA profiles in the small intestinal epithelia of cats after Toxoplasma gondii infection.		novel_circ_0013712			Toxoplasma gondii infection / toxoplasmosis	MONDO:0005989	toxoplasmosis	up-regulated	RNA-seq	"novel_circ_0013712 is consistently up-regulated in cat small intestinal epithelia across multiple time points after T. gondii infection. It is included among the core differentially expressed circRNAs used for predicted circRNA_miRNA_mRNA ceRNA network construction and enrichment analyses, but the provided text does not specify its individual miRNA or mRNA targets."	0.1155
37491273	Infectious diseases of poverty	2023	Dynamic RNA profiles in the small intestinal epithelia of cats after Toxoplasma gondii infection.		novel_circ_0004736			Toxoplasma gondii infection / toxoplasmosis	MONDO:0005989	toxoplasmosis	down-regulated	RNA-seq	"novel_circ_0004736 is consistently down-regulated in cat small intestinal epithelia after T. gondii infection across all sampled time points. It is part of the differentially expressed circRNAs used for predicted ceRNA network and pathway enrichment analyses, but no circRNA-specific targets are provided in the text."	0.1155
37491273	Infectious diseases of poverty	2023	Dynamic RNA profiles in the small intestinal epithelia of cats after Toxoplasma gondii infection.		novel_circ_0014879			Toxoplasma gondii infection / toxoplasmosis	MONDO:0005989	toxoplasmosis	down-regulated	RNA-seq	"novel_circ_0014879 is consistently down-regulated in cat small intestinal epithelia after T. gondii infection across all sampled time points. It is included in the study¡¯s differential circRNA set for predicted ceRNA network/pathway analyses, without circRNA-specific interaction details in the provided text."	0.1155
37491273	Infectious diseases of poverty	2023	Dynamic RNA profiles in the small intestinal epithelia of cats after Toxoplasma gondii infection.		novel_circ_0015045			Toxoplasma gondii infection / toxoplasmosis	MONDO:0005989	toxoplasmosis	down-regulated	RNA-seq	"novel_circ_0015045 is consistently down-regulated in cat small intestinal epithelia after T. gondii infection across all sampled time points. It is used as part of the differentially expressed circRNA set for predicted ceRNA-network/pathway analyses, with no individual target partners described in the provided text."	0.1155
37491273	Infectious diseases of poverty	2023	Dynamic RNA profiles in the small intestinal epithelia of cats after Toxoplasma gondii infection.		novel_circ_0016372			Toxoplasma gondii infection / toxoplasmosis	MONDO:0005989	toxoplasmosis	down-regulated	RNA-seq	"novel_circ_0016372 is down-regulated in cat small intestinal epithelia after T. gondii infection and is included in a predicted circRNA_miRNA_mRNA ceRNA network. It is reported to be connected with bta-miR-1291 and multiple genes in the network, suggesting a potential miRNA-sponge/ceRNA regulatory role during infection."	0.1768
37491273	Infectious diseases of poverty	2023	Dynamic RNA profiles in the small intestinal epithelia of cats after Toxoplasma gondii infection.		novel_circ_0020696			Toxoplasma gondii infection / toxoplasmosis	MONDO:0005989	toxoplasmosis	down-regulated	RNA-seq	"novel_circ_0020696 is down-regulated in cat small intestinal epithelia after T. gondii infection. The paper links it to a predicted ceRNA interaction involving mmu-miR-328-5p and the cat genes PAH and TAT, implicating it in modulation of phenylalanine/tyrosine/tryptophan biosynthesis-related processes during infection."	0.1768
37491273	Infectious diseases of poverty	2023	Dynamic RNA profiles in the small intestinal epithelia of cats after Toxoplasma gondii infection.		novel_circ_0020745			Toxoplasma gondii infection / toxoplasmosis	MONDO:0005989	toxoplasmosis	down-regulated	RNA-seq	"novel_circ_0020745 is consistently down-regulated in cat small intestinal epithelia after T. gondii infection across all sampled time points. It is included among the common differentially expressed circRNAs used for predicted network/enrichment analyses, without specific interaction details in the provided text."	0.1155
37491273	Infectious diseases of poverty	2023	Dynamic RNA profiles in the small intestinal epithelia of cats after Toxoplasma gondii infection.		novel_circ_0021460			Toxoplasma gondii infection / toxoplasmosis	MONDO:0005989	toxoplasmosis	down-regulated	RNA-seq	"novel_circ_0021460 is consistently down-regulated in cat small intestinal epithelia after T. gondii infection across all sampled time points. It is part of the common differentially expressed circRNAs used for predicted ceRNA/network and pathway enrichment analyses, but the provided text does not specify its individual targets."	0.1155
37491357	Journal of orthopaedic surgery and research	2023	Circ-NFKB1 sponges miR-203a-5p to regulate ERBB4 expression and promotes IL-1beta induced chondrocytes apoptosis.		circ-NFKB1	hsa_circ_NFKB1	NFKB1	Osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; Microarray	"circ-NFKB1 is up-regulated in OA cartilage and IL-1beta-treated chondrocytes. It promotes OA-related chondrocyte apoptosis and inflammatory responses by sponging miR-203a-5p, thereby increasing ERBB4 expression; circ-NFKB1 knockdown alleviates OA phenotypes in vitro and in an ACLT rat OA model."	0.7295
37491377	Nature communications	2023	Circular RNA encoded MET variant promotes glioblastoma tumorigenesis.	hsa_circ_0082002	circMET	hsa_circ_MET	MET	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; Northern Blot; RNA-seq	"This study identifies circMET as an m6A-modified circular RNA from the MET gene that is highly expressed in GBM/GSCs. circMET interacts with the m6A reader YTHDF2 to facilitate translation of the MET404 protein, which drives GBM tumorigenesis by constitutively activating MET signaling independent of HGF."	0.8886
37491974	European journal of histochemistry : EJH	2023	Dexmedetomidine attenuates neuroinflammation and microglia activation in LPS-stimulated BV2 microglia cells through targeting circ-Shank3/miR-140-3p/TLR4 axis.		Circ-Shank3 / circshank3	mmu_circ_Shank3	Shank3	postoperative cognitive dysfunction / POCD	MONDO:0002602	central nervous system disorder	up-regulated	RT-qPCR	"In LPS-stimulated BV2 microglia (a POCD-related neuroinflammation model), circ-Shank3 is upregulated and functions as a ceRNA by sponging miR-140-3p, thereby increasing TLR4 and activating TLR4/NF-kappaB signaling. Dexmedetomidine reduces circ-Shank3, leading to increased miR-140-3p and suppression of TLR4/NF-kappaB signaling, which attenuates inflammatory cytokine production and microglia activation markers."	0.593
37494404	PloS one	2023	Circular RNA mediated gene regulation in human breast cancer: A bioinformatics analysis.		hsa_circRNA_407041 / hsa-circRNA-407041	hsa_circ_MSR1	MSR1	breast cancer	MONDO:0007254	breast cancer	down-regulated	Microarray	"hsa_circRNA_407041 is down-regulated in breast cancer and is predicted (via circFunBase-based network analysis) to bind multiple oncogenic/BC-related miRNAs, supporting a putative ceRNA role within the CERNOMA network."	0.1768
37494404	PloS one	2023	Circular RNA mediated gene regulation in human breast cancer: A bioinformatics analysis.		hsa_circRNA_104342 / hsa-circRNA-104342	hsa_circ_BBS9	BBS9	breast cancer	MONDO:0007254	breast cancer	down-regulated	Microarray	"hsa_circRNA_104342 is down-regulated in breast cancer and is predicted to bind miR-15 family members and miR-128-3p, implying a potential ceRNA role within the CERNOMA network."	0.1768
37494404	PloS one	2023	Circular RNA mediated gene regulation in human breast cancer: A bioinformatics analysis.		hsa_circRNA_102908 / hsa-circRNA-102908	hsa_circ_BARD1	BARD1	breast cancer	MONDO:0007254	breast cancer	up-regulated	Microarray	"hsa_circRNA_102908 is up-regulated in breast cancer and is highlighted as part of a predicted ceRNA triplet with miR-410-3p and ESM1, suggesting a regulatory role in tumor-related programs (e.g., dissemination/metastasis via ESM1)."	0.1768
37494404	PloS one	2023	Circular RNA mediated gene regulation in human breast cancer: A bioinformatics analysis.		hsa_circRNA_403236 / hsa-circRNA-403236	hsa_circ_ZNF827	ZNF827	breast cancer	MONDO:0007254	breast cancer	up-regulated	Microarray	"hsa_circRNA_403236 is up-regulated in breast cancer and is predicted to bind miR-29a-3p, potentially influencing extracellular matrix/cell communication programs via miR-29a-3p target genes (e.g., collagens)."	0.1768
37495592	Cell death & disease	2023	Cancer-associated fibroblasts facilitate breast cancer progression through exosomal circTBPL1-mediated intercellular communication.	hsa_circ_0077892	circTBPL1	hsa_circ_TBPL1	TBPL1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	"circTBPL1 (hsa_circ_0077892) is enriched and upregulated in CAF-derived exosomes and can be transferred to breast cancer cells. It promotes malignant phenotypes (proliferation, migration/invasion, EMT, angiogenesis, tumor growth and metastasis) mainly by sponging miR-653-5p to derepress TPBG."	0.872
37496297	Cancer medicine	2023	"Circulating hsa_circ_0072309, acting via the miR-100/ACKR3 pathway, maybe a potential biomarker for the diagnosis, prognosis, and treatment of brain metastasis from non-small-cell lung cancer."	hsa_circ_0072309	circ_0072309			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0072309 is up-regulated in primary lung tumors, brain metastasis tissues, and serum of NSCLC patients with BM. High serum levels correlate with advanced TNM stage, more BM foci, and poorer OS/PFS, and functionally promote BM formation in a mouse model via the miR-100/ACKR3 axis."	0.6806
37496319	Clinical and translational medicine	2023	Hsa_circ_0057105 modulates a balance of epithelial-mesenchymal transition and ferroptosis vulnerability in renal cell carcinoma.	hsa_circ_0057105		hsa_circ_PDK1	PDK1	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"In RCC/ccRCC, hsa_circ_0057105 is up-regulated and mainly localized in the cytoplasm. It promotes migration/invasion and EMT while simultaneously increasing erastin-related ferroptosis sensitivity by sponging miR-577 and derepressing COL1A1 and VDAC2. High expression correlates with advanced stage and predicts poorer OS/RFS."	0.8981
37499410	Translational oncology	2023	CircSLC39A8 attenuates paclitaxel resistance in ovarian cancer by regulating the miR_185_5p/BMF axis.	hsa_circ_0002782	circSLC39A8	hsa_circ_SLC39A8	SLC39A8	ovarian cancer	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR; RNA-seq	"circSLC39A8 (hsa_circ_0002782) is downregulated in paclitaxel-resistant ovarian cancer cells/tissues and increases PTX sensitivity. It mainly localizes in the cytoplasm and functions as a miR-185_5p sponge to derepress the pro-apoptotic target BMF, thereby enhancing apoptosis and G2/M arrest under PTX."	0.8832
37499939	Journal of advanced research	2024	"Hsa_circ_0001402 alleviates vascular neointimal hyperplasia through a miR-183-5p-dependent regulation of vascular smooth muscle cell proliferation, migration, and autophagy."	hsa_circ_0001402		hsa_circ_TBC1D1	TBC1D1	vascular neointimal hyperplasia	MONDO:0005385	vascular disorder	down-regulated	RT-qPCR; Microarray	"hsa_circ_0001402 is decreased in proliferative/migratory VSMCs and functions as a cytoplasmic ceRNA that sponges miR-183-5p. Its overexpression increases FKBPL and BECN1, thereby inhibiting VSMC proliferation/migration, promoting autophagy, and alleviating neointimal hyperplasia; it is also reduced in plasma of unstable angina patients with diagnostic potential."	0.8488
37507742	Journal of translational medicine	2023	Hsa_circ_0002348 regulates trophoblast proliferation and apoptosis through miR-126-3p/BAK1 axis in preeclampsia.	hsa_circ_0002348	circ_0002348	hsa_circ_CRIM1	CRIM1	preeclampsia	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR; ISH	"hsa_circ_0002348 is up-regulated in preeclampsia placentas and correlates with disease severity. It inhibits trophoblast proliferation and promotes trophoblast apoptosis by sponging miR-126-3p to increase BAK1, with involvement of mTOR and ERK1/2 signaling changes."	0.8266
37507775	Pediatric rheumatology online journal	2023	Identifying circRNA-associated-ceRNA networks in juvenile spondyloarthropathies patients.	hsa_circ_0006387		hsa_circ_HERC3	HERC3	juvenile spondyloarthropathies / JSpA	MONDO:0043377	juvenile spondyloarthropathy	down-regulated	Microarray	"hsa_circ_0006387 was identified as a downregulated circRNA in patient PBMC-related datasets and included in the constructed circRNA_miRNA_mRNA ceRNA network for JSpA-related analysis. Its functional impact was inferred computationally via predicted miRNA/mRNA interactions, without experimental validation."	0.1768
37507775	Pediatric rheumatology online journal	2023	Identifying circRNA-associated-ceRNA networks in juvenile spondyloarthropathies patients.	hsa_circ_0005070		hsa_circ_UBR5	UBR5	juvenile spondyloarthropathies / JSpA	MONDO:0043377	juvenile spondyloarthropathy	down-regulated	Microarray	hsa_circ_0005070 was identified as downregulated and incorporated into the JSpA-related circRNA_miRNA_mRNA ceRNA network constructed from GEO microarray datasets. Its role was inferred via bioinformatics prediction rather than experimental validation.	0.1768
37507775	Pediatric rheumatology online journal	2023	Identifying circRNA-associated-ceRNA networks in juvenile spondyloarthropathies patients.	hsa_circ_0001517		hsa_circ_FBXL17	FBXL17	juvenile spondyloarthropathies / JSpA	MONDO:0043377	juvenile spondyloarthropathy	down-regulated	Microarray	hsa_circ_0001517 was downregulated and selected into the final circRNA_miRNA_mRNA network used to study JSpA-associated ceRNA regulation based on GEO microarray and prediction databases. No direct wet-lab functional validation was performed.	0.1768
37507775	Pediatric rheumatology online journal	2023	Identifying circRNA-associated-ceRNA networks in juvenile spondyloarthropathies patients.	hsa_circ_0005303		hsa_circ_SCMH1	SCMH1	juvenile spondyloarthropathies / JSpA	MONDO:0043377	juvenile spondyloarthropathy	down-regulated	Microarray	hsa_circ_0005303 was found downregulated and included in the final JSpA-related ceRNA network built from GEO microarray datasets and target-prediction databases. The study provides only computational evidence for its regulatory involvement.	0.1768
37507775	Pediatric rheumatology online journal	2023	Identifying circRNA-associated-ceRNA networks in juvenile spondyloarthropathies patients.	hsa_circ_0102537				juvenile spondyloarthropathies / JSpA	MONDO:0043377	juvenile spondyloarthropathy	down-regulated	Microarray	"hsa_circ_0102537 was identified as downregulated and incorporated into the final circRNA_miRNA_mRNA network used to infer ceRNA regulation in JSpA. No host gene was reported, and evidence is limited to microarray data and bioinformatics prediction."	0.1768
37509532	Biomedicines	2023	CircAFF1 Is a Circular RNA with a Role in Alveolar Rhabdomyosarcoma Cell Migration.	hsa_circ_0001423	circAFF1 / circular AFF1	hsa_circ_AFF1	AFF1	rhabdomyosarcoma / RMS	MONDO:0005212	rhabdomyosarcoma	up-regulated	RT-qPCR; RNA-seq	"circAFF1 (hsa_circ_0001423) is up-regulated in rhabdomyosarcoma, including ARMS primary biopsies and RMS-derived cell lines. It predominantly localizes in the cytoplasm and functions as a partial suppressor of tumor cell migration; its knockdown increases RH4/RH30 migration, likely via downregulation of adhesion-related genes such as TLR4 and S100A2 rather than via the SAV1/YAP1 (Hippo) axis."	0.7618
37516834	Journal of orthopaedic surgery and research	2023	Hsa_circ_0007292 promotes chondrocyte injury in osteoarthritis via targeting the miR-1179/HMGB1 axis.	hsa_circ_0007292		hsa_circ_ATP5C1	ATP5C1	osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; Microarray	"In osteoarthritis cartilage and IL-1beta-induced human chondrocytes, hsa_circ_0007292 is up-regulated and aggravates chondrocyte injury by promoting apoptosis, inflammation and ECM degradation. It functions as a ceRNA that sponges miR-1179, thereby upregulating HMGB1; knockdown of hsa_circ_0007292 alleviates these OA-like cellular phenotypes."	0.7795
37520722	iScience	2023	circIFNGR2 regulating ankylosing spondylitis-associated inflammation through macrophage polarization.	hsa_circ_0002660	circIFNGR2	hsa_circ_IFNGR2	IFNGR2	ankylosing spondylitis / AS	MONDO:0005306	ankylosing spondylitis	up-regulated	RT-qPCR; RNA-seq	"circIFNGR2 is up-regulated in PBMCs from ankylosing spondylitis patients and correlates with disease activity. It promotes macrophage proliferation and pro-inflammatory M1 polarization while inhibiting M2 polarization by sponging miR-939, thereby enhancing iNOS/TNFalpha expression and modulating NF-kappaB and Akt/mTOR signaling. Its biogenesis is facilitated by the RBP eIF4A3 binding to flanking sequences."	0.7951
37524698	Cell death & disease	2023	circRNA-SFMBT2 orchestrates ERalpha activation to drive tamoxifen resistance in breast cancer cells.	hsa_circ_0017639	circRNA-SFMBT2	hsa_circ_SFMBT2	SFMBT2	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circRNA-SFMBT2 is up-regulated in ER+ breast cancer and further induced by tamoxifen/estrogen deprivation, promoting proliferation and tamoxifen resistance. It binds ERalpha and acts as a scaffold to recruit RNF181, altering ERalpha ubiquitination (decreasing K48-linked while increasing K63-linked) to stabilize ERalpha and enhance ERalpha signaling and target-gene expression."	0.8981
37525152	Cancer cell international	2023	Exosomal hsa_circ_000200 as a potential biomarker and metastasis enhancer of gastric cancer via miR-4659a/b-3p/HBEGF axis.	hsa_circ_0000670	hsa_circ_000200	hsa_circ_ORF72	ORF72	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_000200 is up-regulated in gastric cancer tissues, serum, and serum exosomes, and high levels associate with metastasis-related clinicopathologic features and shorter survival. Functionally, it promotes GC cell proliferation, migration and invasion, and can be transferred via exosomes to enhance malignant behaviors of recipient cells. Mechanistically, it sponges miR-4659a/b-3p to upregulate HBEGF and promote TGF-beta/Smad signaling."	0.8655
37528489	Journal of experimental & clinical cancer research : CR	2023	ZEB1-mediated biogenesis of circNIPBL sustains the metastasis of bladder cancer via Wnt/beta-catenin pathway.	hsa_circ_0001472	circNIPBL	hsa_circ_NIPBL	NIPBL	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circNIPBL is upregulated in bladder cancer and promotes migration, invasion and metastasis. It acts as a ceRNA by sponging miR-16-2-3p to increase Wnt5a and activate Wnt/beta-catenin signaling, upregulating ZEB1 to drive EMT; ZEB1 in turn enhances circNIPBL biogenesis by binding NIPBL flanking introns, forming a positive feedback loop linked to poor prognosis."	0.898
37529258	Turkish journal of biology = Turk biyoloji dergisi	2022	Transcriptome sequencing reveals circRNA expression profile in Parkinson's disease-like mice after aerobic exercise.		circHivep2 /mmu-circHivep2	mmu_circ_Hivep2	HIVEP2	Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	down-regulated	RT-qPCR; RNA-seq	"In MPTP-induced PD-like mice, circHivep2 is down-regulated in the PD group and its decline is restored by aerobic exercise. It is predicted to sponge mmu-miR-3064-5p and is linked to regulation of the target gene Tph1 in a ceRNA network involved in exercise-mediated PD improvement."	0.5297
37529258	Turkish journal of biology = Turk biyoloji dergisi	2022	Transcriptome sequencing reveals circRNA expression profile in Parkinson's disease-like mice after aerobic exercise.		circTshz2 / mmu-circTshz2	mmu_circ_Tshz2	Tshz2	Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	up-regulated	RT-qPCR; RNA-seq	"circTshz2 is up-regulated in the PD group and reduced by aerobic exercise. It participates in an exercise-related ceRNA network, and the circTshz2_mmu-miR-326-3p_Th regulatory relationship is directly validated by dual-luciferase assays."	0.516
37529258	Turkish journal of biology = Turk biyoloji dergisi	2022	Transcriptome sequencing reveals circRNA expression profile in Parkinson's disease-like mice after aerobic exercise.		circZfp827 / mmu-circZfp827	mmu_circ_Zfp827	Zfp827	Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	up-regulated	RT-qPCR; RNA-seq	"circZfp827 is up-regulated in the PD group and reduced by aerobic exercise. It is implicated in a ceRNA network (predicted miRNA sponging) linked to neuronal regulation, and circZfp827 knockdown reduces the predicted target gene Col24a1."	0.4062
37531467	Organogenesis	2023	CircHLA-C: A significantly upregulated circRNA co-existing in oral leukoplakia and oral lichen planus.		circHLA-C	hsa_circ_HLA-C	HLA-C	oral leukoplakia / OLK	MONDO:0004844	oral mucosa leukoplakia	up-regulated	RT-qPCR; RNA-seq	"circHLA-C is significantly up-regulated in OLK and OLP tissues versus normal oral mucosa and shows potential diagnostic value by ROC analysis. Mechanistically, bioinformatics predicts circHLA-C may function as a ceRNA by sponging multiple miRNAs and is linked to immune-related biological processes/pathways in OLK/OLP."	0.6556
37531467	Organogenesis	2023	CircHLA-C: A significantly upregulated circRNA co-existing in oral leukoplakia and oral lichen planus.	hsa_circ_0006801	circRNF13	hsa_circ_RNF13	RNF13	oral leukoplakia / OLK	MONDO:0004844	oral mucosa leukoplakia	up-regulated	RT-qPCR; RNA-seq	"circRNF13 (hsa_circ_0006801) is identified as a co-upregulated circRNA in OLK and OLP compared with normal oral mucosa, and its expression trend is consistent between RNA-seq and RT-qPCR validation. It was also tested for circularity/stability by RNase R assay and subjected to Sanger sequencing in this study."	0.437
37531467	Organogenesis	2023	CircHLA-C: A significantly upregulated circRNA co-existing in oral leukoplakia and oral lichen planus.		circTTN	hsa_circ_TTN	TTN	oral leukoplakia / OLK	MONDO:0004844	oral mucosa leukoplakia	up-regulated	RT-qPCR; RNA-seq	"circTTN is identified as a co-upregulated circRNA in OLK and OLP by high-throughput sequencing and was among the selected circRNAs validated by RT-qPCR. No specific mechanism, interacting miRNAs, or functional assays were reported for circTTN in this study."	0.1904
37531467	Organogenesis	2023	CircHLA-C: A significantly upregulated circRNA co-existing in oral leukoplakia and oral lichen planus.		circSEPN2	hsa_circ_SEPN2	SEPN2	oral leukoplakia / OLK	MONDO:0004844	oral mucosa leukoplakia	down-regulated	RT-qPCR; RNA-seq	circSEPN2 is identified as a co-downregulated circRNA in OLK and OLP by high-throughput sequencing and was among the selected circRNAs validated by RT-qPCR. No specific downstream miRNAs/mRNAs or mechanistic function was reported for circSEPN2 in this study.	0.1904
37531467	Organogenesis	2023	CircHLA-C: A significantly upregulated circRNA co-existing in oral leukoplakia and oral lichen planus.	hsa_circ_0008603	circALDH3A2	hsa_circ_ALDH3A2	ALDH3A2	oral leukoplakia / OLK	MONDO:0004844	oral mucosa leukoplakia	down-regulated	RT-qPCR; RNA-seq	"circALDH3A2 (hsa_circ_0008603) is identified as a co-downregulated circRNA in OLK and OLP by high-throughput sequencing and was among the selected circRNAs validated by RT-qPCR. No specific interacting miRNAs, downstream targets, or functional mechanisms were reported for this circRNA in this study."	0.1904
37532687	Cell death discovery	2023	Circ_0000235 targets MCT4 to promote glycolysis and progression of bladder cancer by sponging miR-330-5p.	hsa_circ_0000235	circ235 / Circ_0000235	hsa_circ_CCNY	CCNY	bladder cancer / Bca	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"hsa_circ_0000235 (circ235) is upregulated in bladder cancer and promotes proliferation, migration, and aerobic glycolysis. Mechanistically, it functions as a ceRNA sponge for miR-330-5p to increase MCT4 expression, enhancing glycolytic metabolism and tumor growth, and higher circ235 correlates with worse prognosis."	0.8912
37533139	Thoracic cancer	2023	Sevoflurane suppresses the malignant progression of breast cancer via the hsa_circ_0000129/miR-578/EPSTI1 axis.	hsa_circ_0000129	circ_0000129	hsa_circ_TMOD4	TMOD4	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0000129 is up-regulated in breast cancer tissues/cells and acts as a ceRNA that sponges miR-578 to increase EPSTI1 expression. Functionally, circ_0000129 counteracts sevoflurane¡¯s anti-tumor effects by promoting proliferation, migration and invasion and reducing apoptosis, and it partially reverses sevoflurane-suppressed tumor growth in xenografts."	0.7856
37537636	Journal of ovarian research	2023	Integrated bioinformatics analysis elucidates granulosa cell whole-transcriptome landscape of PCOS in China.	hsa_circ_0020555				Polycystic ovary syndrome / PCOS	MONDO:0008487	polycystic ovary syndrome	down-regulated	RT-qPCR; Microarray	"hsa-circ-0020555 is downregulated in granulosa cells from PCOS patients and is included in a ceRNA network as a predicted regulator (sponge) of hsa-miR-205-5p, which targets hub genes such as MVD and PNPLA3."	0.4032
37537636	Journal of ovarian research	2023	Integrated bioinformatics analysis elucidates granulosa cell whole-transcriptome landscape of PCOS in China.	hsa_circ_0027651				Polycystic ovary syndrome / PCOS	MONDO:0008487	polycystic ovary syndrome	down-regulated	RT-qPCR; Microarray	"hsa-circ-0027651 is downregulated in granulosa cells from PCOS patients and is included in a ceRNA network as a predicted regulator of hsa-miR-205-5p, which regulates hub genes including MVD and PNPLA3."	0.4032
37537636	Journal of ovarian research	2023	Integrated bioinformatics analysis elucidates granulosa cell whole-transcriptome landscape of PCOS in China.	hsa_circ_0086809				Polycystic ovary syndrome / PCOS	MONDO:0008487	polycystic ovary syndrome	down-regulated	RT-qPCR; Microarray	"hsa-circ-0086809 is downregulated in granulosa cells from PCOS patients and is part of a ceRNA network predicted to regulate hsa-miR-205-5p, which controls expression of hub genes such as MVD and PNPLA3."	0.4032
37537636	Journal of ovarian research	2023	Integrated bioinformatics analysis elucidates granulosa cell whole-transcriptome landscape of PCOS in China.	hsa_circ_0118448				Polycystic ovary syndrome / PCOS	MONDO:0008487	polycystic ovary syndrome	down-regulated	RT-qPCR; Microarray	"hsa-circ-0118448 is downregulated in granulosa cells from PCOS patients and is proposed within the study¡¯s ceRNA network to regulate hsa-miR-205-5p, linking it to downstream hub genes including MVD and PNPLA3."	0.4032
37537733	Clinical and translational medicine	2023	CircGNB1 drives osteoarthritis pathogenesis by inducing oxidative stress in chondrocytes.	hsa_circ_0008702	circGNB1	hsa_circ_GNB1	GNB1	osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; RNA-seq	"circGNB1 is up-regulated in osteoarthritic/aged cartilage and stressed chondrocytes and promotes OA phenotypes. It acts as a cytoplasmic ceRNA that sponges miR-152-3p to increase RNF219, which stabilizes CAV1 by reducing its ubiquitination (K47), thereby inhibiting IL-10 signaling (IL-10R/JAK/STAT3) and enhancing oxidative stress and cartilage catabolism."	0.8853
37539185	Heliyon	2023	Circular RNA circSLC7A11 contributes to progression and stemness of laryngeal squamous cell carcinoma via sponging miR-877-5p from LASP1.	hsa_circ_0070975	circSLC7A11	hsa_circ_SLC7A11	SLC7A11	laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR	"circSLC7A11 is up-regulated in LSCC and its high expression correlates with advanced TNM stage and poorer overall survival. Functionally, circSLC7A11 promotes LSCC malignant phenotypes (proliferation, migration/invasion, stemness) and suppresses apoptosis by sponging miR-877-5p to increase LASP1."	0.7754
37540226	Aging	2023	hsa_circ_0010889 downregulation inhibits malignant glioma progression by modulating the miR-590-5p/SATB1 axis.	hsa_circ_0010889	circ-PITHD1	hsa_circ_PITHD1	PITHD1	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; ISH; RNA-seq	"hsa_circ_0010889 is up-regulated in glioma tissues and cell lines and promotes malignant behaviors. Its knockdown suppresses glioma proliferation, migration/invasion and in vivo tumor growth/metastasis by sponging miR-590-5p to increase SATB1 (miR-590-5p/SATB1 axis), and is suggested as a diagnostic marker/therapeutic target."	0.6975
37543909	Archives of Iranian medicine	2022	Altered Expression of hsa_circ_0001445 and hsa_circ_0020397 in Breast Cancer Representing Associations with BMI and Reproductive Factors.	hsa_circ_0001445	circ-SMARCA5 / circSMARCA5	hsa_circ_SMARCA5	SMARCA5	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	hsa_circ_0001445 is down-regulated in breast cancer tissues versus adjacent normal tissues. The study suggests it may act as a tumor-suppressive circRNA by participating in predicted ceRNA networks (miRNA sponging) that could influence multiple cancer-relevant mRNAs.	0.348
37543909	Archives of Iranian medicine	2022	Altered Expression of hsa_circ_0001445 and hsa_circ_0020397 in Breast Cancer Representing Associations with BMI and Reproductive Factors.	hsa_circ_0020397		hsa_circ_DOCK1	DOCK1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	hsa_circ_0020397 is up-regulated in breast cancer tissues versus adjacent normal tissues and is associated with lack of vitamin D consumption. The study proposes that it may function through predicted circRNA/miRNA/mRNA ceRNA networks involving miRNAs such as hsa-mir-638 and hsa-mir-665 and target mRNAs including PTEN and TP53.	0.348
37549641	Cancer science	2023	Nucleus-localized circSLC39A5 suppresses hepatocellular carcinoma development by binding to STAT1 to regulate TDG transcription.	hsa_circ_0026920	circSLC39A5	hsa_circ_SLC39A5	SLC39A5	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"circSLC39A5 is down-regulated in HCC tissues and plasma and shows diagnostic potential in plasma. Functionally, it suppresses HCC malignant phenotypes (proliferation, migration, invasion) and promotes apoptosis, including reduced tumor growth in xenografts. Mechanistically, nucleus-localized circSLC39A5 binds STAT1 to increase STAT1 stability/expression, enhancing STAT1-driven TDG transcription and reducing PCNA to inhibit proliferation."	0.8988
37550899	Brain and behavior	2023	DHT inhibits REDOX damage and neuroinflammation to reduce PND occurrence in aged mice via mmu_circ_0001442/miR-125a-3p/NUFIP2 axis.	mmu_circ_0001442				Perioperative neurocognitive disorder / PND	MONDO:0002602	central nervous system disorder	dysregulated	RT-qPCR; RNA-seq	"In an abdominal-surgery PND mouse model, mmu_circ_0001442 is identified as the key circRNA responsive to DHT treatment. It directly binds miR-125a-3p and regulates NUFIP2, contributing to reduced neuroinflammation (e.g., IL-6, TNF-alpha) and REDOX damage; knockdown of mmu_circ_0001442 partially weakens DHT¡¯s protective effects in vitro."	0.6435
37553672	Diagnostic pathology	2023	Circ_0001715 accelerated lung adenocarcinoma process by the miR-1322/CANT1 axis.	hsa_circ_0001715	circ_0001715	hsa_circ_LIMK1	LIMK1	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"circ_0001715 is up-regulated in LUAD tissues and cell lines and promotes malignant phenotypes (proliferation, migration, sphere formation, and angiogenesis-related tube formation) while inhibiting apoptosis. Mechanistically, it functions as a ceRNA by sponging miR-1322 to increase CANT1, and its knockdown suppresses xenograft tumor growth."	0.8006
37554147	"Open medicine (Warsaw, Poland)"	2023	Hsa_circ_0028007 regulates the progression of nasopharyngeal carcinoma through the miR-1179/SQLE axis.	hsa_circ_0028007	circ_0028007			nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"circ_0028007 is up-regulated in nasopharyngeal carcinoma tissues and cells and promotes malignant phenotypes. Mechanistically, it sponges miR-1179 to increase SQLE expression, thereby enhancing proliferation and glycolysis and reducing apoptosis; circ_0028007 knockdown suppresses xenograft tumor growth."	0.7412
37554539	Translational neuroscience	2023	Knockdown of circEXOC6 inhibits cell progression and glycolysis by sponging miR-433-3p and mediating FZD6 in glioma.	hsa_circ_0019170	CircEXOC6	hsa_circ_EXOC6	EXOC6	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circEXOC6 is up-regulated in glioma tissues and cell lines. circEXOC6 promotes malignant phenotypes (proliferation, migration/invasion, angiogenesis) and glycolysis while inhibiting apoptosis, mainly by sponging miR-433-3p to increase FZD6; circEXOC6 knockdown suppresses xenograft tumor growth."	0.8497
37554544	FASEB bioAdvances	2023	Comprehensive analysis of circRNAs for N7-methylguanosine methylation modification in human oral squamous cell carcinoma.	hsa_circ_0111121		hsa_circ_KIFAP3	KIFAP3	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RNA-seq	"hsa_circ_0111121 (from KIFAP3) is down-regulated in OSCC and shows hypermethylated m7G peaks. The study predicts a circRNA_miRNA_mRNA ceRNA network for this circRNA, but does not experimentally validate specific miRNA/mRNA targets or functional phenotypes."	0.329
37554544	FASEB bioAdvances	2023	Comprehensive analysis of circRNAs for N7-methylguanosine methylation modification in human oral squamous cell carcinoma.	hsa_circ_0084188		hsa_circ_SPIDR	SPIDR	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RNA-seq	"hsa_circ_0084188 (chr8:48192450-48206619; host gene SPIDR) is up-regulated in OSCC. It is predicted to act as a ceRNA by binding hsa-miR-1200 and thereby increasing UHRF1BP1 expression, based on network prediction rather than experimental validation."	0.1768
37554968	NAR cancer	2023	Circular stable intronic RNAs possess distinct biological features and are deregulated in bladder cancer.			hsa_circ_HNRNPK	HNRNPK	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	dysregulated	RNA-seq	"sisHNRNPK is differentially expressed across NMIBC prognostic risk classes (higher in class 1 than class 2/3) and its higher expression is associated with better progression-free survival, suggesting potential prognostic value in early-stage bladder cancer."	0.6513
37554968	NAR cancer	2023	Circular stable intronic RNAs possess distinct biological features and are deregulated in bladder cancer.			hsa_circ_WDR13	WDR13	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	dysregulated	RNA-seq	"sisWDR13 is differentially expressed across NMIBC prognostic risk classes (higher in class 1 than class 2/3) and its higher expression is associated with better progression-free survival, indicating potential prognostic relevance in early-stage bladder cancer."	0.6513
37556099	Journal of cellular and molecular medicine	2024	SP2-induced circPUM1 modulates chemoresistance and nature killer cell toxicity in oral squamous cell carcinoma.	hsa_circ_0000043	circPUM1	hsa_circ_PUM1	PUM1	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	unknown	RT-qPCR	"In OSCC cell lines, circPUM1 promotes cisplatin (CDDP) chemoresistance and reduces susceptibility to NK cell-mediated killing. Mechanistically, SP2 transcriptionally upregulates circPUM1, which sponges miR-770-5p to de-repress NAP1L1, forming an SP2/circPUM1/miR-770-5p/NAP1L1 axis."	0.7366
37559140	Journal of orthopaedic surgery and research	2023	CircECE1 promotes osteosarcoma progression through regulating RAB3D by sponging miR-588.	hsa_circ_0002402	circECE1 / circRNA endothelin converting enzyme 1	hsa_circ_ECE1	ECE1	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circECE1 (hsa_circ_0002402), derived from ECE1, is up-regulated in osteosarcoma tissues and cells and promotes malignant phenotypes (proliferation, migration/invasion) while inhibiting apoptosis. Mechanistically, circECE1 sponges miR-588 to de-repress RAB3D, forming a circECE1/miR-588/RAB3D ceRNA axis; circECE1 knockdown suppresses xenograft tumor growth."	0.8172
37563869	Journal of cellular and molecular medicine	2023	CircLDLRAD3 inhibits Oral squamous cell carcinoma progression by regulating miR-558/Smad4/TGF-beta.	hsa_circ_0006988	circLDLRAD3	hsa_circ_LDLRAD3	LDLRAD3	Oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR; ISH	"circLDLRAD3 is downregulated in OSCC and functions as a tumor suppressor. It mainly localizes to the cytoplasm and sponges miR-558 to increase Smad4, thereby inhibiting TGF-beta_driven EMT and suppressing proliferation, migration, invasion, and metastasis."	0.8684
37564195	International journal of biological sciences	2023	Androgen receptor suppresses lung cancer invasion and increases cisplatin response via decreasing TPD52 expression.	hsa_circ_0025583	circ-SLCO1B7	hsa_circ_SLCO1B7	SLCO1B7	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circ-SLCO1B7 is up-regulated in lung cancer tissues and promotes lung cancer cell invasion while reducing cisplatin response. Mechanistically, it acts as a ceRNA that sponges miR-139-5p to increase TPD52, and its transcription is repressed by AR via binding the SLCO1B7 promoter (ARE1/2, with NcoR1), forming an AR/circ-SLCO1B7/miR-139-5p/TPD52 axis validated in cells, clinical specimens, and an in vivo xenograft model."	0.8494
37564198	International journal of biological sciences	2023	Intergenic CircRNA Circ_0007379 Inhibits Colorectal Cancer Progression by Modulating miR-320a Biogenesis in a KSRP-Dependent Manner.	hsa_circ_0007379	circ_0007379 / circ7379	hsa_circ_intergenic		colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	"circ_0007379 (circ7379; hsa_circ_0007379) is down-regulated in colorectal cancer and functions as a tumor suppressor. It binds KSRP and serves as a scaffold to promote pri-/pre-miR-320a processing, increasing mature miR-320a and thereby repressing RUNX1 to inhibit CRC proliferation and metastasis, including in PDO/PDX and xenograft models."	0.898
37566064	Cells	2023	The Role of circTmeff-1 in Morphine Addiction Memory of Mice.	mmu_circ_0011663	CircTmeff-1	mmu_circ_Tmeff-1	Tmeff-1	morphine addiction memory	MONDO:0005530	opiate dependence	up-regulated	RT-qPCR; ISH; RNA-seq	"In a mouse morphine CPP addiction-memory model, circTmeff-1 is up-regulated in the NAc core (not shell) during memory expression and its knockdown in NAc core or shell reduces morphine CPP scores. Mechanistically, it is proposed to act as a miRNA sponge and is associated with MAPK and AMPK pathway regulation based on GO/KEGG analyses."	0.6054
37575469	International journal of genomics	2023	circ_0008285 Regulates Glioma Progression via the miR-384/HMGB1 Axis.	hsa_circ_0008285	circ_0008285	hsa_circ_CDYL		glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; Microarray	circ_0008285 is up-regulated in glioma tissues/cell lines and its high expression is associated with worse prognosis. It promotes glioma cell proliferation and cell-cycle progression and inhibits apoptosis by acting as a ceRNA that sponges miR-384 to increase HMGB1 expression.	0.7756
37577235	Journal of clinical and translational hepatology	2023	"Exosome-transported circHDAC1_004 Promotes Proliferation, Migration, and Angiogenesis of Hepatocellular Carcinoma by the miR-361-3p/NACC1 Axis."	hsa_circ_0005339	circHDAC1_004 / circ_0005339	hsa_circ_HDAC1	HDAC1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circHDAC1_004 is up-regulated in HCC and its high expression indicates poorer overall survival. It mainly localizes to the cytoplasm, is transported via exosomes, and promotes HCC proliferation, migration/invasion, stemness, EMT, metastasis, and angiogenesis by sponging miR-361-3p to upregulate NACC1."	0.8871
37579846	Virus research	2023	The neuropathological mechanism of EV-A71 infection attributes to inflammatory pryoptosis and viral replication via activating the hsa_circ_0045431/ hsa_miR_584/NLRP3 regulatory axis.	hsa_circ_0045431				enterovirus 71 infection / EV71 infection	MONDO:0005747	enterovirus infectious disease	up-regulated	RT-qPCR; RNA-seq	"In EV-A71-infected SH-SY5Y cells, hsa_circ_0045431 is up-regulated and promotes NLRP3-dependent inflammatory pyroptosis and inflammatory cytokine production. Mechanistically, it sponges hsa_miR_584, relieving repression on NLRP3, and this axis also enhances EV-A71 viral replication."	0.7204
37582769	Cell death & disease	2023	Methionine orchestrates the metabolism vulnerability in cisplatin resistant bladder cancer microenvironment.	hsa_circ_0001449	circARHGAP10 / circOE2	hsa_circ_ARHGAP10	ARHGAP10	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"circARHGAP10 is down-regulated in bladder cancer and cisplatin-resistant BCa cells. It binds MAT2A and TRIM25 and functions as an RNA scaffold to enhance TRIM25-dependent (K48-linked) ubiquitination and proteasomal degradation of MAT2A, thereby suppressing methionine metabolism-associated stemness and reducing cisplatin resistance; higher circARHGAP10 predicts better prognosis and lower recurrence."	0.8961
37582769	Cell death & disease	2023	Methionine orchestrates the metabolism vulnerability in cisplatin resistant bladder cancer microenvironment.	mmu_circ_0014984	circArhgap10	mmu_circ_Arhgap10	Arhgap10	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	unknown	RT-qPCR	"In mouse cisplatin-resistant bladder cancer cells (MB49-CR), circArhgap10 (mmu_circ_0014984) shows conserved function with the human ortholog, promoting TRIM25-mediated ubiquitination of MAT2A and reducing MAT2A-linked stemness and cisplatin-resistant viability when overexpressed."	0.5798
37587156	Scientific reports	2023	"Expression status of circ-SMARCA5, circ-NOL10, circ-LDLRAD3, and circ-RHOT1 in patients with colorectal cancer."	hsa_circ_0000977	circ-NOL10	hsa_circ_NOL10	NOL10	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"In CRC patient blood, circ-NOL10 is significantly up-regulated versus healthy controls and shows diagnostic value. The paper discusses that circ-NOL10 may inhibit CRC cell proliferation and migration via a ceRNA mechanism involving miR-135a/b-5p and KLF9."	0.4187
37587156	Scientific reports	2023	"Expression status of circ-SMARCA5, circ-NOL10, circ-LDLRAD3, and circ-RHOT1 in patients with colorectal cancer."	hsa_circ_0006988	circ-LDLRAD3	hsa_circ_LDLRAD3	LDLRAD3	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ-LDLRAD3 is significantly up-regulated in CRC patient blood compared with healthy controls and shows diagnostic value. The discussion suggests circ-LDLRAD3 may regulate CRC progression through ceRNA interactions with miR-491-5P and miR-137 family members, affecting targets such as MAP3K3, IGF2 and SLC1A5."	0.4187
37587156	Scientific reports	2023	"Expression status of circ-SMARCA5, circ-NOL10, circ-LDLRAD3, and circ-RHOT1 in patients with colorectal cancer."		circ-RHOT1 / circ-RHOT-1	hsa_circ_RHOT1	RHOT1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ-RHOT1 is significantly up-regulated in CRC patient blood compared with healthy controls and has diagnostic value. The discussion proposes that circ-RHOT1 may promote CRC proliferation and invasion by sponging miR-125a, miR-326 and miR-3666, thereby influencing downstream targets such as PDK2 and SATB2-related pathways."	0.4187
37587207	Scientific reports	2023	Hedyotis diffusa-Sculellaria barbata (HD-SB) suppresses the progression of colorectal cancer cells via the hsa_circ_0039933/hsa-miR-204-5p/wnt11 axis.	hsa_circ_0039933				colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"In CRC cell lines, hsa_circ_0039933 acts as a pro-tumor circRNA by sponging hsa-miR-204-5p, thereby increasing wnt11 expression and activating Wnt/beta-catenin signaling. Knockdown suppresses proliferation, migration and invasion and increases apoptosis, while overexpression shows the opposite effects; HD_SB treatment downregulates hsa_circ_0039933 in SW620 cells."	0.7198
37587471	Journal of translational medicine	2023	Platelet-derived circRNAs signature in patients with gastroenteropancreatic neuroendocrine tumors.			hsa_circ_USP32	USP32	gastroenteropancreatic neuroendocrine tumors / GEP-NETs	MONDO:0024503	digestive system neuroendocrine neoplasm	down-regulated	RNA-seq	"In tumor-educated platelets from patients with GEP-NETs, USP32 circRNA is significantly down-regulated versus controls based on RNA-seq/edgeR. It is proposed as part of a platelet-derived circRNA signature with potential diagnostic and early treatment-response predictive value, but lacks RT-qPCR validation in this study."	0.1768
37587471	Journal of translational medicine	2023	Platelet-derived circRNAs signature in patients with gastroenteropancreatic neuroendocrine tumors.			hsa_circ_EXOC5	EXOC5	gastroenteropancreatic neuroendocrine tumors / GEP-NETs	MONDO:0024503	digestive system neuroendocrine neoplasm	down-regulated	RNA-seq	"EXOC5 circRNA is one of five platelet-derived circRNAs significantly down-regulated in GEP-NET patients versus controls in RNA-seq analysis. It is proposed as part of a diagnostic/predictive liquid-biopsy signature, but was not validated by RT-qPCR in this study."	0.1768
37587471	Journal of translational medicine	2023	Platelet-derived circRNAs signature in patients with gastroenteropancreatic neuroendocrine tumors.			hsa_circ_IQGAP2	IQGAP2	gastroenteropancreatic neuroendocrine tumors / GEP-NETs	MONDO:0024503	digestive system neuroendocrine neoplasm	down-regulated	RNA-seq	"IQGAP2 circRNA is significantly down-regulated in platelet RNA from GEP-NET patients compared with controls based on RNA-seq differential expression. It is included in a proposed platelet-derived circRNA diagnostic/predictive signature, without RT-qPCR confirmation in this work."	0.1768
37587471	Journal of translational medicine	2023	Platelet-derived circRNAs signature in patients with gastroenteropancreatic neuroendocrine tumors.			hsa_circ_DAAM1	DAAM1	gastroenteropancreatic neuroendocrine tumors / GEP-NETs	MONDO:0024503	digestive system neuroendocrine neoplasm	down-regulated	RNA-seq	"DAAM1 circRNA is significantly down-regulated in tumor-educated platelets from GEP-NET patients versus controls based on RNA-seq. It is proposed as a candidate platelet-derived liquid-biopsy biomarker for diagnosis and early treatment-response prediction, pending RT-qPCR validation."	0.1768
37587471	Journal of translational medicine	2023	Platelet-derived circRNAs signature in patients with gastroenteropancreatic neuroendocrine tumors.			hsa_circ_TMCO3	TMCO3	gastroenteropancreatic neuroendocrine tumors / GEP-NETs	MONDO:0024503	digestive system neuroendocrine neoplasm	down-regulated	RNA-seq	"TMCO3 circRNA is one of five circRNAs found significantly down-regulated in platelet RNA from GEP-NET patients relative to controls using RNA-seq differential expression. It is proposed as a candidate platelet-derived biomarker for GEP-NET detection and early response prediction, without RT-qPCR validation in the present study."	0.1768
37592296	Biology direct	2023	Circular RNA hsa_circ_0067842 facilitates tumor metastasis and immune escape in breast cancer through HuR/CMTM6/PD-L1 axis.	hsa_circ_0067842		hsa_circ_SMC4	SMC4	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; ISH; Microarray	"hsa_circ_0067842 is upregulated in breast cancer and is associated with worse survival. It promotes migration/invasion and immune escape by binding the RBP HuR, facilitating HuR cytoplasmic translocation to stabilize CMTM6 mRNA, which in turn reduces PD-L1 ubiquitination and inhibits PD-L1 degradation."	0.8818
37593150	Frontiers in cardiovascular medicine	2023	Cfa-circ002203 was upregulated in rapidly paced atria of dogs and involved in the mechanisms of atrial fibrosis.		cfa-circ002203 / circRNA_002203 / circ002203			atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	up-regulated	RT-qPCR; RNA-seq	"In a rapid atrial pacing dog model of AF-related atrial fibrosis and an Ang II-induced canine atrial fibroblast fibrosis model, cfa-circ002203 is upregulated. Functionally, it promotes fibroblast proliferation, migration, inflammatory cytokine secretion and fibrotic marker expression, while inhibiting apoptosis."	0.6287
37601820	Cancer management and research	2023	The Circular RNA circFGFR4 Facilitates Resistance to Anti-PD-1 of Triple-Negative Breast Cancer by Targeting the miR-185-5p/CXCR4 Axis.	hsa_circ_0075147	circFGFR4 / circular fibroblast growth factor receptor 4 RNA	hsa_circ_FGFR4	FGFR4	triple negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"circFGFR4 (hsa_circ_0075147) is upregulated in TNBC and promotes immune evasion and anti-PD-1 resistance. It functions as a ceRNA by sponging miR-185-5p, thereby upregulating CXCR4 and reducing CD8+ T-cell infiltration; high circFGFR4 is associated with worse prognosis and poorer PFS under pembrolizumab."	0.7874
37603540	PLoS pathogens	2023	The circRNA circVAMP3 restricts influenza A virus replication by interfering with NP and NS1 proteins.	hsa_circ_0006354	circVAMP3	hsa_circ_VAMP3	VAMP3	influenza A virus infection / IAV infection	MONDO:0005812	influenza	up-regulated	RT-qPCR; RNA-seq	"circVAMP3 (hsa_circ_0006354), derived from VAMP3 exons 3_4, is induced by IAV infection and IFN-beta and is mainly cytoplasmic. It restricts IAV replication in vitro and in mouse lungs in vivo by directly binding viral NP and NS1, weakening NP_PB1/PB2/vRNA interactions to impair vRNP activity and relieving NS1-mediated inhibition of RIG-I/TRIM25 to restore IFN-beta signaling."	0.8439
37603701	Annals of medicine	2023	Reveal the potential molecular mechanism of circRNA regulating immune-related mRNA through sponge miRNA in the occurrence and immune regulation of papillary thyroid cancer.	hsa_circ_0082182				papillary thyroid cancer / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0082182 is up-regulated in PTC tissues and promotes malignant phenotypes of PTC cells. Functional assays in TPC-1 cells show that hsa_circ_0082182 knockdown suppresses proliferation, migration and invasion, and reporter assays support a ceRNA interaction with hsa-miR-18b-5p targeting FGF1."	0.6537
37603701	Annals of medicine	2023	Reveal the potential molecular mechanism of circRNA regulating immune-related mRNA through sponge miRNA in the occurrence and immune regulation of papillary thyroid cancer.	hsa_circ_0016404				papillary thyroid cancer / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0016404 is up-regulated in PTC tissues (qRT-PCR validation) and is included in a predicted immune-related ceRNA axis with hsa-miR-1275 and downstream targets including FGF1, CTSB and IL13RA1."	0.4032
37603701	Annals of medicine	2023	Reveal the potential molecular mechanism of circRNA regulating immune-related mRNA through sponge miRNA in the occurrence and immune regulation of papillary thyroid cancer.	hsa_circ_0070100				papillary thyroid cancer / PTC	MONDO:0005075	thyroid gland papillary carcinoma	dysregulated	Microarray	"hsa_circ_0070100 was identified by microarray-based differential analysis as abnormally expressed in PTC and incorporated into a predicted ceRNA axis with hsa-miR-27a-3p/hsa-miR-27b-3p and TGFBR3, potentially affecting PTC progression and migration."	0.1768
37603701	Annals of medicine	2023	Reveal the potential molecular mechanism of circRNA regulating immune-related mRNA through sponge miRNA in the occurrence and immune regulation of papillary thyroid cancer.	hsa_circ_0060055				papillary thyroid cancer / PTC	MONDO:0005075	thyroid gland papillary carcinoma	unknown	Microarray	hsa_circ_0060055 was identified in a PTC ceRNA sub-network as a putative regulator of CXCL14 via sponging hsa-miR-150-3p. Its functional impact in PTC was not experimentally validated in this paper.	0.1768
37603701	Annals of medicine	2023	Reveal the potential molecular mechanism of circRNA regulating immune-related mRNA through sponge miRNA in the occurrence and immune regulation of papillary thyroid cancer.	hsa_circ_0038718				papillary thyroid cancer / PTC	MONDO:0005075	thyroid gland papillary carcinoma	unknown	Microarray	hsa_circ_0038718 was included in the identified PTC ceRNA sub-network as a putative sponge of hsa-miR-150-3p affecting CXCL14. This paper did not experimentally validate its expression direction or function in PTC.	0.1768
37603701	Annals of medicine	2023	Reveal the potential molecular mechanism of circRNA regulating immune-related mRNA through sponge miRNA in the occurrence and immune regulation of papillary thyroid cancer.	hsa_circ_0030427				papillary thyroid cancer / PTC	MONDO:0005075	thyroid gland papillary carcinoma	unknown	Microarray	"hsa_circ_0030427 was identified computationally in PTC as part of predicted ceRNA axes involving hsa-miR-22-3p/BMP7 and hsa-miR-125a-5p/LIFR, potentially influencing proliferation, invasion and apoptosis, but without direct experimental validation in this study."	0.1768
37603701	Annals of medicine	2023	Reveal the potential molecular mechanism of circRNA regulating immune-related mRNA through sponge miRNA in the occurrence and immune regulation of papillary thyroid cancer.	hsa_circ_0002917	circ TBC1D4	hsa_circ_TBC1D4	TBC1D4	papillary thyroid cancer / PTC	MONDO:0005075	thyroid gland papillary carcinoma	unknown	Microarray	"hsa_circ_0002917 (circ TBC1D4) was identified bioinformatically in PTC as part of predicted ceRNA axes with hsa-miR-22-3p/BMP7 and hsa-miR-125a-5p/LIFR, but without direct experimental validation in this paper."	0.1768
37606201	Cancer biology & therapy	2023	CircSETD2 inhibits YAP1 by interaction with HuR during breast cancer progression.	hsa_circ_0065173	circSETD2	hsa_circ_SETD2	SETD2	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	"circSETD2 is down-regulated in breast cancer tissues/cells and acts as a tumor suppressor by inhibiting proliferation, migration, invasion and EMT. It binds the RBP HuR and competitively disrupts HuR-mediated stabilization of YAP1 mRNA, reducing YAP1 and downstream targets (e.g., CTGF, myc, SOX2, Slug), thereby suppressing breast cancer progression."	0.8095
37608076	Molecular biotechnology	2024	CircRNA-CIRH1A Promotes the Development of Osteosarcoma by Regulating PI3K/AKT and JAK2/STAT3 Signaling Pathways.	hsa_circ_0007018	circRNA-CIRH1A / circ_0007018	hsa_circ_CIRH1A	CIRH1A	osteosarcoma / OS / Osteogenic sarcoma	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circRNA-CIRH1A (circ_0007018) is up-regulated in osteosarcoma tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion) while inhibiting apoptosis, including enhanced tumorigenesis in a U2OS xenograft model. Mechanistically, it acts predominantly in the cytoplasm as a sponge for miR-1276, leading to activation of PI3K/AKT and JAK2/STAT3 signaling. High circRNA-CIRH1A expression is associated with advanced clinicopathological features and poorer overall survival."	0.8232
37608665	Combinatorial chemistry & high throughput screening	2024	Analysis of Potential Circular RNAs in Regulating Imatinib Resistance of Gastrointestinal Stromal Tumor.		circRNA_06551			Gastrointestinal stromal tumor / GIST	MONDO:0011719	gastrointestinal stromal tumor	down-regulated	RNA-seq	"circRNA_06551 is down-regulated in imatinib secondary resistance GIST versus primary GIST and is predicted to participate in an HIF-1 pathway-related ceRNA network. The proposed axis includes circRNA_06551 sponging hsa-miR-1915-3p to affect PFKFB3 expression, potentially contributing to drug resistance."	0.1768
37608665	Combinatorial chemistry & high throughput screening	2024	Analysis of Potential Circular RNAs in Regulating Imatinib Resistance of Gastrointestinal Stromal Tumor.		circRNA_14668			Gastrointestinal stromal tumor / GIST	MONDO:0011719	gastrointestinal stromal tumor	down-regulated	RNA-seq	"circRNA_14668 is down-regulated in imatinib secondary resistance GIST versus primary GIST and is predicted to act in an HIF-1-related ceRNA network. A proposed axis is circRNA_14668_hsa-miR-8485_VEGFA, potentially linking it to hypoxia/angiogenesis-associated drug resistance biology."	0.1768
37608665	Combinatorial chemistry & high throughput screening	2024	Analysis of Potential Circular RNAs in Regulating Imatinib Resistance of Gastrointestinal Stromal Tumor.		circRNA_04497	hsa_circ_DPP10	DPP10	Gastrointestinal stromal tumor / GIST	MONDO:0011719	gastrointestinal stromal tumor	down-regulated	RNA-seq	circRNA_04497 (host gene DPP10) is down-regulated in imatinib secondary resistance GIST versus primary GIST. It is predicted to regulate HIF-1-pathway-related drug resistance through ceRNA axes including hsa-miR-6808-5p/PFKFB3 and hsa-miR-8485/VEGFA.	0.1768
37608665	Combinatorial chemistry & high throughput screening	2024	Analysis of Potential Circular RNAs in Regulating Imatinib Resistance of Gastrointestinal Stromal Tumor.		circRNA_08683			Gastrointestinal stromal tumor / GIST	MONDO:0011719	gastrointestinal stromal tumor	down-regulated	RNA-seq	circRNA_08683 is down-regulated in imatinib secondary resistance GIST versus primary GIST and is predicted to be part of an HIF-1-related circRNA-miRNA-mRNA network. The proposed axis is circRNA_08683_hsa-miR-6728-5p_ENO2.	0.1768
37608665	Combinatorial chemistry & high throughput screening	2024	Analysis of Potential Circular RNAs in Regulating Imatinib Resistance of Gastrointestinal Stromal Tumor.		circRNA_09923			Gastrointestinal stromal tumor / GIST	MONDO:0011719	gastrointestinal stromal tumor	down-regulated	RNA-seq	"circRNA_09923 is down-regulated in imatinib secondary resistance GIST versus primary GIST and is predicted to participate in an HIF-1-related ceRNA network. Proposed axes include hsa-miR-4755-3p/PFKFB3 and hsa-miR-3155p(or hsa-miR-3155a)/HK2, implicating metabolic regulation in drug resistance."	0.1768
37608665	Combinatorial chemistry & high throughput screening	2024	Analysis of Potential Circular RNAs in Regulating Imatinib Resistance of Gastrointestinal Stromal Tumor.		circRNA_23636			Gastrointestinal stromal tumor / GIST	MONDO:0011719	gastrointestinal stromal tumor	up-regulated	RNA-seq	"circRNA_23636 is up-regulated in imatinib secondary resistance GIST versus primary GIST and is predicted to be involved in an HIF-1-pathway ceRNA network. A proposed axis is circRNA_23636_has-miR-6077_SLC2A1, suggesting a link to hypoxia/metabolic regulation in drug resistance."	0.1768
37608665	Combinatorial chemistry & high throughput screening	2024	Analysis of Potential Circular RNAs in Regulating Imatinib Resistance of Gastrointestinal Stromal Tumor.		circRNA_15734			Gastrointestinal stromal tumor / GIST	MONDO:0011719	gastrointestinal stromal tumor	up-regulated	RNA-seq	circRNA_15734 is up-regulated in imatinib secondary resistance GIST versus primary GIST and is predicted to contribute to an HIF-1-related ceRNA network. Proposed downstream axes include hsa-miR-6893-5p/PFKFB3 and hsa-miR-8485/VEGFA.	0.1768
37616050	Aging	2023	The novel angiogenesis regulator circFAM169A promotes the metastasis of colorectal cancer through the angiopoietin-2 signaling axis.	hsa_circ_0007158	circFAM169A / circ0007158	hsa_circ_FAM169A	FAM169A	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq; Microarray	"circFAM169A is up-regulated in CRC (including liver-metastasized CRC) and promotes angiogenesis and metastatic behaviors (migration/invasion) in vitro and in nude-mouse metastasis models. Mechanistically, it functions as a ceRNA by sponging miR-518a-5p to upregulate ANGPT2, impacting Tie2 phosphorylation and increasing p-FAK/p-AKT signaling to enhance angiogenesis."	0.8668
37616056	Aging	2023	Integrative analysis links autophagy to intrauterine adhesion and establishes autophagy-related circRNA-miRNA-mRNA regulatory network.	hsa_circ_0047959				Intrauterine adhesion / IUA / Asherman's syndrome	MONDO:0015299	Asherman syndrome	up-regulated	RT-qPCR	"hsa-circ-0047959 is a hub autophagy-related circRNA that is upregulated in IUA endometrial tissues. In TGF-beta_treated ESCs, silencing this hub circRNA (tested as part of hub ARCs) enhances autophagy markers (Beclin1, LC3B) and reduces myofibroblast transformation and collagen deposition, implicating it in autophagy-linked fibrosis in IUA."	0.5804
37616056	Aging	2023	Integrative analysis links autophagy to intrauterine adhesion and establishes autophagy-related circRNA-miRNA-mRNA regulatory network.	hsa_circ_0032438				Intrauterine adhesion / IUA / Asherman's syndrome	MONDO:0015299	Asherman syndrome	up-regulated	RT-qPCR	hsa-circ-0032438 is a hub autophagy-related circRNA upregulated in IUA endometrial tissue. It is proposed to regulate (sponge) hsa-miR-449c-5p and hsa-miR-449a within a circRNA_miRNA_mRNA network; silencing hub ARCs in ESCs increases autophagy and reduces myofibroblast transformation and collagen deposition under TGF-beta stimulation.	0.5804
37616056	Aging	2023	Integrative analysis links autophagy to intrauterine adhesion and establishes autophagy-related circRNA-miRNA-mRNA regulatory network.	hsa_circ_0047301				Intrauterine adhesion / IUA / Asherman's syndrome	MONDO:0015299	Asherman syndrome	up-regulated	RT-qPCR	"hsa-circ-0047301 is a hub autophagy-related circRNA upregulated in IUA tissues and is proposed to regulate hsa-miR-320c as a miRNA sponge within a circRNA_miRNA_mRNA network. Silencing hub ARCs in ESCs under TGF-beta stimulation increases autophagy and decreases myofibroblast transformation and collagen deposition, supporting a pro-fibrotic role linked to impaired autophagy in IUA."	0.5804
37622004	iScience	2023	circAGTPBP1 promotes the progression of papillary thyroid cancer through the notch pathway via the miR-34a-5p/notch1 axis.	hsa_circ_0087391	circAGTPBP1	hsa_circ_AGTPBP1	AGTPBP1	papillary thyroid cancer / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; RNA-seq	"circAGTPBP1 is upregulated in papillary thyroid cancer and promotes proliferation, migration, invasion, EMT, metastasis, and in vivo tumor growth. It functions as a ceRNA that sponges miR-34a-5p to de-repress NOTCH1, thereby activating Notch signaling."	0.852
37626035	Cell death & disease	2023	EIF4A3-mediated circ_0042881 activates the RAS pathway via miR-217/SOS1 axis to facilitate breast cancer progression.	hsa_circ_0042881	circ_0042881 / circNF1	hsa_circ_NF1	NF1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0042881 (circNF1) is upregulated in breast cancer tissues and plasma and promotes proliferation, migration, invasion, tumor growth, and lung metastasis. It mainly localizes to the cytoplasm and acts as a ceRNA by sponging miR-217 to upregulate SOS1, thereby activating RAS and downstream MEK/ERK and PI3K/AKT signaling; EIF4A3 enhances its biogenesis."	0.8711
37626393	Biology direct	2023	CircRNA_15430 reduced by Helicobacter pylori infection and suppressed gastric cancer progression via miR-382-5p/ZCCHC14 axis.	hsa_circ_0015430	CircRNA_15430	hsa_circ_ABL2	abl2 / ABL2	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"circRNA_15430 (from ABL2) is down-regulated in gastric cancer and reduced by H. pylori infection. It mainly localizes to the cytoplasm and suppresses GC cell proliferation/migration while promoting apoptosis and autophagy, partly by acting as a ceRNA that sponges miR-382-5p to modulate ZCCHC14. In xenograft models, circRNA_15430 knockdown enhances tumor growth."	0.8429
37627085	Cancers	2023	CPSF3 Promotes Pre-mRNA Splicing and Prevents CircRNA Cyclization in Hepatocellular Carcinoma.	hsa_circ_0001380		hsa_circ_UBXN7	UBXN7	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"In HCC cells, CPSF3 suppresses hsa_circ_0001380 biogenesis (PAS-dependent shift from circRNA to linear UBXN7 mRNA). Reduced hsa_circ_0001380 is associated with decreased levels of its bound miRNAs (miR-622/miR-1247) and impaired miRNA-mediated gene silencing (e.g., E2F1)."	0.5005
37627085	Cancers	2023	CPSF3 Promotes Pre-mRNA Splicing and Prevents CircRNA Cyclization in Hepatocellular Carcinoma.	hsa_circ_0078607		hsa_circ_SLC22A3	SLC22A3	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"In HCC cells, CPSF3 suppresses hsa_circ_0078607 biogenesis (PAS-dependent shift from circRNA to linear SLC22A3 mRNA). Reduced hsa_circ_0078607 is associated with decreased levels of its bound miRNAs (miR-188/miR-1294) and impaired miRNA-mediated gene silencing (e.g., NCAPG2)."	0.5005
37632352	Cell transplantation	2023	Whole Blood-Derived circUSP10 Acts as a Diagnostic Biomarker in Patients With Early-Stage Non-Small-Cell Lung Cancer.	hsa_circ_0003026	circUSP10	hsa_circ_USP10	USP10	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circUSP10 (hsa_circ_0003026), derived from USP10, is up-regulated in NSCLC tumor tissues and in patients¡¯ whole blood. It is stable (RNase R resistant and longer half-life with actinomycin D) and shows strong ROC-based diagnostic performance for early-stage (TNM I) NSCLC."	0.6556
37635445	Thoracic cancer	2023	MiR-671-5p sponging activity of circMMP1 promotes esophageal squamous cancer progression.	hsa_circ_0024108	circMMP1	hsa_circ_MMP1		esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"circMMP1 is up-regulated in ESCC tissues and cell lines and is associated with shorter overall survival. Functionally, circMMP1 promotes ESCC proliferation, migration, invasion and EMT, and enhances tumor growth in vivo by sponging miR-671-5p to increase ANO1 expression."	0.7824
37639013	Journal of cancer research and clinical oncology	2023	Hsa_circ_0041150 serves as a novel biomarker for monitoring chemotherapy resistance in small cell lung cancer patients treated with a first-line chemotherapy regimen.	hsa_circ_0041150				small cell lung cancer / SCLC	MONDO:0008433	small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0041150 is up-regulated in chemoresistant SCLC cells and increases in patient serum and serum extracellular vesicles after resistance develops. Functionally, it promotes SCLC cell proliferation, migration/invasion, and cisplatin resistance, and it shows potential as a noninvasive biomarker to monitor chemotherapy resistance (enhanced when combined with NSE)."	0.7751
37639013	Journal of cancer research and clinical oncology	2023	Hsa_circ_0041150 serves as a novel biomarker for monitoring chemotherapy resistance in small cell lung cancer patients treated with a first-line chemotherapy regimen.	hsa_circ_0017286				small cell lung cancer / SCLC	MONDO:0008433	small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0017286 is up-regulated in chemoresistant SCLC (SHP77 vs H446) and is increased in patient serum and serum extracellular vesicles after chemotherapy resistance develops. The study supports its association with SCLC chemoresistance, but no specific downstream mechanism or functional assays are reported for this circRNA."	0.5909
37639013	Journal of cancer research and clinical oncology	2023	Hsa_circ_0041150 serves as a novel biomarker for monitoring chemotherapy resistance in small cell lung cancer patients treated with a first-line chemotherapy regimen.	hsa_circ_0040813				small cell lung cancer / SCLC	MONDO:0008433	small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0040813 is up-regulated in chemoresistant SCLC and increases in patient serum and serum extracellular vesicles after resistance develops. No direct functional mechanism or downstream axis is reported for this circRNA in the study.	0.5909
37639013	Journal of cancer research and clinical oncology	2023	Hsa_circ_0041150 serves as a novel biomarker for monitoring chemotherapy resistance in small cell lung cancer patients treated with a first-line chemotherapy regimen.	hsa_circ_0001187				small cell lung cancer / SCLC	MONDO:0008433	small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0001187 is up-regulated in chemoresistant SCLC and increases in serum extracellular vesicles after chemotherapy resistance develops. The paper does not report a specific molecular mechanism or functional phenotype experiments for this circRNA.	0.5909
37639013	Journal of cancer research and clinical oncology	2023	Hsa_circ_0041150 serves as a novel biomarker for monitoring chemotherapy resistance in small cell lung cancer patients treated with a first-line chemotherapy regimen.	hsa_circ_0003134				small cell lung cancer / SCLC	MONDO:0008433	small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0003134 is up-regulated in SCLC chemoresistance and increases in patient serum and serum extracellular vesicles after resistance develops. The study does not provide mechanistic or functional validation specific to this circRNA beyond expression and circularity-related validation performed on the circRNA set.	0.5541
37639013	Journal of cancer research and clinical oncology	2023	Hsa_circ_0041150 serves as a novel biomarker for monitoring chemotherapy resistance in small cell lung cancer patients treated with a first-line chemotherapy regimen.	hsa_circ_0000419				small cell lung cancer / SCLC	MONDO:0008433	small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0000419 is reported as up-regulated in chemoresistant SCLC patient serum and serum extracellular vesicles. The study does not provide mechanistic or functional characterization specific to this circRNA.	0.5541
37644235	Journal of cancer research and clinical oncology	2023	"Effects of hsa_circ_0074854 on colorectal cancer progression, construction of a circRNA-miRNA-mRNA network, and analysis of immune infiltration."	hsa_circ_0074854	circ_0074854 / hsa_circRNA_0074854			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"In colorectal cancer, hsa_circ_0074854 is up-regulated in tissues and CRC cell lines and acts as an oncogenic circRNA. Its knockdown suppresses proliferation/migration/invasion, induces G0/G1 arrest, and increases apoptosis. Mechanistically, it is proposed to function via a ceRNA axis by suppressing miR-2110 and thereby increasing ENO2 and IGF2BP3 expression, with downstream associations to immune cell infiltration through these target genes."	0.6111
37644421	BMC cancer	2023	Circ_0021350 plays an oncogene role by regulating miR-1207-3p/PIK3R3 in glioblastoma.	hsa_circ_0021350	circ_0021350	hsa_circ_SOX6	SOX6	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; RNA-seq	"circ_0021350 is up-regulated in glioblastoma tissues and glioma cell lines and promotes proliferation and metastatic phenotypes. It functions mainly as a ceRNA by sponging miR-1207-3p to derepress PIK3R3, and PIK3R3 overexpression rescues the inhibitory effects of circ_0021350 knockdown in vitro and in vivo."	0.8546
37647111	Molecular cancer research : MCR	2023	m6A-Mediated Biogenesis of circDDIT4 Inhibits Prostate Cancer Progression by Sequestrating ELAVL1/HuR.	hsa_circ_0018744	circDDIT4	hsa_circ_DDIT4	DDIT4	prostate cancer	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; Northern Blot	"circDDIT4 is down-regulated in prostate cancer tissues, serum, and cell lines and acts as a tumor suppressor. Mechanistically, circDDIT4 sponges the RBP ELAVL1/HuR via its 3¡ä-UTR, reducing ELAVL1-dependent expression/stability of targets such as ANO7, thereby promoting apoptosis and inhibiting proliferation and migration/metastasis. Its circularization/biogenesis is promoted by WTAP/METTL3/METTL14-mediated m6A modification and antagonized by FTO."	0.8524
37650285	Bioscience reports	2023	Identification of circRNA-associated ceRNA networks in peripheral blood mononuclear cells as potential biomarkers for chronic obstructive pulmonary disease.	hsa_circ_0067209		hsa_circ_EEFSEC	EEFSEC	chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR; Microarray	"hsa_circ_0067209 is up-regulated in PBMCs from COPD patients and shows diagnostic potential (especially combined with hsa_circ_0000673). Mechanistically, it directly binds hsa-miR-8082 and is linked to downstream target mRNAs including ABR and TRPM6 in a ceRNA network potentially involved in COPD pathogenesis."	0.6034
37650285	Bioscience reports	2023	Identification of circRNA-associated ceRNA networks in peripheral blood mononuclear cells as potential biomarkers for chronic obstructive pulmonary disease.	hsa_circ_0000673		hsa_circ_RSL1D1	RSL1D1	chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	down-regulated	RT-qPCR; Microarray	"hsa_circ_0000673 is down-regulated in PBMCs from COPD patients and contributes to a diagnostic signature when combined with hsa_circ_0067209. It directly binds hsa-miR-1248 and is linked to the downstream target RORC, forming a ceRNA axis suggested to influence COPD progression by regulating inflammatory responses."	0.6034
37652905	Cell death & disease	2023	CircMIB2 therapy can effectively treat pathogenic infection by encoding a novel protein.			circMIB2	MIB2	SCRV virus infection	MONDO:0005108	viral infectious disease	up-regulated	RT-qPCR; RNA-seq	"circMIB2 is induced during SCRV and V. anguillarum infection in miiuy croaker and mainly localizes to the cytoplasm. It is translated in an m6A-dependent manner to produce MIB2-134aa, which competes with host MIB2 for TRAF6 binding, reduces MIB2-driven ubiquitination/degradation of TRAF6, and enhances TRAF6-mediated innate immune responses, limiting viral replication and bacterial colonization; synthetic circMIB2 shows therapeutic efficacy in infected zebrafish."	0.8193
37653038	Experimental & molecular medicine	2023	CircFam190a: a critical positive regulator of osteoclast differentiation via enhancement of the AKT1/HSP90beta complex.	mmu_circ_0001477	circFam190a	mmu_circ_Fam190a	Fam190a	osteoporosis	MONDO:0005298	osteoporosis	up-regulated	RT-qPCR; RNA-seq	"circFam190a is up-regulated during osteoclastogenesis and in OVX osteoporosis mice, and promotes osteoclast differentiation and bone resorption. Mechanistically, it binds AKT1 and HSP90beta to enhance their complex formation, stabilizing AKT1 by reducing ubiquitination/proteasomal degradation and activating AKT signaling; targeting circFam190a alleviates pathological bone loss in the OVX model."	0.8225
37653038	Experimental & molecular medicine	2023	CircFam190a: a critical positive regulator of osteoclast differentiation via enhancement of the AKT1/HSP90beta complex.	hsa_circ_0127310	circFAM190A	hsa_circ_FAM190A	FAM190A	osteoporosis	MONDO:0005298	osteoporosis	up-regulated	RT-qPCR	"In PBMCs from postmenopausal women, circFAM190A (hsa_circ_0127310) is up-regulated in PMO patients. The paper proposes circFAM190A as a potential therapeutic target for osteoporosis based on its elevation and homology to the functional mouse circFam190a, but it does not experimentally define circFAM190A¡¯s mechanism in human cells."	0.2995
37662721	Heliyon	2023	Hsa_circRNA_0084043 promoting tumorigenesis in glioma through miR-577 sponging.	hsa_circ_0084043	circRNA_0084043 / circ_0084043			glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circRNA_0084043 is up-regulated in glioma tissues/cell lines and correlates with higher glioma grade. It promotes glioma proliferation, migration, invasion and xenograft growth by sponging miR-577, thereby relieving miR-577-mediated repression of SNX5 (circRNA_0084043/miR-577/SNX5 ceRNA axis). High circRNA_0084043 expression is associated with poorer patient survival."	0.7751
37664656	Oncology letters	2023	Integrated analysis of high_throughput sequencing reveals the regulatory potential of hsa_circ_0035431 in HNSCC.	hsa_circ_0035431		hsa_circ_CGNL1	CGNL1	head and neck squamous cell carcinoma / HNSCC	MONDO:0010150	head and neck squamous cell carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0035431 is downregulated in HNSCC tissues and cell lines. The study proposes a ceRNA mechanism where hsa_circ_0035431 sponges hsa-miR-940 to regulate FUT6 and CGNL1, potentially influencing HNSCC progression and prognosis."	0.5135
37664885	CNS neuroscience & therapeutics	2024	Transcriptome sequencing of circular RNA reveals the involvement of hsa-SCMH1_0001 in the pathogenesis of Parkinson's disease.		hsa_SCMH1_0001	hsa_circ_SCMH1	SCMH1	Parkinson's disease / PD	MONDO:0005180	Parkinson disease	down-regulated	RT-qPCR; RNA-seq	Plasma exosomal hsa-SCMH1_0001 is significantly down-regulated in Parkinson's disease patients. Lower expression correlates with worse motor symptoms (higher MDS-UPDRS III). A predicted ceRNA network suggests hsa-SCMH1_0001 may regulate ARID1A and C1orf115 via binding multiple miRNAs.	0.4032
37665075	Journal of cellular and molecular medicine	2024	USF1 regulated circPRDM4 modulates tumorigenesis and immune escape in chemoresistant cervical cancer.		circPRDM4	hsa_circ_PRDM4	PRDM4	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"circPRDM4 is up-regulated in cisplatin-chemoresistant cervical cancer cells and promotes chemoresistance, immune escape, and malignant phenotypes (proliferation, migration, invasion). USF1 transcriptionally induces circPRDM4, forming a USF1/circPRDM4 axis that drives these behaviors."	0.7735
37667251	BMC cancer	2023	circFNDC3B promotes esophageal squamous cell carcinoma progression by targeting MYO5A via miR-370-3p/miR-136-5p.	hsa_circ_0001361	circFNDC3B	hsa_circ_FNDC3B	FNDC3B	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"circFNDC3B is up-regulated in ESCC tissues and cell lines and promotes proliferation while inhibiting apoptosis. Mechanistically, it functions as a ceRNA sponge for miR-370-3p and miR-136-5p to increase MYO5A expression, enhancing ESCC progression and tumor growth in xenografts; it also shows diagnostic potential by ROC analysis."	0.8094
37667322	Journal of experimental & clinical cancer research : CR	2023	Circadian gene ARNTL initiates circGUCY1A2 transcription to suppress non-small cell lung cancer progression via miR-200c-3p/PTEN signaling.	hsa_circ_0008602	circ_0008602 / circGUCY1A2	hsa_circ_GUCY1A3	GUCY1A3	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"circGUCY1A2 is down-regulated in NSCLC and functions as a tumor suppressor by inhibiting proliferation and promoting apoptosis. It sponges miR-200c-3p to restore PTEN and suppress PI3K/AKT signaling; ARNTL transcriptionally upregulates circGUCY1A2 by binding its promoter, and higher circGUCY1A2 is associated with better patient survival."	0.8557
37669906	Thoracic cancer	2023	N6 -methyladenosine-modified circFUT8 competitively interacts with YTHDF2 and miR-186-5p to stabilize FUT8 mRNA to promote malignant progression in lung adenocarcinoma.	hsa_circ_0003028	circFUT8	hsa_circ_FUT8	FUT8	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"In LUAD, circFUT8 (hsa_circ_0003028) is up-regulated and mainly localized in the cytoplasm. It promotes malignant progression by stabilizing FUT8 mRNA via competitive interaction with the m6A reader YTHDF2 and by sponging miR-186-5p to increase FUT8 expression, thereby enhancing invasion and metastasis."	0.8624
37670963	Journal of Cancer	2023	circROBO1 promotes prostate cancer growth and enzalutamide resistance via accelerating glycolysis.	hsa_circ_0124696	circROBO1	hsa_circ_ROBO1	ROBO1	prostate cancer	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circROBO1 (hsa_circ_0124696) is up-regulated in prostate cancer tissues and cell lines and mainly localized in the cytoplasm. It promotes proliferation, enhances glycolysis, and increases enzalutamide resistance by sponging miR-556-5p to upregulate the glycolytic enzyme PGK1."	0.8246
37673874	Nature communications	2023	"Exosomal circEZH2_005, an intestinal injury biomarker, alleviates intestinal ischemia/reperfusion injury by mediating Gprc5a signaling."		circEZH2_005 / circ-EZH2_005	mmu_circ_Ezh2	Ezh2	intestinal ischemia/reperfusion injury	MONDO:0005203	ischemia reperfusion injury	down-regulated	RT-qPCR; RNA-seq	"circEZH2_005 is down-regulated in intestinal I/R (mouse intestinal exosomes/tissue and patient plasma exosomes) and has diagnostic value for postoperative intestinal I/R injury. Functionally, circEZH2_005 alleviates I/R-induced intestinal mucosal damage by promoting Lgr5+ crypt stem cell proliferation via binding hnRNPA1 and increasing Gprc5a mRNA stability."	0.875
37674577	Frontiers in cellular and infection microbiology	2023	CircRNAs in BALF exosomes and plasma as diagnostic biomarkers in patients with acute respiratory distress syndrome caused by severe pneumonia.		hsa_circRNA_042882 / circ042882			acute respiratory distress syndrome / ARDS	MONDO:0006502	acute respiratory distress syndrome	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_042882 is down-regulated in BALF exosomes and plasma from ARDS patients caused by severe pneumonia and shows diagnostic value by ROC analysis. The study also proposes a ceRNA regulatory network for this circRNA involving miR-199a/b-5p and miR-34b-5p with target genes such as HIF1A and NFKBIA, linking it to hypoxia/inflammation-related processes."	0.5047
37674577	Frontiers in cellular and infection microbiology	2023	CircRNAs in BALF exosomes and plasma as diagnostic biomarkers in patients with acute respiratory distress syndrome caused by severe pneumonia.		hsa_circRNA_104034 / circ104034			acute respiratory distress syndrome / ARDS	MONDO:0006502	acute respiratory distress syndrome	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_104034 is up-regulated in BALF exosomes and plasma from ARDS patients caused by severe pneumonia and demonstrates diagnostic performance by ROC analysis. The study constructs a predicted ceRNA axis involving miR-34b-3p and MAP2K4, and enrichment results associate targets with hypoxia/inflammation-related pathways including HIF-1 signaling."	0.5047
37675591	Thoracic cancer	2023	CircPKM2 aggravates the progression of non-small cell lung cancer by regulating MTDH via miR-1298-5p.	hsa_circ_0036200	circPKM2	hsa_circ_PKM2	PKM2	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circPKM2 is upregulated in NSCLC tissues and cell lines and mainly localizes to the cytoplasm. It promotes NSCLC malignant phenotypes and xenograft growth by sponging miR-1298-5p, thereby increasing MTDH expression."	0.8443
37679886	Clinical and translational medicine	2023	METTL3-mediated m6 A modification of circPRKAR1B promotes Crohn's colitis by inducing pyroptosis via autophagy inhibition.	hsa_circ_0008039	circPRKAR1B	hsa_circ_PRKAR1B	PRKAR1B	Crohn's disease / CD	MONDO:0005011	Crohn disease	up-regulated	RT-qPCR; ISH; RNA-seq	"circPRKAR1B (hsa_circ_0008039) is upregulated in Crohn¡¯s disease/colitis colon tissues, particularly in epithelial layers. METTL3-mediated m6A modification promotes its elevated expression, and circPRKAR1B binds SPTBN1 to inhibit autophagy and enhance NLRP3 inflammasome-mediated pyroptosis, aggravating intestinal inflammation."	0.8064
37680984	Molecular therapy. Nucleic acids	2023	The circular RNA Ataxia Telangiectasia Mutated regulates oxidative stress in smooth muscle cells in expanding abdominal aortic aneurysms.	hsa_circ_0003641	cATM / circular ATM	hsa_circ_ATM	ATM	abdominal aortic aneurysm / AAA	MONDO:0005350	abdominal aortic aneurysm	up-regulated	RT-qPCR; ISH; Microarray	"cATM (hsa_circ_0003641), derived from the ATM locus, is up-regulated in AAA aortic tissue, AAA-derived smooth muscle cells, and patient serum. Functionally, higher cATM is associated with reduced vulnerability to oxidative stress and reduced apoptosis in AAA-derived AoSMCs, while cATM knockdown increases apoptosis and alters ATM mRNA regulation, supporting its role as an adaptive stress-response signature and potential circulating biomarker for AAA."	0.6816
37681495	International journal of molecular medicine	2023	Characterization of circRNAs in established osimertinib_resistant non_small cell lung cancer cell lines.	hsa_circ_0070467	circP-DLIM5 / circPDLIM5	hsa_circ_PDLIM5	PDLIM5	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	"circPDLIM5 (hsa_circ_0070467) is down-regulated in osimertinib-resistant HCC827-OR cells. Functionally, circPDLIM5 acts as a suppressive circRNA in the resistant context: its knockdown enhances proliferation, migration and angiogenesis and reduces apoptosis, while overexpression shows opposite effects."	0.6874
37681495	International journal of molecular medicine	2023	Characterization of circRNAs in established osimertinib_resistant non_small cell lung cancer cell lines.	hsa_circ_0007509	circPPP4R1	hsa_circ_PPP4R1	PPP4R1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"circPPP4R1 (hsa_circ_0007509) is up-regulated in osimertinib-resistant H1975-OR cells. Functionally, circPPP4R1 supports the resistant phenotype by promoting proliferation, migration and angiogenesis and suppressing apoptosis; silencing it increases sensitivity to osimertinib in H1975-OR cells."	0.6873
37684515	Journal of molecular neuroscience : MN	2023	Identification of Novel Circular RNA Targets in Key Penumbra Region of Rats After Cerebral Ischemia-Reperfusion Injury.		circ.7225 / circRNA.7225			cerebral ischemia-reperfusion injury	MONDO:0005203	ischemia reperfusion injury	down-regulated	RT-qPCR; RNA-seq	"In rat penumbra after cerebral ischemia-reperfusion injury, circ.7225 is significantly downregulated at 24 h and 72 h. The study proposes a ceRNA mechanism in which circ.7225 targets miR-298-5p and is linked to Bcl-3 within a circRNA-miRNA-mRNA network."	0.4851
37684515	Journal of molecular neuroscience : MN	2023	Identification of Novel Circular RNA Targets in Key Penumbra Region of Rats After Cerebral Ischemia-Reperfusion Injury.		circ.5415 / circ5415			cerebral ischemia-reperfusion injury	MONDO:0005203	ischemia reperfusion injury	down-regulated	RT-qPCR; RNA-seq	circ.5415 is significantly downregulated in rat penumbra after cerebral ischemia-reperfusion injury at both 24 h and 72 h. It is included in a predicted ceRNA network and is proposed to target miR-298-5p with downstream association to Bcl-3.	0.4851
37684515	Journal of molecular neuroscience : MN	2023	Identification of Novel Circular RNA Targets in Key Penumbra Region of Rats After Cerebral Ischemia-Reperfusion Injury.		circ.20623			cerebral ischemia-reperfusion injury	MONDO:0005203	ischemia reperfusion injury	down-regulated	RT-qPCR; RNA-seq	circ.20623 is significantly downregulated in rat penumbra after cerebral ischemia-reperfusion injury at both 24 h and 72 h. The study builds a predicted circRNA-miRNA-mRNA (ceRNA) network and identifies a shared miR-298-5p/Bcl-3 axis involving circ.20623.	0.4851
37684641	Molecular cancer	2023	CircXRN2 suppresses tumor progression driven by histone lactylation through activating the Hippo pathway in human bladder cancer.	hsa_circ_0001134	circXRN2	hsa_circ_XRN2	XRN2	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"circXRN2 (hsa_circ_0001134) is down-regulated in human bladder cancer and suppresses tumor proliferation, migration, and in vivo growth/metastasis while reducing glycolysis and lactate production. Mechanistically, it binds LATS1 at the SPOP-binding degron to prevent SPOP-mediated ubiquitination/degradation, activates Hippo signaling (TAZ/YAP inhibition), and thereby reduces H3K18 lactylation and LCN2 expression."	0.7752
37686043	International journal of molecular sciences	2023	Circular RNA hsa_circ_0049657 as a Potential Biomarker in Non-Small Cell Lung Cancer.	hsa_circ_0049657		hsa_circ_NFIX	NFIX	Non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"hsa_circ_0049657 (derived from NFIX) is down-regulated in NSCLC tissues and cell lines. Its overexpression suppresses NSCLC cell proliferation and migration/invasion and increases apoptosis, suggesting a tumor-suppressive role and potential biomarker value, although the molecular mechanism was not determined."	0.5358
37689715	Molecular cancer	2023	circEIF3I facilitates the recruitment of SMAD3 to early endosomes to promote TGF-beta signalling pathway-mediated activation of MMPs in pancreatic cancer.	hsa_circ_0011385	circEIF3I / hsa_circ_100146	hsa_circ_EIF3I	EIF3I	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circEIF3I is up-regulated in PDAC and promotes migration, invasion and metastasis. It acts as a cytoplasmic scaffold binding SMAD3 and AP2A1, enhancing SMAD3 recruitment to TGFbetaRI on early endosomes, increasing SMAD3 phosphorylation and activating TGF-beta-driven MMP expression/activity. High circEIF3I expression correlates with advanced stage and poor prognosis, suggesting prognostic/therapeutic potential."	0.8871
37689715	Molecular cancer	2023	circEIF3I facilitates the recruitment of SMAD3 to early endosomes to promote TGF-beta signalling pathway-mediated activation of MMPs in pancreatic cancer.	mmu_circ_0001266	circEif3i	mmu_circ_Eif3i	Eif3i	pancreatic cancer	MONDO:0009831	malignant pancreatic neoplasm	unknown	RT-qPCR	The mouse homolog circEif3i (mmu_circ_0001266) promotes invasion and metastasis in pancreatic cancer models. Its knockdown reduces TGF-beta-induced SMAD3 phosphorylation and is associated with reduced metastatic burden in orthotopic and liver metastasis models.	0.7148
37691924	Frontiers in immunology	2023	"Integrative transcriptomic profiling of mRNA, miRNA, circRNA, and lncRNA in alveolar macrophages isolated from PRRSV-infected porcine."		circSPECC1 (2).1	ssc_circ_SPECC1	SPECC1	porcine reproductive and respiratory syndrome / PRRS	MONDO:0025494	porcine reproductive and respiratory syndrome	dysregulated	RT-qPCR; RNA-seq	circSPECC1 (2).1 is a differentially expressed circRNA in porcine alveolar macrophages after PRRSV infection. It is predicted to act in a circRNA-miRNA-mRNA network by interacting with ssc-miR-4332 to modulate expression of immune/virus-response-related genes.	0.62
37691924	Frontiers in immunology	2023	"Integrative transcriptomic profiling of mRNA, miRNA, circRNA, and lncRNA in alveolar macrophages isolated from PRRSV-infected porcine."		"circSFMBT2 (2,3,4).1 / circSFMBT1 (2,3,4).1"	ssc_circ_SFMBT2	SFMBT2	porcine reproductive and respiratory syndrome / PRRS	MONDO:0025494	porcine reproductive and respiratory syndrome	dysregulated	RT-qPCR; RNA-seq	"circSFMBT2 (2,3,4).1 (also written as circSFMBT1 (2,3,4).1 in the RT-qPCR figure caption) is a hub differentially expressed circRNA during PRRSV infection in porcine alveolar macrophages. It was selected for RT-qPCR validation, but the provided text does not specify its miRNA/mRNA targets or detailed mechanism."	0.62
37691924	Frontiers in immunology	2023	"Integrative transcriptomic profiling of mRNA, miRNA, circRNA, and lncRNA in alveolar macrophages isolated from PRRSV-infected porcine."		circNPL(L3).1	ssc_circ_NPL	NPL	porcine reproductive and respiratory syndrome / PRRS	MONDO:0025494	porcine reproductive and respiratory syndrome	down-regulated	RT-qPCR; RNA-seq	"circNPL(L3).1 is downregulated in porcine alveolar macrophages during PRRSV infection and is part of the constructed circRNA-miRNA-mRNA network. It was further validated by RT-qPCR, but specific interacting miRNAs/mRNAs were not provided in the text."	0.62
37691924	Frontiers in immunology	2023	"Integrative transcriptomic profiling of mRNA, miRNA, circRNA, and lncRNA in alveolar macrophages isolated from PRRSV-infected porcine."		"circAFF3(L4,5,6).1"	ssc_circ_AFF3	AFF3	porcine reproductive and respiratory syndrome / PRRS	MONDO:0025494	porcine reproductive and respiratory syndrome	unknown	RNA-seq	"circAFF3(L4,5,6).1 is implicated by network analysis as a potential regulator during PRRSV infection, predicted to modulate multiple mRNAs (e.g., ITGB2, DDX60, SLC2A6) through binding ssc-miR-149. Its differential-expression direction was not stated in the provided text, and it was not included among the RT-qPCR-validated circRNAs."	0.4575
37691924	Frontiers in immunology	2023	"Integrative transcriptomic profiling of mRNA, miRNA, circRNA, and lncRNA in alveolar macrophages isolated from PRRSV-infected porcine."		"circNBR1(14,L15).1"	ssc_circ_NBR1	NBR1	porcine reproductive and respiratory syndrome / PRRS	MONDO:0025494	porcine reproductive and respiratory syndrome	unknown	RNA-seq	"circNBR1(14,L15).1 is implicated by network analysis in PRRSV-infected porcine alveolar macrophages and is predicted to regulate multiple mRNAs (including CTLA4 and VEGFA) via interaction with ssc-miR-7135-3p. It was not among the circRNAs reported as RT-qPCR-validated in the provided text."	0.4575
37691924	Frontiers in immunology	2023	"Integrative transcriptomic profiling of mRNA, miRNA, circRNA, and lncRNA in alveolar macrophages isolated from PRRSV-infected porcine."		circNUP205 (40).1	ssc_circ_NUP205	NUP205	porcine reproductive and respiratory syndrome / PRRS	MONDO:0025494	porcine reproductive and respiratory syndrome	up-regulated	RNA-seq	"circNUP205 (40).1 is implicated in the ceRNA network during PRRSV infection and is described as concurrently upregulated with CTLA4-associated RNAs, potentially contributing to immune suppression. The mechanism is presented as ceRNA association via ssc-miRA-7135-3p, but this circRNA was not reported as RT-qPCR-validated in the provided text."	0.4575
37691924	Frontiers in immunology	2023	"Integrative transcriptomic profiling of mRNA, miRNA, circRNA, and lncRNA in alveolar macrophages isolated from PRRSV-infected porcine."		"circF13A1 (4,5,6).1"	ssc_circ_F13A1	F13A1	porcine reproductive and respiratory syndrome / PRRS	MONDO:0025494	porcine reproductive and respiratory syndrome	unknown	RNA-seq	"circF13A1 (4,5,6).1 is included in the ceRNA network linked to regulation of SAMHD1 during PRRSV infection, presumably via interaction with ssc-miR-106a. The text provided does not report its expression direction or RT-qPCR validation status."	0.4575
37692283	iScience	2023	CircMAPK9 promotes adipogenesis through modulating hsa-miR-1322/FTO axis in obesity.	hsa_circ_0001566	circMAPK9	hsa_circ_MAPK9	MAPK9	obesity	MONDO:0011122	obesity disorder	up-regulated	RT-qPCR; RNA-seq	"In obesity (VATs), circMAPK9 is up-regulated and positively correlates with BMI. It promotes adipogenesis by sponging hsa-miR-1322 in the cytoplasm, thereby relieving repression of FTO and increasing adipogenic markers and lipid accumulation; it also shows diagnostic value by ROC analysis."	0.8632
37692283	iScience	2023	CircMAPK9 promotes adipogenesis through modulating hsa-miR-1322/FTO axis in obesity.		mmu-circMAPK9	mmu_circ_MAPK9		obesity	MONDO:0011122	obesity disorder	unknown	RT-qPCR	"In an HFD-induced obese mouse model, silencing mmu-circMAPK9 reduces liver ectopic lipid accumulation and decreases adipocyte size in iWAT/eWAT, alongside improved plasma TG/TC and glucose tolerance."	0.5223
37692338	Pharmacogenomics and personalized medicine	2023	Hsa_circ_0003489 Drives PTX Resistance of Human NSCLC Cells Through Modulating miR-98-5p/IGF2.	hsa_circ_0003489		hsa_circ_CDK8	CDK8	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0003489 is up-regulated in paclitaxel-resistant NSCLC tissues and resistant cell models. Silencing hsa_circ_0003489 reduces PTX IC50 and inhibits cell growth by sponging miR-98-5p and downregulating IGF2, indicating a ceRNA axis that promotes chemoresistance."	0.7688
37692475	Genes & diseases	2024	Targeted nanopore sequencing for the identification of novel PRMT1 circRNAs unveils a diverse transcriptional profile of this gene in breast cancer cells.		circ-PRMT1-68	hsa_circ_PRMT1	PRMT1	breast cancer / BC	MONDO:0007254	breast cancer	unknown	RNA-seq	"circ-PRMT1-68 is a PRMT1-derived circRNA detected by targeted nanopore circRNA sequencing in breast cancer cells. The study predicts miRNA-binding sites (miR-4284 and miR-24-3p), suggesting a potential miRNA-sponge role that may affect breast cancer cell survival, but this function is not experimentally validated."	0.3528
37692475	Genes & diseases	2024	Targeted nanopore sequencing for the identification of novel PRMT1 circRNAs unveils a diverse transcriptional profile of this gene in breast cancer cells.		PRMT1-60 / circ-PRMT1-60	hsa_circ_PRMT1	PRMT1	breast cancer / BC	MONDO:0007254	breast cancer	unknown	RNA-seq	"PRMT1-60/circ-PRMT1-60 is a PRMT1-derived circRNA with a 3¡ä-extension of exon 12 identified in SK-BR-3 breast cancer cells by targeted nanopore circRNA sequencing. The study predicts a miR-361-3p binding site, suggesting a possible miRNA-sponge role relevant to breast cancer cell survival, without experimental functional validation."	0.3528
37692475	Genes & diseases	2024	Targeted nanopore sequencing for the identification of novel PRMT1 circRNAs unveils a diverse transcriptional profile of this gene in breast cancer cells.		circ-PRMT1-61	hsa_circ_PRMT1	PRMT1	breast cancer / BC	MONDO:0007254	breast cancer	unknown	RNA-seq	"circ-PRMT1-61 is a PRMT1-derived circRNA with a 3¡ä-extension of exon 12 identified in SK-BR-3 breast cancer cells by targeted nanopore circRNA sequencing. The study predicts a miR-361-3p binding site and proposes a potential miRNA-sponge role relevant to breast cancer cell survival, without direct experimental validation."	0.3528
37693837	"Open medicine (Warsaw, Poland)"	2023	"Circ-UBR4 regulates the proliferation, migration, inflammation, and apoptosis in ox-LDL-induced vascular smooth muscle cells via miR-515-5p/IGF2 axis."	hsa_circ_0010283	Circ-UBR4	hsa_circ_UBR4	UBR4	atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"circ-UBR4 is up-regulated in atherosclerosis patient serum and in ox-LDL-induced VSMCs. It predominantly localizes to the cytoplasm and promotes VSMC proliferation, migration, and inflammatory cytokine production while inhibiting apoptosis by sponging miR-515-5p to derepress IGF2 (circ-UBR4/miR-515-5p/IGF2 axis)."	0.783
37694359	Clinical hemorheology and microcirculation	2024	Hsa_ circ_0006867 regulates ox-LDL-induced endothelial injury via the miR-499a-3p/ADAM10 axis.	hsa_circ_0006867	circ_0006867	hsa_circ_LRBA	LRBA	atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"In ox-LDL-treated HUVECs (an in vitro atherosclerosis injury model), circ_0006867 is up-regulated and mainly localized in the cytoplasm. It sponges miR-499a-3p to modulate ADAM10 expression, thereby reducing apoptosis and supporting endothelial cell migration/viability under ox-LDL-induced injury."	0.7626
37698263	The Kaohsiung journal of medical sciences	2023	Circ_0084188 promotes colorectal cancer progression by sponging miR-654-3p and regulating kruppel-like factor 12.	hsa_circ_0084188	circ_0084188	hsa_circ_SPIDR	SPIDR	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0084188 is up-regulated in colorectal cancer tissues/cells and mainly localizes to the cytoplasm. It promotes CRC proliferation, migration, invasion, stemness and tumor growth while inhibiting apoptosis by sponging miR-654-3p to upregulate KLF12 (circ_0084188/miR-654-3p/KLF12 ceRNA axis). High circ_0084188 expression is associated with advanced clinical stage."	0.8465
37699956	Scientific reports	2023	Construction of a novel circRNA-miRNA-ferroptosis related mRNA network in ischemic stroke.	hsa_circ_0071036				ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	Microarray	This circRNA was identified bioinformatically as an up-regulated circRNA in ischemic stroke blood samples and is proposed to act in a ceRNA axis by sponging hsa-miR-122-5p to regulate DUSP1 (a ferroptosis-related mRNA) in IS.	0.1768
37699956	Scientific reports	2023	Construction of a novel circRNA-miRNA-ferroptosis related mRNA network in ischemic stroke.	hsa_circ_0039365				ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	Microarray	This circRNA was identified bioinformatically as an up-regulated circRNA in ischemic stroke blood and included in a proposed ceRNA module where it sponges hsa-miR-122-5p to regulate DUSP1.	0.1768
37699956	Scientific reports	2023	Construction of a novel circRNA-miRNA-ferroptosis related mRNA network in ischemic stroke.	hsa_circ_0079347				ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	Microarray	This circRNA was identified bioinformatically as an up-regulated circRNA in ischemic stroke blood and included in a proposed ceRNA module regulating DUSP1 via hsa-miR-122-5p.	0.1768
37699956	Scientific reports	2023	Construction of a novel circRNA-miRNA-ferroptosis related mRNA network in ischemic stroke.	hsa_circ_0008857				ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	Microarray	This circRNA was identified bioinformatically as an up-regulated circRNA in ischemic stroke blood and included in a proposed ceRNA module regulating DUSP1 via hsa-miR-122-5p.	0.1768
37699956	Scientific reports	2023	Construction of a novel circRNA-miRNA-ferroptosis related mRNA network in ischemic stroke.	hsa_circ_0067717				ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	Microarray	"This circRNA was identified in a bioinformatically constructed ferroptosis-related ceRNA network for ischemic stroke, potentially modulating SLC2A3 via hsa-miR-4446-3p."	0.1768
37699956	Scientific reports	2023	Construction of a novel circRNA-miRNA-ferroptosis related mRNA network in ischemic stroke.	hsa_circ_0003956				ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	Microarray	This circRNA was included in the predicted ischemic stroke ferroptosis-related ceRNA network (hsa-miR-4446-3p/SLC2A3). No experimental validation for this specific circRNA was reported.	0.1768
37699956	Scientific reports	2023	Construction of a novel circRNA-miRNA-ferroptosis related mRNA network in ischemic stroke.	hsa_circ_0013729				ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	Microarray	This circRNA was included in the predicted ischemic stroke ferroptosis-related ceRNA network (hsa-miR-4446-3p/SLC2A3). No direct experimental validation for this specific circRNA was reported.	0.1768
37699956	Scientific reports	2023	Construction of a novel circRNA-miRNA-ferroptosis related mRNA network in ischemic stroke.	hsa_circ_0059347				ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	Microarray	"This circRNA was included in a predicted ferroptosis-related ceRNA network for ischemic stroke, potentially modulating SLC2A3 by binding hsa-miR-885-3p."	0.1768
37699956	Scientific reports	2023	Construction of a novel circRNA-miRNA-ferroptosis related mRNA network in ischemic stroke.	hsa_circ_0001414				ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	Microarray	This circRNA was included in the predicted ischemic stroke ferroptosis-related ceRNA network via hsa-miR-885-3p targeting SLC2A3. No circRNA-specific experimental validation was reported for it.	0.1768
37699956	Scientific reports	2023	Construction of a novel circRNA-miRNA-ferroptosis related mRNA network in ischemic stroke.	hsa_circ_0049637				ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	Microarray	This circRNA (also mentioned as Hsa-circ-0049637) was included as an up-regulated circRNA in a predicted ischemic stroke ferroptosis-related ceRNA network via hsa-miR-885-3p/SLC2A3.	0.1768
37699956	Scientific reports	2023	Construction of a novel circRNA-miRNA-ferroptosis related mRNA network in ischemic stroke.	hsa_circ_0005633				ischemic stroke / IS	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR; Microarray	"hsa_circ_0005633 was validated by RT-PCR as down-regulated in ischemic stroke blood samples. It is included in a proposed ferroptosis-related ceRNA module with hsa-miR-4435 and NCOA4, potentially contributing to ischemia-reperfusion processes."	0.4032
37699956	Scientific reports	2023	Construction of a novel circRNA-miRNA-ferroptosis related mRNA network in ischemic stroke.	hsa_circ_0004479				ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	Microarray	"hsa_circ_0004479 was bioinformatically implicated as up-regulated in ischemic stroke and placed in a proposed ferroptosis-related ceRNA axis with hsa-miR-4435 and NCOA4, potentially contributing to ischemia-reperfusion processes. It was not RT-PCR validated in this study."	0.1768
37705041	Journal of experimental & clinical cancer research : CR	2023	Circ-RAPGEF5 promotes intrahepatic cholangiocarcinoma progression by stabilizing SAE1 to facilitate SUMOylation.	hsa_circ_0001681	Circ-RAPGEF5 / CircRAPGEF5	hsa_circ_RAPGEF5	RAPGEF5	intrahepatic cholangiocarcinoma / ICC	MONDO:0003210	intrahepatic cholangiocarcinoma	up-regulated	RT-qPCR; RNA-seq	"Circ-RAPGEF5 (hsa_circ_0001681), derived from RAPGEF5, is up-regulated in intrahepatic cholangiocarcinoma and promotes proliferation, migration/invasion, and metastasis while inhibiting apoptosis. Mechanistically, it sponges miR-3185 to stabilize SAE1, enhancing global SUMOylation and AKT SUMOylation. High Circ-RAPGEF5 expression is associated with poorer patient survival."	0.8929
37711054	Oncology reports	2023	Circular RNA circBLNK promotes osteosarcoma progression and inhibits ferroptosis in osteosarcoma cells by sponging miR_188_3p and regulating GPX4 expression.		circBLNK	hsa_circ_BLNK	BLNK	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; RNA-seq	"circBLNK is upregulated in osteosarcoma tissues/cell lines and promotes tumor cell proliferation and in vivo tumor growth. It acts mainly in the cytoplasm as a ceRNA that sponges miR-188-3p to increase GPX4 expression, thereby inhibiting ferroptosis and reducing apoptosis, and high circBLNK expression correlates with poor patient survival."	0.8276
37716232	Poultry science	2023	Dietary Morus alba L. leaf supplementation improves hepatic lipid accumulation of laying hens via downregulating CircACACA.	gga_circ_0000429	CircACACA / novel_circ_0000429	gga_circ_ACACA	ACACA	Fatty liver hemorrhagic syndrome / FLHS	MONDO:0005021	dilated cardiomyopathy	down-regulated	RT-qPCR; RNA-seq	"In laying hens with FLHS, circACACA (derived from ACACA exons 2_3) is reduced by dietary mulberry leaf supplementation in liver. Functionally, circACACA overexpression in primary hepatocytes counteracts mulberry leaf extract_mediated lipid lowering by increasing triglyceride accumulation and upregulating SREBP-1c and FASN, indicating a pro-lipogenesis role."	0.7205
37716232	Poultry science	2023	Dietary Morus alba L. leaf supplementation improves hepatic lipid accumulation of laying hens via downregulating CircACACA.	gga_circ_0001534	circFDFT1 / circ_0001534	gga_circ_FDFT1	FDFT1	Fatty liver hemorrhagic syndrome / FLHS	MONDO:0005021	dilated cardiomyopathy	unknown	RT-qPCR; RNA-seq	circFDFT1 (circ_0001534) was among the circRNAs whose liver expression was validated by RT-qPCR in the FLHS laying-hen study comparing CON vs MUL diets. The paper does not report a specific functional mechanism or direction of change for circFDFT1 in the provided text.	0.3588
37716232	Poultry science	2023	Dietary Morus alba L. leaf supplementation improves hepatic lipid accumulation of laying hens via downregulating CircACACA.	gga_circ_0002498	circSUCO / circ_0002498	gga_circ_SUCO	SUCO	Fatty liver hemorrhagic syndrome / FLHS	MONDO:0005021	dilated cardiomyopathy	unknown	RT-qPCR; RNA-seq	circSUCO (circ_0002498) was included among circRNAs validated by RT-qPCR in liver samples from the FLHS laying-hen diet intervention study. The provided text does not describe a specific mechanistic role or a clear direction of dysregulation for circSUCO.	0.3588
37723137	Nature communications	2023	Circular RNAs in the human brain are tailored to neuron identity and neuropsychiatric disease.		circDNAJC6	hsa_circ_DNAJC6	DNAJC6	Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	dysregulated	RT-qPCR; RNA-seq	"circDNAJC6 (from the DNAJC6 PD gene locus) is altered in expression in dopamine neurons at early/prodromal Parkinson¡¯s disease-related Lewy body stages, suggesting it may be involved in early synapse-related molecular changes in PD."	0.5135
37723137	Nature communications	2023	Circular RNAs in the human brain are tailored to neuron identity and neuropsychiatric disease.		circPSEN1-2	hsa_circ_PSEN1	PSEN1	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	unknown	RT-qPCR; RNA-seq	"circPSEN1-2 is a PSEN1-derived circRNA highly expressed in human brain neurons and strongly enriched after RNase R treatment, supporting it as a validated circular transcript from a familial Alzheimer¡¯s disease locus; disease-related differential expression was not reported."	0.4773
37723137	Nature communications	2023	Circular RNAs in the human brain are tailored to neuron identity and neuropsychiatric disease.		circERC1-1	hsa_circ_ERC1	ERC1	Neuropsychiatric disease	MONDO:0005084	mental disorder	unknown	RT-qPCR; RNA-seq	"circERC1-1 is an ERC1-derived circRNA showing dopamine neuron-preferential expression in human brain, validated by qPCR with RNase R; no disease-stage differential expression or mechanistic axis was reported for this circRNA."	0.3401
37723137	Nature communications	2023	Circular RNAs in the human brain are tailored to neuron identity and neuropsychiatric disease.		circERC1-2	hsa_circ_ERC1	ERC1	Neuropsychiatric disease	MONDO:0005084	mental disorder	unknown	RT-qPCR; RNA-seq	"circERC1-2 is an ERC1-derived circRNA showing pyramidal neuron-preferential expression in human brain, validated by qPCR with RNase R; no disease-stage differential expression or mechanistic axis was reported for this circRNA."	0.3401
37723588	Journal of experimental & clinical cancer research : CR	2023	CircRNF10 triggers a positive feedback loop to facilitate progression of glioblastoma via redeploying the ferroptosis defense in GSCs.	hsa_circ_0028912	circRNF10	hsa_circ_RNF10	RNF10	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; RNA-seq	"circRNF10 (hsa_circ_0028912) is up-regulated in glioblastoma/glioma and high expression associates with poor prognosis. It promotes GSC proliferation and stemness by inhibiting ferroptosis and remodeling iron metabolism, via binding/stabilizing ZBTB48 (through blocking MKRN3-mediated ubiquitination) and forming a positive feedback loop with ZBTB48-driven IGF2BP3 and IGF2BP3-mediated circRNF10 stabilization, with downstream HSPB1 upregulation."	0.8991
37727322	"Open medicine (Warsaw, Poland)"	2023	Knockdown of circ_0005615 enhances the radiosensitivity of colorectal cancer by regulating the miR-665/NOTCH1 axis.	hsa_circ_0005615	circ_0005615	hsa_circ_NFATC3		colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0005615 is up-regulated in colorectal cancer and mainly localized in the cytoplasm. It promotes radioresistance by sponging miR-665 to upregulate NOTCH1, thereby supporting CRC cell survival/proliferation and migration/invasion while reducing apoptosis; its knockdown increases radiosensitivity in vitro and in a LOVO xenograft model."	0.6837
37737195	Journal of orthopaedic surgery and research	2023	Circ_0000396 suppresses the proliferation and inflammation of rheumatoid arthritis synovial fibroblasts by targeting miR-574-5p/RSPO1 axis.	hsa_circ_0000396	circ_0000396	hsa_circ_SLC38A1	SLC38A1	rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	down-regulated	RT-qPCR	"circ_0000396 is down-regulated in serum from rheumatoid arthritis patients. In RASFs, circ_0000396 overexpression inhibits proliferation and inflammatory cytokine production and promotes apoptosis by sponging miR-574-5p to de-repress RSPO1."	0.7595
37744239	PeerJ	2023	Expression profiles of circular RNAs and interaction networks of competing endogenous RNAs in neurogenic bladder of rats following suprasacral spinal cord injury.		circRNA3621 / circRNA 3621	rno_circ_Fbxw7	Fbxw7	suprasacral spinal cord injury / SSCI	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR; RNA-seq	"circRNA3621 (host gene Fbxw7) is significantly up-regulated in rat bladder tissue during SSCI-induced neurogenic bladder/bladder fibrosis across multiple time points, supported by RNA-seq and qRT-PCR. Its mechanistic role is not experimentally defined in this study, but it is part of predicted circRNA_miRNA_mRNA regulatory networks."	0.4997
37744239	PeerJ	2023	Expression profiles of circular RNAs and interaction networks of competing endogenous RNAs in neurogenic bladder of rats following suprasacral spinal cord injury.		circRNA5775 / circRNA 5775	rno_circ_Fcf1	Fcf1	suprasacral spinal cord injury / SSCI	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR; RNA-seq	"circRNA5775 is significantly up-regulated in rat bladder tissue during SSCI-induced neurogenic bladder/bladder fibrosis across multiple time points, with RNA-seq results validated by qRT-PCR. No circRNA5775-specific downstream mechanism is experimentally established beyond predicted ceRNA networks."	0.4997
37744239	PeerJ	2023	Expression profiles of circular RNAs and interaction networks of competing endogenous RNAs in neurogenic bladder of rats following suprasacral spinal cord injury.		circRNA0617 / circRNA 0617	rno_circ_Dock8	Dock8	suprasacral spinal cord injury / SSCI	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR; RNA-seq	"circRNA0617 (host gene Dock8) is up-regulated in rat bladder tissue after SSCI leading to neurogenic bladder/bladder fibrosis, validated by qRT-PCR. The study does not experimentally define its downstream targets; its role is mainly inferred within predicted circRNA_miRNA_mRNA networks."	0.4997
37744239	PeerJ	2023	Expression profiles of circular RNAs and interaction networks of competing endogenous RNAs in neurogenic bladder of rats following suprasacral spinal cord injury.		circRNA2378 / circRNA 2378	rno_circ_Diaph3	Diaph3	suprasacral spinal cord injury / SSCI	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR; RNA-seq	"circRNA2378 (host gene Diaph3) is up-regulated in rat bladder tissue after SSCI, and the authors suggest it may contribute to bladder fibrosis. Mechanistically, it is discussed in the context of TGF-beta pathway/EMT and predicted ceRNA interactions, without direct functional validation for this circRNA."	0.4997
37744239	PeerJ	2023	Expression profiles of circular RNAs and interaction networks of competing endogenous RNAs in neurogenic bladder of rats following suprasacral spinal cord injury.		circRNA0613 / circRNA 0613	rno_circ_Pgm5	Pgm5	suprasacral spinal cord injury / SSCI	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR; RNA-seq	"circRNA0613 is significantly up-regulated in rat bladder tissue during SSCI-induced neurogenic bladder/bladder fibrosis across multiple time points, validated by qRT-PCR. No circRNA0613-specific functional mechanism is established beyond predicted ceRNA network analyses."	0.4997
37744239	PeerJ	2023	Expression profiles of circular RNAs and interaction networks of competing endogenous RNAs in neurogenic bladder of rats following suprasacral spinal cord injury.		circRNA3111 / circRNA 3111	rno_circ_Ces1d	Ces1d	suprasacral spinal cord injury / SSCI	MONDO:0043797	spinal cord injury	down-regulated	RT-qPCR; RNA-seq	"circRNA3111 is significantly down-regulated in rat bladder tissue during SSCI-induced neurogenic bladder/bladder fibrosis, and its expression change is validated by qRT-PCR. The study does not provide circRNA3111-specific downstream targets or mechanisms beyond predicted ceRNA network analysis at the dataset level."	0.4997
37744239	PeerJ	2023	Expression profiles of circular RNAs and interaction networks of competing endogenous RNAs in neurogenic bladder of rats following suprasacral spinal cord injury.		circRNA0586 / circRNA 0586	rno_circ_Tle4	Tle4	suprasacral spinal cord injury / SSCI	MONDO:0043797	spinal cord injury	down-regulated	RT-qPCR; RNA-seq	"circRNA0586 (host gene Tle4) is significantly down-regulated in rat bladder tissue during SSCI-induced neurogenic bladder/bladder fibrosis, validated by qRT-PCR. The paper discusses EMT relevance in the context of the host gene, but does not experimentally validate a circRNA0586-specific functional axis."	0.4997
37744239	PeerJ	2023	Expression profiles of circular RNAs and interaction networks of competing endogenous RNAs in neurogenic bladder of rats following suprasacral spinal cord injury.		circRNA1617 / circRNA 1617	rno_circ_Adgrd1	Adgrd1	suprasacral spinal cord injury / SSCI	MONDO:0043797	spinal cord injury	down-regulated	RT-qPCR; RNA-seq	circRNA1617 is significantly down-regulated in rat bladder tissue after SSCI (neurogenic bladder/bladder fibrosis) and is among the qRT-PCR-validated DECs. The study provides no circRNA1617-specific targets or mechanism beyond predicted ceRNA network analysis.	0.4997
37744239	PeerJ	2023	Expression profiles of circular RNAs and interaction networks of competing endogenous RNAs in neurogenic bladder of rats following suprasacral spinal cord injury.		circRNA4426 / circRNA 4426	rno_circ_Itch	Itch	suprasacral spinal cord injury / SSCI	MONDO:0043797	spinal cord injury	down-regulated	RT-qPCR; RNA-seq	"circRNA4426 (host gene Itch) is significantly down-regulated in rat bladder tissue after SSCI and is qRT-PCR validated. The authors suggest it may be involved in fibrosis/inflammation in SSCI-induced neurogenic bladder, but do not experimentally establish a circRNA4426-specific miRNA/mRNA axis."	0.4997
37744277	Oncology research	2023	CircUCP2 promotes the tumor progression of non-small cell lung cancer through the miR-149/UCP2 pathway.	hsa_circ_0023525	circUCP2	hsa_circ_UCP2	UCP2	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circUCP2 (hsa_circ_0023525) is up-regulated in NSCLC tissues and cells and promotes proliferation, invasion, and metastasis. Mechanistically, it mainly localizes to the cytoplasm and acts as a ceRNA that sponges miR-149, thereby increasing UCP2 expression (circUCP2/miR-149/UCP2 axis)."	0.8397
37744330	Frontiers in immunology	2023	CircUBXN7 promotes macrophage infiltration and renal fibrosis associated with the IGF2BP2-dependent SP1 mRNA stability in diabetic kidney disease.		circUBXN7	hsa_circ_UBXN7	UBXN7	diabetic kidney disease / DKD	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR; Microarray	"circUBXN7 is up-regulated in DKD patient plasma and HG-stimulated HK-2 cells, and promotes macrophage activation/infiltration, tubular EMT, and renal fibrosis, worsening DKD phenotypes in db/db mice. Mechanistically, it binds IGF2BP2 to enhance SP1 mRNA stability and forms a positive feedback loop where SP1 transcriptionally increases circUBXN7."	0.8133
37745562	bioRxiv : the preprint server for biology	2024	circHIPK3 nucleates IGF2BP2 and functions as a competing endogenous RNA.		CircHIPK3	hsa_circ_HIPK3	HIPK3	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	dysregulated	RT-qPCR; RNA-seq	"In bladder cancer models, circHIPK3 binds IGF2BP2 through an 11-mer motif and modulates IGF2BP2 engagement with target mRNAs (e.g., STAT3), consistent with an RBP-focused ceRNA-like mechanism affecting mRNA stability. circHIPK3 overexpression promotes formation of IGF2BP2 condensates, suggesting a nucleation/phase-separation component. Clinically, higher circHIPK3 levels are associated with better overall survival in NMIBC cohorts."	0.8397
37752765	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2023	EGCG-LYS Fibrils-Mediated CircMAP2K2 Silencing Decreases the Proliferation and Metastasis Ability of Gastric Cancer Cells in Vitro and in Vivo.	hsa_circ_0007376	circMAP2K2 / hsa_circRNA_102415	hsa_circ_MAP2K2	MAP2K2	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circMAP2K2 (hsa_circ_0007376) is up-regulated in gastric cancer cell lines and promotes proliferation and metastasis-related behaviors. Mechanistically, it binds PCBP1 in the cytoplasm and facilitates proteasome-mediated reduction of PCBP1, affecting GPX1 and activating AKT/GSK3beta signaling to drive an EMT-like phenotype; EIF4A3 contributes to its upregulation/biogenesis."	0.8095
37752955	iScience	2023	circELMOD3 increases and stabilizes TRIM13 by sponging miR-6864-5p and direct binding to inhibit HCC progression.	hsa_circ_0004726	circELMOD3	hsa_circ_ELMOD3	ELMOD3	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"circELMOD3 is down-regulated in HCC tissues and plasma and functions as a tumor suppressor. It sponges miR-6864-5p to increase TRIM13 and also directly binds TRIM13 mRNA to enhance its stability, thereby activating p53 signaling to inhibit HCC progression."	0.8836
37759884	Brain sciences	2023	Transcriptome-Wide Analysis of Neutrophil-Related Circ_22232 in Neuroinflammation from Ischemic Stroke Mice.		circ_22232	mmu_circ_Specc1l	Specc1l	ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; RNA-seq	"In MCAO ischemic-stroke mice, circ_22232 (Specc1l) is up-regulated in brain tissue and is associated with neutrophil-related neuroinflammation. Knockdown of circ_22232 reduces neutrophil activation, decreases proinflammatory cytokines, increases anti-inflammatory cytokines, and alleviates ischemic brain injury, potentially via the circRNA_22232/miR-874-3p/Bmp1 axis."	0.6046
37762282	International journal of molecular sciences	2023	Vesicular Release and Uptake of Circular LSD1-RNAs from Non-Cancer and Cancer Lung Cells.	hsa_circ_0009061	circ 3_2_2a / circLSD1 3_2_2a	hsa_circ_KDM1A	KDM1A	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	unknown	RT-qPCR	"This circLSD1 RNA (from KDM1A) is mainly cytoplasmic and can be exported into the extracellular space, with cancer cells packaging it in EVs while non-cancer cells release it in RNP-protected forms. Extracellular circLSD1 RNAs can be taken up by recipient lung cells, supporting a role in intercellular communication in the lung cancer microenvironment."	0.6091
37762282	International journal of molecular sciences	2023	Vesicular Release and Uptake of Circular LSD1-RNAs from Non-Cancer and Cancer Lung Cells.		circ 3_2 / circLSD1-3_2	hsa_circ_KDM1A	KDM1A	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR	"circ 3_2 (a KDM1A-derived circLSD1 RNA) is down-regulated in LUAD tumor tissues versus matched non-tumor tissues. It is also detectable as extracellular RNA and can be transferred between lung cancer and non-cancer epithelial cells, consistent with a role in EV/RNP-mediated intercellular communication."	0.5909
37762282	International journal of molecular sciences	2023	Vesicular Release and Uptake of Circular LSD1-RNAs from Non-Cancer and Cancer Lung Cells.	hsa_circ_0112434	circ 2a_2 / circ_0112434	hsa_circ_KDM1A	KDM1A	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	unknown	RT-qPCR	"hsa_circ_0112434 (circ 2a_2) is a KDM1A-derived circRNA that is mainly cytoplasmic, can be released extracellularly (EV/RNP-associated), and is efficiently taken up by recipient lung cells. It is also detectable in serum from T-PLL patients but not healthy donors, supporting its presence as a circulating extracellular RNA."	0.695
37762282	International journal of molecular sciences	2023	Vesicular Release and Uptake of Circular LSD1-RNAs from Non-Cancer and Cancer Lung Cells.		circ 2	hsa_circ_KDM1A	KDM1A	T-cell prolymphocytic leukemia / T-PLL	MONDO:0019468	T-cell prolymphocytic leukemia	up-regulated	RT-qPCR	"circ 2 (a KDM1A-derived circLSD1 RNA) is detectable in serum from T-PLL patients but absent in healthy donor serum, indicating it can circulate as an extracellular RNA in a cancer context. The study does not define downstream molecular targets for circ 2."	0.3544
37766977	iScience	2023	CircSOBP suppresses the progression of glioma by disrupting glycolysis and promoting the MDA5-mediated immune response.	hsa_circ_0001633	circSOBP	hsa_circ_SOBP	SOBP	glioma	MONDO:0021042	glioma	down-regulated	RT-qPCR; Northern Blot; RNA-seq	"circSOBP is down-regulated in glioma tissues, glioma cell lines, and patient serum. It suppresses glioma proliferation/migration/invasion and glycolysis by binding TKFC, lowering TKFC protein and disrupting TKFC_MDA5 interaction to activate the IKKepsilon/TBK1/IRF3_IFN-I immune signaling, enhancing CD8+ T and NK antitumor responses in vivo."	0.8941
37772397	Molecular medicine reports	2023	circ_0000018 downregulation peripherally ameliorates neuroprotection against acute ischemic stroke through the miR_871/BCL2L11 axis.	mmu_circ_0000018	circ_0000018			ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR	circ_0000018 is up-regulated in OGD/R-treated neuronal cells and in tMCAO mouse brains. It aggravates ischemia/reperfusion-related neuronal injury by sponging miR-871 and thereby increasing BCL2L11; circ_0000018 knockdown reduces apoptosis and improves infarct-related outcomes.	0.7213
37773733	Cancer biology & therapy	2023	Hsa_circ_0119412 is a tumor promoter in hepatocellular carcinoma by inhibiting miR-526b-5p to upregulate STMN1.	hsa_circ_0119412		hsa_circ_PER2	PER2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"hsa_circ_0119412 is upregulated in hepatocellular carcinoma and mainly localizes in the cytoplasm. It promotes HCC cell proliferation and migration and inhibits apoptosis, partly by sponging miR-526b-5p to upregulate STMN1, and it enhances tumor growth in a cell line-derived xenograft model."	0.7785
37780378	PeerJ	2023	Berberine protects hepatocyte from hypoxia/reoxygenation-induced injury through inhibiting circDNTTIP2.	hsa_circ_0013218	circDNTTIP2 / circ_0013218	hsa_circ_DNTTIP2	DNTTIP2	hepatic ischemia-reperfusion injury	MONDO:0005154	liver disorder	up-regulated	RT-qPCR; Microarray	"circDNTTIP2 is up-regulated in H/R-injured L02 hepatocytes and promotes injury phenotypes including apoptosis, ROS production, and pro-inflammatory cytokine release. Mechanistically, circDNTTIP2 enhances caspase3 transcription by binding the TATA box region of the caspase3 promoter, and berberine mitigates H/R injury partly by inhibiting circDNTTIP2."	0.6865
37780544	Oncology letters	2023	Association between circ_0004365 and cisplatin resistance in esophageal squamous cell carcinoma.	hsa_circ_0004365	circ_0004365	hsa_circ_SEMA3C	SEMA3C	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ_0004365 (hsa_circ_0004365), derived from SEMA3C, is upregulated in cisplatin-resistant ESCC cell lines and in ESCC tumors after NAC. Its knockdown increases cisplatin sensitivity in vitro, and bioinformatic/RT-PCR evidence suggests it may act through a ceRNA network involving miR-503 and downstream targets/pathways (including Hippo pathway enrichment)."	0.5495
37780548	Oncology letters	2023	High hsa_circ_0081621 expression indicates a poor prognosis of laryngeal squamous cell carcinoma: A bioinformatics analysis and retrospective clinical study.	hsa_circ_0081621				laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"hsa_circ_0081621 is up-regulated in LSCC tissues and is mainly localized in the cytoplasm. High hsa_circ_0081621 expression correlates with lymph node metastasis, higher clinical stage, and poorer overall survival, serving as an independent prognostic factor in LSCC; no molecular mechanism was experimentally explored in this study."	0.5267
37780548	Oncology letters	2023	High hsa_circ_0081621 expression indicates a poor prognosis of laryngeal squamous cell carcinoma: A bioinformatics analysis and retrospective clinical study.	hsa_circ_0015211				laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circ_0015211 was identified from GSE117001 as one of the top upregulated circRNAs in LSCC and was validated as upregulated by RT-qPCR in 10 paired LSCC vs adjacent non-carcinoma tissues; no functional/mechanistic or prognostic analyses were reported for this circRNA.	0.4032
37780548	Oncology letters	2023	High hsa_circ_0081621 expression indicates a poor prognosis of laryngeal squamous cell carcinoma: A bioinformatics analysis and retrospective clinical study.	hsa_circ_0023326				laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circ_0023326 was identified from GSE117001 as one of the top upregulated circRNAs in LSCC and was validated as upregulated by RT-qPCR in 10 paired LSCC vs adjacent non-carcinoma tissues; no functional/mechanistic or prognostic analyses were reported for this circRNA.	0.4032
37781045	International journal of biological sciences	2023	cDCBLD2 mediates sorafenib resistance in hepatocellular carcinoma by sponging miR-345-5p binding to the TOP2A coding sequence.	hsa_circ_0066631	circRNA_103420 / cDCBLD2	hsa_circ_DCBLD2	DCBLD2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"cDCBLD2 (circRNA_103420 / hsa_circ_0066631) is upregulated in sorafenib-resistant HCC cells and promotes resistance by enhancing proliferation and inhibiting apoptosis. Mechanistically, it sponges miR-345-5p to stabilize TOP2A mRNA (via CDS-binding miRNA regulation), increasing TOP2A and dampening caspase-3-mediated apoptosis; cDCBLD2 knockdown sensitizes tumors to sorafenib in a PDX model."	0.7796
37781863	European journal of histochemistry : EJH	2023	Overexpression of hsa_circ_0001861 inhibits pulmonary fibrosis through targeting miR-296-5p/BCL-2 binding component 3 axis.	hsa_circ_0001861	hsa_circRNA_0001861			pulmonary fibrosis / lung fibrosis	MONDO:0002771	pulmonary fibrosis	down-regulated	RT-qPCR	"hsa_circ_0001861 is reduced in TGF-beta-treated pulmonary fibroblasts, and its overexpression suppresses fibroblast proliferation/migration and fibrotic marker expression while promoting apoptosis. Mechanistically, it sponges miR-296-5p to de-repress BBC3, and it alleviates bleomycin-induced pulmonary fibrosis in mice via the miR-296-5p/BBC3 axis."	0.7052
37782276	Renal failure	2023	CircRNA itchy E3 ubiquitin protein ligase improves mitochondrial dysfunction in sepsis-induced acute kidney injury by targeting microRNA-214-3p/ATP-binding cassette A1 axis.		circRNA itchy E3 ubiquitin protein ligase / circ-ITCH	hsa_circ_ITCH	ITCH	sepsis-induced acute kidney injury	MONDO:0002492	acute kidney injury	down-regulated	RT-qPCR	"circ-ITCH is downregulated in LPS-induced sepsis-AKI models and its overexpression alleviates kidney injury by reducing apoptosis, oxidative stress, inflammation, and mitochondrial dysfunction. Mechanistically, circ-ITCH sponges miR-214-3p to relieve repression of ABCA1, forming a circ-ITCH/miR-214-3p/ABCA1 regulatory axis."	0.5709
37782276	Renal failure	2023	CircRNA itchy E3 ubiquitin protein ligase improves mitochondrial dysfunction in sepsis-induced acute kidney injury by targeting microRNA-214-3p/ATP-binding cassette A1 axis.		circRNA itchy E3 ubiquitin protein ligase / circ-ITCH	mmu_circ_ITCH	ITCH	sepsis-induced acute kidney injury	MONDO:0002492	acute kidney injury	down-regulated	RT-qPCR	"circ-ITCH is downregulated in LPS-induced sepsis-AKI models and its overexpression alleviates kidney injury by reducing apoptosis, oxidative stress, inflammation, and mitochondrial dysfunction. Mechanistically, circ-ITCH sponges miR-214-3p to relieve repression of ABCA1, forming a circ-ITCH/miR-214-3p/ABCA1 regulatory axis."	0.5709
37783059	Redox biology	2023	The novel beta-TrCP protein isoform hidden in circular RNA confers trastuzumab resistance in HER2-positive breast cancer.		circ-beta-TrCP	hsa_circ_BTRC	beta-TrCP	HER2-positive breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	"circ-beta-TrCP is upregulated in trastuzumab-resistant HER2-positive breast cancer tissues and plasma and promotes trastuzumab resistance in vitro and in vivo. It functions mainly via encoding the peptide beta-TrCP-343aa, whose translation is inhibited by eIF3j, and which stabilizes NRF2 by competitively blocking SCFbeta-TrCP-mediated NRF2 degradation, enhancing NRF2-driven antioxidant programs and forming a positive feedback loop (NRF2 represses eIF3j) that accelerates resistance."	0.9031
37789644	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2023	A Novel Trojan Horse Nanotherapy Strategy Targeting the cPKM-STMN1/TGFB1 Axis for Effective Treatment of Intrahepatic Cholangiocarcinoma.	hsa_circ_0036200	cPKM	hsa_circ_PKM	PKM	intrahepatic cholangiocarcinoma / ICC	MONDO:0003210	intrahepatic cholangiocarcinoma	up-regulated	RT-qPCR; ISH; Microarray	"cPKM (hsa_circ_0036200) is up-regulated in intrahepatic cholangiocarcinoma and high cPKM predicts poor prognosis. Functionally, cPKM promotes ICC proliferation/metastasis, activates HSCs to drive stromal fibrosis, and increases paclitaxel resistance by sponging miR-199a-5p to upregulate STMN1 and by binding IGF2BP2 to stabilize STMN1/TGFB1 mRNAs, leading to enhanced AKT signaling and TGFB1 secretion."	0.8912
37794386	Cancer cell international	2023	Hsa_circRNA_102051 regulates colorectal cancer proliferation and metastasis by mediating Notch pathway.		hsa_circRNA_102051 / hsa_circ_102051	hsa_circ_TADA2A	TADA2A	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_102051 (TADA2A-derived) is up-regulated in colorectal cancer, particularly metastatic samples, and mainly localizes to the cytoplasm. It promotes proliferation, invasion/migration, stemness, and in vivo tumor growth/metastasis by sponging miR-203a to increase BPTF and activate Notch signaling."	0.8541
37794449	Journal of nanobiotechnology	2023	Exosome-derived circ_0001785 delays atherogenesis through the ceRNA network mechanism of miR-513a-5p/TGFBR3.	hsa_circ_0001785	circ_0001785	hsa_circ_ELP3	ELP3	atherosclerosis / AS	MONDO:0005311	atherosclerosis	dysregulated	RT-qPCR	"Exosome-derived circ_0001785 is dysregulated in CHD/atherosclerosis (reduced in circulating blood/leukocytes but increased in plaque tissue). Functionally, circ_0001785 protects endothelial cells and delays atherogenesis by acting as a ceRNA that sponges miR-513a-5p, thereby upregulating TGFBR3 to promote proliferation and inhibit apoptosis/migration and intraplaque neovascularization."	0.8166
37805546	Scientific reports	2023	Differentially expressed circRNAs in peripheral blood samples as potential biomarkers and therapeutic targets for acute angle-closure glaucoma.	hsa_circ_0135571		hsa_circ_NEAT1	NEAT1	primary angle-closure glaucoma	MONDO:0001868	primary angle-closure glaucoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0135571 is upregulated in peripheral blood from glaucoma patients and is proposed to act as a miRNA sponge (e.g., hsa-miR-4775) to increase NEAT1 expression, potentially contributing to immune-related mechanisms in glaucoma."	0.4032
37805546	Scientific reports	2023	Differentially expressed circRNAs in peripheral blood samples as potential biomarkers and therapeutic targets for acute angle-closure glaucoma.	hsa_circ_0000745				primary angle-closure glaucoma	MONDO:0001868	primary angle-closure glaucoma	unknown	RT-qPCR	hsa_circ_0000745 is implicated in glaucoma via a predicted circRNA_miRNA_mRNA network and was RT-qPCR-verified to correlate positively with NEAT1 expression. It may regulate NEAT1 through hsa-miR-4659a-3p and hsa-miR-6873-3p and is proposed as a blood biomarker for early glaucoma diagnosis.	0.348
37809396	Heliyon	2023	Hsa_circ_0043603 promotes the progression of esophageal squamous cell carcinoma by sponging miR-1178-3p and regulating AADAC expression.	hsa_circ_0043603		hsa_circ_KRT19	KRT19	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	RT-qPCR; ISH	"hsa_circ_0043,603 is down-regulated in ESCC and functions as a tumor suppressor. It predominantly localizes in the cytoplasm and inhibits ESCC cell proliferation, migration, invasion and in vivo tumor growth while promoting apoptosis, mainly by sponging miR-1178_3p to relieve repression of AADAC. Low hsa_circ_0043,603 expression is associated with worse prognosis, supporting its potential as a biomarker and therapeutic target."	0.8658
37810197	Disease markers	2023	hsa_circ_0129047 Upregulates LYVE1 to Inhibit Hepatocellular Carcinoma Progression by Sponging miR-492.	hsa_circ_0129047	circ_0129047 / circ_012904	hsa_circ_LIFR	LIFR	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"circ_0129047 is down-regulated in hepatocellular carcinoma tissues and cell lines and functions as a tumor suppressor. It mainly localizes to the cytoplasm and inhibits HCC proliferation, migration, invasion, and xenograft growth by sponging miR-492 to de-repress LYVE1 (circ_0129047/miR-492/LYVE1 axis)."	0.7795
37810854	Heliyon	2023	Circular RNA circWHSC1 facilitates colorectal cancer cell proliferation by targeting miR-130a-5p/zeb1 signaling in vitro and in vivo.		circWHSC1	hsa_circ_WHSC1	WHSC1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circWHSC1 is up-regulated in colorectal cancer cell lines and predominantly localizes to the cytoplasm. It promotes CRC cell proliferation, migration/invasion and tumor growth by sponging miR-130a-5p and thereby increasing zeb1 expression; miR-130a-5p inhibition or zeb1 overexpression rescues circWHSC1-knockdown phenotypes."	0.7801
37814902	Thoracic cancer	2023	Circ_MACF1 targets miR-421 to upregulate FMO2 to suppress paclitaxel resistance and malignant cellular behaviors in lung adenocarcinoma.	hsa_circ_0011780	circ_MACF1	hsa_circ_MACF1	MACF1	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR	"circ_MACF1 is down-regulated in paclitaxel-resistant lung adenocarcinoma and functions as a tumor-suppressive, chemosensitizing circRNA. It sponges miR-421 to relieve repression of FMO2, thereby reducing PTX resistance and inhibiting proliferation/motility while promoting apoptosis, including in a cell line-derived xenograft model."	0.7183
37815664	International urology and nephrology	2024	"Urinary stem cell-derived exocrine circRNA ATG7 regulates the SOCS1/STAT3 signaling pathway through miR-4500, inhibits M1 macrophage polarization, and alleviates the progression of diabetes nephropathy."	hsa_circ_0064288	circRNA ATG7 / circ_0064288	hsa_circ_ATG7	ATG7	diabetic nephropathy / DN	MONDO:0005016	diabetic kidney disease	down-regulated	RT-qPCR	"In a streptozotocin-induced DN rat model, exosomal circRNA ATG7 derived from urinary stem cells is down-regulated, and restoring/overexpressing it alleviates renal injury. Mechanistically, circRNA ATG7 targets miR-4500 to modulate the SOCS1/STAT3 signaling pathway, suppressing M1 polarization and promoting M2 macrophage polarization, thereby reducing inflammation in DN."	0.528
37816766	"Schizophrenia (Heidelberg, Germany)"	2023	Comprehensive analysis of circRNA expression profile and circRNA-miRNA-mRNA network susceptibility to very early-onset schizophrenia.	hsa_circ_0005035		hsa_circ_IGF1R	IGF1R	very early-onset schizophrenia / VEOS	MONDO:0019939	early-onset schizophrenia	down-regulated	RNA-seq	hsa_circ_0005035 is down-regulated in plasma from VEOS patients and is derived from the host gene IGF1R. It is included in the predicted circRNA-miRNA regulatory network and is targeted by has-miR-16-5p.	0.1768
37816766	"Schizophrenia (Heidelberg, Germany)"	2023	Comprehensive analysis of circRNA expression profile and circRNA-miRNA-mRNA network susceptibility to very early-onset schizophrenia.	hsa_circ_0000638				very early-onset schizophrenia / VEOS	MONDO:0019939	early-onset schizophrenia	unknown	RNA-seq	"hsa_circ_0000638 is implicated as a predicted target of has-miR-16-5p in the VEOS circRNA-miRNA interaction network, suggesting a potential ceRNA-related role in VEOS plasma."	0.1768
37816766	"Schizophrenia (Heidelberg, Germany)"	2023	Comprehensive analysis of circRNA expression profile and circRNA-miRNA-mRNA network susceptibility to very early-onset schizophrenia.	hsa_circ_0001200				very early-onset schizophrenia / VEOS	MONDO:0019939	early-onset schizophrenia	unknown	RNA-seq	"hsa_circ_0001200 is included as a predicted has-miR-16-5p-interacting circRNA in the VEOS circRNA-miRNA network, suggesting a possible ceRNA-related regulatory role in VEOS."	0.1768
37816766	"Schizophrenia (Heidelberg, Germany)"	2023	Comprehensive analysis of circRNA expression profile and circRNA-miRNA-mRNA network susceptibility to very early-onset schizophrenia.	hsa_circ_0001789				very early-onset schizophrenia / VEOS	MONDO:0019939	early-onset schizophrenia	unknown	RNA-seq	"hsa_circ_0001789 is included as a predicted has-miR-16-5p-interacting circRNA in the VEOS circRNA-miRNA network, suggesting a possible ceRNA-related regulatory role in VEOS."	0.1768
37816766	"Schizophrenia (Heidelberg, Germany)"	2023	Comprehensive analysis of circRNA expression profile and circRNA-miRNA-mRNA network susceptibility to very early-onset schizophrenia.	hsa_circ_0007762		hsa_circ_STXBP5	STXBP5	very early-onset schizophrenia / VEOS	MONDO:0019939	early-onset schizophrenia	unknown	RNA-seq	"hsa_circ_0007762 is mentioned as a VEOS candidate circRNA whose host gene is STXBP5, which is involved in synaptic vesicle docking and fusion; however, its specific regulatory mechanism in this study is not detailed."	0.1155
37819813	Aging	2023	Targeting circular RNA-Glra2 alleviates retinal neurodegeneration induced by ocular hypertension.	hsa_circ_0139862	cGlra2 / circular RNA-Glra2	hsa_circ_GLRA2	Glra2	glaucoma	MONDO:0005041	glaucoma	up-regulated	RT-qPCR; ISH; Microarray	"cGlra2 is up-regulated in ocular-hypertension retinas and in glaucoma patient aqueous humor and shows diagnostic potential. Functionally, cGlra2 promotes RGC injury/apoptosis and retinal neurodegeneration; its silencing is protective in vitro and in vivo. Mechanistically, cGlra2 acts as a ceRNA that sponges miR-144 to derepress BCL2L11, contributing to RGC apoptosis."	0.7674
37819813	Aging	2023	Targeting circular RNA-Glra2 alleviates retinal neurodegeneration induced by ocular hypertension.	mmu_circ_0016226	cGlra2 / circular RNA-Glra2	mmu_circ_Glra2	Glra2	glaucoma	MONDO:0005041	glaucoma	up-regulated	RT-qPCR; ISH; Microarray	"cGlra2 is up-regulated in ocular-hypertension retinas and in glaucoma patient aqueous humor and shows diagnostic potential. Functionally, cGlra2 promotes RGC injury/apoptosis and retinal neurodegeneration; its silencing is protective in vitro and in vivo. Mechanistically, cGlra2 acts as a ceRNA that sponges miR-144 to derepress BCL2L11, contributing to RGC apoptosis."	0.7674
37819813	Aging	2023	Targeting circular RNA-Glra2 alleviates retinal neurodegeneration induced by ocular hypertension.	mmu_circ_0016224				ocular hypertension	MONDO:0006875	ocular hypertension	up-regulated	RT-qPCR; Microarray	"mmu_circ_0016224 was identified by circRNA microarray as up-regulated in microbeads-induced ocular-hypertension retinas, and this change was confirmed by RT-qPCR. No downstream mechanism or functional experiments were reported for mmu_circ_0016224."	0.3588
37819813	Aging	2023	Targeting circular RNA-Glra2 alleviates retinal neurodegeneration induced by ocular hypertension.		cicRNA.16113			ocular hypertension	MONDO:0006875	ocular hypertension	up-regulated	RT-qPCR; Microarray	"cicRNA.16113 was identified as up-regulated in ocular-hypertension retinas by microarray and validated by RT-qPCR, but the study did not further characterize its mechanism or function."	0.3588
37819813	Aging	2023	Targeting circular RNA-Glra2 alleviates retinal neurodegeneration induced by ocular hypertension.		cicRNA.7215			ocular hypertension	MONDO:0006875	ocular hypertension	down-regulated	RT-qPCR; Microarray	cicRNA.7215 was found down-regulated in ocular-hypertension retinas in the microarray screen and confirmed by RT-qPCR; no mechanistic/functional analyses were performed for this circRNA.	0.3588
37819813	Aging	2023	Targeting circular RNA-Glra2 alleviates retinal neurodegeneration induced by ocular hypertension.		cicRNA.27992			ocular hypertension	MONDO:0006875	ocular hypertension	down-regulated	RT-qPCR; Microarray	cicRNA.27992 was down-regulated in ocular-hypertension retinas and its differential expression was confirmed by RT-qPCR; no additional functional or mechanistic data were provided.	0.3588
37819813	Aging	2023	Targeting circular RNA-Glra2 alleviates retinal neurodegeneration induced by ocular hypertension.	mmu_circ_0016436				ocular hypertension	MONDO:0006875	ocular hypertension	down-regulated	RT-qPCR; Microarray	mmu_circ_0016436 was down-regulated in ocular-hypertension retinas and validated by RT-qPCR; the article did not provide functional or mechanistic characterization for this circRNA.	0.3588
37821382	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2023	m6A-Modified circTET2 Interacting with HNRNPC Regulates Fatty Acid Oxidation to Promote the Proliferation of Chronic Lymphocytic Leukemia.		circTET2	hsa_circ_TET2	TET2	chronic lymphocytic leukemia / CLL	MONDO:0003864	chronic lymphocytic leukemia/small lymphocytic lymphoma	up-regulated	RT-qPCR; Northern Blot; RNA-seq	"circTET2 is up-regulated in CLL and high expression predicts poorer overall survival and has diagnostic potential. Mechanistically, m6A modification influences its nuclear export, and cytoplasmic circTET2 binds HNRNPC to increase CPT1A mRNA stability, activating mTORC1 signaling and enhancing fatty acid oxidation to promote CLL cell proliferation."	0.8921
37829805	Heliyon	2023	CircUSP10 promotes liver cancer progression by regulating miR-211-5p/TCF12/EMT signaling pathway.		circUSP10 / hsa_circRNA_101889	hsa_circ_USP10	USP10	liver cancer	MONDO:0002691	liver cancer	up-regulated	RT-qPCR; Microarray	"circUSP10 is upregulated in liver cancer and promotes proliferation, migration, invasion, and tumor growth. It mainly localizes to the cytoplasm and acts as a ceRNA by sponging miR-211-5p, thereby upregulating TCF12 and activating EMT-associated changes. High circUSP10 expression correlates with advanced clinicopathological features and poorer overall survival."	0.8769
37831180	Cellular and molecular life sciences : CMLS	2023	Silencing circSERPINE2 restrains mesenchymal stem cell senescence via the YBX3/PCNA/p21 axis.	hsa_circ_0005773	circSERPINE2	hsa_circ_SERPINE2	SERPINE2	aging			up-regulated	RT-qPCR; RNA-seq	"circSERPINE2 (hsa_circ_0005773) is up-regulated during MSC senescence and in OA patient synovium. It promotes MSC senescence by binding YBX3 and facilitating its cytoplasmic retention via ZO-1, which suppresses PCNA transcription and reduces PCNA-dependent ubiquitin_proteasome degradation of p21. In aged mice, intra-articular si-circSerpine2 alleviates joint-resident MSC senescence and cartilage degeneration in aging-related OA."	0.8637
37831180	Cellular and molecular life sciences : CMLS	2023	Silencing circSERPINE2 restrains mesenchymal stem cell senescence via the YBX3/PCNA/p21 axis.		circSerpine2	mmu_circ_Serpine2	Serpine2	senescence			up-regulated	RT-qPCR	"Mouse circSerpine2 accumulates in aged joints (notably in synovial Sca-1+ MSCs) and contributes to aging-related OA phenotypes. Intra-articular si-circSerpine2 reduces MSC senescence (lower p21 in Sca-1+ MSCs), increases PCNA, and improves OA-related joint outcomes (reduced cartilage degradation and osteophyte formation)."	0.5627
37833621	BMC cancer	2023	Circular RNA CCT3 is a unique molecular marker in bladder cancer.	hsa_circ_0004680	circRNA CCT3 / circ_0004680	hsa_circ_CCT3	CCT3	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"circRNA CCT3 (hsa_circ_0004680, from host gene CCT3) is up-regulated in bladder cancer patient samples and is associated with poor survival. Functionally, it promotes malignant behaviors of BCa cells and inhibits apoptosis. Mechanistically, it sponges miR-135a-5p to increase PP2A expression, forming a circRNA CCT3/miR-135a-5p/PP2A regulatory axis with diagnostic and prognostic relevance."	0.8486
37837352	Journal of cellular and molecular medicine	2023	CircularRNA Hsa_circ_0093335 promotes hepatocellular carcinoma progression via sponging miR-338-5p.	hsa_circ_0093335	circ0093335	hsa_circ_BMI1	BMI1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	circ0093335 is up-regulated in hepatocellular carcinoma tissues and cell lines and promotes tumor growth and aggressive phenotypes. It mainly localizes in the cytoplasm and accelerates HCC progression by sponging miR-338-5p.	0.8228
37838643	Journal of cancer research and clinical oncology	2023	METTL3-mediated m6A modification of circRNF220 modulates miR-330-5p/survivin axis to promote osteosarcoma progression.	hsa_circ_0000066	circRNF220	hsa_circ_RNF220	RNF220	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"circRNF220 is up-regulated in osteosarcoma tissues and cell lines and promotes proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, METTL3-mediated m6A modification increases circRNF220, which sponges miR-330-5p to upregulate survivin."	0.8817
37841466	Frontiers in veterinary science	2023	Circular RNAs are associated with the resistance to Newcastle disease virus infection in duck cells.		novel_circ_000094		FBXW7	Newcastle disease / NDV infection	MONDO:0005875	Newcastle disease	up-regulated	RT-qPCR; RNA-seq	"In NDV-infected duck embryo fibroblast cells, circ-FBXW7 (novel_circ_000094) is up-regulated and enhances antiviral resistance. Functional assays show that circ-FBXW7 overexpression suppresses, while knockdown promotes, NDV replication. Mechanistically, circ-FBXW7 is predicted to sponge mir-338-y and thereby influence downstream mRNAs enriched in cell-cycle/senescence pathways."	0.7062
37841466	Frontiers in veterinary science	2023	Circular RNAs are associated with the resistance to Newcastle disease virus infection in duck cells.		novel_circ_000912		CUL1	Newcastle disease / NDV infection	MONDO:0005875	Newcastle disease	up-regulated	RT-qPCR; RNA-seq	"novel_circ_000912 (host gene CUL1) is up-regulated in NDV-infected duck embryo fibroblast cells and was experimentally validated as a bona fide circRNA (divergent PCR, Sanger sequencing, RNase R, RT-qPCR). The study does not report a specific downstream mechanism or functional antiviral assays for this circRNA."	0.4566
37841466	Frontiers in veterinary science	2023	Circular RNAs are associated with the resistance to Newcastle disease virus infection in duck cells.		novel_circ_001672		NLK	Newcastle disease / NDV infection	MONDO:0005875	Newcastle disease	up-regulated	RT-qPCR; RNA-seq	"novel_circ_001672 (host gene NLK) is up-regulated in NDV-infected duck embryo fibroblast cells and was validated as a true circRNA by divergent PCR, Sanger sequencing, RNase R digestion, and RT-qPCR consistent with sequencing. No dedicated downstream targets or functional assays were reported for this circRNA."	0.4566
37841466	Frontiers in veterinary science	2023	Circular RNAs are associated with the resistance to Newcastle disease virus infection in duck cells.		novel_circ_000991		BRF1	Newcastle disease / NDV infection	MONDO:0005875	Newcastle disease	down-regulated	RT-qPCR; RNA-seq	"novel_circ_000991 (host gene BRF1) is down-regulated in NDV-infected duck embryo fibroblast cells and was validated as a true circRNA by divergent PCR, Sanger sequencing, RNase R digestion, and RT-qPCR consistent with sequencing. The study does not report a specific functional role or mechanism for this circRNA in NDV infection."	0.4566
37841466	Frontiers in veterinary science	2023	Circular RNAs are associated with the resistance to Newcastle disease virus infection in duck cells.		novel_circ_000030		ETNK1	Newcastle disease / NDV infection	MONDO:0005875	Newcastle disease	down-regulated	RT-qPCR; RNA-seq	"novel_circ_000030 (host gene ETNK1) is down-regulated in NDV-infected duck embryo fibroblast cells and was validated as a true circRNA by divergent PCR, Sanger sequencing, RNase R digestion, and RT-qPCR consistent with sequencing. The study does not provide functional experiments or a specific regulatory mechanism for this circRNA in NDV infection."	0.4566
37841912	Frontiers in pharmacology	2023	Transcriptome-wide analysis of trigeminal ganglion and subnucleus caudalis in a mouse model of chronic constriction injury-induced trigeminal neuralgia.		Cacna2dl	mmu_circ_Cacna2d1	Cacna2d1	trigeminal neuropathic pain / TNP / trigeminal neuralgia	MONDO:0008599	trigeminal neuralgia	dysregulated	RT-qPCR; RNA-seq	"In the IoN-CCI mouse model of trigeminal neuropathic pain, the circRNA Cacna2d1 (also written as Cacna2dl) was identified as differentially expressed in trigeminal ganglion and its RNA-seq change was validated by RT-qPCR. The study did not report a specific downstream miRNA/mRNA axis or functional mechanism for this circRNA."	0.5297
37841912	Frontiers in pharmacology	2023	Transcriptome-wide analysis of trigeminal ganglion and subnucleus caudalis in a mouse model of chronic constriction injury-induced trigeminal neuralgia.		Ranbp9	mmu_circ_Ranbp9	Ranbp9	trigeminal neuropathic pain / TNP / trigeminal neuralgia	MONDO:0008599	trigeminal neuralgia	dysregulated	RT-qPCR; RNA-seq	"In the IoN-CCI mouse model of trigeminal neuropathic pain, circRNA Ranbp9 was reported as differentially expressed in trigeminal ganglion and validated by RT-qPCR in a selected set of RNAs. No specific miRNA interactions or mechanistic axis was provided for Ranbp9."	0.4062
37841912	Frontiers in pharmacology	2023	Transcriptome-wide analysis of trigeminal ganglion and subnucleus caudalis in a mouse model of chronic constriction injury-induced trigeminal neuralgia.		Map3k2	mmu_circ_Map3k2	Map3k2	trigeminal neuropathic pain / TNP / trigeminal neuralgia	MONDO:0008599	trigeminal neuralgia	dysregulated	RT-qPCR; RNA-seq	"In the IoN-CCI mouse model of trigeminal neuropathic pain, circRNA Map3k2 was identified as differentially expressed in Sp5C and its RNA-seq result was supported by RT-qPCR validation in the selected panel. The article did not provide a specific ceRNA axis or functional mechanism for Map3k2."	0.4062
37841912	Frontiers in pharmacology	2023	Transcriptome-wide analysis of trigeminal ganglion and subnucleus caudalis in a mouse model of chronic constriction injury-induced trigeminal neuralgia.		Cdh4	mmu_circ_Cdh4	Cdh4	trigeminal neuropathic pain / TNP / trigeminal neuralgia	MONDO:0008599	trigeminal neuralgia	dysregulated	RT-qPCR; RNA-seq	"In the IoN-CCI mouse model of trigeminal neuropathic pain, circRNA Cdh4 was identified as differentially expressed in Sp5C and validated by RT-qPCR in the selected RNA panel. The study did not describe a specific downstream miRNA/mRNA target or mechanism for Cdh4."	0.4062
37844011	Cancer biology & therapy	2023	Dysregulation of the circ_0087502/miR-1179/TGFBR2 pathway supports gemcitabine resistance in pancreatic cancer.	hsa_circ_0087502	circ_0087502	hsa_circ_IARS	IARS	pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"circ_0087502 is up-regulated in pancreatic cancer tissues/cell lines and is mainly cytoplasmic. It promotes proliferation, migration, invasion and gemcitabine resistance by sponging miR-1179 and de-repressing TGFBR2 (circ_0087502/miR-1179/TGFBR2 ceRNA axis), and high expression is associated with shorter overall survival."	0.8439
37848864	BMC genomics	2023	Identification and characterization of differentially expressed circular RNAs in extraocular muscle of oculomotor nerve palsy.		circRNA_03628	hsa_circ_RBFOX1	RBFOX1	oculomotor nerve palsy / ONP	MONDO:0001309	oculomotor nerve paralysis	up-regulated	RT-qPCR; RNA-seq	"circRNA_03628 (host gene RBFOX1) is up-regulated in medial rectus muscle from ONP patients versus CXT controls. It is predicted to localize mainly in the cytoplasm and to interact with hsa-miR-188-5p/hsa-miR-4529-5p and RBPs (AGO2, EIF4A3), and shows diagnostic potential for ONP (ROC AUC 0.87)."	0.6556
37848864	BMC genomics	2023	Identification and characterization of differentially expressed circular RNAs in extraocular muscle of oculomotor nerve palsy.		circRNA_02140			oculomotor nerve palsy / ONP	MONDO:0001309	oculomotor nerve paralysis	up-regulated	RT-qPCR; RNA-seq	"circRNA_02140 is increased in ONP medial rectus muscle compared with CXT controls and was validated by RT-qPCR, but no specific downstream mechanism or clinical role was further characterized in this study."	0.3588
37848864	BMC genomics	2023	Identification and characterization of differentially expressed circular RNAs in extraocular muscle of oculomotor nerve palsy.		circRNA_02453			oculomotor nerve palsy / ONP	MONDO:0001309	oculomotor nerve paralysis	up-regulated	RT-qPCR; RNA-seq	"circRNA_02453 is up-regulated in ONP medial rectus muscle compared with CXT controls (validated by RT-qPCR) and is predicted to interact with hsa-miR-503-5p and hsa-miR-6715a-3p, but its downstream targets and functional consequences were not experimentally characterized."	0.4032
37848864	BMC genomics	2023	Identification and characterization of differentially expressed circular RNAs in extraocular muscle of oculomotor nerve palsy.		circRNA_06396			oculomotor nerve palsy / ONP	MONDO:0001309	oculomotor nerve paralysis	down-regulated	RT-qPCR; RNA-seq	"circRNA_06396 is down-regulated in ONP medial rectus muscle compared with CXT controls and was validated by RT-qPCR, but no specific mechanism, pathway, or clinical relevance was further investigated."	0.3588
37858140	Arthritis research & therapy	2023	CircPTPN22 modulates T-cell activation by sponging miR-4689 to regulate S1PR1 expression in patients with systemic lupus erythematosus.		circPTPN22	hsa_circ_PTPN22	PTPN22	systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	down-regulated	RT-qPCR	"circPTPN22 is down-regulated in PBMCs from SLE patients and is associated with disease activity. In Jurkat T cells, circPTPN22 promotes proliferation and inhibits apoptosis, and suppresses TNF-alpha/IL-6 secretion by acting as a miR-4689 sponge to de-repress S1PR1 (circPTPN22/miR-4689/S1PR1 axis), with links to JAK-STAT-related signaling."	0.7295
37864285	Thoracic cancer	2023	Circ_0102231 inactivates the PI3K/AKT signaling pathway by regulating the miR-635/NOVA2 pathway to promote the progression of non-small cell lung cancer.	hsa_circ_0102231	circ_0102231	hsa_circ_KIAA0586	KIAA0586	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0102231 is up-regulated in NSCLC tissues/cells and is associated with advanced clinicopathological features. Functionally, circ_0102231 promotes NSCLC proliferation and angiogenesis and suppresses apoptosis, and its knockdown inhibits xenograft tumor growth. Mechanistically, circ_0102231 acts as a ceRNA sponge for miR-635 to derepress NOVA2 and activate PI3K/AKT signaling."	0.8327
37864310	Journal of cellular and molecular medicine	2023	Circ-ILF2 in oral squamous cell carcinoma promotes cisplatin resistance and induces M2 polarization of macrophages.		circ_ILF2 / hsa_circ_001428	hsa_circ_ILF2	ILF2	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circ_ILF2 is upregulated in cisplatin-resistant OSCC cell lines and promotes CDDP resistance by reducing CDDP-induced apoptosis and sustaining cell growth. Mechanistically, it mainly localizes to the cytoplasm and acts as a sponge for miR-1252, thereby relieving miR-1252-mediated repression of KLF8. circ-ILF2 in OSCC cells also promotes M2 polarization of macrophages in a coculture system."	0.7822
37866478	Cellular and molecular gastroenterology and hepatology	2024	Circ-CCT2 Activates Wnt/beta-catenin Signaling to Facilitate Hepatoblastoma Development by Stabilizing PTBP1 mRNA.	hsa_circ_0000418	Circ-CCT2	hsa_circ_CCT2	CCT2	hepatoblastoma / HB	MONDO:0018666	hepatoblastoma	up-regulated	RT-qPCR; ISH	"circ-CCT2 is up-regulated in hepatoblastoma and mainly localizes to the cytoplasm. It promotes malignant phenotypes and xenograft tumor growth by recruiting/up-regulating the RBP TAF15, thereby stabilizing PTBP1 mRNA and activating Wnt/beta-catenin signaling."	0.8232
37869777	CNS neuroscience & therapeutics	2024	Circular RNA PTP4A2 regulates microglial polarization through STAT3 to promote neuroinflammation in ischemic stroke.		circPTP4A2 / Circular RNA PTP4A2	mmu_circ_PTP4A2	PTP4A2	ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR	"In tMCAO/OGD-R ischemic stroke models, circPTP4A2 is up-regulated (plasma and peri-infarct cortex) and mainly elevated in microglia. circPTP4A2 directly binds STAT3 and promotes STAT3 phosphorylation, driving pro-inflammatory (M1) microglial polarization and neuroinflammation; circPTP4A2 knockdown reduces ischemic injury and shifts microglia toward the anti-inflammatory M2 phenotype."	0.7849
37870214	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2023	CircNOLC1 Promotes Colorectal Cancer Liver Metastasis by Interacting with AZGP1 and Sponging miR-212-5p to Regulate Reprogramming of the Oxidative Pentose Phosphate Pathway.	hsa_circ_0000257	circNOLC1	hsa_circ_NOLC1	NOLC1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; Microarray	"circNOLC1 is up-regulated in CRC, especially in liver metastasis, and promotes CRC cell proliferation, migration, and liver metastatic colonization. Mechanistically, circNOLC1 binds AZGP1 to activate mTOR/SREBP1 signaling and also sponges miR-212-5p to increase c-Met, converging on G6PD activation and oxidative PPP reprogramming with increased NADPH/ROS buffering."	0.8665
37871516	Translational oncology	2024	CircNEK6 promotes the progression of pancreatic ductal adenocarcinoma through targeting miR-503/CCND1 axis.	hsa_circ_0088485	circNEK6	hsa_circ_NEK6	NEK6	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"CircNEK6 is up-regulated in PDAC tissues/cell lines and its high expression is associated with worse OS and PFS. Functionally, circNEK6 promotes PDAC proliferation, migration and invasion and suppresses apoptosis, and its silencing inhibits xenograft tumor growth. Mechanistically, circNEK6 acts as a ceRNA by sponging miR-503 to increase CCND1 expression, affecting cell-cycle progression."	0.7096
37872772	"Cell cycle (Georgetown, Tex.)"	2023	Tumor-derived CircRNA_102191 promotes gastric cancer and facilitates M2 macrophage polarization.	hsa_circ_0045602	circRNA_102191	hsa_circ_HN1	HN1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circRNA_102191 is up-regulated in gastric cancer tissues/cell lines and promotes malignant phenotypes (proliferation, migration/invasion, EMT) while inhibiting apoptosis. Mechanistically, it functions as a ceRNA sponging miR-493-3p to increase XPR1 expression and also enhances M2 macrophage polarization, which further supports EMT and tumor progression."	0.7898
37877357	Clinical and translational medicine	2023	N6 -methyladenosine-modified circSTX6 promotes hepatocellular carcinoma progression by regulating the HNRNPD/ATF3 axis and encoding a 144 amino acid polypeptide.	hsa_circ_0007905	circSTX6	hsa_circ_STX6	STX6	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH	"circSTX6 (hsa_circ_0007905), derived from STX6, is up-regulated in HCC tumor tissues and predicts worse survival. It predominantly localizes to the cytoplasm where it binds HNRNPD, enhancing HNRNPD-mediated ATF3 mRNA decay, thereby promoting HCC proliferation and metastasis; its expression is modulated by METTL14-dependent m6A modification."	0.9026
37880717	Respiratory research	2023	Circular RNA P4HB promotes glycolysis and tumor progression by binding with PKM2 in lung adenocarcinoma.	hsa_circ_0046263	circP4HB	hsa_circ_P4HB	P4HB	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circP4HB (hsa_circ_0046263), derived from P4HB, is up-regulated in LUAD and promotes tumor progression. It mainly localizes to the cytoplasm and directly binds PKM2, increasing PKM2 tetramer formation and enzymatic activity to enhance aerobic glycolysis, and it also promotes M2 macrophage polarization via PKM2; high circP4HB predicts poor overall survival."	0.8377
37884630	Scientific reports	2023	"Hsa_circRNA_001676 accelerates the proliferation, migration and stemness in colorectal cancer through regulating miR-556-3p/G3BP2 axis."		hsa_circRNA_001676			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_001676 is up-regulated in colorectal cancer tissues and CRC cell lines and promotes proliferation, migration, and stemness. It functions as a ceRNA by sponging miR-556-3p, thereby increasing G3BP2 expression and enhancing stemness-associated markers; its knockdown suppresses tumor growth in a CRC xenograft model."	0.7376
37884951	Molecular cancer	2023	circPSD3 is a promising inhibitor of uPA system to inhibit vascular invasion and metastasis in hepatocellular carcinoma.	hsa_circ_0136098	circRNA pleckstrin and Sect. 7 domain containing 3 / circPSD3	hsa_circ_PSD3	PSD3	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"circPSD3 (hsa_circ_0136098), derived from PSD3, is down-regulated in PVTT and HCC tissues and its low expression predicts worse survival. Functionally, circPSD3 suppresses HCC cell migration/invasion and inhibits vascular invasion and metastasis in vivo by binding HDAC1 to retain it in the cytoplasm, thereby relieving repression of SERPINB2 and inhibiting the uPA/uPAR system."	0.8705
37886542	bioRxiv : the preprint server for biology	2023	Interferon induced circRNAs escape herpesvirus host shutoff and suppress lytic infection.	hsa_circ_0001400	circRELL1	hsa_circ_RELL1	RELL1	Herpes simplex virus-1 / HSV-1 lytic infection	MONDO:0004609	herpes simplex infectious disease	up-regulated	RT-qPCR; RNA-seq	"circRELL1 (hsa_circ_0001400) is induced by herpesvirus infection and interferon stimulation and acts as an antiviral factor by restricting HSV-1 lytic infection. It was reported to interact with TTI1 mRNA (linked to the mTOR complex), suggesting a potential mechanism for suppressing viral replication."	0.5297
37886542	bioRxiv : the preprint server for biology	2023	Interferon induced circRNAs escape herpesvirus host shutoff and suppress lytic infection.	hsa_circ_0000479	circEPSTI1	hsa_circ_EPSTI1	EPSTI1	Herpesvirus infection	MONDO:0005550	infectious disease	up-regulated	RT-qPCR; RNA-seq	"circEPSTI1 (hsa_circ_0000479) is an interferon-stimulated circRNA that is consistently upregulated across IFN-beta/IFN-gamma treatment conditions in multiple cell types, and its induction can also be observed in PBMCs after IFN-beta treatment. The study did not define a specific downstream mechanism for circEPSTI1."	0.4032
37886542	bioRxiv : the preprint server for biology	2023	Interferon induced circRNAs escape herpesvirus host shutoff and suppress lytic infection.	mmu_circ_0001396	circMed13l	mmu_circ_Med13l	Med13l	Herpes simplex virus-1 / HSV-1 lytic infection	MONDO:0004609	herpes simplex infectious disease	up-regulated	RNA-seq	circMed13l (mmu_circ_0001396) is consistently upregulated across the study¡¯s mouse HSV-1 and MHV68 infection models based on RNA-seq profiling. No functional mechanism experiments were reported for this circRNA in the paper.	0.31
37887391	Metabolites	2023	Circulating Exosomal CircRNAs as Diagnostic Biomarkers for Chronic Coronary Syndrome.	hsa_circ_0075269	exo-hsa_circ_0075269			chronic coronary syndrome / CCS	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR; RNA-seq	Circulating exosomal hsa_circ_0075269 is significantly up-regulated in CCS patients versus NCCP controls and shows diagnostic value by ROC analysis (AUC reported). No molecular mechanism or downstream targets were experimentally defined in this study.	0.5047
37887391	Metabolites	2023	Circulating Exosomal CircRNAs as Diagnostic Biomarkers for Chronic Coronary Syndrome.	hsa_circ_0000284	exo-hsa_circ_0000284			chronic coronary syndrome / CCS	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR; RNA-seq	Circulating exosomal hsa_circ_0000284 is significantly up-regulated in CCS patients and has modest diagnostic performance by ROC analysis (AUC reported). This study did not experimentally determine its mechanistic role in CCS.	0.5047
37891516	BMC pulmonary medicine	2023	Identification of potentially functional circRNAs and prediction of the circRNA-miRNA-hub gene network in mice with primary blast lung injury.			mmu_circ_Rnf138	Rnf138	primary blast lung injury / PBLI	MONDO:0015796	acute lung injury	down-regulated	RT-qPCR; RNA-seq	This circRNA (chr18:21008725_21020999_+_; host gene Rnf138) is down-regulated in mouse lung tissue after PBLI and is included in a predicted circRNA_miRNA_hub gene regulatory network. It was experimentally validated by qRT-PCR as significantly changed in PBLI.	0.4997
37891516	BMC pulmonary medicine	2023	Identification of potentially functional circRNAs and prediction of the circRNA-miRNA-hub gene network in mice with primary blast lung injury.			mmu_circ_Zcchc7	Zcchc7	primary blast lung injury / PBLI	MONDO:0015796	acute lung injury	down-regulated	RT-qPCR; RNA-seq	"This circRNA (chr4:44893533_44895989_+_; host gene Zcchc7) is down-regulated in PBLI mouse lung tissue and is part of a predicted circRNA_miRNA_hub gene network. It was included among circRNAs linked to PBLI via bioinformatic prediction and sequencing-based differential expression, and the network circRNAs were validated by qRT-PCR."	0.3684
37891516	BMC pulmonary medicine	2023	Identification of potentially functional circRNAs and prediction of the circRNA-miRNA-hub gene network in mice with primary blast lung injury.			mmu_circ_Tmem245	Tmem245	primary blast lung injury / PBLI	MONDO:0015796	acute lung injury	down-regulated	RT-qPCR; RNA-seq	This circRNA (chr4:56899026_56910247-; host gene Tmem245) is down-regulated in PBLI mouse lung tissue and was qRT-PCR validated as significantly changed. It is a component of the predicted circRNA_miRNA_hub gene network constructed in this study.	0.3684
37891516	BMC pulmonary medicine	2023	Identification of potentially functional circRNAs and prediction of the circRNA-miRNA-hub gene network in mice with primary blast lung injury.			mmu_circ_Zcchc8	Zcchc8	primary blast lung injury / PBLI	MONDO:0015796	acute lung injury	down-regulated	RNA-seq	This circRNA (chr5:123709382_123719528-; host gene Zcchc8) is down-regulated in PBLI mouse lung tissue based on RNA-seq and is included in the predicted circRNA_miRNA_hub gene network. It was not reported as qRT-PCR validated in the network validation set.	0.31
37891516	BMC pulmonary medicine	2023	Identification of potentially functional circRNAs and prediction of the circRNA-miRNA-hub gene network in mice with primary blast lung injury.			mmu_circ_Qrich1	Qrich1	primary blast lung injury / PBLI	MONDO:0015796	acute lung injury	down-regulated	RNA-seq	This circRNA (chr9:108528589_108544977_+_; host gene Qrich1) is down-regulated in PBLI mouse lung tissue based on RNA-seq and is included in the predicted circRNA_miRNA_hub gene network proposed to be relevant to PBLI.	0.31
37891516	BMC pulmonary medicine	2023	Identification of potentially functional circRNAs and prediction of the circRNA-miRNA-hub gene network in mice with primary blast lung injury.		chr15:93452117_93465245_+_			primary blast lung injury / PBLI	MONDO:0015796	acute lung injury	unknown	RNA-seq	"This circRNA (chr15:93452117_93465245_+_) is included as one of six key circRNAs in the predicted circRNA_miRNA_hub gene network associated with PBLI in mice. The paper does not report its host gene, direction of change, or qRT-PCR validation specifically for this circRNA."	0.31
37895312	Genes	2023	Tissue Circular RNA_0004018 and 0003570 as Novel Prognostic Biomarkers for Hepatitis B-Related Hepatocellular Carcinoma.	hsa_circ_0004018		hsa_circ_SMYD4	SMYD4	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"hsa_circ_0004018 is down-regulated in HBV-HCC tumor tissues versus adjacent nontumor tissues. Higher tissue expression is independently associated with longer progression-free survival, supporting its value as a favorable prognostic biomarker in HBV-HCC; this study did not experimentally define its molecular mechanism."	0.5727
37895312	Genes	2023	Tissue Circular RNA_0004018 and 0003570 as Novel Prognostic Biomarkers for Hepatitis B-Related Hepatocellular Carcinoma.	hsa_circ_0003570	circ_0003570	hsa_circ_FAM53B	FAM53B	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"hsa_circ_0003570 is down-regulated in HBV-HCC tumor tissues versus adjacent nontumor tissues. Higher tissue expression is independently associated with longer overall survival, supporting its use as a favorable prognostic biomarker; the study did not experimentally determine the circRNA¡¯s molecular mechanism in this cohort."	0.5727
37898647	Nature communications	2023	A circular RNA activated by TGFbeta promotes tumor metastasis through enhancing IGF2BP3-mediated PDPN mRNA stability.	hsa_circ_0056856	circITGB6	hsa_circ_ITGB6	ITGB6	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Northern Blot; RNA-seq	"circITGB6 (hsa_circ_0056856), a TGFbeta-induced circRNA from ITGB6, is up-regulated in metastatic cancer samples and promotes EMT, migration, and metastasis. It directly binds the RBP IGF2BP3 to enhance PDPN mRNA stability, forming a pro-metastatic circITGB6/IGF2BP3/PDPN axis associated with poor prognosis in CRC."	0.8917
37899885	Pharmacogenomics and personalized medicine	2023	Microarray Expression Profile and Bioinformatic Analysis of Circular RNA in Human Arteriosclerosis Obliterans.	hsa_circ_0003266				Arteriosclerosis obliterans / ASO	MONDO:0006659	arteriosclerosis obliterans	up-regulated	RT-qPCR; Microarray	"hsa_circ_0003266 is up-regulated in ASO arterial tissues versus normal arteries, validated by RT-qPCR. The study further predicts a circRNA_miRNA_mRNA network for this circRNA, suggesting a possible ceRNA role in ASO."	0.4032
37899885	Pharmacogenomics and personalized medicine	2023	Microarray Expression Profile and Bioinformatic Analysis of Circular RNA in Human Arteriosclerosis Obliterans.	hsa_circ_0118936				Arteriosclerosis obliterans / ASO	MONDO:0006659	arteriosclerosis obliterans	up-regulated	RT-qPCR; Microarray	"hsa_circ_0118936 is up-regulated in ASO arterial tissues versus normal arteries, validated by RT-qPCR. The authors suggest it may be a potential diagnostic/prognostic marker, and they predict a circRNA_miRNA_mRNA network implying a possible ceRNA mechanism."	0.4032
37899885	Pharmacogenomics and personalized medicine	2023	Microarray Expression Profile and Bioinformatic Analysis of Circular RNA in Human Arteriosclerosis Obliterans.	hsa_circ_0067161				Arteriosclerosis obliterans / ASO	MONDO:0006659	arteriosclerosis obliterans	up-regulated	RT-qPCR; Microarray	"hsa_circ_0067161 is up-regulated in ASO arterial tissues versus normal arteries, validated by RT-qPCR. The study predicts its circRNA_miRNA_mRNA interaction network, but does not experimentally validate downstream targets or functions."	0.4032
37899885	Pharmacogenomics and personalized medicine	2023	Microarray Expression Profile and Bioinformatic Analysis of Circular RNA in Human Arteriosclerosis Obliterans.	hsa_circ_0091934				Arteriosclerosis obliterans / ASO	MONDO:0006659	arteriosclerosis obliterans	down-regulated	RT-qPCR; Microarray	"hsa_circ_0091934 is down-regulated in ASO arterial tissues versus normal arteries, validated by RT-qPCR. The authors suggest it may be a potential diagnostic/prognostic marker and predict its circRNA_miRNA_mRNA network consistent with a possible ceRNA mechanism."	0.4032
37899885	Pharmacogenomics and personalized medicine	2023	Microarray Expression Profile and Bioinformatic Analysis of Circular RNA in Human Arteriosclerosis Obliterans.	hsa_circ_0092022				Arteriosclerosis obliterans / ASO	MONDO:0006659	arteriosclerosis obliterans	down-regulated	RT-qPCR; Microarray	"hsa_circ_0092022 is down-regulated in ASO arterial tissues versus normal arteries, validated by RT-qPCR. The study predicts its circRNA_miRNA_mRNA network consistent with a possible ceRNA mechanism, without downstream experimental validation."	0.4032
37901849	International journal of clinical practice	2023	Serum Hsa_circ_0005962 Is A Prognostic Biomarker of Paclitaxel Resistance in Nonsmall Cell Lung Cancer Treatment.	hsa_circ_0005962		hsa_circ_YWHAZ	YWHAZ	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0005962 is up-regulated in NSCLC patient serum, especially in paclitaxel-chemoresistant cases, and higher levels correlate with advanced clinicopathological features and worse survival. Functionally, it promotes paclitaxel resistance in NSCLC cells by regulating the miR-126-5p/IGF1 axis and shows diagnostic/prognostic value (ROC and survival analyses)."	0.7682
37903473	Journal of innate immunity	2023	YTHDC1-Modified m6A Methylation of Hsa_circ_0102678 Promotes Keratinocyte Inflammation Induced by Cutibacterium acnes Biofilm through Regulating miR-146a/TRAF6 and IRAK1 Axis.	hsa_circ_0102678		hsa_circ_CRIM1	CRIM1	acne	MONDO:0011438	acne	down-regulated	RT-qPCR; ISH; Microarray	"In acne, hsa_circ_0102678 is down-regulated in lesional tissues but promotes C. acnes biofilm-induced inflammatory responses in human primary keratinocytes. Mechanistically, YTHDC1 mediates m6A-dependent nuclear export of hsa_circ_0102678, and cytoplasmic hsa_circ_0102678 sponges miR-146a to upregulate IRAK1 and TRAF6, enhancing MAPK/NF-kappaB-associated inflammation."	0.7859
37907264	"Journal of neurological surgery. Part A, Central European neurosurgery"	2025	Exosomal CircMFN2 Enhances the Progression of Pituitary Adenoma via the MiR-146a-3p/TRAF6/NF-kappaB Pathway.		circMFN2	hsa_circ_MFN2	MFN2	pituitary adenoma / PA	MONDO:0006373	pituitary gland adenoma	up-regulated	RT-qPCR; Microarray	"circMFN2 is up-regulated in invasive pituitary adenoma and is elevated in patient serum and serum exosomes. Functionally, circMFN2 promotes PA cell proliferation, migration and invasion, mainly by sponging miR-146a-3p and modulating the TRAF6/NF-kappaB axis. It also shows diagnostic potential for PA (ROC AUC 0.802)."	0.6772
37907737	Experimental & molecular medicine	2023	"Circular RNA cFAM210A, degradable by HBx, inhibits HCC tumorigenesis by suppressing YBX1 transactivation."	hsa_circ_0003979	cFAM210A / circRNA-cFAM210A	hsa_circ_FAM210A	FAM210A	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"In HBV-related HCC, cFAM210A is down-regulated and acts as a tumor suppressor by inhibiting HCC cell proliferation, stemness and tumorigenicity. HBx induces RBM15-mediated m6A modification of cFAM210A and promotes its YTHDF2-HRSP12-RNase P/MRP-dependent degradation. cFAM210A binds YBX1, inhibits YBX1 Ser102 phosphorylation, and suppresses YBX1 transactivation of MET, linking low cFAM210A to worse recurrence outcomes."	0.8712
37909033	Frontiers in neurology	2023	Altered expression of circular RNA in patients with cervical artery dissection.		"hsa_circ:chr17:81042814_81,043,199"	hsa_circ_METRNL	METRNL	Cervical artery dissection / CeAD	MONDO:0006061	cervical artery dissection	down-regulated	RT-qPCR; RNA-seq	This circRNA (METRNL-derived) is down-regulated in PBMCs of CeAD patients and was confirmed by qRT-PCR. The study suggests it may participate in CeAD-related stroke pathophysiology based on predicted circRNA-miRNA-mRNA networks and GO/KEGG enrichment.	0.5135
37909033	Frontiers in neurology	2023	Altered expression of circular RNA in patients with cervical artery dissection.		"hsa_circ:chr1:2234417_2,236,024"	hsa_circ_SKI	SKI	Cervical artery dissection / CeAD	MONDO:0006061	cervical artery dissection	down-regulated	RT-qPCR; RNA-seq	This SKI-derived circRNA is down-regulated in PBMCs of CeAD patients and validated by qRT-PCR. Bioinformatics suggests it may act as a miRNA sponge (notably for miR-4443) and be related to immune/inflammatory processes in CeAD-associated stroke.	0.5135
37909033	Frontiers in neurology	2023	Altered expression of circular RNA in patients with cervical artery dissection.		"hsa_circ:chr1:31465237_31,479,949"	hsa_circ_PUM1	PUM1	Cervical artery dissection / CeAD	MONDO:0006061	cervical artery dissection	down-regulated	RT-qPCR; RNA-seq	This PUM1-derived circRNA is down-regulated in PBMCs of CeAD patients and validated by qRT-PCR. The paper implicates it in CeAD-associated stroke processes based on predicted circRNA-miRNA-mRNA networks and enrichment analyses.	0.5135
37920146	Thoracic cancer	2023	Circ_0004140 promotes lung adenocarcinoma progression by upregulating NOVA2 via sponging miR-330-5p.	hsa_circ_0004140	circ_0004140	hsa_circ_YAP1	YAP1	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"circ_0004140 is up-regulated in lung adenocarcinoma tissues/cell lines and functions as an oncogenic circRNA. It sponges miR-330-5p to relieve repression of NOVA2, thereby promoting proliferation, migration, invasion and angiogenesis and inhibiting apoptosis, and it supports tumor growth in a cell line-derived xenograft model."	0.7418
37924099	Cancer cell international	2023	Exosomal circRNA RHOT1 promotes breast cancer progression by targeting miR-204-5p/ PRMT5 axis.		Circular RNA RHOT1 / circRHOT1	hsa_circ_RHOT1	RHOT1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"Exosomal circRHOT1 is up-regulated in breast cancer patient serum exosomes, tumor tissues, and breast cancer cells. It promotes breast cancer proliferation, migration/invasion and EMT while inhibiting apoptosis by sponging miR-204-5p, thereby increasing PRMT5 expression; circRHOT1 knockdown in exosomes suppresses tumor growth in nude mice."	0.7892
37925174	Aging	2023	Identification of circRNA-miRNA-mRNA network as biomarkers for interstitial cystitis/bladder pain syndrome.		circ.5863 / circRNA.5863	hsa_circ_SMTN	SMTN	interstitial cystitis	MONDO:0018301	interstitial cystitis	down-regulated	RT-qPCR; RNA-seq	"circ.5863 (SMTN-derived) is down-regulated in IC/BPS (patient bladder tissue sequencing and LPS-induced HUC model). Lentiviral overexpression of circ.5863 alleviates inflammatory damage by reducing inflammatory cytokines (IL-6, IL-1beta, TNF-alpha), and may act via sponging miR-20b-5p."	0.4062
37925174	Aging	2023	Identification of circRNA-miRNA-mRNA network as biomarkers for interstitial cystitis/bladder pain syndrome.		circ.8015 / circRNA.8015	hsa_circ_TBC1D1	TBC1D1	interstitial cystitis	MONDO:0018301	interstitial cystitis	down-regulated	RNA-seq	"circ.8015 (host gene TBC1D1) was identified as a down-regulated DEcircRNA included in the constructed circRNA-miRNA-mRNA network for IC/BPS, but no specific functional experiments or mechanism were reported for this circRNA."	0.1155
37925174	Aging	2023	Identification of circRNA-miRNA-mRNA network as biomarkers for interstitial cystitis/bladder pain syndrome.		circ.8742 / circRNA.8742	hsa_circ_TMEM161B-AS1	TMEM161B-AS1	interstitial cystitis	MONDO:0018301	interstitial cystitis	down-regulated	RNA-seq	"circ.8742 (host gene TMEM161B-AS1) was identified as a down-regulated DEcircRNA in the IC/BPS circRNA-miRNA-mRNA network, but the paper did not report its specific interacting miRNAs, downstream targets, or functional validation."	0.1155
37925421	Signal transduction and targeted therapy	2023	SUMOylation-triggered ALIX activation modulates extracellular vesicles circTLCD4-RWDD3 to promote lymphatic metastasis of non-small cell lung cancer.	hsa_circ_0000095	circTLCD4-RWDD3	hsa_circ_TLCD4-RWDD3	TLCD4-RWDD3	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circTLCD4-RWDD3 is overexpressed in NSCLC (especially LN-positive cases) and enriched in NSCLC-derived extracellular vesicles, where it promotes lymphangiogenesis and lymph node metastasis. Mechanistically, it binds hnRNPA2B1 and transcriptionally upregulates UBC9 to drive hnRNPA2B1 SUMO2-K108 modification, enabling SIM-dependent ALIX activation and ESCRT-III recruitment for EV sorting; EV-delivered circTLCD4-RWDD3 activates PROX1 transcription in HLECs to enhance lymphangiogenic phenotypes and metastasis."	0.9031
37925795	Translational oncology	2024	Hsa_circ_0020134 promotes liver metastasis of colorectal cancer through the miR-183-5p-PFN2-TGF-beta/Smad axis.	hsa_circ_0020134	circ0020134	hsa_circ_CACUL1	CACUL1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0020134 (circ0020134), derived from CACUL1, is up-regulated in CRC liver metastases and is associated with worse overall survival. It promotes CRC proliferation and metastasis by sponging miR-183-5p to increase PFN2 expression, activating TGF-beta/Smad signaling and EMT; its expression is transcriptionally induced by PAX5."	0.8941
37932766	Molecular cancer	2023	CircHERC1 promotes non-small cell lung cancer cell progression by sequestering FOXO1 in the cytoplasm and regulating the miR-142-3p-HMGB1 axis.	hsa_circ_0035796	circHERC1 / hsa_circHERC1	hsa_circ_HERC1	HERC1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"circHERC1 is up-regulated in NSCLC patient plasma/tissues and promotes malignant phenotypes. It enhances migration/invasion via the ceRNA axis circHERC1_miR-142-3p_HMGB1, activating MAPK/ERK and NF-kappaB signaling, and promotes proliferation while inhibiting apoptosis by binding FOXO1 and retaining it in the cytoplasm to feedback-activate AKT and affect BIM transcription."	0.868
37938614	Scientific reports	2023	Circ_ZNF778_006 promoted ESCC progression by upregulating HIF-1alpha expression via sponging miR-18b-5p.		circ_ZNF778_006 / circZNF778_006	hsa_circ_ZNF778	ZNF778	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"circ_ZNF778_006 is up-regulated in ESCC tissues and correlates with higher tumor stage. Functionally, it promotes ESCC cell proliferation, migration/invasion, EMT and xenograft tumor growth, and decreases sensitivity to 5-Fu and cisplatin. Mechanistically, it acts as a ceRNA by sponging miR-18b-5p to upregulate HIF-1alpha."	0.797
37940358	Cancer science	2024	CircBRD7 attenuates tumor growth and metastasis in nasopharyngeal carcinoma via epigenetic activation of its host gene.	hsa_circ_0039345	circBRD7 / circ_0039345	hsa_circ_BRD7	BRD7	nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	down-regulated	RT-qPCR; ISH	"circBRD7 (hsa_circ_0039345) is down-regulated in nasopharyngeal carcinoma and acts as a tumor suppressor by inhibiting proliferation, migration/invasion, EMT, tumor growth, and metastasis. It enhances BRD7 transcription via increased H3K27ac enrichment at the BRD7 promoter and forms a positive feedback loop with its host gene BRD7, which mediates much of its anti-tumor effect."	0.8661
37945594	Scientific reports	2023	The integrative multi-omics approach identifies the novel competing endogenous RNA (ceRNA) network in colorectal cancer.	hsa_circ_000240	circ000240 / hsa_circ000240	hsa_circ_LGALS3BP	LGALS3BP	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"This study reports that hsa_circ_000240 (from host gene LGALS3BP) is up-regulated in colorectal cancer tissues. It is proposed to function as a ceRNA by binding miR-646, miR-665, and miR-526b-3p to influence downstream target genes (including hub genes such as CDC6 and ORC1) in CRC."	0.2995
37947656	Cells	2023	circRNA-miRNA-mRNA Deregulated Network in Ischemic Heart Failure Patients.	hsa_circ_0000799	circBPTF	hsa_circ_BPTF	BPTF	ischemic heart failure / IHF	MONDO:0005252	heart failure	up-regulated	RT-qPCR; RNA-seq	circBPTF is upregulated in ischemic heart failure LV tissue and induced by hypoxia in endothelial cells. It functions as a ceRNA hub binding multiple miRNAs (notably miR-196b-5p) to modulate target mRNAs such as HDAC9 and LRRC17. circBPTF inhibition suppresses endothelial proliferation and causes cell-cycle arrest with increased cell death.	0.7888
37947656	Cells	2023	circRNA-miRNA-mRNA Deregulated Network in Ischemic Heart Failure Patients.		circANKRD17	hsa_circ_ANKRD17	ANKRD17	ischemic heart failure / IHF	MONDO:0005252	heart failure	up-regulated	RT-qPCR	"circANKRD17 is significantly upregulated in LV tissue from non-end-stage IHF patients and is included as one of the five circRNAs forming the IHF ceRNA network. It is computationally linked to miR-7-5p and miR-182-3p/5p within the circRNA-miRNA-mRNA interaction network, but no dedicated functional experiments were reported for circANKRD17."	0.348
37947656	Cells	2023	circRNA-miRNA-mRNA Deregulated Network in Ischemic Heart Failure Patients.		circHIPK3	hsa_circ_HIPK3	HIPK3	ischemic heart failure / IHF	MONDO:0005252	heart failure	down-regulated	RT-qPCR	"circHIPK3 is significantly downregulated in LV tissue from non-end-stage IHF patients and is included as a driver in the constructed IHF ceRNA network. It is computationally linked to miR-551b-3p in the circRNA-miRNA-mRNA interaction table, but no dedicated experimental functional validation was reported for circHIPK3 in this paper."	0.348
37947656	Cells	2023	circRNA-miRNA-mRNA Deregulated Network in Ischemic Heart Failure Patients.		circPVT1	hsa_circ_PVT1	PVT1	ischemic heart failure / IHF	MONDO:0005252	heart failure	up-regulated	RT-qPCR	"circPVT1 is significantly upregulated in LV tissue from non-end-stage IHF patients and is included as one of the five circRNAs in the IHF ceRNA network. It is computationally linked to miR-30a-5p and miR-30d-5p within the network, but no circPVT1-specific mechanistic experiments were reported."	0.348
37947656	Cells	2023	circRNA-miRNA-mRNA Deregulated Network in Ischemic Heart Failure Patients.		circSLC8A1	hsa_circ_SLC8A1	SLC8A1	ischemic heart failure / IHF	MONDO:0005252	heart failure	up-regulated	RT-qPCR	"circSLC8A1 is significantly upregulated in LV tissue from non-end-stage IHF patients and is included in the constructed IHF ceRNA network. It is computationally linked to miR-338-3p/miR-338-5p interactions in the network, but no circSLC8A1-focused mechanistic experiments were performed in this study."	0.348
37950151	BMC cancer	2023	Circular RNA ZNF800 (hsa_circ_0082096) regulates cancer stem cell properties and tumor growth in colorectal cancer.	hsa_circ_0082096	Circular RNA ZNF800 / circZNF800	hsa_circ_ZNF800	ZNF800	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circZNF800 (hsa_circ_0082096), derived from the host gene ZNF800, is up-regulated in late-stage colorectal cancer tumor tissues and CRC stem cell-enriched spheroids. It promotes cancer stem cell properties and tumor growth by sponging miR-140-3p/miR-382-5p/miR-579-3p and increasing ALK7/ACVR1C, FZD3, and WNT5A expression."	0.7977
37953225	Respiratory research	2023	Circ_16601 facilitates Hippo pathway signaling via the miR-5580-5p/FGB axis to promote my-CAF recruitment in the TME and LUAD progression.		circ_16601	hsa_circ_DNAH14	DNAH14	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circ_16601 is up-regulated in LUAD and promotes tumor proliferation, migration/invasion, and xenograft growth. It acts as a ceRNA by sponging miR-5580-5p to stabilize/upregulate FGB, which activates Hippo/YAP1 signaling; exosomal circ_16601 also promotes my-CAF recruitment/formation in the TME and is associated with poor prognosis."	0.8836
37953462	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2024	A Mammalian Conserved Circular RNA CircLARP1B Regulates Hepatocellular Carcinoma Metastasis and Lipid Metabolism.		circLARP1B	hsa_circ_LARP1B	LARP1B	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Northern Blot; ISH; RNA-seq	"circLARP1B is up-regulated in metastatic HCC and promotes invasion/metastasis and lipid accumulation. Mechanistically, it binds cytoplasmic HNRNPD, reduces HNRNPD binding to LKB1 mRNA 3¡ä UTR, destabilizes LKB1 mRNA and lowers LKB1 protein, thereby suppressing AMPK activation and enhancing fatty acid synthesis."	0.8826
37953462	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2024	A Mammalian Conserved Circular RNA CircLARP1B Regulates Hepatocellular Carcinoma Metastasis and Lipid Metabolism.		circLARP1B	mmu_circ_LARP1B	LARP1B	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Northern Blot; ISH; RNA-seq	"circLARP1B is up-regulated in metastatic HCC and promotes invasion/metastasis and lipid accumulation. Mechanistically, it binds cytoplasmic HNRNPD, reduces HNRNPD binding to LKB1 mRNA 3¡ä UTR, destabilizes LKB1 mRNA and lowers LKB1 protein, thereby suppressing AMPK activation and enhancing fatty acid synthesis."	0.8826
37953794	PeerJ	2023	circMSH3 is a potential biomarker for the diagnosis of colorectal cancer and affects the distant metastasis of colorectal cancer.	hsa_circ_0003761	circMSH3	hsa_circ_MSH3	MSH3	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"circMSH3 (hsa_circ_0003761), derived from the MSH3 gene, is up-regulated in colorectal cancer tissues and CRC cell lines. Its expression is associated with distant metastasis and shows moderate diagnostic performance (AUC 0.75). Mechanistically, circMSH3 binds multiple RNA-binding proteins and directly binds hsa-miR-409-3p, hsa-miR-942-5p, and hsa-miR-1276."	0.7988
37954137	iScience	2023	N6-methyladenosine modification promotes hepatocarcinogenesis through circ-CDYL-enriched and EpCAM-positive liver tumor-initiating exosomes.		Circ-CDYL	hsa_circ_CDYL	CDYL	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"Circ-CDYL is up-regulated in very early/early HCC and is enriched in EpCAM+ plasma exosomes (LTi-Exos). m6A modification (via METTL3) promotes its back-splicing/biogenesis through YTHDC1 and enhances its loading into exosomes through hnRNPA2/B1, enabling exosomal transfer that activates HDGF-PI3K-AKT-mTOR and HIF1AN-NOTCH2 signaling to promote stemness and tumor initiation. Exosomal Circ-CDYL (alone or combined with EpCAM+ exosomes and AFP) shows strong potential for early HCC diagnosis by ROC analysis."	0.8621
37954397	Heliyon	2023	In silico whole-transcriptome analysis reveals a potential hsa_circ_0000375-miR-424-5p-TPM2/SRPX/SRGAP1 regulatory network related to liver metastasis of colorectal cancer.	hsa_circ_0000375		hsa_circ_IFFO1	IFFO1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0000375 is down-regulated in CRC tissues with liver metastasis versus without metastasis and is proposed to act in a ceRNA network by sponging miR-424-5p to modulate TPM2, SRPX and SRGAP1. Functionally, reducing hsa_circ_0000375 decreases CRC cell migration, and the effect is partially reversible via miR-424-5p inhibition."	0.5623
37955024	International journal of chronic obstructive pulmonary disease	2023	Expression Profiles of circRNAs and Identification of hsa_circ_0007608 and hsa_circ_0064656 as Potential Biomarkers for COPD-PH Patients.	hsa_circ_0007608		hsa_circ_ASH1L	ASH1L	pulmonary hypertension in COPD / COPD-PH	MONDO:0005149	pulmonary hypertension	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0007608 is up-regulated in COPD-PH (validated by qRT-PCR) and is highlighted as a potential biomarker/marker. The study proposes it may act via a predicted circRNA-miRNA-mRNA (ceRNA) network and be related to proliferation, migration and EndMT, with enrichment in pathways including NF-kappaB, TGF-beta, MAPK and TNF signaling."	0.4032
37955024	International journal of chronic obstructive pulmonary disease	2023	Expression Profiles of circRNAs and Identification of hsa_circ_0007608 and hsa_circ_0064656 as Potential Biomarkers for COPD-PH Patients.	hsa_circ_0064656		hsa_circ_TGFBR2	TGFBR2	pulmonary hypertension in COPD / COPD-PH	MONDO:0005149	pulmonary hypertension	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0064656 shows abnormal expression in COPD-PH: up-regulated in patient serum but decreases in hypoxic HPAECs while increasing in hypoxic HPASMCs. The study suggests it may participate in COPD-PH through a predicted ceRNA network and processes linked to proliferation, migration and EndMT, with enrichment in NF-kappaB, TGF-beta, MAPK and TNF signaling."	0.4032
37957232	Scientific reports	2023	Circ_0004535/miR-1827/CASP8 network involved in type 2 diabetes mellitus with nonalcoholic fatty liver disease.	hsa_circ_0004535	Circ_0004535 			type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0004535 is down-regulated in PBMC from T2DM, NAFLD, and especially T2DM with NAFLD patients. It forms a ceRNA axis with hsa-miR-1827 to regulate CASP8, with binding supported by luciferase assays, and its overexpression ameliorates high-glucose-induced steatosis-related phenotypes in LO2 cells."	0.6777
37966336	Asian journal of andrology	2024	Knocking down AR promotes osteoblasts to recruit prostate cancer cells by altering exosomal circ-DHPS/miR-214-3p/CCL5 pathway.	hsa_circ_0000893		hsa_circ_DHPS	DHPS	prostate cancer / PCa	MONDO:0008315 	prostate cancer	up-regulated	RT-qPCR	"In prostate cancer bone metastasis, AR inhibition increases exosomal circ-DHPS, which is transferred to osteoblasts. circ-DHPS sponges miR-214-3p to de-repress CCL5, elevating osteoblast CCL5 and thereby enhancing recruitment/migration of PCa cells into the bone microenvironment."	0.7158
37969381	Translational cancer research	2023	Decreased expression of hsa_circ_0112879 in oral squamous cell carcinoma and its clinicopathological implications.	hsa_circ_0112879		hsa_circ_ZNF124	ZNF124	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR	"hsa_circ_0112879 is down-regulated in OSCC tissues and OSCC cell lines. It is associated with pathological differentiation and shows diagnostic potential (ROC AUC=0.798). The study predicts binding to hsa-miR-654-3p, hsa-miR-338-3p and hsa-miR-155-3p and uses hsa_circ_0112879-related miRNAs to build a prognostic risk model, but does not experimentally validate a downstream ceRNA axis."	0.459
37973787	Cell death & disease	2023	Specific intracellular retention of circSKA3 promotes colorectal cancer metastasis by attenuating ubiquitination and degradation of SLUG.	hsa_circ_0000467	CircSKA3	hsa_circ_SKA3	SKA3	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"circSKA3 (hsa_circ_0000467) is upregulated in CRC tumor tissues and mainly localizes to the cytoplasm. It directly binds SLUG via a cellmotif element to inhibit SLUG ubiquitination/proteasomal degradation, thereby promoting EMT, migration/invasion, and metastasis; FUS promotes circSKA3 circularization by binding a cis-motif."	0.8829
37978903	Cancer biology & therapy	2023	hsa_circ_0020378 regulating miR-339-3p/COL1A1 promotes osteosarcoma progression.	hsa_circ_0020378	circ_0020378 / circ _0020378			osteosarcoma	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"hsa_circ_0020378 (circ_0020378) is up-regulated in osteosarcoma tissues and cell lines and promotes proliferation, migration, colony formation, and xenograft tumor growth. Mechanistically, it functions as a ceRNA by sponging miR-339-3p, thereby increasing COL1A1 expression and driving osteosarcoma progression."	0.7795
37979155	Epigenetics	2023	Regulatory networks of circRNA- centred ceRNAs in sepsis-induced acute kidney injury.		circPsen1	mmu_circ_Psen1	Psen1	sepsis-induced acute kidney injury / SAKI	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR; Microarray	"circPsen1 is up-regulated in the renal cortex of CLP-induced SAKI mice and shows similar up-regulation in LPS-stimulated tubular epithelial cells. Pharmacologic inhibition of NF-kappaB nuclear translocation abolishes its LPS-induced upregulation, supporting NF-kappaB-dependent regulation."	0.5922
37979155	Epigenetics	2023	Regulatory networks of circRNA- centred ceRNAs in sepsis-induced acute kidney injury.		circGrm8	mmu_circ_Grm8	Grm8	sepsis-induced acute kidney injury / SAKI	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR; Microarray	"circGrm8 is up-regulated in CLP-induced SAKI mouse renal cortex and also increases in LPS-stimulated tubular epithelial cells. Blocking NF-kappaB nuclear translocation abolishes its LPS-induced upregulation, indicating dependence on NF-kappaB activation."	0.5922
37979155	Epigenetics	2023	Regulatory networks of circRNA- centred ceRNAs in sepsis-induced acute kidney injury.		circNpr3	mmu_circ_Npr3	Npr3	sepsis-induced acute kidney injury / SAKI	MONDO:0002492	acute kidney injury	down-regulated	RT-qPCR; Microarray	"circNpr3 is down-regulated in CLP-induced SAKI mouse renal cortex and shows corresponding downregulation in LPS-stimulated tubular epithelial cells. NF-kappaB nuclear translocation inhibitors block this LPS-induced decrease, linking circNpr3 dysregulation to NF-kappaB signaling activity."	0.5922
37979155	Epigenetics	2023	Regulatory networks of circRNA- centred ceRNAs in sepsis-induced acute kidney injury.		circC3	mmu_circ_C3	C3	sepsis-induced acute kidney injury / SAKI	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR; Microarray	"circC3 is up-regulated in SAKI and is transcriptionally induced by NF-kappaB/p65 in mouse tubular epithelial cells, supported by p65 depletion experiments and promoter binding evidence from ChIP. It is presented as part of NF-kappaB-centered regulatory networks in SAKI."	0.5495
37979155	Epigenetics	2023	Regulatory networks of circRNA- centred ceRNAs in sepsis-induced acute kidney injury.		circZbtb16	mmu_circ_Zbtb16	Zbtb16	sepsis-induced acute kidney injury / SAKI	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR; Microarray	"circZbtb16 is up-regulated in SAKI and is transcriptionally induced by NF-kappaB/p65 in mouse tubular epithelial cells, supported by p65 depletion and ChIP evidence for promoter binding. It is part of NF-kappaB-centered regulatory networks described in this study."	0.5495
37979155	Epigenetics	2023	Regulatory networks of circRNA- centred ceRNAs in sepsis-induced acute kidney injury.		circFkbp5	mmu_circ_Fkbp5	Fkbp5	sepsis-induced acute kidney injury / SAKI	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR; Microarray	"circFkbp5 is induced downstream of NF-kappaB/p65 and promotes tubular epithelial cell apoptosis in SAKI models. Mechanistically, it acts as a ceRNA by sponging miR-760-3p to increase Tnf-alpha, thereby enhancing p65 phosphorylation and NF-kappaB signaling in a positive feedback loop."	0.6528
37980493	Journal of orthopaedic surgery and research	2023	Circ_0020014 mediates CTSB expression and participates in IL-1beta-prompted chondrocyte injury via interacting with miR-24-3p.	hsa_circ_0020014	circ_0020014	hsa_circ_DUSP5	DUSP5	osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circ_0020014 is up-regulated in OA articular cartilage and in IL-1beta-stimulated human chondrocytes, and it aggravates IL-1beta-induced chondrocyte injury. It mainly acts as a ceRNA by sponging miR-24-3p to increase CTSB, thereby promoting apoptosis, inflammation, oxidative stress and reduced proliferation/viability."	0.7977
37981709	Cancer cell international	2023	Hsa_circ_0022383 promote non-small cell lung cancer tumorigenesis through regulating the miR-495-3p/KPNA2 axis.	hsa_circ_0022383	circ_0022383 / circ0022383	hsa_circ_FADS2	FADS2	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0022383 is up-regulated in NSCLC tissues and cell lines and is associated with advanced stage, lymph node metastasis, and poor prognosis. Functionally, it promotes proliferation and migration/metastasis, and in vivo tumor growth. Mechanistically, it mainly localizes to the cytoplasm and acts as a ceRNA sponge for miR-495-3p to regulate KPNA2."	0.8632
37990246	Immunity & ageing : I & A	2023	Circular RNA ZBTB46 depletion alleviates the progression of Atherosclerosis by regulating the ubiquitination and degradation of hnRNPA2B1 via the AKT/mTOR pathway.		CircZBTB46	hsa_circ_ZBTB46	ZBTB46	coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR; ISH	"circZBTB46 is up-regulated in human atherosclerotic plaques/CAD contexts and promotes plaque progression. Functionally, circZBTB46 supports endothelial and smooth muscle cell proliferation and migration while suppressing apoptosis. Mechanistically, it binds hnRNPA2B1 to reduce its ubiquitination and proteasomal degradation and modulates the PTEN/AKT/mTOR signaling pathway."	0.811
37990246	Immunity & ageing : I & A	2023	Circular RNA ZBTB46 depletion alleviates the progression of Atherosclerosis by regulating the ubiquitination and degradation of hnRNPA2B1 via the AKT/mTOR pathway.	mmu_circ_0009684	murine circZBTB46 homolog	mmu_circ_ZBTB46	ZBTB46	atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	The mouse homolog mmu_circ_0009684 is up-regulated in heart tissues from an ApoE_/_ high-fat diet atherosclerosis model compared with controls; no additional functional/mechanistic experiments specific to mmu_circ_0009684 are described.	0.2586
37993106	Thoracic cancer	2024	Circ_0020123 promotes non-small cell lung cancer progression via miR-146a-5p mediated regulation of EIF4G2 expression.	hsa_circ_0020123	circ_0020123	hsa_circ_PDZD8	PDZD8	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0020123 is up-regulated in NSCLC tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion) while inhibiting apoptosis. Mechanistically, it sponges miR-146a-5p to relieve repression of EIF4G2, and its knockdown suppresses tumor growth in a xenograft model."	0.7797
37993113	Thoracic cancer	2024	Gentiana macrophylla flavonoids from Tibetan medicine decreases circ_0059665 to alleviate the progression of non-small cell lung cancer under hypoxia.	hsa_circ_0059665	circ_0059665 / hsa_circRNA_059665			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0059665 is up-regulated in NSCLC tissues/cells and further induced by hypoxia. It promotes NSCLC proliferation, invasion, and M2 macrophage polarization by sponging miR-512-3p to increase NOVA2, while Gentiana macrophylla flavonoids suppress NSCLC progression partly by downregulating circ_0059665."	0.8175
37993257	Aging	2023	The upregulation of circFoxp1 influences keloid by promoting cell proliferation.	hsa_circ_0001320	circFoxp1	hsa_circ_FOXP1	FOXP1	keloid	MONDO:0005348	keloid	up-regulated	RT-qPCR; RNA-seq	"circFoxp1 is up-regulated in human keloid tissues and mainly localizes to the cytoplasm. Its overexpression promotes fibroblast proliferation, migration/invasion and ECM deposition while inhibiting apoptosis, and it can aggravate keloid growth in a patient-derived xenograft nude-mouse implantation model. Mechanistically, circFoxp1 interacts with the RNA-binding protein RACK1 and is associated with inflammatory/oxidative-stress related changes."	0.7403
37993879	Journal of translational medicine	2023	A novel intronic circular RNA circFGFR1int2 up-regulates FGFR1 by recruiting transcriptional activators P65/FUS and suppressing miR-4687-5p to promote prostate cancer progression.		circFGFR1int2	hsa_circ_FGFR1	FGFR1	prostate cancer / PCa 	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; ISH	"circFGFR1int2 is up-regulated in prostate cancer and promotes tumor cell proliferation, migration, and invasion. It enhances FGFR1 expression by recruiting P65/FUS to the FGFR1 promoter to activate transcription and by sponging miR-4687-5p to relieve post-transcriptional repression of FGFR1. High circFGFR1int2 level correlates with higher grade/Gleason score/PSA and predicts worse CRPC-free survival."	0.8905
37993881	Journal of experimental & clinical cancer research : CR	2023	circ-hnRNPU inhibits NONO-mediated c-Myc transactivation and mRNA stabilization essential for glycosylation and cancer progression.	hsa_circ_0112825	circ-hnRNPU	hsa_circ_hnRNPU	hnRNPU	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Northern Blot; ISH	"circ-hnRNPU (hsa_circ_0112825), derived from hnRNPU, is down-regulated in gastric cancer and acts as a tumor suppressor. It binds NONO and promotes NONO cytoplasmic retention, which suppresses NONO-dependent c-Myc transactivation and NONO-mediated mRNA stabilization of glycosyltransferases (e.g., GALNT2/GALNT6/MGAT1), thereby inhibiting glycosylation and malignant phenotypes (growth/invasion/metastasis). Low circ-hnRNPU expression is associated with poor patient survival."	0.8866
37994157	Acta biochimica et biophysica Sinica	2023	Y-box protein-1 modulates circSPECC1 to promote glioma tumorigenesis via miR-615-5p/HIP1/AKT axis.	hsa_circ_0000745	circSPECC1	hsa_circ_SPECC1	SPECC1	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"In human glioma cell lines, circSPECC1 is upregulated and promotes proliferation, migration and invasion while inhibiting apoptosis. Mechanistically, it is regulated by YB-1 and functions as a ceRNA to sponge miR-615-5p, thereby increasing HIP1 and activating AKT signaling."	0.6578
37999558	Toxics	2023	Mechanism of Interaction between hsa_circ_0002854 and MAPK1 Protein in PM2.5-Induced Apoptosis of Human Bronchial Epithelial Cells.	hsa_circ_0002854				PM2.5-induced respiratory diseases	MONDO:0005087	respiratory system disorder	up-regulated	RT-qPCR; RNA-seq	"In PM2.5-exposed human bronchial epithelial (16HBE) cells, hsa_circ_0002854 is up-regulated and promotes apoptosis. Mechanistically, it interacts with MAPK1 and inhibits MAPK1 phosphorylation (p-ERK1), implicating MAPK signaling in PM2.5-induced apoptotic injury."	0.6793
38001611	Cancers	2023	Circular RNA from Tyrosylprotein Sulfotransferase 2 Gene Inhibits Cisplatin Sensitivity in Head and Neck Squamous Cell Carcinoma by Sponging miR-770-5p and Interacting with Nucleolin.		hsa_circ_103188 / circTPST2	hsa_circ_TPST2	TPST2	head and neck squamous cell carcinoma / HNSCC	MONDO:0010150	head and neck squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circTPST2 (hsa_circ_103188), derived from TPST2, is up-regulated in HNSCC and reduces cisplatin sensitivity. It promotes chemoresistance by sponging miR-770-5p and physically interacting with Nucleolin, increasing Nucleolin expression and suppressing apoptosis/DNA damage under cisplatin treatment. High circTPST2 expression is associated with worse overall survival in chemotherapeutic HNSCC cohorts."	0.8769
38003316	International journal of molecular sciences	2023	Analysis of ANRIL Isoforms and Key Genes in Patients with Severe Coronary Artery Disease.		Circular ANRIL / circANRIL	hsa_circ_CDKN2B-AS1	CDKN2B-AS1	coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	unknown	RT-qPCR	"In severe CAD patients, circular ANRIL (circANRIL) expression is associated with lower oxidative stress. The paper discusses circANRIL as an atheroprotective isoform, potentially acting via rRNA maturation regulation and microRNA sponging."	0.2995
38006726	Brazilian journal of otorhinolaryngology	2024	Hsa_circ_0013561 promotes progression of nasopharyngeal carcinoma by activating JAK2/STAT3 signaling pathway.	hsa_circ_0013561				Nasopharyngeal Carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; ISH	"hsa_circ_0013561 is up-regulated in nasopharyngeal carcinoma and is mainly localized in the cytoplasm. Its knockdown suppresses NPC cell proliferation and migration/metastasis, inhibits EMT, promotes apoptosis and G1 arrest, and reduces JAK2/STAT3 pathway activation (lower p-JAK2 and p-STAT3)."	0.5831
38007427	BMC oral health	2023	Circ_0099630 knockdown alleviates lipopolysaccharide-induced injuries of human periodontal ligament cells through the inhibition of TLR4 by releasing miR-409-3p.	hsa_circ_0099630	circ_0099630			periodontitis	MONDO:0005076	periodontitis	up-regulated	RT-qPCR	"circ_0099630 is up-regulated in periodontal tissues from periodontitis patients and in LPS-treated HPDLCs. Its knockdown alleviates LPS-induced proliferation inhibition, apoptosis, and inflammatory cytokine release by sponging miR-409-3p to suppress TLR4 and reduce NF-kappaB pathway activation."	0.7294
38007527	Journal of translational medicine	2023	CircTENM3 inhibites tumor progression via the miR-558/RUNX3 axis in prostate cancer.	hsa_circ_0071478	circTENM3	hsa_circ_TENM3	TENM3	prostate cancer / PCa	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; Microarray	"circTENM3 (hsa_circ_0071478), derived from TENM3, is down-regulated in prostate cancer. It mainly localizes in the cytoplasm and suppresses PCa cell proliferation, migration and invasion and inhibits tumor growth by sponging miR-558 to relieve repression of RUNX3."	0.7962
38008713	Journal of experimental & clinical cancer research : CR	2023	Hsa_circ_0009092/miR-665/NLK signaling axis suppresses colorectal cancer progression via recruiting TAMs in the tumor microenvironment.	hsa_circ_0009092	circ_0009092 / circRNA_0009092	hsa_circ_OGDH	OGDH	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	"In colorectal cancer, circ_0009092 is down-regulated and acts as a tumor suppressor by inhibiting proliferation, migration, invasion and EMT, and by reducing TAM recruitment. It functions mainly as a ceRNA that sponges miR-665 to increase NLK and inhibit Wnt/beta-catenin signaling; EIF4A3 suppresses its biogenesis, and the downstream NLK/STAT3/CCL2 module influences macrophage recruitment."	0.8772
38012555	BMC cardiovascular disorders	2023	CircHIPK3 relieves vascular calcification via mediating SIRT1/PGC-1alpha/MFN2 pathway by interacting with FUS.		CircHIPK3	hsa_circ_HIPK3	HIPK3	vascular calcification	MONDO:0005311	atherosclerosis	down-regulated	RT-qPCR	"circHIPK3 is down-regulated in AS serum and in a beta-GP-induced VSMC calcification model. Its overexpression inhibits ALP activity and calcium deposition by recruiting FUS to stabilize SIRT1 mRNA and activating the SIRT1/PGC-1alpha/MFN2 pathway, thereby alleviating vascular calcification."	0.6575
38012734	Journal of experimental & clinical cancer research : CR	2023	Extracellular vesicle-packaged circBIRC6 from cancer-associated fibroblasts induce platinum resistance via SUMOylation modulation in pancreatic cancer.	hsa_circ_0053442	circBIRC6	hsa_circ_BIRC6	BIRC6	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"In PDAC, CAF-derived extracellular vesicles deliver circBIRC6 to tumor cells, increasing oxaliplatin/platinum chemoresistance. circBIRC6 binds XRCC4 and promotes SUMO1-dependent SUMOylation at XRCC4 K115, enhancing XRCC4 chromatin/nuclear localization and NHEJ DNA repair, thereby reducing DNA damage and apoptosis. High (plasma EV or tissue) circBIRC6 correlates with oxaliplatin resistance and shorter PFS, supporting its value as a predictive biomarker and therapeutic target (e.g., ASO-circBIRC6 in PDX)."	0.8941
38012808	Translational neurodegeneration	2023	N6-methyladenosine-modified circRIMS2 mediates synaptic and memory impairments by activating GluN2B ubiquitination in Alzheimer's disease.		circRIMS2	mmu_circ_RIMS2	RIMS2	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR; RNA-seq	"In APP/PS1 Alzheimer¡¯s disease mouse models, circRIMS2 is upregulated and contributes to synaptic and memory impairments. METTL3-dependent m6A modification stabilizes circRIMS2, which sponges miR-3968 to increase UBE2K, promoting GluN2B ubiquitination/degradation and synaptic dysfunction."	0.813
38015711	Aging	2023	circSLCO1B7 suppresses the malignant progression of hepatocellular carcinoma via the miR-556-3p/DAB2IP axis.	hsa_circ_0025583	circSLCO1B7 / circ_0025583	hsa_circ_SLCO1B7	SLCO1B7	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"circSLCO1B7 is down-regulated in HCC tissues and patient plasma and functions as a tumor suppressor. It mainly localizes in the cytoplasm and inhibits proliferation, migration/invasion and EMT while promoting apoptosis by sponging miR-556-3p to upregulate DAB2IP."	0.868
38021072	Journal of bone oncology	2023	Novel_circ_003686 regulates the osteogenic differentiation of MSCs in patients with myeloma bone disease through miR-142-5p/IGF1 axis.		Novel_circ_003686 / Circ_003686			multiple myeloma bone disease / MBD	MONDO:0009693	plasma cell myeloma	down-regulated	RT-qPCR	"novel_circ_003686 (circ_003686) is down-regulated in BMSCs from patients with multiple myeloma bone disease and its overexpression promotes osteogenic differentiation. Mechanistically, it sponges miR-142-5p to relieve repression of IGF1 and modulates PI3K/AKT pathway phosphorylation signals during differentiation."	0.6427
38021156	Journal of Cancer	2023	Downregulated M6A modification and expression of circRNA_103239 promoted the progression of glioma by regulating the miR-182-5p/MTSS1 signalling pathway.		circRNA_103239			glioma	MONDO:0021042	glioma	down-regulated	RT-qPCR; Microarray	"circRNA_103239 is down-regulated in glioma and functions as a tumor suppressor by inhibiting proliferation, migration, invasion and EMT. Mechanistically, it acts as a ceRNA to sponge miR-182-5p, thereby increasing MTSS1, and its expression is regulated by METTL14-mediated m6A modification; circRNA_103239 overexpression suppresses tumor growth in a cell line-derived xenograft model."	0.8487
38023219	Frontiers in oncology	2023	CircDDX17 inhibits invasive progression of pituitary adenomas by sponging miR-1279 and regulating CADM2 expression.		Circular RNA DDX17 / circDDX17	hsa_circ_DDX17	DDX17	pituitary adenomas	MONDO:0006373	pituitary gland adenoma	down-regulated	RT-qPCR	"circDDX17 is down-regulated in pituitary adenomas and acts as a tumor suppressor by inhibiting PA cell migration, invasion, and proliferation. Mechanistically, it sponges miR-1279 to de-repress CADM2, influencing invasion-associated proteins such as MMP2/9, and it suppresses xenograft tumor growth and invasion. Clinically, higher circDDX17 is associated with better PFS and shows diagnostic potential by ROC analysis."	0.8229
38023605	JHEP reports : innovation in hepatology	2023	TGFbeta-induced circLTBP2 predicts a poor prognosis in intrahepatic cholangiocarcinoma and mediates gemcitabine resistance by sponging miR-338-3p.	hsa_circ_0032603	circLTBP2	hsa_circ_LTBP2	LTBP2	intrahepatic cholangiocarcinoma / ICC	MONDO:0003210	intrahepatic cholangiocarcinoma	up-regulated	RT-qPCR; Microarray	"In iCCA, circLTBP2 is induced by TGFbeta and promotes proliferation, migration, tumour growth, and resistance to gemcitabine-induced apoptosis. It functions mainly as a miRNA sponge for miR-338-3p, increasing expression of pro-metastatic targets (e.g., SOX4, ANHAK2, FURIN, NET1). High circLTBP2 in tumour tissue and serum extracellular vesicles is associated with poorer overall survival."	0.8523
38025527	"Open medicine (Warsaw, Poland)"	2023	CircMMP11 as a prognostic biomarker mediates miR-361-3p/HMGB1 axis to accelerate malignant progression of hepatocellular carcinoma.	hsa_circ_0062558	CircMMP11	hsa_circ_MMP11	MMP11	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circMMP11 (hsa_circ_0062558) is up-regulated in HCC tissues/cell lines and promotes HCC malignant behaviors. Mechanistically, it sponges miR-361-3p to increase HMGB1, forming a circMMP11/miR-361-3p/HMGB1 axis. Clinically, high circMMP11 indicates worse prognosis and serum circMMP11 shows strong diagnostic performance for HCC."	0.7752
38028176	Oncology letters	2024	Hsa_circ_0050900 affects ferroptosis in intrahepatic cholangiocarcinoma cells by targeting hsa_miR-605_3p to regulate SLC3A2.	hsa_circ_0050900	circRNA actinin alpha 4 (ACTN4)	hsa_circ_ACTN4	ACTN4	intrahepatic cholangiocarcinoma / ICC	MONDO:0003210	intrahepatic cholangiocarcinoma	up-regulated	RT-qPCR	"In ICC cell lines, hsa_circ_0050900 is upregulated and mainly localized in the cytoplasm. It sponges hsa-miR-605-3p to upregulate SLC3A2, thereby suppressing ferroptosis and promoting proliferation and migration."	0.7551
38029383	Blood advances	2024	Functional relevance of circRNA aberrant expression in pediatric acute leukemia with KMT2A::AFF1 fusion.		circFKBP5	hsa_circ_FKBP5	FKBP5	B-cell precursor acute lymphoblastic leukemia	MONDO:0020511	precursor B-cell acute lymphoblastic leukemia	up-regulated	RT-qPCR; RNA-seq	"circFKBP5 is upregulated/ectopically expressed in KMT2A::AFF1 BCP-ALL and supports malignant cell survival. Its knockdown in KMT2A::AFF1 cell lines increases apoptosis and reduces proliferation, consistent with an oncogenic role, and it is predicted to participate in miRNA-mediated regulatory networks."	0.725
38029383	Blood advances	2024	Functional relevance of circRNA aberrant expression in pediatric acute leukemia with KMT2A::AFF1 fusion.		circKLHL2	hsa_circ_KLHL2	KLHL2	B-cell precursor acute lymphoblastic leukemia	MONDO:0020511	precursor B-cell acute lymphoblastic leukemia	up-regulated	RT-qPCR; RNA-seq	"circKLHL2 is upregulated in KMT2A::AFF1 BCP-ALL. Loss-of-function in RS4;11/SEM increases apoptosis and decreases proliferation (strongest proliferation effect among the four oncogenic circRNAs), supporting an oncogenic role and possible participation in miRNA-mediated regulatory networks."	0.725
38029383	Blood advances	2024	Functional relevance of circRNA aberrant expression in pediatric acute leukemia with KMT2A::AFF1 fusion.		circNR3C1	hsa_circ_NR3C1	NR3C1	B-cell precursor acute lymphoblastic leukemia	MONDO:0020511	precursor B-cell acute lymphoblastic leukemia	up-regulated	RT-qPCR; RNA-seq	"circNR3C1 is upregulated in KMT2A::AFF1 BCP-ALL and functions as an oncogenic circRNA in vitro. Silencing increases apoptosis and reduces proliferation, and bioinformatic predictions suggest it may act through miRNA-binding and downstream target-gene regulation."	0.725
38029383	Blood advances	2024	Functional relevance of circRNA aberrant expression in pediatric acute leukemia with KMT2A::AFF1 fusion.		circPAN3	hsa_circ_PAN3	PAN3	B-cell precursor acute lymphoblastic leukemia	MONDO:0020511	precursor B-cell acute lymphoblastic leukemia	up-regulated	RT-qPCR; RNA-seq	circPAN3 is upregulated/ectopically expressed in KMT2A::AFF1 BCP-ALL and displays oncogenic activity in vitro. Knockdown increases apoptosis and reduces proliferation; bioinformatic predictions indicate involvement in miRNA_target gene regulatory networks.	0.725
38029383	Blood advances	2024	Functional relevance of circRNA aberrant expression in pediatric acute leukemia with KMT2A::AFF1 fusion.		circAFF1	hsa_circ_AFF1	AFF1	B-cell precursor acute lymphoblastic leukemia	MONDO:0020511	precursor B-cell acute lymphoblastic leukemia	dysregulated	RT-qPCR; RNA-seq	"AFF1-derived circRNAs (notably circAFF1_A and circAFF1_B) show altered expression in KMT2A::AFF1 ALL, with circAFF1_A being heterogeneous and higher in a HOXA-high subgroup. circAFF1 is implicated in miR-128-3p_mediated regulation of KMT2A::AFF1 protein expression and may mark or contribute to distinct transcriptional subtypes of KMT2A::AFF1 ALL."	0.5135
38033864	Frontiers in cell and developmental biology	2023	Novel circular RNA circ-0002727 regulates miR-144-3p/KIF14 pathway to promote lung adenocarcinoma progression.	hsa_circ_0002727	circRNA-0002727			lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circ-0002727 is up-regulated in LUAD tissues and LUAD cell lines and functions as an oncogenic circRNA. It sponges miR-144-3p to increase KIF14 expression, thereby promoting proliferation, migration and invasion of LUAD cells."	0.6528
38040819	Scientific reports	2023	Identification of differentially expressed circRNAs in prostate cancer of different clinical stages by RNA sequencing.	hsa_circ_0005692		hsa_circ_GLIS2		prostate cancer / PCa	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005692 is significantly down-regulated in prostate cancer tissues versus BPH and was validated by qRT-PCR (with Sanger confirmation of PCR product specificity). Bioinformatic prediction suggests it may act as a ceRNA/miRNA sponge (e.g., for miR-214-3p) and potentially regulate downstream targets such as RNF8, indicating potential diagnostic biomarker value in PCa."	0.5135
38041128	Journal of experimental & clinical cancer research : CR	2023	Hedgehog-Gli1-derived exosomal circ-0011536 mediates peripheral neural remodeling in pancreatic cancer by modulating the miR-451a/VGF axis.	hsa_circ_0011536	circ-0011536	hsa_circ_PRMT5	PRMT5	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"In PDAC with activated Hedgehog/Gli1 signaling, circ-0011536 is enriched in tumor-derived exosomes and transferred to DRG cells, where it sponges miR-451a to increase VGF expression and promote neurite outgrowth/neural remodeling (PNR). Plasma exosomal circ-0011536 is elevated in patients with PNR, supporting its potential as a biomarker for PDAC-associated nerve alterations."	0.7631
38041128	Journal of experimental & clinical cancer research : CR	2023	Hedgehog-Gli1-derived exosomal circ-0011536 mediates peripheral neural remodeling in pancreatic cancer by modulating the miR-451a/VGF axis.	mmu_circ_0001261	circ-0001261			pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR	"In mouse DRG contexts, the hsa-circ-0011536 homolog mmu-circ-0001261 functions as a ceRNA that binds mmu-miR-451a to increase VGF expression, promoting neurite extension and neuronal survival. In vivo, its level in mouse plasma exosomes correlates positively with intra-tumoral nerve density in PDAC xenografts."	0.5607
38042777	Cancer cell international	2023	Circular RNA circEYA3 promotes the radiation resistance of hepatocellular carcinoma via the IGF2BP2/DTX3L axis.	hsa_circ_0007895	circEYA3	hsa_circ_EYA3	EYA3	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"In HCC treated with 125I seeds or X-ray irradiation, circEYA3 is upregulated and promotes radioresistance. It binds the RBP IGF2BP2 and enhances IGF2BP2-mediated stabilization of DTX3L mRNA, alleviating radiation-induced DNA damage and reducing apoptosis under irradiation."	0.7958
38043005	Cancer biomarkers : section A of Disease markers	2024	Evaluation of hsa_circ_0000018/let-7f-5p/ FAM96A axis in lung adenocarcinoma progression.	hsa_circ_0000018	hsa_circRNA_000541	hsa_circ_DNAJC16	DNAJC16	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR	"hsa_circ_0000018 is down-regulated in lung adenocarcinoma and functions as a tumor suppressor in vitro. It sponges let-7f-5p to relieve repression on FAM96A, thereby inhibiting proliferation, migration, and invasion of LA cells."	0.7129
38043608	Journal of advanced research	2024	CircMap4k2 reactivated by aneurysm plication alleviates residual cardiac remodeling after SVR by enhancing cardiomyocyte proliferation in post-MI mice.	mmu_circ_0000931	circMap4k2 / circ_0000931	mmu_circ_Map4k2	Map4k2	myocardial infarction / MI	MONDO:0005068	myocardial infarction	up-regulated	RT-qPCR; RNA-seq	"In post-MI mice receiving SVR, circMap4k2 is up-regulated and enhances cardiomyocyte proliferation/regeneration in the plication zone, thereby alleviating residual cardiac remodeling. Mechanistically, circMap4k2 acts as a ceRNA by sponging miR-106a-3p to de-repress Azin1."	0.8444
38044421	Molecular cancer	2023	hsa_circ_0007919 induces LIG1 transcription by binding to FOXA1/TET1 to enhance the DNA damage response and promote gemcitabine resistance in pancreatic ductal adenocarcinoma.	hsa_circ_0007919		hsa_circ_ABR	ABR	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"In gemcitabine-resistant PDAC, hsa_circ_0007919 is upregulated and promotes chemoresistance by reducing gemcitabine-induced DNA damage and apoptosis. It localizes mainly in the nucleus and enhances LIG1 transcription by recruiting FOXA1 and TET1 to the LIG1 promoter to reduce promoter methylation, thereby activating multiple DNA repair pathways."	0.8831
38045055	Acta pharmaceutica Sinica. B	2023	ADAR1 regulates vascular remodeling in hypoxic pulmonary hypertension through N1-methyladenosine modification of circCDK17.		circCDK17	hsa_circ_CDK17	CDK17	pulmonary hypertension / PH	MONDO:0005149	pulmonary hypertension	down-regulated	RT-qPCR; RNA-seq	"circCDK17 is down-regulated in the serum of PH patients. Functionally, circCDK17 suppresses hypoxia-induced PASMC proliferation and cell-cycle progression, at least partly by interacting with PCNA and restoring PCNA ubiquitination. Mechanistically, ADAR1 binds circCDK17 and decreases its stability by A-to-I editing (A5/A293) that prevents circCDK17 m1A modification."	0.8519
38045146	Heliyon	2023	Icariin promotes osteogenic differentiation through the mmu_circ_0000349/mmu-miR-138-5p/Jumonji domain-containing protein-3 axis.	mmu_circ_0000349	circ_0000349	mmu_circ_Dtnb	Dtnb	diseases related to osteogenic differentiation	MONDO:0005381	bone disorder	up-regulated	RT-qPCR; RNA-seq	"In MC3T3-E1 osteogenic differentiation, mmu_circ_0000349 is up-regulated and mainly localized in the cytoplasm. It promotes osteogenic differentiation by sponging mmu-miR-138-5p to increase JMJD3 expression, and its expression is induced by icariin."	0.9069
38046397	Molecular therapy. Nucleic acids	2023	Circular RNA circSMAD4 regulates cardiac fibrosis by targeting miR-671-5p and FGFR2 in cardiac fibroblasts.		circSMAD4	hsa_circ_SMAD4	SMAD4	cardiac fibrosis	MONDO:0004994	cardiomyopathy	up-regulated	RT-qPCR; RNA-seq	"circSMAD4 is up-regulated during cardiac fibrosis and promotes cardiac fibroblast activation/myofibroblast differentiation. It functions as a miRNA sponge for miR-671-5p, thereby increasing FGFR2 expression and driving fibrotic remodeling; silencing circSmad4 reduces fibrosis in ISP- and TAC-induced mouse models."	0.8072
38046397	Molecular therapy. Nucleic acids	2023	Circular RNA circSMAD4 regulates cardiac fibrosis by targeting miR-671-5p and FGFR2 in cardiac fibroblasts.		circSMAD4	mmu_circ_SMAD4	SMAD4	cardiac fibrosis	MONDO:0004994	cardiomyopathy	up-regulated	RT-qPCR; RNA-seq	"circSMAD4 is up-regulated during cardiac fibrosis and promotes cardiac fibroblast activation/myofibroblast differentiation. It functions as a miRNA sponge for miR-671-5p, thereby increasing FGFR2 expression and driving fibrotic remodeling; silencing circSmad4 reduces fibrosis in ISP- and TAC-induced mouse models."	0.8072
38049555	British journal of cancer	2024	Characterisation of FLT3 alterations in childhood acute lymphoblastic leukaemia.		rt-circURAD-FLT3 / rt-circRNAs URAD::FLT3	hsa_circ_URAD-FLT3		acute lymphoblastic leukaemia / ALL	MONDO:0004967	acute lymphoblastic leukemia	unknown	RT-qPCR; RNA-seq	"This study identifies FLT3-involving read-through circRNAs (rt-circURAD-FLT3/URAD::FLT3) in childhood ALL and validates their circular junctions. Presence of rt-circURAD-FLT3 correlates with higher FLT3 and URAD gene expression and is enriched in patients with high-risk markers, suggesting potential utility as a marker of FLT3 overexpression."	0.5193
38049814	Journal of experimental & clinical cancer research : CR	2023	Circular RNA circATP9A promotes non-small cell lung cancer progression by interacting with HuR and by promoting extracellular vesicles-mediated macrophage M2 polarization.		hsa_circ_000823 / circATP9A	hsa_circ_ATP9A	ATP9A	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circATP9A is up-regulated in NSCLC and promotes proliferation, migration/invasion, tumor growth and metastasis. Mechanistically, it binds the RBP HuR to increase NUCKS1 mRNA/protein and activate PI3K/AKT/mTOR signaling, and it is packaged into extracellular vesicles via hnRNPA2B1 to drive TAM M2 polarization, promoting NSCLC progression."	0.8446
38049827	Journal of translational medicine	2023	ND630 controls ACACA and lipid reprogramming in prostate cancer by regulating the expression of circKIF18B_003.		circKIF18B_003 / CircKIF18B 003	hsa_circ_KIF18B	KIF18B	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circKIF18B_003 is up-regulated in prostate cancer and mainly localizes in the cytoplasm. It promotes PCa cell proliferation, migration, invasion, and lipid metabolic reprogramming by sponging miR-370-3p to upregulate ACACA, and its high expression is associated with worse biochemical recurrence outcome."	0.8912
38050241	Medicine	2023	Hsa_circ_0124554 may serve as a biomarker for the diagnosis of colorectal cancer: An observational study.	hsa_circ_0124554		hsa_circ_FOXO1		colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"This study shows hsa_circ_0124554 is up-regulated in colorectal cancer tissues and plasma measured by RT-qPCR, and it has moderate diagnostic performance by ROC analysis. Combining hsa_circ_0124554 with CEA and CA19-9 improves diagnostic accuracy, supporting its potential as a CRC biomarker."	0.4187
38051045	Journal of virology	2023	Hsa_circ_0007321 regulates Zika virus replication through miR-492/NFKBID/NF-kappaB signaling pathway.	hsa_circ_0007321		hsa_circ_DIS3L2	DIS3L2	Zika virus infection / ZIKV infection	MONDO:0018661	Zika virus infectious disease	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0007321 (from DIS3L2) is down-regulated after ZIKV infection and mainly localizes to the cytoplasm. It functions as a ceRNA sponge for miR-492, thereby affecting NFKBID and modulating NF-kappaB activation and inflammatory cytokines (IL-6/IL-8) to restrict ZIKV replication."	0.7884
38051045	Journal of virology	2023	Hsa_circ_0007321 regulates Zika virus replication through miR-492/NFKBID/NF-kappaB signaling pathway.	hsa_circ_0004844				Zika virus infection / ZIKV infection	MONDO:0018661	Zika virus infectious disease	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0004844 is reported as significantly up-regulated in ZIKV-infected A549 cells (RNA-seq and RT-qPCR), but no downstream mechanism or functional assays were described for this circRNA."	0.1904
38051045	Journal of virology	2023	Hsa_circ_0007321 regulates Zika virus replication through miR-492/NFKBID/NF-kappaB signaling pathway.	hsa_circ_0000290				Zika virus infection / ZIKV infection	MONDO:0018661	Zika virus infectious disease	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000290 is reported as significantly up-regulated in ZIKV-infected A549 cells (RNA-seq and RT-qPCR), but no downstream mechanism or functional assays were described for this circRNA."	0.1904
38051045	Journal of virology	2023	Hsa_circ_0007321 regulates Zika virus replication through miR-492/NFKBID/NF-kappaB signaling pathway.	hsa_circ_0001613				Zika virus infection / ZIKV infection	MONDO:0018661	Zika virus infectious disease	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001613 is reported as significantly down-regulated in ZIKV-infected A549 cells (RNA-seq and RT-qPCR), but no downstream mechanism or functional assays were described for this circRNA."	0.1904
38051045	Journal of virology	2023	Hsa_circ_0007321 regulates Zika virus replication through miR-492/NFKBID/NF-kappaB signaling pathway.	hsa_circ_0004751				Zika virus infection / ZIKV infection	MONDO:0018661	Zika virus infectious disease	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0004751 is reported as significantly down-regulated in ZIKV-infected A549 cells (RNA-seq and RT-qPCR), but no downstream mechanism or functional assays were described for this circRNA."	0.1904
38051653	Neuroreport	2024	In-depth analyses of lncRNA and circRNA expression in the hippocampus of LPS-induced AD mice by Byu d Mar 25.	mmu_circ_0000894	circ_0000894			Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR; Microarray	"mmu_circ_0000894 was down-regulated in hippocampus of BM25-treated LPS-induced AD mice compared with AD+NS controls. The study predicted that mmu_circ_0000894 may bind miR-153-5P, linking it to potential regulation of APP via a putative circRNA_miRNA interaction."	0.4997
38051653	Neuroreport	2024	In-depth analyses of lncRNA and circRNA expression in the hippocampus of LPS-induced AD mice by Byu d Mar 25.	mmu_circ_0000917	circ_0000917			Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR; Microarray	mmu_circ_0000917 was identified as a differentially expressed circRNA and was down-regulated in hippocampus of BM25-treated LPS-induced AD mice compared with AD+NS controls. The study further provided only in-silico miRNA-binding predictions for this circRNA without experimentally validated targets.	0.4997
38051653	Neuroreport	2024	In-depth analyses of lncRNA and circRNA expression in the hippocampus of LPS-induced AD mice by Byu d Mar 25.	mmu_circ_0000945	circ_0000945			Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR; Microarray	mmu_circ_0000945 was identified as a differentially expressed circRNA and was down-regulated in hippocampus of BM25-treated LPS-induced AD mice compared with AD+NS controls. The study reported predicted miRNA-binding partners for this circRNA but did not experimentally validate downstream targets or functions.	0.4997
38051653	Neuroreport	2024	In-depth analyses of lncRNA and circRNA expression in the hippocampus of LPS-induced AD mice by Byu d Mar 25.	mmu_circ_0001805	circ_0001805			Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR; Microarray	"mmu_circ_0001805 was identified as a differentially expressed circRNA and was up-regulated in hippocampus of BM25-treated LPS-induced AD mice compared with AD+NS controls. The paper reported only computational predictions of miRNAs that might bind to this circRNA, without experimental mechanistic validation."	0.4997
38053070	Molecular cancer	2023	Significant CircRNAs in liver cancer stem cell exosomes: mediator of malignant propagation in liver cancer?	hsa_circ_0004907	circ-ZEB1	hsa_circ_ZEB1	ZEB1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ-ZEB1 (hsa_circ_0004907) is enriched in liver CSC-derived exosomes and is up-regulated in HCC tumor tissues versus matched paraneoplastic tissues. It is reported as associated with stemness/poor prognosis and included in a ceRNA network analysis, but in vivo overexpression did not significantly alter xenograft tumor growth in the described experiments."	0.6616
38053070	Molecular cancer	2023	Significant CircRNAs in liver cancer stem cell exosomes: mediator of malignant propagation in liver cancer?	hsa_circ_0069152	circ-AFAP1	hsa_circ_AFAP1	AFAP1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ-AFAP1 (hsa_circ_0069152), derived from liver CSC exosomes, is up-regulated in HCC tumor tissues and associated with stemness features and poor prognosis. Functionally, circ-AFAP1 overexpression increases xenograft tumor volume and modulates stemness/EMT markers (e.g., increased CD133 with decreased E-cadherin and EpCAM), supporting a role in promoting HCC progression via enhancing stemness and EMT."	0.6616
38057879	Journal of experimental & clinical cancer research : CR	2023	CircGPRC5A enhances colorectal cancer progress by stabilizing PPP1CA and inducing YAP dephosphorylation.	hsa_circ_0025506	CircGPRC5A / hsa_circRNA_101017	hsa_circ_GPRC5A	GPRC5A	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; Microarray	"CircGPRC5A is upregulated in colorectal cancer and promotes proliferation, migration/invasion, and metastasis. It binds PPP1CA and blocks UBA1_PPP1CA interaction to reduce PPP1CA ubiquitin-mediated proteasomal degradation, increasing PPP1CA protein and driving YAP dephosphorylation (Ser127/Ser109) and pro-tumor YAP nuclear activity."	0.8585
38064496	PloS one	2023	Bioinformatics analysis-based screening of circRNA gene with mainstream expression trend in colorectal cancer and construction of a coexpression regulatory network.	hsa_circ_0005927		hsa_circ_VDAC3	VDAC3	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	Microarray	"HAS-circ-0005927 (host gene VDAC3) is identified by GEO microarray mining as a down-regulated circRNA in colorectal cancer and is proposed as a potential diagnostic marker, without experimental mechanistic validation in this study."	0.1768
38064496	PloS one	2023	Bioinformatics analysis-based screening of circRNA gene with mainstream expression trend in colorectal cancer and construction of a coexpression regulatory network.	hsa_circ_0065173		hsa_circ_SETD2	SETD2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	Microarray	"HAS-circ-0065173 (host gene SETD2) is identified as down-regulated in CRC by GEO microarray bioinformatics and suggested as a potential diagnostic circRNA, without direct experimental validation in this paper."	0.1768
38064496	PloS one	2023	Bioinformatics analysis-based screening of circRNA gene with mainstream expression trend in colorectal cancer and construction of a coexpression regulatory network.	hsa_circ_0006174		hsa_circ_RAD23B	RAD23B	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	Microarray	"HAS-circ-0006174 (host gene RAD23B) is an up-regulated circRNA in CRC identified by microarray/bioinformatics and proposed as a potential diagnostic marker, with no direct functional/mechanistic experiments reported for this circRNA."	0.1768
38064496	PloS one	2023	Bioinformatics analysis-based screening of circRNA gene with mainstream expression trend in colorectal cancer and construction of a coexpression regulatory network.	hsa_circ_0000518		hsa_circ_RPPH1	RPPH1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	Microarray	HAS-circ-0000518 (host gene RPPH1) is predicted by GEO dataset mining to be up-regulated in CRC and is suggested as a potential diagnostic circRNA; no direct mechanistic axis is experimentally validated for this circRNA in the paper.	0.1768
38064496	PloS one	2023	Bioinformatics analysis-based screening of circRNA gene with mainstream expression trend in colorectal cancer and construction of a coexpression regulatory network.	hsa_circ_0006332		hsa_circ_MYBL2	MYBL2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	Microarray	HAS-circ-0006332 (host gene MYBL2) is identified as up-regulated in CRC through GEO microarray bioinformatics and suggested as a potential diagnostic marker; the study does not provide direct experimental validation of its downstream miRNA/mRNA targets.	0.1768
38064496	PloS one	2023	Bioinformatics analysis-based screening of circRNA gene with mainstream expression trend in colorectal cancer and construction of a coexpression regulatory network.	hsa_circ_0087862				colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	Microarray	"The study proposes a ceRNA axis where up-regulated has-circ-0087862 binds miR-892b and thereby relieves translational inhibition on CCND1, increasing CCND1 expression in CRC; this is based on bioinformatic network construction rather than direct experimental validation for this circRNA."	0.1768
38067260	Cancers	2023	Circular RNA CDR1as Mediated by Human Antigen R (HuR) Promotes Gastric Cancer Growth via miR-299-3p/TGIF1 Axis.		CDR1as (ciRS-7) / CDR1as	hsa_circ_CDR1	CDR1	Gastric cancer / GC	MONDO:0001056	gastric cancer	unknown	RT-qPCR	"In gastric cancer, CDR1as functions as an oncogenic circRNA that enhances proliferation/viability and suppresses apoptosis in vitro and in cell line-derived xenograft tumors. Mechanistically, it acts as a ceRNA sponging miR-299-3p to de-repress TGIF1, while the RBP HuR binds CDR1as and increases its level, strengthening the HuR/CDR1as/miR-299-3p/TGIF1 axis."	0.7456
38073586	Clinical and translational medicine	2023	circRARS synergises with IGF2BP3 to regulate RNA methylation recognition to promote tumour progression in renal cell carcinoma.	hsa_circ_0001550	circRARS	hsa_circ_RARS1	RARS1	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR	"circRARS (hsa_circ_0001550) is up-regulated in RCC and acts as an oncogenic circRNA. It binds IGF2BP3 (KH1_KH2) to enhance IGF2BP3 m6A-site recognition, recruits stabiliser proteins, and increases stability/translation of CAPN15, CD44, HMGA2, TNRC6A and ZMIZ2, promoting tumour progression, lipid accumulation and sunitinib resistance."	0.8661
38075197	Non-coding RNA research	2024	Bioinformatic analysis shows the correlation of hsa_circ_0006220-miR-221/222-3p-ESR1/KDR axis with sorafenib resistance of hepatocellular carcinoma.	hsa_circ_0006220		hsa_circ_TADA2A	TADA2A	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	Microarray	"Using circRNA microarray data (GSE101850) and downstream database analyses, hsa_circ_0006220 was identified as down-regulated in sorafenib-resistant vs sorafenib-sensitive HCC samples. The study proposes a putative regulatory axis in which hsa_circ_0006220 interacts with miR-221-3p/miR-222-3p and relates to ESR1 and KDR in sorafenib resistance, without experimental functional validation."	0.459
38077483	"Diabetes, metabolic syndrome and obesity : targets and therapy"	2023	Microarray Expression Profile of Exosomal circRNAs from High Glucose Stimulated Human Renal Tubular Epithelial Cells.	hsa_circ_0009885	circ_0009885	hsa_circ_PLOD1	PLOD1	diabetic kidney disease / DKD	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR; Microarray	"Exosomal circ_0009885 is up-regulated in exosomes from high glucose-stimulated HK-2 cells. Knockdown of circ_0009885 reverses high glucose-induced increases of inflammatory/ECM markers (CCL2, IL6, fibronetin), implicating it in DKD-related inflammation and EMT changes."	0.3213
38077483	"Diabetes, metabolic syndrome and obesity : targets and therapy"	2023	Microarray Expression Profile of Exosomal circRNAs from High Glucose Stimulated Human Renal Tubular Epithelial Cells.	hsa_circ_0043753	circ_0043753	hsa_circ_NKIRAS2	NKIRAS2	diabetic kidney disease / DKD	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR; Microarray	"Exosomal circ_0043753 is up-regulated in exosomes from high glucose-stimulated HK-2 cells. Silencing circ_0043753 reverses high glucose-associated epcam reduction, linking it to EMT-related changes relevant to DKD."	0.3213
38077483	"Diabetes, metabolic syndrome and obesity : targets and therapy"	2023	Microarray Expression Profile of Exosomal circRNAs from High Glucose Stimulated Human Renal Tubular Epithelial Cells.	hsa_circ_0011760	circ_0011760	hsa_circ_FHL3	FHL3	diabetic kidney disease / DKD	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR; Microarray	"Exosomal circ_0011760 is up-regulated in exosomes from high glucose-stimulated HK-2 cells. Silencing circ_0011760 reverses high glucose-induced increases in IL6 and fibronetin, supporting a role in DKD-relevant inflammation and EMT-associated remodeling."	0.3213
38077483	"Diabetes, metabolic syndrome and obesity : targets and therapy"	2023	Microarray Expression Profile of Exosomal circRNAs from High Glucose Stimulated Human Renal Tubular Epithelial Cells.	hsa_circ_0032872	circ_0032872	hsa_circ_EML5	EML5	diabetic kidney disease / DKD	MONDO:0005016	diabetic kidney disease	down-regulated	RT-qPCR; Microarray	"Exosomal circ_0032872 is down-regulated in exosomes from high glucose-stimulated HK-2 cells. Overexpression of circ_0032872 reverses high glucose-induced IL6 upregulation, suggesting an anti-inflammatory role relevant to DKD-associated tubular injury."	0.3213
38077483	"Diabetes, metabolic syndrome and obesity : targets and therapy"	2023	Microarray Expression Profile of Exosomal circRNAs from High Glucose Stimulated Human Renal Tubular Epithelial Cells.	hsa_circ_0004716	circ_0004716	hsa_circ_WIPI1	WIPI1	diabetic kidney disease / DKD	MONDO:0005016	diabetic kidney disease	down-regulated	RT-qPCR; Microarray	"Exosomal circ_0004716 is down-regulated in exosomes from high glucose-stimulated HK-2 cells. Overexpression of circ_0004716 reverses high glucose-induced increases in CCL2 and n cadherin, indicating involvement in inflammation and EMT-related phenotypes relevant to DKD."	0.3213
38077483	"Diabetes, metabolic syndrome and obesity : targets and therapy"	2023	Microarray Expression Profile of Exosomal circRNAs from High Glucose Stimulated Human Renal Tubular Epithelial Cells.	hsa_circ_0009445	circ_0009445	hsa_circ_NPHP4	NPHP4	diabetic kidney disease / DKD	MONDO:0005016	diabetic kidney disease	down-regulated	RT-qPCR; Microarray	"Exosomal circ_0009445 is down-regulated in exosomes from high glucose-stimulated HK-2 cells and validated by RT-qPCR, but its functional role was not tested due to unsuccessful overexpression plasmid construction."	0.1904
38079253	DNA and cell biology	2024	Circular RNA circXPO1 Promotes Multiple Myeloma Progression by Regulating miR-495-3p/DNA Damage-Induced Transcription 4 Axis.		hsa_circRNA_102735 / circXPO1	hsa_circ_XPO1	XPO1	multiple myeloma / MM	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR; Microarray	"circXPO1 is up-regulated in multiple myeloma bone marrow and MM cell lines and is associated with worse survival. Functionally, circXPO1 promotes proliferation and cell-cycle progression and inhibits apoptosis, at least partly by sponging miR-495-3p to upregulate DDIT4, and its silencing suppresses xenograft tumor growth."	0.8718
38081815	Cell death discovery	2023	Circular RNA hsa_circ_0001846 facilitates the malignant behaviors of pancreatic cancer by sponging miR-204-3p and upregulating KRAS expression.	hsa_circ_0001846		hsa_circ_UBAP2	UBAP2	pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"hsa_circ_0001846 (UBAP2-derived) is up-regulated in pancreatic cancer tissues and cell lines and promotes proliferation, migration, invasion, and xenograft growth. Mechanistically, it functions as a ceRNA by sponging miR-204-3p, thereby relieving repression of KRAS and enhancing KRAS expression, suggesting biomarker potential in PC."	0.7663
38082189	Molecular biotechnology	2024	Circular RNA circRANGAP1/miR-512-5p/SOD2 Axis Regulates Cell Proliferation and Migration in Non-small Cell Lung Cancer (NSCLC).	hsa_circ_0001235	CircRANGAP1	hsa_circ_RANGAP1	RANGAP1	Non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circRANGAP1 is upregulated in NSCLC tissues/cells and promotes proliferation, migration, and xenograft tumor growth. Mechanistically, it acts as a ceRNA to sponge miR-512-5p, thereby increasing SOD2 expression and contributing to NSCLC progression; high circRANGAP1 predicts worse overall survival."	0.7855
38086834	Scientific reports	2023	Construction of a ceRNA regulatory network to explore potential pathogenesis mechanisms involved in human hepatocellular carcinoma.	hsa_circ_0079875				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	dysregulated	RT-qPCR; Microarray	hsa_circ_0079875 was one of five statistically significant circRNAs in HCC tissues (tumor vs adjacent normal) validated by qRT-PCR and then included for downstream bioinformatic prediction to build circRNA_miRNA_mRNA ceRNA networks. No specific miRNA/mRNA axis or functional mechanism was reported for hsa_circ_0079875 in the final selected prognostic axes.	0.4032
38086834	Scientific reports	2023	Construction of a ceRNA regulatory network to explore potential pathogenesis mechanisms involved in human hepatocellular carcinoma.	hsa_circ_0091580				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	dysregulated	RT-qPCR; Microarray	"hsa_circ_0091580 was differentially expressed in HCC tissues and validated by qRT-PCR in a 34-patient cohort. The study predicted a ceRNA mechanistic axis hsa_circ_0091580/miR-1179/AP3B1 that was reported to correlate negatively with HCC prognosis, but the interactions were not experimentally validated beyond expression testing and bioinformatic prediction."	0.4032
38086834	Scientific reports	2023	Construction of a ceRNA regulatory network to explore potential pathogenesis mechanisms involved in human hepatocellular carcinoma.	hsa_circ_0091581				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	dysregulated	RT-qPCR; Microarray	"hsa_circ_0091581 was differentially expressed in HCC tissues and validated by qRT-PCR. The study proposed a prognostically relevant ceRNA axis hsa_circ_0091581/miR-1179/AP3B1 derived from database-based interaction prediction and ceRNA network construction, without additional mechanistic wet-lab validation."	0.4032
38086834	Scientific reports	2023	Construction of a ceRNA regulatory network to explore potential pathogenesis mechanisms involved in human hepatocellular carcinoma.	hsa_circ_0004788				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	dysregulated	RT-qPCR; Microarray	hsa_circ_0004788 was one of five statistically significant circRNAs in HCC validated by qRT-PCR and included for downstream ceRNA network construction via database prediction. The paper did not report a specific circRNA_miRNA_mRNA prognostic axis for hsa_circ_0004788.	0.4032
38086834	Scientific reports	2023	Construction of a ceRNA regulatory network to explore potential pathogenesis mechanisms involved in human hepatocellular carcinoma.	hsa_circ_0059730				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	dysregulated	RT-qPCR; Microarray	"hsa_circ_0059730 was differentially expressed in HCC and validated by qRT-PCR in clinical tissues. The paper proposed three prognostically relevant ceRNA axes involving hsa_circ_0059730 (with miR-516a-5p/ADSL, miR-378g/TRNP1, and miR-515-5p/MAPRE1), derived from bioinformatic prediction and ceRNA network construction without direct interaction assays."	0.4032
38087322	Molecular cancer	2023	A positive feedback circuit driven by m6A-modified circular RNA facilitates colorectal cancer liver metastasis.		circ-YAP / circYAP	hsa_circ_YAP	YAP	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circ-YAP is upregulated in CRC with liver metastasis and predicts worse survival. It promotes migration/invasion and liver metastasis by m6A-dependent translation into YAP-220aa, which binds LATS1 to activate YAP nuclear signaling, and YAP/TEAD further enhances circ-YAP transcription to form a positive feedback loop."	0.9003
38087801	Thoracic cancer	2024	Tumor-related exosomal circ_0001715 promotes lung adenocarcinoma cell proliferation and metastasis via enhancing M2 macrophage polarization by regulating triggering receptor expressed on myeloid cells-2.	hsa_circ_0001715	circ_0001715			lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"In LUAD cell_macrophage coculture, tumor-derived exosomal circ_0001715 promotes M2 macrophage polarization and thereby enhances LUAD cell proliferation, migration, and invasion/metastasis. Mechanistically, circ_0001715 sponges miR-205-5p to de-repress/positively regulate TREM2, and TREM2 is required for the exosomal circ_0001715 effects."	0.5634
38090284	Journal of thoracic disease	2023	CircRNA ARHGAP10 promotes osteogenic differentiation through the miR-335-3p/RUNX2 pathway in aortic valve calcification.	hsa_circ_0007265	circRNA ARHGAP10 / circARHGAP10	hsa_circ_ARHGAP10	ARHGAP10	calcific aortic valve disease / CAVD	MONDO:0005463	aortic valve calcification	up-regulated	RT-qPCR; Microarray	"circARHGAP10 (hsa_circ_0007265) is up-regulated in calcified aortic valve tissue and promotes VIC osteogenic differentiation/calcification. It functions as a ceRNA that sponges miR-335-3p, thereby increasing RUNX2 expression, with in vitro assays and ApoE_/_ CAVD model validation."	0.7978
38093288	Molecular cancer	2023	Hsa_circ_0136666 stimulates gastric cancer progression and tumor immune escape by regulating the miR-375/PRKDC Axis and PD-L1 phosphorylation.	hsa_circ_0136666	circPRKDC	hsa_circ_PRKDC	PRKDC	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; ISH; Microarray	"hsa_circ_0136666 is upregulated in gastric cancer tissues/cells and promotes proliferation and immune escape. It functions mainly as a ceRNA by sponging miR-375-3p to increase PRKDC (DNA-PK), which stabilizes PD-L1 via phosphorylation, contributing to an immunosuppressive tumor microenvironment and reduced CD8+ T-cell antitumor activity. Targeting hsa_circ_0136666 with LNP-siRNA can enhance anti-PD-L1 therapeutic efficacy in mouse tumor models."	0.8225
38097567	Cell death discovery	2023	"A novel circular RNA, circMAML3, promotes tumor progression of prostate cancer by regulating miR-665/MAPK8IP2 axis."	hsa_circ_0125392	circMAML3	hsa_circ_MAML3	MAML3	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circMAML3 is up-regulated in prostate cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes proliferation and metastatic phenotypes by sponging miR-665, thereby upregulating MAPK8IP2; knockdown suppresses tumor growth in a PC3 xenograft model."	0.8726
38098098	Clinical epigenetics	2023	Transcriptome-wide map of N6-methyladenosine (m6A) profiling in coronary artery disease (CAD) with clopidogrel resistance.	hsa_circ_0070675	hsa_circ_0070675_CBC1			coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR; RNA-seq	"This circRNA is upregulated in PBMCs from CAD patients with clopidogrel resistance compared with non-CR controls and was validated by RT-qPCR, suggesting it may serve as a CR-related biomarker."	0.3588
38098098	Clinical epigenetics	2023	Transcriptome-wide map of N6-methyladenosine (m6A) profiling in coronary artery disease (CAD) with clopidogrel resistance.		hsa-circRNA13011-5_CBC1			coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR; RNA-seq	"This circRNA is upregulated in PBMCs from CAD patients with clopidogrel resistance and was validated by RT-qPCR, indicating potential value as a CR-related biomarker."	0.3588
38098098	Clinical epigenetics	2023	Transcriptome-wide map of N6-methyladenosine (m6A) profiling in coronary artery disease (CAD) with clopidogrel resistance.		hsa-circRNA6406-3_CBC1			coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR; RNA-seq	"This circRNA is upregulated in PBMCs from clopidogrel-resistant CAD patients versus non-CR controls and is presented as part of a set of potential CR-related biomarkers, with RT-qPCR validation."	0.3588
38098098	Clinical epigenetics	2023	Transcriptome-wide map of N6-methyladenosine (m6A) profiling in coronary artery disease (CAD) with clopidogrel resistance.	hsa_circ_0082972	hsa_circ_0082972_CBC1			coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	down-regulated	RT-qPCR; RNA-seq	"This circRNA is downregulated in PBMCs from CAD patients with clopidogrel resistance versus non-CR controls and was validated by RT-qPCR, suggesting potential relevance as a CR-related biomarker."	0.3588
38098508	Frontiers in oncology	2023	Serum exosomal circCCDC66 as a potential diagnostic and prognostic biomarker for pituitary adenomas.	hsa_circ_0001313	circCCDC66 / circ_0001313	hsa_circ_CCDC66	CCDC66	pituitary adenoma / PA	MONDO:0006373	pituitary gland adenoma	up-regulated	RT-qPCR	"Serum exosomal circCCDC66 is significantly up-regulated in pituitary adenoma patients and correlates with tumor status over time. It shows diagnostic value by ROC analysis and prognostic value, where higher levels indicate shorter progression-free survival."	0.5339
38099281	"Neurobiology of pain (Cambridge, Mass.)"	2023	circRNA landscape in dorsal root ganglia from mice with collagen antibody-induced arthritis.		circNufip1 / mmu_circRNA_27816	mmu_circ_Nufip1	Nufip1	arthritis	MONDO:0005578	arthritic joint disease	up-regulated	RT-qPCR; Microarray	"circNufip1 is increased in DRG in the late phase of CAIA and was validated by qPCR. Bioinformatic prediction suggests it may act via miRNA-associated pathways related to NMDA receptor unblocking and synaptic processes, potentially contributing to persistent mechanical hypersensitivity/sensitization."	0.5922
38099281	"Neurobiology of pain (Cambridge, Mass.)"	2023	circRNA landscape in dorsal root ganglia from mice with collagen antibody-induced arthritis.		circVps13 / mmu_circRNA_44535	mmu_circ_Vps13c	Vps13c	arthritis	MONDO:0005578	arthritic joint disease	up-regulated	RT-qPCR	"circVps13/circVps13c is upregulated in DRG during the inflammatory phase of CAIA (qPCR). miRWalk/Reactome predictions from its miRNA binding set suggest links to signaling terms including PI3K/AKT, RAF/MAPK and immune/inflammation-related processes."	0.5545
38099281	"Neurobiology of pain (Cambridge, Mass.)"	2023	circRNA landscape in dorsal root ganglia from mice with collagen antibody-induced arthritis.		circMicall1 / mmu_circRNA_011505	mmu_circ_Micall1	Micall1	arthritis	MONDO:0005578	arthritic joint disease	up-regulated	RT-qPCR	circMicall1 is upregulated in DRG during the inflammatory phase of CAIA (qPCR). Bioinformatic analysis of its predicted miRNA binding partners suggests links to clathrin-mediated endocytosis and other signaling terms.	0.5545
38102461	Cancer gene therapy	2024	Hsa_circ_0013561 promotes epithelial-mesenchymal transition and tumor progression by regulating ANXA2 via miR-23b-3p in ovarian cancer.	hsa_circ_0013561	hsa_circSLC16A1_004 / circ-0013561	hsa_circ_SLC16A1	SLC16A1	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; ISH	"hsa_circ_0013561 is up-regulated in ovarian cancer tissues/cells (highest in metastatic tissues) and promotes proliferation, migration/invasion, tumor growth, metastasis and EMT. Mechanistically, it functions as a ceRNA by binding miR-23b-3p to increase ANXA2 expression, driving EMT and tumor progression."	0.7981
38102848	Journal of cellular and molecular medicine	2024	Macrophages enhance cisplatin resistance in gastric cancer through the transfer of circTEX2.	hsa_circ_0006479	CircTEX2 / circ_TEX2	hsa_circ_TEX2	TEX2	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circTEX2 is enriched in M2 macrophages and their exosomes and is delivered to gastric cancer cells. It acts as a ceRNA sponge for miR-145, increasing ABCC1 expression and thereby promoting cisplatin resistance and reducing cisplatin-induced apoptosis; silencing circTEX2 or disrupting the miR-145/ABCC1 arm restores cisplatin sensitivity."	0.8331
38105235	Cellular & molecular biology letters	2023	CircZNF609 regulates pulmonary fibrosis via miR-145-5p/KLF4 axis and its translation function.		circZNF609	mmu_circ_Znf609	ZNF609	pulmonary fibrosis	MONDO:0002771	pulmonary fibrosis	down-regulated	RT-qPCR; ISH	"circZNF609 is down-regulated during fibroblast activation and in silica-induced fibrotic lungs. Its overexpression suppresses fibroblast activation/proliferation and alleviates silica-induced pulmonary fibrosis. Mechanistically, it inhibits fibrosis through a miR-145-5p/KLF4 ceRNA axis and through translation into anti-fibrotic peptides, with m6A modification regulating its expression and export."	0.7951
38105907	Pharmacogenomics and personalized medicine	2023	Circ_0000140 Alters miR-527/SLC7A11-Mediated Ferroptosis to Influence Oral Squamous Cell Carcinoma Cell Resistance to DDP.	hsa_circ_0000140	circ_0000140	hsa_circ_KIAA0907	KIAA0907	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circ_0000140 is up-regulated in DDP-resistant OSCC tumors and resistant cell lines, where it promotes cisplatin resistance by inhibiting ferroptosis. Mechanistically, it sponges miR-527 to relieve repression of SLC7A11, increasing SLC7A11 and reducing ferroptotic activity, thereby elevating DDP IC50."	0.788
38124119	Stem cell research & therapy	2023	Competing endogenous RNA network analysis of Turner syndrome patient-specific iPSC-derived cardiomyocytes reveals dysregulation of autosomal heart development genes by altered dosages of X-inactivation escaping non-coding RNAs.	hsa_circ_0090421		hsa_circ_CDK16	CDK16	Turner syndrome / TS	MONDO:0019499	Turner syndrome	dysregulated	RT-qPCR; Microarray	hsa_circ_0090421 (from the X-linked host gene CDK16) is reported as a differentially expressed circRNA in TS iPSC-derived cardiomyocytes and is included in predicted ceRNA circuits that may modulate autosomal genes involved in heart development and mitochondrial respiratory chain function.	0.4032
38124119	Stem cell research & therapy	2023	Competing endogenous RNA network analysis of Turner syndrome patient-specific iPSC-derived cardiomyocytes reveals dysregulation of autosomal heart development genes by altered dosages of X-inactivation escaping non-coding RNAs.	hsa_circ_0090392		hsa_circ_UBA1	UBA1	Turner syndrome / TS	MONDO:0019499	Turner syndrome	dysregulated	RT-qPCR; Microarray	hsa_circ_0090392 (from the X-linked host gene UBA1) is a TS-associated circRNA included in predicted ceRNA circuits that may influence autosomal gene dysregulation related to heart development and mitochondrial respiratory chain function in TS cardiomyocytes.	0.4032
38125536	Heliyon	2023	"WASF3 overexpression affects the expression of circular RNA hsa-circ-0100153, which promotes breast cancer progression by sponging hsa-miR-31, hsa-miR-767-3p, and hsa-miR-935."	hsa_circ_0100153		hsa_circ_WASF3	WASF3	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RNA-seq	"hsa-circ-0100153 is up-regulated in breast cancer and is positively correlated with WASF3 expression. Network-based analyses suggest it promotes breast cancer progression by sponging hsa-miR-31, hsa-miR-767-3p and hsa-miR-935, and is linked to cell-cycle related functions. High hsa-circ-0100153 expression is associated with shorter overall survival."	0.459
38126999	Aging	2023	"hsa_circ_0002980 prevents proliferation, migration, invasion, and epithelial-mesenchymal transition of liver cancer cells through microRNA-1303/cell adhesion molecule 2 axis."	hsa_circ_0002980	circ_0002980			Liver cancer	MONDO:0002691	liver cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0002980 is down-regulated in liver cancer tissues and cell lines. Its overexpression suppresses liver cancer cell proliferation, migration, invasion and EMT by sponging miR-1303 and thereby de-repressing CADM2."	0.6578
38129874	Cancer cell international	2023	A RBM47 and IGF2BP1 mediated circular FNDC3B-FNDC3B mRNA imbalance is involved in the malignant processes of osteosarcoma.	hsa_circ_0067971	circFNDC3B	hsa_circ_FNDC3B	FNDC3B	osteosarcoma / OS	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR	"circFNDC3B is down-regulated in osteosarcoma and functions as a tumor suppressor, inhibiting OS cell proliferation, migration, invasion and xenograft tumor growth. Mechanistically, RBM47 promotes circFNDC3B biogenesis via binding flanking introns, and circFNDC3B competitively binds IGF2BP1 to reduce FNDC3B mRNA stability, contributing to a circular FNDC3B/FNDC3B mRNA imbalance."	0.8396
38139387	International journal of molecular sciences	2023	Identification of Differential Circular RNA Expression Profiles and Functional Networks in Human Macrophages Induced by Virulent and Avirulent Mycobacterium tuberculosis Strains.		circSOD2	hsa_circ_SOD2	SOD2	tuberculosis / TB	MONDO:0018076	tuberculosis	up-regulated	RT-qPCR; RNA-seq	circSOD2 is up-regulated in M.tb-infected THP-1 macrophages and is mainly localized in the cytoplasm. The study predicts a ceRNA axis involving circSOD2/miR-4519/MAPK1 that may be associated with M.tb infection and host defense.	0.5439
38139387	International journal of molecular sciences	2023	Identification of Differential Circular RNA Expression Profiles and Functional Networks in Human Macrophages Induced by Virulent and Avirulent Mycobacterium tuberculosis Strains.		circCHSY1	hsa_circ_CHSY1	CHSY1	tuberculosis / TB	MONDO:0018076	tuberculosis	up-regulated	RT-qPCR; RNA-seq	circCHSY1 is up-regulated in M.tb-infected THP-1 macrophages and is mainly localized in the cytoplasm. The study includes circCHSY1 in a predicted circRNA-miRNA-mRNA ceRNA network related to M.tb infection.	0.5439
38139387	International journal of molecular sciences	2023	Identification of Differential Circular RNA Expression Profiles and Functional Networks in Human Macrophages Induced by Virulent and Avirulent Mycobacterium tuberculosis Strains.		circTNFRSF21	hsa_circ_TNFRSF21	TNFRSF21	tuberculosis / TB	MONDO:0018076	tuberculosis	down-regulated	RT-qPCR; RNA-seq	circTNFRSF21 is down-regulated in M.tb-infected THP-1 macrophages and is mainly localized in the cytoplasm. The study predicts a ceRNA axis circTNFRSF21/miR-6721-5p/MYD88 that may be associated with M.tb infection.	0.5439
38139387	International journal of molecular sciences	2023	Identification of Differential Circular RNA Expression Profiles and Functional Networks in Human Macrophages Induced by Virulent and Avirulent Mycobacterium tuberculosis Strains.		circDHTKD1	hsa_circ_DHTKD1	DHTKD1	tuberculosis / TB	MONDO:0018076	tuberculosis	down-regulated	RT-qPCR; RNA-seq	circDHTKD1 is down-regulated in M.tb-infected THP-1 macrophages and is mainly localized in the cytoplasm. The study highlights a predicted ceRNA axis circDHTKD1/miR-660-3p/IL-12B potentially associated with M.tb infection.	0.5439
38145010	Journal of inflammation research	2023	RNA Sequencing and Bioinformatics Analysis to Reveal Potential Biomarkers in Patients with Combined Allergic Rhinitis and Asthma Syndrome.	hsa_circ_0007272				Combined allergic rhinitis and asthma syndrome / CARAS	MONDO:0004979	asthma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0007272 is down-regulated in CARAS (vs AR and vs healthy controls) in whole blood. It is proposed to participate in CARAS through a circRNA_mRNA regulatory relationship with CLC, within a broader lncRNA/circRNA_mRNA co-expression network."	0.4032
38145010	Journal of inflammation research	2023	RNA Sequencing and Bioinformatics Analysis to Reveal Potential Biomarkers in Patients with Combined Allergic Rhinitis and Asthma Syndrome.	hsa_circ_0070934				Combined allergic rhinitis and asthma syndrome / CARAS	MONDO:0004979	asthma	down-regulated	RNA-seq	"hsa_circ_0070934 is identified by RNA-seq as down-regulated in CARAS (vs AR and vs healthy controls) in whole blood. It is implicated in a circRNA_mRNA regulatory relationship with CLC, suggesting a potential role in CARAS-related immune/inflammatory biology."	0.1768
38145010	Journal of inflammation research	2023	RNA Sequencing and Bioinformatics Analysis to Reveal Potential Biomarkers in Patients with Combined Allergic Rhinitis and Asthma Syndrome.	hsa_circ_0008903				Combined allergic rhinitis and asthma syndrome / CARAS	MONDO:0004979	asthma	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0008903 is a CARAS-associated circRNA detected in whole blood, with RNA-seq suggesting up-regulation but RT-qPCR indicating down-regulation in CARAS vs healthy controls. The study links hsa_circ_0008903 to immune-related targets (TEC and CYSLTR2) through circRNA_mRNA regulatory pairs, suggesting involvement in CARAS pathogenesis."	0.4032
38162176	JTO clinical and research reports	2023	Brief Report: circRUNX1 as Potential Biomarker for Cancer Recurrence in EGFR Mutation-Positive Surgically Resected NSCLC.	hsa_circ_0002360	circRUNX1	hsa_circ_RUNX1	RUNX1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RNA-seq	circRUNX1 (hsa_circ_0002360) is up-regulated in tumors from relapsing versus nonrelapsing EGFR-mutant resected NSCLC patients in nCounter analysis and is associated with shorter relapse-free/disease-free survival. It is included in a random-forest-derived 6-circRNA signature predictive of recurrence.	0.6895
38163874	Biology direct	2024	Circ_MAPK9 promotes STAT3 and LDHA expression by silencing miR-642b-3p and affects the progression of hepatocellular carcinoma.	hsa_circ_0001566	circ_MAPK9	hsa_circ_MAPK9	MAPK9	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circ_MAPK9 is up-regulated in HCC and acts as an oncogenic circRNA. It sponges miR-642b-3p to de-repress STAT3 and LDHA, enhancing STAT3 activation and LDHA-associated glycolysis, thereby promoting proliferation, migration/invasion, and tumor growth while inhibiting apoptosis; high circ_MAPK9 predicts poor survival."	0.8442
38163881	Journal of experimental & clinical cancer research : CR	2024	EIF4A3-mediated biogenesis of circSTX6 promotes bladder cancer metastasis and cisplatin resistance.	hsa_circ_0007905	CircSTX6	hsa_circ_STX6	STX6	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"circSTX6 (hsa_circ_0007905), derived from STX6 and mainly localized in the cytoplasm, is up-regulated in bladder cancer tissues/cells. It promotes migration/invasion and cisplatin resistance by sponging miR-515-3p to increase SUZ12, and by binding PABPC1 to enhance SUZ12 mRNA stability; its biogenesis is promoted by EIF4A3."	0.8585
38165465	European journal of pediatrics	2024	Peripheral blood circular RNA circ-0008102 may serve as a novel clinical biomarker in beta-thalassemia patients.	hsa_circ_0008102	circ-0008102 / circ-100654	hsa_circ_LCOR	LCOR	beta-thalassemia 	MONDO:0013517	beta-thalassemia HBB/LCRB	up-regulated	RT-qPCR	"circ-0008102 (derived from LCOR) is up-regulated in peripheral blood of pediatric beta-thalassemia patients without recent transfusion and has moderate diagnostic value to distinguish this subgroup. It localizes mainly to the cytoplasm and is proposed to act as a ceRNA regulating miR-372-3p/miR-329-5p/miR-198/miR-152-5p/miR-627-3p and downstream targets, and it promotes gamma-globin expression in K562 cells."	0.7352
38166853	BMC cancer	2024	A hsa_circ_001726 axis regulated by E2F6 contributes to metastasis of hepatocellular carcinoma.		hsa_circ_001726	hsa_circ_CCT2	CCT2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"hsa_circ_001726 is up-regulated in HCC tissues/cell lines and promotes HCC malignant phenotypes and metastasis. Mechanistically, E2F6 enhances its expression via the CCT2 promoter, and hsa_circ_001726 sponges miR-671-5p to increase PRMT9, activating Notch1/Hes1-driven EMT."	0.8355
38167042	BMC musculoskeletal disorders	2024	Circ_0027885 sponges miR-203-3p to regulate RUNX2 expression and alleviates osteoporosis progression.	hsa_circ_0027885	circ_0027885			Osteoporosis / OP	MONDO:0005298	osteoporosis	down-regulated	RT-qPCR	"circ_0027885 is down-regulated in serum from osteoporosis patients and promotes osteogenic differentiation in hBMSCs. Mechanistically, it functions as a ceRNA that sponges miR-203-3p, thereby increasing RUNX2 expression and alleviating osteoporosis progression."	0.6102
38167453	Scientific reports	2024	Integrated whole transcriptome profiling revealed a convoluted circular RNA-based competing endogenous RNAs regulatory network in colorectal cancer.	hsa_circ_0001955				colorectal cancer / CRC	MONDO:0005575	colorectal cancer	unknown	Microarray	"This study¡¯s in-silico ceRNA sub-network suggests hsa_circ_0001955 may sponge hsa-miR-150-5p and thereby influence survival-related hub genes (e.g., MYC, CCNA2, RACGAP1, CD44) in colorectal cancer. The work proposes biomarker potential but provides no experimental wet-lab validation."	0.459
38167453	Scientific reports	2024	Integrated whole transcriptome profiling revealed a convoluted circular RNA-based competing endogenous RNAs regulatory network in colorectal cancer.	hsa_circ_0071681				colorectal cancer / CRC	MONDO:0005575	colorectal cancer	unknown	Microarray	"This study identifies hsa_circ_0071681 in an in-silico ceRNA sub-network, proposing it sponges hsa-miR-29a-3p to affect KLF4 and related survival-associated hub genes in CRC. The mechanistic and clinical implications are computationally inferred and require experimental validation."	0.459
38169845	Frontiers in endocrinology	2023	Antioxidants positively regulate obesity dependent circRNAs - sperm quality - functional axis.		circMEMO1	mmu_circ_MEMO1	MEMO1	obesity	MONDO:0011122	obesity disorder	up-regulated	RT-qPCR	circMEMO1 is up-regulated in sperm from HFD-induced obese mice and upon H2O2-induced oxidative stress. Antioxidant supplementation restores its expression alongside normalization of FUS-dependent backsplicing; circMEMO1 is predicted to participate in ceRNA networks linked to oxidative stress and sperm motility.	0.5415
38169845	Frontiers in endocrinology	2023	Antioxidants positively regulate obesity dependent circRNAs - sperm quality - functional axis.		circMAPT	mmu_circ_MAPT	MAPT	obesity	MONDO:0011122	obesity disorder	up-regulated	RT-qPCR	"circMAPT is up-regulated in sperm under HFD-induced obesity and after H2O2-induced oxidative stress, consistent with oxidative stress activating FUS-dependent backsplicing. It is predicted to function through a miRNA/mRNA ceRNA network related to oxidative stress regulation and sperm motility, and its dysregulation is reversed by antioxidant supplementation."	0.5415
38172650	Cellular & molecular biology letters	2024	Circular RNA-circPan3 attenuates cardiac hypertrophy via miR-320-3p/HSP20 axis.		circPan3	rno_circ_Pan3	Pan3	cardiac hypertrophy 	MONDO:0005045	hypertrophic cardiomyopathy	down-regulated	RT-qPCR	"circPan3 is down-regulated in isoproterenol-induced cardiac hypertrophy and functions as an anti-hypertrophic circRNA. It sponges miR-320-3p to relieve repression of HSP20, and its reduced stability in hypertrophy is linked to ALKBH5 downregulation and increased m6A methylation."	0.7941
38172650	Cellular & molecular biology letters	2024	Circular RNA-circPan3 attenuates cardiac hypertrophy via miR-320-3p/HSP20 axis.		circPan3	mmu_circ_Pan3	Pan3	cardiac hypertrophy 	MONDO:0005045	hypertrophic cardiomyopathy	down-regulated	RT-qPCR	"circPan3 is down-regulated in isoproterenol-induced cardiac hypertrophy and functions as an anti-hypertrophic circRNA. It sponges miR-320-3p to relieve repression of HSP20, and its reduced stability in hypertrophy is linked to ALKBH5 downregulation and increased m6A methylation."	0.7941
38176295	"Neoplasia (New York, N.Y.)"	2024	Hsa_circ_0001583 fuels bladder cancer metastasis by promoting staphylococcal nuclease and tudor domain containing 1-mediated MicroRNA decay.	hsa_circ_0001583	hsa_circ_1583 / circ0001583	hsa_circ_HIST1H1C	HIST1H1C	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001583 is up-regulated in bladder cancer tissues and promotes migration/invasion and lung metastasis. Mechanistically, it binds and stabilizes SND1, enhancing SND1-mediated miR-126-3p decay, which relieves repression of ADAM9 and drives a pro-metastatic phenotype."	0.8717
38178201	Journal of orthopaedic surgery and research	2024	m6A-modified circARHGAP12 promotes the aerobic glycolysis of doxorubicin-resistance osteosarcoma by targeting c-Myc.	hsa_circ_0000231	circARHGAP12	hsa_circ_ARHGAP12	ARHGAP12	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"circARHGAP12 is up-regulated in osteosarcoma (including DOX-resistant cells) and promotes doxorubicin resistance, proliferation, and aerobic glycolysis. Mechanistically, its m6A modification enables binding to c-Myc mRNA and increases c-Myc mRNA stability, contributing to chemoresistance-associated metabolic reprogramming."	0.7716
38180297	The Kaohsiung journal of medical sciences	2024	"CircPRDM5 inhibits the proliferation, migration, invasion, and glucose metabolism of gastric cancer cells by reducing GCNT4 expression in a miR-485-3p-dependent manner."	hsa_circ_0005654	circPRDM5 / circ_0005654	hsa_circ_PRDM5	PRDM5	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"circPRDM5 is downregulated in gastric cancer and functions as a tumor suppressor by inhibiting proliferation, migration/invasion, and glycolysis. Mechanistically, it sponges miR-485-3p to upregulate GCNT4, and higher circPRDM5 expression is associated with better overall survival."	0.8593
38184597	Molecular cancer	2024	N6-methyladenosine-modified circPLPP4 sustains cisplatin resistance in ovarian cancer cells via PIK3R1 upregulation.	hsa_circ_0008896	circPLPP4	hsa_circ_PLPP4	PLPP4	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circPLPP4 (hsa_circ_0008896), derived from PLPP4, is upregulated in cisplatin/platinum-resistant ovarian cancer and mainly localizes to the cytoplasm. It promotes cisplatin resistance by sponging miR-136 to upregulate PIK3R1 and activate downstream PI3K/AKT-related signaling, while m6A modification (via METTL3 and IGF2BP1) stabilizes circPLPP4. High circPLPP4 is associated with poor prognosis and reduced OS/RFS in platinum-treated OC patients, and ASO targeting circPLPP4 enhances cisplatin efficacy in xenograft/PDX models."	0.9025
38184608	Molecular cancer	2024	CircPPAP2B controls metastasis of clear cell renal cell carcinoma via HNRNPC-dependent alternative splicing and targeting the miR-182-5p/CYP1B1 axis.	hsa_circ_0002861	circPPAP2B	hsa_circ_PPAR2B	PPAP2B	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circPPAP2B (hsa_circ_0002861), derived from PPAP2B, is upregulated in ccRCC (especially metastatic tumors) and promotes proliferation and metastasis. It binds HNRNPC in an m6A-dependent manner to enhance HNRNPC nuclear translocation and HNRNPC-dependent alternative splicing, and also sponges miR-182-5p to increase CYP1B1 expression, linking to poor prognosis and metastatic discrimination (ROC AUC 0.94)."	0.8968
38192493	"Diabetes, metabolic syndrome and obesity : targets and therapy"	2024	Expression Analysis of circRNAs in Human Adipogenesis.	hsa_circ_0001600	hsa_circFKBP5_002	hsa_circ_FKBP5	FKBP5	obesity	MONDO:0011122	obesity disorder	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001600 is significantly up-regulated during SAT-derived hADSC differentiation into adipocytes. The study predicts it may promote adipogenesis by interacting with miRNAs such as miR-20b-3p/miR-665 (circRNA-miRNA-mRNA network predicted bioinformatically), but does not provide downstream mRNA validation."	0.5135
38192493	"Diabetes, metabolic syndrome and obesity : targets and therapy"	2024	Expression Analysis of circRNAs in Human Adipogenesis.	hsa_circ_0001947				obesity	MONDO:0011122	obesity disorder	up-regulated	Microarray	"has_circ_0001947 is reported as up-regulated during SAT-derived hADSC differentiation into adipocytes, but the full text does not provide explicit RT-qPCR/Sanger validation details for this circRNA ID. The study only presents bioinformatic prediction of its potential target miRNAs (e.g., miR-194-3p, miR-182-5p)."	0.1768
38192493	"Diabetes, metabolic syndrome and obesity : targets and therapy"	2024	Expression Analysis of circRNAs in Human Adipogenesis.	hsa_circ_0001974	hsa_circTKT_008	hsa_circ_TKT	TKT	obesity	MONDO:0011122	obesity disorder	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001974 (host gene TKT) is significantly up-regulated during SAT-derived hADSC differentiation into adipocytes and its back-splice junction was verified. The study proposes a miRNA-related mechanism, suggesting it may induce adipogenesis by inhibiting miR-194 and/or miR-182 (based on predicted circRNA-miRNA-mRNA network)."	0.5135
38193111	Bioengineering & translational medicine	2024	Circular RNA MAP2K2-modified immunosuppressive dendritic cells for preventing alloimmune rejection in organ transplantation.		circMAP2K2	mmu_circ_MAP2K2	MAP2K2 / MEK2	immune rejection	MONDO:1010185	transplant rejection	up-regulated	RT-qPCR	"circMAP2K2 is up-regulated during dendritic cell maturation and supports a mature, inflammatory DC phenotype. Its knockdown in DCs reduces co-stimulatory molecules and inflammatory cytokines, diminishes allogeneic T-cell activation, increases Treg generation, and alleviates alloimmune rejection in a mouse heart transplant model by binding and regulating SENP3 and NF-kappaB signaling."	0.7244
38195468	Journal of orthopaedic surgery and research	2024	"Circ_0006640 transferred by bone marrow-mesenchymal stem cell-exosomes suppresses lipopolysaccharide-induced apoptotic, inflammatory and oxidative injury in spinal cord injury."	mmu_circ_0006640	circ_0006640	mmu_circ_Grm4	Grm4	spinal cord injury / SCI	MONDO:0043797	spinal cord injury	down-regulated	RT-qPCR	"circ_0006640 is down-regulated in SCI mouse spinal cord injury models and in LPS-treated BV2 microglia. Its restoration (including delivery via BMSC-derived exosomes) protects microglia by reducing apoptosis, inflammatory cytokine production, and oxidative stress through a ceRNA mechanism involving miR-382-5p and IGF1."	0.7216
38200573	Human genomics	2024	A novel upregulated hsa_circ_0032746 regulates the oncogenesis of esophageal squamous cell carcinoma by regulating miR-4270/MCM3 axis.	hsa_circ_0032746	circ_0032746 / circ0032746	hsa_circ_C14orf118	c14orf118	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0032746 is up-regulated in ESCC tissues and promotes malignant phenotypes (proliferation, migration, invasion) while reducing apoptosis. Mechanistically, it mainly localizes to the cytoplasm and functions as a ceRNA to sponge miR-4270, thereby increasing MCM3 expression and supporting tumor growth in xenograft models."	0.8071
38203588	International journal of molecular sciences	2023	Plasma Circular-RNA 0005567 as a Potential Marker of Disease Activity in Rheumatoid Arthritis.	hsa_circ_0005567	circ_0005567 / Circular-RNA 0005567	hsa_circ_EPS15	EPS15	rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"circ_0005567 is up-regulated in plasma of rheumatoid arthritis patients and is associated with higher disease activity. In SW982 cells, circ_0005567 knockdown increases miR-194-5p, supporting a potential miRNA-sponge relationship, and is accompanied by increased expression of several proliferation-related mRNAs."	0.6369
38203588	International journal of molecular sciences	2023	Plasma Circular-RNA 0005567 as a Potential Marker of Disease Activity in Rheumatoid Arthritis.	hsa_circ_0000175	circ_0000175			rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	down-regulated	RT-qPCR	"circ_0000175 is down-regulated in plasma of RA patients versus healthy controls in this cohort. However, it was not associated with RA disease activity stratification and did not correlate with clinical variables such as DAS28-ESR, ESR, or CRP."	0.429
38204802	Pharmacogenomics and personalized medicine	2024	circPVT1 Inhibits the Proliferation and Aids in Prediction of the Prognosis of Bladder Cancer.		circPVT1 / Circular RNA PVT1	hsa_circ_PVT1	PVT1	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circPVT1 is up-regulated in BLCA and functions as a tumor suppressor by inhibiting proliferation; its knockdown promotes tumor cell growth in vitro and xenograft growth in vivo. Clinically, high circPVT1 expression predicts better overall survival and may aid diagnosis (high AUC), and it is an independent prognostic factor."	0.7295
38212124	Journal for immunotherapy of cancer	2024	TCCIA: a comprehensive resource for exploring CircRNA in cancer immunotherapy.		circTMTC3	hsa_circ_TMTC3	TMTC3	metastatic melanoma 	MONDO:0005191	metastatic melanoma	up-regulated	RNA-seq	"In metastatic melanoma ICB cohorts, circTMTC3 (notably the isoform TMTC3:+:chr12:88148287:88176319) is higher in non-responders and its high expression predicts worse overall survival. It is linked to immune evasion by increasing PD-L1 via a miR-142-5 p/PD-L1 axis, reducing T cell activity."	0.348
38212124	Journal for immunotherapy of cancer	2024	TCCIA: a comprehensive resource for exploring CircRNA in cancer immunotherapy.		circMGA	hsa_circ_MGA	MGA	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	unknown	RNA-seq	"In a large BLCA immunotherapy cohort analyzed in TCCIA, higher circMGA levels are associated with favorable prognosis, and in early-stage tumors receiving immunotherapy it strongly predicts improved overall survival. Elevated circMGA expression is also associated with a higher CD8 T cell signature, consistent with an immune-attractant role."	0.348
38216551	Nature communications	2024	Mutant KRAS-activated circATXN7 fosters tumor immunoescape by sensitizing tumor-specific T cells to activation-induced cell death.		circATXN7	hsa_circ_ATXN7	ATXN7	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circATXN7 is upregulated in tumor-specific CTLs in KRAS-mutant tumors and promotes tumor immune escape by sensitizing CTLs to activation-induced cell death. It is induced by lactate-driven histone lactylation and directly binds NF-kappaB p65 to block its nuclear translocation, thereby inhibiting NF-kappaB activity. High circATXN7 in CTLs is associated with worse survival and reduced response to immune checkpoint inhibitors, while circATXN7 loss in CD8+ T cells improves antitumor immunity and anti-PD1/ACT efficacy."	0.8921
38216551	Nature communications	2024	Mutant KRAS-activated circATXN7 fosters tumor immunoescape by sensitizing tumor-specific T cells to activation-induced cell death.		circATXN7	mmu_circ_Atxn7	Atxn7	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circATXN7 is upregulated in tumor-specific CTLs in KRAS-mutant tumors and promotes tumor immune escape by sensitizing CTLs to activation-induced cell death. It is induced by lactate-driven histone lactylation and directly binds NF-kappaB p65 to block its nuclear translocation, thereby inhibiting NF-kappaB activity. High circATXN7 in CTLs is associated with worse survival and reduced response to immune checkpoint inhibitors, while circATXN7 loss in CD8+ T cells improves antitumor immunity and anti-PD1/ACT efficacy."	0.8921
38216964	BMC cancer	2024	"Exosomes derived from cancer-associated fibroblasts promote tumorigenesis, metastasis and chemoresistance of colorectal cancer by upregulating circ_0067557 to target Lin28."	hsa_circ_0067557	circ_0067557			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circ_0067557 is enriched/upregulated in CAF-derived exosomes and drives colorectal cancer malignant behaviors and chemoresistance. Mechanistically, circ_0067557 directly binds the RBPs Lin28A and Lin28B, increasing their expression; circ_0067557 silencing reverses CAF-exosome-induced proliferation, EMT/CSC traits, invasion/migration and drug resistance and increases apoptosis, including in xenografts."	0.8124
38216996	Journal of translational medicine	2024	Circular RNA hsa_circ_0050386 suppresses non-small cell lung cancer progression via regulating the SRSF3/FN1 axis.	hsa_circ_0050386		hsa_circ_ANKRD27	ANKRD27	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0050386 is down-regulated in NSCLC tissues and cell lines and acts as a tumor suppressor. It inhibits NSCLC proliferation, cell-cycle progression, migration/invasion, tumor growth and lung metastasis by binding the RBP SRSF3 and reducing FN1 expression (SRSF3/FN1 axis). Decreased hsa_circ_0050386 levels are associated with larger tumor size and more advanced clinical stage."	0.8671
38218855	Journal of orthopaedic surgery and research	2024	"Circ_0000376 regulates miR-577/HK2/LDHA signaling pathway to promote the growth, invasion and glycolysis of osteosarcoma."	hsa_circ_0000376	circ_0000376	hsa_circ_PRH1-PRR4	PRH1-PRR4	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ_0000376 is upregulated in osteosarcoma and promotes proliferation, invasion, glycolysis (Warburg effect) while inhibiting apoptosis. Mechanistically, it sponges miR-577, releasing repression of HK2 and LDHA, thereby driving glycolysis and tumor growth in vitro and in a U2OS xenograft model."	0.7421
38219870	Journal of advanced research	2024	"The circUbqln1, regulated by XBP1s, interplays with 14-3-3zeta to inhibit collagen synthesis and promote osteoarthritis by controlling PRODH activity and proline metabolism."		circUbqln1 / novel_circ_0000710	mmu_circ_Ubqln1	Ubqln1	osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; ISH; RNA-seq	"circUbqln1 is upregulated in OA-related inflammatory conditions and in XBP1-deficient cartilage, promoting OA progression. It binds 14_3_3zeta; phosphorylated 14_3_3zeta facilitates its nuclear translocation, where circUbqln1 enhances Prodh promoter activity to increase PRODH and proline degradation, thereby reducing collagen synthesis and impairing cartilage integrity."	0.8041
38222808	JOR spine	2024	Construction of circ_0071922-miR-15a-5p-mRNA network in intervertebral disc degeneration by RNA-sequencing.	hsa_circ_0071922	circ_0071922			intervertebral disc degeneration / IDD	MONDO:0011385	intervertebral disk degenerative disorder	down-regulated	RT-qPCR; RNA-seq	"circ_0071922 is significantly down-regulated in human IVDD nucleus pulposus tissues and is proposed to regulate an IVDD-related ceRNA network centered on hsa-miR-15a-5p and multiple downstream mRNAs. In a rat needle-puncture IVDD model, circ_0071922 overexpression alleviates degeneration and is associated with increased BCL2 expression in NP tissues."	0.6616
38222808	JOR spine	2024	Construction of circ_0071922-miR-15a-5p-mRNA network in intervertebral disc degeneration by RNA-sequencing.	hsa_circ_0015435	circ_0015435			intervertebral disc degeneration / IDD	MONDO:0011385	intervertebral disk degenerative disorder	up-regulated	RT-qPCR; RNA-seq	"circ_0015435 is the most up-regulated circRNA in IVDD nucleus pulposus tissues based on RNA-seq and RT-PCR/qRT-PCR validation. The study did not identify overlapping downstream miRNAs for circ_0015435 (RNA-seq intersected with CircBank), suggesting a possible miRNA-independent role, but no functional in vitro/in vivo experiments were reported for this circRNA."	0.4032
38225404	NPJ precision oncology	2024	A protein-encoding CCDC7 circular RNA inhibits the progression of prostate cancer by up-regulating FLRT3.			hsa_circ_CCDC7	CCDC7	prostate cancer / PCa	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; RNA-seq	"circCCDC7(15,16,17,18,19) is down-regulated in prostate cancer and lower in higher Gleason score and metastasis. Its higher expression is associated with better patient outcome. Functionally, circCCDC7 suppresses PCa cell viability, migration/invasion and xenograft growth mainly by encoding a secreted peptide (circCCDC7-180aa) that upregulates FLRT3 and mediates tumor-suppressive effects."	0.8814
38226164	iScience	2024	circGlis3 promotes beta-cell dysfunction by binding to heterogeneous nuclear ribonucleoprotein F and encoding Glis3-348aa protein.		circGlis3	hsa_circ_Glis3	Glis3	type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RT-qPCR	"circGlis3 is upregulated in diabetic/lipotoxic beta cells and promotes beta-cell dysfunction in vitro and in vivo. Mechanistically, it (1) binds hnRNPF to block hnRNPF nuclear translocation and reduce Sirt1/SIRT1, and (2) encodes Glis3-348aa, which binds GLIS3 and suppresses GLIS3 transcriptional activity, reducing Ins2/Ngn3/Ccnd2 expression."	0.7616
38226164	iScience	2024	circGlis3 promotes beta-cell dysfunction by binding to heterogeneous nuclear ribonucleoprotein F and encoding Glis3-348aa protein.	mmu_circ_0000943	circGlis3	mmu_circ_Glis3	Glis3	type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RT-qPCR	"circGlis3 is upregulated in diabetic/lipotoxic beta cells and promotes beta-cell dysfunction in vitro and in vivo. Mechanistically, it (1) binds hnRNPF to block hnRNPF nuclear translocation and reduce Sirt1/SIRT1, and (2) encodes Glis3-348aa, which binds GLIS3 and suppresses GLIS3 transcriptional activity, reducing Ins2/Ngn3/Ccnd2 expression."	0.7616
38227372	JCI insight	2024	Circular RNA Cdr1as inhibits proliferation and delays injury-induced regeneration of the intestinal epithelium.		Cdr1as / Cdrlas	hsa_circ_Cdr1	Cdr1	colitis	MONDO:0005292	colitis	up-regulated	RT-qPCR; ISH	"Cdr1as is induced in injured/inflamed intestinal mucosa (mouse colitis/septic stress and human IBD/sepsis) and acts as a negative regulator of intestinal epithelial proliferation and wound repair. Mechanistically, it regulates the Cdr1as/miR-195 axis by affecting miR-195 biogenesis and stabilizing pre-miR-195, thereby impairing epithelial repair and organoid growth; genetic deletion of Cdr1as improves regeneration and protects against colitis."	0.6566
38227372	JCI insight	2024	Circular RNA Cdr1as inhibits proliferation and delays injury-induced regeneration of the intestinal epithelium.		Cdr1as / Cdrlas	mmu_circ_Cdr1	Cdr1	colitis	MONDO:0005292	colitis	up-regulated	RT-qPCR; ISH	"Cdr1as is induced in injured/inflamed intestinal mucosa (mouse colitis/septic stress and human IBD/sepsis) and acts as a negative regulator of intestinal epithelial proliferation and wound repair. Mechanistically, it regulates the Cdr1as/miR-195 axis by affecting miR-195 biogenesis and stabilizing pre-miR-195, thereby impairing epithelial repair and organoid growth; genetic deletion of Cdr1as improves regeneration and protects against colitis."	0.6566
38230215	Journal of Cancer	2024	"n6-methyladenosine-modified circular RNA family with sequence similarity 126, member A affects cholesterol synthesis and malignant progression of prostate cancer cells by targeting microRNA-505-3p to mediate calnexin."	hsa_circ_0001971	circFAM126A	hsa_circ_FAM126A	FAM126A	prostate cancer / PCa / PC	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; RNA-seq	"circFAM126A (hsa_circ_0001971) is up-regulated in prostate cancer and promotes malignant phenotypes and cholesterol synthesis. Mechanistically, m6A/IGF2BP1 increases its RNA stability, and circFAM126A acts as a ceRNA by sponging miR-505-3p to increase CANX expression, enhancing tumor growth and metastasis."	0.8981
38230259	iScience	2024	CircPOFUT1 fosters colorectal cancer metastasis and chemoresistance via decoying miR-653-5p/E2F7/WDR66 axis and stabilizing BMI1.	hsa_circ_0059774	circPOFUT1	hsa_circ_POFUT1	POFUT1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circPOFUT1 (hsa_circ_0059774) is up-regulated in colorectal cancer and promotes proliferation, EMT, metastasis, stemness and 5-Fu chemoresistance. It functions as a ceRNA by sponging miR-653-5p to enhance E2F7 and induce WDR66, and it also recruits IGF2BP1 to stabilize BMI1 mRNA. High circPOFUT1 expression correlates with advanced TNM stage and poor overall survival."	0.8839
38231472	Aging	2024	A circRNA ceRNA network involved in cognitive dysfunction after chronic cerebral hypoperfusion.		circRNA_04107			chronic cerebral hypoperfusion / CCH	MONDO:0006685	brain hypoxia - ischemia	up-regulated	RT-qPCR; RNA-seq	"circRNA_04107 was identified as significantly up-regulated in rat hippocampus after chronic cerebral hypoperfusion and was validated by RT-qPCR. It was included as a node in a predicted circRNA-miRNA-mRNA ceRNA network enriched for immune/inflammation-related processes, but its specific miRNA/mRNA targets and functional effects were not experimentally validated."	0.4997
38231472	Aging	2024	A circRNA ceRNA network involved in cognitive dysfunction after chronic cerebral hypoperfusion.		circRNA_08563			chronic cerebral hypoperfusion / CCH	MONDO:0006685	brain hypoxia - ischemia	up-regulated	RT-qPCR	"circRNA_08563 was RT-qPCR-validated as up-regulated in rat hippocampus after chronic cerebral hypoperfusion. It was part of the study¡¯s broader predicted ceRNA framework linked to immune/inflammation-related changes, but no circRNA_08563-specific targets or functional assays were reported."	0.31
38231472	Aging	2024	A circRNA ceRNA network involved in cognitive dysfunction after chronic cerebral hypoperfusion.		circRNA_01617			chronic cerebral hypoperfusion / CCH	MONDO:0006685	brain hypoxia - ischemia	up-regulated	RT-qPCR	"circRNA_01617 was RT-qPCR-validated as up-regulated in rat hippocampus after chronic cerebral hypoperfusion. It was implicated at the network level in predicted ceRNA regulation related to immune/inflammation-associated changes, but no circRNA_01617-specific mechanism was experimentally tested."	0.31
38231472	Aging	2024	A circRNA ceRNA network involved in cognitive dysfunction after chronic cerebral hypoperfusion.		circRNA_08831			chronic cerebral hypoperfusion / CCH	MONDO:0006685	brain hypoxia - ischemia	down-regulated	RT-qPCR	"circRNA_08831 was RT-qPCR-validated as down-regulated in rat hippocampus after chronic cerebral hypoperfusion. It was only analyzed in the context of the study¡¯s predicted ceRNA/inflammation-related transcriptomic changes, without circRNA_08831-specific mechanistic validation."	0.31
38231472	Aging	2024	A circRNA ceRNA network involved in cognitive dysfunction after chronic cerebral hypoperfusion.		circRNA_08834			chronic cerebral hypoperfusion / CCH	MONDO:0006685	brain hypoxia - ischemia	down-regulated	RT-qPCR	"circRNA_08834 was RT-qPCR-validated as down-regulated in rat hippocampus after chronic cerebral hypoperfusion. The paper did not provide circRNA_08834-specific functional experiments, only network-level predicted ceRNA/inflammation associations."	0.31
38231472	Aging	2024	A circRNA ceRNA network involved in cognitive dysfunction after chronic cerebral hypoperfusion.		circRNA_07989			chronic cerebral hypoperfusion / CCH	MONDO:0006685	brain hypoxia - ischemia	down-regulated	RT-qPCR	circRNA_07989 was RT-qPCR-validated as down-regulated in rat hippocampus after chronic cerebral hypoperfusion. The study did not investigate its individual downstream miRNA/mRNA interactions or biological functions beyond inclusion in predicted ceRNA/inflammation-related analyses.	0.31
38233907	BMC biology	2024	The accumulation of modular serine protease mediated by a novel circRNA sponging miRNA increases Aedes aegypti immunity to fungus.		novel-circ-930			Beauveria bassiana infection / fungal infection	MONDO:0002041	fungal infectious disease	up-regulated	RT-qPCR	"In Aedes aegypti during Beauveria bassiana infection, novel-circ-930 is upregulated and promotes antifungal immunity by sponging miRNA-novel-53, thereby derepressing ModSP mRNA and increasing ModSP expression. It localizes in the cytoplasm and directly binds miRNA-novel-53 as supported by luciferase assays and FISH."	0.7126
38243118	Communications biology	2024	Circular RNA cVIM promotes hepatic stellate cell activation in liver fibrosis via miR-122-5p/miR-9-5p-mediated TGF-beta signaling cascade.		cVIM / mmu_circ_32994	mmu_circ_Vim	Vim	liver fibrosis	MONDO:0005155	cirrhosis of liver	up-regulated	RT-qPCR; Microarray	"In mouse liver fibrosis models, cVIM (Vim-derived circRNA) is upregulated and mainly cytoplasmic. It promotes hepatic stellate cell activation and fibrogenesis by sponging miR-122-5p and miR-9-5p, thereby increasing TGFBR1/TGFBR2 and activating TGF-beta/Smad signaling; its transcription is activated by Sp1 and may form a positive feedback loop. cVIM knockdown suppresses fibrosis progression in vivo."	0.8875
38243118	Communications biology	2024	Circular RNA cVIM promotes hepatic stellate cell activation in liver fibrosis via miR-122-5p/miR-9-5p-mediated TGF-beta signaling cascade.	hsa_circ_0017884	hsa-cVIM	hsa_circ_VIM	VIM	liver fibrosis	MONDO:0005155	cirrhosis of liver	up-regulated	RT-qPCR	"In human CHB/CHC-related liver fibrosis, hsa_circ_0017884 (hsa-cVIM) is upregulated in liver tissue and serum. Serum hsa-cVIM shows diagnostic utility for liver fibrosis and correlates positively with fibrosis stage."	0.4758
38243224	Journal of nanobiotechnology	2024	CircNUP50 is a novel therapeutic target that promotes cisplatin resistance in ovarian cancer by modulating p53 ubiquitination.	hsa_circ_0002077	circNUP50	hsa_circ_NUP50	NUP50	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; RNA-seq	"circNUP50 (hsa_circ_0002077), derived from NUP50, is up-regulated in platinum/cisplatin-resistant ovarian cancer tissues and resistant cell lines. It promotes platinum resistance by enhancing proliferation, driving G0/G1 cell-cycle progression, and suppressing apoptosis. Mechanistically, it scaffolds p53 with UBE2T to accelerate p53 ubiquitination and also sponges miR-197-3p to upregulate G3BP1, further promoting p53 ubiquitination."	0.8125
38244593	Aging	2024	Circ0060467 sponges miR-6805 to promote hepatocellular carcinoma progression through regulating AIFM2 and GPX4 expression.	hsa_circ_0060467	circ0060467 / circ-0060467	hsa_circ_MYBL2	MYBL2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circ0060467 is upregulated in HCC tissues and cell lines and promotes tumor growth. Mechanistically, it acts as a ceRNA/miRNA sponge to regulate AIFM2 and GPX4, thereby inhibiting ferroptosis and facilitating HCC progression. It is proposed as a potential diagnostic marker and therapeutic target for HCC."	0.8432
38245550	NPJ Parkinson's disease	2024	Early-stage idiopathic Parkinson's disease is associated with reduced circular RNA expression.			hsa_circ_ESYT2	ESYT2	Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	down-regulated	RNA-seq	A circRNA derived from the host gene ESYT2 shows decreased expression in early-stage idiopathic Parkinson¡¯s disease whole blood (significant in PPMI with a similar decreasing trend in ICICLE-PD). No specific downstream miRNA/target/mechanism for this circRNA is experimentally defined in the paper.	0.1768
38245550	NPJ Parkinson's disease	2024	Early-stage idiopathic Parkinson's disease is associated with reduced circular RNA expression.			hsa_circ_BMS1P1	BMS1P1	Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	down-regulated	RNA-seq	A circRNA derived from BMS1P1 is reported as decreased in early-stage idiopathic Parkinson¡¯s disease whole blood (significant in PPMI; similar decreasing trend in ICICLE-PD). The study does not define a specific molecular interaction network for this circRNA.	0.1768
38245550	NPJ Parkinson's disease	2024	Early-stage idiopathic Parkinson's disease is associated with reduced circular RNA expression.			hsa_circ_CCDC9	CCDC9	Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	down-regulated	RNA-seq	"A circRNA derived from CCDC9 is identified as decreased in early-stage idiopathic Parkinson¡¯s disease whole blood (significant in PPMI; similar decreasing trend in ICICLE-PD). The paper provides no direct mechanistic validation (e.g., miRNA sponge assays) for this circRNA."	0.1768
38245591	Discover oncology	2024	CircUCK2 promotes hepatocellular carcinoma development by upregulating UCK2 in a mir-149-5p-dependent manner.	hsa_circ_0006758	CircUCK2	hsa_circ_UCK2	UCK2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circUCK2 is up-regulated in HCC tissues, cells, and patient serum. It promotes malignant phenotypes (proliferation, migration, invasion/EMT and tumor growth) and suppresses apoptosis by sponging miR-149-5p to upregulate UCK2."	0.8654
38245787	European journal of medical research	2024	"circNINL facilitates aerobic glycolysis, proliferation, invasion, and migration in lung cancer by sponging miR-3918 to mediate FGFR1 expression."		circNINL / circular RNA NINL	hsa_circ_NINL	NINL	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circNINL is up-regulated in lung cancer tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion) and aerobic glycolysis while suppressing apoptosis. Mechanistically, circNINL functions as a ceRNA that sponges miR-3918 to de-repress FGFR1, and circNINL knockdown suppresses tumor growth in a nude mouse xenograft model. High circNINL expression is associated with poor overall survival and shows diagnostic potential in LC patients."	0.8769
38249464	Frontiers in microbiology	2023	Circular RNA network plays a potential antiviral role in the early stage of JEV infection in mouse brain.		circStrbp	mmu_circ_Strbp	Strbp	Japanese encephalitis / JEV infection	MONDO:0019209	Japanese encephalitis	down-regulated	RT-qPCR; RNA-seq	"In JEV-infected mouse brain and BV2 microglia, circStrbp is down-regulated and forms a ceRNA axis with miR-709 and CX3CR1. Perturbing circStrbp (siRNA) alters miR-709/CX3CR1 expression and reduces JEV mRNA levels, suggesting this axis influences viral replication during infection."	0.6427
38249464	Frontiers in microbiology	2023	Circular RNA network plays a potential antiviral role in the early stage of JEV infection in mouse brain.		Tulp4	mmu_circ_Tulp4	Tulp4	Japanese encephalitis / JEV infection	MONDO:0019209	Japanese encephalitis	down-regulated	RT-qPCR; RNA-seq	Tulp4 is a down-regulated circRNA in JEV-infected mouse brain and was selected for RT-qPCR validation as part of the ceRNA network profiling. The paper does not further define a specific downstream miRNA/mRNA axis or functional role for Tulp4 beyond differential expression.	0.4844
38249464	Frontiers in microbiology	2023	Circular RNA network plays a potential antiviral role in the early stage of JEV infection in mouse brain.		zfyve9	mmu_circ_Zfyve9	Zfyve9	Japanese encephalitis / JEV infection	MONDO:0019209	Japanese encephalitis	down-regulated	RT-qPCR; RNA-seq	The circRNA derived from Zfyve9 is down-regulated in JEV-infected mouse brain and was validated by RT-qPCR as part of the ceRNA profiling. The study does not further establish a specific functional/mechanistic axis for this circRNA beyond differential expression.	0.4844
38255868	International journal of molecular sciences	2024	Circ-MBOAT2 Regulates Angiogenesis via the miR-495/NOTCH1 Axis and Associates with Myocardial Perfusion in Patients with Coronary Chronic Total Occlusion.		circ-MBOAT2 / circ-membrane-bound O-acyltransferase domain containing 2	hsa_circ_MBOAT2	MBOAT2	coronary chronic total occlusion / CTO	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR; RNA-seq	"circ-MBOAT2 is up-regulated in plasma from patients with coronary chronic total occlusion and promotes angiogenesis in endothelial cells. Mechanistically, it sponges miR-495 to increase NOTCH1 expression, enhancing tube formation and migration, and its higher level associates with myocardial perfusion improvement after CTO revascularization."	0.6829
38263208	Scientific reports	2024	Circular RNA DNAH14 molecular mechanism in an experimental model of hepatocellular carcinoma treated with Cobalt chloride to mimic the hypoxia-like response of transcatheter arterial chemoembolization.		circular RNA DNAH14 / circDNAH14	hsa_circ_DNAH14	DNAH14	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"In a cobalt chloride-induced hypoxia model mimicking TACE, circDNAH14 is down-regulated in hypoxic HCC cells and functionally counteracts hypoxia-induced suppression of malignant phenotypes. It sponges miR-508-3p to maintain PTMA expression (circDNAH14/miR-508-3p/PTMA), thereby promoting proliferation/migration/invasion/EMT and reducing apoptosis; circDNAH14 knockdown enhances hypoxia-induced tumor growth inhibition in xenografts."	0.6831
38263330	EMBO reports	2024	Interferon induced circRNAs escape herpesvirus host shutoff and suppress lytic infection.	hsa_circ_0001400	circRELL1 / circ_0001400	hsa_circ_RELL1	RELL1	Herpes simplex virus-1 / HSV-1 lytic infection	MONDO:0004609	herpes simplex infectious disease	up-regulated	RT-qPCR; RNA-seq	"circRELL1 (hsa_circ_0001400) is induced during herpesvirus infection and by interferon stimulation. In HSV-1 lytic infection, circRELL1 restricts production of infectious progeny, supported by siRNA knockdown and lentiviral overexpression experiments; it may act in part via interaction with TTI1 mRNA, though the mechanism is not fully defined."	0.4062
38263330	EMBO reports	2024	Interferon induced circRNAs escape herpesvirus host shutoff and suppress lytic infection.	hsa_circ_0000479	circEPSTI1	hsa_circ_EPSTI1	EPSTI1	Herpesvirus infection	MONDO:0005550	infectious disease	up-regulated	RNA-seq	"circEPSTI1 (hsa_circ_0000479), derived from EPSTI1, is consistently induced by interferon treatment across tested cell models and is also responsive in PBMCs after IFN-beta. The study does not define a specific antiviral mechanism or downstream targets for circEPSTI1."	0.1155
38263330	EMBO reports	2024	Interferon induced circRNAs escape herpesvirus host shutoff and suppress lytic infection.	mmu_circ_0001396	circMed13l	mmu_circ_Med13l	Med13l	Herpes simplex virus-1 / HSV-1 lytic infection	MONDO:0004609	herpes simplex infectious disease	up-regulated	RNA-seq	circMed13l (mmu_circ_0001396) is consistently upregulated across murine HSV-1 and MHV68 infection models based on RNA-seq profiling. The study does not provide functional or mechanistic validation for circMed13l.	0.2586
38267865	Cellular & molecular biology letters	2024	Regulation of tumor metastasis and CD8+ T cells infiltration by circRNF216/miR-576-5p/ZC3H12C axis in colorectal cancer.	hsa_circ_0079284	circRNF216 / circ-RNF216	hsa_circ_RNF216	RNF216	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"circRNF216 (RNF216-derived exonic circRNA) is down-regulated in colorectal cancer and acts as a tumor suppressor. It sponges miR-576-5p to de-repress ZC3H12C, leading to reduced N-cadherin and inhibited migration/invasion/metastasis, and it also enhances CD8+ T-cell infiltration/proliferation via ZC3H12C, supporting potential diagnostic/therapeutic value."	0.8684
38268309	Thoracic cancer	2024	Triptolide inhibits esophageal squamous cell carcinoma progression by regulating the circNOX4/miR-153-3p/SATB1 signaling pathway.	hsa_circ_0023990	circNOX4 / Circ_0023990	hsa_circ_NOX4	NOX4	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circNOX4 is up-regulated in ESCC and promotes malignant phenotypes (proliferation, cell cycle progression, migration/invasion and EMT) while inhibiting apoptosis. Mechanistically, circNOX4 sponges miR-153-3p to upregulate SATB1; triptolide suppresses ESCC partly by downregulating circNOX4 and inhibiting the circNOX4/miR-153-3p/SATB1 axis."	0.8443
38269201	Iranian journal of biotechnology	2023	Research on Circular RNA Expression Profiles in the Photoaging Mouse Model.		circ_001194 / mmu_circRNA_001194	mmu_circ_Ubp1	Ubp1	photoaging	MONDO:0005093	skin disorder	down-regulated	RT-qPCR; Microarray	"In the UVA+UVB-induced mouse photoaging model, circ_001194 (mmu_circRNA_001194, host gene Ubp1) is down-regulated in skin tissue. Its differential expression was identified by microarray and confirmed by RT-qPCR."	0.4625
38269201	Iranian journal of biotechnology	2023	Research on Circular RNA Expression Profiles in the Photoaging Mouse Model.		circ_018777 / mmu_circRNA_018777	mmu_circ_Col3a1	Col3a1	photoaging	MONDO:0005093	skin disorder	down-regulated	RT-qPCR; Microarray	"In the UVA+UVB-induced mouse photoaging model, circ_018777 (mmu_circRNA_018777, host gene Col3a1) is down-regulated in skin tissue. Its differential expression was identified by microarray and confirmed by RT-qPCR."	0.4625
38270303	"Immunity, inflammation and disease"	2024	Circ_0087199 depletion attenuates lipopolysaccharides-induced human periodontal ligament cell injury through the miR-527/TLR4 axis.	hsa_circ_0087199	circ_0087199	hsa_circ_GDA	GDA	periodontitis	MONDO:0005076	periodontitis	up-regulated	RT-qPCR	"circ_0087199 is up-regulated in periodontal ligament tissues from periodontitis patients and in LPS-stimulated PDLCs. Functionally, circ_0087199 promotes LPS-induced PDLC injury (reduced viability/proliferation and increased apoptosis, inflammation, and oxidative stress) by acting as a ceRNA that sponges miR-527 to increase TLR4."	0.7416
38271077	Aging	2024	Consistency of mouse models with human intracerebral hemorrhage: core targets and non-coding RNA regulatory axis.		mmu-circRNA-000895 / circRNA-000895			intracerebral hemorrhage / ICH	MONDO:0013792	intracerebral hemorrhage	up-regulated	Microarray	"mmu-circRNA-000895 is up-regulated in mouse brain 3 days after ICH and is predicted to act as a ceRNA by binding multiple miRNAs. The highlighted translationally relevant axis is circRNA-000895/miR-335-5p regulating PPBP, CSF1 and TLR4 in the context of ICH-associated inflammatory/chemokine responses."	0.4375
38273320	Cancer cell international	2024	CircRAD23B promotes proliferation and carboplatin resistance in ovarian cancer cell lines and organoids.	hsa_circ_0087855	circRAD23B	hsa_circ_RAD23B	RAD23B	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"CircRAD23B (hsa_circ_0087855), derived from RAD23B, is upregulated in ovarian cancer, particularly in carboplatin-resistant tissues, and is mainly localized in the cytoplasm. It promotes proliferation and carboplatin resistance by sponging miR-1287-5p to relieve repression of YBX1, thereby increasing YBX1 expression and enhancing tumor growth and chemoresistance in cells, patient-derived organoids, and xenograft models."	0.8751
38275418	Biomedicines	2024	"Hsa_circ_0092856 Promoted the Proliferation, Migration, and Invasion of NSCLC Cells by Up-Regulating the Expression of eIF3a."	hsa_circ_0092856	hsa_circ_0092856	hsa_circ_eIF3a	eIF3a	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0092856 is up-regulated in NSCLC cell lines and promotes proliferation, migration, and invasion. It localizes mainly to the cytoplasm and appears not to act as an AGO2-associated miRNA sponge; instead, it enhances NSCLC progression by up-regulating its host/parental gene eIF3a (with associated changes such as increased p-Akt and BCL2 and reduced BAX and E-cadherin upon overexpression)."	0.6649
38277288	Clinical hemorheology and microcirculation	2024	CircLZIC regulates ox-LDL-induced HUVEC cell proliferation and apoptosis via Micro-330-5p/NOTCH2 axis in atherosclerosis.		CircLZIC	hsa_circ_LZIC	LZIC	atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR; RNA-seq	"CircLZIC is up-regulated in atherosclerosis serum and in ox-LDL-treated HUVECs, and it promotes HUVEC proliferation/cell activity while inhibiting apoptosis. Mechanistically, circLZIC directly binds Micro-330-5p and modulates NOTCH2, forming a circLZIC/Micro-330-5p/NOTCH2 regulatory axis in AS."	0.7858
38280941	Oncogene	2024	Novel exosomal circEGFR facilitates triple negative breast cancer autophagy via promoting TFEB nuclear trafficking and modulating miR-224-5p/ATG13/ULK1 feedback loop.	hsa_circ_0080222	circEGFR	hsa_circ_EGFR	EGFR	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; RNA-seq	"circEGFR (hsa_circ_0080222), an EGFR-derived cytoplasmic circRNA enriched in exosomes, is upregulated in TNBC and plasma exosomes from breast cancer patients. It promotes TNBC autophagy and malignant behaviors by binding ANXA2 to enable TFEB nuclear translocation and by acting as a ceRNA for miR-224-5p to upregulate ATG13/ULK1."	0.8861
38281919	BMC biology	2024	A computational model of circRNA-associated diseases based on a graph neural network: prediction and case studies for follow-up experimental validation.		hsa_circRNA_104135			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"CircDA predicted hsa_circRNA_104135 to be associated with HCC, and RT-qPCR in paired human HCC vs paracancerous tissues showed it is significantly up-regulated in HCC."	0.2995
38281919	BMC biology	2024	A computational model of circRNA-associated diseases based on a graph neural network: prediction and case studies for follow-up experimental validation.		hsa_circRNA_400031			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"CircDA predicted hsa_circRNA_400031 to be associated with HCC, and RT-qPCR in paired human HCC vs paracancerous tissues showed it is significantly up-regulated in HCC."	0.2995
38281919	BMC biology	2024	A computational model of circRNA-associated diseases based on a graph neural network: prediction and case studies for follow-up experimental validation.		hsa_circRNA_103809			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"CircDA predicted hsa_circRNA_103809 to be associated with HCC, and RT-qPCR in paired human HCC vs paracancerous tissues showed it is significantly up-regulated in HCC."	0.2995
38281919	BMC biology	2024	A computational model of circRNA-associated diseases based on a graph neural network: prediction and case studies for follow-up experimental validation.		hsa_circRNA_100571			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"CircDA predicted hsa_circRNA_100571 to be associated with HCC, and RT-qPCR in paired human HCC vs paracancerous tissues showed it is significantly up-regulated in HCC."	0.2995
38281919	BMC biology	2024	A computational model of circRNA-associated diseases based on a graph neural network: prediction and case studies for follow-up experimental validation.		hsa_circRNA_102032			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"CircDA predicted hsa_circRNA_102032 to be associated with HCC, and RT-qPCR in paired human HCC vs paracancerous tissues showed it is significantly up-regulated in HCC."	0.2995
38282862	PeerJ	2024	A peptide encoded by the circular form of the SHPRH gene induces apoptosis in neuroblastoma cells.		circSHPRH / circ-SHPRH	hsa_circ_SHPRH	SHPRH	neuroblastoma / NB	MONDO:0005072	neuroblastoma	down-regulated	RT-qPCR; Microarray	"circ-SHPRH is down-regulated in neuroblastoma samples/cell lines. Forced circ-SHPRH overexpression suppresses neuroblastoma malignant phenotypes and promotes apoptosis, accompanied by decreased Bcl-2 and increased Caspase-3, with a related SHPRH-146aa/RUNX1/NFKBIA regulatory circuit described in the study."	0.5067
38287200	Cancer science	2024	Circular RNA circWNK1 inhibits the progression of gastric cancer via regulating the miR-21-3p/SMAD7 axis.	hsa_circ_0003251	circWNK1	hsa_circ_WNK1	WNK1	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"circWNK1 (hsa_circ_0003251), derived from WNK1, is down-regulated in gastric cancer tissues/cell lines and acts as a tumor suppressor. It sponges miR-21-3p to restore SMAD7 expression, thereby inhibiting TGF-beta/SMAD signaling, leading to reduced proliferation, migration, invasion, EMT, tumor growth and metastasis. Low circWNK1 expression is linked to worse overall survival and has diagnostic potential (AUC 0.714)."	0.8889
38287405	Respiratory research	2024	Circ-phkb promotes cell apoptosis and inflammation in LPS-induced alveolar macrophages via the TLR4/MyD88/NF-kB/CCL2 axis.		circ-Phkb	rno_circ_PHKB	Phkb	acute lung injury / ALI	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR; RNA-seq	"In LPS-induced ALI models, circ-Phkb is up-regulated in rat lung tissue and alveolar macrophages/NR8383 cells. Functionally, it decreases macrophage viability/proliferation and increases apoptosis and inflammatory cytokine release. Mechanistically, it promotes TLR4/MyD88/NF-kB activation and upregulates CCL2."	0.6586
38291092	Scientific reports	2024	CircXRN2 accelerates colorectal cancer progression through regulating miR-149-5p/MACC1 axis and EMT.	hsa_circ_0114838	circXRN2 / circ-XRN2	hsa_circ_XRN2	XRN2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"circXRN2 is up-regulated in colorectal cancer tissues/cells and promotes CRC cell proliferation, migration, invasion and in vivo metastasis while inhibiting apoptosis. Mechanistically, it sponges miR-149-5p to upregulate ENC1 and induce EMT-related protein changes, forming a circXRN2/miR-149-5p/ENC1/EMT axis. High circXRN2 expression is associated with poorer prognosis in CRC patients."	0.8871
38297223	The journal of physiological sciences : JPS	2024	Circ_0114428 knockdown inhibits ROCK2 expression to assuage lipopolysaccharide-induced human pulmonary alveolar epithelial cell injury through miR-574-5p.	hsa_circ_0114428	circular RNA_0114428 / circ_0114428	hsa_circ_ZNF644	ZNF644	sepsis-induced acute lung injury	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR	"circ_0114428 is up-regulated in serum/blood from sepsis-induced ALI patients and in LPS-treated HPAEpiCs, and its knockdown alleviates LPS-induced epithelial injury (improves viability/proliferation, reduces apoptosis, inflammation and oxidative stress). Mechanistically, circ_0114428 functions as a ceRNA by sponging miR-574-5p to increase ROCK2 expression (circ_0114428/miR-574-5p/ROCK2 axis), and shows diagnostic potential for ALI."	0.8568
38297362	Molecular cancer	2024	Role of a novel circRNA-CGNL1 in regulating pancreatic cancer progression via NUDT4-HDAC4-RUNX2-GAMT-mediated apoptosis.	hsa_circ_0035435	circ_0035435 / circCGNL1	hsa_circ_CGNL1	CGNL1	pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	down-regulated	RT-qPCR	"circCGNL1 is down-regulated in pancreatic cancer and functions as a tumor suppressor by inhibiting proliferation and promoting apoptosis. Mechanistically, circCGNL1 binds NUDT4 to enhance HDAC4 dephosphorylation and nuclear translocation, leading to RUNX2 deacetylation/degradation, derepression of GAMT, and activation of AMPK_AKT_Bad/caspase-3-associated apoptosis. Low circCGNL1 expression is associated with worse overall survival in PC patients."	0.8862
38300888	Annals of medicine	2024	Elevated expression of hsa_circ_0000479 in neutrophils correlates with features of systemic lupus erythematosus.	hsa_circ_0000479	hsa_circRNA_000479	hsa_circ_EPSTI1	EPSTI1	systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	up-regulated	RT-qPCR	"hsa_circ_0000479 (from host gene EPSTI1) is up-regulated in neutrophils from SLE patients versus healthy controls. Its higher neutrophil expression correlates with key laboratory parameters (e.g., lower NEUT and C3; higher anti-dsDNA and anti-nucleosome antibodies) and with Raynaud¡¯s phenomenon, alopecia, and leucopenia, indicating potential involvement in SLE immune dysregulation and possible clinical value."	0.5129
38304778	Heliyon	2024	Circular RNA circTMEM59 inhibits progression of pancreatic ductal adenocarcinoma by targeting miR-147b/SOCS1: An in vitro study.	hsa_circ_0012634	circTMEM59	hsa_circ_TMEM59	TMEM59	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	down-regulated	RT-qPCR; Microarray	"circTMEM59 is down-regulated in PDAC tissues/cell lines and functions as a tumor suppressor. It sponges miR-147b to relieve repression of SOCS1, thereby inhibiting PDAC cell proliferation, invasion and EMT, and low circTMEM59 associates with worse survival."	0.814
38305450	Journal of the Chinese Medical Association : JCMA	2024	Dysregulation of the circRNA_0087207/miR-548c-3p/PLSR1-TGFB2 axis in Leber hereditary optic neuropathy in vitro.	hsa_circ_0087207	circRNA_0087207			Leber hereditary optic neuropathy / LHON	MONDO:0010788	Leber hereditary optic neuropathy	up-regulated	RT-qPCR; RNA-seq	"In LHON patient iPSC-derived retinal ganglion cells, circRNA_0087207 is up-regulated and functions as a sponge for miR-548c-3p. By suppressing miR-548c-3p activity, it increases downstream targets including PLSCR1 and TGFB2 and is implicated in promoting apoptosis in diseased RGCs, with proposed biomarker potential."	0.4997
38309290	Aging	2024	circ_0039787 promotes cervical cancer cell tumorigenesis by regulation of the miR-877-5p-KRAS axis.	hsa_circ_0039787	circ_0039787	hsa_circ_C16orf70	C16orf70	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"circ_0039787 is up-regulated in cervical cancer tissues/serum/cell lines and acts as an oncogenic circRNA. It mainly localizes to the cytoplasm and promotes CC cell proliferation, migration, invasion and xenograft tumor growth by sponging miR-877-5p, thereby increasing KRAS expression (circ_0039787/miR-877-5p/KRAS ceRNA axis). It also shows diagnostic potential by ROC analysis in patient serum."	0.8427
38311675	Cell biology and toxicology	2024	Circular RNA circFCHO2(hsa_circ_0002490) promotes the proliferation of melanoma by directly binding to DND1.	hsa_circ_0002490	circFCHO2	hsa_circ_FCHO2	FCHO2	melanoma	MONDO:0005105	melanoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circFCHO2 (hsa_circ_0002490), derived from the FCHO2 gene, is up-regulated in melanoma and mainly localized in the cytoplasm. It promotes melanoma proliferation, migration, invasion and xenograft growth by directly binding the RBP DND1, thereby relieving DND1-mediated suppression of PI3K/AKT signaling (increasing p-AKT). High circFCHO2 expression is associated with worse OS/DFS and serves as an independent prognostic risk factor."	0.8792
38313582	Experimental and therapeutic medicine	2024	Role of the circular RNA regulatory network in the pathogenesis of biliary atresia.	hsa_circ_0006137				biliary atresia / BA	MONDO:0008867	biliary atresia	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0006137 is up-regulated in BA liver tissue versus CC controls (RNA-seq and RT-qPCR). It was incorporated into a predicted ceRNA network and linked to miR-26a-5p and miR-145-5p, with downstream enrichment pointing to TGF-beta and EGFR-related pathways; it also showed diagnostic potential (ROC AUC >0.8)."	0.5047
38313582	Experimental and therapeutic medicine	2024	Role of the circular RNA regulatory network in the pathogenesis of biliary atresia.	hsa_circ_0079422				biliary atresia / BA	MONDO:0008867	biliary atresia	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0079422 is up-regulated in BA liver tissue versus CC controls (RT-qPCR). It was included in a predicted circRNA-miRNA network with miR-593-3p and contributed to a network whose downstream targets were enriched in TGF-beta and EGFR-related pathways; it showed diagnostic utility (ROC AUC >0.8).	0.5047
38313582	Experimental and therapeutic medicine	2024	Role of the circular RNA regulatory network in the pathogenesis of biliary atresia.	hsa_circ_0007375				biliary atresia / BA	MONDO:0008867	biliary atresia	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0007375 is up-regulated in BA liver tissue versus CC controls (RT-qPCR). It was used to build a predicted circRNA-miRNA network and was linked to miR-1206 and miR-1208; the overall network¡¯s downstream targets were enriched in TGF-beta signaling and EGFR tyrosine kinase inhibitor resistance pathways, and this circRNA had diagnostic potential (ROC AUC >0.8)."	0.5047
38313582	Experimental and therapeutic medicine	2024	Role of the circular RNA regulatory network in the pathogenesis of biliary atresia.	hsa_circ_0081171				biliary atresia / BA	MONDO:0008867	biliary atresia	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0081171 is down-regulated in BA liver tissue versus CC controls (RT-qPCR). It was included in the predicted circRNA-miRNA network with miR-18a-5p, and the network¡¯s downstream targets were enriched in TGF-beta signaling and EGFR tyrosine kinase inhibitor resistance pathways; it showed diagnostic potential (ROC AUC >0.8)."	0.5047
38313582	Experimental and therapeutic medicine	2024	Role of the circular RNA regulatory network in the pathogenesis of biliary atresia.	hsa_circ_0084665				biliary atresia / BA	MONDO:0008867	biliary atresia	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0084665 is down-regulated in BA liver tissue versus CC controls (RT-qPCR). It was included in the predicted circRNA-miRNA network with miR-22-5p, and the network¡¯s downstream targets were enriched in TGF-beta signaling and EGFR tyrosine kinase inhibitor resistance pathways; it showed diagnostic potential (ROC AUC >0.8)."	0.5047
38321126	Scientific reports	2024	IGF2BP2-m6A-circMMP9 axis recruits ETS1 to promote TRIM59 transcription in laryngeal squamous cell carcinoma.	hsa_circ_0060571	circMMP9	hsa_circ_MMP9	MMP9	laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circMMP9 (hsa_circ_0060571), derived from MMP9 exons 9_13, is up-regulated in LSCC and promotes proliferation and metastatic behaviors. Mechanistically, it is m6A-modified and stabilized by IGF2BP2, recruits ETS1 to enhance TRIM59 transcription, and drives LSCC progression via TRIM59-mediated PI3K/AKT activation; high circMMP9 indicates poor survival."	0.8754
38323094	"Research (Washington, D.C.)"	2024	A Novel Circular RNA circITGa9 Predominantly Generated in Human Heart Disease Induces Cardiac Remodeling and Fibrosis.		circITGa9	hsa_circ_ITGA9	ITGA9	cardiac hypertrophy	MONDO:0005045	hypertrophic cardiomyopathy	up-regulated	RT-qPCR; RNA-seq	"circITGa9 (hg38_circ_0030600), derived from ITGA9, is up-regulated in hypertrophy-associated heart disease and promotes cardiac remodeling/fibrosis. Mechanistically it binds TPM3, disrupts TPM3_actin interaction, increases actin polymerization, and enhances collagen deposition; silencing or blocking the circITGa9_TPM3 interaction improves cardiac function and reduces fibrosis."	0.8468
38324181	Molecular neurobiology	2024	Exosomal circZNF800 Derived from Glioma Stem-like Cells Regulates Glioblastoma Tumorigenicity via the PIEZO1/Akt Axis.	hsa_circ_0082096	circZNF800	hsa_circ_ZNF800	ZNF800	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; RNA-seq	"circZNF800 (hsa_circ_0082096), derived from ZNF800 and enriched in GSLC exosomes, is up-regulated in GBM and mainly localized in the cytoplasm. It promotes GBM proliferation and migration and inhibits apoptosis by sponging miR-139-5p to increase PIEZO1 and activate downstream FAK/Akt signaling, and high circZNF800 predicts poorer survival."	0.8699
38328044	bioRxiv : the preprint server for biology	2024	m6A-dependent circular RNA formation mediates tau-induced neurotoxicity.		circMbl	dme_circ_mbl	mbl	tauopathy / Alzheimer¡¯s disease	MONDO:0005574	tauopathy	up-regulated	ISH; RNA-seq	"In a Drosophila tauopathy model, circMbl is elevated and its depletion suppresses tau-induced neurotoxicity, including reduced neuronal apoptosis and improved locomotor deficits. Mechanistically, tau increases m6A RNA methylation, which promotes circMbl formation; circMbl and m6A accumulate in/near lamin-lined nuclear blebs."	0.4852
38328044	bioRxiv : the preprint server for biology	2024	m6A-dependent circular RNA formation mediates tau-induced neurotoxicity.		circTet1	hsa_circ_TET1		tauopathy	MONDO:0005574	tauopathy	up-regulated	ISH; RNA-seq	"In MAPT tauIVS10+16 iPSC-derived neurons/cerebral organoids (tauopathy model), circTet1 is increased and localizes to nuclear invaginations, where it colocalizes with m6A, linking tau dysfunction to altered circRNA abundance and nuclear envelope pleomorphisms."	0.2465
38329551	Journal of cancer research and clinical oncology	2024	CircBRIP1: a plasma diagnostic marker for non-small-cell lung cancer.		circBRIP1 / circcBRIP1	hsa_circ_BRIP1	BRIP1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"circBRIP1 is up-regulated in NSCLC tissues, cell lines, and patient plasma and shows diagnostic value (ROC AUC reported). It localizes to both nucleus and cytoplasm (nucleus-predominant) and is bioinformatically predicted to function via RBP interactions and a circRNA_miRNA_mRNA ceRNA network, with enrichment suggesting immune-related involvement."	0.7038
38331765	Cellular & molecular biology letters	2024	CircMAST1 inhibits cervical cancer progression by hindering the N4-acetylcytidine modification of YAP mRNA.	hsa_circ_0049613	circMAST1	hsa_circ_MAST1	MAST1	cervical cancer / CC	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR; Microarray	"circMAST1 is down-regulated in cervical cancer and acts as a tumor suppressor. It binds and sequesters NAT10, reducing NAT10-mediated ac4C modification of YAP mRNA, which decreases YAP mRNA stability and inhibits tumor growth and lymph node metastasis."	0.8861
38333774	International journal of chronic obstructive pulmonary disease	2024	Circular RNA_0025843 Alleviated Cigarette Smoke Extract Induced Bronchoalveolar Epithelial Cells Ferroptosis.	hsa_circ_0025843	Circular RNA_0025843	hsa_circ_FGD4	FGD4	cigarette smoke extract (CSE)-induced bronchoalveolar epithelial cell injury / CSE-induced BEAS-2B cells ferroptosis	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR; RNA-seq	"In CSE-treated BEAS-2B cells, hsa_circ_0025843 is up-regulated. siRNA knockdown of hsa_circ_0025843 alleviates CSE-induced ferroptosis-associated injury, accompanied by increased GPX4 and decreased ACSL4, suggesting a protective effect when suppressed."	0.4852
38338754	International journal of molecular sciences	2024	CircRNAome of Childhood Acute Lymphoblastic Leukemia: Deciphering Subtype-Specific Expression Profiles and Involvement in TCF3::PBX1 ALL.	hsa_circ_0001098	circBARD1	hsa_circ_BARD1	BARD1	childhood B-cell acute lymphoblastic leukemia	MONDO:0000872	B-cell childhood acute lymphoblastic leukemia	up-regulated	RT-qPCR; RNA-seq	"circBARD1 (hsa_circ_0001098) is overexpressed in TCF3::PBX1 childhood B-ALL, is mainly cytoplasmic, and promotes leukemogenic phenotypes (proliferation and migration) in 697 cells. It is regulated by the RBP NUDT21 and is proposed to activate p38/MAPK signaling via hsa-miR-153-5p, with reduced p38 and STAT3 phosphorylation upon circBARD1 knockdown."	0.6157
38339175	International journal of molecular sciences	2024	"ADAMTS Gene-Derived circRNA Molecules in Non-Small-Cell Lung Cancer: Expression Profiling, Clinical Correlations and Survival Analysis."	hsa_circ_0004418		hsa_circ_ADAMTS6	ADAMTS6	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	unknown	RT-qPCR	"hsa_circ_0004418 (ADAMTS6-derived) was profiled in NSCLC lung tissues by RT-qPCR. The study used bioinformatic prediction supporting a potential circRNA/miRNA/mRNA interaction affecting ADAMTS6 transcript stability, but no specific functional phenotype or confirmed downstream miRNA/mRNA targets were experimentally validated."	0.4685
38339175	International journal of molecular sciences	2024	"ADAMTS Gene-Derived circRNA Molecules in Non-Small-Cell Lung Cancer: Expression Profiling, Clinical Correlations and Survival Analysis."	hsa_circ_0072676		hsa_circ_ADAMTS6	ADAMTS6	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	dysregulated	RT-qPCR	"hsa_circ_0072676 (ADAMTS6-derived) showed subtype-associated dysregulation in NSCLC, with higher expression in large-cell lung cancer compared to squamous cell carcinoma. Its predicted mechanism involved a potential circRNA/miRNA/mRNA interaction impacting ADAMTS6 transcript stability, but this was not supported by circRNA-host expression correlation in this cohort."	0.4685
38339175	International journal of molecular sciences	2024	"ADAMTS Gene-Derived circRNA Molecules in Non-Small-Cell Lung Cancer: Expression Profiling, Clinical Correlations and Survival Analysis."	hsa_circ_0066444		hsa_circ_ADAMTS9	ADAMTS9	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	unknown	RT-qPCR	hsa_circ_0066444 (ADAMTS9-derived) was measured in NSCLC lung tissues by RT-qPCR and included in database-based miRNA binding predictions. The study did not confirm a specific circRNA/miRNA/mRNA interaction network or link this circRNA to clinical features or prognosis in NSCLC.	0.4685
38339175	International journal of molecular sciences	2024	"ADAMTS Gene-Derived circRNA Molecules in Non-Small-Cell Lung Cancer: Expression Profiling, Clinical Correlations and Survival Analysis."	hsa_circ_0006624		hsa_circ_ADAMTS12	ADAMTS12	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	hsa_circ_0006624 (ADAMTS12-derived) was down-regulated in NSCLC tumors that infiltrated surrounding tissues and its expression correlated with ADAMTS12 mRNA in clinical lung tissue samples. The study did not experimentally establish specific miRNA targets or downstream pathways for this circRNA.	0.4685
38339175	International journal of molecular sciences	2024	"ADAMTS Gene-Derived circRNA Molecules in Non-Small-Cell Lung Cancer: Expression Profiling, Clinical Correlations and Survival Analysis."	hsa_circ_0072119		hsa_circ_ADAMTS12	ADAMTS12	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	hsa_circ_0072119 (ADAMTS12-derived) was down-regulated in NSCLC tumors with infiltration of surrounding tissues and strongly correlated with ADAMTS12 mRNA expression in patient lung tissue samples. No specific miRNA targets or downstream pathways were experimentally validated for this circRNA.	0.4685
38341427	Cell death discovery	2024	circEPB41L2 blocks the progression and metastasis in non-small cell lung cancer by promoting TRIP12-triggered PTBP1 ubiquitylation.	hsa_circ_0077837	circEPB41L2	hsa_circ_EPB41L2	EPB41L2	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	"circEPB41L2 is down-regulated in NSCLC and acts as a tumor suppressor. It serves as a scaffold to recruit TRIP12 to PTBP1, promoting PTBP1 ubiquitination and proteasomal degradation, thereby inhibiting aerobic glycolysis and EMT and reducing NSCLC growth and metastasis."	0.8872
38343838	medRxiv : the preprint server for health sciences	2024	Circulating blood circular RNA in Parkinson's Disease; a systematic study.		circAFF2	hsa_circ_AFF2	AFF2	Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	up-regulated	RNA-seq	circAFF2 is differentially accumulated (up-regulated) in PD blood in cross-sectional analyses and is one of five high-confidence circRNAs highlighted by the study. It shows significant correlations with motor severity (UPDRS-III) and cognitive score (MoCA) and is evaluated as part of circRNA biomarker efforts.	0.348
38343838	medRxiv : the preprint server for health sciences	2024	Circulating blood circular RNA in Parkinson's Disease; a systematic study.		circETFA	hsa_circ_ETFA	ETFA	Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	down-regulated	RNA-seq	circETFA is decreased in blood of sporadic PD participants versus controls and is one of the five high-confidence circRNAs followed up by the study. Its broader biological context was explored via predicted miRNA targets and pathway enrichment analyses.	0.348
38343838	medRxiv : the preprint server for health sciences	2024	Circulating blood circular RNA in Parkinson's Disease; a systematic study.		circFAM13B	hsa_circ_FAM13B	FAM13B	Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	down-regulated	RNA-seq	"circFAM13B is down-regulated in PD blood and remains significantly associated with PD even after jointly modeling its host gene¡¯s linear transcript, suggesting an association beyond simple host-gene expression changes. It is among the study¡¯s five high-confidence blood circRNAs and was further explored via predicted miRNA targets and pathway enrichment."	0.348
38343838	medRxiv : the preprint server for health sciences	2024	Circulating blood circular RNA in Parkinson's Disease; a systematic study.		circSPI1	hsa_circ_SPI1	SPI1	Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	up-regulated	RNA-seq	circSPI1 is up-regulated in PD blood and is among the five high-confidence PD-associated circRNAs highlighted by the study. It correlates with motor severity (UPDRS-III) and was further contextualized through in-silico miRNA targeting and pathway enrichment analyses.	0.348
38343838	medRxiv : the preprint server for health sciences	2024	Circulating blood circular RNA in Parkinson's Disease; a systematic study.		circSUZ12	hsa_circ_SUZ12	SUZ12	Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	down-regulated	RNA-seq	"circSUZ12 is down-regulated in PD blood and is among the study¡¯s five high-confidence PD-associated circRNAs. The study further contextualized it via in-silico miRNA target prediction, circRNA_miRNA correlation filtering, and pathway enrichment analyses."	0.348
38355583	Molecular cancer	2024	ZNF460-mediated circRPPH1 promotes TNBC progression through ITGA5-induced FAK/PI3K/AKT activation in a ceRNA manner.	hsa_circ_000166	hsa_circRNA_000166 / circRPPH1	hsa_circ_RPPH1	RPPH1	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; RNA-seq	"circRPPH1 is upregulated in TNBC and its high expression predicts poor overall survival. Functionally, it promotes proliferation, migration/invasion, EMT, cell-cycle progression and tumor growth/metastasis. Mechanistically, ZNF460 increases circRPPH1 expression, and circRPPH1 sponges miR-326 to upregulate ITGA5 and activate FAK/PI3K/AKT signaling."	0.8942
38357830	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2024	Integrated Multiomics Reveals Silencing of has_circ_0006646 Promotes TRIM21-Mediated NCL Ubiquitination to Inhibit Hepatocellular Carcinoma Metastasis.	hsa_circ_0006646	circ0006646	hsa_circ_PTK2	PTK2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circ0006646 is up-regulated in HCC and promotes invasion/migration and metastasis. It binds NCL and blocks TRIM21-mediated K48-linked polyubiquitination, stabilizing NCL protein; stabilized NCL suppresses p53 translation and reduces E-cadherin, facilitating EMT and metastasis. High circ0006646 is associated with advanced TNM stage and poorer overall survival, and its knockdown shows therapeutic potential in xenograft/PDX models."	0.8988
38358587	Biochemical genetics	2024	CircRNA ITCH Inhibits Epithelial-Mesenchymal Transformation and Promotes Apoptosis in Papillary Thyroid Carcinoma via miR-106a-5p/JAZF1 Axis.		CircRNA ITCH / circ-ITCH	hsa_circ_ITCH	ITCH	papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR	"circ-ITCH is down-regulated in papillary thyroid carcinoma tissues/cells and functions as a tumor suppressor. It inhibits EMT-associated migration/invasion and promotes apoptosis, at least partly via the circ-ITCH/miR-106a-5p/JAZF1 regulatory axis."	0.6777
38360615	Journal of nanobiotechnology	2024	Exosomes secreted by Fusobacterium nucleatum-infected colon cancer cells transmit resistance to oxaliplatin and 5-FU by delivering hsa_circ_0004085.	hsa_circ_0004085		hsa_circ_EPHB2	EPHB2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0004085 is upregulated in Fn-infected CRC and enriched in tumor-derived exosomes, which transfer it to recipient cells. It binds RRBP1 to stabilize GRP78 mRNA and promotes ATF6p50 nuclear translocation, relieving ER stress, inhibiting apoptosis, and promoting oxaliplatin/5-FU resistance. High plasma levels predict poor chemotherapy response and shorter PFS."	0.8793
38360682	Molecular cancer	2024	A novel peptide PDHK1-241aa encoded by circPDHK1 promotes ccRCC progression via interacting with PPP1CA to inhibit AKT dephosphorylation and activate the AKT-mTOR signaling pathway.	hsa_circ_0057090	circPDHK1	hsa_circ_PDHK1	PDHK1	Clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR; Microarray	"circPDHK1 is upregulated in ccRCC and is associated with advanced clinicopathologic features. It functions mainly by encoding the peptide PDHK1-241aa, which binds PPP1CA, relocates it to the nucleus, inhibits AKT dephosphorylation, and activates AKT-mTOR signaling to promote malignant phenotypes."	0.8657
38361605	iScience	2024	CircZCCHC2 decreases pirarubicin sensitivity and promotes triple-negative breast cancer development via the miR-1200/TPR axis.	hsa_circ_0000854	CircZCCHC2	hsa_circ_ZCCHC2	ZCCHC2	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"CircZCCHC2 (hsa_circ_0000854, from ZCCHC2) is upregulated in TNBC tissues, TNBC cell lines, and patient plasma exosomes. It promotes proliferation, migration, invasion and EMT and enhances xenograft tumor growth. Mechanistically, it primarily localizes in the cytoplasm and sponges miR-1200 to upregulate TPR, activating the RAS-RAF-MEK-ERK pathway and decreasing sensitivity to pirarubicin (THP)."	0.8709
38361743	Frontiers in molecular neuroscience	2024	Transcriptome profile analysis in spinal cord injury rats with transplantation of menstrual blood-derived stem cells.		circ_003035			spinal cord injury / SCI	MONDO:0043797	spinal cord injury	unknown	RT-qPCR	circ_003035 was identified as a differentially expressed circRNA in injured rat T10 spinal cord after MenSCs treatment versus SCI and its expression trend was validated by qRT-PCR consistent with RNA-seq. No specific downstream miRNA/mRNA mechanism or functional assays were reported for this circRNA.	0.1904
38361743	Frontiers in molecular neuroscience	2024	Transcriptome profile analysis in spinal cord injury rats with transplantation of menstrual blood-derived stem cells.		circ_005247			spinal cord injury / SCI	MONDO:0043797	spinal cord injury	unknown	RT-qPCR	circ_005247 was reported as differentially expressed in injured rat T10 spinal cord after MenSCs treatment versus SCI and was among circRNAs validated by qRT-PCR consistent with RNA-seq. No specific ceRNA partners or functional role was experimentally defined for this circRNA.	0.1904
38361743	Frontiers in molecular neuroscience	2024	Transcriptome profile analysis in spinal cord injury rats with transplantation of menstrual blood-derived stem cells.		circ_001055			spinal cord injury / SCI	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR; RNA-seq	circ_001055 was up-regulated in MenSCs-treated rat injured spinal cord compared with SCI and its differential expression trend was validated by qRT-PCR. The study did not report specific miRNA/mRNA targets or functional effects for circ_001055.	0.3588
38361743	Frontiers in molecular neuroscience	2024	Transcriptome profile analysis in spinal cord injury rats with transplantation of menstrual blood-derived stem cells.		circ_002391			spinal cord injury / SCI	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR; RNA-seq	circ_002391 was up-regulated in MenSCs-treated rat injured spinal cord compared with SCI and was validated by qRT-PCR as consistent with RNA-seq. The paper did not define specific mechanistic partners or functional phenotypes for circ_002391.	0.1904
38361743	Frontiers in molecular neuroscience	2024	Transcriptome profile analysis in spinal cord injury rats with transplantation of menstrual blood-derived stem cells.		circ_004896			spinal cord injury / SCI	MONDO:0043797	spinal cord injury	unknown	RNA-seq	circ_004896 was included in the constructed SCI ceRNA network and was predicted to compete for miR-331-5p with lncRNAs (MSTRG.19470.3 and 18869.2). The study did not experimentally validate circ_004896 expression by qRT-PCR or test its functional effects.	0.1768
38361751	Oncology research	2024	CircTHSD4 promotes the malignancy and docetaxel (DTX) resistance in prostate cancer by regulating miR-203/HMGA2 axis.	hsa_circ_0005203	circ_0005203 / circTHSD4	hsa_circ_THSD4	THSD4	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circTHSD4 (hsa_circ_0005203), derived from THSD4, is up-regulated in prostate cancer and mainly localized in the cytoplasm. It promotes proliferation/migration/invasion and xenograft tumor growth and increases docetaxel resistance by sponging miR-203 to upregulate HMGA2; high expression is associated with poorer overall survival."	0.8557
38365721	Molecular cancer	2024	CircPCNXL2 promotes tumor growth and metastasis by interacting with STRAP to regulate ERK signaling in intrahepatic cholangiocarcinoma.	hsa_circ_0016956	circPCNXL2	hsa_circ_PCNXL2	PCNXL2	intrahepatic cholangiocarcinoma / ICC	MONDO:0003210	intrahepatic cholangiocarcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"circPCNXL2 is up-regulated in intrahepatic cholangiocarcinoma and promotes proliferation, migration, tumor growth and metastasis. Mechanistically, it binds STRAP to enhance STRAP_MEK1/2 interactions and ERK/MAPK activation, and also sponges miR-766-3p to upregulate SRSF1, further promoting ERK phosphorylation; circPCNXL2 overexpression reduces trametinib anti-tumor efficacy in vivo."	0.9026
38366146	Oncogene	2024	CircUSP1 as a novel marker promotes gastric cancer progression via stabilizing HuR to upregulate USP1 and Vimentin.	hsa_circ_0000080	circUSP1 / hsa_circ_000613	hsa_circ_USP1	USP1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circUSP1 is upregulated in gastric cancer tissues/cells and promotes proliferation, invasion/metastasis and tumor growth. It predominantly localizes in the cytoplasm, binds HuR (mainly via RRM1) and stabilizes HuR by inhibiting beta-TrCP-mediated ubiquitination, thereby increasing HuR-dependent post-transcriptional upregulation of USP1 and Vimentin and contributing to poor prognosis and diagnostic potential in plasma."	0.9018
38370378	Journal of Cancer	2024	Exosome-mediated delivery of artificial circular RNAs for gene therapy of bladder cancer.		acircRNA-3			bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	unknown	RT-qPCR	"This study constructs an artificial circular RNA device (acircRNA-3) composed of beta-catenin and NF-kappaB aptamer units that binds and inhibits these oncogenic factors in bladder cancer cells. Exosome delivery using CD63-HuR and ARE tags enables efficient transfer of acircRNA, leading to reduced downstream gene expression and suppression of proliferation and migration while promoting apoptosis in vitro."	0.5223
38378679	Cell death & disease	2024	Hsa_circ_0007990 promotes breast cancer growth via inhibiting YBX1 protein degradation to activate E2F1 transcription.	hsa_circ_0007990	circPGAP3	hsa_circ_PGAP3	PGAP3	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"In breast cancer, hsa_circ_0007990 (circPGAP3) is up-regulated in tissues and cell lines and promotes tumor cell growth in vitro and in vivo. It predominantly localizes to the nucleus, binds YBX1, inhibits ubiquitin/proteasome-dependent degradation of YBX1, and thereby increases YBX1-dependent E2F1 transcription to drive proliferation/cell-cycle progression."	0.8647
38383334	BMC cancer	2024	Hsa_circ_0005397 promotes hepatocellular carcinoma progression through EIF4A3.	hsa_circ_0005397	circ_0005397	hsa_circ_RHOT1	RHOT1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"hsa_circ_0005397 is up-regulated in hepatocellular carcinoma tissues and cell lines and enhances HCC cell proliferation, colony formation, migration/invasion, and cell-cycle progression. Mechanistically, it interacts with the RNA-binding protein EIF4A3, and EIF4A3 knockdown reduces hsa_circ_0005397 levels and reverses its pro-tumor phenotypes. It shows potential diagnostic value (ROC AUC ~0.88) and correlates with tumor size and TNM stage."	0.8162
38383479	Journal of experimental & clinical cancer research : CR	2024	A tumor suppressor protein encoded by circKEAP1 inhibits osteosarcoma cell stemness and metastasis by promoting vimentin proteasome degradation and activating anti-tumor immunity.	hsa_circ_0049271	circKEAP1	hsa_circ_KEAP1	KEAP1	Osteosarcoma / OS	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; Microarray	"circKEAP1 (hsa_circ_0049271), derived from KEAP1 exon 2, is down-regulated in osteosarcoma and its higher expression is associated with better overall survival. It suppresses OS proliferation, migration/invasion, stemness and metastasis by encoding KEAP1-259aa, which promotes ARIH1-dependent proteasomal degradation of vimentin, and it also binds RIG-I to activate IFN-related anti-tumor immune signaling; m6A modification decreases circKEAP1 stability."	0.9012
38384181	Gut and liver	2024	Tumor-Derived Exosomal Circular RNA Pinin Induces FGF13 Expression to Promote Colorectal Cancer Progression through miR-1225-5p.	hsa_circ_0101802	circ-PNN / circ_0101802	hsa_circ_PNN	PNN	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"Exosomal circ-PNN is up-regulated in plasma exosomes from colorectal cancer patients and promotes CRC cell proliferation, migration/invasion while inhibiting apoptosis, as well as enhancing xenograft tumor growth. Mechanistically, circ-PNN functions as a ceRNA sponge for miR-1225-5p to increase FGF13 expression, forming a circ-PNN/miR-1225-5p/FGF13 regulatory axis."	0.8299
38388473	Arthritis research & therapy	2024	Fibroblast-like synoviocytes-derived exosomal circFTO deteriorates rheumatoid arthritis by enhancing N6-methyladenosine modification of SOX9 in chondrocytes.	hsa_circ_0005941	circFTO	hsa_circ_FTO	FTO	Rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; RNA-seq	"Exosomal circFTO derived from RA fibroblast-like synoviocytes is up-regulated in RA and aggravates disease by impairing chondrocyte proliferation/migration and anabolic activity while promoting apoptosis and catabolism. Mechanistically, circFTO interacts with and promotes assembly of the WTAP/METTL3/METTL14 m6A writer complex, increasing m6A on SOX9 mRNA and reducing SOX9 mRNA stability via YTHDF2-dependent decay. circFTO knockdown alleviates arthritis phenotypes in the CIA mouse model."	0.8354
38394156	Archives of endocrinology and metabolism	2024	CircSEMA6A upregulates PRRG4 by targeting MiR-520h and recruiting ELAVL1 to affect cell invasion and migration in papillary thyroid carcinoma.		circSEMA6A / circRNA_103923	hsa_circ_SEMA6A	SEMA6A	papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circSEMA6A is up-regulated in papillary thyroid carcinoma and promotes migration and invasion (and tumor growth in vivo). Mechanistically, it sponges miR-520h to increase PRRG4 and also recruits ELAVL1 to stabilize PRRG4 mRNA, thereby driving PTC progression."	0.7939
38395751	Cellular & molecular biology letters	2024	N6-methyladenosine-modified circ_104797 sustains cisplatin resistance in bladder cancer through acting as RNA sponges.		circ_104797 / circRNA_104797	hsa_circ_TLE4	TLE4	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"circ_104797 (from TLE4 exons 6_7) is up-regulated in bladder cancer, especially in cisplatin-resistant cells, and high expression is associated with worse overall survival. m6A modification increases circ_104797 stability; demethylation via dCas13b-ALKBH5 reduces circ_104797, suppressing proliferation/migration and increasing apoptosis, partly through sponging miR-103a and miR-660-3p."	0.8726
38400818	Thoracic cancer	2024	CircCPA4 induces ASCT2 expression to promote tumor property of non-small cell lung cancer cells in a miR-145-5p-dependent manner.	hsa_circ_0082374	circCPA4	hsa_circ_CPA4	CPA4	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circCPA4 is up-regulated in NSCLC tissues/cells and promotes malignant phenotypes (proliferation, migration, invasion) while inhibiting apoptosis. Mechanistically, circCPA4 sponges miR-145-5p to increase ASCT2 expression, enhancing intracellular glutamine/glutamate/alpha-KG levels and supporting glutamine metabolism; circCPA4 knockdown suppresses tumor growth in a xenograft model."	0.8172
38407616	Journal of cancer research and clinical oncology	2024	Helicobacter pylori upregulates circPGD and promotes development of gastric cancer.	hsa_circ_0009735	circPGD	hsa_circ_PGD	PGD	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"In H. pylori-related gastric cancer, circPGD (hsa_circ_0009735) is upregulated in infected cells and patient gastric tissues. Functionally, circPGD promotes proliferation, migration and EMT, enhances NF-kappaB-associated inflammatory responses, and inhibits apoptosis."	0.5821
38409914	Thoracic cancer	2024	CircSEPT9 promotes breast cancer progression by regulating PTBP3 expression via sponging miR-625-5p.	hsa_circ_0005320	CircSEPT9 / circRNA Septin 9	hsa_circ_SEPT9	SEPT9	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circSEPT9 is up-regulated in breast cancer tissues/cells and acts as an oncogenic circRNA. It promotes proliferation, migration, EMT and glycolysis and inhibits apoptosis by sponging miR-625-5p, thereby relieving repression of PTBP3 and supporting tumor growth in vivo."	0.795
38418741	Parasitology research	2024	Expression profiles of host miRNAs and circRNAs and ceRNA network during Toxoplasma gondii lytic cycle.	hsa_circ_0081083				Toxoplasma gondii infection / T. gondii infection / toxoplasmosis	MONDO:0005989	toxoplasmosis	dysregulated	RT-qPCR; RNA-seq	hsa-circ_0081083 was identified as a differentially expressed circRNA during T. gondii infection in HFF cells and its differential expression was validated by qRT-PCR consistent with RNA-seq results.	0.1904
38418741	Parasitology research	2024	Expression profiles of host miRNAs and circRNAs and ceRNA network during Toxoplasma gondii lytic cycle.	hsa_circ_0133744				Toxoplasma gondii infection / T. gondii infection / toxoplasmosis	MONDO:0005989	toxoplasmosis	dysregulated	RT-qPCR; RNA-seq	"hsa-circ_0133744 was identified as a differentially expressed circRNA during T. gondii infection in HFF cells and its differential expression was validated by qRT-PCR, consistent with RNA-seq."	0.1904
38418741	Parasitology research	2024	Expression profiles of host miRNAs and circRNAs and ceRNA network during Toxoplasma gondii lytic cycle.	hsa_circ_0083081				Toxoplasma gondii infection / T. gondii infection / toxoplasmosis	MONDO:0005989	toxoplasmosis	dysregulated	RT-qPCR; RNA-seq	"hsa-circ_0083081 is a differentially expressed circRNA during T. gondii infection in HFF cells, co-expressed across multiple post-infection time points and validated by qRT-PCR consistent with RNA-seq."	0.1904
38425655	Gastroenterology report	2024	Deregulation of circRNA hsa_circ_0009109 promotes tumor growth and initiates autophagy by sponging miR-544a-3p in gastric cancer.	hsa_circ_0009109	hsa_circDCAF6_003	hsa_circ_DCAF6	DCAF6	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"hsa_circ_0009109 (circDCAF6_003) is down-regulated in gastric cancer tissues and cell lines and acts as a tumor suppressor. It mainly localizes to the cytoplasm, sponges miR-544a-3p, upregulates BCL-2, and inhibits autophagy, thereby restraining proliferation, migration/invasion, and tumor growth."	0.8072
38429642	BMC cancer	2024	The novel circRNA circ_0045881 inhibits cell proliferation and invasion by targeting mir-214-3p in triple-negative breast cancer.	hsa_circ_0045881	circ_0045881			triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0045881 is down-regulated in TNBC tissues and cell lines. Its overexpression suppresses TNBC cell invasion, migration, and proliferation, at least partly by binding (sponging) miR-214-3p as shown by luciferase and RIP assays."	0.725
38429830	Cancer cell international	2024	The circRNA hsa-circ-0013561 regulates head and neck squamous cell carcinoma development via the miR-7-5p/PDK3 axis.	hsa_circ_0013561				head and neck squamous cell carcinoma / HNSCC	MONDO:0010150	head and neck squamous cell carcinoma	up-regulated	RT-qPCR; ISH	"hsa-circ-0013561 is up-regulated in HNSCC and mainly cytoplasmic. Its silencing suppresses proliferation, migration/invasion and metastasis while promoting apoptosis and G1 arrest. Mechanistically, it drives HNSCC progression via a miR-7-5p/PDK3 ceRNA axis, and is proposed as a diagnostic biomarker/therapeutic target."	0.6838
38431720	Cell death discovery	2024	CircHIPK3 regulates fatty acid metabolism through miR-637/FASN axis to promote esophageal squamous cell carcinoma.	hsa_circ_0000284	CircHIPK3	hsa_circ_HIPK3	HIPK3	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circHIPK3 is up-regulated in ESCC tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion) and xenograft tumor growth. It functions mainly in the cytoplasm as a ceRNA that sponges miR-637 to de-repress FASN, enhancing fatty acid metabolism; ASO-mediated circHIPK3 inhibition suppresses ESCC, suggesting therapeutic potential."	0.7966
38434522	HemaSphere	2024	"Exploring the molecular biomarker utility of circCCT3 in multiple myeloma: A favorable prognostic indicator, particularly for R-ISS II patients."		circCCT3	hsa_circ_CCT3	CCT3	multiple myeloma / MM	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR	circCCT3 is up-regulated in CD138+ plasma cells from MM compared with SMM and shows diagnostic separation of MM vs SMM by ROC analysis. High circCCT3 expression is associated with better PFS and OS and further stratifies R-ISS stage II patients as a favorable prognostic biomarker.	0.6656
38434987	Journal of Cancer	2024	Identification of a lncRNA/circRNA-miRNA-mRNA network in Nasopharyngeal Carcinoma by deep sequencing and bioinformatics analysis.	hsa_circ_0001359				Nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RNA-seq	hsa_circ_0001359 was identified as a differentially expressed circRNA (higher in NPC tumor tissues than normal) and included in a predicted lncRNA/circRNA-miRNA-mRNA ceRNA network constructed by RNA-seq and bioinformatics analyses.	0.1768
38434987	Journal of Cancer	2024	Identification of a lncRNA/circRNA-miRNA-mRNA network in Nasopharyngeal Carcinoma by deep sequencing and bioinformatics analysis.	hsa_circ_0002458				Nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RNA-seq	has-circ_0002458 (also written as has_circ_0002458) was identified as a differentially expressed circRNA (higher in NPC tumor tissues than normal) and included in a predicted lncRNA/circRNA-miRNA-mRNA ceRNA network based on circBank and sequencing-derived DEcircRNAs.	0.1768
38434987	Journal of Cancer	2024	Identification of a lncRNA/circRNA-miRNA-mRNA network in Nasopharyngeal Carcinoma by deep sequencing and bioinformatics analysis.	hsa_circ_0008967				Nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RNA-seq	hsa_circ_0008967 was identified as a differentially expressed circRNA (higher in NPC tumor tissues than normal) and incorporated into a predicted lncRNA/circRNA-miRNA-mRNA ceRNA network generated from sequencing data and database-based interaction predictions.	0.1768
38439965	iScience	2024	CircTBC1D22A inhibits the progression of colorectal cancer through autophagy regulated via miR-1825/ATG14 axis.	hsa_circ_0001251	circTBC1D22A	hsa_circ_TBC1D22A	TBC1D22A	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"circTBC1D22A is down-regulated in colorectal cancer tissues and functions as a tumor suppressor. It sponges miR-1825 to restore ATG14 expression, promoting autophagy and thereby inhibiting CRC cell proliferation, migration, and metastasis; it also counteracts AKT-mTOR activation."	0.7949
38440120	Analytical cellular pathology (Amsterdam)	2024	Hsa_circ_0000190 Promotes NSCLC Cell Resistance to Cisplatin via the Modulation of the miR-1253/IL-6 Axis.	hsa_circ_0000190		hsa_circ_CNIH4	CNIH4	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0000190 is up-regulated in cisplatin-resistant NSCLC tissues and resistant cell sublines and promotes DDP chemoresistance. Mechanistically, it mainly localizes to the cytoplasm and acts as a sponge for miR-1253, relieving repression of IL-6 and thereby increasing IL-6 levels to support resistance."	0.7726
38443362	Cell death & disease	2024	CircNUP54 promotes hepatocellular carcinoma progression via facilitating HuR cytoplasmic export and stabilizing BIRC3 mRNA.	hsa_circ_0070039	circNUP54	hsa_circ_NUP54	NUP54	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circNUP54 (hsa_circ_0070039), derived from NUP54, is up-regulated in HCC and predicts poor prognosis. It promotes HCC proliferation, migration/invasion and tumor growth/metastasis by binding HuR, enhancing HuR cytoplasmic export and stabilizing BIRC3 mRNA, which activates NF-kappaB signaling."	0.8854
38443846	BMC nephrology	2024	Knockdown of circ-Gatad1 alleviates LPS induced HK2 cell injury via targeting miR-22-3p/TRPM7 axis in septic acute kidney.		circ-Gatad1	hsa_circ_Gatad1	Gatad1	septic acute kidney injury	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR; RNA-seq	"circ-Gatad1 is up-regulated in serum from septic AKI patients and in LPS-treated HK2 cells. It localizes mainly to the cytoplasm and promotes LPS-induced HK2 injury (reduced proliferation, increased apoptosis, ROS, and inflammatory cytokines) by sponging miR-22-3p to increase TRPM7; circ-Gatad1 knockdown is protective."	0.7566
38445791	Journal of cellular and molecular medicine	2024	circ_HMGCS1 modulates hepatocellular carcinoma chemoresistance via miR-338-5p/IL-7 pathway.	hsa_circ_0072391	circ_0072391 / circ_HMGCS1	hsa_circ_HMGCS1	HMGCS1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ_HMGCS1 is up-regulated in cisplatin-resistant HCC cell lines and promotes chemoresistance by reducing cisplatin-induced apoptosis and sustaining proliferation. Mechanistically, it acts as a sponge for miR-338-5p to upregulate IL-7, forming a circ_HMGCS1/miR-338-5p/IL-7 axis that contributes to resistance and may relate to immune regulation via IL-7."	0.7884
38454465	Journal of experimental & clinical cancer research : CR	2024	TGF-beta-activated circRYK drives glioblastoma progression by increasing VLDLR mRNA expression and stability in a ceRNA- and RBP-dependent manner.	hsa_circ_0005768	circRYK / circRNA RYK	hsa_circ_RYK	RYK	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; RNA-seq	"circRYK is up-regulated in glioblastoma/glioma and correlates with poor prognosis. It promotes EMT, migration/invasion and glioma stem-like cell maintenance by increasing VLDLR expression via sponging miR-330-5p and by binding HuR to enhance VLDLR mRNA stability and HuR cytoplasmic accumulation."	0.8728
38454507	Biology direct	2024	Dysregulation and antimetastatic function of circLRIG1 modulated by miR-214-3p/LRIG1 axis in bladder carcinoma.		circLRIG1	hsa_circ_LRIG1	LRIG1	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"circLRIG1 is down-regulated in bladder carcinoma and mainly localizes to the cytoplasm. It suppresses proliferation and metastasis and promotes apoptosis by acting as a ceRNA that sponges miR-214-3p, thereby increasing LRIG1 expression; low circLRIG1 is associated with worse overall survival."	0.8661
38459511	Molecular cancer	2024	circNOX4 activates an inflammatory fibroblast niche to promote tumor growth and metastasis in NSCLC via FAP/IL-6 axis.	hsa_circ_0023988	circNOX4 / circ_0023988	hsa_circ_NOX4	NOX4	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circNOX4 is a CAF-enriched circRNA in NSCLC that drives NF-to-CAF activation and enhances pro-metastatic functions. It acts in the cytoplasm as a ceRNA sponging miR-329-5p to increase FAP, which elevates IL-6 secretion and promotes tumor growth and metastasis; high circNOX4 is associated with poor patient survival."	0.8846
38459513	Journal of translational medicine	2024	CircGLIS3 promotes gastric cancer progression by regulating the miR-1343-3p/PGK1 pathway and inhibiting vimentin phosphorylation.	hsa_circ_0002874	circGLIS3	hsa_circ_GLIS3	GLIS3	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"circGLIS3 (hsa_circ_0002874) is up-regulated in gastric cancer and promotes tumor growth and metastasis. It sponges miR-1343-3p to upregulate PGK1 and activate PI3K/AKT signaling, and it also binds VIMENTIN to reduce Ser83 phosphorylation. circGLIS3 is transported via exosomes to neighboring cancer cells and macrophages, enhancing invasion and inducing M2 polarization; EIF4A3 promotes its biogenesis."	0.8546
38459596	Molecular cancer	2024	Exosome circATP8A1 induces macrophage M2 polarization by regulating the miR-1-3p/STAT6 axis to promote gastric cancer progression.	hsa_circ_0069616	circATP8A1 / hsa_circRNA_0069616	hsa_circ_ATP8A1	ATP8A1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circATP8A1 is upregulated in gastric cancer tissues and plasma exosomes and promotes gastric cancer progression. It is delivered via exosomes to macrophages, where it sponges miR-1-3p to activate STAT6 signaling, inducing M2 polarization that enhances tumor growth and migration; high circATP8A1 is associated with worse prognosis."	0.8884
38461272	Molecular cancer	2024	Bladder-cancer-derived exosomal circRNA_0013936 promotes suppressive immunity by up-regulating fatty acid transporter protein 2 and down-regulating receptor-interacting protein kinase 3 in PMN-MDSCs.	hsa_circ_0013936	circRNA_0013936 / circRNA_ 0013936			bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; RNA-seq	"In bladder cancer, exosomal circRNA_0013936 is up-regulated and enhances PMN-MDSC immunosuppressive activity. It sponges miR-320a and miR-301b-3p to regulate JAK2 (JAK2/pSTAT5) and CREB1, leading to increased FATP2 and decreased RIPK3, thereby suppressing CD8+ T-cell function."	0.8416
38461489	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2024	CircFBXW4 Suppresses Colorectal Cancer Progression by Regulating the MiR-338-5p/SLC5A7 Axis.	hsa_circ_0008362	circFBXW4	hsa_circ_FBXW4	FBXW4	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"circFBXW4 is down-regulated in colorectal cancer and functions as a tumor suppressor. It mainly localizes to the cytoplasm and acts as a ceRNA by sponging miR-338-5p, thereby relieving repression of SLC5A7 and inhibiting CRC cell proliferation, migration/invasion while promoting apoptosis, including suppression of xenograft tumor growth."	0.8888
38462601	Journal of translational medicine	2024	Exosomal circRNAs in the plasma serve as novel biomarkers for IPF diagnosis and progression prediction.	hsa_circ_0044226	hsa_circRNA_102100	hsa_circ_CDC27	CDC27	idiopathic pulmonary fibrosis / IPF	MONDO:0800504	idiopathic pulmonary fibrosis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0044226 is up-regulated in plasma exosomes of IPF patients and further elevated in AE-IPF, showing strong diagnostic and progression-prediction potential. Functionally, it promotes TGFbeta1-associated myofibroblast activation/proliferation, while its knockdown reduces fibrosis-related proteins (alpha-SMA, FN, COL1)."	0.6758
38462601	Journal of translational medicine	2024	Exosomal circRNAs in the plasma serve as novel biomarkers for IPF diagnosis and progression prediction.	mmu_circ_0002687		mmu_circ_CDC27	CDC27	idiopathic pulmonary fibrosis / IPF	MONDO:0800504	idiopathic pulmonary fibrosis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0044226 is up-regulated in plasma exosomes of IPF patients and further elevated in AE-IPF, showing strong diagnostic and progression-prediction potential. Functionally, it promotes TGFbeta1-associated myofibroblast activation/proliferation, while its knockdown reduces fibrosis-related proteins (alpha-SMA, FN, COL1)."	0.6758
38462601	Journal of translational medicine	2024	Exosomal circRNAs in the plasma serve as novel biomarkers for IPF diagnosis and progression prediction.	hsa_circ_0004099	hsa_circRNA_100759	hsa_circ_DENND5A	DENND5A	Idiopathic Pulmonary Fibrosis / IPF	MONDO:0800504	idiopathic pulmonary fibrosis	up-regulated	RT-qPCR; Microarray	hsa_circ_0004099 is up-regulated in plasma exosomes of IPF patients and shows good diagnostic performance by ROC analysis. No downstream mechanism was investigated for this circRNA in the study.	0.4679
38462601	Journal of translational medicine	2024	Exosomal circRNAs in the plasma serve as novel biomarkers for IPF diagnosis and progression prediction.	hsa_circ_0008898	hsa_circRNA_100705	hsa_circ_OAT	OAT	Idiopathic Pulmonary Fibrosis / IPF	MONDO:0800504	idiopathic pulmonary fibrosis	up-regulated	RT-qPCR; Microarray	hsa_circ_0008898 is up-regulated in plasma exosomes of IPF patients and provides diagnostic biomarker value by ROC analysis. No mechanistic experiments were reported for this circRNA in the study.	0.4679
38464761	PeerJ	2024	Hsa_circ_0001615 downregulation inhibits esophageal cancer development through miR-142-5p/beta-catenin.	hsa_circ_0001615	circPHIP	hsa_circ_PHIP	PHIP	Esophageal cancer / EC	MONDO:0007576	esophageal cancer	up-regulated	RT-qPCR	"hsa_circ_0001615 is up-regulated in esophageal cancer tissues and cell lines. Its knockdown suppresses proliferation, colony formation, migration and invasion, and promotes apoptosis by directly sponging miR-142-5p and reducing beta-catenin expression, implicating a miR-142-5p/beta-catenin (Wnt/beta-catenin-related) mechanism."	0.7872
38468340	Journal of animal science and biotechnology	2024	High expression circRALGPS2 in atretic follicle induces chicken granulosa cell apoptosis and autophagy via encoding a new protein.		circRALGPS2	gga_circ_RALGPS2	RALGPS2	follicular atresia	MONDO:0005558	ovarian disorder	up-regulated	RT-qPCR; RNA-seq	"circRALGPS2 is up-regulated in atretic chicken follicles. It encodes a novel protein (circRALGPS2-212aa) that promotes granulosa cell apoptosis and autophagy by forming a complex involving PARP1 and HMGB1, thereby contributing to follicular atresia."	0.7938
38472174	Cell death discovery	2024	Hypoxia induced exosomal Circ-ZNF609 promotes pre-metastatic niche formation and cancer progression via miR-150-5p/VEGFA and HuR/ZO-1 axes in esophageal squamous cell carcinoma.	hsa_circ_0000615	Circ-ZNF609 / hsa_circ_000193	hsa_circ_ZNF609	ZNF609	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"Hypoxia increases Circ-ZNF609 levels in ESCC-derived exosomes, which are taken up by HUVECs. Exosomal Circ-ZNF609 promotes angiogenesis and vascular leakiness to support pre-metastatic niche formation and ESCC progression, via sponging miR-150-5p to increase VEGFA and via binding HuR to suppress translation of tight-junction mRNAs (ZO-1/Claudin-1/Occludin)."	0.7937
38473339	Cancers	2024	Circular STAG2 RNA Modulates Bladder Cancer Progression via miR-145-5p/TAGLN2 and Is Considered as a Biomarker for Recurrence.	hsa_circ_0139697	circSTAG2(16_25)	hsa_circ_STAG2	STAG2	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"In bladder cancer, hsa_circ_0139697 (circSTAG2(16_25)) is up-regulated in patient urine and in aggressive BCa cell lines, and higher urine levels are associated with recurrence. Functionally, it promotes proliferation, migration/motility, and invasion. Mechanistically, it sponges miR-145-5p to relieve repression of TAGLN2, increasing TAGLN2 expression."	0.7754
38473814	International journal of molecular sciences	2024	Identification of IGF-1 Effects on White Adipose Tissue and Hippocampus in Alzheimer's Disease Mice via Transcriptomic and Cellular Analysis.		circKsr2	mmu_circ_Ksr2	Ksr2	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR; RNA-seq	"In IGF-1-treated APP/PS2 Alzheimer¡¯s disease mice, circKsr2 is upregulated in the hippocampus and localizes mainly to the cytoplasm. Knockdown of circKsr2 in vivo decreases p53 and GFAP and increases SYP in the hippocampus, suggesting a regulatory role in AD-related hippocampal pathology and synaptic/astrocytic markers."	0.6628
38474064	International journal of molecular sciences	2024	CircMTA2 Drives Gastric Cancer Progression through Suppressing MTA2 Degradation via Interacting with UCHL3.	hsa_circ_0022462	circMTA2	hsa_circ_MTA2	MTA2	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circMTA2 (hsa_circ_0022462), derived from MTA2, is up-regulated in gastric cancer tissues and cell lines and promotes GC proliferation, migration/invasion, and metastasis while inhibiting apoptosis. Mechanistically, circMTA2 binds UCHL3 to reduce MTA2 ubiquitination and stabilize MTA2 protein, and it can be delivered via exosomes to enhance GC progression."	0.8794
38475969	European journal of medical research	2024	Hypoxia-induced circRNAs encoded by PPARA are highly expressed in human cardiomyocytes and are potential clinical biomarkers of acute myocardial infarction.	hsa_circ_0116795	circ_PPARA	hsa_circ_PPARA	PPARA	acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0116795 (circ_PPARA), derived from PPARA, is up-regulated in the peripheral blood of AMI patients and is induced in human cardiomyocytes under hypoxia. It is mainly cytoplasmic and RNase R-resistant, and shows diagnostic potential for AMI (AUC 0.876)."	0.6142
38478029	Cellular and molecular life sciences : CMLS	2024	CircAKT3 alleviates postoperative cognitive dysfunction by stabilizing the feedback cycle of miR-106a-5p/HDAC4/MEF2C axis in hippocampi of aged mice.	mmu_circ_0008480	circAKT3 / mmu-circAKT3	mmu_circ_AKT3	AKT3	postoperative cognitive dysfunction / POCD	MONDO:0002602	central nervous system disorder	down-regulated	RT-qPCR; RNA-seq	"circAKT3 is down-regulated in hippocampal neurons in POCD mice, and circAKT3 overexpression inhibits neuronal apoptosis and improves postoperative cognitive performance. Mechanistically, circAKT3 binds miR-106a-5p and increases its stability/level, leading to reduced HDAC4 and increased MEF2C, while MEF2C activates miR-106a-5p transcription to form a positive feedback loop."	0.7986
38497483	Journal of the American Heart Association	2024	CircALMS1 Alleviates Pulmonary Microvascular Endothelial Cell Dysfunction in Pulmonary Hypertension.		circALMS1 / circular RNA Alstrom syndrome protein 1	hsa_circ_ALMS1	ALMS1	pulmonary hypertension / PH	MONDO:0005149	pulmonary hypertension	down-regulated	RT-qPCR; RNA-seq	"circALMS1 is down-regulated in hypoxic human PMECs and in plasma from PH patients. Functionally, increasing circALMS1 suppresses PMEC proliferation/migration and promotes apoptosis under hypoxia, and AAV-mediated circALMS1 overexpression alleviates vascular remodeling and improves right ventricular function in rat PH models. Mechanistically, circALMS1 acts as a sponge for miR-17-3p to relieve repression of YTHDF2."	0.8846
38500077	BMC cancer	2024	Hsa_circ_0004872 alleviates meningioma progression by sponging miR-190a-3p/PTEN signaling.	hsa_circ_0004872	circMAPK1 / circ_0004872	hsa_circ_MAPK1	MAPK1	meningioma	MONDO:0016642	meningioma	down-regulated	RT-qPCR	"In meningioma, hsa_circ_0004872 functions as a tumor-suppressive circRNA that inhibits proliferation and promotes apoptosis. Mechanistically, it sponges miR-190a-3p to modulate the PTEN/PI3K/AKT axis, and higher expression is associated with better relapse-free survival."	0.8455
38504194	BMC nephrology	2024	Circular RNA hsa_circ_0005519 contributes to acute kidney injury via sponging microRNA-98-5p.	hsa_circ_0005519	hsa_circSNX13_023	hsa_circ_SNX13	SNX13	acute kidney injury / AKI	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR	"hsa_circ_0005519 is up-regulated in AKI patient serum and in LPS-injured HK-2 cells. Functionally, it promotes LPS-induced tubular cell injury by enhancing inflammation and oxidative stress and reducing cell viability, acting mainly via the hsa_circ_0005519/miR-98-5p/IGF1R axis. Clinically, it shows diagnostic and recovery-prediction potential by ROC analysis."	0.6987
38505381	PeerJ	2023	Circular RNA hsa_circ_0051246 acts as a microRNA-375 sponge to promote the progression of gastric cancer stem cells via YAP1.	hsa_circ_0051246	circ_0051246 / circ0051246			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"In gastric cancer stem cells, circ_0051246 is overexpressed and promotes proliferation/self-renewal, migration and invasion while inhibiting apoptosis. Mechanistically, it sponges miR-375 to increase YAP1 expression (with associated Notch-related protein changes), enhancing tumorigenicity in a cell line-derived orthotopic xenograft model."	0.6978
38506082	Journal of cellular and molecular medicine	2024	CircRNA LOC729852 promotes bladder cancer progression by regulating macrophage polarization and recruitment via the miR-769-5p/IL-10 axis.	hsa_circ_0001676	circLOC729852 / circ LOC729852	hsa_circ_LOC729852		bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"circLOC729852 (hsa_circ_0001676), derived from LOC729852(UMAD1), is upregulated in bladder cancer and promotes tumour cell proliferation, migration and EMT. It sponges miR-769-5p to increase IL-10, suppresses autophagy, and enhances TAM recruitment and M2 polarization via activation of the JAK2/STAT3 pathway, promoting xenograft growth and associating with poor prognosis."	0.8815
38508656	Journal for immunotherapy of cancer	2024	Circular RNA as a source of neoantigens for cancer vaccines.	hsa_circ_0001681	circRAPGEF5 / TC-hsa-RAPGEF5_0098	hsa_circ_RAPGEF5	RAPGEF5	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"circRAPGEF5 is upregulated in CRC and encodes HLA-A*11:01-restricted neoepitopes from circRNA-specific ORFs. These peptides stimulate antigen-specific CD8+ T-cell responses, supporting circRAPGEF5 as a vaccine neoantigen source."	0.721
38508656	Journal for immunotherapy of cancer	2024	Circular RNA as a source of neoantigens for cancer vaccines.		circMYH9 / TC-hsa-MYH9_0092	hsa_circ_MYH9	MYH9	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"circMYH9 is upregulated in CRC tumors and provides translatable neoepitopes (notably MYH9_2) that trigger CD8+ T-cell responses. MYH9_2-trained T cells preferentially kill tumor organoids, and circMYH9 is detectable/enriched in CRC liquid biopsy samples, supporting biomarker-guided vaccination."	0.6716
38509870	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2024	Hypoxic Exosomal circPLEKHM1-Mediated Crosstalk between Tumor Cells and Macrophages Drives Lung Cancer Metastasis.		circPLEKHM1	hsa_circ_PLEKHM1	PLEKHM1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"circPLEKHM1 is a hypoxia-induced circRNA enriched in NSCLC-derived exosomes. It promotes NSCLC metastasis by being transferred to macrophages and acting as a scaffold that enhances PABPC1_eIF4G interaction, boosting OSMR translation and activating OSMR/JAK/STAT3 signaling to drive M2 polarization. High tumor circPLEKHM1 associates with metastasis and poor survival, and circPLEKHM1-ASO treatment reduces metastasis in vivo."	0.8956
38510750	"Cancer drug resistance (Alhambra, Calif.)"	2024	Circular RNA circNCOA3 promotes tumor progression and anti-PD-1 resistance in colorectal cancer.	hsa_circ_0060627	circNCOA3	hsa_circ_NCOA3	NCOA3	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circNCOA3 (has_circ_0060627) is up-regulated in CRC, particularly in anti-PD-1_resistant patients. It promotes proliferation and invasion and drives immune evasion by altering tumor-infiltrating immune cells, reducing sensitivity to PD-1 blockade. Mechanistically, it acts as a ceRNA for miR-203a-3p.1 to increase CXCL1, and high circNCOA3 is associated with poor OS/PFS in PD-1_treated CRC patients."	0.8851
38511058	Non-coding RNA research	2024	Inhibition of breast cancer cell growth and migration through siRNA-mediated modulation of circ_0009910/miR-145-5p/MUC1 axis.	hsa_circ_0009910	circ_0009910 / circ0009910	hsa_circ_MFN2	MFN2	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0009910 is up-regulated in breast cancer tissues and supports oncogenic phenotypes. siRNA knockdown of circ_0009910 in MCF-7 cells reduces proliferation and migration, increases miR-145-5p, and decreases MUC1, supporting a circ_0009910/miR-145-5p/MUC1 regulatory axis. Clinically, higher circ_0009910 is associated with lymph node invasion and shows diagnostic potential by ROC analysis."	0.743
38511064	Non-coding RNA research	2024	CircZCCHC2 (hsa_circ_0000854) promotes hepatocellular carcinoma progression through modulating miR-936/BTBD7 axis and activating Rho/ROCK2 pathway.	hsa_circ_0000854	circZCCHC2	hsa_circ_ZCCHC2	ZCCHC2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circZCCHC2 is up-regulated in HCC tissues and cell lines and its high expression predicts worse overall survival. Functionally, circZCCHC2 promotes proliferation and metastatic behaviors and enhances xenograft tumor growth. Mechanistically, it sponges miR-936 to increase BTBD7 and activate the Rho/ROCK2 pathway (with downstream changes such as ROCK2, MMP-2 and MMP-9)."	0.866
38513259	Aging	2024	Identification and characterization of circular RNAs expression profiles in obstructive sleep apnea-induced liver injury.		mmu_circRNA_000469			obstructive sleep apnea / OSA	MONDO:0007147	obstructive sleep apnea syndrome	up-regulated	RT-qPCR; Microarray	mmu_circRNA_000469 is up-regulated in CIH/OSA-induced liver injury mouse liver tissues and was validated by RT-qPCR. It was included among candidate DECs for predicted circRNA-miRNA-mRNA (ceRNA) network and functional enrichment analyses suggesting involvement in immune-related processes.	0.4997
38513259	Aging	2024	Identification and characterization of circular RNAs expression profiles in obstructive sleep apnea-induced liver injury.		mmu_circRNA_37851			obstructive sleep apnea / OSA	MONDO:0007147	obstructive sleep apnea syndrome	up-regulated	RT-qPCR; Microarray	mmu_circRNA_37851 is a validated differentially expressed circRNA in CIH/OSA-induced liver injury mouse liver tissues (direction reported as up-regulated). No specific miRNA/mRNA axis or pathway was detailed for this circRNA in the paper.	0.4625
38513259	Aging	2024	Identification and characterization of circular RNAs expression profiles in obstructive sleep apnea-induced liver injury.		mmu_circRNA_38959			obstructive sleep apnea / OSA	MONDO:0007147	obstructive sleep apnea syndrome	up-regulated	RT-qPCR; Microarray	"mmu_circRNA_38959 is up-regulated in CIH/OSA-induced liver injury mouse liver tissues and was validated by RT-qPCR. It was further included as one of four circRNAs used to build a predicted circRNA-miRNA-mRNA network, implying a potential ceRNA role."	0.4997
38513259	Aging	2024	Identification and characterization of circular RNAs expression profiles in obstructive sleep apnea-induced liver injury.		mmu_circRNA_38983			obstructive sleep apnea / OSA	MONDO:0007147	obstructive sleep apnea syndrome	up-regulated	RT-qPCR; Microarray	"mmu_circRNA_38983 is up-regulated in CIH/OSA-induced liver injury mouse liver tissues and was validated by RT-qPCR. It was selected among four significant DECs to build a predicted circRNA-miRNA-mRNA network, suggesting potential ceRNA involvement."	0.4997
38513259	Aging	2024	Identification and characterization of circular RNAs expression profiles in obstructive sleep apnea-induced liver injury.		mmu_circRNA_31665			obstructive sleep apnea / OSA	MONDO:0007147	obstructive sleep apnea syndrome	up-regulated	RT-qPCR; Microarray	mmu_circRNA_31665 is a validated differentially expressed circRNA in CIH/OSA-induced liver injury mouse liver tissues (direction reported as up-regulated). The study did not provide a specific downstream miRNA/mRNA mechanism for this circRNA.	0.4625
38513259	Aging	2024	Identification and characterization of circular RNAs expression profiles in obstructive sleep apnea-induced liver injury.		mmu_circRNA_27565 / circRNA_27565	mmu_circ_PICK1	PICK1	obstructive sleep apnea / OSA	MONDO:0007147	obstructive sleep apnea syndrome	down-regulated	RT-qPCR; Microarray	mmu_circRNA_27565 is down-regulated in CIH/OSA-induced liver injury mouse liver tissues and was validated by RT-qPCR. Bioinformatics/network analysis suggested a potential ceRNA interaction involving mmu-miR-1249-5p and the downstream target PICK1.	0.4997
38514579	Discover oncology	2024	Circular RNA circCHSY1 silencing inhibits the malignant progression of esophageal squamous cell carcinoma.	hsa_circ_0005019	circCHSY1 / circ_0005019	hsa_circ_CHSY1	CHSY1	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	circCHSY1 is up-regulated in ESCC tissues/cells and functions as an oncogenic circRNA. Silencing circCHSY1 suppresses malignant phenotypes and xenograft growth by sponging miR-1229-3p to increase TCTN1 expression (circCHSY1/miR-1229-3p/TCTN1 axis).	0.8175
38515149	Molecular cancer	2024	CircHAS2 activates CCNE2 to promote cell proliferation and sensitizes the response of colorectal cancer to anlotinib.	hsa_circ_0005015	circHAS2	hsa_circ_HAS2	HAS2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"CircHAS2 is up-regulated in colorectal cancer and promotes proliferation/cell-cycle progression by sponging miR-1244 to increase CCNE2 and by binding USP10 to disrupt USP10_p53, enhancing p53 nuclear export and degradation (decreasing p21 and further increasing CCNE2). It is downregulated by anlotinib and serves as a predictive biomarker of anlotinib sensitivity in PDO/PDX models and in a phase II cohort."	0.9043
38520084	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2024	Circular RNA Gtdc1 Protects Against Offspring Osteoarthritis Induced by Prenatal Prednisone Exposure by Regulating SRSF1-Fn1 Signaling.		circGtdc1_0001 / circGtdc1	rno_circ_Gtdc1	Gtdc1	osteoarthritis / OA	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR; RNA-seq	"In PPE offspring rats, circGtdc1 is significantly down-regulated in cartilage and its reduction contributes to chondrodysplasia and increased OA susceptibility. Mechanistically, circGtdc1 binds Srsf1 and protects it from BTRC-driven K48-linked polyubiquitination and proteasomal degradation, sustaining EDA/B+Fn1 formation and downstream PI3K/AKT and TGF-beta/SMAD activation to support chondrocyte proliferation and matrix synthesis. Intra-articular AAV-mediated circGtdc1 overexpression ameliorates PPE-induced cartilage defects, and this benefit depends on Srsf1."	0.8486
38520208	Journal of cellular and molecular medicine	2024	Exosomal circSTRBP from cancer cells facilitates gastric cancer progression via regulating miR-1294/miR-593-3p/E2F2 axis.	hsa_circ_0001888	circSTRBP / hsa_circRNA_104907	hsa_circ_STRBP	STRBP	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circSTRBP is up-regulated in gastric cancer tissues/cells and enriched in GC-derived exosomes. It promotes GC proliferation/viability, migration, invasion, angiogenesis and xenograft tumor growth by sponging miR-1294 and miR-593-3p to increase E2F2 expression, and high circSTRBP correlates with poor overall survival."	0.8821
38523597	The Kaohsiung journal of medical sciences	2024	CircITGA7 regulates malignant phenotypes in bladder cancer cells via targeting miR-330-3p/KLF10 axis.		CircITGA7	hsa_circ_ITGA7	ITGA7	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR	"CircITGA7 is downregulated in bladder cancer and functions as a tumor suppressor by sponging miR-330-3p, thereby relieving repression of KLF10. Overexpression of circITGA7 inhibits proliferation, migration, invasion in vitro and suppresses xenograft tumor growth, and higher circITGA7 expression correlates with better overall survival."	0.8174
38524397	International journal of chronic obstructive pulmonary disease	2024	Circular RNA Expression of Peripheral Blood Mononuclear Cells Associated with Risk of Acute Exacerbation in Smoking Chronic Obstructive Pulmonary Disease.	hsa_circ_0042590				chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	down-regulated	RT-qPCR; Microarray	"hsa_circ_0042590 is down-regulated in PBMCs from COPD patients versus controls, and is further decreased in smoking COPD versus non-smoking COPD. Its PBMC level correlates with acute exacerbation frequency in smoking COPD patients and shows diagnostic potential by ROC analysis."	0.5047
38524397	International journal of chronic obstructive pulmonary disease	2024	Circular RNA Expression of Peripheral Blood Mononuclear Cells Associated with Risk of Acute Exacerbation in Smoking Chronic Obstructive Pulmonary Disease.	hsa_circ_0049875				chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR; Microarray	"hsa_circ_0049875 is up-regulated in PBMCs from COPD patients versus controls, and is higher in smoking COPD versus non-smoking COPD. Its PBMC level correlates with acute exacerbation frequency in smoking COPD patients and shows diagnostic potential by ROC analysis."	0.5047
38527916	Renal failure	2024	RfxCas13d-mediated inhibition of Circ1647 alleviates renal fibrosis via PI3K/AKT signaling pathway.		Circ1647	mmu_circ_Sh2d4b	Sh2d4b	chronic kidney disease / CKD	MONDO:0005300	chronic kidney disease	up-regulated	RT-qPCR	"Circ1647 is up-regulated in UUO-induced CKD/renal fibrosis and in TGFbeta1-stimulated renal tubular epithelial cells. Circ1647 promotes ECM marker expression and renal fibrosis, at least partly by activating the PI3K/AKT signaling pathway; RfxCas13d-mediated knockdown alleviates kidney injury and fibrosis."	0.6148
38533181	"Research (Washington, D.C.)"	2024	Silencing circATXN1 in Aging Nucleus Pulposus Cell Alleviates Intervertebral Disc Degeneration via Correcting Progerin Mislocalization.	hsa_circ_0007909	circATXN1	hsa_circ_ATXN1	ATXN1	intervertebral disc degeneration / IDD	MONDO:0011385	intervertebral disk degenerative disorder	up-regulated	RT-qPCR; RNA-seq	"circATXN1 (hsa_circ_0007909) is up-regulated in aging human nucleus pulposus cells/tissues in IVDD and promotes senescence, ECM disruption, and impaired mitochondrial respiration. It is regulated by HNRNPA2B1-associated circularization and binds progerin to drive its nucleus-to-cytoplasm translocation, suppressing IGF-1Rbeta signaling. Silencing circATXN1 via an siRNA-loaded DNA tetrahedron nanogel reverses aging phenotypes in hNPCs and alleviates IVDD in zmpste24_/_ mice."	0.7846
38536591	Discover oncology	2024	Circ_0020460 drives tumorigenesis in cervical cancer through miR-485-3p sponging.	hsa_circ_0020460	circ_0020460 / circDOCK1	hsa_circ_DOCK1	DOCK1	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; RNA-seq	"circ_0020460 is up-regulated in cervical cancer tissues/cells and promotes malignant phenotypes (proliferation, migration, invasion, angiogenesis) while inhibiting apoptosis. Mechanistically, it acts as a ceRNA sponging miR-485-3p, thereby increasing CXCL1 expression and promoting tumor growth in a CaSki xenograft model."	0.8175
38538857	Cellular and molecular life sciences : CMLS	2024	Discovery and verification of mmu_Circ_26986/hsa_Circ_0072463 as a potential biomarker and intervention target for sepsis-associated acute kidney injury.		mmu_Circ_26986 / Circ_26986	mmu_circ_Arl15	Arl15	sepsis-associated acute kidney injury	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR	"mmu_Circ_26986 is induced in LPS-treated renal tubular cells and CLP-induced SA-AKI mouse kidneys. It protects against renal tubular apoptosis and alleviates SA-AKI severity by sponging miRNA-29b-1-5p to increase PAK7 expression (a ceRNA axis), with PAK7 linked to Wnt/beta-catenin signaling."	0.6829
38538857	Cellular and molecular life sciences : CMLS	2024	Discovery and verification of mmu_Circ_26986/hsa_Circ_0072463 as a potential biomarker and intervention target for sepsis-associated acute kidney injury.	hsa_circ_0072463	Circ_0072463			sepsis-associated acute kidney injury / SA-AKI / septic AKI	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR	hsa_Circ_0072463 is induced by LPS in HK-2 cells and is elevated in plasma from SA-AKI patients versus SA-non-AKI and healthy controls. It suppresses HK-2 apoptosis by regulating the miRNA-29b-1-5p/PAK7 axis and shows diagnostic potential for SA-AKI (AUC 0.866) with positive correlation to serum creatinine.	0.6304
38539084	Cellular & molecular biology letters	2024	Oncogenic circ-SLC16A1 promotes progression of non-small cell lung cancer via regulation of the miR-1287-5p/profilin 2 axis.	hsa_circ_0013561	circ-SLC16A1 / circ-solute carrier family 16 member 1	hsa_circ_SLC16A1	SLC16A1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circ-SLC16A1 (hsa_circ_0013561) is up-regulated in NSCLC tissues/cells and mainly localized in the cytoplasm. It promotes NSCLC proliferation, migration, invasion and metastasis while inhibiting apoptosis and facilitating cell-cycle progression. Mechanistically, it functions as a miRNA sponge for miR-1287-5p to increase PFN2 expression, and high circ-SLC16A1 expression is associated with poorer patient survival and more advanced disease features."	0.84
38540291	Biomedicines	2024	Circular RNA CircFOXO3 Functions as a Competitive Endogenous RNA for Acid-Sensing Ion Channel Subunit 1 Mediating Oxeiptosis in Nucleus Pulposus.	hsa_circ_0006404	circFOXO3	hsa_circ_FOXO3	FOXO3	intervertebral disc degeneration / IDD	MONDO:0011385	intervertebral disk degenerative disorder	up-regulated	RT-qPCR; Microarray	"CircFOXO3 is upregulated in degenerative nucleus pulposus tissue and in ROS-stimulated NPCs, and its knockdown suppresses oxeiptosis and alleviates IVDD in vivo. It acts as a ceRNA sponging miR-185-3p and miR-939-5p to increase ASIC1, enhancing ASIC1-mediated Ca2+ influx and activation of the KEAP1_PGAM5_AIFM1 oxeiptosis pathway."	0.8771
38540291	Biomedicines	2024	Circular RNA CircFOXO3 Functions as a Competitive Endogenous RNA for Acid-Sensing Ion Channel Subunit 1 Mediating Oxeiptosis in Nucleus Pulposus.	mmu_circ_0002207	circFOXO3	mmu_circ_FOXO3	FOXO3	intervertebral disc degeneration / IDD	MONDO:0011385	intervertebral disk degenerative disorder	up-regulated	RT-qPCR; Microarray	"CircFOXO3 is upregulated in degenerative nucleus pulposus tissue and in ROS-stimulated NPCs, and its knockdown suppresses oxeiptosis and alleviates IVDD in vivo. It acts as a ceRNA sponging miR-185-3p and miR-939-5p to increase ASIC1, enhancing ASIC1-mediated Ca2+ influx and activation of the KEAP1_PGAM5_AIFM1 oxeiptosis pathway."	0.8771
38553328	International dental journal	2024	Circ_0003764 Regulates the Osteogenic Differentiation of Periodontal Ligament Stem Cells.	hsa_circ_0003764	circ_0003764	hsa_circ_PTPN12		bone regeneration-related diseases	MONDO:0005076	periodontitis	dysregulated	RT-qPCR	"circ_0003764 is decreased during osteogenic induction of PDLSCs but increased under TNF-alpha inflammatory stimulation. Functionally, circ_0003764 suppresses osteogenic differentiation (RUNX2/ALP/OCN, ALP activity, mineralization) and inhibits PDLSC proliferation; knockdown produces the opposite effects."	0.5358
38553795	Thoracic cancer	2024	Circ-POSTN promotes the progression and reduces radiosensitivity in esophageal cancer by regulating the miR-876-5p/FYN axis.	hsa_circ_0030018	circ_POSTN / circRNA periostin	hsa_circ_POSTN	POSTN	esophageal cancer / EC	MONDO:0007576	esophageal cancer	up-regulated	RT-qPCR	"Circ-POSTN is up-regulated in esophageal cancer tissues and cell lines and promotes malignant phenotypes and radioresistance. Mechanistically, it mainly localizes in the cytoplasm and functions as a ceRNA by sponging miR-876-5p to increase FYN, thereby enhancing proliferation/invasion and reducing apoptosis and radiosensitivity; its knockdown suppresses xenograft growth and increases radiosensitivity in vivo."	0.8039
38554157	"Cancer immunology, immunotherapy : CII"	2024	circFTO from M2 macrophage-derived small extracellular vesicles (sEV) enhances NSCLC malignancy by regulation miR-148a-3pPDK4 axis.	hsa_circ_0005941	circFTO	hsa_circ_FTO	FTO	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circFTO is upregulated in NSCLC tissues/cell lines and enriched in M2 macrophage-derived sEV. It promotes NSCLC proliferation, migration/metastasis and aerobic glycolysis by sponging miR-148a-3p to upregulate PDK4, and high circFTO predicts poorer overall survival."	0.8482
38554490	"Clinics (Sao Paulo, Brazil)"	2024	Circ-ABCA1 promotes oxidized low-density lipoprotein-induced inflammation and phenotypic switch in vascular smooth muscle cells.	hsa_circ_0137614	Circ-ABCA1 / circABCA1	hsa_circ_ABCA1	ABCA1	atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"circABCA1 is up-regulated in atherosclerosis (patient sera, ox-LDL-treated VSMCs, and ApoE_/_ mouse aortas) and promotes VSMC proliferation, migration, inflammation, and phenotypic switching. It functions as a ceRNA that sponges miR-885_5p to increase ROCK2, contributing to AS progression and proposed as a potential therapeutic biomarker axis."	0.8298
38556586	Molecular biomedicine	2024	Fat mass and obesity-associated protein (FTO) mediated m6A modification of circFAM192A promoted gastric cancer proliferation by suppressing SLC7A5 decay.	hsa_circ_0006886	circFAM192A	hsa_circ_FAM192A	FAM192A	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"circFAM192A is up-regulated in gastric cancer tissues and promotes GC cell proliferation and xenograft tumor growth. Mechanistically, FTO-mediated m6A demethylation stabilizes circFAM192A by reducing YTHDF2-dependent decay; circFAM192A directly binds SLC7A5 protein to inhibit its degradation, increasing membrane SLC7A5, leucine uptake, and mTOR pathway activation."	0.8855
38560264	Heliyon	2024	Intracellular Staphylococcus aureus infection in human osteoblasts: circRNA expression analysis.	hsa_circ_0085769		hsa_circ_PTK2	PKT-2	intracellular Staphylococcus aureus infection	MONDO:0005545	staphylococcus aureus infection	up-regulated	RNA-seq	hsa_circ_0085769 is reported as up-regulated in S. aureus-infected human osteoblasts by RNA-seq and is predicted to act as a miRNA-binding circRNA. It is positively correlated with PTK2 and is proposed to influence bacterial-invasion-related signaling via miRNAs such as hsa-miR-6886-5p.	0.1768
38560264	Heliyon	2024	Intracellular Staphylococcus aureus infection in human osteoblasts: circRNA expression analysis.	hsa_circ_0002483		hsa_circ_PTK2	PKT-2	intracellular Staphylococcus aureus infection	MONDO:0005545	staphylococcus aureus infection	down-regulated	RNA-seq	"hsa_circ_0002483 is reported as significantly down-regulated in S. aureus-infected human osteoblasts by RNA-seq. It is predicted to bind miRNAs including hsa-miR-6886-5p and is negatively correlated with PTK2, suggesting a potential inhibitory role in bacterial-invasion-related signaling."	0.1768
38561366	Scientific reports	2024	CircGPC3 promotes hepatocellular carcinoma progression and metastasis by sponging miR-578 and regulating RAB7A/PSME3 expression.		circGPC3	hsa_circ_GPC3	GPC3	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circGPC3 is upregulated in hepatocellular carcinoma and promotes proliferation, migration, invasion, EMT-like changes, and metastasis while inhibiting apoptosis. It functions mainly as a ceRNA by sponging miR-578 to increase expression of the downstream targets RAB7A and PSME3, and high circGPC3 expression is associated with worse overall survival."	0.8802
38565536	Signal transduction and targeted therapy	2024	Mex-3 RNA binding family member A (MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy.	hsa_circ_0001686	circ_0001686 / circMPP6	hsa_circ_MPP6	MPP6	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circMPP6 is upregulated in colorectal cancer and predominantly localized in the cytoplasm. It serves as a scaffold to strengthen MEX3A association with PBs components (e.g., MOV10, PABP1, UPF1), promoting PBs aggregation and UPF1-mediated PDE5A mRNA decay, which suppresses autophagy and enhances CRC proliferative/migratory and tumorigenic properties."	0.8439
38566808	Cardiology research and practice	2024	Identification of Plasma Exosomes hsa_circ_0001360 and hsa_circ_0000038 as Key Biomarkers of Coronary Heart Disease.	hsa_circ_0001360				Coronary heart disease / CHD	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR; RNA-seq	"In plasma/blood exosomes from CHD patients, hsa_circ_0001360 is up-regulated and was validated by RT-qPCR. It serves as a diagnostic biomarker with AUC 0.870 and improves performance when combined with hsa_circ_0000038 (AUC 0.940). Its potential downstream miRNA/mRNA targets (e.g., ZEB2) were explored through a circRNA-miRNA-mRNA network analysis."	0.5047
38566808	Cardiology research and practice	2024	Identification of Plasma Exosomes hsa_circ_0001360 and hsa_circ_0000038 as Key Biomarkers of Coronary Heart Disease.	hsa_circ_0000038				Coronary heart disease / CHD	MONDO:0005010	coronary artery disorder	down-regulated	RT-qPCR; RNA-seq	"In plasma/blood exosomes from CHD patients, hsa_circ_0000038 is down-regulated and was validated by RT-qPCR. It serves as a diagnostic biomarker with AUC 0.860 and shows improved diagnostic performance when combined with hsa_circ_0001360 (AUC 0.940). Its downstream miRNA/mRNA targets were explored computationally via a circRNA-miRNA-mRNA network."	0.5047
38568056	Journal of cellular and molecular medicine	2024	CircPVT1 promotes migration and invasion by regulating miR-490-5p/HAVCR2 axis in osteosarcoma cells.	hsa_circ_0001821	circPVT1	hsa_circ_PVT1	PVT1	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circPVT1 is up-regulated in osteosarcoma cell lines and promotes migration and invasion. Mechanistically, it localizes mainly in the cytoplasm and acts as a ceRNA by sponging miR-490-5p, thereby upregulating HAVCR2 to drive these malignant phenotypes."	0.6683
38570856	Biology direct	2024	Circ_0002669 promotes osteosarcoma tumorigenesis through directly binding to MYCBP and sponging miR-889-3p.	hsa_circ_0002669	Circ_0002669	hsa_circ_DOCK1	DOCK1	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; ISH	"circ_0002669 is upregulated in osteosarcoma and is associated with poor overall survival. It promotes OS proliferation, migration/invasion and tumor growth/metastasis by stabilizing MYCBP protein via inhibiting ubiquitin_proteasome degradation and by sponging miR-889-3p to increase MYCBP expression, enhancing c-MYC transcriptional activity."	0.8933
38572093	Acta pharmaceutica Sinica. B	2024	Engagement of N6-methyladenisine methylation of Gng4 mRNA in astrocyte dysfunction regulated by CircHECW2.	mmu_circ_0000041	circHECW2	mmu_circ_HECW2	HECW2	major depressive disorder / MDD	MONDO:0002009	major depressive disorder	up-regulated	RT-qPCR	"circHECW2 is up-regulated in MDD patient plasma and in the CUS mouse model, particularly in astrocytes. It binds WTAP and promotes WTAP ubiquitin-mediated degradation, reducing WTAP-dependent m6A modification of Gng4 mRNA, lowering Gng4 stability/expression, and thereby driving astrocyte dysfunction and depressive-like behaviors."	0.7718
38576737	World journal of clinical cases	2024	Construction of the underlying circRNA-miRNA-mRNA regulatory network and a new diagnostic model in ulcerative colitis by bioinformatics analysis.	hsa_circ_0085323				ulcerative colitis / UC	MONDO:0005101	ulcerative colitis	up-regulated	Microarray	"This study identified hsa_circ_0085323 as an upregulated circRNA in ulcerative colitis and selected it as a diagnostic feature in a nomogram risk model. It was placed upstream of hsa-miR-451 in the predicted ceRNA network, and higher model scores based on this circRNA were associated with increased UC risk."	0.348
38576737	World journal of clinical cases	2024	Construction of the underlying circRNA-miRNA-mRNA regulatory network and a new diagnostic model in ulcerative colitis by bioinformatics analysis.	hsa_circ_0036906				ulcerative colitis / UC	MONDO:0005101	ulcerative colitis	unknown	Microarray	"This study identified hsa_circ_0036906 as a diagnostic feature circRNA for ulcerative colitis in a bioinformatics-derived ceRNA network and a nomogram model. It was predicted to sponge hsa-miR-1249 (with PROK2 appearing as a downstream target gene of miR-1249 in the network), but the authors note the mechanism and expression-direction consistency require experimental verification."	0.348
38577609	Journal of Cancer	2024	"circular RNA circ-231 promotes protein biogenesis of TPI1 and PRDX6 through mediating the interaction of eIF4A3 with STAU1 to facilitate unwinding of secondary structure in 5' UTR, enhancing progression of human esophageal squamous cell carcinoma (ESCC)."		circ-231	hsa_circ_ARHGAP12	ARHGAP12	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"In ESCC, circ-231 is up-regulated and promotes proliferation and migration. Mechanistically, it serves as a scaffold that enhances eIF4A3_STAU1 interaction, enabling unwinding of 5¡ä UTR secondary structures in TPI1/PRDX6 mRNAs and increasing their protein production without changing mRNA levels, and its high expression associates with lymph node metastasis risk."	0.6993
38578882	Cancer biomarkers : section A of Disease markers	2024	Circ_0049271 targets the miR-1197/PTRF axis to attenuate the malignancy of osteosarcoma.	hsa_circ_0049271	circ_0049271 / circ _0049271	hsa_circ_KEAP1	KEAP1	osteosarcoma / OS	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR	circ_0049271 is down-regulated in osteosarcoma tissues and cell lines and mainly localized in the cytoplasm. It suppresses OS cell proliferation and invasion and inhibits xenograft tumor growth by acting as a ceRNA that sponges miR-1197 to restore PTRF expression (circ_0049271/miR-1197/PTRF axis).	0.7795
38579527	Translational oncology	2024	Hsa_circ_0101050 accelerates the progression of Colon cancer by targeting the miR-140-3 p/MELK axis.	hsa_circ_0101050	"circ_0101050 / circ_ 0,101,050"	hsa_circ_UGGT2	UGGT2	colon cancer	MONDO:0021063	malignant colon neoplasm	up-regulated	RT-qPCR	"circ_0101050 is up-regulated in colon cancer tissues and cell lines and promotes malignant phenotypes (proliferation, colony formation, migration) while suppressing apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-140_3p, thereby relieving repression of MELK and enhancing tumor growth in vitro and in a xenograft model."	0.7009
38580662	Nature communications	2024	Statins improve cardiac endothelial function to prevent heart failure with preserved ejection fraction through upregulating circRNA-RBCK1.	hsa_circ_0059151	circRNA-RBCK1 / hsa_circRNA_102979	hsa_circ_RBCK1	RBCK1	heart failure / HF	MONDO:0005252	heart failure	unknown	RT-qPCR; ISH; RNA-seq	"Statins induce AP-2alpha activity to increase circRNA-RBCK1 expression in cardiac endothelial cells. circRNA-RBCK1 binds miR-133a, relieving repression of GTPCH1 and supporting BH4/eNOS coupling, thereby improving endothelial function and preventing diastolic dysfunction in an HFpEF mouse model."	0.7519
38581048	Veterinary research	2024	circRNA_8521 promotes Senecavirus A infection by sponging miRNA-324 to regulate LC3A.		circRNA_8521 / circ_8521	ssc_circ_AGO3	AGO3	Senecavirus A infection / SVA infection / SVA	MONDO:0015197	aneurysm of sinus of Valsalva	up-regulated	RT-qPCR; RNA-seq	"circ_8521 (from the AGO3 locus) is induced by SVA infection and predominantly localizes to the cytoplasm. It promotes SVA infection by acting as a miR-324 sponge, thereby increasing LC3A expression and enhancing autophagy/viral replication-related processes."	0.7211
38581057	Journal of cardiothoracic surgery	2024	Circ_0001786 facilitates gefitinib resistance and malignant progression in non-small cell lung cancer via miR-34b-5p/SRSF1.	hsa_circ_0001786	circ_0001786			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0001786 is up-regulated in gefitinib-resistant NSCLC tissues and cells and promotes gefitinib resistance, colony formation, and reduced apoptosis. Mechanistically, it sponges miR-34b-5p to relieve repression of SRSF1, forming a circ_0001786/miR-34b-5p/SRSF1 axis that drives malignant progression and drug tolerance."	0.6521
38584845	"Open medicine (Warsaw, Poland)"	2024	Circ_0051428 targeting miR-885-3p/MMP2 axis enhances the malignancy of cervical cancer.	hsa_circ_0051428	circ_0051428 / hsa_circ_102566			cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ_0051428 is up-regulated in cervical cancer tissues and cell lines and promotes malignant behaviors (proliferation, invasion) and xenograft tumor growth. Mechanistically, it acts as a miR-885-3p sponge to de-repress the miR-885-3p target MMP2, forming a circ_0051428/miR-885-3p/MMP2 axis."	0.7631
38587436	Translational vision science & technology	2024	Role of Hsa_circ_0000880 in the Regulation of High Glucose-Induced Apoptosis of Retinal Microvascular Endothelial Cells.	hsa_circ_0000880	hsa_circRNA_0000880			diabetic retinopathy / DR	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR; RNA-seq	"In proliferative diabetic retinopathy epiretinal membranes and high-glucose_treated RMECs, hsa_circ_0000880 is upregulated and promotes endothelial dysfunction, including increased ROS and apoptosis. Mechanistically, it localizes mainly in the nucleus and interacts with the protein EIF4A3; silencing hsa_circ_0000880 restores EIF4A3 protein levels and alleviates HG-induced injury phenotypes."	0.6291
38589413	Scientific reports	2024	"CircSNX6 promotes proliferation, metastasis, and angiogenesis in hepatocellular carcinoma via miR-383-5p/VEGFA signaling pathway."	hsa_circ_0031607	circSNX6	hsa_circ_SNX6	SNX6	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circSNX6 is up-regulated in HCC tissues and cell lines and is associated with worse overall survival. Functionally, circSNX6 promotes HCC proliferation, migration/invasion, metastasis and angiogenesis by sponging miR-383-5p to increase VEGFA expression, and its knockdown induces apoptosis and suppresses tumor growth/metastasis in vivo."	0.8616
38591009	iScience	2024	CircTMEM165 facilitates endothelial repair by modulating mitochondrial fission via miR-192/SCP2 in vitro and in vivo.		CircTMEM165	hsa_circ_TMEM165	TMEM165	in-stent restenosis / ISR	MONDO:0005010	coronary artery disorder	down-regulated	RT-qPCR; ISH	"CircTMEM165 is down-regulated in ISR patient serum and vascular tissues and is decreased after carotid balloon injury. It protects endothelial cells by inhibiting LPS-induced inflammation/adhesion and reducing apoptosis and mitochondrial fission, acting mainly through a ceRNA mechanism by sponging miR-192-3p to increase SCP2 and suppress NF-kappaB signaling and DRP1-associated fission."	0.8479
38603733	PloS one	2024	Construction and analysis of competitive endogenous RNA networks and prognostic models associated with ovarian cancer based on the exoRBase database.	hsa_circ_0000437				ovarian cancer / OC	MONDO:0008170	ovarian cancer	dysregulated	RNA-seq	"hsa_circ_0000437 was identified as a hub circRNA in a blood-exosome ceRNA network for ovarian cancer based on exoRBase sequencing data and in-silico miRNA binding predictions; its expression was differentially expressed in OC vs controls, but no experimental functional validation was provided."	0.1768
38603733	PloS one	2024	Construction and analysis of competitive endogenous RNA networks and prognostic models associated with ovarian cancer based on the exoRBase database.	hsa_circ_0001472				ovarian cancer / OC	MONDO:0008170	ovarian cancer	dysregulated	RNA-seq	"hsa_circ_0001472 was identified bioinformatically as a hub circRNA in an exosomal ceRNA network for ovarian cancer; it was differentially expressed in OC vs normal controls, with only sequencing and computational prediction support."	0.1768
38603733	PloS one	2024	Construction and analysis of competitive endogenous RNA networks and prognostic models associated with ovarian cancer based on the exoRBase database.	hsa_circ_0005455				ovarian cancer / OC	MONDO:0008170	ovarian cancer	dysregulated	RNA-seq	hsa_circ_0005455 was highlighted as a hub circRNA within an exosomal ceRNA network constructed for ovarian cancer using exoRBase sequencing data and computational miRNA-binding predictions; no direct downstream miRNAs/mRNAs or wet-lab validation were reported for this circRNA.	0.1768
38610009	European journal of medical research	2024	Circ-10720 as a ceRNA adsorbs microRNA-1238 and modulates ZEB2 to boost NSCLC development by activating EMT.	hsa_circ_0018189	circ-10720	hsa_circ_CUL	CUL	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ-10720 is up-regulated in NSCLC tissues/cells and promotes malignant phenotypes (proliferation, migration/invasion and EMT) while reducing apoptosis. Mechanistically, it functions as a ceRNA that sponges miR-1238, thereby increasing ZEB2 expression and enhancing EMT; circ-10720 knockdown suppresses xenograft tumor growth."	0.8322
38613636	Journal of bioenergetics and biomembranes	2024	CircDiaph3 aggravates H/R-induced cardiomyocyte apoptosis and inflammation through miR-338-3p/SRSF1 axis.		circDiaph3			acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR; RNA-seq	"circDiaph3 is up-regulated in AMI and in H/R-treated cardiomyocytes and exacerbates cardiomyocyte apoptosis, inflammatory cytokine release, and ROS. Mechanistically it acts in the cytoplasm as a miR-338-3p sponge to increase SRSF1, forming a circDiaph3/miR-338-3p/SRSF1 axis."	0.742
38613636	Journal of bioenergetics and biomembranes	2024	CircDiaph3 aggravates H/R-induced cardiomyocyte apoptosis and inflammation through miR-338-3p/SRSF1 axis.		circDiaph3			acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR; RNA-seq	"circDiaph3 is up-regulated in AMI and in H/R-treated cardiomyocytes and exacerbates cardiomyocyte apoptosis, inflammatory cytokine release, and ROS. Mechanistically it acts in the cytoplasm as a miR-338-3p sponge to increase SRSF1, forming a circDiaph3/miR-338-3p/SRSF1 axis."	0.742
38613636	Journal of bioenergetics and biomembranes	2024	CircDiaph3 aggravates H/R-induced cardiomyocyte apoptosis and inflammation through miR-338-3p/SRSF1 axis.		circDiaph3			acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR; RNA-seq	"circDiaph3 is up-regulated in AMI and in H/R-treated cardiomyocytes and exacerbates cardiomyocyte apoptosis, inflammatory cytokine release, and ROS. Mechanistically it acts in the cytoplasm as a miR-338-3p sponge to increase SRSF1, forming a circDiaph3/miR-338-3p/SRSF1 axis."	0.742
38617055	International journal of general medicine	2024	The Combination of circEPSTI1 and MIF Offers Diagnostic Value for Endometrial Cancer.		circEPSTI1	hsa_circ_EPSTI1	EPSTI1	endometrial cancer / EC	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR	"circEPSTI1 is up-regulated in the serum/plasma of endometrial cancer patients and can discriminate EC from healthy controls by ROC analysis. High serum circEPSTI1 correlates with more aggressive clinicopathological features and predicts worse PFS/OS, supporting its use as a circulating diagnostic/prognostic biomarker (especially combined with MIF)."	0.5918
38617926	Heliyon	2024	CircRNA circRREB1 promotes tumorigenesis and progression of breast cancer by activating Erk1/2 signaling through interacting with GNB4.	hsa_circ_0001573	circRREB1	hsa_circ_RREB1	RREB1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; ISH; Microarray	"circRREB1 (hsa_circ_0001573), derived from RREB1, is up-regulated in breast cancer and predicts worse survival. Functionally, it promotes proliferation, migration/invasion, tumor growth and metastasis and suppresses apoptosis. Mechanistically, circRREB1 directly binds GNB4 and activates ERK1/2 signaling (increased p-Erk1/2 and c-Myc)."	0.8846
38619648	Discover oncology	2024	Circular RNA COL1A1 promotes Warburg effect and tumor growth in nasopharyngeal carcinoma.	hsa_circ_0044569	circCOL1A1	hsa_circ_COL1A1	COL1A1	nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"circCOL1A1 (hsa_circ_0044569) is up-regulated in nasopharyngeal carcinoma tissues and NPC cell lines and is mainly localized in the cytoplasm. It promotes proliferation, migration, invasion and glycolysis/Warburg-effect phenotypes and inhibits apoptosis by sponging miR-370-5p to modulate PTMA in a circCOL1A1/miR-370-5p/PTMA axis. High circCOL1A1 expression correlates with lymph node metastasis and advanced TNM stage."	0.8275
38622592	Cardiovascular diabetology	2024	Circ_005077 accelerates myocardial lipotoxicity induced by high-fat diet via CyPA/p47PHOX mediated ferroptosis.		circ_005077 / rno-circ_005077	rno_circ_Crmp1		myocardial lipotoxicity	MONDO:0004994	cardiomyopathy	up-regulated	RT-qPCR; ISH; Microarray	"circ_005077 is up-regulated in HFD rat myocardium and promotes palmitate/HFD-induced myocardial lipotoxicity. It binds CyPA to reduce CyPA ubiquitination and degradation, strengthens CyPA_p47phox interaction, elevates NADPH oxidase-driven ROS, and thereby promotes ferroptosis, hypertrophy, fibrosis, and cardiac dysfunction."	0.8816
38622668	Journal of orthopaedic surgery and research	2024	Circ_0044235 regulates the development of osteoarthritis by the modulation of miR-375/PIK3R3 axis.	hsa_circ_0044235	circ_0044235	hsa_circ_CDC27	CDC27	osteoarthritis / OA	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR	"circ_0044235 is down-regulated in osteoarthritis cartilage and in IL-1beta-treated CHON-001 chondrocytes. Functionally, circ_0044235 overexpression protects chondrocytes by increasing viability and reducing apoptosis, inflammatory cytokine production, and ECM degradation. Mechanistically, it sponges miR-375 to relieve repression of PIK3R3, forming a circ_0044235/miR-375/PIK3R3 ceRNA axis."	0.8107
38626179	PloS one	2024	CircPRMT5 promotes progression of osteosarcoma by recruiting CNBP to regulate the translation and stability of CDK6 mRNA.		CircPRMT5	hsa_circ_PRMT5	PRMT5	osteosarcoma	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circPRMT5 is up-regulated in osteosarcoma cell lines and mainly localized in the cytoplasm. It promotes proliferation, migration and invasion and inhibits apoptosis by recruiting the RBP CNBP to enhance CDK6 mRNA stability and translation, thereby increasing CDK6 and malignant activity."	0.8
38627689	BMC urology	2024	Diagnostic value of urine cyclic RNA-0071196 for bladder urothelial carcinoma.		circRNA-0071196 / cyclic RNA-0071196			bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"Urinary circRNA-0071196 is up-regulated in BUC patients and can distinguish BUC from non-BUC controls with high diagnostic performance (AUC 0.935). Prior results cited by the authors suggest a ceRNA mechanism where circRNA-0071196 sponges miRNA-19b-3p to increase CIT, promoting malignant phenotypes such as proliferation and migration."	0.5261
38630149	Cell biology and toxicology	2024	circRNA-PTPN4 mediated regulation of FOXO3 and ZO-1 expression: implications for blood-brain barrier integrity and cognitive function in uremic encephalopathy.		circRNA-PTPN4	mmu_circ_PTPN4	PTPN4	Uremic encephalopathy / UE	MONDO:0005300	chronic kidney disease	down-regulated	RT-qPCR; RNA-seq	"circRNA-PTPN4 is down-regulated in UE mouse brain and acts protectively by sponging miR-301a-3p to de-repress FOXO3. FOXO3 then promotes ZO-1 transcription, strengthening endothelial tight junctions, improving BBB integrity and cognitive performance in UE models."	0.8279
38632984	iScience	2024	circKDM1A suppresses bladder cancer progression by sponging miR-889-3p/CPEB3 and stabilizing p53 mRNA.	hsa_circ_0009061	circKDM1A	hsa_circ_KDM1A	KDM1A	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; Microarray	"circKDM1A (hsa_circ_0009061) is down-regulated in bladder cancer and acts as a tumor suppressor by inhibiting proliferation and tumor growth while promoting apoptosis. Mechanistically, it sponges miR-889-3p to relieve repression of CPEB3, and CPEB3 stabilizes p53 mRNA via binding the CPE signal in p53 3¡äUTR."	0.8574
38634567	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2024	Tau Aggregation-Dependent Lipid Peroxide Accumulation Driven by the hsa_circ_0001546/14-3-3/CAMK2D/Tau Complex Inhibits Epithelial Ovarian Cancer Peritoneal Metastasis.	hsa_circ_0001546	circ_0001546	hsa_circ_FAM114A2	FAM114A2	epithelial ovarian cancer / EOC	MONDO:0005140	ovarian carcinoma	down-regulated	RT-qPCR; ISH; RNA-seq	"hsa_circ_0001546 is down-regulated in epithelial ovarian cancer and functions as a tumor suppressor. It binds 14-3-3 proteins as a chaperone/scaffold to recruit CAMK2D, promoting Tau Ser324 phosphorylation and Tau aggregation, which increases lipid peroxides and induces LPO-dependent ferroptosis, thereby inhibiting EOC peritoneal metastasis. High hsa_circ_0001546 expression is associated with better OS and DFS."	0.8826
38635539	PloS one	2024	Bioinformatics analysis of the potentially functional circRNA-miRNA-mRNA network in breast cancer.	hsa_circ_0000515	hsa_circRNA_000585	hsa_circ_RPPH1	RPPH1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	Microarray	"This study predicts that hsa_circ_0000515 (alias hsa_circRNA_000585) is up-regulated in breast cancer and may act as a miR-486-5p sponge. The proposed ceRNA axis hsa_circ_0000515/miR-486-5p/SDC1 is suggested as a biomarker candidate, particularly for basal-like breast cancer classification."	0.1768
38635539	PloS one	2024	Bioinformatics analysis of the potentially functional circRNA-miRNA-mRNA network in breast cancer.	hsa_circ_0016201	hsa_circRNA_100435	hsa_circ_DSTYK	DSTYK	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	Microarray	"This study predicts that hsa_circ_0016201 (alias hsa_circRNA_100435) is down-regulated in breast cancer and may sponge miR-141-5p. It is included in a predicted circRNA_miRNA_mRNA network/modules and is suggested for further functional investigation, especially in the basal-like context."	0.1768
38635539	PloS one	2024	Bioinformatics analysis of the potentially functional circRNA-miRNA-mRNA network in breast cancer.	hsa_circ_0000375	hsa_circRNA_101004	hsa_circ_IFFO1	IFFO1	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	Microarray	"This study predicts that hsa_circ_0000375 (alias hsa_circRNA_101004) is down-regulated in breast cancer and may sponge miR-183-5p. It participates in predicted circRNA_miRNA_mRNA regulatory modules (e.g., involving hub genes such as FGF2, EGR1, TNXB) and is suggested for further cellular functional investigation."	0.1768
38635778	PloS one	2024	circTADA2A inhibited SLC38A1 expression and suppresses melanoma progression through the prevention of CNBP trans-activation.	hsa_circ_0043278	circTADA2A	hsa_circ_TADA2A	TADA2A	melanoma	MONDO:0005105	melanoma	down-regulated	RT-qPCR	"circTADA2A (hsa_circ_0043278) is down-regulated in melanoma cell lines and mainly localized in the nucleus. It suppresses melanoma cell proliferation, migration, invasion and G1/S transition by binding CNBP and preventing CNBP-mediated transactivation of SLC38A1, thereby reducing SLC38A1 transcription."	0.8165
38638101	Gut and liver	2024	The Circular RNA Circ_0043947 Promoted Gastric Cancer Progression by Sponging miR-384 to Regulate CREB1 Expression.	hsa_circ_0043947	circ_0043947	hsa_circ_BRCA1	BRCA1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"Circ_0043947 is up-regulated in gastric cancer tissues and cells and functions as an oncogenic circRNA. It sponges miR-384 to increase CREB1 expression, thereby promoting proliferation, migration/invasion, cell-cycle progression and tumor growth while suppressing apoptosis; high expression is associated with worse overall survival."	0.8593
38638425	Frontiers in immunology	2024	Altered circular RNA expressions in extracellular vesicles from bronchoalveolar lavage fluids in mice after bacterial infections.		circRNA 30884 / circ30884	mmu_circ_XDH	XDH	bacterial pneumonia	MONDO:0004652	bacterial pneumonia	dysregulated	RT-qPCR; Microarray	circ30884 (host gene XDH) is detectable in BALF extracellular vesicles from mice after noxious lung stimuli and shows altered expression relative to controls based on microarray screening with RT-qPCR confirmation. The study also uses this circRNA as an example to demonstrate BSJ-targeting primers that do not detect the linear host RNA.	0.5922
38638425	Frontiers in immunology	2024	Altered circular RNA expressions in extracellular vesicles from bronchoalveolar lavage fluids in mice after bacterial infections.		circRNA 25900 / circ25900			bacterial pneumonia	MONDO:0004652	bacterial pneumonia	up-regulated	RT-qPCR; Microarray	"circ25900 is detectable in BALF extracellular vesicles and shows LPS-induced upregulation at early time points, with attenuation after prolonged LPS exposure. The study further predicts miRNAs that may interact with this circRNA, but does not experimentally validate the miRNA interactions."	0.5922
38638425	Frontiers in immunology	2024	Altered circular RNA expressions in extracellular vesicles from bronchoalveolar lavage fluids in mice after bacterial infections.		circ006620 / circ06620			bacterial pneumonia	MONDO:0004652	bacterial pneumonia	dysregulated	RT-qPCR; Microarray	"circ006620 shows differential expression across lung cell types (alveolar macrophages vs neutrophils) and is inducible/differentially expressed after LPS in lung tissue/epithelial cells (supplementary data). It was not detectable in BALF EVs by RT-qPCR despite microarray selection, lowering confidence for EV-level conclusions."	0.4851
38639887	Basic research in cardiology	2024	Circular RNA circZFPM2 regulates cardiomyocyte hypertrophy and survival.	hsa_circ_0003380	circZFPM2 / mmu_circ_0000597	hsa_circ_ZFPM2	ZFPM2	Hypertrophic cardiomyopathy / HCM	MONDO:0005045	hypertrophic cardiomyopathy	up-regulated	RT-qPCR; RNA-seq	"circZFPM2 (hsa_circ_0003380) is up-regulated in hypertrophic cardiomyopathy heart tissue and HCM patient-derived cardiomyocytes. Loss of circZFPM2 aggravates hypertrophy, mitochondrial dysfunction, ROS, and apoptosis, while circZFPM2 overexpression/IVT delivery is cardioprotective and improves organoid contractile parameters, potentially via protein interactions and regulation of mitochondrial/contractile gene programs."	0.7394
38640297	Medicine	2024	Comprehensive analysis of circRNA expression profiles in postmenopausal women differing in bone mineral density.	hsa_circ_0060849				postmenopausal osteoporosis / PMOP	MONDO:0008159	postmenopausal osteoporosis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0060849 is up-regulated progressively from normal BMD to osteopenia to osteoporosis in postmenopausal women. The study predicts it may act as a miRNA sponge (e.g., hsa-miR-296-5p/miR-370/miR-635) to affect osteoporosis-related target genes, and it is proposed as a potential early PMOP biomarker/therapeutic target."	0.4032
38640297	Medicine	2024	Comprehensive analysis of circRNA expression profiles in postmenopausal women differing in bone mineral density.	hsa_circ_0001394				postmenopausal osteoporosis / PMOP	MONDO:0008159	postmenopausal osteoporosis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001394 is progressively up-regulated from normal BMD to osteopenia to osteoporosis in postmenopausal women. The study predicts it may function in a circRNA_miRNA_mRNA network (e.g., involving hsa-miR-296-5p/miR-370/miR-635) affecting osteoporosis-related genes, and proposes it as a potential early PMOP biomarker/therapeutic target."	0.4032
38641828	Journal of experimental & clinical cancer research : CR	2024	N6-methyladenosine-modified circSLCO1B3 promotes intrahepatic cholangiocarcinoma progression via regulating HOXC8 and PD-L1.		circSLCO1B3	hsa_circ_SLCO1B3	SLCO1B3	intrahepatic cholangiocarcinoma / ICC	MONDO:0003210	intrahepatic cholangiocarcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circSLCO1B3 is up-regulated in intrahepatic cholangiocarcinoma and promotes tumor growth, EMT, invasion/metastasis and immune evasion. It sponges miR-502-5p to increase HOXC8 and activate SMAD3-driven TGF-beta/SMAD signaling, and it also increases PD-L1 protein by inhibiting SPOP-associated ubiquitination/proteasomal degradation; METTL3/YTHDC1-dependent m6A modification stabilizes circSLCO1B3."	0.9034
38642144	Journal of cancer research and clinical oncology	2024	Circ_0087851 suppresses colorectal cancer malignant progression through triggering miR-593-3p/BAP1-mediated ferroptosis.	hsa_circ_0087851	circ_0087851	hsa_circ_RAD23B	RAD23B	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"circ_0087851 is down-regulated in colorectal cancer and acts as a tumor suppressor. Its overexpression inhibits proliferation, migration and invasion and promotes ferroptosis by sponging miR-593-3p to de-repress BAP1, also reducing tumor growth in xenograft models."	0.8121
38644890	Heliyon	2024	Deciphering the role of non-coding RNAs involved in sorafenib resistance.	hsa_circ_0001944	circ_0001944			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RNA-seq	circ_0001944 was identified by whole transcriptome sequencing as an upregulated circRNA in both sorafenib-resistant SMMC7721/S and Huh7/S hepatocellular carcinoma cell lines compared with parental cells. No specific miRNA/mRNA interaction axis or functional mechanism was experimentally established for circ_0001944 in this study.	0.1768
38644890	Heliyon	2024	Deciphering the role of non-coding RNAs involved in sorafenib resistance.	hsa_circ_0002874	circ_0002874			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RNA-seq	circ_0002874 is downregulated in sorafenib-resistant HCC cells and is placed in a ceRNA network where it targets miR-27a-5p to affect downstream mRNAs. Network-level enrichment links this axis to Hippo signaling activation and to processes related to metabolic reprogramming and EMT that may contribute to sorafenib resistance.	0.1768
38644890	Heliyon	2024	Deciphering the role of non-coding RNAs involved in sorafenib resistance.	hsa_circ_0078607	circ_0078607			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RNA-seq	"circ_0078607 is upregulated in sorafenib-resistant HCC cells and is proposed (via a ceRNA network) to target miR-320b, affecting downstream mRNAs including CDC42EP5, FABP3, NSMF, ADAMTS10, GRB10, F12, IA2, and MIA2. Enrichment analysis connects this network to vesicle-mediated transport and TGF-beta signaling, suggesting a role in metabolic reprogramming-related sorafenib resistance."	0.1768
38649401	Scientific reports	2024	Exploration of lncRNA/circRNA-miRNA-mRNA network in patients with chronic atrophic gastritis in Tibetan plateau areas based on DNBSEQ-G99 RNA sequencing.	hsa_circ_0082984				chronic atrophic gastritis / CAG	MONDO:0006665	chronic atrophic gastritis	dysregulated	RNA-seq	"hsa_circ_0082984 was identified as a differentially expressed circRNA between CAG and CNAG in Tibetan plateau patients and was incorporated into circRNA-miRNA-mRNA ceRNA pairs (hsa-miR-204-5p-CACNG8 and hsa-miR-873-3p-TMC5), suggesting a potential role in CAG pathogenesis."	0.1768
38649401	Scientific reports	2024	Exploration of lncRNA/circRNA-miRNA-mRNA network in patients with chronic atrophic gastritis in Tibetan plateau areas based on DNBSEQ-G99 RNA sequencing.	hsa_circ_0008561	hsa_circ_0008561			chronic atrophic gastritis / CAG	MONDO:0006665	chronic atrophic gastritis	dysregulated	RNA-seq	"hsa_circ_0008561 (also written as has_circ_0008561) was identified as differentially expressed between CAG and CNAG and appeared in multiple circRNA-miRNA-mRNA relationship pairs (with hsa-miR-34a-5p, hsa-miR-3614-5p, and hsa-miR-129), suggesting potential involvement in CAG pathogenesis through ceRNA regulation."	0.1768
38649946	Journal of orthopaedic surgery and research	2024	CircPRKD3/miR-6783-3p responds to mechanical force to facilitate the osteogenesis of stretched periodontal ligament stem cells.	hsa_circ_0000992	circPRKD3 / circular RNA protein kinase D3	hsa_circ_PRKD3	PRKD3	periodontal tissue remodeling process	MONDO:0002081	musculoskeletal system disorder	up-regulated	RT-qPCR	"circPRKD3 is up-regulated by mechanical stretch in PDLSCs and promotes early osteogenic differentiation. Mechanistically, it localizes to both nucleus and cytoplasm (with higher cytoplasmic proportion) and forms a sponge interaction with hsa-miR-6783-3p, indirectly affecting RUNX2-related osteogenesis during periodontal tissue remodeling under orthodontic mechanical force."	0.6229
38654205	BMC cancer	2024	CircPHGDH downregulation decreases papillary thyroid cancer progression through miR-122-5p/PKM2 axis.	hsa_circ_0013768	circPHGDH / circRNA phosphoglycerate dehydrogenase	hsa_circ_PHGDH	PHGDH	papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circPHGDH is up-regulated in papillary thyroid carcinoma tissues and cell lines and mainly localizes to the cytoplasm. Silencing circPHGDH suppresses proliferation, migration, tumor growth and lung metastasis, and reduces glycolysis by acting as a ceRNA for miR-122-5p to regulate PKM2."	0.697
38654320	Journal of experimental & clinical cancer research : CR	2024	CircCDYL2 bolsters radiotherapy resistance in nasopharyngeal carcinoma by promoting RAD51 translation initiation for enhanced homologous recombination repair.		circCDYL2	hsa_circ_CDYl2	CDYL2	nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circCDYL2 is up-regulated in nasopharyngeal carcinoma and correlates with poor overall survival and radiotherapy resistance. Mechanistically, it acts as a scaffold binding EIF3D and RAD51 mRNA to promote RAD51 translation initiation, enhancing homologous recombination repair and radioresistance."	0.89
38658867	BMC pregnancy and childbirth	2024	The application of plasma circRAD18 in the prediction of gestational diabetes mellitus (GDM) and its adverse effects.		circRAD18	hsa_circ_RAD18	RAD18	gestational diabetes mellitus / GDM	MONDO:0005406	gestational diabetes	down-regulated	RT-qPCR	Plasma circRAD18 levels are decreased at pregnancy confirmation in women who later develop GDM. Low plasma circRAD18 serves as a potential early biomarker predicting GDM risk and is associated with subsequent hypertension.	0.4758
38658954	Journal of experimental & clinical cancer research : CR	2024	CircPDE5A-encoded novel regulator of the PI3K/AKT pathway inhibits esophageal squamous cell carcinoma progression by promoting USP14-mediated de-ubiquitination of PIK3IP1.	hsa_circ_0070805	circPDE5A	hsa_circ_PDE5A	PDE5A	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	RT-qPCR; ISH; Microarray	"circPDE5A is down-regulated in ESCC and acts as a tumor suppressor by inhibiting proliferation, metastasis and EMT. It functions mainly by encoding the peptide PDE5A-500aa, which stabilizes PIK3IP1 via USP14-mediated de-ubiquitination (K48 chain, K198) and thereby suppresses PI3K/AKT signaling. Low circPDE5A is associated with advanced stage and worse prognosis in ESCC patients."	0.8414
38659023	European journal of medical research	2024	Competitive adsorption of microRNA-532-3p by circular RNA SOD2 activates Thioredoxin Interacting Protein/NLR family pyrin domain containing 3 pathway and promotes pyroptosis of non-alcoholic fatty hepatocytes.	hsa_circ_0004662	circSOD2 / circular RNA SOD2	hsa_circ_SOD2	SOD2	non-alcoholic fatty liver disease / NAFLD	MONDO:0013209	metabolic dysfunction-associated steatotic liver disease	up-regulated	RT-qPCR; Northern Blot	"circSOD2 is upregulated in NAFLD and mainly localized in the cytoplasm. It functions as a ceRNA to sponge miR-532-3p, thereby de-repressing TXNIP and activating the TXNIP/NLRP3 inflammasome cascade, which promotes inflammatory pyroptosis in hepatocytes and worsens NAFLD phenotypes in vivo."	0.8661
38659042	Journal of orthopaedic surgery and research	2024	Upregulation of circ_0076684 in osteosarcoma facilitates malignant processes by mediating miRNAs/CUX1.	hsa_circ_0076684	circ_0076684	hsa_circ_RUNX2	RUNX2	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ_0076684 is up-regulated in osteosarcoma and promotes malignant phenotypes (proliferation, migration, invasion, and xenograft tumor growth). Mechanistically, it functions as a cytoplasmic ceRNA that sponges miR-370-3p/miR-140-3p/miR-193a-5p to increase CUX1 expression, and its high expression is associated with worse clinical features and prognosis."	0.7592
38659042	Journal of orthopaedic surgery and research	2024	Upregulation of circ_0076684 in osteosarcoma facilitates malignant processes by mediating miRNAs/CUX1.	hsa_circ_0003563	circ_0003563	hsa_circ_RUNX2	RUNX2	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ_0003563 is up-regulated in osteosarcoma samples and cell lines, likely linked to CBX4-mediated transcriptional activation at the RUNX2 locus. The study did not find significant associations with clinical features/prognosis and did not establish a specific functional mechanism for circ_0003563 in OS."	0.2995
38659042	Journal of orthopaedic surgery and research	2024	Upregulation of circ_0076684 in osteosarcoma facilitates malignant processes by mediating miRNAs/CUX1.	hsa_circ_0076691	circ_0076691	hsa_circ_RUNX2	RUNX2	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ_0076691 is up-regulated in osteosarcoma samples and cell lines, likely linked to CBX4-mediated transcriptional activation at the RUNX2 locus. The study did not find significant associations with clinical features/prognosis and did not establish a specific functional mechanism for circ_0076691 in OS."	0.2995
38659080	Clinical and translational medicine	2024	N6-methyladenosine-modified circTEAD1 stabilizes Yap1 mRNA to promote chordoma tumorigenesis.		hsa-circ_TEAD1_0016 / circTEAD1	hsa_circ_TEAD1	TEAD1	chordoma	MONDO:0008978	chordoma	up-regulated	RT-qPCR; RNA-seq	"circTEAD1 is up-regulated in chordoma and promotes proliferation, migration, invasion, and in vivo tumorigenesis. Mechanistically, METTL3-dependent m6A modification facilitates circTEAD1 cytoplasmic export, where circTEAD1 binds IGF2BP3 and Yap1 mRNA to form a ternary complex that stabilizes Yap1 mRNA and activates Hippo/YAP signaling output. High circTEAD1 expression is associated with worse CDFS."	0.8776
38660591	Non-coding RNA research	2024	CircANXA4 (hsa_circ_0055087) regulates the miR-1256/PRM1 axis to promote tumor progression in colorectal cancer.	hsa_circ_0055087	CircANXA4	hsa_circ_ANXA4	ANXA4	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"CircANXA4 is up-regulated in colorectal cancer tissues and cell lines and is associated with advanced stage, distant metastasis, and worse survival. Functionally, circANXA4 promotes CRC cell proliferation and invasion by acting as a ceRNA that sponges miR-1256, thereby increasing PRM1 expression."	0.848
38662258	Journal of cancer research and clinical oncology	2024	"CircCOL1A1 promotes proliferation, migration, and invasion of colorectal cancer (CRC) cells and glutamine metabolism through GLS1 up-regulation by sponging miR-214-3p."	hsa_circ_0044556	circCOL1A1	hsa_circ_COL1A1	COL1A1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circCOL1A1 is up-regulated in CRC tissues and cell lines and promotes CRC cell proliferation, migration, invasion, EMT-like changes, tumorigenesis, and glutamine metabolism. Mechanistically, it mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-214-3p, thereby increasing GLS1 and enhancing glutaminolysis. High circCOL1A1 expression is associated with advanced clinicopathologic features and poor overall survival."	0.8226
38665782	Turkish journal of biology = Turk biyoloji dergisi	2024	CircRNA LDLR promotes proliferation and aerobic glycolysis of gastric cancer cells by targeting CHD1 with miR-449b-5p.	hsa_circ_0006877	circRNA LDLR / circLDLR	hsa_circ_LDLR	LDLR	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circLDLR (hsa_circ_0006877), derived from LDLR, is up-regulated in gastric cancer tissues and GC cell lines and is mainly localized in the cytoplasm. It promotes GC cell proliferation and aerobic glycolysis and inhibits apoptosis by sponging miR-449b-5p to derepress CHD1, and circLDLR knockdown suppresses xenograft tumor growth."	0.8439
38673933	International journal of molecular sciences	2024	Whole-Transcriptome Sequencing of Knee Joint Cartilage from Kashin-Beck Disease and Osteoarthritis Patients.	hsa_circ_0069064				osteoarthritis / OA	MONDO:0005178	osteoarthritis	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0069064 is differentially expressed between KBD and OA in human knee cartilage and was experimentally validated by qRT-PCR in chondrocytes, consistent with the sequencing results."	0.3588
38673933	International journal of molecular sciences	2024	Whole-Transcriptome Sequencing of Knee Joint Cartilage from Kashin-Beck Disease and Osteoarthritis Patients.		circRNA12218			osteoarthritis / OA	MONDO:0005178	osteoarthritis	unknown	RNA-seq	"circRNA12218 is a differentially expressed circRNA between KBD and OA cartilage and is predicted (via ceRNA network analysis) to bind three miRNAs that target ACAN, suggesting a potential role in cartilage matrix regulation."	0.1768
38673933	International journal of molecular sciences	2024	Whole-Transcriptome Sequencing of Knee Joint Cartilage from Kashin-Beck Disease and Osteoarthritis Patients.		circRNA12487			osteoarthritis / OA	MONDO:0005178	osteoarthritis	unknown	RNA-seq	"circRNA12487 is a differentially expressed circRNA between KBD and OA cartilage and is predicted to bind seven miRNAs that target COL2A1, implicating it in regulation of cartilage extracellular matrix components."	0.1768
38678242	Cancer cell international	2024	circ-TFRC downregulation suppresses ovarian cancer progression via miR-615-3p/IGF2 axis regulation.	hsa_circ_0068631	circ-TFRC	hsa_circ_TFRC	TFRC	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; ISH	"circ-TFRC (hsa_circ_0068631) is up-regulated in ovarian cancer tissues/cells and mainly localized in the cytoplasm. Silencing circ-TFRC suppresses OC proliferation, migration/invasion, tumor growth and lung metastasis by acting as a ceRNA to sponge miR-615-3p and thereby increase IGF2 expression."	0.7369
38680002	Asian Pacific journal of cancer prevention : APJCP	2024	Evaluation of Circular RNA SMARCA5 as a Novel Biomarker for Hepatocellular Carcinoma.		CircSMARCA5 / circular RNA SMARCA5	hsa_circ_SMARCA5	SMARCA5	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	CircSMARCA5 is significantly down-regulated in plasma from HCC patients compared with HCV cirrhotic patients and controls. Plasma CircSMARCA5 shows strong diagnostic performance for early HCC and may outperform AFP in sensitivity.	0.4187
38680890	PeerJ	2024	Circular RNA circMAN1A2 promotes ovarian cancer progression through the microRNA-135a-3p/IL1RAP/TAK1 pathway.		circMAN1A2 / circ-MAN1A2	hsa_circ_MAN1A2	MAN1A2	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circMAN1A2 is up-regulated in ovarian cancer cells/tissues and promotes proliferation, colony formation, migration, and xenograft tumor growth. Mechanistically, it functions as a ceRNA that sponges miR-135a-3p, thereby increasing IL1RAP and enhancing TAK1 phosphorylation (MAPK-related signaling), which promotes ovarian cancer progression."	0.8512
38681584	Heliyon	2024	Whole transcriptome sequencing identifies a competitive endogenous RNA network that regulates the immunity of bladder cancer.	hsa_circ_0000211				bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	down-regulated	RNA-seq	This study identified hsa-circ-000211/has_circ_0000211 as a down-regulated circRNA in bladder cancer and included it in a BDNF-centered ceRNA network. It was proposed to sponge hsa-miR-107 and thereby modulate the immune-related gene BDNF in bladder cancer.	0.1768
38685915	Frontiers in molecular neuroscience	2024	Circular RNA expression profiles and functional predication after restraint stress in the amygdala of rats.		"circKCNK2(4,5,6)"	rno_circ_KCNK2	KCNK2	restraint stress	MONDO:0005084	mental disorder	up-regulated	RT-qPCR; RNA-seq	"circKCNK2(4,5,6) is up-regulated in the rat amygdala after 2 days of restraint stress and its expression correlates positively with behavioral measures in OFT/EPM. The study predicts circRNA-miRNA interactions for validated circRNAs, but does not report specific miRNAs for circKCNK2(4,5,6)."	0.7352
38685915	Frontiers in molecular neuroscience	2024	Circular RNA expression profiles and functional predication after restraint stress in the amygdala of rats.		"circCACNA2D3(5,6,7,8)"	rno_circ_CACNA2D3	CACNA2D3	restraint stress	MONDO:0005084	mental disorder	up-regulated	RT-qPCR; RNA-seq	"circCACNA2D3(5,6,7,8) is up-regulated in the rat amygdala after restraint stress and is enriched in brain tissue compared with other tissues. Bioinformatic prediction suggests it may bind rno-miR-881-5p, rno-miR-871-5p and rno-miR-743a-5p, supporting a potential miRNA-sponge role in the restraint-stress context."	0.6809
38685915	Frontiers in molecular neuroscience	2024	Circular RNA expression profiles and functional predication after restraint stress in the amygdala of rats.		"circDCC(22,23,24,25)"	rno_circ_DCC	DCC	restraint stress	MONDO:0005084	mental disorder	up-regulated	RT-qPCR; RNA-seq	"circDCC(22,23,24,25) is up-regulated in the rat amygdala after restraint stress and its expression correlates positively with anxiety-related behavioral measures. It is predicted to interact with rno-miR-433-5p, supporting a potential ceRNA/miRNA-sponge mechanism in the restraint-stress response."	0.6809
38685915	Frontiers in molecular neuroscience	2024	Circular RNA expression profiles and functional predication after restraint stress in the amygdala of rats.		"circLRP6(13,14)"	rno_circ_LRP6	LRP6	restraint stress	MONDO:0005084	mental disorder	up-regulated	RT-qPCR; RNA-seq	"circLRP6(13,14) is up-regulated in the rat amygdala after restraint stress and its expression correlates with anxiety-related behavioral measures. It is broadly expressed across multiple rat tissues, and its specific downstream molecular mechanism was not established in this study."	0.6809
38685915	Frontiers in molecular neuroscience	2024	Circular RNA expression profiles and functional predication after restraint stress in the amygdala of rats.		"circSTRN(2,3,4,5)"	rno_circ_STRN	STRN	restraint stress	MONDO:0005084	mental disorder	up-regulated	RT-qPCR; RNA-seq	"circSTRN(2,3,4,5) is up-regulated in rat amygdala after restraint stress, validated by RT-qPCR. The study predicts circRNA-miRNA networks broadly but does not report specific miRNAs or downstream targets for circSTRN(2,3,4,5)."	0.6809
38685915	Frontiers in molecular neuroscience	2024	Circular RNA expression profiles and functional predication after restraint stress in the amygdala of rats.		"circCADM1(4,5,7)"	rno_circ_CADM1		restraint stress	MONDO:0005084	mental disorder	down-regulated	RT-qPCR; RNA-seq	"circCADM1(4,5,7) is down-regulated in the rat amygdala after restraint stress and shows high specificity/enrichment in brain/amygdala across tissues. The authors suggest it could be useful as a diagnostic biomarker candidate for restraint stress, but no specific miRNA targets or downstream effectors were established."	0.6809
38686044	Oncology research	2024	Circ_0053943 complexed with IGF2BP3 drives uveal melanoma progression via regulating N6-methyladenosine modification of Epidermal growth factor receptor.	hsa_circ_0053943	circ_0053943	hsa_circ_RasGRP3	RasGRP3	uveal melanoma / UM	MONDO:0006486	uveal melanoma	up-regulated	RT-qPCR; Microarray	"circ_0053943 is up-regulated in uveal melanoma and promotes proliferation, migration/invasion, angiogenesis, and metastasis. It binds IGF2BP3 (KH1/KH2) to enhance IGF2BP3-dependent stabilization of m6A-modified EGFR mRNA, increasing EGFR expression and activating MAPK/ERK signaling."	0.8941
38686057	Oncology research	2024	Circ_0003855 involvement of esophageal cancer progression through miR-622/FLOT1.		Circ_0003855 / CircDUSP16	hsa_circ_DUSP16	DUSP16	esophageal cancer / EC	MONDO:0007576	esophageal cancer	up-regulated	RT-qPCR	"Circ_0003855 is up-regulated in Eca109 esophageal cancer cells versus normal HEEC cells. Silencing Circ_0003855 suppresses proliferation and invasion and increases apoptosis, likely by relieving miR-622 suppression and reducing FLOT1 expression, consistent with a circ_0003855/miR-622/FLOT1 regulatory axis."	0.4635
38686459	Acta biochimica et biophysica Sinica	2024	circIARS: a potential plasma biomarker for diagnosing non-small cell lung cancer.	hsa_circ_0006702	circIARS	hsa_circ_IARS	IARS	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"circIARS (hsa_circ_0006702, from IARS) is up-regulated in NSCLC tissues and plasma and shows good diagnostic performance versus controls and other lung disease groups. Its level decreases after chemotherapy/surgery and increases after recurrence, supporting use for dynamic monitoring; mechanistically, it localizes to both nucleus and cytoplasm and is predicted (bioinformatically) to act via ceRNA and/or RBP-associated networks."	0.7844
38692196	Translational oncology	2024	Exosomal circ50547 as a potential marker and promotor of gastric cancer progression via miR-217/HNF1B axis.	hsa_circ_0050547	circ50547	hsa_circ_UBA2	UBA2	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"Exosomal circ50547 (hsa_circ_0050547, from UBA2) is upregulated in gastric cancer tissues and in patient serum exosomes and shows strong diagnostic performance in exosomes. Functionally, circ50547 promotes GC cell proliferation, migration/invasion, EMT, stemness and Oxaliplatin resistance by sponging miR-217 to upregulate HNF1B, enhancing tumor growth in a cell line-derived xenograft model."	0.8584
38697972	Signal transduction and targeted therapy	2024	Cholangiocarcinoma combined with biliary obstruction: an exosomal circRNA signature for diagnosis and early recurrence monitoring.	hsa_circ_0000367				cholangiocarcinoma / CCA	MONDO:0019087	cholangiocarcinoma	up-regulated	RT-qPCR; Microarray	"hsa-circ-0000367 is enriched and up-regulated in bile and serum exosomes from CCA-BO patients. Functional knockdown reduces CCA cell proliferation/viability and migration/invasion in vitro and suppresses tumor growth/EMT-related markers in a xenograft model. Clinically, it is part of a triple-exosomal circRNA panel used to build diagnostic signatures (Bile-DS/Serum-DS) and early-recurrence monitoring models (ERS)."	0.8326
38697972	Signal transduction and targeted therapy	2024	Cholangiocarcinoma combined with biliary obstruction: an exosomal circRNA signature for diagnosis and early recurrence monitoring.	hsa_circ_0021647				cholangiocarcinoma / CCA	MONDO:0019087	cholangiocarcinoma	up-regulated	RT-qPCR; Microarray	"hsa-circ-0021647 is up-regulated in bile and serum exosomes from CCA-BO patients. Its knockdown suppresses CCA proliferation/viability and migration/invasion in vitro and limits tumor growth/EMT-related changes in vivo. Clinically, higher levels (notably in bile exosomes) are associated with early recurrence and it contributes to diagnostic and early-recurrence monitoring signatures."	0.8326
38697972	Signal transduction and targeted therapy	2024	Cholangiocarcinoma combined with biliary obstruction: an exosomal circRNA signature for diagnosis and early recurrence monitoring.	hsa_circ_0000288	hsa-0000288			cholangiocarcinoma / CCA	MONDO:0019087	cholangiocarcinoma	up-regulated	RT-qPCR; Microarray	hsa-circ-0000288 (also referred to as hsa-0000288) is up-regulated in bile and serum exosomes from CCA-BO patients. Knockdown suppresses CCA proliferation/viability and migration/invasion in vitro and reduces xenograft tumor growth with EMT marker changes. Higher levels are linked to early recurrence (notably in bile exosomes) and it is included in the triple-circRNA diagnostic and ERS recurrence-monitoring signatures.	0.8326
38702929	CNS neuroscience & therapeutics	2024	Identification of the circRNA-miRNA-mRNA network for treating methamphetamine-induced relapse and behavioral sensitization with cannabidiol.	mmu_circ_0009196	circMeis2	mmu_circ_MEIS2	MEIS2	methamphetamine-induced CPP reinstatement 	MONDO:0005419	methamphetamine dependence	down-regulated	RT-qPCR; RNA-seq	"circMeis2 is down-regulated in the nucleus accumbens in METH-treated mice and is restored by CBD. The study proposes a ceRNA mechanism where circMeis2 sponges miR-183-5p to relieve suppression of Kcnj5, contributing to CBD¡¯s effects on METH-induced CPP reinstatement and behavioral sensitization."	0.4997
38702929	CNS neuroscience & therapeutics	2024	Identification of the circRNA-miRNA-mRNA network for treating methamphetamine-induced relapse and behavioral sensitization with cannabidiol.		circTcerg1	mmu_circ_TCERG1		methamphetamine-induced CPP reinstatement 	MONDO:0005419	methamphetamine dependence	down-regulated	RT-qPCR; RNA-seq	"circTcerg1 is decreased in the nucleus accumbens in METH-treated mice in the CPP model and is restored by CBD. It is included among candidate miR-183-5p-associated circRNAs in the ceRNA network, but it was not changed in the behavioral sensitization model by RT-qPCR."	0.3684
38703060	"Cancer reports (Hoboken, N.J.)"	2024	Human circular RNA hsa_circ_0000231 clinical diagnostic effectiveness as a new tumor marker in gastric cancer.	hsa_circ_0000231	circ_0000231			gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"hsa_circ_0000231 is down-regulated in gastric cancer serum, tissues, and GC cell lines, and its postoperative increase supports use in dynamic monitoring. It shows diagnostic utility (ROC AUC 0.781) and is mainly cytoplasmic, suggesting a ceRNA/miRNA-sponge role with predicted miRNA partners (e.g., hsa-miR-26a-1-3p)."	0.6981
38704809	Discover oncology	2024	circ_WASF2 regulates ferroptosis by miR-634/ GPX4 signaling in pancreatic cancer.	hsa_circ_0000003	circ_WASF2 / circ_ WASF2	hsa_circ_WASF2	WASF2	pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"circ_WASF2 (hsa_circ_0000003) is up-regulated in pancreatic cancer cell lines and mainly localized in the cytoplasm. It promotes pancreatic cancer cell proliferation and suppresses ferroptosis-induced cell death by sponging miR-634 to upregulate GPX4, forming a circ_WASF2/miR-634/GPX4 axis."	0.7586
38705053	Translational oncology	2024	CircVDAC3 sequesters microRNA-592 and elevates EIF4E3 expression to inhibit the progression of gastric cancer.	hsa_circ_0005927	circVDAC3 / circ_0005927	hsa_circ_VDAC3	VDAC3	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"circVDAC3 (hsa_circ_0005927), derived from VDAC3, is down-regulated in gastric cancer tissues/cell lines and suppresses GC cell proliferation and metastasis in vitro and in xenograft models. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-592, thereby relieving miR-592-mediated repression of EIF4E3 to exert tumor-suppressive effects."	0.84
38710213	Cancer science	2024	Circular RNA circESYT2 serves as a microRNA-665 sponge to promote the progression of hepatocellular carcinoma through ENO2.		circESYT2 / hsa_circ_002142	hsa_circ_ESYT2	ESYT2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circESYT2 (hsa_circ_002142), derived from ESYT2, is up-regulated in HCC and mainly localized in the cytoplasm. It promotes HCC cell proliferation, migration and metastasis in vitro and in cell line-derived xenograft models by acting as a ceRNA that sponges miR-665, thereby increasing ENO2 expression; high circESYT2 is associated with worse patient prognosis."	0.8905
38711144	Journal of translational medicine	2024	Exosome-transported circ_0061407 and circ_0008103 play a tumour-repressive role and show diagnostic value in non-small-cell lung cancer.	hsa_circ_0061407	circ_0061407	hsa_circ_TIAM1	TIAM1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"Serum exosomal circ_0061407 is down-regulated in NSCLC and acts as a tumor-suppressive circRNA: its overexpression (including exosome-mediated delivery) inhibits NSCLC-related proliferation, migration/invasion, colony formation, and xenograft tumor growth. It shows diagnostic potential for NSCLC and correlates with distant metastasis/advanced stage; mechanisms were mainly predicted via miRNA/mRNA networks and RBP interactions."	0.7588
38711144	Journal of translational medicine	2024	Exosome-transported circ_0061407 and circ_0008103 play a tumour-repressive role and show diagnostic value in non-small-cell lung cancer.	hsa_circ_0008103	circ_0008103	hsa_circ_USP28	USP28	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"Serum exosomal circ_0008103 is down-regulated in NSCLC and functions as a tumor-suppressive circRNA: overexpression (including exosome-mediated transfer) reduces proliferation, migration/invasion, colony formation, and suppresses xenograft tumor growth. It has diagnostic value (high AUC) and lower levels associate with distant metastasis and more advanced tumor stage; mechanistic links were mainly bioinformatically predicted via miRNA/mRNA networks and RBP interactions."	0.7588
38714724	Communications biology	2024	Circ-0075305 hinders gastric cancer stem cells by indirectly disrupting TCF4-beta-catenin complex and downregulation of SOX9.		Circ-0075305 / Circ-MAML1	hsa_circ_MAML1	MAML1	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"Circ-0075305 is down-regulated in gastric cancer and acts as a ceRNA that sponges miR-708-5p to increase RPRD1A. Increased RPRD1A disrupts the TCF4_beta-catenin transcription complex, inhibiting Wnt/beta-catenin signaling and SOX9-related stemness, thereby suppressing proliferation/migration and enhancing oxaliplatin sensitivity; higher Circ-0075305 predicts better OS in postoperative chemotherapy patients."	0.8837
38714918	BMC genomics	2024	Identification of circRNAs expression profiles and functional networks in parotid gland of type 2 diabetes mouse.		mmu_circRNA_44427			type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RT-qPCR; Microarray	"mmu_circRNA_44427 is up-regulated in parotid glands of db/db T2DM mice. It was included in predicted ceRNA networks and may modulate actin-cytoskeleton-related targets (e.g., Fgf18, Nckap1l) via interacting with miRNAs, with broader functional enrichment pointing to inflammation/PPAR signaling involvement."	0.4851
38714918	BMC genomics	2024	Identification of circRNAs expression profiles and functional networks in parotid gland of type 2 diabetes mouse.		mmu_circRNA_002523			type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_002523 is down-regulated in parotid glands of db/db T2DM mice and was RT-qPCR-validated. Bioinformatic ceRNA analyses predict extensive miRNA interactions and downstream actin-cytoskeleton-related targets, suggesting a potential role in diabetic parotid gland injury and dysfunction."	0.4851
38714918	BMC genomics	2024	Identification of circRNAs expression profiles and functional networks in parotid gland of type 2 diabetes mouse.		mmu_circRNA_004275			type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_004275 is down-regulated in parotid glands of db/db T2DM mice and was included among the seven circRNAs used for downstream CNC/ceRNA network and enrichment analyses, but no circRNA-specific mechanism or target was individually detailed in the provided text."	0.4851
38714918	BMC genomics	2024	Identification of circRNAs expression profiles and functional networks in parotid gland of type 2 diabetes mouse.		mmu_circRNA_21009			type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_21009 is down-regulated in parotid glands of db/db T2DM mice and was among the seven qRT-PCR-validated circRNAs used for downstream CNC/ceRNA network analyses, but the manuscript excerpt does not provide a circRNA-specific target/axis for it."	0.4851
38714918	BMC genomics	2024	Identification of circRNAs expression profiles and functional networks in parotid gland of type 2 diabetes mouse.		mmu_circRNA_32858			type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_32858 is down-regulated in parotid glands of db/db T2DM mice and was part of the seven qRT-PCR-validated circRNAs used in downstream network/enrichment analyses, but no unique interacting miRNA/target or pathway assignment was provided for this circRNA in the excerpt."	0.4851
38714918	BMC genomics	2024	Identification of circRNAs expression profiles and functional networks in parotid gland of type 2 diabetes mouse.		mmu_circRNA_34309			type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RT-qPCR; Microarray	mmu_circRNA_34309 is down-regulated in parotid glands of db/db T2DM mice and was RT-qPCR-validated. It was incorporated into predicted circRNA-miRNA-mRNA networks and may influence diabetic parotid gland injury by modulating actin cytoskeleton regulation via miRNA interactions and downstream targets such as Scin.	0.4851
38714918	BMC genomics	2024	Identification of circRNAs expression profiles and functional networks in parotid gland of type 2 diabetes mouse.		mmu_circRNA_41023			type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_41023 is down-regulated in parotid glands of db/db T2DM mice and was included among the seven qRT-PCR-validated circRNAs used for downstream network and enrichment analyses, but no specific miRNA/mRNA targets or pathway effects were detailed for it in the excerpt."	0.4851
38715012	Molecular cancer	2024	circ_PPAPDC1A promotes Osimertinib resistance by sponging the miR-30a-3p/ IGF1R pathway in non-small cell lung cancer (NSCLC).		circ_PPAPDC1A / circ_100696	hsa_circ_PPAPDC1A	PPAPDC1A	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circ_PPAPDC1A is up-regulated in Osimertinib-acquired resistant NSCLC tissues/cells and promotes resistance by enhancing proliferation, invasion and migration while inhibiting apoptosis. Mechanistically, it acts as a ceRNA sponging miR-30a-3p to upregulate IGF1R and activate the PI3K/AKT/mTOR pathway, and targeting circ_PPAPDC1A can partially reverse resistance."	0.7956
38715141	Biology direct	2024	CircHIF1A induces cetuximab resistance in colorectal cancer by promoting HIF1alpha-mediated glycometabolism alteration.	hsa_circ_0007976	circHIF1A	hsa_circ_HIF1A	HIF1A	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circHIF1A (hsa_circ_0007976), derived from HIF1A, is up-regulated in cetuximab-resistant CRC cells and promotes cetuximab resistance. It functions as a ceRNA by sponging miR-361-5p to increase HIF1A/HIF1alpha and upregulate glycolysis-related enzymes (e.g., GLUT1, LDHA), enhancing glycometabolism and tumor growth; high circHIF1A in tumors predicts worse cetuximab response and shorter PFS in RAS/BRAF wild-type mCRC."	0.887
38715919	Analytical cellular pathology (Amsterdam)	2024	Hsa_circ_0051908 Promotes Hepatocellular Carcinoma Progression by Regulating the Epithelial-Mesenchymal Transition Process.	hsa_circ_0051908				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"hsa_circ_0051908 is up-regulated in HCC tissues and cell lines and functions as an oncogenic circRNA. Its knockdown suppresses proliferation, migration and invasion, increases apoptosis, and inhibits EMT-associated marker changes (E-cadherin up; vimentin/Snail down), reducing xenograft tumor growth."	0.622
38720708	Heliyon	2024	Inhibition of circRNA NGFR promotes ferroptosis in gallbladder carcinoma cells.		circRNA NGFR			gallbladder carcinoma / GBC	MONDO:0003220	gallbladder carcinoma	up-regulated	RT-qPCR; RNA-seq	"circRNA NGFR is upregulated in gallbladder carcinoma cells and functionally supports tumor cell proliferation. Knockdown of NGFR induces ferroptosis and mitochondrial dysfunction, involving HO-1/FTH signaling and altered ferroptosis-related proteins (xCT/GPX4)."	0.4636
38724502	Nature communications	2024	circCDK13-loaded small extracellular vesicles accelerate healing in preclinical diabetic wound models.	hsa_circ_0079929	circCDK13	hsa_circ_CDK13	CDK13	diabetic wounds	MONDO:0005015	diabetes mellitus	down-regulated	RT-qPCR; Microarray	"circCDK13 (hsa_circ_0079929), derived from CDK13, is down-regulated in diabetic wounds/DFU. It promotes fibroblast and keratinocyte proliferation and migration by interacting with IGF2BP3 in an m6A-dependent manner, enhancing CD44 and c-MYC (via mRNA stability). circCDK13-loaded sEVs accelerate healing in db/db diabetic mice and STZ-induced diabetic rats, supporting a therapeutic delivery strategy for diabetic wounds."	0.8066
38726183	Heliyon	2024	Paeoniflorin inhibits the inflammation of rheumatoid arthritis fibroblast-like synoviocytes by downregulating hsa_circ_009012.		hsa_circ_009012			Rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"hsa_circ_009012 is up-regulated in RA-FLS and promotes inflammatory responses and aggressive cellular phenotypes (proliferation, cell-cycle progression, migration/invasion). It is proposed to act via a ceRNA mechanism involving miR-1286 and downstream TLR4/NLRP3, and paeoniflorin suppresses RA-FLS inflammation partly by downregulating hsa_circ_009012 and modulating this axis."	0.4635
38730434	BMC urology	2024	CircPRELID2 functions as a promoter of renal cell carcinoma through the miR-22-3p/ETV1 cascade.	hsa_circ_0006528	circPRELID2	hsa_circ_PRELID2	PRELID2	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR	"circPRELID2 is up-regulated in renal cell carcinoma and promotes malignant phenotypes (proliferation, migration/motility, invasion) and xenograft tumor growth. Mechanistically, it acts as a miR-22-3p sponge to upregulate ETV1, and its knockdown also weakens M2-type macrophage polarization."	0.8635
38737931	Gastroenterology and hepatology from bed to bench	2024	Investigation of GNB1 derivative circular RNAs hsa_circ_0009361 and hsa_circ_0009362 expressions in colorectal cancer patients: potential new diagnostic factors.	hsa_circ_0009361	circGNB1	hsa_circ_GNB1	GNB1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	hsa_circ_0009361 is significantly down-regulated in colorectal cancer tissues versus paired adjacent control tissues and shows diagnostic potential in distinguishing CRC from controls (AUC 0.85).	0.4187
38737931	Gastroenterology and hepatology from bed to bench	2024	Investigation of GNB1 derivative circular RNAs hsa_circ_0009361 and hsa_circ_0009362 expressions in colorectal cancer patients: potential new diagnostic factors.	hsa_circ_0009362	circGNB1	hsa_circ_GNB1	GNB1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	hsa_circ_0009362 is significantly down-regulated in colorectal cancer tissues versus paired adjacent control tissues and has diagnostic potential for CRC (AUC 0.69).	0.4187
38742566	Cancer biology & therapy	2024	Exosome-transmitted circular RNA circ-LMO7 facilitates the progression of osteosarcoma by regulating miR-21-5p/ARHGAP24 axis.	hsa_circ_0088259	CircLMO7 / circ-LMO7	hsa_circ_LMO7	LMO7	osteosarcoma / OS	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR	"circ-LMO7 (hsa_circ_0088259) is down-regulated in osteosarcoma cells/tissues and functions as a tumor suppressor. It is mainly cytoplasmic and can be packaged into exosomes; it sponges miR-21-5p to relieve repression of ARHGAP24, thereby inhibiting OS cell proliferation, migration and invasion and promoting apoptosis."	0.7922
38745044	Communications biology	2024	ALKBH5-mediated m6A modification of circFOXP1 promotes gastric cancer progression by regulating SOX4 expression and sponging miR-338-3p.	hsa_circ_0008234	circFOXP1 / circ-FOXP1	hsa_circ_FOXP1	FOXP1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circFOXP1 is up-regulated in gastric cancer and its high expression correlates with aggressive clinicopathologic features and poor survival. Functionally, circFOXP1 promotes proliferation, invasion, and cell-cycle progression and enhances tumor growth in vivo. Mechanistically, ALKBH5-mediated m6A modification regulates circFOXP1, which acts as a ceRNA by sponging miR-338-3p to increase SOX4 expression."	0.834
38747117	The clinical respiratory journal	2024	CircST6GAL1 knockdown alleviates pulmonary arterial hypertension by regulating miR-509-5p/multiple C2 and transmembrane domain containing 2 axis.	hsa_circ_0068481	CircST6GAL1	hsa_circ_ST6GAL1	ST6GAL1	pulmonary arterial hypertension / PAH	MONDO:0015924	pulmonary arterial hypertension	up-regulated	RT-qPCR	"CircST6GAL1 is up-regulated in PAH patient serum and in hypoxia-treated HPASMCs, and it promotes HPASMC proliferation and migration while inhibiting apoptosis. Mechanistically, it sponges miR-509-5p to increase MCTP2 expression (circST6GAL1/miR-509-5p/MCTP2 axis), and its knockdown alleviates pulmonary vascular remodeling in an MCT-induced PAH mouse model."	0.8738
38748048	Discover oncology	2024	circ_0006789 promotes cervical cancer development via the miR-615-5p/HSF1 axis.	hsa_circ_0006789	circ_0006789 / circSLC25A43	hsa_circ_SLC25A43	SLC25A43	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ_0006789 (circSLC25A43) is upregulated in cervical cancer tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion; inhibits apoptosis) and xenograft tumor growth. Mechanistically, it mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-615-5p to increase HSF1 expression, with rescue by miR-615-5p inhibition or HSF1 overexpression."	0.8069
38748254	"Cancer immunology, immunotherapy : CII"	2024	circATAD2 mitigates CD8+ T cells antitumor immune surveillance in breast cancer via IGF2BP3/m6A/PD-L1 manner.	hsa_circ_0085465	circATAD2	hsa_circ_ATAD2	ATAD2	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circATAD2 (hsa_circ_0085465) is upregulated in breast cancer and is associated with worse overall survival. It promotes immune evasion by binding PD-L1 mRNA and facilitating IGF2BP3-dependent recognition of m6A in the PD-L1 3'-UTR, thereby stabilizing PD-L1 mRNA and increasing PD-L1 expression, which reduces CD8+ T cell cytotoxicity."	0.8532
38750560	Molecular brain	2024	Moxibustion ameliorates chronic inflammatory visceral pain via spinal circRNA-miRNA-mRNA networks: a central mechanism study.		circRNA_02767 / circRNA 02767			inflammatory bowel disease	MONDO:0005265	inflammatory bowel disease	up-regulated	RT-qPCR; RNA-seq	"In TNBS-induced CIVP rats, circRNA_02767 is up-regulated in spinal cord tissue and participates in a ceRNA network with rno-miR-483-3p and Gfap. Herb-partitioned moxibustion down-regulates circRNA_02767, up-regulates rno-miR-483-3p, and reduces Gfap mRNA, which may contribute to reduced central sensitization and visceral pain."	0.3684
38750560	Molecular brain	2024	Moxibustion ameliorates chronic inflammatory visceral pain via spinal circRNA-miRNA-mRNA networks: a central mechanism study.		circRNA_09943			inflammatory bowel disease	MONDO:0005265	inflammatory bowel disease	up-regulated	RNA-seq	"circRNA_09943 is up-regulated in spinal cord tissue of CIVP model rats and was included in a proposed ceRNA network with rno-miR-203a-3p and Aurkb. Although sequencing/qRT-PCR verification was attempted for this network, changes of circRNA_09943 (and Aurkb mRNA) after moxibustion were not statistically significant, so functional support is weaker than for circRNA_02767."	0.31
38752261	Technology in cancer research & treatment	2024	CircAGFG1 Promotes Ovarian Cancer Progression Through the miR-409-3 p/ZEB1 Axis.		circAGFG1 / Circular RNA ArfGAP with FG repeats 1	hsa_circ_AGFG1		ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circAGFG1 is up-regulated in ovarian cancer tissues/cell lines and promotes OC cell proliferation and metastatic behaviors. It functions mainly as a cytoplasmic ceRNA that sponges miR-409-3p, thereby increasing ZEB1 expression and facilitating EMT, and high circAGFG1 predicts poor survival."	0.7756
38755265	Communications biology	2024	M2 macrophage-derived exosomal circTMCO3 acts through miR-515-5p and ITGA8 to enhance malignancy in ovarian cancer.	hsa_circ_0031017	circTMCO3	hsa_circ_TMCO3	TMCO3	ovarian cancer	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; Northern Blot	"In ovarian cancer, M2 macrophage-derived exosomes deliver circTMCO3, which promotes malignant phenotypes (proliferation, migration, invasion and EMT) and accelerates in vivo tumor progression. Mechanistically, circTMCO3 acts as a ceRNA sponge for miR-515-5p, leading to ITGA8 upregulation and poorer patient survival associated with high circTMCO3."	0.8851
38755678	Molecular cancer	2024	CircTRIM1 encodes TRIM1-269aa to promote chemoresistance and metastasis of TNBC via enhancing CaM-dependent MARCKS translocation and PI3K/AKT/mTOR activation.	hsa_circ_0002153	circTRIM1	hsa_circ_TRIM1	TRIM1	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circTRIM1 (hsa_circ_0002153), derived from TRIM1, is up-regulated in doxorubicin-resistant TNBC cells and chemoresistant TNBC tissues and predicts poor prognosis. It functions mainly through encoding the peptide TRIM1-269aa, which promotes chemoresistance and metastasis by enhancing calmodulin-dependent MARCKS translocation and activating PI3K/AKT/mTOR signaling, and TRIM1-269aa can be transmitted via exosomes between TNBC cells."	0.904
38771413	Metabolic brain disease	2024	"Hsa_circ_0004872 mitigates proliferation, metastasis and immune escape of meningioma cells by suppressing PD-L1."	hsa_circ_0004872		hsa_circ_MAPK1	MAPK1	meningioma	MONDO:0016642	meningioma	down-regulated	RT-qPCR	"hsa_circ_0004872 is down-regulated in meningioma tissues and cell lines and functions as a tumor-suppressive circRNA. It binds the RBP EIF4A3, interferes with EIF4A3_PD-L1 mRNA association, decreases PD-L1 mRNA stability/expression, and thereby inhibits proliferation/metastasis traits and immune escape while enhancing CD8+ T-cell cytotoxicity."	0.7591
38773094	Cell death & disease	2024	Energy stress-induced circDDX21 promotes glycolysis and facilitates hepatocellular carcinogenesis.	hsa_circ_0008523	circDDX21	hsa_circ_DDX21	DDX21	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"In hepatocellular carcinoma, circDDX21 is upregulated and promotes glycolysis and tumor growth. It binds the RBP PABPC1, reduces MKRN3-mediated PABPC1 ubiquitination, enhances PABPC1 binding to PGAM1 mRNA, and stabilizes PGAM1 mRNA to increase PGAM1 expression."	0.8547
38778089	Cancer gene therapy	2024	IGF2BP2-modified circular RNA circCHD7 promotes endometrial cancer progression via stabilizing PDGFRB and activating JAK/STAT signaling pathway.	hsa_circ_0084582	circCHD7	hsa_circ_CHD7	CHD7	endometrial cancer / EC	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR	"circCHD7 (hsa_circ_0084582) is upregulated in endometrial cancer and mainly localizes to the cytoplasm. It binds the m6A reader IGF2BP2, enhances PDGFRB mRNA stability in an m6A-dependent manner, activates JAK/STAT signaling, and thereby promotes EC proliferation and tumor growth while inhibiting apoptosis."	0.8817
38782541	Journal for immunotherapy of cancer	2024	Exosomal circPOLQ promotes macrophage M2 polarization via activating IL-10/STAT3 axis in a colorectal cancer model.		circPOLQ / circRNAPOLQ	hsa_circ_POLQ	POLQ	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circPOLQ is up-regulated in colorectal cancer tissues and enriched in CRC cell-derived exosomes. After being transferred into macrophages, circPOLQ sponges miR-379_3p to increase IL-10 and activate STAT3 signaling, promoting M2 polarization and enhancing CRC invasion/metastatic nodule formation. High circPOLQ expression correlates with poorer overall survival in CRC patients."	0.8693
38795544	Redox biology	2024	circMIRIAF aggravates myocardial ischemia-reperfusion injury via targeting miR-544/WDR12 axis.	hsa_circ_0006174	circMIRIAF / hsa_circRNA_104852	hsa_circ_RAD23B	RAD23B	myocardial ischemia/reperfusion injury	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR; Microarray	"circMIRIAF (hsa_circ_0006174; RAD23B-derived) is up-regulated in cardiomyocytes under H/RI and in MI/RI models. It functions as a ceRNA by sponging miR-544, thereby increasing WDR12 and modulating the WDR12/Notch1-associated oxidative stress and inflammatory response to aggravate injury; circMIRIAF silencing alleviates these effects."	0.6993
38795544	Redox biology	2024	circMIRIAF aggravates myocardial ischemia-reperfusion injury via targeting miR-544/WDR12 axis.	mmu_circ_0011688	circMIRIAF / circRNA MI	mmu_circ_RAD23B	RAD23B	myocardial ischemia/reperfusion injury	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR	"In mice, the RAD23B-derived circMIRIAF (mmu_circ_0011688) is increased during MI/RI. Knockdown of circMIRIAF via shRNA elevates miR-544, reverses WDR12/Notch1-related molecular changes, and alleviates MI/RI-associated pathological injury and inflammatory/oxidative stress responses."	0.414
38795560	Translational oncology	2024	Regulatory feedback loop between circ-EIF4A3 and EIF4A3 Enhances autophagy and growth in colorectal cancer cells.	hsa_circ_0006749	circEIF4A3 / circ-EIF4A3	hsa_circ_EIF4A3	EIF4A3	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circEIF4A3 (hsa_circ_0006749) is upregulated in colorectal cancer cells and promotes proliferation/tumor growth while reducing apoptosis. Mechanistically, it sponges miR-3126_5p to increase EIF4A3, forming a positive feedback loop in which EIF4A3 also enhances circEIF4A3 biogenesis; elevated EIF4A3 promotes autophagy by stabilizing ATG5 mRNA and USP14 mRNA to increase ATG7 protein stability."	0.8378
38799570	iScience	2024	Circ_0007432 promotes non-small cell lung cancer progression and macrophage M2 polarization through SRSF1/KLF12 axis.	hsa_circ_0007432	circ_0007432	hsa_circ_PMM2	PMM2	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0007432 is up-regulated in NSCLC tissues/cells and mainly localized in the cytoplasm. It promotes NSCLC malignant phenotypes and tumor growth and drives macrophage M2 polarization by binding SRSF1 to stabilize KLF12 mRNA, which in turn transcriptionally activates IL-8 and increases IL-8 release. High circ_0007432 expression is associated with poor patient prognosis."	0.8831
38802795	Molecular cancer	2024	CircPIAS1 promotes hepatocellular carcinoma progression by inhibiting ferroptosis via the miR-455-3p/NUPR1/FTH1 axis.	hsa_circ_0007088	CircPIAS1	hsa_circ_PIAS1	PIAS1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circPIAS1 is up-regulated in HCC and promotes proliferation, migration and in vivo tumor progression. It suppresses ferroptosis via a ceRNA mechanism by sponging miR-455-3p to upregulate NUPR1, which transcriptionally activates FTH1, increasing iron storage and ferroptosis resistance. High circPIAS1 expression is associated with worse overall survival and may contribute to lenvatinib resistance."	0.898
38802851	Journal of translational medicine	2024	A novel protein FNDC3B-267aa encoded by circ0003692 inhibits gastric cancer metastasis via promoting proteasomal degradation of c-Myc.	hsa_circ_0003692	circ0003692 / circFNDC3B	hsa_circ_FNDC3B	FNDC3B	Gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; ISH	"circ0003692 (hsa_circ_0003692), derived from FNDC3B, is down-regulated in gastric cancer tissues and associates with advanced TNM grades. It acts mainly by encoding the peptide FNDC3B-267aa, which binds c-Myc and promotes its proteasomal degradation, thereby suppressing the c-Myc_Snail/Slug axis and reducing GC migration/metastasis."	0.8707
38803052	Thoracic cancer	2024	CircSLC25A16 facilitates the development of non-small-cell lung cancer through the miR-335-5p/CISD2 axis.	hsa_circ_0018534	circSLC25A16	hsa_circ_SLC25A16	SLC25A16	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circSLC25A16 is up-regulated in NSCLC tissues and cell lines and promotes proliferation, migration and glycolysis while suppressing apoptosis. Mechanistically, it sponges miR-335-5p to increase CISD2 expression, thereby enhancing NSCLC progression and xenograft tumor growth."	0.8172
38803355	Cell stress	2024	"CircRNA regulates the liquid-liquid phase separation of ATG4B, a novel strategy to inhibit cancer metastasis?"		circSPECC1		SPECC1	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; RNA-seq	"In gastric cancer cells, circSPECC1 is down-regulated and functions as an ATG4B-binding circRNA that promotes ATG4B LLPS and RNF5-mediated ubiquitination, thereby reducing ATG4B protein levels to promote anoikis and suppress metastasis. ELAVL1 acts as an m6A reader that binds circSPECC1 and inhibits its expression, while lopinavir restores circSPECC1 abundance and suppresses GC metastasis."	0.6157
38803428	Analytical cellular pathology (Amsterdam)	2024	Identification of circRNA Expression Profile and Potential Systemic Immune Imbalance Modulation in Premature Rupture of Membranes.	hsa_circ_0113207		hsa_circ_AGO1	AGO1	Premature rupture of membranes / PROM	MONDO:0012511	preterm premature rupture of the membranes	up-regulated	Microarray	"hsa_circ_0113207 is upregulated in prenatal plasma of PROM patients in the microarray screen and is part of the top circRNAs used to build a predicted circRNA_miRNA_mRNA network, implicating immune-inflammatory and extracellular-matrix related processes."	0.1768
38803428	Analytical cellular pathology (Amsterdam)	2024	Identification of circRNA Expression Profile and Potential Systemic Immune Imbalance Modulation in Premature Rupture of Membranes.	hsa_circ_0036309	hsa-circRNA10825-2	hsa_circ_SCAMP2	SCAMP2	Premature rupture of membranes / PROM	MONDO:0012511	preterm premature rupture of the membranes	up-regulated	Microarray	hsa_circ_0036309 (alias hsa-circRNA10825-2; host gene SCAMP2) is upregulated in prenatal plasma of PROM patients and was included among the top dysregulated circRNAs used to construct a predicted circRNA_miRNA_mRNA regulatory network related to immune-inflammatory processes.	0.1768
38803428	Analytical cellular pathology (Amsterdam)	2024	Identification of circRNA Expression Profile and Potential Systemic Immune Imbalance Modulation in Premature Rupture of Membranes.	hsa_circ_0058909	hsa-circRNA12935-3	hsa_circ_HDAC4	HDAC4	Premature rupture of membranes / PROM	MONDO:0012511	preterm premature rupture of the membranes	up-regulated	Microarray	hsa_circ_0058909 (alias hsa-circRNA12935-3; host gene HDAC4) is upregulated in prenatal plasma of PROM and was among the top dysregulated circRNAs used for downstream ceRNA-based functional enrichment suggesting immune-inflammatory involvement.	0.1768
38803428	Analytical cellular pathology (Amsterdam)	2024	Identification of circRNA Expression Profile and Potential Systemic Immune Imbalance Modulation in Premature Rupture of Membranes.	hsa_circ_0022322	hsa-circRNA9507-4	hsa_circ_CYB561A3	CYB561A3	Premature rupture of membranes / PROM	MONDO:0012511	preterm premature rupture of the membranes	up-regulated	Microarray	hsa_circ_0022322 (alias hsa-circRNA9507-4; host gene CYB561A3) is upregulated in prenatal plasma of PROM and was included among key circRNAs used to infer ceRNA networks linked to immune-inflammatory abnormalities in PROM.	0.1768
38803428	Analytical cellular pathology (Amsterdam)	2024	Identification of circRNA Expression Profile and Potential Systemic Immune Imbalance Modulation in Premature Rupture of Membranes.	hsa_circ_0061419	hsa-circRNA13167-22	hsa_circ_SCAF4	SCAF4	Premature rupture of membranes / PROM	MONDO:0012511	preterm premature rupture of the membranes	up-regulated	Microarray	hsa_circ_0061419 (alias hsa-circRNA13167-22; host gene SCAF4) is upregulated in prenatal plasma of PROM and was used as a key circRNA for predicted ceRNA network and enrichment analyses implicating immune-inflammatory pathways.	0.1768
38803428	Analytical cellular pathology (Amsterdam)	2024	Identification of circRNA Expression Profile and Potential Systemic Immune Imbalance Modulation in Premature Rupture of Membranes.	hsa_circ_0096021		hsa_circ_DAK	DAK	Premature rupture of membranes / PROM	MONDO:0012511	preterm premature rupture of the membranes	down-regulated	Microarray	"hsa_circ_0096021 is downregulated in PROM plasma and remains significantly dysregulated postpartum; its levels correlate strongly with peripheral leukocyte proportions, suggesting a link to systemic immune imbalance in PROM via a proposed circRNA_miRNA_mRNA framework."	0.1768
38803428	Analytical cellular pathology (Amsterdam)	2024	Identification of circRNA Expression Profile and Potential Systemic Immune Imbalance Modulation in Premature Rupture of Membranes.	hsa_circ_0092529		hsa_circ_NEURL1	NEURL1	Premature rupture of membranes / PROM	MONDO:0012511	preterm premature rupture of the membranes	down-regulated	Microarray	hsa_circ_0092529 is downregulated in PROM plasma and is one of the key circRNAs that remains significantly dysregulated postpartum; it was included in bioinformatic ceRNA/network analyses relating circRNA dysregulation to immune-inflammatory processes in PROM.	0.1768
38803428	Analytical cellular pathology (Amsterdam)	2024	Identification of circRNA Expression Profile and Potential Systemic Immune Imbalance Modulation in Premature Rupture of Membranes.	hsa_circ_0056502	hsa-circRNA4637-5			Premature rupture of membranes / PROM	MONDO:0012511	preterm premature rupture of the membranes	down-regulated	Microarray	hsa_circ_0056502 (alias hsa-circRNA4637-5) is downregulated in prenatal plasma of PROM and was included among top dysregulated circRNAs used to build predicted circRNA_miRNA_mRNA networks related to systemic immune imbalance in PROM.	0.1768
38803428	Analytical cellular pathology (Amsterdam)	2024	Identification of circRNA Expression Profile and Potential Systemic Immune Imbalance Modulation in Premature Rupture of Membranes.	hsa_circ_0033779	hsa-circRNA10608-230			Premature rupture of membranes / PROM	MONDO:0012511	preterm premature rupture of the membranes	down-regulated	Microarray	hsa_circ_0033779 (alias hsa-circRNA10608-230) is downregulated in prenatal plasma of PROM and was included among key circRNAs supporting a bioinformatic ceRNA framework linking circRNA dysregulation to immune imbalance in PROM.	0.1768
38803428	Analytical cellular pathology (Amsterdam)	2024	Identification of circRNA Expression Profile and Potential Systemic Immune Imbalance Modulation in Premature Rupture of Membranes.	hsa_circ_0078356	hsa-circRNA6940-1	hsa_circ_SCAF8	SCAF8	Premature rupture of membranes / PROM	MONDO:0012511	preterm premature rupture of the membranes	down-regulated	Microarray	hsa_circ_0078356 (alias hsa-circRNA6940-1; host gene SCAF8) is downregulated in PROM plasma and remains significantly dysregulated postpartum; it was treated as a key circRNA in bioinformatic analyses implicating systemic immune imbalance in PROM.	0.1768
38806577	Scientific reports	2024	Circ_0001671 regulates prostate cancer progression through miR-27b-3p/BLM axis.	hsa_circ_0001671	circ_0001671	hsa_circ_EIF3B	EIF3B	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"hsa_circ_0001671 (circ_0001671), derived from EIF3B, is up-regulated in prostate cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes proliferation, migration, invasion and tumor growth while inhibiting apoptosis by sponging miR-27b-3p to upregulate BLM (circ_0001671/miR-27b-3p/BLM ceRNA axis)."	0.8748
38808547	Journal of biomedical research	2024	Genetic variation of circHIBADH enhances prostate cancer risk through regulating HNRNPA1-related RNA splicing.	hsa_circ_0006773	circHIBADH	hsa_circ_HIBADH	HIBADH	prostate cancer / PCa	MONDO:0008315	prostate cancer	down-regulated	RNA-seq	"circHIBADH is down-regulated in prostate cancer tumors versus adjacent normal tissue and is proposed to function as a protein sponge for RNA splicing-associated RBPs, especially HNRNPA1. The risk variant rs11973492 may reduce circHIBADH biogenesis by altering RNA secondary structure, weakening RBP sponging and thereby facilitating RNA-splicing-linked carcinogenic programs (e.g., MYC target, DNA repair, E2F target)."	0.348
38811968	Journal of nanobiotechnology	2024	Exosome-derived circUPF2 enhances resistance to targeted therapy by redeploying ferroptosis sensitivity in hepatocellular carcinoma.	hsa_circ_0017702	circUPF2	hsa_circ_UPF2	UPF2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"This study identifies exosome-enriched circUPF2 (hsa_circ_0017702) as an effector of acquired sorafenib resistance in HCC. circUPF2 serves as a cytoplasmic scaffold recruiting IGF2BP2 and SLC7A11 mRNA to form a ternary complex that stabilizes SLC7A11 mRNA, enhances system Xc_ activity, suppresses ferroptosis, and reduces sorafenib efficacy in vitro and in xenografts."	0.8546
38812291	Journal of biomedical research	2024	Expression profiling and bioinformatics analysis of serum exosomal circular RNAs in lymph node metastasis of papillary thyroid carcinoma.		circTACC2	hsa_circ_TACC2	TACC2	papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; RNA-seq	"This study identified exosomal circTACC2 as up-regulated in serum exosomes from PTC patients with lymph node metastasis and preliminarily validated its expression. Bioinformatics/ceRNA analysis suggests circTACC2 may sponge miR-7 to increase EGFR, potentially promoting metastatic progression via EGFR-associated signaling (e.g., PI3K/AKT)."	0.4685
38812291	Journal of biomedical research	2024	Expression profiling and bioinformatics analysis of serum exosomal circular RNAs in lymph node metastasis of papillary thyroid carcinoma.		circBIRC6	hsa_circ_BIRC6	BIRC6	papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR; RNA-seq	"This study found exosomal circBIRC6 is down-regulated in PTC with lymph node metastasis and preliminarily validated its expression by RT-qPCR. The proposed mechanism is a ceRNA axis where circBIRC6 regulates miR-24-3p and the apoptosis-related gene BCL2L11, potentially contributing to PTC progression and metastasis."	0.4685
38813026	Turkish journal of medical sciences	2023	Hsa-circ-0006091 modulates the proliferation of hepatocellular carcinoma via the miR-622/CCNB1 axis.	hsa_circ_0006091	circular RNA-0006091 / circ-0006091	hsa_circ_RGS12	RGS12	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ-0006091 is up-regulated in HCC tissues and HCC cell lines and promotes migration/invasion and in vivo tumor growth. Mechanistically, it functions as a miRNA sponge for miR-622 to increase CCNB1 expression, forming a circ-0006091/miR-622/CCNB1 regulatory axis."	0.74
38816350	Cancer biology & therapy	2024	Circ_RPPH1 facilitates progression of breast cancer via miR-1296-5p/TRIM14 axis.		circ_RPPH1	hsa_circ_RPPH1		breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_RPPH1 is up-regulated in breast cancer tissues and promotes malignant behaviors (proliferation, migration, invasion), shifts the cell cycle toward S phase, and inhibits apoptosis. Mechanistically, it functions as a ceRNA by binding miR-1296-5p to de-repress TRIM14, enhancing tumor growth in a xenograft model."	0.7133
38816735	Journal of translational medicine	2024	"CircDCAF8 promotes the progression of hepatocellular carcinoma through miR-217/NAP1L1 Axis, and induces angiogenesis and regorafenib resistance via exosome-mediated transfer."	hsa_circ_0014879	circDCAF8	hsa_circ_DCAF8	DCAF8	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"CircDCAF8 (hsa_circ_0014879), derived from the DCAF8 gene, is upregulated in HCC and promotes tumor proliferation, migration, invasion and EMT. It functions as a ceRNA by sponging miR-217 to increase NAP1L1, and it can be transferred via exosomes to enhance angiogenesis and to transmit regorafenib resistance."	0.8462
38819228	Aging	2024	circRNA6448-14/miR-455-3p/OTUB2 axis stimulates glycolysis and stemness of esophageal squamous cell carcinoma.		circRNA6448-14 / hsa_circ RNA6448-14			esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circRNA6448-14 is up-regulated in ESCC and promotes ESCC cell glycolysis and stemness. Mechanistically, it sponges miR-455-3p to increase OTUB2 expression, and OTUB2 overexpression or miR-455-3p inhibition rescues the effects of circRNA6448-14 knockdown."	0.6528
38820386	PloS one	2024	Circ_0000006 and circ_0000160 regulate hsa-let-7e-5p/UBQLN4 axis in aortic dissection progression.	hsa_circ_0000006	circ_0000006			aortic dissection / AD	MONDO:0022470	aortic dissection lentiginosis	up-regulated	RT-qPCR; Microarray	"circ_0000006 is up-regulated in AD (vs AA) in plasma and promotes PDGF-induced VSMC phenotypic switching, proliferation and migration. Mechanistically, it functions in a ceRNA axis by inhibiting hsa-let-7e-5p, thereby increasing UBQLN4 and contributing to AA-to-AD progression; its knockdown alleviates disease features in an AD mouse model."	0.6593
38820386	PloS one	2024	Circ_0000006 and circ_0000160 regulate hsa-let-7e-5p/UBQLN4 axis in aortic dissection progression.	hsa_circ_0000160	circ_0000160			aortic dissection / AD	MONDO:0022470	aortic dissection lentiginosis	up-regulated	RT-qPCR; Microarray	"circ_0000160 is up-regulated in AD (vs AA) in plasma and promotes PDGF-induced VSMC phenotypic switching, proliferation and migration. It participates in a ceRNA axis by inhibiting hsa-let-7e-5p, increasing UBQLN4, and its knockdown reduces AD progression in a BAPN/angiotensin II-induced mouse model."	0.6593
38824581	BMC cancer	2024	Identification and diagnostic potential of hsa_circ_101303 in colorectal cancer: unraveling a regulatory network.		hsa_circ_101303 / hsa_circRNA101303	hsa_circ_LAMP1	LAMP1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_101303 is up-regulated in colorectal cancer tissues and is also elevated in patient plasma, showing moderate diagnostic performance (AUC 0.738). The study builds a predicted ceRNA network in CRC linking hsa_circ_101303 to nine miRNAs and downstream genes, suggesting a potential regulatory role in CRC progression."	0.5047
38827325	Oncology research	2024	CircMYBL2 facilitates hepatocellular carcinoma progression by regulating E2F1 expression.	hsa_circ_0060467	CircMYBL2	hsa_circ_MYBL2	MYBL2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circMYBL2 is up-regulated in HCC tissues and cell lines and promotes HCC cell proliferation and migration. It functions as a ceRNA by sponging miR-1205, thereby increasing E2F1 expression and accelerating HCC progression, and is proposed as a potential therapeutic target/prognostic biomarker."	0.8487
38828010	Regenerative therapy	2024	CircRNA SEC24A promotes osteoarthritis through miR-107-5p/CASP3 axis.	hsa_circ_0073966	circSEC24A / circRNA SEC24A	hsa_circ_SEC24A	SEC24A	Osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circSEC24A is up-regulated in OA cartilage and IL-1beta-stimulated chondrocytes and promotes OA progression. Mechanistically, it sponges miR-107-5p to derepress CASP3, thereby increasing chondrocyte apoptosis and enhancing ECM degradation and inflammatory cytokine changes; circSEC24A silencing alleviates OA in an ACLT rat model."	0.674
38828155	Acta pharmaceutica Sinica. B	2024	Cisplatin-based miRNA delivery strategy inspired by the circCPNE1/miR-330-3p pathway for oral squamous cell carcinoma.	hsa_circ_0001146	circCPNE1	hsa_circ_CPNE1	CPNE1	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR; ISH	"circCPNE1 (hsa_circ_0001146) is down-regulated in OSCC tissues and cell lines and is negatively associated with clinical stage. Functionally, circCPNE1 suppresses OSCC proliferation, migration, invasion and xenograft growth by acting as a cytoplasmic miR-330-3p sponge, thereby relieving repression of SOX6 and affecting AKT/Bcl-2 levels."	0.8254
38828320	Heliyon	2024	Exosomal circ_0084043 derived from colorectal cancer-associated fibroblasts promotes in vitro endothelial cell angiogenesis by regulating the miR-140-3p/HIF-1alpha/VEGF signaling axis.	hsa_circ_0060745	circ_0060745			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	circ_0060745 is up-regulated in CRC patient serum and shows diagnostic potential for distinguishing CRC from healthy controls (AUC 0.85).	0.4187
38828320	Heliyon	2024	Exosomal circ_0084043 derived from colorectal cancer-associated fibroblasts promotes in vitro endothelial cell angiogenesis by regulating the miR-140-3p/HIF-1alpha/VEGF signaling axis.		circ_001569			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	circ_001569 is up-regulated in CRC patient serum and shows good diagnostic performance for CRC detection (AUC 0.91).	0.4187
38828320	Heliyon	2024	Exosomal circ_0084043 derived from colorectal cancer-associated fibroblasts promotes in vitro endothelial cell angiogenesis by regulating the miR-140-3p/HIF-1alpha/VEGF signaling axis.	hsa_circ_0007142	circ_007142 / circ_0007142			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	circ_007142/circ_0007142 is up-regulated in CRC patient serum and can discriminate CRC from healthy controls (AUC 0.92).	0.4187
38828320	Heliyon	2024	Exosomal circ_0084043 derived from colorectal cancer-associated fibroblasts promotes in vitro endothelial cell angiogenesis by regulating the miR-140-3p/HIF-1alpha/VEGF signaling axis.	hsa_circ_0084043	circ_0084043 / circ-0084043			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"Exosomal circ_0084043 is up-regulated in CRC patient serum and is enriched in CAF-derived exosomes. After transfer into endothelial cells, it promotes proliferation/migration and angiogenesis by sponging miR-140_3p, thereby increasing HIF-1alpha and VEGFA and enhancing VEGF signaling; it also shows strong diagnostic performance (AUC 0.93)."	0.7126
38828320	Heliyon	2024	Exosomal circ_0084043 derived from colorectal cancer-associated fibroblasts promotes in vitro endothelial cell angiogenesis by regulating the miR-140-3p/HIF-1alpha/VEGF signaling axis.		Circ_BANP / Circ-BANP	hsa_circ_BANP	BANP	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	Circ_BANP is up-regulated in CRC patient serum and can serve as a diagnostic biomarker (AUC 0.81).	0.4187
38828320	Heliyon	2024	Exosomal circ_0084043 derived from colorectal cancer-associated fibroblasts promotes in vitro endothelial cell angiogenesis by regulating the miR-140-3p/HIF-1alpha/VEGF signaling axis.		CiRS-7			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"CiRS-7 is elevated in CRC patient serum and shows diagnostic value for CRC detection (AUC 0.79), but it was not correlated with lymph node metastasis or TNM stage in this study."	0.4187
38835801	Frontiers in medicine	2024	Construction of competing endogenous RNA networks in systemic lupus erythematosus by integrated analysis.	hsa_circ_0000345	circ 0000345			systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	unknown	Microarray	"This study identified a circRNA-centered ceRNA axis involving HSA circ 0000345, miR-22-3p, and the targets ESR1/SIRT1 in SLE. The authors propose it may impact SLE pathogenesis and could be a biomarker or therapeutic target, but experimental validation is not provided."	0.1768
38836972	Discover oncology	2024	Nomograms incorporating hsa_circ_0029325 highly expressed in exosomes of hepatocellular carcinoma predict the postoperative outcomes.	hsa_circ_0029325				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH; Microarray	Exosomal hsa_circ_0029325 is up-regulated in HCC (plasma and tissue-derived exosomes) and higher expression is associated with higher recurrence and worse overall survival after curative resection. It serves as an independent prognostic factor and improves prediction performance when incorporated into OS/RFS nomograms; its molecular mechanism was not experimentally resolved in this study.	0.6677
38840551	"Cancer communications (London, England)"	2024	Exposure of benzo[a]pyrene induces HCC exosome-circular RNA to activate lung fibroblasts and trigger organotropic metastasis.	hsa_circ_0011496	circ_0011496 / circCSMD2	hsa_circ_CSMD2	CSMD2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"In B[a]P-exposed HCC models, circ_0011496 (circCSMD2) is up-regulated and enriched in tumor-derived exosomes. After delivery to lung fibroblasts, it sponges miR-486-5p, increases TWF1 and downstream MMP9/VEGF signals, promoting CAF-like activation, angiogenesis, and lung-specific metastasis."	0.848
38840772	MedComm	2024	A novel circPIK3C2A/miR_31_5p/TFRC axis drives ferroptosis and accelerates myocardial injury		CircPIK3C2A	rno_circ_PIK3C2A	PIK3C2A	myocardial injury / myocardial damage; iron overload-mediated ferroptosis; myocardial ischemia_reperfusion (I/R) injury	MONDO:0005068; ; 	myocardial infarction	up-regulated	RT-qPCR	"CircPIK3C2A is upregulated under iron overload in cardiomyocytes/heart and promotes ferroptosis. It binds miR-31-5p (sponging/triggering decay), thereby increasing TFRC expression and iron deposition, aggravating myocardial injury."	0.6952
38845955	Heliyon	2024	"CircRNA hsa_circ_0069,399 as a potential clinical prognostic marker in laryngeal squamous cell carcinoma."	hsa_circ_0069399				laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"In LSCC tissues, hsa_circ_0069,399 is up-regulated and was highlighted as a central circRNA in the constructed ceRNA network. It is predicted to compete for hsa-miR-2110_R-1 in axes involving proliferation- and tumor suppressor-related targets (KI67/P53), and is proposed as a potential prognostic marker for LSCC."	0.4032
38845955	Heliyon	2024	"CircRNA hsa_circ_0069,399 as a potential clinical prognostic marker in laryngeal squamous cell carcinoma."		circRNA43			laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circRNA43 is up-regulated in LSCC tissues versus matched para-cancerous tissues and was among the five candidate circRNAs selected from sequencing/bioinformatics results and validated by RT-qPCR, but no specific downstream mechanism was reported for this circRNA."	0.4032
38845955	Heliyon	2024	"CircRNA hsa_circ_0069,399 as a potential clinical prognostic marker in laryngeal squamous cell carcinoma."	hsa_circ_0000344				laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0000344 is down-regulated in LSCC tissues versus matched para-cancerous tissues and was among the candidate circRNAs validated by RT-qPCR; no specific functional mechanism was reported for it in this study.	0.4032
38845955	Heliyon	2024	"CircRNA hsa_circ_0069,399 as a potential clinical prognostic marker in laryngeal squamous cell carcinoma."	hsa_circ_0001725				laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0001725 is down-regulated in LSCC tissues versus matched para-cancerous tissues and was among the candidate circRNAs validated by RT-qPCR; the paper did not report a specific downstream axis for this circRNA.	0.4032
38845955	Heliyon	2024	"CircRNA hsa_circ_0069,399 as a potential clinical prognostic marker in laryngeal squamous cell carcinoma."	hsa_circ_0001789				laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0001789 is down-regulated in LSCC tissues versus matched para-cancerous tissues and was validated by RT-qPCR; this paper did not provide a specific mechanistic axis for it.	0.4032
38848634	"Clinics (Sao Paulo, Brazil)"	2024	CircUBE2D2 regulates HMGB1 through miR-885-5p to promote ovarian cancer malignancy.	hsa_circ_0005728	CircUBE2D2	hsa_circ_UBE2D2	UBE2D2	Ovarian Cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	CircUBE2D2 is up-regulated in ovarian cancer tissues/cells and mainly localizes to the cytoplasm. It promotes malignant phenotypes and tumor growth by sponging miR-885-5p to de-repress HMGB1 (circUBE2D2/miR-885-5p/HMGB1 ceRNA axis). High CircUBE2D2 expression is associated with poorer overall survival in OC patients.	0.8174
38849756	BMC pregnancy and childbirth	2024	CircPAPPA2 plays a role in preeclampsia pathogenesis via regulation of the miR-942/miR-5006-3p.	hsa_circ_0015382	CircPAPPA2	hsa_circ_PAPPA2	PAPPA2	pre-eclampsia / PE	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR; RNA-seq	"circPAPPA2 (hsa_circ_0015382; host gene PAPPA2) is up-regulated in placental tissues from pre-eclampsia patients and has diagnostic potential (AUC 0.8609). Functionally, circPAPPA2 inhibits trophoblast proliferation and invasion, and mechanistically acts as a ceRNA sponge for miR-942-5p and miR-5006-3p, with a proposed downstream link to LEP."	0.7242
38849860	Molecular cancer	2024	Exosomal circSIPA1L3-mediated intercellular communication contributes to glucose metabolic reprogramming and progression of triple negative breast cancer.	hsa_circ_0005081	circSIPA1L3	hsa_circ_SIPA1L3	SIPA1L3	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; RNA-seq	"circSIPA1L3 is up-regulated in breast cancer (including TNBC) and can be transported via exosomes to enhance malignant phenotypes. It promotes glycolysis and stemness by stabilizing IGF2BP3 through USP7-mediated deubiquitination and by regulating SLC16A1/RAB11A via IGF2BP3-dependent mRNA stabilization and miR-665 sponging, and high circSIPA1L3 predicts poor prognosis and shows serum diagnostic value."	0.9026
38858365	Nature communications	2024	Identification and characterization of Varicella Zoster Virus circular RNA in lytic infection.		circVLTslytic	vzc_circ_VLTs		Varicella-Zoster Virus lytic infection / VZV infection	MONDO:0005608	varicella zoster infection	dysregulated	RT-qPCR; ISH; RNA-seq	"circVLTslytic is a VZV-derived circRNA originating from VLTs/VLTs-like transcripts. Its biogenesis depends on cis-elements flanking the 5¡¯ splice donor, and disrupting this region increases VZV sensitivity to acyclovir; overexpressing circVLT isoforms alleviates the antiviral effect of acyclovir and supports viral replication under drug pressure."	0.7311
38861540	PloS one	2024	Identification of exosomal circSLC26A4 as a liquid biopsy marker for cervical cancer.		circSLC26A4 / Circular RNA SLC26A4	hsa_circ_SLC26A4	SLC26A4	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	This study shows that exosomal circSLC26A4 is up-regulated in cervical cancer cell line-derived exosomes and in plasma exosomes from CC patients. Plasma exosomal circSLC26A4 demonstrates strong diagnostic potential (ROC analysis) and its higher levels are associated with lymph node metastasis and higher FIGO stage.	0.4187
38862985	Cell division	2024	Extracellular vesicle-delivered hsa_circ_0090081 regulated by EIF4A3 enhances gastric cancer tumorigenesis.	hsa_circ_0090081		hsa_circ_PHEX	PHEX	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0090081 is up-regulated in gastric cancer and promotes proliferation, migration and invasion of GC cells. EIF4A3 binds PHEX pre-mRNA and increases hsa_circ_0090081 expression, and GC cell-derived extracellular vesicles deliver hsa_circ_0090081 to recipient cells to enhance tumorigenic phenotypes. High hsa_circ_0090081 expression is associated with poorer patient survival."	0.7941
38866787	Cell death & disease	2024	Human gastric cancer progression and stabilization of ATG2B through RNF5 binding facilitated by autophagy-associated CircDHX8.	hsa_circ_0003899	circDHX8	hsa_circ_DHX8	DHX8	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq; Microarray	"circDHX8 (hsa_circ_0003899) is up-regulated in gastric cancer tissues/cell lines and promotes malignant phenotypes (proliferation, migration/invasion, tumor growth) while inhibiting apoptosis. Mechanistically, it binds RNF5 to block RNF5-mediated ubiquitination/degradation of ATG2B, stabilizing ATG2B and enhancing autophagy. High circDHX8 expression correlates with advanced disease and poor prognosis."	0.8491
38866807	Scientific reports	2024	CircZNF609 and circNFIX as possible regulators of glioblastoma pathogenesis via miR-145-5p/EGFR axis.	hsa_circ_0000615	circZNF609 / circ0000615	hsa_circ_ZNF609	ZNF609	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR	"circZNF609 (hsa_circ_0000615, from ZNF609) is significantly upregulated in glioblastoma tissues versus normal brain. The study proposes a ceRNA model in which circZNF609 sponges miR-145-5p, consistent with inverse correlation to miR-145-5p and positive correlation with EGFR, suggesting potential involvement in GBM pathogenesis and diagnostic discrimination."	0.6238
38866992	Clinical rheumatology	2024	The circular RNA hsa_circ_0045800 serves as a favorable biomarker in pathogenesis of sj_gren's syndrome.	hsa_circ_0045800	circ_0045800 / circURE2O	hsa_circ_UBE2O	UBE2O	primary Sj_gren's syndrome / pSS	MONDO:0019347	peeling skin syndrome	up-regulated	RT-qPCR	"hsa_circ_0045800 is up-regulated in PBMCs from primary Sj_gren's syndrome patients and correlates with disease activity. It promotes pSS progression by sponging miR-1247-5p and thereby regulating SMAD2, implicating activation of the TGF-beta/SMAD pathway. It shows diagnostic value (ROC AUC 0.865) and decreases after treatment, supporting use as a biomarker for diagnosis and treatment monitoring."	0.6303
38877514	BMC cancer	2024	METTL3-induced circ_0008345 contributes to the progression of colorectal cancer via the microRNA-182-5p/CYP1A2 pathway.	hsa_circ_0008345	circ_0008345	hsa_circ_PTK2	PTK2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0008345 is up-regulated in colorectal cancer and mainly localized in the cytoplasm. It promotes CRC proliferation, migration/invasion and xenograft tumor growth by acting as a ceRNA that sponges miR-182-5p to increase CYP1A2. METTL3-mediated m6A modification enhances circ_0008345 expression/stability, reinforcing this axis."	0.8267
38878321	"Clinics (Sao Paulo, Brazil)"	2024	Circ-USP9X accelerates deep vein thrombosis after fracture by acting as a miR-148b-3p sponge and upregulates SRC kinase signaling inhibitor 1.	hsa_circ_0090221	circUSP9X / Circular RNA Ubiquitin Specific Peptidase 9 X-Linked	hsa_circ_USP9X	USP9X	Deep Vein Thrombosis / DVT	MONDO:0005399	venous thromboembolism	up-regulated	RT-qPCR	"circUSP9X is up-regulated in DVT patient blood and in DVT models. It promotes endothelial injury and DVT formation by sponging miR-148b-3p to de-repress SRCIN1, increasing apoptosis and inflammatory signaling; circUSP9X knockdown reduces thrombus formation in mice."	0.7949
38880872	BMC cardiovascular disorders	2024	Identification and verification of circRNA biomarkers for coronary artery disease based on WGCNA and the LASSO algorithm.	hsa_circ_0069972		hsa_circ_CXCL5	CXCL5	coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR; Microarray	"hsa_circ_0069972 is up-regulated in peripheral blood of CAD patients and remains independently associated with CAD after adjustment for confounders, showing diagnostic value (AUC 0.760). Bioinformatic prediction suggests it may act through a circRNA-miRNA-mRNA network enriched in TGF-beta, FoxO and Hippo-related signaling."	0.5534
38880872	BMC cardiovascular disorders	2024	Identification and verification of circRNA biomarkers for coronary artery disease based on WGCNA and the LASSO algorithm.	hsa_circ_0021509		hsa_circ_ANO5	ANO5	coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR; Microarray	"hsa_circ_0021509 is up-regulated in peripheral blood of CAD patients and independently associated with CAD, with diagnostic performance (AUC 0.717). Bioinformatic prediction indicates a circRNA-miRNA-mRNA network enriched in PI3K/Akt and MAPK-related signaling."	0.5534
38880872	BMC cardiovascular disorders	2024	Identification and verification of circRNA biomarkers for coronary artery disease based on WGCNA and the LASSO algorithm.	hsa_circ_0031891				coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR	"hsa_circ_0031891 is significantly up-regulated in CAD patient blood by RT-qPCR, with direction consistent with microarray results, but it is not an independent predictor in multivariable logistic regression. Statin use is associated with higher hsa_circ_0031891 levels among CAD patients."	0.2995
38882353	Heliyon	2024	CircACTR2 promotes bladder cancer progression through IKBKB-mediated NF-kappaB signaling pathway activation.	hsa_circ_0008529	circACTR2 / hsa_circRNA_102747	hsa_circ_ACTR2	ACTR2	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circACTR2 is upregulated in bladder cancer tissues/cell lines and functions as an oncogenic circRNA. It sponges miR-219a-2-3p to increase IKBKB (IKKbeta), promoting p65 nuclear translocation and activating NF-kappaB signaling, thereby enhancing proliferation, migration, and invasion of BCa cells."	0.849
38887684	Journal of hepatocellular carcinoma	2024	Circ_0007386 Promotes the Progression of Hepatocellular Carcinoma Through the miR-507/ CCNT2 Axis.	hsa_circ_0007386	circ_0007386 / circ0007386	hsa_circ_CRIM1	CRIM1	Hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0007386 (CRIM1-derived) is upregulated in HCC and mainly localized in the cytoplasm. It promotes proliferation, migration/invasion, EMT and in vivo tumor growth/metastasis by sponging miR-507 and derepressing CCNT2, and it also contributes to lenvatinib resistance; high expression predicts poor survival."	0.8832
38890620	Molecular cancer	2024	Circ6834 suppresses non-small cell lung cancer progression by destabilizing ANHAK and regulating miR-873-5p/TXNIP axis.	hsa_circ_0006834	circ6834	hsa_circ_EPB41L5	EPB41L5	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	"Circ6834 (hsa_circ_0006834), derived from EPB41L5, is down-regulated in NSCLC and functions as a tumor suppressor. It inhibits proliferation, EMT, migration/invasion and metastasis by promoting TRIM25-dependent ubiquitination/degradation of AHNAK and by sponging miR-873-5p to upregulate TXNIP, thereby dampening TGF-beta/Smad signaling; it also increases sensitivity to cisplatin/oxaliplatin."	0.8933
38902782	Journal of translational medicine	2024	Circ_0004851 regulates the molecular mechanism of miR-296-3p/FGF11 in the influence of high iodine on PTC.	hsa_circ_0004851	circ_0004851	hsa_circ_CAPRIN1	CAPRIN1	papillary thyroid cancer / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ_0004851 is up-regulated in high-iodine PTC and mainly localizes to the cytoplasm. It promotes PTC malignant phenotypes by acting as a ceRNA sponge for miR-296-3p, thereby relieving repression of FGF11 and enhancing proliferation/migration/invasion while inhibiting apoptosis, including in a BCPAP-derived xenograft model under high iodine exposure."	0.7534
38907258	Thrombosis journal	2024	Platelet-derived circFAM13B associated with anti-platelet responsiveness of ticagrelor in patients with acute coronary syndrome.	hsa_circ_0001535	circFAM13B	hsa_circ_FAM13B	FAM13B	acute coronary syndrome / ACS	MONDO:0005542	acute coronary syndrome	dysregulated	RT-qPCR	"In ticagrelor-treated ACS patients, platelet-derived circFAM13B level is associated with antiplatelet responsiveness (HTPR) and independently predicts adverse ischemic events during follow-up. A miR-126/P2Y12-related mechanism is proposed only by bioinformatics prediction and hypothesis, without experimental validation."	0.4992
38907517	Cancer biology & medicine	2024	Amplifying colorectal cancer progression: impact of a PDIA4/SP1 positive feedback loop by circPDIA4 sponging miR-9-5p.		circPDIA4	hsa_circ_PDIA4	PDIA4	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circPDIA4 is up-regulated in colorectal cancer tissues and cell lines and promotes CRC proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, it mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-9-5p to de-repress SP1, while SP1 transcriptionally enhances PDIA4/circPDIA4, forming a positive feedback loop that aggravates CRC progression."	0.8455
38909325	Cellular and molecular life sciences : CMLS	2024	WTAP and m6A-modified circRNAs modulation during stress response in acute myeloid leukemia progenitor cells.		circHIPK3	hsa_circ_HIPK3	HIPK3	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; RNA-seq	"In MOLM-13 AML cells, bortezomib-induced oxidative stress increases m6A methylation and expression of circHIPK3. circHIPK3 knockdown elevates ROS and exacerbates ER stress/misfolded protein accumulation, indicating a protective role in oxidative and ER stress adaptation."	0.6772
38909325	Cellular and molecular life sciences : CMLS	2024	WTAP and m6A-modified circRNAs modulation during stress response in acute myeloid leukemia progenitor cells.		circZNF609	hsa_circ_ZNF609	ZNF609	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; RNA-seq	"circZNF609 is a bortezomib-inducible, m6A-hypermethylated circRNA in AML cells, and its induction is blocked by antioxidant NAC, linking its upregulation to oxidative stress during proteotoxic stress response."	0.4276
38909325	Cellular and molecular life sciences : CMLS	2024	WTAP and m6A-modified circRNAs modulation during stress response in acute myeloid leukemia progenitor cells.		circRNF220	hsa_circ_RNF220	RNF220	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; RNA-seq	"circRNF220 is hypermethylated (m6A) and upregulated after bortezomib-induced stress in AML cells, and its induction is blocked by NAC, supporting an oxidative-stress-dependent regulation."	0.4276
38909325	Cellular and molecular life sciences : CMLS	2024	WTAP and m6A-modified circRNAs modulation during stress response in acute myeloid leukemia progenitor cells.		circAFF1	hsa_circ_AFF1	AFF1	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; RNA-seq	"circAFF1 is hypermethylated (m6A) and upregulated after bortezomib treatment in AML cells, and NAC blocks the bortezomib-induced increase, suggesting oxidative-stress-dependent regulation during stress response."	0.4276
38910902	Oncology letters	2024	Hsa_circ_0064636 regulates voltage dependent anion channel 1/ubiquitination factor E4A through miR_326/miR_503_5 in osteosarcoma.	hsa_circ_0064636				osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"hsa_circ_0064636 is up-regulated in osteosarcoma cell lines. The study proposes a ceRNA sub-network in which hsa_circ_0064636 sponges miR-326 and miR-503-5p to regulate UBE4A and VDAC1, respectively, and highlights prognostic relevance through downstream target-gene survival analyses."	0.329
38913848	Epigenetics	2024	YY1/circCTNNB1/miR-186-5p/YY1 positive loop aggravates lung cancer progression through the Wnt pathway.		circCTNNB1 / circ-CTNNB1	hsa_circ_CTNNB1	CTNNB1	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circCTNNB1 is up-regulated in lung cancer and associated with poor prognosis. It promotes proliferation, migration and invasion while suppressing senescence, and enhances tumor growth in vivo. Mechanistically, circCTNNB1 sponges miR-186-5p to increase YY1, and YY1 transcriptionally activates circCTNNB1, forming a positive feedback loop that activates the Wnt/beta-catenin pathway."	0.8586
38914806	Journal of cancer research and clinical oncology	2024	Circular RNA circLIFR suppresses papillary thyroid cancer progression by modulating the miR-429/TIMP2 axis.	hsa_circ_0072309	circLIFR / circLIF receptor subunit alpha (LIFR)	hsa_circ_LIFR	LIFR	papillary thyroid cancer / PTC	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR; RNA-seq	"circLIFR (hsa_circ_0072309), derived from LIFR, is down-regulated in papillary thyroid cancer and acts as a tumor suppressor by inhibiting proliferation and migration. It functions as a miR-429 sponge to relieve repression of TIMP2, and circLIFR overexpression suppresses xenograft tumor growth."	0.866
38915053	Journal of translational medicine	2024	circSORBS1 inhibits lung cancer progression by sponging miR-6779-5p and directly binding RUFY3 mRNA.		circSORBS1	hsa_circ_SORBS1	SORBS1	lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR; RNA-seq	"circSORBS1 is down-regulated in lung cancer tissues/plasma/cell lines and functions as a tumor suppressor. It sponges miR-6779-5p and also directly binds RUFY3 mRNA to increase its stability, raising RUFY3 protein and modulating the YWHAE/BAD/BCL2 apoptotic signaling to promote apoptosis and inhibit proliferation/migration and tumor growth."	0.8981
38918678	Asian Pacific journal of cancer prevention : APJCP	2024	Identification of Circular RNAs as Biomarker Candidates in Lung Cancer Treatment.	hsa_circ_0001320		hsa_circ_FOXP1	FOXP1	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"In A549 NSCLC cells, hsa_circ_0001320 is absent without treatment but becomes induced after carboplatin and/or pemetrexed, with a synergistic increase under combination therapy. The study proposes it as a candidate biomarker for monitoring chemotherapy response; bioinformatics analyses further suggest pathway involvement (e.g., PI3K-AKT/FOXO) without defining a direct mechanistic axis."	0.329
38918678	Asian Pacific journal of cancer prevention : APJCP	2024	Identification of Circular RNAs as Biomarker Candidates in Lung Cancer Treatment.	hsa_circ_0002130		hsa_circ_C3	C3	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"hsa_circ_0002130 is expressed in A549 cells and is significantly induced by carboplatin and by carboplatin+pemetrexed combination, indicating association with treatment response in this in vitro lung cancer model."	0.279
38918678	Asian Pacific journal of cancer prevention : APJCP	2024	Identification of Circular RNAs as Biomarker Candidates in Lung Cancer Treatment.	hsa_circ_0001346	circRNF13	hsa_circ_RNF13	RNF13	lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	"hsa_circ_0001346 (circRNF13) is expressed in A549 cells and is significantly reduced after carboplatin and combination treatment, indicating drug-responsive downregulation in this lung cancer cell model. The paper discusses prior reports linking it to miR-93-5p binding and chemoresistance, but does not experimentally validate that mechanism here."	0.279
38918678	Asian Pacific journal of cancer prevention : APJCP	2024	Identification of Circular RNAs as Biomarker Candidates in Lung Cancer Treatment.	hsa_circ_0077837		hsa_circ_EPB41L2	EPB41L2	lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	"hsa_circ_0077837 is not detected in untreated A549 cells but becomes expressed after chemotherapy exposure; its expression decreases under combined carboplatin+pemetrexed treatment, indicating a treatment-dependent response pattern."	0.279
38918678	Asian Pacific journal of cancer prevention : APJCP	2024	Identification of Circular RNAs as Biomarker Candidates in Lung Cancer Treatment.	hsa_circ_0000003		hsa_circ_ATAD3B	ATAD3B	lung cancer	MONDO:0008903	lung cancer	unknown	RT-qPCR	"hsa_circ_0000003 is not detected in untreated A549 cells but is detectable after each drug exposure condition, suggesting it is treatment-inducible; the study does not report the directionality between different treatment groups for this circRNA."	0.279
38918678	Asian Pacific journal of cancer prevention : APJCP	2024	Identification of Circular RNAs as Biomarker Candidates in Lung Cancer Treatment.	hsa_circ_0087862		hsa_circ_RAD23B	RAD23B	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"hsa_circ_0087862 is induced by carboplatin and pemetrexed treatments in A549 cells and shows a synergistic increase under combination therapy, consistent with a drug-response associated expression change."	0.279
38918678	Asian Pacific journal of cancer prevention : APJCP	2024	Identification of Circular RNAs as Biomarker Candidates in Lung Cancer Treatment.	hsa_circ_0001492		hsa_circ_ERBB2IP	ERBB2IP	lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	"hsa_circ_0001492 is detectable after single-agent carboplatin or pemetrexed but becomes undetectable after the combined regimen, suggesting the combination suppresses its expression in A549 lung cancer cells."	0.279
38918678	Asian Pacific journal of cancer prevention : APJCP	2024	Identification of Circular RNAs as Biomarker Candidates in Lung Cancer Treatment.	hsa_circ_0008193		hsa_circ_FAM120A	FAM120A	lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	"hsa_circ_0008193 is expressed following single-agent treatment but is completely suppressed by combined carboplatin+pemetrexed in A549 cells, suggesting a combination-specific inhibitory effect on its expression."	0.279
38918678	Asian Pacific journal of cancer prevention : APJCP	2024	Identification of Circular RNAs as Biomarker Candidates in Lung Cancer Treatment.	hsa_circ_0000064		hsa_circ_B4GALT2	B4GALT2	lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	"hsa_circ_0000064 is present after single-agent chemotherapy but disappears under combined therapy in A549 cells, indicating combination-associated suppression."	0.279
38918678	Asian Pacific journal of cancer prevention : APJCP	2024	Identification of Circular RNAs as Biomarker Candidates in Lung Cancer Treatment.	hsa_circ_0014235		hsa_circ_S100A2	S100A2	lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	This study reports that the circRNA referred to as hsa_circ_00014235 (listed as hsa_circ_0014235 in the characteristics table) is detectable after either carboplatin or pemetrexed alone but is completely inhibited by combination treatment in A549 cells.	0.279
38918678	Asian Pacific journal of cancer prevention : APJCP	2024	Identification of Circular RNAs as Biomarker Candidates in Lung Cancer Treatment.	hsa_circ_0072309		hsa_circ_LIFR	LIFR	lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	The study reports that the circRNA referred to as hsa_circ_00072309 (listed as hsa_circ_0072309 in the characteristics table) becomes completely inhibited after pemetrexed exposure in A549 lung cancer cells.	0.279
38918678	Asian Pacific journal of cancer prevention : APJCP	2024	Identification of Circular RNAs as Biomarker Candidates in Lung Cancer Treatment.	hsa_circ_0067934		hsa_circ_PRKCI	PRKCI	lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	"hsa_circ_0067934 is reported to be completely suppressed by pemetrexed in A549 lung cancer cells, indicating a strong treatment-associated downregulation (loss of detectable expression)."	0.279
38918678	Asian Pacific journal of cancer prevention : APJCP	2024	Identification of Circular RNAs as Biomarker Candidates in Lung Cancer Treatment.	hsa_circ_0008274		hsa_circ_UGGT2	UGGT2	lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	"hsa_circ_0008274 is completely inhibited by pemetrexed treatment in A549 lung cancer cells, indicating drug-associated loss of expression."	0.279
38918678	Asian Pacific journal of cancer prevention : APJCP	2024	Identification of Circular RNAs as Biomarker Candidates in Lung Cancer Treatment.	hsa_circ_0022812		hsa_circ_POLA2	POLA2	lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	hsa_circ_0022812 is reported as a circRNA whose expression is completely inhibited by pemetrexed in A549 lung cancer cells.	0.279
38918678	Asian Pacific journal of cancer prevention : APJCP	2024	Identification of Circular RNAs as Biomarker Candidates in Lung Cancer Treatment.	hsa_circ_0003998		hsa_circ_ARFGEF2	ARFGEF2	lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	"hsa_circ_0003998 expression is inhibited by carboplatin in A549 lung cancer cells, suggesting it is downregulated upon platinum exposure in this model."	0.279
38918678	Asian Pacific journal of cancer prevention : APJCP	2024	Identification of Circular RNAs as Biomarker Candidates in Lung Cancer Treatment.	hsa_circ_0049657		hsa_circ_NFIX	NFIX	lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	The circRNA mentioned as hsa_circ_00049657 (listed as hsa_circ_0049657 in the characteristics table) is inhibited by carboplatin in A549 lung cancer cells.	0.279
38918678	Asian Pacific journal of cancer prevention : APJCP	2024	Identification of Circular RNAs as Biomarker Candidates in Lung Cancer Treatment.	hsa_circ_0018818		hsa_circ_USP54	USP54	lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	"hsa_circ_0018818 is inhibited by carboplatin in A549 lung cancer cells, indicating downregulation in response to this drug."	0.279
38918678	Asian Pacific journal of cancer prevention : APJCP	2024	Identification of Circular RNAs as Biomarker Candidates in Lung Cancer Treatment.	hsa_circ_0000043		hsa_circ_PUM1	PUM1	lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	"hsa_circ_0000043 is inhibited by carboplatin in A549 lung cancer cells, indicating drug-associated downregulation in this in vitro model."	0.279
38918678	Asian Pacific journal of cancer prevention : APJCP	2024	Identification of Circular RNAs as Biomarker Candidates in Lung Cancer Treatment.	hsa_circ_0102533		hsa_circ_PCNX	PCNX	lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	"hsa_circ_0102533 is reduced by carboplatin and by pemetrexed, and becomes undetectable with combined treatment in A549 cells, supporting its potential use as a treatment follow-up biomarker in this in vitro lung cancer setting."	0.279
38918678	Asian Pacific journal of cancer prevention : APJCP	2024	Identification of Circular RNAs as Biomarker Candidates in Lung Cancer Treatment.	hsa_circ_0008305		hsa_circ_PTK2	PTK2	lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	"hsa_circ_0008305 decreases with either carboplatin or pemetrexed and becomes undetectable after combined therapy in A549 cells, supporting its candidacy as a treatment follow-up biomarker in this experimental model."	0.279
38918678	Asian Pacific journal of cancer prevention : APJCP	2024	Identification of Circular RNAs as Biomarker Candidates in Lung Cancer Treatment.	hsa_circ_0001875		hsa_circ_FAM120A	FAM120A	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"hsa_circ_0001875 increases in response to single-agent chemotherapy in A549 cells, with a statistically significant increase under carboplatin, suggesting it is induced by platinum treatment in this model."	0.279
38918678	Asian Pacific journal of cancer prevention : APJCP	2024	Identification of Circular RNAs as Biomarker Candidates in Lung Cancer Treatment.	hsa_circ_0007385		hsa_circ_MEMO1	MEMO1	lung cancer	MONDO:0008903	lung cancer	dysregulated	RT-qPCR	hsa_circ_0007385 shows opposite responses depending on regimen: it increases after carboplatin alone but is completely inhibited by combined carboplatin+pemetrexed in A549 cells. The authors suggest this pattern may relate to platinum-based drug resistance.	0.279
38918678	Asian Pacific journal of cancer prevention : APJCP	2024	Identification of Circular RNAs as Biomarker Candidates in Lung Cancer Treatment.	hsa_circ_0060937		hsa_circ_CYP24A1	CYP24A1	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"hsa_circ_0060937 is selectively induced by pemetrexed (but not reported as induced by carboplatin or combination) in A549 lung cancer cells, indicating a drug-specific upregulation pattern in this model."	0.279
38918838	Journal of nanobiotechnology	2024	M6A demethylase FTO-stabilized exosomal circBRCA1 alleviates oxidative stress-induced granulosa cell damage via the miR-642a-5p/FOXO1 axis.	hsa_circ_0043949	circBRCA1	hsa_circ_BRCA1	BRCA1	Premature ovarian insufficiency / POI	MONDO:0005387	primary ovarian failure	down-regulated	RT-qPCR	"circBRCA1 (hsa_circ_0043949), derived from BRCA1 and enriched in HucMSC exosomes, is down-regulated in serum and granulosa cells of POI patients. Exosomal circBRCA1 alleviates oxidative stress-induced granulosa cell mitochondrial dysfunction and senescence by acting as a ceRNA that sponges miR-642a-5p, thereby upregulating FOXO1; its stability/expression is enhanced by FTO-mediated m6A demethylation. Clinically, circBRCA1 correlates with ovarian reserve indicators and is proposed as a potential biomarker/therapeutic target for POI."	0.8435
38920665	Cells	2024	Small Extracellular Vesicle-Derived Circular RNA hsa_circ_0007386 as a Biomarker for the Diagnosis of Pleural Mesothelioma.	hsa_circ_0007386		hsa_circ_PHKB	PHKB	Pleural mesothelioma / PM	MONDO:0003308	pleural mesothelioma	up-regulated	RT-qPCR	"hsa_circ_0007386 (PHKB-derived) is up-regulated in pleural mesothelioma cell lines and their small extracellular vesicles, and is proposed as a diagnostic biomarker with reported sensitivity/specificity based on cell-line and sEV measurements by digital PCR."	0.2586
38924205	Journal of cellular and molecular medicine	2024	Resistance to gemcitabine is mediated by the circ_0036627/miR-145/S100A16 axis in pancreatic cancer.	hsa_circ_0036627	circ_0036627	hsa_circ_PDE8A	PDE8A	pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"circ_0036627 is up-regulated in pancreatic cancer tissues/cell lines and promotes malignant phenotypes and gemcitabine resistance. Mechanistically, it functions as a miRNA sponge for miR-145, thereby increasing S100A16 expression and contributing to chemoresistance. High circ_0036627 expression is associated with higher tumor grade and poor overall survival."	0.8174
38926642	BMC genomics	2024	Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics.		circ_0002743			aging			dysregulated	RT-qPCR; RNA-seq	"circ_0002743 is an age-associated differentially expressed circRNA in rhesus macaque blood, and its expression change is consistent between blood and brain, suggesting potential as a blood-based biomarker for detecting brain aging."	0.4625
38926642	BMC genomics	2024	Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics.		circ_0005016			aging			dysregulated	RT-qPCR; RNA-seq	"circ_0005016 is an age-associated differentially expressed circRNA in rhesus macaque blood, and its expression change is consistent between blood and brain, supporting its potential as a blood-based biomarker for detecting brain aging."	0.4625
38926642	BMC genomics	2024	Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics.		circ_0010527			aging			dysregulated	RT-qPCR; RNA-seq	"circ_0010527 is an age-associated differentially expressed circRNA in rhesus macaque blood, with consistent expression changes in brain, indicating potential utility as a blood marker for brain aging."	0.4625
38926642	BMC genomics	2024	Analysis of the aging-related biomarker in a nonhuman primate model using multilayer omics.		circ_0008814			aging 			dysregulated	RT-qPCR; RNA-seq	"circ_0008814 is an age-associated differentially expressed circRNA in rhesus macaque blood, and its change is consistent in brain, supporting its candidacy as a blood biomarker for brain aging."	0.4625
38926729	"Radiation oncology (London, England)"	2024	CircRNA_101491 regulated the radiation sensitivity of esophageal squamous cell carcinomas via sponging miR-125a-5p.		CircRNA_101491 / Circ101491	hsa_circ_MAPKBP1	MAPKBP1	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"CircRNA_101491 is up-regulated in radioresistant ESCC KYSE150R cells and promotes radioresistance. Its knockdown increases radiosensitivity by releasing miR-125a-5p, reversing EMT and enhancing apoptosis, and this effect is supported by both in vitro assays and KYSE150R xenograft experiments."	0.6119
38926764	Journal of translational medicine	2024	Exploring the oncogenic potential of circSOD2 in clear cell renal cell carcinoma: a novel positive feedback loop.	hsa_circ_0004662	circSOD2 / hsa_circRNA_004662	hsa_circ_SOD2	SOD2	clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR; Microarray	"circSOD2 is up-regulated in ccRCC and promotes malignant phenotypes (proliferation, invasion/migration, metastasis) while inhibiting apoptosis. Mechanistically, circSOD2 sponges miR-532-3p to relieve repression of PAX5, and PAX5 transcriptionally enhances circSOD2 biogenesis, forming a positive feedback loop and associated PI3K/AKT/mTOR activation. High circSOD2 expression correlates with advanced stage/grade and poorer OS/DFS."	0.8988
38927017	Biomolecules	2024	CircInpp5b Ameliorates Renal Interstitial Fibrosis by Promoting the Lysosomal Degradation of DDX1.		cirInpp5b / circInpp5b	mmu_circ_Inpp5b	Inpp5b	renal interstitial fibrosis / RIF	MONDO:0002771	pulmonary fibrosis	down-regulated	RT-qPCR; RNA-seq	"circInpp5b is down-regulated in UUO-induced renal interstitial fibrosis and in TGF-beta1-treated renal tubular cells. circInpp5b overexpression alleviates fibrosis/ECM deposition by binding DDX1 and promoting its lysosomal degradation, thereby lowering DDX1 protein levels."	0.673
38933922	Frontiers in genetics	2024	Construction of a ceRNA network and screening of potential biomarkers and molecular targets in male smokers with chronic obstructive pulmonary disease.		hsa_circ_006155			chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_006155 is up-regulated in PBMCs from male smokers with COPD compared with healthy controls, supported by RNA-seq and validated by RT-qPCR."	0.4032
38933922	Frontiers in genetics	2024	Construction of a ceRNA network and screening of potential biomarkers and molecular targets in male smokers with chronic obstructive pulmonary disease.		hsa_circ_031080			chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_031080 is up-regulated in PBMCs from male smokers with COPD compared with healthy controls, supported by RNA-seq and validated by RT-qPCR."	0.4032
38933922	Frontiers in genetics	2024	Construction of a ceRNA network and screening of potential biomarkers and molecular targets in male smokers with chronic obstructive pulmonary disease.		hsa_circ_041434			chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_041434 is up-regulated in PBMCs from male smokers with COPD compared with healthy controls, supported by RNA-seq and validated by RT-qPCR."	0.4032
38933922	Frontiers in genetics	2024	Construction of a ceRNA network and screening of potential biomarkers and molecular targets in male smokers with chronic obstructive pulmonary disease.		hsa_circ_007446			chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_007446 is down-regulated in PBMCs from male smokers with COPD compared with healthy controls, supported by RNA-seq and validated by RT-qPCR."	0.4032
38933922	Frontiers in genetics	2024	Construction of a ceRNA network and screening of potential biomarkers and molecular targets in male smokers with chronic obstructive pulmonary disease.		hsa_circ_019015			chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_019015 is down-regulated in PBMCs from male smokers with COPD compared with healthy controls, supported by RNA-seq and validated by RT-qPCR."	0.4032
38933922	Frontiers in genetics	2024	Construction of a ceRNA network and screening of potential biomarkers and molecular targets in male smokers with chronic obstructive pulmonary disease.		hsa_circ_038146			chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_038146 is down-regulated in PBMCs from male smokers with COPD compared with healthy controls, supported by RNA-seq and validated by RT-qPCR."	0.4032
38936216	Poultry science	2024	Exosomal circ_CCDC7/gga-miR-6568-3p/Pax7 axis accelerates the differentiation of chicken embryonic stem cells infected with subgroup J avian leukosis virus.		circ_CCDC7 / Circ-CCDC7	gga_circ_CCDC7	CCDC7	ALV-J infection	MONDO:0005108	viral infectious disease	up-regulated	RT-qPCR; RNA-seq	"circ_CCDC7 is up-regulated in exosomes from ALV-J-infected chicken embryonic stem cells and promotes/accelerates their differentiation. The study proposes a circ_CCDC7_gga-miR-6568-3p_Pax7 regulatory axis in which circ_CCDC7 targets gga-miR-6568-3p, thereby relieving inhibition on Pax7."	0.4375
38937788	Breast cancer research : BCR	2024	Circular RNA HSDL2 promotes breast cancer progression via miR-7978 ZNF704 axis and regulating hippo signaling pathway.	hsa_circ_0088088	circHSDL2 / circ-0088088	hsa_circ_HSDL2	HSDL2	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq; Microarray	"circHSDL2 is up-regulated in breast cancer and promotes proliferation, migration, invasion and metastasis. It functions as a ceRNA by sponging miR-7978 to increase ZNF704, leading to dysregulation/activation of Hippo/YAP signaling (including reduced MST2 and increased downstream phosphorylation markers)."	0.7577
38941402	Medicine	2024	Construction of the circRNA-miRNA-mRNA axis based on ferroptosis-related gene AKR1C1 to explore the potential pathogenesis of abdominal aortic aneurysm.	hsa_circ_0005073				abdominal aortic aneurysm / AAA	MONDO:0005350	abdominal aortic aneurysm	down-regulated	Microarray	has_circ_0005073 is down-regulated in AAA (validated in an external GEO dataset) and was proposed to participate in AAA pathogenesis via a ceRNA axis with miRNA-543 regulating AKR1C1.	0.1768
38945954	Experimental & molecular medicine	2024	Noncoding RNA regulates the expression of Krm1 and Dkk2 to synergistically affect aortic valve lesions.	hsa_circ_0000284	circHIPK3	hsa_circ_HIPK3	HIPK3	Calcific aortic valve disease / CAVD	MONDO:0005463	aortic valve calcification	down-regulated	RT-qPCR; ISH; RNA-seq	"circHIPK3 is down-regulated in calcified human aortic valves. Functionally, increasing circHIPK3 suppresses AVIC osteogenic differentiation and alleviates valve calcification in mouse CAVD models. Mechanistically, DDX5 recruits METTL3 to install m6A on circHIPK3, enabling circHIPK3 to scaffold IGF2BP2 and stabilize Krm1 mRNA, thereby inhibiting Wnt/beta-catenin signaling."	0.8254
38947400	Journal of Cancer	2024	Acting mechanism and clinical significance of hsa_circ_0005927 in the invasion and metastasis of gastric cancer.	hsa_circ_0005927		hsa_circ_VDAC3	VDAC3	gastric cancer / GC	MONDO:0001056	gastric cancer	dysregulated	RT-qPCR	"hsa_circ_0005927 shows abnormal expression in gastric carcinogenesis: it is decreased in HGIEN/GC tissues but increased in plasma of early GC patients. Functional assays indicate it promotes GC cell proliferation, migration, and invasion, and it is predicted to act as a cytoplasmic miRNA sponge (ceRNA) interacting with five miRNAs and affecting hundreds of downstream genes, with potential utility as an early screening and prognostic biomarker."	0.7623
38956466	Cellular & molecular biology letters	2024	"RUNX1, FUS, and ELAVL1-induced circPTPN22 promote gastric cancer cell proliferation, migration, and invasion through miR-6788-5p/PAK1 axis-mediated autophagy."		circPTPN22	hsa_circ_PTPN22	PTPN22	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"In gastric cancer, circPTPN22 is up-regulated and promotes proliferation, migration, invasion, and in vivo tumor growth while inhibiting autophagy. It mainly functions as a ceRNA by sponging miR-6788-5p to upregulate PAK1, activating Akt and Erk phosphorylation to suppress autophagy. circPTPN22 biogenesis is negatively regulated by RUNX1 and positively regulated by RBPs FUS and ELAVL1, and autophagy inhibition forms a positive feedback loop via increased FUS that further elevates circPTPN22."	0.8109
38957564	Annals of gastroenterological surgery	2024	Overexpression of circular RNA hsa_circ_0008621 facilitates colorectal cancer progression and predicts poor prognosis.	hsa_circ_0008621	hsa_circHMGCS1_016 / circHMGCS1-016	hsa_circ_HMGCS1	HMGCS1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"hsa_circ_0008621 is up-regulated in CRC tissues and serum and serves as a prognostic biomarker, where higher serum levels predict worse OS and RFS. Functionally, it promotes CRC cell proliferation, migration, invasion and glycolysis while inhibiting apoptosis, at least in part via a ceRNA mechanism sponging miR-532-5p to regulate SLC16A3."	0.7713
38966668	Journal of immunology research	2024	Circular RNA CircZNF644 Facilitates Circulating Follicular Helper T Cells Response in Patients with Graves' Disease.	hsa_circ_0114427	circZNF644	hsa_circ_ZNF644	ZNF644	Graves' disease / GD	MONDO:0005364	Graves disease	up-regulated	RT-qPCR; RNA-seq	"circZNF644 is up-regulated in PBMCs from Graves' disease patients and acts in the cytoplasm as a ceRNA for miR-29a-3p. By relieving miR-29a-3p repression, circZNF644 increases ICOS expression, which elevates cTfh cell proportion and promotes IL-21 expression; circZNF644 levels correlate positively with TRAb."	0.8012
38967046	Bioscience reports	2024	Functional analysis of a panel of molecular markers for diagnosis of systemic lupus erythematosus in rats.	rno_circ_0044897	circ-0044897	rno_circ_TubD1	TubD1	systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	down-regulated	RT-qPCR	"circ-TubD1 is down-regulated in serum of SLE-induced rats and shows a negative correlation with rno-miR-146a-5p. The study suggests a circRNA/miRNA/mRNA (ceRNA-like) relationship where reduced circ-TubD1 may contribute to increased TRAF6, and circ-TubD1 has diagnostic potential by ROC analysis."	0.5465
38967046	Bioscience reports	2024	Functional analysis of a panel of molecular markers for diagnosis of systemic lupus erythematosus in rats.	rno_circ_0044235	circ-0044235	rno_circ_CDC27	CDC27	systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	up-regulated	RT-qPCR	"circ-CDC27 (circ-0044235) is up-regulated in serum of SLE-induced rats and shows strong diagnostic performance by ROC analysis. Bioinformatics predicts it may sponge rno-miR-883-5p, rno-miR-802-5p, and rno-miR-3561-5p within a circRNA_miRNA_mRNA network and be involved in immune-related pathways."	0.5465
38967046	Bioscience reports	2024	Functional analysis of a panel of molecular markers for diagnosis of systemic lupus erythematosus in rats.	rno_circ_0140271	circ-0140271	rno_circ_MED14	MED14	systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	up-regulated	RT-qPCR	circ-Med14 (circ-0140271) is up-regulated in serum of SLE-induced rats and shows diagnostic value by ROC analysis. Bioinformatics predicts it sponges rno-miR-582-3p and rno-miR-764-3p and may relate to MAPK-related signaling among enriched pathways.	0.5465
38974999	Molecular therapy. Nucleic acids	2024	"CircHTT(2,3,4,5,6) - co-evolving with the HTT CAG-repeat tract - modulates Huntington's disease phenotypes."	hsa_circ_0001392	"circHTT(2,3,4,5,6) / hsa_circHTT_004"	hsa_circ_HTT	HTT	Huntington¡¯s disease / HD	MONDO:0007739	Huntington disease	up-regulated	RT-qPCR; Northern Blot	"circHTT(2,3,4,5,6) (from the HTT locus, exons 2_6) is increased in Huntington¡¯s disease models and in HD patient iPSC-derived neurons, correlating with CAG repeat length. It is mainly cytoplasmic, shows predicted RBP-binding enrichment and partial association with the 40S ribosomal subunit, and its overexpression in HD-relevant striatal cells modulates focal-adhesion-related morphology/adhesion defects."	0.7006
38974999	Molecular therapy. Nucleic acids	2024	"CircHTT(2,3,4,5,6) - co-evolving with the HTT CAG-repeat tract - modulates Huntington's disease phenotypes."		"circHtt(2,3,4,5,6)"	mmu_circ_Htt	Htt	Huntington¡¯s disease / HD	MONDO:0007739	Huntington disease	up-regulated	RT-qPCR	"Mouse circHtt(2,3,4,5,6) is aberrantly upregulated in HD knockin models (e.g., zQ175) across multiple brain regions. It is mainly cytoplasmic, partly associates with the 40S ribosomal subunit, and when overexpressed in mutant STHdh Q111/Q111 striatal cells it mitigates focal-adhesion-linked morphology/adhesion defects."	0.6853
38977695	Nature communications	2024	CircCDC42-encoded CDC42-165aa regulates macrophage pyroptosis in Klebsiella pneumoniae infection through Pyrin inflammasome activation.	mmu_circ_0011319	circCDC42	mmu_circ_CDC42	CDC42	Klebsiella pneumoniae infection / KP infection	MONDO:0030602	Klebsiella pneumonia	up-regulated	RT-qPCR; RNA-seq	"circCDC42 (mmu_circ_0011319), derived from CDC42, is up-regulated in KP-infected murine alveolar macrophages and lung tissue. It encodes the peptide CDC42-165aa, which competitively binds DOCK8 to inhibit CDC42 activation, thereby hyperactivating the Pyrin inflammasome and promoting caspase-1/GSDMD-dependent pyroptosis and inflammatory cytokine release. In vivo knockdown of circCDC42 alleviates KP-induced lung injury and improves mouse survival."	0.8446
38978876	Frontiers in genetics	2024	N6-methyladenosine methylation analysis of circRNAs in acquired middle ear cholesteatoma.		hsa_circRNA_061554			middle ear cholesteatoma	MONDO:0006533	cholesteatoma of middle ear	unknown	Microarray	hsa_circRNA_061554 shows significantly increased m6A methylation in middle ear cholesteatoma versus normal post-auricular skin and was among five circRNAs used to build a ceRNA network for exploring potential mechanisms in cholesteatoma etiology.	0.5135
38978876	Frontiers in genetics	2024	N6-methyladenosine methylation analysis of circRNAs in acquired middle ear cholesteatoma.		hsa_circRNA_001454			middle ear cholesteatoma	MONDO:0006533	cholesteatoma of middle ear	unknown	Microarray	hsa_circRNA_001454 is hypermethylated at m6A level in middle ear cholesteatoma compared with normal post-auricular skin and was included among the five circRNAs used to construct a circRNA-miRNA-mRNA network to explore potential ceRNA mechanisms in cholesteatoma.	0.5135
38978876	Frontiers in genetics	2024	N6-methyladenosine methylation analysis of circRNAs in acquired middle ear cholesteatoma.		hsa_circRNA_031526			middle ear cholesteatoma	MONDO:0006533	cholesteatoma of middle ear	unknown	Microarray	hsa_circRNA_031526 is significantly hypermethylated at m6A level in middle ear cholesteatoma compared with normal skin and served as one of the five validated circRNAs used for downstream ceRNA network analysis in this study.	0.5135
38978876	Frontiers in genetics	2024	N6-methyladenosine methylation analysis of circRNAs in acquired middle ear cholesteatoma.		hsa_circRNA_100833 / circFADS2	hsa_circ_FADS2	FADS2	middle ear cholesteatoma	MONDO:0006533	cholesteatoma of middle ear	unknown	Microarray	hsa_circRNA_100833 (circFADS2) shows significantly decreased m6A methylation in middle ear cholesteatoma and was one of five validated circRNAs used to construct a ceRNA network; the paper does not establish a cholesteatoma-specific downstream miRNA/mRNA axis for it.	0.5135
38978876	Frontiers in genetics	2024	N6-methyladenosine methylation analysis of circRNAs in acquired middle ear cholesteatoma.		hsa_circRNA_022382			middle ear cholesteatoma	MONDO:0006533	cholesteatoma of middle ear	unknown	Microarray	hsa_circRNA_022382 shows significantly decreased m6A methylation in middle ear cholesteatoma versus normal skin and was included among the five validated circRNAs used for ceRNA-network-based exploration; no specific downstream miRNA/mRNA targets were experimentally validated for it in this paper.	0.5135
38981022	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2024	CircCFL1 Promotes TNBC Stemness and Immunoescape via Deacetylation-Mediated c-Myc Deubiquitylation to Facilitate Mutant TP53 Transcription.	hsa_circ_0000328	circCFL1	hsa_circ_CFL1	CFL1	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circCFL1 is up-regulated in TNBC and promotes proliferation, metastasis and stemness. It functions as a scaffold to enhance HDAC1_c-Myc interaction, leading to c-Myc deacetylation and reduced K48-linked ubiquitylation, stabilizing c-Myc and thereby increasing mutant TP53 transcription and activating the p-AKT/WIP/YAP/TAZ axis. circCFL1 also promotes PD-L1 expression and suppresses CD8+ T-cell antitumor immunity, contributing to immune escape and poorer prognosis."	0.8998
38981023	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2024	CircHIPK2 Contributes Cell Growth in Intestinal Epithelial of Colitis and Colorectal Cancer through Promoting TAZ Translation.	hsa_circ_0001756	circHIPK2 / hsa_circRNA_104507	hsa_circ_HIPK2	HIPK2	inflammatory bowel disease	MONDO:0005265	inflammatory bowel disease	up-regulated	RT-qPCR; Microarray	"circHIPK2 is up-regulated in IBD and CRC. It promotes intestinal epithelial/CRC cell growth by recruiting EIF4A3 (with FUS supporting circHIPK2 biogenesis) to enhance TAZ translation, thereby activating Hippo/YAP/TAZ downstream targets such as CCN1 and CCN2; circHipk2 knockdown worsens DSS colitis but reduces colitis-associated tumorigenesis."	0.8826
38981928	Journal of molecular neuroscience : MN	2024	Investigation of the Circular Transcriptome in Alzheimer's Disease Brain.		circTFDP2	hsa_circ_TFDP2	TFDP2	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RNA-seq	circTFDP2 is one of the top upregulated circRNAs identified in dorsolateral prefrontal cortex samples from AD patients versus controls based on RNA-seq differential expression analysis. No specific mechanism or functional axis was investigated for this circRNA in the study.	0.1768
38981928	Journal of molecular neuroscience : MN	2024	Investigation of the Circular Transcriptome in Alzheimer's Disease Brain.		circATP13A3	hsa_circ_ATP13A3	ATP13A3	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RNA-seq	circATP13A3 is uniquely expressed/upregulated in AD dorsolateral prefrontal cortex compared with controls based on RNA-seq analysis (control CPM average reported as 0). The study did not further characterize its downstream mechanism.	0.1768
38981928	Journal of molecular neuroscience : MN	2024	Investigation of the Circular Transcriptome in Alzheimer's Disease Brain.		circSEPTIN7	hsa_circ_SEPTIN7	SEPTIN7	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RNA-seq	circSEPTIN7 is a top upregulated circRNA in AD dorsolateral prefrontal cortex identified by RNA-seq differential expression. The paper did not experimentally validate or mechanistically characterize circSEPTIN7.	0.1768
38981928	Journal of molecular neuroscience : MN	2024	Investigation of the Circular Transcriptome in Alzheimer's Disease Brain.		circMCF2L2	hsa_circ_MCF2L2	MCF2L2	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RNA-seq	circMCF2L2 is among the top upregulated circRNAs detected in AD dorsolateral prefrontal cortex by RNA-seq. The study reports differential expression but does not provide functional validation or a regulatory axis for this circRNA.	0.1768
38981928	Journal of molecular neuroscience : MN	2024	Investigation of the Circular Transcriptome in Alzheimer's Disease Brain.		circCCZ1B	hsa_circ_CCZ1B	CCZ1B	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RNA-seq	"circCCZ1B is reported as one of the top upregulated circRNAs in AD dorsolateral prefrontal cortex in this RNA-seq-based analysis, without further mechanistic validation."	0.1768
38981928	Journal of molecular neuroscience : MN	2024	Investigation of the Circular Transcriptome in Alzheimer's Disease Brain.		circFANCB	hsa_circ_FANCB	FANCB	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RNA-seq	"circFANCB is uniquely expressed/upregulated in AD dorsolateral prefrontal cortex versus controls and was included among the top ten upregulated circRNAs. It was computationally predicted to contain miRNA-binding sites, but no specific miRNA/mRNA axis was established for circFANCB."	0.1768
38981928	Journal of molecular neuroscience : MN	2024	Investigation of the Circular Transcriptome in Alzheimer's Disease Brain.		circUBE4B	hsa_circ_UBE4B	UBE4B	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RNA-seq	"circUBE4B is upregulated in AD dorsolateral prefrontal cortex. Bioinformatic prediction suggests it may function as a miRNA sponge (not experimentally validated), with a proposed circUBE4B_hsa-miR-328-5p_CD44 ceRNA axis potentially contributing to AD pathology and biomarker potential."	0.1768
38981928	Journal of molecular neuroscience : MN	2024	Investigation of the Circular Transcriptome in Alzheimer's Disease Brain.		circFASTKD1	hsa_circ_FASTKD1	FASTKD1	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RNA-seq	"circFASTKD1 is uniquely expressed/upregulated in AD dorsolateral prefrontal cortex versus controls and was computationally predicted to have miRNA-binding sites, but no specific downstream target or axis was established."	0.1768
38981928	Journal of molecular neuroscience : MN	2024	Investigation of the Circular Transcriptome in Alzheimer's Disease Brain.		circPICALM	hsa_circ_PICALM	PICALM	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RNA-seq	"circPICALM is upregulated in AD dorsolateral prefrontal cortex based on RNA-seq analysis and was included among circRNAs examined for predicted miRNA-binding sites, but no specific miRNA/mRNA regulatory axis was presented for circPICALM."	0.1768
38981928	Journal of molecular neuroscience : MN	2024	Investigation of the Circular Transcriptome in Alzheimer's Disease Brain.		circGTF2I	hsa_circ_GTF2I	GTF2I	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RNA-seq	"circGTF2I is reported as one of the top upregulated circRNAs in AD dorsolateral prefrontal cortex based on RNA-seq differential expression, without downstream functional or mechanistic analyses."	0.1768
38983125	Oncology letters	2024	Mucin 1 expression is regulated by hsa_circ_0055054/microRNA_122_5p and promotes hepatocellular carcinoma development.	hsa_circ_0055054		hsa_circ_GFPT1	GFPT1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0055054 is up-regulated in HCC and promotes HCC cell proliferation, migration and invasion. It functions as a ceRNA by binding miR-122-5p, thereby increasing MUC1 expression; circRNA knockdown suppresses tumor growth in a MHCC97L xenograft model."	0.7416
38984054	JACC. Basic to translational science	2024	Shear-Sensitive circRNA-LONP2 Promotes Endothelial Inflammation and Atherosclerosis by Targeting NRF2/HO1 Signaling.	hsa_circ_0008558	circRNA-LONP2	hsa_circ_LONP2	LONP2	atherosclerosis / AS	MONDO:0005311	atherosclerosis	down-regulated	RT-qPCR; Microarray	"In endothelial cells, circRNA-LONP2 is shear-sensitive and is down-regulated by atheroprotective laminar shear stress. It promotes oxidative stress, endothelial inflammation, and atherosclerosis mainly by sponging miR-200a-3p to regulate KEAP1 and/or YAP1/EZH2, thereby inhibiting NRF2/HO-1 signaling."	0.8033
38984054	JACC. Basic to translational science	2024	Shear-Sensitive circRNA-LONP2 Promotes Endothelial Inflammation and Atherosclerosis by Targeting NRF2/HO1 Signaling.		circRNA-Lonp2 / mouse circRNA-Lonp2	mmu_circ_Lonp2	Lonp2	atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"Mouse circRNA-Lonp2 promotes oxidative stress and endothelial inflammation in mouse endothelial cells. Its effects are mediated through the conserved miR-200a-3p/Yap1/Ezh2 axis that suppresses Nrf2/Ho-1 signaling, rather than through Keap1 in mice."	0.3957
38984951	Journal of cellular and molecular medicine	2024	Upregulation of circ-IGF1R increased therapeutic effect of hypoxia-pretreated ADSC-derived extracellular vesicle by regulating miR-503-5p/HK2/VEGFA axis.	mmu_circ_0001582	circ_IGF1R	mmu_circ_IGF1R	IGF1R	diabetes mellitus / DM	MONDO:0005015	diabetes mellitus	up-regulated	RT-qPCR; RNA-seq	"circ-IGF1R (mmu_circ_0001582) is upregulated in hypoxia-pretreated ADSC-derived extracellular vesicles and is required for their pro-angiogenic, pro-wound-healing effects in diabetic mice. Mechanistically, it sponges miR-503-5p to increase HK2 and VEGFA (and promote HIF-1alpha), thereby reducing endothelial apoptosis and enhancing angiogenic differentiation under high-glucose conditions."	0.7507
38987793	Journal of experimental & clinical cancer research : CR	2024	"N6-methyladenosine modification of circMARK2 enhances cytoplasmic export and stabilizes LIN28B, contributing to the progression of Wilms tumor."	hsa_circ_0022614	circMARK2	hsa_circ_MARK2	MARK2	Wilms tumor	MONDO:0019004	kidney Wilms tumor	up-regulated	RT-qPCR; Northern Blot; RNA-seq	"circMARK2 (hsa_circ_0022614) is upregulated in Wilms tumor and promotes WT cell proliferation, migration/invasion, and metastasis in vitro and in vivo. Mechanistically, m6A modification enables HNRNPC-mediated nuclear export of circMARK2, and cytoplasmic circMARK2 binds IGF2BP2 to stabilize LIN28B mRNA, activating the LIN28B/LET-7 oncogenic program and associating with poor patient DFS."	0.9038
38988519	Heliyon	2024	hsa_circ_0101050 regulated by ZC3H13 enhances tumorigenesis in papillary thyroid cancer via m6A modification.	hsa_circ_0101050		hsa_circ_UGGT2	UGGT2	papillary thyroid cancer / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0101050 is up-regulated in papillary thyroid cancer and promotes proliferation, migration, invasion, and xenograft tumor growth. ZC3H13 suppresses hsa_circ_0101050 by increasing its m6A modification, and hsa_circ_0101050 overexpression reverses ZC3H13¡¯s tumor-suppressive effects; high hsa_circ_0101050 is associated with worse survival."	0.7416
38988568	Heliyon	2024	CircGNAO1 strengthens its host gene GNAO1 expression for suppression of hepatocarcinogenesis.	hsa_circ_0039422	circGNAO1	hsa_circ_GNAO1	GNAO1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"circGNAO1 (hsa_circ_0039422) is down-regulated in HCC tissues/cell lines and higher expression predicts better overall survival. Functionally, circGNAO1 suppresses HCC cell proliferation, induces G1 arrest, and promotes senescence by increasing its host gene GNAO1 transcription. Mechanistically, it binds/sequesters DNMT1 to reduce DNMT1 occupancy on the GNAO1 promoter and counteract DNMT1-driven promoter methylation."	0.8133
38992592	BMC cancer	2024	Circ_0000069 promotes the development of hepatocellular carcinoma by regulating CCL25.	hsa_circ_0000069	circ_0000069 / circRNA_0000069			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	circ_0000069 (hsa_circ_0000069) is upregulated in hepatocellular carcinoma tissues and cell lines and promotes HCC cell migration/invasion. Its pro-tumor effects in vitro and xenograft growth in vivo are linked to positive regulation of CCL25 (and associated changes in MAP2K1/MEK1 protein levels).	0.6815
38992675	Molecular cancer	2024	ESRP1-mediated biogenesis of circPTPN12 inhibits hepatocellular carcinoma progression by PDLIM2/ NF-kappaB pathway.	hsa_circ_0003764	circPTPN12 / circ-0003764	hsa_circ_PTPN12	PTPN12	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"circPTPN12 is down-regulated in HCC and acts as a tumor suppressor by inhibiting proliferation and promoting apoptosis. Mechanistically, it binds PDLIM2 (PDZ domain) and scaffolds OTUD6B_PDLIM2 to maintain PDLIM2 stability, enhancing PDLIM2-mediated ubiquitination/degradation of P65 and suppressing NF-kappaB signaling; ESRP1 promotes circPTPN12 biogenesis."	0.8817
38993556	International journal of biological sciences	2024	PTBP1-mediated biogenesis of circATIC promotes progression and cisplatin resistance of bladder cancer.	hsa_circ_0058058	circATIC	hsa_circ_ATIC	ATIC	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circATIC is up-regulated in bladder cancer and DDP-resistant cells and promotes proliferation, invasion/metastasis, and cisplatin resistance. It is generated via PTBP1-dependent splicing and increases RCC2 expression by sponging miR-1247-5p and by forming a circATIC/LIN28A/RCC2 complex to stabilize RCC2 mRNA, thereby promoting EMT and activating JNK signaling. High circATIC expression correlates with metastasis and worse overall survival."	0.8913
38993677	iScience	2024	CircSMAD3 represses SMAD3 phosphorylation and ameliorates cardiac remodeling by recruiting YBX1.	hsa_circ_0003973	circSMAD3	hsa_circ_SMAD3	SMAD3	heart failure / HF	MONDO:0005252	heart failure	down-regulated	RT-qPCR	"circSMAD3 is down-regulated in murine heart failure/cardiac remodeling models and counteracts cardiomyocyte hypertrophy and cardiac fibroblast activation. It binds and stabilizes YBX1 (via reduced ubiquitination), promotes YBX1 nuclear functions and YBX1_SMAD3 interaction, thereby inhibiting SMAD3 phosphorylation and dampening TGFbeta/SMAD3 signaling, improving cardiac remodeling in vivo."	0.8518
38994017	Theranostics	2024	The orchestration of cell-cycle reentry and ribosome biogenesis network is critical for cardiac repair.		circASXL1 / circ-ASXL1	mmu_circ_ASXL1	ASXL1	Myocardial infarction / MI	MONDO:0005068	myocardial infarction	down-regulated	RT-qPCR	"In MI mouse hearts, circASXL1 is down-regulated. circASXL1 promotes cardiomyocyte cell-cycle reentry via a miR-1/CDK6/Rb1 axis and promotes cytokinesis by binding Ncl mRNA (5'UTR) to enhance Ncl-dependent ribosome biogenesis, mediating the therapeutic effect of UMSC-derived exosomes in cardiac repair."	0.7394
38994030	Theranostics	2024	Microglial circ-UBE2K exacerbates depression by regulating parental gene UBE2K via targeting HNRNPU.	hsa_circ_0009154	circ-UBE2K / circUBE2K	hsa_circ_UBE2K	UBE2K	major depressive disorder / MDD	MONDO:0002009	major depressive disorder	up-regulated	RT-qPCR; ISH; RNA-seq	"circ-UBE2K is up-regulated in MDD patient peripheral blood and in depression-model mouse brains, and its overexpression aggravates depressive-like behaviors. Mechanistically, circ-UBE2K binds the RBP HNRNPU to enhance host gene UBE2K expression, promoting abnormal microglial activation and neuroinflammation and contributing to synaptic/neuronal damage."	0.7422
38994041	Heliyon	2024	Hsa_circRNA_101036 aggravates hypoxic-induced endoplasmic reticulum stress via the miR-21-3p/TMTC1 axis in oral squamous cell carcinoma.		hsa_circRNA_101036	hsa_circ_TMTC1	TMTC1	Oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR	"In OSCC, hsa_circRNA_101036 is down-regulated and functions as a tumor-suppressive circRNA. Mechanistically, it sponges miR-21-3p to increase/stabilize TMTC2, thereby aggravating hypoxia-associated ER stress and promoting apoptosis and ROS, which suppresses tumor growth in xenograft models."	0.6542
38994162	World journal of gastrointestinal oncology	2024	Circ_0004592: An auxiliary diagnostic biomarker for gastric cancer.	hsa_circ_0004592	Circ_0004592	hsa_circ_STK3	STK3	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"circ_0004592 (hsa_circ_0004592, from STK3) is up-regulated in gastric cancer tissues and patient plasma, including in precancerous lesions compared with healthy controls. Plasma levels decrease after tumor resection and show diagnostic value (ROC AUC ~0.787), with higher levels associated with invasion depth and lymph node metastasis."	0.6481
38994627	Combinatorial chemistry & high throughput screening	2025	CircDUSP22 Attenuates the Ferroptosis of Prostate Cancer Cells via miR-18a-5p/SLC7A11/GPX4 Signaling.		circDUSP22	hsa_circ_DUSP22	DUSP22	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	"circDUSP22 is up-regulated in prostate cancer plasma and cell lines and promotes malignant phenotypes (proliferation, migration, invasion). Mechanistically, it sponges miR-18a-5p to increase SLC7A11 (and GPX4), thereby inhibiting ferroptosis."	0.8537
38997803	Clinical and translational medicine	2024	A hidden proteome encoded by circRNAs in human placentas: Implications for uncovering preeclampsia pathogenesis.	hsa_circ_0000682	CircPRKCB / hsa_circ_15387	hsa_circ_PRKCB	PRKCB	preeclampsia	MONDO:0005081	preeclampsia	down-regulated	RT-qPCR; RNA-seq	"CircPRKCB (hsa_circ_0000682) is down-regulated in preeclamptic placentas. It encodes the microprotein circPRKCB119aa, which acts as a bait to inhibit PKCbeta phosphorylation, suppress Akt phosphorylation, and thereby promotes trophoblast autophagy and pro-invasive/vascular-remodelling phenotypes, suggesting relevance to preeclampsia pathogenesis."	0.8355
39006198	International journal of molecular and cellular medicine	2023	Has_circ_0008285/miR-211-5p/SIRT-1 Axis Suppress Ovarian Cancer Cells Progression.	hsa_circ_0008285				ovarian cancer	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0008285 is up-regulated in ovarian cancer tissues and cell lines and promotes malignant phenotypes. Mechanistically, it sponges miR-211-5p to relieve repression of SIRT-1, thereby enhancing proliferation and invasion and reducing apoptosis."	0.6815
39006913	International journal of general medicine	2024	Screening of a Prognostic Gene Signature for Relapsed/Refractory Acute Myeloid Leukemia Based on Altered Circulating CircRNA Profiles.	hsa_circ_0051239		hsa_circ_ATP5SL	ATP5SL	Relapsed/refractory acute myeloid leukemia / R/R-AML	MONDO:0004996	childhood acute myeloid leukemia	up-regulated	Microarray	"This circRNA is identified as upregulated in circulating PBMC samples from R/R-AML compared with de novo AML in a circRNA microarray analysis. Its potential circRNA/miRNA/mRNA regulatory relationships were explored by bioinformatics network analysis, but no specific functional mechanism was experimentally validated."	0.1768
39006913	International journal of general medicine	2024	Screening of a Prognostic Gene Signature for Relapsed/Refractory Acute Myeloid Leukemia Based on Altered Circulating CircRNA Profiles.	hsa_circ_0008135	hsa_circRNA_102491	hsa_circ_HOMER3	HOMER3	Relapsed/refractory acute myeloid leukemia / R/R-AML	MONDO:0004996	childhood acute myeloid leukemia	up-regulated	Microarray	"This circRNA is reported as upregulated in R/R-AML versus de novo AML in circulating PBMC samples based on circRNA microarray profiling. The study performed bioinformatics prediction of its circRNA/miRNA/mRNA network, without experimental functional validation."	0.1768
39006913	International journal of general medicine	2024	Screening of a Prognostic Gene Signature for Relapsed/Refractory Acute Myeloid Leukemia Based on Altered Circulating CircRNA Profiles.	hsa_circ_0005402	hsa_circRNA_101539	hsa_circ_ANXA2	ANXA2	Relapsed/refractory acute myeloid leukemia / R/R-AML	MONDO:0004996	childhood acute myeloid leukemia	up-regulated	Microarray	"This circRNA is among the upregulated candidate DE-circRNAs in R/R-AML versus de novo AML identified by circRNA microarray in PBMCs. The study only provides predicted circRNA/miRNA/mRNA network and pathway enrichment context, without direct mechanistic experiments for this circRNA."	0.1768
39006913	International journal of general medicine	2024	Screening of a Prognostic Gene Signature for Relapsed/Refractory Acute Myeloid Leukemia Based on Altered Circulating CircRNA Profiles.	hsa_circ_0031419	hsa_circRNA_101330	hsa_circ_SCFD1	SCFD1	Relapsed/refractory acute myeloid leukemia / R/R-AML	MONDO:0004996	childhood acute myeloid leukemia	down-regulated	Microarray	"This circRNA is identified as a downregulated candidate DE-circRNA in R/R-AML versus de novo AML using PBMC circRNA microarray data. Its potential involvement was explored through predicted circRNA/miRNA/mRNA networks and enrichment analyses, without direct experimental validation."	0.1768
39006913	International journal of general medicine	2024	Screening of a Prognostic Gene Signature for Relapsed/Refractory Acute Myeloid Leukemia Based on Altered Circulating CircRNA Profiles.		hsa_circRNA_406642			Relapsed/refractory acute myeloid leukemia / R/R-AML	MONDO:0004996	childhood acute myeloid leukemia	down-regulated	Microarray	"This circRNA (reported without a circBase ID) is a downregulated candidate in R/R-AML versus de novo AML based on PBMC circRNA microarray profiling. The paper includes only computational circRNA/miRNA/mRNA network analysis and enrichment context for candidate circRNAs, without specific experimental validation for this circRNA."	0.1768
39006913	International journal of general medicine	2024	Screening of a Prognostic Gene Signature for Relapsed/Refractory Acute Myeloid Leukemia Based on Altered Circulating CircRNA Profiles.	hsa_circ_0039522	hsa_circRNA_101819	hsa_circ_NLRC5	NLRC5	Relapsed/refractory acute myeloid leukemia / R/R-AML	MONDO:0004996	childhood acute myeloid leukemia	down-regulated	Microarray	"This circRNA is a downregulated candidate DE-circRNA in R/R-AML versus de novo AML identified by circRNA microarray in PBMCs. Bioinformatics analysis suggests it may function as a miRNA sponge with MREs for has-miR-15a-5p/has-miR-15b-5p and other miRNAs, indicating a potential ceRNA-related role in R/R-AML progression."	0.1768
39014449	Journal of cardiothoracic surgery	2024	circPTP4A2 knockdown suppresses NSCLC progression via regulating proliferation and activating anti-tumor immunity.	hsa_circ_0007364	circPTP4A2 / circ_0007364	hsa_circ_PTP4A2	PTP4A2	Non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circPTP4A2 is up-regulated in NSCLC serum, tumor tissues and cell lines, and shows diagnostic potential (ROC AUC ~0.90). Silencing circPTP4A2 suppresses NSCLC cell proliferation/migration/invasion and enhances antitumor immune responses in co-culture assays, suggesting it promotes immune escape in vitro."	0.7078
39022816	Journal of cellular and molecular medicine	2024	EIF4A3-Induced CircDHTKD1 regulates glycolysis in non-small cell lung cancer via stabilizing PFKL.	hsa_circ_0003074	circDHTKD1 / circ_0003074	hsa_circ_DHTKD1	DHTKD1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circDHTKD1 (hsa_circ_0003074), derived from DHTKD1, is up-regulated in NSCLC tissues and cell lines and promotes malignant phenotypes and tumor growth. Mechanistically, EIF4A3 increases circDHTKD1, which recruits the m6A reader IGF2BP2 to stabilize PFKL mRNA, thereby enhancing glycolysis."	0.8267
39026501	Acta biochimica et biophysica Sinica	2024	Identification and validation of disease severity-related circular RNA in acute pancreatitis.	hsa_circ_0007798	circ_0007798 / circMAP3K5	hsa_circ_MAP3K5	MAP3K5	acute pancreatitis / AP	MONDO:0006515	acute pancreatitis	down-regulated	RT-qPCR; Microarray	"circMAP3K5 (circ_0007798) is down-regulated in acute pancreatitis blood samples and in a cerulein-induced acinar cell model. Functional assays indicate circMAP3K5 suppresses inflammatory cytokine release (IL-1beta, IL-6, TNF-alpha), and bioinformatics suggests a potential ceRNA network involving miR-148a-3p/miR-148b-3p/miR-199a-5p/miR-199b-5p and downstream mRNAs. Clinically, its expression level correlates with and may help grade AP severity."	0.6956
39027611	Heliyon	2024	The endogenous association among MMP2/miR-1248/Circ_0087558/miR-643/ MAP2K6 axis can contribute to brain metastasis in basal-like subtype of breast cancer.	hsa_circ_0087558	circ_0087558			breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RNA-seq	"circ_0087558 is reported as up-regulated in basal-like breast cancer brain metastasis tissues (vs primary) and is predicted to function in a ceRNA network by sponging miRNAs (e.g., miR-1248, miR-604, miR-643) to influence metastasis-related mRNAs such as MMP2 and MAP2K6. The evidence is based on RNA-seq and bioinformatic network analyses without experimental validation."	0.1768
39027611	Heliyon	2024	The endogenous association among MMP2/miR-1248/Circ_0087558/miR-643/ MAP2K6 axis can contribute to brain metastasis in basal-like subtype of breast cancer.	hsa_circ_0004503	circ_0004503			breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RNA-seq	"circ_0004503 is reported as up-regulated in basal-like breast cancer brain metastasis (vs primary) and is included as a circRNA node in the constructed circRNA_miRNA_mRNA network, but no specific miRNA axis/mechanistic detail is provided for this circRNA in the text."	0.1768
39030638	Journal of experimental & clinical cancer research : CR	2024	Hypoxia-enhanced YAP1-EIF4A3 interaction drives circ_0007386 circularization by competing with CRIM1 pre-mRNA linear splicing and promotes non-small cell lung cancer progression.	hsa_circ_0007386	circ_0007386	hsa_circ_CRIM1	CRIM1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ_0007386 is up-regulated in NSCLC and predominantly localized in the cytoplasm. It promotes NSCLC cell proliferation and tumor growth and inhibits apoptosis by sponging miR-383-5p to increase CIRBP, thereby activating PI3K/AKT signaling. Under hypoxia, enhanced YAP1_EIF4A3 interaction favors CRIM1 back-splicing and increases circ_0007386 biogenesis; high circ_0007386 predicts poorer overall survival."	0.8933
39031804	The Kaohsiung journal of medical sciences	2024	circUQCRC2 promotes asthma progression in children by activating the VEGFA/NF-kappaB pathway by targeting miR-381-3p.	mmu_circ_0038467	circUQCRC2 / circ_0038467	mmu_circ_Uqcrc2	UQCRC2	childhood asthma	MONDO:0005405	childhood onset asthma	up-regulated	RT-qPCR	"In OVA-induced asthmatic mice and PDGF-BB-treated mouse SMCs, circUQCRC2 is up-regulated and promotes asthma-related inflammation, oxidative stress, airway remodeling, and SMC proliferation/migration. It functions mainly in the cytoplasm as a miR-381-3p sponge to upregulate VEGFA and activate the NF-kappaB cascade; circUQCRC2 knockdown alleviates these asthma phenotypes."	0.7014
39034401	Cancer cell international	2024	Circular RNA circ_ARHGEF28 inhibits MST1/2 dimerization to suppress Hippo pathway to induce cisplatin resistance in ovarian cancer.		circ_ARHGEF28	hsa_circ_ARHGEF28	ARHGEF28	ovarian cancer	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circ_ARHGEF28 is up-regulated in cisplatin-resistant ovarian cancer tissues/cells and promotes cisplatin resistance. Mechanistically, it binds MST1/2 (SARAH domains) to inhibit MST1/2 dimerization, suppressing Hippo signaling and favoring YAP/TAZ accumulation and nuclear translocation; clinically, high circ_ARHGEF28 is associated with worse PFS."	0.8778
39036604	Non-coding RNA research	2024	Circular RNA LMBR1 inhibits bladder cancer progression by enhancing expression of the protein ALDH1A3.	hsa_circ_0003511	circLMBR1	hsa_circ_LMBR1	LMBR1	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"circLMBR1 (hsa_circ_0003511) is down-regulated in bladder cancer tissues and cell lines and functions as a tumor suppressor by inhibiting proliferation, invasion, migration, and metastasis. Mechanistically, it binds ALDH1A3 and increases ALDH1A3 protein expression, and ALDH1A3 knockdown reverses circLMBR1¡¯s inhibitory effects in vitro and in vivo."	0.8447
39038813	Cancer science	2024	CircMAN1A2_009 facilitates YBX1 nuclear localization to induce GLO1 activation for cervical adenocarcinoma cell growth.	hsa_circ_0000119	circMAN1A2_009	hsa_circ_MAN1A2	MAN1A2	cervical adenocarcinoma / CADC	MONDO:0005153	cervical adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circMAN1A2_009 is up-regulated in cervical adenocarcinoma and promotes CADC cell growth and tumorigenesis while suppressing ROS accumulation and apoptosis. Mechanistically, it binds YBX1 to enhance p-YBX1S102 and YBX1 nuclear localization, thereby activating GLO1 expression; it also shows diagnostic potential (AUC 0.8075)."	0.8933
39039600	Journal of ovarian research	2024	Hsa_circ_0043532 contributes to PCOS through upregulation of CYP19A1 by acting as a ceRNA for hsa-miR-1270.	hsa_circ_0043532	circ_0043532			Polycystic ovarian syndrome / PCOS	MONDO:0008487	polycystic ovary syndrome	up-regulated	RT-qPCR	"In granulosa cells from PCOS patients, circ_0043532 is up-regulated and promotes estradiol production/aberrant steroidogenesis. It functions as a ceRNA by sponging miR-1270 to upregulate CYP19A1, and is proposed as a potential therapeutic target in PCOS."	0.704
39041323	eLife	2024	circHIPK3 nucleates IGF2BP2 and functions as a competing endogenous RNA.		circHIPK3	hsa_circ_HIPK3	HIPK3	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; RNA-seq	"In bladder cancer cells, circHIPK3 binds the RBP IGF2BP2 via an internal 11-mer motif and modulates IGF2BP2 availability to target mRNAs (e.g., STAT3), affecting target mRNA stability and proliferation/cell-cycle related programs. circHIPK3 can nucleate multiple IGF2BP2 molecules to form cytoplasmic condensates. Clinically, higher circHIPK3 expression is associated with better overall survival in NMIBC cohorts and differs between NMIBC and MIBC."	0.8633
39042659	PloS one	2024	CircRNA_012164/MicroRNA-9-5p axis mediates cardiac fibrosis in diabetic cardiomyopathy.		circRNA_012164 / mmu_circRNA_012164 / circ012164	mmu_circ_Hist1h1c	Hist1h1c	diabetic cardiomyopathy	MONDO:0004994	cardiomyopathy	up-regulated	RT-qPCR	"In diabetic cardiomyopathy models (STZ-diabetic mouse hearts and high-glucose cardiac endothelial cells), circRNA_012164 is up-regulated and contributes to cardiac fibrotic responses. Its knockdown restores miR9 levels and attenuates high-glucose_induced fibrotic/mesenchymal markers, supporting a circRNA_012164_miR9 axis regulating downstream fibrosis-related genes."	0.5925
39043840	Scientific reports	2024	circRNA-0015004 act as a ceRNA to promote RCC2 expression in hepatocellular carcinoma.	hsa_circ_0015004	hsa-circRNA-0015004 / circ-0015004	hsa_circ_SDHC	SDHC	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circ-0015004 (from SDHC) is up-regulated in HCC tissues and cell lines, mainly localized in the cytoplasm, and promotes HCC proliferation and xenograft tumor growth. It acts as a ceRNA that sponges miR-330-3p to increase RCC2 expression, and its transcription is positively regulated by YY1. High circ-0015004 expression is associated with worse clinicopathological features and poorer overall survival."	0.8389
39044746	Cancer management and research	2024	"Silencing Exosomal circ102927 Inhibits Foot Melanoma Metastasis via Regulating Invasiveness, Epithelial-Mesenchymal Transition and Apoptosis."		circRNA102927 / circ102927			melanoma	MONDO:0005105	melanoma	up-regulated	RT-qPCR; Microarray	"Exosomal circRNA102927 is up-regulated in foot metastatic melanoma and promotes metastatic phenotypes. Its knockdown suppresses proliferation, migration, invasion and EMT while increasing apoptosis in A2058 metastatic melanoma cells; overexpression shows the opposite effects. It is suggested as a diagnostic biomarker by ROC analysis, and a predicted miR-3175 sponge, though the miRNA interaction lacks experimental validation."	0.7369
39048814	Cellular and molecular life sciences : CMLS	2024	CircARAP2 controls sMICA-induced NK cell desensitization by erasing CTCF/PRC2-induced suppression in early endosome marker RAB5A.	hsa_circ_0069396	circARAP2	hsa_circ_ARAP2	ARAP2	tumor immune evasion / NK cell desensitization	MONDO:0005046	immune system disorder	up-regulated	RT-qPCR; RNA-seq	"circARAP2 (hsa_circ_0069396), derived from ARAP2, is induced during sMICA-driven NK cell desensitization. It localizes mainly in the nucleus and binds CTCF to reduce CTCF/PRC2 occupancy at the RAB5A promoter, lowering repressive H3K27me3/H3K9me3 marks and increasing RAB5A transcription, thereby promoting NKG2D endocytosis and NK functional impairment."	0.816
39050152	Archives of medical science : AMS	2024	Circular RNA circ_001621 acts as a tumor promoter in lung cancer by regulating the miR-199a-3p/GREM1 axis.		circ_001621			lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circ_001621 is up-regulated in lung cancer tissues and cell lines and mainly localizes to the cytoplasm. Functionally, it promotes lung cancer cell viability and invasion while inhibiting apoptosis and enhancing tumor growth in a xenograft model, by sponging miR-199a-3p to upregulate GREM1."	0.762
39051062	Turkish journal of biology = Turk biyoloji dergisi	2024	Circ-METTL15 stimulates the aggressive behaviors of papillary thyroid cancer cells by coordinating the miR-200c-3p/XIAP axis.		circ-METTL15 / circ-methyltransferase-like 15	hsa_circ_METTL15	METTL15	papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circ-METTL15 is up-regulated in papillary thyroid carcinoma and promotes malignant phenotypes (proliferation, migration, invasion) while inhibiting apoptosis. Mechanistically, it sponges miR-200c-3p to derepress XIAP, forming a circ-METTL15/miR-200c-3p/XIAP regulatory axis."	0.6521
39053344	Translational oncology	2024	Hsa_Circ_0008035 drives immune evasion of gastric cancer via promoting EXT1-mediated nuclear translocation of PKM2.	hsa_circ_0008035		hsa_circ_EXT1	EXT1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0008035 is up-regulated in gastric cancer patient serum and cell lines and is associated with advanced stage and lymph node metastasis. It promotes tumor growth and immune evasion by encoding EXT1_219aa to suppress EXT1, thereby enhancing PKM2 nuclear translocation/activity and glycolysis through an EXT1/PKM2 axis, reducing CD8+ T-cell infiltration/function and anti-PD-L1 sensitivity."	0.6745
39056681	Biology	2024	Identification of a Novel hsa_circ_0058058/miR-324-5p Axis and Prognostic/Predictive Molecules for Acute Myeloid Leukemia Outcome by Bioinformatics-Based Analysis.	hsa_circ_0058058	circATIC	hsa_circ_ATIC	ATIC	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; RNA-seq; Microarray	"This study proposes, via bioinformatics analyses, that hsa_circ_0058058 (circATIC) participates in LAML through a circRNA_miRNA_mRNA axis by targeting miR-324-5p and thereby regulating AP1G1 and SP1. The inferred downstream effects include promotion of angiogenesis and support of cell-cycle/DNA replication-related programs, with potential biomarker/therapeutic relevance pending experimental and clinical validation."	0.2799
39071490	Open life sciences	2024	Circular RNAs as potential biomarkers for male severe sepsis.	hsa_circ_0008285	Circ-0008285	hsa_circ_CDYL	CDYL	sepsis	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR; Microarray	"hsa-circ-0008285 (from CDYL exons) is significantly up-regulated in plasma of male severe sepsis patients and was validated by qPCR. The study proposes it as a potential biomarker, and bioinformatics predicts a broad interaction network with miRNAs and mRNAs."	0.585
39071490	Open life sciences	2024	Circular RNAs as potential biomarkers for male severe sepsis.	hsa_circ_0001811		hsa_circ_STAU2	STAU2	sepsis	MONDO:0005229	bacterial infectious disease with sepsis	unknown	RT-qPCR; Microarray	"hsa-circ-0001811 (from STAU2 exons) is reported as a validated potential biomarker for severe sepsis, but the article does not explicitly state the direction of dysregulation or molecular mechanism for this circRNA in sepsis."	0.5541
39074152	PLoS genetics	2024	mRNA and circRNA mislocalization to synapses are key features of Alzheimer's disease.		circGSK3beta	hsa_circ_GSK3beta	GSK3beta	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	ISH; RNA-seq	"This circGSK3beta exon 9-to-7 isoform is up-regulated at AD synapses and, when overexpressed in neuron-differentiated SH-Sy5y cells, reduces phospho-tau and total GSK3beta levels, indicating a regulatory effect on tau phosphorylation in an AD-relevant context."	0.7165
39074152	PLoS genetics	2024	mRNA and circRNA mislocalization to synapses are key features of Alzheimer's disease.		circGSK3beta	hsa_circ_GSK3beta	GSK3beta	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	ISH; RNA-seq	"This circGSK3beta exon 10-to-9 isoform is down-regulated at AD synapses and, when overexpressed in neuron-differentiated SH-Sy5y cells, decreases phospho-tau (more strongly than the exon 9-to-7 isoform) and reduces total GSK3beta and phospho-S9 GSK3beta, supporting a role in modulating tau phosphorylation-related AD pathology."	0.7165
39077914	Stem cells translational medicine	2024	Three-dimensional cultured human umbilical cord mesenchymal stem cells attenuate pulmonary fibrosis by improving the balance of mitochondrial fusion and fission.		circRNA_102348 / circELP2	hsa_circ_ELP2	ELP2	pulmonary fibrosis	MONDO:0002771	pulmonary fibrosis	up-regulated	RT-qPCR	"circELP2 is upregulated in fibrotic conditions and promotes fibroblast proliferation/migration and fibrotic protein expression. hucMSCs suppress pulmonary fibrosis partly by reducing circELP2 expression and weakening circELP2_miR-630 binding, thereby limiting YAP/TAZ nuclear translocation and downstream mLST8-associated mitochondrial fusion/fission imbalance."	0.5309
39080192	Discover oncology	2024	CircSorbs1 regulates myocardial regeneration and reduces cancer therapy-related cardiovascular toxicity through the Mir-99/GATA4 pathway.		CircSorbs1	mmu_circ_Sorbs1	Sorbs1	myocardial infarction / MI	MONDO:0005068	myocardial infarction	dysregulated	RT-qPCR	"CircSorbs1 is dysregulated in mouse heart injury models (up in MI, down after doxorubicin treatment) and promotes cardiomyocyte proliferation while inhibiting apoptosis. Mechanistically, it acts as a ceRNA that sponges miR-99, relieving miR-99-mediated repression of GATA4 and increasing downstream cyclin A2/E1 to drive cell-cycle progression and myocardial regeneration."	0.6737
39080693	Journal of translational medicine	2024	CircRHBDD1 promotes immune escape via IGF2BP2/PD-L1 signaling and acts as a nanotherapeutic target in gastric cancer.		circRHBDD1	hsa_circ_RHBDD1	RHBDD1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circRHBDD1 is up-regulated in gastric cancer and predicts poor prognosis. It promotes immune escape by increasing PD-L1 expression and suppressing CD8+ T cell infiltration/activity. Mechanistically, circRHBDD1 binds IGF2BP2 and interferes with TRIM25-mediated ubiquitination, stabilizing IGF2BP2, which enhances PD-L1 mRNA stability via m6A modification; nanoparticle-delivered si-circRHBDD1 sensitizes tumors to anti-PD-1 therapy in vivo."	0.8877
39081873	Journal of inflammation research	2024	Hsa_circ_0001359 in Serum Exosomes: A Promising Marker to Predict Bronchopulmonary Dysplasia in Premature Infants.	hsa_circ_0001359	hsa_circPHC3_023	hsa_circ_PHC3	PHC3	bronchopulmonary dysplasia / BPD	MONDO:0019091	bronchopulmonary dysplasia	dysregulated	RT-qPCR; RNA-seq	"This study identified serum exosomal hsa_circ_0001359 as continuously differentially expressed between BPD and non-BPD preterm infants and validated it by RT-qPCR. Its day-7 expression showed strong predictive performance for BPD (AUC 0.853; adjusted OR 6.033). A potential mechanism was bioinformatically predicted: hsa_circ_0001359 may sponge let-7 and relate to TGF-beta signaling, but this was not experimentally confirmed."	0.5202
39081873	Journal of inflammation research	2024	Hsa_circ_0001359 in Serum Exosomes: A Promising Marker to Predict Bronchopulmonary Dysplasia in Premature Infants.	hsa_circ_0001522	hsa_circCSNK1G3_004	hsa_circ_CSNK1G3	CSNK1G3	bronchopulmonary dysplasia / BPD	MONDO:0019091	bronchopulmonary dysplasia	dysregulated	RT-qPCR; RNA-seq	"This study identified serum exosomal hsa_circ_0001522 as continuously differentially expressed between BPD and non-BPD preterm infants and validated its differential expression by RT-qPCR. It showed modest predictive ability for BPD on day 7 (AUC 0.657), and no specific downstream mechanism was experimentally investigated."	0.5202
39082028	Heliyon	2024	A novel hsa_circ_0006903 circular RNA promotes tumor development and dendritic cells activated expression in infantile hemangioma.	hsa_circ_0006903				infantile hemangioma / IH	MONDO:0002407	capillary hemangioma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0006903 is up-regulated in infantile hemangioma and promotes HemEC proliferation, migration, and invasion in vitro. The study constructed a predicted ceRNA network and highlighted hsa_circ_0006903/miR-6721-5p/CACNA2D2 and hsa_circ_0006903/miR-4786-3p/ATP13A4 as candidate regulatory axes, with enrichment implicating p53 signaling."	0.5008
39085875	Molecular cancer	2024	Circular RNA hsa_circ_0000467 promotes colorectal cancer progression by promoting eIF4A3-mediated c-Myc translation.	hsa_circ_0000467	hsa_circRNA_0000467 / circ467	hsa_circ_SKA3	SKA3	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; Microarray	"hsa_circ_0000467 (circ467) is up-regulated in colorectal cancer and is associated with poor prognosis. It promotes CRC cell proliferation, growth and metastasis by binding eIF4A3, retaining it in the cytoplasm, and scaffolding eIF4A3 with c-Myc mRNA to enhance c-Myc translation and downstream c-Myc signaling (e.g., cyclin D2/CDK4, ZEB1, E-cadherin)."	0.8531
39090090	Cell death & disease	2024	M6A-methylated circPOLR2B forms an R-loop and regulates the biological behavior of glioma stem cells through positive feedback loops.	hsa_circ_0126701	circPOLR2B	hsa_circ_POLR2B	POLR2B	glioblastoma / GBM	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR; Microarray	"In glioblastoma stem cells, nuclear circPOLR2B is reduced and functions as a tumor-suppressive circRNA by inhibiting self-renewal, migration/invasion and promoting apoptosis. YTHDC1 recognizes m6A-modified circPOLR2B and promotes its nuclear export, reducing nuclear circPOLR2B-mediated R-loop formation with POLR2B and relieving repression of POLR2B, which ultimately elevates PBX1 (via APA) and stemness programs."	0.822
39094493	Poultry science	2024	"circRUNX2.2, highly expressed in Marek's disease tumor tissues, functions in cis to regulate parental gene RUNX2 expression."	gga_circ_0009437	circRUNX2.2	gga_circ_RUNX2	RUNX2	Marek's disease / MD	MONDO:0016101	neurolymphomatosis	up-regulated	RT-qPCR; RNA-seq	circRUNX2.2 (gga_circ_0009437) is up-regulated in MDV-induced chicken tumorous spleens and is mainly nuclear. It promotes MD lymphoma cell proliferation and enhances its host gene RUNX2 transcription in cis by binding the RUNX2 promoter region and recruiting proteins such as CHD9.	0.8375
39102213	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2024	CircNAP1L4 regulates pulmonary artery smooth muscle cell proliferation via the NAP1L4-mediated super-enhancer-driven glycolysis gene hexokinase II (HK II) in pulmonary hypertension.	hsa_circ_0020816	circNAP1L4	hsa_circ_NAP1L4	NAP1L4	pulmonary hypertension / PH	MONDO:0005149	pulmonary hypertension	down-regulated	RT-qPCR	"In pulmonary hypertension, circNAP1L4 is decreased in hypoxic HPASMCs and in patient plasma. Increasing circNAP1L4 suppresses glycolysis and PASMC proliferation by binding NAP1L4 and preventing its nuclear translocation, thereby reducing super-enhancer-driven HK II transcription; in vivo circNAP1L4 delivery alleviates SuHx-induced PH."	0.8029
39103836	Cancer cell international	2024	CircUBA2 promotes the cancer stem cell-like properties of gastric cancer through upregulating STC1 via sponging miR-144-5p.	hsa_circ_0006211	circUBA2	hsa_circ_UBA2	UBA2	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"In gastric cancer, circUBA2 is up-regulated and promotes proliferation, migration, metastasis and CSC-like properties. It functions as a ceRNA by sponging miR-144-5p to upregulate STC1, thereby activating IL-6/JAK2/STAT3 signaling; high circUBA2 indicates poor prognosis and may be a prognostic biomarker/therapeutic target."	0.8933
39107843	Molecular cancer	2024	Circular RNA ACVR2A promotes the progression of hepatocellular carcinoma through mir-511-5p targeting PI3K-Akt signaling pathway.	hsa_circ_0001073	circACVR2A / Circular RNA ACVR2A	hsa_circ_ACVR2A	ACVR2A	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circACVR2A is up-regulated in HCC cell lines and promotes HCC malignant phenotypes (proliferation, migration, invasion) while inhibiting apoptosis. Mechanistically, it sponges miR-511-5p, derepressing miR-511-5p targets and activating PI3K/AKT/FOXO1 signaling, thereby promoting tumor growth in xenograft models."	0.6444
39107881	Clinical and translational medicine	2024	A novel peptide encoded by circ-SLC9A6 promotes lipid dyshomeostasis through the regulation of H4K16ac-mediated CD36 transcription in NAFLD.	hsa_circ_0139807	circ_SLC9A6	hsa_circ_SLC9A6	SLC9A6	nonalcoholic fatty liver disease / NAFLD	MONDO:0013209	metabolic dysfunction-associated steatotic liver disease	up-regulated	RT-qPCR; RNA-seq; Microarray	"circ-SLC9A6 is up-regulated in NAFLD liver and promotes lipid dyshomeostasis mainly by encoding the peptide SLC9A6-126aa rather than acting as a miRNA sponge. Its abundance/translation is controlled by m6A-dependent YTHDF2-mediated degradation of circ-SLC9A6, and higher circ-SLC9A6 levels correlate with NAFLD progression in patients."	0.6138
39107881	Clinical and translational medicine	2024	A novel peptide encoded by circ-SLC9A6 promotes lipid dyshomeostasis through the regulation of H4K16ac-mediated CD36 transcription in NAFLD.	mmu_circ_0016305	circ_SLC9A6	mmu_circ_SLC9A6	SLC9A6	nonalcoholic fatty liver disease / NAFLD	MONDO:0013209	metabolic dysfunction-associated steatotic liver disease	up-regulated	RT-qPCR; RNA-seq; Microarray	"circ-SLC9A6 is up-regulated in NAFLD liver and promotes lipid dyshomeostasis mainly by encoding the peptide SLC9A6-126aa rather than acting as a miRNA sponge. Its abundance/translation is controlled by m6A-dependent YTHDF2-mediated degradation of circ-SLC9A6, and higher circ-SLC9A6 levels correlate with NAFLD progression in patients."	0.6138
39107958	Clinical and translational medicine	2024	Exosomal circ-0100519 promotes breast cancer progression via inducing M2 macrophage polarisation by USP7/NRF2 axis.	hsa_circ_0100519	circ_0100519	hsa_circ_EPSTI1	EPSTI1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circ-0100519 is up-regulated in breast cancer tissues and enriched in serum exosomes, where higher levels associate with poor prognosis. Tumor-secreted exosomal circ-0100519 is taken up by macrophages and promotes M2 polarization by scaffolding USP7 and NRF2 to enhance NRF2 deubiquitination/stability, thereby promoting breast cancer invasion and metastasis; HIF-1alpha upregulates circ-0100519 transcription."	0.8886
39113208	Thoracic cancer	2024	Novel circular RNA hsa_circ_0036683 suppresses proliferation and migration by mediating the miR-4664-3p/CDK2AP2 axis in non-small cell lung cancer.	hsa_circ_0036683	circ_36683 / circ-36683	hsa_circ_ABHD2	ABHD2	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; ISH	"hsa_circ_0036683 (circ-36683), a circRNA derived from ABHD2, is down-regulated in NSCLC tissues and lung cancer cell lines. It mainly localizes to the cytoplasm and suppresses NSCLC cell proliferation, migration, and xenograft growth by sponging miR-4664-3p to relieve repression of CDK2AP2, thereby promoting p53/p21/p27 and inhibiting CDK2/cyclin E1 to induce G0/G1 arrest."	0.8521
39113352	The clinical respiratory journal	2024	Circ_0028826 Promotes Growth and Metastasis of NSCLC via Acting as a Sponge of miR-758-3p to Derepress IDH2 Expression.	hsa_circ_0028826	circ_0028826	hsa_circ_GCN1L1	GCN1L1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"Circ_0028826 is upregulated in NSCLC tissues and cell lines, mainly localized in the cytoplasm, and promotes proliferation, migration/invasion and tumor growth while inhibiting apoptosis. Mechanistically, it sponges miR-758-3p to derepress IDH2, forming a circ_0028826/miR-758-3p/IDH2 regulatory axis."	0.7594
39114035	Heliyon	2024	The circZEB1/miR-337-3p/OGT axis mediates angiogenesis and metastasis via O-GlcNAcylation and up-regulating YBX1 in breast cancer.	hsa_circ_0000228	circZEB1	hsa_circ_ZEB1	ZEB1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circZEB1 (hsa_circ_0000228), derived from ZEB1, is up-regulated in breast cancer/TNBC and mainly localized in the cytoplasm. It promotes proliferation, migration/invasion, angiogenesis and metastasis by sponging miR-337_3p to upregulate OGT, enhancing O-GlcNAcylation and stabilizing YBX1, which then activates transcription of oncogenic targets such as FZD1, FGF10, NRP1 and HES5."	0.8415
39119899	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2024	LNMAC Promotes Cervical Squamous Cell Carcinoma Lymphatic Metastasis via Epigenetic Regulation of FGF2-Induced Lymphangiogenesis.	hsa_circ_0007905	LNMAC	hsa_circ_STX6	STX6	cervical squamous cell carcinoma / CSCC	MONDO:0006143	cervical squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"LNMAC is upregulated in CSCC, especially in lymph node metastatic cases, and its high expression indicates worse overall survival. Functionally, LNMAC promotes lymphangiogenesis and lymph node metastasis by binding HDAC1 and blocking Importin alpha6/8-mediated HDAC1 nuclear translocation, leading to increased H3K27ac and transcriptional activation of FGF2."	0.8998
39120858	Journal of bioenergetics and biomembranes	2024	CircRNA Arf3 suppresses glomerular mesangial cell proliferation and fibrosis in diabetic nephropathy via miR-107-3p/Tmbim6 axis.	mmu_circ_0000650	circ_Arf3 / CircRNA Arf3	mmu_circ_Arf3	Arf3	diabetic nephropathy / DN	MONDO:0005016	diabetic kidney disease	down-regulated	RT-qPCR	"circ_Arf3 is down-regulated under high-glucose conditions and in DN-related samples. Its overexpression inhibits mesangial cell proliferation and fibrosis by sponging miR-107-3p to derepress the miRNA target Tmbim6, forming a circ_Arf3/miR-107-3p/Tmbim6 ceRNA axis."	0.8111
39120980	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2024	CircUGP2 Suppresses Intrahepatic Cholangiocarcinoma Progression via p53 Signaling Through Interacting With PURB to Regulate ADGRB1 Transcription and Sponging miR-3191-5p.	hsa_circ_0001020	circUGP2	hsa_circ_UGP2	UGP2	intrahepatic cholangiocarcinoma / ICC	MONDO:0003210	intrahepatic cholangiocarcinoma	down-regulated	RT-qPCR; RNA-seq	"circUGP2 is down-regulated in intrahepatic cholangiocarcinoma and acts as a tumor suppressor. It binds PURB to co-activate ADGRB1 transcription and sponges miR-3191-5p to further increase ADGRB1, which blocks MDM2-mediated p53 polyubiquitination and activates p53 signaling, thereby inhibiting ICC growth and metastasis."	0.9034
39128090	The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology	2024	Circular RNA SNX27 Facilitates Gastric Cancer Progression By Sponging miR-638.	hsa_circ_0000130	circSNX27 / circ_100338 / circSXN27	hsa_circ_SNX27	SNX27	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circSNX27 is up-regulated in gastric cancer tissues and cell lines. Functionally, circSNX27 promotes GC cell viability/proliferation and migration/invasion while suppressing apoptosis, at least partly by sponging miR-638 and downregulating its expression."	0.7177
39132166	Journal of Cancer	2024	N6-methyladenosine-modified circ_0006168 promotes epithelial mesenchymal transition via miR-384/STAT3/Snail axis in esophageal squamous cell carcinoma.	hsa_circ_0006168	circ_0006168 / CircRNA_0006168	hsa_circ_CNOT6L	CNOT6L	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"circ_0006168 is up-regulated in ESCC and acts as an oncogenic circRNA. Its m6A modification (mainly via METTL3) is recognized by IGF2BP2 to enhance circ_0006168 stability/expression, and circ_0006168 promotes proliferation and EMT-related migration/invasion by sponging miR-384 to increase STAT3 and downstream Snail."	0.8416
39135128	The clinical respiratory journal	2024	Circular RNA NFIX Functions as an Oncogene in Non-Small Cell Lung Cancer by Modulating the miR-214-3p/TRIAP1 Axis.		circRNA NFIX	hsa_circ_NFIX	NFIX	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circRNA NFIX is up-regulated in NSCLC tissues and cell lines and functions as an oncogenic circRNA. It sponges miRNA-214-3p to relieve repression of TRIAP1, thereby promoting proliferation and inhibiting apoptosis in NSCLC cells."	0.6479
39138637	CNS neuroscience & therapeutics	2024	Role of the circRNA_34414/miR-6960a-5p/SIRT3 axis in postoperative delirium via CA1 Vglut1+ neurons in older mice.		circRNA_34414	mmu_circ_SIRT3	SIRT3	postoperative delirium / POD	MONDO:0002602	central nervous system disorder	down-regulated	RT-qPCR; Microarray	"circRNA_34414 is down-regulated in the hippocampus after anesthesia/surgery in aged mice and alleviates postoperative delirium-like behaviors when overexpressed. It mainly acts in the cytoplasm as a ceRNA sponge for miR-6960-5p, thereby upregulating SIRT3, reducing SOD2 acetylation, and improving mitochondrial membrane potential/mitochondrial function."	0.6397
39138880	Thoracic cancer	2024	Circ-PITX1 promotes non-small-cell lung cancer progression through regulating ETS1 expression via miR-615-5p.	hsa_circ_0074027	circ_PITX1	hsa_circ_PITX1	PITX1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ-PITX1 is up-regulated in NSCLC and promotes malignant phenotypes (proliferation, migration/invasion), glutamine catabolism, and tumor growth while inhibiting apoptosis. Mechanistically, it sponges miR-615-5p to increase ETS1 expression, forming a circ-PITX1/miR-615-5p/ETS1 axis."	0.8299
39139574	Frontiers in immunology	2024	Circ_BBS9 as an early diagnostic biomarker for lung adenocarcinoma: direct interaction with IFIT3 in the modulation of tumor immune microenvironment.	hsa_circ_0003162	circ_BBS9 / circBBS9	hsa_circ_BBS9	BBS9	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; Microarray	"circ_BBS9 (has_circ_0003162), derived from the BBS9 gene, is down-regulated in LUAD tissues and cell lines and acts as a tumor suppressor. Its overexpression inhibits LUAD cell proliferation and promotes ferroptosis, and it mechanistically binds IFIT3 and participates in a circ_BBS9/hsa-miR-7150/IFIT3 regulatory axis. Clinically, higher circ_BBS9 expression is associated with better survival and shows diagnostic potential by ROC analysis."	0.8703
39143552	Cellular & molecular biology letters	2024	METTL3-mediated m6A modification of circGLIS3 promotes prostate cancer progression and represents a potential target for ARSI therapy.	hsa_circ_0002874	circGLIS3	hsa_circ_GLIS3	GLIS3	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; ISH	"circGLIS3 (hsa_circ_0002874), derived from GLIS3, is up-regulated in prostate cancer and is associated with biochemical recurrence and worse BCR-free survival. METTL3-mediated m6A modification stabilizes circGLIS3, which sponges miR-661 to upregulate MDM2, suppress p53 signaling, and promote proliferation, migration, invasion, and tumor growth. circGLIS3 knockdown increases sensitivity to ARSI therapy (enzalutamide), partly linked to reduced MDM2/AR and increased p53."	0.8861
39155279	Cell death & disease	2024	Noncanonical formation of SNX5 gene-derived circular RNA regulates cancer growth.		circSNX5	hsa_circ_SNX5	SNX5	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circSNX5 is up-regulated in OSCC tumors and its high expression is associated with poorer patient survival. It promotes OSCC growth and metastasis and reduces drug sensitivity, mainly by sponging miR-323a-5p to maintain ADAM10 expression; its biogenesis is negatively regulated by the RBP STAU1 via a sequential back-splicing mechanism."	0.8747
39157602	EJHaem	2024	ciRS-7 circular RNA overexpression in plasma cells is a promising molecular biomarker of unfavorable prognosis in multiple myeloma.		ciRS-7 / CDR1-AS	hsa_circ_CDR1	CDR1	multiple myeloma / MM	MONDO:0009693	plasma cell myeloma	down-regulated	RT-qPCR	"ciRS-7 is down-regulated in MM CD138+ plasma cells versus SMM/MGUS, yet higher ciRS-7 within MM patients predicts worse PFS/OS and serves as an independent unfavorable prognostic biomarker. Mechanistically, it is discussed mainly as a miRNA sponge with predicted miRNA targets and enriched cancer-related pathways from in silico analyses."	0.5339
39158293	mBio	2024	Protein-coding circular RNA enhances antiviral immunity via JAK/STAT pathway in Drosophila.		circZfh1	dme_circ_Zfh1	Zfh1	Drosophila C virus infection	MONDO:0005120	Drosophila C virus infection	up-regulated	RT-qPCR; RNA-seq	"In DCV-infected Drosophila S2 cells and adult flies, circZfh1 is induced and restricts viral replication. circZfh1 encodes the antiviral protein CRAV, which promotes Upd3 expression and activates the JAK/STAT pathway, enhancing antiviral immunity particularly under viral suppression of antiviral RNAi."	0.7372
39159001	Biomolecules & biomedicine	2024	"Hsa_circ_0023179 modulated the processes of proliferation, apoptosis, and EMT in non-small cell lung cancer cells via the miR-615-5p/CDH3 axis."	hsa_circ_0023179	circ_0023179	hsa_circ_LRP5	LRP5	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0023179 is up-regulated in NSCLC tissues and cell lines and promotes NSCLC cell proliferation and EMT. Mechanistically, it acts as a miRNA sponge for miR-615-5p to de-repress CDH3, and circ_0023179 knockdown suppresses tumor growth in a nude mouse xenograft model."	0.8134
39161132	Journal of the Chinese Medical Association : JCMA	2024	Circular RNA LDLRAD3 promotes gastric cancer progression by upregulating COL4A5 through sponging miR-h37.	hsa_circ_0006988	circ-LDLRAD3 / circ-low-density lipoprotein receptor class A domain containing 3	hsa_circ_LDLRAD3	LDLRAD3	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ-LDLRAD3 is up-regulated in gastric cancer tissues and cell lines. It promotes malignant phenotypes (proliferation, migration, invasion, EMT) and suppresses apoptosis by sponging miR-137 to relieve repression of COL4A5."	0.7181
39164758	Molecular cancer	2024	Targeting circ-0034880-enriched tumor extracellular vesicles to impede SPP1highCD206+ pro-tumor macrophages mediated pre-metastatic niche formation in colorectal cancer liver metastasis.	hsa_circ_0034880	circ-0034880			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; RNA-seq; Microarray	"circ-0034880 is up-regulated/enriched in CRC patient plasma EVs and is further increased in CRC with liver metastasis. Tumor-derived EVs deliver circ-0034880 to liver macrophages, where it sponges miR-200a-3p and miR-141-3p to increase SPP1, promoting SPP1highCD206+ pro-tumor macrophage activation, PMN formation, and liver metastasis. Ginsenoside Rb1 inhibits circ-0034880 biogenesis via targeting the RBP QKI, reducing downstream macrophage activation and metastasis."	0.7471
39164758	Molecular cancer	2024	Targeting circ-0034880-enriched tumor extracellular vesicles to impede SPP1highCD206+ pro-tumor macrophages mediated pre-metastatic niche formation in colorectal cancer liver metastasis.	mmu_circ_0034880	circ-0034880			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; RNA-seq; Microarray	"circ-0034880 is up-regulated/enriched in CRC patient plasma EVs and is further increased in CRC with liver metastasis. Tumor-derived EVs deliver circ-0034880 to liver macrophages, where it sponges miR-200a-3p and miR-141-3p to increase SPP1, promoting SPP1highCD206+ pro-tumor macrophage activation, PMN formation, and liver metastasis. Ginsenoside Rb1 inhibits circ-0034880 biogenesis via targeting the RBP QKI, reducing downstream macrophage activation and metastasis."	0.7471
39164777	Biology direct	2024	hsa_circ_0020093 suppresses ovarian cancer progression by modulating LRPPRC activity and miR-107/LATS2 signaling.	hsa_circ_0020093	circATRNL1 / circ_0020093	hsa_circ_ATRNL1	ATRNL1	ovarian cancer / OC	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR	"hsa_circ_0020093 is down-regulated in ovarian cancer and acts as a tumor suppressor. It binds the mitochondrial protein LRPPRC to reduce mitochondrial mRNA levels/mitochondria abundance, and sponges miR-107 to upregulate LATS2, leading to increased YAP phosphorylation and reduced YAP activity, thereby inhibiting malignant behaviors and tumor growth."	0.8073
39167076	Clinical and translational medicine	2024	Circular RNA LIPH promotes pancreatic cancer glycolysis and progression through sponge miR-769-3p and interaction with GOLM1.	hsa_circ_0068398	circLIPH / circ_0068398	hsa_circ_LIPH	LIPH	pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"circLIPH (circ_0068398), derived from LIPH, is up-regulated in pancreatic cancer and promotes proliferation, migration/invasion, EMT and glycolysis. Mechanistically, it sponges miR-769-3p to increase GOLM1 and activate the PI3K/AKT/mTOR pathway, enhancing tumor progression in vitro and in xenograft models."	0.8279
39167432	Aging	2024	Circ_0006476 modulates macrophage apoptosis through the miR-3074-5p/DLL4 axis: implications for Notch signalling pathway regulation in cardiovascular disease.	hsa_circ_0006476	Circ_0006476			atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR; RNA-seq	"In nicotine-treated THP-1 macrophages (an in vitro atherosclerosis-related model), circ_0006476 is up-regulated and promotes macrophage apoptosis. Mechanistically, it functions as a ceRNA by sponging miR-3074-5p to increase DLL4 and activate Notch signalling (NICD/HES1), thereby driving apoptosis-related gene changes (BAX¡ü, BCL2¡ý)."	0.593
39170007	Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition	2024	[Molecular Mechanism of circVRK1 Regulating the Proliferation and Apoptosis of Acute Lymphoblastic Leukemia KOCL44 Cells by Targeting miR-4428].		circVRK1			acute lymphoblastic leukemia / ALL	MONDO:0004967	acute lymphoblastic leukemia	unknown	RT-qPCR	"In KOCL44 acute lymphoblastic leukemia cells, circVRK1 overexpression suppresses proliferation and promotes apoptosis. Mechanistically, circVRK1 binds/targets miR-4428 and downregulates miR-4428, and miR-4428 overexpression reverses circVRK1¡¯s effects."	0.5554
39170557	Heliyon	2024	The circular RNA circ_0001742 regulates colorectal carcinoma proliferation and migration via the MicroRNA-431-5p/ALG8 axis.	hsa_circ_0001742	circ_0001742	hsa_circ_SMO	SMO	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"circ_0001742 (hsa_circ_0001742) is up-regulated in CRC cells/tissues and promotes proliferation, migration/invasion, and metastasis while inhibiting apoptosis. It mainly localizes to the cytoplasm and acts as a ceRNA sponge for miR-431-5p to de-repress ALG8, forming the circ_0001742/miR-431-5p/ALG8 axis. High circ_0001742 expression is associated with poor overall survival in CRC patients."	0.8658
39180763	RNA biology	2024	HNRNPD regulates the biogenesis of circRNAs and the ratio of mRNAs to circRNAs for a set of genes.		circCDK1	hsa_circ_CDK1	CDK1	clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	down-regulated	RT-qPCR; RNA-seq	"In ccRCC, circCDK1 is decreased in tumor tissues, while HNRNPD modulates the linear splicing/backsplicing balance of the CDK1 locus. Altered circCDK1:CDK1 mRNA ratio reflects HNRNPD-dependent circRNA biogenesis control; circCDK1 itself showed no direct effect on cell cycle/apoptosis in functional assays reported."	0.7373
39180763	RNA biology	2024	HNRNPD regulates the biogenesis of circRNAs and the ratio of mRNAs to circRNAs for a set of genes.		circCPSF6	hsa_circ_CPSF6	CPSF6	clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	unknown	ISH	"circCPSF6 was used as an example circRNA showing increased signal upon HNRNPD depletion and physical association with HNRNPD (pulldown and RIP), supporting an HNRNPD_circRNA interaction in circRNA biogenesis regulation."	0.385
39180763	RNA biology	2024	HNRNPD regulates the biogenesis of circRNAs and the ratio of mRNAs to circRNAs for a set of genes.		circASCC3_1	hsa_circ_ASCC3	ASCC3	clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	unknown	ISH	"circASCC3_1 (circASCC3-1) was used as an example circRNA showing increased FISH signal upon HNRNPD knockout and direct association with HNRNPD by pulldown and RIP, supporting an HNRNPD-mediated inhibitory regulation of circRNA biogenesis."	0.385
39181116	Translational oncology	2024	CircCOCH plays a critical role in Hepatocellular carcinoma through modulating miR-450a and activating PI3K/mTOR pathway.	hsa_circ_0031431	circCOCH	hsa_circ_COCH	COCH	Hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circCOCH (hsa_circ_0031431), derived from the COCH gene, is up-regulated in HCC tissues and cell lines and mainly localized in the cytoplasm. It promotes HCC proliferation and metastatic phenotypes by sponging miR-450a to increase EGFR expression and activate the EGFR-driven PI3K/AKT/mTOR pathway; IGF2BP3 supports its biogenesis via binding flanking intronic sequences."	0.8412
39183343	Cell death & disease	2024	A novel protein encoded by circCOPA inhibits the malignant phenotype of glioblastoma cells and increases their sensitivity to temozolomide by disrupting the NONO-SFPQ complex.	hsa_circ_0008661	circCOPA	hsa_circ_COPA	COPA	glioblastoma / GBM	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR; Microarray	"circCOPA is down-regulated in glioblastoma and acts as a tumor suppressor mainly by encoding the peptide COPA-99aa via an IRES. COPA-99aa binds NONO and SFPQ to disrupt their complex, suppressing proliferation/migration/invasion and enhancing temozolomide-induced DNA damage, consistent with improved patient prognosis when circCOPA is high."	0.8141
39183944	"Research (Washington, D.C.)"	2024	Aggravated Ulcerative Colitis via circNlgn-Mediated Suppression of Nuclear Actin Polymerization.		circNlgn	hsa_circ_Nlgn	Nlgn	ulcerative colitis / UC	MONDO:0005101	ulcerative colitis	up-regulated	RT-qPCR; ISH; RNA-seq	"circNlgn is up-regulated in acute ulcerative colitis and aggravates colitis. It functions mainly by encoding the nuclear protein Nlgn173, which binds actin, blocks Arp2/3-mediated nuclear actin polymerization (via increased actin Tyr-53 phosphorylation), and thereby promotes epithelial apoptosis and suppresses proliferation; it is linked to reduced PIAS3 and activation of STAT3/NF-kappaB signaling."	0.7855
39191749	Cell death & disease	2024	Circ-0044539 promotes lymph node metastasis of hepatocellular carcinoma through exosomal-miR-29a-3p.	hsa_circ_0044539	circ-0044539	hsa_circ_COL1A1	COL1A1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circ-0044539 (hsa_circ_0044539, host gene COL1A1) is up-regulated in HCC with lymph node metastasis and promotes HCC proliferation, migration, invasion and LNM. Mechanistically, it sponges miR-29a-3p to increase VEGFA and activate the PI3K-AKT-mTOR/HIF-1alpha/CXCR4 cascade, and via a HIF-1alpha-dependent mechanism increases exosome secretion and exosomal miR-29a-3p transfer to PMN-MDSCs to suppress Hbp-1 and enhance immunosuppression in lymph nodes. Serum circ-0044539 is elevated in LNM cases, supporting its biomarker potential."	0.843
39192160	Cardiovascular toxicology	2024	Exosomes from Hypoxic Pretreatment ADSCs Ameliorate Cardiac Damage Post-MI via Activated circ-Stt3b/miR-15a-5p/GPX4 Signaling and Decreased Ferroptosis.	mmu_circ_0001852	circ-Stt3b	mmu_circ_Stt3b	Stt3b	myocardial infarction / MI	MONDO:0005068	myocardial infarction	down-regulated	RT-qPCR; RNA-seq	"In a mouse MI setting, exosomal circ-Stt3b (mmu_circ_0001852) from hypoxia-pretreated ADSCs protects cardiomyocytes and improves post-MI cardiac damage. Mechanistically, circ-Stt3b sponges miR-15a-5p to increase GPX4, thereby reducing ROS/inflammation, apoptosis, and ferroptosis."	0.6744
39192374	Hereditas	2024	The novel circFKBP8/miR-432-5p/E2F7 cascade functions as a regulatory network in breast cancer.	hsa_circ_0000915	circFKBP8 / circ_0000915	hsa_circ_FKBP8	FKBP8	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circFKBP8 (hsa_circ_0000915) is upregulated in breast cancer tissues and cells and promotes malignant phenotypes (proliferation, migration, invasion, and stemness) and xenograft tumor growth. Mechanistically, it acts as a ceRNA by sponging miR-432-5p to increase E2F7 expression, and high circFKBP8 expression correlates with poor overall survival."	0.8489
39193132	"Research (Washington, D.C.)"	2024	Circular RNA IGF1R Promotes Cardiac Repair via Activating beta-Catenin Signaling by Interacting with DDX5 in Mice after Ischemic Insults.	hsa_circ_0005035	circIGF1R / rnoCirc_000455	hsa_circ_Igf1r	Igf1r	acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR; RNA-seq	"circIGF1R is up-regulated after myocardial ischemic injury and in AMI patient plasma. It promotes cardiomyocyte proliferation and inhibits apoptosis, enhancing cardiac repair by binding DDX5, stabilizing DDX5 protein via reduced ubiquitin-proteasomal degradation, and activating Wnt/beta-catenin signaling to induce cyclin D1 and c-Myc."	0.8567
39193132	"Research (Washington, D.C.)"	2024	Circular RNA IGF1R Promotes Cardiac Repair via Activating beta-Catenin Signaling by Interacting with DDX5 in Mice after Ischemic Insults.	mmu_circ_0001582	circIGF1R / rnoCirc_000455	mmu_circ_Igf1r	Igf1r	acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR; RNA-seq	"circIGF1R is up-regulated after myocardial ischemic injury and in AMI patient plasma. It promotes cardiomyocyte proliferation and inhibits apoptosis, enhancing cardiac repair by binding DDX5, stabilizing DDX5 protein via reduced ubiquitin-proteasomal degradation, and activating Wnt/beta-catenin signaling to induce cyclin D1 and c-Myc."	0.8567
39198460	Scientific reports	2024	Functional elucidation of the EIF4A3-circR-4225-miR-507-TNFSF11 regulatory axis in LUAD and its role in tumor progression.		circR-4225 / circR-4425			lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"circR-4225 is up-regulated in LUAD tissues and promotes LUAD cell proliferation/viability while inhibiting apoptosis. Mechanistically, EIF4A3 promotes circR-4225 expression, and circR-4225 sponges miR-507 to up-regulate TNFSF11."	0.7552
39198845	Biology direct	2024	Gastrin-related circRNA_0017065 promotes the proliferation and metastasis of colorectal cancer through the miR-3174/RBFOX2 axis.	hsa_circ_0017065	circRNA_0017065 / circ_0017065	hsa_circ_GAST	GAST	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"circRNA_0017065 is up-regulated in colorectal cancer tissues and promotes CRC cell proliferation and migration/metastasis while inhibiting apoptosis in vitro and tumour growth in vivo. It mainly localizes to the cytoplasm and promotes CRC progression by sponging miR-3174, thereby increasing RBFOX2 expression (circRNA_0017065/miR-3174/RBFOX2 axis). High circ_0017065 expression correlates with invasive clinicopathological features."	0.8635
39201700	International journal of molecular sciences	2024	Circular RNA Profile in Atherosclerotic Disease: Regulation during ST-Elevated Myocardial Infarction.		circUBAC2	hsa_circ_UBAC2	UBAC2	ST-elevated myocardial infarction / STEMI	MONDO:0041656	ST-elevation myocardial infarction	down-regulated	RT-qPCR	"circUBAC2 is down-regulated in whole blood of STEMI patients at admission vs healthy controls and increases after PCI, with a more pronounced rise under tocilizumab. Higher circUBAC2 at admission correlates with lower peak troponin T and smaller final infarct size, suggesting potential biomarker relevance. Mechanistically, the study proposes a predicted ceRNA (miRNA sponging) role with associated changes in immune/apoptosis/mitochondrial-function-related mRNA targets."	0.7242
39201700	International journal of molecular sciences	2024	Circular RNA Profile in Atherosclerotic Disease: Regulation during ST-Elevated Myocardial Infarction.		circANKRD42	hsa_circ_ANKRD42	ANKRD42	ST-elevated myocardial infarction / STEMI	MONDO:0041656	ST-elevation myocardial infarction	unknown	RT-qPCR	"circANKRD42 is not different at admission in STEMI vs healthy controls, but higher admission levels correlate with lower peak troponin T. Tocilizumab treatment induces an increase in circANKRD42 at 3_7 days post-PCI. The study proposes a predicted ceRNA mechanism with changes in immune- and mitochondrial-function-related mRNA targets (e.g., VDAC1, SLAMF7, LETM2, LACC1)."	0.7242
39210348	Journal of nanobiotechnology	2024	Circ_0008315 promotes tumorigenesis and cisplatin resistance and acts as a nanotherapeutic target in gastric cancer.	hsa_circ_0008315	circ_0008315 / circRASGRF2	hsa_circ_RASGRF2	RASGRF2	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circ_0008315 (hsa_circ_0008315), derived from RASGRF2, is up-regulated in gastric cancer and further elevated in cisplatin-resistant models. It promotes proliferation, migration/invasion, EMT, metastasis, and cisplatin resistance by sponging miR-3666 to increase CPEB4 and stemness-associated phenotypes. High circ_0008315 expression is associated with worse OS/DFS and serves as a potential therapeutic (nanoparticle siRNA) target."	0.8933
39215345	Molecular cancer	2024	Targeting m7G-enriched circKDM1A prevents colorectal cancer progression.		circKDM1A	hsa_circ_KDM1A	KDM1A	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"In colorectal cancer, circKDM1A is up-regulated and promotes proliferation, migration/invasion, and metastasis while inhibiting apoptosis. METTL1-mediated m7G modification (GG motif-dependent) stabilizes circKDM1A, which sponges miR-147b-3p to upregulate PDK1 and activate the AKT pathway; high circKDM1A is associated with poor prognosis."	0.8941
39219022	Cell proliferation	2025	CircSMAD3 represses VSMC phenotype switching and neointima formation via promoting hnRNPA1 ubiquitination degradation.	hsa_circ_0003973	circSMAD3 / circRNA.19175	hsa_circ_SMAD3	SMAD3	vascular injury 	MONDO:0005385	vascular disorder	down-regulated	RT-qPCR; ISH; RNA-seq; Microarray	"circSMAD3 (SMAD3-derived; human homolog hsa_circ_0003973) is down-regulated in vascular injury and atherosclerotic plaques. It suppresses VSMC proliferation and phenotype switching and reduces injury-induced neointima formation. Mechanistically, it binds nuclear hnRNPA1 and WDR76 to promote hnRNPA1 ubiquitination/degradation, thereby modulating p53 pre-RNA splicing and activating p53gamma signaling."	0.8585
39219022	Cell proliferation	2025	CircSMAD3 represses VSMC phenotype switching and neointima formation via promoting hnRNPA1 ubiquitination degradation.			mmu_circ_SMAD3	SMAD3	vascular injury 	MONDO:0005385	vascular disorder	down-regulated	RT-qPCR; ISH; RNA-seq; Microarray	"circSMAD3 (SMAD3-derived; human homolog hsa_circ_0003973) is down-regulated in vascular injury and atherosclerotic plaques. It suppresses VSMC proliferation and phenotype switching and reduces injury-induced neointima formation. Mechanistically, it binds nuclear hnRNPA1 and WDR76 to promote hnRNPA1 ubiquitination/degradation, thereby modulating p53 pre-RNA splicing and activating p53gamma signaling."	0.8585
39220968	Heliyon	2024	Expression profile of circular RNAs in blood samples of Northern Chinese males with intracerebral hemorrhage shows downregulation of hsa-circ-0090829.	hsa_circ_0090829	hsa-circRNA-0090829			intracerebral hemorrhage / ICH	MONDO:0013792	intracerebral hemorrhage	down-regulated	RT-qPCR; Microarray	"In Northern Chinese male ICH patients, hsa-circ-0090829 is significantly down-regulated in blood and shows diagnostic potential (AUC 0.807). Mechanistically, it functions as a ceRNA by sponging miR-526b-5p, potentially affecting downstream target genes and pathways (e.g., neurotrophin signaling, MAPK signaling, long-term potentiation)."	0.5963
39223162	Cell death discovery	2024	cirSIRT5 induces ferroptosis in bladder cancer by forming a ternary complex with SYVN1/PHGDH.	hsa_circ_0075648	circSIRT5	hsa_circ_SIRT5	SIRT5	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR	"circSIRT5 (hsa_circ_0075648) is down-regulated in bladder cancer and acts as a tumor suppressor. It binds PHGDH and recruits the E3 ligase SYVN1 to form a ternary complex, enhancing PHGDH ubiquitination and proteasomal degradation, thereby promoting ferroptosis and inhibiting tumor growth and metastasis."	0.8913
39224358	Heliyon	2024	The role of m6A modified circ0049271 induced by MNNG in precancerous lesions of gastric cancer.	hsa_circ_0049271	circ0049271	hsa_circ_KEAP1	KEAP1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circ0049271 is up-regulated in MNNG-induced malignant transformation of gastric epithelial cells and promotes proliferation, migration, invasion and EMT. It activates TGFbeta/SMAD signaling, and its m6A modification is proposed to be mediated by WTAP with an IGF2BP3-associated mechanism."	0.7006
39225900	Discover oncology	2024	Hsa_circYARS interacts with miR-29a-3p to up-regulate IREB2 and promote laryngeal squamous cell carcinoma progression.		circYARS	hsa_circ_YARS	YARS	laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR	"circYARS is up-regulated in LSCC tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion, EMT) while inhibiting apoptosis. Mechanistically, circYARS functions as a ceRNA that sponges miR-29a-3p to de-repress/up-regulate IREB2, and its high expression is associated with shorter overall survival."	0.8655
39229520	Heliyon	2024	CircRAPGEF5 acts as a modulator of RAS/RAF/MEK/ERK signaling during colorectal carcinogenesis.		circRAPGEF5	hsa_circ_RAPGEF5	RAPGEF5	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"circRAPGEF5 is up-regulated in colorectal cancer, especially in KRAS-mutant CRC cells, and promotes CRC cell proliferation by preventing apoptosis. Mechanistically, circRAPGEF5 restrains RAS/RAF/MEK/ERK signaling to avoid hyperactivation, thereby suppressing TNFRSF10A induction and apoptosis; EIF4A3 enhances circRAPGEF5 biogenesis by promoting its circularization."	0.8166
39229655	"Cancer reports (Hoboken, N.J.)"	2024	CircFAM188A Regulates Autophagy via miR-670-3p and ULK1 in Epithelial Ovarian Carcinoma.		circFAM188A / circ_FAM188A	hsa_circ_FAM188A	FAM188A	epithelial ovarian cancer / EOC	MONDO:0005140	ovarian carcinoma	up-regulated	RT-qPCR	"circFAM188A is up-regulated in epithelial ovarian cancer tissues and promotes EOC cell proliferation and invasion. It enhances autophagy mainly by sponging miR-670-3p to upregulate YY1 and by directly interacting with ULK1, leading to increased autophagic flux and xenograft tumor growth."	0.8455
39229866	Renal failure	2024	CircPWWP2A promotes renal interstitial fibrosis through modulating miR-182/ROCK1 axis.	hsa_circ_0074837	circPWWP2A	hsa_circ_PWWP2A	PWWP2A	renal interstitial fibrosis	MONDO:0000494	renal fibrosis	up-regulated	RT-qPCR; ISH	"circPWWP2A is up-regulated in UUO kidney and TGF-beta-treated renal tubular cells and acts as a pro-fibrotic circRNA. It promotes mtROS production and mitochondrial dysfunction, and mechanistically functions as a ceRNA that sponges miR-182 to increase ROCK1, thereby aggravating renal interstitial fibrosis."	0.6722
39232183	Scientific reports	2024	The study on circRNA profiling uncovers the regulatory function of the hsa_circ_0059665/miR-602 pathway in breast cancer.	hsa_circ_0059665		hsa_circ_ABHD12	ABHD12	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; ISH; Microarray	"hsa_circ_0059665 is down-regulated in breast cancer tissues and mainly localizes in the cytoplasm. It suppresses breast cancer cell proliferation, migration, and invasion by sponging miR-602, and low expression is associated with poor patient prognosis."	0.8645
39235443	eLife	2024	Circular RNA HMGCS1 sponges MIR4521 to aggravate type 2 diabetes-induced vascular endothelial dysfunction.	hsa_circ_0008621	circHMGCS1	hsa_circ_HMGCS1	HMGCS1	type 2 diabetes / T2DM	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RT-qPCR; RNA-seq	"circHMGCS1 is up-regulated in diabetes-associated endothelial dysfunction models and promotes vascular endothelial dysfunction. It functions as a cytoplasmic ceRNA that sponges MIR4521, thereby increasing ARG1 expression, reducing NO production and ENOS activity, and enhancing ROS generation and adhesion molecule expression in vitro and in HFHG diet-induced diabetic mice."	0.8166
39237880	Cellular & molecular biology letters	2024	Hsa_circ_0000520 suppresses vasculogenic mimicry formation and metastasis in bladder cancer through Lin28a/PTEN/PI3K signaling.	hsa_circ_0000520		hsa_circ_RPPH1	RPPH1	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; ISH; RNA-seq	"hsa_circ_0000520 is downregulated in bladder cancer and functions as a tumor suppressor by inhibiting invasion, migration, vasculogenic mimicry, and metastasis. It acts as a cytoplasmic scaffold to promote UBE2V1/UBC13-mediated ubiquitination and degradation of Lin28a, increasing PTEN mRNA stability and suppressing PI3K/AKT/mTOR signaling; its biogenesis is promoted by QKI."	0.8814
39243066	Journal of cardiothoracic surgery	2024	Abnormal expression of circ_0013958 in patients with acute myocardial infarction (AMI) and its influence on prognosis.	hsa_circ_0013958	circ_0013958 / circ0013958			acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR; Microarray	"circ_0013958 is up-regulated in AMI patient plasma and shows diagnostic value (ROC AUC 0.908). Higher circ_0013958 is associated with greater disease severity indicators and independently predicts AMI occurrence, MACEs, and poorer survival during follow-up."	0.5734
39247600	Journal of Cancer	2024	circTP63 promotes prostate cancer progression via miR-421/VAMP associated protein A axis.		circTP63	hsa_circ_TP63	TP63	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circTP63 is up-regulated in prostate cancer tissues/cell lines and mainly localizes to the cytoplasm. It promotes PCa proliferation and metastatic behaviors and inhibits apoptosis by sponging miR-421 to de-repress VAPA, enhancing tumor growth in a PC-3 xenograft model."	0.8568
39253079	Frontiers in immunology	2024	CircRNAs expression profile and potential roles of circRERE-PMN in pre-metastatic lungs.		circ:chr4:150406196_150406664 (circRERE-PMN)	mmu_circ_RERE	RERE	pre-metastatic niche	MONDO:0024883	metastatic neoplasm	up-regulated	RT-qPCR; RNA-seq	"circRERE-PMN is up-regulated in mouse pre-metastatic lung tissue and is enriched in MDSCs, macrophages, and especially alveolar epithelial cells, mainly in the cytoplasm. In alveolar epithelial cells, circRERE-PMN inhibits apoptosis and promotes expression of PMN-associated cytokines/chemokines (e.g., S100A8/A9, CXCL1/2, Bv8, MMP9), potentially via interaction with the RBP HUR."	0.5307
39253079	Frontiers in immunology	2024	CircRNAs expression profile and potential roles of circRERE-PMN in pre-metastatic lungs.		circ:chr19:38523915 _ 38525452 (circPLCE1-PMN)	mmu_circ_PLCE1	PLCE1	pre-metastatic niche	MONDO:0024883	metastatic neoplasm	up-regulated	RT-qPCR; RNA-seq	"circPLCE1-PMN is up-regulated in mouse pre-metastatic lung tissue compared with normal lung, supported by RNA-seq and RT-qPCR validation; no downstream mechanism was characterized in this study."	0.3213
39253079	Frontiers in immunology	2024	CircRNAs expression profile and potential roles of circRERE-PMN in pre-metastatic lungs.		circ:chr9:76996893 _ 77027004 (circTINAG-PMN)	mmu_circ_TINAG	TINAG	pre-metastatic niche	MONDO:0024883	metastatic neoplasm	up-regulated	RT-qPCR; RNA-seq	"circTINAG-PMN is up-regulated in mouse pre-metastatic lung tissue compared with normal lung, supported by RNA-seq and RT-qPCR validation; no downstream mechanism was characterized in this study."	0.3213
39253079	Frontiers in immunology	2024	CircRNAs expression profile and potential roles of circRERE-PMN in pre-metastatic lungs.		circ:chr4:126814256 _ 126816474 (circAU040320-PMN)	mmu_circ_AU040320	AU040320	pre-metastatic niche	MONDO:0024883	metastatic neoplasm	down-regulated	RT-qPCR; RNA-seq	"circAU040320-PMN is down-regulated in mouse pre-metastatic lung tissue compared with normal lung, supported by RNA-seq and RT-qPCR validation; no downstream mechanism was characterized in this study."	0.3213
39258752	Cancer biology & therapy	2024	CircBIRC6 affects prostate cancer progression by regulating miR-574-5p and DNAJB1.	hsa_circ_0119816	circBIRC6 / circ_0119816	hsa_circ_BIRC6	BIRC6	Prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"CircBIRC6 (hsa_circ_0119816) is up-regulated in prostate cancer and mainly localizes to the cytoplasm. It promotes malignant phenotypes (proliferation, invasion, EMT, and autophagy) and inhibits apoptosis, at least partly through the circBIRC6/miR-574-5p/DNAJB1 regulatory axis."	0.7449
39261936	European journal of medical research	2024	Value of CDR1-AS as a predictive and prognostic biomarker for patients with breast cancer receiving neoadjuvant chemotherapy in a prospective Chinese cohort.	hsa_circ_0001946	CDR1-AS	hsa_circ_CDR1	CDR1	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	"In a prospective Chinese cohort of locally advanced breast cancer treated with paclitaxel-cisplatin neoadjuvant chemotherapy, CDR1-AS expression in pretreatment tumor tissue was associated with treatment response and prognosis. Lower CDR1-AS expression predicted higher pCR rates, while higher CDR1-AS expression was associated with better DFS/RFS/DDFS; no mechanism was experimentally established in this work."	0.5339
39262484	Translational cancer research	2024	Has_circ_0002360 promotes the progression of lung adenocarcinoma by activating miR-762 and regulating PODXL expression.	hsa_circ_0002360	circ_0002360			lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"has_circ_0002360 is overexpressed in lung adenocarcinoma tissues and cell lines and promotes proliferation, migration, invasion and EMT. It functions as a ceRNA by sponging miR-762, thereby relieving repression of PODXL and driving LAC progression."	0.8166
39272146	Journal of nanobiotechnology	2024	Circ_0001947 encapsulated by small extracellular vesicles promotes gastric cancer progression and anti-PD-1 resistance by modulating CD8+ T cell exhaustion.	hsa_circ_0001947	circ_0001947 / circ0001947	hsa_circ_AFF2	AFF2	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	circ_0001947 (circAFF2) is up-regulated in gastric cancer and enriched in GC-derived sEVs. It promotes tumor cell proliferation/migration/invasion and drives CD8+ T cell exhaustion and anti-PD-1 resistance by sponging miR-661/miR-671-5p to increase CD39 (ENTPD1).	0.8823
39272989	Cells	2024	Postoperative Organ Dysfunction Risk Stratification Using Extracellular Vesicle-Derived circRNAs in Pediatric Congenital Heart Surgery.		circ-CELSR1	hsa_circ_CELSR1	CELSR1	respiratory failure	MONDO:0021113	respiratory failure	down-regulated	RNA-seq	"EV-derived circ-CELSR1 in plasma is reduced in patients who develop postoperative organ/respiratory dysfunction and correlates with PELOD score, suggesting prognostic value. It is discussed as potentially acting via miR-598 sponging in the context of lung injury/repair biology."	0.348
39272989	Cells	2024	Postoperative Organ Dysfunction Risk Stratification Using Extracellular Vesicle-Derived circRNAs in Pediatric Congenital Heart Surgery.		circ-PLXNA1	hsa_circ_PLXNA1	PLXNA1	respiratory failure	MONDO:0021113	respiratory failure	down-regulated	RNA-seq	"EV-derived circ-PLXNA1 is reduced in postoperative OD/respiratory dysfunction and is part of a circRNA panel correlated with PELOD score (AUC 0.95). It is discussed as potentially sponging miR-214, whereby reduced circ-PLXNA1 could worsen lung injury."	0.348
39272989	Cells	2024	Postoperative Organ Dysfunction Risk Stratification Using Extracellular Vesicle-Derived circRNAs in Pediatric Congenital Heart Surgery.		circ-OBSL1	hsa_circ_OBSL1	OBSL1	respiratory failure	MONDO:0021113	respiratory failure	down-regulated	RNA-seq	EV-derived circ-OBSL1 is reduced in postoperative OD/respiratory dysfunction and is included in a 5-circRNA panel correlated with PELOD score with high ROC performance (AUC 0.95). No specific miRNA/molecular mechanism is reported for circ-OBSL1 in this study.	0.348
39272989	Cells	2024	Postoperative Organ Dysfunction Risk Stratification Using Extracellular Vesicle-Derived circRNAs in Pediatric Congenital Heart Surgery.		circ-DAB2IP	hsa_circ_DAB2IP	DAB2IP	respiratory failure	MONDO:0021113	respiratory failure	down-regulated	RNA-seq	EV-derived circ-DAB2IP is reduced in postoperative OD/respiratory dysfunction and is included in a 5-circRNA panel correlated with PELOD score with high ROC performance (AUC 0.95). The study does not report a specific mechanism for circ-DAB2IP.	0.348
39272989	Cells	2024	Postoperative Organ Dysfunction Risk Stratification Using Extracellular Vesicle-Derived circRNAs in Pediatric Congenital Heart Surgery.		circ-KANK1	hsa_circ_KANK1	KANK1	respiratory failure	MONDO:0021113	respiratory failure	down-regulated	RNA-seq	EV-derived circ-KANK1 is reduced in postoperative OD/respiratory dysfunction and is included in a 5-circRNA panel correlated with PELOD score with high ROC performance (AUC 0.95). The study does not report a specific mechanism for circ-KANK1.	0.348
39281569	Heliyon	2024	circ_0114866 promotes the progression and EMT of non-small cell lung cancer via miR-653-5p/MYL6B axis.	hsa_circ_0114866	circ_0114866 / circ-0114866	hsa_circ_ZNF337	ZNF337	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0114866 is up-regulated in NSCLC tissues and cell lines and mainly localizes to the cytoplasm. It promotes NSCLC malignant phenotypes (proliferation, migration/invasion, EMT, and xenograft tumor growth) by acting as a ceRNA that sponges miR-653-5p to increase MYL6B expression."	0.7859
39287101	Journal of radiation research	2024	"Regulation of a novel circATP8B4/miR-31-5p/nestin ceRNA crosstalk in proliferation, motility, invasion and radiosensitivity of human glioma cells."	hsa_circ_0035199	circATP8B4	hsa_circ_ATP8B4	ATP8B4	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circATP8B4 is up-regulated in human glioma and promotes malignant phenotypes (proliferation, motility, invasion/EMT) while reducing radiosensitivity. It acts as a ceRNA sponge for miR-31-5p to upregulate NES, and circATP8B4 knockdown suppresses xenograft growth and enhances radiotherapy efficacy."	0.8443
39289194	Cell biology and toxicology	2024	TRMT10C-mediated m7G modification of circFAM126A inhibits lung cancer growth by regulating cellular glycolysis.	hsa_circ_0005251	circFAM126A	hsa_circ_FAM126A	FAM126A	lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR; Microarray	"circFAM126A (hsa_circ_0005251) is down-regulated in lung cancer tissues and cell lines. Functionally, it suppresses lung cancer proliferation and migration and promotes apoptosis in vitro and inhibits tumor growth in a xenograft model. Mechanistically, TRMT10C-mediated m7G modification increases circFAM126A stability, and circFAM126A binds HSP90 to promote its ubiquitination, reducing AKT1 signaling and glycolysis."	0.8803
39289683	"Journal of inflammation (London, England)"	2024	Circ_001653 alleviates sepsis associated-acute kidney injury by recruiting BUD13 to regulate KEAP1/NRF2/HO-1 signaling pathway.		circ_001653	hsa_circ_DUSP22	DUSP22	sepsis-associated acute kidney injury	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR	"circ_001653 is up-regulated in SA-AKI models (LPS-stimulated HK-2 cells and CLP-induced rat kidney). Silencing circ_001653 protects against SA-AKI phenotypes by reducing apoptosis, oxidative stress and inflammation. Mechanistically, circ_001653 recruits the RBP BUD13 to stabilize KEAP1 mRNA and modulate the KEAP1/Nrf2/HO-1 signaling pathway."	0.7346
39290984	Frontiers in genetics	2024	Construction of circRNA-mediated ceRNA network and immunoassay for investigating pathogenesis of COPD.		circDTL	hsa_circ_DTL	DTL	chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR	"The study proposes and supports a ceRNA axis in COPD in which circDTL is upregulated and sponges hsa-miR-330-3p, leading to increased CCL20 expression. This axis is linked to inflammatory/immune responses in the COPD cell model."	0.3963
39293372	"Clinics (Sao Paulo, Brazil)"	2024	Circular RNA circRNA_100349 functions as a miR-218-5p sponge for suppressing the cell proliferation of gastric cancer via regulation of IGF2 expression.		circRNA_100349			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circRNA_100349 is up-regulated in gastric cancer tissues and cell lines, and high expression is associated with poor overall survival and diagnostic value. Functionally, circRNA_100349 promotes gastric cancer proliferation and tumor growth by sponging miR-218_5p to increase IGF2 expression; its knockdown suppresses proliferation in vitro and xenograft growth in vivo."	0.7969
39300219	Cancer gene therapy	2024	Chronic stress promotes non-small cell lung cancer (NSCLC) progression through circMBOAT2 upregulation mediated by CTCF.		circMBOAT2 / MMU_CIRCpedia_14285	hsa_circ_MBOAT2	MBOAT2	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circMBOAT2 is up-regulated in NSCLC cells and tumor tissues and functions as an oncogenic circRNA that promotes proliferation, migration, invasion, and in vivo tumor growth, particularly under chronic stress/NE conditions. The study supports an upstream regulatory relationship where stress-induced CTCF increases circMBOAT2 expression, and ASO-mediated silencing of circMBOAT2 suppresses tumor growth."	0.7654
39304860	BMC cancer	2024	"Hsa_circ_0006010 and hsa_circ_0002903 in peripheral blood serve as novel diagnostic, surveillance and prognostic biomarkers for disease progression in chronic myeloid leukemia."	hsa_circ_0006010		hsa_circ_DPY19L1P1	DPY19L1P1	chronic myeloid leukemia / CML	MONDO:0011996	"chronic myelogenous leukemia, BCR-ABL1 positive"	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0006010 is up-regulated in peripheral blood during CML progression (advanced CML/AP-BP vs CP/HCs). Its level in PBMCs measured by qRT-PCR shows diagnostic ability for disease progression and can monitor remission status, and higher expression is associated with worse progression-free survival."	0.5534
39304860	BMC cancer	2024	"Hsa_circ_0006010 and hsa_circ_0002903 in peripheral blood serve as novel diagnostic, surveillance and prognostic biomarkers for disease progression in chronic myeloid leukemia."	hsa_circ_0002903		hsa_circ_PCNT	PCNT	chronic myeloid leukemia / CML	MONDO:0011996	"chronic myelogenous leukemia, BCR-ABL1 positive"	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0002903 is down-regulated in peripheral blood during CML progression (advanced CML/AP-BP vs CP/HCs). Its qRT-PCR level has diagnostic value for identifying disease progression and changes with remission, and lower expression is associated with worse progression-free survival."	0.5534
39307884	Journal of cellular and molecular medicine	2024	Inhibition of circular JUN prevents the proliferation and invasion of glioblastoma via miR-3064-IGFBP5 axis.	hsa_circ_0000074	circJUN	hsa_circ_JUN	JUN	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; RNA-seq	"circJUN (hsa_circ_0000074), derived from JUN, is overexpressed in glioblastoma and mainly localized in the cytoplasm. It promotes GBM cell proliferation, migration/invasion, and xenograft tumour growth by sponging miR-3064 to de-repress IGFBP5, while EIF4A3 binds circJUN and enhances its expression; high circJUN is associated with poor survival."	0.8844
39310105	Theranostics	2024	Dual role of exosomal circCMTM3 derived from GSCs in impeding degradation and promoting phosphorylation of STAT5A to facilitate vasculogenic mimicry formation in glioblastoma.	hsa_circ_0008450	circCMTM3	hsa_circ_CMTM3	CMTM3	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; RNA-seq	"Exosomal circCMTM3 is up-regulated in glioblastoma and is associated with higher glioma grade and poor prognosis. It promotes proliferation, invasion/migration, and vasculogenic mimicry in differentiated glioma cells by binding CNOT4 to inhibit STAT5A/STAT5B ubiquitination-degradation and by scaffolding JAK2-STAT5 signaling to enhance STAT5A phosphorylation, inducing CHI3L2 and SRSF1 and sustaining a circCMTM3/STAT5A/SRSF1 positive feedback loop."	0.8969
39310771	iScience	2024	CircPOLA2 sensitizes non-small cell lung cancer cells to ferroptosis and suppresses tumorigenesis via the Merlin-YAP signaling pathway.	hsa_circ_0004291	circPOLA2	hsa_circ_POLA2	POLA2	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	"circPOLA2 (hsa_circ_0004291) is down-regulated in NSCLC and acts as a tumor suppressor by promoting lipid peroxidation/ferroptosis and inhibiting proliferation and metastasis-related behaviors. Mechanistically, it binds Merlin, reduces Merlin Ser518 phosphorylation, activates Hippo signaling and suppresses YAP activity, increasing ferroptosis sensitivity and inhibiting tumor growth."	0.8832
39317735	Scientific reports	2024	circ_SMA4 promotes gastrointestinal stromal tumors malignant progression by sponging miR-494-3p/KIT axis and activating JAK/STAT pathway.	hsa_circ_0072805	circ_SMA4 / hsa_circRNA_103870	hsa_circ_SMA4	SMA4	Gastrointestinal stromal tumor / GIST	MONDO:0011719	gastrointestinal stromal tumor	up-regulated	RT-qPCR; Microarray	"circ_SMA4 is up-regulated in GISTs and functions as an oncogenic circRNA. It promotes proliferation, invasion and migration and inhibits apoptosis by acting as a ceRNA that sponges miR-494-3p, thereby upregulating KIT and activating the KIT/JAK/STAT pathway; it also shows strong diagnostic potential (high AUC)."	0.7739
39319166	Heliyon	2024	Hsa_circ_0000825 promotes the progression of laryngeal squamous cell carcinoma by sponging miR-766 and interacting with ELAVL1.	hsa_circ_0000825		hsa_circ_MTCL1	MTCL1	laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000825 is up-regulated in LSCC tissues and promotes LSCC cell proliferation, migration, invasion, and xenograft tumor growth. It functions mainly in the cytoplasm by sponging miR-766 to enhance HOXD10 expression and by interacting with the RBP ELAVL1 to support pro-oncogenic effects, and its high expression is associated with poor overall survival."	0.8769
39328024	CNS neuroscience & therapeutics	2024	Physical exercise-induced circAnks1b upregulation promotes protective endoplasmic reticulum stress and suppresses apoptosis via miR-130b-5p/Pak2 signaling in an ischemic stroke model.	hsa_circ_0096921	circAnks1b / hsa-circAnks1b	hsa_circ_ANKS1B	Anks1b	ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; RNA-seq	"In tMCAO ischemic stroke models, physical exercise upregulates circAnks1b in peri-infarct cortex. circAnks1b sponges miR-130b-5p to relieve repression of Pak2, enhancing IRE1alpha/XBP1-associated protective ER stress and suppressing neuronal apoptosis, improving neurological recovery. Plasma circAnks1b increases with exercise in IS patients and is associated with better functional outcome."	0.8484
39328024	CNS neuroscience & therapeutics	2024	Physical exercise-induced circAnks1b upregulation promotes protective endoplasmic reticulum stress and suppresses apoptosis via miR-130b-5p/Pak2 signaling in an ischemic stroke model.			rno_circ_Anks1b	Anks1b	ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; RNA-seq	"In tMCAO ischemic stroke models, physical exercise upregulates circAnks1b in peri-infarct cortex. circAnks1b sponges miR-130b-5p to relieve repression of Pak2, enhancing IRE1alpha/XBP1-associated protective ER stress and suppressing neuronal apoptosis, improving neurological recovery. Plasma circAnks1b increases with exercise in IS patients and is associated with better functional outcome."	0.8484
39329212	International journal of oncology	2024	MEF2A is a transcription factor for circPVT1 and contributes to the malignancy of acute myeloid leukemia.	hsa_circ_0085536	circPVT1	hsa_circ_PVT1	PVT1	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"circPVT1 is up-regulated in AML plasma and AML cell lines. MEF2A increases circPVT1 expression via promoter activation, and circPVT1 promotes AML cell viability and EMT and suppresses apoptosis by sponging miR-455-3p to upregulate MCL1."	0.7551
39329462	Journal of extracellular vesicles	2024	Integrin alpha6-containing extracellular vesicles promote lymphatic remodelling for pre-metastatic niche formation in lymph nodes via interplay with CD151.	hsa_circ_0045334	circRNA-LIPAR / LIPAR	hsa_circ_PLEKHM1P	PLEKHM1P	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; RNA-seq	"In bladder cancer, LIPAR (hsa_circ_0045334; host gene PLEKHM1P) is enriched in ITGA6+ extracellular vesicles and is delivered to lymphatic endothelial cells. LIPAR promotes SELE transcription (via promoter binding and p300/H3K9ac) to induce lymphatic remodelling pre-metastatic niche formation in draining lymph nodes, facilitating lymphatic metastasis, and high urinary EV LIPAR associates with poor prognosis."	0.8936
39333496	Cell death & disease	2024	CircSEC24B activates autophagy and induces chemoresistance of colorectal cancer via OTUB1-mediated deubiquitination of SRPX2.	hsa_circ_0001436	circSEC24B	hsa_circ_SEC24B	SEC24B	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"circSEC24B (hsa_circ_0001436) is upregulated in colorectal cancer tissues and cell lines and promotes proliferation, autophagy activation, and oxaliplatin chemoresistance. Mechanistically, it acts as a scaffold enhancing OTUB1_SRPX2 interaction to reduce SRPX2 ubiquitination and stabilize SRPX2 protein."	0.8535
39333871	Cellular & molecular biology letters	2024	A novel protein SPECC1-415aa encoded by N6-methyladenosine modified circSPECC1 regulates the sensitivity of glioblastoma to TMZ.	hsa_circ_0000745	circSPECC1 / circ_0000745	hsa_circ_SPECC1	SPECC1	glioblastoma / GBM	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR; Microarray	"circSPECC1 (hsa_circ_0000745), derived from SPECC1, is down-regulated in recurrent GBM and TMZ-resistant GBM cells. It suppresses malignant phenotypes and restores TMZ sensitivity mainly by encoding the peptide SPECC1-415aa, which binds ANXA2 and blocks ANXA2_EGFR interaction, thereby inhibiting EGFR/AKT signaling; IGF2BP1 binding (m6A-dependent) promotes circSPECC1 stability."	0.8886
39334380	Molecular cancer	2024	Circular RNA-encoded oncogenic PIAS1 variant blocks immunogenic ferroptosis by modulating the balance between SUMOylation and phosphorylation of STAT1.	hsa_circ_0008378	circPIAS1	hsa_circ_PIAS1	Pias1	melanoma	MONDO:0005105	melanoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circPIAS1 is upregulated in melanoma tumors and promotes tumor cell proliferation while limiting PD-1 blockade efficacy. It encodes a 108-aa peptide that recruits Ranbp2 to increase STAT1 SUMOylation, suppress STAT1 phosphorylation, reactivate SLC7A11/GPX4, and inhibit IFNgamma-induced immunogenic ferroptosis."	0.8354
39334380	Molecular cancer	2024	Circular RNA-encoded oncogenic PIAS1 variant blocks immunogenic ferroptosis by modulating the balance between SUMOylation and phosphorylation of STAT1.	mmu_circ_0015773	circPIAS1	mmu_circ_PIAS1	Pias1	melanoma	MONDO:0005105	melanoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circPIAS1 is upregulated in melanoma tumors and promotes tumor cell proliferation while limiting PD-1 blockade efficacy. It encodes a 108-aa peptide that recruits Ranbp2 to increase STAT1 SUMOylation, suppress STAT1 phosphorylation, reactivate SLC7A11/GPX4, and inhibit IFNgamma-induced immunogenic ferroptosis."	0.8354
39342185	Molecular cancer	2024	CircLIFRSA/miR-1305/PTEN axis attenuates malignant cellular processes in non-small cell lung cancer by regulating AKT phosphorylation.	hsa_circ_0072298	circLIFRSA	hsa_circ_LIFRSA	LIFRSA	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"circLIFRSA (hsa_circ_0072298), derived from LIFRSA, is down-regulated in NSCLC tissues and cell lines and mainly localizes to the cytoplasm. It suppresses malignant phenotypes by sponging miR-1305 to relieve repression of PTEN, thereby reducing AKT phosphorylation, inhibiting growth/proliferation and promoting apoptosis. Blood circLIFRSA shows diagnostic potential for distinguishing lung cancer/NSCLC from benign lung disease."	0.8252
39342367	Journal of cardiothoracic surgery	2024	Hsa_circ_0079929 in lung adenocarcinoma and its biological implications in lung adenocarcinoma progression.	hsa_circ_0079929	hsa_circCDK13_005 / CircCDK13	hsa_circ_CDK13	CDK13	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"hsa_circ_0079929 is up-regulated in lung adenocarcinoma tissues and cell lines and correlates with advanced clinicopathologic features and worse overall survival. Functionally, it promotes proliferation, migration, and invasion in LUAD cells. Mechanistically, it acts as a miR-1184 sponge/decoy, and miR-1184 inhibition rescues the effects of hsa_circ_0079929 knockdown."	0.7785
39354521	Journal of translational medicine	2024	Radiation-sensitive circRNA hsa_circ_0096498 inhibits radiation-induced liver fibrosis by suppressing EIF4A3 nuclear translocation to decrease CDC42 expression in hepatic stellate cells.	hsa_circ_0096498	circ96498	hsa_circ_RSF1	RSF1	radiation-induced liver fibrosis / RILF	MONDO:0043459	radiation-induced disorder	up-regulated	RT-qPCR; ISH	"hsa_circ_0096498 (circ96498), derived from RSF1, is up-regulated in irradiated hepatic stellate cells in radiation-induced liver injury/fibrosis. It binds EIF4A3 to prevent its nuclear translocation, lowering CDC42 mRNA stability and CDC42 expression, thereby inhibiting NF-kappaB and JNK/Smad2 signaling and suppressing inflammatory/fibrotic activation of HSCs and RILF progression."	0.8416
39354521	Journal of translational medicine	2024	Radiation-sensitive circRNA hsa_circ_0096498 inhibits radiation-induced liver fibrosis by suppressing EIF4A3 nuclear translocation to decrease CDC42 expression in hepatic stellate cells.	mmu_circ_0013678	circ13678			radiation-induced liver fibrosis / RILF	MONDO:0043459	radiation-induced disorder	up-regulated	RT-qPCR	"In the irradiated mouse liver fibrosis model, the conserved circRNA mmu_circ_0013678 (circ13678) is induced by irradiation in HSCs. circ13678 knockdown worsens liver fibrosis and inflammatory responses, and is associated with increased EIF4A3 nuclear translocation and elevated CDC42; pharmacologic CDC42 inhibition mitigates these effects."	0.6261
39354535	Respiratory research	2024	CircSSR1 regulates pyroptosis of pulmonary artery smooth muscle cells through parental protein SSR1 mediating endoplasmic reticulum stress.			hsa_circ_SSR1	SSR1	pulmonary hypertension / PH	MONDO:0005149	pulmonary hypertension	down-regulated	RT-qPCR	"circSSR1 is down-regulated in hypoxic PASMCs in pulmonary hypertension models. It interacts with YTHDF1 and affects m6A-dependent SSR1 translation to modulate ER stress and pyroptosis, while G3BP1 promotes circSSR1 degradation under hypoxia. Overexpression of circSSR1 alleviates hypoxia-induced pyroptosis and pulmonary vascular remodeling in vivo."	0.7659
39359616	International journal of general medicine	2024	Circular RNA circEZH2 Promotes Lung Adenocarcinoma Progression by Regulating microRNA-495-3p/Tumor Protein D52 Axis and Activating Nuclear Factor-Kappa B Pathway.	hsa_circ_0006357	circEZH2	hsa_circ_EZH2	EZH2	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circEZH2 (hsa_circ_0006357) is up-regulated in LUAD tissues and cell lines and promotes proliferation, migration, invasion and EMT, enhancing xenograft tumor growth. Mechanistically, it functions as a ceRNA by sponging miR-495-3p to upregulate TPD52, leading to activation of the NF-kappaB pathway."	0.8254
39366935	Cell death discovery	2024	CircGSK3beta mediates PD-L1 transcription through miR-338-3p/PRMT5/H3K4me3 to promote breast cancer cell immune evasion and tumor progression.	hsa_circ_0008797	circGSK3beta / circGSK3B	hsa_circ_GSK3beta	GSK3beta	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circGSK3beta is upregulated in breast cancer cell lines and promotes proliferation, migration, and invasion. It acts as a ceRNA by sponging miR-338-3p to increase PRMT5, which enhances H3K4me3 at the PD-L1 promoter and upregulates PD-L1, leading to immune evasion via impaired CD8+ T-cell function."	0.8278
39366979	Nature communications	2024	Human papillomavirus-encoded circular RNA circE7 promotes immune evasion in head and neck squamous cell carcinoma.		circE7			head and neck squamous cell carcinoma / HNSCC	MONDO:0010150	head and neck squamous cell carcinoma	up-regulated	RT-qPCR; ISH	"In HPV16+ HNSCC, circE7 is present mainly in tumors and promotes immune evasion by impairing CD8+ T cell infiltration and cytotoxic activity. Mechanistically, circE7 binds and activates ACC1, lowering acetyl-CoA and H3K27ac at the LGALS9 promoter to suppress galectin-9, which in turn modulates TIM-3/PD-1-related T cell function and apoptosis. Combination anti-PD-1 plus anti-TIM-3 therapy counteracts circE7-associated immune resistance in models."	0.898
39378323	Anatolian journal of cardiology	2024	Hsa-circ-ACSL1 Enhances Apoptosis and Autophagy in Myocarditis Cardiomyocytes Through the miR-7-5p/XBP1 Axis.			mmu_circ_ACSL1	ACSL1	Viral myocarditis / VMC	MONDO:0023161	viral myocarditis	up-regulated	RT-qPCR	"In CVB3-induced viral myocarditis models, circ-ACSL1 is up-regulated and promotes myocardial inflammation, apoptosis, and autophagy. It functions as a ceRNA by sponging miR-7-5p to increase XBP1 expression, and genetic perturbation of miR-7-5p or XBP1 rescues the circ-ACSL1-driven phenotype."	0.7213
39378323	Anatolian journal of cardiology	2024	Hsa-circ-ACSL1 Enhances Apoptosis and Autophagy in Myocarditis Cardiomyocytes Through the miR-7-5p/XBP1 Axis.			has_circ_ACSL1	ACSL1	Viral myocarditis / VMC	MONDO:0023161	viral myocarditis	up-regulated	RT-qPCR	"In CVB3-induced viral myocarditis models, circ-ACSL1 is up-regulated and promotes myocardial inflammation, apoptosis, and autophagy. It functions as a ceRNA by sponging miR-7-5p to increase XBP1 expression, and genetic perturbation of miR-7-5p or XBP1 rescues the circ-ACSL1-driven phenotype."	0.7213
39379756	Discover oncology	2024	CircTSN promotes the proliferation and metastasis of gastric cancer through the miR-1825/SLC38A2 signaling axis.		circTSN	hsa_circ_TSN	TSN	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	circTSN is up-regulated in gastric cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes GC cell proliferation and migration/metastasis and enhances tumor growth in vivo by sponging miR-1825 to upregulate SLC38A2 (circTSN/miR-1825/SLC38A2 axis). High circTSN expression is associated with worse overall survival.	0.8571
39382613	Cell biology and toxicology	2024	EIF4A3-mediated oncogenic circRNA hsa_circ_0001165 advances esophageal squamous cell carcinoma progression through the miR-381-3p/TNS3 pathway.	hsa_circ_0001165	circ_0001165 / hsa_circ_001165	hsa_circ_NCOA3	NCOA3	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001165 is up-regulated in ESCC tissues and cell lines and promotes proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, EIF4A3 enhances hsa_circ_0001165 biogenesis, and hsa_circ_0001165 functions as a ceRNA by sponging miR-381-3p to increase TNS3 expression."	0.8771
39384750	Cell death discovery	2024	CircMETTL3-156aa reshapes the glycolytic metabolism of macrophages to promote M1 polarization and induce cytokine storms in sHLH.		circMETTL3 / cirMETTL3	hsa_circ_METTL3	METTL3	Secondary Hemophagocytic lymphohistiocytosis / sHLH	MONDO:0015542	secondary hemophagocytic lymphohistiocytosis	up-regulated	RT-qPCR; Microarray	"circMETTL3 is up-regulated in plasma exosomes of pediatric sHLH and has diagnostic potential. It promotes M1 macrophage polarization and cytokine storm by encoding METTL3-156aa, which binds LDHA to enhance macrophage glycolysis and lactate production; lactate upregulates SRSF10 via histone lactylation to increase circMETTL3 biogenesis, forming a positive feedback loop."	0.8905
39394197	Cell death & disease	2024	cNEK6 induces gemcitabine resistance by promoting glycolysis in pancreatic ductal adenocarcinoma via the SNRPA/PPA2c/mTORC1 axis.	hsa_circ_0008383	cNEK6 / circ-NEK6	hsa_circ_NEK6	NEK6	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"In PDAC, cNEK6 (hsa_circ_0008383) is up-regulated in gemcitabine-resistant tumors/cells and promotes glycolysis, leading to gemcitabine resistance. Mechanistically, cNEK6 binds and stabilizes SNRPA by blocking BTRC-mediated K48 ubiquitination, which suppresses PP2Ac translation via G-quadruplex binding and activates mTORC1 signaling. High cNEK6 in tumor tissue or peripheral blood associates with poor survival and may guide rapamycin-based sensitization to gemcitabine."	0.8823
39397316	Clinical and translational medicine	2024	Comprehensive circular RNA profiling provides insight into colorectal cancer pathogenesis and reveals diagnostically relevant biomarkers.	hsa_circ_0001461		hsa_circ_ABCE1	ABCE1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	unknown	RT-qPCR; RNA-seq	"In CRC models, hsa_circ_0001461 functions as an anti-proliferative circRNA: siRNA-mediated silencing in LoVo cells decreased proliferation. The study also places it within a predicted circRNA-miRNA-mRNA regulatory network and reports concordant expression with its host gene ABCE1."	0.6956
39397316	Clinical and translational medicine	2024	Comprehensive circular RNA profiling provides insight into colorectal cancer pathogenesis and reveals diagnostically relevant biomarkers.	hsa_circ_0087960	hsa_circ0087960	hsa_circ_FABP4	FABP4	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	unknown	RT-qPCR; RNA-seq	"In CRC cells, hsa_circ_0087960 supports proliferation: its silencing increased proliferation in LoVo cells, implying a pro-proliferative role for the endogenous circRNA. It is included in a predicted circRNA-miRNA-mRNA regulatory network and shows concordant expression with its host gene FABP4."	0.6956
39397316	Clinical and translational medicine	2024	Comprehensive circular RNA profiling provides insight into colorectal cancer pathogenesis and reveals diagnostically relevant biomarkers.	hsa_circ_0019223		hsa_circ_RNF103	RNF103	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	unknown	RT-qPCR; RNA-seq	"In CRC cells, hsa_circ_0019223 is functionally linked to proliferation: silencing increased LoVo cell proliferation, implying a pro-proliferative role for the endogenous circRNA. It is part of a predicted circRNA-miRNA-mRNA regulatory network and shows concordant expression with its host gene RNF103."	0.6956
39397316	Clinical and translational medicine	2024	Comprehensive circular RNA profiling provides insight into colorectal cancer pathogenesis and reveals diagnostically relevant biomarkers.	hsa_circ_0073244				colorectal cancer / CRC	MONDO:0005575	colorectal cancer	unknown	RT-qPCR; RNA-seq	"hsa_circ_0073244 was identified as a diagnostically relevant circRNA for CRC, showing outstanding discrimination between CRC and controls with AUC 0.9717 in the study's evaluation."	0.6556
39397316	Clinical and translational medicine	2024	Comprehensive circular RNA profiling provides insight into colorectal cancer pathogenesis and reveals diagnostically relevant biomarkers.	hsa_circ_0008039				colorectal cancer / CRC	MONDO:0005575	colorectal cancer	dysregulated	RNA-seq	"hsa_circ_0008039 shows stage-associated expression changes in CRC (early vs late stage), indicating potential utility as a CRC staging biomarker."	0.1768
39397316	Clinical and translational medicine	2024	Comprehensive circular RNA profiling provides insight into colorectal cancer pathogenesis and reveals diagnostically relevant biomarkers.	hsa_circ_0004865				colorectal cancer / CRC	MONDO:0005575	colorectal cancer	dysregulated	RNA-seq	"hsa_circ_0004865 shows significant expression differences between early- and late-stage CRC, supporting its potential as a staging biomarker."	0.1768
39397316	Clinical and translational medicine	2024	Comprehensive circular RNA profiling provides insight into colorectal cancer pathogenesis and reveals diagnostically relevant biomarkers.	hsa_circ_0077837				colorectal cancer / CRC	MONDO:0005575	colorectal cancer	dysregulated	RNA-seq	"hsa_circ_0077837 exhibits significant expression differences between early- and late-stage CRC, indicating potential as a CRC staging biomarker."	0.1768
39397316	Clinical and translational medicine	2024	Comprehensive circular RNA profiling provides insight into colorectal cancer pathogenesis and reveals diagnostically relevant biomarkers.	hsa_circ_0000110		hsa_circ_PTPN22	PTPN22	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	unknown	RNA-seq	"hsa_circ_0000110 (PTPN22) is highlighted via single-cell-based analysis as enriched in plasma B cells, suggesting potential utility as a non-invasive diagnostic biomarker for CRC, though the study does not report a specific up/down direction in bulk tumors."	0.1768
39398229	Journal of inflammation research	2024	Downregulation of Circular RNA Gla Reduced Astrocyte Inflammatory Status by Regulating miR-488/MEKK1 Levels and Promoted Functional Recovery After Spinal Cord Injury.		circGla	mmu_circ_Gla	Gla	spinal cord injury / SCI	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR; RNA-seq	"In a mouse SCI model, circGla is upregulated and mainly localized in astrocyte cytoplasm. circGla promotes astrocyte inflammation by sponging miR-488 to increase MEKK1 and activate MAPK (JNK/p38) signaling, while circGla knockdown reduces inflammatory cytokines and improves functional recovery."	0.8405
39399378	Non-coding RNA research	2025	Upregulation of circGDI2 inhibits tumorigenesis by stabilizing the expression of RNA m6A demethylase FTO in oral squamous cell carcinoma.		circGDI2	hsa_circ_GDI2	GDI2	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR	"circGDI2 is down-regulated in OSCC tissues and cell lines and acts as a tumour suppressor. It directly binds the FTO protein, stabilizes it against degradation, reduces cellular m6A methylation, and thereby inhibits OSCC cell proliferation, migration, invasion and xenograft tumorigenesis."	0.8682
39402211	Cell death and differentiation	2025	127aa encoded by circSpdyA promotes FA synthesis and NK cell repression in breast cancers.	hsa_circ_0053332	circSpdyA	hsa_circ_SpdyA	SpdyA	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; RNA-seq	"circSpdyA (hsa_circ_0053332) is up-regulated in TNBC tumors and is predominantly cytoplasmic. It encodes a 127-aa peptide that promotes fatty-acid metabolic reprogramming (de novo FA synthesis/FAO) via FASN interaction, thereby enhancing tumor growth and contributing to NK-cell infiltration/function repression in the tumor microenvironment."	0.775
39402642	Journal of translational medicine	2024	m6A-modified circXPO1 accelerates colorectal cancer progression via interaction with FMRP to promote WWC2 mRNA decay.	hsa_circ_0001017	circXPO1	hsa_circ_XPO1	XPO1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circXPO1 (hsa_circ_0001017), derived from XPO1, is up-regulated in colorectal cancer and predicts poor survival. It is mainly cytoplasmic and promotes CRC growth, EMT, invasion and metastasis by an m6A-dependent mechanism (ALKBH5/IGF2BP2) and by binding the RBP FMRP to destabilize WWC2 mRNA, thereby activating Hippo-YAP signaling."	0.8912
39404430	Cells	2024	Identification of hsa_circ_0018905 as a New Potential Biomarker for Multiple Sclerosis.	hsa_circ_0000518		hsa_circ_RPPH1	RPPH1	multiple sclerosis / MS	MONDO:0005301	multiple sclerosis	up-regulated	RT-qPCR; Microarray	hsa_circ_0000518 is up-regulated in PBMCs of MS (RRMS) patients versus healthy controls and was also detected as increased in serum. The study further predicts it participates in circRNA_miRNA_mRNA and circRNA_RBP regulatory networks relevant to MS-associated genes.	0.5135
39404430	Cells	2024	Identification of hsa_circ_0018905 as a New Potential Biomarker for Multiple Sclerosis.	hsa_circ_0000517		hsa_circ_RPPH1	RPPH1	multiple sclerosis / MS	MONDO:0005301	multiple sclerosis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000517 is up-regulated in PBMCs from MS patients and is predicted to act within a ceRNA network, potentially sponging miR-326 and affecting MS-associated gene regulation."	0.5135
39404430	Cells	2024	Identification of hsa_circ_0018905 as a New Potential Biomarker for Multiple Sclerosis.	hsa_circ_0000514		hsa_circ_RPPH1	RPPH1	multiple sclerosis / MS	MONDO:0005301	multiple sclerosis	up-regulated	RT-qPCR; Microarray	hsa_circ_0000514 is up-regulated in MS PBMCs and is also validated as detectable in serum from MS patients. The study suggests it may contribute to MS-related processes through RBP (HuR) sequestration.	0.5135
39404430	Cells	2024	Identification of hsa_circ_0018905 as a New Potential Biomarker for Multiple Sclerosis.	hsa_circ_0000511		hsa_circ_RPPH1	RPPH1	multiple sclerosis / MS	MONDO:0005301	multiple sclerosis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000511 is up-regulated in MS PBMCs versus controls and is also validated in serum. Its PBMC level is lower in more disabled RRMS/SPMS patients (higher EDSS), suggesting association with disease severity and involvement in regulatory networks including RREB1 and RBP sequestration (HuR)."	0.5135
39404430	Cells	2024	Identification of hsa_circ_0018905 as a New Potential Biomarker for Multiple Sclerosis.	hsa_circ_0018905		hsa_circ_SAMD8	SAMD8	multiple sclerosis / MS	MONDO:0005301	multiple sclerosis	down-regulated	RT-qPCR; Microarray	hsa_circ_0018905 is down-regulated in MS PBMCs and shows further reduction with greater disability and progressive MS forms. It has strong diagnostic potential by ROC analysis and is predicted to participate in a ceRNA axis involving miRNA-6727-3p and IKZF3.	0.5963
39404430	Cells	2024	Identification of hsa_circ_0018905 as a New Potential Biomarker for Multiple Sclerosis.	hsa_circ_0048764		hsa_circ_RPL36	RPL36	multiple sclerosis / MS	MONDO:0005301	multiple sclerosis	down-regulated	RT-qPCR; Microarray	"hsa_circ_0048764 is down-regulated in MS PBMCs and is predicted to function in a ceRNA axis by sponging miRNA-4270, thereby influencing MS-relevant targets including STAT3, ZFP36L1, VCAM1, and others."	0.5135
39404430	Cells	2024	Identification of hsa_circ_0018905 as a New Potential Biomarker for Multiple Sclerosis.	hsa_circ_0003445	hsa_circ_003445	hsa_circ_HDAC4	HDAC4	multiple sclerosis / MS	MONDO:0005301	multiple sclerosis	down-regulated	RT-qPCR; Microarray	"hsa_circ_0003445 is down-regulated in MS PBMCs versus controls and shows diagnostic value by ROC analysis. It is predicted to act in a ceRNA axis involving miRNA-612/miRNA-6727-3p and IKZF3, and may converge on PLEC regulation via miRNA-mediated interactions."	0.5963
39407304	Orphanet journal of rare diseases	2024	Identification of circRNA CDR1as/miR-214-3p regulatory axis in Legg-Calv¨¦-Perthes disease.			hsa_circ_CDR1	CDR1	Legg-Calv¨¦-Perthes disease / LCPD	MONDO:0007885	Legg-Calve-Perthes disease	up-regulated	RT-qPCR	circCDR1as is up-regulated in LCPD patient cartilage/serum/chondrocytes and negatively correlates with miR-214-3p. It promotes DEX-induced chondrocyte injury and suppresses M2 macrophage polarization and angiogenesis by recruiting PRC2 (EZH2/SUZ12/EED) to epigenetically repress miR-214-3p via H3K27me3.	0.7334
39412095	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2024	EIF4A3-Induced Circular RNA CircDdb1 Promotes Muscle Atrophy through Encoding a Novel Protein CircDdb1-867aa.	hsa_circ_0022284	circDdb1	hsa_circ_DDB1	DDB1	skeletal muscle atrophy	MONDO:0003939	muscle tissue disorder	up-regulated	RT-qPCR; RNA-seq	"circDdb1 is up-regulated across multiple muscle atrophy models and in aged human muscle. It promotes muscle atrophy largely by encoding the protein circDdb1-867aa, which binds eEF2 and increases eEF2 Thr56 phosphorylation to suppress translation; its biogenesis is promoted by the RBP EIF4A3, and circDdb1 inhibition attenuates atrophy in vitro and in vivo."	0.7991
39412095	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2024	EIF4A3-Induced Circular RNA CircDdb1 Promotes Muscle Atrophy through Encoding a Novel Protein CircDdb1-867aa.	Mmu_circ_0007604	circDdb1	mmu_circ_DDB1	DDB1	skeletal muscle atrophy	MONDO:0003939	muscle tissue disorder	up-regulated	RT-qPCR; RNA-seq	"circDdb1 is up-regulated across multiple muscle atrophy models and in aged human muscle. It promotes muscle atrophy largely by encoding the protein circDdb1-867aa, which binds eEF2 and increases eEF2 Thr56 phosphorylation to suppress translation; its biogenesis is promoted by the RBP EIF4A3, and circDdb1 inhibition attenuates atrophy in vitro and in vivo."	0.7991
39412408	The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology	2024	Circ_0008035 Promotes Gastric Cancer Development via the miR-429/SMAD2 Cascade.	hsa_circ_0008035	Circ_0008035	hsa_circ_EXT1	EXT1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_0008035 (from host gene EXT1) is up-regulated in gastric cancer tissues and cell lines and promotes malignant phenotypes (proliferation, cell-cycle progression, migration/invasion, angiogenesis) while inhibiting apoptosis. Mechanistically, it sponges miR-429 to increase SMAD2 expression, and circ_0008035 knockdown suppresses xenograft tumor growth."	0.7488
39414635	Cellular and molecular life sciences : CMLS	2024	N6-methyladenosine-modified circCDK14 promotes ossification of the ligamentum flavum via epigenetic modulation by targeting AFF4.	hsa_circ_0001721	circCDK14	hsa_circ_CDK14	CDK14	ossification of the ligamentum flavum / OLF	MONDO:0002081	musculoskeletal system disorder	up-regulated	RT-qPCR; Microarray	"circCDK14 is up-regulated in OLF tissues and promotes osteogenic differentiation of ligamentum flavum cells. It functions as a ceRNA by sponging miR-93-5p to increase AFF4, and its abundance is enhanced by WTAP-mediated m6A modification recognized by IGF2BP3 to improve circCDK14 stability."	0.869
39419900	Discover oncology	2024	Circ_0001047 inhibits prostate cancer progression and enhances abiraterone sensitivity via miR-122-5p/FKBP5/PHLPP1/AKT axis in vitro.	hsa_circ_0001047	circ_0001047	hsa_circ_NCAPH	NCAPH	prostate cancer / PCa	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR	"circ_0001047 is down-regulated in prostate cancer tissues and cell lines and functions as a tumor suppressor. It sponges miR-122-5p to increase FKBP5 (and FKBP5/PHLPP1 signaling), thereby inhibiting AKT phosphorylation and reducing malignant phenotypes, while enhancing abiraterone sensitivity."	0.7595
39420345	Cardiovascular diabetology	2024	Endothelial cells derived extracellular vesicles promote diabetic arterial calcification via circ_0008362/miR-1251-5p/Runx2 axial.	hsa_circ_0008362	circ_0008362 / hsa_circRNA_0008362	hsa_circ_FBXW4	FBXW4	diabetes mellitus / DM	MONDO:0005015	diabetes mellitus	up-regulated	RT-qPCR	hsa_circ_0008362 is enriched in endothelial cell-derived extracellular vesicles under high-glucose/diabetic conditions and is transferred to VSMCs to promote vascular/arterial calcification. It promotes calcification by sponging miR-1251-5p to increase Runx2 and also by directly binding Runx2 protein to enhance its stability. Circulating plasma EV hsa_circ_0008362 is elevated in DM patients and correlates with coronary/aortic calcification severity.	0.8499
39424659	Scientific reports	2024	Construction of an interactome network among circRNA-miRNA-mRNA reveals new biomarkers in hBMSCs osteogenic differentiation.	hsa_circ_0001600	hsa_circFKBP5_002	hsa_circ_FKBP5	FKBP5	osteogenic differentiation	MONDO:0002081	musculoskeletal system disorder	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001600 is upregulated during osteogenic induction of hBMSCs and promotes osteogenic differentiation, as its knockdown reduces ALP activity/mineralization and osteogenic markers. Mechanistically, it is proposed to sponge hsa-miR-542-3p (and other miRNAs) and may influence BMP7 and/or its host gene FKBP5."	0.5804
39424659	Scientific reports	2024	Construction of an interactome network among circRNA-miRNA-mRNA reveals new biomarkers in hBMSCs osteogenic differentiation.	hsa_circ_0005991	hsa_circAPBB2_013	hsa_circ_APBB2	APBB2	osteogenic differentiation	MONDO:0002081	musculoskeletal system disorder	up-regulated	RT-qPCR; Microarray	hsa_circ_0005991 is upregulated during osteogenic induction of hBMSCs and is predicted to bind hsa-miR-424-5p within the constructed ceRNA network. The study did not report downstream targets or functional phenotypes specifically attributable to hsa_circ_0005991.	0.2465
39424659	Scientific reports	2024	Construction of an interactome network among circRNA-miRNA-mRNA reveals new biomarkers in hBMSCs osteogenic differentiation.	hsa_circ_0002415				osteogenic differentiation	MONDO:0002081	musculoskeletal system disorder	up-regulated	RT-qPCR; Microarray	"hsa_circ_0002415 is upregulated in hBMSCs after 7 days of osteogenic induction (RT-qPCR validation), and was included in the constructed circRNA-miRNA-mRNA ceRNA network. No specific downstream mechanism or functional assays were reported for this circRNA."	0.2465
39424659	Scientific reports	2024	Construction of an interactome network among circRNA-miRNA-mRNA reveals new biomarkers in hBMSCs osteogenic differentiation.	hsa_circ_0063756				osteogenic differentiation	MONDO:0002081	musculoskeletal system disorder	up-regulated	RT-qPCR; Microarray	hsa_circ_0063756 is upregulated in hBMSCs after 7 days of osteogenic induction (RT-qPCR validation) and was included among key circRNAs from the constructed ceRNA network. No specific mechanism or functional assays were reported for this circRNA.	0.2465
39424659	Scientific reports	2024	Construction of an interactome network among circRNA-miRNA-mRNA reveals new biomarkers in hBMSCs osteogenic differentiation.	hsa_circ_0072678				osteogenic differentiation	MONDO:0002081	musculoskeletal system disorder	up-regulated	RT-qPCR; Microarray	hsa_circ_0072678 is upregulated in hBMSCs after 7 days of osteogenic induction (RT-qPCR validation) and was part of the ceRNA network constructed in this study. No specific functional experiments or downstream mechanisms were reported for this circRNA.	0.2465
39424659	Scientific reports	2024	Construction of an interactome network among circRNA-miRNA-mRNA reveals new biomarkers in hBMSCs osteogenic differentiation.	hsa_circ_0008621				osteogenic differentiation	MONDO:0002081	musculoskeletal system disorder	down-regulated	RT-qPCR; Microarray	hsa_circ_0008621 is downregulated in hBMSCs after 7 days of osteogenic induction (RT-qPCR validation) and appears in the study¡¯s ceRNA network list. No specific mechanism or functional experiments were reported for this circRNA in osteogenic differentiation.	0.2465
39427093	Communications biology	2024	Identification of brain region-specific landscape and functions of clustered circRNAs in Alzheimer's disease using circMeta2.		MAN2A1-11161-A5BS	hsa_circ_MAN2A1	MAN2A1	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RNA-seq	"In the MSBB BM10 cortex region, the circRNA cluster MAN2A1-11161-A5BS is up-regulated in AD. Its shared cluster sequence is predicted to contain miR-9-5p binding sites and is associated with repressed miR-9-5p activity and upregulation of miR-9-5p target genes involved in neuronal/synaptic functions."	0.1768
39427093	Communications biology	2024	Identification of brain region-specific landscape and functions of clustered circRNAs in Alzheimer's disease using circMeta2.		ARMC8-9535-A5BS	hsa_circ_ARMC8	ARMC8	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RNA-seq	"In AD BM10 cortex, the circRNA cluster ARMC8-9535-A5BS is up-regulated and is predicted (together with WDR17-10690-A3BS) to sponge miR-144-3p. This coordinated soaking is supported by increased expression of miR-144-3p target genes, consistent with repression of miR-144-3p activity."	0.1768
39427093	Communications biology	2024	Identification of brain region-specific landscape and functions of clustered circRNAs in Alzheimer's disease using circMeta2.		WDR17-10690-A3BS	hsa_circ_WDR17	WDR17	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RNA-seq	"In AD BM10 cortex, the circRNA cluster WDR17-10690-A3BS is up-regulated and is predicted to act with ARMC8-9535-A5BS to sponge miR-144-3p, thereby repressing miR-144-3p activity and contributing to increased expression of its target genes."	0.1768
39427093	Communications biology	2024	Identification of brain region-specific landscape and functions of clustered circRNAs in Alzheimer's disease using circMeta2.		ARHGAP26-11281-A5BS	hsa_circ_ARHGAP26	ARHGAP26	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RNA-seq	"In AD cortex regions, ARHGAP26-11281-A5BS is down-regulated and is predicted to sponge miR-140-5p under normal conditions. Its depletion in AD is associated with release of miR-140-5p and increased miR-140-5p activity, reflected by reduced expression of miR-140-5p target genes."	0.1768
39427093	Communications biology	2024	Identification of brain region-specific landscape and functions of clustered circRNAs in Alzheimer's disease using circMeta2.		ARHGAP26-10077-A5BS	hsa_circ_ARHGAP26	ARHGAP26	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RNA-seq	"ARHGAP26-10077-A5BS is down-regulated in AD (BM22) and is predicted to normally sponge miR-140-5p via its common sequence. Its downregulation is proposed to release miR-140-5p, increasing miR-140-5p activity in AD brain."	0.1768
39427093	Communications biology	2024	Identification of brain region-specific landscape and functions of clustered circRNAs in Alzheimer's disease using circMeta2.		ASAP1-12100-A5BS	hsa_circ_ASAP1	ASAP1	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RNA-seq	"ASAP1-12100-A5BS shows progressive depletion with increasing AD severity in BM36. It is predicted to bind miR-455-3p, and its downregulation is associated with enhanced miR-455-3p activity and downstream suppression of miR-455-3p target genes, suggesting a role in AD progression."	0.1768
39428382	Clinical and translational medicine	2024	CircRNome-wide characterisation reveals the promoting role of circAATF in anti-PD-L1 immunotherapy of gallbladder carcinoma.		circAATF	hsa_circ_AATF	AATF	gallbladder carcinoma / GBC	MONDO:0003220	gallbladder carcinoma	up-regulated	RT-qPCR; Northern Blot; RNA-seq	"circAATF is up-regulated in gallbladder carcinoma and promotes tumour growth. Mechanistically, it increases PD-L1 via AKT phosphorylation and functions as a miR-142-5p sponge to derepress AATF and PD-L1. High circAATF is associated with poor patient prognosis and with improved response to anti-PD-L1 therapy in humanised xenograft models."	0.8898
39428538	The clinical respiratory journal	2024	Identification of a Plasma Exosomal lncRNA- and circRNA-Based ceRNA Regulatory Network in Patients With Lung Adenocarcinoma.	hsa_circ_0033861		hsa_circ_ADAM6	ADAM6	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circ-0033861 (circADAM6) is significantly upregulated in plasma exosomes from LUAD patients versus healthy controls (microarray and RT-qPCR). The study suggests it may serve as a circulating, non-invasive diagnostic biomarker candidate for LUAD."	0.5135
39428538	The clinical respiratory journal	2024	Identification of a Plasma Exosomal lncRNA- and circRNA-Based ceRNA Regulatory Network in Patients With Lung Adenocarcinoma.	hsa_circ_0043273		hsa_circ_TADA2A	TADA2A	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	circ-0043273 (circTADA2A) is upregulated in LUAD patient plasma exosomes and was validated by RT-qPCR. It is proposed as a candidate non-invasive diagnostic biomarker; prior studies cited suggest it can function as a ceRNA by sponging several miRNAs.	0.5135
39428538	The clinical respiratory journal	2024	Identification of a Plasma Exosomal lncRNA- and circRNA-Based ceRNA Regulatory Network in Patients With Lung Adenocarcinoma.	hsa_circ_0011959				lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	circ-0011959 is upregulated in LUAD patient plasma exosomes versus healthy controls and was validated by RT-qPCR. The study proposes it as a potential circulating diagnostic biomarker for LUAD.	0.5135
39430741	Frontiers in immunology	2024	Circular RNA TAF4B targeting MFN2 accelerates cell growth in bladder cancer through p27 depression and AKT activation.	hsa_circ_0047322		hsa_circ_TAF4B	TAF4B	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"In bladder cancer cell models, circTAF4B is up-regulated and mainly localized in the cytoplasm. circTAF4B promotes proliferation/colony formation and migration, at least partly by physically binding MFN2, suppressing p27 and enhancing cyclin D1/D3 to accelerate cell-cycle progression, and activating AKT signaling; prior work also links it to the miR-1298-5p/TGFA axis."	0.6882
39431006	Theranostics	2024	Hypoxia-driven M2-polarized macrophages facilitate the epithelial-mesenchymal transition of glioblastoma via extracellular vesicles.	hsa_circ_0003137		hsa_circ_CTNNB1	CTNNB1	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; RNA-seq	"In glioblastoma, hypoxia-induced M2-like TAMs deliver extracellular-vesicle-enriched circ_0003137 to tumor cells, increasing its level. circ_0003137 promotes EMT, migration and invasion by binding PTBP1 and enhancing PLOD3 mRNA stability, and its knockdown suppresses tumor progression and improves survival in an intracranial xenograft model."	0.8432
39435612	Annals of medicine	2024	Construction of circRNA-miRNA-mRNA ceRNA regulatory network and screening of diagnostic targets for tuberculosis.	hsa_circ_0000566				tuberculosis / TB	MONDO:0018076	tuberculosis	down-regulated	RNA-seq	"hsa_circ_0000566 is down-regulated in pulmonary TB blood samples and is included in a core ceRNA network. It is predicted to competitively bind hsa-miR-607, thereby influencing IFNG-related immune regulation and suggesting diagnostic potential for TB."	0.1768
39435612	Annals of medicine	2024	Construction of circRNA-miRNA-mRNA ceRNA regulatory network and screening of diagnostic targets for tuberculosis.	hsa_circ_0001844				tuberculosis / TB	MONDO:0018076	tuberculosis	down-regulated	RNA-seq	"hsa_circ_0001844 is identified as a down-regulated core circRNA in pulmonary TB blood by transcriptome sequencing. It is predicted to sponge hsa-miR-607 within a ceRNA network to regulate IFNG, suggesting diagnostic potential."	0.1768
39435612	Annals of medicine	2024	Construction of circRNA-miRNA-mRNA ceRNA regulatory network and screening of diagnostic targets for tuberculosis.	hsa_circ_0005408				tuberculosis / TB	MONDO:0018076	tuberculosis	down-regulated	RNA-seq	"hsa_circ_0005408 is a down-regulated core circRNA in pulmonary TB blood samples. It is predicted to act as a ceRNA by binding hsa-miR-607 and thereby modulating IFNG within an immune-related regulatory network, and it is proposed as a diagnostic target for TB."	0.1768
39435612	Annals of medicine	2024	Construction of circRNA-miRNA-mRNA ceRNA regulatory network and screening of diagnostic targets for tuberculosis.	hsa_circ_0007587				tuberculosis / TB	MONDO:0018076	tuberculosis	down-regulated	RNA-seq	"hsa_circ_0007587 is part of a down-regulated core circRNA set in pulmonary TB blood. It is predicted to bind hsa-miR-607 in a ceRNA network and thereby relate to IFNG-associated immune regulation, and is suggested as a diagnostic target."	0.1768
39435612	Annals of medicine	2024	Construction of circRNA-miRNA-mRNA ceRNA regulatory network and screening of diagnostic targets for tuberculosis.	hsa_circ_0086710				tuberculosis / TB	MONDO:0018076	tuberculosis	down-regulated	RNA-seq	hsa_circ_0086710 is a down-regulated core circRNA identified in pulmonary TB whole blood by RNA-seq. It is predicted to participate in a ceRNA network by binding hsa-miR-607 to regulate IFNG and is proposed as a diagnostic target for TB.	0.1768
39439709	Archives of medical science : AMS	2024	Circ-VPS13C enhances cisplatin resistance in ovarian cancer via modulating the miR-106b-5p/YWHAZ axis.		hsa-circ-001567	hsa_circ_VPS13C	VPS13C	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circ-VPS13C is up-regulated in cisplatin-resistant ovarian cancer tissues/cells and promotes cisplatin resistance. Mechanistically, it sponges miR-106b-5p to increase YWHAZ expression, thereby enhancing autophagy and reducing cisplatin-induced apoptosis, with effects validated in a cell line-derived xenograft model."	0.7126
39440063	Journal of Cancer	2024	CircSP3 encodes SP3-461aa to promote ccRCC progression via stabilizing MYH9 and activating the PI3K-Akt signaling pathway.	hsa_circ_0002642	circSP3	hsa_circ_SP3	SP3	clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"circSP3 (hsa_circ_0002642) is up-regulated in ccRCC tissues and cell lines and promotes malignant phenotypes. It localizes mainly in the cytoplasm and can be translated via an IRES to produce SP3-461aa, which binds and stabilizes MYH9 by reducing ubiquitination, thereby activating PI3K/AKT signaling to enhance proliferation and metastasis."	0.872
39443113	Endocrine journal	2025	Inhibition of mmu_circ_0009303 improves metabolic dysfunction-associated steatotic liver disease by regulating lipid metabolism and oxidative stress.	mmu_circ_0009303	circ_0009303	mmu_circ_Trpm7	Trpm7	metabolic dysfunction-associated steatotic liver disease / MASLD	MONDO:0013209	metabolic dysfunction-associated steatotic liver disease	up-regulated	RT-qPCR	"mmu_circ_0009303 is up-regulated in MASLD cell and mouse models and is mainly localized in the cytoplasm. It promotes lipid deposition, oxidative stress, inflammation and apoptosis by sponging mmu-miR-182-5p to regulate Foxo3 and by affecting lipid metabolism-related proteins (e.g., CPT1A, SREBP1, FAS, PPARalpha/gamma)."	0.6745
39443946	Journal of nanobiotechnology	2024	m6A-modified exosome-derived circHIF1alpha binding to KH domain of IGF2BP3 mediates DNA damage and arrests G1/S transition phase to resists bacterial infection in bacteremia.		circHIF1alpha / circHIF1a	ssc_circ_HIF1alpha	HIF1alpha	bacteremia	MONDO:0005229	bacterial infectious disease with sepsis	down-regulated	RT-qPCR; RNA-seq	"Exosome-derived circHIF1alpha is down-regulated in exosomes from bacterially infected PIEC cells but can be transferred to recipient PK-15 cells, where it suppresses proliferation, promotes DNA damage, and induces G1/S arrest. Mechanistically, m6A-modified circHIF1alpha binds the KH domain of IGF2BP3, enhancing IGF2BP3 stability and linking to RCC2/gamma-H2AX-mediated DNA damage, thereby reducing bacterial adhesion/invasion and improving resistance to infection in vivo."	0.8292
39449799	Oncology research	2024	CircTIAM1 overexpression promotes the progression of papillary thyroid cancer by regulating the miR-338-3p/LASP1 axis.	hsa_circ_0061406	circTIAM1	hsa_circ_TIAM1	TIAM1	papillary thyroid cancer / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	circTIAM1 is up-regulated in papillary thyroid cancer tissues and cell lines and acts as an oncogenic circRNA. It mainly localizes in the cytoplasm and promotes proliferation/invasion and tumor growth by sponging miR-338-3p to upregulate LASP1.	0.8635
39451243	Cells	2024	"Circular RNA hsa_circ_0008726 Targets the hsa-miR-206-3p/KLF4 Axis to Modulate 4,4'-Methylene Diphenyl Diisocyanate-Glutathione Conjugate-Induced Chemokine Transcription in Macrophages."	hsa_circ_0008726		hsa_circ_DNAJB6	DNAJB6	occupational asthma	MONDO:0022742	occupational asthma	up-regulated	RT-qPCR	"In MDI-GSH_exposed THP-1 macrophages, hsa_circ_0008726 is induced and binds/sponges hsa-miR-206-3p via AGO/RISC, leading to reduced miR-206-3p and increased KLF4. This promotes KLF4-driven M2 macrophage-associated markers/chemokines (CD206, TGM2, CCL17, CCL22, CCL24) and enhances T-cell/eosinophil chemotaxis, suggesting a potential role in MDI-associated occupational asthma pathogenesis."	0.6575
39452097	Biology	2024	Whole-Transcriptome Analysis Reveals Potential CeRNA Regulatory Mechanism in Takifugu rubripes against Cryptocaryon irritans Infection.		circ_0000361			Cryptocaryon irritans infection	MONDO:0005135	parasitic infectious disease	up-regulated	RNA-seq	"circ_0000361 is differentially up-regulated in infected Takifugu rubripes gill tissue and is proposed to act in a ceRNA network. It potentially sponges fru-miR-204a (and competes with fru-miR-194), influencing the downstream immune-related target fzd3a during Cryptocaryon irritans infection."	0.3641
39457549	Biomedicines	2024	Comprehensive Bioinformatics Analysis Reveals the Potential Role of the hsa_circ_0001081/miR-26b-5p Axis in Regulating COL15A1 and TRIB3 within Hypoxia-Induced miRNA/mRNA Networks in Glioblastoma Cells.	hsa_circ_0001081	circ_0001081	hsa_circ_DCAF17	DCAF17	glioblastoma / GBM	MONDO:0018177	glioblastoma	down-regulated	Microarray	"This study proposes a putative ceRNA axis in glioblastoma in which hsa_circ_0001081 may regulate miR-26b-5p and thereby affect the mRNA targets COL15A1 and TRIB3. The authors suggest this axis could influence collagen-associated extracellular matrix processes under hypoxia, but emphasize that the findings require experimental validation."	0.1768
39463204	Acta biochimica et biophysica Sinica	2024	CircMALAT1 promotes the proliferation and metastasis of intrahepatic cholangiocarcinoma via the miR-512-5p/VCAM1 axis.		circMALAT1 / cMALAT1	hsa_circ_MALAT1	MALAT1	intrahepatic cholangiocarcinoma / ICC	MONDO:0003210	intrahepatic cholangiocarcinoma	up-regulated	RT-qPCR	"circMALAT1 (cMALAT1) is up-regulated in ICC context and acts as an oncogenic circRNA. It sponges miR-512-5p to relieve repression of VCAM1, thereby activating PI3K/AKT signaling and promoting ICC proliferation, EMT-associated migration/invasion, and tumor growth while inhibiting apoptosis."	0.7597
39465973	Thoracic cancer	2024	CircSEC24A induces KLF8 expression to promote the malignant progression of non-small cell lung cancer by regulating miR-1253.	hsa_circ_0003528	CircSEC24A / Circ_0003528	hsa_circ_SEC24A	SEC24A	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"CircSEC24A is up-regulated in NSCLC tissues and cell lines and functions as an oncogenic circRNA. It sponges miR-1253 to de-repress KLF8, thereby promoting proliferation and glycolysis while inhibiting apoptosis, and its knockdown suppresses xenograft tumor growth."	0.7975
39466086	Biomolecules & biomedicine	2025	Hsa_circ_0001492 regulates the hsa-miR-145-5p/ovarian carcinoma immunoreactive antigen domain 2 axis to promote the progression of lung adenocarcinoma.	hsa_circ_0001492		hsa_circ_ERBB2IP	ERBB2IP	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"hsa_circ_0001492 is up-regulated in LUAD tissues/cells and mainly localizes to the cytoplasm. It promotes LUAD proliferation, migration, invasion and sphere formation by sponging miR-145-5p to de-repress OCIAD2, and its silencing inhibits xenograft tumor growth."	0.8439
39466687	Journal of hypertension	2025	CircPCNXL2 promotes preeclampsia progression by suppressing trophoblast cell proliferation and invasion via miR-487a-3p/interferon regulatory factor 2 axis.	hsa_circ_0003314	circPCNXL2 / circPCNLX2	hsa_circ_PCNXL2	PCNXL2	preeclampsia / PE	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR; Microarray	"circPCNXL2 is up-regulated in preeclampsia placental tissues and suppresses trophoblast proliferation, migration, and invasion. Mechanistically, it localizes to the cytoplasm and functions as a sponge for miR-487a-3p, thereby increasing IRF2 expression to promote PE progression."	0.7884
39467260	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2025	CircFndc3b Mediates Exercise-Induced Neuroprotection by Mitigating Microglial/Macrophage Pyroptosis via the ENO1/KLF2 Axis in Stroke Mice.	mmu_circ_0001113	mmu_circ_0 001113 / circFndc3b	mmu_circ_Fndc3b	Fndc3b	ischemic stroke / IS	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR; RNA-seq	"In MCAO ischemic stroke mice, circFndc3b is reduced in the penumbral/peri-infarct cortex, while exercise restores/increases its expression in microglia/macrophages and improves neurological outcomes. circFndc3b binds the RBP ENO1 to enhance ENO1-mediated stabilization of Klf2 mRNA (and also FUS mRNA), thereby increasing Klf2 to suppress NLRP3 inflammasome-driven pyroptosis; the ENO1/FUS arm promotes circFndc3b cyclization, forming a positive feedback loop."	0.8065
39469202	"Experimental biology and medicine (Maywood, N.J.)"	2024	Exosomal circPTPRK promotes angiogenesis after radiofrequency ablation in hepatocellular carcinoma.		circPTPRK	hsa_circ_PTPRK	PTPRK	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circPTPRK is up-regulated in heat-stimulated HCC cell-derived exosomes and increases in HUVECs after exosome uptake. Exosomal circPTPRK promotes HUVEC proliferation, migration, and tube formation, at least partly by upregulating the downstream target PLA2G4E."	0.5979
39469816	Thoracic cancer	2024	Exosome-transported circ_0001955 as a potent driver of breast cancer by regulating the miR-708-5p/PGK1 axis.	hsa_circ_0001955	circ_0001955	hsa_circ_CSNK1G1	CSNK1G1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0001955 is up-regulated in breast cancer tissues/cells and is enriched in exosomes. It promotes proliferation and tumor growth, enhances paclitaxel resistance (higher IC50), and stimulates glycolysis by sponging miR-708-5p to upregulate PGK1."	0.8571
39473004	Arthritis research & therapy	2024	Circ-CAMTA1 regulated by Ca2+ influx inhibited pyruvate carboxylase activity and modulate T cell function in patients with systemic lupus erythematosus.		circ-CAMTA1 / circ-CAMTA	hsa_circ_CAMTA1	CAMTA1	systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	down-regulated	RT-qPCR; RNA-seq	"circ-CAMTA1 is down-regulated in SLE patient T cells and inversely associated with disease activity. Mechanistically, circ-CAMTA1 binds and inhibits pyruvate carboxylase, impacts glucose metabolism, and suppresses miR-181c-5p leading to increased IL-2 secretion, thereby modulating T cell function."	0.7204
39473004	Arthritis research & therapy	2024	Circ-CAMTA1 regulated by Ca2+ influx inhibited pyruvate carboxylase activity and modulate T cell function in patients with systemic lupus erythematosus.		circ-ASH1L	hsa_circ_ASH1L	ASH1L	systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	down-regulated	RT-qPCR; RNA-seq	circ-ASH1L is down-regulated in T cells from SLE patients and is further reduced in those with higher disease activity; no mechanistic or functional experiments were performed for circ-ASH1L in this study.	0.4773
39473004	Arthritis research & therapy	2024	Circ-CAMTA1 regulated by Ca2+ influx inhibited pyruvate carboxylase activity and modulate T cell function in patients with systemic lupus erythematosus.		circ-ASAP1	hsa_circ_ASAP1	ASAP1	systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	down-regulated	RT-qPCR; RNA-seq	circ-ASAP1 is down-regulated in T cells from SLE patients and is further reduced in those with higher disease activity; no mechanistic or functional experiments were performed for circ-ASAP1 in this study.	0.4773
39482783	Genome medicine	2024	Circular RNA landscape in extracellular vesicles from human biofluids.		circSMARCA5	hsa_circ_SMARCA5	SMARCA5	Systemic Disease Biomarkers	MONDO:0000001	disease	unknown	RT-qPCR; RNA-seq	"circSMARCA5 is highly prevalent and enriched in extracellular vesicles, showing higher EV abundance than its linear host gene. It can serve as a potential EV marker and is associated with RBP-mediated sorting through interaction with YBX1."	0.3401
39482783	Genome medicine	2024	Circular RNA landscape in extracellular vesicles from human biofluids.		circLTBP1	hsa_circ_LTBP1	latent transforming growth factor-beta binding protein-1	Systemic Disease Biomarkers	MONDO:0000001	disease	unknown	RNA-seq	"In plasma EVs, circLTBP1 is a prognosis-associated EV-circRNA: higher circLTBP1 expression corresponds to worse overall survival in multiple cancer types (BRCA, CRC, and SCLC)."	0.2995
39482783	Genome medicine	2024	Circular RNA landscape in extracellular vesicles from human biofluids.		circNFATC2	hsa_circ_NFATC2	NFATC2	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"In NSCLC patients receiving immunotherapy, EV-derived circNFATC2 is higher in responders and serves as a liquid-biopsy biomarker for response prediction, both as a single marker and in a Lasso model with circTBC1D22A."	0.5047
39482783	Genome medicine	2024	Circular RNA landscape in extracellular vesicles from human biofluids.		circTBC1D22A	hsa_circ_TBC1D22A	TBC1D22A	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"In NSCLC immunotherapy cohorts, EV-derived circTBC1D22A is higher in responders and serves as a liquid-biopsy biomarker for response prediction; it is also combined with circNFATC2 in a Lasso classifier with AUC ~0.81."	0.5047
39488792	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2024	Endosomal Trafficking Bypassed by the RAB5B-CD109 Interplay Promotes Axonogenesis in KRAS-Mutant Pancreatic Cancer.	hsa_circ_0007006	circPNIT	hsa_circ_DYM	DYM	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circPNIT (hsa_circ_0007006), a DYM-derived circRNA, is upregulated in KRASG12D PDAC tissues and serum EVs and correlates with PNI severity and poor survival. It scaffolds Rab5B and CD109 to promote lipid-raft/MVB-dependent loading into CD109+ EVs, which target neurons via TRPV1; in neurons, circPNIT enhances DSCAML1 transcription (with increased H3K9Ac), promotes axonogenesis, and activates the GFRalpha1/RET¡úMAPK/ERK signaling that facilitates PNI."	0.8993
39498085	Heliyon	2024	Hsa_circ_0004194 suppresses colorectal cancer progression via hsa-miR-27a-3p.	hsa_circ_0004194	Circ_0004194	hsa_circ_CTNNB1	CTNNB1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0004194 is down-regulated in colorectal cancer and acts as a tumor suppressor. It sponges hsa-miR-27a-3p to increase RXRalpha and suppress Wnt/beta-catenin signaling, thereby inhibiting CRC cell proliferation, migration/invasion and reducing tumor growth and liver metastasis in vivo."	0.8634
39501373	Cell communication and signaling : CCS	2024	Atomoxetine suppresses radioresistance in glioblastoma via circATIC/miR-520d-5p/Notch2-Hey1 axis.	hsa_circ_0058058	circATIC / circ0058058	hsa_circ_ATIC	ATIC	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR	"circATIC (hsa_circ_0058058), derived from ATIC, is upregulated in radioresistant glioblastoma cells and promotes malignant phenotypes by sponging miR-520d-5p, thereby enhancing the Notch2/Hey1 program. Atomoxetine reduces circATIC, restoring miR-520d-5p and suppressing radioresistance-associated tumorigenicity; circATIC is also detectable in plasma and is elevated after radiotherapy in patient samples."	0.6278
39502735	Annals of gastroenterological surgery	2024	Circ_0084615 promotes epithelial-mesenchymal transition-mediated tumor progression in hepatocellular carcinoma.	hsa_circ_0084615	circ_0084615			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0084615 is up-regulated in HCC and promotes proliferation, migration, invasion and EMT, as well as xenograft tumor growth. It functions mainly in the cytoplasm as a miRNA sponge for miR-1200, relieving repression of ACTL6A and increasing ACTL6A expression."	0.8037
39507257	iScience	2024	CircZNF609/miR-324-5p/voltage-dependent anion channel 1 axis promotes malignant progression of ovarian cancer cells.	hsa_circ_0000615	circZNF609	hsa_circ_ZNF609	ZNF609	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"CircZNF609 is up-regulated in ovarian cancer tissues and cell lines and is associated with lymph node metastasis, advanced stage, and poorer survival. Functionally, circZNF609 promotes proliferation, migration, invasion, EMT, and xenograft tumor growth by sponging miR-324-5p to upregulate VDAC1."	0.7365
39507963	Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition	2024	[Expression of circRNA_051778 in Lung Adenocarcinoma-Associated Malignant and Tuberculous Pleural Effusions and Its Clinical Significance].		circRNA_051778 / circRNA _051778	hsa_circ_BCAT2	BCAT2	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; Microarray	"This study reports that exosomal circRNA_051778 is significantly down-regulated in lung adenocarcinoma-associated malignant pleural effusion compared with tuberculous pleural effusion. A predicted circRNA_miRNA_mRNA network (five candidate miRNAs and 2852 intersecting mRNA targets) and GO/KEGG enrichment suggest possible involvement in signal transduction and cancer-related pathways. circRNA_051778 shows diagnostic value for distinguishing LA-MPE from TPE, especially combined with TCT, ESR, and TBA."	0.6709
39511561	Cancer cell international	2024	FUS/circZEB1/miR-128-3p/LBH feedback loop contributes to the malignant phenotype of GSCs via TNF-alpha-mediated NF-kappaB signaling pathway.	hsa_circ_0000230	circZEB1 / circZBE1	hsa_circ_ZEB1	ZEB1	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; Microarray	"circZEB1 is up-regulated in GBM and GSCs and promotes proliferation, invasion, stemness, and in vivo tumorigenesis. It functions as a miR-128-3p sponge to increase LBH, which enhances TNF-alpha and activates NF-kappaB signaling; LBH also increases FUS, and FUS binds circZEB1 to stabilize it, forming a positive feedback loop."	0.8871
39511617	BMC medical genomics	2024	Co-regulated ceRNA network mediated by circRNA and lncRNA in patients with gouty arthritis.		novel_circ_0030384 / novel_ circ_ 0030384	hsa_circ_TDRD3	TDRD3	gouty arthritis	MONDO:0005393	gout	down-regulated	RNA-seq	"novel_circ_0030384 is a downregulated upstream circRNA in a co-regulated ceRNA network in gouty arthritis. Its reduced abundance is proposed to weaken miRNA sponging (miR-550a-5p/miR-550a-3-5p), thereby enhancing repression of inflammatory-related mRNA targets such as GRK2, PSME1, FERMT3 and OS9 and contributing to inflammation via chemokine-associated processes."	0.2414
39520607	Discover oncology	2024	Hsa_circ_0000423 promotes colorectal cancer EMT and immune escape by competitive adsorption of miR-369-3p mediating CCND1 expression.	hsa_circ_0000423	circPPP1R12A / circ_0000423	hsa_circ_PPP1R12A	PPP1R12A	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"In colorectal cancer, hsa_circ_0000423 is up-regulated and promotes proliferation, migration/invasion, EMT, and immune escape while suppressing apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-369-3p to increase CCND1 expression, and its knockdown reduces PD-L1 and enhances T-cell-mediated anti-tumor responses in co-culture."	0.8122
39520719	"Cancer communications (London, England)"	2025	Discovery of a novel viroid-like circular RNA in colorectal cancer.		CCAV			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"This study discovered a novel viroid-like circular RNA, CCAV, in colorectal cancer and validated that CCAV is significantly up-regulated in tumor tissues versus adjacent tissues in a 100-patient cohort. Overexpression of CCAV in SW480 cells followed by transcriptome sequencing suggested downstream transcriptomic changes enriched in viral infection, immune-related diseases, and tumor-associated categories, but a specific mechanism was not established."	0.6362
39524791	Heliyon	2024	hsa_circ_0007755 competitively adsorbs miR-27b-3p to mediate CXCL2 expression and recruit Th1 cells to promote hypertrophic scars development.	hsa_circ_0007755				hypertrophic scar / HS	MONDO:0005348	keloid	up-regulated	RT-qPCR	"hsa_circ_0007755 is up-regulated in hypertrophic scars and promotes fibroblast proliferation, invasion, fibrosis and inflammatory signaling while inhibiting apoptosis. Mechanistically, it sponges miR-27b-3p to de-repress CXCL2, thereby modulating Th1/Th2 balance and contributing to HS progression."	0.7797
39524808	Heliyon	2024	Downregulation of circSTX6 suppresses tumor progression while facilitating radiosensitivity in cervical squamous cell carcinoma.	hsa_circ_0007905	circSTX6	hsa_circ_STX6		cervical squamous cell carcinoma / CSCC	MONDO:0006143	cervical squamous cell carcinoma	up-regulated	RT-qPCR	"circSTX6 is up-regulated in CSCC tissues, especially in radioresistant tumors. circSTX6 promotes proliferation and invasion and reduces radiosensitivity by regulating the miR-203a-3p/RAB27B ceRNA axis, and high circSTX6 expression predicts worse survival after radiotherapy."	0.7078
39526436	European journal of histochemistry : EJH	2024	Activation of Hedgehog pathway by circEEF2/miR-625-5p/TRPM2 axis promotes prostate cancer cell proliferation through mitochondrial stress.	hsa_circ_0048559	circEEF2	hsa_circ_EEF2	EEF2	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circEEF2 is upregulated in prostate cancer and acts as an oncogenic circRNA. It sponges miR-625-5p to relieve repression of TRPM2, thereby activating Hedgehog signaling (GLI1/GLI2) and enhancing mitochondrial stress, promoting malignant phenotypes and xenograft growth."	0.7346
39527152	Discover oncology	2024	Circ_0001741 exerts as a tumor promoter in ovarian cancer through the regulation of miR-491-5p/PRSS8 axis.	hsa_circ_0001741	Circ_0001741	hsa_circ_TNPO3	TNPO3	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circ_0001741 is up-regulated in ovarian cancer and mainly localizes to the cytoplasm. It promotes proliferation and metastasis-related behaviors and inhibits apoptosis by sponging miR-491-5p, thereby upregulating PRSS8, and its knockdown suppresses xenograft tumor growth."	0.7635
39529134	Genome medicine	2024	Identification of pathological pathways centered on circRNA dysregulation in association with irreversible progression of Alzheimer's disease.	hsa_circ_0003341	circGigyf2	hsa_circ_GIGYF2	Gigyf2 / GIGYF2	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR; RNA-seq	"circGigyf2/circGIGYF2 is progressively down-regulated at the irreversible progression stage of AD in 5xFAD mouse cortex and in specific human AD subcortical regions, correlating with dementia severity. Its reduction releases sponged miR-17-5p/miR-93-5p and CPSF6, enhancing miRNA silencing and CPSF6-mediated proximal polyadenylation, which promotes vulnerability to neuronal apoptosis."	0.717
39529134	Genome medicine	2024	Identification of pathological pathways centered on circRNA dysregulation in association with irreversible progression of Alzheimer's disease.		circGigyf2	mmu_circ_Gigyf2	Gigyf2 / GIGYF2	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR; RNA-seq	"circGigyf2/circGIGYF2 is progressively down-regulated at the irreversible progression stage of AD in 5xFAD mouse cortex and in specific human AD subcortical regions, correlating with dementia severity. Its reduction releases sponged miR-17-5p/miR-93-5p and CPSF6, enhancing miRNA silencing and CPSF6-mediated proximal polyadenylation, which promotes vulnerability to neuronal apoptosis."	0.717
39529543	Annals of medicine	2024	Hsa_circRNA_000166 accelerates breast cancer progression via the regulation of the miR-326/ELK1 and miR-330-5p/ELK1 axes.	hsa_circ_0000512	hsa_circRNA_000166 / circRPPH1	hsa_circ_RPPH1	RPPH1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circRNA_000166 (circRPPH1) is up-regulated in breast cancer tissues and cell lines and acts as an oncogenic circRNA. It sponges miR-326 and miR-330-5p, thereby relieving repression of ELK1 and promoting proliferation/migration while inhibiting apoptosis; high expression is associated with worse postoperative survival (PFS/OS)."	0.8423
39531509	Cancer research	2025	The circRNA cEMSY Induces Immunogenic Cell Death and Boosts Immunotherapy Efficacy in Lung Adenocarcinoma.		"cEMSY / circEmsy (10, 11, 12, 13, 14)"	hsa_circ_EMSY	EMSY	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; ISH; RNA-seq	"cEMSY is down-regulated in lung adenocarcinoma tissues and cells and functions as an immunogenic ICD inducer. It binds TDP-43 (RRM1-dependent) to promote mitochondrial TDP-43 aggregation, mtDNA leakage, and cGAS_STING activation, thereby enhancing antitumor immunity and sensitizing tumors to anti_PD-1 therapy, with favorable clinical immunotherapy response associations."	0.8792
39531509	Cancer research	2025	The circRNA cEMSY Induces Immunogenic Cell Death and Boosts Immunotherapy Efficacy in Lung Adenocarcinoma.		"cEMSY / circEmsy (10, 11, 12, 13, 14)"	mmu_circ_Emsy	Emsy	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; ISH; RNA-seq	"cEMSY is down-regulated in lung adenocarcinoma tissues and cells and functions as an immunogenic ICD inducer. It binds TDP-43 (RRM1-dependent) to promote mitochondrial TDP-43 aggregation, mtDNA leakage, and cGAS_STING activation, thereby enhancing antitumor immunity and sensitizing tumors to anti_PD-1 therapy, with favorable clinical immunotherapy response associations."	0.8792
39533214	Cellular & molecular biology letters	2024	m6A-modified circCacna1c regulates necroptosis and ischemic myocardial injury by inhibiting Hnrnpf entry into the nucleus.	mmu_circ_0001511	circCacna1c	mmu_circ_Cacna1c	Cacna1c	myocardial infarction / MI	MONDO:0005068	myocardial infarction	down-regulated	RT-qPCR	"circCacna1c is down-regulated during oxidative stress and in MI mouse hearts and acts as a protective factor by inhibiting cardiomyocyte necroptosis. It binds Hnrnpf in the cytoplasm to block Hnrnpf nuclear translocation and suppress RIPK1 expression, while its m6A-dependent stability is regulated by the FTO_YTHDF2 pathway."	0.8015
39534060	Journal of inflammation research	2024	Characterization of Immune-Related circRNAs and mRNAs in Human Chronic Atrophic Gastritis.		chrM:13298_13449+			chronic atrophic gastritis / CAG	MONDO:0006665	chronic atrophic gastritis	up-regulated	RT-qPCR; RNA-seq	"This novel circRNA (chrM:13298_13449+) is up-regulated in CAG gastric tissues and was among five circRNAs selected for an immune-related circRNA_mRNA co-expression network. Its expression change was supported by RNA-seq and validated by RT-qPCR, suggesting a potential link to immune dysregulation in CAG."	0.4032
39534060	Journal of inflammation research	2024	Characterization of Immune-Related circRNAs and mRNAs in Human Chronic Atrophic Gastritis.	hsa_circ_0005320				chronic atrophic gastritis / CAG	MONDO:0006665	chronic atrophic gastritis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005320 is up-regulated in CAG gastric tissues and was selected as one of five circRNAs strongly correlated with immune-related hub mRNAs in a circRNA_mRNA co-expression network. Its differential expression was detected by RNA-seq and validated by RT-qPCR, supporting its potential relevance to immune-related CAG pathogenesis."	0.4032
39534060	Journal of inflammation research	2024	Characterization of Immune-Related circRNAs and mRNAs in Human Chronic Atrophic Gastritis.	hsa_circ_0000339				chronic atrophic gastritis / CAG	MONDO:0006665	chronic atrophic gastritis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000339 is up-regulated in CAG gastric tissues and was included among five circRNAs used to build an immune-related circRNA_mRNA co-expression network. Its expression difference was identified by RNA-seq and validated by RT-qPCR, implying a possible role in CAG-associated immune alterations."	0.4032
39534060	Journal of inflammation research	2024	Characterization of Immune-Related circRNAs and mRNAs in Human Chronic Atrophic Gastritis.		chr7:100678797_100678973+			chronic atrophic gastritis / CAG	MONDO:0006665	chronic atrophic gastritis	up-regulated	RT-qPCR; RNA-seq	This novel circRNA defined by genomic coordinates (chr7:100678797_100678973+) is up-regulated in CAG gastric tissues and was selected as part of a circRNA_mRNA immune-related co-expression network. Its increased expression was detected by RNA-seq and validated by RT-qPCR.	0.4032
39534060	Journal of inflammation research	2024	Characterization of Immune-Related circRNAs and mRNAs in Human Chronic Atrophic Gastritis.	hsa_circ_0003664				chronic atrophic gastritis / CAG	MONDO:0006665	chronic atrophic gastritis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0003664 is up-regulated in CAG gastric tissues and was selected for constructing an immune-related circRNA_mRNA co-expression network. Its up-regulation was detected by RNA-seq and confirmed by RT-qPCR, indicating potential relevance as a CAG biomarker candidate."	0.4032
39538012	Communications biology	2024	Exosome-derived circ-001422 promotes tumor-associated macrophage M2 polarization to accelerate the progression of glioma.		circ-001422	hsa_circ_WHSC1	WHSC1	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; ISH; RNA-seq	"circ-001422 is up-regulated in glioma tissues/cells and predicts poor overall survival. Glioma cells package circ-001422 into exosomes and transfer it to macrophages, where it binds p300 and STAT3 to increase STAT3 acetylation and activate STAT3/NF-kappaB signaling, promoting M2 polarization and enhancing glioma proliferation and invasion/metastasis."	0.834
39538329	BMC biotechnology	2024	Analysis of hsa_circ_0136256 as a biomarker for fibrosis in systemic sclerosis.	mmu_circ_0005372		mmu_circ_Fzd3	Fzd3	systemic sclerosis / SSc	MONDO:0005100	systemic sclerosis	down-regulated	RT-qPCR; RNA-seq	"mmu_circ_0005372 (from Fzd3) is down-regulated in SSc mouse skin. It binds 4E-BP1, and restoring its expression alleviates skin fibrosis, likely by suppressing the 4E-BP1/mTOR axis."	0.6154
39538329	BMC biotechnology	2024	Analysis of hsa_circ_0136256 as a biomarker for fibrosis in systemic sclerosis.	hsa_circ_0136256		hsa_circ_FZD3	FZD3	systemic sclerosis / SSc	MONDO:0005100	systemic sclerosis	down-regulated	RT-qPCR	hsa_circ_0136256 (from FZD3) is down-regulated in PBMCs from SSc patients. It shows diagnostic potential (ROC AUC 0.719) and correlates with fibrosis-related clinical indices; interaction with 4E-BP1 is predicted but not experimentally validated in human samples here.	0.459
39542245	The Journal of biological chemistry	2024	The circular RNA circNFIX regulates MEF2C expression in muscle satellite cells in spastic cerebral palsy.	hsa_circ_0005660	circNFIX	hsa_circ_NFIX	NFIX	cerebral palsy / CP	MONDO:0006497	cerebral palsy	down-regulated	RT-qPCR	"In spastic cerebral palsy, circNFIX is down-regulated in muscle satellite cell-derived myoblasts/myotubes and skeletal muscle tissue, and shows increased nuclear localization. circNFIX functions as a ceRNA that sponges miR-373-3p to relieve translational repression of MEF2C, supporting MEF2C protein and sarcomere gene expression; circNFIX knockdown phenocopies CP by reducing MEF2C and myogenic fusion capacity."	0.7656
39543614	Journal of translational medicine	2024	N6-methyladenosine modification of circular RNA circASH2L suppresses growth and metastasis in hepatocellular carcinoma through regulating hsa-miR-525-3p/MTUS2 axis.	hsa_circ_0006302	circASH2L / hsa_circRNA_0006302	hsa_circ_ASH2L	ASH2L	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; ISH; Microarray	"circASH2L is down-regulated in hepatocellular carcinoma and functions as a tumor suppressor by inhibiting proliferation, migration/invasion, tumorigenesis and metastasis. It acts as a ceRNA that sponges miR-525-3p to de-repress MTUS2, and its expression is negatively regulated by METTL3-mediated m6A methylation that promotes circASH2L degradation."	0.904
39543767	Cell & bioscience	2024	"Ancestral retrovirus envelope protein ERVWE1 upregulates circ_0001810, a potential biomarker for schizophrenia, and induces neuronal mitochondrial dysfunction via activating AK2."	hsa_circ_0001810	circ_0001810	hsa_circ_NCOA2	NCOA2	schizophrenia	MONDO:0005090	schizophrenia	up-regulated	RT-qPCR	"hsa_circ_0001810 (circ_0001810), derived from NCOA2, is up-regulated in peripheral blood of schizophrenia patients and positively correlates with ERVWE1. It predominantly localizes in the cytoplasm and functions as a ceRNA by sponging miR-1197 to de-repress AK2, thereby contributing to neuronal mitochondrial dysfunction (ATP loss, mitochondrial depolarization, and disturbed mitochondrial dynamics/fragmentation)."	0.7749
39544243	Journal of clinical and translational hepatology	2024	Identification and Validation of the Hsa_circ_0001726/miR-140-3p/KRAS Axis in Hepatocellular Carcinoma Based on Microarray Analyses and Experiments.	hsa_circ_0001726				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"hsa_circ_0001726 is up-regulated in HCC tissues and cells and promotes HCC proliferation and migration. It functions through a ceRNA axis involving miR-140-3p and KRAS, and contributes to lenvatinib resistance. High hsa_circ_0001726 expression is associated with worse overall survival in HCC patients."	0.7752
39554543	Neuropsychiatric disease and treatment	2024	Correlation Between Family Dysfunction and Nonsuicidal Self-Injury in a Sample of Chinese Adolescents: The Mediating Effect of Alexithymia and circRNA_103636.		circRNA_103636 / hsa_circRNA_103636			nonsuicidal self-injury / NSSI	MONDO:0002025	psychiatric disorder	down-regulated	RT-qPCR	circRNA_103636 is lower expressed in PBMCs of adolescents with NSSI versus healthy controls (inferred from higher deltaCt). Its expression correlates with NSSI behavior/function scores and partially mediates the association between family dysfunction and NSSI in this clinical adolescent cohort.	0.459
39556281	Discover oncology	2024	Circ_0124346 facilitates cell proliferation of pancreatic adenocarcinoma cells by regulating lipid metabolism via miR-223-3p/ACSL3 axis.	hsa_circ_0124346	circ_0124346	hsa_circ_FAM116A	FAM116A	pancreatic adenocarcinoma / PAAD	MONDO:0006047	pancreatic adenocarcinoma	up-regulated	RT-qPCR	"circ_0124346 is up-regulated in PAAD tissues and cell lines and is associated with larger tumor size. It promotes PAAD cell proliferation and lipid synthesis by sponging miR-223-3p, thereby increasing ACSL3 expression (circ_0124346/miR-223-3p/ACSL3 axis)."	0.7684
39557914	NPJ Parkinson's disease	2024	Circulating blood circular RNA in Parkinson's Disease; from involvement in pathology to diagnostic tools in at-risk individuals.		CircRHBDD1	hsa_circ_RHBDD1	RHBDD1	Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	down-regulated	RNA-seq	CircRHBDD1 is reported as down-regulated in blood from Parkinson¡¯s disease cases compared with controls based on re-analysis of public blood RNA-seq datasets.	0.1768
39557914	NPJ Parkinson's disease	2024	Circulating blood circular RNA in Parkinson's Disease; from involvement in pathology to diagnostic tools in at-risk individuals.		circCSE1L	hsa_circ_CSE1L	CSE1L	Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	dysregulated	RNA-seq	circCSE1L is reported as dysregulated in blood from Parkinson¡¯s disease cases compared with controls in this large-scale re-analysis of public blood RNA-seq datasets.	0.1768
39557914	NPJ Parkinson's disease	2024	Circulating blood circular RNA in Parkinson's Disease; from involvement in pathology to diagnostic tools in at-risk individuals.		circRNF13	hsa_circ_RNF13	RNF13	Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	dysregulated	RNA-seq	circRNF13 is reported as dysregulated in blood from Parkinson¡¯s disease cases compared with controls in this study¡¯s cross-sectional meta-analysis of public blood RNA-seq cohorts.	0.1768
39557914	NPJ Parkinson's disease	2024	Circulating blood circular RNA in Parkinson's Disease; from involvement in pathology to diagnostic tools in at-risk individuals.		circSHOC2	hsa_circ_SHOC2	SHOC2	Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	dysregulated	RNA-seq	circSHOC2 is identified as a Parkinson¡¯s disease-associated dysregulated blood circRNA in the study¡¯s meta-analysis of PDBP and PPMI RNA-seq data.	0.1768
39557914	NPJ Parkinson's disease	2024	Circulating blood circular RNA in Parkinson's Disease; from involvement in pathology to diagnostic tools in at-risk individuals.		circAFF2	hsa_circ_AFF2	AFF2	Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	up-regulated	RNA-seq	circAFF2 is up-regulated in PD blood versus controls and is among the strongest candidate circRNAs across cohorts. It is also correlated with symptom severity (UPDRS-III) and shows potential clinical utility as part of circRNA biomarker panels.	0.348
39557914	NPJ Parkinson's disease	2024	Circulating blood circular RNA in Parkinson's Disease; from involvement in pathology to diagnostic tools in at-risk individuals.		circCCDC91	hsa_circ_CCDC91	CCDC91	Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	down-regulated	RNA-seq	"circCCDC91 is down-regulated in PD blood versus controls, but its association is influenced by blood cell composition and also appears affected by medication status in sensitivity analyses."	0.348
39557914	NPJ Parkinson's disease	2024	Circulating blood circular RNA in Parkinson's Disease; from involvement in pathology to diagnostic tools in at-risk individuals.		circETFA	hsa_circ_ETFA	ETFA	Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	down-regulated	RNA-seq	"circETFA is down-regulated in PD blood versus controls and shows evidence of association primarily in idiopathic PD rather than mutation carriers, within the study¡¯s sensitivity analyses."	0.348
39557914	NPJ Parkinson's disease	2024	Circulating blood circular RNA in Parkinson's Disease; from involvement in pathology to diagnostic tools in at-risk individuals.		circFAM13B	hsa_circ_FAM13B	FAM13B	Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	down-regulated	RNA-seq	circFAM13B is down-regulated in PD blood and is discussed as a potentially important contributor to PD pathogenesis. The study also notes that both linear and circular forms of FAM13B show independent associations with PD in blood.	0.348
39557914	NPJ Parkinson's disease	2024	Circulating blood circular RNA in Parkinson's Disease; from involvement in pathology to diagnostic tools in at-risk individuals.		circITGAX	hsa_circ_ITGAX	ITGAX	Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	up-regulated	RNA-seq	"circITGAX is up-regulated in PD blood and is associated with medication status; it correlates with motor symptom severity (UPDRS-III) and shows PD-associated longitudinal trajectory differences, supporting biomarker potential for monitoring."	0.348
39557914	NPJ Parkinson's disease	2024	Circulating blood circular RNA in Parkinson's Disease; from involvement in pathology to diagnostic tools in at-risk individuals.		circNCF1	hsa_circ_NCF1	NCF1	Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	up-regulated	RNA-seq	circNCF1 is up-regulated in PD blood and correlates with motor symptom severity (UPDRS-III). It is included among high-confidence PD-associated circRNAs used for biological contextualization via predicted miRNA targets and pathway enrichment.	0.348
39557914	NPJ Parkinson's disease	2024	Circulating blood circular RNA in Parkinson's Disease; from involvement in pathology to diagnostic tools in at-risk individuals.		circPADI4	hsa_circ_PADI4	PADI4	Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	up-regulated	RNA-seq	"circPADI4 is up-regulated in PD blood and correlates with motor symptom severity (UPDRS-III). Unlike other high-confidence circRNAs in the paper, it has no predicted miRNA targets reported by CircInteractome in this study."	0.348
39557914	NPJ Parkinson's disease	2024	Circulating blood circular RNA in Parkinson's Disease; from involvement in pathology to diagnostic tools in at-risk individuals.		circSPI1	hsa_circ_SPI1	SPI1	Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	up-regulated	RNA-seq	"circSPI1 is up-regulated in PD blood and correlates with motor symptom severity. The study highlights it as PD-associated independent of medication and cell-count confounding, and it is included in the high-confidence circRNA set used for biomarker modeling and functional miRNA-based annotation."	0.348
39557914	NPJ Parkinson's disease	2024	Circulating blood circular RNA in Parkinson's Disease; from involvement in pathology to diagnostic tools in at-risk individuals.		circSUZ12	hsa_circ_SUZ12	SUZ12	Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	down-regulated	RNA-seq	"circSUZ12 is down-regulated in PD blood and is highlighted as associated with genetic background, particularly in LRRK2 mutation carriers compared with SNCA carriers. It is included among high-confidence circRNAs used for miRNA-based functional enrichment and for diagnostic modeling in PD/at-risk participants."	0.348
39567496	Cell death & disease	2024	Androgen-targeted hsa_circ_0085121 encodes a novel protein and improves the development of prostate cancer through facilitating the activity of PI3K/Akt/mTOR pathway and enhancing AR-V7 alternative splicing.	hsa_circ_0085121	circRNF19A	hsa_circ_RNF19A	RNF19A	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0085121 (circRNF19A), derived from RNF19A, is up-regulated in prostate cancer tissues and cell lines and correlates with aggressive clinicopathological features. It encodes a 490-aa protein that promotes malignant phenotypes and drug resistance by interacting with HSP90AA1 to enhance AR nuclear activity and activate Akt/mTOR and PLK1 signaling, and by interacting with HNRNPF to facilitate AR-V7 alternative splicing and CRPC-related phenotypes."	0.8949
39572284	International dental journal	2025	Circ_0003072 Mediates the Pro-osteogenic Differentiation Effect of Betulinic Acid on Human Periodontal Ligament Stem Cells.	hsa_circ_0003072	circ_0003072			periodontitis	MONDO:0005076	periodontitis	up-regulated	RT-qPCR	"circ_0003072 is upregulated after BetA treatment in hPDLSCs and is required for BetA-enhanced osteogenic differentiation. Mechanistically, circ_0003072 sponges miR-488-3p to relieve repression of CHRDL1, thereby promoting osteogenic markers, ALP activity, and mineralization."	0.5495
39572643	Scientific reports	2024	Circular RNA HIPK3 mediates epithelial-mesenchymal transition of retinal pigment epithelial cells by sponging multiple microRNAs.		circRNA HIPK3 / circHIPK3	mmu_circ_HIPK3	HIPK3	epithelial-mesenchymal transition of retinal pigment epithelial cells	MONDO:0005283	retinal disorder	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in a TGF-beta1-induced RPE-EMT in vitro model and promotes EMT and cell migration. It functions mainly in the cytoplasm by sponging multiple miRNAs (notably including miR-106b-5p), supporting a ceRNA-like mechanism to modulate RPE-EMT."	0.6528
39578712	CNS neuroscience & therapeutics	2024	Interaction Between DHCR24 and hsa_circ_0015335 Facilitates Cognitive Impairment in Cerebral Small Vessel Disease Patients.	hsa_circ_0015335		hsa_circ_RABGAP1L	RABGAP1L	cerebral small vessel disease-associated cognitive impairment / CSVD-CI	MONDO:0010829	CARASIL syndrome	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0015335 is down-regulated in whole blood of CSVD-CI patients versus CSVD-CN and correlates with cognitive test performance. Statistical interaction/mediation analyses link hsa_circ_0015335 with DHCR24 and with brain cortical structural measures and plasma 24(S)-OHC, suggesting involvement in cholesterol/steroid metabolism-related cognitive impairment in CSVD."	0.5047
39578820	Experimental hematology & oncology	2024	CUL4A-DDB1-circRFWD2 E3 ligase complex mediates the ubiquitination of p27 to promote multiple myeloma proliferation.	hsa_circ_0015361	circRFWD2	hsa_circ_RFWD2	RFWD2	multiple myeloma / MM	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR	"circRFWD2 is up-regulated in multiple myeloma patient samples and higher levels correlate with inferior event-free survival. It can be translated into circRFWD2_369aa, which interacts with DDB1 and CUL4A to form an E3 ligase complex that promotes p27 ubiquitination/degradation, thereby enhancing MM cell proliferation and reducing apoptosis."	0.8347
39580381	"Molecular medicine (Cambridge, Mass.)"	2024	Mbnl1-mediated alternative splicing of circMlxipl regulates Rbbp6-involved ChREBP turnover to inhibit lipotoxicity-induced beta-cell damage.		circMlxipl	mmu_circ_Mlxipl	Mlxipl	type 2 diabetes mellitus / T2DM / diabetes	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RT-qPCR	"circMlxipl is down-regulated in diabetic mouse islets and PA-induced lipotoxic Min6 beta-cells. Its overexpression protects beta-cells (improves viability/proliferation, reduces apoptosis, increases insulin secretion) by associating with Rbbp6 to facilitate ubiquitin_proteasome turnover of ChREBP; its formation is promoted by Mbnl1-mediated back-splicing and indirectly controlled by Hdac3 via Mbnl1 repression."	0.8437
39580569	Discover oncology	2024	Hsa_circ_0072732 enhances sunitinib resistance of renal cell carcinoma by inhibiting ferroptosis.	hsa_circ_0072732				renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"Hsa_circ_0072732 is up-regulated in RCC cells and promotes sunitinib resistance. Mechanistically, it localizes mainly in the cytoplasm and functions as a miRNA sponge for miR-548b-3p, thereby increasing SLC7A11 expression to suppress ferroptosis under sunitinib treatment."	0.7666
39581695	Clinical and translational medicine	2024	CircSpna2 attenuates cuproptosis by mediating ubiquitin ligase Keap1 to regulate the Nrf2-Atp7b signalling axis in depression after traumatic brain injury in a mouse model.	mmu_circ_0009804	circSpna2	mmu_circ_Spna2	spna2	depression after traumatic brain injury	MONDO:0002050	depressive disorder	down-regulated	RT-qPCR; RNA-seq	"In the TBI mouse model, circSpna2 is down-regulated and its overexpression alleviates depression-like behaviours and reduces cuproptosis-associated mitochondrial and synaptic damage. Mechanistically, circSpna2 binds Keap1 (DGR domain) to inhibit Keap1-mediated ubiquitination of Nrf2, enhancing Nrf2-driven Atp7b transcription to improve copper homeostasis."	0.7991
39581695	Clinical and translational medicine	2024	CircSpna2 attenuates cuproptosis by mediating ubiquitin ligase Keap1 to regulate the Nrf2-Atp7b signalling axis in depression after traumatic brain injury in a mouse model.	hsa_circ_0088825		hsa_circ_SPNA2	SPNA2	depression after traumatic brain injury	MONDO:0002050	depressive disorder	down-regulated	RT-qPCR	"hsa_circ_0088825 is down-regulated in TBI patient brain tissue and plasma, and lower levels are associated with more severe depressive symptoms; ROC analysis suggests potential diagnostic utility for post-TBI depression."	0.4187
39587118	Scientific reports	2024	EIF4A3-induced hsa_circ_0127071 promotes human glomerular mesangial cells senescence via JAK2/STAT5 signaling pathway.	hsa_circ_0127071		hsa_circ_SCD5	SCD5	renal aging	MONDO:0005240	kidney disorder	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0127071 is up-regulated in aged human kidney cortex tissues and promotes HGMC senescence. EIF4A3 binds and increases hsa_circ_0127071 expression, which in turn activates JAK2/STAT5 signaling and is reported to act as a sponge for miR-665, thereby enhancing cellular aging markers."	0.866
39590363	Current issues in molecular biology	2024	Construction of Immune-Related circRNA-miRNA-mRNA Network and Identification of circRNAs as Biomarkers in Coronary Atherosclerotic Heart Disease.		hsa_circRNA_101069			Coronary atherosclerotic heart disease	MONDO:0850371	nonobstructive coronary artery disease	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_101069 is up-regulated in CHD blood samples and shows diagnostic utility. In ox-LDL-induced THP-1 macrophages, knockdown of hsa_circRNA_101069 reduces inflammatory cytokines (TNF-alpha, IL-6, IL-1beta) and apoptosis, suggesting a pro-inflammatory/pro-apoptotic role in an atherosclerosis-related cell model; it was identified within an immune-related ceRNA network but specific miRNA targets were not experimentally confirmed."	0.6949
39590363	Current issues in molecular biology	2024	Construction of Immune-Related circRNA-miRNA-mRNA Network and Identification of circRNAs as Biomarkers in Coronary Atherosclerotic Heart Disease.		hsa_circRNA_406053			Coronary atherosclerotic heart disease	MONDO:0850371	nonobstructive coronary artery disease	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_406053 is significantly up-regulated in CHD blood samples and is an independent risk factor for CHD. It shows diagnostic discrimination by ROC and improves risk reclassification (IDI/NRI) when added to traditional CHD risk factors; it was identified as part of an immune-related ceRNA network, but its specific regulatory targets were not experimentally validated."	0.5534
39590839	Metabolites	2024	Profiling of Metabolome in the Plasma Following a circH19 Knockdown Intervention in Diet-Induced Obese Mice.	hsa_circ_0095570	circH19 / hsa_circH19	hsa_circ_H19	H19	obesity	MONDO:0011122	obesity disorder	unknown	RT-qPCR	"In a high-fat diet diet-induced obese mouse model, circH19 knockdown reduced circulating circH19 and alleviated obesity-associated lipid deposition and dyslipidemia. Plasma metabolomics indicated broad metabolic remodeling, particularly involving lipid metabolism and amino-acid turnover, suggesting circH19 as a regulator of systemic metabolism in obesity."	0.5074
39596524	International journal of molecular sciences	2024	Oxidative Stress-Associated Alteration of circRNA and Their ceRNA Network in Differentiating Neuroblasts.		circTCONS_l2_00000968			oxidative stress	MONDO:0002602	central nervous system disorder	dysregulated	RNA-seq	"circTCONS_l2_00000968 is reported as a significantly altered circRNA in the pre-differentiation oxidative stress (PD-OS) model of differentiating SH-SY5Y neuroblasts, based on RNA-seq differential expression analysis."	0.1768
39596524	International journal of molecular sciences	2024	Oxidative Stress-Associated Alteration of circRNA and Their ceRNA Network in Differentiating Neuroblasts.		circSCARNA10	hsa_circ_SCARNA10	SCARNA10	oxidative stress	MONDO:0002602	central nervous system disorder	dysregulated	RNA-seq	"circSCARNA10 is one of the circRNAs reported to be significantly altered under pre-differentiation oxidative stress (PD-OS) in SH-SY5Y cells, identified by RNA-seq differential expression analysis."	0.1768
39596524	International journal of molecular sciences	2024	Oxidative Stress-Associated Alteration of circRNA and Their ceRNA Network in Differentiating Neuroblasts.		circCCDC90B	hsa_circ_CCDC90B	CCDC90B	oxidative stress	MONDO:0002602	central nervous system disorder	dysregulated	RNA-seq	"circCCDC90B is reported as significantly altered in the PD-OS oxidative stress paradigm in differentiating SH-SY5Y cells, based on RNA-seq differential expression results."	0.1768
39596524	International journal of molecular sciences	2024	Oxidative Stress-Associated Alteration of circRNA and Their ceRNA Network in Differentiating Neuroblasts.		circC7orf44	hsa_circ_C7orf44	C7orf44	oxidative stress	MONDO:0002602	central nervous system disorder	dysregulated	RNA-seq	"circC7orf44 is identified as a circRNA significantly altered in the PD-OS oxidative stress condition in SH-SY5Y cells, based on RNA-seq analysis."	0.1768
39596524	International journal of molecular sciences	2024	Oxidative Stress-Associated Alteration of circRNA and Their ceRNA Network in Differentiating Neuroblasts.		circSIPA1L3	hsa_circ_SIPA1L3	SIPA1L3	oxidative stress	MONDO:0002602	central nervous system disorder	dysregulated	RNA-seq	"circSIPA1L3 is reported as significantly altered in the during-differentiation oxidative stress (DD-OS) model in SH-SY5Y cells, based on RNA-seq differential expression analysis."	0.1768
39596524	International journal of molecular sciences	2024	Oxidative Stress-Associated Alteration of circRNA and Their ceRNA Network in Differentiating Neuroblasts.		circCANX	hsa_circ_CANX	CANX	oxidative stress	MONDO:0002602	central nervous system disorder	dysregulated	RNA-seq	"circCANX is identified as a circRNA significantly altered in the DD-OS oxidative stress condition in differentiating SH-SY5Y neuroblasts, based on RNA-seq analysis."	0.1768
39596524	International journal of molecular sciences	2024	Oxidative Stress-Associated Alteration of circRNA and Their ceRNA Network in Differentiating Neuroblasts.		circANKRD17	hsa_circ_ANKRD17	ANKRD17	oxidative stress	MONDO:0002602	central nervous system disorder	dysregulated	RNA-seq	"circANKRD17 (chr4:73956384|73958017) is the only circRNA reported as common to both PD-OS and DD-OS oxidative stress conditions in SH-SY5Y cells, indicating it responds to oxidative stress across both paradigms."	0.1768
39596524	International journal of molecular sciences	2024	Oxidative Stress-Associated Alteration of circRNA and Their ceRNA Network in Differentiating Neuroblasts.	hsa_circ_0004058	circZNF292	hsa_circ_ZNF292	ZNF292	oxidative stress	MONDO:0002602	central nervous system disorder	unknown	RNA-seq	"circZNF292 is a key hub circRNA in the PD-OS ceRNA network in SH-SY5Y cells, predicted to sponge miR-222-3p and be linked to regulation of the mRNA C11orf88 within circRNA_miRNA_mRNA axes."	0.1768
39596524	International journal of molecular sciences	2024	Oxidative Stress-Associated Alteration of circRNA and Their ceRNA Network in Differentiating Neuroblasts.		circBPTF / circ-BPTF	hsa_circ_BPTF	BPTF	oxidative stress	MONDO:0002602	central nervous system disorder	unknown	RNA-seq	"circBPTF is a top hub circRNA in the PD-OS ceRNA network in SH-SY5Y cells, predicted to regulate AJAP1 via sponging miR-138-5p as part of a circRNA_miRNA_mRNA regulatory axis."	0.1768
39596524	International journal of molecular sciences	2024	Oxidative Stress-Associated Alteration of circRNA and Their ceRNA Network in Differentiating Neuroblasts.		circFAM193B	hsa_circ_FAM193B	FAM193B	oxidative stress	MONDO:0002602	central nervous system disorder	unknown	RNA-seq	"circFAM193B is identified as a top hub circRNA in the PD-OS ceRNA network in SH-SY5Y cells, implying a central predicted regulatory role via circRNA_miRNA_mRNA interactions under oxidative stress."	0.1768
39596524	International journal of molecular sciences	2024	Oxidative Stress-Associated Alteration of circRNA and Their ceRNA Network in Differentiating Neuroblasts.		circZC3H13	hsa_circ_ZC3H13	ZC3H13	oxidative stress	MONDO:0002602	central nervous system disorder	unknown	RNA-seq	"circZC3H13 is a top hub circRNA in the DD-OS ceRNA network in SH-SY5Y cells, predicted to sponge miR-15a-5p and associate with regulation of PPM1H within a circRNA_miRNA_mRNA axis under oxidative stress during differentiation."	0.1768
39596524	International journal of molecular sciences	2024	Oxidative Stress-Associated Alteration of circRNA and Their ceRNA Network in Differentiating Neuroblasts.		circSFMBT2	hsa_circ_SFMBT2	SFMBT2	oxidative stress	MONDO:0002602	central nervous system disorder	unknown	RNA-seq	"circSFMBT2 is identified as a top hub circRNA in the DD-OS ceRNA network in SH-SY5Y cells, suggesting a central predicted role in oxidative-stress-associated circRNA_miRNA_mRNA regulation during differentiation."	0.1768
39596524	International journal of molecular sciences	2024	Oxidative Stress-Associated Alteration of circRNA and Their ceRNA Network in Differentiating Neuroblasts.		circCPT1A	hsa_circ_CPT1A	CPT1A	oxidative stress	MONDO:0002602	central nervous system disorder	unknown	RNA-seq	"circCPT1A is identified as a top hub circRNA in the DD-OS ceRNA network in SH-SY5Y cells, implying a central predicted role in oxidative-stress-associated post-transcriptional regulation via circRNA_miRNA_mRNA interactions."	0.1768
39601144	Clinical and translational medicine	2024	CircHipk3 serves a dual role in macrophage pyroptosis by promoting NLRP3 transcription and inhibition of autophagy to induce abdominal aortic aneurysm formation.		CircHipk3 / CirHipk3	hsa_circ_Hipk3	Hipk3	abdominal aortic aneurysm / AAA	MONDO:0005350	abdominal aortic aneurysm	up-regulated	RT-qPCR; ISH	"CircHipk3 is up-regulated in AAA aortic tissue and primarily localizes to the macrophage cytoplasm. It promotes macrophage pyroptosis and AAA progression by interacting with Stat3 to increase NLRP3 inflammasome production and by binding Snd1 to affect Ptbp1 mRNA degradation, inhibiting autophagy and reducing NLRP3 clearance."	0.8355
39601144	Clinical and translational medicine	2024	CircHipk3 serves a dual role in macrophage pyroptosis by promoting NLRP3 transcription and inhibition of autophagy to induce abdominal aortic aneurysm formation.	mmu_circ_0001052	CircHipk3 / CirHipk3	mmu_circ_Hipk3	Hipk3	abdominal aortic aneurysm / AAA	MONDO:0005350	abdominal aortic aneurysm	up-regulated	RT-qPCR; ISH	"CircHipk3 is up-regulated in AAA aortic tissue and primarily localizes to the macrophage cytoplasm. It promotes macrophage pyroptosis and AAA progression by interacting with Stat3 to increase NLRP3 inflammasome production and by binding Snd1 to affect Ptbp1 mRNA degradation, inhibiting autophagy and reducing NLRP3 clearance."	0.8355
39601341	Journal of cellular and molecular medicine	2024	The Prognostic Potential of circRNAs in Multiple Myeloma: Insights From Whole Bone Marrow and Purified Plasma Cells.		circFUT8	hsa_circ_FUT8	FUT8	Multiple myeloma / MM	MONDO:0009693	plasma cell myeloma	unknown	RNA-seq	"In whole bone marrow samples from MM patients, circFUT8 expression level was significantly associated with overall survival; higher circFUT8 expression indicated a more favourable prognosis."	0.2995
39601341	Journal of cellular and molecular medicine	2024	The Prognostic Potential of circRNAs in Multiple Myeloma: Insights From Whole Bone Marrow and Purified Plasma Cells.		circZNF532	hsa_circ_ZNF532	ZNF532	Multiple myeloma / MM	MONDO:0009693	plasma cell myeloma	unknown	RNA-seq	"In whole bone marrow MM samples, circZNF532 expression was prognostic: lower circZNF532 expression was associated with better survival (thus higher expression indicated worse prognosis)."	0.2995
39601341	Journal of cellular and molecular medicine	2024	The Prognostic Potential of circRNAs in Multiple Myeloma: Insights From Whole Bone Marrow and Purified Plasma Cells.		circMETTL3	hsa_circ_METTL3	METTL3	Multiple myeloma / MM	MONDO:0009693	plasma cell myeloma	unknown	RNA-seq	"In MM whole bone marrow cohort, circMETTL3 was among the most significant prognostic circRNAs; higher expression was associated with better overall survival."	0.2995
39601341	Journal of cellular and molecular medicine	2024	The Prognostic Potential of circRNAs in Multiple Myeloma: Insights From Whole Bone Marrow and Purified Plasma Cells.		circELK4	hsa_circ_ELK4	ELK4	Multiple myeloma / MM	MONDO:0009693	plasma cell myeloma	unknown	RNA-seq	"In the MM whole bone marrow cohort, circELK4 expression was prognostic: lower expression was associated with better survival (thus higher expression indicated worse prognosis)."	0.2995
39601341	Journal of cellular and molecular medicine	2024	The Prognostic Potential of circRNAs in Multiple Myeloma: Insights From Whole Bone Marrow and Purified Plasma Cells.		circMAN1A2	hsa_circ_MAN1A2	MAN1A2	Multiple myeloma / MM	MONDO:0009693	plasma cell myeloma	unknown	RNA-seq	"In CD138-purified plasma cells from MM patients, higher circMAN1A2 expression was associated with better overall survival, indicating prognostic biomarker potential."	0.2995
39601341	Journal of cellular and molecular medicine	2024	The Prognostic Potential of circRNAs in Multiple Myeloma: Insights From Whole Bone Marrow and Purified Plasma Cells.		circPCMTD1	hsa_circ_PCMTD1	PCMTD1	Multiple myeloma / MM	MONDO:0009693	plasma cell myeloma	unknown	RNA-seq	"In CD138-purified plasma cells from MM patients, higher circPCMTD1 expression was associated with better overall survival, supporting its prognostic biomarker value."	0.2995
39601341	Journal of cellular and molecular medicine	2024	The Prognostic Potential of circRNAs in Multiple Myeloma: Insights From Whole Bone Marrow and Purified Plasma Cells.		circZNF609	hsa_circ_ZNF609	ZNF609	Multiple myeloma / MM	MONDO:0009693	plasma cell myeloma	unknown	RNA-seq	"In CD138-purified plasma cell samples from MM patients, higher circZNF609 expression was associated with better survival, suggesting prognostic biomarker potential."	0.2995
39601341	Journal of cellular and molecular medicine	2024	The Prognostic Potential of circRNAs in Multiple Myeloma: Insights From Whole Bone Marrow and Purified Plasma Cells.		ciRS-7	hsa_circ_CDR1AS		Multiple myeloma / MM	MONDO:0009693	plasma cell myeloma	unknown	RT-qPCR; RNA-seq	"In purified plasma cell MM samples, ciRS-7 expression measured by RNA-seq was confirmed by RT-qPCR, serving as an experimentally validated circRNA readout in the context of proliferation_circRNA level associations (no specific mechanism or prognostic direction was provided)."	0.1904
39609379	Translational psychiatry	2024	"Aberrant encoding of event saliency in the orbitofrontal cortex following loss of the psychiatric-associated circular RNA, circHomer1."			mmu_circ_Homer1	Homer1	schizophrenia / SCZ	MONDO:0005090	schizophrenia	down-regulated	RT-qPCR	"circHomer1 loss in mouse orbitofrontal cortex disrupts cognitive flexibility by shifting choice-related neural signaling toward cue-responding and altering coordinated oscillatory activity (ITPC/power). Its knockdown is associated with reduced expression of glutamatergic synaptic regulators, suggesting circHomer1 helps maintain synaptic signaling programs relevant to psychiatric phenotypes."	0.5218
39612054	Journal of molecular histology	2024	Circular RNA circVAPA mediates alveolar macrophage activation by modulating miR-212-3p/Sirt1 axis in acute respiratory distress syndrome.		circVAPA	hsa_circ_VAPA	VAPA	acute respiratory distress syndrome / ARDS	MONDO:0006502	acute respiratory distress syndrome	up-regulated	RT-qPCR	"circVAPA is upregulated in alveolar macrophages from ARDS patients and in LPS-induced mouse macrophages. circVAPA promotes macrophage inflammatory polarization and inflammasome/pyroptosis activation by regulating the miR-212-3p/Sirt1 axis, and its knockdown alleviates lung inflammation and tissue injury in an LPS-induced mouse ARDS model."	0.6545
39612054	Journal of molecular histology	2024	Circular RNA circVAPA mediates alveolar macrophage activation by modulating miR-212-3p/Sirt1 axis in acute respiratory distress syndrome.		circVAPA	mmu_circ_VAPA	VAPA	acute respiratory distress syndrome / ARDS	MONDO:0006502	acute respiratory distress syndrome	up-regulated	RT-qPCR	"circVAPA is upregulated in alveolar macrophages from ARDS patients and in LPS-induced mouse macrophages. circVAPA promotes macrophage inflammatory polarization and inflammasome/pyroptosis activation by regulating the miR-212-3p/Sirt1 axis, and its knockdown alleviates lung inflammation and tissue injury in an LPS-induced mouse ARDS model."	0.6545
39616161	Cell death & disease	2024	"A N7-methylguanosine modified circular RNA, circIPP2A2, promotes malignant behaviors in hepatocellular carcinoma by serving as a scaffold in modulating the Hornerin/PI3K/AKT/GSK3beta axis."		circIPP2A2 / IPPA22	hsa_circ_SET	SET	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circIPP2A2 is up-regulated in HCC and promotes tumor growth and metastasis. METTL1-mediated m7G modification increases circIPP2A2 stability and supports its binding, enabling circIPP2A2 to act as a scaffold that strengthens Hornerin_PI3K interaction and activates PI3K/AKT/GSK3beta signaling. High circIPP2A2 expression is associated with worse postoperative survival."	0.8785
39617640	"Cancer reports (Hoboken, N.J.)"	2024	"Bioinformatics and Experimental Insights Into miR-182, hsa_circ_0070269, and circ-102,166 as Therapeutic Targets for HCV-Associated HCC."	hsa_circ_0070269				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"In HCV-induced HCC patient blood, hsa_circ_0070269 is significantly down-regulated. The study supports a tumor-suppressive ceRNA role where hsa_circ_0070269 sponges miR-182, relieving repression of NPTX1, and proposes it as a diagnostic biomarker/therapeutic target."	0.348
39617640	"Cancer reports (Hoboken, N.J.)"	2024	"Bioinformatics and Experimental Insights Into miR-182, hsa_circ_0070269, and circ-102,166 as Therapeutic Targets for HCV-Associated HCC."	hsa_circ_0004913	"circ_102,166 "			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"In HCV-induced HCC patient blood, circ-102,166 (hsa_circ_0004913) is significantly down-regulated. The work supports a tumor-suppressive ceRNA model where circ-102,166 sponges miR-182 to increase MTSS1 and FOXO3a, and proposes it as a diagnostic biomarker/therapeutic target."	0.348
39618927	Journal of inflammation research	2024	Differential Expressions of circRNAs and Regulatory Mechanisms of ceRNA Network in Liver of Wilson's Disease TX Mice.	mmu_circ_0000897				Wilson¡¯s disease / WD	MONDO:0010200	Wilson disease	up-regulated	RT-qPCR; RNA-seq	"In TX-j mice with WD-induced liver fibrosis, mmu_circ_0000897 is significantly up-regulated and was confirmed by RT-qPCR following RNA-seq identification. No specific downstream miRNA/mRNA targets or mechanisms were experimentally validated for this circRNA in the paper."	0.3213
39618927	Journal of inflammation research	2024	Differential Expressions of circRNAs and Regulatory Mechanisms of ceRNA Network in Liver of Wilson's Disease TX Mice.	mmu_circ_0000943				Wilson¡¯s disease / WD	MONDO:0010200	Wilson disease	up-regulated	RT-qPCR; RNA-seq	"In TX-j mice with WD-induced liver fibrosis, mmu_circ_0000943 is significantly up-regulated and was confirmed by RT-qPCR following RNA-seq identification. The study did not report specific validated miRNA/mRNA targets or functional assays for this circRNA."	0.3213
39618927	Journal of inflammation research	2024	Differential Expressions of circRNAs and Regulatory Mechanisms of ceRNA Network in Liver of Wilson's Disease TX Mice.	mmu_circ_0001829		mmu_circ_Rasa2	Rasa2	Wilson¡¯s disease / WD	MONDO:0010200	Wilson disease	up-regulated	RT-qPCR; RNA-seq	"mmu_circ_0001829 (host gene Rasa2) is up-regulated in liver tissue of TX-j mice with WD-induced liver fibrosis, validated by RT-qPCR. The study further included it among differentially expressed circRNAs used to build a predicted circRNA_miRNA_mRNA (ceRNA) network, but did not experimentally validate specific targets for this circRNA."	0.3684
39618927	Journal of inflammation research	2024	Differential Expressions of circRNAs and Regulatory Mechanisms of ceRNA Network in Liver of Wilson's Disease TX Mice.	mmu_circ_0000847				Wilson¡¯s disease / WD	MONDO:0010200	Wilson disease	down-regulated	RT-qPCR; RNA-seq	"In TX-j mice with WD-induced liver fibrosis, mmu_circ_0000847 is significantly down-regulated and was confirmed by RT-qPCR following RNA-seq identification. No specific mechanism or targets were experimentally validated for this circRNA in the paper."	0.3213
39618927	Journal of inflammation research	2024	Differential Expressions of circRNAs and Regulatory Mechanisms of ceRNA Network in Liver of Wilson's Disease TX Mice.	mmu_circ_0001017		mmu_circ_Acvr2a	Acvr2a	Wilson¡¯s disease / WD	MONDO:0010200	Wilson disease	down-regulated	RT-qPCR; RNA-seq	mmu_circ_0001017 (host gene Acvr2a) is significantly down-regulated in liver tissue of TX-j mice with WD-induced liver fibrosis and was confirmed by RT-qPCR. The paper did not provide experimentally validated downstream interaction partners for this circRNA.	0.3213
39618927	Journal of inflammation research	2024	Differential Expressions of circRNAs and Regulatory Mechanisms of ceRNA Network in Liver of Wilson's Disease TX Mice.	mmu_circ_0000652				Wilson¡¯s disease / WD	MONDO:0010200	Wilson disease	down-regulated	RT-qPCR; RNA-seq	"In TX-j mice with WD-induced liver fibrosis, mmu_circ_0000652 is significantly down-regulated and was confirmed by RT-qPCR following RNA-seq identification. The study did not provide validated targets, pathways, or functional experiments for this circRNA."	0.3213
39620490	Thoracic cancer	2025	Circ_0096710 facilitates tumor growth via controlling ADAM10 expression in esophageal squamous cell carcinoma.	hsa_circ_0096710	circ_0096710	hsa_circ_NOX4	NOX4	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"circ_0096710 is upregulated in ESCC and promotes malignant phenotypes and xenograft tumor growth. Mechanistically, it acts as a cytoplasmic ceRNA that sponges miR-1294 to increase ADAM10 expression, and high circ_0096710 is associated with worse patient survival and diagnostic potential."	0.8449
39621506	Thoracic cancer	2025	"circ-TTC17 Promotes Esophagus Squamous Cell Carcinoma Cell Growth, Metastasis, and Inhibits Autophagy-Mediated Radiosensitivity Through miR-145-5p/SIRT1 Axis."		circ_TTC17 / circ-TTC17	hsa_circ_TTC17	TTC17	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"circ-TTC17 is up-regulated in ESCC tissues and cell lines and acts as an oncogenic circRNA. It sponges miR-145-5p to relieve repression of SIRT1, promoting proliferation and metastasis and reducing apoptosis, while promoting autophagy and thereby decreasing radiosensitivity; circ-TTC17 knockdown suppresses xenograft tumor growth."	0.6831
39621727	PloS one	2024	GLP-1RA improves diabetic renal injury by alleviating glomerular endothelial cells pyrotosis via RXRalpha/circ8411/miR-23a-5p/ABCA1 pathway.		circ8411			diabetic kidney disease / DKD	MONDO:0005016	diabetic kidney disease	dysregulated	RT-qPCR; Microarray	"In DKD-related lipotoxic injury models, circ8411 alleviates cholesterol accumulation and pyroptosis in glomerular endothelial cells by acting as a ceRNA that sponges miR-23a-5p and thereby increases ABCA1. High glucose suppresses circ8411 via RXRalpha, while GLP-1RAs restore this RXRalpha/circ8411/miR-23a-5p/ABCA1 axis to confer renal protection."	0.5997
39624324	Heliyon	2024	CircZMYM2 plays a pivotal role in osteosarcoma by regulating the translation of NACA and ARPC1B.	hsa_circ_0029634	circZMYM2	hsa_circ_ZMYM2	ZMYM2	Osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"circZMYM2 (hsa_circ_0029634), derived from ZMYM2, is up-regulated in osteosarcoma tissues and mainly localizes to the cytoplasm. It promotes osteosarcoma proliferation and metastasis by competitively binding the RBP FXR1, thereby modulating translation of NACA and ARPC1B; its biogenesis is promoted by NCBP2 binding to flanking intronic regions."	0.8397
39624576	International journal of genomics	2024	Identification of the hsa_circ_0001314-Related ceRNA Network in Breast Cancer With Bioinformatics Analysis.	hsa_circ_0001314	hsa_circ_001831 / hsa_circ_001314			breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"In breast cancer, hsa_circ_0001314 is up-regulated in tissues and cell lines. Its knockdown suppresses proliferation, migration and invasion while promoting apoptosis. Mechanistically, it acts as a ceRNA sponging hsa-miR-548aj-3p to increase MAPK8/MAP3K1 and activate MAPK signaling, suggesting biomarker/therapeutic potential."	0.6093
39624827	ImmunoTargets and therapy	2024	Circ_0001944 Targets the miR-1292-5p/FBLN2 Axis to Facilitate Sorafenib Resistance in Hepatocellular Carcinoma by Impeding Ferroptosis.	hsa_circ_0001944	circ_0001944			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"In sorafenib-resistant HCC cells, circ_0001944 is up-regulated and promotes sorafenib resistance. It directly targets miR-1292-5p to regulate the miR-1292-5p/FBLN2 axis, leading to suppression of ferroptosis (reduced iron overload/ROS/lipid peroxidation)."	0.7164
39628959	Breast cancer (Dove Medical Press)	2024	Identification and Validation of circDOCK1/miR-138-5p/GRB7 Axis for Promoting Breast Cancer Progression.		circDOCK1 / cirDOCK1	hsa_circ_DOCK1	DOCK1	HER2-positive breast cancer	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	"circDOCK1 is up-regulated in HER2-positive breast cancer and promotes migration/invasion and metastatic progression. Mechanistically, circDOCK1 acts as a ceRNA by sponging miR-138-5p to increase GRB7 expression. High circDOCK1 expression correlates with adverse clinicopathologic features and poorer DFS/OS."	0.7474
39632246	Physiological reports	2024	Circ_0089761 accelerates colorectal cancer metastasis and immune escape via miR-27b-3p/PD-L1 axis.	hsa_circ_0089761	circ_0089761			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0089761 is up-regulated in colorectal cancer and promotes malignant phenotypes (proliferation, migration/invasion, EMT) while inhibiting apoptosis. It acts as a ceRNA by sponging miR-27b-3p to increase PD-L1, thereby enhancing immune escape by impairing CD8+ T-cell function. High circ_0089761 expression correlates with advanced stage, larger tumor size, poorer overall survival, and shows diagnostic potential."	0.753
39632285	Journal of cellular and molecular medicine	2024	WTAP-Mediated m6A Modification of circSMOC1 Accelerates the Tumorigenesis of Non-Small Cell Lung Cancer by Regulating miR-612/CCL28 Axis.	hsa_circ_0032363	circSMOC1	hsa_circ_SMOC1	SMOC1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circSMOC1 is up-regulated in NSCLC/LAC and correlates with advanced TNM stage and poor overall survival. Functionally, circSMOC1 promotes proliferation/colony formation and invasion while inhibiting apoptosis, and its knockdown suppresses xenograft tumor growth. Mechanistically, WTAP-mediated m6A modification supports circSMOC1, which sponges miR-612 to de-repress/upregulate CCL28."	0.8768
39633556	Haematologica	2025	Depletion of the RNA binding protein QKI and circular RNA dysregulation in T-cell acute lymphoblastic leukemia.		CircTASP1	hsa_circ_TASP1	TASP1	T-cell acute lymphoblastic leukemia / T-ALL	MONDO:0004963	T-cell acute lymphoblastic leukemia	up-regulated	RT-qPCR; RNA-seq	"circTASP1 is up-regulated in QKI-reduced T-ALL and increases upon QKI silencing in T-ALL cell lines, indicating QKI-dependent control of its circularization/expression (indirect relationship). No downstream miRNA/mRNA axis or specific pathway was established in this study."	0.3213
39633556	Haematologica	2025	Depletion of the RNA binding protein QKI and circular RNA dysregulation in T-cell acute lymphoblastic leukemia.		circPHACTR4 / circPHACT4	hsa_circ_PHACTR4	PHACTR4	T-cell acute lymphoblastic leukemia / T-ALL	MONDO:0004963	T-cell acute lymphoblastic leukemia	down-regulated	RT-qPCR; RNA-seq	"circPHACTR4 is down-regulated in QKI-reduced T-ALL and decreases upon QKI knockdown while increasing with QKI overexpression, supporting direct QKI-dependent control. Its reduction is uncoupled from the linear transcript, suggesting post-transcriptional regulation of backsplicing/biogenesis rather than transcriptional change."	0.3213
39634903	Pakistan journal of medical sciences	2024	A nested case-control study of circular ribonucleic acid expression profiles in the peripheral blood of pregnant women with pre-eclampsia.	hsa_circ_0065049				preeclampsia / PE	MONDO:0005081	preeclampsia	unknown	Microarray	"This study identified hsa_circ_0065049 as part of a predicted circRNA-miRNA-mRNA regulatory network in peripheral blood prior to PE onset. hsa_circ_0065049 is predicted to bind miR-17-3p (and other miRNAs) and thereby influence target mRNA expression, potentially impacting processes such as trophoblast proliferation/apoptosis and angiogenesis-related remodeling relevant to PE."	0.1768
39634903	Pakistan journal of medical sciences	2024	A nested case-control study of circular ribonucleic acid expression profiles in the peripheral blood of pregnant women with pre-eclampsia.	hsa_circ_0005567				preeclampsia / PE	MONDO:0005081	preeclampsia	unknown	Microarray	"This study highlights hsa_circ_0005567 as a predicted PE-related circRNA in peripheral blood before disease onset. Bioinformatics prediction suggests it binds miR-24-3p (and other miRNAs) to influence target mRNA expression, potentially affecting trophoblast-related processes and angiogenesis relevant to PE development."	0.1768
39636111	Journal of virology	2025	The neurological damage caused by enterovirus 71 infection is associated with hsa_circ_0069335/miR-29b/PMP22 pathway.	hsa_circ_0069335				enterovirus 71 infection / EV71 infection	MONDO:0005747	enterovirus infectious disease	dysregulated	RT-qPCR; RNA-seq	"The study identifies hsa_circ_0069335 as an EV71-regulated circRNA in Schwann cells that directly binds and co-localizes with miR-29b. It proposes that hsa_circ_0069335 may modulate the miR-29b/PMP22 axis, contributing to Schwann-cell dysfunction and EV71-associated neurological damage."	0.6183
39641304	The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology	2024	hsa_circ_0000520 Serves as a Prognostic Biomarker for Colorectal Cancer and Promotes in the Disease Progression.	hsa_circ_0000520	circ_0000520 / circ-0000520			Colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"hsa_circ_0000520 is up-regulated in colorectal cancer tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion) while inhibiting apoptosis. Mechanistically, it acts as a miR-542-3p sponge to regulate MYH9, and high expression predicts poorer survival in CRC patients."	0.7396
39642324	Molecular cancer research : MCR	2025	Gut Microbiota-Mediated hsa_circ_0126925 Targets BCAA Metabolic Enzyme BCAT2 to Exacerbate Colorectal Cancer Progression.	hsa_circ_0126925	circ_0126925			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH	"In colorectal cancer, circ_0126925 is up-regulated and promotes proliferation, invasion, tumor growth and metastasis. Mechanistically, it binds mitochondrial BCAT2 and interferes with TRIM21-mediated ubiquitination/degradation of BCAT2, sustaining BCAA metabolism and enhancing ROS tolerance via NRF2/HO-1 signaling, thereby suppressing apoptosis. High circ_0126925 expression is associated with poor overall survival."	0.8634
39647239	Redox biology	2025	Macrophage metabolic reprogramming ameliorates diabetes-induced microvascular dysfunction.		circRNA-sperm antigen with calponin homology and coiled-coil domains 1 / cSPECC1	hsa_circ_SPECC1	SPECC1	diabetes-induced microvascular dysfunction	MONDO:0000960	diabetic peripheral angiopathy	up-regulated	RT-qPCR	"cSPECC1 is up-regulated in diabetic retinas and high-glucose-stressed macrophages and promotes M1-like macrophage activation and pro-angiogenic macrophage-endothelial crosstalk. Mechanistically, cSPECC1 binds/recruits eIF4A3 to enhance GPX2 mRNA stability, reshaping arachidonic acid metabolism and increasing 12-HETE, thereby exacerbating retinal inflammation and vascular dysfunction."	0.8219
39647532	Virus research	2024	CircPTPN11 inhibits the replication of Coxsackievirus B5 through regulating the IFN-I pathway by targeting miR-152-3p/SIRPA axis.		CircPTPN11	hsa_circ_PTPN11	PTPN11	Coxsackievirus Group B5 infection	MONDO:0005721	coxsackievirus infectious disease	up-regulated	RT-qPCR; RNA-seq	"CircPTPN11 is induced by CVB5 infection and mainly localizes to the cytoplasm. It suppresses CVB5 replication by sponging miR-152-3p to de-repress SIRPA, thereby activating IRF3 and enhancing type-I interferon signaling."	0.7548
39650233	Oncology letters	2025	Hsa_circ_0009910 knockdown in HeLa cells increases miR_198 expression levels and decreases c_Met expression levels and cell viability.	hsa_circ_0009910	circ9910	hsa_circ_MFN2	MFN2	Cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"In cervical cancer cell context (HeLa), hsa_circ_0009910 is up-regulated and promotes cell viability. Its knockdown increases miR-198 and decreases c-Met mRNA, supporting a ceRNA-like hsa_circ_0009910/miR-198/c-Met regulatory axis."	0.4062
39650787	International journal of general medicine	2024	Comprehensive Analysis of circRNA-Related mRNAs as Prognostic Factors in Non-Smoking Women with Lung Adenocarcinoma.	hsa_circ_0072309	circLIFR	hsa_circ_LIFR	LIFR	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RNA-seq; Microarray	"hsa_circ_0072309 (circLIFR) is down-regulated in tumor tissues from non-smoking women with lung adenocarcinoma. The study proposes a ceRNA mechanism where hsa_circ_0072309 sponges miR-32-5p to regulate PCMTD1, potentially affecting tumor proliferation and NK-cell-related activity."	0.2465
39650787	International journal of general medicine	2024	Comprehensive Analysis of circRNA-Related mRNAs as Prognostic Factors in Non-Smoking Women with Lung Adenocarcinoma.	hsa_circ_0009043				lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	Microarray	hsa_circ_0009043 is significantly down-regulated in tumor tissues of non-smoking women with lung adenocarcinoma in the external dataset validation step. The paper does not provide a specific miRNA/mRNA axis or functional mechanism for this circRNA.	0.1768
39654770	Heliyon	2024	Hsa_Circ_0105596/FTO inhibits progression of Parkinson's disease by sponging miR-187-3p and regulating eEF2.	hsa_circ_0105596	hsa_Circ_0105596 / circFTO	hsa_circ_FTO	FTO	Parkinson's disease / PD	MONDO:0005180	Parkinson disease	up-regulated	RT-qPCR; RNA-seq	"circFTO (Hsa_Circ_0105596) is up-regulated in Parkinson's disease and promotes disease-associated neuronal injury. Mechanistically, it sponges miR-187-3p, weakening miR-187-3p-mediated repression of EEF2, thereby enhancing apoptosis and oxidative/inflammatory stress; circFTO knockdown alleviates PD phenotypes in 6-OHDA models."	0.7302
39659575	Theranostics	2024	Circular RNA SCMH1 suppresses KMO expression to inhibit mitophagy and promote functional recovery following stroke.		circSCMH1 / circular RNA SCMH1	mmu_circ_SCMH1	SCMH1	ischemic stroke / IS	MONDO:1060198	ischemic stroke	unknown	RT-qPCR	"In a photothrombotic ischemic stroke mouse model, circSCMH1 delivered via RVG-engineered extracellular vesicles promotes post-stroke repair and motor recovery. It binds the transcription activator STAT5B, blocks STAT5B nuclear translocation, decreases Kmo/KMO expression, enhances mitochondrial fusion, and inhibits KMO-mediated mitophagy, reducing glial activation and supporting neuroplasticity/vascular remodeling."	0.6435
39664183	Frontiers in oncology	2024	circUBE2G1 interacts with hnRNPU to promote VEGF-C-mediated lymph node metastasis of lung adenocarcinoma.	hsa_circ_0041555	circUBE2G1	hsa_circ_UBE2G1	UBE2G1	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	circUBE2G1 (hsa_circ_0041555) is upregulated in LUAD and is associated with lymph node metastasis and poor survival. It predominantly localizes to the nucleus and promotes lymphangiogenesis and LN metastasis by binding hnRNPU and recruiting it to the VEGF-C promoter to increase H3K27ac and activate VEGF-C transcription/secretion.	0.897
39667201	"Clinics (Sao Paulo, Brazil)"	2025	CircRBM33 competitively binds miR-15a-5p to mediate EZH1 expression to ameliorate sepsis-induced acute lung injury.		circRBM33	mmu_circ_RBM33	RBM33	sepsis-induced acute lung injury / ALI	MONDO:0006502	acute respiratory distress syndrome	up-regulated	RT-qPCR	"circRBM33 is up-regulated in sepsis-induced ALI models and patient plasma. Silencing circRBM33 alleviates lung injury by reducing apoptosis, inflammatory cytokines and oxidative stress. Mechanistically, circRBM33 sponges miR-15a-5p to increase EZH1 expression (circRBM33/miR-15a-5p/EZH1 axis)."	0.7949
39684767	International journal of molecular sciences	2024	CircRNAs and miRNAs: Key Player Duo in Breast Cancer Dynamics and Biomarkers for Breast Cancer Early Detection and Prevention.	hsa_circ_0002599		hsa_circ_FUK	FUK	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	Microarray	hsa_circ_0002599 is down-regulated in breast cancer tissue in a circRNA microarray dataset and is proposed (via in silico prediction) to sponge hsa-miR-326-3p as part of the FUK/hsa_circ_0002599/hsa-miR-326-3p axis for early breast cancer initiation biomarker screening.	0.348
39684767	International journal of molecular sciences	2024	CircRNAs and miRNAs: Key Player Duo in Breast Cancer Dynamics and Biomarkers for Breast Cancer Early Detection and Prevention.	hsa_circ_0088251		hsa_circ_PAPPA	PAPPA	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	Microarray	hsa_circ_0088251 is down-regulated in breast cancer tissue in a circRNA microarray dataset and is proposed (via in silico prediction) to sponge hsa-miR-326-3p as part of the PAPPA/hsa_circ_0088251/hsa-miR-326-3p axis for early breast cancer initiation biomarker screening.	0.348
39684767	International journal of molecular sciences	2024	CircRNAs and miRNAs: Key Player Duo in Breast Cancer Dynamics and Biomarkers for Breast Cancer Early Detection and Prevention.	hsa_circ_0044556		hsa_circ_COL1A1	COL1A1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	Microarray	hsa_circ_0044556 is up-regulated in breast cancer tissue in a circRNA microarray dataset and is proposed (via in silico prediction) to sponge hsa-miR-145-5p as part of the COL1A1/hsa_circ_0044556/hsa-miR-145-5p axis for early breast cancer initiation biomarker screening.	0.348
39684767	International journal of molecular sciences	2024	CircRNAs and miRNAs: Key Player Duo in Breast Cancer Dynamics and Biomarkers for Breast Cancer Early Detection and Prevention.	hsa_circ_0001875		hsa_circ_FAM120A	FAM120A	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	Microarray	hsa_circ_0001875 is up-regulated in breast cancer tissue in a circRNA microarray dataset and is proposed (via in silico prediction) to sponge hsa-miR-145-5p as part of the FAM120A/hsa_circ_0001875/hsa-miR-145-5p axis for early breast cancer initiation biomarker screening.	0.348
39684767	International journal of molecular sciences	2024	CircRNAs and miRNAs: Key Player Duo in Breast Cancer Dynamics and Biomarkers for Breast Cancer Early Detection and Prevention.	hsa_circ_0001414		hsa_circ_TMEM165	TMEM165	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	Microarray	hsa_circ_0001414 is up-regulated in breast cancer tissue in a circRNA microarray dataset and is proposed (via in silico prediction) to sponge hsa-miR-99a as part of the TMEM165/hsa_circ_0001414/hsa-miR-99a axis for early breast cancer initiation biomarker screening.	0.348
39689152	PLoS pathogens	2024	A previously unidentified circRNA inhibits virus replication by regulating the miR-24-3p/KEAP1 axis.		circ29164	ssc_circ_EZH2	EZH2	pseudorabies virus infection 	MONDO:0005108	viral infectious disease	up-regulated	RT-qPCR	"circ29164 is induced upon PRV infection in porcine cells and acts as an antiviral circRNA. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging ssc-miR-24-3p, thereby maintaining Keap1/KEAP1 expression, activating caspase-dependent mitochondrial apoptosis, and suppressing viral replication."	0.8058
39691598	Frontiers in oncology	2024	CircRNA_036186 mediates HNSCC progression by regulating 14-3-3zeta.	hsa_circ_0036186	CircRNA_036186 / hsa_circRNA_036186			Head and neck squamous cell carcinoma / HNSCC	MONDO:0010150	head and neck squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circRNA_036186 is up-regulated in HNSCC tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion). Mechanistically, it positively regulates 14-3-3zeta by sponging miR-193b-3p, forming a circRNA_036186/miR-193b-3p/14-3-3zeta ceRNA axis with potential diagnostic/therapeutic relevance in HNSCC."	0.6815
39692561	Technology in cancer research & treatment	2024	Plasma CircCYP24A1 as a Novel Biomarker of Esophageal Squamous Cell Carcinoma.		circCYP24A1	hsa_circ_CYP24A1	CYP24A1	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"CircCYP24A1 is significantly up-regulated in ESCC tissues and patient plasma, correlating with lymph node metastasis, advanced TNM stage, and poorer survival. Functionally, circCYP24A1 promotes ESCC cell migration, invasion, and EMT in vitro, and shows strong diagnostic performance in plasma (AUC 0.94) with predictive value for LNM (AUC 0.76)."	0.8283
39692840	Discover oncology	2024	Unveiling hsa_circ_0007439: a novel suppressor of nasopharyngeal carcinoma via miR-556-5p/PTEN Axis.	hsa_circ_0007439	Circ_0007439	hsa_circ_PPP1CB	PPP1CB	nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	down-regulated	RT-qPCR	"hsa_circ_0007439 (circ_0007439), derived from PPP1CB, is down-regulated in nasopharyngeal carcinoma tissues and cells. Its upregulation suppresses NPC cell viability/proliferation, migration and invasion and increases apoptosis by sponging miR-556-5p to de-repress PTEN (circ_0007439/miR-556-5p/PTEN axis)."	0.7295
39692846	Discover oncology	2024	Circular RNA NINL accelerates the malignant progression of cervical cancer.		circNINL / circ-NINL	hsa_circ_NINL	NINL	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circNINL is up-regulated in cervical cancer and mainly localized in the cytoplasm. It promotes malignant phenotypes (proliferation, migration/invasion and reduced apoptosis) by sponging miR-2467-3p to upregulate SP1, forming a circNINL/miR-2467-3p/SP1 ceRNA axis."	0.8122
39695693	Molecular cancer	2024	Circular RNA circPHLPP2 promotes tumor growth and anti-PD-1 resistance through binding ILF3 to regulate IL36gamma transcription in colorectal cancer.	hsa_circ_0003681	circPHLPP2	hsa_circ_PHLPP2	PHLPP2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circPHLPP2 (hsa_circ_0003681, from PHLPP2) is up-regulated in CRC, especially in anti-PD-1_resistant MSS/pMMR patients, and high expression predicts worse overall survival. Functionally, it promotes tumor growth in vivo and anti-PD-1 resistance by binding ILF3 to drive nuclear ILF3 accumulation and increase IL36gamma transcription, leading to reduced NK-cell infiltration and reduced granzyme B/IFN-gamma production."	0.8978
39695693	Molecular cancer	2024	Circular RNA circPHLPP2 promotes tumor growth and anti-PD-1 resistance through binding ILF3 to regulate IL36gamma transcription in colorectal cancer.	mmu_circ_0014549	circPhlpp2 / mouse circPhlpp2	mmu_circ_Phlpp2		colorectal cancer / CRC	MONDO:0005575	colorectal cancer	unknown	RT-qPCR; Microarray	"In mouse CRC syngeneic models (MC38/CT26), circPhlpp2 promotes tumor growth by shaping the immune microenvironment, decreasing NK-cell infiltration and NK-cell cytotoxic cytokines (granzyme B, IFN-gamma). circPhlpp2 knockdown improves response to anti-PD-1 treatment in vivo, and IL36gamma acts as a functional downstream mediator."	0.6474
39695793	Stem cell research & therapy	2024	Hypoxic mesenchymal stem cell-derived exosomal circDennd2a regulates granulosa cell glycolysis by interacting with LDHA.	hsa_circ_0002142	circDennd2a / HM-Exs-circDennd2a	hsa_circ_Dennd2a	Dennd2a	Premature ovarian insufficiency / POI	MONDO:0005387	primary ovarian failure	down-regulated	RT-qPCR	"In POI, circDennd2a is decreased in patient serum and granulosa cells. Hypoxic MSC-derived exosomes deliver circDennd2a, which binds LDHA and increases its enzymatic activity (without markedly changing LDHA protein level), elevating NAD+/NADH and enhancing glycolysis. This promotes granulosa cell proliferation and reduces apoptosis, supporting a potential diagnostic/therapeutic role in POI."	0.8215
39695793	Stem cell research & therapy	2024	Hypoxic mesenchymal stem cell-derived exosomal circDennd2a regulates granulosa cell glycolysis by interacting with LDHA.	rno_circ_0002142	circDennd2a / HM-Exs-circDennd2a	rno_circ_Dennd2a	Dennd2a	Premature ovarian insufficiency / POI	MONDO:0005387	primary ovarian failure	down-regulated	RT-qPCR	"In POI, circDennd2a is decreased in patient serum and granulosa cells. Hypoxic MSC-derived exosomes deliver circDennd2a, which binds LDHA and increases its enzymatic activity (without markedly changing LDHA protein level), elevating NAD+/NADH and enhancing glycolysis. This promotes granulosa cell proliferation and reduces apoptosis, supporting a potential diagnostic/therapeutic role in POI."	0.8215
39697423	World journal of oncology	2024	Interferon Gamma Receptor 2 Collaborates With Circular RNA/MicroRNA to Modulate Programmed Cell Death-Ligand 1 Levels in Nasopharyngeal Carcinoma.	hsa_circ_0000054	circ_001377 / hsa_circ_001377	hsa_circ_MRPS15	MRPS15	nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; Microarray	"circ_001377 (MRPS15-derived; hsa_circ_001377/hsa_circ_0000054) is up-regulated in NPC cell lines and functions as an oncogenic ceRNA. It sponges miR-498-3p, relieving repression of IFNGR2 and consequently increasing PD-L1 via IFN-gamma pathway activation."	0.642
39698112	Frontiers in molecular biosciences	2024	CircMIB1 inhibits glioma development and progression through a competing endogenous RNA interaction network.	hsa_circ_0000835	circMIB1 / circRNA-mind bomb homolog 1	hsa_circ_MIB1	MIB1	glioma	MONDO:0021042	glioma	down-regulated	RT-qPCR; RNA-seq	"CircMIB1 (hsa_circ_0000835), derived from MIB1, is significantly down-regulated in glioma tissues and cell lines and is associated with tumor grade. Higher circMIB1 expression correlates with better survival and it shows diagnostic potential (high AUC). Mechanistically, it is proposed to act via a ceRNA network by binding hsa-miR-1290 and influencing downstream targets (ADD2, CTC1, SRCIN1, RORA, VPS4A, ULK2) linked to cell cycle/circadian rhythm/apoptotic necrosis programs."	0.6895
39698527	Health science reports	2024	Identification of Serum-Derived CricRNA Diagnostic Panel and Revealing Their Regulatory Mechanisms in HCV-HCC: A Cross-Sectional Study.	hsa_circ_0003288				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"Serum hsa_circ_0003288 is up-regulated in HCV-induced HCC (and also elevated in HCC vs controls) and shows diagnostic value by ROC analysis. The study also constructed a predicted circRNA_miRNA_mRNA network for mechanistic exploration, without experimental validation of specific miRNA targets."	0.459
39698527	Health science reports	2024	Identification of Serum-Derived CricRNA Diagnostic Panel and Revealing Their Regulatory Mechanisms in HCV-HCC: A Cross-Sectional Study.	hsa_circ_0067717	circ_RNF13 / cric_RNF13	hsa_circ_RNF13	RNF13	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"Serum circ-RNF13 (hsa_circ_0067717) is up-regulated in HCV-induced HCC and HCC compared with controls. In the HCV-induced HCC group, circ-RNF13 levels show a negative correlation with IL-6, and it is included in a bioinformatically predicted circRNA_miRNA_mRNA network and ROC-based diagnostic assessment."	0.459
39698527	Health science reports	2024	Identification of Serum-Derived CricRNA Diagnostic Panel and Revealing Their Regulatory Mechanisms in HCV-HCC: A Cross-Sectional Study.	hsa_circ_0004277				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"Serum hsa_circ_0004277 is up-regulated in HCV-induced HCC and in HCC compared with controls, and it is evaluated by ROC analysis with diagnostic potential reported for the HCV-HCC group. The study additionally built a predicted circRNA_miRNA_mRNA network for this circRNA, without experimental validation of specific interactors."	0.459
39698527	Health science reports	2024	Identification of Serum-Derived CricRNA Diagnostic Panel and Revealing Their Regulatory Mechanisms in HCV-HCC: A Cross-Sectional Study.	hsa_circ_0008574	circANRIL / circ_ANRIL	hsa_circ_ANRIL	ANRIL	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"Serum circANRIL (hsa_circ_0008574) is up-regulated in HCV-induced HCC and in HCC compared with controls, and it is proposed as part of a diagnostic panel. A circRNA_miRNA_mRNA network was constructed bioinformatically for potential regulatory mechanisms, without direct experimental validation of interactions."	0.459
39698527	Health science reports	2024	Identification of Serum-Derived CricRNA Diagnostic Panel and Revealing Their Regulatory Mechanisms in HCV-HCC: A Cross-Sectional Study.	hsa_circ_0048677	circUHRF1 / cricuHRF1	hsa_circ_UHRF1	UHRF1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"Serum circUHRF1 (hsa_circ_0048677) is up-regulated in HCV-induced HCC and in HCC compared with controls, and is proposed as part of a diagnostic biomarker panel. The paper provides bioinformatic circRNA_miRNA_mRNA network construction for mechanistic exploration, without specific interaction validation."	0.459
39698527	Health science reports	2024	Identification of Serum-Derived CricRNA Diagnostic Panel and Revealing Their Regulatory Mechanisms in HCV-HCC: A Cross-Sectional Study.		hsa_circ_103047			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"Serum hsa_circ_103047 is up-regulated in HCV-induced HCC and in HCC compared with controls, and is proposed as part of a diagnostic panel with ROC support. In the HCV-induced HCC group, hsa_circ_103047 expression is negatively correlated with NF-kappaB; mechanistic exploration is limited to bioinformatic circRNA_miRNA_mRNA network construction."	0.459
39698574	Translational andrology and urology	2024	Anti-cancer role of curcumin in prostate cancer cells via regulation of m6A-modified circ0030568-FMR1 signaling pathway.	hsa_circ_0030568	circ0030568 / circ_0030568	hsa_circ_ABCC4	ABCC4	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circ0030568 is up-regulated and m6A-modified in prostate cancer cells, where it promotes proliferation and migration. METTL3 installs m6A on circ0030568 and the reader YTHDF2 increases circ0030568 stability; circ0030568 in turn upregulates FMR1. Curcumin suppresses PCa cell proliferation/migration by inhibiting YTHDF2 and reducing METTL3/YTHDF2-driven circ0030568 stability and downstream FMR1."	0.7884
39702234	Biology direct	2024	Exosomes containing circSCP2 in colorectal cancer promote metastasis via sponging miR-92a-1-5p and interacting with PTBP1 to stabilize IGF2BP1.	hsa_circ_0006906	circSCP2	hsa_circ_SCP2	SCP2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circSCP2 (hsa_circ_0006906) is up-regulated in CRC tissues and circulating/serum exosomes and promotes proliferation, EMT, invasion and metastasis. It acts as a miR-92a-1-5p sponge to increase IGF2BP1 and also binds PTBP1 to inhibit PTBP1 ubiquitination, thereby stabilizing PTBP1 and enhancing IGF2BP1 mRNA stability. Exosomal circSCP2 additionally influences the tumor microenvironment (e.g., CAF activation and M2 macrophage polarization) and is proposed as a prognostic circulating biomarker."	0.8861
39702523	"Schizophrenia (Heidelberg, Germany)"	2024	The neurodevelopmental regulatory role and clinical value of hsa-circ-CORO1C-hsa-miR-708-3p-JARID2_+_LNPEP axis in early-onset schizophrenia.			hsa_circ_CORO1C	CORO1C	early-onset schizophrenia / EOS	MONDO:0019939	early-onset schizophrenia	down-regulated	RT-qPCR; RNA-seq	"In EOS, hsa-circ-CORO1C is downregulated and functions as a ceRNA by sponging hsa-miR-708-3p, thereby relieving repression of JARID2 and LNPEP. This multi-molecular axis shows diagnostic value (ROC) and is linked to neurodevelopment-related effects through downstream targets."	0.797
39702523	"Schizophrenia (Heidelberg, Germany)"	2024	The neurodevelopmental regulatory role and clinical value of hsa-circ-CORO1C-hsa-miR-708-3p-JARID2_+_LNPEP axis in early-onset schizophrenia.	hsa_circ_0001189	hsa-circ-0001189			early-onset schizophrenia / EOS	MONDO:0019939	early-onset schizophrenia	unknown	RT-qPCR; RNA-seq	"hsa-circ-0001189 can bind hsa-miR-708-3p (luciferase), but its knockdown did not change hsa-miR-708-3p, JARID2, or LNPEP levels, suggesting it is not a functional ceRNA regulator in the EOS axis established here."	0.7399
39705232	PloS one	2024	Circular RNA circ-CARD8 regulates alveolar macrophage pyroptosis through the miR-580-3p/CARD8 pathway in acute lung injury.	hsa_circ_0002749	circ-CARD8	hsa_circ_CARD8	CARD8	acute lung injury / ALI	MONDO:0015796	acute lung injury	down-regulated	RT-qPCR	"In sepsis-induced ALI (and an LPS-induced THP-1 macrophage model), circ-CARD8 is downregulated. circ-CARD8 acts as a sponge for miR-580-3p to preserve CARD8 expression, thereby suppressing caspase-1/GSDMD-mediated macrophage pyroptosis and reducing inflammatory mediator release."	0.7946
39707013	Inflammation	2025	CircIRAK3 Promotes Neutrophil Extracellular Trap Formation by Improving the Stability of ELANE mRNA in Sepsis.		circIRAK3	hsa_circ_IRAK3	IRAK3	sepsis	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR; RNA-seq	"circIRAK3 is up-regulated in peripheral blood neutrophils from sepsis patients and correlates with plasma NET levels. Functionally, it promotes NET formation by binding ELAVL1 and enhancing ELANE mRNA stability, increasing elastase expression."	0.8701
39713717	Journal of inflammation research	2024	Hsa_circRNA_100791 Modulates Trim13 Through Sponging miR-487b-5p to Facilitate Inflammation in Allergic Rhinitis.	hsa_circ_0004851	hsa_circRNA_100791 / hsa_circ_100791	hsa_circ_CAPRIN1	CAPRIN1	allergic rhinitis / AR	MONDO:0011786	allergic rhinitis	up-regulated	RT-qPCR; RNA-seq	"hsa_circRNA_100791 is up-regulated in PBMCs and nasal mucosa of allergic rhinitis patients and mainly localizes to the cytoplasm. It promotes AR-associated inflammation by sponging miR-487b-5p to increase TRIM13 expression, enhancing NF-kappaB activation and pro-inflammatory cytokine production; knockdown alleviates OVA-induced AR symptoms in mice."	0.8389
39719688	Journal of cellular and molecular medicine	2024	Differential Expression Spectrum of circRNA in Plasma Exosomes in Dilated Cardiomyopathy With Heart Failure.	hsa_circ_0047519				Dilated cardiomyopathy / DCM	MONDO:0005021	dilated cardiomyopathy	dysregulated	RT-qPCR	hsa_circ_0047519 is a plasma exosomal hub circRNA that is significantly dysregulated in DCM patients with CHF versus healthy controls and was validated by RT-qPCR in an external cohort.	0.2995
39719688	Journal of cellular and molecular medicine	2024	Differential Expression Spectrum of circRNA in Plasma Exosomes in Dilated Cardiomyopathy With Heart Failure.	hsa_circ_0063766				Dilated cardiomyopathy / DCM	MONDO:0005021	dilated cardiomyopathy	dysregulated	RT-qPCR	hsa_circ_0063766 is a plasma exosomal hub circRNA significantly dysregulated in DCM with CHF and validated by RT-qPCR in an external cohort.	0.2995
39719688	Journal of cellular and molecular medicine	2024	Differential Expression Spectrum of circRNA in Plasma Exosomes in Dilated Cardiomyopathy With Heart Failure.		"hsa_circ_76,771"			Dilated cardiomyopathy / DCM	MONDO:0005021	dilated cardiomyopathy	dysregulated	RT-qPCR	"hsa_circ_76,771 is a plasma exosomal hub circRNA significantly dysregulated in DCM with CHF and validated by RT-qPCR in an external cohort."	0.2995
39719688	Journal of cellular and molecular medicine	2024	Differential Expression Spectrum of circRNA in Plasma Exosomes in Dilated Cardiomyopathy With Heart Failure.	hsa_circ_0054400				Dilated cardiomyopathy / DCM	MONDO:0005021	dilated cardiomyopathy	dysregulated	RT-qPCR	hsa_circ_0054400 is a plasma exosomal hub circRNA significantly dysregulated in DCM with CHF and validated by RT-qPCR in an external cohort.	0.2995
39719688	Journal of cellular and molecular medicine	2024	Differential Expression Spectrum of circRNA in Plasma Exosomes in Dilated Cardiomyopathy With Heart Failure.	hsa_circ_0019699				Dilated cardiomyopathy / DCM	MONDO:0005021	dilated cardiomyopathy	dysregulated	RT-qPCR	hsa_circ_0019699 is a plasma exosomal hub circRNA significantly dysregulated in DCM with CHF and validated by RT-qPCR in an external cohort.	0.2995
39719688	Journal of cellular and molecular medicine	2024	Differential Expression Spectrum of circRNA in Plasma Exosomes in Dilated Cardiomyopathy With Heart Failure.	hsa_circ_0074153				Dilated cardiomyopathy / DCM	MONDO:0005021	dilated cardiomyopathy	dysregulated	RT-qPCR	hsa_circ_0074153 is a plasma exosomal hub circRNA significantly dysregulated in DCM with CHF and validated by RT-qPCR in an external cohort.	0.2995
39719688	Journal of cellular and molecular medicine	2024	Differential Expression Spectrum of circRNA in Plasma Exosomes in Dilated Cardiomyopathy With Heart Failure.	hsa_circ_0075837				Dilated cardiomyopathy / DCM	MONDO:0005021	dilated cardiomyopathy	dysregulated	RT-qPCR	hsa_circ_0075837 is a plasma exosomal hub circRNA significantly dysregulated in DCM with CHF and validated by RT-qPCR in an external cohort.	0.2995
39719688	Journal of cellular and molecular medicine	2024	Differential Expression Spectrum of circRNA in Plasma Exosomes in Dilated Cardiomyopathy With Heart Failure.	hsa_circ_0056066				Dilated cardiomyopathy / DCM	MONDO:0005021	dilated cardiomyopathy	dysregulated	RT-qPCR	hsa_circ_0056066 is a plasma exosomal hub circRNA significantly dysregulated in DCM with CHF and validated by RT-qPCR in an external cohort.	0.2995
39719688	Journal of cellular and molecular medicine	2024	Differential Expression Spectrum of circRNA in Plasma Exosomes in Dilated Cardiomyopathy With Heart Failure.	hsa_circ_0026806				Dilated cardiomyopathy / DCM	MONDO:0005021	dilated cardiomyopathy	dysregulated	RT-qPCR	hsa_circ_0026806 is a plasma exosomal hub circRNA significantly dysregulated in DCM with CHF and validated by RT-qPCR in an external cohort.	0.2995
39720459	Molecular and clinical oncology	2025	"hsa_circ_0001508 as a new gene that may promote breast cancer progression via the miR_505_3p/HMGB1, VGLL3 axis."	hsa_circ_0001508	circ_0001508			breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001508 is up-regulated in breast cancer tissues and highly expressed in HCC1937 cells. Silencing hsa_circ_0001508 suppresses proliferation, migration and invasion and increases apoptosis, and is associated with increased miR-505-3p and decreased HMGB1/VGLL3 expression, supporting a putative hsa_circ_0001508_miR-505-3p_HMGB1/VGLL3 regulatory axis."	0.5089
39723345	Degenerative neurological and neuromuscular disease	2024	Integrated Transcriptome Analysis Reveals Molecular Subtypes and ceRNA Networks in Multiple Sclerosis.	hsa_circ_0045537	circ_0045537			Multiple sclerosis / MS	MONDO:0005301	multiple sclerosis	dysregulated	RNA-seq	"In MS subtype C3, circ_0045537 is proposed to act as a ceRNA sponge for miR-196a-5p, thereby influencing the hub target gene TUBA1A. This axis may modulate microtubule dynamics in immune and neuronal cells and potentially worsen disease severity."	0.1768
39727990	Current issues in molecular biology	2024	"The Diagnostic Value of circFBXW7, circABCB10, and circ0103552 Levels in Breast Cancer."	hsa_circ_0001451	circFBXW7	hsa_circ_FBXW7	FBXW7	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	Serum circFBXW7 is significantly down-regulated in breast cancer patients versus healthy controls and correlates with BC diagnosis. It shows potential as a non-invasive diagnostic biomarker based on ROC analysis.	0.4187
39727990	Current issues in molecular biology	2024	"The Diagnostic Value of circFBXW7, circABCB10, and circ0103552 Levels in Breast Cancer."	hsa_circ_0008717	circABCB10	hsa_circ_ABCB10	ABCB10	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"Serum circABCB10 is significantly up-regulated in breast cancer patients versus healthy controls and correlates with BC diagnosis. It has diagnostic value in ROC analysis, supporting its use as a non-invasive biomarker."	0.4187
39727990	Current issues in molecular biology	2024	"The Diagnostic Value of circFBXW7, circABCB10, and circ0103552 Levels in Breast Cancer."	hsa_circ_0103552	circ0103552			breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	Serum circ0103552 is significantly down-regulated in breast cancer patients versus healthy controls and correlates with BC diagnosis. It shows the strongest diagnostic performance among the tested circRNAs by ROC analysis.	0.4187
39733742	Translational oncology	2025	circICMT upregulates and suppresses the malignant behavior of bladder cancer.	hsa_circ_0007427	circICMT / circ7427	hsa_circ_ICMT	ICMT	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; RNA-seq	"circICMT (hsa_circ_0007427; circ7427), derived from ICMT, is up-regulated in bladder cancer tissues and functions as a tumor suppressor by inhibiting proliferation, colony formation and migration in vitro and reducing xenograft tumor growth in vivo. Mechanistically, the study provides bioinformatic predictions that circICMT may be packaged in extracellular vesicles and interact with multiple miRNAs and RBPs, forming a complex regulatory network."	0.7081
39736524	BMC cardiovascular disorders	2024	Construction of AMPK-related circRNA network in mouse myocardial ischemia-reperfusion injury model.		novel_circ_043550			myocardial ischemia/reperfusion injury	MONDO:0005203	ischemia reperfusion injury	dysregulated	RT-qPCR; RNA-seq	"novel_circ_043550 was identified as an AMPK-related differentially expressed circRNA in a mouse MIRI model and was validated by RT-qPCR. The study constructed a predicted circRNA_miRNA_mRNA (ceRNA) network including this circRNA to speculate its potential involvement in processes such as mitophagy and energy metabolism in MIRI, but did not perform direct functional perturbation experiments."	0.4997
39736524	BMC cardiovascular disorders	2024	Construction of AMPK-related circRNA network in mouse myocardial ischemia-reperfusion injury model.		novel_circ_035243			myocardial ischemia/reperfusion injury	MONDO:0005203	ischemia reperfusion injury	dysregulated	RT-qPCR; RNA-seq	novel_circ_035243 was identified as an AMPK-related differentially expressed circRNA in a mouse MIRI model and was validated by RT-qPCR. It was included in a predicted circRNA_miRNA_mRNA (ceRNA) regulatory network and bioinformatics analyses linked it to functions including calcium channel activity; no direct functional intervention experiments were performed.	0.3684
39738128	Nature communications	2024	Fast and sensitive multivalent spatial pattern-recognition for circular RNA detection.		circular RNA SCMH1 / circSCMH1	mmu_circ_Scmh1	SCMH1	ischemic stroke / IS	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR; ISH	"circSCMH1 (from the SCMH1 gene) is significantly down-regulated in acute ischemic stroke and can be detected in AIS patient plasma and in mouse brain after stroke. The study primarily uses circSCMH1 as a model target to demonstrate a fast TDF sensor, and notes that circSCMH1 exerts functions via binding to RBPs such as MeCP2 and FTO."	0.6428
39744434	International journal of biological sciences	2025	CircMVP promotes METTL3 activation mediated CTNNB1 m6A modification in the inhibition of colorectal cancer in B7-H3 dependence antitumor immunity.	hsa_circ_0000688	circMVP / Alias_000014	hsa_circ_MVP	MVP	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Northern Blot; ISH; RNA-seq	"circMVP (hsa_circ_0000688) is up-regulated in colorectal cancer and promotes tumor growth, invasion and immune evasion. Mechanistically, circMVP binds and stabilizes METTL3 (mainly in the nucleus), enhances METTL3-mediated m6A modification on CTNNB1 mRNA to increase beta-catenin translation/nuclear activity, and induces CD276/B7-H3 expression to suppress anti-tumor T cell responses. Targeting circMVP enhances the efficacy of anti-B7-H3 immunotherapy in vivo."	0.8959
39744871	Aging cell	2025	circSIRT2/miR-542-3p/VASH1 axis regulates endothelial-to-mesenchymal transition (EndMT) in subretinal fibrosis in age-related macular degeneration models.	hsa_circ_0050951	circSIRT2 / m_circRNA_6228	hsa_circ_SIRT2	SIRT2	age_related macular degeneration / nAMD	MONDO:0005150	age-related macular degeneration	up-regulated	RT-qPCR; RNA-seq	"circSIRT2 is up-regulated in subretinal fibrosis models and suppresses EndMT, reducing fibrotic marker expression as well as endothelial proliferation and migration. It acts mainly as a cytoplasmic miRNA sponge for miR-542-3p, thereby increasing VASH1 expression and limiting SRF lesion development in vivo."	0.7201
39744871	Aging cell	2025	circSIRT2/miR-542-3p/VASH1 axis regulates endothelial-to-mesenchymal transition (EndMT) in subretinal fibrosis in age-related macular degeneration models.		circSIRT2 / m_circRNA_6228	mmu_circ_SIRT2	SIRT2	age_related macular degeneration / nAMD	MONDO:0005150	age-related macular degeneration	up-regulated	RT-qPCR; RNA-seq	"circSIRT2 is up-regulated in subretinal fibrosis models and suppresses EndMT, reducing fibrotic marker expression as well as endothelial proliferation and migration. It acts mainly as a cytoplasmic miRNA sponge for miR-542-3p, thereby increasing VASH1 expression and limiting SRF lesion development in vivo."	0.7201
39747873	Nature communications	2025	The protein circPETH-147aa regulates metabolic reprogramming in hepatocellular carcinoma cells to remodel immunosuppressive microenvironment.	hsa_circ_0049398	circPETH	hsa_circ_LDLR	LDLR	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circPETH (hsa_circ_0049398) is an EV-packaged circRNA mainly produced by TAMs and transferred to HCC cells, where it promotes glycolysis and metastatic phenotypes. It is overexpressed in HCC tissues and high expression correlates with worse clinicopathologic features and poor OS/RFS, serving as an independent prognostic indicator. circPETH also functions as the RNA template that can be m6A-dependently translated into circPETH-147aa in HCC cells."	0.8695
39747873	Nature communications	2025	The protein circPETH-147aa regulates metabolic reprogramming in hepatocellular carcinoma cells to remodel immunosuppressive microenvironment.		circPETH-147aa / circRNA-147aa	hsa_circ_LDLR	LDLR	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	Others	"circPETH-147aa is an m6A-driven translation product of circPETH that directly binds PKM2/ALDOA and boosts PKM2 kinase activity to promote ALDOA-S36 phosphorylation via its MEG pocket, enhancing glycolysis and metastatic traits in HCC cells. It also binds HuR to increase SLC43A2 mRNA stability, elevating methionine/leucine uptake by tumor cells and suppressing CD8+ T-cell cytotoxicity; norathyriol blocks this by targeting the MEG pocket and improves anti-PD1 efficacy."	0.7596
39748101	Scientific reports	2025	"Silencing circ_0043256 inhibited CoCl2-induced proliferation, migration, and aerobic glycolysis in gastric cancer cells."	hsa_circ_0043256	circ_0043256 / circular RNA 0043256			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"circ_0043256 is up-regulated in gastric cancer tissues and GC cell lines. Its knockdown suppresses CoCl2-induced proliferation, migration/invasion, and aerobic glycolysis while promoting apoptosis and G2/M arrest. Mechanistically, circ_0043256 binds miR-593-5p to regulate the miR-593-5p/RRM2 axis and downstream glycolysis-related proteins, and its silencing inhibits tumor growth in xenograft models."	0.7375
39748364	Molecular cancer	2025	circASAP1 induces renal clear cell carcinoma ferroptosis by binding to HNRNPC and thereby regulating GPX4.			hsa_circ_ASAP1	ASAP1	clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR; RNA-seq	"circASAP1 is up-regulated in ccRCC and promotes malignant phenotypes (proliferation, migration/invasion, metastasis). Mechanistically, it binds cytoplasmic HNRNPC and modulates its ubiquitin-proteasome_related protein stability, thereby reducing GPX4 mRNA stability/protein levels and promoting ferroptosis; clinically, high circASAP1 associates with metastasis and poor survival."	0.8833
39759366	Heliyon	2024	Plasma-based transcriptomic non-coding signature for predicting relapse in pediatric acute lymphoblastic leukemia.	hsa_circ_0022620				pediatric acute lymphoblastic leukemia / ALL	MONDO:0000870	childhood acute lymphoblastic leukemia	up-regulated	RT-qPCR; Microarray	"hsa_circ_0022620 is up-regulated in pediatric ALL with the highest levels observed in relapsed patients, and it is used as part of a plasma/bone marrow non-coding RNA panel to predict relapse risk at initial diagnosis."	0.5534
39759366	Heliyon	2024	Plasma-based transcriptomic non-coding signature for predicting relapse in pediatric acute lymphoblastic leukemia.	hsa_circ_0061990				pediatric acute lymphoblastic leukemia / ALL	MONDO:0000870 	childhood acute lymphoblastic leukemia	up-regulated	RT-qPCR; Microarray	"hsa_circ_0061990 shows increased expression across healthy controls, initial diagnosis, and relapsed pediatric ALL, and contributes to a combined non-coding RNA panel used to predict relapse risk."	0.5534
39759366	Heliyon	2024	Plasma-based transcriptomic non-coding signature for predicting relapse in pediatric acute lymphoblastic leukemia.	hsa_circ_0039036				pediatric acute lymphoblastic leukemia / ALL	MONDO:0000870	childhood acute lymphoblastic leukemia	up-regulated	RT-qPCR; Microarray	hsa_circ_0039036 is elevated in pediatric ALL and shows the highest expression in relapsed patients; it is included in a three-circRNA panel (and combined six-ncRNA panel) that predicts relapse risk using plasma and matched bone marrow samples.	0.5534
39759393	"Clinical, cosmetic and investigational dermatology"	2024	EIF4A3 Enhances the Proliferation and Cell Cycle Progression of Keloid Fibroblasts by Inducing the hsa_circ_0002198 Expression.	hsa_circ_0002198	circ_0002198	hsa_circ_PDE7B	PDE7B	keloid	MONDO:0005348	keloid	up-regulated	RT-qPCR	"hsa_circ_0002198 (circ_0002198) is up-regulated in keloid tissues and keloid fibroblasts. Its knockdown suppresses KF proliferation, migration and invasion, induces G1 arrest, and increases apoptosis, and it functionally associates with EIF4A3 and cell-cycle regulators (Cyclin D1/E1, CDK4, P21)."	0.7801
39759896	International journal of general medicine	2024	Serum Hsa_circ_0023919 is a Predictive Biomarker of Chemoresistance in CRC Treatment.	hsa_circ_0023919		hsa_circ_PICALM	PICALM	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"Serum/plasma hsa_circ_0023919 is up-regulated in CRC, especially in chemoresistant patients, and correlates with TNM stage. Higher hsa_circ_0023919 is associated with worse OS/PFS and shows diagnostic value for chemoresistance (ROC AUC ~0.90), suggesting it promotes chemoresistance and may serve as a therapeutic target."	0.4992
39762891	Molecular cancer	2025	Exosomal circ_0006896 promotes AML progression via interaction with HDAC1 and restriction of antitumor immunity.	hsa_circ_0006896	circ_0006896 / circ_006896	hsa_circ_KIAA1429	KIAA1429	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; RNA-seq; Microarray	"circ_0006896 (hsa_circ_0006896), derived from KIAA1429, is up-regulated in AML cells and bone-marrow exosomes and is associated with relapse and poor prognosis. It promotes AML progression and chemoresistance by binding HDAC1 to reduce histone H3 acetylation, repressing arachidonic-acid metabolism/ferroptosis-related transcription and inhibiting lipid peroxidation-driven ferroptosis. Exosomal circ_0006896 also binds HDAC1 in CD8+ T cells to repress LEF1 and cytotoxic molecules (e.g., IFN-gamma, Granzyme B), contributing to immune evasion and reduced efficacy of adoptive T-cell therapy."	0.8941
39766913	Genes	2024	New Axes of Interaction in Circ_0079593/miR-516b-5p Network in Melanoma Metastasis Cell Lines.	hsa_circ_0079593	circ_0079593	hsa_circ_IGF2BP3	IGF2BP3	melanoma	MONDO:0005105	melanoma	up-regulated	RT-qPCR	"circ_0079593 is up-regulated in melanoma metastatic cell lines and promotes metastatic melanoma cell migration. Mechanistically, it sponges miR-516b-5p, reducing miR-516b-5p activity and thereby supporting higher MCAM and CHAF1B expression."	0.6263
39774281	Hepatology communications	2025	Hsa_circ_0109623 regulates the progression of autoimmune liver disease through Hsa_miR_146b-3p/Sortilin 1-mediated activation of CD4+ T cells.	hsa_circ_0109623	Circ_0109623 / Circ-0109623	hsa_circ_FCGBP	FCGBP	autoimmune hepatitis / AIH	MONDO:0016264	autoimmune hepatitis	up-regulated	RT-qPCR	"hsa_circ_0109623 is up-regulated in AIH liver tissue/PBMCs and promotes inflammatory responses by enhancing CD4+ T-cell activation and Th1 polarization. Mechanistically, it functions as a ceRNA sponge for hsa-miR-146b-3p, relieving repression of SORT1 and contributing to AIH progression."	0.7823
39779892	Scientific reports	2025	hsa_circ_0008305 facilitates the malignant progression of hepatocellular carcinoma by regulating AKR1C3 expression and sponging miR-379-5p.	hsa_circ_0008305	circPTK2 / circ_0008305	hsa_circ_PTK2	PTK2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"hsa_circ_0008305 (circPTK2) is up-regulated in HCC and mainly localized in the cytoplasm. It promotes HCC cell proliferation, migration, invasion, and xenograft tumor growth by sponging miR-379-5p to increase AKR1C3 expression (circPTK2/miR-379-5p/AKR1C3 ceRNA axis)."	0.8781
39785769	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2025	Primary Cilia Formation Mediated by Hsa_Circ_0005185/OTUB1/RAB8A Complex Inhibits Prostate Cancer Progression by Suppressing Hedgehog Signaling Pathway.	hsa_circ_0005185	circ_0005185 / circ_0 005185	hsa_circ_PRKD1	PRKD1	prostate cancer / PCa	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; ISH; RNA-seq; Microarray	"circ_0005185 (hsa_circ_0005185), derived from PRKD1, is down-regulated in prostate cancer/CRPC and enzalutamide-resistant contexts. It binds OTUB1 and RAB8A as a scaffold to promote OTUB1-mediated K48 deubiquitination and stabilization of RAB8A, enhancing primary cilia formation, increasing GLI3R, inhibiting Hedgehog signaling and AR activity, and suppressing tumor progression and drug resistance."	0.8785
39796015	International journal of molecular sciences	2024	CircTEC Inhibits the Follicular Atresia in Buffalo (Bubalus bubalis) via Targeting miR-144-5p/FZD3 Signaling Axis.		circTEC / circ-002750	bbu_circ_TEC	TEC	follicular atresia	MONDO:0005558	ovarian disorder	down-regulated	RT-qPCR; RNA-seq	"circTEC is down-regulated in atretic follicles and functions as a cytoplasmic ceRNA that sponges miR-144-5p, thereby relieving repression of FZD3. Through the miR-144-5p/FZD3 axis, circTEC promotes granulosa cell proliferation and steroid hormone synthesis and inhibits apoptosis, ultimately suppressing follicular atresia in buffalo."	0.8067
39799463	Journal of cellular and molecular medicine	2025	Renal Tubular Epithelial Cell-Derived hsa_circ_0008925 From Urine Is Related to Chronic Renal Fibrosis.	hsa_circ_0008925		hsa_circ_SEC63	SEC63	renal fibrosis / RF	MONDO:0000494	renal fibrosis	up-regulated	RT-qPCR	"hsa_circ_0008925 is up-regulated in urine-derived renal tubular epithelial cells from CKD patients with more severe renal fibrosis and is induced by TGF-beta1 in HK-2 cells. Functionally, it promotes fibrogenesis by interacting with and upregulating SRSF6; silencing hsa_circ_0008925 reduces SRSF6 and fibrosis markers (collagen I, alpha-SMA), supporting the hsa_circ_0008925/SRSF6 pathway as a potential therapeutic target."	0.6898
39799463	Journal of cellular and molecular medicine	2025	Renal Tubular Epithelial Cell-Derived hsa_circ_0008925 From Urine Is Related to Chronic Renal Fibrosis.	mmu_circ_0002215				renal fibrosis / RF	MONDO:0000494	renal fibrosis	unknown	RT-qPCR	"In the UUO mouse model, knockdown of mmu_circ_0002215 via AAV-shRNA alleviates renal fibrosis and decreases fibrotic markers and SRSF6 in kidney tissue, supporting a profibrotic role of this mouse homolog circRNA in vivo."	0.421
39802311	Oncology letters	2025	CircENTPD7 affects the immune escape of non_small cell lung cancer cells by modulating the IGF2BP2/PD_L1 axis.	hsa_circ_0019421	circENTPD7	hsa_circ_ENTPD7	ENTPD7	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"CircENTPD7 is up-regulated in NSCLC (H1299 vs BEAS-2B). Its knockdown suppresses NSCLC malignant phenotypes (proliferation, migration, invasion) and it promotes immune escape by modulating the IGF2BP2/PD-L1 axis."	0.421
39802932	Analytical cellular pathology (Amsterdam)	2025	circ-ZEB1 Enhances NSCLC Metastasis and Proliferation by Modulating the miR-491-5p/EIF5A Axis.	hsa_circ_0018082	circ-ZEB1	hsa_circ_ZEB1	ZEB1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; ISH	"circ-ZEB1 is up-regulated in NSCLC tissues and cell lines and mainly localizes to the cytoplasm. Functionally, circ-ZEB1 promotes NSCLC proliferation, migration/invasion, tumor growth, and lung metastasis by sponging miR-491-5p to increase EIF5A expression (circ-ZEB1/miR-491-5p/EIF5A axis)."	0.6829
39810134	BMC cancer	2025	CircCCT2/miR-146a-5p/IRAK1 axis promotes the development of head and neck squamous cell carcinoma.	hsa_circ_0000418	CircCCT2	hsa_circ_CCT2	CCT2	head and neck squamous cell carcinoma / HNSCC	MONDO:0010150	head and neck squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circCCT2 (hsa_circ_0000418) is up-regulated in HNSCC tissues and cell lines and mainly localizes to the cytoplasm. It promotes HNSCC proliferation, migration/invasion and xenograft growth by sponging miR-146a-5p to upregulate IRAK1 and drive EMT, and high circCCT2 expression is associated with advanced stage and poor overall survival."	0.8836
39810713	The Kaohsiung journal of medical sciences	2025	hnRNPA2B1 drives colorectal cancer progression via the circCDYL/EIF4A3/PHF8 axis.		circCDYL	hsa_circ_CDYL	CDYL	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"In CRC cell lines, circCDYL is down-regulated and functions as a tumor suppressor by inhibiting proliferation, migration, and invasion. Mechanistically, hnRNPA2B1-dependent m6A modification decreases circCDYL, weakening circCDYL binding to EIF4A3 and thereby increasing PHF8 expression to promote CRC progression."	0.7363
39814850	Oncogene	2025	m6A-modified circSTX6 as a key regulator of cervical cancer malignancy via SPI1 and IL6/JAK2/STAT3 pathways.	hsa_circ_0007905	circSTX6	hsa_circ_STX6	STX6	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; RNA-seq	"circSTX6 (hsa_circ_0007905) is up-regulated in cervical cancer and predicts worse overall survival. It promotes proliferation, invasion and migration by binding and stabilizing SPI1, which increases IL6 transcription and activates the IL6/JAK2/STAT3 pathway. METTL3-dependent m6A modification (read by YTHDC1) stabilizes circSTX6, forming a METTL3/circSTX6/SPI1 positive feedback loop."	0.8849
39820362	Communications biology	2025	Hypoxia-induced circPLOD2a/b promotes the aggressiveness of glioblastoma by suppressing XIRP1 through binding to HuR.	hsa_circ_0141963	circPLOD2a	hsa_circ_PLOD2	PLOD2	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; RNA-seq	"circPLOD2a is up-regulated by hypoxia/HIF1alpha in glioblastoma and promotes invasion/migration and xenograft progression. It binds the RBP HuR and competitively disrupts HuR binding to XIRP1 mRNA, reducing XIRP1 stability/expression and enhancing EMT-associated aggressiveness."	0.8615
39820362	Communications biology	2025	Hypoxia-induced circPLOD2a/b promotes the aggressiveness of glioblastoma by suppressing XIRP1 through binding to HuR.	hsa_circ_0067682	circPLOD2b	hsa_circ_PLOD2	PLOD2	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; RNA-seq	"circPLOD2b (hsa_circ_0067682) is a hypoxia/HIF1alpha-induced circRNA in glioblastoma, mainly localized in the cytoplasm. It promotes invasion/migration and xenograft progression by binding HuR and competitively reducing HuR association with XIRP1 mRNA, leading to XIRP1 downregulation and enhanced EMT/aggressiveness."	0.8682
39821691	International journal of oncology	2025	circ_0004662 contributes to colorectal cancer progression by interacting with hnRNPM.	hsa_circ_0004662	circ_0004662	hsa_circ_SOD2	SOD2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0004662 is up-regulated in colorectal cancer tissues and cell lines. Functionally, it promotes CRC malignant behavior, especially migration, and its knockdown suppresses tumor growth in a xenograft model. Mechanistically, circ_0004662 acts as a non-coding circRNA that binds the RBP hnRNPM, and hnRNPM depletion reduces circ_0004662 levels, supporting a circ_0004662_hnRNPM regulatory interaction in CRC progression."	0.8695
39822377	Open life sciences	2024	Role of circRMRP and circRPL27 in chronic obstructive pulmonary disease.	hsa_circ_0001853	circRMRP / circRNA0001853	hsa_circ_RMRP	RMRP	chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR	"Serum circRMRP is up-regulated in COPD and increases with disease severity. It correlates positively with smoking history and WBC and negatively with FEV1/FVC, and shows diagnostic potential for COPD (AUC 0.8646)."	0.4187
39822377	Open life sciences	2024	Role of circRMRP and circRPL27 in chronic obstructive pulmonary disease.	hsa_circ_0043926	circRPL27 / circ_0043926	hsa_circ_RPL27	RPL27	chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR	"Serum circRPL27 is up-regulated in COPD and increases with disease severity. It correlates positively with smoking history and WBC and negatively with FEV1/FVC and FEV1, and shows strong diagnostic performance for COPD (AUC 0.9552), outperforming circRMRP in this cohort."	0.4187
39823477	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2025	CircDNA2-Educated YTHDF2 Phase Separation Promotes PM2.5-Induced Malignant Transformation Through the Blunting of GADD45A Expression.		CircDNA2	hsa_circ_DNA2	DNA2	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circDNA2 is upregulated after chronic PM2.5 exposure and in lung cancer tissues, and it promotes malignant transformation phenotypes. Mechanistically, circDNA2 binds the LC domain of YTHDF2 to enhance YTHDF2 LLPS and thereby blunts GADD45A expression via an m6A-dependent, YTHDF2-mediated post-transcriptional mechanism. High circDNA2 expression is associated with worse overall survival, supporting its prognostic value in lung cancer."	0.9
39823497	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2025	Bimodal In Situ Analyzer for Circular RNA in Extracellular Vesicles Combined with Machine Learning for Accurate Gastric Cancer Detection.		Circ-URI1 / circURI1	hsa_circ_URI1	URI1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"EV-associated circ-URI1 is up-regulated in gastric cancer plasma samples and is used as one of four EV-circRNA biomarkers measured by the BEISA platform. Together with the other markers and machine learning, it supports noninvasive classification of healthy donors vs gastric cancer patients and helps early-stage diagnosis."	0.5121
39823497	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2025	Bimodal In Situ Analyzer for Circular RNA in Extracellular Vesicles Combined with Machine Learning for Accurate Gastric Cancer Detection.		circ_YME1L1	hsa_circ_YME1L1	YME1L1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	Others	EV-circYME1L1 is up-regulated in gastric cancer plasma EVs and is used as one component of a four-circRNA BEISA biomarker panel combined with machine learning for gastric cancer detection and staging.	0.4484
39823497	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2025	Bimodal In Situ Analyzer for Circular RNA in Extracellular Vesicles Combined with Machine Learning for Accurate Gastric Cancer Detection.		EV-circCWF19L1	hsa_circ_CWF19L1	CWF19L1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	Others	EV-circCWF19L1 is up-regulated in gastric cancer plasma EVs and is included in a four-circRNA BEISA biomarker panel combined with machine learning for gastric cancer detection and staging.	0.4484
39823497	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2025	Bimodal In Situ Analyzer for Circular RNA in Extracellular Vesicles Combined with Machine Learning for Accurate Gastric Cancer Detection.		EV-circOGA	hsa_circ_OGA	OGA	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	Others	EV-circOGA is up-regulated in gastric cancer plasma EVs and is included in a four-circRNA BEISA biomarker panel combined with machine learning for gastric cancer detection and staging.	0.4484
39825374	Cancer cell international	2025	Senescence-related circRNA circHIF-1alpha is associated with pancreatic cancer progression.	hsa_circ_0007976	circHIF-1alpha	hsa_circ_HIF-1alpha	HIF-1alpha	pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; ISH; RNA-seq; Microarray	"circHIF-1alpha is up-regulated in pancreatic cancer tissues and cell lines and is associated with poor overall survival. Functionally, it inhibits cellular senescence and promotes proliferation, migration/invasion and metastasis. Mechanistically, it increases HIF-1alpha via cytoplasmic sponging of miR-375 and via nuclear binding to HUR to enhance HIF-1alpha mRNA stability."	0.8944
39831223	Journal of thoracic disease	2024	Circular RNA SPECC1 promoted tumorigenesis and osimertinib resistance in lung adenocarcinoma via a circular RNA-microRNA network.		SPECC1 circular RNA / circSPECC1	hsa_circ_SPECC1	SPECC1	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circSPECC1 is up-regulated in LUAD/NSCLC tumors and promotes malignant phenotypes (proliferation, migration, invasion, adhesion). circSPECC1 knockdown increases osimertinib-induced apoptosis and restores TKI sensitivity, and a ceRNA network suggests it sponges miR-598-3p/miR-33a-3p/miR-497-5p/miR-369-3p to affect downstream mRNAs (e.g., TUBB1, BCHE, BNIP3, LHFPL6, SLC39A4)."	0.6117
39836545	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2025	A Novel 167-Amino Acid Protein Encoded by CircPCSK6 Inhibits Intrahepatic Cholangiocarcinoma Progression via IKBalpha Ubiquitination.	hsa_circ_0037100	circPCSK6	hsa_circ_PCSK6	PCSK6	intrahepatic cholangiocarcinoma / ICC	MONDO:0003210	intrahepatic cholangiocarcinoma	down-regulated	RT-qPCR	"circPCSK6 (hsa_circ_0037100), derived from the PCSK6 gene, is down-regulated in intrahepatic cholangiocarcinoma and acts as a tumor suppressor. It exerts major effects via its encoded peptide circPCSK6-167aa, which inhibits NF-kappaB signaling by stabilizing IkappaBalpha through reduced ubiquitination, and its expression is negatively regulated by the RBP EIF4A3."	0.8671
39838328	BMC molecular and cell biology	2025	BRAF regulates circPSD3/miR-526b/RAP2A axis to hinder papillary thyroid carcinoma progression.	hsa_circ_0002111	circPSD3 / Circular RNA PSD3	hsa_circ_PSD3	PSD3	papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circPSD3 is up-regulated in papillary thyroid carcinoma and promotes malignant phenotypes (proliferation, migration/invasion, and tumor growth) while inhibiting apoptosis. Mechanistically, it functions as a ceRNA by sponging miR-526b to increase RAP2A expression, and BRAF overexpression suppresses this circPSD3/miR-526b/RAP2A axis."	0.8355
39843498	Scientific reports	2025	Identification of prognostic biomarkers of sepsis and construction of ceRNA regulatory networks.	hsa_circ_0026658	HSA_CIRC_0026658			sepsis	MONDO:0005229	bacterial infectious disease with sepsis	unknown	RNA-seq	"HSA_CIRC_0026658 was identified from blood circRNA-seq as part of a predicted sepsis prognosis-related ceRNA network. It is hypothesized to sponge miRNAs and thereby indirectly regulate the core genes GSPT1 and NPRL3, linking it to immune-response processes and sepsis outcome."	0.1768
39843498	Scientific reports	2025	Identification of prognostic biomarkers of sepsis and construction of ceRNA regulatory networks.	hsa_circ_0026654	HSA_CIRC_0026654			sepsis	MONDO:0005229	bacterial infectious disease with sepsis	unknown	RNA-seq	"HSA_CIRC_0026654 was identified from blood circRNA-seq as part of a predicted sepsis prognosis-related ceRNA network. It is hypothesized to sponge miRNAs and thereby indirectly regulate the core genes GSPT1 and NPRL3, linking it to immune-response processes and sepsis outcome."	0.1768
39843498	Scientific reports	2025	Identification of prognostic biomarkers of sepsis and construction of ceRNA regulatory networks.	hsa_circ_0026660	HSA_CIRC_0026660			sepsis	MONDO:0005229	bacterial infectious disease with sepsis	unknown	RNA-seq	"HSA_CIRC_0026660 was identified from blood circRNA-seq as part of a predicted sepsis prognosis-related ceRNA network. It is hypothesized to sponge miRNAs and thereby indirectly regulate the core genes GSPT1 and NPRL3, linking it to immune-response processes and sepsis outcome."	0.1768
39843498	Scientific reports	2025	Identification of prognostic biomarkers of sepsis and construction of ceRNA regulatory networks.	hsa_circ_0026657	HSA_CIRC_0026657			sepsis	MONDO:0005229	bacterial infectious disease with sepsis	unknown	RNA-seq	"HSA_CIRC_0026657 was identified from blood circRNA-seq as part of a predicted sepsis prognosis-related ceRNA network. It is hypothesized to sponge miRNAs and thereby indirectly regulate the core genes GSPT1 and NPRL3, linking it to immune-response processes and sepsis outcome."	0.1768
39844192	Journal of translational medicine	2025	A novel peptide encoded by circSRCAP confers resistance to enzalutamide by inhibiting the ubiquitin-dependent degradation of AR-V7 in castration-resistant prostate cancer.	hsa_circ_0006127	circSRCAP / circular RNA SRCAP	hsa_circ_SRCAP	SRCAP	castration-resistant prostate cancer / CRPC	MONDO:0850353	castration-resistant prostate carcinoma	up-regulated	RT-qPCR; RNA-seq	"circSRCAP is up-regulated in ENZ-resistant CRPC cells and promotes enzalutamide resistance. It functions mainly by encoding a 75-aa peptide (circSRCAP-75aa) that binds HSP70, disrupts HSP70_STUB1-dependent ubiquitination, stabilizes AR/AR-V7, and thereby increases AR-V7 protein levels."	0.8595
39856701	Molecular cancer	2025	Circular RNA circBNC2 inhibits tumorigenesis by modulating ferroptosis and acts as a nanotherapeutic target in prostate cancer.	hsa_circ_0008732	circBNC2	hsa_circ_BNC2	BNC2	prostate cancer / PCa	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR	"circBNC2 (hsa_circ_0008732), derived from BNC2, is downregulated in prostate cancer tissues and cell lines. It suppresses tumor cell proliferation, migration and invasion and promotes ferroptosis by sponging miR-4298 to release ACSL6, and its low expression correlates with more advanced clinicopathological features."	0.8685
39856764	Journal of experimental & clinical cancer research : CR	2025	GC-derived exosomal circMAN1A2 promotes cancer progression and suppresses T-cell antitumour immunity by inhibiting FBXW11-mediated SFPQ degradation.	hsa_circ_0000118	circMAN1A2	hsa_circ_MAN1A2	MAN1A2	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"circMAN1A2 (hsa_circ_0000118) is upregulated and enriched in GC-derived exosomes and is associated with poor prognosis and diagnostic potential in plasma exosomes. Functionally, exosomal circMAN1A2 promotes GC proliferation/migration and metastasis and suppresses T-cell antitumour effector functions. Mechanistically, it is packaged into exosomes via hnRNPA2B1 and binds SFPQ to block FBXW11-mediated K48-linked ubiquitination and proteasomal degradation of SFPQ, stabilizing SFPQ and inhibiting TCR signalling in T cells."	0.8977
39858034	Cancers	2025	EIF4A3-Mediated circ_0008126 Inhibits the Progression and Metastasis of Gastric Cancer by Modulating the APC/beta-Catenin Pathway.	hsa_circ_0008126	circ_0008126	hsa_circ_STX12	STX12	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; ISH; Microarray	"circ_0008126 is down-regulated in gastric cancer and acts as a tumor suppressor. It inhibits proliferation, EMT, and metastasis by sponging miR-502-5p to increase APC and suppress Wnt/beta-catenin signaling, and by binding EIF4A3 to enhance APC mRNA stability. Low circ_0008126 expression is associated with lymphatic metastasis, advanced TNM stage, and poorer survival."	0.8892
39866227	Oncology research	2025	Circular RNA circAGAP1 promotes sunitinib sensitivity in renal cell carcinoma via sponging multiple PDGFR-targeted miRNAs.	hsa_circ_0058792	circAGAP1	hsa_circ_AGAP1	AGAP1	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR	"In ccRCC, circAGAP1 is higher in sunitinib-sensitive cells than resistant cells and enhances sunitinib sensitivity. It mainly functions as a cytoplasmic ceRNA that sponges miR-149-5p, miR-455-5p, and miR-15a-5p, thereby regulating PDGFR and suppressing proliferation/colony formation/migration while increasing apoptosis under sunitinib treatment."	0.657
39866238	Oncology research	2025	Circ-PAN3 facilitates hepatocellular carcinoma growth via sponging miR-153 and upregulating cyclin D1.		circ-PAN3	hsa_circ_PAN3	PAN3	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circ-PAN3 is up-regulated in HCC tissues/cell lines and its high level predicts poorer overall survival. Functionally, circ-PAN3 promotes HCC growth by acting as a ceRNA that sponges miR-153, thereby relieving repression of cyclin D1 (CCND1) and enhancing cell-cycle progression and proliferation."	0.7699
39866239	Oncology research	2025	CircRNA circ_0015278 induces ferroptosis in lung adenocarcinoma through the miR-1228/P53 axis.	hsa_circ_0015278	circ_0015278 / circ_100395	hsa_circ_KLHL20	KLHL20	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; Microarray	"circ_0015278 is down-regulated in LUAD tissues/cell lines and acts as a tumor suppressor. It promotes ferroptosis and inhibits proliferation/migration/invasion by sponging miR-1228 to upregulate P53 and suppress SLC7A11, reducing LUAD growth in a xenograft model."	0.7401
39866243	Molecular therapy. Oncology	2025	circ-1584 selectively promotes the antitumor activity of the oncolytic virus M1 on pancreatic cancer.	hsa_circ_0031584	circ-1584 / circ1584			pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	down-regulated	RT-qPCR; ISH; RNA-seq	"circ-1584 is a key circRNA associated with M1 virus responsiveness in pancreatic cancer cells. It enhances M1 virus replication and M1-mediated viability inhibition in vitro and improves antitumor efficacy in a CFPAC-1 xenograft model. Mechanistically, it binds/sponges and downregulates miR-578, affecting downstream genes including CLCN6, ZNF117, HABP4, and RARB, and it may serve as a biomarker for M1 virus response (negative correlation with ZAP)."	0.8357
39867824	Cytotechnology	2025	Expression profiling of circular RNAs in sepsis-induced acute gastrointestinal injury: insights into potential biomarkers and mechanisms.	hsa_circ_0008381				sepsis-induced acute gastrointestinal injury / AGI	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RNA-seq	"hsa_circ_0008381 is up-regulated in peripheral blood of sepsis-induced AGI patients and shows a stepwise increase with AGI severity, suggesting potential use as a biomarker for disease progression. Its mechanistic role is only computationally inferred via circRNA-miRNA interaction network analysis (miRNA sponge potential) without experimental validation."	0.1768
39867824	Cytotechnology	2025	Expression profiling of circular RNAs in sepsis-induced acute gastrointestinal injury: insights into potential biomarkers and mechanisms.	hsa_circ_0071375				sepsis-induced acute gastrointestinal injury / AGI	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RNA-seq	"hsa_circ_0071375 is up-regulated in peripheral blood of sepsis-induced AGI patients and increases stepwise with AGI severity, indicating potential value as a biomarker of progression. Network analysis suggests it may act through circRNA-miRNA interactions to regulate downstream mRNA expression, but no experimental validation was performed."	0.1768
39867824	Cytotechnology	2025	Expression profiling of circular RNAs in sepsis-induced acute gastrointestinal injury: insights into potential biomarkers and mechanisms.		novel_circ_0007538			sepsis-induced acute gastrointestinal injury / AGI	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RNA-seq	"novel_circ_0007538 shows progressively higher expression from mild (AGI I_II) to severe (AGI III_IV) sepsis-induced AGI in peripheral blood, suggesting potential value as a biomarker of AGI severity. No specific interaction partners or mechanisms were reported for this circRNA in the provided text."	0.1768
39867824	Cytotechnology	2025	Expression profiling of circular RNAs in sepsis-induced acute gastrointestinal injury: insights into potential biomarkers and mechanisms.		novel_circ_0002987			sepsis-induced acute gastrointestinal injury / AGI	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RNA-seq	"novel_circ_0002987 shows progressively higher expression from mild (AGI I_II) to severe (AGI III_IV) sepsis-induced AGI in peripheral blood, suggesting potential value as a biomarker of AGI severity. No specific interaction partners or mechanisms were reported for this circRNA in the provided text."	0.1768
39868042	iScience	2025	Mechanism of hsa_circ_0069443 promoting early pregnancy loss through ALKBH5/FN1 axis in trophoblast cells.	hsa_circ_0069443	circ0069443			pregnancy loss	MONDO:0006774	habitual spontaneous abortion	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0069443 is down-regulated in early pregnancy loss. It promotes trophoblast proliferation/migration/invasion and, when packaged into trophoblast-derived exosomes, enhances endometrial stromal cell migration/invasion and promotes EMT of endometrial epithelial cells. Mechanistically it binds ALKBH5 and modulates m6A-dependent FN1 mRNA stability/expression, forming a hsa_circ_0069443_ALKBH5_FN1 axis linked to early pregnancy loss."	0.8739
39868374	Frontiers in oncology	2024	EIF4A3-induced circ_0022382 promotes breast cancer cell progression through the let-7a-5p/PI3K/AKT/mTOR signaling pathway and SLC7A11 axis.	hsa_circ_0022382	circ_0022382			breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circ_0022382 is up-regulated in breast cancer tissues and cell lines and promotes proliferation and migration. Mechanistically, it sponges let-7a-5p to activate PI3K/AKT/mTOR signaling and increase SLC7A11, while its knockdown induces features consistent with disulfidptosis and suppresses tumor growth in a xenograft model; EIF4A3 promotes circ_0022382 biogenesis."	0.7761
39868921	Neuro-oncology	2025	CircPRKD3-loaded exosomes concomitantly elicit tumor growth inhibition and glioblastoma microenvironment remodeling via inhibiting STAT3 signaling.	hsa_circ_0000992	circPRKD3 / GDE-circPRKD3	hsa_circ_PRKD3	PRKD3	glioblastoma / GBM	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR; RNA-seq	"circPRKD3 is reduced in glioblastoma-related samples (notably GSC-derived exosomes and patient plasma exosomes) and higher levels associate with better patient prognosis. Functionally, exosomal circPRKD3 suppresses glioma growth and invasion and remodels the immune microenvironment by promoting macrophage M1-like reprogramming and CD8+ T-cell infiltration. Mechanistically, circPRKD3 binds the RBP HNRNPC in an m6A-dependent manner to destabilize IL6ST mRNA and inhibit IL6ST/JAK/STAT3 signaling, contributing to antitumor immunity (including CXCL10 induction)."	0.8847
39869636	PLoS pathogens	2025	Staphylococcus aureus blocks host autophagy through circSyk/miR-5106/Sik3 axis to promote progression of bone infection.		circSyk	mmu_circ_Syk	Syk	S. aureus-induced bone infection	MONDO:0005545	staphylococcus aureus infection	up-regulated	RT-qPCR	"In S. aureus-induced bone infection, circSyk is up-regulated in infected osteoclasts, patient serum, and in a mouse model. circSyk acts as a ceRNA by sponging miR-5106 to increase Sik3, which is associated with Akt/mTOR signaling to inhibit autophagy, enhancing intracellular bacterial survival and promoting bone destruction; circSyk knockdown improves autophagy and bone repair and reduces bacterial load."	0.7471
39871338	Molecular cancer	2025	CircTTC13 promotes sorafenib resistance in hepatocellular carcinoma through the inhibition of ferroptosis by targeting the miR-513a-5p/SLC7A11 axis.	hsa_circ_0000195	circTTC13 / cicTTC13	hsa_circ_TTC13	TTC13	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circTTC13 (hsa_circ_0000195), derived from TTC13, is up-regulated in HCC and mainly localized in the cytoplasm. It promotes HCC malignant behaviors and sorafenib resistance by inhibiting ferroptosis via sponging miR-513a-5p, thereby upregulating SLC7A11."	0.8567
39879906	"Clinics (Sao Paulo, Brazil)"	2025	Hsa_circ_0000105 promotes nasopharyngeal carcinoma malignancy by miR-541-3p/S100A11 axis.	hsa_circ_0000105		hsa_circ_CD53	CD53	Nasopharyngeal Carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; Northern Blot	"hsa_circ_0000105 is up-regulated in nasopharyngeal carcinoma tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation, invasion, migration and EMT while inhibiting apoptosis by sponging miR-541-3p to upregulate S100A11, and its knockdown suppresses xenograft tumor growth."	0.854
39881153	Communications biology	2025	Hsa_circ_0001304 promotes vascular neointimal hyperplasia accompanied by autophagy activation.	hsa_circ_0001304	circ-1304	hsa_circ_RBM5	RBM5	vascular neointimal hyperplasia	MONDO:0005385	vascular disorder	up-regulated	RT-qPCR; Microarray	"In PDGF-BB-stimulated human aortic smooth muscle cells, hsa_circ_0001304 (circ-1304) is up-regulated and promotes VSMC autophagy. It sponges miR-636 to increase YTHDF2, which then enhances m6A-dependent degradation of mTOR mRNA, and circ-1304 overexpression aggravates neointimal hyperplasia in a carotid ligation mouse model."	0.8015
39881399	Journal of orthopaedic surgery and research	2025	Unveiling new therapeutic horizons in rheumatoid arthritis: an In-depth exploration of circular RNAs derived from plasma exosomes.	hsa_circ_0002715				rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"In plasma exosomes from MTX-IR RA patients receiving TNFi, hsa-circ0002715 is higher in ACR20 responders than non-responders, supporting its use as a predictive biomarker for TNFi treatment outcome."	0.459
39881399	Journal of orthopaedic surgery and research	2025	Unveiling new therapeutic horizons in rheumatoid arthritis: an In-depth exploration of circular RNAs derived from plasma exosomes.	hsa_circ_0001946	circRNA_0001946			rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	down-regulated	RT-qPCR	"In plasma exosomes from MTX-IR RA patients receiving TNFi, hsa-circ0001946 is lower in ACR20 responders than non-responders, supporting its use as a predictive biomarker for TNFi treatment outcome."	0.459
39884255	"Clinics (Sao Paulo, Brazil)"	2025	circLOC375190 promotes autophagy through modulation of the mTORC1/TFEB axis in acute ischemic stroke-induced neurological injury.	hsa_circ_0007270	circLOC375190	hsa_circ_LOC375190	LOC375190	ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR	"circLOC375190 is up-regulated in AIS models and promotes neuronal autophagy, apoptosis, and inflammatory injury. It functions as a miR-93-5p sponge to increase MKNK2 and engage the mTORC1/TFEB axis, thereby aggravating neurological damage in tMCAO/OGD-R settings."	0.7735
39885395	Cellular & molecular biology letters	2025	"CircUCK2(2,3) promotes cancer progression and enhances synergistic cytotoxicity of lenvatinib with EGFR inhibitors via activating CNIH4-TGFalpha-EGFR signaling."	hsa_circ_0006758	"circUCK2(2,3) / circRNA.1_165890204-165891322"	hsa_circ_UCK2	UCK2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circUCK2(2,3) is up-regulated in HCC and promotes proliferation, migration/invasion, and metastasis. It acts as a ceRNA by sponging miR-149-5p to relieve repression of CNIH4, increasing TGFalpha secretion and activating EGFR with downstream AKT/ERK signaling. High circUCK2(2,3) predicts poorer recurrence-free survival and may indicate better response to combined lenvatinib plus EGFR inhibition."	0.8996
39889249	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2025	NGR-Modified CAF-Derived exos Targeting Tumor Vasculature to Induce Ferroptosis and Overcome Chemoresistance in Osteosarcoma.	hsa_circ_0004872	circ_0004872 / circ_4872			osteosarcoma / OS	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; RNA-seq	"In doxorubicin-resistant osteosarcoma cells, hsa_circ_0004872 is down-regulated, and restoring it (or its encoded 109-aa peptide) increases chemosensitivity. Mechanistically, the circRNA-encoded peptide promotes autophagy-dependent ferroptosis (with increased ferroptosis markers and LC3 changes), thereby reversing chemoresistance; targeted delivery is achieved via NGR-modified CAF-derived exosomes."	0.6966
39891203	Molecular cancer	2025	CircRNF13 enhances IGF2BP1 phase separation-mediated ITGB1 mRNA stabilization in an m6A-dependent manner to promote oral cancer cisplatin chemoresistance.	hsa_circ_0006801	circRNF13	hsa_circ_RNF13	RNF13	oral cancer	MONDO:0005515	oral cavity cancer	up-regulated	RT-qPCR; Microarray	"circRNF13 is up-regulated in oral cancer tissues/cell lines and promotes proliferation, migration, tumor growth and cisplatin chemoresistance. Mechanistically, it binds the m6A reader RBP IGF2BP1 to inhibit ubiquitination-mediated degradation and enhance IGF2BP1 phase separation, which increases m6A-dependent stabilization of ITGB1 mRNA."	0.8585
39891781	Clinical and experimental medicine	2025	CircRNA circACTN4 Promotes the Progression of Epithelial-Mesenchymal Transition in Hepatocellular Carcinoma by Targeting the miR-424-5p/NCAPG/Wnt Axis.	hsa_circ_0050900	circACTN4	hsa_circ_ACTN4	ACTN4	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circACTN4 (hsa_circ_0050900) is up-regulated in HCC tissues/cell lines and promotes HCC proliferation, migration/invasion, EMT, and tumor growth while inhibiting apoptosis. It functions as a ceRNA sponging miR-424-5p to upregulate NCAPG and activate Wnt/beta-catenin signaling, and higher circACTN4 is associated with poor prognosis."	0.7375
39892393	American journal of human genetics	2025	Inter-chromosomal insertions at Xq27.1 associated with retinal dystrophy induce dysregulation of LINC00632 and CDR1as/ciRS-7.		CDR1as / ciRS-7	hsa_circ_LINC00632	LINC00632	retinal dystrophy	MONDO:0019118	inherited retinal dystrophy	down-regulated	RT-qPCR; RNA-seq	"In X-linked inherited retinal dystrophy families with Xq27.1 inter-chromosomal insertions, CDR1as/ciRS-7 shows tissue-specific dysregulation and is down-regulated in retinal organoids and RPE. As a miR-7 sponge, reduced CDR1as/ciRS-7 is associated with dysregulation of validated miR-7 target transcripts, supporting a circRNA/miRNA/mRNA mechanism contributing to disease."	0.5922
39895095	International journal of immunopathology and pharmacology	2025	Aurora-A promotes lenvatinib resistance experimentally through hsa-circ-0058046/miR-424-5p/FGFR1 axis in hepatocellular carcinoma.	hsa_circ_0058046		hsa_circ_BARD1	BARD1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa-circ-0058046 (from BARD1) is upregulated in HCC cell lines and promotes lenvatinib resistance as well as proliferation/migration and pro-angiogenic activity. It mainly localizes to the cytoplasm and functions as a ceRNA sponge of miR-424-5p to increase FGFR1 expression, forming the hsa-circ-0058046/miR-424-5p/FGFR1 axis."	0.8491
39899667	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2025	CircMETTL6 Suppresses Ovarian Cancer Cell Growth and Metastasis Through Inhibition of GDF15 Transcription by Disrupting the NONO-POLR2A Complex.		circMETTL6	hsa_circ_METTL6	METTL6	ovarian cancer / OC	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR; ISH; RNA-seq	"circMETTL6 is down-regulated in ovarian cancer and functions as a tumor suppressor. It binds NONO and disrupts the NONO_POLR2A complex, reducing POLR2A-dependent transcription of GDF15, thereby inhibiting proliferation and metastasis and associating low expression with poor prognosis."	0.8722
39901821	Cardiovascular research	2025	Circular RNAs increase during vascular cell differentiation and are biomarkers for vascular disease.		circCOL4A1	hsa_circ_COL4A1	COL4A1	atherosclerosis / AS	MONDO:0005311	atherosclerosis	down-regulated	RNA-seq	circCOL4A1 is part of a four-circRNA signature that is decreased in atherosclerotic arterial tissue versus healthy tissue and can discriminate atherosclerotic from healthy aortic tissue (AUC ~0.79). The study treats it primarily as an operational biomarker rather than demonstrating a mechanistic role in disease.	0.348
39901821	Cardiovascular research	2025	Circular RNAs increase during vascular cell differentiation and are biomarkers for vascular disease.		circCOL4A2	hsa_circ_COL4A2	COL4A2	atherosclerosis / AS	MONDO:0005311	atherosclerosis	down-regulated	RNA-seq	circCOL4A2 is decreased in atherosclerotic arterial tissue and contributes to a four-circRNA signature that classifies atherosclerotic vs healthy aortic tissue (AUC ~0.79). No mechanistic ceRNA/protein pathway was established for this circRNA in the study.	0.348
39901821	Cardiovascular research	2025	Circular RNAs increase during vascular cell differentiation and are biomarkers for vascular disease.		circHSPG2	hsa_circ_HSPG2	HSPG2	atherosclerosis / AS	MONDO:0005311	atherosclerosis	down-regulated	RNA-seq	"HSPG2-derived circRNAs are decreased in atherosclerotic disease and can serve as biomarkers: together with YPEL2 circRNAs they classify atherosclerosis vs non-atherosclerosis using PBMC RNA-seq (AUC ~0.73), and they are also part of a four-circRNA arterial tissue signature (AUC ~0.79). The study does not define a specific miRNA/protein mechanism for circHSPG2 in disease."	0.348
39901821	Cardiovascular research	2025	Circular RNAs increase during vascular cell differentiation and are biomarkers for vascular disease.		circYPEL2	hsa_circ_YPEL2	YPEL2	atherosclerosis / AS	MONDO:0005311	atherosclerosis	down-regulated	RNA-seq	"circYPEL2 is down-regulated in atherosclerotic state compared with healthy controls and is part of a PBMC RNA-seq biomarker signature (with HSPG2-derived circRNAs) that detects atherosclerosis (AUC ~0.73). It is also lower in ruptured vs elective AAA tissue. MYC inhibition modulates circYPEL2 levels, but circYPEL2 knockdown showed no obvious vascular cell phenotype in the reported tests."	0.5534
39901821	Cardiovascular research	2025	Circular RNAs increase during vascular cell differentiation and are biomarkers for vascular disease.		circCDYL	hsa_circ_CDYL	CDYL	abdominal aortic aneurysm / AAA	MONDO:0005350	abdominal aortic aneurysm	down-regulated	RT-qPCR	"circCDYL is reduced in more severe AAA (ruptured vs elective) based on qRT-PCR in human aneurysm biopsies, suggesting potential utility as a marker of AAA disease severity. The study does not provide a specific molecular mechanism for circCDYL in AAA."	0.2995
39902300	Frontiers in genetics	2024	Comprehensive analysis of the circRNA expression profile and circRNA-miRNA-mRNA network in pelvic organ prolapse.	hsa_circ_0067962				pelvic organ prolapse / POP	MONDO:0000082	pelvic organ prolapse	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0067962 is significantly down-regulated in peripheral blood from women with POP. The study proposes a ceRNA network in which hsa_circ_0067962 may regulate multiple mRNAs (e.g., COL10A1, LACC1, RBM44, AVEN, JAKMIP1, SGCB, ARL17B, CD40) via shared miRNAs and relates the network to collagen catabolic processes and POP pathogenesis; it also shows diagnostic potential by ROC analysis."	0.6556
39902300	Frontiers in genetics	2024	Comprehensive analysis of the circRNA expression profile and circRNA-miRNA-mRNA network in pelvic organ prolapse.	hsa_circ_0057051				pelvic organ prolapse / POP	MONDO:0000082	pelvic organ prolapse	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0057051 is significantly down-regulated in peripheral blood from women with POP. The study builds a ceRNA network linking hsa_circ_0057051 to PDE3A via predicted miRNAs and associates the validated circRNAs with collagen catabolic processes; ROC analysis suggests potential diagnostic utility in POP.	0.6556
39903274	Human genetics	2025	Global dysregulation of circular RNAs in frontal cortex and whole blood from DM1 and DM2.		hsa_CPNE1_0001	hsa_circ_CPNE1	CPNE1	myotonic dystrophy	MONDO:0016107	myotonic dystrophy	unknown	RNA-seq	"hsa_CPNE1_0001 is reported as an example circRNA whose back-splice junction uses cryptic splice sites located in the last coding exons, illustrating non-canonical splice-site usage contributing to circRNA biogenesis in DM1/DM2 tissues."	0.385
39903274	Human genetics	2025	Global dysregulation of circular RNAs in frontal cortex and whole blood from DM1 and DM2.		hsa_ZNF250_0004	hsa_circ_ZNF250	ZNF250	myotonic dystrophy	MONDO:0016107	myotonic dystrophy	unknown	RNA-seq	"hsa_ZNF250_0004 is used as an example of a circRNA whose back-splicing involves cryptic splice sites located in the 3¡ä-UTR, supporting the study¡¯s conclusion that cryptic donor/acceptor sites contribute to circRNA biogenesis in DM1/DM2 tissues."	0.385
39903274	Human genetics	2025	Global dysregulation of circular RNAs in frontal cortex and whole blood from DM1 and DM2.		hsa-ROBO2_0044	hsa_circ_ROBO2	ROBO2	myotonic dystrophy	MONDO:0016107	myotonic dystrophy	unknown	RNA-seq	"hsa-ROBO2_0044 is presented as an example of a purely intronic circRNA generated using unannotated (cryptic) intronic splice sites, highlighting cryptic splice-site usage in circRNA formation in DM1/DM2 tissues."	0.385
39903274	Human genetics	2025	Global dysregulation of circular RNAs in frontal cortex and whole blood from DM1 and DM2.		hsa-RASGRF2_0029	hsa_circ_RASGRF2	RASGRF2	myotonic dystrophy	MONDO:0016107	myotonic dystrophy	unknown	RNA-seq	"hsa-RASGRF2_0029 is described as an example of an exonic-intronic circRNA associated with unannotated intronic splice sites, supporting the study¡¯s observation that cryptic splice sites contribute to generating intron-containing circRNAs, particularly in blood, in DM1/DM2."	0.385
39903274	Human genetics	2025	Global dysregulation of circular RNAs in frontal cortex and whole blood from DM1 and DM2.		hsa-RC3H1_0001	hsa_circ_RC3H1	RC3H1	myotonic dystrophy	MONDO:0016107	myotonic dystrophy	up-regulated	RNA-seq	"In DM1 frontal cortex, hsa-RC3H1_0001 is upregulated and its flanking introns show enriched CUGBP1 binding motifs, suggesting regulation of its circularization by an RNA-binding protein (CUGBP1)."	0.385
39903274	Human genetics	2025	Global dysregulation of circular RNAs in frontal cortex and whole blood from DM1 and DM2.		hsa-DCLK2_0001	hsa_circ_DCLK2	DCLK2	myotonic dystrophy	MONDO:0016107	myotonic dystrophy	up-regulated	RNA-seq	"In DM1 cortex, hsa-DCLK2_0001 is an upregulated single-exon circRNA whose flanking introns show enriched CUGBP1 binding motifs, implying an RBP-associated influence on its circularization."	0.385
39905475	European journal of medical research	2025	Circular RNA encoded by PPARG in the peripheral blood and a lipopolysaccharide-induced cardiomyocyte inflammation model is identified as a marker of fulminant myocarditis.	hsa_circ_0064338	circ_PPARG	hsa_circ_PPARG	PPARG	fulminant myocarditis / FM	MONDO:0002815	acute myocarditis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0064338 (circ_PPARG), derived from PPARG, is up-regulated in peripheral blood of fulminant myocarditis patients and in an LPS-induced AC16 cardiomyocyte inflammation model. Its peripheral blood level shows diagnostic potential to distinguish FM patients from healthy controls based on ROC analysis."	0.5963
39905501	Journal of cardiothoracic surgery	2025	CircHIPK2 recruits SRSF1 to increase TXNIP mRNA stability and promotes autophagy-dependent ferroptosis and apoptosis in myocardial ischemia-reperfusion injury.	hsa_circ_0001756	CircHIPK2	hsa_circ_HIPK2	HIPK2	myocardial ischemia/reperfusion injury	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR	"circHIPK2 is up-regulated in H/R-treated human cardiomyocytes and in I/R mouse heart tissue. It promotes oxidative stress, inflammation, autophagy-dependent ferroptosis and apoptosis by recruiting SRSF1 to enhance TXNIP transcriptional recruitment and stabilize TXNIP mRNA, and circHIPK2 knockdown alleviates MIRI phenotypes in vitro and in vivo."	0.7014
39912944	Journal of cancer research and clinical oncology	2025	CircWDR78 inhibits the development of colorectal cancer by regulating the miR-653-3p/RGS4 axis.	hsa_circ_0006677	circWDR78 / circ_0006677	hsa_circ_WDR78	WDR78	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"circWDR78 is down-regulated in colorectal cancer and functions as a tumor suppressor by inhibiting proliferation and motility/EMT-related migration. Mechanistically, it acts as a ceRNA that sponges miR-653-3p to relieve repression of RGS4, forming a circWDR78/miR-653-3p/RGS4 regulatory axis."	0.8138
39920301	Scientific reports	2025	Mitigating effects of Jiawei Chaihu Shugan decoction on necroptosis and inflammation of hippocampal neurons in epileptic mice.		circRNA-Csnk1g3 / Circ_Csnk1g3	mmu_circ_Csnk1g3	Csnk1g3	epilepsy	MONDO:0005027	epilepsy	up-regulated	RT-qPCR; RNA-seq	"In pilocarpine-induced epileptic mice and HT22 epilepsy model, Circ_Csnk1g3 is up-regulated and has translation potential, encoding the peptide Csnk1g3-85aa. JWCHSGD or Circ_Csnk1g3 knockdown reduces Circ_Csnk1g3-related necroptosis/inflammation signaling (RIP1/RIP3/MLKL, TNF-alpha, IL-1beta, IL-6), alleviating neuronal injury and epileptic discharges."	0.6117
39921520	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2025	CircSATB1 Promotes Colorectal Cancer Liver Metastasis through Facilitating FKBP8 Degradation via RNF25-Mediated Ubiquitination.	hsa_circ_0064557	circSATB1	hsa_circ_SATB1	SATB1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circSATB1 (hsa_circ_0064557) is up-regulated in CRC, especially in cases with liver metastasis, and high expression predicts worse OS/PFS. It promotes CRC migration/invasion and liver metastasis by scaffolding RNF25 and FKBP8 to enhance RNF25-mediated K48 ubiquitination and proteasomal degradation of FKBP8, thereby activating mTOR signaling. circSATB1 is also detectable in plasma exosomes and has diagnostic value for CRLM."	0.887
39927144	Heliyon	2025	High-fat diet triggers transcriptomic changes in the olfactory bulb.		circApp	mmu_circ_APP	APP	obesity	MONDO:0011122	obesity disorder	down-regulated	RT-qPCR; RNA-seq	"In HFD-fed (obese) mice, circApp is down-regulated in the olfactory bulb and its expression positively correlates with its host gene App. The study reports transcriptomic association but does not establish a direct functional mechanism for circApp in HFD-related olfactory dysfunction."	0.4997
39927144	Heliyon	2025	High-fat diet triggers transcriptomic changes in the olfactory bulb.		circTrpc6	mmu_circ_TRPC6	TRPC6	obesity	MONDO:0011122	obesity disorder	up-regulated	RT-qPCR; RNA-seq	"In HFD-fed (obese) mice, circTrpc6 is up-regulated in the olfactory bulb and positively correlates with its host gene TRPC6. The study does not define a circTrpc6-specific downstream mechanism, but notes TRPC6¡¯s known links to neurite outgrowth/BDNF-related signaling."	0.4997
39930385	BMC genomics	2025	Genome-wide characterization of circular RNAs in three rat models of pulmonary hypertension reveals distinct pathological patterns.		rno-Inpp4a-0010 / rno-lnpp4a-0010	rno_circ_Inpp4a	Inpp4a	pulmonary hypertension / PH	MONDO:0005149	pulmonary hypertension	up-regulated	RT-qPCR; RNA-seq	"rno-Inpp4a-0010 is up-regulated in pulmonary arteries across PH rat models and is included in a validated circRNA-miRNA-mRNA axis where it is inversely associated with rno-miR-676 and positively associated with DOCK5, consistent with a ceRNA regulatory relationship in PH."	0.6675
39930385	BMC genomics	2025	Genome-wide characterization of circular RNAs in three rat models of pulmonary hypertension reveals distinct pathological patterns.		rno-Ntrk3_0005 / rno-Ntrk3-0005	rno_circ_Ntrk3	Ntrk3	pulmonary hypertension / PH	MONDO:0005149	pulmonary hypertension	down-regulated	RT-qPCR; RNA-seq	"rno-Ntrk3_0005 is down-regulated in PH rat pulmonary arteries and is part of two qRT-PCR-validated circRNA-miRNA-mRNA axes (with rno-miR-93-5p/SOBP and rno-miR-20a-5p/PTPRD/PPARGC1B), consistent with a ceRNA regulatory role. It is also noted as a DEcircRNA involved in the calcium signaling pathway in this study."	0.62
39930385	BMC genomics	2025	Genome-wide characterization of circular RNAs in three rat models of pulmonary hypertension reveals distinct pathological patterns.		rno-Med13l_0003	rno_circ_Med13l	Med13l	pulmonary hypertension / PH	MONDO:0005149	pulmonary hypertension	up-regulated	RT-qPCR; RNA-seq	rno-Med13l_0003 is significantly up-regulated in pulmonary arteries across three PH rat models and was experimentally validated by qRT-PCR; the study further confirmed its back-splice junction sequence.	0.4844
39930385	BMC genomics	2025	Genome-wide characterization of circular RNAs in three rat models of pulmonary hypertension reveals distinct pathological patterns.		rno-Atp1b3_0002	rno_circ_Atp1b3	Atp1b3	pulmonary hypertension / PH	MONDO:0005149	pulmonary hypertension	up-regulated	RT-qPCR; RNA-seq	rno-Atp1b3_0002 is significantly up-regulated in pulmonary arteries across three PH rat models and was validated by qRT-PCR; its back-splice junction was confirmed by sequencing in this study.	0.4844
39930385	BMC genomics	2025	Genome-wide characterization of circular RNAs in three rat models of pulmonary hypertension reveals distinct pathological patterns.		rno-Ankh_0001	rno_circ_Ankh	Ankh	pulmonary hypertension / PH	MONDO:0005149	pulmonary hypertension	up-regulated	RT-qPCR; RNA-seq	rno-Ankh_0001 is significantly up-regulated in pulmonary arteries across three PH rat models and was validated by qRT-PCR; its back-splice junction sequence was confirmed in this study.	0.4844
39930385	BMC genomics	2025	Genome-wide characterization of circular RNAs in three rat models of pulmonary hypertension reveals distinct pathological patterns.		rno-Ltbp1_0003	rno_circ_Ltbp1	Ltbp1	pulmonary hypertension / PH	MONDO:0005149	pulmonary hypertension	up-regulated	RT-qPCR; RNA-seq	rno-Ltbp1_0003 is significantly up-regulated in pulmonary arteries across three PH rat models and was validated by qRT-PCR; its back-splice junction sequence was confirmed in this study.	0.4844
39931528	International journal of nanomedicine	2025	"CircPRMT5, a Potential Salivary Biomarker, Facilitates the Progression of Head and Neck Squamous Cell Carcinoma via the IGF2BP3-SERPINE1 Pathway."		circPRMT5	hsa_circ_PRMT5	PRMT5	Head and neck squamous cell carcinoma / HNSCC	MONDO:0010150	head and neck squamous cell carcinoma	up-regulated	RT-qPCR	"circPRMT5 is up-regulated in HNSCC tissues and salivary exosomes and promotes HNSCC proliferation, migration/invasion, and cervical lymph node metastasis. It functions by binding and stabilizing IGF2BP3 protein, which increases SERPINE1 mRNA stability and SERPINE1 expression, and shows strong diagnostic value in salivary exosomes."	0.8585
39937418	Molecular neurobiology	2025	miR-758-3p Interferes with Neuronal Apoptosis in Cerebral Ischemia-Reperfusion by Inhibiting ILK.		circRNA (0000964) / Novel_circ_0000964			cerebral ischemia-reperfusion injury	MONDO:0005203	ischemia reperfusion injury	down-regulated	RT-qPCR; RNA-seq	"In rat CIRI (MCAO and OGD models), circRNA (0000964) is downregulated. It acts as a ceRNA sponge for miR-758-3p to relieve repression of ILK, thereby reducing Caspase-3-associated neuronal apoptosis and supporting neuronal viability, with links to AKT signaling."	0.6737
39948068	Cell death & disease	2025	CircFUNDC1 interacts with CDK9 to promote mitophagy in nucleus pulposus cells under oxidative stress and ameliorates intervertebral disc degeneration.	hsa_circ_0007290	circFUNDC1	hsa_circ_FUNDC1	FUNDC1	intervertebral disc degeneration / IDD	MONDO:0011385	intervertebral disk degenerative disorder	down-regulated	RT-qPCR; ISH	"circFUNDC1 is down-regulated in end-stage IVDD NPCs and predominantly nuclear. It binds CDK9 and recruits it to the FUNDC1 promoter to enhance FUNDC1 transcription/protein, promoting mitophagy, reducing ROS and senescence, and maintaining ECM anabolic factor expression, thereby delaying IVDD progression under oxidative stress."	0.8516
39951875	"Clinics (Sao Paulo, Brazil)"	2025	Circular RNA pappalysin-1 enhances glycolysis via microRNA-656-3p targeting G-protein subunit gamma-5 to promote colon cancer progression.	hsa_circ_0088233	circ-PAPPA / Circular RNA pappalysin-1	hsa_circ_PAPPA	PAPPA	colon cancer	MONDO:0021063	malignant colon neoplasm	up-regulated	RT-qPCR	"circ-PAPPA (hsa_circ_0088233) is up-regulated in colon cancer and promotes malignant behaviors and aerobic glycolysis. Mechanistically, it sponges miR-656_3p to relieve repression of GNG5 (miR-656_3p/GNG5 axis), and higher circ-PAPPA is associated with worse survival."	0.713
39953602	Alzheimer's research & therapy	2025	Circular RNA APP contributes to Alzheimer's disease pathogenesis by modulating microglial polarization via miR-1906/CLIC1 axis.		circAPP	mmu_circ_APP	APP	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR; Microarray	circAPP (derived from APP) is upregulated in the hippocampus of APP/PS1 mice and in Abeta-treated microglia. It localizes mainly in the cytoplasm and promotes AD-associated microglial M1/M2 polarization imbalance by binding miR-1906 and thereby increasing CLIC1 expression/channel activity; circAPP knockdown alleviates AD pathology and improves cognition in vivo.	0.7385
39961942	Clinical and experimental medicine	2025	Identification of CircRNAs that promote cancer and their potential contribution to hepatocellular carcinoma (HCC) pathogenesis.	hsa_circ_0003528	hsa_circRNA_103948	hsa_circ_SEC24A	SEC24A	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	Microarray	This circRNA was identified as upregulated in HCC microarray datasets and predicted to participate in a ceRNA network by competitively binding hsa-miR-370-3p. No downstream mRNA or functional phenotype was specifically assigned to this circRNA in the final hub-gene-centered axes.	0.1768
39961942	Clinical and experimental medicine	2025	Identification of CircRNAs that promote cancer and their potential contribution to hepatocellular carcinoma (HCC) pathogenesis.	hsa_circ_0001806	hsa_circRNA_104640	hsa_circ_CSPP1	CSPP1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	Microarray	This circRNA was identified as upregulated in HCC microarrays and predicted to bind several downregulated miRNAs (including hsa-miR-370-3p and hsa-miR-375) within a computationally constructed ceRNA framework. No specific downstream mRNA/hub-gene axis was assigned for this circRNA in the final network description.	0.1768
39961942	Clinical and experimental medicine	2025	Identification of CircRNAs that promote cancer and their potential contribution to hepatocellular carcinoma (HCC) pathogenesis.	hsa_circ_0032698	hsa_circRNA_101408	hsa_circ_TTLL5	TTLL5	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	Microarray	"hsa_circRNA_101408 is upregulated in HCC and forms multiple predicted ceRNA axes, including miR-136-5p/E2F1, miR-145-5p/H2AFX, and miR-383-5p/TOP2A. Through these axes it is implicated in promoting HCC progression, with downstream hub genes enriched in cell-cycle and angiogenesis-related processes."	0.1768
39961942	Clinical and experimental medicine	2025	Identification of CircRNAs that promote cancer and their potential contribution to hepatocellular carcinoma (HCC) pathogenesis.	hsa_circ_0043001	hsa_circRNA_102034	hsa_circ_RHOT1	RHOT1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	Microarray	hsa_circRNA_102034 is upregulated in HCC microarrays and was predicted to bind the downregulated miRNA hsa-miR-326 in the constructed circRNA_miRNA network. The study did not specify a downstream target mRNA or hub-gene axis for this circRNA.	0.1768
39961942	Clinical and experimental medicine	2025	Identification of CircRNAs that promote cancer and their potential contribution to hepatocellular carcinoma (HCC) pathogenesis.	hsa_circ_0001338	hsa_circRNA_001416	hsa_circ_RAB43	RAB43	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	Microarray	hsa_circRNA_001416 is an upregulated HCC-associated circRNA predicted to sponge hsa-miR-370-3p and hsa-miR-326 as part of the computational DUcircRNA_DDmiRNA network. The study did not detail its downstream mRNA targets or specific functional effects.	0.1768
39961942	Clinical and experimental medicine	2025	Identification of CircRNAs that promote cancer and their potential contribution to hepatocellular carcinoma (HCC) pathogenesis.	hsa_circ_0003892	hsa_circRNA_102451	hsa_circ_LDLR	LDLR	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	Microarray	"hsa_circRNA_102451 is upregulated in HCC and predicted to interact with hsa-miR-326 in the computational circRNA_miRNA network. The paper did not link this circRNA to specific downstream mRNA targets, pathways, or clinical outcomes."	0.1768
39961942	Clinical and experimental medicine	2025	Identification of CircRNAs that promote cancer and their potential contribution to hepatocellular carcinoma (HCC) pathogenesis.	hsa_circ_0003945	hsa_circRNA_104760	hsa_circ_UBAP2	UBAP2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	Microarray	hsa_circRNA_104760 is upregulated in HCC and was placed in the final ceRNA network as the upstream circRNA of the miR-758-3p/RAD51 axis. It is therefore implicated in promoting HCC progression through ceRNA-mediated upregulation of the hub gene RAD51.	0.1768
39961942	Clinical and experimental medicine	2025	Identification of CircRNAs that promote cancer and their potential contribution to hepatocellular carcinoma (HCC) pathogenesis.	hsa_circ_0027477	hsa_circRNA_101094	hsa_circ_NUP107	NUP107	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	Microarray	hsa_circRNA_101094 is upregulated in HCC and included in the final ceRNA network as an upstream circRNA in the miR-136-5p/E2F1 and miR-145-5p/H2AFX axes. It is thereby implicated in promoting HCC progression through ceRNA-mediated upregulation of hub genes.	0.1768
39961942	Clinical and experimental medicine	2025	Identification of CircRNAs that promote cancer and their potential contribution to hepatocellular carcinoma (HCC) pathogenesis.	hsa_circ_0008274	hsa_circRNA_101287	hsa_circ_UGGT2	UGGT2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	Microarray	hsa_circRNA_101287 is upregulated in HCC and predicted to bind hsa-miR-377-3p within the computational circRNA_miRNA network. The study did not provide specific downstream mRNA targets or functional/clinical validation for this circRNA.	0.1768
39961942	Clinical and experimental medicine	2025	Identification of CircRNAs that promote cancer and their potential contribution to hepatocellular carcinoma (HCC) pathogenesis.	hsa_circ_0001955	hsa_circRNA_101555	hsa_circ_CSNK1G1	CSNK1G1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	Microarray	hsa_circRNA_101555 is upregulated in HCC and included in the final ceRNA network as part of the miR-145-5p/H2AFX axis (together with other circRNAs). It is indirectly implicated as a cancer-promoting factor through ceRNA-mediated regulation of a hub gene.	0.1768
39961942	Clinical and experimental medicine	2025	Identification of CircRNAs that promote cancer and their potential contribution to hepatocellular carcinoma (HCC) pathogenesis.	hsa_circ_0009912	hsa_circRNA_100053	hsa_circ_MFN2	MFN2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	Microarray	"hsa_circRNA_100053 is upregulated in HCC and included in the final ceRNA network, particularly within the miR-145-5p/H2AFX axis. It is indirectly implicated as a cancer-promoting circRNA through computational ceRNA regulation of a hub gene."	0.1768
39961942	Clinical and experimental medicine	2025	Identification of CircRNAs that promote cancer and their potential contribution to hepatocellular carcinoma (HCC) pathogenesis.	hsa_circ_0001900	hsa_circRNA_000996	hsa_circ_CAMSAP1	CAMSAP1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	Microarray	hsa_circRNA_000996 is upregulated in HCC and included in the final ceRNA network as part of the miR-136-5p/E2F1 axis (with other circRNAs). It is indirectly implicated in HCC progression via ceRNA-mediated regulation of the hub gene E2F1.	0.1768
39962534	Cell & bioscience	2025	CircRNA Itm2b induces oxidative stress via the interaction with Sirt1-Nox4 to aggravate sleep disturbances after traumatic brain injury.	mmu_circ_0005429	circItm2b	mmu_circ_Itm2b	Itm2b	traumatic brain injury / TBI	MONDO:0858950	traumatic brain injury	up-regulated	RT-qPCR; RNA-seq	"mmu_circ_0005429 (circItm2b) is up-regulated after TBI and worsens post-TBI sleep disturbances by binding Sirt1 to increase Nox4-associated mitochondrial oxidative stress, leading to loss of circadian proteins (Clock/Bmal1). Knockdown of circItm2b alleviates mitochondrial dysfunction and sleep-architecture abnormalities via the circItm2b/Sirt1/Nox4 axis."	0.8724
39962534	Cell & bioscience	2025	CircRNA Itm2b induces oxidative stress via the interaction with Sirt1-Nox4 to aggravate sleep disturbances after traumatic brain injury.	hsa_circ_0006620	circItm2b	hsa_circ_ITM2B	ITM2B	traumatic brain injury / TBI	MONDO:0858950	traumatic brain injury	up-regulated	RT-qPCR	"hsa_circ_0006620 is significantly up-regulated in serum (and elevated in contused brain tissue) of acute TBI patients and is associated with post-TBI sleep disturbance severity, showing positive correlations with PSQI/AIS and diagnostic value by ROC analysis."	0.4187
39963489	OncoTargets and therapy	2025	Comprehensive Analysis Identifies Hsa_circ_0058191 as a Potential Drug Resistance Target in Multiple Myeloma.	hsa_circ_0058191		hsa_circ_RPL37A	RPL37A	multiple myeloma / MM	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0058191 (from host gene RPL37A) is significantly up-regulated in bortezomib-resistant multiple myeloma patient samples and is proposed to contribute to bortezomib resistance. Bioinformatic analyses predict binding with miR-660 and the RBP AGO2, implicating it in RNA-related regulatory processes linked to drug resistance."	0.585
39964093	Molecular oncology	2025	CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR-15b-5p and miR-7-1-3p processing in nasopharyngeal carcinoma.		circCCNB1	hsa_circ_CCNB1	CCNB1	nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	down-regulated	RT-qPCR	"In nasopharyngeal carcinoma, circCCNB1 is down-regulated and suppresses vasculogenic mimicry. Mechanistically, circCCNB1 sequesters the RBP NF90, relieving NF90-mediated inhibition of pri-miR-15b and pri-miR-7-1 processing, thereby increasing miR-15b-5p/miR-7-1-3p and repressing CALU, KIF1B and POLR3G to reduce VM markers."	0.6412
39964719	Proceedings of the National Academy of Sciences of the United States of America	2025	"Viral circular RNA-encoded protein, ceVP28, divulges an antiviral response in invertebrates."		circWSSV147			white spot syndrome virus (WSSV) infection	MONDO:0005108	viral infectious disease	dysregulated	RT-qPCR; RNA-seq	circWSSV147 is a WSSV-derived circRNA identified from circRNA-seq data and detected in infected shrimp tissues; the study reports its expression profile during infection but does not define a specific mechanism or function for it.	0.5445
39964719	Proceedings of the National Academy of Sciences of the United States of America	2025	"Viral circular RNA-encoded protein, ceVP28, divulges an antiviral response in invertebrates."		circWSSV331			white spot syndrome virus (WSSV) infection	MONDO:0005108	viral infectious disease	dysregulated	RT-qPCR; RNA-seq	"circWSSV331 is a WSSV-derived circRNA detected in infected shrimp gill and hemocytes, with late-stage-biased detection (mainly at 72 hpi), but no specific antiviral/proviral function is experimentally assigned to it in this study."	0.5445
39964719	Proceedings of the National Academy of Sciences of the United States of America	2025	"Viral circular RNA-encoded protein, ceVP28, divulges an antiviral response in invertebrates."		circWSSV458			white spot syndrome virus (WSSV) infection	MONDO:0005108	viral infectious disease	dysregulated	RT-qPCR; RNA-seq	circWSSV458 is a WSSV-derived circRNA identified by circRNA-seq and detected/quantified by qRT-PCR in infected shrimp gill and hemocytes; the study does not provide a specific function or mechanism for circWSSV458 beyond infection-associated expression profiling and circRNA validation.	0.5445
39964719	Proceedings of the National Academy of Sciences of the United States of America	2025	"Viral circular RNA-encoded protein, ceVP28, divulges an antiviral response in invertebrates."		circVP28		VP28	white spot syndrome virus (WSSV) infection	MONDO:0005108	viral infectious disease	dysregulated	RT-qPCR; Northern Blot; RNA-seq	"In WSSV-infected shrimp, viral circVP28 is generated and translated via an IRES to produce ceVP28. ceVP28 binds the host receptor Rab7 with higher affinity than VP28 and competitively interferes with VP28_Rab7 interaction, reducing viral entry, viral copy numbers, and shrimp mortality."	0.7158
39965082	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2025	EIF4A3-Mediated Biogenesis of CircFADS1 Promotes the Progression of Hepatocellular Carcinoma via Wnt/beta-Catenin Pathway.	hsa_circ_0022378	circFADS1	hsa_circ_FADS1	FADS1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circFADS1 is up-regulated in HCC and promotes tumor cell proliferation while inhibiting apoptosis, including enhanced xenograft growth. Mechanistically, EIF4A3 promotes circFADS1 biogenesis; circFADS1 scaffolds RNF114 and GSK3beta to increase GSK3beta ubiquitination/degradation, thereby activating Wnt/beta-catenin signaling. circFADS1 also contributes to lenvatinib resistance."	0.8933
39966952	European journal of medical research	2025	Identification of a circRNA-mediated immune-related ceRNA network and circRNAs as diagnostic biomarkers in acute ischemic stroke.	hsa_circ_0129074	circOXCT1	hsa_circ_OXCT1	OXCT1	ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; Microarray	"circOXCT1 (hsa_circ_0129074) is upregulated in AIS patient plasma and shows diagnostic potential by ROC/logistic regression. It is predicted to function as a ceRNA by sequestering hsa-miR-445-5p to affect IFIT1, linking it to immune/inflammatory responses in AIS."	0.5849
39966952	European journal of medical research	2025	Identification of a circRNA-mediated immune-related ceRNA network and circRNAs as diagnostic biomarkers in acute ischemic stroke.	hsa_circ_0000994	circSLC8A1	hsa_circ_SLC8A1	SLC8A1	ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; Microarray	"circSLC8A1 (hsa_circ_0000994) is upregulated in AIS patient plasma and has diagnostic utility by ROC/logistic regression, with longitudinal changes suggesting monitoring potential. It is predicted to participate in a ceRNA axis involving hsa-miR-127-5p and the immune-related hub genes IFIT1/IFIT3."	0.5849
39967686	Frontiers in genetics	2025	Circular RNA microarray expression profile and potential function of circDOCK1 in colorectal cancer.		circDOCK1 / hsa_circDOCK1_024	hsa_circ_DOCK1	DOCK1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"In colorectal cancer, circDOCK1 is up-regulated in tumor tissues and functions as an oncogenic circRNA that promotes CRC cell proliferation, migration, and invasion. Clinically, higher circDOCK1 expression is associated with worse overall survival and is reported as an independent prognostic risk factor."	0.7041
39969065	The Kaohsiung journal of medical sciences	2025	IGF2BP2-induced circRNF20 facilitates breast cancer cell proliferation via the HuR/CDCA4 axis.		circRNA ring finger protein 20 / circRNF20	hsa_circ_RNF20	RNF20	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circRNF20 is up-regulated in breast cancer cell lines and promotes cancer cell proliferation. Mechanistically, IGF2BP2 stabilizes circRNF20, enabling circRNF20 to bind HuR and enhance CDCA4 expression, forming an IGF2BP2_circRNF20_HuR_CDCA4 pro-proliferative axis."	0.7799
39972489	Cancer cell international	2025	CircRNA hsa_circ_0004781 promoted cell proliferation by acting as a sponge for miR-9-5p and miR-338-3p and upregulating KLF5 and ADAM17 expression in pancreatic ductal adenocarcinoma.	hsa_circ_0004781	c4781	hsa_circ_PCNX1	PCNX1	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0004781 (from PCNX1 exons 2_5) is upregulated in PDAC and promotes PDAC cell proliferation and migration. Mechanistically, it sponges miR-9-5p and miR-338-3p to increase KLF5 and ADAM17 expression, respectively, supporting an oncogenic ceRNA axis and suggesting therapeutic potential."	0.7639
39973830	Indian journal of pharmacology	2024	Adipose-derived stem cells exosomal circHIPK3 protects ovarian function by regulating MAPK signaling.		circHIPK3	mmu_circ_HIPK3	HIPK3	ovarian aging	MONDO:0005387	primary ovarian failure	unknown	RT-qPCR	"This study shows ADSC-derived exosomal circHIPK3 protects against ovarian aging by improving ovarian function and follicular development and by enhancing primary granulosa cell viability while reducing senescence and apoptosis. Mechanistically, circHIPK3 interacts with p38 and beta-TrCP and modulates beta-TrCP-mediated ubiquitination of p38, impacting MAPK signaling."	0.6738
39978792	Diabetes & metabolism journal	2025	Validating Multicenter Cohort Circular RNA Model for Early Screening and Diagnosis of Gestational Diabetes Mellitus.	hsa_circ_0031560		hsa_circ_HEATR5A	HEATR5A	gestational diabetes mellitus / GDM	MONDO:0005406	gestational diabetes	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0031560 is derived from HEATR5A and is significantly upregulated in the serum of GDM patients (including early pregnancy women who later develop GDM). It shows diagnostic value by ROC analysis and contributes to a logistic-regression model (E-GDMM) for early prediction. Higher expression is also associated with increased risk of adverse pregnancy outcomes.	0.7256
39978792	Diabetes & metabolism journal	2025	Validating Multicenter Cohort Circular RNA Model for Early Screening and Diagnosis of Gestational Diabetes Mellitus.	hsa_circ_0000793		hsa_circ_USP32	USP32	gestational diabetes mellitus / GDM	MONDO:0005406	gestational diabetes	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000793 is derived from USP32 and is significantly upregulated in the serum of GDM patients (including early pregnancy women who later develop GDM). It has diagnostic value by ROC analysis and contributes to the E-GDMM logistic-regression model for early prediction. Higher expression is also associated with increased risk of adverse pregnancy outcomes, though its third-trimester levels are similar between GDM and controls."	0.7256
39980011	Biomarker research	2025	Multiple regulatory events contribute to a widespread circular RNA downregulation in precancer and early stage of colorectal cancer development.		"circLPAR1(2,3)"	hsa_circ_LPAR1	LPAR1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"circLPAR1(2,3) is down-regulated in colorectal tumor and adenoma tissues versus matched adjacent mucosa. Lower circLPAR1(2,3) levels are associated with better overall survival in CRC patients in this cohort."	0.3872
39980011	Biomarker research	2025	Multiple regulatory events contribute to a widespread circular RNA downregulation in precancer and early stage of colorectal cancer development.		circLINC00632(5) / ciRS-7	hsa_circ_LINC00632	LINC00632	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"circLINC00632(5) is down-regulated in colorectal tumor and adenoma tissues versus matched adjacent mucosa, and this downregulation is validated by ddPCR in clinical tissues."	0.3872
39981141	Analytical cellular pathology (Amsterdam)	2025	Circular RNA Circ_0079226 Plays an Oncogenic Role in Gastric Cancer via the miR-155-5p/FOXK1/AKT Pathway.	hsa_circ_0079226	circ_0079226	hsa_circ_FOXK1	FOXK1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; ISH	"circ_0079226 is up-regulated in gastric cancer tissues and cell lines and promotes proliferation, migration, invasion, EMT-like changes, and xenograft tumor growth. Mechanistically, it sponges miR-155-5p to derepress FOXK1 and enhance downstream FAK/AKT signaling."	0.7373
39981261	Frontiers in genetics	2025	Noncoding RNA profiling in omentum adipose tissue from obese patients and the identification of novel metabolic biomarkers.	hsa_circ_0000722		hsa_circ_GSE1	GSE1	obesity	MONDO:0011122	obesity disorder	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0000722 is up-regulated in greater omentum adipose tissue from obese individuals. It was included in a ceRNA network and predicted to regulate metabolic gene G6PD via sponging hsa-miR-326_R+1.	0.4032
39981261	Frontiers in genetics	2025	Noncoding RNA profiling in omentum adipose tissue from obese patients and the identification of novel metabolic biomarkers.	hsa_circ_0003410	circRNA3410	hsa_circ_GARS1-DT	GARS1-DT	obesity	MONDO:0011122	obesity disorder	down-regulated	RT-qPCR; RNA-seq	"circRNA3410 is down-regulated in greater omentum adipose tissue of obese individuals. It was incorporated into a ceRNA network and predicted to be targeted by two miRNAs that regulate metabolic genes including G6PD, ACACA and GLUL."	0.4032
39981261	Frontiers in genetics	2025	Noncoding RNA profiling in omentum adipose tissue from obese patients and the identification of novel metabolic biomarkers.	hsa_circ_0003245	circRNA3245	hsa_circ_CSNK1E	CSNK1E	obesity	MONDO:0011122	obesity disorder	down-regulated	RT-qPCR; RNA-seq	"circRNA3245 is down-regulated in greater omentum adipose tissue of obese individuals. It was incorporated into a ceRNA network and predicted to interact with mmu-miR-1934-5p_1ss8TA, linking it to metabolic genes such as G6PD and ACO2."	0.4032
39981261	Frontiers in genetics	2025	Noncoding RNA profiling in omentum adipose tissue from obese patients and the identification of novel metabolic biomarkers.	hsa_circ_0003268	circRNA3268	hsa_circ_TUT7	TUT7	obesity	MONDO:0011122	obesity disorder	down-regulated	RT-qPCR; RNA-seq	"circRNA3268 is down-regulated in greater omentum adipose tissue of obese individuals. It was incorporated into a ceRNA network and predicted to be targeted by two miRNAs that regulate metabolic genes including G6PD, TPI1 and ACLY."	0.4032
39987600	Poultry science	2025	Circular RNA Vav3 mediated ALV-J inhibition of autophagy by modulating the gga-miR-375/CIP2A axis and activating AKT.		circ-Vav3 / circular RNA Vav3	gga_circ_Vav3	Vav3	ALV-J infection	MONDO:0005108	viral infectious disease	up-regulated	RT-qPCR; RNA-seq	"circ-Vav3 is up-regulated in ALV-J-induced chicken tumor livers and inhibits autophagy. Mechanistically, it acts as a ceRNA sponge for gga-miR-375 to increase CIP2A expression, which blocks autophagosome_lysosome fusion and activates AKT signaling, thereby mediating ALV-J-associated autophagy inhibition."	0.6376
39988592	Cell death & disease	2025	Glycolysis reprogramming in CAFs promotes oxaliplatin resistance in pancreatic cancer through circABCC4 mediated PKM2 nuclear translocation.	hsa_circ_0030582	circABCC4	hsa_circ_ABCC4	ABCC4	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circABCC4 is up-regulated in CAFs and PDAC tissues from oxaliplatin-resistant patients and promotes oxaliplatin resistance. It directly associates with PKM2 and KPNA2 to enhance PKM2 nuclear translocation in CAFs, driving glycolysis reprogramming and IL-8 secretion, which reduces DNA damage in PDAC cells and supports chemoresistance. High circABCC4 predicts poor oxaliplatin response and shorter PFS."	0.8988
39990843	Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition	2024	[circ_0084043/miR-31-5p Is Involved in Atherosclerosis by Regulating HMGA1: Investigation of the Mechanisms].	hsa_circ_0084043	circ_0084043			atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"circ_0084043 is up-regulated in atherosclerotic plaque/diseased vascular tissues and promotes ox-LDL-induced VSMC proliferation, migration and invasion. Mechanistically, it binds miR-31-5p to relieve repression of HMGA1, thereby accelerating AS progression; silencing circ_0084043 alleviates lesions in an AS mouse model."	0.7132
39994725	Molecular cancer	2025	CircAKT3 promotes prostate cancer proliferation and metastasis by enhancing the binding of RPS27A and RPL11.	hsa_circ_0017252	circAKT3	hsa_circ_AKT3	AKT3	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; RNA-seq	"circAKT3 is up-regulated in prostate cancer and promotes proliferation, migration, invasion and metastasis. It acts mainly as a protein scaffold that strengthens RPS27A_RPL11 binding and reduces nuclear RPL11, thereby relieving RPL11 inhibition of c-Myc and enhancing c-Myc-mediated repression of MST1."	0.8621
39995883	Journal of cell communication and signaling	2025	Hsa_circ_0000515 sequesters microRNA-296-5p and elevates RNF44 expression to encourage the NSCLC progression.	hsa_circ_0000515	hsa_circ_515 / circ_515	hsa_circ_RPPH1	RPPH1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"In NSCLC, circ_515 is up-regulated and promotes malignant phenotypes (proliferation, migration/invasion, EMT, tumor growth) while inhibiting apoptosis. Mechanistically, it mainly acts as a cytoplasmic ceRNA that sponges miR-296-5p to de-repress RNF44, forming a circ_515/miR-296-5p/RNF44 axis. High circ_515 expression is associated with worse patient survival and more aggressive clinicopathological features."	0.8498
39996735	Cells	2025	Circular RNA ZNF277 Sponges miR-378d to Inhibit the Intracellular Survival of Mycobacterium tuberculosis by Upregulating Rab10.	hsa_circ_0001739	circ-ZNF277	hsa_circ_ZNF277	ZNF277	tuberculosis / TB	MONDO:0018076	tuberculosis	up-regulated	RT-qPCR; RNA-seq	"circ-ZNF277 is up-regulated upon Mtb infection in THP-1 macrophages and mainly localizes to the cytoplasm. It sponges miR-378d to relieve repression of Rab10, thereby activating NF-kappaB signaling and increasing IL-1beta/IL-6/TNF-alpha secretion, which reduces intracellular Mtb survival."	0.7353
39998739	Human cell	2025	CircTBCK protects against osteoarthritis by regulating extracellular matrix and autophagy.		circTBCK	mmu_circ_TBCK	TBCK	osteoarthritis / OA	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR	"circTBCK is down-regulated in osteoarthritis models (IL-1beta-treated chondrocytes and DMM mouse cartilage). Functionally, circTBCK overexpression mitigates OA-like chondrocyte degeneration by promoting proliferation, supporting ECM anabolism (Collagen II/SOX9), and enhancing autophagy/autophagic flux, while circTBCK knockdown worsens these phenotypes."	0.6993
40001070	Molecular cancer	2025	EIF4E-mediated biogenesis of circPHF14 promotes the growth and metastasis of pancreatic ductal adenocarcinoma via Wnt/beta-catenin pathway.	hsa_circ_0079440	circPHF14	hsa_circ_PHF14	PHF14	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circPHF14 is upregulated in PDAC and promotes proliferation, migration/invasion, tumor growth and metastasis. It predominantly localizes to the cytoplasm and binds the RBP PABPC1 to stabilize WNT7A mRNA via the WNT7A 3¡¯-UTR, activating Wnt/beta-catenin signaling and upregulating SNAI2 to drive EMT. EIF4E enhances circPHF14 biogenesis by binding specific flanking intronic regions in PHF14 pre-mRNA, and high circPHF14 predicts poor survival."	0.8981
40003874	International journal of molecular sciences	2025	Identifying Essential Hub Genes and circRNA-Regulated ceRNA Networks in Hepatocellular Carcinoma.	hsa_circ_0000943	circ_0000943			Hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ_0000943 is upregulated in HCC and its knockdown decreases HCC cell viability and motility. However, the predicted ceRNA network relationships tested for circ_0000943 were not validated in the authors¡¯ assays."	0.5627
40003874	International journal of molecular sciences	2025	Identifying Essential Hub Genes and circRNA-Regulated ceRNA Networks in Hepatocellular Carcinoma.	hsa_circ_0008346	circ_0008346	hsa_circ_NUSAP1	NUSAP1	Hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ_0008346 is upregulated in HCC and supports HCC cell proliferation/motility, since ASO knockdown reduced viability and motility. The predicted circ_0008346-centered ceRNA networks tested were not validated by miRNA/hub gene expression responses."	0.4469
40003874	International journal of molecular sciences	2025	Identifying Essential Hub Genes and circRNA-Regulated ceRNA Networks in Hepatocellular Carcinoma.	hsa_circ_0001345	circ_0001345			Hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ_0001345 is upregulated in HCC and supports HCC cell proliferation/motility. Mechanistically, it acts as a ceRNA that sponges miR-17-5p/miR-20a-5p/miR-93-5p/miR-519d-3p to promote KPNA2 expression."	0.593
40003874	International journal of molecular sciences	2025	Identifying Essential Hub Genes and circRNA-Regulated ceRNA Networks in Hepatocellular Carcinoma.	hsa_circ_0103672	circ_0103672			Hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ_0103672 is upregulated in HCC and supports proliferation/motility of HCC cells. It functions as a ceRNA regulating OIP5 via miR-103a-3p, with additional miR-195-5p-related target regulation only partially supported depending on cell line."	0.4469
40007573	Biochemistry and biophysics reports	2025	Comprehensive analysis of differential mRNA and circRNA profiles in primary and metastatic pancreatic neuroendocrine tumors.	hsa_circ_0004365	hsa_circRNA_104421	hsa_circ_SEMA3C	SEMA3C	pancreatic neuroendocrine tumors / pNETs	MONDO:0019954	pancreatic neuroendocrine tumor	up-regulated	RT-qPCR; Microarray	"hsa_circ_0004365 (from SEMA3C) is significantly upregulated from adjacent tissue to primary pNET and further to liver metastasis in patient samples. The study builds a predicted ceRNA network for hsa_circ_0004365 and reports pathway enrichments (including apoptosis and NK cell-mediated cytotoxicity), supporting its potential as a biomarker for pNET tumorigenesis and metastasis."	0.5135
40007573	Biochemistry and biophysics reports	2025	Comprehensive analysis of differential mRNA and circRNA profiles in primary and metastatic pancreatic neuroendocrine tumors.	hsa_circ_0012779	hsa_circRNA_100247	hsa_circ_INADL	INADL	pancreatic neuroendocrine tumors / pNETs	MONDO:0019954	pancreatic neuroendocrine tumor	up-regulated	Microarray	"hsa_circ_0012779 (from INADL) is identified by circRNA microarray as upregulated along pNET progression/metastasis and is included in a predicted ceRNA network. Its RT-qPCR trend is upward but not statistically significant, so evidence for differential expression is weaker than for hsa_circ_0004365."	0.329
40007573	Biochemistry and biophysics reports	2025	Comprehensive analysis of differential mRNA and circRNA profiles in primary and metastatic pancreatic neuroendocrine tumors.	hsa_circ_0087104	hsa_circRNA_104785	hsa_circ_CNTNAP3	CNTNAP3	pancreatic neuroendocrine tumors / pNETs	MONDO:0019954	pancreatic neuroendocrine tumor	up-regulated	Microarray	"hsa_circ_0087104 (from CNTNAP3) is identified by circRNA microarray as upregulated along pNET progression/metastasis and is included in a predicted ceRNA network. Its RT-qPCR validation is not reported as statistically significant, so evidence for its differential expression is limited."	0.329
40008007	Frontiers in oncology	2025	Co-modulation of a circular form of PCDH11Y during neuroendocrine differentiation of prostate cancer.		circPCDH11Y / Circular PCDH11Y	hsa_circ_PCDH11Y	PCDH11Y	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; RNA-seq	"circPCDH11Y is strongly up-regulated during neuroendocrine transdifferentiation of AR-dependent LNCaP prostate cancer cells and is detectable in LNCaP-derived extracellular vesicles after NED. Knockdown of circPCDH11Y modulates key NED markers (SYP, ENO2, PSA, BRN2, and linear PCDH11Y), supporting a role in promoting or timing neuroendocrine differentiation and suggesting biomarker potential for t-NEPC."	0.642
40008750	Molecular oncology	2025	Transcriptome-wide analysis of circRNA and RBP profiles and their molecular relevance for GBM.		circARID1A	hsa_circ_ARID1A	ARID1A	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; RNA-seq	"circARID1A is up-regulated in GBM and is predominantly localized in the cytoplasm. siRNA-mediated circARID1A knockdown decreases proliferation in U-251 MG and U-118 MG cells, suggesting an oncogenic pro-proliferative role in GBM."	0.4713
40008750	Molecular oncology	2025	Transcriptome-wide analysis of circRNA and RBP profiles and their molecular relevance for GBM.		circGUSBP1	hsa_circ_GUSBP1	GUSBP1	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; RNA-seq	"circGUSBP1 is up-regulated in GBM and mainly localized in the nucleus. It physically interacts with the RBP FUS as supported by CLIP/Co-IP-RT-qPCR enrichment, suggesting a circRNA/RBP interaction role in GBM."	0.6324
40008750	Molecular oncology	2025	Transcriptome-wide analysis of circRNA and RBP profiles and their molecular relevance for GBM.		circPLOD2	hsa_circ_PLOD2	PLOD2	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; RNA-seq	"circPLOD2 is up-regulated in GBM and localized in both nucleus and cytoplasm. It can bind the RBP FUS in CLIP-based assays, but its knockdown did not produce functional relevant proliferation changes under the tested conditions."	0.6783
40008750	Molecular oncology	2025	Transcriptome-wide analysis of circRNA and RBP profiles and their molecular relevance for GBM.		circVCAN	hsa_circ_VCAN	VCAN	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; RNA-seq	"circVCAN is one of the most up-regulated circRNAs in primary GBM samples and is mainly nuclear. It directly interacts with the RBP FUS as supported by CLIP enrichment, indicating a circRNA/RBP interaction relevant to GBM."	0.6324
40008750	Molecular oncology	2025	Transcriptome-wide analysis of circRNA and RBP profiles and their molecular relevance for GBM.		circCADPS2	hsa_circ_CADPS2	CADPS2	glioblastoma / GBM	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR; RNA-seq	"circCADPS2 was identified as a down-regulated circRNA in primary GBM versus healthy brain and was included among circRNAs experimentally validated for circularity/expression, but no specific functional mechanism was characterized in this paper."	0.3401
40008750	Molecular oncology	2025	Transcriptome-wide analysis of circRNA and RBP profiles and their molecular relevance for GBM.		circEPB41L5 / circEBP41L5	hsa_circ_EPB41L5	EPB41L5	glioblastoma / GBM	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR; RNA-seq	circEPB41L5/circEBP41L5 is strongly down-regulated in primary GBM compared with healthy brain and shows a notable discrepancy between circular and linear transcript levels; this study did not functionally characterize it beyond expression/circularity validation.	0.3401
40008750	Molecular oncology	2025	Transcriptome-wide analysis of circRNA and RBP profiles and their molecular relevance for GBM.		circUNC13C	hsa_circ_UNC13C	UNC13C	glioblastoma / GBM	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR; RNA-seq	circUNC13C is down-regulated in primary GBM versus healthy brain and was among the circRNAs selected for experimental validation. The study did not report a specific functional mechanism for circUNC13C.	0.3401
40008750	Molecular oncology	2025	Transcriptome-wide analysis of circRNA and RBP profiles and their molecular relevance for GBM.		circUSP45	hsa_circ_USP45	USP45	glioblastoma / GBM	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR; RNA-seq	"circUSP45 was identified as a down-regulated circRNA in primary GBM versus healthy brain and was among circRNAs selected for experimental validation, but no functional mechanism was described for it in this study."	0.3401
40008750	Molecular oncology	2025	Transcriptome-wide analysis of circRNA and RBP profiles and their molecular relevance for GBM.	hsa_circ_0080229	circEGFR	hsa_circ_EGFR	EGFR	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; RNA-seq	"circEGFR (hsa_circ_0080229) is up-regulated in recurrent GBM compared with primary GBM, with very large fold-change by RT-qPCR, and is proposed as a progression-associated circRNA marker in this dataset; no direct functional mechanism was established in this paper."	0.3401
40008750	Molecular oncology	2025	Transcriptome-wide analysis of circRNA and RBP profiles and their molecular relevance for GBM.		circHLA-B	hsa_circ_HLA-B	HLA-B	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; RNA-seq	circHLA-B is a newly identified recurrent-GBM_associated circRNA (up-regulated in GBM-REC vs GBM-PRM) and was included in the RT-qPCR validation set; no functional mechanism was determined in this work.	0.3401
40008750	Molecular oncology	2025	Transcriptome-wide analysis of circRNA and RBP profiles and their molecular relevance for GBM.		circInter6p22	hsa_circ_Inter6p22		glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RNA-seq	"circInter6p22 is an intergenic circRNA (from chromosome 6p22.1) identified by RNA-seq as up-regulated in recurrent GBM versus primary GBM, suggested as a progression-associated marker; no direct experimental validation or mechanism was reported in the provided text."	0.1768
40008841	The Kaohsiung journal of medical sciences	2025	Circular RNA circCD44 targets methyltransferase-like 3/homeobox containing 1 to facilitate esophageal squamous cell carcinoma progression.		circCD44	hsa_circ_CD44	CD44	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"circCD44 is up-regulated in ESCC cell lines and promotes ESCC cell proliferation and invasion while inhibiting apoptosis, and it enhances xenograft tumor growth. Mechanistically, circCD44 binds the RBP METTL3, increasing METTL3-dependent m6A modification of HMBOX1 mRNA and thereby elevating HMBOX1 expression to drive ESCC progression."	0.5992
40011917	Molecular cancer	2025	Hsa_circ_0125356 promotes gemcitabine resistance by modulating WNT canonical and non-canonical pathways via miR-582-5p/FGF9 axis in non-small cell lung cancer.	hsa_circ_0125356	circ_0125356 / CircRNA-0125356	hsa_circ_SLC7A11	SLC7A11	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"hsa_circ_0125356 is upregulated in NSCLC and promotes gemcitabine resistance. It functions as a ceRNA by sponging miR-582-5p to upregulate FGF9, thereby activating canonical and non-canonical WNT signaling, enhancing DNA damage repair and reducing apoptosis; high expression is associated with poorer survival."	0.873
40013670	Cancer medicine	2025	circFOXK2 Stabilizes STMN1 mRNA via PABPC1 to Promote the Progression of NSCLC.	hsa_circ_0046430	circFOXK2	hsa_circ_FOXK2	FOXK2	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"circFOXK2 (hsa_circ_0046430) is up-regulated in NSCLC tissues and cell lines and promotes proliferation, migration, invasion, EMT and in vivo tumor growth/metastasis. Mechanistically, it localizes mainly to the cytoplasm and forms a complex with the RBP PABPC1 to stabilize STMN1 mRNA, thereby increasing STMN1 expression; the effect is not mediated by miRNA sponging."	0.8932
40016838	European journal of medical research	2025	circZNF707 promoted glycolysis and tumor progression through miR-668-3p-PFKM axis in NSCLC.	hsa_circ_0006566	circZNF707	hsa_circ_ZNF707	ZNF707	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circZNF707 is up-regulated in NSCLC tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation, migration, invasion, and glycolysis by sponging miR-668-3p to upregulate PFKM, and its knockdown suppresses tumor growth in a nude-mouse xenograft model."	0.8539
40021969	BMC cardiovascular disorders	2025	Identification of the CeRNA axis of circ_0000006/miR-483-5p/KDM2B in the progression of aortic aneurysm to aorta dissection.	hsa_circ_0000006	circ_0000006			aortic dissection / AD	MONDO:0022470	aortic dissection lentiginosis	up-regulated	RT-qPCR; Microarray	"circ_0000006 is up-regulated during progression from AA to AD. It promotes PDGF-induced VSMC phenotypic switching, proliferation, and migration via a ceRNA mechanism involving miR-483-5p and KDM2B, and its knockdown alleviates AD progression in a mouse model."	0.6593
40022084	Journal of translational medicine	2025	Hsa_circ_0002301 inhibits ferroptosis in gastric cancer by encoding the de novo protein HECTD1-463aa.	hsa_circ_0002301		hsa_circ_HECTD1	HECTD1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0002301 is up-regulated in gastric cancer and promotes malignant phenotypes. It inhibits ferroptosis by encoding the peptide HECTD1-463aa, which binds HECTD1 and reduces HECTD1-mediated GPX4 ubiquitination/degradation, stabilizing GPX4. High hsa_circ_0002301 expression is associated with worse overall survival and more aggressive clinicopathological features."	0.8949
40025553	Stem cell research & therapy	2025	Inhibition of circALPK2 enhances proliferation and therapeutic potential of human pluripotent stem cell-derived cardiomyocytes in myocardial infarction.		circALPK2 / circRNA ALPK2	hsa_circ_ALPK2	ALPK2	myocardial infarction / MI	MONDO:0005068	myocardial infarction	unknown	RT-qPCR	"circALPK2 inhibits proliferation of hESC-derived cardiomyocytes and limits cardiac repair after MI cell therapy. Mechanistically, circALPK2 sponges miR-9 to de-repress GSK3B, thereby inhibiting WNT signaling; circALPK2 knockdown enhances proliferation, engraftment/retention and improves cardiac function in MI mice after hESC-CM transplantation."	0.7009
40027648	bioRxiv : the preprint server for biology	2025	Synergistic RAS-MAPK and AKT Activation in MYC-Driven Tumors via Adjacent PVT1 Rearrangements.		CircPVT1	hsa_circ_PVT1	PVT1	cancer	MONDO:0004992	cancer	up-regulated	RT-qPCR	"CircPVT1 is enriched in MYC/PVT1-rearranged MYC+ cancer cell lines and encodes the peptide Firefox (FFX). FFX promotes proliferation and enhances MYC and mTORC1 activity by activating AKT signaling, at least in part via interaction with AUF1."	0.6683
40033018	The EMBO journal	2025	Noncanonical circRNA biogenesis driven by alpha and gamma herpesviruses.		circLAT_KT899744.1: 6137-6814 / circLAT	hsv_circ_LAT	LAT	Herpes simplex virus-1 / HSV-1 lytic infection	MONDO:0004609	herpes simplex infectious disease	unknown	RT-qPCR; RNA-seq	This study identifies and validates an HSV-1 LAT-derived circRNA (circLAT_KT899744.1: 6137-6814) expressed in lytic and latent infection models. The authors further provide in silico evidence suggesting circLAT could participate in a ceRNA-like network involving hsa-miR-124-3p and cellular senescence-related targets.	0.6631
40033018	The EMBO journal	2025	Noncanonical circRNA biogenesis driven by alpha and gamma herpesviruses.		circK12	kshv_circ_K12	K12	KSHV infection	MONDO:0005550	infectious disease	unknown	RNA-seq	"This study reports KSHV circK12 as a viral circRNA expressed across lytic, latent, and reactivation models. The authors provide computational predictions suggesting circK12 could participate in a ceRNA-like network and may relate to PI3K/AKT/mTOR signaling via AKT3."	0.1768
40033018	The EMBO journal	2025	Noncanonical circRNA biogenesis driven by alpha and gamma herpesviruses.		circORF66	mhv68_circ_ORF66	ORF66	MHV68 infection	MONDO:0005550	infectious disease	unknown	RNA-seq	"This study identifies MHV68 circORF66 as a viral circRNA present across lytic, latent, and reactivation models, and includes it in predicted circRNA_miRNA_mRNA network analyses."	0.31
40033018	The EMBO journal	2025	Noncanonical circRNA biogenesis driven by alpha and gamma herpesviruses.		circICP0-exon2 / circICP0	hsv_circ_ICP0	ICP0	Herpes simplex virus-1 / HSV-1 lytic infection	MONDO:0004609	herpes simplex infectious disease	unknown	RT-qPCR; RNA-seq	"This study detects an HSV-1 circRNA arising from the middle exon of ICP0 and shows its circularization is reduced upon depletion of host RNA ligases (RLIG1 and RTCB), supporting a noncanonical, RNA ligase-linked biogenesis mechanism for this viral circRNA."	0.3213
40033018	The EMBO journal	2025	Noncanonical circRNA biogenesis driven by alpha and gamma herpesviruses.		circPAN / circPAN [28646:29488]	kshv_circ_PAN	PAN	KSHV infection	MONDO:0005550	infectious disease	dysregulated	RT-qPCR; RNA-seq	"This study identifies circPAN as a major KSHV lytic circRNA and shows that the viral RBP ORF57 binds near circPAN back-splice junctions and reshapes circPAN species diversity, with a distinct circPAN [28646:29488] becoming highly abundant in deltaORF57 cells. The abundance of circPAN is also sensitive to depletion of host RNA ligases (RTCB)."	0.4713
40033018	The EMBO journal	2025	Noncanonical circRNA biogenesis driven by alpha and gamma herpesviruses.		circK2	kshv_circ_K2	K2	KSHV infection	MONDO:0005550	infectious disease	unknown	RT-qPCR; RNA-seq	"This study identifies circK2 as a KSHV lytic circRNA hotspot and shows that its circularization is decreased by depletion of the host RNA ligase RTCB, supporting RNA ligase-linked, noncanonical circRNA biogenesis for at least some viral loci."	0.3213
40033018	The EMBO journal	2025	Noncanonical circRNA biogenesis driven by alpha and gamma herpesviruses.		circvIRF4	kshv_circ_vIRF4	vIRF4	KSHV infection	MONDO:0005550	infectious disease	unknown	RT-qPCR; RNA-seq	"This study identifies circvIRF4 as a major KSHV circRNA and shows that, unlike circPAN, its expression is largely unchanged in deltaORF57 versus WT, while ORF57 eCLIP indicates ORF57 binds near back-spliced junctions for a subset of viral circRNAs."	0.3401
40038566	Renal failure	2025	Curcumin alleviates renal fibrosis in chronic kidney disease by targeting the circ_0008925-related pathway.	hsa_circ_0008925	Circ_0008925	hsa_circ_SEC63	SEC63	chronic kidney disease / CKD	MONDO:0005300	chronic kidney disease	up-regulated	RT-qPCR	"In renal fibrosis/CKD models, circ_0008925 is up-regulated and mainly cytoplasmic. It promotes HK-2 cell injury and fibrosis by sponging miR-204-5p to increase IL6ST, while curcumin alleviates fibrosis partly by lowering circ_0008925 and inhibiting the circ_0008925/miR-204-5p/IL6ST axis."	0.7223
40041405	Journal of immunology research	2025	Plasma-Derived Neuronal Exosomal CircRNAs as Potential Biomarkers for Central Nervous System Infections.	hsa_circ_0020840	hsa_circ__0020840			infections of central nervous system / ICNSs	MONDO:0024619	central nervous system infectious disorder	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0020840 is elevated in plasma brain-derived exosomes from patients with bacterial CNS infections and is proposed as a noninvasive diagnostic biomarker. Its potential functional relevance was explored only via GO/KEGG enrichment, without mechanistic experiments in ICNSs."	0.5047
40041405	Journal of immunology research	2025	Plasma-Derived Neuronal Exosomal CircRNAs as Potential Biomarkers for Central Nervous System Infections.	hsa_circ_0116108	circPKNOX1	hsa_circ_PKNOX1	PKNOX1	infections of central nervous system / ICNSs	MONDO:0024619	central nervous system infectious disorder	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0116108 (circPKNOX1) is elevated in plasma brain-derived exosomes from patients with bacterial CNS infections and is proposed as a diagnostic biomarker. The study did not experimentally test its mechanistic role in ICNSs beyond enrichment analysis.	0.5047
40041405	Journal of immunology research	2025	Plasma-Derived Neuronal Exosomal CircRNAs as Potential Biomarkers for Central Nervous System Infections.	hsa_circ_0056947				infections of central nervous system / ICNSs	MONDO:0024619	central nervous system infectious disorder	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0056947 is elevated in plasma brain-derived exosomes from patients with viral CNS infections and is proposed as a diagnostic indicator for viral ICNSs. The study did not perform mechanistic functional assays for this circRNA in ICNSs.	0.5047
40041405	Journal of immunology research	2025	Plasma-Derived Neuronal Exosomal CircRNAs as Potential Biomarkers for Central Nervous System Infections.	hsa_circ_0021531	hsa_scirc_0021531			infections of central nervous system / ICNSs	MONDO:0024619	central nervous system infectious disorder	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0021531 is elevated in plasma brain-derived exosomes from patients with viral CNS infections and is proposed as a diagnostic indicator to distinguish viral ICNSs. No mechanistic functional assays were performed for this circRNA in ICNSs.	0.5047
40041896	Acta pharmaceutica Sinica. B	2025	N 6-Methyladenosine modification of circDcbld2 in Kupffer cells promotes hepatic fibrosis via targeting miR-144-3p/Et-1 axis.	hsa_circ_0066631	circDcbld2	hsa_circ_DCBLD2	Dcbld2	hepatic fibrosis / HF	MONDO:0005155	cirrhosis of liver	up-regulated	RT-qPCR; RNA-seq	"circDcbld2 is up-regulated in hepatic fibrosis (mouse KCs/BMDMs and human fibrotic liver) and promotes inflammation, oxidative stress, HSC activation and fibrogenesis. Wtap-mediated m6A modification and Igf2bp2 recognition increase circDcbld2 stability, and circDcbld2 sponges miR-144-3p to up-regulate Et-1."	0.8794
40041896	Acta pharmaceutica Sinica. B	2025	N 6-Methyladenosine modification of circDcbld2 in Kupffer cells promotes hepatic fibrosis via targeting miR-144-3p/Et-1 axis.	mmu_circ_0000693	circDcbld2	mmu_circ_Dcbld2	Dcbld2	hepatic fibrosis / HF	MONDO:0005155	cirrhosis of liver	up-regulated	RT-qPCR; RNA-seq	"circDcbld2 is up-regulated in hepatic fibrosis (mouse KCs/BMDMs and human fibrotic liver) and promotes inflammation, oxidative stress, HSC activation and fibrogenesis. Wtap-mediated m6A modification and Igf2bp2 recognition increase circDcbld2 stability, and circDcbld2 sponges miR-144-3p to up-regulate Et-1."	0.8794
40044829	Scientific reports	2025	piRNAs and circRNAs acting as diagnostic biomarkers in clear cell renal cell carcinoma.	hsa_circ_0038076	circABCC1 / hsa circABCC1_011	hsa_circ_ABCC1	ABCC1	clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR; RNA-seq	"circABCC1 is up-regulated in ccRCC tumor tissues versus adjacent tissues and shows diagnostic potential (AUC reported), also contributing to a combined diagnostic model with improved AUC."	0.5047
40044829	Scientific reports	2025	piRNAs and circRNAs acting as diagnostic biomarkers in clear cell renal cell carcinoma.	hsa_circ_0003520	circNETO2_006 / hsa_circNETO2_006	hsa_circ_NETO2	NETO2	clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR; RNA-seq	"circNETO2_006 is up-regulated in ccRCC tumor tissues versus adjacent tissues and has diagnostic value (AUC reported), also included in a combined diagnostic model with improved AUC."	0.5047
40044829	Scientific reports	2025	piRNAs and circRNAs acting as diagnostic biomarkers in clear cell renal cell carcinoma.	hsa_circ_0004381	circARID1B_037 / hsa_circARID1B_037	hsa_circ_ARID1B	ARID1B	clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	down-regulated	RT-qPCR; RNA-seq	"circARID1B_037 is down-regulated in ccRCC tumor tissues versus adjacent tissues and has diagnostic value (AUC reported), also included in a combined diagnostic model with improved AUC."	0.5047
40045742	Turkish journal of haematology : official journal of Turkish Society of Haematology	2025	hsa_circRNA_092488 Exacerbates the Progression of Deep Vein Thrombosis Through the NLRP3/NF-kappaB Signaling Pathway.		hsa_circRNA_092488			Deep Vein Thrombosis / DVT	MONDO:0005399	venous thromboembolism	up-regulated	RT-qPCR	"hsa_circRNA_092488 is up-regulated in venous blood from DVT patients. Functionally, it impairs EPC proliferation and migration, induces S-to-G0/G1 cell-cycle arrest, and promotes apoptosis. Mechanistically, it binds NLRP3, increases NLRP3 mRNA stability, and activates NLRP3/NF-kappaB signaling with increased inflammatory/caspase-1/IL-1beta-related proteins."	0.7416
40046960	Frontiers in cardiovascular medicine	2025	Identification and validation of key genes associated with cell senescence in acute myocardial infarction.	hsa_circ_0000780				acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	unknown	Microarray	"hsa-circ-0000780 was identified by circRNA microarray and bioinformatics filtering as a candidate circRNA in an AMI-related ceRNA network, predicted to bind hsa-miR-330-5p and thereby relate to DYNLL1 regulation. The study did not experimentally validate its expression change or functional effects in AMI."	0.1768
40046960	Frontiers in cardiovascular medicine	2025	Identification and validation of key genes associated with cell senescence in acute myocardial infarction.	hsa_circ_0001726				acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	unknown	Microarray	"hsa-circ-0001726 was computationally included as one of four circRNAs in a DYNLL1-centered AMI ceRNA network, predicted to sponge hsa-miR-330-5p. No wet-lab validation of this circRNA was reported."	0.1768
40046960	Frontiers in cardiovascular medicine	2025	Identification and validation of key genes associated with cell senescence in acute myocardial infarction.	hsa_circ_0000517				acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	unknown	Microarray	hsa-circ-0000517 was predicted (microarray + StarBase-based filtering) to participate in an AMI ceRNA axis by interacting with hsa-miR-330-5p and linking to DYNLL1. The paper provides no experimental validation for this circRNA.	0.1768
40046960	Frontiers in cardiovascular medicine	2025	Identification and validation of key genes associated with cell senescence in acute myocardial infarction.	hsa_circ_0000893				acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	unknown	Microarray	hsa-circ-0000893 was identified via circRNA microarray and in-silico ceRNA construction as a putative regulator in an AMI-associated circRNA_miR-330-5p_DYNLL1 axis. The paper does not provide experimental validation for this circRNA.	0.1768
40048447	PLoS genetics	2025	Species-specific circular RNA circDS-1 enhances adaptive evolution in Talaromyces marneffei through regulation of dimorphic transition.		circDS-1 / circTM020485		TM020485	Talaromycosis	MONDO:0000304	penicilliosis	up-regulated	RT-qPCR; RNA-seq	"In Talaromyces marneffei, circDS-1 (also termed circTM020485) is yeast-enriched and promotes the hyphae-to-yeast dimorphic transition while maintaining yeast morphology. Loss or knockdown of circDS-1 impairs yeast formation and reduces virulence in a macrophage infection setting, and its biogenesis depends on a species-specific intronic flanking region likely involving KH-type RBP-mediated circularization."	0.6262
40050914	Molecular cancer	2025	Circular RNA circCLASP2 promotes nasopharyngeal carcinoma progression through binding to DHX9 to enhance PCMT1 translation.	hsa_circ_0001280	circCLASP2	hsa_circ_CLASP2	CLASP2	nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circCLASP2 is up-regulated in nasopharyngeal carcinoma and promotes proliferation and metastasis. It functions as a scaffold that increases DHX9 association with PCMT1 mRNA, enabling DHX9 to unwind an inhibitory rG4 near the translation start site and thereby enhance PCMT1 translation, strengthening cytoskeletal dynamics and driving malignancy."	0.8468
40050987	Journal of translational medicine	2025	HAS-CIRCpedia-5280 sponges miR-4712-5p inhibited colon cancer autophagyinduced by human beta-defensin-1.		hsa-CIRCpedia-5280	hsa_circ_LRP5	LRP5	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq; Microarray	"In SW-620 and HCT-116 colon cancer cells, has-circpedia-5280 (from host gene LRP5) acts as a sponge for miR-4712-5p and modulates AKT/mTOR phosphorylation, thereby inhibiting autophagy and promoting proliferation and migration. hBD-1 treatment decreases has-circpedia-5280 and promotes autophagy, counteracting the effects of has-circpedia-5280 overexpression."	0.7094
40051638	Frontiers in immunology	2025	Hsa_circ_0001756 drives gastric cancer glycolysis by increasing the expression and stability of PGK1 mRNA.	hsa_circ_0001756	circ_0001756 / circ_1756	hsa_circ_HIPK2	HIPK2	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"In gastric cancer, hsa_circ_0001756 is up-regulated and promotes glycolysis and malignant phenotypes (proliferation, migration/invasion) and tumor growth. Mechanistically, it sponges miR-185-3p to increase PGK1 and also binds PTBP1 to enhance PTBP1 cytoplasmic localization and stabilize PGK1 mRNA, jointly elevating PGK1-driven glycolysis; high expression predicts poorer patient prognosis."	0.8913
40055838	Hereditas	2025	Hsa_circ_0006006 is a potential biomarker for prognosis and cisplatin resistance in non-small cell lung cancer.	hsa_circ_0006006	circ_0006006 / circPDK1	hsa_circ_PDK1	PDK1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0006006 is up-regulated in NSCLC and further elevated in cisplatin (DDP)-resistant settings (patients¡¯ serum and A549/DDP cells). Functional assays show that hsa_circ_0006006 promotes DDP resistance by enhancing colony formation/proliferation and modulating apoptosis. Clinically, high hsa_circ_0006006 correlates with poor survival and shows diagnostic potential for NSCLC and DDP resistance."	0.8141
40060410	bioRxiv : the preprint server for biology	2025	Resistance to Radiation Enhances Metastasis by Altering RNA Metabolism.		circRAB12	hsa_circ_RAB12	RAB12	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; RNA-seq	"In radioresistant TNBC cells, circRAB12 is upregulated in an HNRNPL-dependent manner and is predicted to sponge let-7 microRNAs, thereby increasing ITGbeta3 expression/stability and promoting migratory phenotypes."	0.5627
40060410	bioRxiv : the preprint server for biology	2025	Resistance to Radiation Enhances Metastasis by Altering RNA Metabolism.		circBACE2	hsa_circ_BACE2	BACE2	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; RNA-seq	"circBACE2 is an HNRNPL-induced circRNA upregulated in radioresistant TNBC cells; together with other ceRNA circRNAs, it is proposed to sponge let-7 miRNAs to enhance ITGbeta3 mRNA stability and promote migration."	0.5607
40060410	bioRxiv : the preprint server for biology	2025	Resistance to Radiation Enhances Metastasis by Altering RNA Metabolism.		circBIRC6	hsa_circ_BIRC6	BIRC6	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; RNA-seq	"circBIRC6 is upregulated in an HNRNPL-dependent manner in radioresistant TNBC cells and is implicated (with other circRNAs) in let-7 sequestration to stabilize and enhance ITGbeta3 expression, supporting migration."	0.5607
40061128	Frontiers in genetics	2025	Comprehensive analysis of non-coding RNA-mediated endothelial cell-specific regulatory circuits in coronary artery disease risk.		circZNF609 / circular RNA-ZNF609	hsa_circ_ZNF609	ZNF609	coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	unknown	Microarray	"This study links the CAD GWAS variant rs6494488 to circZNF609 and proposes that circZNF609 acts as a ceRNA in endothelial-cell programs by sponging hsa-miR-15a/15b/16 to regulate targets including SPARC and HSPG2, potentially contributing to endothelial dysfunction in CAD."	0.1768
40061128	Frontiers in genetics	2025	Comprehensive analysis of non-coding RNA-mediated endothelial cell-specific regulatory circuits in coronary artery disease risk.		circABCC1	hsa_circ_ABCC1	ABCC1	coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	unknown	Microarray	This study implicates circABCC1 as a CAD-related circRNA potentially affected by variant rs12691049 and proposes that it promotes endothelial dysfunction by modulating miRNAs including hsa-miR-34a/34c and hsa-let-7b/7i.	0.1768
40061128	Frontiers in genetics	2025	Comprehensive analysis of non-coding RNA-mediated endothelial cell-specific regulatory circuits in coronary artery disease risk.		circHERPUD2	hsa_circ_HERPUD2	HERPUD2	coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	unknown	Microarray	"The paper proposes that circHERPUD2 participates in an EC-specific ceRNA circuit in CAD by binding hsa-miR-218 and regulating MARCKS, linking it to endothelial programs such as ECM organization and angiogenesis; it is also mentioned as a potential CAD biomarker."	0.1768
40061587	World journal of gastroenterology	2025	Oxidative stress-induced circSOD2 inhibits osteogenesis through sponging miR-29b in metabolic-associated fatty liver disease.	hsa_circ_0004662	circSOD2	hsa_circ_SOD2	SOD2	metabolic-associated fatty liver disease / MAFLD	MONDO:0013209	metabolic dysfunction-associated steatotic liver disease	up-regulated	RT-qPCR; RNA-seq; Microarray	"circSOD2 (hsa_circ_0004662) is up-regulated in MAFLD liver/primary hepatocytes and can be delivered from hepatocytes to BMSCs. It suppresses osteogenic differentiation and in vivo bone formation by sponging miR-29b, supported by RIP/RAP, luciferase reporter assays, and cytoplasmic co-localization by FISH."	0.7385
40067902	Proceedings of the National Academy of Sciences of the United States of America	2025	p53 activates circASCC3 to repress R-loops and enhance resistance to chemotherapy.	hsa_circ_0077495	circASCC3	hsa_circ_ASCC3	ASCC3	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	"circASCC3 (hsa_circ_0077495), derived from ASCC3, is induced by p53 and mainly localizes in the cytoplasm. It promotes cancer cell survival and chemoresistance under genotoxic stress by binding and stabilizing DDX5, thereby enhancing R-loop resolution; SFPQ negatively regulates its circularization. In colorectal cancer tissues, circASCC3 is lower than in matched normal tissues, while higher tumor levels trend toward worse prognosis."	0.8229
40069492	Acta pharmacologica Sinica	2025	CircSARS-CV2-N1368 from SARS-CoV-2 impairs endothelial cell function through the upregulation of ATF7 to activate TLR4/NF-kappaB/ROS signaling.		circSARS-CV2-N1368		N gene	COVID-19 / coronavirus disease 2019	MONDO:0100096	COVID-19	unknown	RT-qPCR	"circSARS-CV2-N1368 (a SARS-CoV-2 N-gene-derived circRNA) impairs endothelial function by sponging miR-103a-3p, thereby increasing ATF7 and activating the TLR4/NF-kappaB/ROS axis. This leads to elevated ROS and endothelial dysfunction phenotypes including reduced proliferation/migration and suppressed angiogenesis."	0.7953
40069492	Acta pharmacologica Sinica	2025	CircSARS-CV2-N1368 from SARS-CoV-2 impairs endothelial cell function through the upregulation of ATF7 to activate TLR4/NF-kappaB/ROS signaling.		circSARS-CV2-N654		N gene	COVID-19 / coronavirus disease 2019	MONDO:0100096	COVID-19	unknown	RT-qPCR	"circSARS-CV2-N654 is a SARS-CoV-2 N-gene-derived circRNA that, when exogenously overexpressed in endothelial cells, increases platelet adhesion and ROS, and suppresses proliferation/migration and angiogenesis. No specific downstream miRNA/target axis was established for this circRNA in the paper."	0.664
40069492	Acta pharmacologica Sinica	2025	CircSARS-CV2-N1368 from SARS-CoV-2 impairs endothelial cell function through the upregulation of ATF7 to activate TLR4/NF-kappaB/ROS signaling.		circSARS-CV2-N804		N gene	COVID-19 / coronavirus disease 2019	MONDO:0100096	COVID-19	unknown	RT-qPCR	circSARS-CV2-N804 is a SARS-CoV-2 N-gene-derived circRNA that promotes platelet adhesion and inflammatory gene expression in endothelial cells and suppresses endothelial proliferation/migration and angiogenic capacity when overexpressed. The study did not define a specific miRNA/target pathway for circSARS-CV2-N804.	0.664
40069595	BMC gastroenterology	2025	Expression profile and N6-methyadenosine modification of circular RNA analysis in MAFLD.		hsa-MLIP_0004	hsa_circ_MLIP	MLIP	metabolic-associated fatty liver disease / MAFLD	MONDO:0013209	metabolic dysfunction-associated steatotic liver disease	up-regulated	RT-qPCR; Microarray	"hsa-MLIP_0004 is up-regulated in MAFLD liver tissues versus controls and was RT-qPCR-validated. Its m6A methylation level is decreased in MAFLD, and it is predicted to bind m6A reader proteins (e.g., IGF2BP family, HNRNPC, YTHDC1, YTHDF1), suggesting m6A-linked regulation."	0.5135
40069595	BMC gastroenterology	2025	Expression profile and N6-methyadenosine modification of circular RNA analysis in MAFLD.		hsa-CHD2_0084	hsa_circ_CHD2	CHD2	metabolic-associated fatty liver disease / MAFLD	MONDO:0013209	metabolic dysfunction-associated steatotic liver disease	up-regulated	RT-qPCR; Microarray	"hsa-CHD2_0084 is up-regulated in MAFLD liver tissues versus controls and was RT-qPCR-validated. Its m6A methylation level is increased in MAFLD, and it is predicted to bind m6A reader proteins, suggesting m6A-associated regulation in MAFLD."	0.5135
40069595	BMC gastroenterology	2025	Expression profile and N6-methyadenosine modification of circular RNA analysis in MAFLD.	hsa_circ_0008234	hsa-FOXP1_0001	hsa_circ_FOXP1	FOXP1	metabolic-associated fatty liver disease / MAFLD	MONDO:0013209	metabolic dysfunction-associated steatotic liver disease	down-regulated	RT-qPCR; Microarray	"hsa-FOXP1_0001 (hsa_circ_0008234) is down-regulated in MAFLD liver tissues versus controls and was RT-qPCR-validated. Its m6A methylation level is increased in MAFLD, and it is predicted to bind m6A reader proteins, suggesting m6A-associated regulation in MAFLD; its direct mechanistic role in MAFLD was not functionally tested."	0.5135
40070794	Oncology letters	2025	hsa_circ_0004846 enhances the malignant phenotype of papillary thyroid carcinoma cells via the miR_142_3p/PELI1 axis.	hsa_circ_0004846	circ_0004846 / circ_SAMD4A	hsa_circ_SAMD4A	SAMD4A	papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"hsa_circ_0004846 is upregulated in papillary thyroid carcinoma tissues and cell lines and promotes proliferation, migration, and invasion. It functions as a ceRNA by sponging miR-142-3p to increase PELI1 expression, thereby activating PI3K/AKT signaling."	0.7183
40082804	BMC cancer	2025	Pathological expression of mitochondrial genome-derived circRNA SCAR/mc-COX2 and its ceRNA network in colorectal cancer: implications for clinical significance.	hsa_circ_0089762	SCAR / circ_0089762	hsa_circ_COX2	COX2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"SCAR/mc-COX2 (mc-COX2; hsa-circ-0089762) is significantly down-regulated in CRC tumor tissues and is suggested to act as a tumor suppressor and potential diagnostic biomarker (AUC=0.77). The study predicts a SCAR/mc-COX2-centered ceRNA network involving five miRNAs (including hsa-miR-938 and hsa-miR-1249) and multiple target mRNAs (e.g., MGLL, FAM107A, PLCG2), and also predicts interactions with several RBPs."	0.459
40082884	Cancer cell international	2025	Exploring the potential mechanisms of sorafenib resistance in hepatocellular carcinoma cell lines based on RNA sequencing.		circ_SPECC1	hsa_circ_SPECC1	SPECC1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RNA-seq	circ_SPECC1 was identified by RNA-seq/network analysis as up-regulated in sorafenib-resistant HCC cell lines and was proposed to contribute to resistance by interacting with hsa-let-7c-5p and influencing CDK1/PLK1 (cell cycle) and IL13RA1 (JAK-STAT signaling).	0.1768
40083243	RNA biology	2025	Circular RNA Circ_0002762 promotes cell migration and invasion in cervical squamous cell carcinoma via activating RelA/nuclear factor kappa B (Nf-kB) signalling pathway.	hsa_circ_0002762	circ_0002762	hsa_circ_CDK17	CDK17	cervical squamous cell carcinoma / CSCC	MONDO:0006143	cervical squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0002762 is up-regulated in CSCC and promotes cell migration and invasion (and proliferation). Mechanistically, FOXA1 transcriptionally activates circ_0002762, which recruits MOV10 to enhance RelA mRNA stability and activate NF-kappaB signaling."	0.7986
40083276	ACS infectious diseases	2025	Plasmodium Infection Modulates Host Inflammatory Response through circRNAs during the Intracellular Stage in Red Blood Cells.		novel_circ_0004590 / circRNA4590			malaria	MONDO:0005136	malaria	up-regulated	RT-qPCR; RNA-seq	"novel_circ_0004590 is up-regulated in spleens of P.y17XL-infected BALB/c mice. It is suggested to have IRES-associated protein-coding potential, and the encoded proteins may participate in the host inflammatory response during malaria infection."	0.5922
40083276	ACS infectious diseases	2025	Plasmodium Infection Modulates Host Inflammatory Response through circRNAs during the Intracellular Stage in Red Blood Cells.		novel_circ_0003481			malaria	MONDO:0005136	malaria	up-regulated	RT-qPCR; RNA-seq	novel_circ_0003481 is significantly up-regulated in spleen tissue of P.y17XL-infected BALB/c mice. The paper does not provide a specific downstream mechanism for this circRNA.	0.5922
40083276	ACS infectious diseases	2025	Plasmodium Infection Modulates Host Inflammatory Response through circRNAs during the Intracellular Stage in Red Blood Cells.		novel_circ_0005252			malaria	MONDO:0005136	malaria	up-regulated	RT-qPCR; RNA-seq	novel_circ_0005252 is significantly up-regulated in spleen tissue of P.y17XL-infected BALB/c mice. The paper does not provide a specific downstream mechanism for this circRNA.	0.5922
40083276	ACS infectious diseases	2025	Plasmodium Infection Modulates Host Inflammatory Response through circRNAs during the Intracellular Stage in Red Blood Cells.		novel_circ_0003964			malaria	MONDO:0005136	malaria	up-regulated	RT-qPCR; RNA-seq	novel_circ_0003964 is up-regulated in spleens of P.y17XL-infected BALB/c mice. The study suggests it may contribute to parasite_host communication and is among circRNAs predicted to have protein-coding potential relevant to malaria immune responses.	0.5922
40083276	ACS infectious diseases	2025	Plasmodium Infection Modulates Host Inflammatory Response through circRNAs during the Intracellular Stage in Red Blood Cells.		novel_circ_0002787			malaria	MONDO:0005136	malaria	up-regulated	RT-qPCR; RNA-seq	novel_circ_0002787 is significantly up-regulated in spleen tissue of P.y17XL-infected BALB/c mice. The paper does not specify a dedicated mechanistic axis for this circRNA.	0.5922
40083276	ACS infectious diseases	2025	Plasmodium Infection Modulates Host Inflammatory Response through circRNAs during the Intracellular Stage in Red Blood Cells.	mmu_circ_0000604				malaria	MONDO:0005136	malaria	up-regulated	RT-qPCR; RNA-seq	mmu_circ_0000604 is significantly up-regulated in spleen tissue of P.y17XL-infected BALB/c mice. The study does not report a specific mechanistic pathway for this circRNA.	0.5922
40083276	ACS infectious diseases	2025	Plasmodium Infection Modulates Host Inflammatory Response through circRNAs during the Intracellular Stage in Red Blood Cells.	mmu_circ_0001829				malaria	MONDO:0005136	malaria	down-regulated	RT-qPCR; RNA-seq	mmu_circ_0001829 is significantly down-regulated in spleen tissue of P.y17XL-infected BALB/c mice. It is discussed as one of the differentially expressed circRNAs with suggested protein-coding potential that may be relevant to malaria immune responses.	0.5922
40083276	ACS infectious diseases	2025	Plasmodium Infection Modulates Host Inflammatory Response through circRNAs during the Intracellular Stage in Red Blood Cells.	mmu_circ_0000894				malaria	MONDO:0005136	malaria	down-regulated	RT-qPCR; RNA-seq	"mmu_circ_0000894 is significantly down-regulated in spleen tissue during P.y17XL malaria infection in BALB/c mice. Enrichment analyses highlight it among main circRNAs associated with inflammation-related pathways (including MAPK), and it is also discussed as potentially protein-coding and relevant to malaria immune responses."	0.5922
40083276	ACS infectious diseases	2025	Plasmodium Infection Modulates Host Inflammatory Response through circRNAs during the Intracellular Stage in Red Blood Cells.	mmu_circ_0000271	novel_circ_0000271			malaria	MONDO:0005136	malaria	down-regulated	RT-qPCR; RNA-seq	mmu_circ_0000271 (also referred to as novel_circ_0000271 in the discussion) is significantly down-regulated in spleen tissue of P.y17XL-infected BALB/c mice. No specific mechanism is provided for this circRNA in the main text.	0.5922
40083276	ACS infectious diseases	2025	Plasmodium Infection Modulates Host Inflammatory Response through circRNAs during the Intracellular Stage in Red Blood Cells.		novel_circ_0006040			malaria	MONDO:0005136	malaria	down-regulated	RT-qPCR; RNA-seq	"novel_circ_0006040 is significantly down-regulated in spleen tissue during P.y17XL malaria infection in BALB/c mice. Enrichment analyses highlight it among the main circRNAs linked to inflammation-related pathways including MAPK, and it is discussed as a potentially protein-coding circRNA relevant to malaria immune responses."	0.5922
40083276	ACS infectious diseases	2025	Plasmodium Infection Modulates Host Inflammatory Response through circRNAs during the Intracellular Stage in Red Blood Cells.	mmu_circ_0001031				malaria	MONDO:0005136	malaria	down-regulated	RT-qPCR; RNA-seq	"mmu_circ_0001031 is significantly down-regulated in spleen tissue of P.y17XL-infected BALB/c mice. It is discussed as a differentially expressed circRNA with suggested protein-coding potential and possible relevance to malaria immune responses, but no specific axis is established."	0.5922
40084746	"Cancer communications (London, England)"	2025	Blocking ITGA5 potentiates the efficacy of anti-PD-1 therapy on glioblastoma by remodeling tumor-associated macrophages.	hsa_circ_0000311	circSDHAF2 / circular RNA succinate dehydrogenase complex assembly factor 2	hsa_circ_SDHAF2	SDHAF2	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR	"In glioblastoma, circSDHAF2 is upregulated in mesenchymal GSCs and promotes MES-GBM state and tumorigenesis. It binds ITGA5 and enhances B4GALT1-mediated N-glycosylation to stabilize ITGA5 and facilitate ITGA5 loading into exosomes, which drives SPP1+ macrophage polarization and subsequent T-cell dysfunction via the SPP1_ITGA5 axis, contributing to immune escape and anti-PD-1 resistance."	0.8405
40087716	Hereditas	2025	CircCENPM serves as a CeRNA to aggravate nasopharyngeal carcinoma metastasis and stemness via enhancing BMI1.	hsa_circ_0063626	CircCENPM / circ_CENPM	hsa_circ_CENPM	CENPM	nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; RNA-seq	"circCENPM is up-regulated in nasopharyngeal carcinoma and mainly localized in the cytoplasm. It promotes NPC proliferation, migration/metastasis, stemness and tumor growth, partly by acting as a ceRNA for miR-362-3p to increase BMI1 expression; high circCENPM is associated with worse patient survival."	0.795
40089857	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2025	Homocysteine Promotes the Pathogenesis of Atherosclerosis through the Circ-PIAS1-5/miR-219a-2-3p/TEAD1 Axis.		circ_PIAS1_5	hsa_circ_PIAS1	PIAS1	atherosclerosis / AS	MONDO:0005311	atherosclerosis	down-regulated	RT-qPCR; RNA-seq	"circ-PIAS1-5 is down-regulated by homocysteine in foam cells and HHcy-associated atherosclerosis and suppresses lipid accumulation and plaque formation. It functions as a ceRNA by sponging miR-219a-2-3p to upregulate TEAD1 and modulate AMPK signaling, while Hcy-driven m6A modification enables YTHDC1-dependent nucleo-cytoplasmic trafficking that impacts its sponge activity. Circulating/blood circ-PIAS1-5 shows potential diagnostic value for HHcy-associated atherosclerosis."	0.887
40089857	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2025	Homocysteine Promotes the Pathogenesis of Atherosclerosis through the Circ-PIAS1-5/miR-219a-2-3p/TEAD1 Axis.		circ_PIAS1_5	mmu_circ_PIAS1	PIAS1	atherosclerosis / AS	MONDO:0005311	atherosclerosis	down-regulated	RT-qPCR; RNA-seq	"circ-PIAS1-5 is down-regulated by homocysteine in foam cells and HHcy-associated atherosclerosis and suppresses lipid accumulation and plaque formation. It functions as a ceRNA by sponging miR-219a-2-3p to upregulate TEAD1 and modulate AMPK signaling, while Hcy-driven m6A modification enables YTHDC1-dependent nucleo-cytoplasmic trafficking that impacts its sponge activity. Circulating/blood circ-PIAS1-5 shows potential diagnostic value for HHcy-associated atherosclerosis."	0.887
40091031	BMC musculoskeletal disorders	2025	Teriparatide facilitates osteogenic differentiation of bone mesenchymal stem cells to alleviate idiopathic osteoporosis via the circFNDC3B-miR-125a-5p-GLS axis.		Circular RNA FNDC3B / circFNDC3B	hsa_circ_FNDC3B	FNDC3B	Osteoporosis / OP	MONDO:0005298	osteoporosis	down-regulated	RT-qPCR	"In primary hMSCs from osteoporosis patients, circFNDC3B is down-regulated. circFNDC3B promotes teriparatide-induced osteogenic differentiation by sponging miR-125a-5p, thereby relieving inhibition of GLS and supporting glutamine metabolism required for osteogenesis."	0.6947
40091520	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2025	ADAR1-HNRNPL-Mediated CircCANX Decline Promotes Autophagy in Chronic Obstructive Pulmonary Disease.	hsa_circ_0001564	circCANX	hsa_circ_CANX	CANX	Chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	down-regulated	RT-qPCR; RNA-seq	"CircCANX is down-regulated in COPD blood and CSE-treated airway epithelial cells and is mainly nuclear. It acts as a nuclear scaffold to assemble P53 mRNA with UPF1, promoting NMD-dependent P53 mRNA decay, thereby suppressing autophagy/SG formation and enhancing inflammatory cytokine production; in CS-exposed mice, circCANX exacerbates lung injury and inflammation."	0.8811
40093675	World journal of gastroenterology	2025	Circular RNA contributes to gastric cancer by targeting Wnt family member 2B as a competing endogenous RNA.		hsa_circRNA_102415 / hsa_cirRNA_102415			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_102415 is up-regulated in gastric cancer tissues/cell lines and promotes malignant phenotypes (proliferation, invasion, cell-cycle progression) while inhibiting apoptosis. Mechanistically, it functions as a ceRNA that sponges miR-4529-5p to increase WNT2B expression, and higher expression is associated with worse survival in the studied cohort."	0.7941
40093898	Theranostics	2025	Microglial circDlg1 modulates neuroinflammation by blocking PDE4B ubiquitination-dependent degradation associated with Alzheimer's disease.	hsa_circ_0123248		hsa_circ_DLG1	Dlg1	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR; ISH; Microarray	"circDlg1 is up-regulated in AD microglia (APP/PS1 mice and human AD cortex). It binds PDE4B and Smurf2 to protect PDE4B from ubiquitination-dependent degradation, lowering cAMP and suppressing PKA/CREB anti-inflammatory signaling, thereby promoting neuroinflammation. Microglia-specific circDlg1 knockdown enhances Abeta engagement/uptake, reduces neuroinflammation and Abeta burden, and improves cognition in APP/PS1 mice."	0.7958
40093898	Theranostics	2025	Microglial circDlg1 modulates neuroinflammation by blocking PDE4B ubiquitination-dependent degradation associated with Alzheimer's disease.	mmu_circ_0000679		mmu_circ_Dlg1	Dlg1	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR; ISH; Microarray	"circDlg1 is up-regulated in AD microglia (APP/PS1 mice and human AD cortex). It binds PDE4B and Smurf2 to protect PDE4B from ubiquitination-dependent degradation, lowering cAMP and suppressing PKA/CREB anti-inflammatory signaling, thereby promoting neuroinflammation. Microglia-specific circDlg1 knockdown enhances Abeta engagement/uptake, reduces neuroinflammation and Abeta burden, and improves cognition in APP/PS1 mice."	0.7958
40093901	Theranostics	2025	Circular RNA CHACR is involved in the pathogenesis of cardiac hypertrophy.	hsa_circ_0001083	cardiac hypertrophy-associated circRNA (CHACR) / CHACR	hsa_circ_Pms1	Pms1	cardiac hypertrophy	MONDO:0005045	hypertrophic cardiomyopathy	down-regulated	RT-qPCR; RNA-seq	"CHACR is down-regulated in TAC-induced cardiac hypertrophy and acts as an anti-hypertrophic circRNA. It binds CPT1b and reduces its ubiquitin_proteasome degradation, increasing CPT1b protein levels and suppressing Jak2/Stat3 signaling (via lowering L-carnitine), thereby attenuating cardiomyocyte hypertrophy in vitro and in vivo."	0.8044
40093901	Theranostics	2025	Circular RNA CHACR is involved in the pathogenesis of cardiac hypertrophy.		cardiac hypertrophy-associated circRNA (CHACR) / CHACR	mmu_circ_Pms1	Pms1	cardiac hypertrophy	MONDO:0005045	hypertrophic cardiomyopathy	down-regulated	RT-qPCR; RNA-seq	"CHACR is down-regulated in TAC-induced cardiac hypertrophy and acts as an anti-hypertrophic circRNA. It binds CPT1b and reduces its ubiquitin_proteasome degradation, increasing CPT1b protein levels and suppressing Jak2/Stat3 signaling (via lowering L-carnitine), thereby attenuating cardiomyocyte hypertrophy in vitro and in vivo."	0.8044
40098195	Molecular cancer	2025	o8G-modified circPLCE1 inhibits lung cancer progression via chaperone-mediated autophagy.	hsa_circ_0019225	circPLCE1	hsa_circ_PLCE1	PLCE1	lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR; RNA-seq	"circPLCE1 is down-regulated in lung cancer and functions as a tumor suppressor. ROS-induced o8G modification recruits AUF1 to reduce circPLCE1 stability, while circPLCE1 binds HSC70 to enhance its ubiquitination, inhibit CMA, and promote ATG5-dependent macroautophagy, thereby suppressing lung cancer progression."	0.8994
40099939	Journal of cellular and molecular medicine	2025	Circular RNA circHSPA8 Aggravates Metastasis by Acting as a Competitive Inhibitor of miR-195-5p to Upregulate WNT3A Expression in Breast Cancer.	hsa_circ_0024715	Circ_hsa_0024715 / circHSPA8	hsa_circ_HSPA8	HSPA8	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq; Microarray	"circHSPA8 (hsa_circ_0024715), derived from HSPA8, is up-regulated in breast cancer tissues and cell lines and is associated with lymph node metastasis and poorer survival. Functionally, it promotes proliferation, invasion/migration, EMT, and lung metastasis by sponging miR-195-5p and thereby upregulating WNT3A (activating WNT/beta-catenin-related EMT programs)."	0.8815
40099942	Journal of cellular and molecular medicine	2025	Hsa_circ_0004662 Accelerates the Progression of Ulcerative Colitis via the microRNA-532/HMGB3 Signalling Axis.	hsa_circ_0004662	circ_0004662 / circ0004662			ulcerative colitis / UC	MONDO:0005101	ulcerative colitis	up-regulated	RT-qPCR	"hsa_circ_0004662 is upregulated in ulcerative colitis tissues and promotes UC-associated epithelial injury and inflammation. It primarily localizes to the cytoplasm and functions as a ceRNA by sponging miR-532, thereby relieving miR-532-mediated repression of HMGB3. Knockdown of circ_0004662 increases miR-532, decreases HMGB3, attenuates inflammatory cytokine release and tissue damage in DSS-induced colitis, and reduces apoptosis markers in vitro and in vivo."	0.7421
40100806	PLoS genetics	2025	MEOX1-mediated transcriptional regulation of circABHD3 exacerbates hepatic fibrosis through promoting m6A/YTHDF2-dependent YPEL3 mRNA decay to activate beta-catenin signaling.	hsa_circ_0047086	circABHD3 / circAHBD3	hsa_circ_ABHD3	ABHD3	hepatic fibrosis / HF	MONDO:0005155	cirrhosis of liver	up-regulated	RT-qPCR	"circABHD3 is up-regulated in hepatic fibrosis patient tissues and fibrosis models, and promotes hepatocyte EMT and mitochondrial impairment, thereby exacerbating liver fibrosis. Mechanistically, it binds YTHDF2 to enhance YTHDF2-dependent decay of m6A-modified YPEL3 mRNA, activating Wnt/beta-catenin signaling; its biogenesis is promoted by MEOX1 via ABHD3 promoter binding."	0.8515
40114244	Journal of experimental & clinical cancer research : CR	2025	CircPVT1 weakens miR-33a-5p unleashing the c-MYC/GLS1 metabolic axis in breast cancer.		circPVT1	hsa_circ_PVT1	PVT1	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"circPVT1 is up-regulated in breast cancer tissues and promotes oncogenic phenotypes and metabolic reprogramming. It predominantly localizes in the cytoplasm and sponges miR-33a-5p (also miR-145-5p and miR-203), thereby increasing c-MYC activity and transcriptional upregulation of GLS1 to enhance glutaminolysis and support tumor progression; circPVT1 depletion sensitizes cells and TNBC patient-derived organoids to GLS1 inhibitors."	0.8554
40125274	Molecular therapy. Nucleic acids	2025	Whole-transcriptome sequencing in neural and non-neural tissues of a mouse model identifies miR-34a as a key regulator in SMA pathogenesis.		circRNA007386	mmu_circ_RyR2	RyR2	spinal muscular atrophy / SMA	MONDO:0001516	spinal muscular atrophy	down-regulated	RT-qPCR; RNA-seq	circRNA007386 is a RyR2-derived circRNA that is down-regulated in SMA mouse heart (P1 and P4) and participates in a miR-34a-5p-centered ceRNA network. It directly contains miR-34a-5p MREs and is included in an axis linked to regulation of Spag5 and cardiac cell-cycle arrest phenotypes.	0.6912
40125274	Molecular therapy. Nucleic acids	2025	Whole-transcriptome sequencing in neural and non-neural tissues of a mouse model identifies miR-34a as a key regulator in SMA pathogenesis.		circRNA014460			spinal muscular atrophy / SMA	MONDO:0001516	spinal muscular atrophy	down-regulated	RT-qPCR; RNA-seq	"circRNA014460 is down-regulated in SMA mouse heart (P1 and P4) and decreases upon miR-34a-5p overexpression in C2C12 cells, supporting its inclusion among putative miR-34a-5p-associated ceRNAs. No direct binding site validation or downstream functional mechanism was reported for this circRNA."	0.3588
40128740	Molecular cancer	2025	Circular RNA circDCUN1D4 suppresses hepatocellular carcinoma development via targeting the miR-590-5p/ TIMP3 axis.	hsa_circ_0007928	circDCUN1D4	hsa_circ_DCUN1D4	DCUN1D4	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"circDCUN1D4 is down-regulated in HCC and acts as a tumor suppressor by inhibiting proliferation, migration/invasion and promoting apoptosis. It mainly localizes to the cytoplasm and functions as a ceRNA that sponges miR-590-5p to regulate TIMP3, affecting metastasis-related proteins (e.g., MMP9, E-cadherin, Vimentin). Higher circDCUN1D4 expression is associated with better patient survival and circDCUN1D4 delivery suppresses xenograft growth in mice."	0.8847
40130381	Cancer medicine	2025	circTUBD1-hnRNPK Regulates the Proliferation and Migration of LSCC by Targeting CCAR1.	hsa_circ_0044894	circTUBD1 / hsa_circ_004489	hsa_circ_TUBD1	TUBD1	laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circTUBD1 (hsa_circ_0044894), derived from TUBD1, is upregulated in LSCC tissues and cell lines and acts as an oncogenic circRNA that promotes proliferation, migration/invasion and EMT-like changes. Mechanistically, circTUBD1 binds hnRNPK to form a circRNA-protein complex and increases CCAR1 expression, driving LSCC progression; silencing circTUBD1 suppresses tumor growth and metastasis in vivo."	0.8717
40130394	Annals of medicine	2025	circKCNQ5 promotes the proliferation of DNA-methyltransferase 3A R882 mutated acute myeloid leukemia cells by elevating high-mobility group box 1 expression.	hsa_circ_0004136	circKCNQ5 / circ_KCNQ5	hsa_circ_KCNQ5	KCNQ5	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; Microarray	"circKCNQ5 is up-regulated in DNMT3A-WT and especially DNMT3A R882-mutant AML cell models. It promotes AML cell proliferation and G1-to-S progression by binding HMGB1, inhibiting its ubiquitination, and increasing HMGB1 protein levels."	0.721
40131148	JACC. Basic to translational science	2025	CircBTBD7-420aa Encoded by hsa_circ_0000563 Regulates the Progression of Atherosclerosis and Construction of circBTBD7-420aa Engineered Exosomes.	hsa_circ_0000563	circBTBD7	hsa_circ_BTBD7	BTBD7	coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	down-regulated	RT-qPCR	"hsa_circ_0000563 (circBTBD7) is down-regulated in an ox-LDL_induced HCASMC abnormal proliferation/migration model and functions mainly by encoding circBTBD7-420aa. The encoded protein promotes ubiquitin-proteasome degradation of SLC3A2, thereby inhibiting HCASMC proliferation/migration and suppressing atherosclerosis progression in vivo."	0.6888
40133811	BMC cardiovascular disorders	2025	"Molecular epidemiological study of exosomes circZNF609, circPUM1, IGF2 with ischemic stroke."		circZNF609	hsa_circ_ZNF609	ZNF609	ischemic stroke / IS	MONDO:1060198	ischemic stroke	unknown	RT-qPCR	"This cross-sectional case_control study measured plasma exosomal circZNF609 by RT-qPCR and evaluated its association with ischemic stroke risk. Although overall case_control expression differences were not significant, adjusted regression analyses linked higher circZNF609 quartiles with reduced IS risk, supporting its potential as an exosomal biomarker."	0.459
40134002	Journal of orthopaedic surgery and research	2025	METTL3-mediated m6A modification of circSTAT6 modulates miR-188-3p/Beclin1 axis to promote osteogenic differentiation of mesenchymal stem cells.	hsa_circ_0027120	circSTAT6	hsa_circ_STAT6	STAT6	osteoporosis / OP	MONDO:0005298	osteoporosis	down-regulated	RT-qPCR; RNA-seq	"circSTAT6 is down-regulated in osteoporosis trabecular bone tissue. m6A writer METTL3 increases circSTAT6 m6A level and expression, and circSTAT6 promotes BMSC proliferation and osteogenic differentiation by sponging miR-188-3p to de-repress Beclin1."	0.8271
40145792	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2025	Therapeutic Delivery of circDYM by Perillyl Alcohol Nanoemulsion Alleviates LPS-Induced Depressive-Like Behaviors.		circDYM	mmu_circ_DYM		major depressive disorder / MDD	MONDO:0002009	major depressive disorder	down-regulated	RT-qPCR	"circDYM is down-regulated in the brains of LPS-induced depressive mice. Intranasal delivery of circDYM via the PANE2-4 nanoemulsion restores circDYM levels and alleviates depressive-like behaviors, associated with reduced microglia activation/iNOS and improved synaptic protein expression (PSD-95 and synaptophysin)."	0.4236
40145839	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2025	A Novel Protein NAB1-356 Encoded by circRNA circNAB1 Mitigates Atrial Fibrillation by Reducing Inflammation and Fibrosis.		circNAB1	hsa_circ_NAB1	NAB1	atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	down-regulated	RT-qPCR; RNA-seq	"circNAB1 is down-regulated in human atrial fibrillation and acts protectively by suppressing atrial fibrosis and inflammatory cytokine expression. It exerts these effects largely via translation into NAB1-356, which interacts with EGR1 and represses transcription of Runx1 and Gadd45b, reducing AF susceptibility and cardiac remodeling in mouse models."	0.8454
40145872	Epigenetics	2025	CircMYH9 promotes the mRNA stability of SPAG6 by recruiting EIF4A3 to facilitate the progression of breast cancer.	hsa_circ_0092283	CircMYH9	hsa_circ_MYH9	MYH9	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"CircMYH9 is up-regulated in breast cancer and promotes malignant phenotypes (proliferation, migration, invasion) and tumor growth. It recruits the RBP EIF4A3 to enhance SPAG6 mRNA stability/expression, which in turn suppresses PTEN and activates the PI3K/AKT pathway, associating high circMYH9 with poor prognosis."	0.7892
40146281	Cellular and molecular life sciences : CMLS	2025	METTL3-dependent m6A methylation of circCEACAM5 fuels pancreatic cancer progression through DKC1 activation.		circCEACAM5	hsa_circ_CEACAM5	CEACAM5	pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"circCEACAM5 is up-regulated in pancreatic cancer tissues/cell lines and promotes proliferation, migration, invasion and tumor growth while inhibiting apoptosis. Mechanistically, METTL3 installs m6A on circCEACAM5 to increase its level, and circCEACAM5 binds the RBP DKC1 to elevate DKC1 expression, contributing to malignant progression and poor clinical outcomes."	0.8748
40148434	Scientific reports	2025	Study on the mechanism of hsa_circ_0074763 regulating the miR-3667-3P/ACSL4 axis in liver fibrosis.	hsa_circ_0074763	circ_0074763 / hsa_circRNA_0074763	hsa_circ_CYFIP2	CYFIP2	liver fibrosis	MONDO:0005155	cirrhosis of liver	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0074763 is up-regulated in liver fibrosis models and promotes HSC activation by acting as a ceRNA that sponges miR-3667-3p, thereby relieving repression of ACSL4. Functionally, it increases LX-2 proliferation and inflammatory markers and reduces apoptosis, linking the axis to ferroptosis-associated readouts."	0.7548
40149664	Biomedicines	2025	Astilbin Alleviates Radiation-Induced Pulmonary Fibrosis via circPRKCE Targeting the TGF-beta/Smad7 Pathway to Inhibit Epithelial-Mesenchymal Transition.	mmu_circ_0000831	mmu-circ-0000831 / circPRKCE	mmu_circ_PRKCE	PRKCE	radiation-induced pulmonary fibrosis / RIPF	MONDO:0043459	radiation-induced disorder	down-regulated	RT-qPCR; RNA-seq	"In RIPF models, circPRKCE is decreased by irradiation and is restored/upregulated by astilbin. circPRKCE acts mainly in the cytoplasm as a ceRNA that sponges miR-15b-5p, thereby increasing Smad7 and suppressing TGF-beta/SMAD-driven EMT and fibrosis; circPRKCE knockdown abolishes astilbin¡¯s protective effects."	0.8265
40152619	mBio	2025	"Functional characterization of a novel protein-coding circular RNA, circRNA_1193, from the mAAP gene in silkworm and its role in antiviral defense against BmCPV."		circRNA_1193	bmo_circ_mAAP	mAAP	Bombyx mori cytoplasmic polyhedrosis virus (BmCPV) infection	MONDO:0005108	viral infectious disease	up-regulated	RT-qPCR; Northern Blot; ISH	circRNA_1193 (from the silkworm mAAP gene) is induced by BmCPV infection and suppresses BmCPV replication in BmN cells. Its antiviral activity depends on translation of an ORF within the circRNA that produces a ~35 kDa protein (VSP35); a proposed additional mechanism is regulation of the miR-277-5p/zinc finger 729 axis.	0.7049
40155591	Cell death & disease	2025	CSF3R-AS promotes hepatocellular carcinoma progression and sorafenib resistance through the CSF3R/JAK2/STAT3 positive feedback loop.	hsa_circ_0000055	CSF3R-AS	hsa_circ_CSF3R	CSF3R	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"CSF3R-AS (hsa_circ_0000055) is up-regulated in HCC and predicts worse overall survival. It promotes HCC proliferation, invasion/metastasis and angiogenesis while inhibiting apoptosis, and contributes to sorafenib resistance. Mechanistically, CSF3R-AS binds CSF3R mRNA and recruits RBMS3 to stabilize CSF3R, activating JAK2/STAT3; STAT3 in turn transcriptionally upregulates CSF3R-AS, forming a positive feedback loop."	0.8913
40155933	Cancer cell international	2025	CircITGA7 overexpression suppresses HCC progression via miR-330/BCL11B axis regulation.	hsa_circ_0026782	circITGA7	hsa_circ_ITGA7	ITGA7	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"circITGA7 is down-regulated in HCC tissues and cell lines and functions as a tumor suppressor. It sponges miR-330, thereby de-repressing BCL11B and increasing P53 expression, which leads to G1 arrest and apoptosis and suppresses proliferation/migration/invasion and xenograft growth."	0.7701
40157540	The Journal of biological chemistry	2025	Circular RNA circ_0004470 accelerates the occurrence of lung cancer by promoting DNA damage and cell cycle arrest.	hsa_circ_0004470	circ_0004470	hsa_circ_MYH9	MYH9	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; RNA-seq	"circ_0004470 (hsa_circ_0004470), derived from MYH9, is upregulated in lung cancer-related cells, animal carcinogen models, and patient tissues/blood. It promotes DNA damage accumulation and S-phase arrest and inhibits DNA repair by binding XPC (reducing XPC mRNA stability and disrupting XPC_hHR23B) and by interacting with DDB1 to drive proteasomal DDB1 degradation and CDT1 dysregulation, thereby promoting malignant transformation and tumor progression."	0.8861
40158127	Cellular & molecular biology letters	2025	CircNF1 modulates the progression and immune evasion of esophageal squamous cell carcinoma through dual regulation of PD-L1.	hsa_circ_0042881	circ_0042881 / circNF1	hsa_circ_NF1	NF1	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circNF1 is upregulated in ESCC tissues and serum and promotes ESCC proliferation, migration/invasion, and immune escape. It increases PD-L1 by activating the IL-6/JAK_STAT3 pathway to enhance PD-L1 transcription and by binding ANXA1 to favor USP7-mediated PD-L1 deubiquitination, stabilizing PD-L1 and reducing CD8+ T-cell antitumor activity. Clinically, higher circNF1 is associated with poorer response to anti-PD-L1 therapy and worse overall survival."	0.8991
40170133	Journal of translational medicine	2025	CircPRKCA facilitates esophageal squamous cell carcinoma metastasis via m5C-dependent CSF2 mRNA stabilization.	hsa_circ_0007580	circPRKCA	hsa_circ_PRKCA	PRKCA	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; ISH	"circPRKCA (hsa_circ_0007580) is up-regulated in ESCC and associated with poor overall survival. It promotes ESCC migration/invasion, angiogenesis, and lung metastasis. Mechanistically, circPRKCA binds YBX1 in the cytoplasm to inhibit its ubiquitin_proteasome degradation, thereby increasing YBX1 and enhancing m5C-dependent stabilization of CSF2 mRNA."	0.8913
40171669	Stroke	2025	Small Extracellular Vesicles From Hypoxia-Neuron Maintain Blood-Brain Barrier Integrity.		CircOGDH	hsa_circ_OGDH		ischemic stroke / IS	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR	"CircOGDH is reduced in plasma of AIS patients with hemorrhagic transformation and negatively correlates with hematoma volume, suggesting a protective association with BBB integrity. Mechanistically, hypoxic neurons package and deliver CircOGDH via small extracellular vesicles to brain endothelial cells, where CircOGDH increases COL4A4 and helps preserve tight junction proteins, endothelial survival, migration, and barrier integrity after hypoxia/reoxygenation and in MCAO/R models."	0.6915
40176113	Journal of experimental & clinical cancer research : CR	2025	o8G-modified circKIAA1797 promotes lung cancer development by inhibiting cuproptosis.	hsa_circ_0003295	circKIAA1797	hsa_circ_KIAA1797	KIAA1797	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; RNA-seq	"In lung cancer, circKIAA1797 (hsa_circ_0003295) is up-regulated and mainly localized in the cytoplasm. It promotes tumor cell viability, proliferation and migration while inhibiting apoptosis, and it suppresses cuproptosis by destabilizing FDX1 mRNA, inhibiting STAT1-driven LIPT1 transcription, and promoting mPTP closure; YBX1 acts as an o8G reader that increases circKIAA1797 stability and cytoplasmic abundance."	0.8988
40176374	Cancer biology & therapy	2025	CircATP5C1 promotes triple-negative breast cancer progression by binding IGF2BP2 to modulate CSF-1 secretion.	hsa_circ_0007292	circATP5C1	hsa_circ_ATP5C1	ATP5C1	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circATP5C1 is up-regulated in breast cancer/TNBC and its high level predicts worse survival. Functionally, circATP5C1 promotes TNBC proliferation, migration, invasion, EMT and tumor growth by binding IGF2BP2 to enhance m6A-associated CSF-1 mRNA stability and CSF-1 secretion."	0.8973
40181128	Scientific reports	2025	Exploring the diagnostic potential of plasma circ-CCDC66 in colorectal cancer.	hsa_circ_0001313	circ-CCDC66 / circCCDC66	hsa_circ_CCDC66	CCDC66	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"Plasma circ-CCDC66 is up-regulated in colorectal polyps and colorectal cancer and shows strong diagnostic performance (AUC 0.920), further improved when combined with CEA and CA19-9. Bioinformatics analyses construct a circ-CCDC66_miRNA_mRNA (ceRNA) network suggesting potential involvement in CRC-related pathways and processes."	0.5047
40188043	BMC pulmonary medicine	2025	Genome-wide analysis of m6A-modified circRNAs in the mouse model of myocardial injury induced by obstructive sleep apnea.		mmu_circRNAs_011180			obstructive sleep apnea / OSA	MONDO:0007147	obstructive sleep apnea syndrome	up-regulated	RT-qPCR; Microarray	"mmu_circRNAs_011180 is an m6A-modified circRNA up-regulated in left ventricular tissue of CIH (OSA model) mice, with expression change validated by MeRIP-qPCR consistent with microarray results. No specific miRNA/mRNA targets or functional assays were reported for this circRNA."	0.5803
40188043	BMC pulmonary medicine	2025	Genome-wide analysis of m6A-modified circRNAs in the mouse model of myocardial injury induced by obstructive sleep apnea.		mmu_circRNAs_014597			obstructive sleep apnea / OSA	MONDO:0007147	obstructive sleep apnea syndrome	up-regulated	RT-qPCR; Microarray	"mmu_circRNAs_014597 is an m6A-modified circRNA up-regulated in left ventricular tissue in the CIH (OSA) mouse model, validated by MeRIP-qPCR consistent with microarray. The paper does not report its downstream targets or functional roles beyond differential expression/m6A enrichment profiling."	0.5803
40188043	BMC pulmonary medicine	2025	Genome-wide analysis of m6A-modified circRNAs in the mouse model of myocardial injury induced by obstructive sleep apnea.		mmu_circRNAs_008397			obstructive sleep apnea / OSA	MONDO:0007147	obstructive sleep apnea syndrome	up-regulated	RT-qPCR; Microarray	"mmu_circRNAs_008397 is an m6A-modified circRNA up-regulated in the CIH (OSA) mouse left ventricle, validated by MeRIP-qPCR in agreement with microarray profiling. The study does not provide a specific ceRNA network or downstream targets for this circRNA."	0.5803
40188043	BMC pulmonary medicine	2025	Genome-wide analysis of m6A-modified circRNAs in the mouse model of myocardial injury induced by obstructive sleep apnea.		mmu_circRNAs_34841			obstructive sleep apnea / OSA	MONDO:0007147	obstructive sleep apnea syndrome	down-regulated	RT-qPCR; Microarray	"mmu_circRNAs_34841 is an m6A-modified circRNA down-regulated in CIH (OSA) mouse left ventricular tissue, validated by MeRIP-qPCR consistent with microarray. It was included among three circRNAs selected for a computationally predicted ceRNA (circRNA-miRNA-mRNA) network, but specific miRNAs/mRNAs for this circRNA were not detailed in the provided text."	0.5803
40188043	BMC pulmonary medicine	2025	Genome-wide analysis of m6A-modified circRNAs in the mouse model of myocardial injury induced by obstructive sleep apnea.		mmu_circRNAs_22543 / mmu_circRNA_22543			obstructive sleep apnea / OSA	MONDO:0007147	obstructive sleep apnea syndrome	down-regulated	RT-qPCR; Microarray	"mmu_circRNAs_22543 (also written as mmu_circRNA_22543) is an m6A-modified circRNA down-regulated in CIH (OSA) mouse left ventricular tissue and validated by MeRIP-qPCR. Bioinformatic ceRNA analysis predicted interactions with mmu-miR-5134-5p/mmu-miR-1896/mmu-miR-7242-3p and association with target genes including Clip2, Fadd, and Hacd2, suggesting a possible link to lipid metabolism via Clip2."	0.5803
40188043	BMC pulmonary medicine	2025	Genome-wide analysis of m6A-modified circRNAs in the mouse model of myocardial injury induced by obstructive sleep apnea.		mmu_circRNAs_29768 / mmu_circRNA_29768			obstructive sleep apnea / OSA	MONDO:0007147	obstructive sleep apnea syndrome	down-regulated	RT-qPCR; Microarray	"mmu_circRNAs_29768 (also shown as mmu_circRNA_29768) is an m6A-modified circRNA down-regulated in the CIH (OSA) mouse left ventricle and validated by MeRIP-qPCR. It was included for computational ceRNA network construction, but specific miRNA/mRNA partners for this circRNA were not provided in the text."	0.5803
40189516	Respiratory research	2025	Intranasal delivery of R8-modified circNFXL1 liposomes ameliorates Su5416-induced pulmonary arterial hypertension in C57BL/6 mice.		circNFXL1	mmu_circ_Nfxl1	NFXL1	pulmonary arterial hypertension / PAH	MONDO:0015924	pulmonary arterial hypertension	down-regulated	RT-qPCR; ISH	"In Su5416/hypoxia-induced PAH in C57BL/6 mice, circNFXL1 is decreased, and restoring it via intranasal R8-liposomes alleviates pulmonary vascular remodeling and right ventricular hypertrophy. Mechanistically, circNFXL1 acts as a miRNA sponge for miR-29b, thereby relieving repression of Kcnb1/KCNB1."	0.6815
40191465	Rheumatology and immunology research	2025	Circ_0088200 acts as a sponge for miR-127-5p to promote the migration and invasion of rheumatoid arthritis fibroblast-like synoviocytes.	hsa_circ_0088200 	CircRNA_0088200	hsa_circ_TNC	TNC	rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; Microarray	"Circ_0088200 is upregulated in RA-FLS and promotes their migration and invasion. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-127_5p to derepress MMP1; in CIA mice, AAV-mediated Circ_0088200 increases arthritis severity."	0.8228
40192802	Cellular and molecular life sciences : CMLS	2025	Circular RNA circSTX12 regulates osteo-adipogenic balance and proliferation of BMSCs in senile osteoporosis.	hsa_circ_0008126	circSTX12	hsa_circ_STX12	STX12	osteoporosis	MONDO:0005298	osteoporosis	up-regulated	RT-qPCR; ISH	"circSTX12 is up-regulated in senile osteoporosis bone/BMSCs and shifts BMSC fate toward adipogenesis while suppressing osteogenesis and proliferation. Mechanistically, it binds CBL to inhibit MST1 ubiquitination/degradation, activating Hippo signaling and limiting YAP nuclear signaling during differentiation, and it sequesters LMO7 in the cytoplasm to reduce CCNA2/CCNH/CCND1 transcription and inhibit proliferation. ASO-mediated knockdown of circStx12 improves bone formation in aged mice."	0.8839
40196178	Frontiers in aging neuroscience	2025	Loss of age-accumulated crh-1 circRNAs ameliorate amyloid beta-induced toxicity in a C. elegans model for Alzheimer's disease.	cel_circ_0000439	circ-crh-1	cel_circ_crh-1	crh-1	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR	"In a transgenic C. elegans Abeta1_42 proteotoxicity model, circ-crh-1 is up-regulated after Abeta induction and promotes Abeta-induced paralysis, Abeta aggregate accumulation, and lifespan shortening. Genetic loss of circ-crh-1 is protective and the delayed paralysis phenotype depends on col-49 expression; the study proposes circ-crh-1 may act via RBP-mediated post-transcriptional regulation affecting col-49."	0.3513
40200350	BMC women's health	2025	Silencing circRNA-ZFAND6 induces trophoblast apoptosis by activating the mitochondrial pathway through the miR-575/SOD2 axis in unexplained recurrent spontaneous abortion.	hsa_circ_0000643	circRNA-ZFAND6 / circRNA-0000643	hsa_circ_ZFAND6	ZFAND6	Recurrent Spontaneous Abortion / RSA	MONDO:0013727	"pregnancy loss, recurrent, susceptibility to, 1"	down-regulated	RT-qPCR; Microarray	"In URSA placental villous tissues, circRNA-ZFAND6 (hsa_circ_0000643) is down-regulated. It mainly localizes in the cytoplasm and acts as a ceRNA to sponge miR-575, relieving miR-575-mediated repression of SOD2, thereby reducing mitochondria-mediated trophoblast apoptosis and promoting trophoblast proliferation."	0.8459
40208437	Cell biology and toxicology	2025	Dysregulation of the circ-Hdac4/miR-30c/RBPJ axis in decidua impairs placental function in preeclampsia.		circ-Hdac4	mmu_circ_Hdac4	Hdac4	preeclampsia	MONDO:0005081	preeclampsia	down-regulated	RT-qPCR; ISH; Microarray	"In mouse decidua, circ-Hdac4 is required for stromal cell decidualization and supports normal placental function. Mechanistically, it acts as a cytoplasmic miRNA sponge for miR-30c, thereby relieving inhibition of RBPJ; loss of circ-Hdac4 worsens preeclampsia-like phenotypes in a RUPP mouse model."	0.7533
40208437	Cell biology and toxicology	2025	Dysregulation of the circ-Hdac4/miR-30c/RBPJ axis in decidua impairs placental function in preeclampsia.	hsa_circ_0058913		hsa_circ_Hdac4	Hdac4	preeclampsia	MONDO:0005081	preeclampsia	down-regulated	RT-qPCR	"In human preeclampsia decidual surface of placental tissues, hsa_circ_0058913 is reduced versus controls and shows positive correlation with RBPJ expression, suggesting a conserved association with the decidual regulatory program implicated in placental dysfunction."	0.348
40210941	Scientific reports	2025	CircSCD1 inhibits ferroptosis in breast Cancer through stabilizing SCD1 protein via deubiquitinase OTUB1.	hsa_circ_0019512	circSCD1	hsa_circ_SCD1	SCD1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circSCD1 is upregulated in breast cancer cell lines and promotes tumor cell viability/proliferation. It suppresses ferroptosis by recruiting the deubiquitinase OTUB1 to reduce SCD1 ubiquitination, stabilizing SCD1 protein and supporting tumor growth in xenograft models."	0.8344
40211126	Biological procedures online	2025	Construction of a circRNA-miRNA-mRNA Regulatory Network for the Immune Regulation of Lung Adenocarcinoma.	hsa_circ_0079557				lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0079557 is up-regulated in LUAD (cell lines and patient blood). Its knockdown suppresses LUAD cell proliferation/viability and reduces migration and invasion, partly consistent with inhibition of EMT marker changes. The circRNA is placed in a predicted ceRNA network involving hsa-miR-502-5p and OAS1."	0.5802
40214644	Investigative ophthalmology & visual science	2025	Treatment of Pathological Lymphangiogenesis via Circular RNA-Mediated Cholesterol Metabolism Remodeling.	hsa_circ_0131722	circRNA-KIF6 / cKIF6	hsa_circ_KIF6	KIF6	pathological lymphangiogenesis	MONDO:0005833	lymphatic system disorder	up-regulated	RT-qPCR; ISH; RNA-seq; Microarray	"cKIF6 is up-regulated in inflammatory/pathological lymphangiogenesis models and in corneal tissue from keratitis patients. It promotes LEC proliferation/migration/tube formation and lymphangiogenesis by sponging miR-582 to increase MSMO1 expression, thereby enhancing cholesterol biosynthesis; cholesterol synthesis inhibitors attenuate cKIF6-driven lymphangiogenesis."	0.7828
40220480	"Clinics (Sao Paulo, Brazil)"	2025	hsa_circ_0095812 accelerates periodontitis progression by adsorbing miR-485-3p-mediated THBS1 expression.	hsa_circ_0095812	circLRRC4C	hsa_circ_LRRC4C	LRRC4C	periodontitis	MONDO:0005076	periodontitis	up-regulated	RT-qPCR	"hsa_circ_0095812 (circLRRC4C) is up-regulated in periodontitis tissues and in LPS-treated PDLCs. It promotes inflammation, apoptosis and pyroptosis by sponging miR-485-3p to increase THBS1, and its knockdown alleviates periodontitis in a Porphyromonas gingivalis-induced mouse model."	0.7792
40222337	Translational oncology	2025	circHIPK2 promotes malignant progression of laryngeal squamous cell carcinoma through the miR-889-3p/MCTS1/IL-6 axis.		circHIPK2	hsa_circ_HIPK2	HIPK2	laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR	"circHIPK2 is up-regulated in LSCC tissues and cell lines and promotes proliferation and migration. It mainly localizes to the cytoplasm and functions as a ceRNA by sponging miR-889_3p, thereby increasing MCTS1 expression and enhancing IL-6 secretion to accelerate malignant progression, with potential diagnostic/prognostic value."	0.8175
40226122	Practical laboratory medicine	2025	Integrative analysis of exosomal ncRNAs and their regulatory networks in liver cancer progression.	hsa_circ_0001380				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	dysregulated	RNA-seq	"This study identified hsa_circ_0001380 as a differentially expressed exosomal circRNA in hepatocellular carcinoma. It was predicted to physically interact with 23 of 24 analyzed miRNAs (all except hsa-miR-30c-5p), suggesting a potential role in post-transcriptional regulation through a miRNA-centered regulatory network. The circRNA was proposed as a candidate biomarker and potential therapeutic target for liver cancer."	0.1768
40226123	Practical laboratory medicine	2025	Evaluation of CircHIPK3 biomarker potential in breast cancer.	hsa_circ_0000284	CircHIPK3 / Circ HIPK3	hsa_circ_HIPK3	HIPK3	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	circHIPK3 (hsa_circ_0000284) is up-regulated in breast cancer tissues and patient plasma. It shows diagnostic utility (AUC 0.8087) and its high expression is associated with larger tumor size; combining it with CA-15-3 and CEA improves diagnostic performance.	0.5963
40226576	Journal of cell communication and signaling	2025	NS3 of hepatitis C virus drives hepatocellular carcinoma progression through a novel RNA-interference pathway.	hsa_circ_0001175	circ_0001175 / circYTHDF1	hsa_circ_YTHDF1	YTHDF1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"In HCV-related HCC, NS3 upregulates circ_0001175 (circYTHDF1), which mainly localizes to the cytoplasm and sponges miR-130a-5p. This relieves miR-130a-5p-mediated suppression of MDM4, inhibits P53/p21 signaling, and promotes proliferation, migration, invasion, EMT, tumor growth and metastasis."	0.8256
40229458	Molecular neurobiology	2025	Exosomal circ_0001583 Drives Glioblastoma Cell Advancement Through the miR-647/CKAP2L Pathway.	hsa_circ_0001583	circ_0001583 / CircRNA	hsa_circ_HIST1H1C	HIST1H1C	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; RNA-seq	"circ_0001583 is upregulated in glioblastoma and is mainly localized in the cytoplasm. It promotes GBM cell proliferation, invasion and glycolysis by sponging miR-647 and relieving repression of CKAP2L, and can be transferred via exosomes to normal astrocytes to enhance their proliferation."	0.8556
40231340	Iranian biomedical journal	2025	Role of hsa_Circ_0001821 in Colorectal Cancer Pathogenesis and Response to 5-Fluorouracil through miR-203a-3p/FGF-2 Axis.	hsa_circ_0001821	hsa_Circ_0001821 / circ-PVT1	hsa_circ_PVT1	PVT1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	unknown	RT-qPCR	"In HCT116 colorectal cancer cells, hsa_Circ_0001821 (circ-PVT1) promotes malignant phenotypes and 5-FU chemoresistance by sponging hsa-miR-203a-3p to maintain higher FGF-2 expression. Silencing hsa_Circ_0001821 decreases viability and migration and increases apoptosis, enhancing sensitivity to 5-FU."	0.4546
40231634	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2025	CircRNA-mTOR Promotes Hepatocellular Carcinoma Progression and Lenvatinib Resistance Through the PSIP1/c-Myc Axis.	hsa_circ_0009792	circRNA_mTOR	hsa_circ_MTOR	mTOR	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circRNA-mTOR is upregulated in HCC and promotes tumor progression and lenvatinib resistance by enhancing stemness. Mechanistically, it binds PSIP1 to increase PSIP1 nuclear translocation, which increases nuclear c-Myc retention/stability (reduced ubiquitination), activating the PSIP1/c-Myc axis."	0.8999
40233410	Proceedings of the National Academy of Sciences of the United States of America	2025	A circRNA-mRNA pairing mechanism regulates tumor growth and endocrine therapy resistance in ER-positive breast cancer.	hsa_circ_0000816	circFOXK2	hsa_circ_FOXK2	FOXK2	ER-positive breast cancer	MONDO:0006512	estrogen-receptor positive breast cancer	up-regulated	RT-qPCR; RNA-seq	"circFOXK2 is up-regulated in breast tumors and promotes ER-positive breast cancer growth and endocrine (tamoxifen) resistance. It directly pairs with the CCND1 3¡ä UTR and recruits ELAVL1/HuR to increase CCND1 mRNA stability, enhancing CCND1 protein and downstream RB phosphorylation/E2F-driven G1/S progression. ASO-mediated targeting of circFOXK2 suppresses xenograft tumor growth and restores tamoxifen sensitivity in resistant cells."	0.872
40234780	BMC cancer	2025	Dual Cas12a and multiplex crRNA CRISPR strategy ultrasensitive detection novel circRNA biomarker for the diagnosis of ovarian cancer.	hsa_circ_0049101	hsa_circ_0049101 / circMUC16	hsa_circ_MUC16	MUC16	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; RNA-seq	"This study identified circMUC16 (hsa_circ_0049101) as an up-regulated circRNA in ovarian cancer and validated its specific expression in OC cell lines and patient peripheral blood. circMUC16 was suggested to act as a miRNA sponge within a circRNA-miRNA-mRNA network linked to proliferation and migration, and showed strong diagnostic performance when quantified by the DCMC-CRISPR assay."	0.559
40243558	International journal of molecular sciences	2025	Circ_RUSC2 Sequesters miR-661 and Elevates TUSC2 Expression to Suppress Colorectal Cancer Progression.	hsa_circ_0002702	circ_RUSC2	hsa_circ_RUSC2	RUSC2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"circ_RUSC2 is downregulated in colorectal cancer tissues and cell lines and is associated with more aggressive clinicopathological features. Functionally, circ_RUSC2 suppresses CRC cell proliferation, migration and invasion by sponging miR-661 to relieve repression of the tumor suppressor TUSC2. Its stability is enhanced by METTL3-associated m6A modification."	0.8432
40248098	Frontiers in pharmacology	2025	Circ_0098181 binds PKM2 to attenuate liver fibrosis.	hsa_circ_0098181	circ_0098181	hsa_circ_SOX5	SOX5	liver fibrosis	MONDO:0005155	cirrhosis of liver	down-regulated	RT-qPCR; RNA-seq	"circ_0098181 is down-regulated in cirrhotic/fibrotic liver tissues and activated HSCs. Overexpression of circ_0098181 suppresses HSC activation, proliferation, and migration, reduces inflammatory cytokine expression, and ameliorates CCl4-induced liver fibrosis. Mechanistically, it directly binds PKM2 to inhibit PKM2 nuclear translocation/phosphorylation, and its biogenesis is negatively regulated by ADAR1 binding to flanking intronic complementary sequences."	0.7469
40248379	World journal of gastroenterology	2025	Extramural venous invasion in gastric cancer: 9.4T magnetic resonance imaging assessment and circular RNA functional analysis.	hsa_circ_0097977		hsa_circ_ATF7IP	ATF7IP	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0097977 is up-regulated in EMVI-positive gastric cancer samples and is functionally pro-tumorigenic. Its knockdown reduces EMVI and cell invasion while increasing apoptosis, and bioinformatics suggests a ceRNA mechanism involving hsa-miR-107/hsa-miR-214-3p and predicted downstream mRNA targets."	0.5089
40250444	Cancer cell	2025	Circular RMST cooperates with lineage-driving transcription factors to govern neuroendocrine transdifferentiation.		circRMST / circRMST 3_10	hsa_circ_RMST	RMST	neuroendocrine prostate cancer / NEPC	MONDO:0002477	prostate neuroendocrine neoplasm	up-regulated	RT-qPCR; Northern Blot; ISH; RNA-seq	"circRMST is highly up-regulated in NEPC and ASCL1-subtype SCLC models and is required for neuroendocrine tumor growth and maintenance of ASCL1-driven lineage programs. It functions mainly through protein interactions with NKX2-1 and SOX2, promoting NKX2-1 stability (blocking autophagy-lysosomal degradation) and modulating SOX2 chromatin binding to sustain ASCL1 transcription."	0.8392
40250444	Cancer cell	2025	Circular RMST cooperates with lineage-driving transcription factors to govern neuroendocrine transdifferentiation.		circRmst / circRmst 3_12	mmu_circ_Rmst	Rmst	neuroendocrine prostate cancer / NEPC	MONDO:0002477	prostate neuroendocrine neoplasm	up-regulated	RT-qPCR; RNA-seq	"Mouse circRmst (notably isoform 3_12) is strongly up-regulated in NEPC GEMMs (DKO/TKO) and absent in SKO adenocarcinoma, supporting association with neuroendocrine transdifferentiation. Functional perturbation in mouse KP1 cells and genetic deletion of Rmst in GEMMs indicate circRmst is required for NE tumor growth and maintenance of Ascl1 expression, with evidence of physical binding to Nkx2-1."	0.6579
40258819	Cell death & disease	2025	Circular PVT1 promotes cardiac fibroblast activation interacting with miR-30a-5p and miR-125b-5p.	hsa_circ_0001821	circular PVT1 / circPVT1	hsa_circ_PVT1	PVT1	ischemic heart failure / IHF	MONDO:0005252	heart failure	up-regulated	RT-qPCR	"circPVT1 is up-regulated in the left ventricle of ischemic heart failure patients and increases in fibrotic conditions (TGF-beta1-stimulated human cardiac fibroblasts). Functionally, circPVT1 promotes cardiac fibroblast activation and pro-fibrotic marker expression, at least partly by binding miR-30a-5p and miR-125b-5p and modulating miRNA target-gene repression and TGF-beta/SMAD signaling."	0.8012
40259294	Cancer cell international	2025	Hsa_circ_0072088 promotes non-small cell lung cancer progression through modulating miR-1270/TOP2A axis.	hsa_circ_0072088	hsa_circRNA_103809 / circZFR	hsa_circ_ZFR	ZFR	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"This study reports that circ_0072088 is up-regulated in NSCLC and promotes malignant phenotypes (proliferation and migration) while inhibiting apoptosis. Mechanistically, circ_0072088 functions as a ceRNA by sponging miR-1270 to increase TOP2A expression, forming a circ_0072088/miR-1270/TOP2A axis."	0.6777
40260530	Renal failure	2025	Circ-0069561 as a novel diagnostic biomarker for progression of diabetic kidney disease.	hsa_circ_0069561	Circ-0069561 / circRNA-0069561	hsa_circ_APBB2	APBB2	diabetic kidney disease / DKD	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR; RNA-seq	"circ-0069561 is up-regulated in DKD renal tissues and in diabetic mouse kidneys. Functionally, it aggravates high-glucose-induced podocyte injury and promotes ferroptosis; knockdown is protective. Clinically, higher circ-0069561 is associated with massive proteinuria risk and worse event-free outcomes."	0.7773
40260530	Renal failure	2025	Circ-0069561 as a novel diagnostic biomarker for progression of diabetic kidney disease.			mmu_circ_APBB2	APBB2	diabetic kidney disease / DKD	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR; RNA-seq	"circ-0069561 is up-regulated in DKD renal tissues and in diabetic mouse kidneys. Functionally, it aggravates high-glucose-induced podocyte injury and promotes ferroptosis; knockdown is protective. Clinically, higher circ-0069561 is associated with massive proteinuria risk and worse event-free outcomes."	0.7773
40263288	Cell death discovery	2025	QKI-induced circ_0001766 inhibits colorectal cancer progression and rapamycin resistance by miR-1203/PPP1R3C/mTOR/Myc axis.	hsa_circ_0001766	circ_0001766	hsa_circ_PDIA4	PDIA4	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; ISH; Microarray	"circ_0001766 (hsa_circ_0001766), generated from PDIA4 and promoted by the RBP QKI, is down-regulated in colorectal cancer. It localizes mainly in the cytoplasm and suppresses CRC proliferation, migration/invasion, metastasis and rapamycin resistance by sponging miR-1203 to sustain PPP1R3C expression, thereby inhibiting mTOR signaling and Myc phosphorylation. Higher circ_0001766 expression is associated with better OS/PFS."	0.8684
40264707	Frontiers in cell and developmental biology	2025	circ-0001454 alleviates asthma airway inflammation and remodeling via sponging miR-770-5p and regulating cbl-b.	hsa_circ_0001454	circ-0001454	hsa_circ_KIAA0922	KIAA0922	asthma / asthma	MONDO:0004979	asthma	down-regulated	RT-qPCR	"circ-0001454 is down-regulated in asthma/HDM-induced inflammation. Its upregulation alleviates airway inflammation and remodeling and protects bronchial epithelial cells by acting as a ceRNA that sponges miR-770-5p to increase cbl-b and modulate downstream EGFR/AKT1/MAPK1 and inflammatory mediators, reducing ROS, apoptosis, and mitochondrial dysfunction."	0.8207
40269559	Cancer biology & medicine	2025	Cancer-derived exosomal circTMEM56 enhances the efficacy of HCC radiotherapy through the miR-136-5p/STING axis.	hsa_circ_0005720	circTMEM56	hsa_circ_TMEM56	TMEM56	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"In HCC, circTMEM56 (hsa_circ_0005720) is reduced in tumor tissue and low expression associates with worse RT response and prognosis. Mechanistically, exosomal circTMEM56 functions as a ceRNA in the cytoplasm to sponge miR-136-5p, relieving inhibition of STING/STING1 and activating cGAS-STING_IFN signaling in dendritic cells to boost anti-tumor immunity and radiotherapy efficacy."	0.8429
40272569	Cellular and molecular life sciences : CMLS	2025	circCEP70 encoded protein inhibits the progression of hepatocellular carcinoma.		circCEP70	hsa_circ_CEP70	CEP70	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circCEP70 is up-regulated in cirrhotic-background HCC and is associated with better patient survival. It suppresses HCC proliferation and metastasis mainly by encoding the protein CEP70-160aa, which binds PKM2, blocks PKM2 nuclear translocation, and reduces nuclear STAT3 phosphorylation within the JAK/STAT pathway context; U2AF2 negatively regulates circCEP70 biogenesis via binding flanking introns."	0.8748
40273295	Cardiovascular research	2025	A new protein isoform encoded by human circular RNA circSLC8a1 contributes to cardiac remodelling.	hsa_circ_0005232	circSLC8a1 / circLSC8a1	hsa_circ_SLC8A1	SLC8A1	heart failure / HF	MONDO:0005252	heart failure	up-regulated	RT-qPCR	"In heart failure/cardiac pressure-overload remodelling, circSLC8a1 is up-regulated and exerts pathogenic effects mainly by being translated into SLC8a1-604. The translated protein interacts with TIMM50 and POLRMT in mitochondria to repress mitochondrial gene transcription and ATP production, contributing to impaired cardiac function and remodelling/fibrosis."	0.7766
40273496	"Clinics (Sao Paulo, Brazil)"	2025	"circPOLA2 promotes proliferation, invasion, migration, and epithelial-mesenchymal transition in breast cancer via the miR-1224-5p/HMGA2 axis."		circPOLA2 / circ_POLA2	hsa_circ_POLA2	POLA2	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circPOLA2 is upregulated in breast cancer tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion, EMT) while inhibiting apoptosis. Mechanistically, circPOLA2 functions as a ceRNA that sponges miR-1224_5p to increase HMGA2 expression, and circPOLA2 knockdown suppresses xenograft tumor growth."	0.8534
40274885	Scientific reports	2025	Differential expression and functional analysis of circular RNAs and m6A modifications in children with Philadelphia chromosome-positive acute lymphoblastic leukemia.	hsa_circ_0012152				Philadelphia chromosome-positive acute lymphoblastic leukemia / Ph+ ALL / Ph+ B-ALL	MONDO:0000870	childhood acute lymphoblastic leukemia	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0012152 is up-regulated in Ph+ ALL compared with Ph_ ALL and was validated by RT-qPCR in B-ALL cell lines and clinical bone marrow samples, suggesting potential diagnostic value. Its mechanism was not experimentally characterized, though m6A sites on top DECs were computationally predicted."	0.4032
40274885	Scientific reports	2025	Differential expression and functional analysis of circular RNAs and m6A modifications in children with Philadelphia chromosome-positive acute lymphoblastic leukemia.	hsa_circ_0009024				Philadelphia chromosome-positive acute lymphoblastic leukemia / Ph+ ALL / Ph+ B-ALL	MONDO:0000870	childhood acute lymphoblastic leukemia	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0009024 is up-regulated in Ph+ ALL compared with Ph_ ALL and was validated by RT-qPCR in B-ALL cell lines and clinical bone marrow samples, suggesting potential diagnostic value. Its mechanism was not experimentally characterized, though m6A sites on top DECs were computationally predicted."	0.4032
40275292	Journal of translational medicine	2025	Transcriptome-scale analysis of functional alternative back-splicing events in colorectal cancer.		circXPO1-2	hsa_circ_XPO1	XPO1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"circXPO1-2 is significantly down-regulated in colorectal cancer tissues and is mainly localized in the cytoplasm. Its overexpression suppresses CRC cell proliferation, migration, invasion and xenograft tumor growth, potentially by down-regulating AKT/ERK-associated regulators (e.g., VASP, KRT17) and shifting gene programs toward apoptosis and oxidative phosphorylation."	0.7663
40279507	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2025	Collaborative Duality of CircGLIS3(2) RNA and Protein in human Wound Repair.	hsa_circ_0002874	CircGLIS3(2) / CircGlis3	hsa_circ_GLIS3	GLIS3	keloid	MONDO:0005348	keloid	up-regulated	RT-qPCR; RNA-seq; Microarray	"CircGLIS3(2) is up-regulated in dermal fibroblasts during acute human wound healing and is overexpressed in keloids. Its RNA form promotes TGF-beta1-driven fibroblast activation/ECM production by binding and stabilizing PCOLCE, while its encoded protein promotes cell-cycle progression and proliferation by binding and stabilizing BTF3, together supporting wound closure."	0.8588
40279507	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2025	Collaborative Duality of CircGLIS3(2) RNA and Protein in human Wound Repair.	mmu_circ_0007673	CircGLIS3(2) / CircGlis3	mmu_circ_GLIS3	GLIS3	keloid	MONDO:0005348	keloid	up-regulated	RT-qPCR; RNA-seq; Microarray	"CircGLIS3(2) is up-regulated in dermal fibroblasts during acute human wound healing and is overexpressed in keloids. Its RNA form promotes TGF-beta1-driven fibroblast activation/ECM production by binding and stabilizing PCOLCE, while its encoded protein promotes cell-cycle progression and proliferation by binding and stabilizing BTF3, together supporting wound closure."	0.8588
40281642	Arthritis research & therapy	2025	circ_0002970 promotes fibroblast-like synoviocytes invasion and the inflammatory response through Hippo/YAP signaling to induce CTGF/CCN1 expression in rheumatoid arthritis.	hsa_circ_0002970	circ_0002970	hsa_circ_CEMIP	CEMIP	rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; RNA-seq	"circ_0002970 is upregulated in RA fibroblast-like synoviocytes and promotes migration, invasion, and inflammatory IL-6 secretion. It acts by activating Hippo/YAP signaling and increasing YAP with downstream CTGF and CCN1 expression; inhibiting Hippo/YAP (verteporfin) reverses circ_0002970-driven phenotypes."	0.7589
40285567	Veterinary medicine and science	2025	"Integrative Analysis of Dog Serum-Derived CircRNA Expression and Disease Severity, Inflammatory and Cardiac Damage Biomarkers Related to Canine Parvoviral Enteritis."		cfa_circ_1570			canine parvovirus infection / CPV infection	MONDO:0025371	Parvoviridae infectious disease	dysregulated	RT-qPCR; RNA-seq	"cfa_circ_1570 was identified as a candidate circRNA biomarker in this CPV study and showed a strong positive correlation with TNF-alpha, suggesting an association with inflammatory status."	0.4032
40285567	Veterinary medicine and science	2025	"Integrative Analysis of Dog Serum-Derived CircRNA Expression and Disease Severity, Inflammatory and Cardiac Damage Biomarkers Related to Canine Parvoviral Enteritis."		cfa_circ_1571			canine parvovirus infection / CPV infection	MONDO:0025371	Parvoviridae infectious disease	dysregulated	RT-qPCR; RNA-seq	"cfa_circ_1571 was linked to cardiac damage in CPV infection and showed negative correlations with cardiac biomarkers, suggesting a possible compensatory/protective association."	0.4032
40285567	Veterinary medicine and science	2025	"Integrative Analysis of Dog Serum-Derived CircRNA Expression and Disease Severity, Inflammatory and Cardiac Damage Biomarkers Related to Canine Parvoviral Enteritis."		cfa_circ_3113			canine parvovirus infection / CPV infection	MONDO:0025371	Parvoviridae infectious disease	up-regulated	RT-qPCR; RNA-seq	"cfa_circ_3113 was elevated in CPV-infected dogs and correlated positively with cardiac injury biomarkers (cTnI, CK-MB), supporting its potential as a serum marker of CPV-associated cardiac damage."	0.4032
40285567	Veterinary medicine and science	2025	"Integrative Analysis of Dog Serum-Derived CircRNA Expression and Disease Severity, Inflammatory and Cardiac Damage Biomarkers Related to Canine Parvoviral Enteritis."		cfa_circ_3114			canine parvovirus infection / CPV infection	MONDO:0025371	Parvoviridae infectious disease	up-regulated	RT-qPCR; RNA-seq	"cfa_circ_3114 was detected only in the mild CPV group and correlated strongly with cardiac injury biomarkers, supporting its use as a candidate serum marker for CPV-associated myocardial damage."	0.4032
40285567	Veterinary medicine and science	2025	"Integrative Analysis of Dog Serum-Derived CircRNA Expression and Disease Severity, Inflammatory and Cardiac Damage Biomarkers Related to Canine Parvoviral Enteritis."		cfa_circ_3117			canine parvovirus infection / CPV infection	MONDO:0025371	Parvoviridae infectious disease	up-regulated	RT-qPCR; RNA-seq	"cfa_circ_3117 was detected only in the mild CPV group and correlated positively with cTnI/CK-MB, indicating a close association with CPV-related cardiac injury."	0.4032
40285567	Veterinary medicine and science	2025	"Integrative Analysis of Dog Serum-Derived CircRNA Expression and Disease Severity, Inflammatory and Cardiac Damage Biomarkers Related to Canine Parvoviral Enteritis."		cfa_circ_3118			canine parvovirus infection / CPV infection	MONDO:0025371	Parvoviridae infectious disease	up-regulated	RT-qPCR; RNA-seq	"cfa_circ_3118 was expressed only in the mild CPV group and correlated strongly with cardiac biomarkers, indicating association with CPV-related myocardial damage."	0.4032
40285567	Veterinary medicine and science	2025	"Integrative Analysis of Dog Serum-Derived CircRNA Expression and Disease Severity, Inflammatory and Cardiac Damage Biomarkers Related to Canine Parvoviral Enteritis."		cfa_circ_3119			canine parvovirus infection / CPV infection	MONDO:0025371	Parvoviridae infectious disease	up-regulated	RT-qPCR; RNA-seq	"cfa_circ_3119 was elevated in the mild group and associated with both inflammation/disease severity and cardiac injury markers, showing a negative correlation with CRP and a positive correlation with cTnI."	0.4032
40285567	Veterinary medicine and science	2025	"Integrative Analysis of Dog Serum-Derived CircRNA Expression and Disease Severity, Inflammatory and Cardiac Damage Biomarkers Related to Canine Parvoviral Enteritis."		cfa_circ_6784			canine parvovirus infection / CPV infection	MONDO:0025371	Parvoviridae infectious disease	up-regulated	RT-qPCR; RNA-seq	"cfa_circ_6784 was detected only in the severe CPV group, indicating association with severe-stage CPV infection and potential utility as a serum biomarker candidate."	0.4032
40285567	Veterinary medicine and science	2025	"Integrative Analysis of Dog Serum-Derived CircRNA Expression and Disease Severity, Inflammatory and Cardiac Damage Biomarkers Related to Canine Parvoviral Enteritis."		cfa_circ_6785			canine parvovirus infection / CPV infection	MONDO:0025371	Parvoviridae infectious disease	up-regulated	RT-qPCR; RNA-seq	"cfa_circ_6785 was elevated in severe CPV infection and correlated positively with CRP, supporting its role as a serum biomarker candidate for inflammation and disease severity."	0.4032
40285567	Veterinary medicine and science	2025	"Integrative Analysis of Dog Serum-Derived CircRNA Expression and Disease Severity, Inflammatory and Cardiac Damage Biomarkers Related to Canine Parvoviral Enteritis."		cfa_circ_6786			canine parvovirus infection / CPV infection	MONDO:0025371	Parvoviridae infectious disease	up-regulated	RT-qPCR; RNA-seq	"cfa_circ_6786 was elevated in severe CPV infection and linked to cardiac damage, showing negative correlations with cardiac biomarkers, suggesting a possible compensatory/protective association."	0.4032
40285567	Veterinary medicine and science	2025	"Integrative Analysis of Dog Serum-Derived CircRNA Expression and Disease Severity, Inflammatory and Cardiac Damage Biomarkers Related to Canine Parvoviral Enteritis."		cfa_circ_6789			canine parvovirus infection / CPV infection	MONDO:0025371	Parvoviridae infectious disease	up-regulated	RT-qPCR; RNA-seq	"cfa_circ_6789 was elevated in severe CPV infection and strongly correlated with CRP, supporting its candidacy as a serum biomarker for inflammation and disease severity."	0.4032
40285567	Veterinary medicine and science	2025	"Integrative Analysis of Dog Serum-Derived CircRNA Expression and Disease Severity, Inflammatory and Cardiac Damage Biomarkers Related to Canine Parvoviral Enteritis."		cfa_circ_6791			canine parvovirus infection / CPV infection	MONDO:0025371	Parvoviridae infectious disease	up-regulated	RT-qPCR; RNA-seq	"cfa_circ_6791 was elevated in the severe CPV group and showed a moderate positive correlation with CRP, supporting its candidacy as an inflammation/disease severity biomarker in CPV infection."	0.4032
40285567	Veterinary medicine and science	2025	"Integrative Analysis of Dog Serum-Derived CircRNA Expression and Disease Severity, Inflammatory and Cardiac Damage Biomarkers Related to Canine Parvoviral Enteritis."		cfa_circ_6793			canine parvovirus infection / CPV infection	MONDO:0025371	Parvoviridae infectious disease	up-regulated	RT-qPCR; RNA-seq	"cfa_circ_6793 was elevated in severe CPV infection and correlated positively with CRP, supporting its candidacy as a serum biomarker for inflammation and disease severity."	0.4032
40285567	Veterinary medicine and science	2025	"Integrative Analysis of Dog Serum-Derived CircRNA Expression and Disease Severity, Inflammatory and Cardiac Damage Biomarkers Related to Canine Parvoviral Enteritis."		cfa_circ_6794			canine parvovirus infection / CPV infection	MONDO:0025371	Parvoviridae infectious disease	up-regulated	RT-qPCR; RNA-seq	"cfa_circ_6794 was elevated in severe CPV infection, correlated positively with CRP, and was also linked to cardiac damage with a negative correlation to cTnI, indicating dual association with inflammation severity and cardiac injury markers."	0.4032
40285567	Veterinary medicine and science	2025	"Integrative Analysis of Dog Serum-Derived CircRNA Expression and Disease Severity, Inflammatory and Cardiac Damage Biomarkers Related to Canine Parvoviral Enteritis."		cfa_circ_6795			canine parvovirus infection / CPV infection	MONDO:0025371	Parvoviridae infectious disease	up-regulated	RT-qPCR; RNA-seq	cfa_circ_6795 was detected only in the severe CPV group and was selected as a candidate circRNA biomarker distinguishing disease stage in CPV infection.	0.4032
40285567	Veterinary medicine and science	2025	"Integrative Analysis of Dog Serum-Derived CircRNA Expression and Disease Severity, Inflammatory and Cardiac Damage Biomarkers Related to Canine Parvoviral Enteritis."		cfa_circ_6798			canine parvovirus infection / CPV infection	MONDO:0025371	Parvoviridae infectious disease	up-regulated	RT-qPCR; RNA-seq	"cfa_circ_6798 was elevated in the severe CPV group and correlated positively with CRP, supporting its potential as a serum biomarker for inflammatory severity in CPV infection."	0.4032
40286845	Journal of advanced research	2025	CircPAFAH1B2 induces chondrocytes mitochondrial dysfunction and promotes cartilage degeneration through binding molecular chaperone ClpB.	hsa_circ_0007827	circPAFAH1B2	hsa_circ_PAFAH1B2	PAFAH1B2	osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; ISH	"circPAFAH1B2 is up-regulated in osteoarthritic cartilage and mainly localizes in the cytoplasm of chondrocytes. It directly binds the chaperone ClpB and prevents its mitochondrial import, reducing mitochondrial ClpB and leading to mitochondrial dysfunction, apoptosis, and cartilage degeneration in OA."	0.8422
40286845	Journal of advanced research	2025	CircPAFAH1B2 induces chondrocytes mitochondrial dysfunction and promotes cartilage degeneration through binding molecular chaperone ClpB.	mmu_circ_0001770	circPafah1b2	mmu_circ_Pafah1b2		osteoarthritis / OA	MONDO:0005178	osteoarthritis	unknown	ISH	The mouse homolog mmu_circ_0001770 (circPafah1b2) was detected in a DMM-induced OA model and was functionally manipulated in vivo; its overexpression or knockdown altered mitochondrial dysfunction and OA phenotypes in mouse joints.	0.6261
40288674	Journal of advanced research	2026	Circular RNA circATM binds PARP1 to suppress Wnt/beta-catenin signaling and induce cell cycle arrest in gastric cancer cells.	hsa_circ_0003641	circATM / circRNA_28305	hsa_circ_ATM	ATM	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; RNA-seq	"circATM is down-regulated in gastric cancer and functions as a tumor suppressor. It binds PARP1 (ZF¢ò_¢ó), promotes PARP1 ubiquitin_proteasome degradation and disrupts the PARP1/beta-catenin/TCF4 transcriptional complex, thereby suppressing Wnt/beta-catenin signaling and inducing G2/M cell cycle arrest, reducing proliferation and migration in vitro and tumor growth in vivo."	0.8079
40292405	International journal of nanomedicine	2025	Exosome-Delivered circFOXP1 Upregulates Autophagy and Promotes Hepatocellular Carcinoma Progression Through Its Encoded p196 Protein Targeting the KHDRBS3/ULK1 Axis.	hsa_circ_0008234	circFOXP1	hsa_circ_FOXP1	FOXP1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circFOXP1 (hsa_circ_0008234) is up-regulated in HCC tissues and cell lines and can be transferred via exosomes. It encodes a 196-aa protein (p196) that binds KHDRBS3 to stabilize ULK1 mRNA, increasing ULK1 protein and autophagy, thereby promoting HCC cell proliferation and invasion and accelerating tumor progression."	0.8747
40295824	Npj viruses	2025	Backsplicing of the HIV-1 transcript generates multiple circRNAs to promote viral replication.		CirR			HIV-1 infection	MONDO:0005109	HIV infectious disease	unknown	RT-qPCR	"CirR is an HIV-1-derived circRNA whose expression increases virion production and infectivity. It promotes viral replication by sponging the cellular miRNAs miR-6727-3p and miR-4722-3p, antagonizing their antiviral restriction."	0.6711
40299340	Biomedicines	2025	Migrasome Marker Epidermal Growth Factor Domain-Specific O-GlcNAc Transferase: Pan-Cancer Angiogenesis Biomarker and the Potential Role of circ_0058189/miR-130a-3p/EOGT Axis in Hepatocellular Carcinoma Progression and Sorafenib Resistance.	hsa_circ_0058189	circ_0058189	hsa_circ_SMRACAL1	SMRACAL1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	Microarray	"hsa_circ_0058189 is upregulated in HCC tissues and patient plasma and is enriched in exosomes from sorafenib-resistant HepG2 cells. It is proposed to promote HCC progression and sorafenib resistance by sponging hsa-miR-130a-3p, thereby relieving repression of EOGT in a ceRNA axis."	0.1768
40304434	Cancer medicine	2025	Whole Transcriptome Sequencing Analyzes the Interactions of mRNAs and ncRNAs in Cholangiocarcinoma.	hsa_circ_0025636		hsa_circ_RASSF8	RASSF8	cholangiocarcinoma / CCA	MONDO:0019087	cholangiocarcinoma	down-regulated	RNA-seq	"hsa_circ_0025636 is down-regulated in cholangiocarcinoma tumor tissue versus adjacent tissue and was included as a hub circRNA in a predicted circRNA_miRNA_mRNA ceRNA network involving miR-96-5p and miR-196b-5p. Its host gene is reported as RASSF8, but no experimental functional validation of this circRNA was performed."	0.1768
40304434	Cancer medicine	2025	Whole Transcriptome Sequencing Analyzes the Interactions of mRNAs and ncRNAs in Cholangiocarcinoma.	hsa_circ_0057335		hsa_circ_TFPI	TFPI	cholangiocarcinoma / CCA	MONDO:0019087	cholangiocarcinoma	down-regulated	RNA-seq	"hsa_circ_0057335 is down-regulated in cholangiocarcinoma tumor tissue versus adjacent tissue and was highlighted as a potentially crucial circRNA within a predicted circRNA_miRNA_mRNA ceRNA network (including miR-96-5p and miR-196b-5p). Its host gene is reported as TFPI, but the circRNA itself was not experimentally validated by RT-qPCR or functional assays in this paper."	0.1768
40308800	World journal of gastroenterology	2025	Interventional effect of hesperetin on N-methyl-N'-nitro-N-nitrosoguanidine-induced exosomal circ008274 in affecting normal cells to promote gastric carcinogenesis.	hsa_circ_0008274	circ0008274 / circ00008274			gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"This study identifies exosomal circ0008274 as a key circRNA downregulated in the MNNG-induced malignant transformation model and in TGES-1-derived exosomes. Hesperetin restores/upregulates exosomal circ0008274, which suppresses malignant phenotypes (proliferation, migration/invasion, EMT, and stemness) in recipient GES-1 cells by sponging miR-526b-5p (ceRNA mechanism)."	0.7204
40317040	Journal of cardiothoracic surgery	2025	Circ-PSMB1 knockdown inhibits the pyroptosis of ox-LDL treated human aortic cells via the miR-624-3p/ASC axis.	hsa_circ_0078786	circ-PSMB1 / circ-proteasome 20 S subunit beta 1	hsa_circ_PSMB1	PSMB1	atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"circ-PSMB1 is up-regulated in ox-LDL_treated HAECs and in AS patient serum. It promotes endothelial pyroptosis by sponging miR-624-3p to increase ASC expression, thereby elevating pyroptosis/inflammatory markers (e.g., NLRP3, GSDMD-N, IL-1beta, IL-18)."	0.7759
40317362	Clinical and experimental medicine	2025	Integrative analysis of glioblastoma multiforme: the power of non-coding RNAs and hub genes in cancer research.	hsa_circ_0000227		hsa_circ_ZEB1	ZEB1	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	Microarray	"hsa_circ_0000227 is up-regulated in GBM microarray datasets and was included in a predicted ceRNA network. The study suggests it may act as a miRNA sponge to influence downstream mRNA expression, but provides no experimental validation."	0.1768
40317362	Clinical and experimental medicine	2025	Integrative analysis of glioblastoma multiforme: the power of non-coding RNAs and hub genes in cancer research.	hsa_circ_0000228		hsa_circ_ZEB1	ZEB1	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	Microarray	"hsa_circ_0000228 is up-regulated in GBM microarray datasets and was included in a predicted ceRNA network. The study suggests it may act as a miRNA sponge to influence downstream mRNA expression, but provides no experimental validation."	0.1768
40317362	Clinical and experimental medicine	2025	Integrative analysis of glioblastoma multiforme: the power of non-coding RNAs and hub genes in cancer research.	hsa_circ_0002641		hsa_circ_ZEB1	ZEB1	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	Microarray	"hsa_circ_0002641 is up-regulated in GBM microarray datasets and was included in a predicted ceRNA network. The study suggests it may act as a miRNA sponge to influence downstream mRNA expression, but provides no experimental validation."	0.1768
40317362	Clinical and experimental medicine	2025	Integrative analysis of glioblastoma multiforme: the power of non-coding RNAs and hub genes in cancer research.	hsa_circ_0072688	circADAMTS6	hsa_circ_ADAMTS6	ADAMTS6	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	Microarray	"hsa_circ_0072688 (circADAMTS6) is up-regulated in GBM microarray data and was included in the study¡¯s predicted ceRNA network. The discussion describes circADAMTS6 as promoting proliferation and inhibiting apoptosis via the ANXA2/NF-kappaB pathway and being regulated by AP-1 under hypoxia, but these functional claims were not experimentally validated in this paper."	0.1768
40319271	Journal of translational medicine	2025	The biomarker potential of circPOLD1 and its binding protein YBX1 in cervical carcinogenesis.	hsa_circ_0052012	circPOLD1	hsa_circ_POLD1	POLD1	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Northern Blot; ISH; RNA-seq	"circPOLD1 is progressively up-regulated from normal cervix to HSIL and CSCC and acts as an oncogenic circRNA. It directly binds the RBP YBX1, promotes YBX1 phosphorylation, and activates AKT/mTOR/HIF-1alpha-associated glycolysis to enhance cervical cancer cell proliferation and tumor growth; it also shows diagnostic potential in tissue (BaseScope) and serum (ROC)."	0.8834
40320447	Scientific reports	2025	Characterization of circRNA expression profiles and functional roles in a mouse model of liver injury induced by OSA.		mmu_circRNA_36790			obstructive sleep apnea / OSA	MONDO:0007147	obstructive sleep apnea syndrome	up-regulated	RT-qPCR; Microarray	mmu_circRNA_36790 is up-regulated in liver tissue from CIH (OSA-related) mice versus controls. The study validated its differential expression by qRT-PCR but did not report a specific downstream miRNA/mRNA axis or functional assays for this circRNA.	0.3684
40320447	Scientific reports	2025	Characterization of circRNA expression profiles and functional roles in a mouse model of liver injury induced by OSA.		mmu_circRNA_37101			obstructive sleep apnea / OSA	MONDO:0007147	obstructive sleep apnea syndrome	up-regulated	RT-qPCR; Microarray	"mmu_circRNA_37101 is up-regulated in CIH-induced mouse liver injury and was validated by qRT-PCR, but no specific miRNA/mRNA partners or functional mechanism were reported for this circRNA."	0.3684
40320447	Scientific reports	2025	Characterization of circRNA expression profiles and functional roles in a mouse model of liver injury induced by OSA.		mmu_circRNA_35781			obstructive sleep apnea / OSA	MONDO:0007147	obstructive sleep apnea syndrome	up-regulated	RT-qPCR; Microarray	"mmu_circRNA_35781 is significantly up-regulated in CIH-induced liver injury in mice and was validated by qRT-PCR. The study predicts that it targets multiple miRNAs and participates in a circRNA-miRNA-mRNA ceRNA network, but the predicted interactions were not experimentally validated (e.g., no luciferase assay)."	0.3684
40320447	Scientific reports	2025	Characterization of circRNA expression profiles and functional roles in a mouse model of liver injury induced by OSA.		mmu_circRNA_36551			obstructive sleep apnea / OSA	MONDO:0007147	obstructive sleep apnea syndrome	up-regulated	RT-qPCR; Microarray	"mmu_circRNA_36551 is up-regulated in CIH-induced mouse liver injury and was validated by qRT-PCR, but no specific interacting miRNAs/mRNAs or functional mechanism were reported for this circRNA."	0.3684
40320447	Scientific reports	2025	Characterization of circRNA expression profiles and functional roles in a mouse model of liver injury induced by OSA.		mmu_circRNA_44178			obstructive sleep apnea / OSA	MONDO:0007147	obstructive sleep apnea syndrome	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_44178 is down-regulated in CIH-induced mouse liver injury and was validated by qRT-PCR, but the study did not report specific interacting miRNAs/mRNAs or functional assays for this circRNA."	0.3684
40320447	Scientific reports	2025	Characterization of circRNA expression profiles and functional roles in a mouse model of liver injury induced by OSA.		mmu_circRNA_38959			obstructive sleep apnea / OSA	MONDO:0007147	obstructive sleep apnea syndrome	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_38959 is down-regulated in CIH-induced mouse liver injury and was validated by qRT-PCR. It was selected for construction of a predicted circRNA-miRNA-mRNA ceRNA network, but specific miRNAs/mRNAs for this circRNA were not detailed and predicted interactions lacked experimental validation."	0.3684
40320447	Scientific reports	2025	Characterization of circRNA expression profiles and functional roles in a mouse model of liver injury induced by OSA.		mmu_circRNA_38398			obstructive sleep apnea / OSA	MONDO:0007147	obstructive sleep apnea syndrome	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_38398 is down-regulated in CIH-induced mouse liver injury and was validated by qRT-PCR. It was used to build a predicted circRNA-miRNA-mRNA ceRNA network, but the paper did not specify its individual miRNA partners and did not experimentally validate predicted targeting."	0.3684
40320447	Scientific reports	2025	Characterization of circRNA expression profiles and functional roles in a mouse model of liver injury induced by OSA.		mmu_circRNA_25178			obstructive sleep apnea / OSA	MONDO:0007147	obstructive sleep apnea syndrome	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_25178 is down-regulated in CIH-induced mouse liver injury and was validated by qRT-PCR, but the study did not report specific interacting miRNAs/mRNAs or functional assays for this circRNA."	0.3684
40321703	Molecular biology research communications	2025	Expression patterns of circRFX3 and miR-587 in colorectal cancer patients.	hsa_circ_0001836	circRFX3 / hsa_circRFX3_003	hsa_circ_RFX3	RFX3	Colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	circRFX3 is down-regulated in peripheral blood lymphocytes/blood of CRC patients and negatively correlates with miR-587. The study suggests circRFX3 may act as a sponge for miR-587 (supported by circinteractome prediction) and has potential diagnostic value for CRC (AUC 0.66).	0.459
40324455	"Journal of neurological surgery. Part A, Central European neurosurgery"	2026	"Exosome-Derived circ0009910 Promotes Pituitary Adenoma Cell Proliferation, Invasion, Migration, and EMT through the miR-106b-5p/STAT3 Axis."	rno_circ_0009910	circ0009910 / circ_0009910			pituitary adenoma / PA	MONDO:0006373	pituitary gland adenoma	up-regulated	RT-qPCR	"Exosome-derived circ0009910 is up-regulated in serum exosomes of pituitary adenoma patients (especially invasive PA) and promotes PA progression. Mechanistically, it sponges miR-106b-5p to relieve repression of STAT3, enhancing proliferation, invasion/migration, GH secretion, and EMT; knockdown suppresses xenograft tumor growth."	0.7132
40329943	Genes & diseases	2025	CircAkap7: A novel circular RNA with a role in Doxorubicin-induced cardiotoxicity.	mmu_circ_0000153	circAkap7	mmu_circ_Akap7	Akap7	DOX-induced cardiotoxicity	MONDO:0004994	cardiomyopathy	up-regulated	RT-qPCR; RNA-seq	"circAkap7 (mmu_circ_0000153), derived from Akap7, is up-regulated in Doxorubicin-induced cardiotoxicity models and mainly localizes to the cytoplasm. It functions as an endogenous cardioprotective circRNA, where its knockdown increases Dox-induced cardiomyocyte apoptosis. Mechanistically, it is implicated in a ceRNA network involving mmu-miR-93-5p, mmu-miR-350-3p, mmu-miR-17-5p and mmu-miR-291b-3p, with a proposed key axis circAkap7/mmu-miR-291b-3p/Wee1."	0.72
40331881	The Kaohsiung journal of medical sciences	2025	Investigating the Impact of hsa_circ_0005255 on Proliferation and Autophagy in Crohn's Disease Intestinal Epithelial Cells Through miR-23a-3p-Mediated NCOA3 Expression.	hsa_circ_0005255	circMAP4	hsa_circ_MAP4	MAP4	Crohn's Disease / CD	MONDO:0005011	Crohn disease	down-regulated	RT-qPCR; Microarray	"hsa_circ_0005255 (circMAP4), derived from MAP4, is down-regulated in Crohn's disease colonic tissues and disease models. Its overexpression protects intestinal epithelial cells by sponging miR-23a-3p to increase NCOA3, thereby promoting proliferation and autophagy and reducing inflammation/apoptosis while improving barrier integrity."	0.8207
40332030	International journal of molecular sciences	2025	Extracellular Competing Endogenous RNA Networks Reveal Key Regulators of Early Amyloid Pathology Propagation in Alzheimer's Disease.		circRNA Pum1	mmu_circ_Pum1	Pum1	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RNA-seq	This study (re)analyzed public datasets to build EV/brain ceRNA networks in an APP/PSEN1 mouse model of amyloid pathology and identified circRNA Pum1 as a candidate regulator in the upregulated early-stage ceNET. The authors suggest it may represent a compensatory response during early amyloid pathology propagation.	0.31
40338386	Discover oncology	2025	Hsa-circVIM regulates breast cancer tumor progression and tamoxifen sensitivity by sponging miR-1294 in hormone receptor-positive breast cancer cells.	hsa_circ_0017873	hsa-circVIM / circVIM	hsa_circ_VIM	VIM	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"hsa-circVIM is up-regulated in breast cancer (especially HR-positive and tamoxifen-resistant cells) and is associated with poorer overall survival. Functionally, hsa-circVIM promotes malignant phenotypes and tamoxifen resistance by sponging miR-1294 (Ago2-associated), with downstream implications for targets such as MYC and TP53 and pathways including Wnt and Hippo from enrichment analyses."	0.7507
40341878	Communications biology	2025	Tumor cell-intrinsic circular RNA circFNDC3B attenuates CD8+ T cells infiltration in non-small cell lung cancer.	hsa_circ_0001361	circFNDC3B / circ0001361	hsa_circ_FNDC3B	FNDC3B	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"circFNDC3B is up-regulated in NSCLC and mainly nuclear in tumor cells. It binds TFII-I and disrupts TFII-I/STAT1 transcriptional complex formation, suppressing CXCL10/CXCL11 expression and thereby limiting CD8+ T-cell recruitment and anti-tumor immunity; high circFNDC3B associates with worse OS."	0.8907
40341878	Communications biology	2025	Tumor cell-intrinsic circular RNA circFNDC3B attenuates CD8+ T cells infiltration in non-small cell lung cancer.		circFndc3b	mmu_circ_Fndc3b	Fndc3b	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	unknown	RT-qPCR	"In the mouse LLC syngeneic model, nuclear circFndc3b binds TFII-I and interferes with TFII-I/STAT1 signaling, suppressing CXCL10/CXCL11 and limiting CD8+ T-cell infiltration. This promotes tumor growth and reduces response to anti-PD-1 therapy."	0.729
40342810	"Research (Washington, D.C.)"	2025	MiR-335-5p Escaped from CircKIAA0586 Adsorption Contributes to Mechanical Overloading-Induced Cartilage Degeneration by Targeting Lymphoid-Specific Helicase.	hsa_circ_0102233	circKIAA0586 / circ_0102233	hsa_circ_KIAA0586	KIAA0586	osteoarthritis / OA	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR	"circKIAA0586 is down-regulated in OA cartilage and in mechanically overloaded human chondrocytes. It functions as a cytoplasmic sponge for miR-335-5p, thereby preserving HELLS expression and reducing DNA-damage-associated senescence and cartilage degeneration in OA models."	0.8565
40346652	Hereditas	2025	Circ_RPPH1 promotes bladder urothelium carcinoma proliferation and EMT by recruiting and binding to EIF4 A3.		circ_RPPH1 / circ-RPPH1	hsa_circ_RPPH1	RPPH1	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circ_RPPH1 is up-regulated in bladder urothelial carcinoma and promotes tumor cell proliferation, migration/invasion and EMT. Mechanistically, circ_RPPH1 binds the RBP EIF4A3 and reduces EIF4A3 enrichment on N-cadherin and Vimentin mRNAs, increasing EMT marker expression and driving EMT."	0.7045
40353255	Animal cells and systems	2025	Circ_0081343 promotes autophagy and alleviates pyroptosis via PI3 K/AKT/HIF-1alpha axis in hypoxia-induced fetal growth restriction of mice.	mmu_circ_0081343				Fetal growth restriction / FGR	MONDO:0005030	fetal growth restriction	down-regulated	RT-qPCR	"In hypoxia-induced FGR pregnant mice, mmu_circ_0081343 is down-regulated in placental tissue. Adenoviral overexpression of mmu_circ_0081343 improves fetal/placental growth and placental histopathology by enhancing autophagy and suppressing NLRP3 inflammasome-mediated pyroptosis, involving modulation of the PI3K/AKT/HIF-1alpha signaling axis."	0.5414
40355207	Medicine	2025	Construction of a circRNA-miRNA-mRNA regulatory network in glioblastoma multiforme based on bioinformatics analysis.	hsa_circ_0001730		hsa_circ_EPHB4	EPHB4	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RNA-seq; Microarray	"hsa_circ_0001730 is predicted to be up-regulated in GBM brain tissues and included in a constructed circRNA_miRNA network, with predicted binding to hsa-miR-1182 and hsa-miR-1289, suggesting a potential regulatory role in GBM."	0.2465
40355207	Medicine	2025	Construction of a circRNA-miRNA-mRNA regulatory network in glioblastoma multiforme based on bioinformatics analysis.	hsa_circ_0019223		hsa_circ_PLCE1	PLCE1	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RNA-seq; Microarray	"hsa_circ_0019223 is predicted to be up-regulated in GBM brain tissues and incorporated into a circRNA_miRNA network, with predicted binding to hsa-miR-1208, hsa-miR-1283, hsa-miR-885-5p and hsa-miR-885-3p, suggesting a potential regulatory role in GBM."	0.2465
40355207	Medicine	2025	Construction of a circRNA-miRNA-mRNA regulatory network in glioblastoma multiforme based on bioinformatics analysis.	hsa_circ_0005114		hsa_circ_RIMS2	RIMS2	glioblastoma / GBM	MONDO:0018177	glioblastoma	down-regulated	RNA-seq; Microarray	"hsa_circ_0005114 is predicted to be down-regulated in GBM brain tissues and incorporated into a circRNA_miRNA network, with predicted binding to hsa-miR-1183, hsa-miR-1231, hsa-miR-1289, hsa-miR-139-5p and hsa-miR-346, suggesting a potential regulatory role in GBM."	0.2465
40355207	Medicine	2025	Construction of a circRNA-miRNA-mRNA regulatory network in glioblastoma multiforme based on bioinformatics analysis.	hsa_circ_0006916		hsa_circ_HOMER1	HOMER1	glioblastoma / GBM	MONDO:0018177	glioblastoma	down-regulated	RNA-seq; Microarray	"hsa_circ_0006916 is predicted to be down-regulated in GBM brain tissues and incorporated into a circRNA_miRNA network, with predicted binding to hsa-miR-1225-5p, hsa-miR-571 and hsa-miR-578, suggesting a potential regulatory role in GBM."	0.2465
40355900	Human genomics	2025	Bioinformatics analysis of circular RNAs associated with atrial fibrillation and their evaluation as predictive biomarkers.	hsa_circ_0004709	circRNA_00324			atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0004709 (circRNA_00324) is up-regulated in AF versus SR in left atrial appendage tissue and is validated by RT-qPCR. It is proposed as an independent predictor of AF based on differential expression in peripheral blood and ROC analysis (AUC 0.9138), and is included in an AF-related ceRNA network with positively correlated target mRNAs (e.g., ENOX1)."	0.5047
40355900	Human genomics	2025	Bioinformatics analysis of circular RNAs associated with atrial fibrillation and their evaluation as predictive biomarkers.		circRNA_17225			atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	up-regulated	RT-qPCR; RNA-seq	"circRNA_17225 is up-regulated in AF versus SR and validated by RT-qPCR in LAA tissue, with differential expression also confirmed in peripheral blood. It shows diagnostic potential for AF based on ROC analysis (AUC 0.7370) and is included in the AF-related ceRNA network, with positively correlated mRNAs including ANKRD33B and JAK3."	0.5047
40355900	Human genomics	2025	Bioinformatics analysis of circular RNAs associated with atrial fibrillation and their evaluation as predictive biomarkers.	hsa_circ_0134845	circRNA_16305			atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0134845 (circRNA_16305) is up-regulated in AF and validated by RT-qPCR in LAA tissue, with differential expression also confirmed in peripheral blood. It has diagnostic value for AF (AUC 0.8526) and is part of the AF-related ceRNA network with positively correlated mRNAs including ENOX1."	0.5047
40355900	Human genomics	2025	Bioinformatics analysis of circular RNAs associated with atrial fibrillation and their evaluation as predictive biomarkers.		circRNA_10233			atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	down-regulated	RT-qPCR; RNA-seq	"circRNA_10233 is down-regulated in AF versus SR and validated by RT-qPCR in LAA tissue, with differential expression also confirmed in peripheral blood and diagnostic value by ROC (AUC 0.6803). Mechanistically, it is discussed to interact with miR-223-3p and relate to autophagy via the miR-223-3p/FoxO3 target relationship within a ceRNA framework."	0.5047
40355900	Human genomics	2025	Bioinformatics analysis of circular RNAs associated with atrial fibrillation and their evaluation as predictive biomarkers.	hsa_circ_0101642	circRNA_05499			atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0101642 (circRNA_05499) is up-regulated in AF versus SR and validated by RT-qPCR in LAA tissue, with differential expression also confirmed in peripheral blood. It shows diagnostic potential for AF by ROC analysis (AUC 0.8163) and is part of the AF-related ceRNA network with positively correlated mRNAs including ANKRD33B and LBH."	0.5047
40355900	Human genomics	2025	Bioinformatics analysis of circular RNAs associated with atrial fibrillation and their evaluation as predictive biomarkers.	hsa_circ_0021506	circRNA_03183			atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0021506 (circRNA_03183) is up-regulated in AF versus SR and validated by RT-qPCR in LAA tissue, with differential expression also confirmed in peripheral blood. It has diagnostic value for AF by ROC analysis (AUC 0.8662) and is part of the AF-related ceRNA network, correlating with ENOX1, JAK3 and ECT2L expression."	0.5047
40355900	Human genomics	2025	Bioinformatics analysis of circular RNAs associated with atrial fibrillation and their evaluation as predictive biomarkers.	hsa_circ_0071616	circRNA_14211			atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0071616 (circRNA_14211) is up-regulated in AF versus SR and validated by RT-qPCR in LAA tissue, with differential expression also confirmed in peripheral blood. It has diagnostic value for AF (AUC 0.7664) and is included in the AF-related ceRNA network, correlating with ABHD18, ENOX1, CR1 and ECT2L."	0.5047
40355900	Human genomics	2025	Bioinformatics analysis of circular RNAs associated with atrial fibrillation and their evaluation as predictive biomarkers.	hsa_circ_0008038	circRNA_18422			atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0008038 (circRNA_18422) is up-regulated in AF versus SR and validated by RT-qPCR in LAA tissue, with differential expression also confirmed in peripheral blood and strong diagnostic performance by ROC (AUC 0.9320). It is discussed to interact with hsa-miR-302b-3p/hsa-miR-302c-3p and connect to atrial fibrosis via the miR-302-3p family target SDC-1 within a ceRNA framework."	0.5047
40366468	Cell biology and toxicology	2025	U2AF65 mediated circPVT1 promotes NSCLC cell proliferation and inhibits ferroptosis through the miR-338-3p/GPX4 axis.		circPVT1	hsa_circ_PVT1	PVT1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circPVT1 is up-regulated in NSCLC and associated with worse clinical outcomes. It promotes proliferation and inhibits ferroptosis by acting as a ceRNA for miR-338-3p to increase GPX4 expression, and its abundance is enhanced by the RBP U2AF65 that binds and stabilizes circPVT1."	0.8227
40367575	"Clinics (Sao Paulo, Brazil)"	2025	CircRNA-NOLC1 mediates Insulin-like growth factor 1 receptor via performing as a ceRNA of miRNA-140-5p to facilitate testicular germ cell tumor advancement.		CircRNA-NOLC1 / circNOLC1	hsa_circ_NOLC1	NOLC1	Testicular Germ Cell Tumor / TGCT	MONDO:0010108	testicular germ cell tumor	up-regulated	RT-qPCR	"circNOLC1 is up-regulated in TGCT and promotes malignant phenotypes (proliferation/colony formation/invasion) while inhibiting apoptosis. Mechanistically, it functions as a ceRNA sponging miR-140_5p to increase IGF1R expression, and its high expression is associated with more advanced clinicopathological features."	0.7945
40369698	Hereditas	2025	Mechanistic insights into Circ-MBOAT2-mediated regulation of TLK1 through miR-664b-3p in non-small cell lung cancer.		circ-MBOAT2 / circMBOAT2	hsa_circ_MBOAT2	MBOAT2	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"Circ-MBOAT2 is up-regulated in NSCLC tissues/cell lines and promotes malignant phenotypes including proliferation, EMT, migration/invasion and immune escape while suppressing apoptosis. Mechanistically, it functions as a ceRNA by sponging miR-664b-3p to increase TLK1 expression, and its knockdown suppresses tumor growth in a xenograft model."	0.8655
40373256	Autophagy	2025	CircRNA GRAMD4 induces NBR1 expression to promote autophagy and immune escape in renal cell carcinoma.	hsa_circ_0001250	circGRAMD4	hsa_circ_GRAMD4	GRAMD4	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"circGRAMD4 is up-regulated in RCC and promotes immune escape. It binds the RBP RBM4 and facilitates formation of a ternary complex with NBR1 mRNA to stabilize NBR1, thereby enhancing autophagy-dependent degradation of MHC-I, impairing antigen presentation and CD8+ T cell cytotoxicity. High circGRAMD4 associates with poor OS/PFS and its inhibition synergizes with PDCD1 blockade in PDX models."	0.8981
40373256	Autophagy	2025	CircRNA GRAMD4 induces NBR1 expression to promote autophagy and immune escape in renal cell carcinoma.	mmu_circ_0005931	circGRAMD4	mmu_circ_GRAMD4	GRAMD4	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"circGRAMD4 is up-regulated in RCC and promotes immune escape. It binds the RBP RBM4 and facilitates formation of a ternary complex with NBR1 mRNA to stabilize NBR1, thereby enhancing autophagy-dependent degradation of MHC-I, impairing antigen presentation and CD8+ T cell cytotoxicity. High circGRAMD4 associates with poor OS/PFS and its inhibition synergizes with PDCD1 blockade in PDX models."	0.8981
40374541	Journal of microbiology and biotechnology	2025	Development and Evaluation of a Droplet Digital PCR Assay for the Accurately Detecting the CircHIPK3 in Plasma Samples from Patients with Hepatocellular Carcinoma.	hsa_circ_0000284	CircRNA HIPK3 / circHIPK3	hsa_circ_HIPK3	HIPK3	Hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circHIPK3 (hsa_circ_0000284) is up-regulated in HCC patient plasma and in HCC cell lines (HepG2, Huh7) versus normal liver cells (LX-2). This study develops and benchmarks a ddPCR assay (vs RT-qPCR) to sensitively quantify plasma circHIPK3, supporting its use as a liquid-biopsy biomarker candidate for HCC."	0.6605
40376950	Journal of clinical laboratory analysis	2025	Expression Profile of Serum CircFUNDC1 and CircUHRF1 Can Differentiate Between Colorectal Cancer and Inflammatory Bowel Diseases (Ulcerative Colitis and Crohn's Disease).		CircFUNDC1 / Circular RNA FUNDC1 (CircFUNDC1)	hsa_circ_FUNDC1	FUNDC1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"Serum CircFUNDC1 is up-regulated in CRC as well as UC and CD compared with healthy controls. It shows good diagnostic performance by ROC analysis for distinguishing CRC/IBD from controls and CRC from UC/CD, supporting its use as a non-invasive biomarker (especially for CRC)."	0.4187
40376950	Journal of clinical laboratory analysis	2025	Expression Profile of Serum CircFUNDC1 and CircUHRF1 Can Differentiate Between Colorectal Cancer and Inflammatory Bowel Diseases (Ulcerative Colitis and Crohn's Disease).		CircUHRF1	hsa_circ_UHRF1	UHRF1	ulcerative colitis / UC	MONDO:0005101	ulcerative colitis	up-regulated	RT-qPCR	"CircUHRF1 is up-regulated in serum of UC and CD patients, supporting its use as an IBD biomarker and for distinguishing IBD from CRC and healthy controls. The study does not provide direct functional/mechanistic validation; mechanistic explanations are discussed based on its host gene UHRF1 and prior literature."	0.4187
40385694	Oncology letters	2025	Distinguishing acute leukemia subtypes: The role of hsa_circ_0012152 and hsa_circ_0020093 in peripheral blood.	hsa_circ_0012152				acute leukemia / AL	MONDO:0010643	acute leukemia	dysregulated	RT-qPCR; Microarray	"hsa_circ_0012152 is differentially expressed in peripheral blood PBMCs, with higher levels in AML than in ALL and normal controls. It shows strong diagnostic performance for AML and helps discriminate AML from ALL, including specific subtype-related discrimination within AML and ALL."	0.5047
40385694	Oncology letters	2025	Distinguishing acute leukemia subtypes: The role of hsa_circ_0012152 and hsa_circ_0020093 in peripheral blood.	hsa_circ_0020093				acute leukemia / AL	MONDO:0010643	acute leukemia	up-regulated	RT-qPCR; Microarray	"hsa_circ_0020093 is upregulated in ALL peripheral blood PBMCs compared with AML and controls and shows diagnostic utility for ALL and AML/ALL discrimination. Mechanistically, the study predicts a ceRNA network where hsa_circ_0020093 sponges miRNAs (notably hsa-miR-153-3p and hsa-miR-194-5p) to affect downstream genes and potentially promote MAPK and mTOR signaling in ALL."	0.5047
40386233	PeerJ	2025	Has_circRNA_0122683 (circ-PRKCI) relieves ferroptosis of HPAEpiCs in sepsis-induced acute lung injury by sponging miR-382-5p.	hsa_circ_0122683	circ-PRKCI	hsa_circ_PRKCI	PRKCI	sepsis-induced acute lung injury	MONDO:0015796	acute lung injury	down-regulated	RT-qPCR	"circ-PRKCI is down-regulated in septic ALI patient plasma and in LPS-treated HPAEpiCs. Its overexpression protects HPAEpiCs by suppressing ferroptosis and inflammatory cytokine release, mainly by sponging and negatively regulating miR-382-5p. circ-PRKCI shows strong diagnostic potential for septic ALI based on ROC analysis."	0.8213
40386902	Cancer science	2025	Hypoxia Inhibitor Improves Iodine Uptake Disorder in Thyroid Cancer Through the hsa_circ_0023990/miR-448/DNMT1/NIS Axis.	hsa_circ_0023990				thyroid cancer / TC	MONDO:0002108	thyroid cancer	up-regulated	RT-qPCR	"hsa_circ_0023990 is up-regulated in DTC and further elevated in RAIR-DTC, where it reduces iodine uptake by repressing NIS. Mechanistically, it acts as a ceRNA for miR-448 to increase DNMT1, which promotes NIS promoter methylation and decreases NIS expression. The HIF-1alpha inhibitor BAY87-2243 downregulates hsa_circ_0023990, restoring NIS expression, improving iodine uptake, and inhibiting xenograft tumor growth."	0.7992
40387410	The Kaohsiung journal of medical sciences	2025	Circ_0006646 Promotes the Progression of Osteoarthritis via Upregulating CDH11 Expression in an IGF2BP2-Dependent Manner.	hsa_circ_0006646	circ_0006646	hsa_circ_PTK2	PTK2	Osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circ_0006646 is up-regulated in OA cartilage and in IL-1beta-stimulated human chondrocytes. Functionally, circ_0006646 promotes IL-1beta-induced chondrocyte injury (reduced proliferation, increased apoptosis/inflammation and ECM degradation) by binding IGF2BP2 and enhancing IGF2BP2-dependent stabilization and upregulation of CDH11."	0.7009
40395717	Food science & nutrition	2025	"Amaranthus spinosus Linn. Extract as an Innovative Strategy to Regulate Biomarkers for Ovarian Hyperthecosis via Circular RNA (hsa-circ-0001577): Evidence From Biochemical, Metabolomics, Histological, and Phytochemical Profiling."	hsa_circ_0001577				ovarian hyperthecosis	MONDO:0004194	ovarian stromal hyperthecosis	up-regulated	RT-qPCR	"In a DHEA-induced rat ovarian hyperthecosis model, hsa-circ-0001577 was significantly increased in serum and was reduced after Amaranthus spinosus EtOH extract treatment, suggesting it is a modulated biomarker associated with disease status and treatment response."	0.2586
40400020	Journal of translational medicine	2025	CircPRDM5-mediated regulation of miR-433-3p and HDAC6 in Parkinson's disease: a novel neuroprotective axis.		circPRDM5 / hsa_circRNA_103730	hsa_circ_PRDM5	PRDM5	Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	up-regulated	RT-qPCR	"circPRDM5 is up-regulated in PD patient blood and in toxin-induced PD models. It mainly localizes to the cytoplasm and acts as a miRNA sponge for miR-433-3p, thereby increasing HDAC6 expression and promoting neuronal injury with increased apoptosis and autophagy; circPRDM5 knockdown is protective in SH-SY5Y cells and MPTP mice."	0.8635
40405299	Hereditas	2025	"Hsa_circ_0006837 suppresses gastric cancer cell proliferation, migration, and invasion via the modulation of miR-424-5p."	hsa_circ_0006837	circRERE	hsa_circ_RERE	RERE	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"hsa_circ_0006837 (circRERE) is downregulated in gastric cancer and higher expression predicts better overall survival. Functionally, its overexpression suppresses GC cell proliferation, migration, and invasion by targeting miR-424-5p and upregulating the downstream gene FBXO21."	0.7283
40414884	BMC microbiology	2025	The mechanism of ECT1/E6E7 cervical intraepithelial neoplasia cells regulated by Acinetobacter lwoffii through circ-LDHA/HMGB1.	hsa_circ_0021451	circ-LDHA / hsa_circ_0021451-284	hsa_circ_LDHA	LDHA	cervical intraepithelial neoplasia / CIN	MONDO:0022394	cervical intraepithelial neoplasia	up-regulated	RT-qPCR	"circ-LDHA is upregulated in CIN and cervical cancer cervical tissues and is induced in ECT1/E6E7 cells after Acinetobacter lwoffii coculture. The study links increased circ-LDHA (predicted to bind miR-34a) with increased HMGB1 expression and with pro-proliferative, pro-migratory and anti-apoptotic phenotypes in HPV-associated cervical precancerous cells."	0.568
40416363	"Research (Washington, D.C.)"	2025	Targeting the Exonic Circular OGT RNA/O-GlcNAc Transferase/Forkhead Box C1 Axis Inhibits Asparagine- and Alanine-Mediated Ferroptosis Repression in Neuroblastoma Progression.	hsa_circ_0091037	exonic circular OGT RNA / ecircOGT	hsa_circ_OGT	OGT	neuroblastoma / NB	MONDO:0005072	neuroblastoma	down-regulated	RT-qPCR	"In neuroblastoma, ecircOGT is down-regulated and functions as a tumor-suppressive circRNA by encoding OGT-570aa. OGT-570aa competitively binds FOXC1 to disrupt the OGT_FOXC1 interaction, decreasing FOXC1-driven ASNS/GPT2 expression and asparagine/alanine-mediated ferroptosis resistance, thereby inhibiting tumor growth and aggressiveness."	0.8791
40427349	Animals : an open access journal from MDPI	2025	Preliminary Study of Differential circRNA Expression and Investigation of circRNA-miRNA-mRNA Competitive Endogenous Network in Rumen Acidosis of Holstein Cattle.		circRNA 8:69996068-69996853 	bta_circ_BMP1	BMP1	subacute ruminal acidosis / SARA	MONDO:0000440	metabolic acidosis	up-regulated	RNA-seq	"circRNA 8:69996068-69996853 (host gene BMP1) is a hub DE-circRNA up-regulated in SARA rumen tissue and participates in a circRNA_miRNA_mRNA ceRNA network. It is implicated in immune/inflammatory and metabolic regulation, potentially involving NF-kappaB-related inflammatory signaling via miRNA-mediated targeting of immune-related mRNAs."	0.31
40427349	Animals : an open access journal from MDPI	2025	Preliminary Study of Differential circRNA Expression and Investigation of circRNA-miRNA-mRNA Competitive Endogenous Network in Rumen Acidosis of Holstein Cattle.		circRNA 16:2614111-2615445	bta_circ_NFACS	NFACS	subacute ruminal acidosis / SARA	MONDO:0000440	metabolic acidosis	unknown	RNA-seq	"circRNA 16:2614111-2615445 (host gene NFACS) is highlighted as a hub circRNA in the SARA ceRNA network in rumen tissue, suggesting involvement in immune/inflammatory and metabolic adaptation processes through miRNA sponging and downstream mRNA regulation. The study does not explicitly report its up/down direction in the provided text excerpt."	0.31
40427349	Animals : an open access journal from MDPI	2025	Preliminary Study of Differential circRNA Expression and Investigation of circRNA-miRNA-mRNA Competitive Endogenous Network in Rumen Acidosis of Holstein Cattle.		circRNA 5:109525933-109531380	bta_circ_CECR2	CECR2	subacute ruminal acidosis / SARA	MONDO:0000440	metabolic acidosis	down-regulated	RNA-seq	"circRNA 5:109525933-109531380 (host gene CECR2) is down-regulated in SARA rumen tissue and identified as a hub circRNA in the constructed ceRNA network. It may influence inflammatory and metabolic processes, potentially linked to NF-kappaB-related inflammation and lipid/inflammation interplay via miRNA-mediated regulation of immune/metabolic target genes."	0.31
40427349	Animals : an open access journal from MDPI	2025	Preliminary Study of Differential circRNA Expression and Investigation of circRNA-miRNA-mRNA Competitive Endogenous Network in Rumen Acidosis of Holstein Cattle.		circRNA 20:63115665-63116774	bta_circ_FAM173B	FAM173B	subacute ruminal acidosis / SARA	MONDO:0000440	metabolic acidosis	up-regulated	RNA-seq	"circRNA 20:63115665-63116774 (host gene FAM173B) is up-regulated in SARA rumen tissue and is one of the hub circRNAs highlighted by network analyses. The paper links hub circRNAs (including this one) to inflammation and epithelial function through host-gene transcription-factor associations, but does not provide a specific miRNA/mRNA axis for this circRNA in the provided text."	0.31
40429981	International journal of molecular sciences	2025	"Preliminary Evaluation of Plasma circ_0009910, circ_0027478, and miR-1236-3p as Diagnostic and Prognostic Biomarkers in Hepatocellular Carcinoma."	hsa_circ_0009910	circ_0009910 / circ-0009910	hsa_circ_MFN2	MFN2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"Plasma circ_0009910 is significantly up-regulated in HCC patients and shows strong diagnostic performance versus healthy controls. Its higher levels are associated with more aggressive clinicopathological features (larger tumor size, advanced stage, metastasis, higher AFP), supporting its use as a non-invasive diagnostic/prognostic biomarker, though functional mechanisms were not experimentally validated."	0.559
40429981	International journal of molecular sciences	2025	"Preliminary Evaluation of Plasma circ_0009910, circ_0027478, and miR-1236-3p as Diagnostic and Prognostic Biomarkers in Hepatocellular Carcinoma."	hsa_circ_0027478	circ_0027478	hsa_circ_NUP107	NUP107	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"Plasma circ_0027478 is significantly up-regulated in HCC and has moderate diagnostic/prognostic value, including distinguishing metastatic from non-metastatic cases. Bioinformatics suggests it is cytoplasmic and may act as a miRNA sponge for miR-1236-3p, potentially impacting the AFP/PTEN/PI3K-Akt axis, but this mechanism was not experimentally validated in the study."	0.559
40437145	Cell biology and toxicology	2025	The key regulator circPDE3B promotes arsenic-induced bladder carcinogenesis by affecting STAT3 and NF-kappaB stability.	hsa_circ_0000277	circPDE3B	hsa_circ_PDE3B	PDE3B	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; RNA-seq	"circPDE3B is up-regulated during chronic arsenic (NaAsO2)-induced malignant transformation of SV-HUC-1 cells and promotes proliferation while inhibiting apoptosis. Mechanistically, circPDE3B directly binds NF-kappaB and STAT3, reduces their ubiquitination to stabilize these proteins, and thereby elevates HIF-1alpha signaling to drive arsenic-induced bladder carcinogenesis."	0.8036
40437586	Journal of cardiothoracic surgery	2025	The role of circ_0050908 in acute myocardial infarction (AMI) and its predictive value for AMI.	hsa_circ_0050908	circ_0050908			acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR	"circ_0050908 is up-regulated in the serum of AMI patients and in AC16 cardiomyocytes after hypoxia/reoxygenation. Knockdown of circ_0050908 protects cardiomyocytes from H/R-induced injury by increasing viability and reducing apoptosis, myocardial injury markers, and inflammatory cytokines, at least partly via targeting/negatively regulating miR-338-3p. circ_0050908 shows diagnostic potential for AMI (AUC 0.885) and is a risk factor in logistic regression."	0.8323
40446676	Poultry science	2025	CircRALGPS2 modulates chicken follicle development through promotion of granulosa cell apoptosis and autophagy via the miR-200a-3p/TGFbeta2/SMAD pathway.		circRALGPS2	gga_circ_RALGPS2	RALGPS2	follicular atresia	MONDO:0005558	ovarian disorder	up-regulated	RT-qPCR; RNA-seq	"circRALGPS2 is up-regulated in atretic chicken follicles and promotes follicular atresia by increasing granulosa cell apoptosis and autophagy. It acts as a ceRNA by sponging miR-200a-3p to relieve repression of TGFbeta2, thereby activating the canonical TGFbeta/SMAD pathway (p-SMAD2/3) and elevating apoptosis/autophagy markers."	0.8454
40448098	BMC cancer	2025	CircSLC22A3 inhibits the invasion and metastasis of ESCC via the miR-19b-3p/TRAK2 axis and by reducing the stability of m6A-modified ACSBG1 mRNA.	hsa_circ_0078607	circSLC22A3	hsa_circ_SLC22A3	SLC22A3	Esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	RT-qPCR; ISH; RNA-seq	"circSLC22A3 is down-regulated in ESCC and acts as a tumor suppressor by inhibiting migration, invasion, and lung metastasis. Mechanistically, it sponges miR-19b-3p to increase TRAK2 expression and also binds IGF2BP1 to reduce m6A-dependent ACSBG1 mRNA stability, decreasing ACSBG1 and suppressing metastatic behavior. Low circSLC22A3 expression is associated with shorter overall survival in ESCC patients."	0.8767
40448136	Journal of translational medicine	2025	RNA profiling and immunohistochemistry analyses of circRNAs in imatinib-resistant gastrointestinal stromal tumors.	hsa_circ_0081518	circ-EPHB4 / circ_0081518	hsa_circ_EPHB4	EPHB4	Gastrointestinal stromal tumor / GIST	MONDO:0011719	gastrointestinal stromal tumor	up-regulated	RT-qPCR; ISH; Microarray	circ-EPHB4 (circ_0081518) is upregulated in imatinib-resistant GIST tumor tissues and correlates with imatinib resistance and clinical aggressiveness (relapse/progression/metastasis). It is detectable by ISH with predominant nuclear staining in high-grade malignant tumor cells and shows diagnostic/prognostic relevance in ROC/Kaplan_Meier analyses.	0.7277
40448136	Journal of translational medicine	2025	RNA profiling and immunohistochemistry analyses of circRNAs in imatinib-resistant gastrointestinal stromal tumors.	hsa_circ_0045015	circ-BRIP1 / circ_0045015	hsa_circ_BRIP1	BRIP1	Gastrointestinal stromal tumor / GIST	MONDO:0011719	gastrointestinal stromal tumor	up-regulated	RT-qPCR; ISH; Microarray	"circ-BRIP1 (circ_0045015) is upregulated in imatinib-resistant GIST tissues and correlates with resistance and aggressive clinical features (relapse/progression/metastasis). ISH shows nucleus/cytoplasm positivity in malignant tumor cells, and high circ-BRIP1 expression is associated with worse survival."	0.7277
40448136	Journal of translational medicine	2025	RNA profiling and immunohistochemistry analyses of circRNAs in imatinib-resistant gastrointestinal stromal tumors.	hsa_circ_0086139	circ-RECQL4 / circ_0086139	hsa_circ_RECQL4	RECQL4	Gastrointestinal stromal tumor / GIST	MONDO:0011719	gastrointestinal stromal tumor	up-regulated	RT-qPCR; Microarray	circ-RECQL4 (circ_0086139) is upregulated in imatinib-resistant GIST tissues and has ROC-based diagnostic value for distinguishing resistant from imatinib-na_ve tumors. The paper does not report a specific molecular mechanism or subcellular localization for this circRNA.	0.6605
40453910	Avicenna journal of medical biotechnology	2025	Exploring the Role of hsa_circ_0052112 as a Potential Biomarker in Breast Cancer: Insights from Experimental and In Silico Analyses.	hsa_circ_0052112		hsa_circ_ZNF83	ZNF83	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"hsa_circ_0052112 is up-regulated in breast cancer tumor tissue and plasma and is associated with advanced stage and lymph node involvement, supporting its potential as a diagnostic/prognostic biomarker. In silico analyses suggest it may act through a ceRNA network involving miR-194 and hub genes (MAPK1, STAT1, TRAF6, ERRB4) with enrichment in PI3K/AKT-related processes, and it is predicted to bind RBPs such as AGO2, EIF4A3 and PTB."	0.348
40455824	PLoS genetics	2025	ciRS-7 expression is epigenetically regulated in cancer cells across human adenocarcinomas.		ciRS-7 / CDR1as	hsa_circ_LINC00632	LINC00632	adenocarcinoma	MONDO:0004970	adenocarcinoma	dysregulated	RT-qPCR; ISH; Microarray	"This study shows that ciRS-7 (CDR1as) is largely absent from adenocarcinoma cancer cells but present in stromal/TME compartments, with exceptions such as many breast tumor specimens. Its expression is epigenetically regulated, primarily through DNA methylation and H3K9 acetylation at the LINC00632 T3 promoter, and can be reactivated in vitro using demethylating and HDAC-inhibitor treatments."	0.6428
40457486	Stem cell research & therapy	2025	circ_0002456/FUS interaction inhibits NF-kappaB signaling to attenuate DNA damage and inflammatory responses in hDPSCs.	hsa_circ_0002456	circ_0002456	hsa_circ_DOCK1	DOCK1	pulpitis	MONDO:0006937	pulpitis	down-regulated	RT-qPCR; RNA-seq	"circ_0002456 is down-regulated in pulpitis and in LPS-stimulated hDPSCs. It binds the RBP FUS, limits FUS nuclear export, and suppresses NF-kappaB activation, thereby reducing DNA damage (gamma-H2AX) and inflammatory cytokine expression; overexpression also attenuates these responses in a mouse pulpitis model."	0.7929
40458373	bioRxiv : the preprint server for biology	2025	CircRNA hypomethylation in the human amygdala implicates FKBP5 in alcohol use disorder.		circFKBP5_1 / hsa_circRNA_076155	hsa_circ_FKBP5	FKBP5	alcohol use disorder / AUD	MONDO:0002046	alcohol abuse	up-regulated	RT-qPCR; Microarray	"circFKBP5_1 is hypomethylated (m6A) and up-regulated in AUD basolateral amygdala. It is part of a predicted ceRNA network with miR-561_5p/miR-708_5p/miR-642a-5p targeting neurodevelopment-related genes, and circFKBP5 changes correlate with increased FKBP5 mRNA isoform expression."	0.5922
40458373	bioRxiv : the preprint server for biology	2025	CircRNA hypomethylation in the human amygdala implicates FKBP5 in alcohol use disorder.		circFKBP5_2 / hsa_circRNA_104101	hsa_circ_FKBP5	FKBP5	alcohol use disorder / AUD	MONDO:0002046	alcohol abuse	up-regulated	RT-qPCR; Microarray	"circFKBP5_2 is hypomethylated (m6A) and up-regulated in AUD basolateral amygdala. It is included in a predicted circFKBP5_miRNA_mRNA network (miR-561_5p/miR-708_5p/miR-642a-5p) enriched for neurodevelopmental targets, and circFKBP5 alterations correlate with increased FKBP5 mRNA isoform expression."	0.5922
40458373	bioRxiv : the preprint server for biology	2025	CircRNA hypomethylation in the human amygdala implicates FKBP5 in alcohol use disorder.		circFKBP5_3 / hsa_circRNA_406761	hsa_circ_FKBP5	FKBP5	alcohol use disorder / AUD	MONDO:0002046	alcohol abuse	up-regulated	RT-qPCR; Microarray	"circFKBP5_3 is significantly hypomethylated (m6A) and up-regulated in AUD basolateral amygdala, and its changes track with increased FKBP5 mRNA isoform expression at the group (circFKBP5s) level. No specific miRNA interaction network was reported for circFKBP5_3."	0.4773
40458373	bioRxiv : the preprint server for biology	2025	CircRNA hypomethylation in the human amygdala implicates FKBP5 in alcohol use disorder.		circFkbp5_1r / rno-Fkbp5_0003	rno_circ_Fkbp5	Fkbp5	alcohol dependence	MONDO:0007079	alcohol dependence	up-regulated	RT-qPCR	"In the alcohol-dependent rat model, circFkbp5_1r is hypomethylated (m6A) and up-regulated in BLA, consistent with human AUD findings and supporting a link between circFkbp5 methylation state and Fkbp5 expression changes."	0.3956
40458373	bioRxiv : the preprint server for biology	2025	CircRNA hypomethylation in the human amygdala implicates FKBP5 in alcohol use disorder.		circFkbp5_2r / rno-Fkbp5_0006	rno_circ_Fkbp5	Fkbp5	alcohol dependence	MONDO:0007079	alcohol dependence	up-regulated	RT-qPCR	"In the alcohol-dependent rat model, circFkbp5_2r is hypomethylated (m6A) and up-regulated in BLA, matching the human AUD pattern and consistent with involvement of circFkbp5 methylation in Fkbp5 expression changes."	0.3956
40464594	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2025	CircTP53/USP10/p53 signaling Axis as a Novel Regulator of Progression and Prognosis of Head and Neck Squamous Cell Carcinoma.	hsa_circ_0041947	circTP53	hsa_circ_TP53	TP53	head and neck squamous cell carcinoma / HNSCC	MONDO:0010150	head and neck squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circTP53 (hsa-circ-0041947) is up-regulated in HNSCC and high expression is associated with poor overall survival. It binds USP10 (via partial intron 9) and mutually stabilizes USP10, enhancing USP10-mediated deubiquitination and stabilization of p53, thereby modulating HNSCC progression in a p53-mutation-status-dependent manner."	0.8829
40464594	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2025	CircTP53/USP10/p53 signaling Axis as a Novel Regulator of Progression and Prognosis of Head and Neck Squamous Cell Carcinoma.	hsa_circ_0041946		hsa_circ_TP53	TP53	head and neck squamous cell carcinoma / HNSCC	MONDO:0010150	head and neck squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa-circ-0041946 is up-regulated in HNSCC tissues but is not correlated with prognosis. It can interact with USP10 (shown by exogenous RIP) and is stabilized by USP10, but it does not reciprocally increase USP10 levels."	0.5135
40466438	"Clinics (Sao Paulo, Brazil)"	2025	CircHIPK3's dual role in promoting angiogenesis and inhibiting apoptosis through FASN mRNA stabilization in gallbladder cancer.	hsa_circ_0000284	circHIPK3 / circRNA Homeodomain-Interacting Protein Kinase 3	hsa_circ_HIPK3	HIPK3	Gallbladder cancer / GBC	MONDO:0005411	gallbladder cancer	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in gallbladder cancer and promotes malignant phenotypes (proliferation, migration/invasion, angiogenesis) while inhibiting apoptosis. Mechanistically, it binds and stabilizes the RBP ALYREF by reducing its ubiquitination, which in turn stabilizes FASN mRNA and increases FASN expression, driving angiogenesis and anti-apoptotic effects."	0.8635
40473597	Cell death & disease	2025	Circular RNA TFRC/SCD1 mRNA interaction regulates ferroptosis and metastasis in gastric cancer.	hsa_circ_0068606	circTFRC / hsa_circRNA_103554	hsa_circ_TFRC	TFRC	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circTFRC is upregulated in gastric cancer tissues, cell lines, and patient plasma, and its higher plasma level correlates with tumor size and distant metastasis. Functionally, circTFRC promotes GC proliferation and metastasis and suppresses ferroptosis by directly binding SCD1 mRNA and recruiting ELAVL1 to increase SCD1 mRNA stability/translation, supporting lipid metabolic reprogramming."	0.8837
40476021	Non-coding RNA research	2025	Circ_0054633 silencing suppresses hyperglycemia-induced extracellular matrix accumulation in renal mesangial cells by regulating MiR-136-5p/SMAD3 signaling.	hsa_circ_0054633		hsa_circ_PNPT1	PNPT1	diabetic kidney disease / DKD	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"circ_0054633 is up-regulated in DKD (patient serum, HG-stimulated HRMCs, and db/db mice). It promotes mesangial cell proliferation and ECM accumulation by sponging miR-136-5p to increase SMAD3 and activate TGF-beta1/SMAD3 signaling; silencing circ_0054633 alleviates renal fibrosis and improves renal function in vivo."	0.7365
40476021	Non-coding RNA research	2025	Circ_0054633 silencing suppresses hyperglycemia-induced extracellular matrix accumulation in renal mesangial cells by regulating MiR-136-5p/SMAD3 signaling.			mmu_circ_PNPT1	PNPT1	diabetic kidney disease / DKD	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"circ_0054633 is up-regulated in DKD (patient serum, HG-stimulated HRMCs, and db/db mice). It promotes mesangial cell proliferation and ECM accumulation by sponging miR-136-5p to increase SMAD3 and activate TGF-beta1/SMAD3 signaling; silencing circ_0054633 alleviates renal fibrosis and improves renal function in vivo."	0.7365
40481048	Scientific reports	2025	CircRNA_1809 promotes the osteogenic differentiation of bone marrow mesenchymal stem cells through miR-370-3p.		CircRNA_1809 / circ_1809			bone defects / bone defect repair	MONDO:0005497	bone development disease	up-regulated	RT-qPCR	"circRNA_1809 is up-regulated during osteogenic differentiation of rat BMMSCs and promotes osteogenesis. Mechanistically, it functions as a ceRNA by sponging miR-370-3p, thereby relieving repression of Kitlg and increasing osteogenic markers (ALP, RUNX2), with a proposed involvement of PI3K/Akt signaling downstream of Kitlg."	0.5416
40487353	Molecular therapy. Nucleic acids	2025	CircITSN1/EIF4A3/Itsn1 axis mediates postoperative cognitive dysfunction in aged mice: A novel mechanism and therapeutic target.			hsa_circ_ITSN1	ITSN1	postoperative cognitive dysfunction / POCD	MONDO:0002602	central nervous system disorder	up-regulated	Microarray	hsa_circRNA_061570 was identified by circRNA microarray as upregulated in POCD patient plasma/serum and correlated with cognitive decline. Bioinformatic prediction suggests it has protein-binding capacity to EIF4A3.	0.1768
40487353	Molecular therapy. Nucleic acids	2025	CircITSN1/EIF4A3/Itsn1 axis mediates postoperative cognitive dysfunction in aged mice: A novel mechanism and therapeutic target.			mmu_circ_Itsn1	Itsn1	postoperative cognitive dysfunction / POCD	MONDO:0002602	central nervous system disorder	up-regulated	RT-qPCR; ISH	"circITSN1 is upregulated in hippocampus and serum in an aged mouse POCD model and promotes cognitive impairment and dendritic spine injury. It binds EIF4A3 to enhance Itsn1 mRNA stability, increasing ITSN1 and activating JNK-mediated neuroinflammation; knockdown of circITSN1 improves behavioral and synaptic outcomes."	0.7759
40487959	World journal of gastrointestinal oncology	2025	Circular RNA hsa_circRNA_101996 modulates gastric cancer cell proliferation and apoptosis through the miR-577/HMGN5 axis.		hsa_circRNA_101996 / circRNA_101996			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"In gastric cancer, hsa_circRNA_101996 is up-regulated and promotes cell proliferation while inhibiting apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-577, thereby increasing HMGN5 expression and enhancing tumor growth in a nude-mouse xenograft model."	0.6815
40500263	Cell death & disease	2025	Tumor exosomal circPTBP3 drives gastric cancer peritoneal metastasis via mesothelial-mesenchymal transition.		circPTBP3 / circPTPB3	hsa_circ_PTBP3	PTBP3	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"Exosomal circPTBP3 is up-regulated in gastric cancer patients with peritoneal metastasis and promotes mesothelial-mesenchymal transition and peritoneal fibrosis, facilitating peritoneal metastasis. Mechanistically, nuclear circPTBP3 recruits TFAP2B to SGK1 promoter regions to activate SGK1 transcription. Plasma exosomal circPTBP3 shows diagnostic value for GCPM and high levels predict poorer overall survival."	0.8939
40500346	NPJ precision oncology	2025	"Genome-wide analyses identify circAQR, a circular RNA suppressing proliferation but promoting migration and invasion in thyroid cancer."		circAQR	hsa_circ_AQR	AQR	thyroid cancer / TC	MONDO:0002108	thyroid cancer	down-regulated	RT-qPCR; RNA-seq	"circAQR is down-regulated in thyroid cancer tissues and cell lines versus adjacent/normal controls. Functionally, circAQR suppresses proliferation but promotes migration and invasion in thyroid cancer cells. The study proposes a miRNA-linked mechanism (potentially via hsa-miR-6730-5p and Wnt signaling/autophagy) and suggests circAQR is associated with tumor size and lymph node metastasis."	0.7046
40504123	The Kaohsiung journal of medical sciences	2025	Mechanistic Insights Into hsa_circ_0005654-Induced Ferroptosis in Diabetic Foot Ulcers Through IGF2BP2 Interaction.	hsa_circ_0005654	circ_0005654			Diabetic foot ulcer / DFU	MONDO:0005015	diabetes mellitus	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005654 (circ_0005654) is up-regulated in DFU and aggravates wound healing impairment by promoting ferroptosis and inflammation. Mechanistically, it binds the RBP IGF2BP2 and positively regulates IGF2BP2 expression, and IGF2BP2 overexpression attenuates the effects of circ_0005654 knockdown in DFU rats."	0.7283
40513658	Journal of advanced research	2026	A novel peptide MIB1-223aa encoded by exosomal circMIB1 from cancer-associated fibroblasts drives triple-negative breast cancer metastasis and stemness via stabilizing MIB1 to activate Notch signaling.	hsa_circ_0000835	circMIB1	hsa_circ_MIB1	MIB1	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circMIB1 is enriched in CAF-derived exosomes and transferred to TNBC cells, where it is translated into the peptide MIB1-223aa. MIB1-223aa competitively binds RNF213 to reduce K48-linked ubiquitination of MIB1, stabilizing MIB1 and activating DLL4-dependent Notch signaling, thereby promoting TNBC EMT/metastasis and stemness and associating with poor prognosis."	0.8986
40520523	Toxicology reports	2025	"Assembled human microbiome and metabolome in chronic kidney disease: Dysbiosis a double-edged sword interlinking Circ-YAP1, Circ-APOE & Circ-SLC8A1."		Circ-YAP1	hsa_circ_YAP1	YAP1	chronic kidney disease / CKD	MONDO:0005300	chronic kidney disease	up-regulated	RT-qPCR	"Circ-YAP1 is up-regulated in CKD patient serum. The study links its altered expression with mTOR/autophagy marker changes and correlations with renal function clinical indices, suggesting potential biomarker relevance for CKD diagnosis/prognosis."	0.4128
40520523	Toxicology reports	2025	"Assembled human microbiome and metabolome in chronic kidney disease: Dysbiosis a double-edged sword interlinking Circ-YAP1, Circ-APOE & Circ-SLC8A1."		Circ-APOE	hsa_circ_APOE	APOE	chronic kidney disease / CKD	MONDO:0005300	chronic kidney disease	up-regulated	RT-qPCR	"Circ-APOE is up-regulated in CKD patient serum. Its altered level is reported alongside mTOR/autophagy marker alteration and correlates with renal function clinical indices, supporting potential biomarker utility for CKD diagnosis/prognosis."	0.4128
40520523	Toxicology reports	2025	"Assembled human microbiome and metabolome in chronic kidney disease: Dysbiosis a double-edged sword interlinking Circ-YAP1, Circ-APOE & Circ-SLC8A1."		Circ-SLC8A1	hsa_circ_SLC8A1	SLC8A1	chronic kidney disease / CKD	MONDO:0005300	chronic kidney disease	down-regulated	RT-qPCR	"Circ-SLC8A1 is down-regulated in CKD patient serum. The study reports its altered expression together with mTOR/autophagy marker changes and correlations with renal function indices, supporting potential biomarker relevance in CKD."	0.4128
40521241	Non-coding RNA research	2025	Exosome-derived hsa_circ_0007132 promotes lenvatinib resistance by inhibiting the ubiquitin-mediated degradation of NONO.	hsa_circ_0007132	hsacirc_0007132	hsa_circ_ATXN1	ATXN1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0007132 is upregulated in HCC (including serum exosomes and lenvatinib-resistant settings) and promotes lenvatinib resistance and metastatic traits. It binds the RBP NONO, inhibits NONO ubiquitination/proteasomal degradation, and increases NONO-driven nuclear export of ZEB1 mRNA, elevating ZEB1 protein and EMT. Exosomal transfer of hsa_circ_0007132 can confer resistance phenotypes to recipient HCC cells."	0.8929
40528033	Acta pharmacologica Sinica	2025	Circular RNA circDhx32 promotes cardiac inflammatory responses in mouse cardiac ischemia-reperfusion injury via binding to FOXO1 competed with AdipoR1.	mmu_circ_042424	mmu_circ_42424 / circDhx32	mmu_circ_Dhx32	Dhx32	cardiac ischemia-reperfusion injury / cardiac I/R injury	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR; Microarray	"In mouse cardiac ischemia-reperfusion injury and cardiomyocyte hypoxia/reoxygenation, circDhx32 is upregulated and accumulates in the nucleus. ALKBH5-mediated m6A changes increase circDhx32 stability/nuclear retention, and nuclear circDhx32 binds FOXO1 to repress FOXO1-driven AdipoR1 transcription, thereby aggravating inflammatory responses via the AdipoR1_AMPK_NF-kappaB axis."	0.8196
40529209	Non-coding RNA research	2025	USF1-activated hsa_circ_0076691 induces oxaliplatin resistance via facilitating FGF9 expression in miR-589-3p-dependent manners.	hsa_circ_0076691	circ76691 / circRUNX2	hsa_circ_RUNX2	RUNX2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0076691 (circ76691), derived from RUNX2, is upregulated in oxaliplatin-resistant CRC cells and patient tumors. It promotes oxaliplatin resistance by inhibiting apoptosis via transcriptional repression and sponging of miR-589_3p, thereby increasing FGF9 expression; its expression is activated by the transcription factor USF1 and is associated with poorer patient DFS."	0.8974
40530493	Journal of the American Heart Association	2025	Circ-myh8/KAT7 Affects PANoptosis in Pulmonary Arterial Smooth Muscle Cells: Involvement of Super-Enhancers in FOSL2 Expression.		circ_chr11_67292179_67294612 / circ_myh8	mmu_circ_Myh8	myh8	pulmonary hypertension / PH	MONDO:0005149	pulmonary hypertension	up-regulated	RT-qPCR	"In hypoxia-associated pulmonary hypertension, circ-myh8 is upregulated and promotes PANoptosis in pulmonary arterial smooth muscle cells. Mechanistically, it recruits KAT7 to increase H3K27ac enrichment at the FOSL2 super-enhancer/promoter, elevating FOSL2 expression and downstream PANoptosis markers; circ-myh8 knockdown reduces FOSL2 and alleviates PH phenotypes in mice."	0.414
40533863	Hereditas	2025	circ-NOLC1 inhibits the development of cervical cancer by regulating miR-330-5p-PALM signaling axis.	hsa_circ_0019686	circ-NOLC1	hsa_circ_NOLC1	NOLC1	cervical cancer / CC	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR; Microarray	"circ-NOLC1 (hsa_circ_0019686) is down-regulated in cervical cancer cell lines and acts as a tumor suppressor. It mainly localizes to the cytoplasm and functions as a ceRNA to sponge miR-330-5p, thereby increasing PALM expression and inhibiting proliferation/migration/invasion while promoting apoptosis, including suppression of xenograft tumor growth."	0.7893
40535798	Journal of Cancer	2025	circSLC39A8 by sponging hsa-miR-11181-5p and direct binding to PIK3CA mRNA promotes retinoblastoma proliferation.	hsa_circ_0002782	circSLC39A8 / circSLC39A	hsa_circ_SLC39A8	SLC39A8	Retinoblastoma / RB	MONDO:0008380	retinoblastoma	up-regulated	RT-qPCR; RNA-seq	"circSLC39A8 is up-regulated in retinoblastoma cells and promotes proliferation while inhibiting apoptosis. It sponges hsa-miR-11181-5p to increase PIK3CA mRNA and also directly binds PIK3CA mRNA to enhance its stability, activating PI3K/AKT signaling."	0.75
40537911	Journal of microbiology and biotechnology	2025	EIF4A3-Induced Circ_0092278 Enhances Papillary Thyroid Cancer Cell Malignancy by the PI3K/Akt/mTOR Signaling Pathway.	hsa_circ_0092278	circ_0092278 / hsa_circRNA_400031	hsa_circ_MINK1	MINK1	papillary thyroid cancer / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0092278 is up-regulated in papillary thyroid cancer and predominantly localized in the cytoplasm. It promotes PTC cell proliferation, migration, invasion and xenograft tumor growth by activating the PI3K/AKT/mTOR pathway, and is positively regulated by the RBP EIF4A3 via binding to the host transcript MINK1."	0.753
40539039	Frontiers in immunology	2025	Identification of the microglia-associated signature in experimental autoimmune encephalomyelitis.	mmu_circ_0001569	circGAS2	mmu_circ_GAS2	GAS2	Multiple sclerosis / MS	MONDO:0005301	multiple sclerosis	up-regulated	RT-qPCR; RNA-seq	"mmu-circ-0001569 (circGAS2) is upregulated in microglia from EAE mice and is suggested to have a regulatory role in microglial function. The study frames circRNA involvement mainly through ceRNA network regulation, but does not report specific miRNA/mRNA targets for this circRNA."	0.4997
40542386	Cancer cell international	2025	Hsa_circ_0059511 promote glioma cell proliferation and migration through hsa-miR-194-5p/HBEGF axis.	hsa_circ_0059511	circRNA-0059511			glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"hsa_circ_0059511 is up-regulated in glioma tissues and cell lines and mainly localizes to the cytoplasm. It promotes glioma cell proliferation, migration and invasion, at least partly by sponging hsa-miR-194-5p to increase HBEGF expression, and its knockdown suppresses xenograft tumor growth."	0.8443
40549145	Annals of hematology	2025	Down-regulation of circMUC16 inhibited the progression of ALL via interaction with miR-1182 and TPPP3.	hsa_circ_0049116	circMUC16	hsa_circ_MUC16	MUC16	acute lymphoblastic leukemia / ALL	MONDO:0004967	acute lymphoblastic leukemia	up-regulated	RT-qPCR	"circMUC16 is up-regulated in ALL cell lines and promotes malignant phenotypes by enhancing autophagy and proliferation while inhibiting apoptosis. Mechanistically, it functions as a ceRNA that sponges miR-1182 to increase TPPP3 expression, and circMUC16 knockdown suppresses tumor growth in a Jurkat xenograft model."	0.853
40563085	Renal failure	2025	Identification of core noncoding RNA-associated competing endogenous RNA networks in renal fibrosis via whole-transcriptome sequencing.		circRNA_3140			renal fibrosis / RF	MONDO:0000494	renal fibrosis	up-regulated	RT-qPCR; RNA-seq	"circRNA_3140 is up-regulated in rat renal fibrosis models and acts in the cytoplasm as a ceRNA that competitively binds miR-466b-3p to influence Adamts2 expression, forming a core circRNA_3140/miR-466b-3p/Adamts2 regulatory axis potentially involved in fibrotic progression."	0.7364
40563332	"Antioxidants (Basel, Switzerland)"	2025	CircRNA_1156 Attenuates Neodymium Nitrate-Induced Hepatocyte Ferroptosis by Inhibiting the ACSL4/PKCbetaII Signaling Pathway.		circRNA_1156			Nd(NO3)3-induced hepatocyte ferroptosis	MONDO:0002184	drug-induced hepatitis	down-regulated	RT-qPCR; ISH	"In mouse hepatocytes and a chronic Nd(NO3)3 exposure mouse model, circRNA_1156 is down-regulated after Nd(NO3)3 treatment. circRNA_1156 overexpression protects against Nd(NO3)3-induced hepatocyte ferroptosis by suppressing the ACSL4/PKCbetaII signaling axis, reducing oxidative stress and lipid peroxidation."	0.5089
40568595	Frontiers in immunology	2025	Utilization of artificial circular RNAs as miRNA sponges and anti-PD-1 scFv expression platforms to suppress hepatocellular carcinoma progression.		circSC25-alphaPD1			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	unknown	RT-qPCR	"This engineered artificial circRNA (circSC25-alphaPD1) functions as a miR-25 sponge and simultaneously expresses anti-PD-1 scFv. It suppresses HCC malignant phenotypes (proliferation, invasion/migration, EMT, angiogenesis) and enhances antitumor immunity, leading to inhibited tumor growth and prolonged survival in mouse models."	0.7554
40568595	Frontiers in immunology	2025	Utilization of artificial circular RNAs as miRNA sponges and anti-PD-1 scFv expression platforms to suppress hepatocellular carcinoma progression.		circSC25			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	unknown	RT-qPCR	"circSC25 is an artificial circRNA designed to sponge/silence miR-25. In HCC models, it inhibits malignant behaviors including proliferation, invasion/migration, EMT, and angiogenesis, and suppresses tumor progression in vivo."	0.5442
40568595	Frontiers in immunology	2025	Utilization of artificial circular RNAs as miRNA sponges and anti-PD-1 scFv expression platforms to suppress hepatocellular carcinoma progression.		circ-alphaPD1			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	unknown	Others	"circ-alphaPD1 is an artificial circRNA engineered to express anti-PD-1 scFv. It produces functional scFv that binds PD1, reduces PD-1 signaling in tumors, and promotes antitumor immune responses, contributing to tumor suppression in mouse HCC models."	0.4838
40575981	Animal bioscience	2025	Analysis of circular RNA (circRNA) characteristics and identification of key circRNAs in the hypothalamus during sexual maturation in female goats.		novel_circ_0002274			precocious puberty / sexual maturation	MONDO:0000088	precocious puberty	dysregulated	RT-qPCR; RNA-seq	"novel_circ_0002274 is highlighted as a key circRNA in the goat hypothalamus during postnatal sexual maturation. It is predicted to function via a ceRNA mechanism by sponging chi-miR-197-5p and chi-miR-30c-3p to regulate ESR1, OXT and CACNG3, linking to estrogen and oxytocin signaling and hormone secretion."	0.4566
40576192	"International journal of surgery (London, England)"	2025	Regulation of macrophage plasticity by circCCDC7 19-13 through HSP90 inhibition suppresses prostate cancer progression and metastasis: a translational study.		circCCDC719-13 / circCCDC7 19-13	hsa_circ_CCDC7	CCDC7	prostate cancer / PCa	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; RNA-seq	"circCCDC719-13 is downregulated in prostate cancer-associated TAMs/M2 macrophages. Its overexpression drives ferroptosis and repolarizes TAMs toward an M1-like state by binding to HSP90 and promoting its ubiquitination/degradation, thereby reducing EMT-associated invasion/migration and suppressing tumor growth and metastasis in vivo."	0.7861
40583153	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2025	Single-Droplet Dual-Target Quantification of circRNA Biomarkers for Colorectal Cancer Screening.		circCK1gamma3	hsa_circ_CK1gamma3	CK1gamma3	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"circCK1gamma3 is down-regulated in CRC tissues and in plasma (including early-stage CRC), and its low expression is associated with worse overall survival. Together with circWDR37, it serves as a combined plasma biomarker panel that improves CRC screening performance."	0.6759
40583153	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2025	Single-Droplet Dual-Target Quantification of circRNA Biomarkers for Colorectal Cancer Screening.		circWDR37	hsa_circ_WDR37	WDR37	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circWDR37 is up-regulated in CRC tissue and elevated in CRC patient plasma. High circWDR37 is associated with poor prognosis, and combining circWDR37 with circCK1gamma3 improves CRC screening performance."	0.4992
40583858	CNS neuroscience & therapeutics	2025	CircMAN1A2 Levels Determine GBM Susceptibility to TMZ in a Pathway Involving TEP1- and KEAP1-Mediated NRF2 Degradation Leading to Ferroptosis.	hsa_circ_0000118	circMAN1A2	hsa_circ_MAN1A2	MAN1A2	glioblastoma / GBM	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR; RNA-seq	"circMAN1A2 (hsa_circ_0000118) is down-regulated in glioma/GBM and low expression is associated with higher WHO grade and poorer survival. Functionally, circMAN1A2 suppresses GSC malignant phenotypes and increases TMZ sensitivity by inducing ferroptosis. Mechanistically, it binds TEP1 to promote KEAP1-mediated NRF2 degradation, reducing NRF2/ANXA1 signaling linked to TAM recruitment and M2 polarization."	0.8949
40584151	Gastroenterology report	2025	circNRIP1 impairs tumorigenesis of colorectal cancer by sponging IGF2BP1 and decreasing NACC1 mRNA stability.	hsa_circ_0004771	circNRIP1	hsa_circ_NRIP1	NRIP1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	dysregulated	RT-qPCR; RNA-seq; Microarray	"In colorectal cancer, circNRIP1 is downregulated in tumor tissues but elevated in blood exosomes and can serve as an early diagnostic biomarker. Functionally, circNRIP1 suppresses CRC proliferation/stemness and xenograft tumor growth by binding IGF2BP1 (KH1/2), inhibiting its m6A reader activity and reducing NACC1 mRNA stability; circNRIP1 export may involve the hnRNPK_exosome pathway."	0.8898
40584619	Frontiers in pharmacology	2025	Hsa_circ_0002238 promotes the malignant behavior of colorectal cancer.	hsa_circ_0002238				colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"hsa_circ_0002238 is up-regulated in colorectal cancer tissues and cell lines, localizes mainly in the cytoplasm, and promotes malignant phenotypes (proliferation, migration, invasion, EMT) while inhibiting apoptosis. It is associated with increased PI3K/AKT pathway activation and shows potential diagnostic value (ROC AUC 0.765) in a small clinical cohort."	0.6921
40585335	PeerJ	2025	CircVAMP3 promotes acute lung injury progression by regulating the miR-580-3p/STING/IFN-beta axis in macrophages.	hsa_circ_0006354	circVAMP3 / circRNA.1_7777160_7778169	hsa_circ_VAMP3	VAMP3	acute lung injury / ALI	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR	"circVAMP3 is up-regulated in an LPS-induced THP-1-derived macrophage ALI model and promotes inflammatory signaling by suppressing miR-580-3p, which increases STING and enhances IFN-beta production. The study proposes the circVAMP3/miR-580-3p/STING/IFN-beta axis as a potential therapeutic/biomarker target for ALI/ARDS."	0.5202
40588761	Virology journal	2025	Reference-guided detection of the transcriptome reveals circular RNA-related competing endogenous RNA networks in response to three respiration pathogens in pig lungs.			ssc_circ_TTC3	TTC3	porcine reproductive and respiratory syndrome / PRRS	MONDO:0025494	porcine reproductive and respiratory syndrome	down-regulated	RNA-seq	"In PRRSV-infected pig lungs, the circRNA 13:200,707,866|200,731,785 (from host gene TTC3) is implicated in an RNA-splicing-related ceRNA network. It forms a predicted axis with miR-7-5p and SRSF12 and is among circRNAs showing decreased circular ratio during PRRSV infection."	0.1768
40588761	Virology journal	2025	Reference-guided detection of the transcriptome reveals circular RNA-related competing endogenous RNA networks in response to three respiration pathogens in pig lungs.			ssc_circ_TMEM135	TMEM135	porcine reproductive and respiratory syndrome / PRRS	MONDO:0025494	porcine reproductive and respiratory syndrome	down-regulated	RNA-seq	"The circRNA 9:20,809,498|20,833,620 (host gene TMEM135) is identified as a circRNA whose circular ratio decreases in PRRSV-infected pig lungs, suggesting involvement in PRRSV-associated circRNA splicing imbalance."	0.1768
40588761	Virology journal	2025	Reference-guided detection of the transcriptome reveals circular RNA-related competing endogenous RNA networks in response to three respiration pathogens in pig lungs.			ssc_circ_OBI1	OBI1	porcine reproductive and respiratory syndrome / PRRS	MONDO:0025494	porcine reproductive and respiratory syndrome	down-regulated	RNA-seq	"The circRNA 11:50,762,620|50,773,425 (host gene OBI1) is among circRNAs whose circular ratio decreases in PRRSV-infected pig lungs, consistent with PRRSV-associated disruption of circRNA splicing balance."	0.1768
40588761	Virology journal	2025	Reference-guided detection of the transcriptome reveals circular RNA-related competing endogenous RNA networks in response to three respiration pathogens in pig lungs.			ssc_circ_UNC13B	UNC13B	porcine reproductive and respiratory syndrome / PRRS	MONDO:0025494	porcine reproductive and respiratory syndrome	down-regulated	RNA-seq	"The circRNA 1:235,969,399|235,983,215 (host gene UNC13B) is reported to have decreased circular ratio in PRRSV-infected pig lungs, indicating dysregulation of circRNA biogenesis/splicing under PRRSV challenge."	0.1768
40590107	Journal of periodontal research	2025	Association Between Salivary Circular RNAs Expression and Periodontal Disease Status.	hsa_circ_0003563	circRUNX2	hsa_circ_RUNX2	RUNX2	periodontitis	MONDO:0005076	periodontitis	up-regulated	RT-qPCR	"hsa_circ_0003563 (circRUNX2) is up-regulated in saliva of periodontitis patients and shows strong diagnostic performance for distinguishing periodontitis from non-periodontitis. Bioinformatic analyses predict a circRNA_miRNA_mRNA network (including miR-23-5p) and potential interaction with the RBP EIF4A3, suggesting roles in immune response and inflammation."	0.559
40590107	Journal of periodontal research	2025	Association Between Salivary Circular RNAs Expression and Periodontal Disease Status.	hsa_circ_0064947				periodontitis	MONDO:0005076	periodontitis	up-regulated	RT-qPCR	hsa_circ_0064947 is up-regulated in saliva from periodontitis patients and shows moderate diagnostic performance (AUC 0.76) for distinguishing periodontitis from healthy controls.	0.5261
40590107	Journal of periodontal research	2025	Association Between Salivary Circular RNAs Expression and Periodontal Disease Status.	hsa_circ_0107474				periodontitis	MONDO:0005076	periodontitis	up-regulated	RT-qPCR	hsa_circ_0107474 is up-regulated in saliva from periodontitis patients and provides modest diagnostic value for periodontitis versus healthy controls (AUC 0.70).	0.5261
40590107	Journal of periodontal research	2025	Association Between Salivary Circular RNAs Expression and Periodontal Disease Status.	hsa_circ_0001162				periodontitis	MONDO:0005076	periodontitis	up-regulated	RT-qPCR	hsa_circ_0001162 is up-regulated in saliva from periodontitis patients and shows diagnostic potential for periodontitis versus healthy controls (AUC 0.71).	0.5261
40590107	Journal of periodontal research	2025	Association Between Salivary Circular RNAs Expression and Periodontal Disease Status.	hsa_circ_0137250				periodontitis	MONDO:0005076	periodontitis	up-regulated	RT-qPCR	hsa_circ_0137250 is up-regulated in saliva from periodontitis patients and demonstrates good diagnostic potential for periodontitis versus healthy controls (AUC 0.83).	0.5261
40590107	Journal of periodontal research	2025	Association Between Salivary Circular RNAs Expression and Periodontal Disease Status.	hsa_circ_0001161	circMMP9	hsa_circ_MMP9	MMP9	periodontitis	MONDO:0005076	periodontitis	unknown	RT-qPCR	hsa_circ_0001161 (circMMP9) differs between Grade B and Grade C periodontitis and may serve as a salivary stratification biomarker (AUC 0.82). Bioinformatic predictions suggest it may act through a ceRNA mechanism involving miR-665 to influence immune response and inflammation-related pathways.	0.559
40591172	Discover oncology	2025	Tumor-associated macrophages derived exosomal circPLK1 promotes resistance to EGFR inhibitor osimertinib in non-small cell lung cancer.	hsa_circ_0038632	circPLK1 / Circ0038632	hsa_circ_PLK1	PLK1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"TAM (M2-polarized macrophage)-derived exosomal circPLK1 is transferred into NSCLC cells and promotes resistance to osimertinib. Mechanistically, circPLK1 binds/sponges miR-186 (Ago2-dependent), leading to increased EGFR/AKT/ERK phosphorylation and activation of PI3K/AKT signaling, thereby suppressing apoptosis under OSI treatment."	0.7586
40591591	Proceedings of the National Academy of Sciences of the United States of America	2025	A circular RNA overcomes acquired resistance to BET inhibitors by antagonizing IGF2BP2-mediated c-MYC translation in TNBC.	hsa_circ_0001573	circRNA-BISC / BISC	hsa_circ_RREB1	RREB1	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	down-regulated	RT-qPCR	"BISC (hsa_circ_0001573), derived from RREB1, is down-regulated in BETi-resistant TNBC cells. It directly binds the RBP IGF2BP2 (via ¡°CAC-|9-12|-XGGX¡± motifs) and antagonizes IGF2BP2 recruitment to c-myc mRNA, suppressing c-MYC translation and restoring sensitivity to BET inhibitors; in vivo delivery of circularized BISC plus OTX015 causes tumor regression in resistant xenografts."	0.8118
40593477	Cell death discovery	2025	Circular RNA circLIMK1-005 promotes the progression of lung adenocarcinoma by interacting with RPA1 protein to activate CDK4 signaling.	hsa_circ_0002690	circLIMK1-005 / circLIMK1	hsa_circ_LIMK1	LIMK1	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; ISH	"circLIMK1-005 is up-regulated in LUAD tissues/cells, mainly localized in the nucleus, and its high expression associates with poor patient survival. It promotes LUAD proliferation, cell-cycle progression, migration/invasion, and tumor growth by binding RPA1, increasing RPA1 protein level, and activating Cyclin D1/CDK4 signaling (with AKT phosphorylation as a downstream readout)."	0.8766
40594478	Scientific reports	2025	"Mining, validating, and quantifying circular RNA transcriptome from total RNA as a biomarker or target."		"circASPH(2,4)"	hsa_circ_ASPH	ASPH	sepsis	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR; RNA-seq	"circASPH(2,4) is significantly up-regulated in septic patient PBMCs at ICU admission versus ICU discharge. The study predicts it may interact with specific miRNAs and RBPs (e.g., TLR2, CPEB4, ZC3H12D), suggesting potential ceRNA/RBP-related roles, but these interactions are bioinformatically inferred rather than experimentally validated."	0.6193
40594478	Scientific reports	2025	"Mining, validating, and quantifying circular RNA transcriptome from total RNA as a biomarker or target."		"circASPH(2,3,4)"	hsa_circ_ASPH	ASPH	sepsis	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR	"circASPH(2,3,4) is significantly up-regulated in septic patient PBMCs at ICU admission versus ICU discharge, and its level at ICU admission positively correlates with ICU length of stay, suggesting potential utility as a severity indicator. Predicted interactions include binding to specific miRNAs and RBPs (TLR2/CPEB4/ZC3H12D), but these are based on in silico analyses."	0.6548
40594478	Scientific reports	2025	"Mining, validating, and quantifying circular RNA transcriptome from total RNA as a biomarker or target."		"circTUT4(2,3)"	hsa_circ_TUT4	TUT4	sepsis	MONDO:0005229	bacterial infectious disease with sepsis	down-regulated	RNA-seq	"circTUT4(2,3) is identified from total RNA-seq as differentially expressed, showing lower expression at ICU admission than ICU discharge in septic patient PBMCs. No mechanism or functional validation is provided in the paper for this circRNA."	0.1155
40594478	Scientific reports	2025	"Mining, validating, and quantifying circular RNA transcriptome from total RNA as a biomarker or target."		"circVAPB(4,5)"	hsa_circ_VAPB	VAPB	sepsis	MONDO:0005229	bacterial infectious disease with sepsis	down-regulated	RNA-seq	"circVAPB(4,5) is identified from total RNA-seq as differentially expressed, with reduced expression at ICU admission compared with ICU discharge in septic patient PBMCs. The paper does not provide functional or mechanistic validation for circVAPB(4,5)."	0.1155
40595410	Communications biology	2025	circGIGYF1 inhibits stemness and metastasis in colorectal cancer by promoting WWP2-HOXD13 interaction to regulate beta-catenin signalling.	hsa_circ_0006271	circGIGYF1	hsa_circ_GIGYF1	GIGYF1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Northern Blot	"In colorectal cancer, circGIGYF1 is down-regulated and its low expression is associated with worse overall survival. Functionally, circGIGYF1 suppresses stemness, EMT, and metastasis. Mechanistically, it acts as a scaffold that enhances WWP2-HOXD13 interaction to promote HOXD13 ubiquitination/degradation, reducing HOXD13-driven CTNNB1 transcription and inhibiting Wnt/beta-catenin signaling."	0.8988
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	hsa_circ_0098181	circSOX5	hsa_circ_SOX5	SOX5	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR; RNA-seq	"circSOX5 was profiled as part of a panel of circRNAs tested in ALS-relevant tissues, showing an overall decrease in the ALS CNS (spinal cord) in the SOD1G93A model, with tissue-dependent regulation across CNS versus skeletal muscle."	0.5129
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	mmu_circ_0013172	circSOX5	mmu_circ_SOX5	SOX5	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR; RNA-seq	"circSOX5 was profiled as part of a panel of circRNAs tested in ALS-relevant tissues, showing an overall decrease in the ALS CNS (spinal cord) in the SOD1G93A model, with tissue-dependent regulation across CNS versus skeletal muscle."	0.5129
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	hsa_circ_0034880	circTTBK2	hsa_circ_TTBK2	TTBK2	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR; RNA-seq	"circTTBK2 is significantly down-regulated in brain samples from sporadic ALS patients versus controls, and is part of the circRNA panel showing overall CNS decrease in ALS."	0.5129
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	mmu_circ_0001063	circTTBK2	mmu_circ_TTBK2	TTBK2	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR; RNA-seq	"circTTBK2 is significantly down-regulated in brain samples from sporadic ALS patients versus controls, and is part of the circRNA panel showing overall CNS decrease in ALS."	0.5129
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	hsa_circ_0000591	circMGA	hsa_circ_MGA	MGA	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR; RNA-seq	"circMGA is among the circRNAs identified as particularly altered in ALS in this study, contributing to the broader pattern of CNS downregulation and tissue-dependent circRNA deregulation."	0.385
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	mmu_circ_0009233	circMGA	mmu_circ_MGA	MGA	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR; RNA-seq	"circMGA is among the circRNAs identified as particularly altered in ALS in this study, contributing to the broader pattern of CNS downregulation and tissue-dependent circRNA deregulation."	0.385
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	hsa_circ_0027450	circGRIP1	hsa_circ_GRIP1	GRIP1	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR; RNA-seq	circGRIP1 shows progressive down-regulation in spinal cord during ALS progression in SOD1G93A mice (late presymptomatic through terminal stages).	0.385
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	mmu_circ_0000216	circGRIP1	mmu_circ_GRIP1	GRIP1	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR; RNA-seq	circGRIP1 shows progressive down-regulation in spinal cord during ALS progression in SOD1G93A mice (late presymptomatic through terminal stages).	0.385
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	hsa_circ_0001017	circXPO1	hsa_circ_XPO1	XPO1	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	dysregulated	RT-qPCR	"circXPO1 shows tissue-dependent dysregulation in ALS models (decreased in CNS, generally increased in quadriceps) and is significantly deregulated in sALS brain; it is discussed as a potential ALS biomarker."	0.2995
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	mmu_circ_0000246	circXPO1	mmu_circ_XPO1	XPO1	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	dysregulated	RT-qPCR	"circXPO1 shows tissue-dependent dysregulation in ALS models (decreased in CNS, generally increased in quadriceps) and is significantly deregulated in sALS brain; it is discussed as a potential ALS biomarker."	0.2995
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	hsa_circ_0001189	circMORC3	hsa_circ_MORC3	MORC3	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR; RNA-seq	circMORC3 is progressively down-regulated in spinal cord during ALS progression in SOD1G93A mice (late presymptomatic through terminal stages).	0.385
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	mmu_circ_0006475	circMORC3	mmu_circ_MORC3	MORC3	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR; RNA-seq	circMORC3 is progressively down-regulated in spinal cord during ALS progression in SOD1G93A mice (late presymptomatic through terminal stages).	0.385
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	hsa_circ_0000745	circSPECC1	hsa_circ_SPECC1	SPECC1	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	dysregulated	RT-qPCR	"circSPECC1 is strongly down-regulated in spinal cord at terminal-stage ALS in SOD1G93A mice; it was not quantifiable in quadriceps, consistent with CNS-enriched expression in this study."	0.1155
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	mmu_circ_0003196	circSPECC1	mmu_circ_SPECC1	SPECC1	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	dysregulated	RT-qPCR	"circSPECC1 is strongly down-regulated in spinal cord at terminal-stage ALS in SOD1G93A mice; it was not quantifiable in quadriceps, consistent with CNS-enriched expression in this study."	0.1155
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	hsa_circ_0000137	circASH1L	hsa_circ_ASH1L	ASH1L	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	dysregulated	RT-qPCR	circASH1L is progressively up-regulated in quadriceps across ALS progression in SOD1G93A mice and is proposed as a potential biomarker; its levels correlate with host gene ASH1L expression.	0.2586
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	mmu_circ_0010877	circASH1L	mmu_circ_ASH1L	ASH1L	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	dysregulated	RT-qPCR	circASH1L is progressively up-regulated in quadriceps across ALS progression in SOD1G93A mice and is proposed as a potential biomarker; its levels correlate with host gene ASH1L expression.	0.2586
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	hsa_circ_0000615	circZfp609circZNF609	hsa_circ_ZNF609	Zfp609/ZNF609	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	dysregulated	RT-qPCR	"circZfp609/circZNF609 is among the circRNAs profiled in ALS tissues and shows a significant positive correlation with its host gene expression specifically in spinal cord, consistent with coordinated deregulation in ALS."	0.1155
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	mmu_circ_0001797	circZfp609circZNF609	mmu_circ_Zfp609	Zfp609/ZNF609	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	dysregulated	RT-qPCR	"circZfp609/circZNF609 is among the circRNAs profiled in ALS tissues and shows a significant positive correlation with its host gene expression specifically in spinal cord, consistent with coordinated deregulation in ALS."	0.1155
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	hsa_circ_0000826	circANKRD12	hsa_circ_ANKRD12	ANKRD12	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	dysregulated	RT-qPCR	"circANKRD12 tends to increase in ALS quadriceps (SOD1G93A, later stages) and is discussed as a potential biomarker; its expression correlates with host gene levels in quadriceps."	0.1155
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	mmu_circ_0000807	circANKRD12	mmu_circ_ANKRD12	ANKRD12	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	dysregulated	RT-qPCR	"circANKRD12 tends to increase in ALS quadriceps (SOD1G93A, later stages) and is discussed as a potential biomarker; its expression correlates with host gene levels in quadriceps."	0.1155
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	hsa_circ_0001380	circUBXN7	hsa_circ_UBXN7	UBXN7	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	dysregulated	RT-qPCR	"circUBXN7 is strongly up-regulated in quadriceps at terminal-stage ALS in SOD1G93A mice and shows coordinated expression with its host gene in quadriceps, fitting the tissue-dependent ALS circRNA pattern."	0.1155
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	mmu_circ_0006195	circUBXN7	mmu_circ_UBXN7	UBXN7	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	dysregulated	RT-qPCR	"circUBXN7 is strongly up-regulated in quadriceps at terminal-stage ALS in SOD1G93A mice and shows coordinated expression with its host gene in quadriceps, fitting the tissue-dependent ALS circRNA pattern."	0.1155
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	hsa_circ_0008870	circMAPK1	hsa_circ_MAPK1	MAPK1	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR; RNA-seq	circMAPK1 is progressively down-regulated in spinal cord during ALS progression in SOD1G93A mice and is also significantly down-regulated in sALS brain; its levels correlate with MAPK1 host gene expression in both spinal cord and quadriceps.	0.5129
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	mmu_circ_0006095	circMAPK1	mmu_circ_MAPK1	MAPK1	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR; RNA-seq	circMAPK1 is progressively down-regulated in spinal cord during ALS progression in SOD1G93A mice and is also significantly down-regulated in sALS brain; its levels correlate with MAPK1 host gene expression in both spinal cord and quadriceps.	0.5129
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	hsa_circ_0001439	circSCLT1	hsa_circ_SCLT1	SCLT1	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR	"circSCLT1 is markedly down-regulated in ALS CNS (SOD1G93A spinal cord terminal stage and sALS brain), aligning with the study¡¯s CNS-decrease pattern."	0.2995
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	mmu_circ_0010671	circSCLT1	mmu_circ_SCLT1	SCLT1	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR	"circSCLT1 is markedly down-regulated in ALS CNS (SOD1G93A spinal cord terminal stage and sALS brain), aligning with the study¡¯s CNS-decrease pattern."	0.2995
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	hsa_circ_0001451	circFBXW7	hsa_circ_FBXW7	FBXW7	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR	"circFBXW7 is part of the circRNA set profiled in ALS tissues and is highlighted among the circRNAs particularly altered in ALS in this work, consistent with overall CNS downregulation."	0.1155
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	mmu_circ_0010819 	circFBXW7	mmu_circ_FBXW7	FBXW7	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR	"circFBXW7 is part of the circRNA set profiled in ALS tissues and is highlighted among the circRNAs particularly altered in ALS in this work, consistent with overall CNS downregulation."	0.1155
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	hsa_circ_0004846	circSamd4circSAMD4A	hsa_circ_SAMD4A	SAMD4A	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR	"circSAMD4A is significantly down-regulated in sALS brain; in the mouse model it is part of the circRNA set showing tissue-dependent deregulation, though circSamd4 did not significantly correlate with host gene expression."	0.2995
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	mmu_circ_0000529	circSamd4circSAMD4A	mmu_circ_Samd4	Samd4	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR	"circSAMD4A is significantly down-regulated in sALS brain; in the mouse model it is part of the circRNA set showing tissue-dependent deregulation, though circSamd4 did not significantly correlate with host gene expression."	0.2995
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	hsa_circ_0000994	circSLC8A1	hsa_circ_SLC8A1	SLC8A1	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR	"circSLC8A1 is decreased in ALS quadriceps at symptomatic and terminal stages and follows the same decreasing pattern as in spinal cord, standing out from the generally increased muscle circRNAs."	0.1155
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	mmu_circ_0000823	circSLC8A1	mmu_circ_SLC8A1	SLC8A1	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR	"circSLC8A1 is decreased in ALS quadriceps at symptomatic and terminal stages and follows the same decreasing pattern as in spinal cord, standing out from the generally increased muscle circRNAs."	0.1155
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	hsa_circ_0072654	circCWC27	hsa_circ_CWC27	CWC27	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	dysregulated	RT-qPCR	"circCWC27 is progressively decreased in ALS spinal cord from late presymptomatic to terminal stages and shows coordinated expression with its host gene specifically in quadriceps, supporting tissue-dependent deregulation."	0.1155
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	mmu_circ_0004423	circCWC27	mmu_circ_Cwc27	CWC27	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	dysregulated	RT-qPCR	"circCWC27 is progressively decreased in ALS spinal cord from late presymptomatic to terminal stages and shows coordinated expression with its host gene specifically in quadriceps, supporting tissue-dependent deregulation."	0.1155
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	hsa_circ_0000118	circMAN1A2 / mmu_circ_001029	hsa_circ_MAN1A2	MAN1A2	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	dysregulated	RT-qPCR	circMAN1A2 is highly up-regulated in ALS quadriceps at terminal stage and correlates with its host gene in both spinal cord and quadriceps; it is also discussed as a potential biomarker of ALS or muscle damage.	0.1155
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.		circMAN1A2 / mmu_circ_001029	mmu_circ_MAN1A2	MAN1A2	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	dysregulated	RT-qPCR	circMAN1A2 is highly up-regulated in ALS quadriceps at terminal stage and correlates with its host gene in both spinal cord and quadriceps; it is also discussed as a potential biomarker of ALS or muscle damage.	0.1155
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	hsa_circ_0001756	circHIPK2	hsa_circ_HIPK2	HIPK2	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	dysregulated	RT-qPCR	"circHIPK2 increases in ALS quadriceps from P75 to P120 and is discussed as a potential biomarker; unlike many circRNAs, circHIPK2 did not show significant correlation with its host gene expression in the tested tissues."	0.1155
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	mmu_circ_0001468	circHIPK2	mmu_circ_HIPK2	HIPK2	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	dysregulated	RT-qPCR	"circHIPK2 increases in ALS quadriceps from P75 to P120 and is discussed as a potential biomarker; unlike many circRNAs, circHIPK2 did not show significant correlation with its host gene expression in the tested tissues."	0.1155
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	hsa_circ_0000284	circHIPK3	hsa_circ_HIPK3	HIPK3	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR	circHIPK3 is progressively down-regulated in spinal cord during ALS progression (late presymptomatic to terminal) and its expression correlates with HIPK3 host gene levels in spinal cord.	0.1155
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	mmu_circ_0001052	circHIPK3	mmu_circ_HIPK3	HIPK3	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	down-regulated	RT-qPCR	circHIPK3 is progressively down-regulated in spinal cord during ALS progression (late presymptomatic to terminal) and its expression correlates with HIPK3 host gene levels in spinal cord.	0.1155
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	hsa_circ_0001946	ciRS7 / circCDR1as	hsa_circ_CDR1as	CDR1-AS	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	dysregulated	RT-qPCR	ciRS7/circCDR1as decreases progressively in ALS spinal cord from early presymptomatic to terminal stages but increases in ALS quadriceps from P75 to P120; it is discussed as a potential biomarker of ALS or muscle damage.	0.1155
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	mmu_circ_0001878	ciRS7 / circCDR1as	mmu_circ_CDR1-AS	CDR1-AS	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	dysregulated	RT-qPCR	ciRS7/circCDR1as decreases progressively in ALS spinal cord from early presymptomatic to terminal stages but increases in ALS quadriceps from P75 to P120; it is discussed as a potential biomarker of ALS or muscle damage.	0.1155
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	hsa_circ_0003770	circARF3	hsa_circ_ARF3	ARF3	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	dysregulated	RT-qPCR	"circARF3 is part of the ALS circRNA panel and shows a significant positive correlation with ARF3 host gene expression specifically in spinal cord, consistent with coordinated deregulation in ALS tissues."	0.1155
40596818	BMC genomics	2025	Circular RNA expression in ALS is progressively deregulated and tissue-dependent.	mmu_circ_0000650	circARF3	mmu_circ_ARF3	ARF3	amyotrophic lateral sclerosis / ALS	MONDO:0004976	amyotrophic lateral sclerosis	dysregulated	RT-qPCR	"circARF3 is part of the ALS circRNA panel and shows a significant positive correlation with ARF3 host gene expression specifically in spinal cord, consistent with coordinated deregulation in ALS tissues."	0.1155
40596955	BMC nephrology	2025	Diagnostic value of hsa_circ_0012138 in the chronic progression of obstructive nephropathy.	hsa_circ_0012138	hsa_cir_0012138 / circ_001238	hsa_circ_ERI3	ERI3	Obstructive nephropathy	MONDO:0056796	obstructive nephropathy	up-regulated	RT-qPCR	hsa_circ_0012138 is up-regulated in kidneys and urine of obstructive nephropathy patients and localizes mainly to the cytoplasm of tubular epithelial cells. The study proposes that it may regulate renal fibrosis via a predicted ceRNA mechanism (sponging multiple miRNAs to affect upregulated target genes enriched in inflammatory/fibrosis-related programs). Urinary hsa_circ_0012138 has diagnostic/prognostic value for predicting renal function reversibility after kidney-sparing surgery.	0.6556
40597269	Journal of translational medicine	2025	Hsa_circ_0016662 acts as a prognostic biomarker and promotes the progression of hepatocellular carcinoma via autophagy regulation.	hsa_circ_0016662		hsa_circ_ENAH	ENAH	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0016662 is upregulated in HCC tissues and cell lines and functions as an oncogenic circRNA. It promotes HCC proliferation, migration and metastasis by sponging hsa-miR-22-3p to regulate YWHAZ, with autophagy contributing to the malignant phenotype."	0.7738
40597918	BMC cancer	2025	Overexpression of KRAS enhanced the stemness of esophageal cancer cells inhibited by overexpression of circ0043898.		circ0043898			esophageal cancer / EC	MONDO:0007576	esophageal cancer	down-regulated	RT-qPCR	"In esophageal cancer cell lines, circ0043898 overexpression suppresses cancer stemness by decreasing CD44/CD133-positive populations and spheroid formation. circ0043898 downregulates KRAS and reduces PI3K/p-PI3K levels, while KRAS overexpression functionally rescues the stemness inhibition, supporting a circ0043898_KRAS_PI3K/AKT suppressive axis."	0.4636
40604397	BMC molecular and cell biology	2025	"circFTO binding with IGF2BP2 regulates trophoblast cells proliferation, migration, and invasion while mediating m6A modification of CCAR1 mRNA in spontaneous abortion."	hsa_circ_0005941	circFTO	hsa_circ_FTO	FTO	Spontaneous abortion / SA	MONDO:0006774	habitual spontaneous abortion	up-regulated	RT-qPCR; RNA-seq	"circFTO (hsa_circ_0005941) is up-regulated in placental villi from SA patients and suppresses trophoblast proliferation, migration, and invasion. Mechanistically, circFTO binds IGF2BP2 and promotes its ubiquitination/proteasomal degradation, thereby altering IGF2BP2-dependent m6A recognition and the stability/m6A modification of CCAR1 mRNA in trophoblasts."	0.8314
40605033	Molecular cancer	2025	CircERC1 facilitates chemoresistance through inhibiting pyroptosis and remodeling extracellular matrix in pancreatic cancer.	hsa_circ_0000373	circERC1 / circ_0000373	hsa_circ_ERC1	ERC1	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"In PDAC, circERC1 (hsa_circ_0000373) is induced by PTX/GEM-NabP and promotes chemoresistance, proliferation and migration. Mechanistically, it binds hnRNPA1 to block SUMOylation at K183 and enhance ubiquitin-mediated hnRNPA1 degradation, suppressing PKM2/NLRP3/Caspase-1/GSDMD pyroptosis; EV-delivered circERC1 also sponges miR-129-5p to increase COL1A1 in CAFs, promoting ECM deposition and limiting drug/immune infiltration."	0.8968
40611320	Journal of experimental & clinical cancer research : CR	2025	Extracellular vesicle-mediated transmission of circPDLIM5 promotes lymphatic metastasis in prostate cancer.	hsa_circ_0004028	circPDLIM5	hsa_circ_PDLIM5	PDLIM5	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circPDLIM5 (hsa_circ_0004028), derived from PDLIM5, is upregulated in LN-positive prostate cancer tissues and in urinary/serum EVs. It is packaged into EVs via hnRNPA2B1 and delivered to HLECs, where it binds YY1 and promotes PROX1 transcription, enhancing lymphangiogenesis and lymph node metastasis in a VEGF-C-independent manner; high EV circPDLIM5 levels indicate LN metastasis and poor PFS."	0.8981
40612865	Oncology research	2025	circACTN4 promotes breast cancer cell cycle progression and oncogenesis via c-MYC induced histone H4 acetylation.		circACTN4 / circular RNA ACTN4	hsa_circ_ACTN4	ACTN4	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; ISH; Microarray	"circACTN4 is up-regulated in breast cancer and mainly localizes to the nucleus. It promotes proliferation, migration/invasion and xenograft tumor growth by increasing MYC expression, enhancing TIP60-dependent histone H4 acetylation at MYC target genes (e.g., CCNE1 and CDK4), thereby driving G1/S cell cycle progression; high circACTN4 is associated with poorer overall survival."	0.8595
40617805	Cell death & disease	2025	Circ0515 reprogramming mitochondrial succinate metabolism and promotes lung adenocarcinoma progression through regulating SDHB.	hsa_circ_0000515	circ_0000515 / circ0515	hsa_circ_RPPH1	RPPH1	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; Microarray	"circ0515 is up-regulated in lung cancer/LUAD and promotes proliferation, migration/invasion and xenograft growth. Mechanistically it sponges miR-328-3p to de-repress YWHAZ and activate PI3K/AKT signaling, and it binds RBM45 to stabilize SDHB mRNA, enhancing mitochondrial oxidative phosphorylation/succinate metabolism and cisplatin resistance."	0.8901
40620646	Central-European journal of immunology	2025	Hsa_circ_0001445 regulates acne inflammation via sponging miR-1298-5p targeting ESR1.	hsa_circ_0001445				acne	MONDO:0011438	acne	down-regulated	RT-qPCR; Microarray	"In acne, hsa_circ_0001445 is down-regulated in patient biopsy microarray data and in Bio-C. acnes-stimulated keratinocytes/sebocytes. Its overexpression suppresses inflammatory cytokine secretion by sponging miR-1298-5p and relieving repression of ESR1 (hsa_circ_0001445/miR-1298-5p/ESR1 axis)."	0.6432
40626007	Frontiers in oncology	2025	Hsa_circ_0018909 promotes non-small cell lung cancer by directly regulating hsa-miR-513b-5p.	hsa_circ_0018909	circ_0018909	hsa_circ_VDAC2	VDAC2	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0018909 is upregulated in NSCLC tissues and cell lines and promotes proliferation, migration, invasion, and xenograft tumor growth. It functions mainly in the cytoplasm as a ceRNA that sponges hsa-miR-513b-5p, leading to increased MDH1 expression and poorer patient survival when highly expressed."	0.8152
40628993	Scientific reports	2025	Circ_0008043 promotes the metastasis of hepatocellular carcinoma by regulating the miR-661/PLEKHG4B axis.	hsa_circ_0008043	circ_0008043 / circPTGR1	hsa_circ_PTGR1	PTGR1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0008043 (circPTGR1), derived from PTGR1 exons 5_9, is up-regulated in HCC tissues and cell lines and mainly localizes to the cytoplasm. It promotes HCC cell viability, migration/EMT and lung metastasis by acting as a ceRNA sponge for miR-661, thereby relieving miR-661-mediated repression of PLEKHG4B; ESRP1 enhances circ_0008043 biogenesis."	0.8584
40629030	Iranian biomedical journal	2025	"Upregulation of CircCSPP1, CircNRIP1, and CircSMAD2 in Breast Cancer and Their Potential as Diagnostic Biomarkers."	hsa_circ_0001806	circCSPP1	hsa_circ_CSPP1	CSPP1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circCSPP1 (hsa_circ_0001806) is significantly up-regulated in breast cancer tumor tissues versus adjacent normal tissues, with higher expression in ER-/PR-/HER2- and TNBC subgroups. It shows strong diagnostic performance in BC based on ROC analysis."	0.6238
40629030	Iranian biomedical journal	2025	"Upregulation of CircCSPP1, CircNRIP1, and CircSMAD2 in Breast Cancer and Their Potential as Diagnostic Biomarkers."	hsa_circ_0004771	circNRIP1	hsa_circ_NRIP1	NRIP1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	circNRIP1 (hsa_circ_0004771) is significantly up-regulated in breast cancer tumor tissues and is elevated in ER-negative and TNBC subgroups. It shows the best diagnostic performance among tested circRNAs by ROC analysis.	0.6238
40629030	Iranian biomedical journal	2025	"Upregulation of CircCSPP1, CircNRIP1, and CircSMAD2 in Breast Cancer and Their Potential as Diagnostic Biomarkers."	hsa_circ_0000847	circSMAD2	hsa_circ_SMAD2	SMAD2	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	circSMAD2 (hsa_circ_0000847) is significantly up-regulated in breast cancer tumor tissues versus adjacent normal tissues. It has good diagnostic potential for BC based on ROC analysis.	0.6238
40629330	Molecular cancer	2025	M6A-Methylated circRAPGEF5 drives lung adenocarcinoma progression and metastasis via IGF2BP2/NUP160-mediated autophagy suppression.		circRAPGEF5	hsa_circ_RAPGEF5	RAPGEF5	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"circRAPGEF5 is up-regulated in LUAD and predominantly localizes in the cytoplasm. It binds the m6A reader IGF2BP2 and promotes IGF2BP2-dependent stabilization of NUP160 mRNA, suppressing autophagy and thereby enhancing LUAD proliferation, EMT, invasion, and metastasis, including in xenograft models."	0.8326
40630134	Frontiers in pharmacology	2025	CircASH1L inhibits ferroptosis and enhances cisplatin resistance by sponging miR-515-5p to regulate cell cycle-related CDCA7/RRM2 in ovarian cancer cells.	hsa_circ_0014592	circASH1L	hsa_circ_ASH1L	ASH1L	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; RNA-seq	"In cisplatin-resistant ovarian cancer cells, circASH1L is upregulated and promotes chemoresistance by inhibiting ferroptosis. It sponges miR-515-5p to upregulate CDCA7, which supports RRM2 stability and cell-cycle progression, thereby reducing ferroptotic responses and sustaining drug resistance."	0.8748
40630134	Frontiers in pharmacology	2025	CircASH1L inhibits ferroptosis and enhances cisplatin resistance by sponging miR-515-5p to regulate cell cycle-related CDCA7/RRM2 in ovarian cancer cells.	hsa_circ_0007761	circATXN7	hsa_circ_ATXN7	ATXN7	ovarian cancer / OC	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR; RNA-seq	"circATXN7 was identified by RNA-seq as one of three circRNAs reduced after erastin treatment and its downregulation was confirmed by qRT-PCR in ovarian cancer cells, suggesting a potential association with ferroptosis induction."	0.1904
40630134	Frontiers in pharmacology	2025	CircASH1L inhibits ferroptosis and enhances cisplatin resistance by sponging miR-515-5p to regulate cell cycle-related CDCA7/RRM2 in ovarian cancer cells.	hsa_circ_0000467	circSKA3	hsa_circ_SKA3	SKA3	ovarian cancer / OC	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR; RNA-seq	"circSKA3 was identified by RNA-seq as one of three circRNAs reduced after erastin treatment and its downregulation was confirmed by qRT-PCR in ovarian cancer cells, suggesting a potential association with ferroptosis induction."	0.1904
40630792	Acta histochemica et cytochemica	2025	Impact of circPVT1 Expression on Prostate Cancer Malignancy and Tumor Growth.		circPVT1 / circularPVT1	hsa_circ_PVT1	PVT1	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; ISH	"circPVT1 is more frequently expressed in higher-grade prostate cancer (GG2_5 vs GG1) and localizes to the cytoplasm in tumor cells. Specific knockdown of circPVT1 (CRISPR/RfxCas13d) reduces PC-3 cell numbers, supporting a pro-proliferative role and potential therapeutic target; let-7c is upregulated after knockdown, suggesting a possible circPVT1_miRNA interaction."	0.5297
40634303	Cell death discovery	2025	"Circular RNA profiling identifies circ_0001522, circ_0001278, and circ_0001801 as predictors of unfavorable prognosis and drivers of triple-negative breast cancer hallmarks."	hsa_circ_0001522	circ_0001522	hsa_circ_CSNK1G3	CSNK1G3	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ_0001522 is upregulated in breast cancer/TNBC and high expression is linked to poor relapse-free survival. Its knockdown suppresses TNBC proliferation, colony formation, 3D growth and migration. Mechanistically, it is predicted to function via miRNA sponging (miR-579-3p, miR-4458) and potential RBP interactions, reshaping downstream mRNA programs (e.g., CCND1, MMP1)."	0.8182
40634303	Cell death discovery	2025	"Circular RNA profiling identifies circ_0001522, circ_0001278, and circ_0001801 as predictors of unfavorable prognosis and drivers of triple-negative breast cancer hallmarks."	hsa_circ_0001278	circ_0001278			triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ_0001278 is upregulated in breast cancer/TNBC and its high expression associates with poor RFS. Silencing circ_0001278 reduces TNBC proliferative and migratory phenotypes and suppresses 3D growth. Mechanistically, it is predicted to sponge let-7c-5p, miR-145-5p, and miR-4458 and to participate in broader post-transcriptional regulation, including predicted RBP interactions."	0.8182
40634303	Cell death discovery	2025	"Circular RNA profiling identifies circ_0001522, circ_0001278, and circ_0001801 as predictors of unfavorable prognosis and drivers of triple-negative breast cancer hallmarks."	hsa_circ_0001801	circ_0001801 / circPCMTD1	hsa_circ_PCMTD1	PCMTD1	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ_0001801 is upregulated in breast cancer/TNBC and elevated expression is associated with poor RFS. Knockdown reduces TNBC proliferative capacity, 3D growth, and migration. It is predicted to regulate gene expression via ceRNA activity (miR-29b-2-5p/miR-760/miR-7977) and via predicted interactions with RBPs involved in post-transcriptional control."	0.8182
40634861	BMC psychiatry	2025	CircRNA-miRNA-mRNA networks in plasma extracellular vesicles as biomarkers for first-onset schizophrenia.	hsa_circ_0036984		hsa_circ_CDH2	CDH2	first-onset schizophrenia / FOS	MONDO:0005090	schizophrenia	up-regulated	RT-qPCR; RNA-seq	"This EV-associated circRNA (hsa_circ_0036984; chr15:93496587_93499879+) is up-regulated in plasma extracellular vesicles from first-onset schizophrenia patients and is part of a circRNA_miRNA_mRNA network with hsa-miR-20b-5p and ANKH. The circRNA and its network show diagnostic potential (ROC analysis) and the circRNA level correlates with PANSS scores, while the functional mechanism is not experimentally validated beyond network inference."	0.5047
40634861	BMC psychiatry	2025	CircRNA-miRNA-mRNA networks in plasma extracellular vesicles as biomarkers for first-onset schizophrenia.	hsa_circ_0005485		hsa_circ_CDK13	CDK13	first-onset schizophrenia / FOS	MONDO:0005090	schizophrenia	down-regulated	RT-qPCR; RNA-seq	"This EV-associated circRNA (hsa_circ_0005485; chr7:40037093_40087476+) is down-regulated in plasma extracellular vesicles from first-onset schizophrenia patients and forms a circRNA_miRNA_mRNA network with hsa-miR-22-3p and C5orf24. It shows diagnostic value by ROC analysis and its level correlates positively with PANSS scores, while direct mechanistic validation of binding/regulation is not provided."	0.5047
40634861	BMC psychiatry	2025	CircRNA-miRNA-mRNA networks in plasma extracellular vesicles as biomarkers for first-onset schizophrenia.	hsa_circ_0050042		hsa_circ_FCHO1	FCHO1	first-onset schizophrenia / FOS	MONDO:0005090	schizophrenia	down-regulated	RT-qPCR; RNA-seq	"This EV-associated circRNA (hsa_circ_0050042; chr19:17883266_17883550+) is down-regulated in plasma extracellular vesicles from first-onset schizophrenia patients and participates in a circRNA_miRNA_mRNA network with hsa-miR-502-3p and B4GALT5. It has diagnostic potential by ROC analysis and its level correlates with PANSS scores, but direct binding/regulatory validation is not performed in this study."	0.5047
40640166	Nature communications	2025	Regulation of partial endothelial-to-mesenchymal transition by circATXN1 in ischemic diseases.		circATXN1 / circ-ATXN1	hsa_circ_ATXN1	ATXN1	ischemic disease	MONDO:0005294	peripheral vascular disease	up-regulated	RT-qPCR; RNA-seq	"circATXN1 is up-regulated in endothelial cells under ischemic/hypoxic conditions and in ischemic tissues, and is also elevated in peripheral blood exosomes of MI and lower limb ischemia patients. Functionally, circATXN1 restrains hypoxia-induced partial EndMT and angiogenesis, whereas circATXN1 knockdown promotes partial EndMT and improves post-ischemic vascular and cardiac recovery. Mechanistically, circATXN1 binds ALKBH5 to regulate its nuclear-cytoplasmic trafficking and m6A-dependent pre-SLUG mRNA stability, thereby controlling SLUG levels."	0.8987
40640166	Nature communications	2025	Regulation of partial endothelial-to-mesenchymal transition by circATXN1 in ischemic diseases.		circATXN1 / circ-ATXN1	mmu_circ_ATXN1	ATXN1	ischemic disease	MONDO:0005294	peripheral vascular disease	up-regulated	RT-qPCR; RNA-seq	"circATXN1 is up-regulated in endothelial cells under ischemic/hypoxic conditions and in ischemic tissues, and is also elevated in peripheral blood exosomes of MI and lower limb ischemia patients. Functionally, circATXN1 restrains hypoxia-induced partial EndMT and angiogenesis, whereas circATXN1 knockdown promotes partial EndMT and improves post-ischemic vascular and cardiac recovery. Mechanistically, circATXN1 binds ALKBH5 to regulate its nuclear-cytoplasmic trafficking and m6A-dependent pre-SLUG mRNA stability, thereby controlling SLUG levels."	0.8987
40640337	Oncogene	2025	The molecular axis hnRNPU/circKCNK2/EDC4/IL-11 aggravates osteolytic bone metastasis of RCC.	hsa_circ_0016459	circKCNK2	hsa_circ_KCNK2	KCNK2	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR; Northern Blot; ISH; Microarray	"circKCNK2 (hsa_circ_0016459) is up-regulated in RCC bone metastases and promotes RCC aggressiveness and osteolytic bone metastasis. Mechanistically, it binds EDC4alpha-helical to destabilize the EDC4/DCP1/DCP2 P-body complex, stabilizing IL-11 mRNA and activating IL-11/STAT-3 signaling to enhance osteoclast differentiation; acidic microenvironment-driven hnRNPU downregulation increases circKCNK2 biogenesis."	0.8983
40640792	BMC medical genomics	2025	Integrated analysis reveals key circRNA-mediated regulatory axes related to prognosis and immune infiltration in lung adenocarcinoma.	hsa_circ_0072088		hsa_circ_ZFR	ZFR	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"In LUAD, hsa_circ_0072088 is up-regulated and forms a ceRNA axis with hsa-miR-532-3p to modulate MMP14. This axis is proposed to contribute to carcinogenesis and relate to prognosis and immune infiltration, and was supported by qPCR and dual-luciferase assays plus perturbation experiments."	0.4851
40640792	BMC medical genomics	2025	Integrated analysis reveals key circRNA-mediated regulatory axes related to prognosis and immune infiltration in lung adenocarcinoma.	hsa_circ_0049271		hsa_circ_KEAP1	KEAP1	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; Microarray	"In LUAD, hsa_circ_0049271 is down-regulated and participates in a ceRNA axis where it binds hsa-miR-224-5p to influence DCN expression. The axis is suggested to impact tumor initiation, prognosis and immune modulation, supported by qPCR, luciferase assays, and circRNA overexpression with rescue by miRNA mimic."	0.4851
40640792	BMC medical genomics	2025	Integrated analysis reveals key circRNA-mediated regulatory axes related to prognosis and immune infiltration in lung adenocarcinoma.	hsa_circ_0000519		hsa_circ_RPPH1	RPPH1	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	Microarray	hsa_circ_0000519 was identified as an up-regulated differentially expressed circRNA in LUAD microarray datasets and was included in the constructed ceRNA network as a predicted binder of hsa-miR-328-3p. No experimental validation or downstream functional mechanism was reported for this circRNA in this study.	0.1768
40649761	International journal of molecular sciences	2025	The Involvement of LvSRSF2 in Circular RNA Biogenesis and Its Role in Immunity Against White Spot Syndrome Virus (WSSV) in Litopenaeus vannamei.		circ-Alpha2		Alpha2	white spot syndrome virus (WSSV) infection	MONDO:0005108	viral infectious disease	up-regulated	RT-qPCR	"circ-Alpha2 is an LvSRSF2-regulated circRNA whose expression increases in hemocytes during WSSV infection and is strongly affected by LvSRSF2 knockdown, suggesting it is part of the shrimp circRNA response to viral challenge."	0.3513
40649761	International journal of molecular sciences	2025	The Involvement of LvSRSF2 in Circular RNA Biogenesis and Its Role in Immunity Against White Spot Syndrome Virus (WSSV) in Litopenaeus vannamei.		circ-Anillin		Anillin	white spot syndrome virus (WSSV) infection	MONDO:0005108	viral infectious disease	up-regulated	RT-qPCR	"circ-Anillin is upregulated in hemocytes upon WSSV infection and is sensitive to LvSRSF2 knockdown, indicating it is part of the LvSRSF2-associated circRNA biogenesis response during viral infection."	0.3513
40649761	International journal of molecular sciences	2025	The Involvement of LvSRSF2 in Circular RNA Biogenesis and Its Role in Immunity Against White Spot Syndrome Virus (WSSV) in Litopenaeus vannamei.		circ-Hemocytin / circHemocytin		Hemocytin	white spot syndrome virus (WSSV) infection	MONDO:0005108	viral infectious disease	up-regulated	RT-qPCR	"circ-Hemocytin is upregulated in shrimp during WSSV infection, is predicted to sponge multiple WSSV-responsive miRNAs, and is linked to immune-related target genes (e.g., STAT, Vago4). siRNA targeting its back-splice junction decreases circ-Hemocytin levels without affecting linear Hemocytin and reduces WSSV load in gills, supporting a role in antiviral defense."	0.5079
40649761	International journal of molecular sciences	2025	The Involvement of LvSRSF2 in Circular RNA Biogenesis and Its Role in Immunity Against White Spot Syndrome Virus (WSSV) in Litopenaeus vannamei.		circ-Nephrin		Nephrin	white spot syndrome virus (WSSV) infection	MONDO:0005108	viral infectious disease	up-regulated	RT-qPCR	"circ-Nephrin is induced in hemocytes during WSSV infection and is also increased upon LvSRSF2 knockdown, supporting its status as an LvSRSF2-associated circRNA responsive to viral challenge."	0.3513
40649761	International journal of molecular sciences	2025	The Involvement of LvSRSF2 in Circular RNA Biogenesis and Its Role in Immunity Against White Spot Syndrome Virus (WSSV) in Litopenaeus vannamei.		circ-Toll		Toll	white spot syndrome virus (WSSV) infection	MONDO:0005108	viral infectious disease	up-regulated	RT-qPCR	"circ-Toll is induced in hemocytes during WSSV infection and its expression increases upon LvSRSF2 knockdown, indicating it is part of the LvSRSF2-regulated circRNA response to WSSV."	0.3513
40653497	Journal of experimental & clinical cancer research : CR	2025	m5C-modified circRREB1 promotes lung cancer progression by inducing mitophagy.		circRREB1	hsa_circ_RREB1	RREB1	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; RNA-seq; Microarray	"circRREB1 is up-regulated in lung cancer and predicts poor prognosis. NSUN2-mediated m5C modification enables ALYREF-dependent nuclear export, and cytoplasmic circRREB1 binds/stabilizes HSPA8 by inhibiting its ubiquitination, activating the HSPA8_PINK1/Parkin axis to induce mitophagy and promote tumor progression."	0.904
40655469	Journal of hepatocellular carcinoma	2025	Hsa_circ_0007991 Promotes Immune Evasion in Hepatocellular Carcinoma via Regulation of the miR-505-3p/CANX Axis.	hsa_circ_0007991		hsa_circ_EIF4G3	EIF4G3	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0007991 is up-regulated in HCC tissues/cell lines and promotes tumor cell proliferation and immune evasion while inhibiting apoptosis. Mechanistically, it mainly localizes to the cytoplasm and functions as a ceRNA that sponges miR-505-3p to increase CANX expression, impacting PD-L1 and TGF-beta/SMAD-related immunosuppressive signaling in co-culture assays with CD8+ T cells."	0.8237
40657383	International journal of medical sciences	2025	CircRNA Sequencing Analysis Reveals the Regulatory Role of circ_CDR1as in Penile Squamous Cell Carcinoma via the ceRNA Network.		circ_CDR1as / ciRS-7	hsa_circ_CDR1	CDR1	Penile squamous cell carcinoma / PSCC	MONDO:0018352	squamous cell carcinoma of penis	down-regulated	RT-qPCR; RNA-seq	"circ_CDR1as is significantly down-regulated in PSCC tissues and is proposed to act via a ceRNA network. The study predicts that circ_CDR1as may sponge miR-944/miR-1270 and thereby modulate downstream targets, with GATA6 showing consistent down-regulation and positive correlation with circ_CDR1as."	0.4685
40658180	Human cell	2025	Activation of the circAGFG1/miR-195-5p/PD-L1 axis induces lung injury in sepsis.		circAGFG1	hsa_circ_AGFG1	AGFG1	sepsis-induced acute lung injury	MONDO:0015796	acute lung injury	down-regulated	RT-qPCR; Microarray	"circAGFG1 is down-regulated in peripheral blood from sepsis/ALI-related patient groups. Functionally, circAGFG1 sponges miR-195-5p to relieve repression of PD-L1, thereby reducing inflammatory cytokines, suppressing Th17 differentiation, and promoting epithelial cell survival in sepsis-induced ALI models."	0.7422
40661956	Frontiers in immunology	2025	circ-0001875 downregulation is associated with M1 macrophage activation and lung inflammation in severe asthma.	hsa_circ_0001875	circ-0001875	hsa_circ_FAM120A	FAM120A	asthma	MONDO:0004979	asthma	down-regulated	RT-qPCR; RNA-seq	"circ-0001875 is down-regulated in PBMCs of asthma patients (especially severe asthma) and in an OVA-LPS mouse model. It suppresses M1 macrophage polarization and airway/lung inflammation by sponging miR-31-5p, thereby promoting SP1 translation and inhibiting NF-kappaB pathway activation."	0.7129
40662137	Frontiers in cardiovascular medicine	2025	Microarray profile of circular RNAs identifies CBT15_circR_28491 and T helper cells as new regulators for deep vein thrombosis.		CBT15_circR_28491	rno_circ_CBT15		Deep Vein Thrombosis / DVT	MONDO:0005399	venous thromboembolism	down-regulated	RT-qPCR; Microarray	"CBT15_circR_28491 is down-regulated in a rat DVT model and is proposed (via predicted miRNA targeting) to regulate Kif18a/Cdca8/Nek2 through rno-miR-139-3p, implicating a circRNA_miRNA_mRNA axis linked to cell-cycle-related hub genes in DVT."	0.5623
40662137	Frontiers in cardiovascular medicine	2025	Microarray profile of circular RNAs identifies CBT15_circR_28491 and T helper cells as new regulators for deep vein thrombosis.		CBT15_circR_6215	rno_circ_CBT15		Deep Vein Thrombosis / DVT	MONDO:0005399	venous thromboembolism	down-regulated	RT-qPCR; Microarray	"CBT15_circR_6215 is significantly down-regulated in blood from the DVT rat model (validated by RT-qPCR), but no specific miRNA/target axis or functional mechanism for this circRNA is established in the paper."	0.3684
40662137	Frontiers in cardiovascular medicine	2025	Microarray profile of circular RNAs identifies CBT15_circR_28491 and T helper cells as new regulators for deep vein thrombosis.		CBT15_circR_10888	rno_circ_CBT15		Deep Vein Thrombosis / DVT	MONDO:0005399	venous thromboembolism	up-regulated	RT-qPCR; Microarray	"CBT15_circR_10888 is significantly up-regulated in blood from the DVT rat model (validated by RT-qPCR), but the study does not provide a specific downstream miRNA/target mechanism for this circRNA."	0.3684
40662137	Frontiers in cardiovascular medicine	2025	Microarray profile of circular RNAs identifies CBT15_circR_28491 and T helper cells as new regulators for deep vein thrombosis.		CBT15_circR_40191	rno_circ_CBT15		Deep Vein Thrombosis / DVT	MONDO:0005399	venous thromboembolism	up-regulated	RT-qPCR; Microarray	"CBT15_circR_40191 is significantly up-regulated in blood from the DVT rat model (validated by RT-qPCR), but the paper does not define a specific molecular mechanism or target axis for this circRNA."	0.3684
40662732	mBio	2025	Interferon-stimulated circHOMER1 attenuates antiviral innate immunity.	hsa_circ_0006916	circHOMER1	hsa_circ_HOMER1	HOMER1	virus-induced infection	MONDO:0005108	viral infectious disease	up-regulated	RT-qPCR; Microarray	"circHOMER1 is induced by viral infection and type I interferons and acts as a negative regulator of antiviral innate immunity. It suppresses type I IFN signaling and promotes viral replication by sponging miR-145-3p to increase OTUD7B and reduce IRF3, and by binding G3BP1 to disrupt G3BP1_RIG-I complex formation, impairing RIG-I viral RNA sensing."	0.7962
40662732	mBio	2025	Interferon-stimulated circHOMER1 attenuates antiviral innate immunity.	mmu_circ_0000491	circHomer1	mmu_circ_Homer1	HOMER1	virus-induced infection	MONDO:0005108	viral infectious disease	up-regulated	RT-qPCR	"Mouse circHomer1 is induced during viral infection and, when overexpressed in a VSV infection model, suppresses type I IFN responses, increases viral load in multiple organs, and worsens lung pathology, supporting an immunosuppressive role in antiviral innate immunity in vivo."	0.5798
40663488	JCI insight	2025	NSD1-916aa encoded by CircNSD1 contributes to AKI-to-CKD transition through inducing ferroptosis in tubular epithelial cells.		CircNSD1	hsa_circ_NSD1	NSD1	acute kidney injury / AKI	MONDO:0002492	acute kidney injury	down-regulated	RT-qPCR; ISH; RNA-seq	"CircNSD1 is down-regulated during AKI-to-CKD transition in mouse models and in post-AKI patient samples. CircNSD1 overexpression suppresses tubular epithelial ferroptosis and reduces downstream inflammation and fibrosis, partly by lowering ACSL4 and SLC39A14 via altered H3K36 methylation; it also encodes a peptide (NSD1-916aa) that may contribute to these effects."	0.8473
40663488	JCI insight	2025	NSD1-916aa encoded by CircNSD1 contributes to AKI-to-CKD transition through inducing ferroptosis in tubular epithelial cells.		CircNSD1	mmu_circ_NSD1	NSD1	acute kidney injury / AKI	MONDO:0002492	acute kidney injury	down-regulated	RT-qPCR; ISH; RNA-seq	"CircNSD1 is down-regulated during AKI-to-CKD transition in mouse models and in post-AKI patient samples. CircNSD1 overexpression suppresses tubular epithelial ferroptosis and reduces downstream inflammation and fibrosis, partly by lowering ACSL4 and SLC39A14 via altered H3K36 methylation; it also encodes a peptide (NSD1-916aa) that may contribute to these effects."	0.8473
40663488	JCI insight	2025	NSD1-916aa encoded by CircNSD1 contributes to AKI-to-CKD transition through inducing ferroptosis in tubular epithelial cells.	mmu_circ_0000465	CircNsd1	mmu_circ_Nsd1	Nsd1	acute kidney injury / AKI	MONDO:0002492	acute kidney injury	down-regulated	RT-qPCR; ISH; RNA-seq	"Mouse CircNsd1 (mmu_circ_0000465) is reduced after renal I/R injury and, when overexpressed by AAV delivery, alleviates renal ferroptosis and decreases inflammation and fibrosis, thereby inhibiting AKI-to-CKD transition."	0.7242
40664766	Scientific reports	2025	CircRNA ZFR promotes cell progression by regulating miR-96a-5p/SLC1A1 axis in hepatocellular carcinoma.	hsa_circ_0072088	circRNA ZFR / circ-0072088	hsa_circ_ZFR	ZFR	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH	"circRNA ZFR (circZFR; hsa-circ_0072088) is up-regulated in HCC plasma/blood, tumor tissues, and HCC cell lines. Functionally, circZFR promotes HCC proliferation, migration, invasion and in vivo tumor progression, mainly by sponging miR-96a-5p and relieving repression of SLC1A1, forming the circZFR/miR-96a-5p/SLC1A1 axis."	0.7375
40665223	BMC cancer	2025	Enhanced tumor suppression in patient-derived temozolomide-resistant glioblastoma cells using a combination treatment of Olaparib and FK866.	hsa_circ_0001200	circPTTG1IP	hsa_circ_PTTG1IP	PTTG1IP	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; RNA-seq	"In TMZ-resistant glioblastoma models, circPTTG1IP is upregulated upon Olaparib-containing treatment and modulates NAMPT expression, NAD+ levels, and PARP1 PARylation. Its level negatively correlates with Olaparib sensitivity and can be used as a predictive marker for response to the Olaparib/FK866/TMZ cocktail, potentially via a miRNA-mediated mechanism involving hsa-miR-671-5p."	0.6616
40665444	European journal of medical research	2025	Whole transcriptome sequencing to uncover CircRNA expression patterns linked to schizophrenia pathogenesis.	hsa_circ_0006157		hsa_circ_RICTOR	RICTOR	schizophrenia / SCZ	MONDO:0005090	schizophrenia	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0006157 is up-regulated in SCZ patient PBMCs and was validated by RT-qPCR in an independent cohort. It shows diagnostic potential by ROC analysis, and bioinformatics predicts it may interact with RBPs such as DDX54 and RBM15B."	0.5047
40665444	European journal of medical research	2025	Whole transcriptome sequencing to uncover CircRNA expression patterns linked to schizophrenia pathogenesis.	hsa_circ_0071422		hsa_circ_SH3RF1	SH3RF1	schizophrenia / SCZ	MONDO:0005090	schizophrenia	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0071422 is up-regulated in SCZ patient PBMCs and was validated by RT-qPCR in a 40 vs 40 cohort. It shows the best diagnostic performance among the three validated circRNAs by ROC analysis, and is predicted to bind RBPs including DDX54 and RBM15B."	0.5047
40665444	European journal of medical research	2025	Whole transcriptome sequencing to uncover CircRNA expression patterns linked to schizophrenia pathogenesis.	hsa_circ_0071095		hsa_circ_SLC10A7	SLC10A7	schizophrenia / SCZ	MONDO:0005090	schizophrenia	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0071095 is up-regulated in SCZ patient PBMCs and was validated by RT-qPCR in an independent cohort. It has diagnostic biomarker potential by ROC analysis and is predicted to bind RBPs including DDX54 and RBM15B; its host gene is SLC10A7.	0.5047
40666104	Frontiers in oncology	2025	Hsa_circ_0001859 promotes NSCLC progression through the miRNA-101-3p/MMP1 axis.	hsa_circ_0001859	Circ_0001859 / circRNA_001859			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0001859 is up-regulated in NSCLC tissues/cell lines and mainly localized in the cytoplasm. It promotes malignant phenotypes (proliferation, migration, invasion, EMT and tumor growth) by sponging miR-101-3p to increase MMP1 expression, forming a circ_0001859/miR-101-3p/MMP1 regulatory axis."	0.7094
40670591	Scientific reports	2025	Exploring a circulating circRNA and miRNA biomarker panel for early detection of ovarian cancer through multiple omics analysis.	hsa_circ_0049101		hsa_circ_MUC16	MUC16	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0049101 (host gene MUC16) is up-regulated in ovarian cancer and increases with clinical stage in patient plasma. It is part of a multi-marker CMD panel and shows strong diagnostic performance by ROC analysis; mechanistically it was included in predicted circRNA_miRNA_mRNA (ceRNA) networks (e.g., with hsa-miR-330-5p)."	0.6548
40670591	Scientific reports	2025	Exploring a circulating circRNA and miRNA biomarker panel for early detection of ovarian cancer through multiple omics analysis.	hsa_circ_0007440		hsa_circ_CTNNA1	CTNNA1	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; RNA-seq; Microarray	"hsa_circ_0007440 (host gene CTNNA1) is up-regulated in ovarian cancer across tissue and plasma validations and is included in a CMD diagnostic panel with strong ROC performance. It participates in predicted ceRNA axes, notably hsa_circ_0007440_hsa-miR-338-3p_RIMS1."	0.6841
40670591	Scientific reports	2025	Exploring a circulating circRNA and miRNA biomarker panel for early detection of ovarian cancer through multiple omics analysis.	hsa_circ_0006935		hsa_circ_PAPSS1	PAPSS1	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; RNA-seq; Microarray	"hsa_circ_0006935 (host gene PAPSS1) is up-regulated in ovarian cancer across GEO tissue validation and patient plasma, and is part of a CMD diagnostic panel with high ROC AUC. It is included in predicted ceRNA networks, notably hsa_circ_0006935_hsa-miR-338-3p_CBL."	0.6841
40671099	Cancer cell international	2025	EIF4A3-induced circPRKAR1B promotes esophageal squamous cell carcinoma progression through binding PKM2 to regulate NF-kappaB induced CCL3 secretion.		circPRKAR1B	hsa_circ_PRKAR1B	PRKAR1B	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; ISH	"circPRKAR1B is upregulated in ESCC tissues/cells and promotes proliferation, migration, invasion, and in vivo tumor growth/metastasis. It binds PKM2 to activate NF-kappaB signaling and increase CCL3 secretion, and its biogenesis is promoted by EIF4A3 binding to flanking sequences. High circPRKAR1B expression is associated with poor overall survival and adverse clinicopathologic features in ESCC."	0.8637
40673270	Frontiers in cell and developmental biology	2025	Overexpression of GDF15 protects kidneys from ischemia reperfusion injury and affects circular RNA expression.		circRNA Smad3 / circSmad3	mmu_circ_Smad3	SMAD3	renal ischemia reperfusion injury / renal IRI	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR	"In a mouse renal ischemia-reperfusion injury model, circSmad3 is up-regulated in injured kidneys, and its increase is attenuated by GDF15 overexpression. The study also computationally predicts a circSmad3-associated circRNA_miRNA_gene network, but does not experimentally validate specific targets or functions."	0.31
40673270	Frontiers in cell and developmental biology	2025	Overexpression of GDF15 protects kidneys from ischemia reperfusion injury and affects circular RNA expression.		circRNA Hipk3 / circHipk3	mmu_circ_Hipk3	HIPK3	renal ischemia reperfusion injury / renal IRI	MONDO:0005203	ischemia reperfusion injury	down-regulated	RT-qPCR	"In mouse renal ischemia-reperfusion injury, circHipk3 is down-regulated in injured kidneys and its decrease is attenuated by GDF15 overexpression. The study provides RT-qPCR evidence for differential expression and a predicted circHipk3_miRNA_gene network without functional validation."	0.31
40673270	Frontiers in cell and developmental biology	2025	Overexpression of GDF15 protects kidneys from ischemia reperfusion injury and affects circular RNA expression.		circRNA Crim1 / circCrim1	mmu_circ_Crim1	CRIM1	renal ischemia reperfusion injury / renal IRI	MONDO:0005203	ischemia reperfusion injury	down-regulated	RT-qPCR	"In mouse renal ischemia-reperfusion injury, circCrim1 is down-regulated in injured kidneys and its decrease is attenuated by GDF15 overexpression. A predicted circCrim1_miRNA_gene network is provided, but no direct mechanistic/functional experiments are performed for circCrim1."	0.31
40678515	iScience	2025	CircYAP1 inhibits osteosarcoma progression through the miR-135b-5p/FRK axis.	hsa_circ_0002320	circYAP1	hsa_circ_YAP1	YAP1	osteosarcoma / OS	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; ISH	"circYAP1 is down-regulated in osteosarcoma and acts as a tumor suppressor by inhibiting proliferation, invasion, migration, and lung metastasis. Mechanistically, it functions as a ceRNA that sponges miR-135b-5p to upregulate the tumor-suppressor FRK. Low circYAP1 expression is associated with metastatic status, advanced clinical stage, and worse overall survival."	0.8107
40683918	Scientific reports	2025	"The circDUSP1/miR-429/DLC1 regulatory network affects proliferation, migration, and invasion of triple-negative breast cancer cells."	hsa_circ_0075043	circDUSP1	hsa_circ_DUSP1	DUSP1	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	down-regulated	RT-qPCR	"circDUSP1 is down-regulated in TNBC tissues and cell lines and acts as a tumor suppressor. It predominantly localizes in the cytoplasm and sponges miR-429, thereby de-repressing and upregulating the tumor suppressor DLC1, leading to inhibition of TNBC cell proliferation, migration, invasion, and xenograft tumor growth."	0.8355
40684174	Molecular cancer	2025	CircABCA1 promotes ccRCC by reprogramming cholesterol metabolism and facilitating M2 macrophage polarization through IGF2BP3-mediated stabilization of SCARB1 mRNA.	hsa_circ_0087805	circABCA1	hsa_circ_ABCA1	ABCA1	clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR; Microarray	"circABCA1 is upregulated in ccRCC and promotes tumor growth and metastasis by increasing cholesterol uptake and reducing cholesterol efflux. Mechanistically, circABCA1 binds IGF2BP3 and cooperates to stabilize SCARB1 mRNA, sustaining lipid rafts and activating IGF1R/PI3K/AKT/mTOR signaling to suppress lipophagy, while also fostering a cholesterol-depleted microenvironment that promotes M2 macrophage polarization."	0.848
40684181	Cell & bioscience	2025	"Circ_HUWE1: a novel regulator of lipid accumulation, inflammation, and gut microbiota in atherosclerosis."	hsa_circ_0090695	circ_HUWE1	hsa_circ_HUWE1	HUWE1	atherosclerosis / AS	MONDO:0005311	atherosclerosis	down-regulated	RT-qPCR; RNA-seq	"circ_HUWE1 is downregulated in CAD/atherosclerosis and exerts anti-atherosclerotic effects by reducing lipid accumulation, plaque formation, macrophage infiltration, and inflammatory cytokines. Mechanistically, it acts as a ceRNA that sponges miR-143-3p to upregulate IGFBP5, and it is associated with restoration of beneficial gut microbiota in HFD-fed ApoE_/_ mice."	0.7745
40686389	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2025	SenExo-cCCT2 Reprograms Senescence Response and Anti-Tumor Immunity Following FOLFIRINOX Chemotherapy in Pancreatic Ductal Adenocarcinoma.	hsa_circ_0002940	cCCT2 / SenExo-cCCT2	hsa_circ_CCT2	CCT2	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"In PDAC, cCCT2 (hsa_circ_0002940) is upregulated in chemotherapy-responsive cases and promotes FOLFIRINOX-induced senescence and chemosensitivity by impairing SLX4-dependent DNA damage repair via IPO13/UBC9-regulated SUMOylation. Senescent tumor cells secrete CXCL10 to recruit CD8+ T-cells but also upregulate PD-L1, enabling immune escape; sequential anti-PD-L1 therapy restores cytotoxic function. SenExo-cCCT2 is an exosome-based delivery strategy to exploit these effects therapeutically."	0.8988
40688325	Journal of thoracic disease	2025	Transcriptome sequencing showed the differential expression of circRNAs in human pulmonary microvascular endothelial cells in acute respiratory distress syndrome.	hsa_circ_0038113	hsa-circRNA-0038113			acute respiratory distress syndrome / ARDS	MONDO:0006502	acute respiratory distress syndrome	up-regulated	RT-qPCR; RNA-seq	"hsa-circRNA-0038113 was identified as significantly upregulated in an in vitro ARDS model (LPS-challenged HPMECs) by RNA-seq and validated by RT-qPCR. It was highlighted among the most changed circRNAs and suggested to be relevant to endothelial permeability and potential ARDS biomarker discovery, though no specific miRNA/mRNA targets were reported for this circRNA."	0.2465
40688325	Journal of thoracic disease	2025	Transcriptome sequencing showed the differential expression of circRNAs in human pulmonary microvascular endothelial cells in acute respiratory distress syndrome.	hsa_circ_0027446	hsa-circRNA-0027446			acute respiratory distress syndrome / ARDS	MONDO:0006502	acute respiratory distress syndrome	up-regulated	RT-qPCR; RNA-seq	"hsa-circRNA-0027446 was identified as significantly upregulated in LPS-challenged HPMECs (in vitro ARDS model) by RNA-seq and validated by RT-qPCR. It was among the most upregulated circRNAs and was discussed as part of a set of circRNAs potentially relevant to endothelial permeability and ARDS biomarker development, without a circRNA-specific downstream axis provided."	0.2465
40688325	Journal of thoracic disease	2025	Transcriptome sequencing showed the differential expression of circRNAs in human pulmonary microvascular endothelial cells in acute respiratory distress syndrome.	hsa_circ_0000528	hsa-circRNA-0000528			acute respiratory distress syndrome / ARDS	MONDO:0006502	acute respiratory distress syndrome	up-regulated	RT-qPCR; RNA-seq	"hsa-circRNA-0000528 was found upregulated in LPS-challenged HPMECs (an in vitro ARDS model) and was included among the top upregulated circRNAs validated by RT-qPCR. The study suggests such differentially expressed circRNAs may relate to endothelial permeability regulation and potential ARDS biomarker development, but provides no circRNA-specific target axis for this circRNA."	0.2465
40688325	Journal of thoracic disease	2025	Transcriptome sequencing showed the differential expression of circRNAs in human pulmonary microvascular endothelial cells in acute respiratory distress syndrome.	hsa_circ_0084037	hsa-circRNA-0084037			acute respiratory distress syndrome / ARDS	MONDO:0006502	acute respiratory distress syndrome	up-regulated	RT-qPCR; RNA-seq	"hsa-circRNA-0084037 was identified as upregulated in LPS-induced HPMECs (in vitro ARDS model) and included among the top upregulated circRNAs validated by RT-qPCR. The paper frames these markedly changed circRNAs as potentially involved in endothelial permeability regulation and as candidate diagnostic biomarkers, without specifying a unique downstream mechanism for this circRNA."	0.2465
40688325	Journal of thoracic disease	2025	Transcriptome sequencing showed the differential expression of circRNAs in human pulmonary microvascular endothelial cells in acute respiratory distress syndrome.	hsa_circ_0085782	hsa-circRNA-0085782			acute respiratory distress syndrome / ARDS	MONDO:0006502	acute respiratory distress syndrome	up-regulated	RT-qPCR; RNA-seq	"hsa-circRNA-0085782 was significantly upregulated in LPS-treated HPMECs (in vitro ARDS model) and was among the top changed circRNAs validated by RT-qPCR. The study suggests that highly dysregulated circRNAs may contribute to endothelial permeability changes and could be useful as ARDS diagnostic biomarkers, but no specific interaction axis was assigned to this circRNA."	0.2465
40688325	Journal of thoracic disease	2025	Transcriptome sequencing showed the differential expression of circRNAs in human pulmonary microvascular endothelial cells in acute respiratory distress syndrome.	hsa_circ_0029398				acute respiratory distress syndrome / ARDS	MONDO:0006502	acute respiratory distress syndrome	down-regulated	RT-qPCR; RNA-seq	"hsa-circRNA-0029398 was selected as one of the most downregulated circRNAs in LPS-challenged HPMECs (in vitro ARDS model) and was included in RT-qPCR validation. The study broadly links major circRNA expression changes to endothelial permeability regulation and potential biomarker value, but does not provide a circRNA-specific regulatory axis for this circRNA."	0.2465
40688325	Journal of thoracic disease	2025	Transcriptome sequencing showed the differential expression of circRNAs in human pulmonary microvascular endothelial cells in acute respiratory distress syndrome.	hsa_circ_0004956	hsa-circRNA-0004956			acute respiratory distress syndrome / ARDS	MONDO:0006502	acute respiratory distress syndrome	down-regulated	RT-qPCR; RNA-seq	"hsa-circRNA-0004956 was identified as significantly downregulated in LPS-challenged HPMECs (in vitro ARDS model) via RNA-seq and validated by RT-qPCR. It was included among circRNAs suggested to relate to endothelial permeability regulation and diagnostic biomarker potential in ARDS, without an explicit circRNA-specific mechanistic axis."	0.2465
40688325	Journal of thoracic disease	2025	Transcriptome sequencing showed the differential expression of circRNAs in human pulmonary microvascular endothelial cells in acute respiratory distress syndrome.	hsa_circ_0008126	hsa-circRNA-0008126			acute respiratory distress syndrome / ARDS	MONDO:0006502	acute respiratory distress syndrome	down-regulated	RT-qPCR; RNA-seq	"hsa-circRNA-0008126 was significantly downregulated in the LPS-induced HPMEC ARDS model and was among circRNAs validated by RT-qPCR. The paper positions markedly changed circRNAs as potentially important for endothelial permeability control and ARDS biomarker discovery, without detailing a specific ceRNA axis for this circRNA."	0.2465
40688325	Journal of thoracic disease	2025	Transcriptome sequencing showed the differential expression of circRNAs in human pulmonary microvascular endothelial cells in acute respiratory distress syndrome.	hsa_circ_0003972	hsa-circRNA-0003972			acute respiratory distress syndrome / ARDS	MONDO:0006502	acute respiratory distress syndrome	down-regulated	RT-qPCR; RNA-seq	"hsa-circRNA-0003972 was identified as downregulated in the LPS-challenged HPMEC ARDS model and included among circRNAs validated by RT-qPCR. It is part of the set of circRNAs proposed to be relevant to vascular permeability changes and biomarker discovery in ARDS, without an explicit circRNA-specific interaction mechanism reported."	0.2465
40688325	Journal of thoracic disease	2025	Transcriptome sequencing showed the differential expression of circRNAs in human pulmonary microvascular endothelial cells in acute respiratory distress syndrome.	hsa_circ_0119881	hsa-circRNA-0119881			acute respiratory distress syndrome / ARDS	MONDO:0006502	acute respiratory distress syndrome	down-regulated	RT-qPCR; RNA-seq	"hsa-circRNA-0119881 was significantly downregulated in LPS-challenged HPMECs (in vitro ARDS model) and included among the top downregulated circRNAs validated by RT-qPCR. The paper suggests that circRNAs with the greatest expression changes may be involved in regulating endothelial permeability and could be ARDS biomarkers, without providing a specific downstream interaction network for this circRNA."	0.2465
40691637	Journal of hematology & oncology	2025	Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study.		circCSNK1G3	hsa_circ_CSNK1G3	CSNK1G3	chronic lymphocytic leukemia / CLL	MONDO:0003864	chronic lymphocytic leukemia/small lymphocytic lymphoma	down-regulated	RT-qPCR; RNA-seq	"circCSNK1G3 is significantly decreased in malignant cells from both t(14;19) CLL and CLL without t(14;19) compared with healthy B cells, representing a common circRNA dysregulation in CLL."	0.3588
40691637	Journal of hematology & oncology	2025	Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study.		circEXOC6B(3_5)	hsa_circ_EXOC6B	EXOC6B	chronic lymphocytic leukemia / CLL	MONDO:0003864	chronic lymphocytic leukemia/small lymphocytic lymphoma	down-regulated	RNA-seq	circEXOC6B(3_5) is depleted (reduced expression) in CLL malignant cells compared with healthy B cells based on RNA-seq profiling.	0.1155
40691637	Journal of hematology & oncology	2025	Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study.		circZNF609	hsa_circ_ZNF609	ZNF609	chronic lymphocytic leukemia / CLL	MONDO:0003864	chronic lymphocytic leukemia/small lymphocytic lymphoma	up-regulated	RNA-seq	circZNF609 is overexpressed in CLL malignant B cells compared with healthy B cells based on RNA-seq profiling.	0.1155
40691637	Journal of hematology & oncology	2025	Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study.		circLPAR3	hsa_circ_LPAR3	LPAR3	chronic lymphocytic leukemia / CLL	MONDO:0003864	chronic lymphocytic leukemia/small lymphocytic lymphoma	up-regulated	RT-qPCR; RNA-seq	"circLPAR3 is significantly increased in CLL malignant cells in both t(14;19) and non-t(14;19) CLL groups compared with healthy B cells, supported by RNA-seq and RT-qPCR validation."	0.3588
40691637	Journal of hematology & oncology	2025	Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study.		circCDK14(3_4)	hsa_circ_CDK14	CDK14	chronic lymphocytic leukemia / CLL	MONDO:0003864	chronic lymphocytic leukemia/small lymphocytic lymphoma	up-regulated	RT-qPCR; RNA-seq	"circCDK14(3_4) is increased in CLL compared with healthy B cells, and shows a stronger upregulation in the t(14;19) CLL subgroup; it is among validated circRNAs included in survival analysis."	0.4679
40691637	Journal of hematology & oncology	2025	Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study.		circCORO1C	hsa_circ_CORO1C	CORO1C	chronic lymphocytic leukemia / CLL	MONDO:0003864	chronic lymphocytic leukemia/small lymphocytic lymphoma	up-regulated	RT-qPCR; RNA-seq	"circCORO1C is specifically overexpressed in t(14;19) CLL compared with healthy B cells (validated by RT-qPCR). High circCORO1C expression predicts worse outcomes, including shorter time to first treatment and overall survival."	0.4679
40691637	Journal of hematology & oncology	2025	Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study.		circCLEC2D	hsa_circ_CLEC2D	CLEC2D	chronic lymphocytic leukemia / CLL	MONDO:0003864	chronic lymphocytic leukemia/small lymphocytic lymphoma	up-regulated	RT-qPCR; RNA-seq	"circCLEC2D is specifically overexpressed in t(14;19) CLL compared with healthy B cells (validated by RT-qPCR). High circCLEC2D expression is associated with worse clinical outcomes, including shorter time to first treatment and overall survival."	0.4679
40691637	Journal of hematology & oncology	2025	Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study.		circEMB	hsa_circ_EMB	EMB	chronic lymphocytic leukemia / CLL	MONDO:0003864	chronic lymphocytic leukemia/small lymphocytic lymphoma	up-regulated	RT-qPCR; RNA-seq	circEMB is significantly overexpressed in the t(14;19) CLL subgroup compared with healthy B cells (RT-qPCR validated). Its expression level shows association with time to first treatment in univariate analysis.	0.4679
40691637	Journal of hematology & oncology	2025	Circular RNA signature of aggressive CLL with t(14;19)(q32;q13). An ERIC study.		circCEP70(3_6) / circCEP70	hsa_circ_CEP70	CEP70	chronic lymphocytic leukemia / CLL	MONDO:0003864	chronic lymphocytic leukemia/small lymphocytic lymphoma	down-regulated	RT-qPCR; RNA-seq	circCEP70(3_6) is specifically downregulated in t(14;19) CLL compared with healthy B cells (RT-qPCR validated). Its expression level is associated with time to first treatment in univariate analysis.	0.4679
40701248	The Journal of biological chemistry	2025	A novel protein encoded by circTUBGCP3 blocks ferroptosis and promotes gastric cancer progression.	hsa_circ_0000504	circTUBGCP3	hsa_circ_TUBGCP3	TUBGCP3	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circTUBGCP3 is up-regulated in gastric cancer and promotes proliferation, migration, and xenograft growth. It encodes TUBGCP3-230aa, which stabilizes ENO1 and modulates AMPK/system Xc-/GPX4 signaling to enhance glycolysis and inhibit ferroptosis."	0.8768
40702555	Journal of translational medicine	2025	Hypoxic cancer-associated fibroblast exosomal circSTAT3 drives triple negative breast cancer stemness via miR-671-5p/NOTCH1 signaling.	hsa_circ_0043800	circSTAT3	hsa_circ_STAT3	STAT3	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"Hypoxic CAF-derived exosomes deliver circSTAT3 into TNBC cells, where circSTAT3 functions as a ceRNA to sponge miR-671-5p and derepress NOTCH1. This promotes EMT, stemness (e.g., ALDH1A1/CD44), tumor growth, and cisplatin chemoresistance, and circSTAT3 is elevated in tumors and patient plasma exosomes, supporting biomarker potential."	0.84
40702809	Cancer science	2025	CircCDYL Association With hnRNPL Modulates CDYL Isoform Switching in Breast Cancer Cells.		circCDYL / hsa_CDYL_0005	hsa_circ_CDYL	CDYL	breast cancer / BC	MONDO:0007254	breast cancer	unknown	RT-qPCR; RNA-seq	"In MCF-7 breast cancer cells, circCDYL associates with the splicing factor hnRNPL and contributes to widespread alternative splicing changes. circCDYL also regulates its host gene CDYL by influencing isoform selection mainly through alternative promoter usage and chromatin remodeling at CDYL promoter regions, with involvement of ERalpha occupancy."	0.6475
40707002	The Journal of biological chemistry	2025	WTAP-mediated m6A methylation of circRNA_404908 promotes esophageal squamous cell carcinoma progression.	hsa_circ_4040908	circRNA_4040908	hsa_circ_PPME1	PPME1	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"In ESCC, circRNA_404908 is up-regulated and promotes malignant phenotypes including proliferation, migration, and invasion. WTAP-mediated m6A methylation increases circRNA_404908 stability/expression, and circRNA_404908 functions as a ceRNA to sponge miR-3059-5p, thereby upregulating ANO1 to drive ESCC progression."	0.8729
40708910	Frontiers in genetics	2025	Circ-malat1 promotes gastric cell growth via miR-154-5p/CCND2.	hsa_circ_0002082	circ-malat1		malat1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"Circ-malat1 is up-regulated in gastric cancer cells and promotes cell growth/proliferation. It mainly localizes in the cytoplasm and functions as a ceRNA that sponges miR-154-5p, thereby increasing CCND2 expression to drive gastric carcinogenesis."	0.7626
40709841	Journal of clinical laboratory analysis	2025	Serum Circ-DLGAP4 and miR-9 as Potential Biomarkers in Pancreatic Cancer.		Circ_DLGAP4 / circular RNA DLGAP4	hsa_circ_DLGAP4	DLGAP4	pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"Circ-DLGAP4 is significantly up-regulated in the serum of pancreatic cancer patients versus healthy controls and shows strong diagnostic performance by ROC analysis. Its serum level is positively correlated with miR-9, but no functional mechanism was experimentally investigated in this study."	0.4187
40711603	Clinical and experimental medicine	2025	Combined bulk and single-cell transcriptomic analysis reveals cell-type-specific inflammatory crosstalk in pancreatic cancer.		circRNA_102049			pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	unknown	RNA-seq; Microarray	"The paper mentions circRNA_102049 in a previously reported ceRNA axis (circRNA_102049/miR-455-3p/CD80) related to immune modulation and tumor progression in PDAC context, but does not present original expression or validation data for this circRNA."	0.1904
40711603	Clinical and experimental medicine	2025	Combined bulk and single-cell transcriptomic analysis reveals cell-type-specific inflammatory crosstalk in pancreatic cancer.	hsa_circ_0004200				pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	unknown	Microarray	"hsa_circ_0004200 (also referred to as circ_chr15_00053) was prioritized in a computationally built ceRNA network for PDAC and suggested to act as a regulatory circRNA via predicted miRNA interactions, but without experimental validation or a specified direction of dysregulation in the provided text."	0.1768
40711603	Clinical and experimental medicine	2025	Combined bulk and single-cell transcriptomic analysis reveals cell-type-specific inflammatory crosstalk in pancreatic cancer.	hsa_circ_0007883	circANKRD17	hsa_circ_ANKRD17	ANKRD17	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	unknown	Microarray	"hsa_circ_0007883 (circANKRD17) was prioritized by network centrality in a computational ceRNA network for PDAC and proposed to regulate PDAC biology via predicted miRNA interactions, but no experimental validation or PDAC-specific functional assays are reported in the provided text."	0.1768
40711603	Clinical and experimental medicine	2025	Combined bulk and single-cell transcriptomic analysis reveals cell-type-specific inflammatory crosstalk in pancreatic cancer.	hsa_circ_0003528	circSEC24A	hsa_circ_SEC24A	SEC24A	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	unknown	Microarray	"hsa_circ_0003528 (circSEC24A) was identified computationally as a PDAC-related circRNA within a predicted ceRNA network, implying miRNA-mediated regulation, but PDAC-specific expression direction and experimental validation are not provided in the text."	0.1768
40711603	Clinical and experimental medicine	2025	Combined bulk and single-cell transcriptomic analysis reveals cell-type-specific inflammatory crosstalk in pancreatic cancer.	hsa_circ_0092314	circRANBP1	hsa_circ_RANBP1	RANBP1	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	unknown	Microarray	"hsa_circ_0092314 (circRANBP1) was identified computationally as a PDAC-associated circRNA within a predicted ceRNA network, implying miRNA-mediated regulation; however, the provided text does not report direction of dysregulation or experimental validation."	0.1768
40711603	Clinical and experimental medicine	2025	Combined bulk and single-cell transcriptomic analysis reveals cell-type-specific inflammatory crosstalk in pancreatic cancer.	hsa_circ_0001789	circRAB11FIP1	hsa_circ_RAB11FIP1	RAB11FIP1	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	unknown	Microarray	"hsa_circ_0001789 (circRAB11FIP1) was identified computationally as a PDAC-associated circRNA in a predicted ceRNA network, suggesting miRNA-mediated regulation, but PDAC-specific expression direction and experimental validation are not reported in the provided text."	0.1768
40713692	Hereditas	2025	Local anesthetic ropivacaine inhibits non-small cell lung cancer progression by modulating the hsa_circ_0001320/miR-518a-5p axis.	hsa_circ_0001320	circ_0001320			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	"circ_0001320 is down-regulated in NSCLC tissues and cell lines and is induced by ropivacaine. Functionally, circ_0001320 mediates ropivacaine's anti-tumor effects by targeting and suppressing miR-518a-5p, thereby inhibiting proliferation/migration/invasion/angiogenesis and promoting apoptosis in NSCLC cells."	0.6815
40713830	Journal of experimental & clinical cancer research : CR	2025	A novel polypeptide encoded by circSPIRE1 promotes prostate cancer proliferation and migration by restraining the ubiquitin-dependent degradation of LRP5.	hsa_circ_0000829	circSPIRE1	hsa_circ_SPIRE1	SPIRE1	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; ISH; Microarray	"circSPIRE1 is up-regulated in prostate cancer and promotes proliferation, migration and invasion. It is translated via an IRES-dependent rolling circle mechanism regulated by hnRNPA1 SDMA modification to generate rtSPIRE1, which stabilizes LRP5 by inhibiting ubiquitination and thereby activates PI3K/AKT/mTOR signaling and EMT."	0.8817
40715337	Scientific reports	2025	Reprogramming of hsa_circ_0008719 and its target miR-3615 induced by TOB1 in exosomes of gastric cancer cells: a contribution to inhibit gastric cancer progression.	hsa_circ_0008719		hsa_circ_AKT2	AKT2	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; RNA-seq	"In gastric cancer, hsa_circ_0008719 is down-regulated in patient tumor tissues but is upregulated by TOB1 in gastric cancer cells/exosomes. It localizes mainly in the cytoplasm and acts as a sponge for miR-3615; exosomal delivery of hsa_circ_0008719 suppresses proliferation and enhances autophagy in recipient gastric cancer cells."	0.8035
40718834	Frontiers in oncology	2025	The impact of circWWC3 on neoadjuvant therapy for triple-negative breast cancer and the construction of a nomogram for predicting pathological complete response after neoadjuvant therapy.		circular RNA WWC3 / circWWC3	hsa_circ_WWC3	WWC3	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	ISH	"In TNBC patients receiving neoadjuvant therapy, circWWC3 shows predominantly cytoplasmic localization and high expression in most tumor samples. High circWWC3 expression is strongly associated with and independently predicts achieving pathological complete response, and it was incorporated into a nomogram with TILs and deltaADC 0-2% to predict pCR."	0.5121
40724645	"Life (Basel, Switzerland)"	2025	Profiling Plant circRNAs Provides Insights into the Expression of Plant Genes Involved in Viral Infection.		circRNA2			Turnip rosette virus (TRoV) infection; Rice yellow mottle virus (RYMV) transgenic (non-host viral condition); scLTSV (circ-LTSV) transgenic	Plant diseases		dysregulated	RT-qPCR; RNA-seq	"circRNA2 shows condition-dependent dysregulation in Arabidopsis thaliana under viral infection/transgenic viral-component contexts: increased in RYMV-, circ-LTSV-, and CP-TRoV-transgenic plants but decreased in TRoV-infected plants. It is described as related to oxidoreductase and cytochrome complex assembly, suggesting involvement in stress-linked cellular processes."	0.585
40724645	"Life (Basel, Switzerland)"	2025	Profiling Plant circRNAs Provides Insights into the Expression of Plant Genes Involved in Viral Infection.		circRNA205 / ATCG00020	ath_circ_ATCG00020	ATCG00020	Rice yellow mottle virus (RYMV) transgenic (non-host viral condition); Turnip rosette virus (TRoV) related transgenic conditions	Plant diseases		up-regulated	RT-qPCR; RNA-seq	"circRNA205 (ATCG00020) is induced under the non-host viral condition (RYMV transgenic Arabidopsis), with RNA-seq showing counts in RYMV while absent in control and CP-TRoV/scLTSV samples. It contains an ORF, suggesting potential translation into a protein with reported similarity to a monooxygenase-related wheat protein."	0.4761
40724645	"Life (Basel, Switzerland)"	2025	Profiling Plant circRNAs Provides Insights into the Expression of Plant Genes Involved in Viral Infection.		circRNA291 / AT1G01520	ath_circ_AT1G01520	AT1G01520	plant viral infection / plant_virus interactions	Plant diseases		unknown	RNA-seq	circRNA291 (AT1G01520) is bioinformatically predicted in this study to function as a miRNA decoy for ath-miR396b-5p in Arabidopsis under viral-related experimental conditions. The work reports prediction-based evidence without dedicated experimental validation for this specific circRNA.	0.1768
40724645	"Life (Basel, Switzerland)"	2025	Profiling Plant circRNAs Provides Insights into the Expression of Plant Genes Involved in Viral Infection.		circRNA236 / AT5G10550	ath_circ_AT5G10550	AT5G10550	plant viral infection / plant_virus interactions	Plant diseases		unknown	RNA-seq	"circRNA236 (AT5G10550) is predicted to function as a miRNA decoy targeting ath-miR167a-5p and ath-miR167b in the study¡¯s computational circRNA_miRNA network related to plant viral stress contexts, without direct experimental validation for this interaction."	0.1768
40724645	"Life (Basel, Switzerland)"	2025	Profiling Plant circRNAs Provides Insights into the Expression of Plant Genes Involved in Viral Infection.		circRNA296 / AT3G60240 (eIF4G)	ath_circ_AT3G60240	AT3G60240 (eIF4G)	Rice yellow mottle virus (RYMV) transgenic (non-host viral condition)	Plant diseases		up-regulated	RT-qPCR; RNA-seq	"circRNA296 derived from AT3G60240 (eIF4G) is specifically detected in the RYMV-transgenic (non-host) Arabidopsis condition, suggesting viral RNA presence can selectively induce host translation-factor-related circRNA expression. The study validates its circular nature and expression via sequencing and qPCR-based assays."	0.4761
40724645	"Life (Basel, Switzerland)"	2025	Profiling Plant circRNAs Provides Insights into the Expression of Plant Genes Involved in Viral Infection.		ATCG00030 (ciRNA106) / ciRNA106	ath_circ_ATCG00030	ATCG00030	circLTSV (circ-LTSV) transgenic / virusoid expression (scLTSV)	Plant diseases		up-regulated	RNA-seq	"ciRNA106 (ATCG00030) is reported as specifically induced by exogenous non-coding circLTSV expression in Arabidopsis, and is discussed as part of uniquely expressed circRNAs that may contribute to resistance against TRoV infection, though mechanism is not established."	0.1768
40724645	"Life (Basel, Switzerland)"	2025	Profiling Plant circRNAs Provides Insights into the Expression of Plant Genes Involved in Viral Infection.		ATCG00130 (ciRNA11) / ciRNA11	ath_circ_ATCG00130	ATCG00130	circLTSV (circ-LTSV) transgenic / virusoid expression (scLTSV)	Plant diseases		dysregulated	RNA-seq	"ciRNA11 (ATCG00130) displays variable abundance across viral/transgenic conditions and is discussed as induced by exogenous circLTSV expression, potentially contributing to TRoV resistance; however, direct mechanistic validation is not provided for this specific circRNA."	0.1768
40724932	International journal of molecular sciences	2025	Overexpression of Circular PRMT1 Transcripts in Colorectal Adenocarcinoma Predicts Recurrence and Poor Overall Survival.		circ-PRMT1	hsa_circ_PRMT1	PRMT1	colorectal adenocarcinoma	MONDO:0005008	colorectal adenocarcinoma	up-regulated	RT-qPCR	"circ-PRMT1 (circular PRMT1 transcripts) is significantly up-regulated in colorectal adenocarcinoma tissues versus paired non-cancerous tissues. High circ-PRMT1 expression is associated with higher recurrence risk and independently predicts shorter DFS and OS, supporting its use as a prognostic biomarker in colorectal adenocarcinoma."	0.6201
40725099	International journal of molecular sciences	2025	Lead Induces Mitochondrial Dysregulation in SH-SY5Y Neuroblastoma Cells via a lncRNA/circRNA-miRNA-mRNA Interdependent Networks.	hsa_circ_0000330				lead exposure	MONDO:0018019	lead poisoning	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000330 is significantly up-regulated in Pb-treated SH-SY5Y cells and is included among validated differentially expressed circRNAs. The study suggests these Pb-responsive circRNAs may contribute to mitochondrial damage by modulating ceRNA networks, but no circ_0000330-specific downstream miRNA/mRNA axis is experimentally confirmed."	0.2465
40725099	International journal of molecular sciences	2025	Lead Induces Mitochondrial Dysregulation in SH-SY5Y Neuroblastoma Cells via a lncRNA/circRNA-miRNA-mRNA Interdependent Networks.	hsa_circ_0002544				lead exposure	MONDO:0018019	lead poisoning	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0002544 is significantly up-regulated after lead exposure in SH-SY5Y cells and was validated by qRT-PCR. The paper proposes that Pb-responsive circRNAs may affect mitochondrial damage through ceRNA network modulation, but does not experimentally define a specific downstream axis for hsa_circ_0002544."	0.2465
40725099	International journal of molecular sciences	2025	Lead Induces Mitochondrial Dysregulation in SH-SY5Y Neuroblastoma Cells via a lncRNA/circRNA-miRNA-mRNA Interdependent Networks.	hsa_circ_0007883				lead exposure	MONDO:0018019	lead poisoning	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0007883 is significantly up-regulated in Pb-treated SH-SY5Y cells and its expression change was validated by qRT-PCR. The study frames it as a Pb-responsive circRNA that may participate in ceRNA-mediated regulation related to mitochondrial damage, without defining a circ_0007883-specific miRNA/mRNA mechanism."	0.2465
40725099	International journal of molecular sciences	2025	Lead Induces Mitochondrial Dysregulation in SH-SY5Y Neuroblastoma Cells via a lncRNA/circRNA-miRNA-mRNA Interdependent Networks.	hsa_circ_0003511				lead exposure	MONDO:0018019	lead poisoning	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0003511 is significantly down-regulated after lead exposure in SH-SY5Y cells and was validated by qRT-PCR. The study suggests Pb-altered circRNAs may influence mitochondrial damage via ceRNA network modulation, but provides no circ_0003511-specific functional assays or downstream targets."	0.2465
40725099	International journal of molecular sciences	2025	Lead Induces Mitochondrial Dysregulation in SH-SY5Y Neuroblastoma Cells via a lncRNA/circRNA-miRNA-mRNA Interdependent Networks.	hsa_circ_0062659				lead exposure	MONDO:0018019	lead poisoning	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0062659 is significantly down-regulated upon Pb treatment in SH-SY5Y cells and was validated by qRT-PCR. It is discussed as part of Pb-altered circRNAs potentially contributing to mitochondrial damage via ceRNA-network modulation, but its specific interacting miRNAs/targets are not reported in text."	0.2465
40725099	International journal of molecular sciences	2025	Lead Induces Mitochondrial Dysregulation in SH-SY5Y Neuroblastoma Cells via a lncRNA/circRNA-miRNA-mRNA Interdependent Networks.	hsa_circ_0109371				lead exposure	MONDO:0018019	lead poisoning	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0109371 is significantly down-regulated in Pb-exposed SH-SY5Y cells and was validated by qRT-PCR. The study broadly suggests Pb-altered circRNAs may contribute to mitochondrial damage via ceRNA networks, but does not report a specific mechanism for hsa_circ_0109371."	0.2465
40726542	Neuropsychiatric disease and treatment	2025	Construction and Brain Validation of circRNAs-miRNAs-mRNAs Regulatory Axis in Early-Onset Schizophrenia.	hsa_circ_0000713 	hsa-circ-NFATC3	hsa_circ_NFATC3	NFATC3	early-onset schizophrenia / EOS	MONDO:0019939	early-onset schizophrenia	up-regulated	RT-qPCR	"In early-onset schizophrenia, hsa-circ-0000713 (from NFATC3) is up-regulated and acts as a ceRNA sponge for hsa-miR-370-3p, thereby relieving repression of ANK3 and MGLL. The axis shows consistent expression changes in patient blood plasma and in rat prefrontal cortex in MAM and Poly I:C models, suggesting involvement in abnormal prefrontal cortex development and EOS pathogenesis."	0.7289
40728965	Current issues in molecular biology	2025	The Construction of ceRNA Regulatory Network Unraveled Prognostic Biomarkers and Repositioned Drug Candidates for the Management of Pancreatic Ductal Adenocarcinoma.		hsa_circRNA_102465			Pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	dysregulated	Microarray	This study identified hsa_circRNA_102465 as a PDAC-associated differentially expressed circRNA and a key node (signal distributor) in a PDAC-specific ceRNA network. It is predicted to participate in circRNA_miRNA_mRNA regulatory axes involving PDAC-relevant miRNAs and hub genes.	0.1768
40728965	Current issues in molecular biology	2025	The Construction of ceRNA Regulatory Network Unraveled Prognostic Biomarkers and Repositioned Drug Candidates for the Management of Pancreatic Ductal Adenocarcinoma.		hsa_circRNA_100904			Pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	dysregulated	Microarray	This study identified hsa_circRNA_100904 as a PDAC-associated differentially expressed circRNA and a key node (signal distributor) in a PDAC-specific ceRNA network. It is implicated in predicted circRNA_miRNA_mRNA regulatory relationships with PDAC-relevant miRNAs and hub genes.	0.1768
40730815	Cell death discovery	2025	A novel protein encoded by circUBE2G1 suppresses glycolysis in gastric cancer through binding to ENO1.	hsa_circ_0003239	CircUBE2G1	hsa_circ_UBE2G1	UBE2G1	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"circUBE2G1 is down-regulated in gastric cancer and acts as a tumor suppressor mainly through encoding the microprotein circUBE2G1-99aa. circUBE2G1-99aa binds ENO1, inhibits ENO1 enzymatic activity, suppresses glycolysis, and dampens PI3K/AKT signaling, thereby inhibiting proliferation and metastatic phenotypes in vitro and in vivo; low circUBE2G1 is linked to worse clinicopathological features and poorer survival."	0.7716
40735833	"Journal of cachexia, sarcopenia and muscle"	2025	CircGLIS3 Inhibits Intramuscular Adipogenesis and Alleviates Skeletal Muscle Fat Infiltration.		circGLIS3 / circRNA32	bta_circ_GLIS3	GLIS3	skeletal muscle fat infiltration	MONDO:0020120	skeletal muscle disorder	up-regulated	RT-qPCR; RNA-seq	"circGLIS3 is a GLIS3-derived circRNA that inhibits intramuscular adipogenic differentiation and reduces high-fat-diet-induced skeletal muscle fat infiltration. It primarily functions as a ceRNA that sponges miR-21-3p, thereby increasing LEPR and activating AMPK signaling to suppress adipogenesis-related programs."	0.8062
40739313	Scientific reports	2025	Association of Hsa_circ_0059511 with the sensitivity of the temozolomide chemotherapeutic treatment in human glioma cells.	hsa_circ_0059511	circ0059511 / circ_0059511			glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; Microarray	"circ0059511 is up-regulated in TMZ-resistant glioblastoma/glioma and promotes TMZ chemoresistance. It acts as a ceRNA to sponge miR-194-5p, thereby relieving repression of FZD6 and supporting proliferation and invasive behaviors under TMZ; circ0059511 knockdown sensitizes tumors/cells to TMZ in vitro and in xenografts."	0.7376
40740985	Oncology letters	2025	circEFR3A promotes breast cancer progression by sponging miR-590-3p to upregulate androgen receptor expression.	hsa_circ_0006522	circEFR3A	hsa_circ_EFR3A	EFR3A	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; ISH	"circEFR3A (hsa_circ_0006522), derived from EFR3A, is up-regulated in breast cancer and mainly localized in the cytoplasm. It promotes proliferation, migration, invasion and xenograft tumor growth by sponging miR-590-3p to de-repress/upregulate AR, and high circEFR3A is associated with poorer overall survival."	0.8757
40741237	Archives of medical science : AMS	2025	Downregulation of circ_0119412 expression inhibits malignant progression of breast cancer by targeting the miR-1205/GALNT6 pathway in vivo and in vitro.	hsa_circ_0119412	circ_0119412 / circRNA_0119412	hsa_circ_PER2	PER2	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0119412 is up-regulated in breast cancer tissues and cell lines and mainly localizes to the cytoplasm. Its knockdown suppresses proliferation/invasion, increases apoptosis, and inhibits xenograft tumor growth by acting as a ceRNA that sponges miR-1205 to relieve repression of GALNT6."	0.762
40744997	Experimental & molecular medicine	2025	Extracellular vesicle-mediated delivery of circp53 suppresses the progression of multiple cancers by activating the CypD/TRAP/HSP90 pathway.	hsa_circ_0041947	hsa_circp53_0041947 / circp53	hsa_circ_TP53	TP53	multiple myeloma / MM	MONDO:0009693	plasma cell myeloma	down-regulated	RT-qPCR; ISH; RNA-seq	"TP53-derived circp53 (hsa_circp53_0041947) is down-regulated in MM (and reduced in CRC tissues). Increasing circp53 suppresses proliferation and induces mitochondrial apoptosis by encoding the peptide circp53_209aa, which binds CypD and disrupts the CypD/TRAP1/HSP90 complex to trigger mPTP opening. Engineered EVs delivering circp53 show tumor-targeted inhibitory effects in MM and CRC models, and higher circp53 expression in MM correlates with longer overall survival."	0.8557
40745648	Journal of experimental & clinical cancer research : CR	2025	Endoplasmic reticulum-localized circular RNA FAM13B restrains nasopharyngeal carcinoma lymphatic metastasis through downregulating XBP1.		circFAM13B	hsa_circ_FAM13B	FAM13B	nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	down-regulated	RT-qPCR; RNA-seq	"circFAM13B is downregulated in lymph node-metastatic nasopharyngeal carcinoma and functions as a tumor suppressor. It localizes to the ER and binds RBM3 to enhance RBM3-mediated uXBP1 mRNA decay, reducing sXBP1 activity and CST6 expression/secretion, thereby inhibiting lymphangiogenesis and lymphatic metastasis. High circFAM13B expression is associated with better patient prognosis."	0.8941
40746530	Frontiers in immunology	2025	Exosome circ-CBLB promotes M1 macrophage polarization in rheumatoid arthritis through the TLR3/TRAF3 signaling axis.		circ-CBLB / circCBLB	hsa_circ_CBLB	CBLB	rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	down-regulated	RT-qPCR	"circ-CBLB is down-regulated in RA and is packaged into exosomes from RA-FLS. Exosomal circ-CBLB binds TLR3 and suppresses the TLR3/TRAF3 (TBK1/IRF3) signaling cascade, thereby inhibiting M1 macrophage polarization and reducing inflammatory cytokine production."	0.7537
40758712	PloS one	2025	Hsa_circ_0006834 represses intrahepatic cholangiocarcinoma proliferation through activating AMPK-mTOR pathway and autophagy via has-miR-637-NGFR network.	hsa_circ_0006834				intrahepatic cholangiocarcinoma / ICC	MONDO:0003210	intrahepatic cholangiocarcinoma	down-regulated	RT-qPCR	"hsa_circ_0006834 is down-regulated in iCCA and suppresses iCCA cell proliferation, migration and invasion by promoting autophagy. Mechanistically, it sponges miR-637 to upregulate NGFR, which activates AMPK and inhibits mTOR signaling."	0.5925
40768899	Redox biology	2025	Extracellular vesicle-mediated delivery of mitochondrial circRNA MTCO2 protects against cerebral ischemia by modulating mPTP-dependent ferroptosis.		circMTCO2 / circRNA MTCO2	mmu_circ_MTCO2	MTCO2	ischemic stroke / IS	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR; RNA-seq	"circMTCO2 is a mitochondria-encoded circRNA that is down-regulated after cerebral ischemia/reperfusion. It directly binds ANT1 to inhibit mPTP opening, suppress mtROS release, and thereby reduce neuronal ferroptosis and ischemic brain injury; targeted EV delivery restores circMTCO2 in neuronal mitochondria and improves outcomes in a tMCAO mouse model."	0.7742
40770637	Journal of nanobiotechnology	2025	N6-methyladenosine-modified circDCP2 promotes carbon black nanoparticle-induced malignancy in human bronchial epithelial cells via PI3K-AKT pathway and macrophage homeostasis.	hsa_circ_0073608	circDCP2	hsa_circ_DCP2	DCP2	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circDCP2 (hsa_circ_0073608) is up-regulated in CBNP-transformed BEAS-2B cells and in clinical lung cancer tissues, and promotes tumorigenic phenotypes (proliferation, migration, invasion and xenograft growth). WTAP-mediated m6A modification enables circDCP2 to interact with HnRNPA2B1 to stabilize CCND1 mRNA and activate PI3K/AKT signaling, and to interact with IGF2BP3 to enhance STAT3 activation (JAK/STAT), cytokine secretion and M2-like TAM polarization."	0.8462
40778323	Biochemistry and biophysics reports	2025	Molecular profiling of rheumatoid Arthritis: Expression dynamics of hsa_circ_0092125 and G6PD in an integrative gene expression study.	hsa_circ_0092125	hsa_circRNA_105041 / hsa_circG6PD_014	hsa_circ_G6PD	G6PD	Rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0092125 is significantly up-regulated in PBMCs from RA patients and shows moderate diagnostic value. The study¡¯s predicted ceRNA network suggests it may modulate immune-inflammatory gene expression, potentially via sponging miRNAs and affecting downstream mRNAs (including its host gene G6PD)."	0.5047
40780118	"Clinics (Sao Paulo, Brazil)"	2025	hsa_circ_0002872 functions in lung cancer prognostic and tumorigenesis through regulating ZBTB46 via sponging hsa-miR-29b-1-5p.	hsa_circ_0002872		hsa_circ_PTPRM	PTPRM	lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0002872 is down-regulated in lung cancer tissues versus adjacent tissues. The study predicts a ceRNA axis where hsa_circ_0002872 sponges hsa-miR-29b-1_5p to regulate ZBTB46, potentially influencing lung cancer progression."	0.4032
40780118	"Clinics (Sao Paulo, Brazil)"	2025	hsa_circ_0002872 functions in lung cancer prognostic and tumorigenesis through regulating ZBTB46 via sponging hsa-miR-29b-1-5p.	hsa_circ_0135681		hsa_circ_MTSS1	MTSS1	lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0135681 is down-regulated in lung cancer tissues compared with adjacent tissues, and this change was consistent between RNA-seq and qRT-PCR validation. No downstream miRNA/mRNA axis or functional assays were reported for hsa_circ_0135681 in this study."	0.3588
40781640	Journal of orthopaedic surgery and research	2025	Circular RNA GCLC promotes osteogenic differentiation of bone marrow mesenchymal stem cells via modulating miR-516b-5p/GNAS axis.		circular RNA GCLC / circGCLC	hsa_circ_GCLC	GCLC	Osteoporosis / OP	MONDO:0005298	osteoporosis	unknown	RT-qPCR	"circGCLC promotes osteogenic differentiation of human BMSCs by acting as a ceRNA that sponges miR-516b-5p, thereby relieving repression of GNAS. This axis enhances MAPK pathway activation (p-JNK, p-p38) and increases osteogenic markers and mineralization."	0.5871
40784450	The Journal of biological chemistry	2025	A non-coding RNA circGNAI2 suppresses triple-negative breast cancer progression by sponging miR-454-3p to inhibit the VGLL4-STAT3 signaling.	hsa_circ_0007083	circGNAI2 / cirGNAI2	hsa_circ_GNAI2	GNAI2	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	down-regulated	RT-qPCR; Microarray	"circGNAI2 (hsa_circ_0007083), derived from GNAI2, is down-regulated in TNBC tissues and cell lines and acts as a tumor suppressor. It sponges miR-454-3p to increase VGLL4 and reduce STAT3 phosphorylation, thereby inhibiting TNBC cell proliferation/migration and suppressing xenograft tumor growth; its biogenesis is negatively regulated by EIF4A3."	0.8613
40784956	Scientific reports	2025	CAFs exosomal circFOXO1 promotes TNBC autophagy and radioresistance via miR-27a-3p/BNIP3 axis.		circFOXO1 / circRNA-FOXO1	hsa_circ_FOXO1	FOXO1	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"This study shows that CAF-derived exosomal circRNA-FOXO1 is increased after radiotherapy and promotes TNBC cell proliferation, migration/invasion, EMT and autophagy while inhibiting apoptosis. Mechanistically, circRNA-FOXO1 sponges miR-27a-3p to regulate BNIP3, resulting in enhanced autophagy and reduced radiosensitivity in TNBC."	0.5634
40794423	The Journal of international medical research	2025	CircDock6 drives metabolic dysfunction-associated steatotic liver disease progression in mice and mouse hepatocytes via mmu-let-7g-5p/insulin-like growth factor 1 receptor regulation.		circDock6	mmu_circ_Dock6	Dock6	metabolic-associated fatty liver disease / MAFLD	MONDO:0013209	metabolic dysfunction-associated steatotic liver disease	up-regulated	RT-qPCR	"circDock6 is up-regulated in HFD-induced MASLD mouse liver and promotes steatosis in AML-12 hepatocytes. It acts as a sponge for mmu-let-7g-5p, thereby regulating IGF1R expression and contributing to MASLD progression."	0.568
40801354	The Journal of international medical research	2025	Differentially expressed circular RNAs and their diagnostic value in children with allergic rhinitis.	hsa_circ_0008999	hsa_circRNA_0008999	hsa_circ_EED	EED	allergic rhinitis / AR	MONDO:0011786	allergic rhinitis	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_0008999 is significantly down-regulated in peripheral blood of children with allergic rhinitis. A circRNA_miRNA_mRNA network was computationally constructed suggesting a potential miRNA-sponge role, but no specific miRNAs/mRNAs were experimentally validated and no clinical correlation with symptom score or total IgE was observed."	0.5135
40801354	The Journal of international medical research	2025	Differentially expressed circular RNAs and their diagnostic value in children with allergic rhinitis.	hsa_circ_0059181	hsa_circRNA_0059181 / circ_0059181	hsa_circ_FKBP1A	FKBP1A	allergic rhinitis / AR	MONDO:0011786	allergic rhinitis	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_0059181 is significantly up-regulated in peripheral blood of children with allergic rhinitis and its expression correlates positively with total symptom score and total serum IgE, supporting biomarker potential. A computational circRNA_miRNA_mRNA network suggests a miRNA-sponge (ceRNA) role and mentions miR-211-5p and miR-145 as predicted targets, but direct mechanistic validation was not performed."	0.5135
40801445	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2025	m6A-Modified circRAPGEF1 Interaction with IGF2BP3 Promotes Hepatocellular Carcinoma Progression via Reprogramming Aspartate Metabolism.	hsa_circ_0089254	circRAPGEF1	hsa_circ_RAPGEF1	RAPGEF1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"circRAPGEF1 is upregulated in HCC/LCSCs and promotes stemness, proliferation, and tumorigenicity while decreasing sorafenib sensitivity. METTL3 installs m6A on circRAPGEF1 enabling IGF2BP3 binding to stabilize it; circRAPGEF1 then competitively sequesters IGF2BP3 from ASS1 mRNA, destabilizing ASS1, increasing aspartate and activating S6K/CAD signaling to drive HCC progression."	0.8939
40801613	Cells	2025	circSATB1 Modulates Cell Senescence in Age-Related Acute Myeloid Leukemia: A Mechanistic Proposal.		circSATB1	hsa_circ_SATB1	SATB1	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; RNA-seq	"circSATB1 is up-regulated in elderly AML peripheral blood samples and AML cell lines. circSATB1 knockdown inhibits proliferation, causes G0/G1 arrest, and promotes telomere-independent premature cellular senescence. Predicted networks suggest possible interactions with miR-450b-5p/miR-452-5p and several RBPs, but these mechanisms were not experimentally validated."	0.728
40804612	BMC cancer	2025	CircMORC1 downregulated in plasma EVs promotes gastric cancer cell proliferation and invasion via miR-103a-1-5p sponging.	hsa_circ_0141931	circMORC1	hsa_circ_MORC1	MORC1	gastric cancer / GC	MONDO:0001056	gastric cancer	dysregulated	RT-qPCR; RNA-seq	"circMORC1 shows opposite expression trends in GC: decreased in plasma EVs but increased in GC cells. It promotes GC cell proliferation/viability and migration/invasion and inhibits apoptosis by sponging miR-103a-1-5p, thereby affecting Wnt/beta-catenin pathway activity and related targets (e.g., TCF7, Wnt11). It is proposed as a plasma EV biomarker for GC diagnosis/prognosis."	0.7759
40817234	BMC biology	2025	m6A-modified circZNF548 regulates exosomal miR-7108-3p to activate CD3+CD8+ T cells and suppress NSCLC growth by JMY.		circZNF548	hsa_circ_ZNF548	ZNF548	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; ISH; Microarray	"circZNF548 is down-regulated in NSCLC and acts as a tumor suppressor. It sponges miR-7108-3p and lowers exosomal miR-7108-3p, thereby increasing JMY and activating p53-dependent apoptosis while enhancing CD8+ T-cell cytotoxicity, which together inhibit NSCLC growth and migration."	0.8793
40821807	Frontiers in immunology	2025	Identification of circRNA expression signatures correlated with disease severity in pediatric systemic lupus erythematosus.	hsa_circ_0034298			Null	systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	down-regulated	RNA-seq	"hsa_circ_0034298 is significantly down-regulated in PBMCs when comparing mild vs moderate pediatric SLE and was evaluated as a severity biomarker, but its expression was not significantly correlated with SLEDAI in this cohort."	0.348
40821807	Frontiers in immunology	2025	Identification of circRNA expression signatures correlated with disease severity in pediatric systemic lupus erythematosus.	hsa_circ_0035301		hsa_circ_PRKAR2B	PRKAR2B	systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	down-regulated	RNA-seq	"hsa_circ_0035301 is down-regulated in PBMCs in mild vs moderate pediatric SLE and was evaluated for severity prediction, but ROC analysis indicated it did not show significant diagnostic value in this comparison."	0.348
40821807	Frontiers in immunology	2025	Identification of circRNA expression signatures correlated with disease severity in pediatric systemic lupus erythematosus.	hsa_circ_0041622		hsa_circ_TXLNGY	TXLNGY	systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	down-regulated	RNA-seq	"hsa_circ_0041622 is down-regulated in PBMCs in mild vs moderate pediatric SLE and was identified via RNA-seq as a candidate circRNA signature component potentially useful for severity assessment, without mechanistic validation."	0.348
40821807	Frontiers in immunology	2025	Identification of circRNA expression signatures correlated with disease severity in pediatric systemic lupus erythematosus.	hsa_circ_0012520			Null	systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	down-regulated	RNA-seq	"hsa_circ_0012520 is down-regulated in PBMCs in mild vs moderate pediatric SLE and was evaluated for severity prediction; however, ROC analysis suggested it did not have significant diagnostic value in this cohort comparison."	0.348
40821807	Frontiers in immunology	2025	Identification of circRNA expression signatures correlated with disease severity in pediatric systemic lupus erythematosus.	hsa_circ_0014642		hsa_circ_PIGN	PIGN	systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	down-regulated	RNA-seq	"hsa_circ_0014642 is down-regulated in PBMCs in mild vs moderate pediatric SLE and was proposed as part of a severity-associated circRNA signature, but showed no significant correlation with SLEDAI score in this cohort."	0.1768
40821807	Frontiers in immunology	2025	Identification of circRNA expression signatures correlated with disease severity in pediatric systemic lupus erythematosus.	hsa_circ_0034385		hsa_circ_RPL10A	RPL10A	systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	up-regulated	RNA-seq	"hsa_circ_0034385 is up-regulated in PBMCs in mild vs moderate pediatric SLE and was identified by RNA-seq as a candidate circRNA associated with disease severity, without mechanistic validation."	0.348
40821807	Frontiers in immunology	2025	Identification of circRNA expression signatures correlated with disease severity in pediatric systemic lupus erythematosus.	hsa_circ_0017898		hsa_circ_ELK4	ELK4	systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	up-regulated	RNA-seq	"hsa_circ_0017898 is up-regulated in PBMCs in mild vs moderate pediatric SLE and was identified by RNA-seq as a candidate circRNA associated with severity, without mechanistic validation."	0.348
40821807	Frontiers in immunology	2025	Identification of circRNA expression signatures correlated with disease severity in pediatric systemic lupus erythematosus.	hsa_circ_0005890		hsa_circ_POC1B	POC1B	systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	up-regulated	RNA-seq	"hsa_circ_0005890 is up-regulated in PBMCs in mild vs moderate pediatric SLE and was evaluated for severity prediction; however, ROC analysis suggested it did not have significant diagnostic value in this cohort comparison."	0.348
40821807	Frontiers in immunology	2025	Identification of circRNA expression signatures correlated with disease severity in pediatric systemic lupus erythematosus.	hsa_circ_0034305			Null	systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	up-regulated	RNA-seq	"hsa_circ_0034305 is up-regulated in PBMCs in mild vs moderate pediatric SLE and was identified by RNA-seq as a candidate circRNA associated with disease severity, without mechanistic validation."	0.348
40821807	Frontiers in immunology	2025	Identification of circRNA expression signatures correlated with disease severity in pediatric systemic lupus erythematosus.	hsa_circ_0031868		hsa_circ_UIMC1	UIMC1	systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	up-regulated	RNA-seq	"hsa_circ_0031868 is up-regulated in PBMCs in mild vs moderate pediatric SLE and was identified by RNA-seq as a candidate circRNA associated with disease severity, without mechanistic validation."	0.348
40821807	Frontiers in immunology	2025	Identification of circRNA expression signatures correlated with disease severity in pediatric systemic lupus erythematosus.	hsa_circ_0017675			Null	systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	down-regulated	RNA-seq	"hsa_circ_0017675 is down-regulated in PBMCs in severe vs moderate pediatric SLE and was identified by RNA-seq among the top severity-associated circRNAs, with ROC analysis supporting its potential diagnostic value for distinguishing severity groups."	0.348
40821807	Frontiers in immunology	2025	Identification of circRNA expression signatures correlated with disease severity in pediatric systemic lupus erythematosus.	hsa_circ_0013503		hsa_circ_ANKRD36B	ANKRD36B	systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	down-regulated	RNA-seq	hsa_circ_0013503 is down-regulated in PBMCs in severe vs moderate pediatric SLE and was identified by RNA-seq among top severity-associated circRNAs; ROC analysis at the panel level supports diagnostic potential for severity stratification.	0.348
40821807	Frontiers in immunology	2025	Identification of circRNA expression signatures correlated with disease severity in pediatric systemic lupus erythematosus.	hsa_circ_0013852		hsa_circ_CEP70	CEP70	systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	down-regulated	RNA-seq	hsa_circ_0013852 is down-regulated in PBMCs in severe vs moderate pediatric SLE and was identified by RNA-seq among top severity-associated circRNAs; ROC analysis at the set level supports diagnostic value for severity stratification.	0.348
40821807	Frontiers in immunology	2025	Identification of circRNA expression signatures correlated with disease severity in pediatric systemic lupus erythematosus.	hsa_circ_0003563		hsa_circ_PPP2R5C	PPP2R5C	systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	down-regulated	RNA-seq	hsa_circ_0003563 is down-regulated in PBMCs in severe vs moderate pediatric SLE and was identified by RNA-seq among top severity-associated circRNAs; ROC analysis at the set level supports diagnostic value for severity stratification.	0.348
40821807	Frontiers in immunology	2025	Identification of circRNA expression signatures correlated with disease severity in pediatric systemic lupus erythematosus.	hsa_circ_0000612		hsa_circ_PARGP1	PARGP1	systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	down-regulated	RNA-seq	hsa_circ_0000612 is down-regulated in PBMCs in severe vs moderate pediatric SLE and was identified by RNA-seq among top severity-associated circRNAs; ROC analysis at the set level supports diagnostic value for severity stratification.	0.348
40821807	Frontiers in immunology	2025	Identification of circRNA expression signatures correlated with disease severity in pediatric systemic lupus erythematosus.	hsa_circ_0011482			Null	systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	up-regulated	RNA-seq	"hsa_circ_0011482 is up-regulated in PBMCs in severe vs moderate pediatric SLE and was assessed for prognostic relevance, but its expression did not significantly correlate with SLEDAI score in this dataset."	0.1768
40821807	Frontiers in immunology	2025	Identification of circRNA expression signatures correlated with disease severity in pediatric systemic lupus erythematosus.	hsa_circ_0003621			Null	systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	up-regulated	RNA-seq	hsa_circ_0003621 is up-regulated in PBMCs in severe vs moderate pediatric SLE and was identified by RNA-seq among top severity-associated circRNAs; ROC analysis at the set level supports diagnostic value for severity stratification.	0.348
40821807	Frontiers in immunology	2025	Identification of circRNA expression signatures correlated with disease severity in pediatric systemic lupus erythematosus.	hsa_circ_0019518		hsa_circ_VPS37A	VPS37A	systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	up-regulated	RNA-seq	hsa_circ_0019518 is up-regulated in PBMCs in severe vs moderate pediatric SLE and was identified by RNA-seq among top severity-associated circRNAs; ROC analysis at the set level supports diagnostic value for severity stratification.	0.348
40821807	Frontiers in immunology	2025	Identification of circRNA expression signatures correlated with disease severity in pediatric systemic lupus erythematosus.	hsa_circ_0008277			Null	systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	up-regulated	RNA-seq	hsa_circ_0008277 is up-regulated in PBMCs in severe vs moderate pediatric SLE and was identified by RNA-seq among top severity-associated circRNAs; ROC analysis at the set level supports diagnostic value for severity stratification.	0.348
40821807	Frontiers in immunology	2025	Identification of circRNA expression signatures correlated with disease severity in pediatric systemic lupus erythematosus.	hsa_circ_0008898			Null	systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	up-regulated	RNA-seq	hsa_circ_0008898 is up-regulated in PBMCs in severe vs moderate pediatric SLE and was identified by RNA-seq among top severity-associated circRNAs; ROC analysis at the set level supports diagnostic value for severity stratification.	0.348
40822008	Frontiers in cardiovascular medicine	2025	Expression profiles and bioinformatic analysis of circular RNA in rheumatic heart disease: potential hsa_circ_0001490 and hsa_circ_0001296 as a diagnostic biomarker.	hsa_circ_0001490	hsacirc0001490	hsa_circ_KIF2A	KIF2A	rheumatic heart disease / RHD	MONDO:0006955	rheumatic heart disease	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001490 is up-regulated in RHD patient plasma and shows diagnostic value by ROC analysis. Bioinformatic ceRNA network prediction links it to multiple miRNAs and hub genes (e.g., MED17/CDK8), with enrichment in Wnt, MAPK and TGF-beta/SMAD-related terms, suggesting potential involvement in RHD pathogenesis."	0.5047
40822008	Frontiers in cardiovascular medicine	2025	Expression profiles and bioinformatic analysis of circular RNA in rheumatic heart disease: potential hsa_circ_0001490 and hsa_circ_0001296 as a diagnostic biomarker.	hsa_circ_0001296	hsa_the circ_0001296	hsa_circ_SMARCC1	SMARCC1	rheumatic heart disease / RHD	MONDO:0006955	rheumatic heart disease	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001296 is up-regulated in RHD patient plasma and shows strong diagnostic performance by ROC analysis. Bioinformatic analyses predict a ceRNA network involving multiple miRNAs and hub genes, with enrichment in autophagy, MAPK and TGF-beta/SMAD-related functions, suggesting potential roles in RHD pathogenesis that require further experimental validation."	0.5047
40822457	Frontiers in pharmacology	2025	The functional roles of deoxyelephantopin potential target circTNPO3 in regulating pancreatic cancer malignant phenotype and gemcitabine chemoresistance via miR-188-5p/CDCA3/TRAF2-mediated remodeling of NF-kappaB signaling pathway.	hsa_circ_0001741	CircTNPO3 / Circ_0001741	hsa_circ_TNPO3	TNPO3	pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; ISH	"circTNPO3 is up-regulated in pancreatic cancer tissues/cells and is linked to worse overall survival and reduced gemcitabine sensitivity. It promotes malignant phenotypes and gemcitabine chemoresistance mainly by sponging miR-188-5p to derepress CDCA3, enhancing TRAF2 and NF-kappaB (p65) activation/nuclear translocation."	0.8933
40822904	iScience	2025	Biomarkers via liquid biopsy for distinguishing malignant from benign pulmonary ground-glass nodule.		cirUBXN7	hsa_circ_UBXN7	UBXN7	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	cirUBXN7 is up-regulated in peripheral blood/plasma of patients with malignant pulmonary GGNs compared with benign GGNs and healthy controls. It was selected as one of four ncRNAs in a logistic-regression biomarker panel that improves diagnostic discrimination of malignant vs benign GGNs and was validated in internal and external cohorts.	0.459
40823777	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2025	"Hsa_circ_0026782 Acts as a ""Molecular Break"" of CREB1-Mediated Transcription by Promoting Its Phosphorylation at Ser142 That Prevents Keloid Progression."	hsa_circ_0026782		hsa_circ_ITGA7	ITGA7	keloid	MONDO:0005348	keloid	down-regulated	RT-qPCR; Northern Blot; RNA-seq	"hsa_circ_0026782 (derived from ITGA7 exon 4) is down-regulated in keloid tissues. It suppresses keloid fibroblast proliferation/migration/invasion, promotes apoptosis, and inhibits xenograft keloid growth. Mechanistically, it binds CREB1 (via the 1_90 nt region) and promotes CREB1 Ser142 phosphorylation to reduce CREB1 transcriptional activity, downregulating CREB1 target genes such as DUSP9 and LDLR."	0.869
40826429	European journal of medical research	2025	Exploring the role of circ-GALK2 in vascular smooth muscle cell calcification: mechanisms and implications.	hsa_circ_0008488	circ-GALK2 / mmu-Galk2-0007	hsa_circ_GALK2	GALK2	vascular calcification / VC	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR; RNA-seq	"circ-GALK2 is upregulated during VSMC/vascular calcification and promotes calcification. It functions mainly as a ceRNA by sponging miR-134-3p, thereby increasing CD36 expression; this axis was supported in vitro, in a vitamin D3-induced mouse aortic calcification model, and by elevated plasma circ-GALK2 in patients with aortic calcification."	0.8097
40826429	European journal of medical research	2025	Exploring the role of circ-GALK2 in vascular smooth muscle cell calcification: mechanisms and implications.		circ-GALK2 / mmu-Galk2-0007	mmu_circ_GALK2	GALK2	vascular calcification / VC	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR; RNA-seq	"circ-GALK2 is upregulated during VSMC/vascular calcification and promotes calcification. It functions mainly as a ceRNA by sponging miR-134-3p, thereby increasing CD36 expression; this axis was supported in vitro, in a vitamin D3-induced mouse aortic calcification model, and by elevated plasma circ-GALK2 in patients with aortic calcification."	0.8097
40836210	BMC gastroenterology	2025	Hypoxia-induced exosomal circNRIP1 activates cancer-associated fibroblasts to promote esophageal squamous cell carcinoma migration and invasion.	hsa_circ_0004771	circNRIP1 / exo_circ_38881	hsa_circ_NRIP1	NRIP1	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"In ESCC, hypoxia increases circNRIP1 enrichment in tumor-cell-derived exosomes. Exosomal circNRIP1 is transferred into fibroblasts to activate a CAF-like phenotype and consequently promotes ESCC cell migration and invasion, mainly through binding and functionally depending on TRMT6."	0.7754
40841902	Molecular cancer	2025	CircZFR/YTHDF3 axis drives lymph node metastasis in cervical cancer via FASN translation.		circZFR	hsa_circ_ZFR	ZFR	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"In cervical cancer, circZFR is up-regulated and is associated with lymph node metastasis and shorter DFS. It promotes proliferation, migration/invasion and EMT by binding the m6A reader YTHDF3 to enhance m6A-dependent translation of FASN mRNA via recruitment of eIF4A3."	0.805
40842453	Brain circulation	2025	Expression profiles and potential clinical significance of circular RNAs in peripheral neutrophils of patients with intracranial atherosclerotic stenosis.		hsa-circRNA-087631			intracranial atherosclerotic stenosis / ICAS	MONDO:0011057	cerebrovascular disorder	up-regulated	RT-qPCR; Microarray	"hsa-circRNA-087631 is up-regulated in peripheral neutrophils of ICAS patients and its level decreases 24 h after endovascular treatment. It shows potential diagnostic value for ICAS and is higher in patients experiencing perioperative AE/SAE, suggesting utility for risk stratification; its mechanistic role is mainly supported by predicted ceRNA network analysis."	0.5047
40842453	Brain circulation	2025	Expression profiles and potential clinical significance of circular RNAs in peripheral neutrophils of patients with intracranial atherosclerotic stenosis.	hsa_circ_0005785	hsa-circRNA-101141	hsa_circ_APC7		intracranial atherosclerotic stenosis / ICAS	MONDO:0011057	cerebrovascular disorder	up-regulated	RT-qPCR; Microarray	"hsa-circRNA-101141 is up-regulated in peripheral neutrophils of ICAS patients and validated by qRT-PCR. It is associated with endovascular treatment status and perioperative AE/SAE, and shows high diagnostic performance by ROC analysis. Mechanistically, it is proposed to act via a ceRNA axis (notably hsa-miRNA-181d-5p) affecting actin/microtubule-related cytoskeleton organization processes in neutrophils."	0.5963
40842453	Brain circulation	2025	Expression profiles and potential clinical significance of circular RNAs in peripheral neutrophils of patients with intracranial atherosclerotic stenosis.		hsa-circRNA-100914			intracranial atherosclerotic stenosis / ICAS	MONDO:0011057	cerebrovascular disorder	down-regulated	RT-qPCR; Microarray	"hsa-circRNA-100914 is down-regulated in peripheral neutrophils of ICAS patients (microarray and qRT-PCR). It shows diagnostic potential by ROC analysis and is included as a core node in the predicted DEcircRNA-miRNA-mRNA network, but specific miRNA partners and downstream targets were not detailed in the text."	0.5047
40842453	Brain circulation	2025	Expression profiles and potential clinical significance of circular RNAs in peripheral neutrophils of patients with intracranial atherosclerotic stenosis.		hsa-circRNA-001082			intracranial atherosclerotic stenosis / ICAS	MONDO:0011057	cerebrovascular disorder	down-regulated	RT-qPCR; Microarray	"hsa-circRNA-001082 is down-regulated in peripheral neutrophils of ICAS patients (validated by qRT-PCR). It has potential diagnostic value for ICAS based on ROC analysis and is included in the predicted DEcircRNA-miRNA-mRNA network, but specific miRNA/mRNA partners were not specified in the text."	0.5047
40846151	Virus research	2025	Role of ebv-circRPMS1-p53 interaction in the proliferation and clinical progression of Epstein-Barr virus-associated gastric carcinoma.		ebv-circRPMS1 / circRPMS1		RPMS1	Epstein_Barr virus-associated gastric carcinoma / EBVaGC	MONDO:0017784	Epstein-Barr virus-associated gastric carcinoma	up-regulated	RT-qPCR; ISH	"ebv-circRPMS1 is up-regulated in EBV-positive gastric carcinoma/EBVaGC and promotes proliferation and tumor growth. It directly binds to and stabilizes/augments wild-type p53, converting p53 into a pro-tumorigenic collaborator. High ebv-circRPMS1 (especially with high p53) is associated with shorter overall survival, suggesting prognostic value in EBVaGC."	0.7982
40846892	Scientific reports	2025	Hsa_circ_0005571 promotes the proliferation and invasion of colorectal cancer cells.	hsa_circ_0005571	hsa_circRNA_0005571 / circ-0005571	hsa_circ_IFI30	IFI30	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0005571 is up-regulated in colorectal cancer tissues and cell lines and promotes CRC proliferation, migration/invasion, and xenograft tumor growth. Mechanistically, it acts as a ceRNA by sponging miR-520f-3p to increase LRP8 expression, and high hsa_circ_0005571 levels are associated with advanced stage/metastasis and worse overall survival."	0.7375
40861080	Cancer management and research	2025	Circ_CIT Promotes Nasopharyngeal Carcinoma Progression and Macrophage M2 Polarization Through miR-409-3p/ZEB1 Axis.	hsa_circ_0028705	circ_CIT	hsa_circ_CIT	CIT	nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"circ_CIT is up-regulated in nasopharyngeal carcinoma tissues and cell lines and functions as an oncogenic circRNA. It mainly localizes to the cytoplasm and promotes NPC cell proliferation/migration/invasion by sponging miR-409-3p to increase ZEB1 expression, and it enhances tumor-associated macrophage M2 polarization via the same axis."	0.807
40862172	Advanced biomedical research	2025	"MiR-15a-5p, c-MYB, and circHIPK3 Axis as a Potential Diagnostic and Clinicopathological-Related Network in Acute Myeloid Leukemia."	hsa_circ_0000284	circHIPK3 / circ-HIPK3	hsa_circ_HIPK3	HIPK3	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	down-regulated	RT-qPCR	"circ-HIPK3 is significantly down-regulated in AML patient BM/PB white blood cells and shows good diagnostic performance (AUC 0.762). It positively correlates with c-MYB within the proposed miR-15a-5p/c-MYB/circ-HIPK3 network, and circ-HIPK3 expression change is associated with RBC count."	0.559
40869968	Genes	2025	Circular RNA circ_0001591 Contributes to Melanoma Cell Migration Through AXL and FRA1 Proteins by Targeting miR-20a-3p and miR-34a-5p.	hsa_circ_0001591	circ_0001591	hsa_circ_H2AC11	H2AC11	melanoma	MONDO:0005105	melanoma	unknown	RT-qPCR	"circ_0001591 promotes melanoma cell migration by acting as a ceRNA sponge for miR-20a-3p and miR-34a-5p, which relieves repression of downstream targets and increases AXL and FRA1 (via FOSL1) protein levels. Its knockdown reduces migration in melanoma cell lines."	0.7076
40883663	Cellular & molecular biology letters	2025	Radiation-sensitive circRNA promotes intestinal regeneration.		"circDmbt1(3,4,5,6)"	mmu_circ_Dmbt1	Dmbt1	radiation-induced intestinal injury / RIII	MONDO:0043459	radiation-induced disorder	down-regulated	RT-qPCR; RNA-seq	"In a mouse model of radiation-induced intestinal injury, circDmbt1(3,4,5,6) is down-regulated after abdominal irradiation and its exogenous overexpression protects the intestine. It promotes epithelial/organoid proliferation, reduces apoptosis and DNA damage, mainly by sponging miR-125a-5p to derepress STAT3 signaling (circDmbt1(3,4,5,6)/miR-125a-5p/STAT3)."	0.8547
40890114	Cell death & disease	2025	MAP3K13-232aa encoded by circMAP3K13 enhances cisplatin-induced pyroptosis by directly binding to IKKalpha in gastric adenocarcinoma.		hsa_circ_11430 / circMAP3K13	hsa_circ_MAP3K13	MAP3K13	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; RNA-seq	"circMAP3K13 (hsa_circ_11430), derived from MAP3K13, is down-regulated in gastric cancer tissues/cell lines and suppresses malignant phenotypes. It functions largely by encoding the protein MAP3K13-232aa, which binds IKKalpha to activate NF-kappaB, upregulate NLRP3, and enhance (including cisplatin-induced) pyroptosis, reducing tumor growth and metastasis."	0.886
40896178	Regenerative therapy	2025	Extracellular vesicles-delivered circDB promotes ischemic muscle repair through the miR-34a/USP7/Notch1 signaling pathway.	hsa_circ_0025129	circDB	hsa_circ_TNFR1	TNFR1	limb ischemia	MONDO:0000491	limb ischemia	down-regulated	RT-qPCR	"EV-delivered circDB is down-regulated in ischemic hindlimb muscle but functionally promotes ischemic muscle regeneration. It sponges miR-34a to increase USP7, which deubiquitinates/stabilizes Notch1, thereby enhancing myoblast proliferation and improving hindlimb recovery."	0.5554
40896288	Journal of translational internal medicine	2025	CircPLK1 upregulates ETS1 to confer anthracycline resistance in triple-negative breast cancer.		circPLK1 / hsa_circ_038632	hsa_circ_PLK1	PLK1	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circPLK1 is upregulated in TNBC, especially in non-pCR patients after anthracyclines-based neoadjuvant chemotherapy. It promotes doxorubicin/anthracycline resistance by sponging miR-940 and thereby increasing ETS1 expression, leading to enhanced survival/colony formation and reduced apoptosis. High circPLK1 is associated with poorer DFS/OS and may serve as a prognostic/pharmacodynamic biomarker."	0.8711
40896579	Molecular therapy. Nucleic acids	2025	circARHGAP10 as a candidate biomarker and therapeutic target in myotonic dystrophy type 1.		circARHGAP10 / cARHGAP10	hsa_circ_ARHGAP10	ARHGAP10	myotonic dystrophy type 1 / DM1	MONDO:0008056	myotonic dystrophy type 1	up-regulated	RT-qPCR; RNA-seq	"circARHGAP10 is upregulated in DM1 skeletal muscle and shows biomarker potential (correlates with CTG repeat length and muscle strength; ROC AUC 0.86). Functionally, circARHGAP10 knockdown in DM1 myogenic cells reduces DMPK levels, decreases toxic nuclear RNA foci, and partially rescues missplicing, with effects mediated at least partly through interaction/co-regulation with miR-409-3p."	0.8635
40898233	Journal of translational medicine	2025	The circRNA-mediated ceRNA molecular regulatory network in fatigue-type type 2 diabete.	hsa_circ_0078539		hsa_circ_EZR	EZR	type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0078539 is up-regulated in F-T2DM and participates in an up-regulated ceRNA network. It likely acts as a miRNA sponge (e.g., hsa-mir-4695-3p) to de-repress SLC7A14, linking to altered energy metabolism and insulin signaling relevant to fatigue-type diabetes."	0.5922
40898233	Journal of translational medicine	2025	The circRNA-mediated ceRNA molecular regulatory network in fatigue-type type 2 diabete.	hsa_circ_0026239		hsa_circ_LARP4	LARP4	type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RNA-seq	hsa_circ_0026239 is up-regulated in F-T2DM relative to both controls and NF-T2DM. It is included in an up-regulated ceRNA axis (hsa_circ_0026239/hsa-mir-4310/TM4SF1) and is proposed as a potential molecular marker for fatigue-type diabetes.	0.1768
40898233	Journal of translational medicine	2025	The circRNA-mediated ceRNA molecular regulatory network in fatigue-type type 2 diabete.	hsa_circ_0044623				type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0044623 is down-regulated in F-T2DM in both sequencing and RT-qPCR validation. It is part of a down-regulated ceRNA axis (hsa_circ_0044623/hsa-mir-129-5p/MYLK3) linked to myocardial contractility efficiency and fatigue-related pathology in F-T2DM.	0.5922
40898233	Journal of translational medicine	2025	The circRNA-mediated ceRNA molecular regulatory network in fatigue-type type 2 diabete.	hsa_circ_0002622				type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0002622 is down-regulated in F-T2DM and forms a down-regulated ceRNA axis with hsa-mir-200b-3p and RAB21. Through RAB21-related functions, this axis is linked to glucose transport and mitochondrial energy metabolism disturbances that may contribute to fatigue symptoms."	0.5922
40900300	Clinical and experimental dental research	2025	"Hsa_circ_0005325 Regulates the Proliferation, Apoptosis, Colony Formation, Migration, and Angiogenesis-Promoting Behavior of Oral Squamous Cell Carcinoma Cells Through the miR-433-3p/HMGA2 Axis."	hsa_circ_0005325		hsa_circ_UBA2	UBA2	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"hsa_circ_0005325 is up-regulated in OSCC tumor tissues and OSCC cell lines and functions as an oncogenic circRNA. It promotes proliferation, colony formation, migration and angiogenesis while inhibiting apoptosis, mainly by sponging miR-433-3p to relieve repression of HMGA2."	0.705
40902508	International dental journal	2025	Initial Insights into the NET-Associated ceRNA Network in Pulpitis: Transcriptomic and Functional Exploration.		hsa_circDNAH11_003	hsa_circ_DNAH11	DNAH11	pulpitis	MONDO:0006937	pulpitis	up-regulated	RT-qPCR; RNA-seq	"hsa_circDNAH11_003 is up-regulated in inflamed human pulp tissue and is proposed to act in a NET-associated ceRNA axis by binding hsa-miR-877-5p to enhance C3 expression, contributing to inflammatory/immune responses in pulpitis."	0.4032
40902508	International dental journal	2025	Initial Insights into the NET-Associated ceRNA Network in Pulpitis: Transcriptomic and Functional Exploration.		hsa_circSLC15A4_001	hsa_circ_SLC15A4	SLC15A4	pulpitis	MONDO:0006937	pulpitis	down-regulated	RT-qPCR; RNA-seq	"hsa_circSLC15A4_001 is down-regulated in inflamed human pulp tissue by RT-qPCR. The paper places it in a predicted ceRNA axis with hsa-miR-30d-3p and H2AC14, linked to NET-associated inflammatory regulation in pulpitis."	0.4032
40902508	International dental journal	2025	Initial Insights into the NET-Associated ceRNA Network in Pulpitis: Transcriptomic and Functional Exploration.		hsa_circGABBR2_009	hsa_circ_GABBR2	GABBR2	pulpitis	MONDO:0006937	pulpitis	down-regulated	RT-qPCR; RNA-seq	"hsa_circGABBR2_009 is down-regulated in inflamed human pulp tissue by RT-qPCR. The study includes it in a predicted NET-associated ceRNA axis with hsa-miR-193b-3p and H4C11, implicating it in immune/inflammatory regulation during pulpitis."	0.4032
40910771	Microbiology spectrum	2025	HBV-encoded circRNA-5 promotes hepatocellular carcinoma progression by regulating the miR-9-3p/Hippo signaling axis.		HBV-circRNA-5 / circRNA-5	hbv_circ_HBV		hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"HBV-circRNA-5 is a virus-encoded circRNA detected in HBV-positive HCC tissues/cells and mainly localized in the cytoplasm. It promotes HCC proliferation and metastatic phenotypes and enhances tumor growth in vivo, largely by sponging miR-9-3p to increase YAP/TAZ and activate Hippo/YAP output."	0.7927
40911349	The Journal of general virology	2025	Conserved and distinct expression of circular RNAs in commercially used Marek's disease vaccine viruses.		circMeq		meq	Marek's disease / MD	MONDO:0016101	neurolymphomatosis	dysregulated	RNA-seq	"circMeq is a GaHV-2-derived circRNA from the meq locus that shows markedly reduced abundance in the avirulent vaccine strain CVI-988 compared with the virulent RB-1B strain, suggesting an association with virulence-related transcriptional/splicing differences."	0.2414
40911349	The Journal of general virology	2025	Conserved and distinct expression of circular RNAs in commercially used Marek's disease vaccine viruses.		circLATs		LATs	Marek's disease / MD	MONDO:0016101	neurolymphomatosis	unknown	RT-qPCR; RNA-seq	"circLATs are viral circRNAs produced from the LATs locus antisense to the ICP4 gene across GaHV-2 (CVI-988), GaHV-3, and MeHV-1. The study maps and validates their back-splice junctions and suggests they may contribute to conserved latency/viral-cycle functions via their antisense relationship to the ICP4 region."	0.4063
40911349	The Journal of general virology	2025	Conserved and distinct expression of circular RNAs in commercially used Marek's disease vaccine viruses.		circUL15s		UL15	Marek's disease / MD	MONDO:0016101	neurolymphomatosis	unknown	RT-qPCR; RNA-seq	"circUL15s are conserved viral circRNAs produced from the UL15 DNA-packaging terminase locus across GaHV-2 (CVI-988), GaHV-3, and MeHV-1, with a predominant circular transcript within UL15 exon 2. Their function is not resolved, but the paper proposes they may contribute to the viral cycle, potentially via interactions with neighboring transcripts or by encoding an alternative functional protein domain."	0.4063
40911349	The Journal of general virology	2025	Conserved and distinct expression of circular RNAs in commercially used Marek's disease vaccine viruses.		circLATs		LATs	Marek's disease / MD	MONDO:0016101	neurolymphomatosis	unknown	RT-qPCR; RNA-seq	"circLATs are viral circRNAs produced from the LATs locus antisense to the ICP4 gene across GaHV-2 (CVI-988), GaHV-3, and MeHV-1. The study maps and validates their back-splice junctions and suggests they may contribute to conserved latency/viral-cycle functions via their antisense relationship to the ICP4 region."	0.4063
40911349	The Journal of general virology	2025	Conserved and distinct expression of circular RNAs in commercially used Marek's disease vaccine viruses.		circUL15s		UL15	Marek's disease / MD	MONDO:0016101	neurolymphomatosis	unknown	RT-qPCR; RNA-seq	"circUL15s are conserved viral circRNAs produced from the UL15 DNA-packaging terminase locus across GaHV-2 (CVI-988), GaHV-3, and MeHV-1, with a predominant circular transcript within UL15 exon 2. Their function is not resolved, but the paper proposes they may contribute to the viral cycle, potentially via interactions with neighboring transcripts or by encoding an alternative functional protein domain."	0.4063
40911349	The Journal of general virology	2025	Conserved and distinct expression of circular RNAs in commercially used Marek's disease vaccine viruses.		circLATs		LATs	Marek's disease / MD	MONDO:0016101	neurolymphomatosis	unknown	RT-qPCR; RNA-seq	"circLATs are viral circRNAs produced from the LATs locus antisense to the ICP4 gene across GaHV-2 (CVI-988), GaHV-3, and MeHV-1. The study maps and validates their back-splice junctions and suggests they may contribute to conserved latency/viral-cycle functions via their antisense relationship to the ICP4 region."	0.4063
40911349	The Journal of general virology	2025	Conserved and distinct expression of circular RNAs in commercially used Marek's disease vaccine viruses.		circUL15s		UL15	Marek's disease / MD	MONDO:0016101	neurolymphomatosis	unknown	RT-qPCR; RNA-seq	"circUL15s are conserved viral circRNAs produced from the UL15 DNA-packaging terminase locus across GaHV-2 (CVI-988), GaHV-3, and MeHV-1, with a predominant circular transcript within UL15 exon 2. Their function is not resolved, but the paper proposes they may contribute to the viral cycle, potentially via interactions with neighboring transcripts or by encoding an alternative functional protein domain."	0.4063
40918144	Frontiers in immunology	2025	"Circular RNA hsa_Circ_0007552 inhibits lung adenocarcinoma proliferation, migration and invasion via the miR-7974/BAP1 axis."	hsa_circ_0007552	Circ_RILPL1	hsa_circ_RILPL1	RILPL1	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; RNA-seq	"Circ_0007552 (Circ_RILPL1) is down-regulated in LUAD tissues/cells and functions as a tumor suppressor. It mainly acts via a ceRNA mechanism by sponging miR-7974, thereby relieving repression of BAP1 and inhibiting LUAD proliferation, migration, invasion, tumor growth and bone metastasis; low Circ_0007552 is associated with worse patient survival."	0.84
40918151	"Open medicine (Warsaw, Poland)"	2025	CircASH1L-mediated tumor progression in triple-negative breast cancer: PI3K/AKT pathway mechanisms.	hsa_circ_0003247	circASH1L / circASH1L-1	hsa_circ_ASH1L	ASH1L	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	Microarray	"circASH1L (hsa_circ_0003247) is up-regulated in TNBC clinical samples (GSE113230) and promotes TNBC xenograft tumor growth. Manipulating circASH1L levels alters Ki67 proliferation and PI3K/AKT pathway marker proteins, supporting a tumor-promoting role via PI3K/AKT activation."	0.5546
40925894	Cell death & disease	2025	CircPSD3 aggravates tumor progression by maintaining TCA cycle and mitochondrial function via regulating SUCLG2 in thyroid carcinoma.	hsa_circ_0004458	circPSD3	hsa_circ_PSD3	PSD3	thyroid cancer / TC	MONDO:0002108	thyroid cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circPSD3 is upregulated in thyroid carcinoma/PTC and correlates with tumor size and lymph node metastasis. It promotes tumor cell proliferation and suppresses mitochondria-mediated apoptosis by sponging miR-338-5p to upregulate SUCLG2, sustaining the TCA cycle and mitochondrial respiration."	0.853
40931215	"Cancer immunology, immunotherapy : CII"	2025	Circ_0074158 and QKI6: A regulatory axis for PD-L1 ubiquitination and immune evasion in NSCLC.	hsa_circ_0074158	circ_0074158	hsa_circ_CTNNA1	CTNNA1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	unknown	RT-qPCR; RNA-seq	"In NSCLC models, hsa_circ_0074158 binds the RBP QKI6 and increases PD-L1 ubiquitination, lowering PD-L1 protein and reducing immune evasion. Functionally, circ_0074158 suppresses proliferation/invasion/migration and enhances CD8+ T-cell activity, promoting tumour cell apoptosis and inhibiting tumour growth."	0.7878
40931215	"Cancer immunology, immunotherapy : CII"	2025	Circ_0074158 and QKI6: A regulatory axis for PD-L1 ubiquitination and immune evasion in NSCLC.	mmu_circ_0000860				non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	unknown	RT-qPCR	"In a mouse syngeneic tumour model using LLC cells, overexpression of mmu_circ_0000860 suppresses tumour growth and increases CD8 staining in tumours. Tumour protein changes (higher QKI6/STUB1 and lower PD-L1/OTUB1) align with reduced immune evasion via PD-L1 downregulation."	0.5358
40936698	Frontiers in oncology	2025	Trajectories and influencing factors of psychological distress in nasopharyngeal carcinoma patients receiving radiotherapy (incorporating genetic factors): a multicenter longitudinal study.	hsa_circ_0004277				psychological distress	MONDO:0005084	mental disorder	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0004277 is higher in the rise-distress trajectory than in the decline-distress trajectory in NPC patients during radiotherapy (blood/ PBMC samples). The study proposes a ceRNA mechanism involving hsa-miR-24-3p or hsa-miR-92b-3p regulating BRCA1, potentially contributing to PD-related pathophysiology."	0.4032
40940312	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2025	Lactate Metabolic Reprogramming Mediated by CircRNA-LDHA Complex Facilitates Innate Immune Evasion of Liver Cancer.	hsa_circ_0092297	circSMPD4	hsa_circ_SMPD4	SMPD4	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circSMPD4 is upregulated in HCC and promotes Warburg-like lactate production, leading to reduced NK-cell cytotoxicity and enhanced immune evasion, tumor growth, and metastasis. It binds LDHA and scaffolds SIRT2 to deacetylate LDHA, blocking LDHA_HSC70 engagement and CMA-lysosomal degradation, thereby stabilizing LDHA and increasing lactate export."	0.8893
40950872	Journal of thoracic disease	2025	Circular RNA circFTO promotes pressure overload-induced cardiac hypertrophy by encoding a novel protein FTO-36aa.	mmu_circ_0001717	circFTO	mmu_circ_FTO	FTO	cardiac hypertrophy	MONDO:0005045	hypertrophic cardiomyopathy	up-regulated	RT-qPCR; Microarray	"In TAC/PE-induced cardiac hypertrophy models, circFTO (mmu_circ_0001717) is up-regulated and promotes cardiomyocyte hypertrophy and fibrosis. Mechanistically, circFTO is translated (IRES-dependent) to generate FTO-36aa, which accelerates ubiquitination-proteasome degradation of FTO, increases global m6A levels, and enables IGF2BP2 to stabilize m6A-methylated hypertrophic transcripts."	0.7435
40950914	Journal of thoracic disease	2025	Identify malignant pulmonary nodules-associated circRNAs and develop a prediction model to estimate the probability of malignancy in pulmonary nodules.		hsa_circCFLAR_008	hsa_circ_CFLAR	CFLAR	malignant pulmonary nodules	MONDO:0021117	lung neoplasm	up-regulated	RT-qPCR; RNA-seq	Serum hsa_circCFLAR_008 is up-regulated in malignant versus benign pulmonary nodules and was the only qPCR-validated circRNA showing a significant difference. Incorporating its expression into a multivariate model improved discrimination of malignant PNs in a Chinese cohort.	0.5047
40951426	Frontiers in endocrinology	2025	Differential expression and correlation analysis of whole transcriptome for type 2 diabetes mellitus.	hsa_circ_0011556				type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RNA-seq	"hsa_circ_0011556 is down-regulated in whole blood from T2DM patients and is included as one of six key circRNAs in a predicted circRNA-miRNA-mRNA ceRNA network, pairing with hsa-miR-24-3p. Its downstream mRNA targets and functional effects were not experimentally validated in this study."	0.1768
40951426	Frontiers in endocrinology	2025	Differential expression and correlation analysis of whole transcriptome for type 2 diabetes mellitus.	hsa_circ_0019606				type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RNA-seq	"hsa_circ_0019606 is down-regulated in whole blood from T2DM patients and is included as a key circRNA in the predicted ceRNA network, pairing with hsa-miR-4742-3p. No targeted experimental validation of this axis was reported."	0.1768
40951426	Frontiers in endocrinology	2025	Differential expression and correlation analysis of whole transcriptome for type 2 diabetes mellitus.	hsa_circ_0014829				type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RNA-seq	"hsa_circ_0014829 is up-regulated in whole blood from T2DM patients and was selected into a predicted ceRNA network, pairing with Novel_404. The study does not provide experimental validation beyond sequencing and computational network construction."	0.1768
40951426	Frontiers in endocrinology	2025	Differential expression and correlation analysis of whole transcriptome for type 2 diabetes mellitus.	hsa_circ_0017434				type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RNA-seq	hsa_circ_0017434 is down-regulated in whole blood from T2DM patients and was included as a key circRNA in a predicted ceRNA network via pairing with hsa-miR-576-5p. No downstream mRNA targets were specified for this circRNA in the provided text.	0.1768
40951426	Frontiers in endocrinology	2025	Differential expression and correlation analysis of whole transcriptome for type 2 diabetes mellitus.	hsa_circ_0001793				type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RNA-seq	hsa_circ_0001793 is up-regulated in whole blood from T2DM patients and is included in a predicted ceRNA network via pairing with hsa-miR-652-5p. The study provides sequencing-based differential expression and network construction but no wet-lab validation for this circRNA.	0.1768
40951426	Frontiers in endocrinology	2025	Differential expression and correlation analysis of whole transcriptome for type 2 diabetes mellitus.	hsa_circ_0019370				type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RNA-seq	hsa_circ_0019370 is up-regulated in whole blood from T2DM patients and was incorporated into a predicted circRNA-miRNA-mRNA ceRNA network via interaction with hsa-miR-340-5p. The work is sequencing- and bioinformatics-based without experimental functional validation for this circRNA.	0.1768
40956561	Translational stroke research	2025	CircRNA circ_0004058 Modulates Early Brain Injury in Subarachnoid Hemorrhage Through miR-221-3p and VE1 Activation Pathway.	rno_circ_0004058	circ_0004058			subarachnoid hemorrhage / SAH	MONDO:0005099	subarachnoid hemorrhage	down-regulated	RT-qPCR; Microarray	"In a rat SAH model, circ_0004058 is down-regulated in brain/hippocampal tissues. circ_0004058 acts as a ceRNA to sponge miR-221-3p, thereby relieving miR-221-3p-mediated suppression of LYVE1, which increases LYVE1-related macrophage/angiogenesis signals (e.g., VEGF-A) and alleviates early brain injury."	0.8058
40959103	Journal of Cancer	2025	Whole-transcriptome analysis reveals the interactions of mRNAs and ncRNAs to predict and validate ceRNA networks in osteosarcoma with lung metastases.	hsa_circ_0012586 	circ_0012586			osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; RNA-seq	"circ_0012586 is up-regulated in highly metastatic osteosarcoma cells/tissues and lung-metastatic lesions. It promotes osteosarcoma cell viability, migration, and invasion by acting as a ceRNA that sponges miR-200b-5p to increase MFAP5 expression, contributing to osteosarcoma lung metastasis."	0.6777
40963905	Theranostics	2025	RBMS1-mediates the biogenesis of circNFIB promotes perineural invasion of pancreatic ductal adenocarcinoma via the L1CAM/MAPK pathway.	hsa_circ_0086376	circNFIB	hsa_circ_NFIB	NFIB	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circNFIB (hsa_circ_0086376) is upregulated in PDAC, especially in samples with high perineural invasion, and high circNFIB indicates poor prognosis. Functionally, circNFIB promotes PDAC perineural invasion in vitro and in vivo. Mechanistically, circNFIB binds the RBP IGF2BP3 to stabilize L1CAM mRNA and activate the ERK/MAPK pathway, while RBMS1 promotes circNFIB biogenesis by binding NFIB pre-mRNA introns."	0.8974
40966379	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2025	CircPVT1 Promotes Lung Metastasis and Tumor Progression in Renal Cell Carcinoma by Encoding the cP104aa Peptide and Targeting EIF4A3.	hsa_circ_0001821	CircPVT1	hsa_circ_PVT1	PVT1	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR	"circPVT1 is up-regulated in RCC and associated with poor prognosis. It promotes RCC proliferation, invasion/migration, EMT and lung metastasis. Mechanistically, circPVT1 binds EIF4A3 to increase c-MYC expression and also contributes via encoding cP104aa."	0.8913
40968149	NPJ precision oncology	2025	Diagnostic and prognostic roles of circulating EVs circ_PPAPDC1A in ICIs resistance in NSCLC.		circ_PPAPDC1A / hsa_circ_100696	hsa_circ_PPAPDC1A	PPAPDC1A	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circ_PPAPDC1A is upregulated in NSCLC with acquired ICIs resistance and is enriched in circulating extracellular vesicles. Functionally, it decreases anti-PD-1 efficacy by promoting malignant phenotypes (proliferation, clonogenesis, invasion/migration) and inhibiting apoptosis, and in vivo it induces an immunosuppressive state with CD8+ T-cell exhaustion. Clinically, EV circ_PPAPDC1A shows strong diagnostic performance for ICIs resistance and high expression predicts shorter PFS."	0.7074
40968748	Journal of gynecologic oncology	2026	Enhancement of circular RNA 0002577 in serum exosomes in patients with endometrial cancer accelerates disease progression via general transcription factor II-I repeat domain-containing 1 (GTF2IRD1).	hsa_circ_0002577	circRNA 0002577 / circ_0002577			Uterine corpus endometrial carcinoma / UCEC	MONDO:0000553	uterine corpus endometrial carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0002577 is significantly up-regulated in serum-derived exosomes from UCEC patients and promotes UCEC cell proliferation and migration. The study identifies GTF2IRD1 as a key downstream effector correlated with circ_0002577, forming an exosome-mediated circ_0002577_GTF2IRD1 axis that accelerates tumor progression."	0.657
40983631	Cell death and differentiation	2026	Induction of ferroptosis in prostate cancer by CCDC719-13 via TRIM21-mediated ubiquitination of SLC7A11.		CCDC719-13 / CCDC7_____	hsa_circ_CCDC7	CCDC7	prostate cancer / PCa	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; ISH; RNA-seq	"CCDC719-13 is down-regulated in advanced/recurrent prostate cancer and serves as an independent prognostic marker. Its tumor-suppressive activity is mainly mediated by its encoded protein CCDC7241aa, which promotes TRIM21-dependent ubiquitination and degradation of SLC7A11, inducing ferroptosis and reducing tumor growth; recombinant CCDC7241aa also enhances docetaxel/enzalutamide efficacy in vitro."	0.8793
40990002	Non-coding RNA research	2025	NSUN2-mediated m5C hypermethylation of hsa_circ_0004516 promotes breast cancer brain metastasis by activating AKT signaling.	hsa_circ_0004516				breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0004516 is upregulated in breast cancer brain metastasis and promotes 231-BR cell proliferation, migration, and invasion by activating AKT signaling. NSUN2-dependent m5C methylation increases its stability, with YBX1 binding as an m5C reader, and a ceRNA relationship is supported via miR-1301-3p targeting AKT1."	0.7968
40990491	Cancer science	2025	N6-Methyladenosine-Modified circNEK11 Promotes Hepatocellular Carcinoma Progression via the miR-1236-3p/GPX2 Axis.	hsa_circ_0067347	circNEK11	hsa_circ_NEK11	NEK11	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circNEK11 (hsa_circ_0067347), derived from NEK11 exons 12_15, is up-regulated in HCC (especially recurrent tissues) and promotes malignant phenotypes and tumor growth/metastasis. It acts as a cytoplasmic ceRNA by sponging miR-1236-3p to increase GPX2, and its m6A-dependent nuclear export is facilitated by the reader YTHDC1."	0.8621
40997603	"Clinics (Sao Paulo, Brazil)"	2025	CircRNA MALAT1/miR-96-5p/FOXK2 axis regulates choroidal neovascularization.		circRNA MALAT1 / circ-MALAT1	hsa_circ_MALAT1	MALAT1	Choroidal Neovascularization / CNV	MONDO:0810000	choroidal neovascularization	up-regulated	RT-qPCR	"In CNV/nAMD models, circ-MALAT1 is up-regulated and promotes pathological angiogenesis. It functions as a ceRNA that sponges miR-96_5p to increase FOXK2, thereby enhancing endothelial cell viability/proliferation, migration and tube formation and reducing apoptosis. circ-MALAT1 is also elevated in aqueous humor from nAMD patients, supporting potential translational relevance."	0.8149
40997603	"Clinics (Sao Paulo, Brazil)"	2025	CircRNA MALAT1/miR-96-5p/FOXK2 axis regulates choroidal neovascularization.	mmu_circ_0007962	"circ-0007,962"	mmu_circ_MALAT1	MALAT1	Choroidal Neovascularization / CNV	MONDO:0810000	choroidal neovascularization	up-regulated	RT-qPCR	"In a laser-induced CNV mouse model, circ-0007,962 is up-regulated in RPE/choroid and its knockdown reduces CNV-associated choroidal lesion pathology and fluorescein leakage. The study uses circ-0007,962 as the mouse homolog readout corresponding to circ-MALAT1 in the in vivo CNV experiments."	0.3957
40999364	BMC genomics	2025	"Integrative assessment of RNA sequencing and in silico analysis to pinpoint mRNAs, lncRNAs, and circRNAs interactions with miRNAs underlying arsenic-induced neurotoxicity."	hsa_circ_0005465	circCLIP1	hsa_circ_CLIP1	CLIP1	arsenic-induced neurotoxicity / arsenic-induced neuronal toxicity	MONDO:0005527	toxic encephalopathy	up-regulated	RNA-seq	circCLIP1 is up-regulated in arsenic-exposed differentiated SH-SY5Y cells and was included in a miRNet-derived circRNA_miRNA interaction network related to arsenic-induced neurotoxicity; no functional validation was performed.	0.1768
40999364	BMC genomics	2025	"Integrative assessment of RNA sequencing and in silico analysis to pinpoint mRNAs, lncRNAs, and circRNAs interactions with miRNAs underlying arsenic-induced neurotoxicity."	hsa_circ_0013218	circDNTTIP2	hsa_circ_DNTTIP2	DNTTIP2	arsenic-induced neurotoxicity / arsenic-induced neuronal toxicity	MONDO:0005527	toxic encephalopathy	up-regulated	RNA-seq	"circDNTTIP2 is up-regulated after arsenic exposure in differentiated SH-SY5Y cells and was included in predicted circRNA_miRNA interaction networks relevant to arsenic-induced neurotoxicity, without experimental functional validation."	0.1768
40999364	BMC genomics	2025	"Integrative assessment of RNA sequencing and in silico analysis to pinpoint mRNAs, lncRNAs, and circRNAs interactions with miRNAs underlying arsenic-induced neurotoxicity."	hsa_circ_0006470	circMFN2	hsa_circ_MFN2	MFN2	arsenic-induced neurotoxicity / arsenic-induced neuronal toxicity	MONDO:0005527	toxic encephalopathy	up-regulated	RNA-seq	"circMFN2 is up-regulated in arsenic-treated differentiated SH-SY5Y cells; it is part of predicted circRNA_miRNA regulatory networks and was discussed in relation to autophagy, but no direct mechanistic validation in neurotoxicity was performed."	0.1768
40999364	BMC genomics	2025	"Integrative assessment of RNA sequencing and in silico analysis to pinpoint mRNAs, lncRNAs, and circRNAs interactions with miRNAs underlying arsenic-induced neurotoxicity."	hsa_circ_0004289	circKHDRBS1	hsa_circ_KHDRBS1	KHDRBS1	arsenic-induced neurotoxicity / arsenic-induced neuronal toxicity	MONDO:0005527	toxic encephalopathy	up-regulated	RNA-seq	circKHDRBS1 is up-regulated in arsenic-exposed differentiated SH-SY5Y cells and was included in bioinformatics-predicted circRNA_miRNA networks linked to neurotoxicity; no mechanistic validation was conducted.	0.1768
40999364	BMC genomics	2025	"Integrative assessment of RNA sequencing and in silico analysis to pinpoint mRNAs, lncRNAs, and circRNAs interactions with miRNAs underlying arsenic-induced neurotoxicity."	hsa_circ_0001222	circFBXO7	hsa_circ_FBXO7	FBXO7	arsenic-induced neurotoxicity / arsenic-induced neuronal toxicity	MONDO:0005527	toxic encephalopathy	up-regulated	RNA-seq	circFBXO7 is up-regulated in arsenic-exposed differentiated SH-SY5Y cells and appears in predicted circRNA_miRNA networks; discussion links it to Wnt/beta-catenin signaling in other contexts but no mechanistic validation was performed here.	0.1768
40999364	BMC genomics	2025	"Integrative assessment of RNA sequencing and in silico analysis to pinpoint mRNAs, lncRNAs, and circRNAs interactions with miRNAs underlying arsenic-induced neurotoxicity."	hsa_circ_0000236	circCSGALNACT2	hsa_circ_CSGALNACT2	CSGALNACT2	arsenic-induced neurotoxicity / arsenic-induced neuronal toxicity	MONDO:0005527	toxic encephalopathy	down-regulated	RNA-seq	circCSGALNACT2 is down-regulated in arsenic-exposed differentiated SH-SY5Y cells and was incorporated into predicted circRNA_miRNA interaction networks relevant to neurotoxicity; no functional validation was performed.	0.1768
40999364	BMC genomics	2025	"Integrative assessment of RNA sequencing and in silico analysis to pinpoint mRNAs, lncRNAs, and circRNAs interactions with miRNAs underlying arsenic-induced neurotoxicity."	hsa_circ_0001290	circSETD2	hsa_circ_SETD2	SETD2	arsenic-induced neurotoxicity / arsenic-induced neuronal toxicity	MONDO:0005527	toxic encephalopathy	down-regulated	RNA-seq	circSETD2 is down-regulated by arsenic exposure in differentiated SH-SY5Y cells and appears in predicted circRNA_miRNA networks relevant to arsenic-induced neurotoxicity; mechanistic validation was not performed.	0.1768
40999364	BMC genomics	2025	"Integrative assessment of RNA sequencing and in silico analysis to pinpoint mRNAs, lncRNAs, and circRNAs interactions with miRNAs underlying arsenic-induced neurotoxicity."	hsa_circ_0008128	circNPU54	hsa_circ_NUP54	NUP54	arsenic-induced neurotoxicity / arsenic-induced neuronal toxicity	MONDO:0005527	toxic encephalopathy	down-regulated	RNA-seq	circNUP54 is down-regulated in arsenic-exposed differentiated SH-SY5Y cells and was included in predicted circRNA_miRNA interaction networks related to neurotoxicity; no experimental validation was performed.	0.1768
40999364	BMC genomics	2025	"Integrative assessment of RNA sequencing and in silico analysis to pinpoint mRNAs, lncRNAs, and circRNAs interactions with miRNAs underlying arsenic-induced neurotoxicity."	hsa_circ_0006531	circRBM6	hsa_circ_RBM6	RBM6	arsenic-induced neurotoxicity / arsenic-induced neuronal toxicity	MONDO:0005527	toxic encephalopathy	down-regulated	RNA-seq	"circRBM6 is down-regulated after arsenic exposure in differentiated SH-SY5Y cells and was included in predicted circRNA_miRNA interaction networks relevant to neurotoxicity, without experimental validation."	0.1768
40999364	BMC genomics	2025	"Integrative assessment of RNA sequencing and in silico analysis to pinpoint mRNAs, lncRNAs, and circRNAs interactions with miRNAs underlying arsenic-induced neurotoxicity."	hsa_circ_0016733	circCDC42BPA	hsa_circ_CDC42BPA	CDC42BPA	arsenic-induced neurotoxicity / arsenic-induced neuronal toxicity	MONDO:0005527	toxic encephalopathy	down-regulated	RNA-seq	circCDC42BPA is down-regulated following arsenic exposure in differentiated SH-SY5Y cells and was included in predicted circRNA_miRNA interaction networks relevant to neurotoxicity; no experimental validation was performed.	0.1768
41006753	Communications biology	2025	IL6ST participates in the development of adolescent idiopathic scoliosis by regulating bone marrow mesenchymal stem cells.		CircSCAF8	hsa_circ_SCAF8	SCAF8	Adolescent idiopathic scoliosis / AIS	MONDO:0005488	adolescent idiopathic scoliosis	dysregulated	RT-qPCR; RNA-seq	"In AIS patient-derived BMSCs, circSCAF8 is identified as a dysregulated circRNA and an upstream regulator of IL6ST. circSCAF8 is mainly cytoplasmic; its knockdown reduces IL6ST expression, decreases BMSC proliferation, and inhibits osteogenic differentiation."	0.5229
41010991	"Medicina (Kaunas, Lithuania)"	2025	Curcumin as an Epigenetic Modulator: Suppression of Breast Cancer via the Hsa_circ_0001946/MiR-7-5p/Target Gene Axis.	hsa_circ_0001946	CDR1as / circ_0001946	hsa_circ_CDR1	CDR1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"hsa_circ_0001946 (CDR1as/ciRS-7) is upregulated in breast cancer tissues and cell lines and functions as a sponge for miR-7-5p to support oncogenic target gene expression (e.g., CKS2). Curcumin suppresses breast cancer cell proliferation and migration and promotes apoptosis partly by downregulating hsa_circ_0001946 and restoring miR-7-5p, thereby reducing downstream oncogenic targets."	0.5732
41013290	BMC gastroenterology	2025	Elevated CircYthdc2 expression is correlated with aggressive features and poor progression-free survival in hepatocellular carcinoma.		CircYTHDC2	hsa_circ_YTHDC2	YTHDC2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"CircYTHDC2 is up-regulated in LIHC tissues, patient serum, and LIHC cell lines and shows diagnostic value by ROC analysis. High CircYTHDC2 correlates with aggressive clinicopathological features and shorter progression-free survival. Mechanistically, YTHDC2 binds CircYTHDC2 and increases its stability through an m6A-dependent process."	0.7875
41017455	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2025	Extracellular Vesicle-Packaged circTAX1BP1 from Cancer-Associated Fibroblasts Regulates RNA m6A Modification through Lactylation of VIRMA in Colorectal Cancer Cells.	hsa_circ_0134036	circTAX1BP1	hsa_circ_TAX1BP1	TAX1BP1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"CAF/ITGA11+ myCAF-derived EV circTAX1BP1 is up-regulated in CRC/CRLM and promotes tumor growth and liver metastasis. It acts mainly by binding VIRMA and recruiting AARS2 to enhance VIRMA K1713 lactylation, which increases VIRMA-dependent m6A modification and stability of SP1 mRNA, activating SP1¡úTGF-beta transcription, TGF-beta/SMAD signaling, and EMT, forming a positive feedback loop in the TME. Clinically, high circTAX1BP1 indicates poor OS/DFS and plasma EV circTAX1BP1 shows diagnostic potential."	0.8988
41020260	Biomedical reports	2025	Hsa_circ_0122913 suppresses the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells and is involved in the effects of icariin treatment via sponging miR-501-5p.	hsa_circ_0122913	circ_0122913	hsa_circ_DCUN1D1	DCUN1D1	Osteoporosis / OP	MONDO:0005298	osteoporosis	up-regulated	RT-qPCR	"In human BMSCs, hsa_circ_0122913 inhibits cell viability/proliferation and osteogenic differentiation and increases apoptosis. Mechanistically, it sponges miR-501-5p and is linked to a regulatory relationship with its host gene DCUN1D1, contributing to icariin-associated effects on BMSCs and suggesting biomarker potential for osteoporosis risk."	0.5607
41020579	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2025	"Hsa_circRNA_0101125 Promotes Proliferation, Migration, and Invasion of Esophageal Squamous Cell Carcinoma via miR-143-3p/ZNF148 Axis."	hsa_circ_0101125	hsa_circRNA_0101125			Esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_0101125 functions as an oncogenic circRNA in ESCC cells, promoting proliferation, migration, and invasion. Mechanistically, it sponges miR-143-3p to relieve repression of ZNF148, accompanied by EMT marker changes (E-cadherin up, Vimentin down upon circRNA knockdown)."	0.5871
41021164	Discover oncology	2025	DNMT3A-R882 mutation promotes acute myeloid leukemia progression by recruiting E2H2 to inhibit circKCNQ5 methylation.	hsa_circ_0004136	circKCNQ5 / circ_0004136	hsa_circ_KCNQ5	KCNQ5	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"circKCNQ5 (hsa_circ_0004136) is up-regulated in DNMT3A-R882-mutant AML cell models. circKCNQ5 promotes AML cell proliferation, cell-cycle progression and tumor xenograft growth while inhibiting apoptosis. Mechanistically, DNMT3A-R882 mutation increases circKCNQ5 transcription by reducing promoter methylation, whereas EZH2 helps WT-DNMT3A enhance circKCNQ5 methylation and suppress its expression."	0.627
41022764	Nature communications	2025	"Direct circMAN1A2(2,3,4,5)-CENPB mRNA interaction regulates cell proliferation and cancer progression."		"circMAN1A2(2,3,4,5)"	hsa_circ_MAN1A2	MAN1A2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Northern Blot; RNA-seq	"circMAN1A2(2,3,4,5) is up-regulated in colorectal/colon cancer and promotes cancer cell proliferation and tumor growth. It directly base-pairs with the CENPB 3¡äUTR via its BSJ, enhancing IGF2BP2 binding and stabilizing CENPB mRNA, thereby supporting chromosome stability and CRC progression. LNA targeting the BSJ suppresses CRC progression in xenograft models."	0.8192
41023132	Experimental & molecular medicine	2025	CircCNOT6L modulates alternative splicing of SLC7A11 via splicing factor SRSF2 to confer ferroptosis resistance and promote metastasis in prostate cancer.	hsa_circ_0006168	circCNOT6L / circ_0006168	hsa_circ_CNOT6L	CNOT6L	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; RNA-seq	"circCNOT6L is up-regulated in prostate cancer, especially in metastatic settings, and promotes proliferation, EMT-associated migration/invasion, and metastasis. It functions mainly in the cytoplasm as a ceRNA that sponges miR-143-5p to upregulate SRSF2, which enhances SLC7A11 splicing/expression to suppress ferroptosis, contributing to malignant progression; EIF4A3 facilitates its biogenesis."	0.8446
41023807	BMC gastroenterology	2025	Circular RNA profiling and functional analysis implicate circ-ANKRD36C as a potential prognostic biomarker in gastric cancer.		circ-ANKRD36C / hsa_circRNA_405929	hsa_circ_ANKRD36C	ANKRD36C	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circ-ANKRD36C is up-regulated in gastric cancer tissues and promotes GC cell proliferation, migration, and invasion in vitro. It directly binds miR-15a-5p and is consistent with a ceRNA-like mechanism affecting miR-15a-5p targets (e.g., BMI1 and CCND1). High circ-ANKRD36C expression predicts poorer overall survival and serves as an independent prognostic biomarker."	0.8323
41035422	Molecular therapy. Oncology	2025	CircSPINT2 confers sensitivity to osimertinib via hsa-miR-1296-3p/RBP1 axis and inhibits NSCLC progression.	hsa_circ_0050818	circSPINT2	hsa_circ_SPINT2	SPINT2	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; RNA-seq	circSPINT2 (hsa_circ_0050818) is down-regulated in osimertinib-resistant LUAD/NSCLC models. It acts as a tumor-suppressive circRNA that increases osimertinib sensitivity by promoting drug-induced apoptosis via a ceRNA mechanism (sponging hsa-miR-1296-3p to upregulate RBP1). Secreted circSPINT2 is proposed as a potential monitoring biomarker for osimertinib resistance.	0.8204
41037159	Brain informatics	2025	Regulation of tau protein by circCwc27: shared pathogenic mechanisms in type 2 diabetes mellitus and Alzheimer's disease.		circCwc27 / Circular RNA Cwc27	hsa_circ_CWC27	Cwc27	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	unknown	RT-qPCR	"This study identifies circCwc27 (from host gene Cwc27) as a molecule linking AD and T2DM. circCwc27 overexpression increases Tau protein/phospho-Tau and enhances Tau seeding/aggregation, while reducing intracellular glycogen storage, implying combined neurodegenerative and metabolic effects that are independent of Akt-GSK3beta and APP changes."	0.5218
41039575	Molecular cancer	2025	Hsa_circ_0038737 promotes PARPi resistance in castration-resistant prostate cancer via IGF2BP3-mediated DNPH1 mRNA stabilization.	hsa_circ_0038737		hsa_circ_GTF3C1	GTF3C1	castration-resistant prostate cancer / CRPC	MONDO:0850353	castration-resistant prostate carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0038737 is up-regulated and nucleus-enriched in prostate cancer/CRPC, where it promotes proliferation and PARP inhibitor resistance. It acts as an RBP scaffold by binding IGF2BP3 to stabilize DNPH1 mRNA, enhancing DNA damage repair and thereby reducing PARPi efficacy."	0.8707
41041073	Theranostics	2025	Hsa_circ_0058495-mediated IGF2BP2 ubiquitination and m6A modification of MEKK1 promote the progression of PDAC.	hsa_circ_0058495	circRHBDD1	hsa_circ_RHBDD1	RHBDD1	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; ISH; RNA-seq; Microarray	"hsa_circ_0058495 is upregulated in PDAC tissues, serum, and PDAC-derived exosomes and promotes malignant phenotypes. It binds and stabilizes IGF2BP2 by inhibiting TRIM25-mediated ubiquitination and suppressing autophagy-lysosome degradation, thereby enhancing m6A-dependent MEKK1 mRNA stability and activating ERK1/2 signaling. Exosomal transfer of hsa_circ_0058495 also promotes M2 macrophage polarization to support an immunosuppressive tumor microenvironment and is associated with poor overall survival."	0.8989
41041848	Molecular medicine reports	2025	Circular RNA hsa_circ_0000118 promotes atrial fibrosis by regulating the microRNA_34a_5p/Smad4 axis.	hsa_circ_0000118		hsa_circ_MAN1A2	MAN1A2	atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	up-regulated	RT-qPCR; RNA-seq	"In atrial fibrillation, hsa_circ_0000118 is upregulated in atrial tissue and higher plasma levels predict worse prognosis. Functionally, it promotes atrial fibrosis/structural remodeling by enhancing cardiac fibroblast migration and collagen I/III production via a ceRNA mechanism involving miR-34a-5p and Smad4."	0.8198
41044609	Molecular cancer	2025	A circRNA promotes esophageal squamous cell carcinoma progression by inhibiting TRIM25-mediated degradation of IGF2BP family members.		circLNF	hsa_circ_FIRRE	FIRRE	Esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circLNF is significantly upregulated in ESCC and functions as an oncogenic circRNA that promotes proliferation, migration/invasion, tumor growth and lung metastasis. It binds IGF2BP1/2/3 via ¡°CAUC¡± motifs and stabilizes these proteins by blocking TRIM25-mediated ubiquitination and proteasomal degradation, and high circLNF predicts worse overall survival."	0.8932
41044672	Hereditas	2025	CircRNA-14052 promotes breast cancer progression via miR-214-3p/IKBKB pathway.		"circRNA-14,052 / circRNA-14052"			breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circRNA-14,052 is up-regulated in breast cancer tissues and acts as an oncogenic circRNA. It sponges miR-214-3p to de-repress IKBKB, promoting IL-6/JAK2/STAT3 signaling and enhancing malignant phenotypes and xenograft growth."	0.6545
41046253	Gut pathogens	2025	Salmonella typhimurium downregulates circHIPK2 expression via CeRNA mechanism to inhibit cell migration and tumorigenesis.	hsa_circ_0001756	circHIPK2 / Circular HIPK2	hsa_circ_HIPK2	HIPK2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"In S. typhimurium-infected CRC models, circHIPK2 (hsa_circ_0001756, from HIPK2) is down-regulated and functions as a ceRNA by sponging miR-124-3p. Reducing circHIPK2 suppresses migration, cytokine induction, and tumor growth, while circHIPK2 overexpression promotes proliferation/migration and increases tumor burden in a syngeneic mouse model."	0.8324
41048388	PeerJ	2025	Study on the diagnostic potential and molecular mechanism of hsa_circ_0000831 in oral squamous cell carcinoma.	hsa_circ_0000831		hsa_circ_CEP192	CEP192	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000831 (from CEP192) is upregulated in OSCC tissues and shows diagnostic potential by ROC analysis. Functionally, its knockdown suppresses OSCC cell viability/migration/invasion and increases apoptosis, while a ceRNA network with five predicted miRNAs is proposed but not experimentally validated."	0.6758
41049614	"Research (Washington, D.C.)"	2025	A Circular RNA Promotes Tumor Metastasis through Stabilizing MSI2 Protein in Pancreatic Ductal Adenocarcinoma.	hsa_circ_0000992	circPRKD3	hsa_circ_PRKD3	PRKD3	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circPRKD3 (hsa_circ_0000992), derived from PRKD3 exon 2, is up-regulated in PDAC tumors and patient serum and predominantly localizes to the cytoplasm. It promotes PDAC migration/invasion and metastasis by binding the RBP MSI2 and stabilizing MSI2 protein via inhibiting beta-TRCP-mediated ubiquitination and proteasomal degradation, and it shows prognostic (worse OS with high expression) and liquid-biopsy diagnostic potential."	0.897
41050095	Materials today. Bio	2025	pH-responsive 2D niobium carbide nanosheets for targeted circPUM1 siRNA delivery in ovarian cancer therapy.	hsa_circ_0000043	circPUM1	hsa_circ_PUM1	PUM1	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circPUM1 is up-regulated in ovarian cancer and is associated with higher microvessel density. It is packaged into exosomes and transferred to endothelial cells to promote angiogenesis by sponging miR-607 and upregulating VEGFA and RAB27B, enhancing VEGF signaling and exosome release. Silencing circPUM1 with siRNA delivered by pH-responsive MXene nanosheets inhibits angiogenesis and peritoneal dissemination in vitro and in vivo."	0.8007
41057949	Journal of experimental & clinical cancer research : CR	2025	Cancer-associated fibroblast-derived circKLHL24 drives perineural invasion in pancreatic cancer via dual regulation of the sec31a-CXCL12 axis.	hsa_circ_0001369	circKLHL24	hsa_circ_KLHL24	KLHL24	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"In PDAC, CAF-enriched circKLHL24 is up-regulated and promotes perineural invasion by increasing CXCL12 expression and secretion. It binds Sec31A to prevent ubiquitin-mediated degradation (enhancing CXCL12 trafficking/secretion) and sponges miR-615-5p to relieve repression of CXCL12 mRNA. High circKLHL24 is associated with severe PNI and poor survival, suggesting therapeutic potential in targeting the circKLHL24/Sec31A/miR-615-5p/CXCL12 axis."	0.9032
41058681	Frontiers in immunology	2025	Mechanistic study of the hsa_circ_0074158 binding EIF4A3 impairing sepsis-induced endothelial barrier.	hsa_circ_0074158	circ_0074158	hsa_circ_CTNNA1	CTNNA1	sepsis	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0074158 is up-regulated in sepsis and aggravates sepsis-induced endothelial barrier dysfunction. It directly binds the RBP EIF4A3 and post-transcriptionally destabilizes its host gene CTNNA1 mRNA, reducing alpha-catenin production and increasing endothelial hyperpermeability."	0.8382
41058681	Frontiers in immunology	2025	Mechanistic study of the hsa_circ_0074158 binding EIF4A3 impairing sepsis-induced endothelial barrier.	mmu_circ_0000860	circ_Ctnna1	mmu_circ_Ctnna1	CTNNA1	sepsis	MONDO:0005229	bacterial infectious disease with sepsis	unknown	RT-qPCR	"In a CLP-induced mouse sepsis model, AAV-mediated downregulation of circ_Ctnna1 (mmu_circ_0000860) reduces lung injury and endothelial hyperpermeability, decreases serum markers of glycocalyx degradation, and lowers 7-day mortality."	0.5358
41074223	Hereditas	2025	Hsa_circ_0071271 affected the progression of non-small cell lung cancer through miR-23a-5p.	hsa_circ_0071271				non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0071271 is up-regulated in NSCLC tissues/cell lines and promotes malignant phenotypes (proliferation, migration/invasion) while inhibiting apoptosis. Mechanistically, it binds miR-23a-5p and functionally acts through the miR-23a-5p/PTEN axis. High hsa_circ_0071271 expression shows diagnostic value and is associated with poorer survival."	0.7483
41078288	Journal of cellular and molecular medicine	2025	Circular RNA Rftn1 Promotes Cardiac Hypertrophy In Vitro and In Vivo by Sponging miRNA-1192 to Upregulate Tripartite Motif Protein 25 and 41.	mmu_circ_0004641	Mus musculus circ_0004641 / circRftn1	mmu_circ_Rftn1	Rftn1	cardiac hypertrophy 	MONDO:0005045	hypertrophic cardiomyopathy	up-regulated	RT-qPCR; RNA-seq	"In AAC-induced cardiac hypertrophy and Ang II-treated NMVCs, circRftn1 (mmu_circ_0004641) is up-regulated and promotes hypertrophic phenotypes. It functions as a ceRNA by sponging miR-1192, thereby increasing TRIM25/TRIM41 expression and is associated with activation of NF-kappaB p65 signaling."	0.6436
41078372	Frontiers in physiology	2025	Identification and functional analysis of circular RNAs in intervertebral disc lesion tissues from spinal tuberculosis patients.	hsa_circ_0001021				spinal tuberculosis / STB	MONDO:0043836	"tuberculosis, spinal"	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001021 is upregulated in peripheral blood of STB patients before surgery and decreases after postoperative anti-tuberculosis treatment. It shows diagnostic value by ROC analysis and may help monitor therapeutic response, especially when combined with ESR/CRP."	0.5963
41078372	Frontiers in physiology	2025	Identification and functional analysis of circular RNAs in intervertebral disc lesion tissues from spinal tuberculosis patients.	hsa_circ_0043898				spinal tuberculosis / STB	MONDO:0043836	"tuberculosis, spinal"	up-regulated	RT-qPCR; Microarray	"hsa_circ_0043898 is upregulated in peripheral blood of STB patients before treatment and decreases after therapy, indicating value for diagnosis and postoperative monitoring. Its diagnostic performance is further improved when combined with ESR or CRP."	0.5963
41078372	Frontiers in physiology	2025	Identification and functional analysis of circular RNAs in intervertebral disc lesion tissues from spinal tuberculosis patients.	hsa_circ_0093669				spinal tuberculosis / STB	MONDO:0043836	"tuberculosis, spinal"	up-regulated	RT-qPCR; Microarray	"hsa_circ_0093669 is upregulated in peripheral blood of STB patients before treatment, decreases after therapy, and shows strong diagnostic performance as a standalone marker by ROC analysis, with additional value for postoperative therapeutic monitoring."	0.5963
41082269	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2025	"CircLRBA Promotes Epithelial-Mesenchymal Transition, Immune Evasion, Chemoimmunotherapy Resistance and Metastasis Through Stabilizing Twist1."	hsa_circ_0004636	circLRBA	hsa_circ_LRBA	LRBA	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circLRBA (hsa_circ_0004636), derived from LRBA exons 32_34, is up-regulated in breast cancer and mainly localized in the cytoplasm. It promotes EMT, metastasis, immune evasion and docetaxel/anti-PD-L1 therapy resistance by binding SPOP to block SPOP-mediated Twist1 ubiquitination, thereby stabilizing Twist1 and enhancing PD-L1 transcription; Zeb1 promotes circLRBA generation."	0.9058
41088574	Medicine	2025	Investigating the platelet autophagy effect in maintenance hemodialysis patients by whole genome transcriptome from platelets.	hsa_circ_0089788				end-stage renal disease	MONDO:0005300	chronic kidney disease	dysregulated	RNA-seq	"hsa_circ_0089788 was identified by platelet RNA-seq as a circRNA included in a predicted autophagy-related ceRNA network in MHD, potentially regulating key autophagy-associated mRNAs (e.g., VEGFA, FOXO3, CXCR4, CASP8) through miRNA competition. No experimental validation beyond sequencing/prediction was reported."	0.1768
41088574	Medicine	2025	Investigating the platelet autophagy effect in maintenance hemodialysis patients by whole genome transcriptome from platelets.	hsa_circ_0024224		hsa_circ_ATM	ATM	end-stage renal disease	MONDO:0005300	chronic kidney disease	dysregulated	RNA-seq	"hsacirc0024224 (ATM-associated) was highlighted as a key circRNA node in the predicted platelet autophagy ceRNA network in MHD, showing high competitive interaction with multiple miRNAs and potentially regulating autophagy via ATM. The evidence is based on RNA-seq differential expression and in-silico network predictions without experimental validation."	0.1768
41088574	Medicine	2025	Investigating the platelet autophagy effect in maintenance hemodialysis patients by whole genome transcriptome from platelets.	hsa_circ_0043965				end-stage renal disease	MONDO:0005300	chronic kidney disease	dysregulated	RNA-seq	hascirc0043965 was identified as a circRNA with high competitive interaction with miRNAs in an autophagy-related ceRNA network in MHD platelets. The association is based on RNA-seq differential expression and computational miRNA-target predictions without experimental validation.	0.1768
41103024	"Cancer communications (London, England)"	2025	Intranuclear paraspeckle-circular RNA TACC3 assembly forms RNA-DNA hybrids to facilitate MASH-related hepatocellular carcinoma growth in an m6A-dependent manner.		circTACC3 / hsa_circ_406433	hsa_circ_TACC3	TACC3	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circTACC3 is up-regulated and nuclear-enriched in MASH-related HCC. In lipid overload, its m6A-dependent binding to NONO/p54nrb promotes paraspeckle assembly and nuclear retention, enabling recruitment to DSB sites to form circTACC3-containing R loops that remodel chromatin (enhanced inter-TAD contacts/fusion) and activate malignant programs, promoting proliferation, lipid accumulation, and survival."	0.8227
41103217	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2025	CircSMEK1 Suppresses HCC via the hnRNPK-IGF2-AKT Axis: A Diagnostic Biomarker and Therapeutic Target.		hsa_circRNA_101427 / circSMEK1	hsa_circ_SMEK1	SMEK1	metabolic dysfunction-associated steatohepatitis / MASH	MONDO:0007027	metabolic dysfunction-associated steatohepatitis	down-regulated	RT-qPCR; RNA-seq	"circSMEK1 (derived from SMEK1) is down-regulated in MASH-HCC/HCC tissues and serum and acts as a tumor suppressor. It mainly functions in the nucleus by binding hnRNPK and promoting its ubiquitin-proteasome degradation, thereby decreasing IGF2 transcription/secretion and inhibiting PI3K/AKT signaling; restoration suppresses tumor growth and metastasis in vivo and shows diagnostic/prognostic potential in serum and tissues."	0.8973
41105618	Infection and immunity	2025	METTL3 aggravates lung injury in neonatal mice with Streptococcus pneumoniae-induced pneumonia via the circ_0001239/KLF10 axis.	mmu_circ_0001239	circular RNA_0001239 / circ_0001239			Streptococcus pneumoniae-induced pneumonia	MONDO:0005972	streptococcal pneumonia	up-regulated	RT-qPCR	"In Spn-induced pneumonia lung injury in neonatal mice, circ_0001239 is upregulated and promotes inflammatory/oxidative lung damage. METTL3 increases circ_0001239 via m6A modification and enhances its interaction with YTHDC2, which decreases KLF10 mRNA stability and downregulates KLF10, worsening injury."	0.6678
41105760	Science advances	2025	Resistance to radiation enhances metastasis by altering RNA metabolism.		"circRAB12(2,3,4,5,6) / circRAB12"	hsa_circ_RAB12	RAB12	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; RNA-seq	"In radiation-resistant TNBC cells, circRAB12 is up-regulated and functions as an HNRNPL-derived ceRNA that sponges let-7 miRNAs, lowering free let-7a and increasing ITGB3 mRNA stability/ITGbeta3 expression. Forced expression of circRAB12 rescues reduced migration in HNRNPL-knockdown radioresistant cells."	0.6263
41105760	Science advances	2025	Resistance to radiation enhances metastasis by altering RNA metabolism.		"circBACE2(2,3,4,5,6,7,8) / circBACE2"	hsa_circ_BACE2	BACE2	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; RNA-seq	"circBACE2 is up-regulated in radioresistant MDA-MB-468 cells and is part of an HNRNPL-induced ceRNA set that sponges let-7 miRNAs to enhance ITGB3 mRNA stability, supporting migration/metastatic traits under radiation resistance."	0.5988
41105760	Science advances	2025	Resistance to radiation enhances metastasis by altering RNA metabolism.		"circBIRC6(2,3,4,5,6) / circBIRC6"	hsa_circ_BIRC6	BIRC6	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; RNA-seq	"circBIRC6 is up-regulated in radioresistant TNBC cells and participates in an HNRNPL-driven ceRNA program that sponges let-7 miRNAs, contributing to increased ITGB3 mRNA stability and downstream pro-migratory behavior."	0.5415
41107944	Cell communication and signaling : CCS	2025	A novel protein cRERE encoded by a circular RNA directly targets ERK signaling to alleviate chemotherapy-induced neuropathic pain.		circRere / circ: chr5:167547693_167581074	rno_circ_Rere	Rere	neuropathic pain	MONDO:0021667	neuralgia	down-regulated	RT-qPCR; RNA-seq	"circRere is down-regulated in the rat spinal dorsal horn after vincristine and its reduction contributes to chemotherapy-induced neuropathic pain. circRere is translated via an m6A-dependent mechanism to generate cRERE, which binds ERK1 to inhibit ERK phosphorylation and suppresses the downstream CREB/IL-1beta cascade, thereby alleviating spinal central sensitization and pain behaviors."	0.8233
41117067	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2025	Hypoxia-Induced circPRELID2 Promotes Gastric Cancer Metastasis by Facilitating ZEB2 Translation via PCBP1 O-GlcNAcylation.	hsa_circ_0074389	circPRELID2	hsa_circ_PRELID2	PRELID2	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"In gastric cancer, hypoxia induces circPRELID2 via HIF1A and promotes its circularization via a DYRK1A-SFPQ-SAM68/Alu-dependent mechanism. circPRELID2 acts as a protein-interacting scaffold that retains PCBP1 in the cytoplasm and enhances OGT-mediated PCBP1 O-GlcNAcylation (Thr99), relieving PCBP1-mediated translational repression of ZEB2 to promote EMT and metastasis. High circPRELID2 in tumors associates with invasion features and poorer survival."	0.8994
41117932	Cellular and molecular life sciences : CMLS	2025	A circular RNA derived from the ryanodine receptor 2 locus controls cardiac hypertrophy and calcium handling.	hsa_circ_0112647		hsa_circ_RYR2	RYR2	heart failure / HF	MONDO:0005252	heart failure	down-regulated	RT-qPCR; RNA-seq	"circRYR2 (from the RYR2 locus) is down-regulated in hypertrophic mouse hearts after TAC and in human failing hearts. Silencing circRYR2 in murine and human cardiomyocytes promotes hypertrophic responses and impairs Ca2+ handling, while AAV-mediated overexpression is protective against hypertrophic stimulation and improves Ca2+ transient parameters, partly associated with altered SERCA2-related calcium regulatory proteins."	0.6977
41117932	Cellular and molecular life sciences : CMLS	2025	A circular RNA derived from the ryanodine receptor 2 locus controls cardiac hypertrophy and calcium handling.	mmu_circ_0000431		mmu_circ_RYR2	RYR2	heart failure / HF	MONDO:0005252	heart failure	down-regulated	RT-qPCR; RNA-seq	"circRYR2 (from the RYR2 locus) is down-regulated in hypertrophic mouse hearts after TAC and in human failing hearts. Silencing circRYR2 in murine and human cardiomyocytes promotes hypertrophic responses and impairs Ca2+ handling, while AAV-mediated overexpression is protective against hypertrophic stimulation and improves Ca2+ transient parameters, partly associated with altered SERCA2-related calcium regulatory proteins."	0.6977
41117932	Cellular and molecular life sciences : CMLS	2025	A circular RNA derived from the ryanodine receptor 2 locus controls cardiac hypertrophy and calcium handling.	hsa_circ_0066608	circST3GAL6	hsa_circ_ST3GAL6		cardiac hypertrophy 	MONDO:0005045	hypertrophic cardiomyopathy	down-regulated	RT-qPCR; RNA-seq	circST3GAL6 was identified by ventricular circRNA profiling and validated by RT-qPCR as significantly down-regulated in TAC-induced hypertrophic mouse hearts; no functional/mechanistic experiments were reported for this circRNA.	0.3213
41117932	Cellular and molecular life sciences : CMLS	2025	A circular RNA derived from the ryanodine receptor 2 locus controls cardiac hypertrophy and calcium handling.	mmu_circ_0006351	circST3GAL6	mmu_circ_ST3GAL6		cardiac hypertrophy 	MONDO:0005045	hypertrophic cardiomyopathy	down-regulated	RT-qPCR; RNA-seq	circST3GAL6 was identified by ventricular circRNA profiling and validated by RT-qPCR as significantly down-regulated in TAC-induced hypertrophic mouse hearts; no functional/mechanistic experiments were reported for this circRNA.	0.3213
41117932	Cellular and molecular life sciences : CMLS	2025	A circular RNA derived from the ryanodine receptor 2 locus controls cardiac hypertrophy and calcium handling.	hsa_circ_0000471	circN4BP2L2	hsa_circ_N4BP2L2		cardiac hypertrophy 	MONDO:0005045	hypertrophic cardiomyopathy	down-regulated	RT-qPCR; RNA-seq	circN4BP2L2 was identified by ventricular circRNA profiling and validated by RT-qPCR as significantly down-regulated in TAC-induced hypertrophic mouse hearts; no functional/mechanistic experiments were reported for this circRNA.	0.3213
41117932	Cellular and molecular life sciences : CMLS	2025	A circular RNA derived from the ryanodine receptor 2 locus controls cardiac hypertrophy and calcium handling.	mmu_circ_0012369	circN4BP2L2	mmu_circ_N4BP2L2		cardiac hypertrophy 	MONDO:0005045	hypertrophic cardiomyopathy	down-regulated	RT-qPCR; RNA-seq	circN4BP2L2 was identified by ventricular circRNA profiling and validated by RT-qPCR as significantly down-regulated in TAC-induced hypertrophic mouse hearts; no functional/mechanistic experiments were reported for this circRNA.	0.3213
41120269	Cell death & disease	2025	Circular SNX25 encoded radioresistance augmenter facilitates DNA damage repair in hepatocellular carcinoma by targeting BAG6-GET4 interaction.	hsa_circ_0004874	circSNX25	hsa_circ_SNX25	SNX25	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Northern Blot; RNA-seq	"circSNX25 (hsa_circ_0004874) is up-regulated in radioresistant HCC and correlates with poor OS/PFS in radiotherapy-treated patients. It functions mainly by encoding SNX25-215, which binds GET4 and disrupts BAG6-GET4 interaction, promoting BAG6 nuclear translocation and enhancing DNA damage repair to drive radioresistance."	0.854
41132646	Frontiers in immunology	2025	circWWC3 enhances the progression of triple-negative breast cancer by interacting with vimentin to regulate the secretion of CSF2.	hsa_circ_0001910	circWWC3	hsa_circ_WWC3	WWC3	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circWWC3 (hsa_circ_0001910), derived from WWC3, is up-regulated in TNBC tissues and cells and mainly localizes to the cytoplasm. It promotes TNBC proliferation, migration/invasion and tumor growth by binding vimentin at Ser56 to enhance EMT and increase CSF2 protein secretion, and it influences NK cell-mediated cytotoxicity."	0.8254
41132846	Acta pharmaceutica Sinica. B	2025	A novel feedback loop: CELF1/circ-CELF1/BRPF3/KAT7 in cardiac fibrosis.		circ-CELF1 / circRNA CELF1	hsa_circ_CELF1	CELF1	cardiac fibrosis	MONDO:0004994	cardiomyopathy	up-regulated	RT-qPCR	"circ-CELF1 is up-regulated in mouse MI/TGF-beta1 cardiac fibrosis models and promotes fibroblast activation, proliferation and migration, thereby aggravating fibrosis. It binds BRPF3 to inhibit its ubiquitin_proteasomal degradation and enhance nuclear BRPF3, which recruits KAT7 to increase H3K14ac at the Celf1 promoter, activating Celf1 transcription and forming a positive feedback loop that boosts circ-CELF1 biogenesis while suppressing Smad7."	0.8586
41132846	Acta pharmaceutica Sinica. B	2025	A novel feedback loop: CELF1/circ-CELF1/BRPF3/KAT7 in cardiac fibrosis.		circ-CELF1 / circRNA CELF1	mmu_circ_Celf1	Celf1	cardiac fibrosis	MONDO:0004994	cardiomyopathy	up-regulated	RT-qPCR	"circ-CELF1 is up-regulated in mouse MI/TGF-beta1 cardiac fibrosis models and promotes fibroblast activation, proliferation and migration, thereby aggravating fibrosis. It binds BRPF3 to inhibit its ubiquitin_proteasomal degradation and enhance nuclear BRPF3, which recruits KAT7 to increase H3K14ac at the Celf1 promoter, activating Celf1 transcription and forming a positive feedback loop that boosts circ-CELF1 biogenesis while suppressing Smad7."	0.8586
41136736	NPJ precision oncology	2025	ACTG1 driven splicing of P4HB gene enhances EMT and bladder cancer progression.	hsa_circ_0046263	circ_0046263	hsa_circ_P4HB	P4HB	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"circ_0046263 (derived from P4HB) is up-regulated in BLCA cells and functions downstream of ACTG1-driven splicing to promote EMT, proliferation, migration, invasion, and metastasis. Re-expression of circ_0046263 rescues the anti-tumor effects caused by ACTG1 knockdown in vitro and in vivo, and it contributes to M2 macrophage polarization/infiltration."	0.7375
41136945	BMC genomics	2025	Identification and functional analysis of circular RNAs during mitochondrial damage induced by infectious bovine rhinotracheitis virus infection in Madin-Darby bovine kidney cells.		circ_002584			infectious bovine rhinotracheitis / IBR	MONDO:0025089	infectious bovine rhinotracheitis	up-regulated	RT-qPCR; RNA-seq	circ_002584 is upregulated in IBRV-infected MDBK cells and promotes virus-induced mitochondrial damage. siRNA knockdown decreases ROS accumulation and reduces mitochondrial membrane potential depolarization.	0.6977
41136945	BMC genomics	2025	Identification and functional analysis of circular RNAs during mitochondrial damage induced by infectious bovine rhinotracheitis virus infection in Madin-Darby bovine kidney cells.		circ_004326			infectious bovine rhinotracheitis / IBR	MONDO:0025089	infectious bovine rhinotracheitis	up-regulated	RT-qPCR; RNA-seq	circ_004326 is upregulated in IBRV-infected MDBK cells and inhibits virus-induced mitochondrial damage. siRNA knockdown increases ROS accumulation and increases mitochondrial membrane potential depolarization.	0.6977
41146880	Journal of translational autoimmunity	2025	The significance of m6A-circFOXK2 in CD4+T cells from patients with rheumatoid arthritis and circFOXK2 correlates with Th17 % and autophagy.	hsa_circ_0000817	circFOXK2	hsa_circ_FOXK2	FOXK2	rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"In peripheral blood CD4+ T cells from new-onset RA patients, circFOXK2 is up-regulated while its m6A-methylated level is decreased. circFOXK2 level correlates positively with Th17% and autophagy, and ALKBH5 modulates circFOXK2 m6A level and expression; bioinformatics predicts circFOXK2 may sponge miR-486-3p/miR-409-3p and has modest diagnostic value by ROC analysis."	0.7039
41152723	Cellular & molecular biology letters	2025	Circular RNA circSLC39A10 promotes prostate cancer progression by activating Wnt signaling via the miR-936/PROX1/beta-catenin axis.	hsa_circ_0057553	circSLC39A10 / hsa_circSLC39A10	hsa_circ_SLC39A10	SLC39A10	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	"circSLC39A10 is up-regulated in prostate cancer tissues and cell lines and promotes tumor cell proliferation, migration, invasion and in vivo metastasis. Mechanistically, it acts as a cytoplasmic ceRNA sponging miR-936 to increase PROX1, which enhances CTNNB1/beta-catenin transcriptional activity and activates Wnt/beta-catenin signaling."	0.8738
41153715	Biomedicines	2025	A Retrospective Study in Colorectal Adenocarcinoma Uncovers the Potential of Circ-CCT3 as a Predictor of Tumor Recurrence.		circ-CCT3	hsa_circ_CCT3	CCT3	colorectal adenocarcinoma	MONDO:0005008	colorectal adenocarcinoma	up-regulated	RT-qPCR	"circ-CCT3 is significantly upregulated in colorectal adenocarcinoma tissues versus paired normal tissues. High circ-CCT3 levels are associated with shorter DFS and OS, and circ-CCT3 overexpression independently predicts tumor recurrence (DFS) in multivariate analysis."	0.6518
41158215	Translational cancer research	2025	"Circular RNA hsa_circ_0006522 correlates with unfavorable prognosis and promotes the proliferative, migrative, and invasive abilities of breast cancer cells."	hsa_circ_0006522		hsa_circ_EFR3A	EFR3A	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; ISH	"In breast cancer, hsa_circ_0006522 is highly expressed and mainly localized in the cytoplasm. It promotes breast cancer cell proliferation, migration, and invasion in vitro. Clinically, high hsa_circ_0006522 expression is associated with lymph node metastasis and shorter overall survival, and it may act via a predicted miRNA-sponge axis involving hsa-miR-217, hsa-miR-548b-3p, and hsa-miR-769-3p."	0.8143
41158364	Journal of thoracic disease	2025	The potential of circITFG2 as a therapeutic target in lung squamous cell carcinoma.	hsa_circ_0000374	circITFG2 / circular RNA ITFG2	hsa_circ_ITFG2	ITFG2	lung squamous cell carcinoma / LUSC	MONDO:0005097	squamous cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"circITFG2 is down-regulated in LUSC and functions as a tumor suppressor. It sponges hsa-miR-526b-5p to upregulate ITM2A, promoting autophagy-dependent PD-L1 degradation and enhancing antitumor immune activity while inhibiting proliferation, migration, and invasion."	0.867
41162865	Autophagy	2026	CircAASS alleviates renal injury and fibrosis by regulating mitochondrial homeostasis in tubular epithelial cells.		circAASS	hsa_circ_AASS	AASS	acute kidney injury / AKI	MONDO:0002492	acute kidney injury	down-regulated	RT-qPCR; ISH; RNA-seq; Microarray	"circAASS/circAass is down-regulated in AKI and fibrosis contexts and protects tubular epithelial cells by improving mitochondrial homeostasis. It promotes mitophagy via a MIR324-3p_PINK1 ceRNA mechanism and enhances mitochondrial biogenesis by binding PPARGC1A/PGC-1alpha to block RNF34-mediated ubiquitination, thereby reducing apoptosis, inflammation and subsequent renal fibrosis."	0.864
41162865	Autophagy	2026	CircAASS alleviates renal injury and fibrosis by regulating mitochondrial homeostasis in tubular epithelial cells.		circAASS	mmu_circ_Aass	AASS	acute kidney injury / AKI	MONDO:0002492	acute kidney injury	down-regulated	RT-qPCR; ISH; RNA-seq; Microarray	"circAASS/circAass is down-regulated in AKI and fibrosis contexts and protects tubular epithelial cells by improving mitochondrial homeostasis. It promotes mitophagy via a MIR324-3p_PINK1 ceRNA mechanism and enhances mitochondrial biogenesis by binding PPARGC1A/PGC-1alpha to block RNF34-mediated ubiquitination, thereby reducing apoptosis, inflammation and subsequent renal fibrosis."	0.864
41163180	Journal of translational medicine	2025	CircSipa1l1 modulates melanoma cell differentiation by activating the IGF2BP1-ARHGDIB axis and ERK signaling pathway.		m-circSipa1l1 / h-circSipa1l1	hsa_circ_Sipa1l1	Sipa1l1	melanoma	MONDO:0005105	melanoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circSipa1l1 is highly expressed in melanoma tissues/cells and functions as an oncogenic circRNA. It binds IGF2BP1 to facilitate IGF2BP1-dependent stabilization of ARHGDIB mRNA, thereby activating ERK signaling to promote cell-cycle progression and inhibit melanoma differentiation; silencing circSipa1l1 induces differentiation and suppresses xenograft tumor growth."	0.8571
41163180	Journal of translational medicine	2025	CircSipa1l1 modulates melanoma cell differentiation by activating the IGF2BP1-ARHGDIB axis and ERK signaling pathway.		m-circSipa1l1 / h-circSipa1l1	mmu_circ_Sipa1l1	Sipa1l1	melanoma	MONDO:0005105	melanoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circSipa1l1 is highly expressed in melanoma tissues/cells and functions as an oncogenic circRNA. It binds IGF2BP1 to facilitate IGF2BP1-dependent stabilization of ARHGDIB mRNA, thereby activating ERK signaling to promote cell-cycle progression and inhibit melanoma differentiation; silencing circSipa1l1 induces differentiation and suppresses xenograft tumor growth."	0.8571
41163590	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2025	Circ_0000756 Mediates Oxidative Stress and Metabolic Memory in Diabetic Neuropathy via miR-7b Suppression of NRF2/ARE Pathway.	hsa_circ_0000756	circ_0000756	hsa_circ_Atad5	Atad5	diabetic peripheral neuropathy / DPN	MONDO:0006626	diabetic neuropathy	up-regulated	RT-qPCR; RNA-seq	"In DPN rat sciatic nerve and high-glucose/metabolic-memory Schwann cell models, circ_0000756 is up-regulated and promotes oxidative stress, apoptosis, and inflammation. Mechanistically, it sponges miR-7b to increase Keap1, thereby enhancing NRF2 ubiquitination/degradation and suppressing NRF2/ARE antioxidant signaling, sustaining metabolic-memory-associated damage."	0.7453
41163590	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2025	Circ_0000756 Mediates Oxidative Stress and Metabolic Memory in Diabetic Neuropathy via miR-7b Suppression of NRF2/ARE Pathway.	rno_circ_0000756	circ_0000756	rno_circ_Atad5	Atad5	diabetic peripheral neuropathy / DPN	MONDO:0006626	diabetic neuropathy	up-regulated	RT-qPCR; RNA-seq	"In DPN rat sciatic nerve and high-glucose/metabolic-memory Schwann cell models, circ_0000756 is up-regulated and promotes oxidative stress, apoptosis, and inflammation. Mechanistically, it sponges miR-7b to increase Keap1, thereby enhancing NRF2 ubiquitination/degradation and suppressing NRF2/ARE antioxidant signaling, sustaining metabolic-memory-associated damage."	0.7453
41169933	Non-coding RNA research	2025	Aerobic exercise alleviates allergic airway inflammation by suppressing circMETTL9-mediated formation of macrophage extracellular traps.	mmu_circ_0001624	circRNA 3941 / circMETTL9	mmu_circ_METTL9	METTL9	asthma	MONDO:0004979	asthma	up-regulated	RT-qPCR; ISH; Microarray	"In OVA-induced allergic airway inflammation (asthma model), circMETTL9 is upregulated and promotes macrophage extracellular trap (MET) formation. It acts in airway epithelial cells by competing with IGFBP3 for binding to EIF4A3 (DEXDc domain), suppressing IGFBP3 and activating the CXCL12/CXCR4 axis; aerobic exercise downregulates circMETTL9 and alleviates inflammation."	0.8024
41173801	Journal of cellular and molecular medicine	2025	CircANKRD52 Augments the Growth and Invasion of Melanoma Cells by Sponging miR-141-3p and Upregulating PRKACB.	hsa_circ_0026926	circANKRD52	hsa_circ_ANKRD52	ANKRD52	melanoma	MONDO:0005105	melanoma	up-regulated	RT-qPCR; Microarray	"circANKRD52 (hsa_circ_0026926), derived from ANKRD52, is upregulated in melanoma and mainly localized in the cytoplasm. It promotes melanoma cell proliferation, invasion, angiogenesis and in vivo tumorigenesis by sponging miR-141-3p to increase PRKACB (with associated VEGF upregulation). High circANKRD52 expression correlates with poorer survival and higher tumor recurrence."	0.876
41178597	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2026	MSC Membrane-Coated circPROSC-siRNA Nanoparticles for Ameliorating Craniosynostosis by Inhibiting Premature Suture Ossification.	hsa_circ_0001788	circPROSC / si-circPROSC / si_circPROSC	hsa_circ_PROSC	PROSC	craniosynostosis	MONDO:0015469	craniosynostosis	up-regulated	RT-qPCR; Microarray	"circPROSC (hsa_circ_0001788), derived from PROSC, is up-regulated in craniosynostosis cranial suture tissues and in patient plasma. It promotes MSC osteogenic differentiation by sponging miR-6815-5p to derepress WNT3A and activate canonical Wnt/beta-catenin signaling, enhancing RUNX2-driven osteogenesis; silencing circPROSC via MSC membrane-coated siRNA nanoparticles alleviates premature coronal suture fusion in Twist1+/_ mice and supports its diagnostic/therapeutic potential."	0.8898
41178597	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2026	MSC Membrane-Coated circPROSC-siRNA Nanoparticles for Ameliorating Craniosynostosis by Inhibiting Premature Suture Ossification.	hsa_circ_0006623	circPABPC1	hsa_circ_PABPC1		craniosynostosis	MONDO:0015469	craniosynostosis	up-regulated	RT-qPCR; Microarray	circPABPC1 (hsa_circ_0006623) was identified by microarray as up-regulated in craniosynostosis cranial suture tissues and its upregulation was confirmed by RT-qPCR in an independent tissue set. No functional mechanism or downstream axis was further investigated in this study.	0.3588
41178597	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2026	MSC Membrane-Coated circPROSC-siRNA Nanoparticles for Ameliorating Craniosynostosis by Inhibiting Premature Suture Ossification.	hsa_circ_0008450	circCMTM3	hsa_circ_CMTM3		craniosynostosis	MONDO:0015469	craniosynostosis	up-regulated	RT-qPCR; Microarray	circCMTM3 (hsa_circ_0008450) was identified as up-regulated in craniosynostosis cranial suture tissues by microarray and validated by RT-qPCR. The paper did not further investigate its function or mechanism.	0.3588
41178597	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2026	MSC Membrane-Coated circPROSC-siRNA Nanoparticles for Ameliorating Craniosynostosis by Inhibiting Premature Suture Ossification.	hsa_circ_0006667	circKLHL24	hsa_circ_KLHL24		craniosynostosis	MONDO:0015469	craniosynostosis	up-regulated	RT-qPCR; Microarray	"circKLHL24 (hsa_circ_0006667) was found up-regulated in craniosynostosis cranial suture tissues by microarray and validated by RT-qPCR, but no downstream functional experiments or mechanism were reported for this circRNA."	0.3588
41184265	Cell death & disease	2025	Circular RNA FCHO2 promotes airway remodeling in COPD via regulating nuclear translocation of PTBP1 to repress the splicing of GRN pre-mRNA.	hsa_circ_0003571	circFCHO2 / mus-circFCHO2	hsa_circ_FCHO2	FCHO2	chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR; ISH; RNA-seq	"circFCHO2 is upregulated in COPD and promotes airway remodeling by driving EMT and ECM remodeling. It binds the splicing factor PTBP1 to enhance PTBP1 nuclear translocation, repressing GRN pre-mRNA splicing and lowering PGRN, which activates NF-kappaB signaling; circFCHO2 knockdown ameliorates emphysema/airway remodeling in cigarette-smoke COPD mice."	0.868
41184265	Cell death & disease	2025	Circular RNA FCHO2 promotes airway remodeling in COPD via regulating nuclear translocation of PTBP1 to repress the splicing of GRN pre-mRNA.		circFCHO2 / mus-circFCHO2	mmu_circ_FCHO2	FCHO2	chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR; ISH; RNA-seq	"circFCHO2 is upregulated in COPD and promotes airway remodeling by driving EMT and ECM remodeling. It binds the splicing factor PTBP1 to enhance PTBP1 nuclear translocation, repressing GRN pre-mRNA splicing and lowering PGRN, which activates NF-kappaB signaling; circFCHO2 knockdown ameliorates emphysema/airway remodeling in cigarette-smoke COPD mice."	0.868
41186844	Discover oncology	2025	"CircPPP1CB subtype, hsa_circ_0007439, promotes nasopharyngeal carcinoma progression by upregulating KRT1."	hsa_circ_0007439	CircPPP1CB	hsa_circ_PPP1CB	PPP1CB	nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"hsa_circ_0007439 (CircPPP1CB subtype) is up-regulated in metastatic NPC cells and in tumor tissues from NPC patients with distant metastasis. It promotes proliferation and metastatic behaviors and inhibits apoptosis by sponging miR-1275 and miR-1293 to upregulate KRT1, which activates JAK/STAT signaling and drives NPC progression in vitro and in xenograft models."	0.8817
41188916	BMC medical genomics	2025	"The molecular complexity of deep vein thrombosis was preliminarily explored based on the ceRNA network, scRNA-seq and AlphaFold 2."	hsa_circ_0095124				Deep Vein Thrombosis / DVT	MONDO:0005399	venous thromboembolism	dysregulated	RNA-seq	"This study computationally identified hsa_circ_0095124 as part of a candidate DVT ceRNA axis, potentially regulating TNFSF13B via sponging hsa-miR-3074-5p. The finding is presented as a predicted regulatory pathway without experimental in vitro validation for the circRNA."	0.1768
41194001	BMC infectious diseases	2025	Expression analysis of circ-AKT3 and circ-EGLN3 in BK polyomavirus-infected kidney transplant recipients: potential biomarkers for viral reactivation.	hsa_circ_0017252	circ-AKT3	hsa_circ_AKT3	AKT3	BKPyV-associated nephropathy / BKVAN	MONDO:0022529	BK-virus nephropathy	down-regulated	RT-qPCR	"circ-AKT3 is down-regulated in blood and urine of BKPyV-infected kidney transplant recipients and shows a negative correlation with miR-296-3p. The study supports a putative ceRNA axis in which reduced circ-AKT3 may permit increased miR-296-3p activity and contribute to repression of CDH1 (E-cadherin), with potential utility as a diagnostic biomarker for active BKPyV infection."	0.559
41194001	BMC infectious diseases	2025	Expression analysis of circ-AKT3 and circ-EGLN3 in BK polyomavirus-infected kidney transplant recipients: potential biomarkers for viral reactivation.	hsa_circ_0031594	circ-EGLN3 / circEGLN3	hsa_circ_EGLN3	EGLN3	BKPyV-associated nephropathy / BKVAN	MONDO:0022529	BK-virus nephropathy	down-regulated	RT-qPCR	"circ-EGLN3 is down-regulated in blood and urine of BKPyV-infected kidney transplant recipients and is inversely correlated with miR-1299. The study proposes a ceRNA axis where reduced circ-EGLN3 may enhance miR-1299-mediated repression of IRF7, potentially weakening antiviral immunity and serving as a highly accurate diagnostic biomarker (AUC 1.00)."	0.559
41194024	BMC cancer	2025	Role and mechanism of circ_001024 endogenous competition for miR-145-3p targeting to regulate GLUT5 in RCC.	hsa_circ_0000125	Circ_001024 / CircRNA_001024	hsa_circ_RNF115	RNF115	Renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR	"Circ_001024 is up-regulated in RCC tissues/cell lines and mainly localizes to the cytoplasm. It promotes RCC cell proliferation, migration, and invasion by sponging miR-145-3p, thereby relieving miR-145-3p-mediated repression of GLUT5."	0.8791
41194937	"Research (Washington, D.C.)"	2025	"CircUBAP2(9,12) Inhibits Nasopharyngeal Carcinoma Invasion and Metastasis by Down-regulating ZEB2 through Competitive Binding to AUF1."	hsa_circ_0001847	"circUBAP2(9,12) / circUBAP2 (9,12)"	hsa_circ_UBAP2	UBAP2	nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	down-regulated	RT-qPCR; ISH; RNA-seq	"circUBAP2(9,12) (hsa_circ_0001847), derived from UBAP2 exons 9_12, is down-regulated in nasopharyngeal carcinoma and low expression predicts poorer survival. It suppresses NPC migration/invasion/metastasis by binding the RBP AUF1 and competitively reducing AUF1 binding to ZEB2 mRNA, thereby decreasing ZEB2 mRNA stability and inhibiting EMT."	0.8986
41206041	Nucleic acids research	2025	Mirror-synchronized asymmetric CRISPR nanoswitch for single-molecule profiling of multiple circRNAs in different stages of breast cancer.		circMTO1	hsa_circ_MTO1	MTO1	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	circMTO1 is down-regulated in breast cancer tissues compared with adjacent normal tissues and can be quantified by the proposed CRISPR nanoswitch. Its measurement contributes to diagnostic discrimination and staging/progression classification (especially when combined with circCDYL).	0.559
41206041	Nucleic acids research	2025	Mirror-synchronized asymmetric CRISPR nanoswitch for single-molecule profiling of multiple circRNAs in different stages of breast cancer.		circCDYL	hsa_circ_CDYL	CDYL	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circCDYL is up-regulated in breast cancer tissues versus adjacent normal tissues and is measurable by both the CRISPR nanoswitch and RT-qPCR. Its levels contribute to diagnostic discrimination and, together with circMTO1, enable grouping of patients by stage/progression."	0.5261
41206041	Nucleic acids research	2025	Mirror-synchronized asymmetric CRISPR nanoswitch for single-molecule profiling of multiple circRNAs in different stages of breast cancer.		circHIPK3	hsa_circ_HIPK3	HIPK3	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	circHIPK3 is up-regulated in breast cancer tissues versus adjacent normal tissues and is detectable by both the CRISPR nanoswitch and RT-qPCR. In this study it serves as a clinically relevant marker for distinguishing breast cancer from normal tissue.	0.5261
41206418	Molecular psychiatry	2026	Prefrontal circHomer1 regulates synaptic and behavioral adaptations induced by cocaine.		circHomer1	hsa_circ_Homer1	Homer1	substance use disorder / SUD	MONDO:0002494	substance-related disorder	down-regulated	RT-qPCR; ISH; RNA-seq	"circHomer1 (from Homer1) is persistently down-regulated in rat PrL after repeated cocaine exposure and is also reduced in human dlPFC in cocaine use disorder. Increasing circHomer1 in PrL excitatory neurons decreases cocaine (and methamphetamine) reward behaviors and rescues cocaine-induced deficits in dendritic spine maturation and excitatory synaptic transmission, with effects linked to D1R signaling."	0.6884
41206418	Molecular psychiatry	2026	Prefrontal circHomer1 regulates synaptic and behavioral adaptations induced by cocaine.		circHomer1	rno_circ_Homer1	Homer1	substance use disorder / SUD	MONDO:0002494	substance-related disorder	down-regulated	RT-qPCR; ISH; RNA-seq	"circHomer1 (from Homer1) is persistently down-regulated in rat PrL after repeated cocaine exposure and is also reduced in human dlPFC in cocaine use disorder. Increasing circHomer1 in PrL excitatory neurons decreases cocaine (and methamphetamine) reward behaviors and rescues cocaine-induced deficits in dendritic spine maturation and excitatory synaptic transmission, with effects linked to D1R signaling."	0.6884
41207612	Neuropharmacology	2026	"Prenatal alcohol exposure induces circular and linear long non-coding RNAs, and protein-coding genes linked to proinflammatory neuroimmune function, promoting nerve injury-induced allodynia following morphine treatment."		circPan3	mmu_circ_Pan3	Pan3	prenatal alcohol exposure / PAE	MONDO:0000408	fetal alcohol spectrum disorder	up-regulated	RNA-seq	circPan3 is upregulated in spinal cord dorsal horn of allodynic PAE mice after morphine and is discussed as proinflammatory. It may act as a ceRNA by sponging miR-221 to increase PTEN and thereby promote NLRP3 inflammasome-related neuroimmune activation contributing to allodynia.	0.31
41207612	Neuropharmacology	2026	"Prenatal alcohol exposure induces circular and linear long non-coding RNAs, and protein-coding genes linked to proinflammatory neuroimmune function, promoting nerve injury-induced allodynia following morphine treatment."		circRab11 / circRab11a	mmu_circ_Rab11a	Rab11a	prenatal alcohol exposure / PAE	MONDO:0000408	fetal alcohol spectrum disorder	up-regulated	RNA-seq	"circRab11/circRab11a is upregulated in the spinal cord in allodynic PAE mice after morphine. The paper discusses it as a proinflammatory circRNA that may sponge miR-24-5p and miR-433-3p, thereby favoring inflammatory signaling relevant to pain susceptibility."	0.31
41207612	Neuropharmacology	2026	"Prenatal alcohol exposure induces circular and linear long non-coding RNAs, and protein-coding genes linked to proinflammatory neuroimmune function, promoting nerve injury-induced allodynia following morphine treatment."		circNr3c2	mmu_circ_Nr3c2	Nr3c2	prenatal alcohol exposure / PAE	MONDO:0000408	fetal alcohol spectrum disorder	down-regulated	RNA-seq	"circNr3c2 is downregulated in the spinal cord in the allodynic PAE+morphine condition. The paper describes circNr3c2 as anti-inflammatory (via vimentin degradation impacting NLRP3 inflammasome scaffolding), implying that its reduction may remove a brake on proinflammatory neuroimmune activation contributing to allodynia."	0.31
41207612	Neuropharmacology	2026	"Prenatal alcohol exposure induces circular and linear long non-coding RNAs, and protein-coding genes linked to proinflammatory neuroimmune function, promoting nerve injury-induced allodynia following morphine treatment."		circAnkrd12	mmu_circ_Ankrd12	Ankrd12	prenatal alcohol exposure / PAE	MONDO:0000408	fetal alcohol spectrum disorder	down-regulated	RNA-seq	"circAnkrd12 is downregulated in spinal cord of allodynic PAE mice after morphine treatment and is described as having protective roles against inflammation. The discussion links loss of circAnkrd12 function to increased NF-kappaB signaling, suggesting its reduction could contribute to proinflammatory neuroimmune activation associated with allodynia."	0.31
41207612	Neuropharmacology	2026	"Prenatal alcohol exposure induces circular and linear long non-coding RNAs, and protein-coding genes linked to proinflammatory neuroimmune function, promoting nerve injury-induced allodynia following morphine treatment."		circAdam10	mmu_circ_Adam10	Adam10	prenatal alcohol exposure / PAE	MONDO:0000408	fetal alcohol spectrum disorder	up-regulated	RNA-seq	circAdam10 (from Adam10) is upregulated in the spinal cord in the morphine-induced allodynic PAE condition versus non-allodynic groups. The study discusses predicted miRNA interactions (including miR-509-5p) linking circAdam10 to oxidative stress/inflammatory regulation and TLR4-NF-kappaB-related signaling in this pain context.	0.31
41207612	Neuropharmacology	2026	"Prenatal alcohol exposure induces circular and linear long non-coding RNAs, and protein-coding genes linked to proinflammatory neuroimmune function, promoting nerve injury-induced allodynia following morphine treatment."		CircAtrnl1	mmu_circ_Atrnl1	Atrnl1	prenatal alcohol exposure / PAE	MONDO:0000408	fetal alcohol spectrum disorder	down-regulated	RNA-seq	"circAtrnl1 is downregulated in spinal cord in allodynic PAE mice compared with non-allodynic groups. Bioinformatic prediction (CircNetVis) suggests it may bind the miR-34/449 family, potentially influencing neuroimmune signaling relevant to pain processing."	0.31
41207612	Neuropharmacology	2026	"Prenatal alcohol exposure induces circular and linear long non-coding RNAs, and protein-coding genes linked to proinflammatory neuroimmune function, promoting nerve injury-induced allodynia following morphine treatment."		CircPtprd	mmu_circ_Ptprd	Ptprd	prenatal alcohol exposure / PAE	MONDO:0000408	fetal alcohol spectrum disorder	down-regulated	RNA-seq	"circPtprd is downregulated in spinal cord in allodynic PAE mice relative to non-allodynic groups. Bioinformatic prediction suggests it contains binding sites for miR-503 and miR-433 and is part of predicted networks regulating inflammatory mRNAs (e.g., Hmgb1) and immune-related targets (e.g., Rspo3), implicating it in neuroimmune signaling relevant to allodynia."	0.31
41207612	Neuropharmacology	2026	"Prenatal alcohol exposure induces circular and linear long non-coding RNAs, and protein-coding genes linked to proinflammatory neuroimmune function, promoting nerve injury-induced allodynia following morphine treatment."		CircApp	mmu_circ_App	App	prenatal alcohol exposure / PAE	MONDO:0000408	fetal alcohol spectrum disorder	up-regulated	RNA-seq	"circApp/circAPP is highlighted as elevated in allodynic PAE mice relative to non-PAE controls (despite being downregulated by morphine vs vehicle within PAE). Predicted networks suggest circApp may bind miR-433 (and other miRNAs), influencing Hmgb1 and downstream TLR4/NLRP3-related proinflammatory signaling relevant to pain processing."	0.31
41208880	International journal of biological sciences	2025	Dysregulation of SRSF3/circSAMD4/CIRBP Axis Promotes Iodinated Contrast-induced Acute Kidney Injury.	hsa_circ_0004846	circSAMD4	hsa_circ_SAMD4A	SAMD4A	acute kidney injury / AKI	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR; ISH	"circSAMD4 is up-regulated in iodinated contrast-induced kidney injury and promotes renal tubular epithelial cell apoptosis. It binds CIRBP and inhibits its nuclear import, driving CIRBP cytoplasmic accumulation and pro-apoptotic signaling, while SRSF3 downregulation contributes to circSAMD4 upregulation."	0.7698
41208880	International journal of biological sciences	2025	Dysregulation of SRSF3/circSAMD4/CIRBP Axis Promotes Iodinated Contrast-induced Acute Kidney Injury.		circSamd4 / mmu_circRNA_005305	mmu_circ_Samd4	Samd4	acute kidney injury / AKI	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR; ISH; Microarray	"circSamd4 is up-regulated in mouse CI-AKI kidneys, mainly in RTECs. In vivo knockdown of circSamd4 ameliorates renal dysfunction and tubular injury, reduces tubular cell death and decreases inflammatory cytokine/chemokine expression, indicating a pathogenic role in CI-AKI."	0.4935
41213916	Cell death & disease	2025	The N6-methyladenosine-mediated cLMNB1 degrades FGFR4 to overcome osimertinib resistance in non-small cell lung cancer.	hsa_circ_0007726	circRNA LMNB1 / cLMNB1	hsa_circ_LMNB1	LMNB1	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; ISH; RNA-seq	"cLMNB1 is down-regulated in osimertinib-resistant LUAD and functions as a protein scaffold that promotes c-Cbl-mediated K48-linked ubiquitination and proteasomal degradation of FGFR4, thereby restoring osimertinib sensitivity. METTL3 installs m6A marks and YTHDF2 promotes cLMNB1 degradation; an m6A-site mutant (cLMNB1-mut), including LNP delivery, shows enhanced preclinical efficacy against resistance."	0.8875
41213916	Cell death & disease	2025	The N6-methyladenosine-mediated cLMNB1 degrades FGFR4 to overcome osimertinib resistance in non-small cell lung cancer.	hsa_circ_0043954	cBRCA1	hsa_circ_BRCA1	BRCA1	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RNA-seq	"cBRCA1 (has_circ_0043954) was identified as down-regulated in osimertinib-resistant LUAD during sequencing-based screening, but functional assays did not show an effect on resistant cell growth under osimertinib compared with cLMNB1; no mechanism was established for cBRCA1 in this study."	0.1848
41214390	EMBO molecular medicine	2025	circ-EGFR is a predictor of response to Cetuximab and a potential target in colorectal cancer.	hsa_circ_0080230	circ-EGFR	hsa_circ_EGFR	EGFR	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ-EGFR (hsa_circ_0080230), derived from EGFR, is upregulated in cetuximab responders and cetuximab-sensitive CRC cells and serves as a predictor of anti-EGFR therapy response in mCRC. Functionally, it increases cetuximab sensitivity and promotes apoptosis under cetuximab treatment. Mechanistically, it sponges miR-942-3p to upregulate GAS1, activating Hedgehog signaling to enhance cetuximab efficacy."	0.8871
41217541	Clinical and experimental medicine	2025	Construction of a prognostic model for nasopharyngeal carcinoma based on serum exosomal circular RNAs and analysis of immune microenvironment.	hsa_circ_0036783				nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	down-regulated	RT-qPCR; Microarray	hsa_circ_0036783 is down-regulated in nasopharyngeal carcinoma and was included in a serum-exosomal circRNA_miRNA_mRNA ceRNA network constructed for NPC.	0.5135
41217541	Clinical and experimental medicine	2025	Construction of a prognostic model for nasopharyngeal carcinoma based on serum exosomal circular RNAs and analysis of immune microenvironment.	hsa_circ_0011333				nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circ_0011333 is up-regulated in nasopharyngeal carcinoma and was incorporated into a serum-exosomal circRNA_miRNA_mRNA ceRNA network in this study.	0.5135
41217541	Clinical and experimental medicine	2025	Construction of a prognostic model for nasopharyngeal carcinoma based on serum exosomal circular RNAs and analysis of immune microenvironment.	hsa_circ_0048410				nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circ_0048410 is up-regulated in nasopharyngeal carcinoma and was used to build a serum-exosomal circRNA_miRNA_mRNA ceRNA network in this work.	0.5135
41219790	Molecular cancer	2025	A novel protein cPFKFB4 encoded by hsa_circ_0065394 strengthens PKM2-mediated glucose metabolic reprogramming to facilitate pancreatic cancer progression under hypoxia.	hsa_circ_0065394		hsa_circ_PFKFB4	PFKFB4	pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; ISH	"hsa_circ_0065394 is up-regulated in pancreatic cancer, especially under hypoxia, and promotes tumor cell proliferation, migration/invasion and in vivo growth. It encodes an IRES-driven protein cPFKFB4 that binds hnRNP G, disrupts hnRNP G_hnRNP A1 interaction, enhances PKM alternative splicing toward PKM2, and increases glycolysis."	0.8999
41221017	Mediators of inflammation	2025	Circ_0058051 Targeted miR-129-5P Regulates Autophagy-Related Gene ATG7 to Promote the Inflammation of Gout.	hsa_circ_0058051	circ_0058051 / circ-0058051	hsa_circ_BARD1	BARD1	gout	MONDO:0005393	gout	up-regulated	RT-qPCR	"circ_0058051 is up-regulated in PBMCs from gout patients, especially during attack and recurrence. It promotes gouty inflammatory responses by acting as a ceRNA that sponges miR-129-5p, thereby increasing ATG7 and enhancing ATG7-mediated autophagy and pro-inflammatory cytokine production in MSU-stimulated macrophages."	0.6369
41221627	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2026	Dysregulation of CircZNF79(5) Modulates YBX1 Stability and Selective Autophagy to Drive Hepatocellular Carcinoma Progression.	hsa_circ_0006984	circZNF79(5) / circZNF79	hsa_circ_ZNF79	ZNF79	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circZNF79(5) is upregulated in HCC tissues and serum exosomes and is mainly localized in the cytoplasm. It promotes HCC proliferation/migration/invasion and inhibits apoptosis by binding YBX1 and recruiting BRCC36 to remove K63-linked ubiquitin chains, stabilizing YBX1 and enhancing downstream HIF-1 signaling, while preventing p62-mediated selective autophagic degradation of YBX1 via AMPK/mTOR."	0.8933
41225028	Scientific reports	2025	Circular RNA circNRIP1 promotes glioma progression by regulating the miR-106a-5p/GPR133 pathway.	hsa_circ_0002711	circNRIP1	hsa_circ_NRIP1	NRIP1	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circNRIP1 is up-regulated in glioma tissues and cell lines and is associated with poorer overall survival. It promotes glioma malignant phenotypes (proliferation, migration, invasion, EMT) and tumor growth by sponging miR-106a-5p to upregulate GPR133 (circNRIP1/miR-106a-5p/GPR133 axis)."	0.7408
41226594	International journal of molecular sciences	2025	Differential Expression of Circular RNAs in Rat Brain Regions with Various Degrees of Damage After Ischemia-Reperfusion.		circMvp-7.4	rno_circ_Mvp	Mvp	ischemia reperfusion injury / IRI	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR; RNA-seq	circMvp-7.4 is up-regulated in rat striatum 24 h after tMCAO (ischemia_reperfusion injury) and its differential expression was supported by RNA-seq and validated by RT-qPCR. No circMvp-7.4-specific downstream mechanism was experimentally established in this study.	0.4625
41226594	International journal of molecular sciences	2025	Differential Expression of Circular RNAs in Rat Brain Regions with Various Degrees of Damage After Ischemia-Reperfusion.		circPde10a-18.17	rno_circ_Pde10a	Pde10a	ischemia reperfusion injury / IRI	MONDO:0005203	ischemia reperfusion injury	down-regulated	RT-qPCR; RNA-seq	circPde10a-18.17 is down-regulated in rat striatum 24 h after tMCAO and this expression change was consistent between RNA-seq and RT-qPCR. Its circular back-splice junction (between exons 18 and 17) was confirmed by PCR and Sanger sequencing.	0.6571
41226594	International journal of molecular sciences	2025	Differential Expression of Circular RNAs in Rat Brain Regions with Various Degrees of Damage After Ischemia-Reperfusion.		circFgfr1-12.10	rno_circ_Fgfr1	Fgfr1	ischemia reperfusion injury / IRI	MONDO:0005203	ischemia reperfusion injury	up-regulated	RNA-seq	"circFgfr1-12.10 is up-regulated after tMCAO and is included in predicted ceRNA axes in both striatum and frontal cortex, exemplified by circFgfr1-12.10/rno-miR-665/Fgfr1. The authors suggest it may help protect Fgfr1 activity and support post-ischemic restoration processes such as angiogenesis/revascularization, but this network is not functionally validated experimentally."	0.31
41226594	International journal of molecular sciences	2025	Differential Expression of Circular RNAs in Rat Brain Regions with Various Degrees of Damage After Ischemia-Reperfusion.		circAdamts9-27.22	rno_circ_Adamts9	Adamts9	ischemia reperfusion injury / IRI	MONDO:0005203	ischemia reperfusion injury	up-regulated	RNA-seq	"circAdamts9-27.22 is up-regulated after tMCAO and is one of the circRNAs differentially expressed in both striatum and frontal cortex. It is included in the in-silico circRNA_miRNA_mRNA competitive network (common axes across both regions), but the specific downstream miRNA/mRNA partners for this circRNA were not detailed in the provided text and were not functionally validated."	0.31
41226594	International journal of molecular sciences	2025	Differential Expression of Circular RNAs in Rat Brain Regions with Various Degrees of Damage After Ischemia-Reperfusion.		circGli3-11.5 / circGli3-11.7			ischemia reperfusion injury / IRI	MONDO:0005203	ischemia reperfusion injury	down-regulated	RNA-seq	circGli3-11.5 and circGli3-11.7 are down-regulated in ischemic rat striatum and are predicted to interact with miR-3473b within the study¡¯s in-silico circRNA_miRNA_mRNA regulatory network. No experimental validation specific to these circRNAs was reported beyond RNA-seq and computational predictions.	0.31
41226594	International journal of molecular sciences	2025	Differential Expression of Circular RNAs in Rat Brain Regions with Various Degrees of Damage After Ischemia-Reperfusion.		circCttnbp2-15.9	rno_circ_Cttnbp2	Cttnbp2	ischemia reperfusion injury / IRI	MONDO:0005203	ischemia reperfusion injury	down-regulated	RNA-seq	"circCttnbp2-15.9 is down-regulated in ischemic rat striatum and is highlighted as a striatum-specific DEC involved in predicted regulation of striatum-specific pathways. The study proposes an in-silico ceRNA axis circCttnbp2-15.9/rno-miR-25-3p/Cyp2j3, but does not provide experimental validation of this axis."	0.31
41228362	Cancers	2025	CircATP2C1 Drives Prostate Cancer Progression Through miR-654-3p-Mediated SLC7A11 Upregulation and Ferroptosis Suppression.		circATP2C1	hsa_circ_ATP2C1	ATP2C1	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; ISH	"circATP2C1 is up-regulated in prostate cancer and mainly localized in the cytoplasm. It promotes proliferation, migration/invasion and tumor growth by acting as a ceRNA that sponges miR-654-3p, thereby upregulating SLC7A11 (and GPX4) to suppress ferroptosis; high expression correlates with worse overall survival and adverse clinicopathologic features."	0.8837
41229443	Turkish journal of biology = Turk biyoloji dergisi	2025	hsa_circ_0001776 regulates the progression of acute myeloid leukemia through the miR-1269b/PTEN axis.	hsa_circ_0001776	hsa_circRNA_104547 / circ_0001776	hsa_circ_ESYT2	ESYT2	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	down-regulated	RT-qPCR; Microarray	"hsa_circ_0001776 is down-regulated in AML peripheral blood and inhibits AML cell proliferation by inducing G0/G1 arrest. Mechanistically, it functions as a ceRNA that sponges miR-1269b, thereby relieving repression of PTEN and suppressing AML progression. It shows diagnostic potential based on ROC analysis in a small clinical cohort."	0.8357
41230432	Non-coding RNA research	2026	circMRPL35 promotes gastric cancer progression through the miR-6809-3p/ZNF90 axis and affects the EMT process and TGF-beta1/SMAD2/3 signaling.	hsa_circ_00055521	circMRPL35	hsa_circ_MRPL35	MRPL35	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circMRPL35 is upregulated in gastric cancer tissues and cell lines and promotes GC cell proliferation, migration/invasion, EMT, and in vivo tumor growth while inhibiting apoptosis. Mechanistically, it acts as a ceRNA that sponges miR-6809-3p to increase ZNF90, thereby activating the TGF-beta1/SMAD2/3 signaling axis."	0.8072
41243274	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2026	The Evolutionarily Conserved TPM1 Super-Enhancer Drives Skeletal Muscle Regeneration via Mechanotransduction Signaling.		CircTPM1	bta_circ_TPM1	TPM1	skeletal muscle regeneration	MONDO:0020120	skeletal muscle disorder	up-regulated	RT-qPCR; RNA-seq	"CircTPM1 (a TPM1-derived bovine circRNA) is upregulated during myogenic differentiation and promotes myotube formation and muscle regeneration. Mechanistically, it sponges bta-miR-22-5p to de-repress NKX2.2 and activate PI3K/AKT signaling, and it also directly binds MYH10 to enhance MYL3-dependent actomyosin assembly and cytoskeletal remodeling."	0.7897
41253948	Scientific reports	2025	CircPSMA4 as a novel circular RNA enhances the proliferation migration invasion and metabolism of bladder cancer cells through the miR-767-3p/HIF1A pathway.		circPSMA4 / circRNA PSMA4	hsa_circ_PSMA4	PSMA4	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circPSMA4 is up-regulated in bladder cancer tissues/cells and mainly localized in the cytoplasm. It promotes proliferation, migration, invasion, tumor growth and glycolytic/Warburg-like metabolism by sponging miR-767-3p and upregulating HIF1A (circPSMA4/miR-767-3p/HIF1A axis)."	0.7799
41255835	Iranian journal of biotechnology	2025	CircFNIP1 Regulates Proliferation and Invasion in Lung Cancer Cells and Represents a Potential Therapeutic Target.	hsa_circ_0073858	circFNIP1 / circ_0073858	hsa_circ_FNIP1	FNIP1	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circFNIP1 is up-regulated in lung cancer cell lines and functions as an oncogenic circRNA by promoting proliferation, colony formation, migration and invasion in vitro and tumor growth in vivo. The study proposes a potential circFNIP1_miR-657_ICAM1 ceRNA axis based on bioinformatics and expression correlation, but notes that this axis requires experimental validation."	0.5098
41257248	NAR molecular medicine	2024	A novel circRNA-miRNA-mRNA regulatory axis as a sex-specific biological variable in bronchopulmonary dysplasia.		circNfix	hsa_circ_Nfix	Nfix	Bronchopulmonary Dysplasia / BPD	MONDO:0019091	bronchopulmonary dysplasia	up-regulated	RT-qPCR; RNA-seq	"circNfix/circNFIX is upregulated in BPD (notably in males) and participates in a circRNA_miRNA_mRNA axis involving miR204-5p (and miR-211-5p) and Ntrk2/NTRK2. Silencing circNfix with a BSJ-targeting GapmeR reduces Ntrk2 protein and improves BPD-associated alveolar injury, with increased proliferation and angiogenesis/vasculogenesis in treated BPD male pups; the axis is also supported in human male infant BPD lung samples."	0.7907
41257248	NAR molecular medicine	2024	A novel circRNA-miRNA-mRNA regulatory axis as a sex-specific biological variable in bronchopulmonary dysplasia.		circNfix	mmu_circ_Nfix	Nfix	Bronchopulmonary Dysplasia / BPD	MONDO:0019091	bronchopulmonary dysplasia	up-regulated	RT-qPCR; RNA-seq	"circNfix/circNFIX is upregulated in BPD (notably in males) and participates in a circRNA_miRNA_mRNA axis involving miR204-5p (and miR-211-5p) and Ntrk2/NTRK2. Silencing circNfix with a BSJ-targeting GapmeR reduces Ntrk2 protein and improves BPD-associated alveolar injury, with increased proliferation and angiogenesis/vasculogenesis in treated BPD male pups; the axis is also supported in human male infant BPD lung samples."	0.7907
41257982	Scientific reports	2025	Circ_0003266 suppresses bladder cancer progression by modulating the miR-503-5p/SMAD7/TGF-beta signaling axis.	hsa_circ_0003266	circ_0003266			bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; Microarray	"circ_0003266 is down-regulated in bladder cancer tissues and cell lines and functions as a tumor suppressor. It sponges miR-503-5p to increase SMAD7, thereby inhibiting TGF-beta/SMAD signaling and reducing proliferation/migration while promoting apoptosis, including suppressing xenograft growth."	0.8324
41258511	Scientific reports	2025	circRNA-associated-ceRNA networks in patients with traumatic tracheal stenosis.		circ_030284 / hsa_circ_030284			Traumatic tracheal stenosis / TTS	MONDO:0002567	tracheal disorder	up-regulated	RT-qPCR; RNA-seq	"In TTS granulation tissues, circ_030284 is up-regulated and forms a ceRNA axis with miR-1207-5p and S100A2. The study suggests circ_030284 may sponge miR-1207-5p, relieving repression on S100A2 and thereby contributing to TTS pathogenesis."	0.4032
41262880	International journal of general medicine	2025	Potential Diagnostic Value of Circular RNA hsa_circ_0008882 in Rheumatic Valvular Heart Disease.	hsa_circ_0008882	circ_0008882_z-score			rheumatic valvular heart disease / RVHD	MONDO:0006955	rheumatic heart disease	up-regulated	RT-qPCR; Microarray	"hsa_circ_0008882 is up-regulated in RVHD plasma and valve tissues and shows moderate diagnostic value (AUC 0.707) and independent association with RVHD risk. Mechanistically, it binds hsa-miR-4739, and a putative hsa_circ_0008882/miR-4739/CAMTA2(or APLN) ceRNA axis is proposed based on bioinformatics prediction and gene upregulation."	0.7469
41262976	Frontiers in neurology	2025	Uncovering the new landscape of leukoaraiosis through the circular RNA-miRNA-mRNA axis.	hsa_circ_0018401	circ_0018401 / circ-0018401			leukoaraiosis / LA	MONDO:0011057	cerebrovascular disorder	up-regulated	RT-qPCR	"In leukoaraiosis/white matter injury, circ_0018401 is up-regulated in patient whole blood and binds miR-145-5p, consistent with a ceRNA-like mechanism. Through miR-145-5p, it is linked to increased AIFM1 (an apoptosis-related gene) and may contribute to OPC apoptosis, supporting its potential as a biomarker and therapeutic target."	0.6102
41264059	Discover oncology	2025	Hsa_circ_0062522 affects the progression and tamoxifen resistance of estrogen receptor-positive breast cancer by targeting miR-3163.	hsa_circ_0062522	circ_0062522			estrogen receptor-positive breast cancer / ER+ breast cancer	MONDO:0006512	estrogen-receptor positive breast cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0062522 is up-regulated in ER+ breast cancer tissues and cells and promotes malignant phenotypes, including proliferation/viability and migration, while inhibiting apoptosis. It enhances tamoxifen resistance by targeting (negatively regulating) miR-3163; miR-3163 mimic partially reverses these effects. In xenograft models, silencing hsa_circ_0062522 reduces tumor growth and improves tamoxifen sensitivity."	0.7357
41274972	Scientific reports	2025	"hsa_circ_0001818 regulates the function of macrophages in sepsis by inhibiting miR-17-3p, miR-433-3p, and miR-642a-5p."	hsa_circ_0001818	hsa_circRNA_104670	hsa_circ_UBR5	UBR5	sepsis	MONDO:0005229	bacterial infectious disease with sepsis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001818 is up-regulated in LPS-induced septic macrophages and (previously) in serum exosomes of sepsis patients. It functions as a ceRNA to sponge miR-17-3p, miR-433-3p and miR-642a-5p, thereby promoting CASP3-associated apoptosis and enhancing inflammatory cytokine secretion via the ZBTB20/NF-kappaB axis while suppressing macrophage phagocytosis."	0.7204
41275291	Journal of translational medicine	2025	NSUN7-mediated m5C modification of circNTRK2 regulates stemness properties of glioblastoma cells by activating STK31.	hsa_circ_0139157	circNTRK2	hsa_circ_NTRK2	NTRK2	glioblastoma / GBM	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR	"circNTRK2 is down-regulated in GBM and suppresses GBM stemness when overexpressed. NSUN7 installs an m5C mark (C158) on circNTRK2 that enables YBX3 binding and destabilization of circNTRK2; circNTRK2 also binds and activates STK31 to modulate IKZF1 activity and downstream stemness markers (DCLK1, OCT4)."	0.7529
41280375	"Diabetes, metabolic syndrome and obesity : targets and therapy"	2025	Diagnostic Roles of circXPNPEP3 as Biomarker for Diabetic Nephropathy.	hsa_circ_0008360	circXPNPEP3	hsa_circ_XPNPEP3	XPNPEP3	Diabetic nephropathy / DN	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"circXPNPEP3 (hsa_circ_0008360), derived from XPNPEP3, is up-regulated in DN kidney tissues and patient serum and shows diagnostic potential (ROC AUC 0.8389). A bioinformatically predicted ceRNA network suggests it may sponge hsa-miR-135b-5p/hsa-miR-135a-3p/hsa-miR-1237-3p and thereby affect downstream genes such as SOX4, CREB5, ZFP36L1, GRAMD1B, and PROM1, potentially contributing to DN progression."	0.459
41284124	Discover oncology	2025	CircFAT1(e2) acts as a sponge for miR-30e-5p and inhibits glioma progression by regulating MYBL2-mediated cell proliferation.		circFAT1(e2) / circFAT1 (e2)	hsa_circ_FAT1	FAT1	glioma	MONDO:0021042	glioma	unknown	RT-qPCR; Northern Blot	"circFAT1(e2) functions as a cytoplasmic ceRNA that sponges miR-30e-5p, thereby relieving repression of MYBL2. Functionally, circFAT1(e2) supports glioma cell proliferation, cell-cycle progression, migration/invasion, and resistance to apoptosis, and its knockdown suppresses tumor growth in a xenograft model."	0.7527
41287824	MedComm	2025	circRNA-SORE/UBQLN1/GPX4 Mediates the Acquisition of Sorafenib Resistance in Hepatocellular Carcinoma Through Inhibition of Ferroptosis.		circRNA_SORE / circRNA_104797			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circRNA-SORE is up-regulated in sorafenib-resistant HCC cells and promotes drug resistance by reducing ROS and suppressing ferroptosis. It directly binds and stabilizes UBQLN1, which in turn stabilizes GPX4 and preserves redox/mitochondrial homeostasis under sorafenib-induced stress."	0.6562
41291552	BMC cancer	2025	Transcription factor FOXC2 regulates miR-145/ADAMTS5 axis to inhibit angiogenesis in hepatocellular carcinoma via circular RNA 0002898.	hsa_circ_0002898	circular RNA 0002898 / cyclic RNA0002898	hsa_circ_DNAJC16	DNAJC16	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; ISH	"circ0002898 (from DNAJC16) is down-regulated in HCC and acts as a tumor suppressor. FOXC2 promotes circ0002898 expression, while circ0002898 sponges miR-145 to restore ADAMTS5 expression, thereby inhibiting HCC proliferation/migration/invasion and suppressing tumor angiogenesis; higher circ0002898 associates with better patient survival and has diagnostic value."	0.8997
41300734	Genes	2025	"Molecular Characteristics, Circularization Mechanism, and Potential Functions of circRNA-0172."		circRNA-0172	gga_circ_MDM2	MDM2	Avian leukosis virus subgroup J (ALV-J) infection	MONDO:0005108	viral infectious disease	down-regulated	RT-qPCR; RNA-seq	"In chicken cells, circRNA-0172 (derived from MDM2 exons 3_11) is down-regulated upon ALV-J infection and is mainly localized in the cytoplasm. Overexpression of circRNA-0172 suppresses DF-1 cell proliferation and enhances apoptosis, accompanied by decreased Bcl2 and increased CCND1, and it is predicted to participate in a ceRNA network involving multiple gga-miRNAs and MDM2-related regulation."	0.7331
41307824	Discover oncology	2025	hsa_circ_0135681 functions as a novel tumor-suppressive circular RNA regulating Glycolysis and EMT to attenuate cisplatin resistance in non-small cell lung cancer.	hsa_circ_0135681		hsa_circ_MTSS1	MTSS1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	"This study identifies hsa_circ_0135681 as significantly downregulated in NSCLC tissues and links its low expression to worse patient overall survival. Forced overexpression suppresses cisplatin-resistant NSCLC cell growth and migration while promoting apoptosis, and inhibits tumor growth in a xenograft model. Mechanistically, it reduces glycolysis (lower glucose consumption/lactate production and decreased HK2/PFKM) and inhibits EMT; a putative hsa-miR-4299_RNF180/SOCS5 regulatory network is proposed mainly from bioinformatics and expression changes."	0.7628
41310793	European journal of medical research	2025	Targeting CircNLRP12 attenuates hypoxia-induced pulmonary arterial smooth muscle cell dysfunction by sponging miR-107-5p and suppressing the ITGA2-mediated FAK/PI3K/AKT pathway.		circNLRP12 / novel_circ_0012677	hsa_circ_NLRP12	NLRP12	pulmonary arterial hypertension / PAH	MONDO:0015924	pulmonary arterial hypertension	up-regulated	RT-qPCR; RNA-seq	"circNLRP12 is up-regulated in peripheral blood of PAH-CHD patients and in hypoxia-exposed hPASMCs. It promotes hypoxia-induced hPASMC proliferation and migration and suppresses apoptosis by sponging miR-107-5p, thereby upregulating ITGA2 and activating the FAK/PI3K/AKT/HIF-1alpha cascade (with effects on VEGF and alpha-SMA), contributing to vascular remodeling."	0.7968
41313404	Discover oncology	2025	MiR-205-5p downregulation and circ_100290 upregulation in glioblastoma patients are associated with tumor aggressiveness.		circ_100290 / circRNA_100290			glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; Microarray	"circ_100290 is up-regulated in GBM patient tumor tissues versus normal tissues and its higher expression is associated with IDH1 mutation status. Bioinformatics suggests it participates in a ceRNA network with miR-205-5p and is linked to key proteins (e.g., PTEN, SMAD4, EIF4A3) and pathways including Wnt signaling."	0.4032
41318550	Biological research	2025	Hsa_circ_0003611 hinders the transformation of mesenchymal stem cells into osteosarcoma cells through suppressing MYC by IGF2BP3 via m6A modification.	hsa_circ_0003611		hsa_circ_LPAR1	LPAR1	osteosarcoma / OS	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0003611 is markedly reduced in osteosarcoma cells and acts as a suppressor of MSC-to-osteosarcoma transformation. It binds IGF2BP3, limiting IGF2BP3_MYC mRNA association and MYC mRNA stability; m6A modification weakens the hsa_circ_0003611_IGF2BP3 interaction, diminishing this inhibitory effect."	0.8476
41319483	"Clinics (Sao Paulo, Brazil)"	2025	Integrated analysis of metastasis-related circRNA-miRNA-mRNA ceRNA regulatory network involved in breast cancer.	hsa_circ_0089131	circ_0089131			breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	hsa_circ_0089131 is up-regulated in breast cancer tissues and is proposed to participate in a ceRNA network by associating with miR-378a-3p and TP53. The constructed axis links to PI3K-Akt and MAPK signaling pathways and is discussed in the context of metastasis-related regulation.	0.4997
41323393	Frontiers in oncology	2025	Circ_0060927 regulates miR-331-3p/ERK/MAPK pathway reaction in non-small cell lung cancer through METTL14-driven methylation.	hsa_circ_0060927	circ_0060927	hsa_circ_CYP24A1	CYP24A1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0060927 is up-regulated in NSCLC cell lines and promotes proliferation, migration/invasion, and reduces apoptosis. Mechanistically, METTL14-driven m6A methylation increases circ_0060927 levels, enabling it to sponge miR-331-3p, derepress MAP2K7, and activate the ERK/MAPK signaling cascade."	0.5992
41326569	Scientific reports	2025	The circRNA circKNSTRN promotes breast cancer progression by modulating the miR-320a-3p/SPAG5 axis.	hsa_circ_0103433	circKNSTRN	hsa_circ_KNSTRN	KNSTRN	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circKNSTRN (hsa_circ_0103433), derived from KNSTRN, is up-regulated in breast cancer tissues and cell lines and predominantly localizes in the cytoplasm. It promotes breast cancer cell proliferation and migration, and modulates apoptosis and the cell cycle, mainly by sponging miR-320a-3p to increase SPAG5 expression via a ceRNA (circKNSTRN/miR-320a-3p/SPAG5) axis."	0.8625
41327336	Molecular brain	2025	Dysregulated circRNA-miRNA-mRNA networks reveal stage-specific mRNA expression changes in Parkinson's disease.		circPRDM2	hsa_circ_PRDM2	PRDM2	Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	up-regulated	RNA-seq	"circPRDM2 is computationally identified from whole-blood RNA-seq as uniquely up-regulated at the V04 PD stage and is predicted to participate in a stage-specific ceRNA network, showing positive correlation with the up-regulated target mRNA CACNG8."	0.1768
41327336	Molecular brain	2025	Dysregulated circRNA-miRNA-mRNA networks reveal stage-specific mRNA expression changes in Parkinson's disease.		circHSH2D	hsa_circ_HSH2D	HSH2D	Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	up-regulated	RNA-seq	"circHSH2D is a computationally identified, uniquely expressed up-regulated circRNA in PD across stages (reported as stage-specific), proposed as part of predicted ceRNA networks from whole-blood PPMI RNA-seq data, without experimental validation."	0.1768
41328340	Theranostics	2026	PTBP1-mediated inhibition of circular RNA SCMH1 biogenesis impairs brain recovery after ischemic stroke.		circSCMH1	mmu_circ_Scmh1	Scmh1	ischemic stroke / IS	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR; RNA-seq	"In ischemic stroke models, circSCMH1 is down-regulated in peri-infarct brain regions. PTBP1 binds the circSCMH1 precursor at the downstream intronic 800_882 segment (via its RRM4 domain) to inhibit back-splicing, reducing circSCMH1 biogenesis; restoring circSCMH1 (or suppressing PTBP1) mitigates astrocyte activation and improves functional recovery."	0.6996
41328768	Thoracic cancer	2025	Fucosyltransferase 8-Derived Circular RNA Drives M2 Polarization of Macrophages Through ENO1-TNF Signaling Axis to Promote Lung Cancer Progression.	hsa_circ_0003028	CircFUT8 / circ_0003028	hsa_circ_FUT8	FUT8	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; Microarray	"circFUT8 (hsa_circ_0003028), derived from FUT8, is upregulated in lung cancer/NSCLC tissues and associates with advanced stage and poor overall survival. Functionally, it promotes tumor cell proliferation, migration and invasion while inhibiting apoptosis, and it drives an immunosuppressive microenvironment by promoting M2 macrophage polarization. Mechanistically, circFUT8 binds the RBP ENO1 in the cytoplasm, enhancing glycolysis/lactate production to activate TNF signaling and downstream genes (e.g., JUN, CSF1/CSF2, CCL5, MMP9)."	0.8469
41330006	Translational oncology	2026	Circular RNA circAHSA1 serves as a stable serum biomarker for the diagnosis and progression of gastric cancer.	hsa_circ_0032777	circAHSA1	hsa_circ_AHSA1	AHSA1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circAHSA1 (hsa_circ_0032777), derived from AHSA1, is up-regulated in gastric cancer tissues, serum, and GC cell lines. It promotes malignant phenotypes (proliferation, migration, invasion) and inhibits apoptosis with effects on cell-cycle distribution. It is mainly cytoplasmic and is predicted (bioinformatically) to interact with miR-647 and miR-661, and it shows diagnostic utility in serum (ROC/AUC) and association with clinicopathologic features."	0.8226
41340258	Thoracic research and practice	2025	Expression Profile of circRNA in Lung Cancer Cells Infected with Staphylococcus aureus.	hsa_circ_0000003				lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	"RT-qPCR showed hsa_circ_0000003 was significantly down-regulated in A549 lung cancer cells and Beas-2B cells after S. aureus infection, suggesting a potential regulatory role in infection response."	0.1768
41340258	Thoracic research and practice	2025	Expression Profile of circRNA in Lung Cancer Cells Infected with Staphylococcus aureus.	hsa_circ_0043278				lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	"hsa_circ_0043278 was significantly down-regulated after S. aureus infection in both A549 and Beas-2B cells, and was proposed to have a potential regulatory role in the infection response."	0.1768
41340258	Thoracic research and practice	2025	Expression Profile of circRNA in Lung Cancer Cells Infected with Staphylococcus aureus.	hsa_circ_0005320				lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	hsa_circ_0005320 decreased significantly in A549 and Beas-2B cells after S. aureus infection and was suggested to potentially participate in infection response regulation.	0.1768
41340258	Thoracic research and practice	2025	Expression Profile of circRNA in Lung Cancer Cells Infected with Staphylococcus aureus.	hsa_circ_0001421				lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	hsa_circ_0001421 was significantly down-regulated in A549 and Beas-2B cells following S. aureus infection and may be involved in host infection-response regulation.	0.1768
41340258	Thoracic research and practice	2025	Expression Profile of circRNA in Lung Cancer Cells Infected with Staphylococcus aureus.	hsa_circ_0003998				lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	"hsa_circ_0003998 was significantly reduced in A549 and Beas-2B cells after S. aureus infection, indicating potential involvement in infection-response regulation."	0.1768
41340258	Thoracic research and practice	2025	Expression Profile of circRNA in Lung Cancer Cells Infected with Staphylococcus aureus.	hsa_circ_0056285				lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	"hsa_circ_0056285 was significantly down-regulated in both A549 and Beas-2B cells upon S. aureus infection, implying a potential role in infection response."	0.1768
41340258	Thoracic research and practice	2025	Expression Profile of circRNA in Lung Cancer Cells Infected with Staphylococcus aureus.	hsa_circ_0001821				lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	"hsa_circ_0001821 was significantly down-regulated after S. aureus infection in A549 and Beas-2B cells, and was implicated as a potential regulator in infection response."	0.1768
41340258	Thoracic research and practice	2025	Expression Profile of circRNA in Lung Cancer Cells Infected with Staphylococcus aureus.	hsa_circ_0077837				lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	"hsa_circ_0077837 was significantly down-regulated in A549 and Beas-2B cells after S. aureus infection, suggesting a potential role in infection response."	0.1768
41340258	Thoracic research and practice	2025	Expression Profile of circRNA in Lung Cancer Cells Infected with Staphylococcus aureus.	hsa_circ_0000326				lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	hsa_circ_0000326 was significantly down-regulated in A549 and Beas-2B cells after S. aureus infection and was suggested to have potential regulatory roles in infection response.	0.1768
41347180	Frontiers in pharmacology	2025	"Six-methoxyflavone suppresses CircPIAS1 biogenesis via targeting PTBP1 and, in combination with IFN-gamma, promotes ferroptosis in melanoma."	hsa_circ_0008378	CircPIAS1	hsa_circ_PIAS1	PIAS1	melanoma	MONDO:0005105	melanoma	unknown	RT-qPCR	"In melanoma, circPIAS1 is an oncogenic circRNA (via circPIAS1-108aa) that suppresses STAT1 phosphorylation and supports the SLC7A11/GPX4 program to limit immunogenic ferroptosis. This study shows that 6-methoxyflavone inhibits PTBP1 to suppress circPIAS1 biogenesis, and with IFN-gamma enhances ferroptosis-related oxidative stress and antitumor effects."	0.6093
41350865	Molecular cancer	2025	CircRNF10 sequestrates beta-catenin by a dual regulatory circuit of direct degradation and a miR-1275/DKK3-mediated inhibition in driver gene- negative lung adenocarcinoma.	hsa_circ_0028912	circRNF10	hsa_circ_RNF10	RNF10	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; ISH; Microarray	"circRNF10 is down-regulated in driver gene-negative LUAD and acts as a tumor suppressor. It inhibits Wnt/beta-catenin signaling by directly binding beta-catenin to promote its degradation and by sponging miR-1275 to relieve repression of DKK3, thereby reducing proliferation, migration, invasion, and metastasis and associating with better patient survival."	0.8901
41351065	Cellular & molecular biology letters	2025	The novel circular RNA circG6pc attenuates oxidative stress and mitochondrial damage through miR-7018-5p/Aldh6a1 axis in kidney fibrosis.	hsa_circ_0043917	circG6pc / mmu-circG6pc	hsa_circ_G6pc	G6pc	kidney fibrosis / renal fibrosis	MONDO:0000494	renal fibrosis	down-regulated	RT-qPCR; ISH; RNA-seq	"circG6pc is down-regulated in fibrotic kidneys (UUO model and obstructive hydronephrosis clinical samples). It protects against renal fibrosis by acting as a ceRNA that sponges miR-7018-5p and de-represses Aldh6a1, thereby improving mitochondrial biogenesis/dynamics and reducing oxidative stress."	0.8817
41351065	Cellular & molecular biology letters	2025	The novel circular RNA circG6pc attenuates oxidative stress and mitochondrial damage through miR-7018-5p/Aldh6a1 axis in kidney fibrosis.		circG6pc / mmu-circG6pc	mmu_circ_G6pc	G6pc	kidney fibrosis / renal fibrosis	MONDO:0000494	renal fibrosis	down-regulated	RT-qPCR; ISH; RNA-seq	"circG6pc is down-regulated in fibrotic kidneys (UUO model and obstructive hydronephrosis clinical samples). It protects against renal fibrosis by acting as a ceRNA that sponges miR-7018-5p and de-represses Aldh6a1, thereby improving mitochondrial biogenesis/dynamics and reducing oxidative stress."	0.8817
41356416	Materials today. Bio	2025	Macrophage targeted cellular microparticles synergize anti-tuberculosis therapy combining CircRNA-mediated host immune defense and antibiotic killing.		CircRNA TRAPPC6B / circTRAPPC6B	hsa_circ_TRAPPC6B	TRAPPC6B	Tuberculosis / TB	MONDO:0018076	tuberculosis	unknown	RT-qPCR	"circTRAPPC6B is used as an immunomodulatory therapeutic circRNA cargo delivered to macrophages via galactose-targeted microparticles. Increasing intracellular circTRAPPC6B enhances host antibacterial defenses (autophagy and M1 polarization, and associated apoptosis), in part through inhibition of PI3K/AKT/mTOR signaling, thereby improving intracellular mycobacterial clearance and reducing lung bacterial burden and pathology in infected mice."	0.4249
41358261	Breast cancer (Dove Medical Press)	2025	Circular RNA DENND4C Regulates Cell Malignant Behaviors in Breast Cancer Through the miR-26a-5p/HSPA8 Axis.		circDENND4C	hsa_circ_DENND4C	DENND4C	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circDENND4C is upregulated in breast cancer and functions as an oncogenic circRNA. It sponges miR-26a-5p to increase HSPA8, thereby promoting proliferation, cell-cycle progression, migration and invasion, and its high expression correlates with worse survival."	0.8001
41359154	Cellular and molecular life sciences : CMLS	2025	CircEPHB4 binds to YBX1 to upregulate MRPS16 and promotes glioma progression.		circEPHB4	hsa_circ_EPHB4	EPHB4	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circEPHB4 is up-regulated in glioma and promotes proliferation, migration and invasion. Mechanistically, it binds YBX1 to prevent RBBP6-mediated ubiquitination and degradation of YBX1, thereby stabilizing YBX1 and enhancing MRPS16 mRNA stability via YBX1-dependent m5C modification, which drives glioma progression in vitro and in xenograft models."	0.8703
41360764	Cell death discovery	2025	CircPPFIA2 drives prostate cancer progression and enzalutamide resistance by sponging miR-646 and miR-1200 to upregulate ETS1.	hsa_circ_00099343	circPPFIA2	hsa_circ_PPFIA2	PPFIA2	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; ISH	"circPPFIA2 is up-regulated in prostate cancer and promotes proliferation, migration/metastasis, EMT activation, and anti-apoptotic behavior. It functions mainly as a cytoplasmic ceRNA that sponges miR-646 and miR-1200, thereby upregulating ETS1 and driving enzalutamide resistance."	0.8933
41361160	Discover oncology	2025	Investigating the expression of hsa_circ_0036722/hsa-miR-503-5p/PDCD4 axis in esophageal cancer.	hsa_circ_0036722		hsa_circ_RHCG	RHCG	esophageal cancer / EC	MONDO:0007576	esophageal cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0036722 is significantly down-regulated in esophageal cancer (ESCC) tissues. The study proposes a tumor-suppressor ceRNA axis in which hsa_circ_0036722 is inversely correlated with hsa-miR-503-5p and positively correlated with PDCD4, and suggests diagnostic potential based on ROC analysis."	0.5047
41362724	International journal of biological sciences	2026	Circular RNA circPLXNC1 functions as an inhibitor of senescence by regulating autophagy in osteoarthritis.	hsa_circ_0099504	circPLXNC1	hsa_circ_PLXNC1	PLXNC1	osteoarthritis / OA	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR; ISH; RNA-seq	circPLXNC1 is down-regulated in osteoarthritis cartilage and age-associated tissues. It inhibits chondrocyte senescence and OA progression by promoting autophagy via a ceRNA axis where circPLXNC1 sponges miR-130b-5p to increase ATG7; FUS contributes to circPLXNC1 biogenesis.	0.8326
41362724	International journal of biological sciences	2026	Circular RNA circPLXNC1 functions as an inhibitor of senescence by regulating autophagy in osteoarthritis.		circPLXNC1	mmu_circ_PLXNC1	PLXNC1	osteoarthritis / OA	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR; ISH; RNA-seq	circPLXNC1 is down-regulated in osteoarthritis cartilage and age-associated tissues. It inhibits chondrocyte senescence and OA progression by promoting autophagy via a ceRNA axis where circPLXNC1 sponges miR-130b-5p to increase ATG7; FUS contributes to circPLXNC1 biogenesis.	0.8326
41372808	Cellular & molecular biology letters	2025	Ribosomal protein RPL7A modulates lung adenocarcinoma progression via circRANBP17-UPF1-mediated SIRT6 degradation.		circRNA12063 / circRANBP17	hsa_circ_RANBP17	RANBP17	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circRANBP17 is up-regulated in LUAD cells and promotes migration/invasion/proliferation and tumor growth. Mechanistically, it binds UPF1 and recruits SIRT6 mRNA to enhance NMD-mediated degradation, reducing SIRT6 and thereby supporting lipogenesis/lipid metabolism and metastasis."	0.8201
41372977	World journal of surgical oncology	2025	Circ_0001741 regulates proliferation and invasion in ESCC via the miR-194-5p/E2F3 axis.	hsa_circ_0001741	circ_0001741	hsa_circ_TNPO3	TNPO3	Esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"circ_0001741 is upregulated in ESCC tissues and promotes malignant phenotypes by enhancing proliferation and invasion. It functions as a ceRNA that sponges miR-194-5p, thereby relieving repression of E2F3 and forming a circ_0001741/miR-194-5p/E2F3 axis validated by luciferase, pull-down and rescue experiments."	0.8154
41382223	Molecular cancer	2025	CircZFAND6 suppresses gastric cancer metastasis and reduces resistance to TKI therapy.	hsa_circ_0000643	Circ_0000643 / circZFAND6	hsa_circ_ZFAND6	ZFAND6	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; RNA-seq; Microarray	"circZFAND6 is down-regulated in gastric cancer and peritoneal dissemination and functions as a tumor suppressor. It sponges miR-6815-3p to upregulate APC and inactivate Wnt/beta-catenin signaling, inhibiting proliferation and metastasis/EMT. In addition, circZFAND6 undergoes rolling translation to produce circZFAND6-aa that binds ERBB3 and dampens EGFR-driven PI3K/AKT signaling, improving gefitinib sensitivity and reducing gefitinib resistance."	0.8769
41391036	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2026	Circular RNA PTPN4 Contributes to Blood-Brain Barrier Disruption during Early Epileptogenesis.	mmu_circ_0000069	CircPTPN4 / Circ_0 004696	mmu_circ_PTPN4	PTPN4	epilepsy	MONDO:0005027	epilepsy	up-regulated	RT-qPCR; RNA-seq	"In a pilocarpine-induced mouse TLE model, CircPTPN4 is up-regulated in brain endothelium and plasma during early epileptogenesis. CircPTPN4 acts as a cytoplasmic ceRNA that sponges miR-145a-5p to de-repress ECE-1, increasing ET-1 production and activating p38/MAPK, which suppresses tight junction proteins and disrupts BBB integrity; CircPTPN4 knockdown improves BBB function and reduces spontaneous seizure frequency."	0.8088
41391768	The Journal of biological chemistry	2026	CircAMOTL1 promotes adipose lipolysis and browning in cancer cachexia through miR-211-5p-mediated TET2 activation.	hsa_circ_0000350	circAMOTL1 / hsa_AMOTL1_0000900	hsa_circ_AMOTL1	AMOTL1	cancer	MONDO:0004992	cancer	up-regulated	RT-qPCR; RNA-seq	"circAMOTL1 (hsa_circ_0000350) is up-regulated in subcutaneous adipose tissue of cachectic cancer patients and correlates with weight loss severity. It promotes adipocyte lipolysis and WAT browning by sponging miR-211-5p, which relieves repression of TET2, and it exacerbates adipose wasting in a C26 tumor-bearing mouse cachexia model. It also shows diagnostic value (ROC) and high expression is associated with worse overall survival."	0.8846
41391768	The Journal of biological chemistry	2026	CircAMOTL1 promotes adipose lipolysis and browning in cancer cachexia through miR-211-5p-mediated TET2 activation.	hsa_circ_0000350	circAMOTL1 / hsa_AMOTL1_0000900	hsa_circ_AMOTL1	AMOTL1	cancer cachexia	MONDO:0004992	cancer	up-regulated	RT-qPCR; RNA-seq	"circAMOTL1 (hsa_circ_0000350) is up-regulated in subcutaneous adipose tissue of cachectic cancer patients and correlates with weight loss severity. It promotes adipocyte lipolysis and WAT browning by sponging miR-211-5p, which relieves repression of TET2, and it exacerbates adipose wasting in a C26 tumor-bearing mouse cachexia model. It also shows diagnostic value (ROC) and high expression is associated with worse overall survival."	0.8846
41392243	World journal of surgical oncology	2025	Integrated molecular subtyping and functional analysis of circ_0001946/miR-7-5p axis reveals a glucose metabolism-linked regulatory mechanism in ovarian cancer.	hsa_circ_0001946				ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circ_0001946 is up-regulated in ovarian cancer and functions as an oncogenic circRNA by directly binding (sponging) miR-7-5p. Its overexpression promotes proliferation, reduces apoptosis, and enhances xenograft tumor growth, supporting a miRNA-sponge (ceRNA-like) mechanism."	0.6542
41398363	Scientific reports	2025	Identification of competing endogenous RNA networks involved in phrenic nerve stimulation preventing mechanical ventilation induced diaphragm dysfunction.		circRNA_12437			ventilator-induced diaphragmatic dysfunction / VIDD	MONDO:0005728	diaphragm disorder	dysregulated	RT-qPCR; RNA-seq	"circRNA_12437 is a rabbit diaphragm circRNA dysregulated by mechanical ventilation and partly reversed by phrenic nerve stimulation. It is proposed (computational prediction with RT-qPCR-supported expression trends, but without direct binding validation) to act as a ceRNA sponge for miR-500-3p and/or miR-133b-3p, thereby influencing the RAB37-autophagy and L-selectin-immune infiltration/fibrosis-related axes in VIDD."	0.5922
41398363	Scientific reports	2025	Identification of competing endogenous RNA networks involved in phrenic nerve stimulation preventing mechanical ventilation induced diaphragm dysfunction.		circRNA_24673			ventilator-induced diaphragmatic dysfunction / VIDD	MONDO:0005728	diaphragm disorder	dysregulated	RT-qPCR; RNA-seq	"circRNA_24673 is dysregulated in rabbit diaphragm under mechanical ventilation and is among five circRNAs validated by RT-qPCR for expression trends. It is predicted to sponge miR-500-3p within a proposed ceRNA framework impacting the RAB37/autophagy-related axis in VIDD, but the circRNA-miRNA binding was not experimentally validated."	0.5922
41398363	Scientific reports	2025	Identification of competing endogenous RNA networks involved in phrenic nerve stimulation preventing mechanical ventilation induced diaphragm dysfunction.		circRNA_14127			ventilator-induced diaphragmatic dysfunction / VIDD	MONDO:0005728	diaphragm disorder	dysregulated	RT-qPCR; RNA-seq	"circRNA_14127 is dysregulated in rabbit diaphragm under mechanical ventilation and is among five circRNAs with RT-qPCR-validated expression trends. It is predicted to sponge miR-500-3p in a proposed ceRNA network linked to RAB37/autophagy regulation in VIDD, but direct circRNA-miRNA interaction was not experimentally validated."	0.5922
41398363	Scientific reports	2025	Identification of competing endogenous RNA networks involved in phrenic nerve stimulation preventing mechanical ventilation induced diaphragm dysfunction.		circRNA_14942			ventilator-induced diaphragmatic dysfunction / VIDD	MONDO:0005728	diaphragm disorder	dysregulated	RT-qPCR; RNA-seq	"circRNA_14942 is among the five circRNAs with RT-qPCR-supported expression trends in rabbit diaphragm affected by mechanical ventilation and phrenic nerve stimulation. It is hypothesized to act as a miRNA sponge within the proposed ceRNA network influencing autophagy and immune-related responses in VIDD, but direct circRNA-miRNA binding could not be experimentally validated."	0.5922
41398363	Scientific reports	2025	Identification of competing endogenous RNA networks involved in phrenic nerve stimulation preventing mechanical ventilation induced diaphragm dysfunction.		circRNA_12463			ventilator-induced diaphragmatic dysfunction / VIDD	MONDO:0005728	diaphragm disorder	dysregulated	RT-qPCR; RNA-seq	"circRNA_12463 is a rabbit diaphragm circRNA dysregulated by mechanical ventilation and partly reversed by phrenic nerve stimulation, with expression trends supported by RT-qPCR among five circRNAs. It is computationally predicted to sponge miR-133b-3p in a ceRNA network connected to the L-selectin axis (immune cell recruitment/fibrosis-related), but the circRNA-miRNA binding could not be directly validated."	0.5922
41398523	Human cell	2025	Hsa_circ_0000437 promotes the progression of rheumatic valvular heart disease by activating the mitogen-activated protein kinase signaling pathways after sponging let-7f-5p and targeting RAS-like proto-oncogene B.	hsa_circ_0000437				rheumatic valvular heart disease / RVHD	MONDO:0006955	rheumatic heart disease	up-regulated	Microarray	"In RVHD, hsa_circ_0000437 is up-regulated in patient plasma and functions as a pro-disease circRNA. It sponges let-7f-5p and targets/binds RALB to activate MAPK signaling, thereby promoting hVIC proliferation/migration/cell-cycle progression and inhibiting apoptosis. It also shows strong diagnostic potential (especially combined with let-7f-5p)."	0.7834
41398660	BMC cancer	2025	Engineered hUCMSC-derived extracellular vesicles deliver circ-0000258 to restore p53-mediated tumor suppression in papillary thyroid carcinoma.	hsa_circ_0000258				papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR; RNA-seq	"circ-0000258 is downregulated in papillary thyroid carcinoma and functions as a tumor suppressor. It sponges miR-146b to relieve repression of TP53/p53, activating p53-mediated apoptosis and inhibiting malignant behaviors; engineered hUCMSC-derived extracellular vesicles delivering circ-0000258 suppress xenograft tumor growth and synergize with cisplatin."	0.7761
41398660	BMC cancer	2025	Engineered hUCMSC-derived extracellular vesicles deliver circ-0000258 to restore p53-mediated tumor suppression in papillary thyroid carcinoma.		hsa-circ-000932			papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR	hsa-circ-000932 is reported as significantly downregulated in PTC tissues versus adjacent normal thyroid tissues based on qPCR; no functional or mechanistic validation for this circRNA is described beyond expression change.	0.2995
41401631	Translational oncology	2026	Circular RNA circSCMH1 regulates glycolysis to inhibit gastric cancer metastasis via miR-296-3p/HSPB7-GLUT3 axis.	hsa_circ_0000061		hsa_circ_SCMH1	SCMH1	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; RNA-seq	"circSCMH1 is down-regulated in high-metastasis gastric cancer and suppresses GC proliferation and metastasis. Mechanistically, it sponges miR-296_3p to upregulate HSPB7, which promotes GLUT3 ubiquitination/degradation, inhibits glycolysis, and attenuates EMT-related malignant phenotypes. Clinically, low circSCMH1 is associated with lymph node metastasis and worse overall survival."	0.8942
41403754	Journal of molecular and cellular cardiology plus	2025	Identification of circular RNA hsa-PHACTR4_0009 as a new class of biomarker for transposition of the great arteries.		hsa-PHACTR4_0009 / circ-PHACTR4	hsa_circ_PHACTR4	PHACTR4	Dextro-Transposition of great arteries / d-TGA	MONDO:0019443	dextro-looped transposition of the great arteries	up-regulated	RT-qPCR; RNA-seq	"hsa-PHACTR4_0009 is up-regulated in the plasma of neonates with d-TGA and shows good diagnostic performance (ROC AUC 0.900), with higher levels in more severe cases. Functional assays indicate that hsa-PHACTR4_0009 overexpression promotes cardiomyocyte migration and is associated with dysregulation of focal-adhesion/cytoskeletal migration programs, suggesting a role in abnormal migration processes contributing to d-TGA."	0.7474
41411370	PLoS genetics	2025	"Circular RNA profiling revealed an evolutionarily conserved circACACA promotes liver lipid metabolism, oxidative stress, and autophagy disorder in a ceRNA manner."		circACACA	gga_circ_ACACA	ACACA	non-alcoholic fatty liver disease / NAFLD	MONDO:0013209	metabolic dysfunction-associated steatotic liver disease	up-regulated	RT-qPCR; RNA-seq	"In chicken fatty liver syndrome (FLS, NAFLD-like), circACACA is up-regulated in liver and mainly cytoplasmic, where it acts as a ceRNA sponging miR-132b-5p and miR-101-2-5p. Through relieving repression of CBFB and impacting the CBFB/PIM1 complex, it attenuates AKT/mTOR and PPAR-gamma signaling, promoting lipid accumulation, oxidative stress and autophagy, thereby impairing liver health."	0.7446
41411370	PLoS genetics	2025	"Circular RNA profiling revealed an evolutionarily conserved circACACA promotes liver lipid metabolism, oxidative stress, and autophagy disorder in a ceRNA manner."		mmu-circAcaca	mmu_circ_Acaca	Acaca	non-alcoholic fatty liver disease / NAFLD	MONDO:0013209	metabolic dysfunction-associated steatotic liver disease	up-regulated	RT-qPCR	"In a high-fat diet mouse fatty liver model, mmu-circAcaca is up-regulated in liver and localizes to both nucleus and cytoplasm (mainly cytoplasm). Functional modulation in AML12 cells indicates it promotes lipid accumulation, increases oxidative stress (ROS/MDA) and enhances autophagy, supporting functional conservation with chicken circACACA."	0.6634
41411856	Poultry science	2026	Comprehensive transcriptome profiling of the chicken bursa infected with the novel variant infectious bursal disease virus.		circRNA_2331			infectious bursal disease / IBD 	MONDO:0005108	viral infectious disease	up-regulated	RT-qPCR; RNA-seq	circRNA_2331 is up-regulated in chicken bursa of Fabricius at 7 dpi after nVarIBDV infection (RNA-seq and RT-qPCR validated). The study does not provide circRNA_2331-specific downstream miRNA/mRNA targets or functional assays; circRNA functions are discussed mainly at the network/prediction level.	0.1904
41411856	Poultry science	2026	Comprehensive transcriptome profiling of the chicken bursa infected with the novel variant infectious bursal disease virus.		circRNA_2350			infectious bursal disease / IBD 	MONDO:0005108	viral infectious disease	up-regulated	RT-qPCR; RNA-seq	circRNA_2350 is up-regulated in chicken bursa of Fabricius at 7 dpi after nVarIBDV infection (RNA-seq and RT-qPCR validated). The study does not report circRNA_2350-specific miRNA/mRNA targets or functional experiments; circRNA roles are primarily inferred from predicted ceRNA networks.	0.1904
41411856	Poultry science	2026	Comprehensive transcriptome profiling of the chicken bursa infected with the novel variant infectious bursal disease virus.		circRNA_1316			infectious bursal disease / IBD 	MONDO:0005108	viral infectious disease	down-regulated	RT-qPCR; RNA-seq	circRNA_1316 is down-regulated in chicken bursa of Fabricius at 7 dpi following nVarIBDV infection (RNA-seq and RT-qPCR validated). No circRNA_1316-specific miRNA/mRNA interactions or functional phenotypes are experimentally confirmed in this paper.	0.1904
41411856	Poultry science	2026	Comprehensive transcriptome profiling of the chicken bursa infected with the novel variant infectious bursal disease virus.		circRNA_3117			infectious bursal disease / IBD 	MONDO:0005108	viral infectious disease	down-regulated	RT-qPCR; RNA-seq	circRNA_3117 is down-regulated in chicken bursa of Fabricius at 7 dpi following nVarIBDV infection (RNA-seq and RT-qPCR validated). The paper does not provide circRNA_3117-specific validated targets or functional experiments beyond expression validation.	0.1904
41411856	Poultry science	2026	Comprehensive transcriptome profiling of the chicken bursa infected with the novel variant infectious bursal disease virus.		circRNA_1621			infectious bursal disease / IBD 	MONDO:0005108	viral infectious disease	down-regulated	RT-qPCR; RNA-seq	circRNA_1621 is down-regulated in chicken bursa of Fabricius at 7 dpi following nVarIBDV infection (RNA-seq and RT-qPCR validated). The study does not experimentally validate circRNA_1621-specific ceRNA interactions or biological effects.	0.1904
41416079	Frontiers in medicine	2025	Exercise-responsive circTSN as a potential systemic biomarker during COPD rehabilitation.	hsa_circ_0003789	circTSN	hsa_circ_TSN	TSN	Chronic Obstructive Pulmonary Disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR; RNA-seq	"In COPD rehabilitation, circTSN increases after exercise training and is inversely associated with systemic inflammatory markers. It localizes mainly in the cytoplasm and acts as a ceRNA by sponging miR-144-3p to de-repress GATA6, thereby modulating inflammatory gene expression in airway epithelial cells and supporting its utility as a systemic biomarker of exercise-induced adaptation."	0.7693
41417426	Discover oncology	2025	CircRNA CeRNA networks in gastric cancer highlight FAP/FNDC1 as potential prognostic and therapeutic targets.	hsa_circ_0055521				gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	Microarray	"This study bioinformatically identified hsa_circ_0055521 as part of a prognosis-related ceRNA axis in gastric cancer, potentially sponging hsa-miR-204-5p to regulate FAP. The circRNA was inferred to be upregulated in tumor versus adjacent normal tissues based on the DEcircRNA pattern in the analyzed GEO dataset."	0.1768
41417426	Discover oncology	2025	CircRNA CeRNA networks in gastric cancer highlight FAP/FNDC1 as potential prognostic and therapeutic targets.	hsa_circ_0005051				gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	Microarray	"This study identified hsa_circ_0005051 as one component of a prognosis-related ceRNA network in gastric cancer, proposed to sponge hsa-miR-32-3p and thereby regulate FNDC1. The evidence is based on GEO/TCGA integrative bioinformatics analyses without wet-lab validation for the circRNA."	0.1768
41417426	Discover oncology	2025	CircRNA CeRNA networks in gastric cancer highlight FAP/FNDC1 as potential prognostic and therapeutic targets.	hsa_circ_0007613				gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	Microarray	"This study proposed hsa_circ_0007613 as part of a prognostic ceRNA network in gastric cancer, potentially sponging hsa-miR-32-3p to affect FNDC1. The association is supported by integrated GEO/TCGA bioinformatics analyses without circRNA experimental validation."	0.1768
41417426	Discover oncology	2025	CircRNA CeRNA networks in gastric cancer highlight FAP/FNDC1 as potential prognostic and therapeutic targets.	hsa_circ_0045602				gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	Microarray	"This study proposed hsa_circ_0045602 as part of a FNDC1-centered prognostic ceRNA axis in gastric cancer via sponging hsa-miR-32-3p. Evidence is computational, derived from GEO/TCGA integration and network inference."	0.1768
41417426	Discover oncology	2025	CircRNA CeRNA networks in gastric cancer highlight FAP/FNDC1 as potential prognostic and therapeutic targets.	hsa_circ_0034398				gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	Microarray	"This study proposed hsa_circ_0034398 as one of five circRNAs forming a prognostic ceRNA network in gastric cancer, potentially acting as a sponge for hsa-miR-32-3p to regulate FNDC1. The evidence is derived from bioinformatics network construction and database analyses."	0.1768
41417426	Discover oncology	2025	CircRNA CeRNA networks in gastric cancer highlight FAP/FNDC1 as potential prognostic and therapeutic targets.	hsa_circ_0006089				gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	Microarray	"This study proposed hsa_circ_0006089 as part of a FNDC1 prognostic ceRNA axis in gastric cancer via sponging hsa-miR-32-3p. The work is computational, relying on GEO differential expression and ceRNA network construction with TCGA survival integration."	0.1768
41426249	Journal of inflammation research	2025	Uncovering Circular RNA Signatures in Rheumatoid Arthritis: Novel Biomarkers and Clinical Implications.	hsa_circ_0001394		hsa_circ_TBC1D14	TBC1D14	rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001394 is up-regulated in PBMCs from RA patients and shows strong diagnostic value, with reported perfect sensitivity for distinguishing RA from healthy controls. No RA-specific downstream mechanism was experimentally validated in this study."	0.5047
41426249	Journal of inflammation research	2025	Uncovering Circular RNA Signatures in Rheumatoid Arthritis: Novel Biomarkers and Clinical Implications.	hsa_circ_0001998				rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001998 is up-regulated in RA PBMCs and shows excellent diagnostic performance with reported perfect specificity. Its expression is positively correlated with rheumatoid factor levels, supporting clinical relevance."	0.4679
41426249	Journal of inflammation research	2025	Uncovering Circular RNA Signatures in Rheumatoid Arthritis: Novel Biomarkers and Clinical Implications.	hsa_circ_0009172		hsa_circ_DNA2	DNA2	rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0009172 (derived from DNA2) is up-regulated in RA PBMCs and has diagnostic potential. Clinically, higher levels are associated with lower anti-CCP antibody titers; no direct downstream mechanism was validated in RA in this paper."	0.4679
41426249	Journal of inflammation research	2025	Uncovering Circular RNA Signatures in Rheumatoid Arthritis: Novel Biomarkers and Clinical Implications.	hsa_circ_0006732				rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0006732 is up-regulated in RA PBMCs and provides diagnostic value by ROC analysis. This study did not experimentally define a specific RA-related molecular mechanism for hsa_circ_0006732.	0.4679
41426249	Journal of inflammation research	2025	Uncovering Circular RNA Signatures in Rheumatoid Arthritis: Novel Biomarkers and Clinical Implications.		circRNA2842	hsa_circ_PSTPIP2	PSTPIP2	rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; RNA-seq	circRNA2842 (from PSTPIP2) is up-regulated in RA PBMCs and shows modest diagnostic performance. The paper provides no experimentally validated mechanism for circRNA2842 in RA.	0.4679
41426249	Journal of inflammation research	2025	Uncovering Circular RNA Signatures in Rheumatoid Arthritis: Novel Biomarkers and Clinical Implications.		circRNA8330	hsa_circ_NLRP12	NLRP12	rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; RNA-seq	circRNA8330 (from NLRP12) is up-regulated in RA PBMCs and shows diagnostic value by ROC analysis. The study did not experimentally validate a specific mechanistic pathway for circRNA8330 in RA.	0.4679
41439029	Non-coding RNA research	2026	The regulatory role of circGDI2 in hepatocellular carcinoma proliferation and glycolysis with the involvement of m6A modification.	hsa_circ_0005379	circGDI2 / circ_0005379	hsa_circ_GDI2	GDI2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circGDI2 is up-regulated in hepatocellular carcinoma tissues and cell lines and mainly localizes to the cytoplasm. It promotes HCC proliferation, glycolysis, and tumor growth by interacting with the m6A reader IGF2BP2 to enhance PKM2 expression/stability, while FTO-dependent m6A modification increases circGDI2 stability and expression, reinforcing the circGDI2_IGF2BP2_PKM2 axis."	0.817
41446787	Frontiers in pharmacology	2025	DICAR/DICAR-JP exerts therapeutic effects in brain stroke via the miR-361-5p/PRMT1 pathway.		DICAR / Circular RNA-DICAR			ischemic stroke / IS	MONDO:1060198	ischemic stroke	dysregulated	RT-qPCR	"In mouse cerebral ischemia/reperfusion (stroke) models, DICAR alleviates brain injury and improves neurological outcomes by promoting angiogenesis and vascular remodeling. Mechanistically, it modulates the miR-361-5p/PRMT1 axis to support endothelial angiogenic function."	0.6521
41449260	Cellular and molecular life sciences : CMLS	2025	Bone marrow mesenchymal stem cell-derived circHECTD1 targets claudin1 through the CTCF/METTL3 axis to alleviate ulcerative colitis : Short title: BMSC-derived circHECTD1 alleviates UC.		circHECTD1 / Exo-circHECTD1	mmu_circ_HECTD1	HECTD1	ulcerative colitis / UC	MONDO:0005101	ulcerative colitis	down-regulated	RT-qPCR	"BMSC-derived exosomal circHECTD1 protects intestinal epithelial cells and alleviates DSS-induced ulcerative colitis. Mechanistically, circHECTD1 binds the transcription factor CTCF, suppressing METTL3 transcription, reducing m6A modification on claudin1 mRNA, and thereby increasing claudin1 expression to improve barrier function and inflammatory/immune imbalance."	0.6711
41459113	Genes & diseases	2026	"circFKBP8(5S,6)-encoded protein promotes stress susceptibility in mice by down-regulating dopamine D3 receptor expression and its downstream AMPK/mTOR/ULK1 autophagy signaling."		"circFKBP8(5S,6)"	hsa_circ_FKBP8	FKBP8	major depressive disorder / MDD	MONDO:0002009	major depressive disorder	unknown	RNA-seq	"In a mouse CUMS model, circFKBP8(5S,6) promotes stress susceptibility via its encoded protein cFKBP8. Mechanistically, it reduces DRD3 expression and suppresses DRD3-associated AMPK/mTOR/ULK1 signaling, leading to decreased neuronal autophagy in the prelimbic cortex."	0.4852
41462040	Scientific reports	2025	"Circ005699 regulates ox-LDL-induced vascular endothelial cell proliferation, autophagy and inflammation by sponging miR-636 and interacting with FTO."	hsa_circ_0005699	circ0005699 / circ_0005699	hsa_circ_C16orf62	C16orf62	atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR; RNA-seq; Microarray	"circ0005699 is upregulated in atherosclerosis (patient serum and ox-LDL_treated endothelial cells). It suppresses endothelial proliferation/angiogenesis and autophagy by sponging miR-636 to increase SLC7A5 and activate mTORC1 signaling, and it promotes inflammation by binding FTO to reduce m6A on EGR1 mRNA and stabilize EGR1."	0.8196
41462290	Journal of ovarian research	2025	Circular RNA circMYBL2 regulates the progression of ovarian cancer through miR-195-5P/BIRC5 axis.	hsa_circ_0060467	circMYBL2	hsa_circ_MYBL2	MYBL2	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; RNA-seq	"circMYBL2 (hsa_circ_0060467), derived from MYBL2, is upregulated in ovarian cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes ovarian cancer cell proliferation, migration and invasion, and enhances tumor growth and metastasis in vivo by sponging miR-195-5p to de-repress BIRC5 (Survivin) in a ceRNA axis. High circMYBL2 expression is associated with reduced overall survival in ovarian cancer patients."	0.8769
41463334	Biomolecules	2025	Molecular Network Analysis of HBV Persistent Infection from the Perspective of Whole Transcriptome.		circRNA4455			chronic HBV infection	MONDO:0005366	chronic hepatitis B virus infection	unknown	RNA-seq	circRNA4455 was identified as a significantly differential circRNA in the chronic HBV persistent infection mouse liver transcriptome and was highlighted as a potential candidate for further functional/mechanistic validation.	0.31
41463334	Biomolecules	2025	Molecular Network Analysis of HBV Persistent Infection from the Perspective of Whole Transcriptome.		circRNA4363			chronic HBV infection	MONDO:0005366	chronic hepatitis B virus infection	unknown	RNA-seq	circRNA4363 was identified as a significantly differential circRNA in the chronic HBV persistent infection mouse liver transcriptome and was highlighted as a potential candidate for further functional/mechanistic validation.	0.31
41463334	Biomolecules	2025	Molecular Network Analysis of HBV Persistent Infection from the Perspective of Whole Transcriptome.	mmu_circ_0001688				chronic HBV infection	MONDO:0005366	chronic hepatitis B virus infection	unknown	RNA-seq	mmu_circ_0001688 was identified as a significantly differential circRNA in the chronic HBV persistent infection mouse liver transcriptome and was highlighted as a potential candidate for further functional/mechanistic validation.	0.31
41463334	Biomolecules	2025	Molecular Network Analysis of HBV Persistent Infection from the Perspective of Whole Transcriptome.		circRNA1913			chronic HBV infection	MONDO:0005366	chronic hepatitis B virus infection	unknown	RNA-seq	"circRNA1913 was included in the circRNA_miRNA_mRNA ceRNA network and was predicted to competitively bind miR-185-3p to influence expression/translation of HBV-related target genes (Ctsd, Ikbkg, Nupr1, Per1, Ttbk1), thereby modulating host immune response in the chronic HBV infection mouse model."	0.31
41463334	Biomolecules	2025	Molecular Network Analysis of HBV Persistent Infection from the Perspective of Whole Transcriptome.		circRNA4430			chronic HBV infection	MONDO:0005366	chronic hepatitis B virus infection	unknown	RNA-seq	"circRNA4430 was included in the circRNA_miRNA_mRNA ceRNA network and was predicted to competitively bind miR-185-3p to influence HBV-related target genes (Ctsd, Ikbkg, Nupr1, Per1, Ttbk1) in the chronic HBV infection mouse model."	0.31
41463334	Biomolecules	2025	Molecular Network Analysis of HBV Persistent Infection from the Perspective of Whole Transcriptome.		circRNA4494			chronic HBV infection	MONDO:0005366	chronic hepatitis B virus infection	unknown	RNA-seq	"circRNA4494 was predicted in the ceRNA network to sponge miR-185-3p and thereby affect HBV-related downstream mRNAs (Ctsd, Ikbkg, Nupr1, Per1, Ttbk1), potentially influencing immune response in chronic HBV infection."	0.31
41463334	Biomolecules	2025	Molecular Network Analysis of HBV Persistent Infection from the Perspective of Whole Transcriptome.		circRNA8139			chronic HBV infection	MONDO:0005366	chronic hepatitis B virus infection	unknown	RNA-seq	"circRNA8139 was predicted in the ceRNA network to bind miR-185-3p and be linked to HBV-related downstream mRNAs (Ctsd, Ikbkg, Nupr1, Per1, Ttbk1) in the chronic HBV infection mouse liver transcriptome."	0.31
41463334	Biomolecules	2025	Molecular Network Analysis of HBV Persistent Infection from the Perspective of Whole Transcriptome.		circRNA8155			chronic HBV infection	MONDO:0005366	chronic hepatitis B virus infection	unknown	RNA-seq	"circRNA8155 was predicted to participate in a miR-185-3p-centered circRNA_miRNA_mRNA network in chronic HBV infection, potentially affecting HBV-related genes (Ctsd, Ikbkg, Nupr1, Per1, Ttbk1)."	0.31
41463334	Biomolecules	2025	Molecular Network Analysis of HBV Persistent Infection from the Perspective of Whole Transcriptome.		circRNA8741			chronic HBV infection	MONDO:0005366	chronic hepatitis B virus infection	unknown	RNA-seq	"circRNA8741 was predicted as a miR-185-3p-associated DEcircRNA in the ceRNA network, potentially regulating HBV-related target genes and influencing host immune response during chronic HBV infection."	0.31
41463334	Biomolecules	2025	Molecular Network Analysis of HBV Persistent Infection from the Perspective of Whole Transcriptome.		circRNA8743			chronic HBV infection	MONDO:0005366	chronic hepatitis B virus infection	unknown	RNA-seq	"circRNA8743 was predicted to act within a miR-185-3p-centered ceRNA network in chronic HBV infection, potentially affecting HBV-related target mRNAs and host immune response."	0.31
41463334	Biomolecules	2025	Molecular Network Analysis of HBV Persistent Infection from the Perspective of Whole Transcriptome.		circRNA9963			chronic HBV infection	MONDO:0005366	chronic hepatitis B virus infection	unknown	RNA-seq	"circRNA9963 was predicted to sponge miR-185-3p in a circRNA_miRNA_mRNA network in chronic HBV infection, potentially influencing HBV-related target mRNAs (Ctsd, Ikbkg, Nupr1, Per1, Ttbk1)."	0.31
41463334	Biomolecules	2025	Molecular Network Analysis of HBV Persistent Infection from the Perspective of Whole Transcriptome.		circRNA9964			chronic HBV infection	MONDO:0005366	chronic hepatitis B virus infection	unknown	RNA-seq	"circRNA9964 was predicted to participate in the miR-185-3p-centered circRNA_miRNA_mRNA regulatory network during chronic HBV infection, potentially regulating HBV-related target mRNAs (Ctsd, Ikbkg, Nupr1, Per1, Ttbk1)."	0.31
41463334	Biomolecules	2025	Molecular Network Analysis of HBV Persistent Infection from the Perspective of Whole Transcriptome.	mmu_circ_0001465				chronic HBV infection	MONDO:0005366	chronic hepatitis B virus infection	unknown	RNA-seq	"mmu_circ_0001465 was predicted as a DEcircRNA that competitively binds miR-185-3p within a circRNA_miRNA_mRNA network, potentially regulating HBV-related genes (Ctsd, Ikbkg, Nupr1, Per1, Ttbk1) and influencing host immune response in chronic HBV infection."	0.31
41463334	Biomolecules	2025	Molecular Network Analysis of HBV Persistent Infection from the Perspective of Whole Transcriptome.	mmu_circ_0011246				chronic HBV infection	MONDO:0005366	chronic hepatitis B virus infection	unknown	RNA-seq	"mmu_circ_0011246 was predicted to be involved in the miR-185-3p-centered ceRNA network in chronic HBV infection, potentially modulating HBV-related target mRNAs (Ctsd, Ikbkg, Nupr1, Per1, Ttbk1) and host immune response."	0.31
41471859	Microorganisms	2025	Comprehensive Bioinformatics Analysis the circRNAs of Viral Infection Associated Pathway in HepG2 Expressing ORF3 of Genotype IV Swine Hepatitis E Virus.		ciRNA203			viral infection / SHEV infection	MONDO:0005108	viral infectious disease	down-regulated	RNA-seq	"ciRNA203 is predicted (from RNA-seq differential expression and in-silico targeting) to participate in a ceRNA network in ORF3-overexpressing HepG2 cells, potentially sequestering miRNAs and thereby modulating viral infection pathway-related mRNAs (e.g., HSPA8/HSPA1B, EGR2, NOTCH3)."	0.1768
41471859	Microorganisms	2025	Comprehensive Bioinformatics Analysis the circRNAs of Viral Infection Associated Pathway in HepG2 Expressing ORF3 of Genotype IV Swine Hepatitis E Virus.		circRNA14936			viral infection / SHEV infection	MONDO:0005108	viral infectious disease	up-regulated	RNA-seq	circRNA14936 is identified as an up-regulated circRNA in ORF3-overexpressing HepG2 cells and is proposed (bioinformatically) as a core ceRNA component that may sponge miRNAs to regulate viral infection pathway-related mRNAs.	0.1768
41471859	Microorganisms	2025	Comprehensive Bioinformatics Analysis the circRNAs of Viral Infection Associated Pathway in HepG2 Expressing ORF3 of Genotype IV Swine Hepatitis E Virus.		circRNA5510			viral infection / SHEV infection	MONDO:0005108	viral infectious disease	down-regulated	RNA-seq	"circRNA5510 is down-regulated in ORF3-overexpressing HepG2 cells and is proposed as a key circRNA in the predicted viral infection-related ceRNA network, potentially regulating targets such as ZNF527 and NOTCH3 via miRNA sequestration."	0.1768
41471859	Microorganisms	2025	Comprehensive Bioinformatics Analysis the circRNAs of Viral Infection Associated Pathway in HepG2 Expressing ORF3 of Genotype IV Swine Hepatitis E Virus.		circRNA5562			viral infection / SHEV infection	MONDO:0005108	viral infectious disease	down-regulated	RNA-seq	"circRNA5562 is down-regulated in ORF3-overexpressing HepG2 cells and is proposed as a core circRNA in a predicted viral infection-related ceRNA network, potentially modulating EGR2 and SOCS3 via miRNA sequestration."	0.1768
41471859	Microorganisms	2025	Comprehensive Bioinformatics Analysis the circRNAs of Viral Infection Associated Pathway in HepG2 Expressing ORF3 of Genotype IV Swine Hepatitis E Virus.		circRNA5591			viral infection / SHEV infection	MONDO:0005108	viral infectious disease	down-regulated	RNA-seq	"circRNA5591 is down-regulated in ORF3-overexpressing HepG2 cells and is highlighted as a shared/hub circRNA in the predicted viral infection-associated ceRNA network, potentially regulating multiple targets (e.g., HSPA8/HSPA1B, EGR2, SOCS3, ZNF527, CXCR4) via miRNA sequestration."	0.1768
41471859	Microorganisms	2025	Comprehensive Bioinformatics Analysis the circRNAs of Viral Infection Associated Pathway in HepG2 Expressing ORF3 of Genotype IV Swine Hepatitis E Virus.		circRNA5619			viral infection / SHEV infection	MONDO:0005108	viral infectious disease	down-regulated	RNA-seq	"circRNA5619 is down-regulated in ORF3-overexpressing HepG2 cells and is proposed as a shared/hub circRNA within a predicted viral infection-related ceRNA network, potentially modulating HSPA8/HSPA1B, SOCS3, and CXCR4 via miRNA sequestration."	0.1768
41471859	Microorganisms	2025	Comprehensive Bioinformatics Analysis the circRNAs of Viral Infection Associated Pathway in HepG2 Expressing ORF3 of Genotype IV Swine Hepatitis E Virus.		circRNA8848			viral infection / SHEV infection	MONDO:0005108	viral infectious disease	down-regulated	RNA-seq	"circRNA8848 is down-regulated in ORF3-overexpressing HepG2 cells and is proposed as a shared/hub circRNA in the predicted SHEV infection-associated ceRNA network, potentially regulating viral infection-related mRNAs via competitive miRNA binding."	0.1768
41477335	Acta pharmaceutica Sinica. B	2025	IGF2BP1 positively regulates CircOGDH accumulation in hypoxia induced stress granules.		CircOGDH	hsa_circ_OGDH		ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR	"CircOGDH is up-regulated in hypoxic neurons/ischemic penumbra and becomes enriched with m6A. IGF2BP1 binds m6A-modified CircOGDH and recruits it into stress granules to stabilize it, thereby promoting hypoxia-associated neuronal injury/apoptosis in acute ischemic stroke models."	0.8355
41483179	Cellular and molecular life sciences : CMLS	2026	Hsa_circ_PCNT sponges hsa-miR-133b to promote SHH medulloblastoma via TAGLN2.		hsa_circ_030378	hsa_circ_PCNT	PCNT	medulloblastoma / MB	MONDO:0007959	medulloblastoma	up-regulated	RT-qPCR; RNA-seq	"In SHH medulloblastoma, hsa_circ_PCNT is up-regulated and mainly localized in the cytoplasm. It promotes malignant phenotypes (proliferation, migration, invasion, EMT) and inhibits apoptosis by acting as a ceRNA sponge for hsa-miR-133b, thereby relieving repression of TAGLN2; circRNA knockdown suppresses tumor growth in an orthotopic xenograft model."	0.7928
41484978	BMC biology	2026	Hypoxia-induced exosomal circ_0006840 promotes pancreatic cancer progress by regulating the WIF1 decay.	hsa_circ_0006840	circ_0006840	hsa_circ_TRA2B	TRA2B	pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; ISH; RNA-seq	"circ_0006840 is up-regulated in pancreatic cancer tissues and serum exosomes and is associated with poor survival. It is transcriptionally activated under hypoxia by HIF1A via the TRA2B promoter and promotes proliferation and metastasis by binding WIF1 mRNA/pre-mRNA and accelerating WIF1 transcript decay, thereby enhancing Wnt/beta-catenin-associated tumor progression."	0.898
41484997	BMC infectious diseases	2026	Circular RNA SETD2 (circSETD2) elevates DDX3 expression to inhibit autophagy in hepatitis B virus infection via targeting miR-181a-5p.	hsa_circ_0065173	circRNA SET domain containing 2 / circSETD2	hsa_circ_SETD2	SETD2	hepatitis B virus infection / HBV infection	MONDO:0005344	hepatitis B virus infection	down-regulated	RT-qPCR	"In HBV-infected hepatic cell models, circSETD2 is down-regulated by HBV/HBx. Restoring circSETD2 suppresses HBV viral load and inhibits autophagy by sponging miR-181a-5p, thereby increasing DDX3 expression."	0.5607
41486887	"Advanced science (Weinheim, Baden-Wurttemberg, Germany)"	2026	CircTspan3 Promotes Cartilage Development Through ANNEXIN A2-Mediated Ferroptosis and Apoptosis Inhibition and Exosome-Mediated Paracrine Signaling.	mmu_circ_0001775	circTspan3	mmu_circ_Tspan3	Tspan3	chondrodysplasia	MONDO:0022723	chondrodysplasia	down-regulated	RT-qPCR; RNA-seq	"circTspan3 (mmu_circ_0001775), derived from Tspan3 exons 2_6, is downregulated in Xbp1 cKO mice with chondrodysplasia. It promotes cartilage anabolism and growth/repair by suppressing apoptosis and ferroptosis, and it binds/stabilizes ANXA2; Ser26-phosphorylated ANXA2 enables circTspan3 trafficking and selective exosomal loading to drive paracrine chondroprotection."	0.8574
41491503	Molecular cancer	2026	EIF4A3/circPTGR1/miR-4725-5p positive- feedback loop promotes colorectal cancer progression via FAK/AKT signaling pathway.	hsa_circ_0003731	circPTGR1	hsa_circ_PTGR1	PTGR1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"circPTGR1 (hsa_circ_0003731) is upregulated in colorectal cancer and promotes CRC proliferation, migration, invasion, EMT and metastasis. It sponges miR-4725-5p to increase FAK and activate the FAK/AKT (PI3K/AKT-related) pathway, and is embedded in a positive feedback loop with EIF4A3 and miR-4725-5p. High circPTGR1 expression correlates with worse overall survival, suggesting prognostic value."	0.8657
41504772	Journal of cancer research and clinical oncology	2026	Profiling and functional analysis of exosomal circRNAs from EBV-associated gastric carcinoma CSCs.		ebv-circLMP2A / circLMP2A	ebv_circ_LMP2A	LMP2A	EBV-associated gastric carcinoma / EBVaGC	MONDO:0017784	Epstein-Barr virus-associated gastric carcinoma	up-regulated	RT-qPCR; RNA-seq	"ebv-circLMP2A is enriched and up-regulated in EBVaGC CSC-derived exosomes and is higher in EBVaGC tissues from patients with metastasis. CSC-derived exosomes promote invasive growth phenotypes in recipient EBVaGC cells, and ebv-circLMP2A is predicted (bioinformatically) to interact with miRNAs such as hsa-miR-4779/miR-5683, though direct binding was not experimentally validated."	0.7756
41504772	Journal of cancer research and clinical oncology	2026	Profiling and functional analysis of exosomal circRNAs from EBV-associated gastric carcinoma CSCs.		hsa-circRNF13 / Exo-circRNF13	hsa_circ_RNF13	RNF13	EBV-associated gastric carcinoma / EBVaGC	MONDO:0017784	Epstein-Barr virus-associated gastric carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa-circRNF13 is enriched and up-regulated in EBVaGC CSC-derived exosomes and is higher in EBVaGC tissues from patients with metastasis. Its expression is negatively correlated with hsa-miR-5683 in EBVaGC tissues, supporting a potential circRNA/miRNA regulatory relationship, and it may have value as a circulating exosomal biomarker (xenograft serum exosomes)."	0.7113
41508108	Journal of ovarian research	2026	CircRNA14781 promotes olaparib resistance of ovarian cancer cells by regulating miR-330-5p/NGFR pathway.	hsa_circ_0014781	circRNA14781	hsa_circ_MRPL24	MRPL24	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; RNA-seq	"circRNA14781 is upregulated in olaparib-resistant ovarian cancer cell models and promotes olaparib resistance, colony formation and migration. Mechanistically, it sponges miR-330-5p to relieve repression of NGFR, thereby strengthening the resistant phenotype and DNA repair capacity."	0.5997
41510160	Theranostics	2026	Mechanosensitive snoRNA-like circular RNA sno-circCNOT1 drives endothelial dysfunction and atherosclerosis.	hsa_circ_0000705	sno-circCNOT1	hsa_circ_CNOT1	CNOT1	atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR; RNA-seq	"sno-circCNOT1 (hsa_circ_0000705), derived from CNOT1, is induced by pro-atherogenic stimuli and promotes endothelial pyroptosis/inflammation, aggravating atherosclerosis in ApoE_/_ mice. Mechanistically it localizes to the nucleus via a snoRNA-like motif, binds and stabilizes LMNA, which stabilizes METTL14 to enhance m6A-dependent NLRP3 expression, activating inflammatory pyroptotic signaling."	0.8291
41513602	Cell death discovery	2026	CircZBTB46 alleviates metabolic dysfunction-associated steatotic liver disease by targeting miRNA-326/FGF1 axis.	hsa_circ_0002805	circZBTB46	hsa_circ_ZBTB46	ZBTB46	metabolic-associated fatty liver disease / MAFLD	MONDO:0013209	metabolic dysfunction-associated steatotic liver disease	down-regulated	RT-qPCR; RNA-seq	"circZBTB46 is down-regulated in MASLD/MASH liver tissues and in experimental steatosis models. It reduces hepatic lipid accumulation by sponging miRNA-326, restoring FGF1 expression and increasing AMPK activation (phosphorylation)."	0.7825
41514351	BMC veterinary research	2026	Analysis and identification of circRNA-regulated ceRNA networks associated with the virulence differences between PRV FA and FB strains.		animalcirc_014421			pseudorabies virus (PRV) infection	MONDO:0005108	viral infectious disease	up-regulated	RT-qPCR; RNA-seq	"animalcirc_014421 is significantly up-regulated in FB-infected BHK-21 cells compared with FA. It is included in a predicted circRNA_miRNA_mRNA ceRNA network (e.g., animalcirc_014421/maua-mir-1814/Pik3r1) that may contribute to PRV strain-dependent differences in replication/virulence, potentially involving apoptosis- and lysosome-related processes."	0.5971
41514351	BMC veterinary research	2026	Analysis and identification of circRNA-regulated ceRNA networks associated with the virulence differences between PRV FA and FB strains.		animalcirc_004115			pseudorabies virus (PRV) infection	MONDO:0005108	viral infectious disease	up-regulated	RT-qPCR; RNA-seq	"animalcirc_004115 is significantly up-regulated in FB-infected BHK-21 cells compared with FA. It participates in a predicted ceRNA network (e.g., animalcirc_004115/maua-mir-1814/ctsk) potentially linked to PRV strain-dependent replication/virulence differences, with implicated processes including apoptosis and lysosomal regulation at the network level."	0.5971
41514351	BMC veterinary research	2026	Analysis and identification of circRNA-regulated ceRNA networks associated with the virulence differences between PRV FA and FB strains.		animalcirc_010807			pseudorabies virus (PRV) infection	MONDO:0005108	viral infectious disease	up-regulated	RT-qPCR; RNA-seq	"animalcirc_010807 is significantly up-regulated in FB-infected BHK-21 cells compared with FA. It is part of a predicted ceRNA axis (animalcirc_010807/maua-mir-21-3/Pou2f1) that may contribute to PRV strain-related differences in replication/virulence, with implicated apoptosis/lysosome-related processes at the level of predicted targets."	0.5971
41514351	BMC veterinary research	2026	Analysis and identification of circRNA-regulated ceRNA networks associated with the virulence differences between PRV FA and FB strains.		animalcirc_000091			pseudorabies virus (PRV) infection	MONDO:0005108	viral infectious disease	down-regulated	RT-qPCR; RNA-seq	"animalcirc_000091 is significantly down-regulated in FB-infected BHK-21 cells compared with FA. It is included in predicted ceRNA subnetworks such as animalcirc_000091/maua-mir-877-3/Ctsd, animalcirc_000091/maua-mir-155-1/Entpd4, and animalcirc_000091/maua-undef-570/Smpd1, which may relate to lysosome- and apoptosis-associated host responses influencing PRV replication/virulence differences."	0.5971
41516402	International journal of molecular sciences	2026	Subtype-Specific m6A circRNA Methylation Patterns Identify Epigenetic Biomarker Candidates of Potential Diagnostic and Prognostic Significance in Breast Cancer.		hsa_circRNA_404935 / circZBTB16	hsa_circ_ZBTB16	ZBTB16	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	Microarray	"hsa_circRNA_404935 (circZBTB16) is identified as a TNBC-associated circRNA with increased m6A methylation and reported upregulation versus luminal tumors, showing strong diagnostic discrimination (AUC ~0.88). The study links it to Wnt/beta-catenin-related enrichment and suggests prognostic relevance through the host gene ZBTB16 being associated with worse OS in TNBC."	0.6405
41516402	International journal of molecular sciences	2026	Subtype-Specific m6A circRNA Methylation Patterns Identify Epigenetic Biomarker Candidates of Potential Diagnostic and Prognostic Significance in Breast Cancer.		hsa_circRNA_100719 / circDOCK1	hsa_circ_DOCK1	DOCK1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	Microarray	"hsa_circRNA_100719 (circDOCK1) is reported as hypermethylated and upregulated in TNBC relative to luminal subtypes. It is suggested to act as a miRNA sponge (miR-936) in angiogenesis-related contexts, linking it to VEGFA_VEGFR2 pathway regulation, but without direct functional validation in this study."	0.453
41516402	International journal of molecular sciences	2026	Subtype-Specific m6A circRNA Methylation Patterns Identify Epigenetic Biomarker Candidates of Potential Diagnostic and Prognostic Significance in Breast Cancer.		hsa_circRNA_057041 / circMETTL8	hsa_circ_METTL8	METTL8	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	Microarray	"hsa_circRNA_057041 (circMETTL8) is reported as a TNBC-associated circRNA with increased m6A methylation (and discussed as upregulated in TNBC). The study positions it as a candidate biomarker linked to aggressive TNBC-associated biological programs, though without circRNA-specific functional experiments."	0.453
41516402	International journal of molecular sciences	2026	Subtype-Specific m6A circRNA Methylation Patterns Identify Epigenetic Biomarker Candidates of Potential Diagnostic and Prognostic Significance in Breast Cancer.		hsa_circRNA_404557 / VAV3 circRNA	hsa_circ_VAV3	VAV3	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	Microarray	"hsa_circRNA_404557 (VAV3 circRNA) is reported as hypomethylated and downregulated in TNBC, with very high diagnostic discrimination (AUC = 1.0) between TNBC and luminal tumors. Its functional relevance is discussed mainly through host-gene/pathway context (e.g., CDC42/Rho GTPase-related programs), without direct mechanistic validation for this circRNA."	0.5668
41520563	Redox biology	2026	Fibroblast circSamd4 promotes cardiac fibrosis via activating plasminogen activator inhibitor-1.		circSamd4	hsa_circ_SAMD4	Samd4	cardiac fibrosis	MONDO:0004994	cardiomyopathy	up-regulated	RT-qPCR; Microarray	circSamd4 is upregulated in fibrotic hearts and enriched in cardiac fibroblasts. It promotes cardiac fibroblast proliferation/migration/activation and exacerbates cardiac fibrosis by acting as a ceRNA sponge for miR-1894-3p to upregulate Serpine1 (PAI-1).	0.8395
41520563	Redox biology	2026	Fibroblast circSamd4 promotes cardiac fibrosis via activating plasminogen activator inhibitor-1.		circSamd4	mmu_circ_Samd4	Samd4	cardiac fibrosis	MONDO:0004994	cardiomyopathy	up-regulated	RT-qPCR; Microarray	circSamd4 is upregulated in fibrotic hearts and enriched in cardiac fibroblasts. It promotes cardiac fibroblast proliferation/migration/activation and exacerbates cardiac fibrosis by acting as a ceRNA sponge for miR-1894-3p to upregulate Serpine1 (PAI-1).	0.8395
41530723	World journal of surgical oncology	2026	Circular RNA hsa_circ_0001829 promotes pancreatic ductal adenocarcinoma through miR-7113-3p/DTX4 axis.	hsa_circ_0001829		hsa_circ_SLC45A4	SLC45A4	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001829 is up-regulated in PDAC tissues and cell lines and promotes malignant phenotypes (proliferation, migration, invasion) while reducing apoptosis and altering the cell cycle. Mechanistically, it functions as a sponge for miR-7113-3p to de-repress DTX4, thereby enhancing PDAC progression, and its knockdown suppresses tumor growth in a nude-mouse xenograft model."	0.7899
41530849	Molecular cancer	2026	"CircROR1 binds HNRNPL to regulate FOXO4 pre-mRNA splicing, promoting cutaneous melanoma metastasis and serving as a therapeutic target via RNAi-loaded PEG-LNPs."	hsa_circ_0000082	circROR1 / Circ0000082	hsa_circ_ROR1	ROR1	cutaneous melanoma	MONDO:0005012	cutaneous melanoma	up-regulated	RT-qPCR; Microarray	"circROR1 is up-regulated in cutaneous melanoma, especially metastatic tumors, and promotes proliferation, EMT, migration/invasion, and metastasis while inhibiting apoptosis. Mechanistically, it binds the splicing factor HNRNPL to modulate FOXO4 pre-mRNA splicing (FOXO4alpha/FOXO4zeta switch) and is also linked to reduced PD-L1 expression and PD-L1-antibody therapy resistance. Therapeutic siRNA delivery targeting circROR1 via FA-PEG nanoparticles suppresses melanoma lung colonization in vivo."	0.8671
41530875	Stem cell research & therapy	2026	The circ_0042103/TAF15/NER axis regulates inflammation and DNA damage in pulpitis.	hsa_circ_0042103	circ_0042103 / circRNA_0042103	hsa_circ_MYOCD	MYOCD	pulpitis	MONDO:0006937	pulpitis	up-regulated	RT-qPCR; RNA-seq	"circ_0042103 is upregulated in LPS-stimulated hDPSCs and is associated with pulpitis-related inflammation and DNA damage. It directly binds the RBP TAF15, alters its localization, and suppresses NER (reduced ERCC1/PCNA), thereby enhancing DNA damage and IL-8-centered inflammatory responses."	0.7519
41530882	European journal of medical research	2026	Circ-PRKCI attenuates acute lung injury secondary to sepsis by targeting the miR-106b-5p/GAB1 axis.		circ-PRKCI / circ_PRKCI	mmu_circ_PRKCI	PRKCI	acute lung injury / ALI	MONDO:0015796	acute lung injury	down-regulated	RT-qPCR	"circ-PRKCI is down-regulated in sepsis-induced ALI (patient plasma and LPS-treated MLE-12 cells) and mainly localizes in the cytoplasm. It protects against ALI-associated cell injury by sponging miR-106b-5p and relieving repression of GAB1, thereby reducing inflammation, apoptosis, and oxidative stress; circ-PRKCI overexpression also ameliorates lung injury in a CLP mouse model."	0.7455
41536678	Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition	2025	"[Underlying Mechanism of the circ_0011462/miRNA-1200/SP1 Axis in Regulating Inflammatory Response, Apoptosis, and Neural Regeneration in a Spinal Cord Injury Model]."	rno_circ_0011462	circ_0011462			spinal cord injury / SCI	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR	"In a rat SCI model and injured PC12 cells, circ_0011462 is up-regulated and functions as a sponge for miR-1200, thereby increasing SP1 expression. Knockdown of circ_0011462 elevates miR-1200, suppresses SP1, reduces inflammatory cytokines and M1 microglia activation, decreases neuronal apoptosis, and enhances axonal growth/neural regeneration; SP1 overexpression or miR-1200 inhibition rescues these effects."	0.6542
41541658	MedComm	2026	N6-Methyladenosine Modification of circIST1 Promotes Hypoxia-Inducible Factor alpha-mediated Glycolysis and Progression in Hepatocellular Carcinoma.	hsa_circ_0005016	circIST1	hsa_circ_IST1	IST1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circIST1 is up-regulated in hepatocellular carcinoma and predicts poorer survival. METTL3-dependent m6A modification stabilizes circIST1, which mainly localizes to the cytoplasm and promotes HCC proliferation/migration/invasion while inhibiting apoptosis. Mechanistically, circIST1 acts as a ceRNA to sponge miR-140-3p and miR-182, derepressing HIF-1alpha and enhancing HIF-1alpha-driven aerobic glycolysis."	0.8793
41543155	International journal of oncology	2026	<p>Circ72309 modulates gemcitabine metabolism and gemcitabine sensitivity in pancreatic cancer: Serum Circ72309 levels as a potential predictor of treatment response</p>.		circ72309			pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	down-regulated	RT-qPCR; RNA-seq	"circ72309 is down-regulated in gemcitabine-resistant pancreatic cancer cell lines and its overexpression increases gemcitabine sensitivity by promoting gemcitabine-induced apoptosis. Mechanistically, circ72309 elevates ROS to suppress CDA and, via regulation/adsorption of miR-1225-3p and miR-1234, increases SLC29A1/hENT1, affecting multiple steps of gemcitabine metabolism. Clinically, higher pre-treatment serum circ72309 predicts better response to gemcitabine-based neoadjuvant therapy and longer PFS."	0.7942
41545948	Biological procedures online	2026	A Multi-Center Cohort-Based circRNA Diagnostic Model for Detection of Gastric Cancer.	hsa_circ_0001185	circ1185	hsa_circ_IFNGR2	IFNGR2	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0001185 is significantly up-regulated in the serum of gastric cancer patients (also elevated in gastritis vs healthy controls) and shows strong diagnostic performance (AUC 0.909). It is included with hsa_circ_0005265 in a multicenter logistic-regression diagnostic model (GC-DM) and its higher expression correlates with more aggressive clinicopathological features such as lymph node metastasis and advanced TNM stage.	0.7734
41545948	Biological procedures online	2026	A Multi-Center Cohort-Based circRNA Diagnostic Model for Detection of Gastric Cancer.	hsa_circ_0005265	circ5265	hsa_circ_PTPRA	PTPRA	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005265 is significantly up-regulated in the serum of gastric cancer patients (also elevated in gastritis vs healthy controls) and provides diagnostic value (AUC 0.853). It is used with hsa_circ_0001185 to build and validate a multicenter diagnostic model (GC-DM), and higher expression is associated with more invasive clinicopathological features such as deeper infiltration, nerve/vascular invasion, and higher TNM stage."	0.7734
41560974	Oncology letters	2026	Circular RNA hsa_circ_0006168: A potential biomarker for the diagnosis and prognosis of prostate cancer.	hsa_circ_0006168	circCNOT6L	hsa_circ_CNOT6L	CNOT6L	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0006168 is up-regulated in prostate cancer (tissue datasets and patient serum) and is elevated in androgen-independent PCa cell lines (DU145 and PC-3). Clinically, higher serum levels show diagnostic value (AUC 0.773) and are associated with poorer overall survival. Bioinformatics suggests potential involvement in the p53 signaling pathway and a possible ceRNA interaction with miR-205, but this mechanism is not experimentally validated in this study."	0.6895
41561631	Frontiers in cell and developmental biology	2025	A novel protein encoded by circIMP3 promotes prostate cancer progression by regulating alternative splicing and tumor microenvironment.		circIMP3	hsa_circ_IMP3	IMP3	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; RNA-seq	"circIMP3 is up-regulated in prostate cancer tissues and patient peripheral blood and is associated with poorer event-free survival. It encodes the peptide circIMP3_288aa and promotes prostate cancer proliferation and xenograft tumor growth. Mechanistically, it drives alternative splicing of FBXW7, reducing c-Myc ubiquitination and stabilizing c-Myc, and it can be transferred via exosomes to enhance recipient-cell proliferation within the tumor microenvironment."	0.7932
41564714	JACC. Basic to translational science	2026	Human Left Ventricle circRNA-miRNA-mRNA Network Analyses Reveal a Novel Proangiogenic Role for circNPHP1 Under Ischemic Conditions.		circNPHP1	hsa_circ_NPHP1	NPHP1	ischemic heart disease / IHD	MONDO:0024644	myocardial ischemia	up-regulated	RT-qPCR; RNA-seq	"circNPHP1 is up-regulated in human left ventricle biopsies from IHD patients (especially with T2DM) and in endothelial cells under hypoxia/hypoxia+high glucose. It promotes endothelial proliferation and angiogenic cord formation by sponging miR-221-3p, thereby sustaining VEGFA and BCL2 expression (a proangiogenic circNPHP1/miR-221-3p/VEGFA/BCL2 axis)."	0.7785
41568058	Biochemistry and biophysics reports	2026	Integrated bioinformatics and tissue-based validation reveal the oncogenic role of hsa_circ_0043256 and hsa_circ_0004789 in gastric cancer.	hsa_circ_0043256	circ_0043256 / hsa_circACACA_033	hsa_circ_ACACA	ACACA	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0043256 is up-regulated in gastric cancer tissues and is proposed to act as a ceRNA sponge for hsa-miR-28_5p, relieving repression of CCNB1 and thereby supporting cell-cycle progression. It shows diagnostic value by ROC analysis and is associated with lymphatic invasion in the patient cohort."	0.5534
41568058	Biochemistry and biophysics reports	2026	Integrated bioinformatics and tissue-based validation reveal the oncogenic role of hsa_circ_0043256 and hsa_circ_0004789 in gastric cancer.	hsa_circ_0004789	circ_0004789 / hsa_circSMURF2_006	hsa_circ_SMURF2	SMURF2	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0004789 is up-regulated in gastric cancer tissues and is proposed to sponge hsa-miR-5683 to increase CCNB1 expression, supporting a ceRNA model linked to cell-cycle progression. It shows strong diagnostic performance (including combined ROC AUC 0.9912) and correlates with several clinicopathological features; higher expression trends toward worse survival though not statistically significant in this cohort."	0.5534
41568718	The Journal of international medical research	2026	Clinical and pathophysiological significance of circ-0049271 in acute ST-segment elevation myocardial infarction.	hsa_circ_0049271	circ-0049271			ST-segment elevation myocardial infarction / STEMI	MONDO:0041656	ST-elevation myocardial infarction	up-regulated	RT-qPCR	"circ-0049271 is up-regulated in peripheral blood from STEMI patients (including post-PCI timepoints) and correlates with CK-MB, LVEF, ischemic duration, and Gensini score. In HUVEC oxidative stress models, circ-0049271 increases with H2O2 exposure and is linked to oxidative stress/endothelial dysfunction; miR-29a-3p and miR-17-3p are proposed downstream miRNA targets by bioinformatics, supporting potential biomarker utility for STEMI diagnosis."	0.6765
41570994	The Journal of biological chemistry	2026	The KANSL1-ARL17A fusion gene generates oncogenic chKANSARL and F-circKA RNAs that synergistically drive lung cancer progression via a novel F-circKA/miR-6860/chKANSARL axis.		F-circKA		KANSARL	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"F-circKA is a KANSARL fusion-derived circular RNA detected in lung cancer cell lines and mainly localized in the cytoplasm. It promotes proliferation, migration and invasion, and acts as a ceRNA sponge for miR-6860 to relieve repression of chKANSARL, forming a F-circKA/miR-6860/chKANSARL oncogenic axis."	0.7639
41585093	Tobacco induced diseases	2026	Cigarette smoke-induced circFOXO3 upregulation enhances autophagy-regulated senescence of type II alveolar cells through interacting with E2F1.		circRNA FOXO3 (circFOXO3) / circFOXO3	mmu_circ_Foxo3	FOXO3	chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR	"In mouse AT-II MLE-12 cells and a cigarette-smoke-exposed mouse model, circFOXO3 is induced by cigarette smoke/CSE and promotes AT-II cell senescence. Mechanistically, circFOXO3 binds the transcription factor E2F1, suppresses its nuclear translocation, inhibits autophagy, and thereby aggravates lung injury-related senescence."	0.5925
41593693	Journal of translational medicine	2026	CircCCDC66 promotes the progression and EMT of renal cell carcinoma via the miR-1278/HOXA13 axis.		CircCCDC66	hsa_circ_CCDC66	CCDC66	clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR	"CircCCDC66 is upregulated in ccRCC tissues and cell lines and promotes tumor growth, proliferation, migration/invasion, and EMT. Mechanistically, it acts as a cytoplasmic ceRNA that sponges miR-1278, relieving repression of HOXA13 and driving ccRCC progression."	0.8623
41595454	Genes	2025	"circRNA Signatures Distinguishing COVID-19 Outcomes and Acute Respiratory Distress Syndrome: A Longitudinal, Two-Timepoint, Precision-Weighted Analysis of a Public RNA-Seq Cohort."		circTMCC2(3).1	hsa_circ_TMCC2	TMCC2	COVID-19 / Coronavirus disease 2019	MONDO:0100096	COVID-19	up-regulated	RNA-seq	"circTMCC2(3).1 is significantly increased in COVID-19 non-survivors versus survivors in a two-timepoint precision-weighted PBMC RNA-seq analysis. Predicted miRNA-binding and immune-cell enrichment analyses suggest it may relate to systemic immune dysregulation associated with mortality risk, but the mechanism is computational and requires experimental validation."	0.1768
41595454	Genes	2025	"circRNA Signatures Distinguishing COVID-19 Outcomes and Acute Respiratory Distress Syndrome: A Longitudinal, Two-Timepoint, Precision-Weighted Analysis of a Public RNA-Seq Cohort."		circCDYL(2).1	hsa_circ_CDYL	CDYL	COVID-19 / Coronavirus disease 2019	MONDO:0100096	COVID-19	up-regulated	RNA-seq	"circCDYL(2).1 is significantly increased in COVID-19 non-survivors versus survivors in a two-timepoint precision-weighted PBMC RNA-seq analysis. Predicted miRNA-binding and immune-cell enrichment analyses suggest potential involvement in systemic immune dysregulation, but this remains computational and needs experimental validation."	0.1768
41595454	Genes	2025	"circRNA Signatures Distinguishing COVID-19 Outcomes and Acute Respiratory Distress Syndrome: A Longitudinal, Two-Timepoint, Precision-Weighted Analysis of a Public RNA-Seq Cohort."		circANKRD12(S8).1	hsa_circ_ANKRD12	ANKRD12	COVID-19 / Coronavirus disease 2019	MONDO:0100096	COVID-19	up-regulated	RNA-seq	"circANKRD12(S8).1 is significantly increased in COVID-19 survivors versus non-survivors in a two-timepoint precision-weighted PBMC RNA-seq analysis. Predicted miRNA-interactor analysis found no immune-cell enrichment, implying it may mark survival-associated biology distinct from the immune-dysregulation-linked candidates."	0.1768
41595454	Genes	2025	"circRNA Signatures Distinguishing COVID-19 Outcomes and Acute Respiratory Distress Syndrome: A Longitudinal, Two-Timepoint, Precision-Weighted Analysis of a Public RNA-Seq Cohort."		"circRARS1(2,3,4,5).1"	hsa_circ_RARS1	RARS	COVID-19 / Coronavirus disease 2019	MONDO:0100096	COVID-19	dysregulated	RNA-seq	"circRARS1(2,3,4,5).1 shows direction-flipping differential expression across Early vs Late timepoints in COVID-19 outcome-related comparisons and is highlighted in a predicted circRNA_miRNA_immune cell network. Its immune relevance is inferential and based on computational predictions from circAtlas/MiEAA without experimental validation."	0.1768
41595454	Genes	2025	"circRNA Signatures Distinguishing COVID-19 Outcomes and Acute Respiratory Distress Syndrome: A Longitudinal, Two-Timepoint, Precision-Weighted Analysis of a Public RNA-Seq Cohort."		"circASPH(2,3).1"	hsa_circ_ASPH	AC090094	COVID-19 / Coronavirus disease 2019	MONDO:0100096	COVID-19	dysregulated	RNA-seq	"circASPH(2,3).1 is a direction-flipping circRNA across timepoints in the COVID-19 non-survivor vs survivor comparison and is included in a predicted circRNA_miRNA_immune cell network. Its proposed immune relevance is based on computational prediction/enrichment rather than experimental validation."	0.1768
41595666	Biomedicines	2026	Circuitous Ways of EWS::FLI1 Using Circular RNA ZNF609 to Evade Translational Repression by miR-145 in Ewing's Sarcoma.	hsa_circ_0000615	circZNF609	hsa_circ_ZNF609	ZNF609	Ewing¡¯s sarcoma / EwS	MONDO:0012817	Ewing sarcoma	up-regulated	RT-qPCR	"In Ewing¡¯s sarcoma cell lines, circZNF609 is highly expressed and predominantly cytoplasmic. It promotes proliferation and tumorigenic behaviors and inhibits apoptosis by sponging miR-145-5p, thereby relieving miR-145-5p-mediated translational repression of EWS::FLI1."	0.7446
41600612	Toxics	2026	Integrated ceRNA Network Analysis in Silica-Induced Pulmonary Fibrosis and Discovery of miRNA Biomarkers.		circRNA(18_60522864_60572570)			silicosis / silica-induced pulmonary fibrosis	MONDO:0005960	silicosis	up-regulated	RT-qPCR; RNA-seq	"In silica-induced pulmonary fibrosis (silicosis) mouse lung tissue, circRNA 18_60522864_60572570 is up-regulated and is proposed to act as a ceRNA by sponging miR-468a-5p and miR-468b-5p, thereby regulating fibrotic genes Fn1 and Fbln2."	0.5608
41600612	Toxics	2026	Integrated ceRNA Network Analysis in Silica-Induced Pulmonary Fibrosis and Discovery of miRNA Biomarkers.	mmu_circ_0010422	circRNA0010422			silicosis / silica-induced pulmonary fibrosis	MONDO:0005960	silicosis	down-regulated	RT-qPCR; RNA-seq	"In the mouse silicosis model lung tissue, mmu_circ_0010422 is significantly down-regulated after SiO2 exposure, consistent between RNA-seq and RT-qPCR, but no specific downstream mechanism was reported."	0.5608
41602344	Frontiers in cardiovascular medicine	2025	Hsa_circ_0005623 is an indicator for pulmonary artery hypertension associated with congenital heart disease.	hsa_circ_0005623	hsa_circ_005623	hsa_circ_SLC7A6	SLC7A6	pulmonary arterial hypertension / PAH	MONDO:0015924	pulmonary arterial hypertension	down-regulated	RT-qPCR; Microarray	"hsa_circ_0005623 (from SLC7A6) is significantly down-regulated in PAH-CHD, including in patient plasma and hypoxia-induced hPAECs. Its low plasma level correlates negatively with mPAP and shows diagnostic potential (AUC 0.805). Bioinformatic prediction suggests a circRNA_miRNA_mRNA ceRNA network involving miR-424-5p/miR-503-5p/miR-331-3p/miR-17-3p and endothelial-function-related hub genes."	0.5963
41603139	Journal of diabetes investigation	2026	Expression profile of circular RNAs in type 2 diabetes mellitus patients with retinopathy.		hsa_circ_087631 / circRNA HABP4	hsa_circ_HABP4	HABP4	diabetic retinopathy / DR	MONDO:0005266	diabetic retinopathy	down-regulated	RT-qPCR; Microarray	"In DR patient serum, hsa_circRNA_087631 (circRNA HABP4) is down-regulated and is predicted to act as a ceRNA by sponging hsa-miR-877-3p to regulate WNT10A, implicating Wnt-related signaling."	0.585
41603139	Journal of diabetes investigation	2026	Expression profile of circular RNAs in type 2 diabetes mellitus patients with retinopathy.		hsa_circ_101698 / CARHSP1	hsa_circ_CARHSP1	CARHSP1	diabetic retinopathy / DR	MONDO:0005266	diabetic retinopathy	down-regulated	RT-qPCR; Microarray	"In DR patient serum, hsa_circRNA_101698 (CARHSP1) is down-regulated and is predicted to sponge hsa-miR-92a-2-5p and hsa-miR-939-5p, thereby regulating NOTUM, TNF, HCN2, PAK4, and FGF17 in pathways enriched from the network analysis."	0.585
41603139	Journal of diabetes investigation	2026	Expression profile of circular RNAs in type 2 diabetes mellitus patients with retinopathy.		hsa_circ_102889			diabetic retinopathy / DR	MONDO:0005266	diabetic retinopathy	down-regulated	RT-qPCR; Microarray	"hsa_circ_102889 was identified as down-regulated in DR patient serum and included among circRNAs selected for downstream ceRNA-related functional analyses, but no specific miRNA/mRNA axis was reported in the provided text."	0.5541
41603139	Journal of diabetes investigation	2026	Expression profile of circular RNAs in type 2 diabetes mellitus patients with retinopathy.		hsa_circ_406551			diabetic retinopathy / DR	MONDO:0005266	diabetic retinopathy	down-regulated	RT-qPCR; Microarray	"hsa_circ_406551 was identified as down-regulated in DR patient serum and included among circRNAs selected for downstream functional analyses, but no specific mechanistic axis was provided in the text."	0.5541
41603139	Journal of diabetes investigation	2026	Expression profile of circular RNAs in type 2 diabetes mellitus patients with retinopathy.		hsa_circ_407262 / hsa_circRNA_407262	hsa_circ_LOC389906	LOC389906	diabetic retinopathy / DR	MONDO:0005266	diabetic retinopathy	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_407262 (circRNA LOC389906) is down-regulated in DR patient serum and is predicted to function as a miRNA sponge involved in Wnt, GnRH secretion, TNF, and Ras signaling pathways, suggesting biomarker potential for early DR diagnosis."	0.585
41603139	Journal of diabetes investigation	2026	Expression profile of circular RNAs in type 2 diabetes mellitus patients with retinopathy.		hsa_circ_005739			diabetic retinopathy / DR	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR; Microarray	"hsa_circ_005739 was identified as up-regulated in DR patient serum and included among circRNAs selected for downstream analyses, but no specific mechanistic interactions were described in the provided text."	0.5541
41603139	Journal of diabetes investigation	2026	Expression profile of circular RNAs in type 2 diabetes mellitus patients with retinopathy.		hsa_circ_103491			diabetic retinopathy / DR	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR; Microarray	"hsa_circ_103491 was identified as up-regulated in DR patient serum and included among circRNAs selected for downstream analyses, but no specific mechanistic interactions were described in the provided text."	0.5541
41603139	Journal of diabetes investigation	2026	Expression profile of circular RNAs in type 2 diabetes mellitus patients with retinopathy.		hsa_circ_405317			diabetic retinopathy / DR	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR; Microarray	"hsa_circ_405317 was identified as up-regulated in DR patient serum and included among circRNAs selected for downstream analyses, but no specific mechanistic interactions were described in the provided text."	0.5541
41608617	International journal of biological sciences	2026	The Interaction of CircESR1 and HNRNPAB Regulates Cell Cycle Transition of Breast Cancer Cell.	hsa_circ_0078310	circESR1	hsa_circ_ESR1	ESR1	ER-positive breast cancer	MONDO:0006512	estrogen-receptor positive breast cancer	up-regulated	RT-qPCR; Northern Blot; ISH; RNA-seq	"circESR1 (hsa_circ_0078310), derived from ESR1, is up-regulated in ER+ breast cancer and further increased in tamoxifen-resistant cells. It binds the RBP HNRNPAB, stabilizing HNRNPAB via reduced ubiquitination and forming a positive feedback loop in which HNRNPAB promotes circESR1 biogenesis by binding Alu elements of ESR1 pre-mRNA. Through this circESR1_HNRNPAB complex, CDK1 and CDK6 mRNAs are stabilized, promoting cell-cycle progression, proliferation and endocrine resistance; high circESR1 levels associate with advanced stage and poor survival."	0.8982
41608639	International journal of biological sciences	2026	CircCLMP Suppresses Anti-Tumor Immunity by Inhibiting Activation of IRF3 and Interferon Response in Microsatellite Instability-high Endometrial Cancer.	hsa_circ_0003997	circCLMP	hsa_circ_CLMP	CLMP	endometrial cancer / EC	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR; Microarray	"circCLMP is up-regulated in MSI endometrial cancer, particularly in ICI-resistant tumors, and is negatively associated with CD8+ T-cell infiltration. It binds IRF3 and blocks TBK1-mediated IRF3 activation, suppressing interferon response and anti-tumor immunity; targeting circCLMP enhances anti-PD-1 efficacy in MSI tumor models including MSI EC PDX."	0.8838
41612654	"Journal of cachexia, sarcopenia and muscle"	2026	EIF4A3-Induced Circular RNA circSnd1 Promotes Muscle Atrophy and Muscle Ageing by Stabilizing EEF1A1.	hsa_circ_0082113	circSnd1	hsa_circ_SND1	SND1	muscle atrophy	MONDO:0004323	muscular atrophy	up-regulated	RT-qPCR; RNA-seq	"circSnd1 is upregulated in multiple muscle atrophy models and aged muscle, and its overexpression promotes muscle atrophy and muscle ageing while its knockdown is protective. Mechanistically, EIF4A3 enhances circSnd1 biogenesis, and circSnd1 stabilizes EEF1A1 by facilitating FAT10 binding and reducing ubiquitination, thereby promoting atrophy-associated catabolic programs."	0.8516
41612654	"Journal of cachexia, sarcopenia and muscle"	2026	EIF4A3-Induced Circular RNA circSnd1 Promotes Muscle Atrophy and Muscle Ageing by Stabilizing EEF1A1.	mmu_circ_0013252	circSnd1	mmu_circ_Snd1	Snd1	muscle atrophy	MONDO:0004323	muscular atrophy	up-regulated	RT-qPCR; RNA-seq	"circSnd1 is upregulated in multiple muscle atrophy models and aged muscle, and its overexpression promotes muscle atrophy and muscle ageing while its knockdown is protective. Mechanistically, EIF4A3 enhances circSnd1 biogenesis, and circSnd1 stabilizes EEF1A1 by facilitating FAT10 binding and reducing ubiquitination, thereby promoting atrophy-associated catabolic programs."	0.8516
41620490	Scientific reports	2026	The expression profiling of serum circPHLPP2 and LncRNA ILF3 in colorectal cancer patients.		circular RNA PHLPP2 (circPHLPP2) / circPHLPP2	hsa_circ_PHLPP2	PHLPP2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"Serum circPHLPP2 is up-regulated in colorectal cancer patients and increases with advancing AJCC stage, with highest levels in metastatic disease. It shows strong diagnostic performance versus healthy controls and has moderate ability to distinguish metastatic from non-metastatic CRC, but no survival association was evaluated."	0.4758
41620724	Molecular cancer	2026	CircKIAA1617 promotes stemness via USP14/PGRMC1-mediated autophagy and lipid metabolism reprogramming in ER-positive breast cancer.	hsa_circ_0017636	circKIAA1617	hsa_circ_KIAA1617	KIAA1617	ER-positive breast cancer	MONDO:0006512	estrogen-receptor positive breast cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circKIAA1617 is upregulated in ER-positive breast cancer and is induced by estrogen/ERalpha, with biogenesis facilitated by EIF4A3. It promotes proliferation and stemness by inducing autophagy and lipophagy-driven lipid metabolic reprogramming via scaffolding USP14 and PGRMC1 to stabilize PGRMC1 through K48-linked deubiquitination at lysine 105, and high expression predicts poor overall survival."	0.901
41634201	Scientific reports	2026	RNA sequencing reveals differential expression of circular RNAs in human small cell lung cancer.	hsa_circ_0072309	circLIFR / circLIFR(2_5)	hsa_circ_LIFR	LIFR	Small cell lung cancer / SCLC	MONDO:0008433	small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	"circLIFR is significantly down-regulated in SCLC tissues and forms a predicted ceRNA network with 26 interacting miRNAs and 2,447 downstream mRNA targets. It shows strong diagnostic performance (AUC 0.9177), but its mechanistic interactions are computationally predicted and require functional validation."	0.6895
41634201	Scientific reports	2026	RNA sequencing reveals differential expression of circular RNAs in human small cell lung cancer.	hsa_circ_0001900	"circCAMSAP1 / circCAMSAP1(2,3)"	hsa_circ_CAMSAP1	CAMSAP1	Small cell lung cancer / SCLC	MONDO:0008433	small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"circCAMSAP1 is significantly up-regulated in SCLC tissues and is analyzed as a predicted ceRNA with 14 interacting miRNAs and 553 downstream mRNA targets. Its expression correlates with chemotherapy response (higher in progressive disease) and has moderate diagnostic accuracy (AUC 0.764), while mechanistic interactions remain computationally predicted."	0.6895
41654728	The journal of headache and pain	2026	hsa_circ_0006168 drives microglial activation in TNC via miR-99b-5p/KDM6B axis to promote central sensitization in migraine.	hsa_circ_0006168		hsa_circ_CNOT6L	CNOT6L	Migraine	MONDO:0005277	migraine disorder	up-regulated	RT-qPCR	"In migraine, hsa_circ_0006168 is up-regulated in patients¡¯ peripheral blood and is implicated in promoting central sensitization. Mechanistically, it acts as a ceRNA to sponge miR-99b-5p, relieving repression of KDM6B, which is linked to microglial activation in the TNC and PI3K/AKT signaling activation."	0.6193
41654728	The journal of headache and pain	2026	hsa_circ_0006168 drives microglial activation in TNC via miR-99b-5p/KDM6B axis to promote central sensitization in migraine.	mmu_circ_0012878		mmu_circ_Cnot6l		Migraine	MONDO:0005277	migraine disorder	up-regulated	RT-qPCR; ISH	"In the NTG-induced migraine mouse model and LPS-stimulated BV2 microglia, mmu_circ_0012878 is up-regulated and mainly cytoplasmic. Its knockdown reduces microglial activation, shifts polarization toward M2, and dampens central sensitization markers. Mechanistically, it sponges miR-99b-5p to increase KDM6B, with downstream involvement of PI3K/AKT signaling."	0.5997
41654935	Biology direct	2026	CircADAM9 activates autophagy via miR-302b-3p/ULK1 axis to improve depressive-like behaviors.	mmu_circ_0001665	circADAM9 / circ_0001665	mmu_circ_ADAM9	Adam9	Depression / major depressive disorder	MONDO:0002009	major depressive disorder	down-regulated	RT-qPCR; ISH; RNA-seq	"In a CUMS mouse depression model and in LPS-treated astrocytes, circADAM9 is down-regulated. circADAM9 overexpression alleviates depressive-like behaviors and restores ULK1-mediated autophagy by sponging miR-302b-3p and increasing Ulk1 expression."	0.907
41659252	Translational lung cancer research	2026	circ-UBR5 in hypoxia-induced exosomes may mediate lung adenocarcinoma metastasis via the targeting of HNRNPR.	hsa_circ_0085207	circ-UBR5	hsa_circ_UBR5	UBR5	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circ-UBR5 is enriched in hypoxia-induced LUAD exosomes and is upregulated in LUAD tumor tissue. After exosomal transfer to recipient normoxic LUAD cells, circ-UBR5 localizes to the nucleus, binds and upregulates HNRNPR, and promotes proliferation, migration/invasion and metastatic phenotypes. High circ-UBR5 expression is associated with advanced stage and poorer overall survival."	0.8252
41667834	Scientific reports	2026	BMSCs exosomes regulate pulmonary microvascular endothelial apoptosis via circRNA_43350/miR-342-5p in COPD.		circRNA_43350 / mmu_circRNA_43350	mmu_circ_Ciapin1	Ciapin1	chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	down-regulated	RT-qPCR; Microarray	"In a CSE-induced COPD mouse/PMVEC model, exosomal circRNA_43350 from BMSCs is reduced in COPD and its overexpression attenuates endothelial apoptosis and emphysema-like changes. Mechanistically, circRNA_43350 functions as a sponge for miR-342-5p, and miR-342-5p overexpression partially reverses the anti-apoptotic effect."	0.7795
41668805	"Cancer drug resistance (Alhambra, Calif.)"	2026	Circular RNA hsa-circ-0001030 suppresses proliferation and cisplatin tolerance in TSCC via interaction with PKM2.	hsa_circ_0001030	hsa-circ-0001030	hsa_circ_EXOC6B	EXOC6B	tongue squamous cell carcinoma / TSCC	MONDO:0000500	tongue squamous cell carcinoma	down-regulated	RT-qPCR; ISH; Microarray	"In TSCC, hsa-circ-0001030 is down-regulated and acts as a tumor suppressor that reduces proliferation, migration/invasion, tumor growth/metastasis, and cisplatin resistance. It directly binds PKM2 (138_169 nt), inhibits PKM2 activity and tetramer formation, increases PKM2 Tyr105 phosphorylation, and suppresses glycolysis, thereby improving cisplatin sensitivity."	0.8446
41669945	Journal of the American Heart Association	2026	CircRNA-TMEM71 Inhibits Human Aortic Smooth Muscle Cell Ferroptosis and Prevents Aortic Dissection Formation Through IGF2BP3-Mediated Stability of FSP1.	hsa_circ_0008205	circTMEM71 / circRNA-TMEM71	hsa_circ_TMEM71	TMEM71	aortic dissection / AD	MONDO:0022470	aortic dissection lentiginosis	down-regulated	RT-qPCR; RNA-seq	"circTMEM71 (hsa_circ_0008205), derived from TMEM71, is down-regulated in human AD aortic tissues and Ang II_treated HASMCs. It inhibits ferroptosis and protects against AD progression by binding the RBP IGF2BP3 to reduce its ubiquitin-proteasome degradation, thereby enhancing IGF2BP3-dependent stabilization of FSP1 mRNA."	0.877
41673675	Arthritis research & therapy	2026	Decreased expression of circ-CCDC134 mediated by TNF-alpha in patients with rheumatoid arthritis affects T cell function via targeting protein phosphatase 2A.		circ-UBXN7 / circ-UBX domain protein 7 (UBXN7)	hsa_circ_UBXN7	UBXN7	rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	down-regulated	RT-qPCR; RNA-seq	"circ-UBXN7 is down-regulated in RA T cells and its expression is inversely associated with RA disease activity (DAS28-ESR). It physically binds the RNA-binding protein PCBP2, suggesting a protein-binding regulatory role in T cells."	0.7164
41673675	Arthritis research & therapy	2026	Decreased expression of circ-CCDC134 mediated by TNF-alpha in patients with rheumatoid arthritis affects T cell function via targeting protein phosphatase 2A.		circ-CCDC134 / circ-Coiled-Coil Domain Containing 134 (CCDC134)	hsa_circ_CCDC134	CCDC134	rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	down-regulated	RT-qPCR; RNA-seq	"circ-CCDC134 is down-regulated in RA T cells and inversely correlates with disease activity. It binds PPP2R1A to inhibit PP2A, increasing AKT/STAT3 phosphorylation and promoting IL-2 and IFN-gamma production/secretion, which counteracts chronic TNF-alpha-induced T-cell functional suppression."	0.7689
41673675	Arthritis research & therapy	2026	Decreased expression of circ-CCDC134 mediated by TNF-alpha in patients with rheumatoid arthritis affects T cell function via targeting protein phosphatase 2A.		circ-PDXDC1 / circ-Pyridoxal Dependent Decarboxylase Domain Containing 1 (PDXDC1)	hsa_circ_PDXDC1	PDXDC1	rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	down-regulated	RT-qPCR; RNA-seq	"circ-PDXDC1 is down-regulated in RA T cells. Lower circ-PDXDC1 levels are associated with higher RA disease activity (DAS28-ESR), but no molecular mechanism was experimentally characterized in this study."	0.5135
41673707	Biomarker research	2026	RBM10 modulation of circRNA biogenesis contributes to its tumor suppressor role in lung adenocarcinoma.		circHIPK3	hsa_circ_HIPK3	HIPK3	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; RNA-seq	"circHIPK3 is an RBM10-dependent circRNA that is down-regulated in LUAD, especially in RBM10-mutant tumors. Functionally, increasing circHIPK3 suppresses LUAD cell growth and reduces xenograft tumor burden, consistent with a tumor-suppressor role linked to RBM10-mediated splicing/circularization control involving SF3B1."	0.7884
41673707	Biomarker research	2026	RBM10 modulation of circRNA biogenesis contributes to its tumor suppressor role in lung adenocarcinoma.		circSMARCA5	hsa_circ_SMARCA5	SMARCA5	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; RNA-seq	"circSMARCA5 is an RBM10-regulated circRNA with direct RBM10 binding at its flanking regions and position-dependent inhibition of circularization. In LUAD cells, circSMARCA5 knockdown reduces growth-related phenotypes, but patient data show decreased tumor expression and the authors suggest its clinical relevance may be limited or context-dependent."	0.8116
41673707	Biomarker research	2026	RBM10 modulation of circRNA biogenesis contributes to its tumor suppressor role in lung adenocarcinoma.		circCYP24A1	hsa_circ_CYP24A1	CYP24A1	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	unknown	RT-qPCR; RNA-seq	"circCYP24A1 is an RBM10-dependent circRNA identified by RNA-seq and confirmed by RT-qPCR in LUAD cell models, but direct RBM10 binding to its flanking sites was not supported by PAR-CLIP, suggesting indirect regulation."	0.1904
41673882	Journal of orthopaedic surgery and research	2026	Multiomics combined drugs to explore the potential mechanism and treatment of ankylosing spondylitis.	hsa_circ_0036579				ankylosing spondylitis / AS	MONDO:0005306	ankylosing spondylitis	down-regulated	Microarray	"hsa_circ_0036579 is proposed as an upstream regulator in AS ceRNA network. Its downregulation may increase hsa-miR-574-5p, which is suggested to inhibit STAT4 and affect the STAT4 downstream target IRF1."	0.1768
41673882	Journal of orthopaedic surgery and research	2026	Multiomics combined drugs to explore the potential mechanism and treatment of ankylosing spondylitis.	hsa_circ_0063062				ankylosing spondylitis / AS	MONDO:0005306	ankylosing spondylitis	down-regulated	Microarray	"hsa_circ_0063062 is proposed to participate in an AS-related ceRNA axis involving hsa-miR-574-5p and STAT4, with IRF1 as a downstream target gene of STAT4 in the constructed network."	0.1768
41673882	Journal of orthopaedic surgery and research	2026	Multiomics combined drugs to explore the potential mechanism and treatment of ankylosing spondylitis.	hsa_circ_0006696				ankylosing spondylitis / AS	MONDO:0005306	ankylosing spondylitis	down-regulated	Microarray	hsa_circ_0006696 is proposed as part of an AS ceRNA pathway (hsa_circ_0006696/hsa-miR-574-5p/STAT4/IRF1). The paper suggests its downregulation may contribute to STAT4 suppression via elevated hsa-miR-574-5p.	0.1768
41674950	Translational cancer research	2026	"Hsa_circ_0001756, a novel biomarker, promotes breast cancer progression via miR-584-5p/TRAF6 signaling axis."	hsa_circ_0001756	CircHIPK2 / circ_00001756	hsa_circ_HIPK2	HIPK2	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001756 (CircHIPK2) is up-regulated in breast cancer tissues/cells and promotes tumor growth, proliferation, migration, invasion and EMT. It mainly localizes to the cytoplasm and acts as a ceRNA sponge for miR-584-5p to upregulate TRAF6. Serum hsa_circ_0001756 is elevated in BC and has diagnostic value, especially combined with CEA and CA15-3."	0.8556
41676423	Archives of medical science : AMS	2025	CircRNA_103809/miR-516a/FBXL18 contributes to stemness and gemcitabine resistance of bladder cancer cells.		circRNA_103809			bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"CircRNA_103809 is up-regulated in bladder cancer cell lines and further elevated in gemcitabine-resistant cells. Functionally, circRNA_103809 promotes proliferation, migration/invasion, stemness and gemcitabine resistance, at least in part by sponging miR-516a to increase FBXL18 expression."	0.7631
41681969	Cancers	2026	Simultaneous Study of Circular RNAs and Messenger RNAs in Colorectal Cancer: The Unbalanced Fate of a Couple?		"circPOLD1(3-2) / circPOLD1(3,2)"	hsa_circ_POLD1	POLD1	hereditary colorectal cancer / CRC predisposition	MONDO:0023113	familial colorectal cancer	up-regulated	RNA-seq	"In peripheral blood from patients suspected of hereditary CRC, circPOLD1(3,2) is implicated as the main driver of an increased circRNA/mRNA ratio (relative to controls). The study suggests the imbalance likely reflects increased circRNA production/accumulation rather than reduced POLD1 mRNA, and highlights circPOLD1(3,2) as a candidate biomarker or contributor to CRC predisposition."	0.5297
41684556	Archives of medical science : AMS	2025	"Circular RNA circ_0001421 contributes to colony formation, migration, invasion and glycolysis of non-small cell lung cancer via the miR-409-3p/TMEM14A axis."	hsa_circ_0001421	circRNA_0001421 / circ_0001421			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0001421 is up-regulated in NSCLC tissues and cell lines and mainly localizes in the cytoplasm. Functionally, circ_0001421 promotes NSCLC colony formation, migration, invasion, glycolysis, and tumor growth in vivo by sponging miR-409-3p to increase TMEM14A expression."	0.6578
41688661	Scientific reports	2026	Cadmium exposure induces renal fibrosis by inhibiting hsa_circ_0075684/miR-363-3p/KLF4 signaling pathway.	hsa_circ_0075684		hsa_circ_MYLIP	MYLIP	renal fibrosis / RF	MONDO:0000494	renal fibrosis	down-regulated	RT-qPCR	"In cadmium-exposed renal tubular epithelial cells, hsa_circ_0075684 is down-regulated and functions as a ceRNA that sponges miR-363-3p, thereby restoring KLF4 expression. Overexpression of hsa_circ_0075684 mitigates cadmium-induced renal fibrosis marker changes (Fn, alpha-SMA, E-Cad)."	0.6521
41689003	BMC musculoskeletal disorders	2026	Circular RNAs coordinate immunomodulation in osteoarthritic cartilage via antigen presentation and adaptive immune response.		circPTK2-OA	hsa_circ_PTK2	PTK2	osteoarthritis / OA	MONDO:0005178	osteoarthritis	dysregulated	RNA-seq	"circPTK2-OA is a novel intronic circRNA differentially expressed in OA cartilage and is strongly associated (by coexpression/GSEA) with immune processes, particularly leukocyte chemotaxis and MHC class II antigen processing/presentation, suggesting a role in shaping adaptive immune activation in OA."	0.1768
41689003	BMC musculoskeletal disorders	2026	Circular RNAs coordinate immunomodulation in osteoarthritic cartilage via antigen presentation and adaptive immune response.		hsa-intergenic_00316			osteoarthritis / OA	MONDO:0005178	osteoarthritis	dysregulated	RNA-seq	"hsa-intergenic_00316 is a differentially expressed circRNA in OA cartilage whose coexpression/GSEA signals link it to leukocyte migration/chemotaxis and MHC class II antigen presentation, implying a role in joint immune activation programs."	0.1768
41689003	BMC musculoskeletal disorders	2026	Circular RNAs coordinate immunomodulation in osteoarthritic cartilage via antigen presentation and adaptive immune response.		hsa-HLA-DRB1_0002	hsa_circ_HLA-DRB1	HLA-DRB1	osteoarthritis / OA	MONDO:0005178	osteoarthritis	dysregulated	RNA-seq	"hsa-HLA-DRB1_0002 is a differentially expressed circRNA in OA cartilage associated with leukocyte migration/chemotaxis and MHC class II antigen presentation programs, implicating it in adaptive immune activation-related processes within the OA joint microenvironment."	0.1768
41689003	BMC musculoskeletal disorders	2026	Circular RNAs coordinate immunomodulation in osteoarthritic cartilage via antigen presentation and adaptive immune response.		hsa-UROS_0001	hsa_circ_UROS	UROS	osteoarthritis / OA	MONDO:0005178	osteoarthritis	down-regulated	RNA-seq	"hsa-UROS_0001 is downregulated in damaged OA cartilage and acts as a hub in the predicted ceRNA network, potentially maintaining extracellular matrix integrity by modulating ECM-related targets (e.g., COL11A2, ACAN, HAPLN1) and CHADL via miRNAs such as hsa-miR-5584-5p."	0.1768
41689003	BMC musculoskeletal disorders	2026	Circular RNAs coordinate immunomodulation in osteoarthritic cartilage via antigen presentation and adaptive immune response.		hsa-DAPK2_0010	hsa_circ_DAPK2	DAPK2	osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RNA-seq	"hsa-DAPK2_0010 is upregulated in damaged OA cartilage and is predicted to be a major ceRNA hub with extensive miRNA/mRNA interactions; its inferred downstream programs are enriched for ossification/cartilage calcification and immune regulation, with coexpression evidence suggesting a link to macrophage polarization-related gene LY96."	0.1768
41690268	"Clinics (Sao Paulo, Brazil)"	2026	Clinical significance and mechanistic role of Hsa_circ_0005075 in recurrent spontaneous abortion: Regulation of trophoblast proliferation and invasion through the Wnt/beta-catenin pathway.	hsa_circ_0005075				Recurrent Spontaneous Abortion / RSA	MONDO:0013727	"pregnancy loss, recurrent, susceptibility to, 1"	up-regulated	RT-qPCR	"hsa_circ_0005075 is up-regulated in serum from RSA patients and has diagnostic utility for RSA and related adverse outcomes. Functionally, its overexpression suppresses trophoblast proliferation and invasion, promotes apoptosis, and modulates cell-cycle distribution, at least partly by inhibiting Wnt/beta-catenin signaling (Wnt1/beta-catenin)."	0.6218
41715885	Biomarkers in medicine	2026	Novel circRNA signatures in cervical cancer: implications for early detection and screening.	hsa_circ_0123115	circ_0123115	hsa_circ_FGF12	FGF12	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RNA-seq	"circ_0123115 (FGF12-associated) is strongly upregulated in cancerous versus benign cervical tissues in this FFPE cohort and is proposed as a candidate biomarker for early detection/monitoring of cervical cancer. The study suggests it may relate to malignant transformation, but no functional mechanism was experimentally validated."	0.3991
41715885	Biomarkers in medicine	2026	Novel circRNA signatures in cervical cancer: implications for early detection and screening.	hsa_circ_0031011	circ_0031011	hsa_circ_DCUN1D2	DCUN1D2	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RNA-seq	circ_0031011 (DCUN1D2-associated) is upregulated in cancerous cervical tissues versus benign/precancerous tissues and is highlighted as a potentially novel biomarker. Mechanistic implications are discussed at a hypothesis level without experimental validation.	0.3991
41715885	Biomarkers in medicine	2026	Novel circRNA signatures in cervical cancer: implications for early detection and screening.	hsa_circ_0100775	circ_0100775	hsa_circ_TDRD3	TDRD3	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RNA-seq	"circ_0100775 (TDRD3-associated) is the top upregulated circRNA in benign versus precancerous cervical tissue comparison, suggesting utility as a stage-discriminating biomarker. No mechanistic experiments were reported."	0.3991
41715885	Biomarkers in medicine	2026	Novel circRNA signatures in cervical cancer: implications for early detection and screening.	hsa_circ_0006038	circ_0006038	hsa_circ_STXBP6	STXBP6	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RNA-seq	"circ_0006038 (STXBP6-associated) is the top upregulated circRNA in precancerous versus cancerous cervical tissue comparison, indicating potential utility for stage discrimination. No mechanistic or functional validation was performed."	0.3991
41715885	Biomarkers in medicine	2026	Novel circRNA signatures in cervical cancer: implications for early detection and screening.	hsa_circ_0106394	circ_0106394	hsa_circ_USP22	USP22	cervical cancer / CC	MONDO:0002974	cervical cancer	down-regulated	RNA-seq	"circ_0106394 (USP22-associated) shows progressive downregulation across cervical disease stages and is the top signal in the three-way comparison, suggesting potential value for tracking progression. Proposed functional relevance (e.g., proliferation/apoptosis/metabolic reprogramming) is discussed without experimental validation."	0.3991
41716226	Regenerative therapy	2026	Abnormal circ-CDK8 expression affects periodontitis development by regulating let-7b-5p/MAP4K3 signaling.		circ-CDK8	hsa_circ_CDK8	CDK8	Periodontitis	MONDO:0005076	periodontitis	up-regulated	RT-qPCR	"circ-CDK8 is upregulated in periodontitis tissues and functionally suppresses osteogenic differentiation of PDLSCs under inflammatory stimulation by promoting autophagy. It acts via a ceRNA mechanism, sponging let-7b-5p to regulate MAP4K3, and its inhibition enhances osteogenesis and reduces autophagy."	0.4249
41727546	Frontiers in pharmacology	2026	Danggui Niantong granules in the treatment of rheumatoid arthritis - a mechanistic approach using ceRNA networks.	hsa_circ_0083466		hsa_circ_ASAH1	ASAH1	rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	unknown	Microarray	"hsa_circ_0083466 was included in the representative circRNA-miRNA-mRNA ceRNA network constructed in DGNTG-treated MH7A RA model cells, and showed a moderate correlation with its host gene ASAH1."	0.1768
41727546	Frontiers in pharmacology	2026	Danggui Niantong granules in the treatment of rheumatoid arthritis - a mechanistic approach using ceRNA networks.	hsa_circ_0036303				rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	unknown	Microarray	"hsa_circ_0036303 was part of the representative ceRNA (circRNA-miRNA-mRNA) network proposed for DGNTG treatment effects in the MH7A rheumatoid arthritis cell model, without individual functional validation."	0.1768
41727546	Frontiers in pharmacology	2026	Danggui Niantong granules in the treatment of rheumatoid arthritis - a mechanistic approach using ceRNA networks.	hsa_circ_0036300				rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	unknown	Microarray	hsa_circ_0036300 was included in the representative DGNTG-associated ceRNA network in MH7A rheumatoid arthritis model cells; its specific downstream targets and functions were not experimentally validated.	0.1768
41727546	Frontiers in pharmacology	2026	Danggui Niantong granules in the treatment of rheumatoid arthritis - a mechanistic approach using ceRNA networks.	hsa_circ_0012134				rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	unknown	Microarray	hsa_circ_0012134 was one of the six circRNAs used to build the representative DGNTG-associated ceRNA network in MH7A rheumatoid arthritis model cells.	0.1768
41727546	Frontiers in pharmacology	2026	Danggui Niantong granules in the treatment of rheumatoid arthritis - a mechanistic approach using ceRNA networks.	hsa_circ_0060805				rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	unknown	Microarray	"hsa_circ_0060805 was used as one component of a representative DGNTG-associated circRNA-miRNA-mRNA network in MH7A rheumatoid arthritis model cells, without circRNA-specific experimental validation reported."	0.1768
41727546	Frontiers in pharmacology	2026	Danggui Niantong granules in the treatment of rheumatoid arthritis - a mechanistic approach using ceRNA networks.	hsa_circ_0066830				rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	dysregulated	RT-qPCR; Microarray	"hsa_circ_0066830 was identified as a DGNTG-responsive circRNA in MH7A rheumatoid arthritis model cells (supported by microarray and RT-qPCR), and was included in the representative ceRNA network constructed by the authors; direction of change was not stated in the provided text."	0.4032
41727546	Frontiers in pharmacology	2026	Danggui Niantong granules in the treatment of rheumatoid arthritis - a mechanistic approach using ceRNA networks.	hsa_circ_0013495				rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	dysregulated	RT-qPCR; Microarray	hsa_circ_0013495 was one of the circRNAs whose expression changes after DGNTG treatment in MH7A rheumatoid arthritis model cells were detected by microarray and validated by RT-qPCR; direction of change was not provided in the text.	0.1904
41727546	Frontiers in pharmacology	2026	Danggui Niantong granules in the treatment of rheumatoid arthritis - a mechanistic approach using ceRNA networks.	hsa_circ_0065740				rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	dysregulated	RT-qPCR; Microarray	"hsa_circ_0065740 showed DGNTG-associated expression changes in the MH7A rheumatoid arthritis cell model (microarray with RT-qPCR validation), but no specific mechanism or axis was reported for this circRNA."	0.1904
41727546	Frontiers in pharmacology	2026	Danggui Niantong granules in the treatment of rheumatoid arthritis - a mechanistic approach using ceRNA networks.	hsa_circ_0067728				rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	dysregulated	RT-qPCR; Microarray	"hsa_circ_0067728 exhibited DGNTG-associated expression changes in MH7A rheumatoid arthritis model cells, supported by microarray and confirmed by RT-qPCR; no specific downstream mechanism was experimentally established for this circRNA."	0.1904
41727546	Frontiers in pharmacology	2026	Danggui Niantong granules in the treatment of rheumatoid arthritis - a mechanistic approach using ceRNA networks.	hsa_circ_0077895				rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	dysregulated	RT-qPCR; Microarray	hsa_circ_0077895 was validated by RT-qPCR as being differentially expressed after DGNTG treatment in MH7A rheumatoid arthritis model cells; the article did not provide a specific ceRNA axis or functional assays for this circRNA.	0.1904
41757269	Frontiers in genetics	2026	Circ-104792/miR-133a/Bcl-xL influences the proliferation and function of human trophoblastic and decidual stromal cells involved in recurrent abortion disease.		circ-104792 / Homo-circ-104792			recurrent spontaneous abortion / RSA	MONDO:0013727	"pregnancy loss, recurrent, susceptibility to, 1"	down-regulated	RT-qPCR	"In RSA tissues (chorion and decidua), circ-104792 is down-regulated. Functionally, circ-104792 promotes proliferation and suppresses apoptosis in trophoblast (HTR-8/SVneo) and decidual stromal (HESC) cells by sponging miR-133a and thereby restoring Bcl-xL expression, partially rescuing miR-133a_induced cellular dysfunction."	0.7045
41758785	PloS one	2026	Comprehensive profiling of circRNAs reveals stimulus-specific networks and core regulators of cellular senescence.	hsa_circ_0000994				cellular senescence			down-regulated	RNA-seq	"hsa_circ_0000994 is consistently down-regulated in senescent (vs proliferating) WI38 and IMR90 human fibroblasts across senescence contexts, suggesting it may serve as a core senescence-associated circRNA marker."	0.1768
41758785	PloS one	2026	Comprehensive profiling of circRNAs reveals stimulus-specific networks and core regulators of cellular senescence.	hsa_circ_0000591				cellular senescence			down-regulated	RNA-seq	hsa_circ_0000591 is consistently down-regulated in senescent WI38 and IMR90 fibroblasts and is highlighted as a core/general senescence-associated circRNA candidate based on transcriptomic analyses.	0.1768
41758785	PloS one	2026	Comprehensive profiling of circRNAs reveals stimulus-specific networks and core regulators of cellular senescence.	hsa_circ_0072688				cellular senescence			down-regulated	RNA-seq	"hsa_circ_0072688 shows consistent down-regulation in senescent WI38 and IMR90 fibroblasts, marking it as a core senescence-associated circRNA candidate from RNA-seq-based analyses."	0.1768
41758785	PloS one	2026	Comprehensive profiling of circRNAs reveals stimulus-specific networks and core regulators of cellular senescence.	hsa_circ_0002111				cellular senescence			dysregulated	RNA-seq	"hsa_circ_0002111 shows cell line-dependent dysregulation during cellular senescence, increasing in WI38 but decreasing in IMR90, indicating context-dependent regulation in senescence programs."	0.1768
41760734	Experimental & molecular medicine	2026	A ESRP1/circPHGDH/miR-149/RAP1B positive feedback loop promotes the malignant behaviors and glycolysis of prostate cancer cell.	hsa_circ_0000121	circPHGDH / circ_0000121	hsa_circ_PHGDH	PHGDH	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	"circPHGDH is up-regulated in prostate cancer and promotes proliferation, migration, invasion, EMT, glycolysis, and in vivo tumor growth/metastasis. It functions as a ceRNA sponging miR-149 to upregulate RAP1B, which activates PI3K/AKT signaling. ESRP1 promotes circPHGDH biogenesis, and lactate-driven ESRP1 lactylation stabilizes ESRP1 to form a positive feedback loop."	0.8464
41769189	Biomedical reports	2026	Differentially expressed circular RNA profile in hemorrhagic and ischemic moyamoya disease.		circRNA-025016 / hsa_circRNA_025016			moyamoya disease	MONDO:0016820	Moyamoya disease	up-regulated	RT-qPCR; Microarray	"circRNA-025016 is significantly up-regulated in hemorrhagic MMD compared with ischemic MMD in whole venous blood, supported by microarray and RT-qPCR validation. Its mechanistic role was not experimentally defined in this study."	0.5135
41769189	Biomedical reports	2026	Differentially expressed circular RNA profile in hemorrhagic and ischemic moyamoya disease.		circRNA-104293 / hsa_circRNA_104293			moyamoya disease	MONDO:0016820	Moyamoya disease	up-regulated	RT-qPCR; Microarray	"circRNA-104293 is significantly up-regulated in hemorrhagic MMD compared with ischemic MMD in whole venous blood, supported by microarray and RT-qPCR validation. No specific miRNA targets or downstream mechanism were experimentally validated for this circRNA in the paper."	0.5135
41769189	Biomedical reports	2026	Differentially expressed circular RNA profile in hemorrhagic and ischemic moyamoya disease.		circRNA-060184 / hsa_circRNA_060184			moyamoya disease	MONDO:0016820	Moyamoya disease	up-regulated	RT-qPCR; Microarray	"circRNA-060184 is significantly up-regulated in hemorrhagic MMD versus ischemic MMD in whole venous blood, validated by RT-qPCR following microarray profiling. The study did not provide a circRNA-060184-specific miRNA/mRNA axis."	0.5135
41769189	Biomedical reports	2026	Differentially expressed circular RNA profile in hemorrhagic and ischemic moyamoya disease.		circRNA-091419 / hsa_circRNA_091419			moyamoya disease	MONDO:0016820	Moyamoya disease	up-regulated	RT-qPCR; Microarray	"circRNA-091419 is significantly up-regulated in hemorrhagic MMD relative to ischemic MMD in whole venous blood, validated by RT-qPCR after microarray screening. The study only performed predictive network analysis and did not experimentally validate a specific downstream axis for this circRNA."	0.5135
41769189	Biomedical reports	2026	Differentially expressed circular RNA profile in hemorrhagic and ischemic moyamoya disease.		circRNA-029937 / hsa_circRNA_029937			moyamoya disease	MONDO:0016820	Moyamoya disease	down-regulated	RT-qPCR; Microarray	"circRNA-029937 is significantly down-regulated in hemorrhagic MMD compared with ischemic MMD in whole venous blood, confirmed by RT-qPCR following microarray profiling. The paper did not experimentally validate a specific downstream mechanism for circRNA-029937."	0.5135
41769189	Biomedical reports	2026	Differentially expressed circular RNA profile in hemorrhagic and ischemic moyamoya disease.		circRNA-103574 / hsa_circRNA_103574			moyamoya disease	MONDO:0016820	Moyamoya disease	down-regulated	RT-qPCR; Microarray	"circRNA-103574 is significantly down-regulated in hemorrhagic MMD versus ischemic MMD in whole venous blood, validated by RT-qPCR after microarray profiling. No circRNA-103574-specific functional mechanism was experimentally demonstrated."	0.5135
41769189	Biomedical reports	2026	Differentially expressed circular RNA profile in hemorrhagic and ischemic moyamoya disease.		circRNA-103572 / hsa_circRNA_103572			moyamoya disease	MONDO:0016820	Moyamoya disease	down-regulated	RT-qPCR; Microarray	"circRNA-103572 is significantly down-regulated in hemorrhagic MMD compared with ischemic MMD in whole venous blood, validated by RT-qPCR after microarray screening. No direct functional or mechanistic experiments specific to circRNA-103572 were reported."	0.5135
41775938	Inflammation	2026	METTL3-Mediated m6A Regulation of CircINTS4/miR-146b-3p Axis in Rheumatoid Arthritis.	hsa_circ_0002476	circINTS4	hsa_circ_INTS4	INTS4	Rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	down-regulated	RT-qPCR; RNA-seq	"circINTS4 is significantly down-regulated in RA and acts as a protective circRNA. It sponges hsa-miR-146b-3p, thereby restraining RA-FLS proliferation/migration, promoting apoptosis, limiting M1 macrophage polarization, and reducing inflammatory cytokines. METTL3-mediated m6A modification decreases circINTS4 (via destabilization/degradation), and circINTS4 shows diagnostic potential (ROC AUC 0.902 for DAS28 activity)."	0.7761
41782876	Frontiers in immunology	2026	CircNF1 promotes gastric cancer metastasis by stabilizing HMGA2 mRNA through IGF2BP1 interaction.		circNF1	hsa_circ_NF1	NF1	Gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; ISH	"circNF1 is up-regulated in gastric cancer and is associated with poor prognosis. It promotes migration/EMT and lung metastasis by binding IGF2BP1 to stabilize HMGA2 mRNA, and its expression is increased via ZNF460-driven NF1 transcription."	0.8726
41787043	NPJ precision oncology	2026	Landscape of circular RNAs in acute myeloid leukemia and their clinical significance.	hsa_circ_0024048		hsa_circ_PIWIL4	PIWIL4	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RNA-seq	"In AML, hsa_circ_0024048 (PIWIL4-derived) shows higher expression in patients than healthy HSPCs and higher circRNA levels are associated with better overall survival. Its expression level also correlates with drug response, with Rucaparib showing better sensitivity in the high-expression group (validated in FIMM-AML)."	0.348
41787043	NPJ precision oncology	2026	Landscape of circular RNAs in acute myeloid leukemia and their clinical significance.	hsa_circ_0084678		hsa_circ_CSPP1	CSPP1	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RNA-seq	"In AML, hsa_circ_0084678 (CSPP1-derived) is higher in AML than healthy HSPCs and higher expression is linked to better overall survival (independent of host gene after adjustment). Its expression stratifies patients with improved sensitivity to multiple drugs, including Lenalidomide, validated across Beat-AML and FIMM-AML datasets."	0.348
41787043	NPJ precision oncology	2026	Landscape of circular RNAs in acute myeloid leukemia and their clinical significance.	hsa_circ_0080850		hsa_circ_PTPN12	PTPN12	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	unknown	RNA-seq	"hsa_circ_0080850 (PTPN12-derived) is a subgroup-specific prognostic marker in ELN2022 Favorable AML: high expression predicts poorer survival and markedly lower complete remission rates after induction therapy, with no corresponding prognostic signal from the host gene."	0.348
41787043	NPJ precision oncology	2026	Landscape of circular RNAs in acute myeloid leukemia and their clinical significance.			hsa_circ_FBXL5	FBXL5	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	unknown	RNA-seq	"This circRNA (FBXL5-derived; 4__15625252__15644657) was identified via RNA-seq as a subtype-associated prognostic circRNA in AML, reported to relate to poorer survival in the p53C subgroup, but the manuscript also notes lack of significant association in a supplementary analysis, making the prognostic direction uncertain overall."	0.348
41787043	NPJ precision oncology	2026	Landscape of circular RNAs in acute myeloid leukemia and their clinical significance.	hsa_circ_0085045		hsa_circ_STK3	STK3	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	unknown	RNA-seq	"hsa_circ_0085045 (STK3-derived) is a prognostic circRNA in the AML Splice molecular subtype, where higher expression is linked to poorer survival and is associated with complete remission status."	0.348
41787043	NPJ precision oncology	2026	Landscape of circular RNAs in acute myeloid leukemia and their clinical significance.	hsa_circ_0000558		hsa_circ_FOXN3	FOXN3	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	unknown	RNA-seq	hsa_circ_0000558 (FOXN3-derived) is a prognostic circRNA in the AML NPM1 subtype: higher expression indicates better survival and correlates with clinical features including complete remission and lower prevalence of FLT3 mutation.	0.348
41789656	International journal of molecular medicine	2026	Exosomal circ0000549 promotes MNNG_induced gastric cancer through miR_15b_5p/KIF1B.	hsa_circ_0000549	circ0000549 / circSRSF5	hsa_circ_SRSF5	SRSF5	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"Exosomal circ0000549 is up-regulated in MNNG-transformed gastric epithelial cells and in serum exosomes from GC patients with high nitrite exposure. It promotes proliferation, migration/invasion, EMT and stemness, and increases xenograft tumorigenicity by sponging miR-15b-5p to upregulate KIF1B and activate PI3K/AKT signaling."	0.8607
41800913	Current protocols	2026	Antisense Oligonucleotide Pulldown and Silencing of Circular RNA Nfix In Vivo in Neonatal Mouse Lungs.		circNfix	mmu_circ_Nfix	Nfix	Neonatal mouse lungs	MONDO:0005087	respiratory system disorder	up-regulated	RT-qPCR; RNA-seq	"In neonatal mouse lungs under hyperoxia (a neonatal disease model relevant to BPD), circNfix is reported as up-regulated and binds miR204-5p. circNfix acts as a sponge for miR204-5p, thereby affecting the miR204-5p target Ntrk2; GapmeR-mediated circNfix silencing reduces Ntrk2 expression."	0.7126
41809636	Non-coding RNA research	2026	Diagnostic potential of circular RNAs in carotid atherosclerotic plaque vulnerability.	hsa_circ_0006896	circVIRMA(3-4) / circKIAA1429	hsa_circ_VIRMA	VIRMA	carotid atherosclerotic plaque	MONDO:1060134	atherosclerotic cardiovascular disease	up-regulated	RT-qPCR	"circVIRMA(3-4) is up-regulated in PBMCs from patients with vulnerable carotid plaques and shows moderate ROC-based discrimination versus stable plaques. It was included in an in silico ceRNA network/pathway enrichment analysis, but no direct mechanistic validation was performed."	0.459
41809636	Non-coding RNA research	2026	Diagnostic potential of circular RNAs in carotid atherosclerotic plaque vulnerability.	hsa_circ_0044073	circGRN(12-13)	hsa_circ_GRN	GRN	carotid atherosclerotic plaque	MONDO:1060134	atherosclerotic cardiovascular disease	up-regulated	RT-qPCR	circGRN(12-13) is up-regulated in PBMCs from vulnerable carotid plaque patients and provides moderate ROC discrimination versus stable plaques. It was incorporated into an in silico ceRNA network/pathway enrichment analysis without direct mechanistic validation.	0.459
41809636	Non-coding RNA research	2026	Diagnostic potential of circular RNAs in carotid atherosclerotic plaque vulnerability.	hsa_circ_0001946	CDR1as(1) / CiRS7	hsa_circ_CDR1	CDR1	carotid atherosclerotic plaque	MONDO:1060134	atherosclerotic cardiovascular disease	up-regulated	RT-qPCR	"CDR1as(1) is strongly up-regulated in PBMCs from patients with vulnerable carotid plaques and provides the best ROC-based discrimination among tested circRNAs, supporting its biomarker potential. The paper discusses CDR1as as a hsa-miR-7 sponge and includes it in a hypothesis-generating ceRNA/pathway enrichment analysis."	0.459
41822169	Frontiers in cellular neuroscience	2026	CircFRRS1 drives neuroinflammation through the miR-27a-3p/TLR4 pathway after deep hypothermic circulatory arrest.	rno_circ_0028462	circFRRS1 / circ_0028462	rno_circ_FRRS1	FRRS1	DHCA-associated brain injury	MONDO:0005299	brain ischemia	up-regulated	RT-qPCR	"circFRRS1 is upregulated in DHCA rat hippocampus and aggravates DHCA-associated neuroinflammation and neuronal injury. It functions as a ceRNA by sponging miR-27a-3p, relieving repression of TLR4 and activating downstream TLR4/NF-kappaB/NLRP3 inflammatory signaling; circFRRS1 silencing is protective in vitro and in vivo."	0.6536
41835010	Frontiers in cellular and infection microbiology	2026	Longitudinal associations between PM2.5 with gestational diabetes mellitus mediated by gut microbiome and potential mechanism: based on a prospective pregnant women cohort in China.	hsa_circ_0001946				gestational diabetes mellitus / GDM	MONDO:0005406	gestational diabetes	up-regulated	RT-qPCR	"hsa_circ_0001946 is upregulated in plasma from pregnant women with GDM. The study also predicts that it may interact with RBPs including IGF2BP2/IGF2BP3, suggesting a potential insulin/IGF-related regulatory context."	0.348
41835010	Frontiers in cellular and infection microbiology	2026	Longitudinal associations between PM2.5 with gestational diabetes mellitus mediated by gut microbiome and potential mechanism: based on a prospective pregnant women cohort in China.	hsa_circ_0000154				gestational diabetes mellitus / GDM	MONDO:0005406	gestational diabetes	up-regulated	RT-qPCR	hsa_circ_0000154 is upregulated in plasma from pregnant women with GDM. It is included among GDM-associated circRNAs with predicted binding to the RBP EIF4A3.	0.348
41835010	Frontiers in cellular and infection microbiology	2026	Longitudinal associations between PM2.5 with gestational diabetes mellitus mediated by gut microbiome and potential mechanism: based on a prospective pregnant women cohort in China.	hsa_circ_0006732				gestational diabetes mellitus / GDM	MONDO:0005406	gestational diabetes	up-regulated	RT-qPCR	hsa_circ_0006732 is upregulated in plasma from GDM cases and is predicted (KEGG-based) to relate to insulin signaling/insulin response. CircInteractome prediction suggests RBP interactions including EIF4A3 and IGF2BP3.	0.348
41835010	Frontiers in cellular and infection microbiology	2026	Longitudinal associations between PM2.5 with gestational diabetes mellitus mediated by gut microbiome and potential mechanism: based on a prospective pregnant women cohort in China.	hsa_circ_0001016				gestational diabetes mellitus / GDM	MONDO:0005406	gestational diabetes	up-regulated	RT-qPCR	"hsa_circ_0001016 is upregulated in plasma from pregnant women with GDM and is included in CircInteractome-based predictions of RBP binding (e.g., EIF4A3; IGF2BP3)."	0.348
41835010	Frontiers in cellular and infection microbiology	2026	Longitudinal associations between PM2.5 with gestational diabetes mellitus mediated by gut microbiome and potential mechanism: based on a prospective pregnant women cohort in China.	hsa_circ_0001439				gestational diabetes mellitus / GDM	MONDO:0005406	gestational diabetes	up-regulated	RT-qPCR	"hsa_circ_0001439 is upregulated in plasma from GDM cases and is predicted (KEGG-based) to relate to insulin signaling/insulin response. CircInteractome predicts RBP binding, including EIF4A3 with binding sites in both flanking and junction regions."	0.348
41835010	Frontiers in cellular and infection microbiology	2026	Longitudinal associations between PM2.5 with gestational diabetes mellitus mediated by gut microbiome and potential mechanism: based on a prospective pregnant women cohort in China.	hsa_circ_0042852				gestational diabetes mellitus / GDM	MONDO:0005406	gestational diabetes	down-regulated	RT-qPCR	hsa_circ_0042852 is downregulated in plasma from pregnant women with GDM and is included among circRNAs with predicted EIF4A3 RBP binding.	0.348
41835010	Frontiers in cellular and infection microbiology	2026	Longitudinal associations between PM2.5 with gestational diabetes mellitus mediated by gut microbiome and potential mechanism: based on a prospective pregnant women cohort in China.	hsa_circ_0004001				gestational diabetes mellitus / GDM	MONDO:0005406	gestational diabetes	down-regulated	RT-qPCR	hsa_circ_0004001 is downregulated in plasma from pregnant women with GDM and is included among circRNAs with predicted EIF4A3 RBP binding.	0.348
41835010	Frontiers in cellular and infection microbiology	2026	Longitudinal associations between PM2.5 with gestational diabetes mellitus mediated by gut microbiome and potential mechanism: based on a prospective pregnant women cohort in China.	hsa_circ_0006936				gestational diabetes mellitus / GDM	MONDO:0005406	gestational diabetes	down-regulated	RT-qPCR	hsa_circ_0006936 is downregulated in plasma from pregnant women with GDM and is included among circRNAs with predicted EIF4A3 RBP binding.	0.348
41844577	Signal transduction and targeted therapy	2026	M6A-modified circArhgap26 attenuates cardiac ischemia_reperfusion injury by suppressing plakophilin-1 palmitoylation.		circArhgap26 / circRNA_018468 (circArhgap26)	hsa_circ_ARHGAP26	ARHGAP26	cardiac ischemia-reperfusion injury / cardiac I/R injury	MONDO:0005203	ischemia reperfusion injury	down-regulated	RT-qPCR; Microarray	"circArhgap26 is down-regulated in cardiac I/R injury and in plasma from PCI patients. It protects cardiomyocytes by binding PKP1 and disrupting PKP1_ZDHHC1 interaction, thereby reducing PKP1 palmitoylation/stability, lowering APAF1 translation, and inhibiting Caspase-9/Caspase-3-driven apoptosis. Its decreased circulating level suggests potential prognostic biomarker value."	0.8592
41844577	Signal transduction and targeted therapy	2026	M6A-modified circArhgap26 attenuates cardiac ischemia_reperfusion injury by suppressing plakophilin-1 palmitoylation.		circArhgap26 / circRNA_018468 (circArhgap26)	mmu_circ_Arhgap26	Arhgap26	cardiac ischemia-reperfusion injury / cardiac I/R injury	MONDO:0005203	ischemia reperfusion injury	down-regulated	RT-qPCR; Microarray	"circArhgap26 is down-regulated in cardiac I/R injury and in plasma from PCI patients. It protects cardiomyocytes by binding PKP1 and disrupting PKP1_ZDHHC1 interaction, thereby reducing PKP1 palmitoylation/stability, lowering APAF1 translation, and inhibiting Caspase-9/Caspase-3-driven apoptosis. Its decreased circulating level suggests potential prognostic biomarker value."	0.8592
41851080	Cell death & disease	2026	K48 and K63 linkage-competed ubiquitination of BECN1 promotes circPDE4D-mediated autophagy in chronic obstructive pulmonary disease.	hsa_circ_0072568	circPDE4D	hsa_circ_PDE4D	PDE4D	chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	down-regulated	RT-qPCR; RNA-seq	"circPDE4D is down-regulated in COPD and its lower level correlates with worse lung function. Functionally, circPDE4D promotes autophagy and stress granule formation while suppressing apoptosis and inflammatory cytokine release. Mechanistically, it sponges miR545-3p to upregulate SMURF1, enabling SMURF1 to enhance K63-linked (and reduce K48-linked) ubiquitination of BECN1 to stabilize BECN1 and support autophagy, forming a circPDE4D-miR545-3p-SMURF1-BECN1 feedback loop."	0.8685
41854933	"Cellular oncology (Dordrecht, Netherlands)"	2026	CircBARD1 suppresses tumor progression driven by H3K18 lactylation-CCNA2 axis in human bladder cancer.	hsa_circ_0058055	circBARD1	hsa_circ_BARD1	BARD1	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; Microarray	"In human bladder cancer, circBARD1 is down-regulated and acts as a tumor suppressor by inhibiting proliferation and migration. Mechanistically, circBARD1 binds ENO1 and promotes FBXW7-mediated ubiquitination/proteasomal degradation of ENO1, reducing glycolysis/lactate, suppressing H3K18 lactylation and thereby downregulating CCNA2 transcription, which limits tumor growth in vitro and in a xenograft model."	0.849
41864997	Cell death & disease	2026	Cancer-associated SF3B1 mutation suppresses DNA repair by disrupting the organization of nuclear actin network.		circATP9B	hsa_circ_ATP9B	ATP9B	cancer	MONDO:0004992	cancer	up-regulated	RT-qPCR; RNA-seq	"SF3B1-K700E mutation upregulates circATP9B. circATP9B binds MYH9 and promotes MYH9 ubiquitination/degradation, disrupting nuclear actin network formation and reducing HDR-associated DSB mobility/clustering, thereby impairing DNA repair and increasing olaparib sensitivity."	0.8058
41869307	Frontiers in immunology	2026	A mouse model of allergic conjunctivitis with mucosal immune-related gene and circRNA dysregulation.		Circ9626			Allergic conjunctivitis / AC	MONDO:0005642	atopic conjunctivitis	up-regulated	RT-qPCR; RNA-seq	"Circ9626 is up-regulated in conjunctival tissues in a ragweed pollen-induced mouse allergic conjunctivitis model and is positively co-expressed with IL-17 pathway genes (e.g., Tnfrsf4, Cxcl1, Lef1), suggesting a potential role in IL-17-associated inflammation."	0.4997
41869307	Frontiers in immunology	2026	A mouse model of allergic conjunctivitis with mucosal immune-related gene and circRNA dysregulation.		Circ2598			Allergic conjunctivitis / AC	MONDO:0005642	atopic conjunctivitis	up-regulated	RT-qPCR; RNA-seq	"Circ2598 is up-regulated in conjunctival tissues in a ragweed pollen-induced mouse allergic conjunctivitis model and is positively associated (co-expression) with IL-17 pathway genes, suggesting a role in IL-17-associated inflammation."	0.3684
41869307	Frontiers in immunology	2026	A mouse model of allergic conjunctivitis with mucosal immune-related gene and circRNA dysregulation.		Circ1004			Allergic conjunctivitis / AC	MONDO:0005642	atopic conjunctivitis	up-regulated	RT-qPCR; RNA-seq	"Circ1004 is significantly up-regulated in conjunctival tissues in a mouse allergic conjunctivitis model and shows positive co-expression with IL-17 pathway genes, implying potential involvement in IL-17-associated inflammatory regulation."	0.3684
41869307	Frontiers in immunology	2026	A mouse model of allergic conjunctivitis with mucosal immune-related gene and circRNA dysregulation.		Circ8687			Allergic conjunctivitis / AC	MONDO:0005642	atopic conjunctivitis	up-regulated	RT-qPCR; RNA-seq	"Circ8687 is up-regulated in conjunctival tissues in a mouse allergic conjunctivitis model and is part of an IL-17-gene co-expression network, suggesting potential involvement in IL-17-associated inflammation."	0.3684
41869307	Frontiers in immunology	2026	A mouse model of allergic conjunctivitis with mucosal immune-related gene and circRNA dysregulation.		Circ7049			Allergic conjunctivitis / AC	MONDO:0005642	atopic conjunctivitis	up-regulated	RT-qPCR; RNA-seq	"Circ7049 is up-regulated in conjunctival tissues in a mouse allergic conjunctivitis model and is positively co-expressed with IL-17 pathway genes, suggesting potential involvement in IL-17-associated inflammatory regulation."	0.3684
41869307	Frontiers in immunology	2026	A mouse model of allergic conjunctivitis with mucosal immune-related gene and circRNA dysregulation.		Circ0256			Allergic conjunctivitis / AC	MONDO:0005642	atopic conjunctivitis	up-regulated	RT-qPCR; RNA-seq	"Circ0256 is up-regulated in conjunctival tissues in a mouse allergic conjunctivitis model and is included among circRNAs positively correlated with IL-17 pathway genes, suggesting potential involvement in IL-17-associated inflammation."	0.3684
41869307	Frontiers in immunology	2026	A mouse model of allergic conjunctivitis with mucosal immune-related gene and circRNA dysregulation.		Circ4723			Allergic conjunctivitis / AC	MONDO:0005642	atopic conjunctivitis	up-regulated	RT-qPCR; RNA-seq	"Circ4723 is up-regulated in conjunctival tissues in a mouse allergic conjunctivitis model and is positively co-expressed with IL-17 pathway genes, suggesting it may be associated with IL-17-related inflammatory regulation in AC."	0.3684
41869354	Frontiers in immunology	2026	Silencing of circRERE(4-5) inhibits ONECUT2-mediated tumorigenesis and metastasis in gastric cancer.	hsa_circ_0009594	circRERE(4-5) / hsa_circRNA_100040	hsa_circ_RERE	RERE	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circRERE(4-5) is up-regulated in gastric cancer tissues/cells and in patient plasma, and higher plasma levels associate with tumor size and distant metastasis. Mechanistically, it acts as a ceRNA by sponging miR-571 to derepress ONECUT2, thereby promoting GC cell proliferation, migration, tumor growth and metastasis; ASO-mediated targeting suppresses xenograft growth and lung colonization."	0.8912
41876483	Cell death & disease	2026	BMSC-derived extracellular vesicles enhance osteosarcoma proliferation and metastasis via the circRNA-0010220/beta-catenin pathway.	hsa_circ_0010220	circRNA-0010220			osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; RNA-seq	"In osteosarcoma, BMSC-derived EVs deliver circRNA-0010220 into OS cells, where it localizes to the nucleus and binds EZH2. This promotes EZH2-mediated H3K27me3 at the CTNNBIP1 promoter, suppressing CTNNBIP1 and activating Wnt/beta-catenin signaling, thereby enhancing proliferation, migration/invasion, and metastasis."	0.8416
41879109	RNA biology	2026	Hsa_circ_0000711 can serve as a novel biomarker for primary biliary cholangitis by promoting disease progression through the regulation of miR-185-5p and NFATc3.	hsa_circ_0000711				primary biliary cholangitis / PBC	MONDO:0005388	primary biliary cholangitis	up-regulated	RT-qPCR	"hsa_circ_0000711 is up-regulated in PBC patient serum and in a GCDCA-induced HiBEpic PBC model. It promotes bile duct epithelial cell injury by sponging miR-185-5p and increasing NFATc3 expression, suggesting diagnostic biomarker potential."	0.7475
41891968	International journal of molecular medicine	2026	circOMA1 delivered by exosomes regulates DRD2_mediated prolactinoma resistance.	hsa_circ_0002316	circOMA1	hsa_circ_OMA1	OMA1	prolactin-secreting pituitary neuroendocrine tumours / PRL-PitNETs	MONDO:0010911	prolactin-producing pituitary gland adenoma	up-regulated	RT-qPCR; Microarray	"circOMA1 is upregulated in cabergoline-resistant PRL-PitNET and in patient plasma exosomes. It promotes and transmits cabergoline resistance by sponging miR-145-5p, increasing KBTBD7 to enhance DRD2 ubiquitination/degradation, thereby weakening cabergoline-induced autophagy and AKT inhibition; it also enhances tumor cell proliferation under cabergoline treatment."	0.871
41893670	Veterinary sciences	2026	Integrated Transcriptomics Reveals a SHEV ORF3-Mediated circRNA Network That Disrupts Riboflavin Metabolism and Activates the ko05212 Pathway.	hsa_circ_0077855	circRNA ENPP3 / circRNA13511	hsa_circ_ENPP3	ENPP3	Swine hepatitis E virus 	MONDO:0006011	viral hepatitis	up-regulated	RNA-seq	"In ORF3-overexpressing HepG2 cells, hsa_circ_0077855 (ENPP3-derived) is upregulated and is predicted to sponge miR-181a-2-3p/miR-30b-3p, de-repressing ENPP3 and KRAS. This links riboflavin metabolism disturbance to KRAS-driven pro-survival signaling (MAPK/ERK) in a predicted ceRNA network, without evidence of direct ORF3_circRNA binding from AlphaFold 3."	0.1768
41893670	Veterinary sciences	2026	Integrated Transcriptomics Reveals a SHEV ORF3-Mediated circRNA Network That Disrupts Riboflavin Metabolism and Activates the ko05212 Pathway.	hsa_circ_0130715	circRNA ENPP1	hsa_circ_ENPP1	ENPP1	Swine hepatitis E virus 	MONDO:0006011	viral hepatitis	down-regulated	RNA-seq	"In ORF3-overexpressing HepG2 cells, hsa_circ_0130715 (ENPP1-derived) is downregulated and is predicted to sponge miR-128-3p/miR-216a-3p less effectively. This is proposed to increase repression of ENPP1 and the tumor suppressor TP53 within a ceRNA network linked to riboflavin-metabolism disruption and pro-survival signaling."	0.1768
41893670	Veterinary sciences	2026	Integrated Transcriptomics Reveals a SHEV ORF3-Mediated circRNA Network That Disrupts Riboflavin Metabolism and Activates the ko05212 Pathway.	hsa_circ_0130711	circRNA ENPP1	hsa_circ_ENPP1	ENPP1	Swine hepatitis E virus 	MONDO:0006011	viral hepatitis	up-regulated	RNA-seq	"hsa_circ_0130711 is an ENPP1-derived circRNA reported to show an upregulation trend in ORF3-overexpressing HepG2 cells, but the study does not provide specific downstream miRNA/mRNA interactions or functional validation for this circRNA."	0.1768
41893670	Veterinary sciences	2026	Integrated Transcriptomics Reveals a SHEV ORF3-Mediated circRNA Network That Disrupts Riboflavin Metabolism and Activates the ko05212 Pathway.		ciRNA140			Swine hepatitis E virus 	MONDO:0006011	viral hepatitis	up-regulated	RNA-seq	"ciRNA140 (circRNA ENSG00000154269) is identified from RNA-seq as an upregulated circRNA in ORF3-overexpressing HepG2 cells within the riboflavin metabolism-focused screening, but no specific interaction targets or functional mechanisms are reported."	0.1768
41894117	Molecular biomedicine	2026	YTH N6-methyladenosine RNA binding protein 2 mediated m6A modification of circHIPK2 promotes cellular senescence and osteoarthritis progression by inhibiting autophagy.		circHIPK2	hsa_circ_HIPK2	HIPK2	osteoarthritis / OA	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR; ISH; RNA-seq	"circHIPK2 is down-regulated in osteoarthritis cartilage and acts as a chondroprotective circRNA. YTHDF2 recognizes m6A-modified circHIPK2 and promotes its degradation, weakening circHIPK2_RAB22A binding, enhancing RAB22A_PI3K interaction, activating PI3K_AKT_mTOR signaling, impairing autophagy, and accelerating chondrocyte senescence; restoring circHIPK2 (AAV or LNP delivery) alleviates OA progression in DMM mice."	0.8817
41894117	Molecular biomedicine	2026	YTH N6-methyladenosine RNA binding protein 2 mediated m6A modification of circHIPK2 promotes cellular senescence and osteoarthritis progression by inhibiting autophagy.	mmu_circ_0001468	circHIPK2	mmu_circ_HIPK2	HIPK2	osteoarthritis / OA	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR; ISH	"In the mouse DMM osteoarthritis model, mmu_circ_0001468 (circHIPK2) is reduced in cartilage, and restoring circHIPK2 in vivo alleviates senescence-associated OA phenotypes and disease progression."	0.5751
41897293	Biomolecules	2026	Evaluation of Plasma-Derived hsa_circ_003077 for Non-Invasive Diagnosis of Alzheimer's Disease.	hsa_circ_0030777	circ_0030777			Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR	"Plasma hsa_circ_003077 is significantly down-regulated in Alzheimer¡¯s disease patients versus healthy controls and shows strong diagnostic performance (AUC 0.90) for distinguishing AD from controls. The study reports only correlative associations with other plasma markers (e.g., GFAP and AXL) and does not establish a functional mechanism."	0.5261
41906003	Scientific reports	2026	CircFN1 modulates IL-1beta-induced osteoarthritis through the miR-19b-3p/PTEN signaling axis.	hsa_circ_0058152	circFN1 / hsa_circRNA_0058152	hsa_circ_FN1	FN1	osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; RNA-seq	"circFN1 is up-regulated in IL-1beta-induced OA chondrocyte model and functions as a pro-pathogenic circRNA. It sponges miR-19b-3p to suppress PTEN, thereby promoting apoptosis, inflammatory cytokine production, and ECM degradation while inhibiting chondrocyte proliferation."	0.6435
41907223	Non-coding RNA research	2026	Hsa_circ_0101645 contributes to excessive autophagy and apoptosis in intervertebral disc degeneration by acting as a miR-1304-5p sponge modulating BNIP3 expression.	hsa_circ_0101645		hsa_circ_AKAP6	AKAP6	intervertebral disc degeneration / IDD	MONDO:0011385	intervertebral disk degenerative disorder	up-regulated	RT-qPCR; Microarray	"hsa_circ_0101645 is up-regulated in IVDD endplate chondrocytes and mainly localizes to the cytoplasm. It promotes apoptosis and excessive autophagy and suppresses proliferation by sponging miR-1304-5p to increase BNIP3 expression, contributing to IVDD progression."	0.8355
41908224	Journal of Taibah University Medical Sciences	2026	"Evaluation of the circular RNA Pum1_0014, miRNA-146a, and miRNA-141-3p as biomarkers in PCOS."		circRNA Pum1_0014 / Pum1_0014	hsa_circ_PUM1	Pum1	polycystic ovary syndrome / PCOS	MONDO:0008487	polycystic ovary syndrome	down-regulated	RT-qPCR	"Serum circRNA Pum1_0014 is significantly decreased in women with PCOS and shows diagnostic value for early PCOS detection. The study proposes that circRNA Pum1_0014 may sponge miRNA-146a, linking this axis to hormonal/steroidogenesis-related imbalance in PCOS."	0.6238
41925956	Molecular biology reports	2026	"circFKBP8(5S,6)-encoded protein modulates alpha-synuclein expression in SH-SY5Y cells."	hsa_circ_0050119	"circFKBP8(5S,6)"	hsa_circ_FKBP8	FKBP8	Parkinson¡¯s disease / PD	MONDO:0005180	Parkinson disease	up-regulated	RT-qPCR	"In MPP_-treated SH-SY5Y cells (an in vitro PD model), circFKBP8(5S,6) is up-regulated. Manipulating its encoded protein cFKBP8 bidirectionally changes alpha-synuclein levels, supporting a positive regulatory role on alpha-synuclein expression/accumulation, while downstream pathways remain undefined."	0.3513
41926491	Breast cancer (Dove Medical Press)	2026	Identification of circRNA/lncRNA-miRNA-Transcription Factor-mRNA Networks to Identify Potential Biomarkers in Response to Neoadjuvant Therapy for Breast Cancer.		circRNA_31003			breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	"circRNA_31003 is upregulated in pre-therapy breast cancer tumor tissues versus adjacent normal tissues and decreases after NAT. It is proposed to act in a ceRNA network by sponging miR-661 and miR-143-5p to modulate NKX2-2/NEK2 and PRAME/RAD54L axes, potentially contributing to tumorigenesis and NAT response."	0.4032
41926491	Breast cancer (Dove Medical Press)	2026	Identification of circRNA/lncRNA-miRNA-Transcription Factor-mRNA Networks to Identify Potential Biomarkers in Response to Neoadjuvant Therapy for Breast Cancer.		circRNA_42276			breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	"circRNA_42276 is upregulated in pre-therapy breast cancer tumor tissues versus adjacent normal tissues and decreases after NAT. It is proposed to function in a ceRNA axis (circRNA_42276/MIAT_miR-1225-3p_HOXC11_CCL5), suggesting relevance to tumor biology and NAT responsiveness."	0.4032
41929494	Frontiers in immunology	2026	Comprehensive circRNA profiling of platelets and exosomes identifies hsa_circ_0061274 as a novel biomarker for lung adenocarcinoma.	hsa_circ_0061274				lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; RNA-seq	"This study identified platelet hsa_circ_0061274 as significantly down-regulated in LUAD and validated it by RT-qPCR in independent cohorts. It showed diagnostic utility for distinguishing LUAD from healthy donors and benign pulmonary nodules (including stage I disease), but no functional mechanism was experimentally established."	0.5963
41940034	Non-coding RNA research	2026	CircSMAD4 shapes matrix-remodeling TAMs in lung adenocarcinoma.	hsa_circ_0047713	circSMAD4	hsa_circ_SMAD4	SMAD4	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"In LUAD tumor-associated macrophages, circSMAD4 is up-regulated and drives a protumor, matrix-remodeling M2-like program. It acts in the cytoplasm as a ceRNA to sponge miR-562 and de-repress COL4A1, and also scaffolds the m6A reader IGF2BP2 to stabilize m6A-marked transcripts (COL4A1, ACTA2, SPI1), thereby promoting tumor growth, invasion/EMT, and metastasis."	0.8988
25689795	Clinica chimica acta; international journal of clinical chemistry	2015	Using circular RNA as a novel type of biomarker in the screening of gastric cancer.	hsa_circ_0000140	hsa_circ_002059	hsa_circ_KIAA0907	KIAA0907	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"This study identified hsa_circ_002059, also listed as hsa_circ_0000140 in CircBase, as significantly down-regulated in gastric cancer tissues compared with adjacent nontumorous tissues. Its expression was also different between preoperative and postoperative plasma samples, correlated with clinicopathological features including TNM stage and distal metastasis, and showed diagnostic potential with an ROC AUC of 0.73. No mechanistic regulatory axis or functional pathway was experimentally investigated."	0.6238
26600397	Cancer biomarkers : section A of Disease markers	2016	Hsa_circ_0001649: A circular RNA and potential novel biomarker for hepatocellular carcinoma.	hsa_circ_0001649	hsa_circ_001599	hsa_circ_SHPRH	SHPRH	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"This study found that hsa_circ_0001649, a SHPRH-derived circRNA, is significantly downregulated in HCC tissues compared with paired adjacent liver tissues. Low hsa_circ_0001649 expression was associated with tumor size, tumor embolus, metastasis-related MMP expression, and poor prognosis, suggesting a potential tumor-suppressive role in HCC invasion/metastasis and value as a diagnostic biomarker."	0.6846
26657152	Oncogene	2016	Foxo3 activity promoted by non-coding effects of circular RNA and Foxo3 pseudogene in the inhibition of tumor growth and angiogenesis.		circular Foxo3 / hsa_circRNA_104170	hsa_circ_FOXO3	Foxo3	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Northern Blot	"In this study, circ-Foxo3 is a Foxo3-derived circular RNA that is lower in breast tumor/cancer contexts than in normal tissues or non-cancer cell lines. Ectopic circ-Foxo3 suppresses breast cancer cell proliferation/survival and xenograft tumor growth, promotes apoptosis, reduces CD34-associated vascularization, and inhibits local invasion. Mechanistically, circ-Foxo3 acts as a sponge for eight miRNAs, relieving repression of Foxo3 mRNA translation and increasing Foxo3 protein expression."	0.78
27404501	Biomarkers in medicine	2016	hsa_circRNA_103636: potential novel diagnostic and therapeutic biomarker in Major depressive disorder.		hsa_circRNA_002143			major depressive disorder / MDD	MONDO:0002009	major depressive disorder	up-regulated	RT-qPCR; Microarray	hsa_circRNA_002143 was identified as an up-regulated circRNA in PBMCs from MDD patients and was validated as significantly different between MDD patients and healthy controls by RT-PCR. No specific molecular mechanism or interacting partners were reported for this circRNA.	0.4773
27404501	Biomarkers in medicine	2016	hsa_circRNA_103636: potential novel diagnostic and therapeutic biomarker in Major depressive disorder.		hsa_circRNA_103636			major depressive disorder / MDD	MONDO:0002009	major depressive disorder	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_103636 was down-regulated in PBMCs from MDD patients and was the only validated circRNA significantly altered after 8 weeks of antidepressant treatment. The study proposed it as a potential diagnostic and therapeutic biomarker for MDD, with predicted interactions with five miRNAs."	0.5963
27404501	Biomarkers in medicine	2016	hsa_circRNA_103636: potential novel diagnostic and therapeutic biomarker in Major depressive disorder.		hsa_circRNA_100679			major depressive disorder / MDD	MONDO:0002009	major depressive disorder	down-regulated	RT-qPCR; Microarray	hsa_circRNA_100679 was identified as a down-regulated circRNA in PBMCs from MDD patients and was validated as significantly different between MDD patients and healthy controls by RT-PCR. No specific molecular mechanism or interacting partners were reported for this circRNA.	0.4773
27404501	Biomarkers in medicine	2016	hsa_circRNA_103636: potential novel diagnostic and therapeutic biomarker in Major depressive disorder.		hsa_circRNA_104953			major depressive disorder / MDD	MONDO:0002009	major depressive disorder	down-regulated	RT-qPCR; Microarray	hsa_circRNA_104953 was identified as a down-regulated circRNA in PBMCs from MDD patients and was validated as significantly different between MDD patients and healthy controls by RT-PCR. No specific molecular mechanism or interacting partners were reported for this circRNA.	0.4773
27470294	Journal of neurochemistry	2016	Characterization of circular RNAs landscape in multiple system atrophy brain.	hsa_circ_0038374	IQCK	hsa_circ_IQCK	IQCK	multiple system atrophy / MSA	MONDO:0007803	multiple system atrophy	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0038374, referred to as IQCK, was identified by RNA-seq and validated by RNase R-assisted RT-qPCR as up-regulated in human MSA frontal cortex. Its overexpression was particularly evident in white matter, suggesting disease-associated circRNA transcriptome perturbation and potential biomarker relevance."	0.5135
27470294	Journal of neurochemistry	2016	Characterization of circular RNAs landscape in multiple system atrophy brain.		MAP4K3 / hsa_circ_00054211	hsa_circ_MAP4K3	MAP4K3	multiple system atrophy / MSA	MONDO:0007803	multiple system atrophy	up-regulated	RT-qPCR; RNA-seq	"The MAP4K3 circRNA was identified by RNA-seq and validated by RNase R-assisted RT-qPCR as up-regulated in human MSA frontal cortex. It was significantly up-regulated in MSA white matter and also in grey matter compared with controls, supporting its relevance to MSA-associated circRNA dysregulation."	0.5135
27470294	Journal of neurochemistry	2016	Characterization of circular RNAs landscape in multiple system atrophy brain.	hsa_circ_0032891	EFCAB11	hsa_circ_EFCAB11	EFCAB11	multiple system atrophy / MSA	MONDO:0007803	multiple system atrophy	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0032891, referred to as EFCAB11, was identified by RNA-seq and validated by RNase R-assisted RT-qPCR as up-regulated in human MSA frontal cortex. The study described it as a 193-nt circRNA formed from backspliced exons 4-5 and found its overexpression in MSA white matter."	0.5135
27470294	Journal of neurochemistry	2016	Characterization of circular RNAs landscape in multiple system atrophy brain.	hsa_circ_0108308	DTNA	hsa_circ_DTNA	DTNA	multiple system atrophy / MSA	MONDO:0007803	multiple system atrophy	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0108308, referred to as DTNA, was identified by RNA-seq and validated by RNase R-assisted RT-qPCR as up-regulated in human MSA frontal cortex. It was described as a 363-nt circRNA composed of exons 3-5 and was overexpressed in MSA white matter."	0.5135
27470294	Journal of neurochemistry	2016	Characterization of circular RNAs landscape in multiple system atrophy brain.	hsa_circ_0005540	MCTP1	hsa_circ_MCTP1	MCTP1	multiple system atrophy / MSA	MONDO:0007803	multiple system atrophy	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005540, referred to as MCTP1, was identified by RNA-seq and validated by RNase R-assisted RT-qPCR as up-regulated in human MSA frontal cortex. It was the largest differentially expressed circRNA among the five validated candidates and was significantly up-regulated in both MSA white matter and grey matter."	0.5135
27614453	Journal of cancer research and clinical oncology	2017	The circular RNA ciRS-7 (Cdr1as) acts as a risk factor of hepatic microvascular invasion in hepatocellular carcinoma.		ciRS-7 / CDR1 as	hsa_circ_CDR1AS	CDR1 as	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"This study found that ciRS-7 was not significantly different overall between paired HCC and non-tumor tissues, but elevated ciRS-7 in HCC was associated with MVI and other aggressive clinicopathological features. ciRS-7 was identified as an independent risk factor and potential predictive biomarker for hepatic MVI, possibly acting through miR-7 sequestration and disruption of the PIK3CD/p70S6K/mTOR pathway."	0.7081
27886165	Cell death and differentiation	2017	Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity.		circ-Foxo3	hsa_circ_FOXO3	FOXO3	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Northern Blot	"circ-Foxo3 is down-regulated in breast carcinoma biopsies and cancer cell lines but increases during apoptosis. Functionally, circ-Foxo3 promotes stress-induced apoptosis and suppresses tumor growth by binding MDM2 and p53, enhancing p53 ubiquitination while protecting Foxo3 from MDM2-mediated degradation, leading to increased Puma expression."	0.8229
27886165	Cell death and differentiation	2017	Induction of tumor apoptosis through a circular RNA enhancing Foxo3 activity.		circ-Foxo3	mmu_circ_Foxo3	Foxo3	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Northern Blot	"circ-Foxo3 is down-regulated in breast carcinoma biopsies and cancer cell lines but increases during apoptosis. Functionally, circ-Foxo3 promotes stress-induced apoptosis and suppresses tumor growth by binding MDM2 and p53, enhancing p53 ubiquitination while protecting Foxo3 from MDM2-mediated degradation, leading to increased Puma expression."	0.8229
27986464	Cancer letters	2017	Circular RNA profile identifies circPVT1 as a proliferative factor and prognostic marker in gastric cancer.		circPVT1	hsa_circ_PVT1	PVT1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"circPVT1 is a PVT1-derived human circRNA that is frequently upregulated in gastric cancer tissues, partly due to genomic DNA amplification at its locus. It promotes gastric cancer cell proliferation by functioning as a cytoplasmic miRNA sponge, especially for the miR-125 family, with downstream effects including E2F2 and possibly c-Myc regulation. Clinically, higher circPVT1 expression is associated with better OS and DFS and serves as an independent prognostic marker in gastric cancer."	0.8647
28062277	Biochimica et biophysica acta. Molecular basis of disease	2017	"Circ100284, via miR-217 regulation of EZH2, is involved in the arsenite-accelerated cell cycle of human keratinocytes in carcinogenesis."		circ100284	hsa_circ_GCLM	GCLM	skin oncogenesis	MONDO:0002898	skin cancer	up-regulated	RT-qPCR; Microarray	"circ100284 is up-regulated in arsenite-treated and arsenite-transformed human HaCaT keratinocytes. It functions as a miR-217 sponge to increase EZH2, leading to up-regulation of cyclin D1/CDK4, acceleration of the G1/S cell-cycle transition, and enhanced malignant transformation phenotypes including colony formation, invasion, and migration."	0.7328
28089832	Cancer letters	2017	Androgen receptor (AR) promotes clear cell renal cell carcinoma (ccRCC) migration and invasion via altering the circHIAT1/miR-195-5p/29a-3p/29c-3p/CDC42 signals.		hsa_circ_001013 / circHIAT1	hsa_circ_HIAT1	HIAT1	clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	down-regulated	RT-qPCR	"circHIAT1 is down-regulated in ccRCC and is further lower in metastatic disease. AR represses circHIAT1 by transcriptionally regulating the HIAT1 host gene, and reduced circHIAT1 destabilizes miR-195-5p/miR-29a-3p/miR-29c-3p, increasing CDC42 signaling to promote migration, invasion and metastasis. Higher circHIAT1 expression is associated with better overall survival, supporting its role as a metastasis suppressor and potential biomarker/therapeutic target."	0.859
28103507	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2017	"Circular BANP, an upregulated circular RNA that modulates cell proliferation in colorectal cancer."		circ-BANP	hsa_circ_BANP	BANP	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; Microarray	"circ-BANP is a BANP-derived circular RNA upregulated in colorectal cancer tissues and CRC cell lines. Functional knockdown experiments showed that circ-BANP promotes CRC cell proliferation and colony formation, possibly through activation of the PI3K/Akt pathway as reflected by reduced p-Akt after circ-BANP silencing. The study suggests circ-BANP may be a potential diagnostic and therapeutic marker for CRC."	0.741
28130019	Clinica chimica acta; international journal of clinical chemistry	2017	Using circular RNA hsa_circ_0000190 as a new biomarker in the diagnosis of gastric cancer.	hsa_circ_0000190		hsa_circ_CNIH4	CNIH4	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"This study evaluated hsa_circ_0000190 as a clinical biomarker for gastric cancer. hsa_circ_0000190 was down-regulated in gastric cancer tissues and patient plasma, and its expression was associated with several clinicopathological factors and showed diagnostic value by ROC analysis."	0.5662
28184940	Oncology reports	2017	Circular RNA and gene expression profiles in gastric cancer based on microarray chip technology.		hsa_circRNA_400071			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	hsa_circRNA_400071 was identified as up-regulated in gastric cancer tissues compared with adjacent tissues and validated by qRT-PCR. The study suggests that differentially expressed circRNAs may regulate gastric cancer development through circRNA-miRNA-mRNA interactions and may serve as future biomarkers.	0.5135
28184940	Oncology reports	2017	Circular RNA and gene expression profiles in gastric cancer based on microarray chip technology.		hsa_circRNA_000792			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	hsa_circRNA_000792 was identified as up-regulated in gastric cancer tissues compared with adjacent tissues and showed significant qRT-PCR validation. The study proposes that differentially expressed circRNAs may act through circRNA-miRNA-mRNA regulation and may have biomarker potential in gastric cancer.	0.5135
28184940	Oncology reports	2017	Circular RNA and gene expression profiles in gastric cancer based on microarray chip technology.		hsa_circRNA_000543			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	Microarray	"hsa_circRNA_000543 was selected as an up-regulated circRNA from the microarray screen, but its qRT-PCR validation was not significant. Therefore, its gastric cancer association is supported only at low confidence, and no specific functional mechanism was experimentally demonstrated beyond the proposed circRNA-miRNA-mRNA regulatory model."	0.5135
28184940	Oncology reports	2017	Circular RNA and gene expression profiles in gastric cancer based on microarray chip technology.		hsa_circRNA_001959			gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	hsa_circRNA_001959 was identified as down-regulated in gastric cancer tissues and validated by qRT-PCR. The article links differentially expressed circRNAs to potential circRNA-miRNA-mRNA regulatory mechanisms in gastric cancer and suggests biomarker potential.	0.5135
28184940	Oncology reports	2017	Circular RNA and gene expression profiles in gastric cancer based on microarray chip technology.		hsa_circRNA_400066			gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	hsa_circRNA_400066 was selected as a down-regulated circRNA in gastric cancer tissues and had a significant qRT-PCR result. The study did not define a circRNA-specific functional phenotype but proposed a broader circRNA-miRNA-mRNA regulatory role in gastric cancer.	0.5135
28184940	Oncology reports	2017	Circular RNA and gene expression profiles in gastric cancer based on microarray chip technology.		hsa_circRNA_001066			gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	hsa_circRNA_001066 was identified as down-regulated in gastric cancer tissues compared with adjacent tissues and showed significant qRT-PCR validation. The study suggests that such dysregulated circRNAs may contribute to gastric cancer through miRNA-mediated regulation of target mRNAs.	0.5135
28276108	Cell biology international	2017	CircRNA hsa_circ_0005105 upregulates NAMPT expression and promotes chondrocyte extracellular matrix degradation by sponging miR-26a.	hsa_circ_0005105				Osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"hsa_circ_0005105 is up-regulated in IL-1beta-stimulated human chondrocytes used as an osteoarthritis-related model. It sponges miR-26a and upregulates NAMPT, thereby promoting extracellular matrix degradation and inflammatory mediator production, suggesting a potential therapeutic target for OA."	0.5416
28296235	The FEBS journal	2017	The circular RNA ciRS-7 promotes APP and BACE1 degradation in an NF-kappaB-dependent manner.		circular RNA sponge for miR-7 / ciRS-7	hsa_circ_CDR1NAT		Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR	"This study identifies ciRS-7 as a regulator of AD-related APP and BACE1 protein abundance. ciRS-7 promotes APP and BACE1 degradation through proteasomal and lysosomal pathways by suppressing NF-jB/p65 translation and nuclear activity, thereby increasing UCHL1 expression; this reduces Ab40/Ab42 generation and suggests a neuroprotective therapeutic potential in AD."	0.5223
28343871	"Pathology, research and practice"	2017	Over-expression of CircRNA_100876 in non-small cell lung cancer and its prognostic value.		CircRNA_100876 / circRNA-CER	hsa_circ_RNF121	RNF121	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"This study found that circRNA 100876 is significantly up-regulated in NSCLC tumor tissues compared with adjacent nontumorous tissues. Higher expression correlates with lymph node metastasis, advanced tumor stage, and shorter overall survival, supporting its potential value as a poor-prognosis biomarker in NSCLC. The mechanistic role was not experimentally defined in this paper."	0.4758
28349836	Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine	2017	Identification of differentially expressed circular RNAs in human colorectal cancer.		hsa_circRNA_103809	hsa_circ_ZFR	ZFR	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	hsa_circRNA_103809 was significantly down-regulated in colorectal cancer tissues and its lower expression was associated with lymph node metastasis and TNM stage. The study suggests that it may serve as a diagnostic biomarker and may function through a putative circRNA-miRNA sponge mechanism.	0.6556
28349836	Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine	2017	Identification of differentially expressed circular RNAs in human colorectal cancer.		hsa_circRNA_104700	hsa_circ_PTK2	PTK2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	hsa_circRNA_104700 was significantly down-regulated in colorectal cancer tissues and its lower expression was associated with distal metastasis. The study suggests that it may serve as a diagnostic biomarker and may function through a putative circRNA-miRNA sponge mechanism.	0.6556
28412345	Biochemical and biophysical research communications	2017	"A novel identified circular RNA, circRNA_010567, promotes myocardial fibrosis via suppressing miR-141 by targeting TGF-beta1."		circRNA_010567			myocardial fibrosis	MONDO:0005267	heart disorder	up-regulated	RT-qPCR; Microarray	"circRNA_010567 is up-regulated in diabetic mouse myocardium and Ang II-treated cardiac fibroblasts. It promotes myocardial fibrosis by negatively regulating miR-141 and increasing TGF-beta1-associated fibrotic responses, including Col I, Col III and alpha-SMA expression. Silencing circRNA_010567 suppresses cardiac fibroblast viability and alleviates fibrosis-associated protein synthesis."	0.6777
28443463	Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine	2017	Decreased expression of hsa_circ_0001895 in human gastric cancer and its clinical significances.	hsa_circ_0001895	hsa_circ_000760	hsa_circ_PRRC2B	PRRC2B	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"This study found that hsa_circ_0001895 is significantly down-regulated in gastric cancer cell lines, gastric cancer tissues, and gastric dysplasia tissues. Its expression is associated with clinicopathological factors including cell differentiation, Borrmann type, and tissue CEA expression, and ROC analysis supports its potential diagnostic value. The article proposes hsa_circ_0001895 as a potential biomarker for gastric cancer screening and prognosis prediction, but does not define a specific molecular mechanism."	0.6238
28493512	Journal of clinical laboratory analysis	2018	Decreased expression of hsa_circ_0003570 in hepatocellular carcinoma and its clinical significance.	hsa_circ_0003570		hsa_circ_FAM53B	FAM53B	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"This study showed that hsa_circ_0003570 is significantly down-regulated in HCC cell lines and HCC tissues, with expression decreasing across CH, LC, and HCC. Its reduced expression is associated with clinicopathological features of HCC and may have clinical relevance as a biomarker, especially for distinguishing LC from CH, although mechanistic function was not experimentally validated."	0.63
28498369	Cell death and differentiation	2017	Circular RNA mediates cardiomyocyte death via miRNA-dependent upregulation of MTP18 expression.		mitochondrial fission and apoptosis-related circRNA / mm9circ-016597	mmu_circ_Smyd4	Smyd4	myocardial infarction / MI	MONDO:0005068	myocardial infarction	up-regulated	RT-qPCR	"MFACR is a mouse circRNA derived from Smyd4 that is up-regulated in cardiomyocytes under A/R and in mouse heart tissue after I/R injury. It acts as a cytoplasmic sponge for miR-652-3p, relieving miR-652-3p-mediated repression of MTP18 and thereby promoting mitochondrial fission, cardiomyocyte apoptosis, and myocardial infarction; MFACR knockdown attenuates these pathological effects."	0.7785
28520103	"Hepatology (Baltimore, Md.)"	2017	Circular RNA circMTO1 acts as the sponge of microRNA-9 to suppress hepatocellular carcinoma progression.	hsa_circ_0007874	circMTO1 / hsa_circRNA_104135	hsa_circ_MTO1	MTO1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; ISH; Microarray	"circMTO1 is significantly downregulated in human HCC tissues, and reduced expression is associated with poor patient prognosis. Functionally, circMTO1 acts as a tumor suppressor by sponging oncogenic miR-9, thereby promoting p21 expression and inhibiting HCC proliferation, invasion, and in vivo tumor growth while enhancing apoptosis."	0.7875
28534714	"Clinical and experimental hypertension (New York, N.Y. : 1993)"	2017	Profiling and bioinformatics analyses reveal differential circular RNA expression in hypertensive patients.	hsa_circ_0005870				hypertension	MONDO:0005044	hypertensive disorder	down-regulated	RT-qPCR; Microarray	"hsa-circ-0005870 was significantly down-regulated in plasma/peripheral blood from hypertensive patients and was validated by qRT-PCR. The study proposes hsa-circ-0005870 as a potential diagnostic biomarker for hypertension and predicts a hsa-circ-0005870-miRNA-mRNA regulatory network involving five miRNAs and 849 mRNAs, with enrichment in processes including cellular response to stress and TGF-beta signaling."	0.4032
28608528	Journal of cellular biochemistry	2018	Overexpression of Circular RNA ciRS-7 Abrogates the Tumor Suppressive Effect of miR-7 on Gastric Cancer via PTEN/PI3K/AKT Signaling Pathway.		Cdr1as / ciRS-7	hsa_circ_CDR1	CDR1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"ciRS-7 is upregulated in gastric cancer and correlates with advanced clinicopathologic features and poor survival. Functionally, it acts as a miR-7 sponge to relieve miR-7-mediated suppression of PTEN/PI3K/AKT signaling, thereby promoting malignant behaviors such as proliferation, migration, invasion, and tumor growth while reducing apoptosis."	0.6589
28618205	Journal of clinical laboratory analysis	2018	Reduced expression of circRNA hsa_circ_0003159 in gastric cancer and its clinical significance.	hsa_circ_0003159				gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0003159 is significantly down-regulated in gastric cancer tissues compared with adjacent non-tumorous tissues. Its lower expression is associated with distal metastasis and TNM stage, and ROC analysis suggests potential diagnostic biomarker value for gastric cancer."	0.5662
28618429	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2017	Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients.		circRNA_092516			rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; Microarray	"circRNA_092516 was identified by microarray and validated by qRT-PCR as significantly elevated in PBMCs from RA patients. The study suggests altered circRNA expression may be related to RA pathogenesis, but circRNA_092516 was not reported as a diagnostic ROC-positive biomarker and was not correlated with disease severity measures."	0.3588
28618429	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2017	Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients.		circRNA_003524			rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; Microarray	"circRNA_003524 was identified by microarray and validated by qRT-PCR as significantly elevated in PBMCs from RA patients. ROC analysis indicated diagnostic value for distinguishing RA patients from healthy controls, but its expression was not associated with disease severity measures."	0.4679
28618429	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2017	Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients.		circRNA_103047			rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; Microarray	"circRNA_103047 was identified by microarray and validated by qRT-PCR as significantly elevated in PBMCs from RA patients. ROC analysis indicated diagnostic value for distinguishing RA patients from healthy controls, and its level correlated with circRNA_003524, although no mechanistic interaction was tested."	0.4679
28618429	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2017	Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients.		circRNA_104871			rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; Microarray	"circRNA_104871 was identified by microarray and validated by qRT-PCR as significantly elevated in PBMCs from RA patients. It showed the strongest diagnostic performance among the reported circRNAs, suggesting high potential as a non-invasive RA diagnostic biomarker, but no disease-severity correlation was observed."	0.4679
28618429	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2017	Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Rheumatoid Arthritis Patients.		circRNA_101873			rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR; Microarray	"circRNA_101873 was identified by microarray and validated by qRT-PCR as significantly elevated in PBMCs from RA patients. ROC analysis indicated diagnostic value for distinguishing RA patients from healthy controls, but its expression was not associated with disease severity measures."	0.4679
28622299	Cell death and differentiation	2017	A circular RNA promotes tumorigenesis by inducing c-myc nuclear translocation.	hsa_circ_0004214	circ-Amotl1	hsa_circ_Amotl1		breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Northern Blot	"circ-Amotl1 is up-regulated in breast carcinoma biopsies and cancer cell lines. It promotes tumorigenic phenotypes including proliferation, survival, colony formation, invasion, angiogenesis and xenograft tumor formation while inhibiting apoptosis. Mechanistically, circ-Amotl1 binds c-myc, promotes its nuclear translocation/retention and stability, and enhances c-myc target gene expression."	0.8557
28639908	Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine	2017	Circular RNAs play an important role in late-stage gastric cancer: Circular RNA expression profiles and bioinformatics analyses.	hsa_circ_0058246				gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0058246 was identified in this study as an up-regulated circRNA in advanced gastric cancer specimens and was validated by real-time PCR. Its elevated expression was associated with poor clinical outcomes, greater lymph node invasion, and recurrence, suggesting potential clinical relevance in advanced gastric cancer progression."	0.5047
28651352	Human molecular genetics	2017	Circular RNA profiling reveals that circular RNAs from ANXA2 can be used as new biomarkers for multiple sclerosis.	hsa_circ_0005402	circ_0005402	hsa_circ_ANXA2	ANXA2	multiple sclerosis / MS	MONDO:0005301	multiple sclerosis	down-regulated	RT-qPCR; Microarray	"circ_0005402 is a human ANXA2-derived circRNA that is significantly downregulated in peripheral blood from RR-MS patients. Its expression showed biomarker potential for RR-MS with a significant ROC AUC of 0.899, and bioinformatic analysis predicted miRNA and RBP binding sites."	0.6841
28651352	Human molecular genetics	2017	Circular RNA profiling reveals that circular RNAs from ANXA2 can be used as new biomarkers for multiple sclerosis.	hsa_circ_0035560	circ_0035560 / hsa_circ_0003452_2	hsa_circ_ANXA2	ANXA2	multiple sclerosis / MS	MONDO:0005301	multiple sclerosis	down-regulated	RT-qPCR; Microarray	"circ_0035560, renamed circ_0003452_2 by the authors after Sanger sequencing revealed a different junction structure, is a human ANXA2-derived circRNA significantly downregulated in RR-MS blood. It was proposed as a new biomarker for multiple sclerosis, with ROC AUC 0.706, and bioinformatic analysis suggested shared miRNA regulation with circ_0005402."	0.6841
28656881	Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine	2017	Low expression of hsa_circ_0006633 in human gastric cancer and its clinical significances.	hsa_circ_0006633				gastric cancer / GC	MONDO:0001056	gastric cancer	dysregulated	RT-qPCR; Microarray	"This study identifies hsa_circ_0006633 as a dysregulated circRNA in gastric cancer: it is downregulated in gastric cancer tissues and cell lines but increased in plasma from gastric cancer patients. Low tissue expression is associated with distal metastasis and tissue CEA level, and the authors propose hsa_circ_0006633 as a potential biomarker for gastric cancer screening."	0.6663
28676412	Journal of molecular and cellular cardiology	2017	Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease.		circSLC8A1	hsa_circ_SLC8A1		dilated cardiomyopathy / DCM	MONDO:0005021	dilated cardiomyopathy	up-regulated	RT-qPCR	"circSLC8A1 was significantly increased relative to its host gene expression in DCM heart samples compared with non-failing controls. Homolog-based RIP analyses also suggested association with ribosomes and Argonaute 2, implying a possible role in translation regulation."	0.2995
28676412	Journal of molecular and cellular cardiology	2017	Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease.		circCHD7	hsa_circ_CHD7	CHD7	dilated cardiomyopathy / DCM	MONDO:0005021	dilated cardiomyopathy	up-regulated	RT-qPCR	"circCHD7 was significantly increased relative to its host gene expression in DCM heart samples compared with non-failing controls. The study reports this as a disease-associated expression change, without direct functional mechanistic validation for circCHD7."	0.2995
28676412	Journal of molecular and cellular cardiology	2017	Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease.		circATXN10	hsa_circ_ATXN10		dilated cardiomyopathy / DCM	MONDO:0005021	dilated cardiomyopathy	up-regulated	RT-qPCR	circATXN10 was increased relative to host gene expression in DCM samples and was selected as the most significant candidate among the tested disease-associated circRNAs. Its DCM association was confirmed by RT-qPCR in an independent human heart biopsy panel.	0.2995
28676412	Journal of molecular and cellular cardiology	2017	Identification of circular RNAs with host gene-independent expression in human model systems for cardiac differentiation and disease.		circDNAJ6C	hsa_circ_DNAJ6C	DNAJ6C	dilated cardiomyopathy / DCM	MONDO:0005021	dilated cardiomyopathy	down-regulated	RT-qPCR	circDNAJ6C/circDNA6JC was significantly decreased relative to host gene expression in DCM heart samples compared with non-failing controls. The study reports this as a DCM-associated expression change but does not provide direct functional mechanistic validation for this circRNA.	0.2995
28683453	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2017	Effect of Circular ANRIL on the Inflammatory Response of Vascular Endothelial Cells in a Rat Model of Coronary Atherosclerosis.		Circular ANRIL / circular antisense non-coding RNA at the INK4 locus	rno_circ_ANRIL	ANRIL	coronary atherosclerosis	MONDO:0021661	coronary atherosclerosis	up-regulated	RT-qPCR	"This study investigates cANRIL in a vitamin D3/high-fat diet-induced rat model of coronary atherosclerosis. Elevated cANRIL aggravates vascular endothelial inflammation and apoptosis, increases inflammatory factors and adverse lipid parameters, and promotes AS, while cANRIL inhibition has protective effects."	0.5358
28685964	The FEBS journal	2017	hsa_circ_0013958: a circular RNA and potential novel biomarker for lung adenocarcinoma.	hsa_circ_0013958	circ_0013958	hsa_circ_ACP6	ACP6	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0013958 is up-regulated in LAC tissues, cell lines and plasma, and its expression is associated with TNM stage and lymphatic metastasis. Functionally, it promotes proliferation, migration and invasion while inhibiting apoptosis in LAC cells. Mechanistically, cytoplasmic hsa_circ_0013958 sponges miR-134 and up-regulates oncogenic CCND1/cyclin D1, supporting its value as a potential non-invasive biomarker for LAC detection."	0.8419
28687357	Cancer letters	2017	Circular RNA MYLK as a competing endogenous RNA promotes bladder cancer progression through modulating VEGFA/VEGFR2 signaling pathway.		circRNA-MYLK	hsa_circ_MYLK	MYLK	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circRNA-MYLK is upregulated in bladder carcinoma and its high expression correlates with advanced clinicopathological features and poor survival. It promotes BC proliferation, migration, invasion, angiogenesis, EMT, xenograft growth and metastasis by sponging miR-29a, increasing VEGFA, and activating VEGFA/VEGFR2 and downstream Ras/ERK signaling."	0.8743
28695771	Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine	2017	MicroRNA-200b suppresses the invasion and migration of hepatocellular carcinoma by downregulating RhoA and circRNA_000839.		circRNA_000839 / circ_000839			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_000839 was identified as a predicted miR-200b target circRNA and was significantly up-regulated in HCC tissues compared with normal liver tissues. Its expression was negatively correlated with miR-200b and positively correlated with RhoA, supporting a proposed miR-200b-mediated endogenous competition model involving circ_000839 and RhoA, although the direct functional role of circ_000839 in HCC invasion or migration was not tested."	0.348
28695772	Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine	2017	"Circular RNA GLI2 promotes osteosarcoma cell proliferation, migration, and invasion by targeting miR-125b-5p."	hsa_circ_0056288	circRNA GLI2	hsa_circ_GLI2	GLI2	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"cir-GLI2/hsa_circ_0056288 is upregulated in osteosarcoma tissues and cell lines and functions as an oncogenic circRNA. Mechanistically, it acts as a ceRNA/miRNA sponge that negatively targets miR-125b-5p, thereby promoting proliferation, migration, and invasion while inhibiting apoptosis in OS cells. The study suggests cir-GLI2 may be a diagnostic and therapeutic target for osteosarcoma."	0.7519
28707774	Cell biology international	2017	"Hsa_circ_0020397 regulates colorectal cancer cell viability, apoptosis and invasion by promoting the expression of the miR-138 targets TERT and PD-L1."	hsa_circ_0020397	circ_0020397	hsa_circ_DOCK1	DOCK1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"hsa_circ_0020397 is up-regulated in colorectal cancer cells. It acts as a miR-138 sponge to inhibit miR-138 function and increase expression of the miR-138 targets TERT and PD-L1, thereby promoting CRC cell viability and invasion while inhibiting apoptosis."	0.5607
28765045	Biochemical and biophysical research communications	2017	Androgen-responsive circular RNA circSMARCA5 is up-regulated and promotes cell proliferation in prostate cancer.		circSMARCA5 / Circular SMARCA5	hsa_circ_SMARCA5	SMARCA5	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circ-SMARCA5 is a human SMARCA5-derived circRNA up-regulated in prostate cancer tissues and cell lines. It is androgen-inducible and functions as an oncogenic circRNA by promoting proliferation and cell cycle progression while inhibiting apoptosis, suggesting potential diagnostic and therapeutic relevance in PCa."	0.5751
28774651	Gene	2017	Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation.	hsa_circ_0071410				radiation-induced liver fibrosis / RILF	MONDO:0043459	radiation-induced disorder	up-regulated	RT-qPCR; Microarray	"hsa_circ_0071410 is up-regulated in irradiated human hepatic stellate cells. Functional assays show that its knockdown increases miR-9-5p, reduces LX2 proliferation and alpha-SMA expression, and attenuates irradiation-induced HSC activation, suggesting a pro-fibrotic role in RILF."	0.5804
28774651	Gene	2017	Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation.	hsa_circ_0072765				radiation-induced liver fibrosis / RILF	MONDO:0043459	radiation-induced disorder	up-regulated	RT-qPCR; Microarray	"hsa_circ_0072765 is significantly up-regulated in irradiated LX2 hepatic stellate cells and was validated by qRT-PCR. Bioinformatic analysis predicts that it may bind miR-370, suggesting a potential circRNA/miRNA regulatory role in RILF."	0.3858
28774651	Gene	2017	Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation.	hsa_circ_0054345				radiation-induced liver fibrosis / RILF	MONDO:0043459	radiation-induced disorder	up-regulated	RT-qPCR; Microarray	"hsa_circ_0054345 is significantly up-regulated in irradiated LX2 hepatic stellate cells and was validated by qRT-PCR. Bioinformatic analysis predicts that it may bind miR-33a, suggesting a potential circRNA/miRNA regulatory role in RILF."	0.3858
28774651	Gene	2017	Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation.	hsa_circ_0070963				radiation-induced liver fibrosis / RILF	MONDO:0043459	radiation-induced disorder	down-regulated	RT-qPCR; Microarray	"hsa_circ_0070963 is significantly down-regulated in irradiated LX2 hepatic stellate cells and was validated by qRT-PCR. Bioinformatic analysis predicts that it may bind miR-22-3p, suggesting a potential circRNA/miRNA regulatory role in RILF."	0.3858
28774651	Gene	2017	Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation.	hsa_circ_0061893				radiation-induced liver fibrosis / RILF	MONDO:0043459	radiation-induced disorder	down-regulated	RT-qPCR; Microarray	"hsa_circ_0061893 is significantly down-regulated in irradiated LX2 hepatic stellate cells and was validated by qRT-PCR. Bioinformatic analysis predicts that it may interact with miR-483-5p, suggesting a potential circRNA/miRNA regulatory role in RILF."	0.3858
28774651	Gene	2017	Microarray profiling of circular RNAs and the potential regulatory role of hsa_circ_0071410 in the activated human hepatic stellate cell induced by irradiation.	hsa_circ_0013255				radiation-induced liver fibrosis / RILF	MONDO:0043459	radiation-induced disorder	down-regulated	RT-qPCR; Microarray	"hsa_circ_0013255 is significantly down-regulated in irradiated LX2 hepatic stellate cells and was validated by qRT-PCR. Bioinformatic analysis predicts that it may bind miR-182-5p, suggesting a potential circRNA/miRNA regulatory role in RILF."	0.3858
28786753	Autophagy	2017	Circular RNA HIPK2 regulates astrocyte activation via cooperation of autophagy and ER stress by targeting MIR124-2HG.		circular RNA HIPK2 / circHIPK2	hsa_circ_HIPK2	HIPK2	astrocyte activation	MONDO:0000001	disease	up-regulated	RT-qPCR; ISH	"circHIPK2 is up-regulated in methamphetamine-treated astrocytes and functions as a MIR124-2HG sponge. By inhibiting MIR124-2HG, circHIPK2 increases SIGMAR1 expression and promotes astrocyte activation through coordinated regulation of autophagy and ER stress. In vivo, circHIPK2 knockdown in mouse hippocampi attenuates methamphetamine- and LPS-induced astrocyte activation, suggesting therapeutic potential in drug abuse-related and neuroinflammatory conditions."	0.717
28786753	Autophagy	2017	Circular RNA HIPK2 regulates astrocyte activation via cooperation of autophagy and ER stress by targeting MIR124-2HG.		circular RNA HIPK2 / circHIPK2	mmu_circ_Hipk2	HIPK2	astrocyte activation	MONDO:0000001	disease	up-regulated	RT-qPCR; ISH	"circHIPK2 is up-regulated in methamphetamine-treated astrocytes and functions as a MIR124-2HG sponge. By inhibiting MIR124-2HG, circHIPK2 increases SIGMAR1 expression and promotes astrocyte activation through coordinated regulation of autophagy and ER stress. In vivo, circHIPK2 knockdown in mouse hippocampi attenuates methamphetamine- and LPS-induced astrocyte activation, suggesting therapeutic potential in drug abuse-related and neuroinflammatory conditions."	0.717
28794202	EMBO reports	2017	CircHIPK3 sponges miR-558 to suppress heparanase expression in bladder cancer cells.	hsa_circ_0000284	circHIPK3 / bladder cancer-related circular RNA-2 (BCRC-2)	hsa_circ_HIPK3	HIPK3	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"circHIPK3/hsa_circ_0000284 is a human HIPK3-derived circRNA that is down-regulated in bladder cancer tissues and cell lines. It suppresses bladder cancer migration, invasion, angiogenesis, tumor growth, and metastasis by sponging miR-558 and reducing HPSE expression and downstream MMP-9/VEGF activity. Clinically, lower circHIPK3 expression is associated with higher grade, invasion, and lymph node metastasis, suggesting potential therapeutic relevance."	0.8426
28795385	Human cell	2017	"Hsa_circ_0045714 regulates chondrocyte proliferation, apoptosis and extracellular matrix synthesis by promoting the expression of miR-193b target gene IGF1R."	hsa_circ_0045714				osteoarthritis / OA	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR	"This study shows that hsa_circ_0045714 is downregulated in OA cartilage and acts as a protective circRNA in chondrocytes. It sponges miR-193b to relieve repression of IGF1R, thereby promoting chondrocyte proliferation and ECM synthesis while inhibiting apoptosis."	0.6479
28798046	"Science (New York, N.Y.)"	2017	Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function.		Cdr1as			schizophrenia / SZ	MONDO:0005090	schizophrenia	unknown	RT-qPCR; Northern Blot; ISH	"This study shows that Cdr1as is a neuron-enriched mammalian circRNA required for normal brain function. Genetic deletion of the Cdr1as locus in mice deregulates miR-7 and miR-671, induces up-regulation of immediate early genes, disrupts excitatory synaptic transmission, and produces a prepulse inhibition deficit relevant to neuropsychiatric disorders."	0.668
28798046	"Science (New York, N.Y.)"	2017	Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function.		Cdr1as			schizophrenia / SZ	MONDO:0005090	schizophrenia	unknown	RT-qPCR; Northern Blot; ISH	"This study shows that Cdr1as is a neuron-enriched mammalian circRNA required for normal brain function. Genetic deletion of the Cdr1as locus in mice deregulates miR-7 and miR-671, induces up-regulation of immediate early genes, disrupts excitatory synaptic transmission, and produces a prepulse inhibition deficit relevant to neuropsychiatric disorders."	0.668
28803498	Epigenomics	2017	Screening circular RNA related to chemotherapeutic resistance in breast cancer.	hsa_circ_0006528	circ 0006528	hsa_circ_PRELID2	PRELID2	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	This circRNA is upregulated in Adriamycin-resistant breast cancer tissues and cell lines and contributes to chemoresistance. It likely functions as a miRNA sponge in the circ 0006528 / miR-7-5p / Raf1 axis; silencing circ 0006528 increases ADM sensitivity and reduces Raf1 expression.	0.6676
28817829	Ophthalmic research	2017	Altered Expression Profile of Circular RNAs in the Serum of Patients with Diabetic Retinopathy Revealed by Microarray.		hsa_circRNA_100192			diabetic retinopathy / DR	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR; Microarray	"This circRNA was significantly upregulated in serum from T2DR patients compared with T2DM and control subjects. The study suggests it may contribute to diabetic retinopathy pathogenesis and may be useful as a potential therapeutic biomarker, likely through a miRNA-related mechanism involving miR-146."	0.3401
28846924	Molecular immunology	2017	The circular RNA of peripheral blood mononuclear cells: Hsa_circ_0005836 as a new diagnostic biomarker and therapeutic target of active pulmonary tuberculosis.	hsa_circ_0005836	circ_0005836			active tuberculosis	MONDO:0100481	active tuberculosis	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005836 was significantly down-regulated in PBMCs from APTB patients and was validated by qRT-PCR in a larger cohort. The study proposes it as a potential diagnostic biomarker and possible therapeutic target for TB infection, with predicted involvement in circRNA-miRNA-mRNA regulatory networks."	0.4685
28846924	Molecular immunology	2017	The circular RNA of peripheral blood mononuclear cells: Hsa_circ_0005836 as a new diagnostic biomarker and therapeutic target of active pulmonary tuberculosis.	hsa_circ_0009128	circ_0009128			active tuberculosis	MONDO:0100481	active tuberculosis	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0009128 was reported as decreased in PBMCs of APTB patients and was further assessed by qRT-PCR in a larger clinical cohort. Although discussed as a potential biomarker candidate, the authors noted that it was not effective for diagnosis in the larger cohort."	0.4685
28846924	Molecular immunology	2017	The circular RNA of peripheral blood mononuclear cells: Hsa_circ_0005836 as a new diagnostic biomarker and therapeutic target of active pulmonary tuberculosis.	hsa_circ_0023956	circ_0023956			active tuberculosis	MONDO:0100481	active tuberculosis	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0023956 was one of six differentially expressed circRNAs selected from circRNA sequencing and tested by qRT-PCR. It was significantly decreased in PBMCs of APTB patients in the initial validation cohort, but the study did not further establish its diagnostic value or specific molecular mechanism."	0.4685
28860123	Circulation	2017	Circular Noncoding RNA HIPK3 Mediates Retinal Vascular Dysfunction in Diabetes Mellitus.	hsa_circ_0000284	circHIPK3 / circular HIPK3	hsa_circ_HIPK3	HIPK3	Diabetes mellitus / DM	MONDO:0005015	diabetes mellitus	up-regulated	RT-qPCR; Northern Blot	"circHIPK3 is a HIPK3-derived circRNA conserved in human and mouse and is upregulated in diabetic retinas, diabetic patient fibrovascular membranes, plasma, and aqueous humor. It promotes retinal endothelial proliferation, migration, tube formation, vascular leakage, inflammation, and retinal vascular dysfunction by acting as a cytoplasmic sponge for miR-30a-3p and increasing VEGFC, FZD4, and WNT2 expression. Silencing circHIPK3 alleviates diabetes mellitus-induced retinal vascular dysfunction in vivo, suggesting therapeutic relevance."	0.8626
28860123	Circulation	2017	Circular Noncoding RNA HIPK3 Mediates Retinal Vascular Dysfunction in Diabetes Mellitus.	mmu_circ_0001052	circHIPK3 / circular HIPK3	mmu_circ_HIPK3	HIPK3	Diabetes mellitus / DM	MONDO:0005015	diabetes mellitus	up-regulated	RT-qPCR; Northern Blot	"circHIPK3 is a HIPK3-derived circRNA conserved in human and mouse and is upregulated in diabetic retinas, diabetic patient fibrovascular membranes, plasma, and aqueous humor. It promotes retinal endothelial proliferation, migration, tube formation, vascular leakage, inflammation, and retinal vascular dysfunction by acting as a cytoplasmic sponge for miR-30a-3p and increasing VEGFC, FZD4, and WNT2 expression. Silencing circHIPK3 alleviates diabetes mellitus-induced retinal vascular dysfunction in vivo, suggesting therapeutic relevance."	0.8626
28864418	Biochemical and biophysical research communications	2017	The expression profiles of circRNAs in lung tissues from rats with lipopolysaccharide-induced acute respiratory distress syndrome: A microarray study.		mmu_circRNA_19423			acute respiratory distress syndrome / ARDS	MONDO:0006502	acute respiratory distress syndrome	up-regulated	RT-qPCR; Microarray	"mmu_circRNA_19423 was significantly up-regulated in lung tissues from LPS-induced ARDS rats and validated by qRT-PCR. The study suggests it may serve as a potential ARDS biomarker or therapeutic target, with predicted miRNA-related ceRNA involvement, but no direct mechanistic or functional validation was performed."	0.6157
28864418	Biochemical and biophysical research communications	2017	The expression profiles of circRNAs in lung tissues from rats with lipopolysaccharide-induced acute respiratory distress syndrome: A microarray study.		rno_circRNA_010489 / rno_-circRNA_010489			acute respiratory distress syndrome / ARDS	MONDO:0006502	acute respiratory distress syndrome	up-regulated	RT-qPCR; Microarray	"rno_circRNA_010489 was significantly up-regulated in LPS-induced ARDS rat lung tissues and validated by qRT-PCR. The authors predicted miRNA targets and hypothesized that it may act as a miRNA sponge during ARDS, although this mechanism requires future confirmation."	0.6157
28864418	Biochemical and biophysical research communications	2017	The expression profiles of circRNAs in lung tissues from rats with lipopolysaccharide-induced acute respiratory distress syndrome: A microarray study.		rno_circRNA_011426 / rno_-circRNA_011426			acute respiratory distress syndrome / ARDS	MONDO:0006502	acute respiratory distress syndrome	up-regulated	RT-qPCR; Microarray	"rno_circRNA_011426 was significantly up-regulated in lung tissues from LPS-induced ARDS rats and validated by qRT-PCR. It was included among the validated circRNAs with predicted miRNA targets, suggesting potential biomarker or therapeutic relevance, but no direct functional mechanism was confirmed."	0.6157
28864418	Biochemical and biophysical research communications	2017	The expression profiles of circRNAs in lung tissues from rats with lipopolysaccharide-induced acute respiratory distress syndrome: A microarray study.		mmu_circRNA_30664			acute respiratory distress syndrome / ARDS	MONDO:0006502	acute respiratory distress syndrome	up-regulated	RT-qPCR; Microarray	"mmu_circRNA_30664 was significantly up-regulated in lung tissues from LPS-induced ARDS rats and validated by qRT-PCR. The study suggests possible biomarker or therapeutic-target potential and predicted miRNA interactions, but did not experimentally validate a downstream mechanism."	0.6157
28864418	Biochemical and biophysical research communications	2017	The expression profiles of circRNAs in lung tissues from rats with lipopolysaccharide-induced acute respiratory distress syndrome: A microarray study.		rno_circRNA_005564			acute respiratory distress syndrome / ARDS	MONDO:0006502	acute respiratory distress syndrome	down-regulated	RT-qPCR; Microarray	"rno_circRNA_005564 was significantly down-regulated in LPS-induced ARDS rat lung tissues and validated by qRT-PCR. It was one of five validated differentially expressed circRNAs with predicted miRNA targets and potential biomarker or therapeutic relevance, although mechanistic function was not experimentally tested."	0.6157
28892615	Journal of proteome research	2017	Quantitative Proteomics Reveals the Regulatory Networks of Circular RNA CDR1as in Hepatocellular Carcinoma Cells.		CDR1as / ciRS-7			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; ISH	"This study reports that CDR1as is downregulated in HCC tissues and cell lines, but gain-of-function experiments show that CDR1as promotes HCC cell proliferation, cell-cycle progression, and adhesion while reducing migration. Mechanistically, CDR1as suppresses miR-7 and increases EGFR expression, forming a CDR1as/miR-7/EGFR regulatory axis that contributes to proliferation and cell-cycle effects in HCC cells."	0.6835
28933584	DNA and cell biology	2017	Circular RNA hsa_circ_0001982 Promotes Breast Cancer Cell Carcinogenesis Through Decreasing miR-143.	hsa_circ_0001982		hsa_circ_RNF111	RNF111	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001982 is up-regulated in breast cancer tissues and cell lines and was validated by qRT-PCR after microarray screening. Functionally, it promotes breast cancer cell proliferation and invasion while inhibiting apoptosis. Mechanistically, it acts as a miR-143 sponge in a ceRNA-like mechanism, and knockdown effects are rescued by miR-143 inhibition."	0.7785
28940688	Journal of clinical laboratory analysis	2018	Clinical values of circular RNA 0000181 in the screening of gastric cancer.	hsa_circ_0000181		hsa_circ_TATDN3	TATDN3	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"This study found that hsa_circ_0000181 is significantly down-regulated in gastric cancer tissues and in plasma from gastric cancer patients. Its expression is associated with several clinicopathologic features, and ROC analyses suggest potential diagnostic value as a tissue- and plasma-based biomarker for gastric cancer."	0.5261
28957794	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2017	Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma.		hsa_circRNA_103801			osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_103801 is up-regulated in osteosarcoma cell lines and tissues. The study predicts that it may function as an oncogenic ceRNA by interacting with hsa-miR-370-3p, hsa-miR-338-3p and hsa-miR-877-3p, with TANC1 as a correlated downstream ceRNA partner. Bioinformatics analyses linked it to HIF-1, VEGF/angiogenesis, Rap1 and PI3K-Akt-related pathways, suggesting potential diagnostic or therapeutic relevance."	0.4032
28957794	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2017	Microarray Expression Profile and Functional Analysis of Circular RNAs in Osteosarcoma.		hsa_circRNA_104980			osteosarcoma / OS	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_104980 is down-regulated in osteosarcoma cell lines and tissues. The study suggests it may act as a tumor suppressor circRNA and predicts a circRNA/miRNA/mRNA regulatory network involving hsa-miR-1298-3p, hsa-miR-660-3p and the correlated downstream partner NFATC2IP. Bioinformatics analyses associated it with tight junction and immune/cytokine-related pathways, but the authors note that further validation is needed."	0.4032
28958934	Biochemical and biophysical research communications	2017	Cinnamaldehyde induces cell apoptosis mediated by a novel circular RNA hsa_circ_0043256 in non-small cell lung cancer.	hsa_circ_0043256				non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	dysregulated	RT-qPCR; Microarray	"This study identifies hsa_circ_0043256 as a cinnamaldehyde-responsive circular RNA in NSCLC models. hsa_circ_0043256 inhibits proliferation and promotes apoptosis by acting as a miR-1252 sponge, increasing ITCH expression and suppressing Wnt/beta-catenin signaling. Its knockdown weakens cinnamaldehyde-induced apoptosis and tumor-growth inhibition, supporting its role in cinnamaldehyde-mediated anti-tumor activity."	0.7283
28980874	"Cell cycle (Georgetown, Tex.)"	2017	"Analysis of co-expression networks for circular RNAs and mRNAs reveals that circular RNAs hsa_circ_0047905, hsa_circ_0138960 and has-circRNA7690-15 are candidate oncogenes in gastric cancer."	hsa_circ_0047905	circRNA0047905	hsa_circ_SERPINB5	SERPINB5	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0047905/circRNA0047905 is significantly up-regulated in gastric cancer tissues and preferentially localized in the cytoplasm of AGS cells. Its knockdown suppresses AGS cell proliferation and invasion, and it positively correlates with and regulates the parental gene SERPINB5. It also shows diagnostic potential for GC, with the highest reported AUC among the three circRNAs studied."	0.7444
28980874	"Cell cycle (Georgetown, Tex.)"	2017	"Analysis of co-expression networks for circular RNAs and mRNAs reveals that circular RNAs hsa_circ_0047905, hsa_circ_0138960 and has-circRNA7690-15 are candidate oncogenes in gastric cancer."	hsa_circ_0138960	circRNA0138960	hsa_circ_GDA	GDA	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0138960/circRNA0138960 is significantly up-regulated in gastric cancer tissues and preferentially localized in the cytoplasm of AGS cells. Its knockdown suppresses AGS cell proliferation and invasion, and its expression positively correlates with GDA mRNA. It shows modest diagnostic value for GC based on ROC analysis."	0.7364
28980874	"Cell cycle (Georgetown, Tex.)"	2017	"Analysis of co-expression networks for circular RNAs and mRNAs reveals that circular RNAs hsa_circ_0047905, hsa_circ_0138960 and has-circRNA7690-15 are candidate oncogenes in gastric cancer."		circRNA7690-15	hsa_circ_GDA	GDA	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"has-circRNA7690-15/circRNA7690-15 is significantly up-regulated in gastric cancer tissues and preferentially localized in the cytoplasm of AGS cells. Its knockdown suppresses AGS cell proliferation and invasion, supporting a tumor-promoting role, although it did not positively correlate with GDA mRNA in GC tissues. It shows modest diagnostic value for GC based on ROC analysis."	0.7364
28990083	Molecular medicine reports	2017	Confirmation and preliminary analysis of circRNAs potentially involved in human intervertebral disc degeneration.	hsa_circ_0008305	circ_0008305			human intervertebral disc degeneration / IDD	MONDO:0011385	intervertebral disk degenerative disorder	up-regulated	RT-qPCR; Microarray	"hsa_circ_0008305 was identified from circRNA expression profiling and experimentally validated by RT-qPCR as significantly upregulated in degenerative disc samples. The study suggests it may be potentially involved in IDD, but no specific molecular mechanism was determined."	0.4032
28990083	Molecular medicine reports	2017	Confirmation and preliminary analysis of circRNAs potentially involved in human intervertebral disc degeneration.	hsa_circ_0041946				human intervertebral disc degeneration / IDD	MONDO:0011385	intervertebral disk degenerative disorder	down-regulated	RT-qPCR; Microarray	"hsa_circ_0041946 was identified from circRNA expression profiling and experimentally validated by RT-qPCR as significantly downregulated in degenerative disc samples. The study suggests it may be potentially involved in IDD, but no specific molecular mechanism was determined."	0.4032
28990083	Molecular medicine reports	2017	Confirmation and preliminary analysis of circRNAs potentially involved in human intervertebral disc degeneration.	hsa_circ_0055412		hsa_circ_CAPG	CAPG	human intervertebral disc degeneration / IDD	MONDO:0011385	intervertebral disk degenerative disorder	up-regulated	Microarray	"hsa_circ_0055412 was identified as upregulated in IDD together with its host gene CAPG. The authors suggest this circRNA-host gene pair may be related to the Fas apoptosis pathway in IDD, although no direct functional validation was performed."	0.1768
28990083	Molecular medicine reports	2017	Confirmation and preliminary analysis of circRNAs potentially involved in human intervertebral disc degeneration.	hsa_circ_0004619		hsa_circ_FAF1	FAF1	human intervertebral disc degeneration / IDD	MONDO:0011385	intervertebral disk degenerative disorder	down-regulated	Microarray	"hsa_circ_0004619 was identified as downregulated in IDD while its host gene FAF1 was upregulated. The study links this circRNA-host gene pair to the Fas pathway, but the association was based on microarray and bioinformatic co-expression analysis rather than direct functional validation."	0.1768
28990083	Molecular medicine reports	2017	Confirmation and preliminary analysis of circRNAs potentially involved in human intervertebral disc degeneration.	hsa_circ_0007279		hsa_circ_NRG1	NRG1	human intervertebral disc degeneration / IDD	MONDO:0011385	intervertebral disk degenerative disorder	up-regulated	Microarray	"hsa_circ_0007279 was identified as upregulated in IDD while its host gene NRG1 was downregulated. Because NRG1 is described as part of the epidermal growth factor receptor pathway, the study suggests this circRNA-host gene pair may be relevant to growth factor-related processes in IDD."	0.1768
28990083	Molecular medicine reports	2017	Confirmation and preliminary analysis of circRNAs potentially involved in human intervertebral disc degeneration.	hsa_circ_0002075		hsa_circ_BMP1	BMP1	human intervertebral disc degeneration / IDD	MONDO:0011385	intervertebral disk degenerative disorder	up-regulated	Microarray	"hsa_circ_0002075 was identified as upregulated in IDD together with its host gene BMP1. The authors highlight BMP1 as a growth factor, suggesting that this circRNA-host gene pair may be relevant to growth factor-related mechanisms in IDD."	0.1768
29042195	Biochemical and biophysical research communications	2017	Circular RNA WDR77 target FGF-2 to regulate vascular smooth muscle cells proliferation and migration by sponging miR-124.	hsa_circ_0013509	circWDR77	hsa_circ_WDR77	WDR77	Diabetes mellitus / DM	MONDO:0005015	diabetes mellitus	up-regulated	RT-qPCR; Microarray	"circWDR77 (hsa_circ_0013509), derived from WDR77, is up-regulated in high glucose-induced human VSMCs. It promotes VSMC proliferation, cell cycle progression, and migration by sponging miR-124 and regulating FGF2 expression through the circWDR77-miR-124-FGF2 axis, suggesting relevance to diabetes mellitus-associated vascular disease."	0.7626
29045858	Clinica chimica acta; international journal of clinical chemistry	2018	Circulating circular RNA hsa_circ_0001785 acts as a diagnostic biomarker for breast cancer detection.	hsa_circ_0001785				breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001785 is up-regulated in plasma from breast cancer patients and was validated by RT-qPCR after microarray screening. It showed diagnostic value for breast cancer detection and was associated with histological grade, TNM stage and distant metastasis."	0.5662
29045858	Clinica chimica acta; international journal of clinical chemistry	2018	Circulating circular RNA hsa_circ_0001785 acts as a diagnostic biomarker for breast cancer detection.	hsa_circ_0108942				breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0108942 was identified by circRNA microarray as a candidate circulating circRNA and was validated by RT-qPCR as significantly increased in breast cancer plasma. ROC analysis suggested diagnostic potential, although lower than hsa_circ_0001785."	0.5662
29045858	Clinica chimica acta; international journal of clinical chemistry	2018	Circulating circular RNA hsa_circ_0001785 acts as a diagnostic biomarker for breast cancer detection.	hsa_circ_0068033				breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	hsa_circ_0068033 was identified by circRNA microarray as a candidate circulating circRNA and was validated by RT-qPCR as decreased in breast cancer plasma. ROC analysis indicated limited diagnostic potential compared with hsa_circ_0001785.	0.5662
29098316	"Journal of molecular medicine (Berlin, Germany)"	2018	Plasma circular RNA profiling of patients with gastric cancer and their droplet digital RT-PCR detection.	hsa_circ_0001017				gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0001017 is downregulated in gastric cancer tissues, gastric dysplasia tissues, and preoperative plasma. Its plasma level has diagnostic and prognostic value, with low expression indicating poorer overall survival and postoperative recovery indicating longer disease-free survival."	0.6954
29098316	"Journal of molecular medicine (Berlin, Germany)"	2018	Plasma circular RNA profiling of patients with gastric cancer and their droplet digital RT-PCR detection.	hsa_circ_0061276				gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0061276 is downregulated in gastric cancer tissues and preoperative plasma and was one of the top reduced plasma circRNAs in the microarray profile. Its plasma level has diagnostic and prognostic value, with low expression indicating poorer overall survival and postoperative recovery indicating longer disease-free survival."	0.6954
29103021	Cancer biomarkers : section A of Disease markers	2018	"Hsa_circ_0000520, a potential new circular RNA biomarker, is involved in gastric carcinoma."	hsa_circ_0000520				gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"This study identified hsa_circ_0000520 as significantly down-regulated in gastric cancer tissues, plasma, and gastric cancer cell lines. Lower hsa_circ_0000520 expression was associated with more advanced TNM stage and CEA positivity, suggesting potential diagnostic biomarker value and a possible inhibitory role in gastric cancer development. The proposed mechanism is a predicted circRNA-miRNA-mRNA regulatory network, but the molecular mechanism remains unvalidated experimentally."	0.5047
29114076	The Journal of neuroscience : the official journal of the Society for Neuroscience	2018	Circular RNA DLGAP4 Ameliorates Ischemic Stroke Outcomes by Targeting miR-143 to Regulate Endothelial-Mesenchymal Transition Associated with Blood-Brain Barrier Integrity.		circular RNA DLGAP4 / mm9_circ_015028	hsa_circ_DLGAP4	DLGAP4	ischemic stroke	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR; Northern Blot	"circDLGAP4 is down-regulated in plasma from AIS patients and in the tMCAO mouse stroke model. It functions as an endogenous miR-143 sponge to regulate HECTD1 expression, inhibit EndoMT, preserve BBB integrity, and reduce ischemic brain injury. The study proposes plasma circDLGAP4 as a biomarker for AIS and circDLGAP4 restoration as a therapeutic strategy."	0.7858
29114076	The Journal of neuroscience : the official journal of the Society for Neuroscience	2018	Circular RNA DLGAP4 Ameliorates Ischemic Stroke Outcomes by Targeting miR-143 to Regulate Endothelial-Mesenchymal Transition Associated with Blood-Brain Barrier Integrity.		circular RNA DLGAP4 / mm9_circ_015028	mmu_circ_DLGAP4	DLGAP4	ischemic stroke	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR; Northern Blot	"circDLGAP4 is down-regulated in plasma from AIS patients and in the tMCAO mouse stroke model. It functions as an endogenous miR-143 sponge to regulate HECTD1 expression, inhibit EndoMT, preserve BBB integrity, and reduce ischemic brain injury. The study proposes plasma circDLGAP4 as a biomarker for AIS and circDLGAP4 restoration as a therapeutic strategy."	0.7858
29117539	Biochemical and biophysical research communications	2018	Hsa_circ_0009910 promotes carcinogenesis by promoting the expression of miR-449a target IL6R in osteosarcoma.	hsa_circ_0009910	circRNA_0009910 / circ_0009910	hsa_circ_MFN2	MFN2	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"hsa_circ_0009910 is up-regulated in osteosarcoma cells and tissues. It promotes OS cell proliferation and cell cycle progression while suppressing apoptosis by sponging miR-449a, thereby increasing IL6R expression and activating JAK1/STAT3 signaling."	0.7164
29125888	Journal of cellular biochemistry	2018	Circular RNA hsa_circ_0003221 (circPTK2) promotes the proliferation and migration of bladder cancer cells.	hsa_circ_0003221	circPTK2	hsa_circ_PTK2	PTK2	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0003221 (circPTK2) is up-regulated in bladder cancer tissues, patient blood, migrated cancer cells, and metastatic lymph nodes. Functional overexpression and knockdown experiments indicate that circPTK2 promotes bladder cancer cell proliferation, migration, invasion, and metastasis, and it may serve as a biomarker or therapeutic target, although the specific molecular mechanism was not defined."	0.6278
29183005	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2017	Microarray Expression Profile of Circular RNAs in Plasma from Primary Biliary Cholangitis Patients.		hsa_circ_402458			primary biliary cholangitis / PBC	MONDO:0005388	primary biliary cholangitis	up-regulated	RT-qPCR; Microarray	hsa_circ_402458 is up-regulated in plasma from PBC patients and showed the best diagnostic performance among tested candidates. The study suggests it may participate in PBC pathogenesis through predicted interactions with hsa-miR-522-3p and hsa-miR-943.	0.5963
29183005	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2017	Microarray Expression Profile of Circular RNAs in Plasma from Primary Biliary Cholangitis Patients.		hsa_circ_406329			primary biliary cholangitis / PBC	MONDO:0005388	primary biliary cholangitis	up-regulated	RT-qPCR; Microarray	hsa_circ_406329 is up-regulated in plasma from PBC patients and was evaluated as a diagnostic candidate. Its ROC performance was weaker than hsa_circ_402458 and did not reach statistical significance in the reported ROC analysis.	0.5662
29183005	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2017	Microarray Expression Profile of Circular RNAs in Plasma from Primary Biliary Cholangitis Patients.		hsa_circ_407176			primary biliary cholangitis / PBC	MONDO:0005388	primary biliary cholangitis	down-regulated	RT-qPCR; Microarray	hsa_circ_407176 is down-regulated in plasma from PBC patients in the large qRT-PCR validation cohort. It was further evaluated by ROC analysis and showed potential diagnostic value for PBC.	0.5662
29183005	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2017	Microarray Expression Profile of Circular RNAs in Plasma from Primary Biliary Cholangitis Patients.		hsa_circ_082319			primary biliary cholangitis / PBC	MONDO:0005388	primary biliary cholangitis	down-regulated	RT-qPCR; Microarray	"hsa_circ_082319 is down-regulated in plasma from PBC patients according to qRT-PCR validation. The study did not define a specific mechanism, pathway, or diagnostic ROC value for this circRNA."	0.4773
29216394	Toxicological sciences : an official journal of the Society of Toxicology	2018	CircLRP6 Regulation of ZEB1 via miR-455 Is Involved in the Epithelial-Mesenchymal Transition During Arsenite-Induced Malignant Transformation of Human Keratinocytes.		circLRP6 / hsa_circRNA_101014	hsa_circ_LRP6	LRP6	arsenite-induced malignant transformation of human keratinocytes / arsenite-induced carcinogenesis / human skin cancers	MONDO:0002531	skin neoplasm	up-regulated	RT-qPCR	"circLRP6 is up-regulated during arsenite-induced malignant transformation of human HaCaT keratinocytes. It functions mainly in the cytoplasm as a miR-455 sponge, leading to increased ZEB1 expression and promotion of EMT, colony formation, migration, and invasion."	0.7909
29223555	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2017	Emerging roles of circular RNA hsa_circ_0000064 in the proliferation and metastasis of lung cancer.	hsa_circ_0000064	circ_0000064			lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"This study reports that hsa_circ_0000064 is up-regulated in lung cancer tissues and lung cancer cell lines. Functional knockdown experiments indicate that hsa_circ_0000064 supports proliferation, cell cycle progression, migration and invasion while suppressing apoptosis, with associated changes in apoptosis-, cell cycle- and invasion-related proteins. Clinically, its aberrant expression is correlated with T stage, lymphatic metastasis and TNM stage, suggesting potential biomarker and therapeutic-target value."	0.5828
29229385	Biochemical and biophysical research communications	2018	Circular RNA hsa_circ_0001564 regulates osteosarcoma proliferation and apoptosis by acting miRNA sponge.	hsa_circ_0001564	circ-CANX	hsa_circ_CANX	CANX	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001564 is up-regulated in osteosarcoma tissues and cell lines and functions as an oncogenic circRNA. Its knockdown suppresses proliferation and colony formation, induces G0/G1 cell cycle arrest, and promotes apoptosis, at least partly by sponging miR-29c-3p. The study suggests hsa_circ_0001564 may serve as a potential biomarker and therapeutic target for osteosarcoma."	0.7404
29240459	Biomarkers in medicine	2018	Downregulated expression of hsa_circ_0074362 in gastric cancer and its potential diagnostic values.	hsa_circ_0074362		hsa_circ_ARHGAP26	ARHGAP26	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"This study reports that hsa_circ_0074362 is significantly downregulated in gastric cancer tissues, gastric cancer cell lines, and gastritis tissues. Its expression is associated with CA19-9 and lymphatic metastasis, and ROC analysis suggests potential diagnostic biomarker value for gastric cancer screening, although the molecular mechanism was not experimentally defined."	0.6238
29247798	Gene	2018	Circular RNA expression profile of articular chondrocytes in an IL-1beta-induced mouse model of osteoarthritis.		mmu-circRNA-30365			osteoarthritis / OA	MONDO:0005178	osteoarthritis	dysregulated	RT-qPCR; RNA-seq	"mmu-circRNA-30365 was differentially expressed in IL-1beta-treated mouse articular chondrocytes, a cellular osteoarthritis model, and its expression change was verified by qRT-PCR. The study predicts that it may act as a miRNA sponge in a circRNA-miRNA-mRNA regulatory network and participate in OA pathogenesis."	0.4276
29247798	Gene	2018	Circular RNA expression profile of articular chondrocytes in an IL-1beta-induced mouse model of osteoarthritis.		mmu-circRNA-36866			osteoarthritis / OA	MONDO:0005178	osteoarthritis	dysregulated	RT-qPCR; RNA-seq	"mmu-circRNA-36866 was differentially expressed in IL-1beta-treated mouse articular chondrocytes, a cellular osteoarthritis model, and its expression change was verified by qRT-PCR. The study predicts that it may act as a miRNA sponge in a circRNA-miRNA-mRNA regulatory network and participate in OA pathogenesis."	0.4276
29260931	Autophagy	2018	Engagement of circular RNA HECW2 in the nonautophagic role of ATG5 implicated in the endothelial-mesenchymal transition.		"circHECW2 / circular HECT, C2 and WW domain containing E3 ubiquitin protein ligase"	hsa_circ_HECW2	HECW2	BBB damage	MONDO:0000001	disease	up-regulated	RT-qPCR	"circHECW2/circHecw2 is upregulated in Meth- or LPS-stimulated HBMECs and in the hippocampus of LPS-treated mice. It acts as an endogenous sponge for MIR30D, thereby increasing ATG5 and activating downstream NOTCH1 signaling to promote endothelial-mesenchymal transition and BBB/cerebrovascular damage. Knockdown of circHECW2 suppresses EndoMT in vitro and in vivo, suggesting potential therapeutic relevance for BBB integrity damage in drug abuse and neuroinflammatory contexts."	0.6683
29260931	Autophagy	2018	Engagement of circular RNA HECW2 in the nonautophagic role of ATG5 implicated in the endothelial-mesenchymal transition.		"circHECW2 / circular HECT, C2 and WW domain containing E3 ubiquitin protein ligase"	mmu_circ_Hecw2	HECW2	BBB damage	MONDO:0000001	disease	up-regulated	RT-qPCR	"circHECW2/circHecw2 is upregulated in Meth- or LPS-stimulated HBMECs and in the hippocampus of LPS-treated mice. It acts as an endogenous sponge for MIR30D, thereby increasing ATG5 and activating downstream NOTCH1 signaling to promote endothelial-mesenchymal transition and BBB/cerebrovascular damage. Knockdown of circHECW2 suppresses EndoMT in vitro and in vivo, suggesting potential therapeutic relevance for BBB integrity damage in drug abuse and neuroinflammatory contexts."	0.6683
29268657	RNA biology	2018	Identification and characterization of circular RNAs in the silkworm midgut following Bombyx mori cytoplasmic polyhedrosis virus infection.		circRNA-3112			Bombyx mori cytoplasmic polyhedrosis virus (BmCPV) infection	MONDO:0005108	viral infectious disease	up-regulated	RNA-seq	"circRNA-3112 was identified by CircSeq as one of the most strongly up-regulated circRNAs in BmCPV-infected silkworm midgut. Its closest related linear transcript was annotated as B. mori spectrin beta chain, non-erythrocytic 5."	0.3528
29268657	RNA biology	2018	Identification and characterization of circular RNAs in the silkworm midgut following Bombyx mori cytoplasmic polyhedrosis virus infection.		circRNA_4672			Bombyx mori cytoplasmic polyhedrosis virus (BmCPV) infection	MONDO:0005108	viral infectious disease	down-regulated	RNA-seq	circRNA_4672 was identified by CircSeq as the most down-regulated circRNA in BmCPV-infected silkworm midgut. Its closest related linear transcript was annotated as B. mori sodium-dependent nutrient amino acid transporter 1-like.	0.3528
29268657	RNA biology	2018	Identification and characterization of circular RNAs in the silkworm midgut following Bombyx mori cytoplasmic polyhedrosis virus infection.		circRNA-1193			Bombyx mori cytoplasmic polyhedrosis virus (BmCPV) infection	MONDO:0005108	viral infectious disease	up-regulated	RT-qPCR; RNA-seq	circRNA-1193/circRNA1193 was selected for RT-qPCR validation and showed induction after BmCPV infection in silkworm midgut. Its expression tendency was consistent with CircSeq data.	0.4358
29268657	RNA biology	2018	Identification and characterization of circular RNAs in the silkworm midgut following Bombyx mori cytoplasmic polyhedrosis virus infection.		circRNA2439			Bombyx mori cytoplasmic polyhedrosis virus (BmCPV) infection	MONDO:0005108	viral infectious disease	up-regulated	RT-qPCR; RNA-seq	circRNA2439 was selected for RT-qPCR validation and showed induced expression after BmCPV infection in silkworm midgut. Its expression tendency matched the CircSeq results.	0.4358
29268657	RNA biology	2018	Identification and characterization of circular RNAs in the silkworm midgut following Bombyx mori cytoplasmic polyhedrosis virus infection.		circRNA5655			Bombyx mori cytoplasmic polyhedrosis virus (BmCPV) infection	MONDO:0005108	viral infectious disease	up-regulated	RT-qPCR; RNA-seq	circRNA5655 was selected for RT-qPCR validation and showed induced expression after BmCPV infection in silkworm midgut. Its expression tendency matched the CircSeq results.	0.4358
29268657	RNA biology	2018	Identification and characterization of circular RNAs in the silkworm midgut following Bombyx mori cytoplasmic polyhedrosis virus infection.		circRNA6031			Bombyx mori cytoplasmic polyhedrosis virus (BmCPV) infection	MONDO:0005108	viral infectious disease	up-regulated	RT-qPCR; RNA-seq	circRNA6031 was selected for RT-qPCR validation and showed induced expression after BmCPV infection in silkworm midgut. Its expression tendency matched the CircSeq results.	0.4358
29268657	RNA biology	2018	Identification and characterization of circular RNAs in the silkworm midgut following Bombyx mori cytoplasmic polyhedrosis virus infection.		circRNA0962			Bombyx mori cytoplasmic polyhedrosis virus (BmCPV) infection	MONDO:0005108	viral infectious disease	up-regulated	RT-qPCR; RNA-seq	circRNA0962 was selected for RT-qPCR validation and showed induced expression after BmCPV infection in silkworm midgut. Its expression tendency matched the CircSeq results.	0.4358
29270748	Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban	2017	Overexpression of CircRNA BCRC4 regulates cell apoptosis and MicroRNA-101/EZH2 signaling in bladder cancer.		CircRNA BCRC4 / hsa_circ_001598	hsa_circ_RANBP9		bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"BCRC4 is down-regulated in bladder cancer tissues and bladder cancer cell lines. Its overexpression suppresses bladder cancer cell viability/proliferation and promotes apoptosis, at least partly through the miR-101/EZH2 regulatory axis. GA treatment up-regulates BCRC4 in bladder cancer cells, suggesting BCRC4 may contribute to anticancer effects and may be a therapeutic target."	0.6046
29305974	Gene	2018	"Circular RNA Atp9b, a competing endogenous RNA, regulates the progression of osteoarthritis by targeting miR-138-5p."		circRNA_Atp9b / circ_15898	mmu_circ_Atp9b	Atp9b	osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; RNA-seq	"circRNA_Atp9b is a mouse Atp9b-derived circRNA up-regulated in IL-1beta-induced chondrocytes, an in vitro osteoarthritis model. It promotes OA-related ECM degradation and inflammatory factor production by acting as a sponge for miR-138-5p; its knockdown increases type II collagen and decreases MMP13, COX-2 and IL-6."	0.6868
29333615	Journal of clinical laboratory analysis	2018	Circular RNA hsa_circ_0000567 can be used as a promising diagnostic biomarker for human colorectal cancer.	hsa_circ_0000567		hsa_circ_SETD3	SETD3	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"Hsa_circ_0000567 is a SETD3-derived circular RNA that is significantly downregulated in colorectal cancer tissues and cell lines. Its reduced expression is associated with larger tumors, metastasis, and advanced TNM stage, while knockdown promotes CRC cell proliferation and migration, supporting a tumor-suppressive role. ROC analysis suggests hsa_circ_0000567 has potential diagnostic biomarker value for CRC."	0.7729
29334253	Epigenomics	2018	Circular RNA expression in extracellular vesicles isolated from serum of patients with endometrial cancer.	hsa_circ_0109046				endometrial cancer	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR; RNA-seq	"hsa circ 0109046 was up-regulated in extracellular vesicles isolated from serum of patients with endometrial cancer and was validated by RT-qPCR. The study predicted circRNA/miRNA interactions, suggesting a possible EV-associated ceRNA role and potential biomarker relevance, but did not experimentally test downstream function."	0.585
29334253	Epigenomics	2018	Circular RNA expression in extracellular vesicles isolated from serum of patients with endometrial cancer.	hsa_circ_0002577				endometrial cancer	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR; RNA-seq	"hsa circ 0002577 was up-regulated in extracellular vesicles isolated from serum of patients with endometrial cancer and was validated by RT-qPCR. The study predicted circRNA/miRNA interactions, suggesting a possible EV-associated ceRNA role and potential biomarker relevance, but did not experimentally test downstream function."	0.585
29337055	Biochemical and biophysical research communications	2018	"A novel circular RNA, hsa_circ_0046701, promotes carcinogenesis by increasing the expression of miR-142-3p target ITGB8 in glioma."	hsa_circ_0046701				glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"hsa_circ_0046701 is up-regulated in glioma tissues and cell lines and acts as an oncogenic circRNA. It promotes glioma cell proliferation and invasion by sponging miR-142-3p and increasing expression of the miR-142-3p target ITGB8, suggesting potential therapeutic relevance."	0.7164
29337065	Biochemical and biophysical research communications	2018	"Downregulated circular RNA hsa_circ_0001649 regulates proliferation, migration and invasion in cholangiocarcinoma cells."	hsa_circ_0001649				Cholangiocarcinoma / CCA	MONDO:0019087	cholangiocarcinoma	down-regulated	RT-qPCR	"This study identifies hsa_circ_0001649 as a downregulated circRNA in cholangiocarcinoma tissues and cell lines. hsa_circ_0001649 acts as a tumor suppressor by inhibiting proliferation, migration, invasion and in vivo tumor growth while promoting apoptosis, with MMP-9 implicated in its effect on invasion. Clinically, reduced expression is associated with larger tumor size and poorer differentiation grade."	0.622
29343848	Oncogene	2018	A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis.	hsa_circ_0001649	circ-SHPRH / circular SHPRH	hsa_circ_SHPRH	SHPRH	glioblastoma / GBM	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR; Northern Blot; ISH; RNA-seq	"circ-SHPRH is a human SHPRH-derived circular RNA that is down-regulated in glioblastoma. It encodes the 17 kDa protein SHPRH-146aa, which suppresses glioblastoma cell proliferation and tumorigenicity by protecting full-length SHPRH from ubiquitin-proteasome degradation and promoting SHPRH-mediated PCNA ubiquitination. Higher expression of the encoded SHPRH-146aa is associated with longer survival in glioblastoma patients."	0.7886
29363043	Molecular neurobiology	2018	"Functional Characterization of Novel Circular RNA Molecule, circzip-2 and Its Synthesizing Gene zip-2 in C. elegans Model of Parkinson's Disease."		circzip-2 / cel_circ_000006	cel_circ_zip-2	zip-2	Parkinson's disease / PD	MONDO:0005180	Parkinson disease	down-regulated	RT-qPCR	"This study identified and validated circzip-2/cel_circ_000006 as a zip-2-derived circRNA in C. elegans and showed that it is significantly downregulated in a transgenic Parkinson's disease model. The authors propose that circzip-2 may sponge miR-60/miR-60-3p, and that loss of circzip-2 may increase miR-60 activity and suppress protective downstream genes. The linked zip-2/daf-16 pathway findings suggest a protective role for circzip-2/zip-2-related regulation in PD-associated phenotypes such as alpha-synuclein aggregation, oxidative stress, and lifespan."	0.5971
29366790	Biochemical and biophysical research communications	2018	Increased circular RNA hsa_circ_0012673 acts as a sponge of miR-22 to promote lung adenocarcinoma proliferation.	hsa_circ_0012673	circ_0012673	hsa_circ_DHCR24	DHCR24	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"hsa_circ_0012673 is up-regulated in lung adenocarcinoma tissues and cell lines, and its expression is associated with tumour size. It primarily localizes in the cytoplasm and promotes LAC proliferation through a ceRNA mechanism by sponging miR-22 and increasing ErbB3 protein expression; knockdown suppresses proliferation in vitro and tumour growth in a xenograft model."	0.8314
29372377	Journal of cancer research and clinical oncology	2018	Microarray profiles reveal that circular RNA hsa_circ_0007385 functions as an oncogene in non-small cell lung cancer tumorigenesis.	hsa_circ_0007385	circ_0007385			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0007385 is up-regulated in NSCLC tissues and cells and acts as an oncogenic circRNA. Its knockdown suppresses NSCLC cell proliferation, migration and invasion in vitro and reduces xenograft tumor growth in vivo. Mechanistically, the study suggests that hsa_circ_0007385 may function through a miR-181-related regulatory pathway."	0.7785
29378234	Journal of hepatology	2018	Circular RNA cSMARCA5 inhibits growth and metastasis in hepatocellular carcinoma.	hsa_circ_0001445	cSMARCA5	hsa_circ_SMARCA5	SMARCA5	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"cSMARCA5 (hsa_circ_0001445), derived from SMARCA5 exons 15 and 16, is significantly downregulated in HCC and its low expression predicts aggressive disease and poor survival after hepatectomy. Functionally, cSMARCA5 suppresses HCC cell growth, migration and metastasis in vitro and in xenograft models. Mechanistically, DHX9 upregulation contributes to cSMARCA5 downregulation, while cSMARCA5 sponges miR-17-3p and miR-181b-5p to upregulate the tumor suppressor TIMP3."	0.9057
29401612	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2018	Silica-induced initiation of circular ZC3H4 RNA/ZC3H4 pathway promotes the pulmonary macrophage activation.		circular ZC3H4 (circZC3H4) RNA / circRNA-0001544	mmu_circ_Zc3h4	Zc3h4	silicosis	MONDO:0005960	silicosis	up-regulated	RT-qPCR; ISH	"circZC3H4 RNA/circRNA-0001544 is up-regulated in SiO2-induced macrophage activation and derives from the Zc3h4 gene. It functions as a ceRNA for miR-212, thereby relieving miR-212-mediated repression of ZC3H4 protein and promoting macrophage activation. Through the circZC3H4 RNA/ZC3H4 pathway, SiO2-activated macrophages enhance pulmonary fibroblast proliferation and migration, contributing to silicosis-related pulmonary fibrosis."	0.6722
29414822	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	Expression Profiling Identifies Circular RNA Signature in Hepatoblastoma.	hsa_circ_0015756	circ_0015756			hepatoblastoma / HB	MONDO:0018666	hepatoblastoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0015756/circ_0015756 is up-regulated in hepatoblastoma tissues, peripheral blood, and malignant hepatoblastoma-related cell lines. Functional assays show that circ_0015756 supports hepatoblastoma cell viability, proliferation, and invasion, at least partly through a miR-1250-3p sponge mechanism. The authors propose it as a potential target for hepatoblastoma prognosis, diagnosis, and treatment."	0.7372
29414822	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	Expression Profiling Identifies Circular RNA Signature in Hepatoblastoma.	hsa_circ_0040081	circ_0040081			hepatoblastoma / HB	MONDO:0018666	hepatoblastoma	down-regulated	RT-qPCR; Microarray	"circ_0040081 is a down-regulated circRNA validated by qRT-PCR in peripheral blood from hepatoblastoma patients and in hepatoblastoma tissues compared with controls. The study did not experimentally define its molecular mechanism or biological function, but its altered expression supports the broader conclusion that circRNAs may be involved in hepatoblastoma pathogenesis."	0.3588
29421663	Biochemical and biophysical research communications	2018	Hsa_circ_0001649: A circular RNA and potential novel biomarker for colorectal cancer.	hsa_circ_0001649		hsa_circ_SHPRH	SHPRH	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"This study reports that hsa_circ_0001649 is down-regulated in colorectal cancer tissues, HCT116 cells, and patient serum. Its expression is negatively correlated with pathological differentiation and shows potential diagnostic value for CRC, but the molecular mechanism was not determined."	0.5958
29436673	Oncology reports	2018	Differentially expressed circRNAs in melanocytes and melanoma cells and their effect on cell proliferation and invasion.	hsa_circ_0000082	circRNA0000082			melanoma	MONDO:0005105	melanoma	up-regulated	RT-qPCR; Microarray	"circ0000082 is up-regulated in melanoma cell lines compared with human melanocytes. Its knockdown suppresses proliferation and invasion of high-metastatic WM451 cells, and bioinformatics predicts that it may act through a circRNA-miRNA-mRNA ceRNA network."	0.4852
29436673	Oncology reports	2018	Differentially expressed circRNAs in melanocytes and melanoma cells and their effect on cell proliferation and invasion.	hsa_circ_0016418	circRNA0016418			melanoma	MONDO:0005105	melanoma	up-regulated	RT-qPCR; Microarray	"circ0016418 is up-regulated in melanoma cell lines compared with human melanocytes. Silencing circ0016418 inhibits WM451 cell proliferation and invasion, suggesting a tumor-promoting role in melanoma."	0.4852
29436673	Oncology reports	2018	Differentially expressed circRNAs in melanocytes and melanoma cells and their effect on cell proliferation and invasion.	hsa_circ_0023988	circRNA0023988			melanoma	MONDO:0005105	melanoma	down-regulated	RT-qPCR; Microarray	"circ0023988 is down-regulated in melanoma cell lines. Its silencing increases WM35 cell proliferation and invasion, suggesting that circ0023988 normally suppresses these malignant phenotypes; predicted ceRNA analyses implicate miRNA-mRNA regulatory interactions."	0.4852
29436673	Oncology reports	2018	Differentially expressed circRNAs in melanocytes and melanoma cells and their effect on cell proliferation and invasion.	hsa_circ_0008157	circRNA0008157			melanoma	MONDO:0005105	melanoma	down-regulated	RT-qPCR; Microarray	"circ0008157 is down-regulated in melanoma cell lines. Knockdown of circ0008157 promotes proliferation and invasion of WM35 cells, indicating that it may have a suppressive role in melanoma malignant phenotypes."	0.4852
29436673	Oncology reports	2018	Differentially expressed circRNAs in melanocytes and melanoma cells and their effect on cell proliferation and invasion.	hsa_circ_0030388	circRNA0030388			melanoma	MONDO:0005105	melanoma	down-regulated	RT-qPCR; Microarray	"circ0030388 is down-regulated in melanoma cell lines. Its knockdown promotes proliferation and invasion in WM35 cells, suggesting an inhibitory role in melanoma progression; the study also predicted circ0030388-associated miRNA-mRNA interactions."	0.4852
29448254	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Active Tuberculosis Patients.		hsa_circRNA_001937			active tuberculosis	MONDO:0100481	active tuberculosis	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_001937 is up-regulated in PBMCs from active TB patients and was validated by qRT-PCR. It showed diagnostic value, correlated with radiological disease severity, decreased after anti-TB therapy, and was predicted to interact with several miRNAs."	0.6556
29448254	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Active Tuberculosis Patients.		hsa_circRNA_009024			active tuberculosis	MONDO:0100481	active tuberculosis	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_009024 is up-regulated in PBMCs from active TB patients and was validated by qRT-PCR. It showed diagnostic potential and, in combination with hsa_circRNA_001937, improved discrimination of active TB from healthy controls."	0.63
29448254	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Active Tuberculosis Patients.		hsa_circRNA_005086			active tuberculosis	MONDO:0100481	active tuberculosis	up-regulated	RT-qPCR; Microarray	hsa_circRNA_005086 is up-regulated in PBMCs from active TB patients and was validated by qRT-PCR. It showed diagnostic potential by ROC analysis but was not correlated with radiological severity scores.	0.63
29448254	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Active Tuberculosis Patients.		hsa_circRNA_102101			active tuberculosis	MONDO:0100481	active tuberculosis	down-regulated	RT-qPCR; Microarray	hsa_circRNA_102101 is down-regulated in PBMCs from active TB patients and was validated by qRT-PCR. It showed diagnostic potential and was correlated with radiological severity scores.	0.63
29448254	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Active Tuberculosis Patients.		hsa_circRNA_104964			active tuberculosis	MONDO:0100481	active tuberculosis	down-regulated	RT-qPCR; Microarray	hsa_circRNA_104964 is down-regulated in PBMCs from active TB patients and was validated by qRT-PCR. It showed diagnostic potential by ROC analysis but was not correlated with radiological severity scores.	0.63
29448254	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	Microarray Expression Profile of Circular RNAs in Peripheral Blood Mononuclear Cells from Active Tuberculosis Patients.		hsa_circRNA_104296			active tuberculosis	MONDO:0100481	active tuberculosis	down-regulated	RT-qPCR; Microarray	hsa_circRNA_104296 is down-regulated in PBMCs from active TB patients and was validated by qRT-PCR. It showed diagnostic potential by ROC analysis but was not correlated with radiological severity scores.	0.63
29454093	Cancer letters	2018	Silencing circular RNA hsa_circ_0000977 suppresses pancreatic ductal adenocarcinoma progression by stimulating miR-874-3p and inhibiting PLK1 expression.	hsa_circ_0000977	circ-0000977			pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000977 is up-regulated in pancreatic ductal adenocarcinoma and high expression predicts poorer overall survival. Functionally, it promotes PDAC proliferation, cell cycle progression, and tumor growth by sponging miR-874-3p and increasing PLK1 expression, making it a potential prognostic biomarker and therapeutic target."	0.8554
29458020	Biochemical and biophysical research communications	2018	CircRNA circ_0067934 promotes tumor growth and metastasis in hepatocellular carcinoma through regulation of miR-1324/FZD5/Wnt/beta-catenin axis.	hsa_circ_0067934	circ_0067934			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH	"circ_0067934 is up-regulated in HCC tissues and cell lines and its high expression is associated with advanced disease and poor prognosis. Functionally, circ_0067934 promotes proliferation, migration, invasion, tumor growth and metastasis while inhibiting apoptosis. Mechanistically, it suppresses miR-1324, thereby increasing FZD5 and activating the Wnt/beta-catenin pathway."	0.7373
29490568	"Reproductive sciences (Thousand Oaks, Calif.)"	2018	The Relationship of Circular RNAs With Ovarian Endometriosis.	hsa_circ_0004712	circ_0004712			ovarian endometriosis	MONDO:0006337	ovarian endometriosis	up-regulated	RT-qPCR; Microarray	"circ_0004712 is up-regulated in ovarian ectopic endometrium compared with paired eutopic endometrium and was validated by qRT-PCR. The study predicts that it may act as a miRNA sponge, including targeting miR-503, and may regulate endometriosis-related genes such as VDR, SCN3B, ENTPD1, and DGKG."	0.585
29490568	"Reproductive sciences (Thousand Oaks, Calif.)"	2018	The Relationship of Circular RNAs With Ovarian Endometriosis.	hsa_circ_0002198	circ_0002198			ovarian endometriosis	MONDO:0006337	ovarian endometriosis	up-regulated	RT-qPCR; Microarray	"circ_0002198 is up-regulated in ovarian ectopic endometrium and its differential expression was confirmed by qRT-PCR. The study predicts that circ_0002198 may act as a miRNA sponge, targeting miR-503 and regulating downstream genes such as SCN3B and ENTPD1 in ovarian endometriosis."	0.585
29490568	"Reproductive sciences (Thousand Oaks, Calif.)"	2018	The Relationship of Circular RNAs With Ovarian Endometriosis.	hsa_circ_0003570	circ_0003570			ovarian endometriosis	MONDO:0006337	ovarian endometriosis	down-regulated	RT-qPCR; Microarray	"circ_0003570 is down-regulated in ovarian ectopic endometrium and was confirmed by qRT-PCR. The study predicts that circ_0003570 may participate in an endometriosis-related circRNA-miRNA-mRNA network, with associated target genes including PPP1R9A and MBOAT1."	0.585
29490568	"Reproductive sciences (Thousand Oaks, Calif.)"	2018	The Relationship of Circular RNAs With Ovarian Endometriosis.	hsa_circ_0008951	circ_0008951			ovarian endometriosis	MONDO:0006337	ovarian endometriosis	up-regulated	RT-qPCR; Microarray	circ_0008951 is up-regulated in ovarian ectopic endometrium and was validated by qRT-PCR. The study predicts that it may act as a miRNA sponge targeting miR-29c and may regulate THRB-associated thyroid hormone signaling in ovarian endometriosis.	0.585
29490568	"Reproductive sciences (Thousand Oaks, Calif.)"	2018	The Relationship of Circular RNAs With Ovarian Endometriosis.	hsa_circ_0017248	circ_0017248			ovarian endometriosis	MONDO:0006337	ovarian endometriosis	up-regulated	RT-qPCR; Microarray	circ_0017248 is up-regulated in ovarian ectopic endometrium and its differential expression was confirmed by qRT-PCR. The study includes circ_0017248 among five circRNAs predicted to function as miRNA sponges in a circRNA-miRNA-mRNA network relevant to ovarian endometriosis.	0.585
29490945	Cancer research	2018	ERbeta-Mediated Alteration of circATP2B1 and miR-204-3p Signaling Promotes Invasion of Clear Cell Renal Cell Carcinoma.		circATP2B1 / circRNA 000826	hsa_circ_ATP2B1	ATP2B1	clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	unknown	RT-qPCR	"circATP2B1 is a suppressive circRNA in the ERbeta-driven ccRCC invasion pathway. ERbeta represses circATP2B1 through the ATP2B1 promoter, and reduced circATP2B1 decreases miR-204-3p stability, thereby increasing FN1 expression and promoting invasion and metastasis."	0.7754
29506122	Biology of reproduction	2018	Profiles of circular RNAs in human placenta and their potential roles related to preeclampsia.		hg38_circ_0014736			preeclampsia / PE	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR; RNA-seq	"hg38_circ_0014736 was significantly up-regulated in preeclamptic placentas and was one of three altered circRNAs further analyzed. Bioinformatics suggested that it may participate in preeclampsia pathogenesis through predicted circRNA-miRNA-mRNA/ceRNA interactions involving proliferation, hypoxia response, apoptosis, Wnt-signaling and HIF-1-related processes."	0.585
29506122	Biology of reproduction	2018	Profiles of circular RNAs in human placenta and their potential roles related to preeclampsia.	hsa_circ_0015382				preeclampsia / PE	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0015382 was significantly up-regulated in preeclamptic placentas and was one of three altered circRNAs further analyzed. Bioinformatics suggested that it may participate in preeclampsia pathogenesis through predicted circRNA-miRNA-mRNA/ceRNA interactions involving proliferation, hypoxia response, apoptosis, Wnt-signaling and HIF-1-related processes."	0.585
29506122	Biology of reproduction	2018	Profiles of circular RNAs in human placenta and their potential roles related to preeclampsia.	hsa_circ_0007121				preeclampsia / PE	MONDO:0005081	preeclampsia	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0007121 was significantly down-regulated in preeclamptic placentas and also reduced in plasma before 20 gestational weeks among women who later developed PE. It was proposed as a potential PE biomarker and may act through predicted circRNA-miRNA-mRNA/ceRNA networks linked to proliferation, hypoxia response, apoptosis, Wnt-signaling and HIF-1-related processes."	0.6556
29526758	Biochemical and biophysical research communications	2018	A potential risk factor of essential hypertension in case-control study: Circular RNA hsa_circ_0037911.	hsa_circ_0037911		hsa_circ_GSPT1	GSPT1	essential hypertension / EH	MONDO:0001134	essential hypertension	up-regulated	RT-qPCR; Microarray	"This case-control study found that hsa_circ_0037911 is significantly up-regulated in whole blood from essential hypertension patients and may increase EH risk. The circRNA showed diagnostic potential for EH and was positively correlated with serum creatinine. Mechanistically, the authors proposed that hsa_circ_0037911 may act as a miR-637 sponge and contribute to EH pathogenesis."	0.5963
29550475	Biochemical and biophysical research communications	2018	Circular RNA circMAN2B2 facilitates lung cancer cell proliferation and invasion via miR-1275/FOXK1 axis.		circMAN2B2 / hsa_circRNA_103595	hsa_circ_MAN2B2	MAN2B2	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; Microarray	"circMAN2B2 is up-regulated in lung cancer tissues and cell lines. It promotes lung cancer cell proliferation and invasion by acting as a miR-1275 sponge, thereby increasing FOXK1 expression. The study suggests circMAN2B2 may serve as a potential therapeutic target for lung cancer."	0.6777
29571246	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2018	Hsa_circ_0014717 is downregulated in colorectal cancer and inhibits tumor growth by promoting p16 expression.	hsa_circ_0014717	circ_0014717	hsa_circ_CCT3	CCT3	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"hsa_circ_0014717 is downregulated in colorectal cancer tissues and cell lines and lower expression is associated with advanced TNM stage, distal metastasis, and poorer overall survival. Functionally, hsa_circ_0014717 suppresses CRC proliferation, colony formation, cell cycle progression, and xenograft tumor growth. Mechanistically, it inhibits CRC growth at least partly by upregulating the tumor suppressor p16."	0.6584
29573483	Journal of the European Academy of Dermatology and Venereology : JEADV	2018	Circular RNA expression profile analysis of severe acne by RNA-Seq and bioinformatics.		circRNA_0084927			acne	MONDO:0011438	acne	down-regulated	RT-qPCR; RNA-seq	"circRNA_0084927 was significantly downregulated in severe acne lesional skin compared with paired adjacent non-lesional skin. The study validated its circular junction and differential expression, and proposed that it may contribute to severe acne through predicted circRNA-miRNA-mRNA regulatory networks."	0.5841
29573483	Journal of the European Academy of Dermatology and Venereology : JEADV	2018	Circular RNA expression profile analysis of severe acne by RNA-Seq and bioinformatics.		circRNA_0001073			acne	MONDO:0011438	acne	down-regulated	RT-qPCR; RNA-seq	"circRNA_0001073 was confirmed by PCR, Sanger sequencing, and qRT-PCR to be significantly downregulated in severe acne lesional skin. The authors suggest that the validated downregulated circRNAs may contribute to severe acne initiation and progression through predicted circRNA-miRNA-mRNA networks."	0.5841
29573483	Journal of the European Academy of Dermatology and Venereology : JEADV	2018	Circular RNA expression profile analysis of severe acne by RNA-Seq and bioinformatics.		circRNA_0005941			acne	MONDO:0011438	acne	down-regulated	RT-qPCR; RNA-seq	"circRNA_0005941 was significantly downregulated in severe acne lesions and validated by PCR, Sanger sequencing, and qRT-PCR. It was included in the predicted circRNA-miRNA-mRNA network, with miR-145-5p predicted as a target miRNA."	0.5841
29573483	Journal of the European Academy of Dermatology and Venereology : JEADV	2018	Circular RNA expression profile analysis of severe acne by RNA-Seq and bioinformatics.		circRNA_0086376			acne	MONDO:0011438	acne	down-regulated	RT-qPCR; RNA-seq	"circRNA_0086376 was validated as significantly downregulated in severe acne lesional skin. It was predicted to target miR-145-5p within a circRNA-miRNA-mRNA regulatory network, suggesting a possible contribution to acne pathogenesis."	0.5841
29573483	Journal of the European Academy of Dermatology and Venereology : JEADV	2018	Circular RNA expression profile analysis of severe acne by RNA-Seq and bioinformatics.		circRNA_0018168			acne	MONDO:0011438	acne	down-regulated	RT-qPCR; RNA-seq	"circRNA_0018168 was validated as significantly downregulated in severe acne lesional skin compared with adjacent non-lesional skin. It was predicted to target miR-145-5p and participate in circRNA-miRNA-mRNA regulation, potentially contributing to severe acne development."	0.5841
29588350	Cancer research	2018	The Circular RNA circPRKCI Promotes Tumor Growth in Lung Adenocarcinoma.	hsa_circ_0067934	circPRKCI	hsa_circ_PRKCI	PRKCI	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circPRKCI is a PRKCI-derived circular RNA from the 3q26.2 amplicon that is up-regulated in lung adenocarcinoma. It promotes LAC cell proliferation, invasion/migration and tumor growth by sponging miR-545 and miR-589 to increase E2F7 and regulate downstream p21/Cyclin D1 signaling. High circPRKCI expression is associated with larger tumors, advanced TNM stage and poor overall survival, and targeting circPRKCI suppresses xenograft growth and enhances gefitinib inhibition in EGFR-mutant cells."	0.8855
29602132	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2018	Increased expression of circRNA_102231 in lung cancer and its clinical significance.		circRNA_102231			lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; Microarray	"circRNA_102231 is up-regulated in lung adenocarcinoma tissues and is associated with advanced TNM stage, lymph node metastasis and poor overall survival. Functional knockdown experiments indicate that circRNA_102231 promotes lung cancer cell proliferation, migration and invasion in vitro. The study supports circRNA_102231 as a potential diagnostic, prognostic and therapeutic biomarker, although its detailed molecular mechanism was not defined."	0.7207
29605301	Biochemical and biophysical research communications	2018	Hsa_circ_0007534/miR-761/ZIC5 regulatory loop modulates the proliferation and migration of glioma cells.	hsa_circ_0007534				glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"hsa_circ_0007534 is up-regulated in glioma tissues and glioma cell lines and correlates with advanced tumor grade. It promotes glioma cell proliferation and migration by sponging miR-761, thereby increasing ZIC5 expression, suggesting the hsa_circ_0007534/miR-761/ZIC5 loop as a potential therapeutic target."	0.6479
29608893	Biochemical and biophysical research communications	2018	Circular RNA circC3P1 suppresses hepatocellular carcinoma growth and metastasis through miR-4641/PCK1 pathway.		circC3P1	hsa_circ_C3P1	C3P1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; ISH; RNA-seq	"circC3P1 is a human C3P1-derived circRNA that is down-regulated in HCC tissues and cell lines. In this study, circC3P1 functions as a tumor suppressor by inhibiting HCC proliferation, migration, invasion, tumor growth and lung metastasis, at least partly through the circC3P1/miR-4641/PCK1 ceRNA axis. Clinically, circC3P1 expression correlates with TNM stage, tumor size, vascular invasion and survival, suggesting potential prognostic biomarker value."	0.8057
29609527	Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine	2018	The differentially expressed circular ribonucleic acids of primary hepatic carcinoma following liver transplantation as new diagnostic biomarkers for primary hepatic carcinoma.		hsa_circ_102032			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circ_102032 was significantly up-regulated in pre-transplantation peripheral blood from PHC patients compared with normal controls and decreased after liver transplantation. The study suggests it may be associated with PHC and may have potential diagnostic biomarker value.	0.4773
29609527	Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine	2018	The differentially expressed circular ribonucleic acids of primary hepatic carcinoma following liver transplantation as new diagnostic biomarkers for primary hepatic carcinoma.		hsa_circ_103096			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circ_103096 was significantly up-regulated in pre-transplantation peripheral blood from PHC patients compared with normal controls and decreased after liver transplantation. The study suggests it may be associated with PHC and may have potential diagnostic biomarker value.	0.4773
29609527	Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine	2018	The differentially expressed circular ribonucleic acids of primary hepatic carcinoma following liver transplantation as new diagnostic biomarkers for primary hepatic carcinoma.		hsa_circ_102347			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_102347 was significantly up-regulated in pre-transplantation peripheral blood from PHC patients compared with normal controls and decreased after liver transplantation to a level similar to normal controls by postoperative day 7. The study identifies it as the circRNA most likely associated with PHC, potentially acting through a miR-203-related adsorption/sponging mechanism and serving as a diagnostic biomarker."	0.5135
29627570	Biochemical and biophysical research communications	2018	Circular RNA hsa_circ_0000673 promotes hepatocellular carcinoma malignance by decreasing miR-767-3p targeting SET.	hsa_circ_0000673				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH	"hsa_circ_0000673 is up-regulated in HCC tissues and high expression is associated with poor overall survival. It promotes HCC cell proliferation, invasion, and xenograft tumor growth by sponging miR-767-3p and regulating the downstream effector SET through a circRNA-miRNA-mRNA axis."	0.7357
29630526	Cancer biomarkers : section A of Disease markers	2018	Down-regulation of hsa_circ_0001649 in hepatocellular carcinoma predicts a poor prognosis.	hsa_circ_0001649	hsa_circ_001599			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"In this study, hsa_circ_0001649 was significantly down-regulated in HCC tissues and several HCC cell lines. Low expression predicted poorer overall survival, while high expression was favorable. Functional assays showed that hsa_circ_0001649 over-expression suppresses HCC cell proliferation, migration and invasion and promotes apoptosis, suggesting a tumor-suppressive role and potential prognostic/therapeutic value."	0.6527
29635069	Cancer letters	2018	Circular RNA ciRS-7 accelerates ESCC progression through acting as a miR-876-5p sponge to enhance MAGE-A family expression.		ciRS-7 / CDR1as	hsa_circ_CDR1	CDR1	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"ciRS-7 is up-regulated in ESCC tissues and is associated with poorer clinicopathological features. It promotes ESCC cell proliferation, migration, invasion, tumor growth and metastasis by sponging miR-876-5p and relieving repression of MAGE-A family genes, indicating an oncogenic role and potential therapeutic relevance in ESCC."	0.8438
29658568	International journal of oncology	2018	"Circular RNA circCDK13 suppresses cell proliferation, migration and invasion by modulating the JAK/STAT and PI3K/AKT pathways in liver cancer."	hsa_circ_0001699	circCDK13	hsa_circ_CDK13	CDK13	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"circCDK13 (hsa_circ_0001699), derived from the human CDK13 gene, is down-regulated in liver cancer cell lines and hepatocellular carcinoma tissues. Functional overexpression experiments show that circCDK13 suppresses liver cancer cell proliferation, migration, invasion, cell cycle progression, and xenograft tumor growth. Mechanistically, its tumor-suppressive effects are associated with inhibition of JAK/STAT and PI3K/AKT signaling, including decreased phosphorylated STAT3 and AKT."	0.7283
29678578	Biochemical and biophysical research communications	2018	Circular RNA circNASP modulates the malignant behaviors in osteosarcoma via miR-1253/FOXF1 pathway.	hsa_circ_0092340	circNASP	hsa_circ_NASP	NASP	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"circNASP (hsa_circ_0092340), derived from NASP, is up-regulated in osteosarcoma tissues and cell lines. It promotes osteosarcoma cell proliferation, cell cycle progression and invasion by sponging miR-1253 and thereby increasing FOXF1 expression. Clinically, higher circNASP expression correlates with larger tumor size and metastasis, suggesting therapeutic relevance."	0.6815
29679573	Biochemical and biophysical research communications	2018	circRNA expression analysis in lung adenocarcinoma: comparison of paired fresh frozen and formalin-fixed paraffin-embedded specimens.		hsa_circRNA_100421			lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_100421 was up-regulated in lung adenocarcinoma tissues and its expression change was confirmed by qRT-PCR. The study predicted that it may participate in a circRNA-miRNA-mRNA regulatory network, including predicted interactions with hsa-miR-145-5p, hsa-miR-520f-3p, hsa-miR-1178-3p and hsa-miR-876-3p."	0.5135
29679573	Biochemical and biophysical research communications	2018	circRNA expression analysis in lung adenocarcinoma: comparison of paired fresh frozen and formalin-fixed paraffin-embedded specimens.		hsa_circRNA_104329			lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_104329 was up-regulated in lung adenocarcinoma tissues and its expression pattern was confirmed by qRT-PCR. The study also constructed a predicted circRNA-miRNA-mRNA regulatory network for this circRNA, supporting its role as a potential lung adenocarcinoma-related circRNA candidate."	0.5135
29679573	Biochemical and biophysical research communications	2018	circRNA expression analysis in lung adenocarcinoma: comparison of paired fresh frozen and formalin-fixed paraffin-embedded specimens.		hsa_circRNA_101969			lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_101969 was down-regulated in lung adenocarcinoma tissues and its expression pattern was confirmed by qRT-PCR. The study also constructed a predicted circRNA-miRNA-mRNA regulatory network for this circRNA, supporting its role as a potential lung adenocarcinoma-related circRNA candidate."	0.5135
29687495	Journal of clinical laboratory analysis	2018	"Circular RNA hsa_circ_0008344 regulates glioblastoma cell proliferation, migration, invasion, and apoptosis."	hsa_circ_0008344	hsa_circRNA_0008344			glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0008344 is significantly up-regulated in IDH1 wild-type glioblastoma tissues. Functional knockdown experiments in U87 and U251 cells indicate that it promotes proliferation, colony formation, migration and invasion while suppressing apoptosis. The authors propose that hsa_circ_0008344 may contribute to glioblastoma progression and could be explored as a therapeutic target, with a putative miRNA-sponge mechanism suggested by bioinformatic prediction."	0.6093
29689350	Gene	2018	Hsa_circ_0079530 promotes cell proliferation and invasion in non-small cell lung cancer.	hsa_circ_0079530		hsa_circ_Twist1	Twist1	Non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0079530 is up-regulated in NSCLC tissues and cell lines and is associated with tumor size and lymph node metastasis. Functional knockdown experiments indicate that it acts as an oncogenic circRNA by promoting proliferation, cell cycle progression, migration, invasion and EMT-related changes, while ROC analysis suggests potential diagnostic biomarker value."	0.713
29693417	Epigenomics	2018	Circular RNA PVT1 expression and its roles in acute lymphoblastic leukemia.		circular RNA PVT1 / circPVT1	hsa_circ_PVT1	PVT1	acute lymphoblastic leukemia / ALL	MONDO:0004967	acute lymphoblastic leukemia	up-regulated	RT-qPCR	"circPVT1 is upregulated in acute lymphoblastic leukemia bone marrow samples and ALL cell lines. Functional knockdown experiments show that circPVT1 promotes ALL cell proliferation and suppresses apoptosis, at least partly through maintaining c-Myc and Bcl-2 protein expression. The study suggests circPVT1 has an oncogenic role and may represent a therapeutic target in ALL."	0.7126
29694981	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	CircRNA-Cdr1as Exerts Anti-Oncogenic Functions in Bladder Cancer by Sponging MicroRNA-135a.		CircRNA-Cdr1as / Cdr1as			bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR	"Cdr1as is significantly down-regulated in bladder cancer tissues and acts as a tumour suppressor. Its overexpression inhibits bladder cancer cell proliferation, migration, invasion, cell cycle entry, and xenograft tumour growth. Mechanistically, Cdr1as sponges miR-135a and partly restores p21 expression."	0.742
29698681	Biochemical and biophysical research communications	2018	Circular RNA hsa_circRNA_103809 promotes lung cancer progression via facilitating ZNF121-dependent MYC expression by sequestering miR-4302.		hsa_circRNA_103809	hsa_circ_ZFR	ZFR	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_103809 is up-regulated in lung cancer tissues and cell lines and high expression is associated with poorer survival. Functionally, it promotes lung cancer cell proliferation, colony formation, invasion, and xenograft tumor growth. Mechanistically, it sponges miR-4302 to increase ZNF121 expression, which elevates MYC protein levels and drives lung cancer progression."	0.7548
29700819	Immunology	2018	Circular RNA expression profile and potential function of hsa_circ_0045272 in systemic lupus erythematosus.	hsa_circ_0045272	hsa_circRNA_102165	hsa_circ_ERN1	ERN1	systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	down-regulated	RT-qPCR; Microarray	"hsa_circ_0045272 is significantly downregulated in T cells from SLE patients and was validated by qRT-PCR. Functional knockdown experiments in Jurkat cells showed that hsa_circ_0045272 negatively regulates early apoptosis and IL-2 secretion. Mechanistically, it can bind hsa-miR-6127 and may regulate putative ceRNA mRNAs such as NM_003466 (PAX8) and NM_015177 (DTX4), although the downstream miRNA-mRNA axis remains incompletely resolved."	0.7372
29702064	Archives of biochemistry and biophysics	2018	Circular RNA circMYO9B facilitates breast cancer cell proliferation and invasiveness via upregulating FOXP4 expression by sponging miR-4316.	hsa_circ_0000907	circMYO9B	hsa_circ_MYO9B	MYO9B	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circMYO9B is up-regulated in breast cancer tissues and cell lines and high expression is associated with poor survival and adverse clinicopathologic features. Functionally, circMYO9B promotes breast cancer cell proliferation, migration, invasion and xenograft tumor growth. Mechanistically, it acts through the circMYO9B/miR-4316/FOXP4 ceRNA axis by sponging miR-4316 to increase FOXP4 expression."	0.7789
29704631	Gene	2018	CircRNF13 regulates the invasion and metastasis in lung adenocarcinoma by targeting miR-93-5p.	hsa_circ_0001346	circRNF13	hsa_circ_RNF13	RNF13	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; ISH	"circRNF13 (hsa_circ_0001346), derived from RNF13, is down-regulated in lung adenocarcinoma tissues and is associated with TNM stage and lymph node metastasis. It mainly localizes in the cytoplasm and suppresses LAC cell migration, invasion and metastasis, at least partly by acting as an Ago2-associated sponge for miR-93-5p. The study proposes circRNF13 as a potential biomarker and therapeutic target for lung adenocarcinoma."	0.7974
29705695	Biochemical and biophysical research communications	2018	Circular RNA expression profiles in hippocampus from mice with perinatal glyphosate exposure.		mmu-circRNA-014015			glyphosate-induced neurotoxicity	MONDO:0005527	toxic encephalopathy	up-regulated	RT-qPCR; Microarray	"mmu-circRNA-014015 was up-regulated in the hippocampus of mouse offspring after perinatal glyphosate exposure and was validated by qRT-PCR. The study suggests it may participate in glyphosate-induced neurotoxicity, potentially through ceRNA-related regulation and stress-associated steroid metabolism pathways."	0.4851
29705695	Biochemical and biophysical research communications	2018	Circular RNA expression profiles in hippocampus from mice with perinatal glyphosate exposure.		mmu-circRNA-28128			glyphosate-induced neurotoxicity	MONDO:0005527	toxic encephalopathy	up-regulated	RT-qPCR; Microarray	"mmu-circRNA-28128 was up-regulated in the hippocampus of mouse offspring after perinatal glyphosate exposure and was validated by qRT-PCR. The study suggests it may participate in glyphosate-induced neurotoxicity, potentially through ceRNA-related regulation and stress-associated steroid metabolism pathways."	0.4851
29705695	Biochemical and biophysical research communications	2018	Circular RNA expression profiles in hippocampus from mice with perinatal glyphosate exposure.		mmu-circRNA-29837			glyphosate-induced neurotoxicity	MONDO:0005527	toxic encephalopathy	down-regulated	RT-qPCR; Microarray	"mmu-circRNA-29837 was down-regulated in the hippocampus of mouse offspring after perinatal glyphosate exposure and was validated by qRT-PCR. The authors hypothesized that it may act as a miRNA sponge in a circRNA-miRNA gene network, with predicted interactions including mmu-miR-7035e5p, mmu-miR-3083e5p, and mmu-miR-34a-5p, and may participate in glyphosate-induced neurotoxicity."	0.4851
29709702	Cancer letters	2018	Tumor-released exosomal circular RNA PDE8A promotes invasive growth via the miR-338/MACC1/MET pathway in pancreatic cancer.	hsa_circ_0036627	circ-PDE8A	hsa_circ_PDE8A	PDE8A	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circ-PDE8A is an up-regulated exosomal circRNA in PDAC that promotes invasive growth, proliferation, EMT, invasion and metastasis. Mechanistically, it functions as a miR-338 sponge to upregulate MACC1 and activate MET/AKT and ERK signaling. High tissue and plasma exosomal circ-PDE8A levels correlate with tumor progression and poor survival, suggesting biomarker potential."	0.8912
29710484	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2018	Emerging roles of hsa_circ_0005075 targeting miR-431 in the progress of HCC.	hsa_circ_0005075	circ_0005075	hsa_circ_EIF4G3	EIF4G3	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"hsa_circ_0005075 is up-regulated in HCC tissues and HCC cell lines. Functionally, it promotes SMMC-7721 cell proliferation, migration and invasion while suppressing apoptosis. Mechanistically, the study supports that hsa_circ_0005075 acts as a miR-431 sponge/ceRNA, and miR-431 inhibition rescues the effects of hsa_circ_0005075 knockdown."	0.7181
29710537	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2018	Hsa_circ_0071589 promotes carcinogenesis via the miR-600/EZH2 axis in colorectal cancer.	hsa_circ_0071589		hsa_circ_FAT1	FAT1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0071589 is up-regulated in colorectal cancer tissues and its high expression is associated with advanced clinical features and shorter overall survival. Functionally, it promotes CRC cell viability, proliferation, invasion and migration. Mechanistically, it acts as a miR-600 sponge to increase EZH2 expression, forming a hsa_circ_0071589/miR-600/EZH2 oncogenic regulatory axis."	0.817
29726904	Carcinogenesis	2018	"RNA-binding protein trinucleotide repeat-containing 6A regulates the formation of circular RNA circ0006916, with important functions in lung cancer cells."		circ0006916	hsa_circ_HOMER1	HOMER1	lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	"Circ0006916 is a HOMER1-derived human circRNA that is down-regulated in anti-BPDE-transformed bronchial epithelial cells, lung cancer cell lines, and many lung cancer tissues. It suppresses lung cancer cell proliferation by affecting G1/S cell cycle progression, acts as a miR-522-3p sponge that regulates PHLPP1, and its biogenesis is promoted by the RBP TNRC6A binding to flanking intronic regions."	0.8058
29738762	Biochemical and biophysical research communications	2018	Circular RNA hsa_circ_0023404 exerts an oncogenic role in cervical cancer through regulating miR-136/TFCP2/YAP pathway.	hsa_circ_0023404	circRNA_100876			Cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"hsa_circ_0023404 is up-regulated in cervical cancer tissues and cell lines, and high expression predicts poor prognosis. Functionally, it promotes cervical cancer cell proliferation, cell-cycle progression, migration and invasion. Mechanistically, it acts as a miR-136 sponge to increase TFCP2 expression and activate YAP signaling."	0.7113
29758559	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	"CircRNA-0004904, CircRNA-0001855, and PAPP-A: Potential Novel Biomarkers for the Prediction of Preeclampsia."	hsa_circ_0001855	circRNA_0001855			preeclampsia / PE	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR; Microarray	hsa_circ_0001855 was significantly up-regulated in peripheral blood cells from women who later developed PE before 20 weeks of gestation. The study predicts that it may function as a miRNA sponge to regulate PAPP-A expression and may contribute to an early PE diagnostic model together with hsa_circ_0004904 and PAPP-A.	0.6616
29758559	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	"CircRNA-0004904, CircRNA-0001855, and PAPP-A: Potential Novel Biomarkers for the Prediction of Preeclampsia."	hsa_circ_0004904	circRNA_0004904 			preeclampsia / PE	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR; Microarray	hsa_circ_0004904 was significantly up-regulated in peripheral blood cells from women who later developed PE before 20 weeks of gestation. The study predicts that it may function as a miRNA sponge to regulate PAPP-A expression and may contribute to an early PE diagnostic model together with hsa_circ_0001855 and PAPP-A.	0.6616
29777697	Biochemical and biophysical research communications	2018	circRNA_0084043 promote malignant melanoma progression via miR-153-3p/Snail axis.		circRNA_0084043	hsa_circ_ADAM9	ADAM9	melanoma	MONDO:0005105	melanoma	up-regulated	RT-qPCR; Microarray	"circRNA_0084043 is up-regulated in malignant melanoma tissues and melanoma cell lines, and high expression is associated with poorer overall survival. Functionally, it promotes melanoma proliferation, migration, invasion, metastasis and xenograft tumor growth. Mechanistically, circRNA_0084043 acts as a sponge for miR-153-3p to release and up-regulate Snail expression, supporting an oncogenic circRNA_0084043/miR-153-3p/Snail axis."	0.8424
29785842	Journal of clinical laboratory analysis	2018	Circular RNA 0068669 as a new biomarker for hepatocellular carcinoma metastasis.	hsa_circ_0068669	hsa_circ_103561	hsa_circ_SENP5	SENP5	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"This study identifies hsa_circ_0068669, a SENP5-derived human circRNA, as significantly downregulated in HCC tissues and HCC cell lines. Its low expression is associated with metastasis-related clinicopathological features including microvascular invasion and TNM stage, supporting its potential value as a biomarker for HCC metastasis rather than establishing a mechanistic regulatory axis."	0.5662
29790216	Journal of clinical laboratory analysis	2018	Decreased expression of hsa_circ_0137287 predicts aggressive clinicopathologic characteristics in papillary thyroid carcinoma.	hsa_circ_0137287		hsa_circ_SLC26A7	SLC26A7	papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0137287 is significantly downregulated in papillary thyroid carcinoma tissues compared with adjacent noncancerous thyroid tissues. Lower expression is associated with aggressive clinicopathologic features, including extrathyroidal extension, lymph node metastasis, advanced T stage and larger tumor size, and ROC analyses indicate potential diagnostic value for PTC and aggressive features."	0.5261
29803789	Cancer letters	2018	CircIRAK3 sponges miR-3607 to facilitate breast cancer metastasis.		circIRAK3 / circRNA_0005505	hsa_circ_IRAK3	IRAK3	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq; Microarray	"circIRAK3 is an oncogenic circRNA upregulated in metastatic breast cancer and associated with recurrence and poor recurrence-free survival. It promotes migration, invasion and lung metastasis by sponging miR-3607, thereby relieving repression of FOXC1 and establishing a positive-feedback loop with IRAK3 transcription."	0.8738
29805677	Oncology letters	2018	Tudor-staphylococcal nuclease regulates the expression and biological function of alkylglycerone phosphate synthase via nuclear factor-kappaB and microRNA-127 in human glioma U87MG cells.		circ-ubiquitin-associated protein 2 / circUBAP2	hsa_circ_UBAP2	UBAP2	glioma	MONDO:0021042	glioma	unknown	RT-qPCR	"In this glioma cell study, circUBAP2 was measured as a circular RNA whose expression was significantly reduced after AGPS silencing in U87MG cells. The paper did not directly test circUBAP2 function, subcellular localization, interacting partners, or clinical significance."	0.2586
29805677	Oncology letters	2018	Tudor-staphylococcal nuclease regulates the expression and biological function of alkylglycerone phosphate synthase via nuclear factor-kappaB and microRNA-127 in human glioma U87MG cells.		circ-zinc finger protein 292 / circZNF292	hsa_circ_ZNF292	ZNF292	glioma	MONDO:0021042	glioma	unknown	RT-qPCR	"In this glioma cell study, circZNF292 was measured as a circular RNA whose expression was significantly reduced after AGPS silencing in U87MG cells. The paper did not directly test circZNF292 function, subcellular localization, interacting partners, or clinical significance."	0.2586
29805677	Oncology letters	2018	Tudor-staphylococcal nuclease regulates the expression and biological function of alkylglycerone phosphate synthase via nuclear factor-kappaB and microRNA-127 in human glioma U87MG cells.		circ-homeodomain-interacting protein kinase 3 / circHIPK3	hsa_circ_HIPK3	HIPK3	glioma	MONDO:0021042	glioma	unknown	RT-qPCR	"In this glioma cell study, circHIPK3 was measured as a circular RNA whose expression was significantly reduced after AGPS silencing in U87MG cells. The paper did not directly test circHIPK3 function, subcellular localization, interacting partners, or clinical significance."	0.2586
29807010	Biochemical and biophysical research communications	2018	Circular RNA hsa_circ_0008039 promotes breast cancer cell proliferation and migration by regulating miR-432-5p/E2F3 axis.	hsa_circ_0008039		hsa_circ_PRKAR1B	PRKAR1B	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0008039 is up-regulated in breast cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation, cell-cycle progression, migration, and in vivo tumor growth by acting as a ceRNA for miR-432-5p and enhancing E2F3 expression. The study suggests the hsa_circ_0008039/miR-432-5p/E2F3 axis as a potential therapeutic target for breast cancer."	0.697
29842886	Biochemical and biophysical research communications	2018	Circular RNA circZFR contributes to papillary thyroid cancer cell proliferation and invasion by sponging miR-1261 and facilitating C8orf4 expression.	hsa_circ_0072088	circZFR	hsa_circ_ZFR	ZFR	papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"circZFR is an upregulated oncogenic circRNA in papillary thyroid cancer. It promotes PTC cell proliferation, migration and invasion by sponging miR-1261 and increasing C8orf4 expression, and its high expression is associated with advanced clinical features and worse prognosis."	0.7113
29844124	Cancer research	2018	Twist1 Regulates Vimentin through Cul2 Circular RNA to Promote EMT in Hepatocellular Carcinoma.		circ-10720 / Cul2 circular RNA	hsa_circ_Cul2	Cul2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH	"circ-10720 is a Cul2-derived circular RNA up-regulated in aggressive HCC and positively associated with Twist1, Vimentin, metastasis, advanced stage, and poor survival. Twist1 promotes circ-10720 formation, and circ-10720 acts as a miRNA sponge for Vimentin-targeting miRNAs, thereby increasing Vimentin expression, promoting EMT, proliferation, migration, invasion, tumor growth and metastasis. Its high expression may serve as a prognostic biomarker and therapeutic target in HCC."	0.807
29847813	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	The Landscape of Circular RNA Expression Profiles in Papillary Thyroid Carcinoma Based on RNA Sequencing.		chr5:160757890-160763776-			papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; RNA-seq	chr5:160757890-160763776- was up-regulated in PTC tissues and validated by qRT-PCR. It was evaluated as a potential diagnostic biomarker and was predicted to participate in a circRNA-miRNA-mRNA ceRNA network.	0.5963
29847813	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	The Landscape of Circular RNA Expression Profiles in Papillary Thyroid Carcinoma Based on RNA Sequencing.		chr12:40696591-40697936+			papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; RNA-seq	chr12:40696591-40697936+ was up-regulated in PTC tissues and validated by qRT-PCR. It was evaluated as a potential diagnostic biomarker and was predicted to participate in a circRNA-miRNA-mRNA ceRNA network.	0.5963
29847813	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	The Landscape of Circular RNA Expression Profiles in Papillary Thyroid Carcinoma Based on RNA Sequencing.		chr7:22330794-22357656-			papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; RNA-seq	chr7:22330794-22357656- was up-regulated in PTC tissues and validated by qRT-PCR. The study evaluated it among validated circRNAs as a potential diagnostic biomarker for PTC.	0.5963
29847813	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	The Landscape of Circular RNA Expression Profiles in Papillary Thyroid Carcinoma Based on RNA Sequencing.		chr21:16386665-16415895-			papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; RNA-seq	chr21:16386665-16415895- was up-regulated in PTC tissues and validated by qRT-PCR. The study evaluated it among validated circRNAs as a potential diagnostic biomarker for PTC.	0.5963
29847813	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	The Landscape of Circular RNA Expression Profiles in Papillary Thyroid Carcinoma Based on RNA Sequencing.		chr7:91924203-91957214+			papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR; RNA-seq	chr7:91924203-91957214+ was down-regulated in PTC tissues and validated by qRT-PCR. The study evaluated it among validated circRNAs as a potential diagnostic biomarker for PTC.	0.5963
29847813	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	The Landscape of Circular RNA Expression Profiles in Papillary Thyroid Carcinoma Based on RNA Sequencing.		chr2:179514891-179516047-			papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR; RNA-seq	chr2:179514891-179516047- was down-regulated in PTC tissues and validated by qRT-PCR. The study evaluated it among validated circRNAs as a potential diagnostic biomarker for PTC.	0.5963
29847813	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	The Landscape of Circular RNA Expression Profiles in Papillary Thyroid Carcinoma Based on RNA Sequencing.		chr9:16435553-16437522-			papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR; RNA-seq	chr9:16435553-16437522- was down-regulated in PTC tissues and validated by qRT-PCR. It was evaluated as a potential diagnostic biomarker and was predicted to participate in a circRNA-miRNA-mRNA ceRNA network.	0.5963
29847813	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	The Landscape of Circular RNA Expression Profiles in Papillary Thyroid Carcinoma Based on RNA Sequencing.		chr22:36006931-36007153-			papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR; RNA-seq	chr22:36006931-36007153- was down-regulated in PTC tissues and validated by qRT-PCR. It was evaluated as a potential diagnostic biomarker and was predicted to participate in a circRNA-miRNA-mRNA ceRNA network.	0.5963
29852168	Biochemical and biophysical research communications	2018	Overexpressing circular RNA hsa_circ_0002052 impairs osteosarcoma progression via inhibiting Wnt/beta-catenin pathway by regulating miR-1205/APC2 axis.	hsa_circ_0002052				osteosarcoma / OS	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0002052 is down-regulated in osteosarcoma tissues and cell lines and functions as a tumor suppressor. Its overexpression inhibits proliferation, migration, invasion and xenograft growth while promoting apoptosis. Mechanistically, it sponges miR-1205 to upregulate APC2 and inhibit Wnt/beta-catenin signaling, and its higher expression is associated with better patient survival."	0.7486
29864621	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2018	Downregulation of circular RNA hsa_circ_0001649 indicates poor prognosis for retinoblastoma and regulates cell proliferation and apoptosis via AKT/mTOR signaling pathway.	hsa_circ_0001649		hsa_circ_SHPRH	SHPRH	retinoblastoma / RB	MONDO:0008380	retinoblastoma	down-regulated	RT-qPCR	"hsa_circ_0001649 is downregulated in retinoblastoma tissues and cell lines, and reduced expression is associated with aggressive clinicopathologic features and poor overall survival. Functionally, hsa_circ_0001649 suppresses RB cell proliferation and xenograft growth while promoting apoptosis, partly through inhibition of AKT/mTOR signaling."	0.6736
29888838	Journal of viral hepatitis	2018	Differential expression profile of hepatic circular RNAs in chronic hepatitis B.	hsa_circ_0005389				chronic hepatitis B / CHB	MONDO:0005366	chronic hepatitis B virus infection	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0005389 was significantly up-regulated in CHB liver samples and was included in a predicted CHB-related ceRNA pathway with miR-4505/miR-6752-5p/miR-5787 and IRF7. The study suggests that this circRNA may contribute to CHB pathogenesis or HBV-related liver disease through circRNA-miRNA-mRNA interactions.	0.5135
29888838	Journal of viral hepatitis	2018	Differential expression profile of hepatic circular RNAs in chronic hepatitis B.	hsa_circ_0000650				chronic hepatitis B / CHB	MONDO:0005366	chronic hepatitis B virus infection	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000650 was significantly down-regulated in CHB liver samples. The study provides correlation-based support that hsa_circ_0000650 may regulate TGFB2 through miR-6873-3p in a ceRNA-like mechanism, and also predicts a hsa_circ_0000650-miR-210-5p-HBV pathway."	0.5135
29888838	Journal of viral hepatitis	2018	Differential expression profile of hepatic circular RNAs in chronic hepatitis B.	hsa_circ_0000038				chronic hepatitis B / CHB	MONDO:0005366	chronic hepatitis B virus infection	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000038 was significantly up-regulated in CHB liver samples. It was predicted to participate in a hsa_circ_0000038-miR-370/miR-939-HBV pathway, and its expression showed a negative correlation with miR-939 in CHB samples."	0.5135
29895226	"Cell cycle (Georgetown, Tex.)"	2018	Down-regulation of circ-PRKCI inhibits cell migration and proliferation in Hirschsprung disease by suppressing the expression of miR-1324 target PLCB1.	hsa_circ_0067934	circ_0067934 / CircPRKCI	hsa_circ_PRKCI	PRKCI	Hirschsprung disease / HSCR	MONDO:0018309	Hirschsprung disease	down-regulated	RT-qPCR	"circ-PRKCI is significantly down-regulated in HSCR aganglionic tissues and has potential diagnostic value for HSCR. Functionally, circ-PRKCI promotes proliferation and migration in 293T and SH-SY5Y cells, whereas its knockdown suppresses these processes. Mechanistically, it acts as a miR-1324 sponge to relieve miR-1324-mediated repression of PLCB1, forming a circ-PRKCI/miR-1324/PLCB1 regulatory axis."	0.8174
29902450	Biochemical and biophysical research communications	2018	Circular RNA circ-CBFB promotes proliferation and inhibits apoptosis in chronic lymphocytic leukemia through regulating miR-607/FZD3/Wnt/beta-catenin pathway.	hsa_circ_0000707	circ-CBFB	hsa_circ_CBFB	CBFB	chronic lymphocytic leukemia / CLL	MONDO:0004948	B-cell chronic lymphocytic leukemia	up-regulated	RT-qPCR	"circ-CBFB is upregulated in CLL cells and functions as an oncogenic circRNA. It promotes proliferation and cell cycle progression while inhibiting apoptosis through the miR-607/FZD3/Wnt/b-catenin axis, and its high expression is associated with diagnostic value and poorer survival in CLL patients."	0.7513
29914004	Cancer biomarkers : section A of Disease markers	2018	Screening and bioinformatics analysis of circular RNA expression profiles in hepatitis B-related hepatocellular carcinoma.		hsa_circRNA 100381 / circRNA_100381			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circRNA 100381/circRNA_100381 was significantly up-regulated in HBV-related HCC tissues compared with adjacent non-tumorous tissues and was validated by qRT-PCR. The study predicted interactions with five miRNAs and downstream mRNAs, suggesting a possible ceRNA-related role and potential biomarker value for HCC diagnosis and prognosis."	0.5135
29914004	Cancer biomarkers : section A of Disease markers	2018	Screening and bioinformatics analysis of circular RNA expression profiles in hepatitis B-related hepatocellular carcinoma.		hsa_circRNA 103489 / circRNA_103489			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circRNA 103489/circRNA_103489 was significantly up-regulated in HBV-related HCC tissues and was validated by qRT-PCR. The study predicted circRNA_103489 interactions with five miRNAs and related target mRNAs, implying a possible miRNA-mediated regulatory role and potential biomarker relevance."	0.5135
29914004	Cancer biomarkers : section A of Disease markers	2018	Screening and bioinformatics analysis of circular RNA expression profiles in hepatitis B-related hepatocellular carcinoma.		CircRNA_101764 / hsa_circRNA 101764			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"CircRNA_101764 was significantly down-regulated in HBV-related HCC tissues and was validated by qRT-PCR. It was the largest node in the predicted circRNA/miRNA co-expression network, mainly interacting with the miR-181 family, suggesting a potential role in HCC development through miRNA-mediated regulatory networks."	0.5135
29916745	Cancer biotherapy & radiopharmaceuticals	2018	Effects of hsa_circRBM23 on Hepatocellular Carcinoma Cell Viability and Migration as Produced by Regulating miR-138 Expression.		circRBM23	hsa_circ_RBM23	RBM23	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circRBM23 is up-regulated in HCC tissues and HCC cell lines and acts as an oncogenic circRNA. It promotes HCC cell viability, proliferation, cell cycle progression, migration, and xenograft tumor growth by regulating the tumor suppressor miR-138 and downstream vimentin and CCND3 expression. The authors suggest that circRBM23 may have prognostic and therapeutic value in HCC."	0.5761
29923236	Journal of cellular physiology	2018	Circular RNA hsa_circ_0016788 regulates hepatocellular carcinoma tumorigenesis through miR-486/CDK4 pathway.	hsa_circ_0016788		hsa_circ_TRIM11	TRIM11	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0016788 is up-regulated in HCC tissues and cell lines and functions as an oncogenic circRNA. Its knockdown suppresses proliferation, invasion, and xenograft tumor growth while promoting apoptosis, likely through the miR-486/CDK4 pathway. The study also suggests diagnostic potential for hsa_circ_0016788 in HCC, with ROC AUC of 0.851."	0.817
29928432	Oncology letters	2018	Upregulation of circ_001569 predicts poor prognosis and promotes cell proliferation in non-small cell lung cancer by regulating the Wnt/beta-catenin pathway.		circ_001569 / hsa-circ_001569			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_001569 is up-regulated in NSCLC tissues and cell lines and its high expression is associated with tumor differentiation, lymph node metastasis, TNM classification and poor survival. Functionally, circ_001569 promotes NSCLC cell proliferation, while siRNA-mediated knockdown suppresses proliferation and colony formation. Mechanistically, circ_001569 appears to activate the Wnt/beta-catenin pathway by maintaining WNT1, beta-catenin and TCF4 mRNA/protein expression."	0.6148
29928876	Biochemical and biophysical research communications	2018	Circular RNA HIPK3 promotes gallbladder cancer cell growth by sponging microRNA-124.	hsa_circ_0000284	Circular RNA HIPK3 / circHIPK3	hsa_circ_HIPK3	HIPK3	gallbladder cancer	MONDO:0005411	gallbladder cancer	up-regulated	RT-qPCR	"circHIPK3 is upregulated in human gallbladder cancer cells and tissues. Functionally, it promotes gallbladder cancer cell survival, proliferation and colony formation while suppressing apoptosis. Mechanistically, circHIPK3 acts as a miR-124 sponge, increasing ROCK1 and CDK6 expression, and may serve as a therapeutic target and diagnostic marker."	0.5434
29928882	Biochemical and biophysical research communications	2018	CircRNA circ_0026344 as a prognostic biomarker suppresses colorectal cancer progression via microRNA-21 and microRNA-31.	hsa_circ_0026344	circ_0026344			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; ISH	"circ_0026344 is down-regulated in colorectal cancer tissues and cell lines, and lower expression is associated with advanced stage, lymphoid node metastasis and poor prognosis. Functionally, circ_0026344 acts as a tumor suppressor by inhibiting CRC proliferation, invasion and xenograft growth while promoting apoptosis. Mechanistically, it sponges miR-21 and miR-31, forming a circ_0026344/miR-21/miR-31 regulatory axis in CRC progression."	0.7588
29930719	Oncology letters	2018	Preliminary investigation of the function of hsa_circ_0006215 in pancreatic cancer.	hsa_circ_0006215				pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; RNA-seq	"This study identified hsa_circ_0006215 as up-regulated in pancreatic cancer tissues and proposed it as a potential early diagnostic biomarker. Functional assays in PANC-1 cells suggested that hsa_circ_0006215 affects cell viability, migration and apoptosis. Mechanistically, the authors proposed a hsa_circ_0006215/miR-378a-3p/SERPINA4 regulatory axis."	0.6815
29938598	Autophagy	2018	Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: implications for cerebral ischemic stroke.		circRNA HECTD1 / mm9_circ_008488	hsa_circ_HECTD1	HECTD1	cerebral ischemic stroke	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; Microarray	"circHECTD1 is up-regulated in ischemic brain tissues from tMCAO mice and in plasma from AIS patients. It promotes astrocyte activation and autophagy through a circHECTD1-MIR142-TIPARP mechanism, and its knockdown reduces infarct size and improves neurological outcomes, supporting its potential as a biomarker and therapeutic target for ischemic stroke."	0.8173
29938598	Autophagy	2018	Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: implications for cerebral ischemic stroke.		circRNA HECTD1 / mm9_circ_008488	mmu_circ_Hectd1	Hectd1	cerebral ischemic stroke	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; Microarray	"circHECTD1 is up-regulated in ischemic brain tissues from tMCAO mice and in plasma from AIS patients. It promotes astrocyte activation and autophagy through a circHECTD1-MIR142-TIPARP mechanism, and its knockdown reduces infarct size and improves neurological outcomes, supporting its potential as a biomarker and therapeutic target for ischemic stroke."	0.8173
29938598	Autophagy	2018	Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: implications for cerebral ischemic stroke.		mm9_circ_002722	mmu_circ_Supt3	Supt3	ischemic stroke	MONDO:1060198	ischemic stroke	up-regulated	Microarray	"mm9_circ_002722 was identified by circRNA microarray as up-regulated in ischemic tissues from the tMCAO mouse model. The paper did not report RT-qPCR validation, interaction partners, mechanisms, or functional assays for this circRNA."	0.1155
29938598	Autophagy	2018	Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: implications for cerebral ischemic stroke.		mm9_circ_009932	mmu_circ_Tlk1	Tlk1	ischemic stroke	MONDO:1060198	ischemic stroke	up-regulated	Microarray	"mm9_circ_009932 was identified by circRNA microarray as up-regulated in ischemic tissues from the tMCAO mouse model. The paper did not report RT-qPCR validation, interaction partners, mechanisms, or functional assays for this circRNA."	0.1155
29938598	Autophagy	2018	Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: implications for cerebral ischemic stroke.		mm9_circ_014781	mmu_circ_Rims1	Rims1	ischemic stroke	MONDO:1060198	ischemic stroke	up-regulated	Microarray	"mm9_circ_014781 was identified by circRNA microarray as up-regulated in ischemic tissues from the tMCAO mouse model. The paper did not report RT-qPCR validation, interaction partners, mechanisms, or functional assays for this circRNA."	0.1155
29938598	Autophagy	2018	Novel insight into circular RNA HECTD1 in astrocyte activation via autophagy by targeting MIR142-TIPARP: implications for cerebral ischemic stroke.		mm9_circ_015633	mmu_circ_Hist1h4f	Hist1h4f	ischemic stroke	MONDO:1060198	ischemic stroke	up-regulated	Microarray	"mm9_circ_015633 was identified by circRNA microarray as up-regulated in ischemic tissues from the tMCAO mouse model. The paper did not report RT-qPCR validation, interaction partners, mechanisms, or functional assays for this circRNA."	0.1155
29943828	The Journal of pathology	2018	Circular RNA circITGA7 inhibits colorectal cancer growth and metastasis by modulating the Ras pathway and upregulating transcription of its host gene ITGA7.	hsa_circ_0026782	circITGA7	hsa_circ_ITGA7	ITGA7	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"circITGA7 is a human ITGA7-derived circRNA that is significantly downregulated in colorectal cancer tissues and cell lines and is associated with CRC progression and diagnostic potential. Functionally, circITGA7 acts as a tumour suppressor, inhibiting CRC proliferation, migration, invasion, tumour growth and metastasis. Mechanistically, cytoplasmic circITGA7 binds miR-370-3p to upregulate NF1 and suppress Ras signaling, and also promotes ITGA7 transcription by suppressing RREB1 via the Ras pathway."	0.8837
29944885	Biochemical and biophysical research communications	2018	Circ-UBR5: An exonic circular RNA and novel small nuclear RNA involved in RNA splicing.		circ-UBR5	hsa_circ_UBR5	UBR5	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"circ-UBR5 is a human exonic circRNA derived from the UBR5 gene and is significantly down-regulated in NSCLC tissues. Its low expression is associated with poor tumor differentiation, suggesting clinical value as an indicator of NSCLC differentiation degree. Mechanistically, circ-UBR5 is mainly nuclear and binds QKI, NOVA1, and U1 snRNA, suggesting a role as a novel snRNA-like circRNA in spliceosome-mediated RNA splicing regulation."	0.7514
29949786	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	Whole-Transcriptome Analysis of CD133+CD144+ Cancer Stem Cells Derived from Human Laryngeal Squamous Cell Carcinoma Cells.	hsa_circ_0005033	hg19_circ_0005033			laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"hg19_circ_0005033 is up-regulated in CD133+CD44+ LSCC stem cells. Loss-of-function experiments indicate that it promotes proliferation, migration, invasion, and cisplatin resistance, at least partly through a ceRNA mechanism involving miR-4521 and downstream mRNAs such as STAT5A."	0.5804
29949786	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	Whole-Transcriptome Analysis of CD133+CD144+ Cancer Stem Cells Derived from Human Laryngeal Squamous Cell Carcinoma Cells.		hg19_ circ_0004481			laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	dysregulated	RT-qPCR; RNA-seq	"hg19_ circ_0004481 was identified by RNA sequencing and validated by qPCR as a differentially expressed circRNA in CD133+CD44+ LSCC stem cells. The study places it within a core circRNA-miRNA-mRNA regulatory network, but does not report circRNA-specific functional or mechanistic experiments for this transcript."	0.2465
29949786	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	Whole-Transcriptome Analysis of CD133+CD144+ Cancer Stem Cells Derived from Human Laryngeal Squamous Cell Carcinoma Cells.		hg19_circ_0003610			laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	dysregulated	RT-qPCR; RNA-seq	"hg19_circ_0003610 was identified by RNA sequencing and validated by qPCR as a differentially expressed circRNA in CD133+CD44+ LSCC stem cells. The study includes it among core ceRNA-network circRNAs, but no circRNA-specific functional or mechanistic experiments were reported for this transcript."	0.2465
29949786	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	Whole-Transcriptome Analysis of CD133+CD144+ Cancer Stem Cells Derived from Human Laryngeal Squamous Cell Carcinoma Cells.		hg19_circ_0003081			laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"hg19_circ_0003081 was identified by RNA sequencing and validated by qPCR as up-regulated in CD133-CD44- TU-177 LSCC cells. It was discussed as part of the circRNA-miRNA-mRNA regulatory network distinguishing LSCC cell subpopulations, but no transcript-specific functional assay was reported."	0.2465
29949786	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	Whole-Transcriptome Analysis of CD133+CD144+ Cancer Stem Cells Derived from Human Laryngeal Squamous Cell Carcinoma Cells.		hg19_circ_0008472			laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"hg19_circ_0008472 was identified by RNA sequencing and validated by qPCR as up-regulated in CD133-CD44- TU-177 LSCC cells. It was included in the regulatory-network analysis of LSCC cell subpopulations, but no transcript-specific functional assay was reported."	0.2465
29949792	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	Genome-Wide Identification of Circular RNAs as a Novel Class of Putative Biomarkers for an Ocular Surface Disease.	hsa_circ_0085020	circ_0085020 / circ-LAPTM4B	hsa_circ_LAPTM4B	LAPTM4B	pterygium	MONDO:0005085	pterygium	up-regulated	RT-qPCR; Microarray	"hsa_circ_0085020, also referred to as circ_0085020 or circ-LAPTM4B, is an up-regulated LAPTM4B-derived circRNA in pterygium tissues and was proposed as a potential biomarker. Functional silencing experiments suggest that circ_0085020 promotes pterygium epithelial cell viability, proliferation and migration while inhibiting UV-induced apoptosis. The study predicts that circ_0085020 may participate in circRNA-miRNA-mRNA regulatory networks and focal adhesion-related processes."	0.5923
29959922	Biochemical and biophysical research communications	2018	Circular RNA HIPK3 regulates human lens epithelial cells proliferation and apoptosis by targeting the miR-193a/CRYAA axis.		circHIPK3 / circRNA HIPK3	hsa_circ_HIPK3	HIPK3	age-related cataract / ARC	MONDO:0004847	senile cataract	down-regulated	RT-qPCR; RNA-seq	"circHIPK3 is significantly down-regulated in ARC lens capsules, including cortical, nuclear and posterior subcapsular ARC. Functionally, circHIPK3 supports HLEC viability and proliferation, inhibits oxidative stress-induced apoptosis, and promotes EMT-related marker changes. Mechanistically, it regulates HLEC function through the circHIPK3/miR-193a-3p/CRYAA axis, suggesting a role in cataractogenesis."	0.7754
29967262	Cancer research	2018	CircNT5E Acts as a Sponge of miR-422a to Promote Glioblastoma Tumorigenesis.	hsa_circ_0077232	circNT5E	hsa_circ_NT5E	NT5E	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; ISH; Microarray	"circNT5E is an NT5E-derived human circular RNA that is up-regulated in glioblastoma and increases with glioma clinical grade. It promotes glioblastoma growth, proliferation, invasion, migration, and xenograft tumor formation while inhibiting apoptosis, mainly by acting as a sponge for tumor-suppressive miR-422a and regulating NT5E, SOX4, PI3KCA and downstream p-Akt/p-Smad2 signaling. Its biogenesis is promoted by ADARB2 binding to NT5E pre-mRNA flanking intronic elements."	0.8794
29969631	Biochemical and biophysical research communications	2018	CircRNA circ-BANP-mediated miR-503/LARP1 signaling contributes to lung cancer progression.		circ-BANP	hsa_circ_BANP	BANP	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circ-BANP is up-regulated in lung cancer tissues and cell lines, and high expression predicts poor survival. Functionally, circ-BANP promotes proliferation, migration, invasion and in vivo tumor growth while inhibiting apoptosis. Mechanistically, it acts through a circ-BANP/miR-503/LARP1 ceRNA axis to increase LARP1 expression and drive lung cancer progression."	0.7113
29969694	Gene	2018	A novel prognostic biomarker for pancreatic ductal adenocarcinoma: hsa_circ_0001649.	hsa_circ_0001649		hsa_circ_SHPRH	SHPRH	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	down-regulated	RT-qPCR	"This study found that hsa_circ_0001649 is down-regulated in PDAC tissues and cell lines. Higher hsa_circ_0001649 expression predicts better overall survival and serves as an independent prognostic indicator. Functionally, hsa_circ_0001649 overexpression suppresses PDAC cell proliferation and colony formation while promoting apoptosis, potentially involving caspase-3 and caspase-9 activation."	0.6527
29969755	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	Circ-ANAPC7 is Upregulated in Acute Myeloid Leukemia and Appears to Target the MiR-181 Family.		circ-ANAPC7 / hsa_circRNA_101141	hsa_circ_ANAPC7	ANAPC7	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; Microarray	"circ-ANAPC7/hsa_circRNA_101141, derived from the ANAPC7 gene locus, was significantly upregulated in AML bone marrow samples and validated by qRT-PCR. The study suggests that circ-ANAPC7 may contribute to AML pathogenesis as an oncogenic circRNA by acting as a predicted sponge for the miR-181 family and engaging cancer-related pathways. It is proposed as a promising AML biomarker and potential therapeutic target, although its clinical significance was not established due to limited follow-up."	0.585
29973691	Oncogene	2018	A circular RNA circ-DNMT1 enhances breast cancer progression by activating autophagy.		circ-DNMT1 / hsa_circRNA_102439	hsa_circ_DNMT1	Dnmt1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circ-Dnmt1 is upregulated in breast cancer cell lines and breast carcinoma tumors. It functions as an oncogenic circRNA by binding p53 and AUF1/Auf1, promoting their nuclear translocation, enhancing autophagy, increasing Dnmt1 expression, inhibiting p53 transcription, reducing senescence, and promoting proliferation, survival, and xenograft tumor growth."	0.8779
29991057	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	Salivary Circular RNAs Hsa_Circ_0001874 and Hsa_Circ_0001971 as Novel Biomarkers for the Diagnosis of Oral Squamous Cell Carcinoma.	hsa_circ_0001874				oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"Salivary hsa_circ_0001874 was up-regulated in OSCC and showed diagnostic value, especially in combination with hsa_circ_0001971. Its expression correlated with TNM stage and tumor grade, and predicted miRNA targets suggest a possible circRNA/miRNA regulatory role, although functional mechanisms were not experimentally tested."	0.6556
29991057	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	Salivary Circular RNAs Hsa_Circ_0001874 and Hsa_Circ_0001971 as Novel Biomarkers for the Diagnosis of Oral Squamous Cell Carcinoma.	hsa_circ_0001971				oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"Salivary hsa_circ_0001971 was up-regulated in OSCC and had diagnostic value alone and in combination with hsa_circ_0001874. Its expression was associated with TNM stage, and predicted miRNA interactions suggest a possible circRNA/miRNA mechanism that remains experimentally unvalidated."	0.6556
29991057	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	Salivary Circular RNAs Hsa_Circ_0001874 and Hsa_Circ_0001971 as Novel Biomarkers for the Diagnosis of Oral Squamous Cell Carcinoma.	hsa_circ_0008068				oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"Salivary hsa_circ_0008068 was up-regulated in OSCC and validated by qRT-PCR after microarray screening. It showed potential diagnostic value, but no significant associations with clinicopathological factors were reported."	0.63
29991057	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	Salivary Circular RNAs Hsa_Circ_0001874 and Hsa_Circ_0001971 as Novel Biomarkers for the Diagnosis of Oral Squamous Cell Carcinoma.	hsa_circ_0000140				oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	"Salivary hsa_circ_0000140 was down-regulated in OSCC and validated by qRT-PCR after microarray screening. It showed potential diagnostic value, but no significant associations with clinicopathological factors were reported."	0.63
29991057	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	Salivary Circular RNAs Hsa_Circ_0001874 and Hsa_Circ_0001971 as Novel Biomarkers for the Diagnosis of Oral Squamous Cell Carcinoma.	hsa_circ_0002632				oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	"Salivary hsa_circ_0002632 was down-regulated in OSCC and validated by qRT-PCR after microarray screening. It showed potential diagnostic value, but no significant associations with clinicopathological factors were reported."	0.63
29991057	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	Salivary Circular RNAs Hsa_Circ_0001874 and Hsa_Circ_0001971 as Novel Biomarkers for the Diagnosis of Oral Squamous Cell Carcinoma.	hsa_circ_0008792				oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	"Salivary hsa_circ_0008792 was down-regulated in OSCC and validated by qRT-PCR after microarray screening. It showed potential diagnostic value, but no significant associations with clinicopathological factors were reported."	0.63
30007986	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	"CircRNA8924 Promotes Cervical Cancer Cell Proliferation, Migration and Invasion by Competitively Binding to MiR-518d-5p /519-5p Family and Modulating the Expression of CBX8."	hsa_circ_0141539	circRNA8924	hsa_circ_Clorf116	Clorf116	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"circRNA8924 is up-regulated in cervical cancer tissues and correlates with more aggressive clinicopathological features. It promotes cervical cancer cell proliferation, cell cycle progression, migration and invasion by acting as a ceRNA for the miR-518d-5p/519-5p family and increasing CBX8 expression. The study proposes circRNA8924 as a potential diagnostic/progression biomarker and therapeutic target in cervical cancer."	0.7404
30010402	DNA and cell biology	2018	hsa_circ_0000177-miR-638-FZD7-Wnt Signaling Cascade Contributes to the Malignant Behaviors in Glioma.	hsa_circ_0000177				glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"hsa_circ_0000177 is upregulated in glioma tissues and cell lines, and high expression is associated with poor prognosis. Functionally, it promotes glioma proliferation, invasion, and xenograft tumor growth. Mechanistically, it sponges miR-638 to upregulate FZD7 and activate Wnt signaling."	0.7126
30015883	International journal of oncology	2018	Circular RNA_MTO1 suppresses breast cancer cell viability and reverses monastrol resistance through regulating the TRAF4/Eg5 axis.		circRNA-MTO1 / hsa-circRNA-007874	hsa_circ_MTO1	MTO1	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	"circRNA-MTO1 is down-regulated in monastrol-resistant breast cancer cells. Its overexpression suppresses breast cancer cell viability, enhances monastrol cytotoxicity, and reverses monastrol resistance by binding TRAF4 and inhibiting TRAF4-mediated Eg5 protein translation."	0.6503
30015883	International journal of oncology	2018	Circular RNA_MTO1 suppresses breast cancer cell viability and reverses monastrol resistance through regulating the TRAF4/Eg5 axis.		circRNA-100438			breast cancer / BC	MONDO:0007254	breast cancer	dysregulated	RT-qPCR; Microarray	"circRNA-100438 was identified by microarray and RT-qPCR as dysregulated between monastrol-resistant and parental breast cancer cells. Unlike circRNA-MTO1, preliminary silencing experiments suggested no significant effect on breast cancer cell viability or monastrol resistance, and its role remains unclear."	0.1904
30016668	Gene	2018	Decreased circular RNA hsa_circ_0001649 predicts unfavorable prognosis in glioma and exerts oncogenic properties in vitro and in vivo.	hsa_circ_0001649		hsa_circ_SHPRH	SHPRH	glioma	MONDO:0021042	glioma	down-regulated	RT-qPCR	"hsa_circ_0001649 is down-regulated in glioma tissues and cell lines, and its decreased expression is associated with larger tumor size, advanced WHO grade and unfavorable overall survival. Functionally, restoring hsa_circ_0001649 suppresses glioma cell proliferation, colony formation and xenograft tumor growth while promoting apoptosis through the Bcl-2/caspase-3 pathway, supporting its role as a tumor-suppressive prognostic and therapeutic target."	0.6736
30017188	Biochemical and biophysical research communications	2018	YAP1 inhibits circRNA-000425 expression and thus promotes oncogenic activities of miR-17 and miR-106.		circRNA-000425	hsa_circ_HNRNPH1	HNRNPH1	gastric cancer / GC	MONDO:0001056	gastric cancer	unknown	RT-qPCR; Microarray	"This study identifies circRNA-000425 as a YAP1-repressed circRNA in gastric cancer cell models. circRNA-000425 binds miR-17 and miR-106b, relieves their suppression of p21 and BIM, and inhibits miR-17-induced cancer cell growth, supporting a tumor-suppressive role within the Hippo-YAP1-associated regulatory context."	0.717
30017736	Gene	2018	Upregulation of circular RNA hsa_circ_0007534 predicts unfavorable prognosis for NSCLC and exerts oncogenic properties in vitro and in vivo.	hsa_circ_0007534		hsa_circ_DDX42	DDX42	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0007534 is up-regulated in NSCLC tissues and cell lines and its high expression is associated with lymph node invasion, advanced TNM stage and poor overall survival. Functionally, it promotes NSCLC cell proliferation, colony formation, migration, invasion, EMT and xenograft tumor growth while inhibiting apoptosis, suggesting an oncogenic and prognostic role."	0.6742
30025927	Gene	2018	"Transcriptomic analysis of high-throughput sequencing about circRNA, lncRNA and mRNA in bladder cancer."		circRNA PGM5 / circ-PGM5	hsa_circ_PGM5	PGM5	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	dysregulated	RT-qPCR; RNA-seq	circRNA PGM5 was identified as a dysregulated circRNA in bladder cancer and validated by RT-qPCR. The study predicts that circRNA PGM5 may act through ceRNA-related miRNA recognition elements and may be functionally linked to FAM129A and p53-mediated apoptosis.	0.4032
30025927	Gene	2018	"Transcriptomic analysis of high-throughput sequencing about circRNA, lncRNA and mRNA in bladder cancer."		KIAA1462	hsa_circ_KIAA1462	KIAA1462	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	dysregulated	RT-qPCR; RNA-seq	"KIAA1462 was one of the selected circRNA-associated transcripts from the sequencing dataset and its differential expression in bladder cancer tissues was confirmed by RT-qPCR. The study suggests it may have biomarker potential, but no specific mechanism was experimentally defined."	0.4032
30025927	Gene	2018	"Transcriptomic analysis of high-throughput sequencing about circRNA, lncRNA and mRNA in bladder cancer."		circRNA IGHG2	hsa_circ_IGHG2	IGHG2	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	dysregulated	RNA-seq	"circRNA IGHG2 was selected from the sequencing-based circRNA candidates, but qRT-PCR amplification failed. Therefore, its bladder cancer association remains supported only by high-throughput prediction rather than successful experimental validation."	0.1768
30025927	Gene	2018	"Transcriptomic analysis of high-throughput sequencing about circRNA, lncRNA and mRNA in bladder cancer."		circRNA MOCOS	hsa_circ_MOCOS	MOCOS	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	dysregulated	RNA-seq	"circRNA MOCOS was included in the predicted ceRNA network of differentially expressed circRNAs in bladder cancer. The study proposes a circRNA MOCOS/miR-214-3p/E2F3 regulatory relationship that may contribute to bladder cancer progression, but this was not experimentally validated by RT-qPCR or functional assays."	0.1768
30025927	Gene	2018	"Transcriptomic analysis of high-throughput sequencing about circRNA, lncRNA and mRNA in bladder cancer."		circ-ACER2	hsa_circ_ACER2	ACER2	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	dysregulated	RNA-seq	"circ-ACER2 was included in the predicted ceRNA network of dysregulated circRNAs in bladder cancer. It was predicted to sponge several miRNAs, suggesting a potential role in bladder cancer carcinogenesis, but no direct experimental validation was reported."	0.1768
30025927	Gene	2018	"Transcriptomic analysis of high-throughput sequencing about circRNA, lncRNA and mRNA in bladder cancer."		circRNA UNG	hsa_circ_UNG	UNG	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	dysregulated	RNA-seq	"circRNA UNG was identified through RNA-seq and co-expression analysis as a dysregulated circRNA potentially linked to MYBL2. The authors suggest it may contribute to bladder cancer progression through cell cycle-related mechanisms, but this remains a bioinformatic prediction."	0.1768
30029881	Biochemical and biophysical research communications	2018	Circular RNA circ_0001649 acts as a prognostic biomarker and inhibits NSCLC progression via sponging miR-331-3p and miR-338-5p.	hsa_circ_0001649	circ_0001649	hsa_circ_SHPRH	SHPRH	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"circ_0001649 is a SHPRH-derived human circRNA downregulated in NSCLC tissues and cell lines. It acts as a tumor suppressor by inhibiting proliferation, migration, invasion, tumor growth and lung metastasis, partly through sponging miR-331-3p and miR-338-5p. Clinically, low circ_0001649 expression is associated with advanced TNM stage, lymph node metastasis and poorer overall survival."	0.7483
30037980	Molecular and cellular biology	2018	Role of Circular RNA DLEU2 in Human Acute Myeloid Leukemia.	hsa_circ_0000488	circRNA-DLEU2 / circDLEU2	hsa_circ_DLEU2	DLEU2	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; Microarray	"circRNA-DLEU2/hsa_circ_0000488 is up-regulated in AML bone marrow samples and AML cell lines. It promotes AML cell proliferation and tumor formation while inhibiting apoptosis, acting through a circRNA-DLEU2/miR-496/PRKACB regulatory axis. The study suggests circRNA-DLEU2 may be a biomarker and therapeutic target for AML."	0.8195
30054916	Journal of cellular physiology	2019	Circular RNA circRNA_15698 aggravates the extracellular matrix of diabetic nephropathy mesangial cells via miR-185/TGF-beta1.	mmu_circ_0015698	circRNA_15698			diabetic nephropathy / DN	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR; Microarray	"circRNA_15698 is upregulated in db/db diabetic nephropathy mouse kidney tissue and in high glucose-treated mouse mesangial cells. It mainly localizes to the cytoplasm, acts as a sponge for miR-185, and promotes TGF-beta1 and ECM-related protein synthesis, thereby aggravating extracellular matrix accumulation in diabetic nephropathy."	0.599
30057315	Biochemical and biophysical research communications	2018	CircRNA circHIPK3 serves as a prognostic marker to promote glioma progression by regulating miR-654/IGF2BP3 signaling.		circHIPK3	hsa_circ_HIPK3	HIPK3	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in human glioma tissues and cell lines, and high expression predicts poor prognosis. Functionally, circHIPK3 promotes glioma proliferation, invasion and xenograft tumor growth by regulating the miR-654/IGF2BP3 axis, suggesting an oncogenic role and potential therapeutic relevance."	0.7113
30070690	Journal of cellular physiology	2019	CircHIPK3 promotes proliferation and invasion in nasopharyngeal carcinoma by abrogating miR-4288-induced ELF3 inhibition.		circHIPK3 / circular homeodomain interacting protein kinase 3	hsa_circ_HIPK3	HIPK3	nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; ISH	"circHIPK3 is up-regulated in nasopharyngeal carcinoma tissues and cell lines, and high expression predicts worse OS and DMFS. Functionally, circHIPK3 promotes NPC proliferation, migration, invasion, tumor growth, and metastasis. Mechanistically, it acts as a ceRNA for miR-4288 to relieve miR-4288-mediated inhibition of ELF3."	0.7369
30071511	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	Microarray Analysis of Differentially Expressed Profiles of Circular RNAs in a Mouse Model of Intestinal Ischemia/Reperfusion Injury with and Without Ischemic Postconditioning.		circRNA_012412	mmu_circ_Rn45s	Rn45s	ischemia/reperfusion injury	MONDO:0005203	ischemia reperfusion injury	down-regulated	RT-qPCR; Microarray	"circRNA_012412 is a mouse Rn45s-derived circRNA that is down-regulated in intestinal I/R injury and restored by ischemic postconditioning. The study proposes that circRNA_012412 may function as a protective factor through predicted circRNA-miRNA-mRNA ceRNA axes involving miR-7649-3p, miR-3473c, miR-6991-3p and downstream mRNAs Sertad1, Nudcd1 and Jam2."	0.5608
30071511	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	Microarray Analysis of Differentially Expressed Profiles of Circular RNAs in a Mouse Model of Intestinal Ischemia/Reperfusion Injury with and Without Ischemic Postconditioning.		circRNA_016863	mmu_circ_Rn45s	Rn45s	ischemia/reperfusion injury	MONDO:0005203	ischemia reperfusion injury	down-regulated	RT-qPCR; Microarray	"circRNA_016863 is a mouse Rn45s-derived circRNA that is down-regulated in intestinal I/R injury and restored by ischemic postconditioning. The authors identify it as a possible protective factor and predict that it may participate in circRNA-miRNA-mRNA regulatory mechanisms, although no specific circRNA_016863 miRNA or downstream mRNA axis is named in the provided text."	0.5608
30072582	Molecular cancer research : MCR	2018	Circular RNA ciRS-7 Maintains Metastatic Phenotypes as a ceRNA of miR-1299 to Target MMPs.		ciRS-7 / CDR1as	hsa_circ_CDR1	CDR1	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"ciRS-7 is up-regulated in TNBC tissues and cells and is associated with aggressive clinicopathological features. It promotes TNBC migration, invasion, and metastasis by acting as a ceRNA for miR-1299, thereby enhancing MMP2/MMP17 and MMP family expression."	0.8278
30086881	Biochemical and biophysical research communications	2018	Overexpression of circular RNA circ_001569 indicates poor prognosis in hepatocellular carcinoma and promotes cell growth and metastasis by sponging miR-411-5p and miR-432-5p.		circ_001569			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_001569 is up-regulated in HCC tissues and cell lines, and its high expression is associated with larger tumor size, advanced TNM stage and poor postoperative prognosis. Functionally, it promotes HCC cell growth, migration, invasion, tumor formation and lung metastasis. Mechanistically, circ_001569 acts as a sponge for miR-411-5p and miR-432-5p, and its oncogenic activity is partially dependent on regulation of these miRNAs."	0.7483
30098434	Gene	2018	Downregulation of circular RNA hsa_circ_0000144 inhibits bladder cancer progression via stimulating miR-217 and suppressing RUNX2 expression.	hsa_circ_0000144		hsa_circ_SLAMF6	SLAMF6	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000144 is up-regulated in bladder cancer tissues and cell lines, and high expression is associated with poor patient survival. Functionally, it promotes bladder cancer proliferation, invasion, cell-cycle progression, and xenograft tumor growth. Mechanistically, it functions as a ceRNA by sponging miR-217 to increase RUNX2 expression."	0.7631
30103946	Biochemical and biophysical research communications	2018	Upregulated circular RNA circ_0016760 indicates unfavorable prognosis in NSCLC and promotes cell progression through miR-1287/GAGE1 axis.	hsa_circ_0016760	circ_0016760			Non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0016760 is upregulated in NSCLC tissues and cell lines, and its high expression is associated with advanced TNM stage, lymph node metastasis, and poor overall survival. Functionally, circ_0016760 promotes proliferation, colony formation, migration, invasion, and xenograft tumor growth while inhibiting apoptosis. Mechanistically, it acts as a ceRNA for miR-1287 to increase GAGE1 expression, forming a circ_0016760/miR-1287/GAGE1 regulatory axis that contributes to NSCLC progression."	0.7412
30120213	Journal of medical genetics	2019	Global microarray profiling identified hsa_circ_0064428 as a potential immune-associated prognosis biomarker for hepatocellular carcinoma.	hsa_circ_0064428				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	dysregulated	RT-qPCR; Microarray	"Plasma hsa_circ_0064428 was identified by circRNA microarray and validated by qRT-PCR as differentially expressed between HCC patients with high and low tumour-infiltrating lymphocytes. Higher hsa_circ_0064428 expression was associated with poorer overall survival, lower TIL levels, larger tumour size, advanced stage and metastasis, supporting its role as a non-invasive prognostic biomarker for HCC. Bioinformatics analysis suggested that hsa_circ_0064428 may interact with several miRNAs, but the molecular mechanism was not experimentally validated."	0.5534
30128795	Functional & integrative genomics	2019	Comprehensive analysis of the whole coding and non-coding RNA transcriptome expression profiles and construction of the circRNA-lncRNA co-regulated ceRNA network in laryngeal squamous cell carcinoma.	hsa_circ_0008832				laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	hsa_circ_0008832 was detected as a dysregulated circRNA in LSCC by circRNA microarray and was confirmed to be downregulated in 20 paired LSCC clinical samples by qRT-PCR. No specific functional mechanism or regulatory axis was experimentally characterized for this circRNA in the article.	0.3588
30128795	Functional & integrative genomics	2019	Comprehensive analysis of the whole coding and non-coding RNA transcriptome expression profiles and construction of the circRNA-lncRNA co-regulated ceRNA network in laryngeal squamous cell carcinoma.	hsa_circ_0033988				laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0033988 was downregulated in LSCC samples and validated by qRT-PCR. It was the highest-degree node in the circRNA-mediated ceRNA network and was predicted to act as an MRE sponge in a circRNA-miRNA-mRNA regulatory network, with functional annotation implicating fatty acid degradation, MAPK signaling, and cancer-related pathways."	0.4032
30128795	Functional & integrative genomics	2019	Comprehensive analysis of the whole coding and non-coding RNA transcriptome expression profiles and construction of the circRNA-lncRNA co-regulated ceRNA network in laryngeal squamous cell carcinoma.	hsa_circ_0001445				laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	hsa_circ_0001445 was detected as a dysregulated circRNA in LSCC by circRNA microarray and was confirmed to be downregulated in 20 paired LSCC clinical samples by qRT-PCR. The paper did not report a specific mechanistic or functional validation for this circRNA.	0.3588
30128795	Functional & integrative genomics	2019	Comprehensive analysis of the whole coding and non-coding RNA transcriptome expression profiles and construction of the circRNA-lncRNA co-regulated ceRNA network in laryngeal squamous cell carcinoma.	hsa_circ_0007013				laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0007013 was validated as downregulated in LSCC tissues. Bioinformatics analysis mapped it to a circRNA-lncRNA co-regulated ceRNA module with LINC00657, involving miR-93-5P/TGFBR2 and miR-106b-5P/KDR interactions and implicating TGF-beta/RTK-related EMT, proliferation, and metastasis programs."	0.4032
30129184	Journal of cellular biochemistry	2018	Circ_0056618 and CXCR4 act as competing endogenous in gastric cancer by regulating miR-206.	hsa_circ_0056618	circ_0056618			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circ_0056618 is up-regulated in gastric cancer tissues and cell lines, and high expression is associated with poor patient survival. Functionally, circ_0056618 promotes gastric cancer cell proliferation, invasion, migration, and metastasis. Mechanistically, it acts as a ceRNA by sponging miR-206 to increase CXCR4 expression, suggesting prognostic and therapeutic relevance."	0.7357
30132886	Journal of cellular physiology	2019	CircRBMS3 promotes gastric cancer tumorigenesis by regulating miR-153-SNAI1 axis.	hsa_circ_0064644	circRBMS3	hsa_circ_RBMS3	RBMS3	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circRBMS3/hsa_circ_0064644 is upregulated in gastric cancer tissues and cell lines and is associated with advanced disease features and poor overall survival. Functionally, circRBMS3 promotes gastric cancer cell proliferation, invasion, and xenograft tumor growth. Mechanistically, it acts through the miR-153/SNAI1 axis, increasing SNAI1 expression by inhibiting miR-153."	0.8057
30138108	Biological chemistry	2018	Aberrant expression of hsa_circ_0025036 in lung adenocarcinoma and its potential roles in regulating cell proliferation and apoptosis.	hsa_circ_0025036		hsa_circ_FoxM1	FoxM1	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0025036 is up-regulated in lung adenocarcinoma tissues and correlates with aggressive clinicopathological characteristics. Functionally, it promotes proliferation and suppresses apoptosis in lung adenocarcinoma cells, probably through a ceRNA-like hsa_circ_0025036/miR-198/SHMT1 and TGF-alpha axis. The study suggests hsa_circ_0025036 as a potential prognostic biomarker and therapeutic target."	0.7968
30139516	Biochemical and biophysical research communications	2018	Downregulation of hsa_circ_0007534 suppresses breast cancer cell proliferation and invasion by targeting miR-593/MUC19 signal pathway.	hsa_circ_0007534		hsa_circ_DDX42	DDX42	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"hsa_circ_0007534 is upregulated in breast cancer tissues and cell lines and functions as an oncogenic circRNA. Its knockdown suppresses BC cell viability, proliferation, colony formation and invasion, promotes apoptosis, and alters cell-cycle distribution. Mechanistically, hsa_circ_0007534 sponges miR-593 to relieve repression of MUC19, forming a hsa_circ_0007534/miR-593/MUC19 regulatory axis that promotes BC progression."	0.7595
30142548	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2018	Overexpression of hsa_circ_0007534 predicts unfavorable prognosis for osteosarcoma and regulates cell growth and apoptosis by affecting AKT/GSK-3beta signaling pathway.	hsa_circ_0007534	circ-0007534			osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"hsa_circ_0007534 is up-regulated in osteosarcoma tissues and cell lines, and its high expression is associated with larger tumor size, poorer differentiation and worse overall survival. Functionally, it promotes OS cell proliferation, colony formation and xenograft growth while inhibiting apoptosis, at least partly through AKT/GSK-3beta signaling and Bcl-2/caspase-3-related apoptotic regulation."	0.6742
30146736	Journal of cellular physiology	2019	Circular RNA circ-VANGL1 as a competing endogenous RNA contributes to bladder cancer progression by regulating miR-605-3p/VANGL1 pathway.	hsa_circ_0002623	circ-VANGL1	hsa_circ_VANGL1	VANGL1	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"circ-VANGL1 is up-regulated in bladder cancer tissues and cell lines and high expression is associated with poorer survival and aggressive clinical features. Functionally, it promotes bladder cancer proliferation, cell-cycle progression, migration, invasion, and xenograft tumor growth. Mechanistically, circ-VANGL1 functions as a ceRNA for miR-605-3p to increase VANGL1 expression, forming the circ-VANGL1/miR-605-3p/VANGL1 axis."	0.8069
30152863	Journal of cellular physiology	2019	Circular RNA of vimentin expression as a valuable predictor for acute myeloid leukemia development and prognosis.		Circ-vimentin / Circ-VIM	hsa_circ_VIM	VIM	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"Circ-VIM is significantly upregulated in AML BMNC samples and its high expression distinguishes AML patients from healthy controls. High Circ-VIM expression is associated with worse OS and LFS and is an independent poor prognostic factor. The study also reports a positive correlation between Circ-VIM and its host gene VIM, suggesting a possible role in AML progression through VIM regulation."	0.4992
30167605	Metallomics : integrated biometal science	2018	"Circ008913, via miR-889 regulation of DAB2IP/ZEB1, is involved in the arsenite-induced acquisition of CSC-like properties by human keratinocytes in carcinogenesis."		hsa_circRNA_008913	hsa_circ_ADAT1	ADAT1	skin oncogenesis	MONDO:0002898	skin cancer	down-regulated	RT-qPCR; Microarray	"circ008913 is down-regulated during arsenite-induced malignant transformation of human HaCaT keratinocytes. It acts as a cytoplasmic ceRNA sponge for miR-889, regulating DAB2IP/ZEB1 and thereby inhibiting CSC-like properties, colony formation, invasion, migration, and xenograft tumor growth."	0.7328
30168369	Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine	2018	Network analyses-based identification of circular ribonucleic acid-related pathways in intrahepatic cholangiocarcinoma.		circ2174 / circ002174	hsa_circ_IGHE	IGHE	intrahepatic cholangiocarcinoma / CCA	MONDO:0003210	intrahepatic cholangiocarcinoma	up-regulated	RNA-seq	"circ2174 is significantly increased in intrahepatic cholangiocarcinoma tissues based on RNA-seq analysis. Network and bioinformatics analyses suggest that circ2174 may function as a miR149 sponge to modulate Oct-2 and downstream interleukin-16 signaling, implicating it in immune/inflammatory regulatory pathways in cholangiocarcinoma. Functional support includes siRNA-mediated modulation of circ2174 in SG231 CCA cells with concomitant reduction of Oct-2 expression."	0.4997
30172209	Molecular immunology	2018	Using plasma circRNA_002453 as a novel biomarker in the diagnosis of lupus nephritis.		circRNA_002453 / hsa_circRNA_002453	hsa_circ_RAD18	RAD18	lupus nephritis / LN	MONDO:0005556	lupus nephritis	up-regulated	RT-qPCR; Microarray	"Plasma circRNA_002453 is significantly upregulated in lupus nephritis and also elevated in SLE compared with RA patients and healthy controls. Its level correlates positively with renal involvement indicators and shows strong diagnostic performance for LN, supporting its role as a potential noninvasive biomarker rather than a functionally characterized mechanistic regulator."	0.5662
30173892	Biochemical and biophysical research communications	2018	CircRNA_100290 promotes colorectal cancer progression through miR-516b-induced downregulation of FZD4 expression and Wnt/beta-catenin signaling.		circRNA_100290			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH	"circRNA_100290 is up-regulated in colorectal cancer tissues and cell lines and its high expression is associated with metastasis and worse prognosis. Functionally, circRNA_100290 promotes CRC cell proliferation, migration, invasion, metastasis and tumor growth while suppressing apoptosis. Mechanistically, it acts as a cytoplasmic ceRNA that sponges miR-516b to increase FZD4 expression and activate Wnt/beta-catenin signaling."	0.7474
30176158	"Cell cycle (Georgetown, Tex.)"	2018	CircRNA hsa_circ_100395 regulates miR-1228/TCF21 pathway to inhibit lung cancer progression.	hsa_circ_0015278	hsa_circ_100395	hsa_circ_KLHL20	KLHL20	lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_100395 is downregulated in lung cancer tissues and functions as a tumor suppressor. It inhibits proliferation, cell-cycle progression, migration, invasion, and xenograft tumor growth by sponging miR-1228 and regulating TCF21. Clinically, lower hsa_circ_100395 expression is associated with higher TNM stage, metastasis, and poorer prognosis."	0.7855
30182381	Cell proliferation	2018	CDR1as is overexpressed in laryngeal squamous cell carcinoma to promote the tumour's progression via miR-7 signals.		ciRS-7 / CDR1as	hsa_circ_CDR1	CDR1	laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR	"CDR1as is up-regulated in LSCC tissues and acts as an oncogenic circRNA. It promotes proliferation, cell-cycle progression, migration, invasion, EMT, and xenograft tumour growth by sponging miR-7 and increasing CCNE1 and PIK3CD expression. Clinically, high CDR1as expression is associated with advanced disease features and shorter survival, suggesting biomarker potential."	0.6745
30182433	Molecular carcinogenesis	2018	Comprehensive analysis of differential circular RNA expression in a mouse model of colitis-induced colon carcinoma.		mmu_circRNA_001801	mmu_circ_Wdr49	Wdr49	colitis	MONDO:0005292	colitis	up-regulated	RT-qPCR; RNA-seq	"mmu_circRNA_001801, derived from Wdr49, was up-regulated in AOM/DSS mouse colonic tumor tissue and validated by RT-PCR. The study suggests that altered circRNAs may participate in colitis-associated colorectal carcinogenesis through predicted circRNA-miRNA-mRNA regulatory interactions."	0.5802
30182433	Molecular carcinogenesis	2018	Comprehensive analysis of differential circular RNA expression in a mouse model of colitis-induced colon carcinoma.		mmu_circRNA_002987	mmu_circ_Sema3f	Sema3f	colitis	MONDO:0005292	colitis	up-regulated	RT-qPCR; RNA-seq	"mmu_circRNA_002987, derived from Sema3f, was up-regulated in AOM/DSS mouse colonic tumor tissue and validated by RT-PCR. Its potential role was inferred from bioinformatic circRNA-miRNA-mRNA network and pathway analyses."	0.5802
30182433	Molecular carcinogenesis	2018	Comprehensive analysis of differential circular RNA expression in a mouse model of colitis-induced colon carcinoma.		mmu_circRNA_001155	mmu_circ_Nrip1	Nrip1	colitis	MONDO:0005292	colitis	up-regulated	RT-qPCR; RNA-seq	"mmu_circRNA_001155, derived from Nrip1, was up-regulated in AOM/DSS mouse colonic tumor tissue. The article links its dysregulation to predicted circRNA-miRNA-mRNA networks and possible involvement in colitis-induced colon carcinoma."	0.5802
30182433	Molecular carcinogenesis	2018	Comprehensive analysis of differential circular RNA expression in a mouse model of colitis-induced colon carcinoma.		mmu_circRNA_000287	mmu_circ_Nr1h4	Nr1h4	colitis	MONDO:0005292	colitis	down-regulated	RT-qPCR; RNA-seq	"mmu_circRNA_000287/circRNA_000287, derived from Nr1h4, was down-regulated in AOM/DSS mouse colonic tumor tissue and its back-splice junction was confirmed by Sanger sequencing. The authors highlighted it as a potential key circRNA in a predicted circRNA-miRNA-mRNA mechanism for colitis-associated colorectal cancer."	0.6148
30182433	Molecular carcinogenesis	2018	Comprehensive analysis of differential circular RNA expression in a mouse model of colitis-induced colon carcinoma.		mmu_circRNA_003037	mmu_circ_Heph	Heph	colitis	MONDO:0005292	colitis	down-regulated	RT-qPCR; RNA-seq	"mmu_circRNA_003037, derived from Heph, was down-regulated in AOM/DSS mouse colonic tumor tissue. It was validated by RT-PCR and its junction sequence was confirmed by Sanger sequencing, supporting its differential expression in colitis-associated colon carcinogenesis."	0.6148
30182433	Molecular carcinogenesis	2018	Comprehensive analysis of differential circular RNA expression in a mouse model of colitis-induced colon carcinoma.		mmu_circRNA_001226	mmu_circ_Btnl1	Btnl1	colitis	MONDO:0005292	colitis	down-regulated	RT-qPCR; RNA-seq	"mmu_circRNA_001226, derived from Btnl1, was down-regulated in AOM/DSS mouse colonic tumor tissue and validated by RT-PCR and Sanger sequencing. It was highlighted as a major node in the predicted circRNA-miRNA-mRNA network and may regulate colitis-associated colorectal cancer through binding multiple miRNAs, including mmu-miR-1192, mmu-miR-1224-5p, mmu-miR-25-3p, mmu-miR-23a-3p, and mmu-miR-192-3p."	0.6148
30182731	Epigenomics	2018	Circular RNA hsa_circ_0072995 promotes breast cancer cell migration and invasion through sponge for miR-30c-2-3p.	hsa_circ_0072995		hsa_circ_ARHGEF28	ARHGEF28	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0072995 is up-regulated in MDA-MB-231 breast cancer cells compared with MCF-7 cells. It promotes breast cancer cell migration and invasion, at least partly by acting as a sponge for miR-30c-2-3p, and it may also regulate its host gene ARHGEF28. The study suggests hsa_circ_0072995 may be a novel biomarker related to breast cancer metastasis."	0.7006
30190130	Biochemical and biophysical research communications	2018	CircRNA circ-ITCH suppresses papillary thyroid cancer progression through miR-22-3p/CBL/beta-catenin pathway.		circ-ITCH	hsa_circ_ITCH	ITCH	papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	down-regulated	RT-qPCR	"circ-ITCH is downregulated in papillary thyroid cancer tissues and cell lines. Functionally, circ-ITCH suppresses PTC cell proliferation and invasion, promotes apoptosis, and inhibits xenograft tumor growth. Mechanistically, it sponges miR-22-3p to upregulate CBL, thereby suppressing beta-catenin/Wnt signaling."	0.7126
30191736	Epigenomics	2018	Screening circular RNA related to chemotherapeutic resistance in osteosarcoma by RNA sequencing.	hsa_circ_0004674				osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; RNA-seq	"hsa circ 0004674 was the most upregulated circRNA in chemoresistant osteosarcoma cell lines and was also increased in OS tissues, especially chemoresistant tissues. Its high expression was associated with shorter overall survival, and predicted ceRNA axes involving miR-490-3p/ABCC2 and miR-1254/EGFR suggest a possible role in OS chemoresistance."	0.6238
30191736	Epigenomics	2018	Screening circular RNA related to chemotherapeutic resistance in osteosarcoma by RNA sequencing.	hsa_circ_0068458				osteosarcoma / OS	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; RNA-seq	"hsa circ 0068458 was identified as the most downregulated circRNA in chemoresistant osteosarcoma cell lines compared with chemosensitive controls. Its downregulation was validated by qRT-PCR in cell lines, but the study did not further characterize its clinical significance or molecular mechanism."	0.4276
30202956	Toxicological sciences : an official journal of the Society of Toxicology	2018	The CDR1as/miR-7/TGFBR2 Axis Modulates EMT in Silica-Induced Pulmonary Fibrosis.		CDR1as / ciRS-7			silicosis	MONDO:0005960	silicosis	up-regulated	RT-qPCR	"CDR1as is up-regulated in silica-treated human pulmonary epithelial cells and promotes silica-induced EMT. Mechanistically, CDR1as sponges miR-7, thereby relieving repression of TGFBR2 and increasing TGFBR2/p-Smad2/3 signaling. The CDR1as/miR-7/TGFBR2 axis is proposed as a potential therapeutic target in silica-induced pulmonary fibrosis."	0.5695
30205959	Biochemical and biophysical research communications	2018	Global identification of circular RNAs in chronic myeloid leukemia reveals hsa_circ_0080145 regulates cell proliferation by sponging miR-29b.	hsa_circ_0080145	circ_0080145			chronic myeloid leukemia / CML	MONDO:0011996	"chronic myelogenous leukemia, BCR-ABL1 positive"	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0080145 is significantly up-regulated in CML patient samples and CML cell lines. It promotes CML cell proliferation by acting as a miR-29b sponge within a ceRNA regulatory network and may have biomarker potential for CML prognosis or therapy.	0.6676
30205959	Biochemical and biophysical research communications	2018	Global identification of circular RNAs in chronic myeloid leukemia reveals hsa_circ_0080145 regulates cell proliferation by sponging miR-29b.	hsa_circ_0134501				chronic myeloid leukemia / CML	MONDO:0011996	"chronic myelogenous leukemia, BCR-ABL1 positive"	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0134501 was among the top differentially expressed circRNAs selected from CML high-throughput sequencing data and validated by qRT-PCR. The article indicates it is highly expressed in CML, but does not provide a specific mechanistic or functional validation for this circRNA."	0.4032
30205959	Biochemical and biophysical research communications	2018	Global identification of circular RNAs in chronic myeloid leukemia reveals hsa_circ_0080145 regulates cell proliferation by sponging miR-29b.	hsa_circ_0013745	circ_0013745			chronic myeloid leukemia / CML	MONDO:0011996	"chronic myelogenous leukemia, BCR-ABL1 positive"	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0013745 was selected from the top 20 differentially expressed circRNAs in CML and its expression pattern was validated by qRT-PCR. The study does not report a circRNA-specific mechanism or functional assay for hsa_circ_0013745.	0.4032
30205959	Biochemical and biophysical research communications	2018	Global identification of circular RNAs in chronic myeloid leukemia reveals hsa_circ_0080145 regulates cell proliferation by sponging miR-29b.	hsa_circ_0024002	circ_0024002			chronic myeloid leukemia / CML	MONDO:0011996	"chronic myelogenous leukemia, BCR-ABL1 positive"	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0024002 was identified as a highly expressed differentially expressed circRNA in CML and its expression was validated by qRT-PCR. It was also one of the top 20 aberrantly expressed circRNAs with many predicted miRNA targets, but the study did not experimentally validate a specific miRNA interaction or biological function for it."	0.4032
30205959	Biochemical and biophysical research communications	2018	Global identification of circular RNAs in chronic myeloid leukemia reveals hsa_circ_0080145 regulates cell proliferation by sponging miR-29b.	hsa_circ_0062982	circ_0062982			chronic myeloid leukemia / CML	MONDO:0011996	"chronic myelogenous leukemia, BCR-ABL1 positive"	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0062982 was selected from the top 20 differentially expressed circRNAs in CML and showed a qRT-PCR validation pattern consistent with sequencing. The paper does not report a specific molecular mechanism or functional validation for hsa_circ_0062982.	0.4032
30205959	Biochemical and biophysical research communications	2018	Global identification of circular RNAs in chronic myeloid leukemia reveals hsa_circ_0080145 regulates cell proliferation by sponging miR-29b.	hsa_circ_0037781				chronic myeloid leukemia / CML	MONDO:0011996	"chronic myelogenous leukemia, BCR-ABL1 positive"	dysregulated	RNA-seq	"hsa_circ_0037781 was included among the top 20 aberrantly expressed circRNAs in CML and was predicted to have many target miRNAs in the circRNA-miRNA network. No qRT-PCR validation, specific expression direction, or experimental functional assay was reported for this circRNA."	0.1768
30207835	Cancer biology & therapy	2019	Circular RNA ciRS-7 triggers the migration and invasion of esophageal squamous cell carcinoma via miR-7/KLF4 and NF-kappaB signals.		ciRS-7 / ciRS7	hsa_circ_CDR1	CDR1	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"ciRS-7 is up-regulated in ESCC tissues and cell lines. Functionally, overexpression of ciRS-7 promotes ESCC cell migration and invasion, with little effect on proliferation in the tested KYSE150 and Eca9706 cells. Mechanistically, ciRS-7 acts through the miR-7/KLF4 axis and activates NF-kappaB p65 signaling via IKK-alpha phosphorylation, suggesting ciRS-7 as a potential therapeutic target for ESCC."	0.5732
30207869	Cancer biology & therapy	2018	Emerging roles of circRNA_NEK6 targeting miR-370-3p in the proliferation and invasion of thyroid cancer via Wnt signaling pathway.	hsa_circ_0088483	circRNA_NEK6 / circNEK6	hsa_circ_NEK6	NEK6	thyroid cancer / TC	MONDO:0002108	thyroid cancer	up-regulated	RT-qPCR; Microarray	"circNEK6 (hsa_circ_0088483) is up-regulated in thyroid cancer tissues and cell lines. It promotes thyroid cancer cell proliferation and invasion while suppressing apoptosis by sponging miR-370-3p, increasing FZD8 expression, and activating the Wnt signaling pathway."	0.7785
30212824	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	"The CircRNA-ACAP2/Hsa-miR-21-5p/ Tiam1 Regulatory Feedback Circuit Affects the Proliferation, Migration, and Invasion of Colon Cancer SW480 Cells."	hsa_circ_0007331	circRNA-ACAP2	hsa_circ_ACAP2	ACAP2	colon cancer	MONDO:0021063	malignant colon neoplasm	up-regulated	RT-qPCR	"circRNA-ACAP2 is up-regulated in colon cancer and promotes SW480 cell proliferation, migration, invasion, clonogenicity, and in vivo tumor growth. Mechanistically, it acts as a miRNA sponge for hsa-miR-21-5p, thereby relieving repression of Tiam1 in a ceRNA axis."	0.5925
30214545	Experimental and therapeutic medicine	2018	Hsa_circ_0033155: A potential novel biomarker for non-small cell lung cancer.	hsa_circ_0033155				non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"hsa_circ_0033155 is significantly downregulated in NSCLC tissues and cell lines, and its aberrant expression is associated with lymphatic metastasis. Functional overexpression experiments indicate that hsa_circ_0033155 suppresses NSCLC cell proliferation, colony formation and migration, while increasing PTEN mRNA and protein levels. The study proposes hsa_circ_0033155 as a potential diagnostic biomarker and therapeutic target for NSCLC."	0.5414
30215537	Epigenomics	2018	Circular RNA hsa_circ_0000993 inhibits metastasis of gastric cancer cells.	hsa_circ_0000993	hsa circ 0000993	hsa_circ_ATL2	ATL2	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0000993 is a human circRNA derived from ATL2 and is reduced in the highly aggressive gastric cancer cell line BGC-823 compared with SGC-7901. Its overexpression suppresses gastric cancer cell migration, invasion and proliferation, likely by competitively binding miR-214-5p rather than by regulating ATL2 or miR-214-5p expression levels."	0.7519
30219508	International journal of biological macromolecules	2019	Upregulated circular RNA circ-102004 that promotes cell proliferation in prostate cancer.		circ-102004	hsa_circ_USP22	USP22	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circ-102004 is upregulated in prostate cancer tissues and acts as an oncogenic circRNA. Its overexpression promotes PCa cell proliferation, migration, invasion and xenograft tumor growth while suppressing apoptosis, likely through activation of multiple cancer-related signaling pathways including ERK, JNK, Hedgehog and Wnt/beta-catenin. The study proposes circ-102004 as a potential diagnostic biomarker and therapeutic target for PCa."	0.73
30219673	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2018	"Novel circular RNA, hsa_circ_0025039 promotes cell growth, invasion and glucose metabolism in malignant melanoma via the miR-198/CDK4 axis."	hsa_circ_0025039	circ_0025039	hsa_circ_FOXM1	FOXM1	melanoma	MONDO:0005105	melanoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0025039 is up-regulated in melanoma tissues and cell lines, and high expression is associated with worse survival. Functionally, it promotes melanoma cell growth, invasion, glucose metabolism and xenograft tumor formation by sponging miR-198 and regulating CDK4 expression."	0.8709
30219673	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2018	"Novel circular RNA, hsa_circ_0025039 promotes cell growth, invasion and glucose metabolism in malignant melanoma via the miR-198/CDK4 axis."	hsa_circ_0062270				melanoma	MONDO:0005105	melanoma	dysregulated	RT-qPCR; Microarray	"hsa_circ_0062270 was one of six circRNAs differentially expressed in malignant melanoma tissues and validated by qRT-PCR, but the study did not further investigate its mechanism or clinical significance."	0.4773
30219673	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2018	"Novel circular RNA, hsa_circ_0025039 promotes cell growth, invasion and glucose metabolism in malignant melanoma via the miR-198/CDK4 axis."	hsa_circ_0079593				melanoma	MONDO:0005105	melanoma	dysregulated	RT-qPCR; Microarray	"hsa_circ_0079593 was one of six circRNAs differentially expressed in malignant melanoma tissues and validated by qRT-PCR, but the study did not further investigate its mechanism or clinical significance."	0.4773
30219673	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2018	"Novel circular RNA, hsa_circ_0025039 promotes cell growth, invasion and glucose metabolism in malignant melanoma via the miR-198/CDK4 axis."	hsa_circ_0009543				melanoma	MONDO:0005105	melanoma	dysregulated	RT-qPCR; Microarray	"hsa_circ_0009543 was one of six circRNAs differentially expressed in malignant melanoma tissues and validated by qRT-PCR, but the study did not further investigate its mechanism or clinical significance."	0.4773
30219673	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2018	"Novel circular RNA, hsa_circ_0025039 promotes cell growth, invasion and glucose metabolism in malignant melanoma via the miR-198/CDK4 axis."	hsa_circ_0009547				melanoma	MONDO:0005105	melanoma	dysregulated	RT-qPCR; Microarray	"hsa_circ_0009547 was one of six circRNAs differentially expressed in malignant melanoma tissues and validated by qRT-PCR, but the study did not further investigate its mechanism or clinical significance."	0.4773
30219673	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2018	"Novel circular RNA, hsa_circ_0025039 promotes cell growth, invasion and glucose metabolism in malignant melanoma via the miR-198/CDK4 axis."	hsa_circ_0023114				melanoma	MONDO:0005105	melanoma	dysregulated	RT-qPCR; Microarray	"hsa_circ_0023114 was one of six circRNAs differentially expressed in malignant melanoma tissues and validated by qRT-PCR, but the study did not further investigate its mechanism or clinical significance."	0.4773
30224298	"Blood cells, molecules & diseases"	2018	CircBA9.3 supports the survival of leukaemic cells by up-regulating c-ABL1 or BCR-ABL1 protein levels.		circBA9.3	hsa_circ_BCR-ABL1	BCR-ABL1	chronic myeloid leukemia / CML	MONDO:0011996	"chronic myelogenous leukemia, BCR-ABL1 positive"	up-regulated	RT-qPCR	"CircBA9.3 is a novel fusion circRNA derived from the BCR-ABL1 oncogene and is overexpressed in some TKI-resistant CML patients. It promotes leukaemic cell proliferation, suppresses TKI-induced apoptosis, and enhances c-ABL1/BCR-ABL1 protein expression, thereby contributing to TKI resistance and representing a potential diagnostic or therapeutic target."	0.7046
30237316	"Clinical science (London, England : 1979)"	2018	"The down-regulation of hsa_circ_0012919, the sponge for miR-125a-3p, contributes to DNA methylation of CD11a and CD70 in CD4+ T cells of systemic lupus erythematous."	hsa_circ_0012919				systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	up-regulated	RT-qPCR; Microarray	"hsa_circ_0012919 is up-regulated in CD4+ T cells from SLE patients and correlates with disease-related clinical features, supporting its potential as a biomarker. Mechanistically, it functions as a ceRNA for miR-125a-3p, regulates KLF13/RANTES, and is linked to DNMT1-dependent DNA methylation changes of CD11a and CD70."	0.659
30237316	"Clinical science (London, England : 1979)"	2018	"The down-regulation of hsa_circ_0012919, the sponge for miR-125a-3p, contributes to DNA methylation of CD11a and CD70 in CD4+ T cells of systemic lupus erythematous."	hsa_circ_0006239				systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	up-regulated	RT-qPCR; Microarray	hsa_circ_0006239 is up-regulated in CD4+ T cells from SLE patients and shows higher expression in active SLE than inactive SLE and healthy controls. The study did not report a mechanistic function or molecular interaction for this circRNA.	0.3588
30237316	"Clinical science (London, England : 1979)"	2018	"The down-regulation of hsa_circ_0012919, the sponge for miR-125a-3p, contributes to DNA methylation of CD11a and CD70 in CD4+ T cells of systemic lupus erythematous."	hsa_circ_0002227				systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	up-regulated	RT-qPCR; Microarray	"hsa_circ_0002227 is up-regulated in CD4+ T cells from SLE patients compared with healthy controls. Unlike hsa_circ_0012919 and hsa_circ_0006239, its expression did not significantly differ between inactive and active SLE patients, and no mechanism was investigated."	0.3588
30241943	Biochemical and biophysical research communications	2018	Circ-SATB2 upregulates STIM1 expression and regulates vascular smooth muscle cell proliferation and differentiation through miR-939.	hsa_circ_0007422	circ-SATB2	hsa_circ_SATB2	SATB2	coronary heart disease / CHD	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR	"In this study, hsa_circ_0007422/circ-SATB2 was up-regulated in proliferative VSMCs. It functions as a miR-939 sponge to upregulate STIM1, thereby promoting VSMC proliferation and migration, inhibiting apoptosis, and regulating phenotypic differentiation. The authors suggest circ-SATB2 may be relevant to the pathogenesis and potential diagnosis or treatment of cardiovascular diseases such as CHD."	0.5607
30243714	Biochemical and biophysical research communications	2018	The circular RNA circ-ITCH suppresses ovarian carcinoma progression through targeting miR-145/RASA1 signaling.		circ-ITCH	hsa_circ_ITCH	ITCH	ovarian cancer / OC	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR	"circ-ITCH is down-regulated in ovarian cancer tissues and cells, and low expression is associated with poor prognosis. Functionally, circ-ITCH overexpression suppresses OC cell proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, circ-ITCH acts as a cytoplasmic ceRNA that sponges miR-145 to increase RASA1 expression, forming the circ-ITCH-miR-145-RASA1 tumor-suppressive axis."	0.817
30249393	Biochemical and biophysical research communications	2018	Hsa_circRNA_103809 regulated the cell proliferation and migration in colorectal cancer via miR-532-3p / FOXO4 axis.	hsa_circ_0072088	circZFR / hsa_circRNA_103809	hsa_circ_ZFR	ZFR	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"hsa_circRNA_103809/hsa_circ_0072088 is down-regulated in colorectal cancer tissues and cell lines and is associated with clinical stage and lymph node metastasis. Functionally, loss of hsa_circRNA_103809 promotes CRC cell proliferation and migration, while mechanistically it may act as a ceRNA for miR-532e3p to regulate FOXO4 expression. The study suggests hsa_circRNA_103809 is a tumor-suppressive circRNA and a potential biomarker or therapeutic target in CRC."	0.5761
30252576	Cancer biology & therapy	2018	Circ0043898 acts as a tumor inhibitor and performs regulatory effect on the inhibition of esophageal carcinoma.		circ0043898			esophageal carcinoma	MONDO:0019086	carcinoma of esophagus	down-regulated	RT-qPCR; RNA-seq	"circ0043898 is down-regulated in esophageal carcinoma tissues and functions as a tumor suppressor. Its overexpression inhibits proliferation, migration, invasion and tumor growth, promotes apoptosis, and may act through transcriptomic regulation involving Histone H3, BMI1 and potentially the Wnt pathway. The study proposes circ0043898 as a potential diagnostic and therapeutic biomarker for esophageal carcinoma."	0.761
30257349	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2018	Circular RNA hsa_circ_0052112 promotes cell migration and invasion by acting as sponge for miR-125a-5p in breast cancer.	hsa_circ_0052112	circ-0052112	hsa_circ_ZNF83	ZNF83	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0052112 is a ZNF83-derived circRNA upregulated in the highly invasive breast cancer cell line MDA-MB-231 compared with MCF-7. It promotes breast cancer cell migration and invasion by sponging miR-125a-5p, and may also increase ZNF83 expression. The authors propose hsa_circ_0052112 as a potential biomarker and therapeutic target for breast cancer."	0.7006
30257390	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2018	Differentially expressed circular RNAs in systemic lupus erythematosus and their clinical significance.		hsa_circRNA_407176			systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_407176 was down-regulated in plasma and PBMCs from SLE patients and showed diagnostic value, especially in PBMCs. The study also predicted a ceRNA-related mechanism, but did not experimentally validate specific miRNA or mRNA interactions."	0.6556
30257390	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2018	Differentially expressed circular RNAs in systemic lupus erythematosus and their clinical significance.		hsa_circRNA_001308			systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_001308 was down-regulated in plasma and PBMCs from SLE patients and had diagnostic value in ROC analyses. Its expression was associated with CRP, anti-SSA antibody status, and leukopenia, suggesting potential relevance to systemic inflammation or disease severity; predicted ceRNA interactions were explored bioinformatically."	0.6556
30257390	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2018	Differentially expressed circular RNAs in systemic lupus erythematosus and their clinical significance.		hsa_circRNA_406567			systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_406567 was significantly lower in PBMCs from SLE patients and showed diagnostic value in PBMC ROC analysis, although it was not significantly changed in plasma validation. The authors also reported correlation with anti-RNP in plasma and predicted ceRNA relationships bioinformatically."	0.6556
30259280	Digestive diseases and sciences	2019	CircScd1 Promotes Fatty Liver Disease via the Janus Kinase 2/Signal Transducer and Activator of Transcription 5 Pathway.		circScd1 / circ-Scd1	mmu_circ_Scd1	Scd1	Nonalcoholic fatty liver disease / NAFLD	MONDO:0013209	metabolic dysfunction-associated steatotic liver disease	down-regulated	RT-qPCR; Microarray	"circScd1 is down-regulated in liver tissues from HFD-fed NAFLD mice. Functional experiments in AML-12 cells showed that circScd1 overexpression reduces steatosis and triglyceride accumulation, while circScd1 knockdown increases lipid droplet formation. Mechanistically, circScd1 positively regulates JAK2 and STAT5 protein expression and affects NAFLD steatosis through the JAK2/STAT5 pathway."	0.4636
30261810	Journal of neurotrauma	2019	Circular Ribonucleic Acid Expression Profile in Mouse Cortex after Traumatic Brain Injury.		circRNA_16895			Traumatic brain injury / TBI	MONDO:0858950	traumatic brain injury	dysregulated	RNA-seq	"circRNA_16895 was identified as a core dysregulated circRNA in mouse cortex after TBI. Bioinformatic analyses predicted that it may act through a ceRNA mechanism involving miRNA X_40676, 6_32269, mmu-miR-214-3p and Myo10-004 to regulate Fc gamma R-mediated phagocytosis and brain immune responses."	0.31
30261810	Journal of neurotrauma	2019	Circular Ribonucleic Acid Expression Profile in Mouse Cortex after Traumatic Brain Injury.		circRNA_01564			Traumatic brain injury / TBI	MONDO:0858950	traumatic brain injury	dysregulated	RNA-seq	"circRNA_01564 was identified as a central circRNA in the predicted circRNA-mRNA crosstalk network after TBI. It was predicted to act as a ceRNA, including potential regulation of Ttn-202 through shared miRNAs such as miR-200a."	0.31
30261810	Journal of neurotrauma	2019	Circular Ribonucleic Acid Expression Profile in Mouse Cortex after Traumatic Brain Injury.		circRNA_11926			Traumatic brain injury / TBI	MONDO:0858950	traumatic brain injury	dysregulated	RNA-seq	"circRNA_11926 was identified as a central circRNA in the predicted circRNA-mRNA crosstalk network after TBI. The study predicted that circRNA_11926 may regulate Hmcn1-001 and Pou6f2-001 through shared miRNAs, linking it to neuronal development and neuroinflammation-related processes."	0.31
30261810	Journal of neurotrauma	2019	Circular Ribonucleic Acid Expression Profile in Mouse Cortex after Traumatic Brain Injury.		circRNA_03981			Traumatic brain injury / TBI	MONDO:0858950	traumatic brain injury	up-regulated	RT-qPCR; RNA-seq	circRNA_03981 was identified by RNA-seq as differentially expressed in mouse cortex after TBI and validated by qRT-PCR. It was up-regulated in CCI brain tissue compared with craniotomy-only control brain samples.	0.3213
30261810	Journal of neurotrauma	2019	Circular Ribonucleic Acid Expression Profile in Mouse Cortex after Traumatic Brain Injury.		circRNA_04794			Traumatic brain injury / TBI	MONDO:0858950	traumatic brain injury	up-regulated	RT-qPCR; RNA-seq	circRNA_04794 was identified by RNA-seq as differentially expressed in mouse cortex after TBI and validated by qRT-PCR. It was up-regulated in CCI brain tissue compared with craniotomy-only control brain samples.	0.3213
30261810	Journal of neurotrauma	2019	Circular Ribonucleic Acid Expression Profile in Mouse Cortex after Traumatic Brain Injury.		circRNA_17877			Traumatic brain injury / TBI	MONDO:0858950	traumatic brain injury	down-regulated	RT-qPCR; RNA-seq	circRNA_17877 was identified by RNA-seq as differentially expressed in mouse cortex after TBI and validated by qRT-PCR. It was down-regulated in CCI brain tissue compared with craniotomy-only control brain samples.	0.3213
30261810	Journal of neurotrauma	2019	Circular Ribonucleic Acid Expression Profile in Mouse Cortex after Traumatic Brain Injury.		circRNA_02128			Traumatic brain injury / TBI	MONDO:0858950	traumatic brain injury	down-regulated	RT-qPCR; RNA-seq	circRNA_02128 was identified by RNA-seq as differentially expressed in mouse cortex after TBI and validated by qRT-PCR. It was down-regulated in CCI brain tissue compared with craniotomy-only control brain samples.	0.3213
30265210	"Cell cycle (Georgetown, Tex.)"	2018	Circular RNA 101368/miR-200a axis modulates the migration of hepatocellular carcinoma through HMGB1/RAGE signaling.		circRNA-101368			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circRNA 101368 is upregulated in HCC tissues and cell lines and high expression is associated with poor prognosis. Functionally, circRNA 101368 promotes HCC cell migration by binding miR-200a and modulating the HMGB1/RAGE signaling axis, with effects on HMGB1, RAGE, NF-kappaB, and E-Cadherin."	0.7878
30278433	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	Circular RNA Expression Profile and Analysis of Their Potential Function in Psoriasis.	hsa_circ_0061012				psoriasis	MONDO:0005083	psoriasis	up-regulated	RT-qPCR; Microarray	"This study found that hsa_circ_0061012 is significantly up-regulated in psoriatic lesions and may serve as a candidate biomarker for psoriasis. Bioinformatic analyses suggested that hsa_circ_0061012 may function through a ceRNA-related mechanism involving five predicted miRNAs and psoriasis-related target processes such as T cell selection, response to interleukin 4, and regulation of NF-kappaB import into nucleus."	0.4032
30282067	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	Circular RNA Expression Profile in Laryngeal Squamous Cell Carcinoma Revealed by Microarray.	hsa_circ_0044520		hsa_circ_COL1A1	COL1A1	laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circ_0044520 is up-regulated in LSCC tissues and was validated by qRT-PCR in both the test and independent validation cohorts. The study proposes that it may contribute to LSCC pathogenesis through a ceRNA-like miRNA sponge mechanism involving hsa-miR-4726-5p and collagen synthesis-related COL1A1-derived circRNA biology.	0.5135
30282067	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	Circular RNA Expression Profile in Laryngeal Squamous Cell Carcinoma Revealed by Microarray.	hsa_circ_0044529		hsa_circ_COL1A1	COL1A1	laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circ_0044529 is up-regulated in LSCC tissues and was validated by qRT-PCR in both the test and independent validation cohorts. The study proposes that it may contribute to LSCC pathogenesis through a ceRNA-like miRNA sponge mechanism involving hsa-miR-4640-5p and collagen synthesis-related COL1A1-derived circRNA biology.	0.5135
30286957	Biochemical and biophysical research communications	2018	Intrathecal circHIPK3 shRNA alleviates neuropathic pain in diabetic rats.		circHIPK3	hsa_circ_HIPK3	HIPK3	type 2 diabetes	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in serum from patients with type 2 diabetes and neuropathic pain and in dorsal root ganglion from STZ-induced diabetic rats. The study shows that circHIPK3 promotes diabetic neuropathic pain and neuroinflammation by interacting with and negatively regulating miR-124, while intrathecal circHIPK3 shRNA alleviates pain behaviors and inflammatory cytokine expression. Clinically, higher serum circHIPK3 is associated with greater neuropathic pain severity and may serve as a biomarker or predictive factor."	0.6672
30286957	Biochemical and biophysical research communications	2018	Intrathecal circHIPK3 shRNA alleviates neuropathic pain in diabetic rats.		circHIPK3	rno_circ_HIPK3	HIPK3	type 2 diabetes	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in serum from patients with type 2 diabetes and neuropathic pain and in dorsal root ganglion from STZ-induced diabetic rats. The study shows that circHIPK3 promotes diabetic neuropathic pain and neuroinflammation by interacting with and negatively regulating miR-124, while intrathecal circHIPK3 shRNA alleviates pain behaviors and inflammatory cytokine expression. Clinically, higher serum circHIPK3 is associated with greater neuropathic pain severity and may serve as a biomarker or predictive factor."	0.6672
30302825	Immunology and cell biology	2019	Hsa_circ_101280 promotes hepatocellular carcinoma by regulating miR-375/JAK2.	hsa_circ_0100929	hsa_circ_101280	hsa_circ_SLAIN1	SLAIN1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_101280 is up-regulated in HCC tissues and cell lines and acts as an oncogenic circRNA. It promotes HCC cell proliferation and xenograft tumor growth while suppressing apoptosis, mainly by sponging miR-375 and increasing JAK2 expression. The study suggests hsa_circ_101280 may serve as a biomarker and therapeutic target for HCC."	0.7785
30304349	Journal of biochemistry	2019	CircRNA_001569 promotes cell proliferation through absorbing miR-145 in gastric cancer.		circRNA_001569 / hsa_circ_001569			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circRNA_001569 is up-regulated in gastric cancer tissues and cell lines. It promotes gastric cancer cell proliferation/viability and inhibits apoptosis by acting as a ceRNA that absorbs miR-145, leading to regulation of NR4A2. Its expression is associated with tumor size, clinical stage and depth of invasion."	0.6831
30305293	Clinical cancer research : an official journal of the American Association for Cancer Research	2018	PRMT5 Circular RNA Promotes Metastasis of Urothelial Carcinoma of the Bladder through Sponging miR-30c to Induce Epithelial-Mesenchymal Transition.		circRNA_101320 / circPRMT5	hsa_circ_PRMT5	PRMT5	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"circPRMT5 is a PRMT5-derived human circRNA that is frequently upregulated in UCB tissues and in serum/urine exosomes from patients with UCB. It promotes EMT, migration, invasion and lung metastasis by sponging miR-30c and relieving miR-30c-mediated repression of the SNAIL1/E-cadherin pathway. Clinically, high circPRMT5 expression is associated with advanced disease, lymph node metastasis and poorer survival, supporting its value as a prognostic biomarker and potential therapeutic target."	0.8988
30307766	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2019	"circDiaph3 regulates rat vascular smooth muscle cell differentiation, proliferation, and migration."		rno-circ_005717 / circDiaph3	rno_circ_Diaph3		vascular restenosis	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR; Microarray	"circDiaph3 is up-regulated in balloon-injured rat carotid arteries with intimal hyperplasia. It promotes VSMC dedifferentiation, proliferation, and migration partly by reducing Diaph3 protein and by acting as a ceRNA for miR-148a-5p to relieve inhibition of Igf1r and activate IGF-1 signaling. Knockdown of circDiaph3 reverses these disease-associated VSMC changes, suggesting a potential therapeutic target for intimal hyperplasia."	0.765
30314706	Biochemical and biophysical research communications	2018	Upregulation of circ-UBAP2 predicts poor prognosis and promotes triple-negative breast cancer progression through the miR-661/MTA1 pathway.	hsa_circ_0001846	circ-UBAP2	hsa_circ_UBAP2	UBAP2	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; Microarray	"circ-UBAP2 is upregulated in TNBC tissues and cell lines and high expression predicts poor overall survival. Functionally, circ-UBAP2 promotes TNBC proliferation, migration, tumour growth and metastasis while suppressing apoptosis. Mechanistically, it mainly localizes in the cytoplasm and acts through the miR-661/MTA1 ceRNA axis."	0.8192
30317540	Journal of cellular physiology	2019	The competing endogenous circular RNA ADAMTS14 suppressed hepatocellular carcinoma progression through regulating microRNA-572/regulator of calcineurin 1.	hsa_circ_0018665	circular RNA ADAMTS14 / circADAMTS14	hsa_circ_ADAMTS14	ADAMTS14	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"circADAMTS14 is down-regulated in HCC tissues and cell lines. It suppresses HCC progression by acting as a competing endogenous RNA that sponges miR-572 and increases RCAN1 expression, thereby inhibiting proliferation, migration, invasion, and xenograft tumor growth while promoting apoptosis."	0.7799
30320923	Journal of cellular biochemistry	2019	Analysis of differentially expressed circular RNAs for the identification of a coexpression RNA network and signature in colorectal cancer.	hsa_circ_0000826	cir-cRNA.1213 / circ_0000826			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000826 was identified by RNA sequencing and validated by RT-qPCR as significantly downregulated in CRC tissues and most CRC cell lines. Its expression was associated with tumor size, TNM stage, lymph metastasis, and distant metastasis, suggesting potential diagnostic or clinicopathological relevance in CRC."	0.4032
30320923	Journal of cellular biochemistry	2019	Analysis of differentially expressed circular RNAs for the identification of a coexpression RNA network and signature in colorectal cancer.	hsa_circ_0009022				colorectal cancer / CRC	MONDO:0005575	colorectal cancer	dysregulated	RNA-seq	"hsa_circ_0009022 was identified as a hub circRNA in CRC based on RNA-seq-derived coexpression networks. It showed high correlation with coexpressed mRNAs and predicted high miRNA-binding affinity, suggesting a possible regulatory role in CRC gene expression."	0.1768
30320923	Journal of cellular biochemistry	2019	Analysis of differentially expressed circular RNAs for the identification of a coexpression RNA network and signature in colorectal cancer.	hsa_circ_0006867				colorectal cancer / CRC	MONDO:0005575	colorectal cancer	dysregulated	RNA-seq	hsa_circ_0006867 was one of the hub differentially expressed circRNAs identified from the CRC RNA-seq coexpression network. Its high degree and strong coexpression correlation with mRNAs suggest a possible role in regulating CRC-related gene expression.	0.1768
30320923	Journal of cellular biochemistry	2019	Analysis of differentially expressed circular RNAs for the identification of a coexpression RNA network and signature in colorectal cancer.	hsa_circ_0001614				colorectal cancer / CRC	MONDO:0005575	colorectal cancer	dysregulated	RNA-seq	hsa_circ_0001614 was one of the hub differentially expressed circRNAs identified from the CRC RNA-seq coexpression network. Its high degree and strong coexpression correlation with mRNAs suggest a possible role in regulating CRC-related gene expression.	0.1768
30320923	Journal of cellular biochemistry	2019	Analysis of differentially expressed circular RNAs for the identification of a coexpression RNA network and signature in colorectal cancer.		circRNA.196			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	dysregulated	RNA-seq	circRNA.196 was an unknown circRNA identified as a hub differentially expressed circRNA in the CRC RNA-seq coexpression network. Its high network degree and strong coexpression with mRNAs suggest a possible role in regulating differential gene expression in CRC.	0.1768
30341421	Cell death and differentiation	2019	Circular RNA circAGO2 drives cancer progression through facilitating HuR-repressed functions of AGO2-miRNA complexes.	hsa_circ_0135889	circRNA generated from AGO2 / circAGO2	hsa_circ_AGO2	AGO2	gastric cancer	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Northern Blot	"CircAGO2 is a human AGO2-derived intronic circRNA that is up-regulated in gastric cancer, colon cancer, prostate cancer, and neuroblastoma. It functions as an oncogenic circRNA by binding and activating HuR, thereby reducing AGO2/miRNA-mediated gene silencing of cancer progression-related target genes and promoting tumor growth, invasion, metastasis, and poor prognosis."	0.898
30341421	Cell death and differentiation	2019	Circular RNA circAGO2 drives cancer progression through facilitating HuR-repressed functions of AGO2-miRNA complexes.	hsa_circ_0135889	circRNA generated from AGO2 / circAGO2	hsa_circ_AGO2	AGO2	colon cancer	MONDO:0021063	malignant colon neoplasm	up-regulated	RT-qPCR; Northern Blot	"CircAGO2 is a human AGO2-derived intronic circRNA that is up-regulated in gastric cancer, colon cancer, prostate cancer, and neuroblastoma. It functions as an oncogenic circRNA by binding and activating HuR, thereby reducing AGO2/miRNA-mediated gene silencing of cancer progression-related target genes and promoting tumor growth, invasion, metastasis, and poor prognosis."	0.898
30341421	Cell death and differentiation	2019	Circular RNA circAGO2 drives cancer progression through facilitating HuR-repressed functions of AGO2-miRNA complexes.	hsa_circ_0135889	circRNA generated from AGO2 / circAGO2	hsa_circ_AGO2	AGO2	prostate cancer	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Northern Blot	"CircAGO2 is a human AGO2-derived intronic circRNA that is up-regulated in gastric cancer, colon cancer, prostate cancer, and neuroblastoma. It functions as an oncogenic circRNA by binding and activating HuR, thereby reducing AGO2/miRNA-mediated gene silencing of cancer progression-related target genes and promoting tumor growth, invasion, metastasis, and poor prognosis."	0.898
30341421	Cell death and differentiation	2019	Circular RNA circAGO2 drives cancer progression through facilitating HuR-repressed functions of AGO2-miRNA complexes.	hsa_circ_0135889	circRNA generated from AGO2 / circAGO2	hsa_circ_AGO2	AGO2	neuroblastoma	MONDO:0005072	neuroblastoma	up-regulated	RT-qPCR; Northern Blot	"CircAGO2 is a human AGO2-derived intronic circRNA that is up-regulated in gastric cancer, colon cancer, prostate cancer, and neuroblastoma. It functions as an oncogenic circRNA by binding and activating HuR, thereby reducing AGO2/miRNA-mediated gene silencing of cancer progression-related target genes and promoting tumor growth, invasion, metastasis, and poor prognosis."	0.898
30341906	Journal of cellular physiology	2019	Circ-U2AF1 promotes human glioma via derepressing neuro-oncological ventral antigen 2 by sponging hsa-miR-7-5p.	hsa_circ_0061868	circ-U2AF1	hsa_circ_U2AF1	U2AF1	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ-U2AF1 (hsa_circ_0061868) is upregulated in human glioma tissues and glioma cell lines and its expression positively correlates with glioma grade. Functionally, circ-U2AF1 promotes glioma cell proliferation, migration, invasion, metastasis-like behavior and xenograft tumor growth, while suppressing apoptosis. Mechanistically, it sponges hsa-miR-7-5p to derepress NOVA2, forming a circ-U2AF1/hsa-miR-7-5p/NOVA2 regulatory pathway with potential prognostic and therapeutic relevance."	0.705
30342168	Gene	2019	CircRNA has_circ_0078710 acts as the sponge of microRNA-31 involved in hepatocellular carcinoma progression.	hsa_circ_0078710		hsa_circ_THBS2	THBS2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"has_circ_0078710 is up-regulated in HCC tissues and cell lines and is associated with advanced TNM stage. It promotes HCC proliferation, colony formation, cell-cycle progression, migration, invasion, and xenograft tumor growth. Mechanistically, it acts as a cytoplasmic miR-31 sponge to relieve repression of HDAC2 and CDK2, supporting its potential as an oncogenic biomarker in HCC."	0.8354
30347599	Cancer biomarkers : section A of Disease markers	2018	"Circ-ITCH correlates with small tumor size, decreased FIGO stage and prolonged overall survival, and it inhibits cells proliferation while promotes cells apoptosis in epithelial ovarian cancer."		Circ-ITCH / circular RNA itchy E3 ubiquitin protein ligase	hsa_circ_ITCH		epithelial ovarian cancer / EOC	MONDO:0005140	ovarian carcinoma	down-regulated	RT-qPCR	"Circ-ITCH is down-regulated in epithelial ovarian cancer tumor tissues and EOC cell lines. Higher Circ-ITCH expression is associated with smaller tumor size, lower FIGO stage and better overall survival, while functional assays show that Circ-ITCH suppresses cell proliferation and enhances apoptosis in EOC cells."	0.6419
30349076	Cell death and differentiation	2019	The circular RNA ACR attenuates myocardial ischemia/reperfusion injury by suppressing autophagy via modulation of the Pink1/ FAM65B pathway.		mmu_circRNA_006636 / autophagy-related circRNA			myocardial ischemia/reperfusion injury	MONDO:0005203	ischemia reperfusion injury	down-regulated	RT-qPCR; Microarray	"ACR is a mouse circRNA down-regulated in myocardial I/R injury and A/R-treated cardiomyocytes. Functionally, ACR suppresses cardiomyocyte autophagy, mitophagy and cell death, thereby reducing myocardial infarct size and improving cardiac injury outcomes. Mechanistically, ACR binds Dnmt3B to inhibit Pink1 promoter methylation, activates Pink1 expression, and promotes Pink1-dependent phosphorylation of FAM65B to repress autophagy."	0.7818
30352682	Biochemical and biophysical research communications	2018	Circular RNA HIPK3 exerts oncogenic properties through suppression of miR-124 in lung cancer.		circular RNA HIPK3 / circHIPK3	hsa_circ_HIPK3	HIPK3	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circHIPK3 is upregulated in human lung cancer cells and tissues. It promotes lung cancer cell survival and proliferation while suppressing apoptosis, likely by sponging miR-124 and derepressing miR-124 targets including SphK1, STAT3 and CDK4. The study suggests the circHIPK3-miR-124 axis as a potential therapeutic target in lung cancer."	0.5442
30355941	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	The Differentially Expressed Circular RNAs in the Substantia Nigra and Corpus Striatum of Nrf2-Knockout Mice.		mmu_circRNA_015216			oxidative stress	MONDO:0000001	disease	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_015216 was significantly down-regulated in the substantia nigra of Nrf2-knockout mice and validated by qRT-PCR. The study predicts that it may function through a ceRNA-like mechanism involving Nrf2-related miRNAs, especially mmu-miR-34a and mmu-miR-27a, and may contribute to Nrf2-mediated neuroprotection against oxidative stress."	0.4851
30355941	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	The Differentially Expressed Circular RNAs in the Substantia Nigra and Corpus Striatum of Nrf2-Knockout Mice.		mmu_circRNA_017077			oxidative stress	MONDO:0000001	disease	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_017077 was significantly down-regulated in the corpus striatum of Nrf2-knockout mice and validated by qRT-PCR. The study predicts that it may participate in AD-related and rheumatoid arthritis-related Nrf2 processes through ceRNA-like interactions, including a mmu_circRNA_017077-miRNA-Fas axis linked to Fas-induced apoptosis."	0.4851
30355941	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	The Differentially Expressed Circular RNAs in the Substantia Nigra and Corpus Striatum of Nrf2-Knockout Mice.		mmu_circRNA_34132			oxidative stress	MONDO:0000001	disease	up-regulated	RT-qPCR; Microarray	"mmu_circRNA_34132 was significantly up-regulated in both the substantia nigra and corpus striatum of Nrf2-knockout mice and validated by qRT-PCR. The study predicts that it may act through ceRNA-like networks, including a mmu_circRNA_34132-mmu-miR-29b-1-5p-Grin2b interaction in AD-related Nrf2 processes and additional shared-miRNA interactions relevant to rheumatoid arthritis, insulin secretion, cardiac muscle contraction, diabetes mellitus, and ROS defense."	0.4851
30362519	Journal of cellular physiology	2019	Circ_0058063 regulates CDK6 to promote bladder cancer progression by sponging miR-145-5p.	hsa_circ_0058063	circ_0058063			bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0058063 is up-regulated in bladder cancer tissues and acts as an oncogenic circRNA. It promotes proliferation, migration, cell-cycle progression, and xenograft tumor growth while inhibiting apoptosis by sponging miR-145-5p and regulating CDK6 expression. The study suggests circ_0058063 as a potential therapeutic target or biomarker for bladder cancer."	0.7981
30362562	Journal of cellular physiology	2019	Overexpressed circ_0067934 acts as an oncogene to facilitate cervical cancer progression via the miR-545/EIF3C axis.	hsa_circ_0067934	circ_0067934			cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ_0067934 is upregulated in cervical cancer tissues and cell lines and its high expression is associated with advanced FIGO stage, lymph node metastasis, and poor survival. Functionally, circ_0067934 promotes proliferation, colony formation, migration, invasion, EMT, and xenograft tumor growth. Mechanistically, it facilitates cervical cancer progression through the miR-545/EIF3C axis."	0.7548
30370521	Journal of cellular physiology	2019	Hsa_circ_0136666 promotes the proliferation and invasion of colorectal cancer through miR-136/SH2B1 axis.	hsa_circ_0136666	circ_0136666	hsa_circ_PRKDC	PRKDC	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq; Microarray	"hsa_circ_0136666 is up-regulated in colorectal cancer tissues and cell lines and high expression predicts poorer overall survival. Functionally, it acts as an oncogenic circRNA that promotes proliferation, migration, invasion, EMT-related changes, cell cycle progression, and xenograft tumor growth. Mechanistically, it sponges miR-136 to increase SH2B1 expression, forming the hsa_circ_0136666/miR-136/SH2B1 regulatory axis."	0.8354
30376358	Cancer biotherapy & radiopharmaceuticals	2019	Upregulation of Circular RNA VPS13C-has-circ-001567 Promotes Ovarian Cancer Cell Proliferation and Invasion.		hsa-circRNA-001567	hsa_circ_VPS13C	VPS13C	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"VPS13C-has-circ-001567 is up-regulated in ovarian cancer tissues and cell lines. Functional knockdown experiments indicate that it promotes proliferation, cell cycle progression, invasion, EMT-related marker changes, and xenograft tumorigenicity while suppressing apoptosis. Its overexpression is associated with advanced TNM stage and lymph node metastasis, suggesting potential clinical value as a prognostic marker or therapeutic target."	0.6221
30376358	Cancer biotherapy & radiopharmaceuticals	2019	Upregulation of Circular RNA VPS13C-has-circ-001567 Promotes Ovarian Cancer Cell Proliferation and Invasion.		hsa-circ-00718	hsa_circ_RAD50	RAD50	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"RAD50-has-circ-00718 was one of three circRNAs evaluated in ovarian cancer. The study reports that RAD50-has-circ-00718 expression is significantly higher in OC tumor tissues than in matched pericarcinous tissues by RT-PCR, but no circRNA-specific functional or mechanistic experiments were reported for it."	0.2995
30376358	Cancer biotherapy & radiopharmaceuticals	2019	Upregulation of Circular RNA VPS13C-has-circ-001567 Promotes Ovarian Cancer Cell Proliferation and Invasion.		hsa-circ-000013	hsa_circ_SPECC1	SPECC1	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"SPECC1-has-circ-000013 was evaluated as one of three circRNAs in ovarian cancer. The study reports significantly higher SPECC1-has-circ-000013 expression in OC tumor tissues than in matched pericarcinous tissues by RT-PCR, but it does not report circRNA-specific functional or mechanistic validation for this circRNA."	0.2995
30379383	Hepatology research : the official journal of the Japan Society of Hepatology	2019	Differential expression of circular RNAs in hepatic tissue in a model of liver fibrosis and functional analysis of their target genes.		mmu_circ_33594			liver fibrosis	MONDO:0005155	cirrhosis of liver	dysregulated	RT-qPCR; Microarray	"mmu_circ_33594 was identified as one of five RT-qPCR-validated differentially expressed circRNAs in hepatic tissue from a CCl4-induced mouse liver fibrosis model. It was also increased in a TGF-beta1-induced JS1 hepatic stellate cell activation model, suggesting association with fibrosis-related cellular activation."	0.5495
30379383	Hepatology research : the official journal of the Japan Society of Hepatology	2019	Differential expression of circular RNAs in hepatic tissue in a model of liver fibrosis and functional analysis of their target genes.		mmu_circ_35216			liver fibrosis	MONDO:0005155	cirrhosis of liver	dysregulated	RT-qPCR; Microarray	"mmu_circ_35216 was one of five RT-qPCR-validated differentially expressed circRNAs in fibrotic mouse liver tissue. It was increased in both activated JS1 stellate cells and LPS-stimulated RAW264.7 macrophage inflammatory cells, linking it to fibrosis-related stellate cell activation and inflammation models."	0.5495
30379383	Hepatology research : the official journal of the Japan Society of Hepatology	2019	Differential expression of circular RNAs in hepatic tissue in a model of liver fibrosis and functional analysis of their target genes.		circRNA_42398 / mmu_circ_42398			liver fibrosis	MONDO:0005155	cirrhosis of liver	dysregulated	RT-qPCR; Microarray	"circRNA_42398/mmu_circ_42398 was RT-qPCR-validated as differentially expressed in fibrotic mouse liver tissue. It was decreased in hepatic stellate cell activation, hepatocyte oxidative stress injury, and macrophage inflammatory models, suggesting involvement in multiple fibrosis-related cellular processes."	0.5495
30379383	Hepatology research : the official journal of the Japan Society of Hepatology	2019	Differential expression of circular RNAs in hepatic tissue in a model of liver fibrosis and functional analysis of their target genes.		mmu_circ_34116			liver fibrosis	MONDO:0005155	cirrhosis of liver	dysregulated	RT-qPCR; Microarray	"mmu_circ_34116 was RT-qPCR-validated as a differentially expressed circRNA in fibrotic mouse liver tissue and was decreased in JS1 HSC activation and RAW264.7 inflammatory models. Functional knockdown in JS1 cells increased alpha-SMA mRNA and protein, indicating that mmu_circ_34116 inhibits hepatic stellate cell activation and may participate in liver fibrosis progression, potentially through predicted miRNA-target gene mechanisms including BMP7."	0.593
30379383	Hepatology research : the official journal of the Japan Society of Hepatology	2019	Differential expression of circular RNAs in hepatic tissue in a model of liver fibrosis and functional analysis of their target genes.		mmu_circ_30981			liver fibrosis	MONDO:0005155	cirrhosis of liver	dysregulated	RT-qPCR; Microarray	"mmu_circ_30981 was RT-qPCR-validated as differentially expressed in fibrotic mouse liver tissue. It was decreased in an LPS-stimulated RAW264.7 macrophage inflammatory model, suggesting association with inflammatory processes relevant to liver fibrosis, although no direct functional experiment was performed for this circRNA."	0.5495
30382592	Journal of cellular biochemistry	2019	"Upregulated circular RNA circ_0007534 indicates an unfavorable prognosis in pancreatic ductal adenocarcinoma and regulates cell proliferation, apoptosis, and invasion by sponging miR-625 and miR-892b."	hsa_circ_0007534	circ_0007534			pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR	"circ_0007534 is upregulated in PDAC tissues and cell lines and is associated with advanced tumor stage, lymph node invasion, and poor overall survival. Functionally, it acts as an oncogenic circRNA that promotes proliferation, migration, invasion, and xenograft tumor growth while inhibiting apoptosis. Mechanistically, circ_0007534 sponges miR-625 and miR-892b and affects apoptosis-related Bcl-2/caspase-3 signaling and MMP-2-associated invasive behavior."	0.7528
30384377	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	The Landscape of Non-Coding RNA in an Adult Pig Model of Intrauterine Growth Restriction.		circRNA7964			Intrauterine growth restriction / IUGR	MONDO:0005030	fetal growth restriction	up-regulated	RT-qPCR; RNA-seq	"circRNA7964 is up-regulated in the liver of adult IUGR pigs. The study proposes that circRNA7964 acts as a ceRNA sponge for miR-214, thereby increasing ATF4 expression and potentially promoting hepatic gluconeogenesis associated with IUGR-related metabolic syndrome."	0.3684
30384377	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	The Landscape of Non-Coding RNA in an Adult Pig Model of Intrauterine Growth Restriction.		circRNA16347			Intrauterine growth restriction / IUGR	MONDO:0005030	fetal growth restriction	dysregulated	RT-qPCR; RNA-seq	"circRNA16347 is differentially expressed in adult IUGR pig liver. The study proposes a predicted TCF7-miR22-3P-circRNA16347 ceRNA network that is consistent with increased hepatic gluconeogenesis in IUGR pigs, suggesting a potential role in IUGR-related metabolic dysfunction."	0.3684
30388035	DNA and cell biology	2018	"Circular RNA hsa_circ_0074362 Promotes Glioma Cell Proliferation, Migration, and Invasion by Attenuating the Inhibition of miR-1236-3p on HOXB7 Expression."	hsa_circ_0074362				glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"hsa_circ_0074362 is up-regulated in glioma tissues and cell lines, and high expression is associated with advanced clinical severity and poor prognosis. Functionally, hsa_circ_0074362 promotes glioma cell proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, it sponges miR-1236-3p to relieve inhibition of HOXB7 expression, forming a hsa_circ_0074362/miR-1236-3p/HOXB7 regulatory axis in glioma progression."	0.7365
30395908	Experimental hematology	2019	CircPAN3 mediates drug resistance in acute myeloid leukemia through the miR-153-5p/miR-183-5p-XIAP axis.	hsa_circ_0100181	circPAN3	hsa_circ_PAN3	PAN3	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; Microarray	"CircPAN3 is up-regulated in ADM-resistant AML cells and in bone marrow samples from refractory/recurrent AML patients. It promotes drug resistance by modulating the miR-153-5p/miR-183-5p-XIAP axis, increasing XIAP protein expression and suppressing apoptotic caspase activation. The study suggests circPAN3 may help predict chemotherapy efficacy and may be a therapeutic target for reversing AML drug resistance."	0.6676
30396080	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2019	Upregulation of circular RNA circ_0001721 predicts unfavorable prognosis in osteosarcoma and facilitates cell progression via sponging miR-569 and miR-599.	hsa_circ_0001721	circ_0001721	hsa_circ_CDK14	CDK14	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ_0001721 is up-regulated in osteosarcoma tissues and cell lines and its high expression predicts unfavorable prognosis. Functionally, it promotes OS cell proliferation, colony formation, migration, invasion and xenograft tumor growth, while suppressing apoptosis. Mechanistically, circ_0001721 acts partly by sponging miR-569 and miR-599."	0.7524
30396163	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	Circular RNA Expression Profiling Identifies Prostate Cancer- Specific circRNAs in Prostate Cancer.	hsa_circ_0057558	circ_0057558			Prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	"circ_0057558 was up-regulated in prostate cancer cell lines and tissues and was validated by qRT-PCR. It may function as a diagnostic biomarker, and the study suggests a predicted circ_0057558/miR-6884-3p/target-gene ceRNA relationship potentially linked to lipid metabolism in prostate cancer."	0.5047
30396163	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	Circular RNA Expression Profiling Identifies Prostate Cancer- Specific circRNAs in Prostate Cancer.	hsa_circ_0062019	circ_0062019	hsa_circ_SLC19A1	SLC19A1	Prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	circ_0062019 was up-regulated in prostate cancer cell lines and tissues and was validated by qRT-PCR. The study proposes circ_0062019 as a diagnostic biomarker and suggests a predicted circ_0062019/miR-5008-5p/SLC19A1 axis that may influence prostate cancer progression through folate-related biology.	0.5047
30396163	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	Circular RNA Expression Profiling Identifies Prostate Cancer- Specific circRNAs in Prostate Cancer.	hsa_circ_0034467	circ_0034467			Prostate cancer / PCa	MONDO:0008315	prostate cancer	dysregulated	Microarray	"circ_0034467 was included in the prostate cancer differential circRNA regulatory network analysis. The study predicts that it may act through miR-6884-3p and a circ_0034467/miR-6721-5p/SLC19A1 regulatory pattern, but no qRT-PCR validation was reported for this circRNA."	0.1768
30396163	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	Circular RNA Expression Profiling Identifies Prostate Cancer- Specific circRNAs in Prostate Cancer.	hsa_circ_0060325	circ_0060325			Prostate cancer / PCa	MONDO:0008315	prostate cancer	dysregulated	Microarray	"circ_0060325 was included in the prostate cancer differential circRNA regulatory network analysis. The study predicts that it may act through a circ_0060325/miR-5008-5p/SLC19A1 ceRNA pattern, but no qRT-PCR validation was reported for this circRNA."	0.1768
30403769	Carcinogenesis	2019	circCTIC1 promotes the self-renewal of colon TICs through BPTF-dependent c-Myc expression.		hsa_circRNA_103809 / circCTIC1			colon cancer	MONDO:0021063	malignant colon neoplasm	up-regulated	RT-qPCR; ISH	"circCTIC1 is up-regulated in colon tumors and colon TICs and is associated with tumor severity and prognosis. Functionally, circCTIC1 promotes colon TIC self-renewal, proliferation, and tumor initiation. Mechanistically, circCTIC1 interacts with BPTF/NURF complex and recruits it to the c-Myc promoter, activating c-Myc transcription."	0.8156
30412280	International journal of cancer	2019	Exosomal circRNA derived from gastric tumor promotes white adipose browning by targeting the miR-133/PRDM16 pathway.	hsa_circ_0010522	ciRS-133			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"ciRS-133 is a human exosomal circRNA up-regulated in plasma exosomes and tumor tissues of GC patients. Gastric cancer cell-derived exosomal ciRS-133 is delivered into preadipocytes, where it sponges miR-133 and activates the PRDM16/UCP1 axis, promoting WAT browning, metabolic activation, and cancer cachexia."	0.8061
30415780	Biochemical and biophysical research communications	2018	CircNUP214 sponges miR-145 to promote the expression of ZEB2 in thyroid cancer cells.	hsa_circ_0089153	circNUP214	hsa_circ_NUP214	NUP214	papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"circNUP214 is upregulated in papillary thyroid cancer tissues and cell lines. It functions as an oncogenic cytoplasmic circRNA by sponging miR-145, thereby increasing ZEB2 mRNA and protein expression and promoting PTC cell proliferation, migration, invasion, and xenograft tumor growth. The study proposes the circNUP214/miR-145/ZEB2 axis as a potential therapeutic target in PTC."	0.8206
30417526	Journal of cellular physiology	2019	CircRNA circPDSS1 promotes the gastric cancer progression by sponging miR-186-5p and modulating NEK2.	hsa_circ_0093398	circPDSS1	hsa_circ_PDSS1	PDSS1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circPDSS1 is up-regulated in gastric cancer tissues and cell lines and its high expression is associated with worse overall survival. Functionally, circPDSS1 promotes GC cell proliferation and cell cycle progression while inhibiting apoptosis. Mechanistically, it acts as a miR-186-5p sponge to modulate NEK2 through the circPDSS1/miR-186-5p/NEK2 axis."	0.7357
30417652	Epigenomics	2019	Identification and integrated analysis of key differentially expressed circular RNAs in ER-positive subtype breast cancer.	hsa_circ_0072304				ER-positive breast cancer	MONDO:0006512	estrogen-receptor positive breast cancer	down-regulated	RT-qPCR; Microarray	hsa circ 0072304 was identified by circRNA microarray and validated by qRT-PCR as significantly downregulated in ER-positive breast cancer tissues compared with paired adjacent nontumor tissues. The study did not define a specific molecular mechanism or functional role for this circRNA.	0.4773
30417652	Epigenomics	2019	Identification and integrated analysis of key differentially expressed circular RNAs in ER-positive subtype breast cancer.	hsa_circ_0087378		hsa_circ_NTRK2	NTRK2	ER-positive breast cancer	MONDO:0006512	estrogen-receptor positive breast cancer	down-regulated	RT-qPCR; Microarray	"hsa circ 0087378 was identified and qRT-PCR-validated as downregulated in ER-positive breast cancer tissues and in most breast cancer cell lines. The authors proposed that it functions as a tumor-suppressive ceRNA by sequestering miR-1260b and thereby upregulating SFRP1, making it a potential candidate target in ER-positive breast cancer."	0.5135
30417652	Epigenomics	2019	Identification and integrated analysis of key differentially expressed circular RNAs in ER-positive subtype breast cancer.	hsa_circ_0087377				ER-positive breast cancer	MONDO:0006512	estrogen-receptor positive breast cancer	down-regulated	RT-qPCR; Microarray	hsa circ 0087377 was identified by circRNA microarray and validated by qRT-PCR as significantly downregulated in ER-positive breast cancer tissues compared with paired adjacent nontumor tissues. The study did not define a specific molecular mechanism or functional role for this circRNA.	0.4773
30417652	Epigenomics	2019	Identification and integrated analysis of key differentially expressed circular RNAs in ER-positive subtype breast cancer.		circ-Foxo3	hsa_circ_Foxo3	Foxo3	ER-positive breast cancer	MONDO:0006512	estrogen-receptor positive breast cancer	down-regulated	Microarray	circ-Foxo3 was reported by the authors as a tumor-related circRNA detected by their microarray data and downregulated in breast cancer samples. It was not validated by qRT-PCR in this paper and no study-specific mechanism was presented.	0.1155
30419346	Cancer letters	2019	"A novel circular RNA, circFAT1(e2), inhibits gastric cancer progression by targeting miR-548g in the cytoplasm and interacting with YBX1 in the nucleus."	hsa_circ_0001461	circFAT1	hsa_circ_FAT1	FAT1	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; ISH; Microarray	"circFAT1(e2), also identified as hsa_circ_0001461, is a FAT1-derived circular RNA that is downregulated in gastric cancer tissues and cell lines. It functions as a tumor suppressor by sponging miR-548g to upregulate RUNX1 in the cytoplasm and by directly interacting with YBX1 in the nucleus, thereby suppressing proliferation, migration, invasion and xenograft tumor growth. Higher circFAT1(e2) expression is associated with better prognosis in GC patients."	0.891
30424877	Biochemical and biophysical research communications	2018	Circular RNA-100290 promotes cell proliferation and inhibits apoptosis in acute myeloid leukemia cells via sponging miR-203.		hsa_circ_100290	hsa_circ_SLC30A7	SLC30A7	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; Microarray	"hsa_circ_100290 is up-regulated in AML bone marrow samples and AML cell lines. It promotes AML cell proliferation and cell cycle progression while inhibiting apoptosis, at least partly by sponging miR-203 and regulating Rab10 and apoptosis/cell-cycle related proteins."	0.7591
30426540	Journal of cellular biochemistry	2019	"circRNAs (hsa_circ_00156, hsa_circ _000224, and hsa_circ _000520) are novel potential biomarkers in hepatocellular carcinoma."		hsa_circ_00156	hsa_circ_B4GALT2	B4GALT2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"hsa_circ_00156 was selected by bioinformatics as part of a serum circRNA biomarker panel and was validated by RT-qPCR in clinical serum samples. It was down-regulated in HCC and showed diagnostic biomarker potential, with expression associated with cirrhosis and relapse-free survival patterns."	0.6023
30426540	Journal of cellular biochemistry	2019	"circRNAs (hsa_circ_00156, hsa_circ _000224, and hsa_circ _000520) are novel potential biomarkers in hepatocellular carcinoma."		hsa_circ _000224	hsa_circ_c17orf107	c17orf107	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"hsa_circ_000224 was selected as part of a bioinformatics-derived serum circRNA biomarker panel and validated by RT-qPCR. It was up-regulated in HCC serum, showed strong diagnostic performance compared with AFP, and its expression was associated with tumor size and relapse-free survival patterns."	0.6023
30426540	Journal of cellular biochemistry	2019	"circRNAs (hsa_circ_00156, hsa_circ _000224, and hsa_circ _000520) are novel potential biomarkers in hepatocellular carcinoma."		hsa_circ _000520	hsa_circ_VIM	VIM	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"hsa_circ_000520 was selected as part of a bioinformatics-derived serum circRNA biomarker panel and validated by RT-qPCR in clinical serum samples. It was down-regulated in HCC, showed strong diagnostic biomarker potential, and was associated with worse relapse-free survival when positive/high, including independent prognostic value in Cox analysis."	0.6023
30429198	Clinical cancer research : an official journal of the American Association for Cancer Research	2019	FLI1 Exonic Circular RNAs as a Novel Oncogenic Driver to Promote Tumor Metastasis in Small Cell Lung Cancer.		FECR1 / FLI1 exonic circular RNA	hsa_circ_FLI1	FLI1	small cell lung cancer / SCLC	MONDO:0008433	small cell lung carcinoma	up-regulated	RT-qPCR; ISH	"FECR1 is a human FLI1-derived exonic circRNA up-regulated in SCLC tissues and serum exosomes. It promotes SCLC migration/metastasis through the miR584-3p/ROCK1 pathway, and serum exo-FECR1 is associated with disease stage, remission duration and chemotherapy response."	0.84
30429198	Clinical cancer research : an official journal of the American Association for Cancer Research	2019	FLI1 Exonic Circular RNAs as a Novel Oncogenic Driver to Promote Tumor Metastasis in Small Cell Lung Cancer.		FECR2	hsa_circ_FLI1	FLI1	small cell lung cancer / SCLC	MONDO:0008433	small cell lung carcinoma	up-regulated	RT-qPCR; ISH	FECR2 is a human FLI1-derived exonic circRNA up-regulated in SCLC tissues and enriched in the cytoplasm. It promotes migration and metastasis of SCLC cells through the miR584-3p/ROCK1 pathway and is associated with lymph node metastasis in SCLC patients.	0.8072
30443988	Journal of cellular physiology	2019	Circular RNA CCDC66 targets DCX to regulate cell proliferation and migration by sponging miR-488-3p in Hirschsprung's disease.	hsa_circ_0001313	Circular RNA CCDC66	hsa_circ_CCDC66	CCDC66	Hirschsprung disease / HSCR	MONDO:0018309	Hirschsprung disease	down-regulated	RT-qPCR	"cir-CCDC66 is significantly downregulated in HSCR intestinal tissues. Functionally, cir-CCDC66 promotes proliferation and migration in 293T and SH-SY5Y cells, while its reduction inhibits these processes. Mechanistically, cytoplasmic cir-CCDC66 sponges miR-488-3p to positively regulate DCX expression, and it may have diagnostic value for HSCR."	0.8562
30444423	Epigenomics	2019	Circular RNA circRHOT1 is upregulated and promotes cell proliferation and invasion in pancreatic cancer.	hsa_circ_0005397	circ-RHOT1	hsa_circ_RHOT1	RHOT1	pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; ISH; Microarray	"circRHOT1 (hsa_circ_0005397), derived from RHOT1, is upregulated in pancreatic cancer tissues and cell lines and is mainly localized in the cytoplasm. Knockdown of circRHOT1 suppresses pancreatic cancer cell proliferation, colony formation, invasion and migration. The study suggests circRHOT1 may act as an oncogenic ceRNA by binding miR-26b/miR-125a/miR-330/miR-382 family miRNAs and regulating tumor-associated pathways such as MAPK, Wnt and Ras signaling."	0.7404
30453307	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	Circular RNA Hsa_Circ_0091579 Serves as a Diagnostic and Prognostic Marker for Hepatocellular Carcinoma.	hsa_circ_0091579		hsa_circ_GPC3	GPC3	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"hsa_circ_0091579 is up-regulated in HCC tumor tissues compared with adjacent non-tumor tissues. Its elevated expression shows diagnostic potential and is associated with worse overall survival, supporting its use as a prognostic biomarker in HCC."	0.5923
30453307	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	Circular RNA Hsa_Circ_0091579 Serves as a Diagnostic and Prognostic Marker for Hepatocellular Carcinoma.		hsa_circ_16245-1			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_16245-1 was identified by circRNA microarray and validated by qRT-PCR as up-regulated in HCC tumor tissues in the initial patient set. ROC analysis suggested potential diagnostic value, although it was not pursued as the main prognostic marker because it was not detected in some HCC samples in the validation group."	0.5047
30455306	Proceedings of the National Academy of Sciences of the United States of America	2018	Discovery of Kaposi's sarcoma herpesvirus-encoded circular RNAs and a human antiviral circular RNA.	hsa_circ_0001400	circ_0001400	hsa_circ_RELL1	RELL1	KSHV infection / Kaposi's sarcoma herpesvirus infection	MONDO:0005055	Kaposi's sarcoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"hsa_circ_0001400 is a human circRNA induced by KSHV infection. It suppresses KSHV LANA and RTA expression and acts as an antiviral factor, potentially through viral miRNA binding and stimulation of host defense pathways."	0.5971
30455306	Proceedings of the National Academy of Sciences of the United States of America	2018	Discovery of Kaposi's sarcoma herpesvirus-encoded circular RNAs and a human antiviral circular RNA.	hsa_circ_0001741				KSHV infection / Kaposi's sarcoma herpesvirus infection	MONDO:0005055	Kaposi's sarcoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"hsa_circ_0001741 was identified as a human circRNA induced by KSHV infection and validated by divergent-primer RT-qPCR, but no specific downstream mechanism or functional phenotype was reported for it."	0.4835
30455306	Proceedings of the National Academy of Sciences of the United States of America	2018	Discovery of Kaposi's sarcoma herpesvirus-encoded circular RNAs and a human antiviral circular RNA.	hsa_circ_0008311				KSHV infection / Kaposi's sarcoma herpesvirus infection	MONDO:0005055	Kaposi's sarcoma	up-regulated	RT-qPCR; RNA-seq; Microarray	hsa_circ_0008311 was selected as a human circRNA responsive to KSHV infection and carrying predicted KSHV miRNA seed-matching sites. The paper did not report a specific functional phenotype for this circRNA.	0.5193
30455306	Proceedings of the National Academy of Sciences of the United States of America	2018	Discovery of Kaposi's sarcoma herpesvirus-encoded circular RNAs and a human antiviral circular RNA.	hsa_circ_0005145				KSHV infection / Kaposi's sarcoma herpesvirus infection	MONDO:0005055	Kaposi's sarcoma	up-regulated	RT-qPCR; RNA-seq; Microarray	hsa_circ_0005145 was selected as a human circRNA responsive to KSHV infection and carrying predicted KSHV miRNA seed-matching sites. The paper did not report a specific functional phenotype for this circRNA.	0.5193
30455306	Proceedings of the National Academy of Sciences of the United States of America	2018	Discovery of Kaposi's sarcoma herpesvirus-encoded circular RNAs and a human antiviral circular RNA.		kcirc54		viral lytic genes	KSHV infection / Kaposi's sarcoma herpesvirus infection	MONDO:0005055	Kaposi's sarcoma	up-regulated	RT-qPCR; RNA-seq	kcirc54 is a KSHV-encoded circular RNA detected among viral circRNAs expressed during the lytic phase and in KSHV-positive clinical samples. The paper does not provide a distinct kcirc54-specific mechanism beyond the general viral circRNA effects on viral gene expression and cell growth.	0.6392
30455306	Proceedings of the National Academy of Sciences of the United States of America	2018	Discovery of Kaposi's sarcoma herpesvirus-encoded circular RNAs and a human antiviral circular RNA.		kcirc55		viral lytic genes	KSHV infection / Kaposi's sarcoma herpesvirus infection	MONDO:0005055	Kaposi's sarcoma	up-regulated	RT-qPCR; RNA-seq	"kcirc55 is a KSHV-encoded circRNA enriched in the lytic phase and detected in KSHV-positive patient lymph nodes. It has reported progrowth functions and may act through RNA decoying or complementarity to cell cycle-related transcripts, while also mildly repressing RTA when highly expressed."	0.6642
30455306	Proceedings of the National Academy of Sciences of the United States of America	2018	Discovery of Kaposi's sarcoma herpesvirus-encoded circular RNAs and a human antiviral circular RNA.		kcirc97		viral lytic genes	KSHV infection / Kaposi's sarcoma herpesvirus infection	MONDO:0005055	Kaposi's sarcoma	up-regulated	RT-qPCR; RNA-seq	"kcirc97 is a KSHV-encoded circRNA enriched in the lytic phase and detected in KSHV-positive patient lymph nodes. It has reported progrowth functions and may act through RNA decoying or complementarity to cell cycle-related transcripts, while also mildly repressing RTA when highly expressed."	0.6642
30461077	Journal of clinical laboratory analysis	2019	Hsa_circ_0000467 promotes cancer progression and serves as a diagnostic and prognostic biomarker for gastric cancer.	hsa_circ_0000467		hsa_circ_Ska3	Ska3	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"This study shows that hsa_circ_0000467 is significantly upregulated in gastric cancer tissues, plasma, and cell lines. It promotes GC cell proliferation, migration, and invasion while inhibiting apoptosis, and its high expression is associated with advanced stage and poor prognosis. The circRNA may serve as a noninvasive diagnostic and prognostic biomarker and a potential therapeutic target in gastric cancer."	0.7888
30468709	Archives of biochemistry and biophysics	2019	CircZFR promotes hepatocellular carcinoma progression through regulating miR-3619-5p/CTNNB1 axis and activating Wnt/beta-catenin pathway.	hsa_circ_0072088	circZFR / circRNAZFR	hsa_circ_ZFR	ZFR	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circZFR is up-regulated in HCC tissues and cell lines and high expression predicts poor overall survival. Functionally, circZFR promotes HCC cell proliferation and EMT, and mechanistically it acts through the miR-3619-5p/CTNNB1 axis to activate Wnt/beta-catenin signaling."	0.7325
30470570	Biochemical and biophysical research communications	2019	CircRNA has_circ_0006427 suppresses the progression of lung adenocarcinoma by regulating miR-6783-3p/DKK1 axis and inactivating Wnt/beta-catenin signaling pathway.	hsa_circ_0006427	circ_0006427	hsa_circ_BCAR3	BCAR3	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; Microarray	"circ_0006427 is down-regulated in LUAD tissues and cell lines, and low expression is associated with advanced disease features and poor prognosis. Functionally, circ_0006427 acts as a tumor suppressor by inhibiting LUAD cell proliferation, migration, invasion, EMT, and in vivo tumor growth. Mechanistically, cytoplasmic circ_0006427 sponges miR-6783e3p/miR-6783-3p to upregulate DKK1 and thereby inactivate the Wnt/beta-catenin signaling pathway."	0.8657
30471855	Biochemical and biophysical research communications	2019	"Screening and bioinformatics analysis of mRNA, long non-coding RNA and circular RNA expression profiles in mucoepidermoid carcinoma of salivary gland."	hsa_circ_0012342	circ012342			Mucoepidermoid carcinoma of salivary gland / MEC	MONDO:0021009	salivary gland mucoepidermoid carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0012342/circ012342 was identified by microarray as a differentially expressed circRNA in MEC and confirmed by qRT-PCR, with decreased expression related to MEC pathogenesis. Bioinformatics analysis predicted that it may function through circRNA-miRNA interactions involving hsa_let-7e-5p, hsa_miR-107, and hsa_miR-214-3p. The study proposed it as a potential prognostic biomarker and therapeutic target for MEC."	0.4032
30478938	Journal of cellular physiology	2019	CircRNA ZNF609 functions as a competitive endogenous RNA to regulate FOXP4 expression by sponging miR-138-5p in renal carcinoma.	hsa_circ_0000615	circRNA ZNF609 / circ-ZNF609	hsa_circ_ZNF609	ZNF609	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR; Microarray	"circ-ZNF609 is up-regulated in renal carcinoma cell lines and promotes renal carcinoma cell proliferation and invasion. Mechanistically, it acts as a ceRNA by sponging miR-138-5p, thereby increasing FOXP4 expression through the circ-ZNF609/miR-138-5p/FOXP4 axis."	0.7328
30481761	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	Thymosin-beta4 Mediates Hepatic Stellate Cell Activation by Interfering with CircRNA-0067835/miR-155/FoxO3 Signaling Pathway.		circRNA-0067835			liver fibrosis	MONDO:0005155	cirrhosis of liver	up-regulated	RT-qPCR; Microarray	"circRNA-0067835 is up-regulated in liver fibrosis-related models, including Tbeta4-depleted LX-2 cells, activated HSCs, and CCl4-treated liver. Functionally, it promotes LX-2 cell proliferation and cell-cycle progression while suppressing apoptosis. Mechanistically, circRNA-0067835 acts as a miR-155 sponge to promote FOXO3a expression and modulate AKT/FOXO3a signaling, suggesting potential therapeutic relevance in liver fibrosis."	0.6737
30483740	Molecular medicine reports	2019	Characterization of circRNA_associated ceRNA networks in patients with nonvalvular persistent atrial fibrillation.		hsa_circRNA002085	hsa_circ_CACNB2	CACNB2	atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	up-regulated	RNA-seq	hsa_circRNA002085 is up-regulated in NPAF left atrial appendage tissue and is derived from CACNB2. The study predicts that it may interact with hsa-miR-21 in a circRNA-miRNA ceRNA network relevant to AF pathogenesis and biomarker discovery.	0.348
30483740	Molecular medicine reports	2019	Characterization of circRNA_associated ceRNA networks in patients with nonvalvular persistent atrial fibrillation.		hsa_circRNA001321	hsa_circ_CAMSAP2	CAMSAP2	atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	up-regulated	RNA-seq	hsa_circRNA001321 is up-regulated in NPAF left atrial appendage tissue and is derived from CAMSAP2. The study predicts that it may interact with hsa-miR-1 in a circRNA-miRNA ceRNA network relevant to NPAF pathogenesis and potential AF biomarker development.	0.348
30483740	Molecular medicine reports	2019	Characterization of circRNA_associated ceRNA networks in patients with nonvalvular persistent atrial fibrillation.		hsa_circRNA004558	hsa_circ_ATP2A2	ATP2A2	atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	down-regulated	RNA-seq	"hsa_circRNA004558 is down-regulated in NPAF and is derived from ATP2A2. It was included in the predicted circRNA-ceRNA network and may interact with miR-208b, suggesting a possible AF regulatory mechanism."	0.348
30483740	Molecular medicine reports	2019	Characterization of circRNA_associated ceRNA networks in patients with nonvalvular persistent atrial fibrillation.		hsa_circRNA003878	hsa_circ_CACNA1C	CACNA1C	atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	up-regulated	RNA-seq	"hsa_circRNA003878 is up-regulated in NPAF and originates from CACNA1C. It was predicted to target miR-4732-3p, linking it to a possible circRNA-miRNA regulatory mechanism relevant to TGF-beta/Smad-related atrial fibrosis biology."	0.348
30483740	Molecular medicine reports	2019	Characterization of circRNA_associated ceRNA networks in patients with nonvalvular persistent atrial fibrillation.		hsa_circRNA003884	hsa_circ_CACNA1C	CACNA1C	atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	up-regulated	RNA-seq	hsa_circRNA003884 is up-regulated in NPAF and originates from CACNA1C. The study predicts that it targets miR-4732-3p and may participate in circRNA-miRNA regulatory networks relevant to AF-related atrial remodeling.	0.348
30483740	Molecular medicine reports	2019	Characterization of circRNA_associated ceRNA networks in patients with nonvalvular persistent atrial fibrillation.		hsa_circRNA003876	hsa_circ_CACNA1C	CACNA1C	atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	up-regulated	RNA-seq	"hsa_circRNA003876 is up-regulated in NPAF and is derived from CACNA1C. It was predicted to target miR-4732-3p, suggesting possible involvement in circRNA-miRNA regulatory mechanisms linked to atrial fibrosis pathways."	0.348
30483740	Molecular medicine reports	2019	Characterization of circRNA_associated ceRNA networks in patients with nonvalvular persistent atrial fibrillation.		hsa_circRNA007411	hsa_circ_EFCAB13	EFCAB13	atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	up-regulated	RNA-seq	"hsa_circRNA007411 is up-regulated in NPAF and is derived from EFCAB13. It was selected for circRNA-ceRNA network analysis because of its calcium-associated parental gene context, but the text does not specify an individual miRNA interaction."	0.348
30483740	Molecular medicine reports	2019	Characterization of circRNA_associated ceRNA networks in patients with nonvalvular persistent atrial fibrillation.		hsa_circRNA007410	hsa_circ_EFCAB13	EFCAB13	atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	up-regulated	RNA-seq	"hsa_circRNA007410 is up-regulated in NPAF and is derived from EFCAB13. It was included among calcium-associated parental-gene circRNAs selected for predicted ceRNA network construction, although no specific individual miRNA partner is stated in the text."	0.348
30483740	Molecular medicine reports	2019	Characterization of circRNA_associated ceRNA networks in patients with nonvalvular persistent atrial fibrillation.		hsa_circRNA011785	hsa_circ_CADPS	CADPS	atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	up-regulated	RNA-seq	"hsa_circRNA011785 is up-regulated in NPAF and is derived from CADPS. It was selected for predicted ceRNA network analysis because of its calcium-associated parental gene context, but the text does not name a specific interacting miRNA."	0.348
30488762	"Cell cycle (Georgetown, Tex.)"	2018	CircPCNXL2 sponges miR-153 to promote the proliferation and invasion of renal cancer cells through upregulating ZEB2.		hsa_circRNA_406752 / circ-PCNXL2	hsa_circ_PCNXL2	PCNXL2	clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR; Microarray	"circPCNXL2 is a human PCNXL2-derived circRNA that is up-regulated in ccRCC tissues and RCC cell lines and whose high expression predicts poor overall survival. Functionally, circPCNXL2 promotes RCC cell proliferation, cell-cycle progression, invasion, and xenograft tumor growth. Mechanistically, it acts as a miR-153 sponge to upregulate ZEB2, forming a circPCNXL2/miR-153/ZEB2 regulatory axis."	0.8146
30504704	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	Increased Expression of Circular RNA circ_0005230 Indicates Dismal Prognosis in Breast Cancer and Regulates Cell Proliferation and Invasion via miR-618/ CBX8 Signal Pathway.	hsa_circ_0005230	circ_0005230	hsa_circ_DNM3OS	DNM3OS	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0005230 is up-regulated in breast cancer tissues and cell lines and is associated with aggressive clinicopathological features and poor overall survival. Functionally, it promotes breast cancer cell proliferation, tumor growth, migration and invasion while inhibiting apoptosis. Mechanistically, circ_0005230 sponges miR-618 to relieve repression of CBX8, forming a circ_0005230/miR-618/CBX8 oncogenic regulatory axis."	0.7528
30508543	International journal of biological macromolecules	2019	CircVRK1 regulates tumor progression and radioresistance in esophageal squamous cell carcinoma by regulating miR-624-3p/PTEN/PI3K/AKT signaling pathway.		circVRK1	hsa_circ_VRK1	VRK1	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	RT-qPCR	"circVRK1 is downregulated in ESCC tissues and cell lines, and higher circVRK1 expression is associated with better overall survival. Functionally, circVRK1 suppresses ESCC cell proliferation, migration, EMT and radioresistance. Mechanistically, circVRK1 sponges miR-624-3p to upregulate PTEN and inhibit PI3K/AKT signaling."	0.7759
30509102	Neoplasma	2019	Downregulation of hsa_circ_0000285 serves as a prognostic biomarker for bladder cancer and is involved in cisplatin resistance.	hsa_circ_0000285	circRNA_000285	hsa_circ_HIPK3	HIPK3	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR	"hsa_circ_0000285, derived from the HIPK3 locus, is significantly downregulated in bladder cancer tissues, serum, and bladder cancer cell lines. Lower expression is associated with cisplatin resistance, larger and more advanced tumors, metastasis-related clinical features, and poorer overall survival, supporting its use as a diagnostic, prognostic, and chemotherapy-response biomarker."	0.4187
30509491	Biochemical and biophysical research communications	2019	"Circular RNA hsa_circ_0004015 regulates the proliferation, invasion, and TKI drug resistance of non-small cell lung cancer by miR-1183/PDPK1 signaling pathway."	hsa_circ_0004015	circ_0004015	hsa_circ_CDK14	CDK14	Non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0004015 is up-regulated in NSCLC tissues and cell lines and is associated with poorer overall survival. Functionally, it promotes NSCLC cell viability, proliferation, invasion, xenograft growth, and gefitinib resistance. Mechanistically, it acts through the miR-1183/PDPK1 regulatory axis, consistent with a ceRNA-like oncogenic role."	0.7761
30520100	Journal of cellular biochemistry	2019	Has_circ_0055625 from circRNA profile increases colon cancer cell growth by sponging miR-106b-5p.	hsa_circ_0055625	circ_0055625	hsa_circ_DUSP2	DUSP2	colon cancer	MONDO:0021063	malignant colon neoplasm	up-regulated	RT-qPCR; Microarray	"hsa_circ_0055625 is significantly up-regulated in colon cancer tissues and is associated with larger tumor size, advanced TNM stage, histological differentiation, and metastasis. Functionally, circ_0055625 promotes colon cancer cell proliferation, migration, and invasion through a miR-106b/ITGB8 regulatory axis, suggesting potential value as a colon cancer biomarker."	0.7404
30521417	"Cell cycle (Georgetown, Tex.)"	2018	Circlular RNA BARD1 (Hsa_circ_0001098) overexpression in breast cancer cells with TCDD treatment could promote cell apoptosis via miR-3942/BARD1 axis.	hsa_circ_0001098		hsa_circ_BARD1	BARD1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"Hsa_circ_0001098/circRNA_BARD1 is up-regulated in TCDD-treated breast cancer samples and MCF-7 cells. Its overexpression suppresses proliferation, arrests the cell cycle, promotes apoptosis, and inhibits xenograft tumor growth and metastasis, at least partly through the miR-3942-3p/BARD1 regulatory axis."	0.6835
30525215	Journal of cellular biochemistry	2019	Upregulation of circular RNA circ_0000502 predicts unfavorable prognosis in osteosarcoma and facilitates cell progression via sponging miR-1238.	hsa_circ_0000502	circ_0000502			osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"Circ_0000502 is up-regulated in osteosarcoma tissues and cell lines and is associated with more severe clinicopathological features and poor overall survival. Functionally, it promotes OS cell proliferation, migration, invasion, and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ_0000502 acts at least partly by sponging miR-1238."	0.7524
30528736	Biochemical and biophysical research communications	2019	CircPUM1 promotes the malignant behavior of lung adenocarcinoma by regulating miR-326.	hsa_circ_0000043		hsa_circ_PUM1	PUM1	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"circPUM1 is upregulated in LUAD tissues and cell lines and acts as an oncogenic circRNA. It promotes proliferation, migration, invasion and in vivo tumorigenesis while inhibiting apoptosis, mainly by sponging miR-326 and increasing Cyclin D1 and Bcl-2 expression. Its expression is positively associated with TNM stage, suggesting potential therapeutic relevance."	0.6544
30548670	Journal of cellular biochemistry	2019	Overexpressed circ_0029426 in glioblastoma forecasts unfavorable prognosis and promotes cell progression by sponging miR-197.	hsa_circ_0029426	hsa_circRNA_101213			glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR	"circ_0029426 is up-regulated in GBM tissues and cell lines and high expression predicts unfavorable prognosis. Functionally, it promotes GBM cell proliferation, migration and invasion while inhibiting apoptosis. Mechanistically, circ_0029426 acts as a sponge for miR-197, and its oncogenic role is partly dependent on miR-197 suppression."	0.7396
30551873	Biochemical and biophysical research communications	2019	Circular RNA circMTO1 suppresses bladder cancer metastasis by sponging miR-221 and inhibiting epithelial-to-mesenchymal transition.	hsa_circ_0007874		hsa_circ_MTO1	MTO1	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR	"circMTO1 is down-regulated in bladder cancer tissues and cell lines, and low expression is associated with metastasis and poorer patient survival. Functionally, circMTO1 suppresses bladder cancer migration, invasion, EMT, metastasis, and xenograft tumor growth by sponging miR-221 and modulating EMT markers including E-cadherin, N-cadherin, and vimentin."	0.7811
30551880	Biochemical and biophysical research communications	2019	Circular RNA circ_0034642 elevates BATF3 expression and promotes cell proliferation and invasion through miR-1205 in glioma.	hsa_circ_0034642	circ_0034642	hsa_circ_VPS18	VPS18	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ_0034642 is upregulated in glioma tissues and cell lines and is associated with larger tumor size, advanced WHO grade, and shorter survival. Functionally, it promotes glioma cell proliferation, migration, and invasion while inhibiting apoptosis. Mechanistically, circ_0034642 acts through the miR-1205/BATF3 axis, positively regulating BATF3 by sponging miR-1205."	0.7408
30556306	Journal of cellular biochemistry	2019	"Elevated expression of circular RNA circ_0008450 predicts dismal prognosis in hepatocellular carcinoma and regulates cell proliferation, apoptosis, and invasion via sponging miR-548p."	hsa_circ_0008450	circ_0008450			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0008450 is up-regulated in HCC tissues and cell lines and high expression predicts poor overall survival. Functionally, circ_0008450 promotes HCC cell proliferation, migration and invasion while suppressing apoptosis. Mechanistically, it acts at least partly by sponging and suppressing miR-548p."	0.7113
30563416	"Cell cycle (Georgetown, Tex.)"	2018	Microarray expression profile and analysis of circular RNA regulatory network in malignant pleural effusion.	hsa_circ_0067705				lung adenocarcinoma-associated malignant pleural effusion / LA-MPE	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; Microarray	hsa_circ_0067705 is one of the top five up-regulated circRNAs in LA-MPE and was validated as significantly increased by qRT-PCR. The study predicts that it may act through a circRNA-miRNA-mRNA ceRNA network involving cancer-related pathways such as PI3K-Akt signaling.	0.4032
30563416	"Cell cycle (Georgetown, Tex.)"	2018	Microarray expression profile and analysis of circular RNA regulatory network in malignant pleural effusion.	hsa_circ_0025542				lung adenocarcinoma-associated malignant pleural effusion / LA-MPE	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; Microarray	hsa_circ_0025542 is one of the top five up-regulated circRNAs in LA-MPE and was validated as significantly increased by qRT-PCR. It was incorporated into a predicted ceRNA network with three candidate miRNAs and downstream mRNAs enriched in cancer-related pathways.	0.4032
30563416	"Cell cycle (Georgetown, Tex.)"	2018	Microarray expression profile and analysis of circular RNA regulatory network in malignant pleural effusion.	hsa_circ_0072793				lung adenocarcinoma-associated malignant pleural effusion / LA-MPE	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; Microarray	hsa_circ_0072793 is one of the top five up-regulated circRNAs in LA-MPE and was detected in MPE but not in TPE by qRT-PCR validation. It was analyzed as part of a predicted circRNA-miRNA-mRNA network potentially regulating cancer-related pathways.	0.4032
30563416	"Cell cycle (Georgetown, Tex.)"	2018	Microarray expression profile and analysis of circular RNA regulatory network in malignant pleural effusion.	hsa_circ_0084927				lung adenocarcinoma-associated malignant pleural effusion / LA-MPE	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; Microarray	hsa_circ_0084927 is one of the top five up-regulated circRNAs in LA-MPE and was detected in MPE but not in TPE by qRT-PCR validation. The study predicts that it may participate in LA-MPE pathogenesis through a ceRNA regulatory network.	0.4032
30563416	"Cell cycle (Georgetown, Tex.)"	2018	Microarray expression profile and analysis of circular RNA regulatory network in malignant pleural effusion.	hsa_circ_0085386				lung adenocarcinoma-associated malignant pleural effusion / LA-MPE	MONDO:0008903	lung cancer	up-regulated	Microarray	"hsa_circ_0085386 is one of the top five up-regulated circRNAs identified by microarray in LA-MPE, but its qRT-PCR result showed only a non-significant increasing trend. It was included in the predicted circRNA-miRNA-mRNA network and pathway analysis."	0.348
30563889	Cancer research	2019	Cis-Acting circ-CTNNB1 Promotes beta-Catenin Signaling and Cancer Progression via DDX3-Mediated Transactivation of YY1.	hsa_circ_0123778	circ-CTNNB1	hsa_circ_CTNNB1	CTNNB1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Northern Blot; ISH	"Circ-CTNNB1 is a human CTNNB1-derived intronic circRNA that is upregulated in multiple cancer tissues and cell lines and predicts poor overall survival in gastric cancer. It predominantly localizes in the nucleus, binds DDX3, promotes DDX3-YY1 interaction and YY1 transactivation, increases Wnt/b-catenin-related target gene expression, and drives cancer growth, invasion, metastasis, angiogenesis, and aggressiveness."	0.8957
30563889	Cancer research	2019	Cis-Acting circ-CTNNB1 Promotes beta-Catenin Signaling and Cancer Progression via DDX3-Mediated Transactivation of YY1.	hsa_circ_0123778	circ-CTNNB1	hsa_circ_CTNNB1	CTNNB1	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Northern Blot; ISH	"Circ-CTNNB1 is a human CTNNB1-derived intronic circRNA that is upregulated in multiple cancer tissues and cell lines and predicts poor overall survival in gastric cancer. It predominantly localizes in the nucleus, binds DDX3, promotes DDX3-YY1 interaction and YY1 transactivation, increases Wnt/b-catenin-related target gene expression, and drives cancer growth, invasion, metastasis, angiogenesis, and aggressiveness."	0.8957
30563889	Cancer research	2019	Cis-Acting circ-CTNNB1 Promotes beta-Catenin Signaling and Cancer Progression via DDX3-Mediated Transactivation of YY1.	hsa_circ_0123778	circ-CTNNB1	hsa_circ_CTNNB1	CTNNB1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Northern Blot; ISH	"Circ-CTNNB1 is a human CTNNB1-derived intronic circRNA that is upregulated in multiple cancer tissues and cell lines and predicts poor overall survival in gastric cancer. It predominantly localizes in the nucleus, binds DDX3, promotes DDX3-YY1 interaction and YY1 transactivation, increases Wnt/b-catenin-related target gene expression, and drives cancer growth, invasion, metastasis, angiogenesis, and aggressiveness."	0.8957
30563889	Cancer research	2019	Cis-Acting circ-CTNNB1 Promotes beta-Catenin Signaling and Cancer Progression via DDX3-Mediated Transactivation of YY1.	hsa_circ_0020050				gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"hsa_circ_0020050 was identified during screening of potential cis-acting circRNAs and was reported to be upregulated in gastric cancer, prostate cancer, and colorectal cancer tissues. Unlike circ-CTNNB1, its knockdown did not attenuate b-catenin activity in the tested cancer cells, and no positive functional mechanism or clinical prognostic role was further established."	0.6368
30563889	Cancer research	2019	Cis-Acting circ-CTNNB1 Promotes beta-Catenin Signaling and Cancer Progression via DDX3-Mediated Transactivation of YY1.	hsa_circ_0020050				prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"hsa_circ_0020050 was identified during screening of potential cis-acting circRNAs and was reported to be upregulated in gastric cancer, prostate cancer, and colorectal cancer tissues. Unlike circ-CTNNB1, its knockdown did not attenuate b-catenin activity in the tested cancer cells, and no positive functional mechanism or clinical prognostic role was further established."	0.6368
30563889	Cancer research	2019	Cis-Acting circ-CTNNB1 Promotes beta-Catenin Signaling and Cancer Progression via DDX3-Mediated Transactivation of YY1.	hsa_circ_0020050				colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"hsa_circ_0020050 was identified during screening of potential cis-acting circRNAs and was reported to be upregulated in gastric cancer, prostate cancer, and colorectal cancer tissues. Unlike circ-CTNNB1, its knockdown did not attenuate b-catenin activity in the tested cancer cells, and no positive functional mechanism or clinical prognostic role was further established."	0.6368
30563889	Cancer research	2019	Cis-Acting circ-CTNNB1 Promotes beta-Catenin Signaling and Cancer Progression via DDX3-Mediated Transactivation of YY1.	hsa_circ_0004030				gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"hsa_circ_0004030 was identified during screening of potential cis-acting circRNAs and was reported to be upregulated in gastric cancer, prostate cancer, and colorectal cancer tissues. Unlike circ-CTNNB1, its knockdown did not attenuate b-catenin activity in the tested cancer cells, and no positive functional mechanism or clinical prognostic role was further established."	0.6368
30563889	Cancer research	2019	Cis-Acting circ-CTNNB1 Promotes beta-Catenin Signaling and Cancer Progression via DDX3-Mediated Transactivation of YY1.	hsa_circ_0004030				prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"hsa_circ_0004030 was identified during screening of potential cis-acting circRNAs and was reported to be upregulated in gastric cancer, prostate cancer, and colorectal cancer tissues. Unlike circ-CTNNB1, its knockdown did not attenuate b-catenin activity in the tested cancer cells, and no positive functional mechanism or clinical prognostic role was further established."	0.6368
30563889	Cancer research	2019	Cis-Acting circ-CTNNB1 Promotes beta-Catenin Signaling and Cancer Progression via DDX3-Mediated Transactivation of YY1.	hsa_circ_0004030				colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"hsa_circ_0004030 was identified during screening of potential cis-acting circRNAs and was reported to be upregulated in gastric cancer, prostate cancer, and colorectal cancer tissues. Unlike circ-CTNNB1, its knockdown did not attenuate b-catenin activity in the tested cancer cells, and no positive functional mechanism or clinical prognostic role was further established."	0.6368
30565694	Journal of cellular physiology	2019	CircRNA fibroblast growth factor receptor 3 promotes tumor progression in non-small cell lung cancer by regulating Galectin-1-AKT/ERK1/2 signaling.			hsa_circ_FGFR3	FGFR3	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circFGFR3 is up-regulated in human NSCLC tissues and is associated with poor clinical outcomes. Functionally, circFGFR3 promotes NSCLC cell proliferation and invasion. Mechanistically, it sponges miR-22-3p to increase Gal-1 expression and activate AKT and ERK1/2 signaling, suggesting a potential prognostic biomarker and therapeutic target role."	0.7113
30567979	Journal of virology	2019	Comparative Analysis of Gammaherpesvirus Circular RNA Repertoires: Conserved and Unique Viral Circular RNAs.		circRPMS1_E5_E3a	rLCV_circ_RPMS1	RPMS1	Gammaherpesvirus infection	MONDO:0005794	Herpesviridae infectious disease	unknown	RT-qPCR	"rLCV circRPMS1_E5'_E3a/circRPMS1_E5_E3a was detected in all three rLCV-positive lymphoma samples and experimentally validated as circular by divergent-primer PCR, RNase R resistance, and Sanger sequencing. The authors propose it is a functional homologue of EBV circRPMS1_E4_E3a with potentially conserved roles in virus infection biology and associated malignancies."	0.5971
30567979	Journal of virology	2019	Comparative Analysis of Gammaherpesvirus Circular RNA Repertoires: Conserved and Unique Viral Circular RNAs.		circRPMS1_E2b_E1b	rLCV_circ_RPMS1	RPMS1	Gammaherpesvirus infection	MONDO:0005794	Herpesviridae infectious disease	unknown	RT-qPCR	"rLCV circRPMS1_E2b_E1b/circRPMS1_E2b/E2b'_E1b was found in the two lytic rLCV lymphoma samples and validated as a circular RNA by divergent PCR, Sanger sequencing, and RNase R resistance. Because it spans a lytic origin of replication, the authors suggest it may be linked to lytic viral DNA replication, although direct function was not proven."	0.5971
30567979	Journal of virology	2019	Comparative Analysis of Gammaherpesvirus Circular RNA Repertoires: Conserved and Unique Viral Circular RNAs.		circEBNA_U / rLCV circEBNA_U	rLCV_circ_EBNA		Gammaherpesvirus infection	MONDO:0005794	Herpesviridae infectious disease	unknown	RT-qPCR	rLCV circEBNA_U was detected and validated in all three rLCV-positive lymphoma samples. It is described as a latency-associated circular RNA whose conservation with EBV circEBNA_U suggests possible functional significance in viral latency and lymphoma biology.	0.5971
30567979	Journal of virology	2019	Comparative Analysis of Gammaherpesvirus Circular RNA Repertoires: Conserved and Unique Viral Circular RNAs.		circvIRF4 / circular vIRF4 transcript	KSHV_circ_vIRF4	vIRF4	KSHV infection / Kaposi's sarcoma herpesvirus infection	MONDO:0005055	Kaposi's sarcoma	unknown	RT-qPCR	KSHV circvIRF4 was identified as the predominant latency-associated viral circRNA in KSHV-positive cell models. It forms two isoforms and may act as a non-coding latency transcript relevant to host-cell modulation during latency and KSHV-associated malignancies.	0.5193
30567979	Journal of virology	2019	Comparative Analysis of Gammaherpesvirus Circular RNA Repertoires: Conserved and Unique Viral Circular RNAs.		circM11_ORF69	MHV68_circ_M11_ORF69		MHV68 infection	MONDO:0005550	infectious disease	unknown	RT-qPCR	"MHV68 circM11_ORF69 was identified during lytic infection of NIH 3T12 cells and spans an MHV68 lytic origin of replication. It was supported by RNase R-seq, in silico junction validation, RNase R resistance, and PCR, and the authors propose that such OriLyt-associated circRNAs may participate in lytic viral DNA replication."	0.4276
30569515	Journal of cellular physiology	2019	Circular RNA hsa_circ_0000263 participates in cervical cancer development by regulating target gene of miR-150-5p.	hsa_circ_0000263	circ-0000263			cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000263 is up-regulated in cervical cancer cell lines and functions as an oncogenic circRNA. It promotes proliferation, migration, tumor growth and lung metastasis while inhibiting apoptosis, at least partly through the hsa_circ_0000263/miR-150-5p/MDM4/p53 regulatory network."	0.7898
30576257	Physiological genomics	2019	Differential circRNA expression profiles in latent human cytomegalovirus infection and validation using clinical samples.	hsa_circ_0001445				cytomegalovirus infection	MONDO:0005132	cytomegalovirus infection	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0001445 was identified in HCMV latent-infected THP-1 cells and validated in pediatric whole-blood clinical samples. It was significantly down-regulated in HCMV infection and showed potential diagnostic biomarker value with an AUC of 0.779.	0.6731
30576257	Physiological genomics	2019	Differential circRNA expression profiles in latent human cytomegalovirus infection and validation using clinical samples.	hsa_circ_0001206				cytomegalovirus infection	MONDO:0005132	cytomegalovirus infection	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001206 was identified in HCMV latent-infected THP-1 cells and validated in pediatric whole-blood clinical samples. It was significantly down-regulated in HCMV infection, was predicted to interact with hsa-miR-4746-5p, and showed potential diagnostic biomarker value with an AUC of 0.840."	0.6957
30576808	Gene	2019	Circular RNA HIPK3 promotes glioma progression by binding to miR-124-3p.	hsa_circ_0000284	Circular RNA HIPK3 / circ-HIPK3	hsa_circ_HIPK3	HIPK3	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"hsa_circ_0000284/circ-HIPK3 is up-regulated in human glioma cell lines. It promotes glioma cell proliferation, invasion, migration and cell cycle progression while suppressing apoptosis, mainly by acting as a cytoplasmic sponge for miR-124-3p and thereby increasing STAT3 expression. The study suggests a circ-HIPK3/miR-124-3p/STAT3 axis as a potential mechanism and possible therapeutic target in glioma."	0.7221
30590312	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2019	Circular RNA PVT1 acts as a competing endogenous RNA for miR-497 in promoting non-small cell lung cancer progression.		Circular RNA PVT1 / circPVT1	hsa_circ_PVT1	PVT1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circPVT1 is up-regulated in NSCLC tissues and cell lines, and high expression is associated with larger tumor size, advanced TNM stage, and shorter overall survival. Functionally, circPVT1 promotes NSCLC proliferation and tumor growth while inhibiting apoptosis through a ceRNA mechanism involving miR-497 and Bcl-2."	0.7396
30591218	Biochemical and biophysical research communications	2019	Upregulated circular RNA circ_0030235 predicts unfavorable prognosis in pancreatic ductal adenocarcinoma and facilitates cell progression by sponging miR-1253 and miR-1294.	hsa_circ_0030235	circ_0030235	hsa_circ_RCBTB2	RCBTB2	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR	"circ_0030235 is upregulated in PDAC tissues and cell lines and its high expression predicts unfavorable prognosis. Functionally, it promotes PDAC cell proliferation, migration and invasion while suppressing apoptosis. Mechanistically, circ_0030235 acts as a sponge for miR-1253 and miR-1294, and its oncogenic effects are partly dependent on repression of these miRNAs."	0.7113
30597308	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2019	Comprehensive circular RNA profiling of proliferative vitreoretinopathy and its clinical significance.	hsa_circ_0043144	circ_0043144			Proliferative vitreoretinopathy / PVR	MONDO:0700115	proliferative vitreoretinopathy	up-regulated	RT-qPCR; Microarray	"hsa_circ_0043144/circ_0043144 is up-regulated in PVR epiretinal membranes, vitreous, and serum samples, and its level is associated with PVR severity. Functional assays in ARPE-19 cells indicate that circ_0043144 promotes RPE proliferation, migration, and secretion of CCL2, CXCL8, IL-6, and VEGF-A, suggesting a role in epiretinal membrane formation and PVR progression. The study proposes circ_0043144 as a potential circulating diagnostic and prognostic biomarker for PVR."	0.6777
30608205	RNA biology	2019	Circular RNA Vav3 sponges gga-miR-375 to promote epithelial-mesenchymal transition.		circRNA Vav3 / circ-Vav3 (chr8:1033880-1047222-)	gga_circ_VAV3	VAV3	ALV-J-induced liver tumor	MONDO:0024477	liver and intrahepatic bile duct neoplasm	up-regulated	RT-qPCR; RNA-seq	"circ-Vav3 is a chicken VAV3-derived circRNA upregulated in ALV-J-induced tumor livers and ALV-J-infected DF-1 cells. It localizes in the cytoplasm, sponges gga-miR-375 via AGO2-associated interaction, increases YAP1 expression, and promotes EMT-associated tumorigenesis."	0.8058
30611100	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2019	Up-regulation of circ-SMAD7 inhibits tumor proliferation and migration in esophageal squamous cell carcinoma.		circ-SMAD7	hsa_circ_SMAD7	SMAD7	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	"circ-SMAD7 is a human circRNA derived from intron 1 of SMAD7 and is down-regulated in ESCC plasma, tissues, and cell lines. Its low expression is associated with advanced TNM stage and lymphatic metastasis, while overexpression suppresses ESCC cell proliferation and migration, supporting its potential as a diagnostic and therapeutic biomarker."	0.7766
30612066	"Blood cells, molecules & diseases"	2019	Silencing of circ_0009910 inhibits acute myeloid leukemia cell growth through increasing miR-20a-5p.	hsa_circ_0009910	circ_0009910 / hsa_circRNA_100053	hsa_circ_MFN2		acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; Microarray	"circ_0009910 is up-regulated in AML bone marrow samples and leukemia cell lines, and high expression is associated with poor-risk disease and shorter overall survival. Functionally, circ_0009910 promotes AML5 cell proliferation, cell cycle progression, and xenograft growth while suppressing apoptosis. Mechanistically, it acts through miR-20a-5p sponging/inhibition, and circ_0009910 knockdown increases miR-20a-5p to suppress AML cell growth."	0.8416
30630646	"Pathology, research and practice"	2019	Inhibition of hsa_circ_0001313 (circCCDC66) induction enhances the radio-sensitivity of colon cancer cells via tumor suppressor miR-338-3p: Effects of cicr_0001313 on colon cancer radio-sensitivity.	hsa_circ_0001313		hsa_circ_CCDC66	CCDC66	colon cancer	MONDO:0021063	malignant colon neoplasm	up-regulated	RT-qPCR	"hsa_circ_0001313/circCCDC66 is up-regulated in radio-resistant colon cancer tissues and is induced by irradiation in colon cancer cells. Its knockdown enhances radiosensitivity by reducing cell viability and colony formation and increasing caspase-3 activity. Mechanistically, circ_0001313 functions as a miR-338-3p sponge and negatively regulates miR-338-3p, suggesting a potential therapeutic target for radio-resistant colon cancer."	0.6903
30633364	Journal of cellular physiology	2019	CircRNA hsa_circRNA_101996 increases cervical cancer proliferation and invasion through activating TPX2 expression by restraining miR-8075.		hsa_circRNA_101996			cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_101996 is up-regulated in cervical cancer tissues and cell lines, and high expression is associated with advanced stage, larger tumor size, lymph node metastasis, and poor survival. Functionally, it promotes cervical cancer proliferation, cell cycle progression, migration, invasion, and xenograft tumor growth. Mechanistically, it acts as a cytoplasmic miR-8075 sponge to increase TPX2 expression, forming a hsa_circRNA_101996-miR-8075-TPX2 regulatory network that promotes cervical cancer progression."	0.7733
30644610	Molecular carcinogenesis	2019	Antitumor effects of circ-EPHB4 in hepatocellular carcinoma via inhibition of HIF-1alpha.	hsa_circ_0001730	circ-EPHB4	hsa_circ_EPHB4	EPHB4	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"circ-EPHB4 (hsa_circ_0001730), derived from EPHB4, is downregulated in HCC tissues and shows biomarker potential by ROC analysis. Functionally, circ-EPHB4 suppresses HCC cell proliferation, migration, invasion, tumorigenesis and metastasis while promoting apoptosis. Mechanistically, its antitumor effect is mediated through inhibition of HIF-1alpha expression and downstream suppression of HIF-1alpha-related PI3K-AKT and ZEB1/EMT signaling."	0.7944
30651325	The Journal of neuroscience : the official journal of the Society for Neuroscience	2019	MicroRNA-1224 Splicing CircularRNA-Filip1l in an Ago2-Dependent Manner Regulates Chronic Inflammatory Pain via Targeting Ubr5.	mmu_circ_0000691	circRNA-Filip1l / circRNA-005252	mmu_circ_Filip1l	Filip1l	inflammatory pain	MONDO:0021166	inflammatory disease	up-regulated	RT-qPCR; Northern Blot; ISH; Microarray	"In mouse chronic inflammatory pain models, circRNA-Filip1l is up-regulated in spinal neurons, especially in the ipsilateral spinal dorsal horn. Its overexpression promotes nociceptive behaviors, whereas its blockade alleviates thermal hyperalgesia and mechanical allodynia. Mechanistically, miRNA-1224/Ago2 negatively regulates circRNA-Filip1l biogenesis, and circRNA-Filip1l promotes nociception via targeting Ubr5."	0.8109
30657346	Epigenomics	2019	Circular RNA circASS1 is downregulated in breast cancer cells MDA-MB-231 and suppressed invasion and migration.	hsa_circ_0089105	circASS1	hsa_circ_ASS1	ASS1	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	"circASS1 is down-regulated in the more aggressive breast cancer cell line MDA-MB-231 compared with MCF-7. Functionally, circASS1 suppresses breast cancer cell invasion and migration, likely through sponging miR-4443 and upregulating its parental gene ASS1."	0.7519
30659640	Journal of cellular biochemistry	2019	Circular RNA circ-PRKCI functions as a competitive endogenous RNA to regulate AKT3 expression by sponging miR-3680-3p in esophageal squamous cell carcinoma.	hsa_circ_0067934	circ-PRKCI	hsa_circ_PRKCI	PRKCI	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"circ-PRKCI is upregulated in ESCC tissues and promotes ESCC cell proliferation and migration. Mechanistically, it acts as a ceRNA by sponging miR-3680-3p, thereby upregulating AKT3 expression in the circ-PRKCI/miR-3680-3p/AKT3 regulatory network."	0.8162
30663767	Journal of cellular physiology	2019	Circular RNA circ_0001946 acts as a competing endogenous RNA to inhibit glioblastoma progression by modulating miR-671-5p and CDR1.	hsa_circ_0001946		hsa_circ_CDR1	CDR1	glioblastoma / GBM	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR; RNA-seq; Microarray	"circ_0001946 is down-regulated in GBM and functions as a tumor suppressor. It sponges miR-671-5p to increase CDR1 expression, thereby inhibiting GBM cell proliferation, migration, invasion, and xenograft tumor growth while promoting apoptosis. The circ_0001946/miR-671-5p/CDR1 axis is proposed as a potential therapeutic target for GBM."	0.697
30664179	Oncology reports	2019	Expression profiles and potential functions of circular RNAs in extracellular vesicles isolated from radioresistant glioma cells.		circATP8B4	hsa_circ_ATP8B4	ATP8B4	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; RNA-seq	"circATP8B4 was up-regulated in extracellular vesicles derived from radioresistant U251 glioma cells compared with normal U251-derived EVs, and this expression change was validated by RT-qPCR. The study suggests that RR-EV-derived circATP8B4 may be transferred to recipient glioma cells and act as a miR-766-5p sponge in a predicted ceRNA mechanism, thereby promoting glioma cell radioresistance and potentially serving as a biomarker for glioma radioresistance."	0.4851
30664808	Experimental dermatology	2019	Mesenchymal stem cells in psoriatic lesions affect the skin microenvironment through circular RNA.		chr2:206992521|206994966			psoriasis	MONDO:0005083	psoriasis	down-regulated	RT-qPCR; RNA-seq	"chr2:206992521|206994966 is a down-regulated circRNA in skin-derived mesenchymal stem cells from psoriatic lesions. Its knockdown in normal S-MSCs mimicked psoriatic S-MSCs by weakening inhibition of T-cell proliferation and altering cytokine secretion, supporting a role in psoriasis-associated immune dysregulation through a predicted circRNA-miRNA-mRNA mechanism."	0.6676
30666650	The Journal of pathology	2019	NSD2 circular RNA promotes metastasis of colorectal cancer by targeting miR-199b-5p-mediated DDR1 and JAG1 signalling.	hsa_circ_0008460		hsa_circ_NSD2	NSD2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"This study identifies circ-NSD2 as an up-regulated, conserved circular RNA in colorectal cancer and CRC metastasis. circ-NSD2 mainly localizes to the cytoplasm and promotes CRC cell migration, invasion and metastasis by sponging miR-199b-5p, thereby increasing DDR1 and JAG1 expression. Clinically, its elevated expression in CRC tissues, advanced stages and metastatic tumours suggests potential value as a prognostic marker and therapeutic target."	0.8448
30666650	The Journal of pathology	2019	NSD2 circular RNA promotes metastasis of colorectal cancer by targeting miR-199b-5p-mediated DDR1 and JAG1 signalling.		cmm9_circ_003195	mmu_circ_NSD2	NSD2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"This study identifies circ-NSD2 as an up-regulated, conserved circular RNA in colorectal cancer and CRC metastasis. circ-NSD2 mainly localizes to the cytoplasm and promotes CRC cell migration, invasion and metastasis by sponging miR-199b-5p, thereby increasing DDR1 and JAG1 expression. Clinically, its elevated expression in CRC tissues, advanced stages and metastatic tumours suggests potential value as a prognostic marker and therapeutic target."	0.8448
30681027	Journal of neurotrauma	2019	Differential Expression Profiles and Functional Predication of Circular Ribonucleic Acid in Traumatic Spinal Cord Injury of Rats.		circRNA_11070			spinal cord injury / SCI	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR; RNA-seq	circRNA_11070 was significantly up-regulated in rat spinal cord after traumatic SCI and its expression change was verified by qRT-PCR. The paper did not report a specific molecular mechanism or functional assay for this circRNA.	0.4625
30681027	Journal of neurotrauma	2019	Differential Expression Profiles and Functional Predication of Circular Ribonucleic Acid in Traumatic Spinal Cord Injury of Rats.		circRNA_08027			spinal cord injury / SCI	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR; RNA-seq	circRNA_08027 was significantly up-regulated in rat spinal cord after traumatic SCI and its expression change was verified by qRT-PCR. The paper did not report a specific molecular mechanism or functional assay for this circRNA.	0.4625
30681027	Journal of neurotrauma	2019	Differential Expression Profiles and Functional Predication of Circular Ribonucleic Acid in Traumatic Spinal Cord Injury of Rats.		circRNA_01373			spinal cord injury / SCI	MONDO:0043797	spinal cord injury	down-regulated	RT-qPCR; RNA-seq	circRNA_01373 was significantly down-regulated in rat spinal cord after traumatic SCI and its expression change was verified by qRT-PCR. The paper did not report a specific molecular mechanism or functional assay for this circRNA.	0.4625
30681027	Journal of neurotrauma	2019	Differential Expression Profiles and Functional Predication of Circular Ribonucleic Acid in Traumatic Spinal Cord Injury of Rats.		circRNA_06211			spinal cord injury / SCI	MONDO:0043797	spinal cord injury	down-regulated	RT-qPCR; RNA-seq	circRNA_06211 was significantly down-regulated in rat spinal cord after traumatic SCI and its expression change was verified by qRT-PCR. The paper did not report a specific molecular mechanism or functional assay for this circRNA.	0.4625
30681027	Journal of neurotrauma	2019	Differential Expression Profiles and Functional Predication of Circular Ribonucleic Acid in Traumatic Spinal Cord Injury of Rats.		circRNA_07079			spinal cord injury / SCI	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR; RNA-seq	circRNA_07079 was significantly and dynamically up-regulated in rat spinal cord after traumatic SCI. The study predicts that circRNA_07079 may act as a sponge of miR-351-5/miR-351-5p and participate in SCI pathophysiology through a circRNA-miRNA-mRNA axis involving pathways such as AMPK and cAMP signaling.	0.5922
30681027	Journal of neurotrauma	2019	Differential Expression Profiles and Functional Predication of Circular Ribonucleic Acid in Traumatic Spinal Cord Injury of Rats.		circRNA_01282			spinal cord injury / SCI	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR; RNA-seq	circRNA_01282 was significantly and dynamically up-regulated in rat spinal cord after traumatic SCI. The study predicts that circRNA_01282 may act as a sponge of miR-351-5/miR-351-5p and participate in SCI pathophysiology through a circRNA-miRNA-mRNA axis involving pathways such as AMPK and cAMP signaling.	0.5922
30688097	"Artificial cells, nanomedicine, and biotechnology"	2019	Hsa_circ_0067997 promotes the progression of gastric cancer by inhibition of miR-515-5p and activation of X chromosome-linked inhibitor of apoptosis (XIAP).	hsa_circ_0067997	circ_0067997	hsa_circ_FNDC3B	FNDC3B	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"Hsa_circ_0067997 is up-regulated in gastric cancer tissues and cell lines and its high expression is associated with worse overall survival. Functionally, it promotes GC cell viability, colony formation, invasion, and xenograft tumor growth. Mechanistically, circ_0067997 acts as a sponge for miR-515-5p, upregulates XIAP, and drives GC progression through the circ_0067997/miR-515-5p/XIAP axis."	0.7967
30689557	Cancer biomarkers : section A of Disease markers	2020	Circular RNA hsa_circRNA_102958 may serve as a diagnostic marker for gastric cancer.		hsa_circRNA_102958			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"This study identified hsa_circRNA_102958 as an up-regulated circRNA in gastric cancer tissues and cell lines using microarray screening and qRT-PCR validation. Its expression was associated with TNM stage and showed moderate diagnostic performance by ROC analysis. The authors also predicted a hsa_circRNA_102958-miRNA-mRNA network involving five miRNAs, suggesting a possible ceRNA-related regulatory role."	0.5963
30692016	Molecular therapy : the journal of the American Society of Gene Therapy	2019	circRNA.33186 Contributes to the Pathogenesis of Osteoarthritis by Sponging miR-127-5p.		circRNA.33186	mmu_circ_Umad1	Umad1	Osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"This study identifies mouse circRNA.33186, derived from Umad1, as an up-regulated circRNA in IL-1beta-treated chondrocytes and DMM-induced OA cartilage. circRNA.33186 promotes OA pathogenesis by sponging miR-127-5p and increasing MMP-13, while its silencing restores anabolic/catabolic balance, promotes chondrocyte proliferation, inhibits apoptosis, and alleviates OA in vivo. The authors propose circRNA.33186 as a potential diagnostic biomarker and therapeutic target for OA."	0.78
30692017	Molecular therapy : the journal of the American Society of Gene Therapy	2019	Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance.	hsa_circ_0001258				osteosarcoma / OS	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0001258 is down-regulated in chemo-resistant osteosarcoma cell lines and tissues. It suppresses doxorubicin resistance through a ceRNA mechanism by sponging hsa-miR-744-3p and increasing GSTM2 expression.	0.6676
30692017	Molecular therapy : the journal of the American Society of Gene Therapy	2019	Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance.	hsa_circ_0004674				osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RNA-seq	hsa_circ_0004674 was identified by whole-transcriptome RNA-seq as the most upregulated circRNA in chemo-resistant osteosarcoma cell lines. The article did not report RT-qPCR validation or functional/mechanistic experiments for this specific circRNA.	0.1155
30692017	Molecular therapy : the journal of the American Society of Gene Therapy	2019	Analyzing the Interactions of mRNAs and ncRNAs to Predict Competing Endogenous RNA Networks in Osteosarcoma Chemo-Resistance.	hsa_circ_0068458				osteosarcoma / OS	MONDO:0009807	osteosarcoma	down-regulated	RNA-seq	hsa_circ_0068458 was identified by whole-transcriptome RNA-seq as the most downregulated circRNA in chemo-resistant osteosarcoma cell lines. The article did not report RT-qPCR validation or functional/mechanistic experiments for this specific circRNA.	0.1155
30709584	Biochemical and biophysical research communications	2019	Upregulated circular RNA circ_0025033 promotes papillary thyroid cancer cell proliferation and invasion via sponging miR-1231 and miR-1304.	hsa_circ_0025033		hsa_circ_FOXM1	FOXM1	papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0025033 is up-regulated in papillary thyroid cancer tissues and cell lines. It acts as an oncogenic circRNA that promotes proliferation, colony formation, migration and invasion while inhibiting apoptosis, mainly through sponging and suppressing miR-1231 and miR-1304."	0.6815
30710798	Virology	2019	Identification of virus-encoded circular RNA.		ebv-circRPMS1	ebv_circ_RPMS1	RPMS1	EBV-associated gastric carcinoma / EBVaGC	MONDO:0017784	Epstein-Barr virus-associated gastric carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"This study identified ebv-circRPMS1 as an EBV-encoded circular RNA derived from exons 2-4 of the RPMS1 gene and detected it in EBV-positive cell lines, xenografts, EBVaGC tissue, and NPC tissue. ebv-circRPMS1 localizes in both the cytoplasm and nucleus, may function as a miRNA sponge for human and EBV miRNAs, downregulates several human miRNAs upon overexpression, and promotes AGS cell migration in wound healing assays."	0.7562
30716279	Clinica chimica acta; international journal of clinical chemistry	2019	Using circular RNA SMARCA5 as a potential novel biomarker for hepatocellular carcinoma.			hsa_circ_SMARCA5	SMARCA5	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"CircSMARCA5 is down-regulated in HCC tissues and plasma, and lower expression is associated with more aggressive clinicopathological features. Functionally, circSMARCA5 overexpression suppresses HCC cell proliferation, invasion/metastasis-related markers, and promotes apoptosis, accompanied by reduced MMP7 and MMP9 expression. Plasma circSMARCA5 shows diagnostic potential for HCC, including in patients with AFP below the cutoff value."	0.6211
30719761	Journal of cellular biochemistry	2019	Enhanced expression of circ_0000267 in hepatocellular carcinoma indicates poor prognosis and facilitates cell progression by sponging miR-646.	hsa_circ_0000267	circ_0000267			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0000267 is up-regulated in HCC tissues and cell lines and its high expression is associated with larger tumor size, advanced TNM stage, and poor overall survival. Functionally, it promotes HCC cell proliferation, migration, invasion and metastatic properties while inhibiting apoptosis. Mechanistically, circ_0000267 acts as an oncogenic circRNA partly by sponging miR-646."	0.7396
30721952	The Journal of clinical endocrinology and metabolism	2019	circOMA1-Mediated miR-145-5p Suppresses Tumor Growth of Nonfunctioning Pituitary Adenomas by Targeting TPT1.	hsa_circ_0002316	circOMA1	hsa_circ_OMA1	OMA1	Nonfunctioning pituitary adenomas / NFPAs	MONDO:0019613	non-functioning pituitary adenoma	up-regulated	RT-qPCR	"circOMA1 is upregulated in NFPAs, especially invasive tumors. It promotes NFPA cell proliferation, invasion and xenograft tumor growth by sponging miR-145-5p, thereby increasing TPT1 and downstream anti-apoptotic signaling."	0.8174
30721952	The Journal of clinical endocrinology and metabolism	2019	circOMA1-Mediated miR-145-5p Suppresses Tumor Growth of Nonfunctioning Pituitary Adenomas by Targeting TPT1.	hsa_circ_0000835				Nonfunctioning pituitary adenomas / NFPAs	MONDO:0019613	non-functioning pituitary adenoma	up-regulated	RT-qPCR	hsa_circ_0000835 was identified as a predicted miR-145-5p-binding circRNA candidate and was significantly upregulated in NFPA tissues versus normal pituitary tissues. The study did not report a specific validated functional mechanism for this circRNA.	0.348
30721952	The Journal of clinical endocrinology and metabolism	2019	circOMA1-Mediated miR-145-5p Suppresses Tumor Growth of Nonfunctioning Pituitary Adenomas by Targeting TPT1.	hsa_circ_0000825				Nonfunctioning pituitary adenomas / NFPAs	MONDO:0019613	non-functioning pituitary adenoma	up-regulated	RT-qPCR	hsa_circ_0000825 was identified as a predicted miR-145-5p-binding circRNA candidate and was significantly upregulated in NFPA tissues versus normal pituitary tissues. The study did not report a specific validated functional mechanism for this circRNA.	0.348
30721952	The Journal of clinical endocrinology and metabolism	2019	circOMA1-Mediated miR-145-5p Suppresses Tumor Growth of Nonfunctioning Pituitary Adenomas by Targeting TPT1.	hsa_circ_0000994				Nonfunctioning pituitary adenomas / NFPAs	MONDO:0019613	non-functioning pituitary adenoma	up-regulated	RT-qPCR	hsa_circ_0000994 was identified as a predicted miR-145-5p-binding circRNA candidate and was significantly upregulated in NFPA tissues versus normal pituitary tissues. The study did not report a specific validated functional mechanism for this circRNA.	0.348
30722989	Biochemical and biophysical research communications	2019	Circular RNA circ-RAD23B promotes cell growth and invasion by miR-593-3p/CCND2 and miR-653-5p/TIAM1 pathways in non-small cell lung cancer.	hsa_circ_0087862	circ-RAD23B	hsa_circ_RAD23B	RAD23B	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ-RAD23B is up-regulated in NSCLC tissues and cell lines and high expression is associated with lymph node invasion, lower differentiation grade and shorter overall survival. Functionally, it promotes NSCLC cell growth, migration and invasion while suppressing apoptosis. Mechanistically, it sponges miR-593e3p and miR-653e5p to increase CCND2 and TIAM1 expression, supporting its potential as a prognostic biomarker and therapeutic target."	0.7408
30723269	Cancer gene therapy	2020	The circINTS4/miR-146b/CARMA3 axis promotes tumorigenesis in bladder cancer.	hsa_circ_0002476	circINTS4 / circRNA-INTS4	hsa_circ_INTS4	INTS4	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circINTS4 is upregulated in bladder cancer tissues and cell lines and functions as an oncogenic circRNA. It sponges miR-146b to upregulate CARMA3, thereby activating NF-kB signaling and suppressing P38 MAPK signaling, which promotes proliferation, migration, invasion, cell cycle progression and in vivo tumor formation while inhibiting apoptosis. The circINTS4/miR-146b/CARMA3 axis is proposed as a potential therapeutic target for bladder cancer."	0.8322
30735634	Cell	2019	Widespread and Functional RNA Circularization in Localized Prostate Cancer.		circCSNK1G3	hsa_circ_CSNK1G3	CSNK1G3	prostate cancer / PCa	MONDO:0008315	prostate cancer	unknown	RT-qPCR; RNA-seq	"circCSNK1G3 is a human circRNA derived from CSNK1G3 that is essential for proliferation of prostate cancer cell lines. It mainly localizes in the cytoplasm and promotes cell proliferation at least partly through interaction with miR-181b/d, affecting CBX7 and cell-cycle genes such as CDK1 and CDC25A."	0.7254
30735634	Cell	2019	Widespread and Functional RNA Circularization in Localized Prostate Cancer.		circGOLPH3	hsa_circ_GOLPH3	GOLPH3	prostate cancer / PCa	MONDO:0008315	prostate cancer	unknown	RT-qPCR; RNA-seq	"circGOLPH3 was one of the functionally evaluated essential circRNAs in prostate cancer cell lines. Knockdown and overexpression experiments, including RNA-seq-based transcriptomic analysis, suggested circGOLPH3 contributes to proliferation-related phenotypes independently of off-target effects."	0.6149
30735634	Cell	2019	Widespread and Functional RNA Circularization in Localized Prostate Cancer.		circSTAU2	hsa_circ_STAU2	STAU2	prostate cancer / PCa	MONDO:0008315	prostate cancer	unknown	RT-qPCR; RNA-seq	"circSTAU2 was one of the functionally evaluated essential circRNAs in prostate cancer cell lines. Knockdown and overexpression experiments, including RNA-seq-based transcriptomic analysis, suggested circSTAU2 contributes to proliferation-related phenotypes independently of off-target effects."	0.6149
30737027	Biochemical and biophysical research communications	2019	Enhanced expression of circ_0000735 forecasts clinical severity in NSCLC and promotes cell progression via sponging miR-1179 and miR-1182.	hsa_circ_0000735	circ_0000735			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0000735 is up-regulated in NSCLC tissues and cell lines, and its higher expression is associated with advanced TNM stage and lymph node metastasis. Functionally, it promotes NSCLC cell proliferation, colony formation, migration and invasion and suppresses apoptosis. Mechanistically, circ_0000735 acts as a sponge for miR-1179 and miR-1182, although downstream regulators were not identified."	0.6521
30738578	Biochemical and biophysical research communications	2019	Upregulated circular RNA circ_0074027 promotes glioblastoma cell growth and invasion by regulating miR-518a-5p/IL17RD signaling pathway.	hsa_circ_0074027	circ_0074027			glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR	"circ_0074027 is upregulated in GBM tissues and cell lines and is associated with larger tumor size and advanced WHO grade. Functionally, it promotes GBM cell growth, migration, and invasion while inhibiting apoptosis. Mechanistically, circ_0074027 sponges miR-518a-5p to increase IL17RD expression, forming a circ_0074027/miR-518a-5p/IL17RD oncogenic axis."	0.6536
30745107	Biochemical and biophysical research communications	2019	CircRNA hsa-circ-0014359 promotes glioma progression by regulating miR-153/PI3K signaling.	hsa_circ_0014359	circ-0014359			glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; ISH	"hsa-circ-0014359/circ-0014359 is up-regulated in glioma tissues and T98G/SHG44 glioma cells and is mainly localized in the cytoplasm. The study supports an oncogenic role in glioma, where circ-0014359 promotes cell viability, migration, invasion, and tumor growth by sponging miR-153 and activating PI3K/Akt signaling. Its high expression is associated with higher tumor grade and poor prognosis, suggesting potential therapeutic relevance."	0.742
30781971	Biomarkers in medicine	2019	hsa_circRNA_104597: a novel potential diagnostic and therapeutic biomarker for schizophrenia.		hsa_circRNA_101836			schizophrenia / SZ	MONDO:0005090	schizophrenia	down-regulated	RT-qPCR; Microarray	hsa circRNA 101836 was significantly downregulated in PBMCs from individuals with schizophrenia compared with healthy controls. It was one of three circRNAs showing diagnostic value by ROC analysis.	0.4679
30781971	Biomarkers in medicine	2019	hsa_circRNA_104597: a novel potential diagnostic and therapeutic biomarker for schizophrenia.		hsa_circRNA_102101			schizophrenia / SZ	MONDO:0005090	schizophrenia	down-regulated	RT-qPCR; Microarray	hsa circRNA 102101 was significantly downregulated in PBMCs from individuals with schizophrenia compared with healthy controls. It was one of three circRNAs showing diagnostic value by ROC analysis.	0.4679
30781971	Biomarkers in medicine	2019	hsa_circRNA_104597: a novel potential diagnostic and therapeutic biomarker for schizophrenia.		hsa_circRNA_104597			schizophrenia / SZ	MONDO:0005090	schizophrenia	down-regulated	RT-qPCR; Microarray	"hsa circRNA 104597 was significantly downregulated in PBMCs from individuals with schizophrenia and was significantly upregulated after 8 weeks of olanzapine treatment. It showed strong diagnostic performance and was proposed as a potential diagnostic and therapeutic biomarker for schizophrenia; five miRNA binding sites were predicted, but the mechanism was not experimentally established."	0.5047
30781971	Biomarkers in medicine	2019	hsa_circRNA_104597: a novel potential diagnostic and therapeutic biomarker for schizophrenia.		hsa_circRNA_103704			schizophrenia / SZ	MONDO:0005090	schizophrenia	up-regulated	RT-qPCR; Microarray	hsa circRNA 103704 was significantly upregulated in PBMCs from individuals with schizophrenia compared with healthy controls. It was included among five RT-qPCR-confirmed circRNAs proposed as potential biomarkers for schizophrenia.	0.3588
30781971	Biomarkers in medicine	2019	hsa_circRNA_104597: a novel potential diagnostic and therapeutic biomarker for schizophrenia.		hsa_circRNA_103102			schizophrenia / SZ	MONDO:0005090	schizophrenia	up-regulated	RT-qPCR; Microarray	hsa circRNA 103102 was significantly upregulated in PBMCs from individuals with schizophrenia compared with healthy controls. It was included among five RT-qPCR-confirmed circRNAs proposed as potential biomarkers for schizophrenia.	0.3588
30797148	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2019	Circular RNA circVAPA is up-regulated and exerts oncogenic properties by sponging miR-101 in colorectal cancer.	hsa_circ_0006990	circVAPA	hsa_circ_VAPA	VAPA	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"circVAPA (hsa_circ_0006990), derived from VAPA, is up-regulated in CRC tissues and plasma. It promotes malignant phenotypes of CRC cells by enhancing proliferation, migration and invasion while inhibiting apoptosis, at least partly through sponging miR-101. Plasma circVAPA shows diagnostic potential for CRC and its high level is associated with unfavorable clinicopathologic features."	0.8448
30810051	Epigenomics	2018	Circular RNA profile of breast cancer brain metastasis: identification of potential biomarkers and therapeutic targets.	hsa_circ_0001944				breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	"hsa circ 0001944 is upregulated in breast cancer brain metastasis cells and was validated by RNA-seq, RT-qPCR, and agarose gel electrophoresis. The study suggests it may act as a miRNA sponge for miR-509 and potentially contribute to BCBM, with possible diagnostic and therapeutic relevance."	0.5909
30810051	Epigenomics	2018	Circular RNA profile of breast cancer brain metastasis: identification of potential biomarkers and therapeutic targets.	hsa_circ_0001481				breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	hsa circ 0001481 is significantly upregulated in breast cancer brain metastasis cells and was validated by RNA-seq and RT-qPCR. The paper does not provide a specific downstream mechanism for this circRNA.	0.5909
30810051	Epigenomics	2018	Circular RNA profile of breast cancer brain metastasis: identification of potential biomarkers and therapeutic targets.	hsa_circ_0000646				breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	hsa circ 0000646 is significantly upregulated in breast cancer brain metastasis cells and was validated by RNA-seq and RT-qPCR. No specific downstream mechanism was established in this study.	0.5909
30810051	Epigenomics	2018	Circular RNA profile of breast cancer brain metastasis: identification of potential biomarkers and therapeutic targets.	hsa_circ_0001006				breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	hsa circ 0001006 is significantly upregulated in breast cancer brain metastasis cells and was validated by RNA-seq and RT-qPCR. No specific downstream mechanism was established in this study.	0.5909
30810051	Epigenomics	2018	Circular RNA profile of breast cancer brain metastasis: identification of potential biomarkers and therapeutic targets.	hsa_circ_0000732				breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	hsa circ 0000732 is significantly upregulated in breast cancer brain metastasis cells and was validated by RNA-seq and RT-qPCR. No specific downstream mechanism was established in this study.	0.5909
30824182	Biochemical and biophysical research communications	2019	Circ_0075932 in adipocyte-derived exosomes induces inflammation and apoptosis in human dermal keratinocytes by directly binding with PUM2 and promoting PUM2-mediated activation of AuroraA/NF-kappaB pathway.	hsa_circ_0075932				skin inflammation	MONDO:0002406	dermatitis	up-regulated	RT-qPCR	"circ_0075932 is an exosomal circRNA enriched in adipose tissue and upregulated in burned skin of obese patients. It promotes inflammation and apoptosis in dermal keratinocytes by binding PUM2 and activating the AuroraA/NF-kappaB pathway, suggesting a role in delayed wound healing in obesity."	0.6253
30826420	Toxicology letters	2019	"The emerging roles of a novel CCCH-type zinc finger protein, ZC3H4, in silica-induced epithelial to mesenchymal transition."		circZC3H4	mmu_circ_zc3h4	zc3h4	silicosis	MONDO:0005960	silicosis	up-regulated	RT-qPCR; ISH; Microarray	"circZC3H4 is up-regulated in silica-exposed lung epithelial cells and murine lung fibrosis tissue. It functions as a cytoplasmic miR-212 sponge to regulate ZC3H4 protein expression, thereby promoting SiO2-induced EMT and cell migration in silicosis-related pulmonary fibrosis."	0.683
30841415	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2019	Circular RNA circ_0002138 is down-regulated and suppresses cell proliferation in colorectal cancer.	hsa_circ_0002138	circ_0002138	hsa_circ_USP3	USP3	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"circ_0002138/hsa_circ_0002138 is a human USP3-derived circRNA that is significantly down-regulated in colorectal cancer tissues. It preferentially localizes in the cytoplasm, is resistant to RNase R, and suppresses CRC cell proliferation in vitro. Its expression shows diagnostic potential for distinguishing CRC tissues from adjacent normal tissues, but the exact molecular regulatory axis remains unresolved."	0.8294
30841451	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2019	CircRNA has_circ_0001946 promotes cell growth in lung adenocarcinoma by regulating miR-135a-5p/SIRT1 axis and activating Wnt/beta-catenin signaling pathway.	hsa_circ_0001946	circ_0001946			lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circ_0001946 is upregulated in lung adenocarcinoma tissues and cell lines, and high expression is associated with advanced TNM stage, larger tumor size and poor overall survival. Functionally, circ_0001946 promotes LAC cell proliferation and tumor growth while inhibiting apoptosis. Mechanistically, cytoplasmic circ_0001946 sponges miR-135a-5p to upregulate SIRT1 and activate Wnt/beta-catenin signaling."	0.866
30853176	Biochemical and biophysical research communications	2019	Elevation of circular RNA circ_0003645 forecasts unfavorable prognosis and facilitates cell progression via miR-1179/TMEM14A pathway in non-small cell lung cancer.	hsa_circ_0003645	circ_0003645			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0003645 is up-regulated in NSCLC tissues and cell lines, and high expression predicts unfavorable prognosis. Functionally, it acts as an oncogenic circRNA that promotes proliferation, migration and invasion while inhibiting apoptosis. Mechanistically, circ_0003645 sponges miR-1179 to elevate TMEM14A expression, forming a circ_0003645/miR-1179/TMEM14A regulatory axis."	0.7408
30853179	Biochemical and biophysical research communications	2019	Circular IRE-type RNAs of the NR5A1 gene are formed in adrenocortical cells.		circIRE NR5A1 ex6-1 RNA	hsa_circ_NR5A1	NR5A1	adrenocortical cancer	MONDO:0006639	adrenal cortex carcinoma	down-regulated	RT-qPCR	"circIRE NR5A1 ex6-1 RNA is an atypical NR5A1-derived circular RNA detected in normal human adrenal cortex but absent in the H295R adrenocortical cancer cell line. It is formed by ligation of IRE1a cleavage sites between exon 6 and exon 1, suggesting involvement of IRE1a-related ER stress processing and possible impairment of this circular RNA formation in adrenocortical cancer cells."	0.385
30853179	Biochemical and biophysical research communications	2019	Circular IRE-type RNAs of the NR5A1 gene are formed in adrenocortical cells.		circIRE NR5A1 ex7-1 RNA	hsa_circ_NR5A1	NR5A1	adrenocortical cancer	MONDO:0006639	adrenal cortex carcinoma	unknown	RT-qPCR	"circIRE NR5A1 ex7-1 RNA is an NR5A1-derived atypical circular RNA detected in H295R adrenocortical cancer cells after IRE1a overexpression. Its formation connects IRE1 cleavage sites in exon 7 and exon 1 and is suppressed by an IRE1 inhibitor, supporting an IRE1a/ER stress-dependent mechanism."	0.4844
30853181	Biochemical and biophysical research communications	2019	Upregulation of circular RNA circ-ERBB2 predicts unfavorable prognosis and facilitates the progression of gastric cancer via miR-503/CACUL1 and miR-637/MMP-19 signaling.		circ-ERBB2	hsa_circ_ERBB2	ERBB2	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ-ERBB2 is up-regulated in gastric cancer tissues and cell lines, and high expression is associated with aggressive clinicopathological features and poor overall survival. Functionally, circ-ERBB2 promotes gastric cancer cell proliferation, migration and invasion and suppresses apoptosis. Mechanistically, it acts as a miRNA sponge for miR-503 and miR-637 to regulate CACUL1 and MMP-19 signaling."	0.7408
30853185	Biochemical and biophysical research communications	2019	Circular RNA hsa_circ_0001368 suppresses the progression of gastric cancer by regulating miR-6506-5p/FOXO3 axis.	hsa_circ_0001368		hsa_circ_KLHL24	KLHL24	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0001368 is down-regulated in gastric cancer tissues and cells, and low expression is associated with worse patient prognosis. Functionally, hsa_circ_0001368 suppresses GC proliferation, invasion, migration, and tumor growth. Mechanistically, it acts as a ceRNA sponge for miR-6506e5p/miR-6506-5p to upregulate FOXO3, forming a hsa_circ_0001368/miR-6506e5p/FOXO3 tumor-suppressive axis."	0.8244
30864145	Journal of cellular physiology	2019	Downregulation of circDYNC1H1 exhibits inhibitor effect on cell proliferation and migration in hepatocellular carcinoma through miR-140-5p.	hsa_circ_0033351	circDYNC1H1	hsa_circ_DYNC1H1	DYNC1H1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circDYNC1H1 is upregulated in HCC tissues and cell lines. It promotes HCC cell proliferation, migration and tumor growth by sponging miR-140-5p and increasing SULT2B1 expression, suggesting potential biomarker and therapeutic-target value."	0.7032
30867795	Oncology letters	2019	circLPAR1 is a novel biomarker of prognosis for muscle-invasive bladder cancer with invasion and metastasis by miR-762.	hsa_circ_0087960	circ lysophosphatidic acid receptor 1	hsa_circ_LPAR1	LPAR1	bladder cancer	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR	"circLPAR1/hsa_circ_0087960 is a human LPAR1-derived circRNA down-regulated in MIBC tissues. Higher circLPAR1 expression is associated with better disease-specific survival, while knockdown enhances bladder cancer cell invasion and migration. Mechanistically, circLPAR1 binds miR-762 and inhibits its activity, suggesting a tumor-suppressive miRNA-sponge role in invasion and metastasis."	0.8267
30871426	Lupus	2019	RNA-seq of circular RNAs identified circPTPN22 as a potential new activity indicator in systemic lupus erythematosus.		circPTPN22	hsa_circ_PTPN22	PTPN22	systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	down-regulated	RT-qPCR; RNA-seq	"circPTPN22 is a previously undescribed human circRNA derived from PTPN22 and is down-regulated in PBMCs from patients with SLE. Its expression is negatively associated with SLE disease activity, increases after hormone treatment, and shows diagnostic potential; bioinformatics suggests a circPTPN22-miRNA-mRNA immune regulatory network."	0.5963
30871426	Lupus	2019	RNA-seq of circular RNAs identified circPTPN22 as a potential new activity indicator in systemic lupus erythematosus.		circLRRK2	hsa_circ_LRRK2		systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	up-regulated	RT-qPCR; RNA-seq	"circLRRK2 was identified as an up-regulated candidate circRNA in PBMCs from patients with SLE and its expression pattern was verified by qRT-PCR. The paper did not further characterize its mechanism, clinical utility, or functional role."	0.3588
30871426	Lupus	2019	RNA-seq of circular RNAs identified circPTPN22 as a potential new activity indicator in systemic lupus erythematosus.		circPPHLN1	hsa_circ_PPHLN1		systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	up-regulated	RT-qPCR; RNA-seq	"circPPHLN1 was identified as an up-regulated candidate circRNA in PBMCs from patients with SLE and its expression pattern was verified by qRT-PCR. The paper did not further characterize its mechanism, clinical utility, or functional role."	0.3588
30871426	Lupus	2019	RNA-seq of circular RNAs identified circPTPN22 as a potential new activity indicator in systemic lupus erythematosus.		circMYBL1	hsa_circ_MYBL1		systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	down-regulated	RT-qPCR; RNA-seq	"circMYBL1 was identified as a down-regulated candidate circRNA in PBMCs from patients with SLE and its expression pattern was verified by qRT-PCR. The paper did not further characterize its mechanism, clinical utility, or functional role."	0.3588
30873868	"Artificial cells, nanomedicine, and biotechnology"	2019	"A novel circular RNA, hsa_circ_0043278, acts as a potential biomarker and promotes non-small cell lung cancer cell proliferation and migration by regulating miR-520f."	hsa_circ_0043278	circ_0043278 / hsa_102049	hsa_circ_TADA2A	TADA2A	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0043278/circ_0043278 is up-regulated in NSCLC tissues and cell lines and is associated with metastasis-related clinicopathologic features. Functionally, it promotes NSCLC proliferation, invasion, migration, tumor sphere formation, and xenograft tumor growth. Mechanistically, circ_0043278 sponges miR-520f to increase ROCK1, CDKN1B, and AKT3 expression, suggesting potential biomarker and therapeutic relevance."	0.7295
30876857	Journal of molecular and cellular cardiology	2019	Circular RNA Ttc3 regulates cardiac function after myocardial infarction by sponging miR-15b.		circ-Ttc3	rno_circ_Ttc3		myocardial infarction / MI	MONDO:0005068	myocardial infarction	up-regulated	RT-qPCR	"circ-Ttc3 is up-regulated in ischemic myocardium and hypoxia-treated cardiomyocytes and functions as a cardioprotective circRNA in myocardial infarction. It sponges miR-15b/miR-15b-5p to increase Arl2 expression, thereby reducing hypoxia/ischemia-induced ATP depletion and cardiomyocyte apoptosis; circ-Ttc3 knockdown worsens post-MI cardiac dysfunction and remodeling."	0.7785
30887246	Neuroscience bulletin	2019	Circular HDAC9/microRNA-138/Sirtuin-1 Pathway Mediates Synaptic and Amyloid Precursor Protein Processing Deficits in Alzheimer's Disease.	hsa_circ_0003594	circRNA HDAC9 / CircHDAC9	hsa_circ_HDAC9	HDAC9	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR; ISH	"CircHDAC9 is down-regulated in Abeta-treated N2a cells, 4-month-old APP/PS1 mice, and serum from MCI and AD patients. It acts as a cytoplasmic miR-138 sponge in the circHDAC9/miR-138/Sirt1 axis, restoring Sirt1 and ADAM10-related APP processing and reducing excessive Abeta production. The study proposes circHDAC9 as a potential early diagnostic marker and therapeutic target for Alzheimer's disease."	0.725
30887246	Neuroscience bulletin	2019	Circular HDAC9/microRNA-138/Sirtuin-1 Pathway Mediates Synaptic and Amyloid Precursor Protein Processing Deficits in Alzheimer's Disease.	mmu_circ_0003925	circRNA HDAC9 / CircHDAC9	mmu_circ_HDAC9	HDAC9	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR; ISH	"CircHDAC9 is down-regulated in Abeta-treated N2a cells, 4-month-old APP/PS1 mice, and serum from MCI and AD patients. It acts as a cytoplasmic miR-138 sponge in the circHDAC9/miR-138/Sirt1 axis, restoring Sirt1 and ADAM10-related APP processing and reducing excessive Abeta production. The study proposes circHDAC9 as a potential early diagnostic marker and therapeutic target for Alzheimer's disease."	0.725
30892069	Epigenomics	2019	Altered expression profile of circular RNAs in conjunctival melanoma.	hsa_circ_0083444	circMTUS1	hsa_circ_MTUS1	MTUS1	conjunctival melanoma	MONDO:0002096	malignant conjunctival melanoma	up-regulated	RT-qPCR; RNA-seq	"circMTUS1 is a human MTUS1-derived circRNA that is upregulated in conjunctival melanoma tissues and cell lines. Functional loss-of-function experiments showed that circMTUS1 promotes conjunctival melanoma proliferation and tumor growth in vitro and in vivo. Mechanistically, circMTUS1 may act as an Ago2-dependent miRNA sponge for hsa-miR-622 and hsa-miR-1208, thereby influencing tumor-associated pathways such as MAPK and Wnt signaling, and it may serve as a novel biomarker for conjunctival melanoma."	0.8376
30896837	Molecular medicine reports	2019	Circular RNA expression alterations in colon tissues of Crohn's disease patients.		hsa-circRNA-102685			Crohn's disease / CD	MONDO:0005011	Crohn disease	up-regulated	RT-qPCR; Microarray	"hsa-circRNA-102685 was up-regulated in colon tissues from Crohn's disease patients by both microarray and RT-qPCR. The study predicts that it may act as a miRNA sponge for hsa-miR-146b-5p, hsa-miR-182-5p and hsa-miR-146a-5p, forming a circRNA-miRNA-gene network involved in apoptosis, immune-related signaling and p53-related processes."	0.5135
30896837	Molecular medicine reports	2019	Circular RNA expression alterations in colon tissues of Crohn's disease patients.		hsa_circRNA_102774			Crohn's disease / CD	MONDO:0005011	Crohn disease	up-regulated	Microarray	"hsa_circRNA_102774 was identified by microarray as an up-regulated circRNA in Crohn's disease colon tissues. It was listed among differentially expressed circRNAs predicted to target miR-146, but it was not individually validated by RT-qPCR in this study."	0.348
30896837	Molecular medicine reports	2019	Circular RNA expression alterations in colon tissues of Crohn's disease patients.		hsa_circRNA_101753			Crohn's disease / CD	MONDO:0005011	Crohn disease	up-regulated	Microarray	"hsa_circRNA_101753 was identified by microarray as an up-regulated circRNA in Crohn's disease colon tissues. It was included among putative miR-146-targeting circRNAs, but no individual RT-qPCR validation or functional assays were reported for this circRNA."	0.348
30896837	Molecular medicine reports	2019	Circular RNA expression alterations in colon tissues of Crohn's disease patients.		hsa_circRNA_102261			Crohn's disease / CD	MONDO:0005011	Crohn disease	up-regulated	Microarray	"hsa_circRNA_102261 was identified by microarray as an up-regulated circRNA in Crohn's disease colon tissues. It was predicted to target miR-146, but was not selected for further RT-qPCR validation or mechanistic analysis."	0.348
30896837	Molecular medicine reports	2019	Circular RNA expression alterations in colon tissues of Crohn's disease patients.		hsa_circRNA_101598			Crohn's disease / CD	MONDO:0005011	Crohn disease	down-regulated	Microarray	"hsa_circRNA_101598 was identified by microarray as a down-regulated circRNA in Crohn's disease colon tissues. It was predicted to target miR-146, but was not individually validated by RT-qPCR or further functionally characterized."	0.348
30896837	Molecular medicine reports	2019	Circular RNA expression alterations in colon tissues of Crohn's disease patients.		hsa_circRNA_101863			Crohn's disease / CD	MONDO:0005011	Crohn disease	down-regulated	Microarray	"hsa_circRNA_101863 was identified by microarray as a down-regulated circRNA in Crohn's disease colon tissues. It was predicted to target miR-146, but no RT-qPCR validation or specific downstream pathway analysis was reported for this circRNA."	0.348
30896837	Molecular medicine reports	2019	Circular RNA expression alterations in colon tissues of Crohn's disease patients.		hsa_circRNA_100189			Crohn's disease / CD	MONDO:0005011	Crohn disease	down-regulated	Microarray	"hsa_circRNA_100189 was identified by microarray as a down-regulated circRNA in Crohn's disease colon tissues. It was included among putative miR-146-targeting circRNAs, but no RT-qPCR validation or detailed mechanistic experiments were reported for this circRNA."	0.348
30898507	Hepatobiliary & pancreatic diseases international : HBPD INT	2019	Circular RNA ciRS-7 promotes the proliferation and metastasis of pancreatic cancer by regulating miR-7-mediated EGFR/STAT3 signaling pathway.		ciRS-7			pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR	"ciRS-7 is up-regulated in PDAC tissues and pancreatic cancer cell lines. It functions as an oncogenic circRNA by inhibiting miR-7 activity and regulating EGFR/STAT3 signaling, thereby promoting proliferation and invasion. Clinically, higher ciRS-7 expression is associated with venous invasion and lymph node metastasis."	0.568
30898701	Gene	2019	Expression patterns of novel circular RNAs in chicken cells after avian leukosis virus subgroup J infection.		circRNA7419	gga_circ_KDM4C	KDM4C	ALV-J infection	MONDO:0005108	viral infectious disease	up-regulated	RNA-seq	"circRNA7419 was up-regulated over the ALV-J infection time course in CEF cells. Its host gene KDM4C was linked to immune-related epigenetic regulation and activated B-cell proliferation, suggesting a possible role in the immune response to ALV-J infection."	0.2414
30898701	Gene	2019	Expression patterns of novel circular RNAs in chicken cells after avian leukosis virus subgroup J infection.		circRNA6679	gga_circ_TNFAIP6	TNFAIP6	ALV-J infection	MONDO:0005108	viral infectious disease	down-regulated	RNA-seq	"circRNA6679 was down-regulated during ALV-J infection in CEF cells. It is associated with the host gene TNFAIP6, which the authors linked to inflammation, anti-inflammatory activity, tissue protection, and immune response regulation."	0.2414
30898701	Gene	2019	Expression patterns of novel circular RNAs in chicken cells after avian leukosis virus subgroup J infection.		circRNA6680	gga_circ_TNFAIP6	TNFAIP6	ALV-J infection	MONDO:0005108	viral infectious disease	down-regulated	RNA-seq	"circRNA6680 was down-regulated during ALV-J infection in CEF cells. It is associated with the host gene TNFAIP6, suggesting possible involvement in inflammatory and immune-response regulation during infection."	0.2414
30903189	Toxicological sciences : an official journal of the Society of Toxicology	2019	Circular RNA 0039411 Is Involved in Neodymium Oxide-induced Inflammation and Antiproliferation in a Human Bronchial Epithelial Cell Line via Sponging miR-93-5p.	hsa_circ_0039411	circRNA 0039411	hsa_circ_MMP2	MMP2	Bronchial inflammation	MONDO:0003781	bronchitis	up-regulated	RT-qPCR; Microarray	"circ_0039411 is an MMP2-derived human circRNA upregulated in Nd 2 O 3-treated bronchial epithelial cells. It promotes inflammatory cytokine production and anti-proliferative effects by arresting cells at G0/G1, functioning as a miR-93-5p sponge that enhances STAT3 phosphorylation."	0.6941
30908647	Journal of cellular physiology	2019	Circular RNA expression profile in human fibroblast premature senescence after repeated ultraviolet B irradiations revealed by microarray.		hsa_circRNA_100797	hsa_circ_CD44	CD44	skin aging	MONDO:0005093	skin disorder	down-regulated	RT-qPCR; Microarray	"circRNA_100797 is down-regulated in UVB-SIPS human fibroblasts. Its overexpression protects against UVB-induced senescence by promoting cell proliferation, relieving G1 cell-cycle arrest, reducing p16/p21/p53 expression, and sponging miR-23a-5p."	0.6683
30908647	Journal of cellular physiology	2019	Circular RNA expression profile in human fibroblast premature senescence after repeated ultraviolet B irradiations revealed by microarray.		hsa_circRNA_100686			skin aging	MONDO:0005093	skin disorder	down-regulated	RT-qPCR; Microarray	hsa_circRNA_100686 was confirmed by qRT-PCR to be down-regulated in UVB-SIPS fibroblasts. The study mapped it for potential miRNA targeting but did not report circRNA-specific functional validation.	0.3858
30908647	Journal of cellular physiology	2019	Circular RNA expression profile in human fibroblast premature senescence after repeated ultraviolet B irradiations revealed by microarray.		hsa_circRNA_400036			skin aging	MONDO:0005093	skin disorder	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_400036 was confirmed by qRT-PCR to be up-regulated in UVB-SIPS fibroblasts. It was included in the circRNA-miRNA network analysis, but no circRNA-specific functional mechanism was experimentally validated."	0.3858
30908647	Journal of cellular physiology	2019	Circular RNA expression profile in human fibroblast premature senescence after repeated ultraviolet B irradiations revealed by microarray.		hsa_circRNA_101755			skin aging	MONDO:0005093	skin disorder	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_101755 was confirmed by qRT-PCR to be up-regulated in UVB-SIPS fibroblasts. It was mapped for potential miRNA interactions, but this study did not provide individual functional validation for it."	0.3858
30908647	Journal of cellular physiology	2019	Circular RNA expression profile in human fibroblast premature senescence after repeated ultraviolet B irradiations revealed by microarray.		hsa_circRNA_003794			skin aging	MONDO:0005093	skin disorder	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_003794 was confirmed by qRT-PCR to be up-regulated in UVB-SIPS fibroblasts. The study included it in potential circRNA-miRNA mapping, without reporting individual mechanistic or functional assays for this circRNA."	0.3858
30908839	Oral diseases	2019	Decreased expression of hsa_circ_0072387 as a valuable predictor for oral squamous cell carcinoma.	hsa_circ_0072387	circ_0072387	hsa_circ_HMGCS1	HMGCS1	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR	"hsa_circ_0072387 is significantly down-regulated in OSCC tissues and cell lines. Its lower expression is associated with more aggressive clinicopathological features and worse survival, while ROC analysis suggests diagnostic potential. Bioinformatics predicts a possible miRNA-mediated regulatory network involving hsa-miR-129-3p, hsa-miR-141-3p, hsa-miR-29-3p, and downstream targets such as MMP2, BCL2, and PTEN."	0.5339
30908929	American journal of respiratory cell and molecular biology	2019	CircRNA-012091/PPP1R13B-mediated Lung Fibrotic Response in Silicosis via Endoplasmic Reticulum Stress and Autophagy.		circ-012091	mmu_circ_ppp1r13b	ppp1r13b	silicosis	MONDO:0005960	silicosis	down-regulated	RT-qPCR; ISH; Microarray	"ciR-012091 is a mouse circRNA derived from the ppp1r13b host gene and is downregulated in SiO2-stimulated L929 fibroblasts and mouse silicosis lung tissue. Its decrease is linked to increased PPP1R13B protein expression, which activates endoplasmic reticulum stress and autophagy and promotes fibroblast proliferation and migration in silicosis fibrosis."	0.4957
30909190	Cancer biomarkers : section A of Disease markers	2019	Circ0001429 regulates progression of bladder cancer through binding miR-205-5p and promoting VEGFA expression.	hsa_circ_0001429				bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"Circ0001429 is up-regulated in bladder cancer tissues and cells. It promotes bladder cancer proliferation, migration, invasion, tumor growth and metastasis while inhibiting apoptosis, mainly by sponging miR-205-5p and increasing VEGFA expression/protein level. Its knockdown suppresses xenograft tumor growth and lung metastasis, suggesting potential therapeutic relevance."	0.7302
30917906	Experimental eye research	2019	Reduction of circular RNA expression associated with human retinoblastoma.	hsa_circ_0093996			TET1	retinoblastoma / RB	MONDO:0008380	retinoblastoma	down-regulated	RT-qPCR; RNA-seq	This circRNA is downregulated in primary and recurrent retinoblastoma tissues. The authors propose that it may contribute to RB pathogenesis through a predicted TET1-has_circ_0093996/miR-183/PDCD4 ceRNA axis and may also reflect chromatin-related epigenetic alterations. It is suggested as a potential prognostic and therapeutic candidate.	0.4993
30922709	Gene	2019	Circ-LAMP1 promotes T-cell lymphoblastic lymphoma progression via acting as a ceRNA for miR-615-5p to regulate DDR2 expression.		hsa_circRNA_101303	hsa_circ_LAMP1	LAMP1	T-cell lymphoblastic lymphoma / T-LBL	MONDO:0044917	T-lymphoblastic lymphoma	up-regulated	RT-qPCR; Microarray	"circ-LAMP1/hsa_circRNA_101303 is upregulated in T-LBL tissues and cell lines. It promotes T-LBL cell proliferation and inhibits apoptosis by acting as a ceRNA for miR-615-5p, thereby increasing DDR2 expression through the circ-LAMP1/miR-615-5p/DDR2 axis. The study suggests circ-LAMP1 may be an oncogenic therapeutic target in T-LBL, while its prognostic value was not investigated."	0.6777
30925324	International immunopharmacology	2019	"Role of the ciRS-7/miR-7 axis in the regulation of proliferation, apoptosis and inflammation of chondrocytes induced by IL-1beta."		ciRS-7 / Cdr1as	hsa_circ_CDR1AS		Osteoarthritis / OA	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR	"This study found that human ciRS-7 is down-regulated in blood/plasma from OA patients and in IL-1beta-induced chondrocytes. Functionally, ciRS-7 appears protective in OA model chondrocytes: knockdown promotes inflammatory cytokine release and apoptosis, whereas ciRS-7 overexpression suppresses Bax and cleaved caspase-9 and promotes Bcl-2. The proposed mechanism is regulation through the ciRS-7/miR-7 axis."	0.5414
30928094	Biochemical and biophysical research communications	2019	CircRNA_000543 knockdown sensitizes nasopharyngeal carcinoma to irradiation by targeting miR-9/platelet-derived growth factor receptor B axis.		circRNA_000543			nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; Microarray	"circRNA_000543 is up-regulated in NPC, especially in radioresistant NPC tissues and radioresistant NPC cell lines, and high expression predicts poorer overall survival. Functionally, circRNA_000543 supports radioresistance, proliferation and invasion while suppressing apoptosis. Mechanistically, circRNA_000543 acts through the miR-9/PDGFRB axis, and its knockdown sensitizes NPC cells to irradiation."	0.8135
30931701	"Cell cycle (Georgetown, Tex.)"	2019	"circ-BIRC6, a circular RNA, promotes hepatocellular carcinoma progression by targeting the miR-3918/Bcl2 axis."	hsa_circ_0003288	circ-BIRC6	hsa_circ_BIRC6	BIRC6	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ-BIRC6 is up-regulated in HCC tissues and cell lines and high expression predicts poor overall survival. Functionally, circ-BIRC6 promotes HCC proliferation, migration, invasion and xenograft tumor growth while inhibiting apoptosis. Mechanistically, it acts as a sponge for miR-3918 to increase Bcl2 mRNA and protein expression through the circ-BIRC6/miR-3918/Bcl2 axis."	0.8066
30938850	Journal of cellular biochemistry	2019	Upregulation of circular RNA circ_0034642 indicates unfavorable prognosis in glioma and facilitates cell proliferation and invasion via the miR-1205/BATF3 axis.	hsa_circ_0034642	circ_0034642			glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"hsa_circ_0034642 is up-regulated in glioma tissues and cell lines and its high expression predicts adverse prognosis. Functionally, it promotes glioma cell proliferation, colony formation, migration and invasion while suppressing apoptosis. Mechanistically, it acts through a miR-1205/BATF3 regulatory axis."	0.7408
30939216	International journal of cancer	2019	Circular RNA CEP128 promotes bladder cancer progression by regulating Mir-145-5p/Myd88 via MAPK signaling pathway.		circ-CEP128	hsa_circ_CEP128	CEP128	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"circCEP128 is upregulated in bladder cancer tissues, blood, and bladder cancer cells. It promotes bladder cancer progression by sponging miR-145-5p, increasing MYD88 and activating downstream MAPK signaling proteins; its knockdown suppresses proliferation, migration, cell cycle progression and xenograft tumor growth while increasing apoptosis."	0.8325
30941555	Archives of gynecology and obstetrics	2019	Novel circular RNA expression in the cumulus cells of patients with polycystic ovary syndrome.	hsa_circ_0043533				polycystic ovary syndrome / PCOS	MONDO:0008487	polycystic ovary syndrome	up-regulated	RT-qPCR; Microarray	"hsa_circ_0043533 was significantly upregulated in cumulus cells from PCOS patients and may act as a diagnostic biomarker. Bioinformatics suggested it may participate in PCOS-related steroidogenesis through a miRNA sponge mechanism, particularly via miR-132."	0.5047
30941555	Archives of gynecology and obstetrics	2019	Novel circular RNA expression in the cumulus cells of patients with polycystic ovary syndrome.	hsa_circ_0043532				polycystic ovary syndrome / PCOS	MONDO:0008487	polycystic ovary syndrome	up-regulated	RT-qPCR; Microarray	hsa_circ_0043532 was significantly upregulated in cumulus cells from PCOS patients and may serve as a diagnostic biomarker. The study suggests it may influence PCOS-related steroidogenesis through miRNA-132-associated circRNA-miRNA interactions.	0.5047
30941555	Archives of gynecology and obstetrics	2019	Novel circular RNA expression in the cumulus cells of patients with polycystic ovary syndrome.	hsa_circ_0097636				polycystic ovary syndrome / PCOS	MONDO:0008487	polycystic ovary syndrome	down-regulated	RT-qPCR; Microarray	"hsa_circ_0097636 was significantly downregulated in cumulus cells from PCOS patients and showed diagnostic potential, especially when combined with serum testosterone. It may participate in PCOS-related hyperfolliculogenesis and steroidogenesis via predicted interactions with miR-125b and miR-30c."	0.5047
30944081	Biochemical and biophysical research communications	2019	Hsa_circ_0001742 promotes tongue squamous cell carcinoma progression via modulating miR-634 expression.	hsa_circ_0001742	circ_0001742			tongue squamous cell carcinoma / TSCC	MONDO:0000500	tongue squamous cell carcinoma	up-regulated	RT-qPCR	"hsa_circ_0001742 is up-regulated in TSCC tissues and is associated with advanced clinical stage and lymph-node metastasis. Functionally, it promotes TSCC cell proliferation, invasion, and EMT. Mechanistically, it acts as a ceRNA by sponging miR-634 to regulate RAB1A expression."	0.6996
30945557	"Artificial cells, nanomedicine, and biotechnology"	2019	"Circular RNA (hsa_circ_0051240) promotes cell proliferation, migration and invasion in ovarian cancer through miR-637/KLK4 axis."	hsa_circ_0051240	circ_0051240 	hsa_circ_CEACAM5	CEACAM5	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0051240 is up-regulated in ovarian cancer tissues and cell lines and is associated with metastasis-related clinicopathologic features and poor survival. Functionally, it promotes OC proliferation, colony formation, migration, invasion, and xenograft tumour growth. Mechanistically, it acts as a ceRNA sponge for miR-637 to regulate KLK4 expression, forming the hsa_circ_0051240/miR-637/KLK4 axis."	0.8703
30954221	Biochemical and biophysical research communications	2019	Circular RNA circ-FOXM1 facilitates cell progression as ceRNA to target PPDPF and MACC1 by sponging miR-1304-5p in non-small cell lung cancer.	hsa_circ_0025033	Circ-FOXM1	hsa_circ_FOXM1	FOXM1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ-FOXM1 is up-regulated in NSCLC tissues and cell lines and is associated with advanced TNM stage, lymph node metastasis and poorer survival. Functionally, circ-FOXM1 promotes NSCLC cell proliferation, migration and invasion while suppressing apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-1304-5p to increase PPDPF and MACC1 expression."	0.7408
30955816	Veterinary microbiology	2019	Circular RNA GATAD2A promotes H1N1 replication through inhibiting autophagy.		circ-GATAD2A / hsa_circ_30753	hsa_circ_GATAD2A	GATAD2A	influenza A virus infection / IAV infection	MONDO:0005812	influenza	up-regulated	RT-qPCR	"circ-GATAD2A is induced by H1N1 infection in A549 cells. It promotes H1N1 replication by inhibiting autophagy, likely through a VPS34-dependent mechanism involving interaction with VPS34. The study suggests circ-GATAD2A may be a potential therapeutic target for influenza virus infection."	0.7076
30965236	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2019	"circ-CSPP1 promotes proliferation, invasion and migration of ovarian cancer cells by acting as a miR-1236-3p sponge."	hsa_circ_0001806	circ-CSPP1	hsa_circ_CSPP1	CSPP1	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; Microarray	"circ-CSPP1 (hsa_circ_0001806), derived from CSPP1, is up-regulated in ovarian cancer tissues and higher expression correlates with more advanced FIGO stage and poorer differentiation. Functionally, it promotes ovarian cancer cell growth, migration and invasion by sponging miR-1236-3p, relieving miR-1236-3p-mediated inhibition of ZEB1 and promoting EMT-related changes."	0.6815
30967263	Biochemical and biophysical research communications	2019	Upregulated circular RNA circ_0070934 facilitates cutaneous squamous cell carcinoma cell growth and invasion by sponging miR-1238 and miR-1247-5p.	hsa_circ_0070934	circ_0070934	hsa_circ_LARP1B	LARP1B	cutaneous squamous cell carcinoma / CSCC	MONDO:0002529	skin squamous cell carcinoma	up-regulated	RT-qPCR	"circ_0070934 is up-regulated in CSCC tissues and cell lines. It acts as an oncogenic circRNA that promotes proliferation, colony formation, migration and invasion while inhibiting apoptosis, at least partly by sponging and suppressing miR-1238 and miR-1247e5p. Higher circ_0070934 expression is associated with tumor aggressiveness and may represent a therapeutic target for CSCC."	0.6521
30967276	International journal of cardiology	2019	Inhibition of circHIPK3 prevents angiotensin II-induced cardiac fibrosis by sponging miR-29b-3p.	mmu_circ_0001052	circHIPK3	mmu_circ_HIPK3	HIPK3	cardiac fibrosis	MONDO:0005267	heart disorder	up-regulated	RT-qPCR; ISH	"In this study, mouse circHIPK3 is up-regulated in cardiac fibroblasts and heart tissues after Ang II treatment. circHIPK3 promotes cardiac fibroblast proliferation, migration and fibrotic marker expression by sponging miR-29b-3p and regulating COL1A1, COL3A1 and a-SMA; silencing circHIPK3 attenuates Ang II-induced cardiac fibrosis in vivo."	0.8415
30968727	"Artificial cells, nanomedicine, and biotechnology"	2019	CircCDYL inhibits the expression of C-MYC to suppress cell growth and migration in bladder cancer.		circCDYL	hsa_circ_CDYL	CDYL	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR	"circCDYL is down-regulated in bladder cancer tissues and cell lines and is mainly localized in the cytoplasm. Its over-expression suppresses bladder cancer cell proliferation and migration and induces G0/G1 cell cycle arrest, at least partly by reducing C-MYC protein levels. Lower circCDYL expression is associated with higher pathological stage, supporting a tumor-suppressive and potential therapeutic role."	0.7094
30970529	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2019	Circular RNA circ_0026134 regulates non-small cell lung cancer cell proliferation and invasion via sponging miR-1256 and miR-1287.	hsa_circ_0026134	circ_0026134	hsa_circ_TUBA1C	TUBA1C	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0026134 is upregulated in NSCLC and acts as an oncogenic circRNA. It promotes proliferation, migration, invasion and cell survival while inhibiting apoptosis, mainly by sponging miR-1256 and miR-1287 and thereby regulating downstream targets such as TCTN1 and GAGE1."	0.5554
30975029	Cancer biology & therapy	2019	A regulatory circuit of circ-MTO1/miR-17/QKI-5 inhibits the proliferation of lung adenocarcinoma.	hsa_circ_0007874	circ-MTO1	hsa_circ_MTO1	MTO1	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR	"circ-MTO1 is down-regulated in LUAD and functions as a tumor suppressor by inhibiting LUAD cell proliferation and xenograft tumor growth. Mechanistically, it sponges miR-17 to increase QKI-5 expression and inactivate Notch signaling, while QKI-5 can promote circ-MTO1 expression to form a feedback loop. Clinically, low circ-MTO1 expression is associated with advanced disease features and poorer overall and progression-free survival."	0.7878
30992382	"Clinical science (London, England : 1979)"	2019	CircRASSF2 promotes laryngeal squamous cell carcinoma progression by regulating the miR-302b-3p/IGF-1R axis.	hsa_circ_0059354	circ_0059354 / circRASSF2	hsa_circ_RASSF2	RASSF2	Laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circRASSF2 is up-regulated in LSCC tissues, cell lines and serum exosomes. It functions as an oncogenic ceRNA by sponging miR-302b-3p and regulating IGF-1R, thereby promoting proliferation, migration, invasion and xenograft tumor growth while inhibiting apoptosis. Clinically, high circRASSF2 expression is associated with metastasis, advanced T category and lymph node metastasis, and serum exosomal circRASSF2 may have diagnostic biomarker potential."	0.8174
30993801	Journal of cellular biochemistry	2019	Upregulation of hsa_circ_0136666 contributes to breast cancer progression by sponging miR-1299 and targeting CDK6.	hsa_circ_0136666	circ_0136666			breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"hsa_circ_0136666 is up-regulated in breast cancer cells and tissues. It promotes breast cancer progression by enhancing proliferation, cell-cycle progression, migration and invasion, at least partly through sponging miR-1299 and positively regulating CDK6 expression. The authors propose the hsa_circ_0136666/miR-1299/CDK6 axis as a potential biomarker and therapeutic target for breast cancer."	0.7045
31001629	Carcinogenesis	2019	circRAD18 sponges miR-208a/3164 to promote triple-negative breast cancer progression through regulating IGF1 and FGF2 expression.	hsa_circ_0002453	circRAD18	hsa_circ_RAD18	RAD18	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; Microarray	"circRAD18 (hsa_circ_0002453), derived from RAD18, is up-regulated in TNBC tissues and cell lines and is associated with advanced clinicopathologic features and poorer overall survival. Functionally, circRAD18 promotes proliferation, migration, tumor growth and metastasis while suppressing apoptosis. Mechanistically, it acts as a ceRNA sponge for miR-208a and miR-3164, thereby increasing IGF1 and FGF2 expression."	0.8673
31004447	"Hepatology (Baltimore, Md.)"	2019	Circular RNA MAT2B Promotes Glycolysis and Malignancy of Hepatocellular Carcinoma Through the miR-338-3p/PKM2 Axis Under Hypoxic Stress.	hsa_circ_0074854	circular RNA MAT2B / circMAT2B	hsa_circ_MAT2B	MAT2B	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circMAT2B is up-regulated in HCC tissues and cell lines and high expression predicts poor overall survival. It promotes glycolysis, tumor growth, migration, invasion and metastasis under hypoxia by sponging miR-338-3p and up-regulating PKM2, suggesting therapeutic potential in HCC."	0.8981
31004447	"Hepatology (Baltimore, Md.)"	2019	Circular RNA MAT2B Promotes Glycolysis and Malignancy of Hepatocellular Carcinoma Through the miR-338-3p/PKM2 Axis Under Hypoxic Stress.	hsa_circ_0006461	circKDM4B	hsa_circ_KDM4B	KDM4B	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circKDM4B was identified from GEO microarray datasets and validated by RT-qPCR as significantly increased in HCC tissues versus adjacent nontumor tissues. The study did not further characterize its function, mechanism, localization, or clinical prognostic value."	0.4032
31004447	"Hepatology (Baltimore, Md.)"	2019	Circular RNA MAT2B Promotes Glycolysis and Malignancy of Hepatocellular Carcinoma Through the miR-338-3p/PKM2 Axis Under Hypoxic Stress.	hsa_circ_0008514	circRT-N4IP1	hsa_circ_RT-N4IP1	RT-N4IP1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circRT-N4IP1 was identified from GEO microarray datasets and validated by RT-qPCR as significantly increased in HCC tissues versus adjacent nontumor tissues. The study did not further characterize its function, mechanism, localization, or clinical prognostic value."	0.4032
31005252	Biochemical and biophysical research communications	2019	The circRNA circP4HB promotes NSCLC aggressiveness and metastasis by sponging miR-133a-5p.	hsa_circ_0046263	hsa_circRNA_102231 / circP4HB	hsa_circ_P4HB	P4HB	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Northern Blot	"circP4HB is up-regulated in NSCLC tissues and cell lines and high expression is linked to lymph node metastasis and poorer survival. Functionally, it promotes NSCLC cell migration, invasion, EMT, and metastatic lung tumor burden by sponging miR-133a-5p and increasing vimentin expression."	0.8686
31019161	Bioscience trends	2019	Circular RNA profiling reveals circRNA1656 as a novel biomarker in high grade serous ovarian cancer.		circRNA385	hsa_circ_HIPK3	HIPK3	ovarian cancer / OC	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR; RNA-seq	"circRNA385 was identified by circRNA high-throughput sequencing and validated by qRT-PCR as down-regulated in HGSOC tissues. The authors proposed it as a potential tumor marker, although no individual mechanism was reported."	0.429
31019161	Bioscience trends	2019	Circular RNA profiling reveals circRNA1656 as a novel biomarker in high grade serous ovarian cancer.		circRNA2058	hsa_circ_RHOBTB3	RHOBTB3	ovarian cancer / OC	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR; RNA-seq	"circRNA2058 was identified and qRT-PCR-validated as down-regulated in HGSOC tissues. It was proposed as a potential tumor marker, with no individual downstream mechanism demonstrated."	0.429
31019161	Bioscience trends	2019	Circular RNA profiling reveals circRNA1656 as a novel biomarker in high grade serous ovarian cancer.		circRNA3336	hsa_circ_BNC2	BNC2	ovarian cancer / OC	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR; RNA-seq	"circRNA3336 was validated as down-regulated in HGSOC tissues, consistent with circRNA sequencing. The study suggested it may have tumor-marker potential, but did not define a circRNA3336-specific mechanism."	0.429
31019161	Bioscience trends	2019	Circular RNA profiling reveals circRNA1656 as a novel biomarker in high grade serous ovarian cancer.		circRNA2606	hsa_circ_LRCH3	LRCH3	ovarian cancer / OC	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR; RNA-seq	"circRNA2606 was confirmed by qRT-PCR as down-regulated in HGSOC tissues, matching sequencing results. The study suggested potential tumor-marker value but did not report a specific molecular mechanism."	0.429
31019161	Bioscience trends	2019	Circular RNA profiling reveals circRNA1656 as a novel biomarker in high grade serous ovarian cancer.	hsa_circ_0002755	circRNA1656	hsa_circ_CLIP2	CLIP2	ovarian cancer / OC	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR; RNA-seq	"circRNA1656 was the main candidate biomarker in this study and was consistently down-regulated in HGSOC tissues and ovarian cancer cell lines. Its expression was associated with FIGO stage, and bioinformatic analyses suggested possible involvement in a circRNA-miRNA network and inhibition of PIG-U/GPI-anchor biosynthesis."	0.4685
31019161	Bioscience trends	2019	Circular RNA profiling reveals circRNA1656 as a novel biomarker in high grade serous ovarian cancer.		circRNA1312	hsa_circ_ZNY208	ZNY208	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; RNA-seq	"circRNA1312 was identified and validated as up-regulated in HGSOC tissues. The authors suggested possible tumor-marker potential, but no circRNA1312-specific mechanism or functional assay was reported."	0.429
31019161	Bioscience trends	2019	Circular RNA profiling reveals circRNA1656 as a novel biomarker in high grade serous ovarian cancer.		circRNA7474	hsa_circ_STIL	STIL	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; RNA-seq	"circRNA7474 was validated as up-regulated in HGSOC tissues, consistent with circRNA sequencing. The study suggested it may become a potential tumor marker, but did not report a specific molecular mechanism."	0.429
31020693	Journal of cellular biochemistry	2019	"Circular RNA circ_001350 regulates glioma cell proliferation, apoptosis, and metastatic properties by acting as a miRNA sponge."		circ_001350	hsa_circ_BLNK	BLNK	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ_001350 is up-regulated in glioma tissues and cell lines and is associated with more severe clinicopathological features. Functionally, it promotes glioma cell proliferation, colony formation, migration and invasion while suppressing apoptosis. Mechanistically, circ_001350 acts as a sponge for miR-1236 to facilitate malignant progression of glioma."	0.6521
31020847	Epigenomics	2019	Identification of differentially expressed circular RNAs in chemoresistant colorectal cancer.		hsa_circ_32883	hsa_circ_EML5	EML5	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa circ 32883 was upregulated in chemoresistant HCT116 CRC cells and in FFPE CRC clinical samples from chemotherapy responders/nonresponders. The study proposed it as a promising biotarget and predicted a circRNA-miRNA-target gene regulatory relationship, especially involving hsa-miR-501-5p and genes enriched in cancer-related pathways."	0.5135
31020847	Epigenomics	2019	Identification of differentially expressed circular RNAs in chemoresistant colorectal cancer.		hsa_circ_0338	hsa_circ_FCHSD2	FCHSD2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa circ 0338 was identified as an upregulated circRNA in chemoresistant HCT116 CRC cells and was validated by qPCR in cell line samples and FFPE CRC clinical samples. The paper did not define a mechanistic axis for hsa circ 0338, but noted that it was selected partly because it was present in extracellular vesicles."	0.4773
31020847	Epigenomics	2019	Identification of differentially expressed circular RNAs in chemoresistant colorectal cancer.		hsa circRNA 103306	hsa_circ_SATB1	SATB1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	Microarray	"hsa circRNA 103306 was reported as the most upregulated circRNA in chemoresistant HCT116-R cells compared with parental HCT116-P cells, based on microarray profiling. The authors predicted five miRNAs that may bind this circRNA, suggesting a possible miRNA-sponge role, but no RT-qPCR or functional validation was reported for this circRNA."	0.329
31021476	Journal of cellular biochemistry	2019	Circular RNA expression profile in gingival tissues identifies circ_0062491 and circ_0095812 as potential treatment targets.	hsa_circ_0062491	circ_0062491			chronic periodontitis	MONDO:0005593	chronic periodontitis	down-regulated	RT-qPCR; RNA-seq	"circ_0062491 is significantly downregulated in periodontitis tissues and in P. gingivalis-treated THP1 cells. The study supports a circ_0062491/miR-584 interaction, with circ_0062491 acting as a miRNA sponge that suppresses miR-584 expression, suggesting relevance to periodontal inflammatory pathobiology and potential therapeutic targeting."	0.5922
31021476	Journal of cellular biochemistry	2019	Circular RNA expression profile in gingival tissues identifies circ_0062491 and circ_0095812 as potential treatment targets.	hsa_circ_0095812	circ_0095812			chronic periodontitis	MONDO:0005593	chronic periodontitis	up-regulated	RT-qPCR; RNA-seq	"circ_0095812 is significantly upregulated in periodontitis tissues compared with normal control tissues. It was identified as a key upregulated circRNA in the predicted circRNA-miRNA regulatory network and proposed as a potential treatment target, although no specific experimentally validated miRNA partner was reported for this circRNA."	0.4032
31023528	Biochemical and biophysical research communications	2019	Downregulated circular RNA hsa_circ_0067301 regulates epithelial-mesenchymal transition in endometriosis via the miR-141/Notch signaling pathway.	hsa_circ_0067301				ovarian endometriosis	MONDO:0006337	ovarian endometriosis	down-regulated	RT-qPCR	"hsa_circ_0067301 is significantly downregulated in ovarian endometriosis tissues. Functional assays indicate that loss of hsa_circ_0067301 promotes endometrial epithelial cell proliferation, migration/invasion and EMT, likely through a miR-141e5p-associated Notch-1/Hes-1 signaling mechanism. The study proposes hsa_circ_0067301 as a regulatory circRNA relevant to endometriosis pathogenesis and potential biomarker development."	0.5732
31026505	The international journal of biochemistry & cell biology	2019	Comprehensive circular RNA expression profiles and the tumor-suppressive function of circHIPK3 in ovarian cancer.	hsa_circ_0000284	circHIPK3 / hsa_circRNA001123	hsa_circ_HIPK3	HIPK3	ovarian cancer / OC	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR; RNA-seq	"circHIPK3 is down-regulated in epithelial ovarian cancer and functions as a tumor-suppressive regulator in this study. Its knockdown promotes proliferation, migration and invasion and reduces apoptosis, potentially through a predicted circHIPK3-miRNA-mRNA ceRNA network."	0.7618
31026505	The international journal of biochemistry & cell biology	2019	Comprehensive circular RNA expression profiles and the tumor-suppressive function of circHIPK3 in ovarian cancer.	hsa_circ_0007444	circRHOBTB3	hsa_circ_RHOBTB3	RHOBTB3	ovarian cancer / OC	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR; RNA-seq	"circRHOBTB3 was identified by RNA sequencing and validated by qRT-PCR as significantly down-regulated in epithelial ovarian cancer tissues compared with normal ovarian tissues. The study confirmed its circular structure, but did not experimentally investigate its biological function or molecular mechanism."	0.5909
31026505	The international journal of biochemistry & cell biology	2019	Comprehensive circular RNA expression profiles and the tumor-suppressive function of circHIPK3 in ovarian cancer.	hsa_circ_0001801	circPCMTD1	hsa_circ_PCMTD1	PCMTD1	ovarian cancer / OC	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR; RNA-seq	"circPCMTD1 was identified by RNA sequencing and validated by qRT-PCR as significantly down-regulated in epithelial ovarian cancer tissues compared with normal ovarian tissues. The study confirmed its circular structure, but did not experimentally investigate its biological function or molecular mechanism."	0.5909
31026505	The international journal of biochemistry & cell biology	2019	Comprehensive circular RNA expression profiles and the tumor-suppressive function of circHIPK3 in ovarian cancer.	hsa_circ_0000567	circSETD3	hsa_circ_SETD3	SETD3	ovarian cancer / OC	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR; RNA-seq	"circSETD3 was identified by RNA sequencing and validated by qRT-PCR as significantly down-regulated in epithelial ovarian cancer tissues compared with normal ovarian tissues. The study confirmed its circular structure, but did not experimentally investigate its biological function or molecular mechanism."	0.5909
31026505	The international journal of biochemistry & cell biology	2019	Comprehensive circular RNA expression profiles and the tumor-suppressive function of circHIPK3 in ovarian cancer.	hsa_circ_0020093	circATRNL1	hsa_circ_ATRNL1	ATRNL1	ovarian cancer / OC	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR; RNA-seq	"circATRNL1 was identified by RNA sequencing and validated by qRT-PCR as significantly down-regulated in epithelial ovarian cancer tissues compared with normal ovarian tissues. The study confirmed its circular structure, but did not experimentally investigate its biological function or molecular mechanism."	0.5909
31026505	The international journal of biochemistry & cell biology	2019	Comprehensive circular RNA expression profiles and the tumor-suppressive function of circHIPK3 in ovarian cancer.		circAC139769.1	hsa_circ_AC139769.1	LncAC139769.1	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; RNA-seq	"circAC139769.1 was identified as a newly found circRNA and validated by qRT-PCR as significantly up-regulated in epithelial ovarian cancer tissues compared with normal ovarian tissues. The study confirmed its circular structure, but did not experimentally investigate its biological function or molecular mechanism."	0.5909
31028816	Cellular signalling	2019	"Knockdown of cZNF292 suppressed hypoxic human hepatoma SMMC7721 cell proliferation, vasculogenic mimicry, and radioresistance."		circRNA ZNF292 / cZNF292	hsa_circ_ZNF292	ZNF292	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"In hypoxic human hepatoma SMMC7721 cells, cZNF292 is induced and acts as a pro-tumor circRNA that supports proliferation, vasculogenic mimicry and radioresistance. Mechanistically, cytoplasmic cZNF292 binds SOX9, limits SOX9 nuclear translocation, and activates Wnt/beta-catenin signaling; cZNF292 knockdown suppresses these effects and improves radiosensitivity in vitro and in xenograft models."	0.723
31029604	Gene	2019	Circ-ATP8A2 promotes cell proliferation and invasion as a ceRNA to target EGFR by sponging miR-433 in cervical cancer.	hsa_circ_0100129	circ-ATP8A2	hsa_circ_ATP8A2	ATP8A2	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ-ATP8A2 is up-regulated in cervical cancer tissues and cell lines and its high expression is associated with aggressive clinicopathologic features and poor overall survival. Functionally, circ-ATP8A2 promotes proliferation, migration and invasion while inhibiting apoptosis. Mechanistically, it acts as a ceRNA for miR-433 to increase EGFR expression and drive cervical cancer cell progression."	0.7396
31037450	Journal of gastroenterology	2019	Integrated analysis of circRNAs and mRNAs expression profile revealed the involvement of hsa_circ_0007919 in the pathogenesis of ulcerative colitis.	hsa_circ_0007919				ulcerative colitis / UC	MONDO:0005101	ulcerative colitis	down-regulated	RT-qPCR; Microarray	"hsa_circ_0007919 is down-regulated in inflamed UC mucosa and after inflammatory stimulation of intestinal epithelial cell lines. It is associated with Mayo endoscopic subscores and epithelial barrier-related molecules, and may protect epithelial integrity by sponging hsa-miR-138 and hsa-let-7a to regulate VIPR1 and EPC1."	0.6676
31037450	Journal of gastroenterology	2019	Integrated analysis of circRNAs and mRNAs expression profile revealed the involvement of hsa_circ_0007919 in the pathogenesis of ulcerative colitis.	hsa_circ_0004662				ulcerative colitis / UC	MONDO:0005101	ulcerative colitis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0004662 is up-regulated in inflamed UC mucosa and is induced by TNF-a, IL1-b, and LPS in intestinal epithelial cell models. Unlike hsa_circ_0007919, it did not show significant association with Mayo endoscopic subscores or epithelial barrier-related molecules in the reported analyses."	0.4773
31038801	Journal of cellular biochemistry	2019	"Overexpression of circ_0005198 sponges miR-1294 to regulate cell proliferation, apoptosis, migration, and invasion in glioma."	hsa_circ_0005198	circ_0005198			glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ_0005198 is up-regulated in glioma tissues and cell lines and is associated with larger tumor size, advanced WHO grade, and poor prognosis. Functionally, it promotes glioma cell proliferation, colony formation, migration and invasion while suppressing apoptosis. Mechanistically, circ_0005198 acts as an oncogenic circRNA by sponging miR-1294."	0.7396
31054187	Journal of cellular physiology	2019	Circ_0005075 promotes hepatocellular carcinoma progression by suppression of microRNA-335.	hsa_circ_0005075	circ_0005075			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0005075 is up-regulated in HCC tissues and serum, and high expression predicts poor prognosis. Functionally, it promotes HCC growth, proliferation, migration, invasion and cisplatin resistance while suppressing apoptosis, through a circ_0005075/miR-335/MAPK1 regulatory axis."	0.7754
31056795	Journal of cellular biochemistry	2019	Circular RNA circ_0103552 forecasts dismal prognosis and promotes breast cancer cell proliferation and invasion by sponging miR-1236.	hsa_circ_0103552	circ_0103552			breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0103552 is up-regulated in breast cancer tissues and cell lines and its high expression predicts unfavorable prognosis. Functionally, it promotes breast cancer cell proliferation, colony formation, migration and invasion while inhibiting apoptosis. Mechanistically, circ_0103552 exerts oncogenic activity at least partly by sponging miR-1236."	0.7396
31056800	Journal of cellular biochemistry	2019	Comprehensive circular RNA profiling reveals circ_0002060 as a potential diagnostic biomarkers for osteoporosis.	hsa_circ_0006873	circ_0006873			osteoporosis / OP	MONDO:0005298	osteoporosis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0006873/circ_0006873 was validated as significantly upregulated in serum or plasma samples from male osteoporosis patients. Its level correlated with BMD and T-score, indicating clinical association with osteoporosis severity, although it did not show diagnostic discrimination by ROC analysis."	0.5963
31056800	Journal of cellular biochemistry	2019	Comprehensive circular RNA profiling reveals circ_0002060 as a potential diagnostic biomarkers for osteoporosis.	hsa_circ_0002060	circ_0002060			osteoporosis / OP	MONDO:0005298	osteoporosis	up-regulated	RT-qPCR; Microarray	hsa_circ_0002060/circ_0002060 was validated as significantly upregulated in serum or plasma samples from male osteoporosis patients. Its expression correlated with BMD and T-score and showed potential diagnostic value for osteoporosis by ROC analysis.	0.5963
31069828	Journal of cellular biochemistry	2019	Dysregulated circRNA_100876 suppresses proliferation of osteosarcoma cancer cells by targeting microRNA-136.		circRNA_100876			osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circRNA_100876 is upregulated in osteosarcoma tissues and cell lines, and high expression is associated with larger tumor size, poor differentiation, and shorter overall survival. Functionally, circRNA_100876 promotes osteosarcoma cell proliferation and tumor growth, while its knockdown induces apoptosis and G2/M cell-cycle arrest. Mechanistically, circRNA_100876 directly binds miR-136, and inhibition of miR-136 reverses the growth suppression caused by circRNA_100876 silencing."	0.713
31069865	Journal of cellular biochemistry	2019	Elevation of circ-PITX1 upregulates interleukin 17 receptor D expression via sponging miR-518a-5p and facilitates cell progression in glioma.		circ-PITX1	hsa_circ_PITX1	PITX1	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ-PITX1 is upregulated in glioma tissues and cell lines, and its high expression is associated with larger tumor size and advanced WHO grade. Functionally, circ-PITX1 promotes glioma cell growth, migration, and invasion while inhibiting apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-518a-5p to relieve repression of IL17RD, forming a circ-PITX1/miR-518a-5p/IL17RD oncogenic axis."	0.6536
31074015	Journal of cellular biochemistry	2019	"Circular RNA rno_circ_0004002 regulates cell proliferation, apoptosis, and epithelial-mesenchymal transition through targeting miR-342-5p and Wnt3a in anorectal malformations."	rno_circ_0004002				anorectal malformations / ARM	MONDO:0001046	imperforate anus	down-regulated	RT-qPCR; RNA-seq	"rno_circ_0004002 is downregulated in ARM anorectal tissues of rat embryos, especially on GD19 and GD21. Functionally, it promotes IEC proliferation and EMT while suppressing apoptosis. Mechanistically, it sponges miR-342-5p to positively regulate Wnt3a, forming a rno_circ_0004002/miR-342-5p/Wnt3a regulatory pathway that may be therapeutically relevant for ARM."	0.7198
31074068	Journal of cellular biochemistry	2019	Identification of circular RNA-associated competing endogenous RNA network in the development of cleft palate.		circRNA_0954			cleft palate / CP	MONDO:0016064	cleft palate	up-regulated	RT-qPCR; RNA-seq	"In an ATRA-induced mouse cleft palate model, circRNA_0954 was up-regulated in embryonic palatal shelf tissues and validated by RT-qPCR. The study proposes that circRNA_0954 forms a ceRNA network with miRNA-881-3p and PRKAR1alpha, involving palatal fusion regulation and potentially contributing to dysfunctional palatal fusion in cleft palate."	0.4474
31081163	Journal of cellular biochemistry	2019	Elevation of circular RNA circ-POSTN facilitates cell growth and invasion by sponging miR-1205 in glioma.	hsa_circ_0030018	circ-POSTN	hsa_circ_POSTN	POSTN	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ-POSTN is up-regulated in glioma tissues and cell lines and high expression is associated with larger tumor size, advanced WHO grade, and shorter overall survival. Functionally, circ-POSTN promotes glioma cell proliferation, migration and invasion while suppressing apoptosis. Mechanistically, circ-POSTN acts as a miR-1205 sponge/ceRNA, and its oncogenic effects are partly dependent on regulation of miR-1205."	0.7078
31081718	"Cell cycle (Georgetown, Tex.)"	2019	Hsa_circ_0002577 promotes endometrial carcinoma progression via regulating miR-197/CTNND1 axis and activating Wnt/beta-catenin pathway.	hsa_circ_0002577	circ_0002577			endometrial carcinoma	MONDO:0002447	endometrial carcinoma	up-regulated	RT-qPCR	"hsa_circ_0002577 is up-regulated in endometrial carcinoma tissues and its high expression is associated with advanced FIGO stage, lymph node metastasis, and poor overall survival. Functionally, hsa_circ_0002577 promotes EC cell proliferation, migration, invasion, EMT and xenograft tumor growth. Mechanistically, it acts as a sponge for miR-197 to regulate CTNND1 and activate the Wnt/beta-catenin signaling pathway."	0.7795
31082770	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2019	Hsa_circ_0023404 enhances cervical cancer metastasis and chemoresistance through VEGFA and autophagy signaling by sponging miR-5047.	hsa_circ_0023404				cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"hsa_circ_0023404 is upregulated in cervical cancer tissues and functions as a pro-metastatic and pro-chemoresistance circRNA. It directly interacts with miR-5047, is linked to regulation of VEGFA, promotes invasion and lymphatic vessel formation, and enhances cisplatin resistance through autophagy-related signaling and reduced apoptosis."	0.6536
31087368	Journal of cellular physiology	2019	"circLRP6 regulates high glucose-induced proliferation, oxidative stress, ECM accumulation, and inflammation in mesangial cells."		circLRP6	mmu_circ_LRP6	LRP6	diabetic nephropathy / DN	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"In high glucose-treated mouse mesangial cells, circLRP6 is up-regulated and aggravates diabetic nephropathy-related cellular injury phenotypes. Mechanistically, circLRP6 sponges miR-205, increases HMGB1 expression, and activates the TLR4/NF-kappaB pathway, thereby promoting proliferation, oxidative stress, ECM accumulation, and inflammation."	0.5554
31103262	Biochemical and biophysical research communications	2019	Circ_ORC2 enhances the regulatory effect of miR-19a on its target gene PTEN to affect osteosarcoma cell growth.	hsa_circ_0006101	circ_ORC2	hsa_circ_ORC2		osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"hsa_circ_0006101/circ_ORC2 is up-regulated in human osteosarcoma cell lines and is mainly cytoplasmic. It binds miR-19a and enhances miR-19a-mediated repression of PTEN, leading to Akt pathway activation, increased proliferation and invasion, and reduced apoptosis in osteosarcoma cells."	0.6853
31103880	Atherosclerosis	2019	Identification of circular RNA Hsa_circ_0001879 and Hsa_circ_0004104 as novel biomarkers for coronary artery disease.	hsa_circ_0001879		hsa_circ_NIPSNAP3A	NIPSNAP3A	coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001879 is upregulated in PBMCs from CAD patients and was validated by qRT-PCR in a large case-control cohort. It showed diagnostic value for CAD and acted as an independent predictor of CAD occurrence, but no specific mechanistic axis was experimentally defined."	0.5047
31103880	Atherosclerosis	2019	Identification of circular RNA Hsa_circ_0001879 and Hsa_circ_0004104 as novel biomarkers for coronary artery disease.	hsa_circ_0004104		hsa_circ_SPARC	SPARC	coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR; Microarray	"hsa_circ_0004104 is upregulated in PBMCs from CAD patients and was validated as a potential diagnostic biomarker and independent predictor for CAD. Functionally, its overexpression in THP-1-derived macrophages promotes a proatherosclerotic expression program by increasing IDO1, MMP-8 and CD40 and decreasing ApoA I and RNASE1, suggesting contribution to atherosclerosis and CAD pathogenesis."	0.7242
31104012	Cancer biomarkers : section A of Disease markers	2019	Hsa_circ_001569 is an unfavorable prognostic factor and promotes cell proliferation and metastasis by modulating PI3K-AKT pathway in breast cancer.		hsa_circ_001569			breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"hsa_circ_001569 is up-regulated in breast cancer tissues and cell lines and high expression predicts poor overall survival. Functional knockdown experiments indicate that it promotes proliferation, migration, invasion, metastasis-related behavior and EMT while inhibiting apoptosis. Mechanistically, it contributes to breast cancer progression by activating the PI3K-AKT pathway."	0.6589
31106654	The International journal of biological markers	2019	Circular RNA ABCB10 promotes tumor progression and correlates with pejorative prognosis in clear cell renal cell carcinoma.			hsa_circ_ABCB10	ABCB10	clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR	"circ-ABCB10 is up-regulated in ccRCC cell lines and tumor tissues. Functionally, it promotes A498 cell proliferation and inhibits apoptosis, accompanied by changes in C-Caspase 3 and Bcl-2. Clinically, high tumor tissue circ-ABCB10 expression correlates with advanced pathological grade, higher TNM stage, and worse overall survival."	0.7169
31108165	Gene	2019	Downregulation of hsa_circ_0068087 ameliorates TLR4/NF-kappaB/NLRP3 inflammasome-mediated inflammation and endothelial cell dysfunction in high glucose conditioned by sponging miR-197.	hsa_circ_0068087				Diabetes mellitus / DM	MONDO:0005015	diabetes mellitus	up-regulated	RT-qPCR	"hsa_circ_0068087 is up-regulated in high glucose-treated HUVECs and is reported as increased in DM patients. Its knockdown suppresses high glucose-induced inflammatory cytokine secretion and endothelial dysfunction, likely through sponging miR-197 and regulating the TLR4/NF-kappaB/NLRP3 inflammasome pathway. The study suggests hsa_circ_0068087 as a potential therapeutic target for DM progression-related endothelial injury."	0.5554
31108351	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2019	Circular RNA circHIAT1 inhibits cell growth in hepatocellular carcinoma by regulating miR-3171/PTEN axis.		CircRNA Hippocampus Abundant Transcript 1	hsa_circ_HIAT1	HIAT1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"CircHIAT1 is down-regulated in HCC tissues and cell lines, and lower circHIAT1 expression is associated with poorer overall survival. Functionally, circHIAT1 suppresses HCC cell proliferation and tumor growth while promoting apoptosis. Mechanistically, cytoplasmic circHIAT1 acts as a sponge for miR-3171 to upregulate PTEN and modulate downstream AKT phosphorylation."	0.7896
31108493	Cytogenetic and genome research	2019	Microarray Profiling of Circular RNA Identifies hsa_circ_0126991 as a Potential Risk Factor for Essential Hypertension.	hsa_circ_0126991	circ_0126991			essential hypertension / EH	MONDO:0001134	essential hypertension	up-regulated	RT-qPCR; Microarray	"hsa_circ_0126991 was identified by human circRNA microarray and validated by qRT-PCR as up-regulated in whole blood from patients with essential hypertension. The study reports that hyperexpression of circ_0126991 is an important risk factor for EH and that circ_0126991 has diagnostic biomarker potential, with possible interaction with miR-10a-5p through a sponge-like mechanism."	0.6556
31109967	"Clinical science (London, England : 1979)"	2019	Hsa_circ_0009361 acts as the sponge of miR-582 to suppress colorectal cancer progression by regulating APC2 expression.	hsa_circ_0009361		hsa_circ_GNB1	GNB1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0009361 is downregulated in colorectal cancer tissues and cells and functions as a tumor suppressor. It sponges miR-582 to upregulate APC2, thereby inhibiting Wnt/beta-catenin signaling and suppressing CRC cell proliferation, EMT, migration, invasion, tumor growth and metastasis. The hsa_circ_0009361/miR-582/APC2 axis is proposed as a potential therapeutic target for CRC."	0.8511
31111536	Journal of cellular biochemistry	2019	Circular RNA expression profile of knee condyle in osteoarthritis by illumina HiSeq platform.	hsa_circ_0045714	circRNA-UNK	hsa_circ_UNK	UNK	Osteoarthritis / OA	MONDO:0005178	osteoarthritis	down-regulated	RNA-seq	"hsa_circ_0045714 was identified as a downregulated OA-related circRNA in severe knee condyle cartilage. The study predicted multiple miRNA targets and circRNA-miRNA-mRNA network involvement, suggesting a possible ceRNA-related role in OA progression."	0.3991
31111536	Journal of cellular biochemistry	2019	Circular RNA expression profile of knee condyle in osteoarthritis by illumina HiSeq platform.	hsa_circ_0005567		hsa_circ_HEATR5B	HEATR5B	Osteoarthritis / OA	MONDO:0005178	osteoarthritis	down-regulated	RNA-seq	"hsa_circ_0005567/circRNA-MSR was identified as a downregulated circRNA in severe OA knee condyle cartilage, although prior studies reported inconsistent regulation. The paper predicted hsa-miR-378a-3p and hsa-miR-20a-5p as targets and suggested possible involvement in an OA-related ceRNA pathway."	0.3991
31111536	Journal of cellular biochemistry	2019	Circular RNA expression profile of knee condyle in osteoarthritis by illumina HiSeq platform.	hsa_circ_0002485	circRNA-ATP9B	hsa_circ_ATP9B	ATP9B	Osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RNA-seq	"hsa_circ_0002485/circRNA-ATP9B was identified as an upregulated OA-related circRNA in severe knee condyle cartilage. The study predicted hsa-miR-340-5p as a target and a ceRNA network involving hsa-let-7a-5p and five mRNAs, suggesting a possible pathway in OA progression."	0.3991
31112718	Chemico-biological interactions	2019	Matrine induces apoptosis and autophagy of glioma cell line U251 by regulation of circRNA-104075/BCL-9.		circRNA-104075			glioma	MONDO:0021042	glioma	unknown	RT-qPCR	"In U251 human glioma cells, matrine decreases circRNA-104075 expression. circRNA-104075 overexpression antagonizes matrine-induced inhibition of proliferation and matrine-induced apoptosis and autophagy, while restoring Bcl-9 expression and PI3K/AKT and Wnt-beta-catenin signaling. The study suggests that suppression of circRNA-104075 contributes to the anti-tumor effect of matrine in glioma cells."	0.4236
31114952	Journal of molecular neuroscience : MN	2019	Circ-ZNF264 Promotes the Growth of Glioma Cells by Upregulating the Expression of miR-4493 Target Gene Apelin.	hsa_circ_0109952	circ-ZNF264	hsa_circ_ZNF264	ZNF264	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ-ZNF264 is upregulated in glioma cells and acts as an oncogenic circRNA. It binds and inhibits miR-4493, thereby increasing expression of the miR-4493 target gene apelin, which promotes glioma cell proliferation and invasion while suppressing apoptosis."	0.5607
31116090	"Cell cycle (Georgetown, Tex.)"	2019	Circular RNA 0001785 regulates the pathogenesis of osteosarcoma as a ceRNA by sponging miR-1200 to upregulate HOXB2.		circ-0001785			osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"circ-0001785 is up-regulated in osteosarcoma cell lines and acts as an oncogenic circRNA. It promotes proliferation and tumor growth while inhibiting apoptosis, at least partly through a ceRNA mechanism in which circ-0001785 sponges miR-1200 to up-regulate HOXB2 and modulates PI3K/Akt/mTOR and Bcl-2 family-related apoptotic signaling."	0.7795
31122696	Biochemical and biophysical research communications	2019	A circular RNA derived from COL6A3 functions as a ceRNA in gastric cancer development.	hsa_circ_0006401	circCOL6A3	hsa_circ_COL6A3	COL6A3	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circCOL6A3 (hsa_circ_0006401), derived from COL6A3, is up-regulated in gastric cancer cells and acts as an oncogenic circRNA. It is mainly cytoplasmic and functions as a ceRNA by binding miR-3064e5p, thereby derepressing COL6A3 mRNA and promoting proliferation and migration while reducing apoptosis of GC cells."	0.8118
31131447	Journal of cellular physiology	2019	Circular RNA circMAN2B2 facilitates glioma progression by regulating the miR-1205/S100A8 axis.			hsa_circ_MAN2B2	MAN2B2	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circMAN2B2 is up-regulated in glioma tissues and cell lines, and high expression is associated with poorer overall survival. Functionally, circMAN2B2 promotes glioma cell proliferation, migration, invasion and xenograft tumor growth. Mechanistically, it acts through the miR-1205/S100A8 axis, inhibiting miR-1205 and increasing S100A8 expression."	0.7588
31147216	Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver	2019	circZFR promotes cell proliferation and migration by regulating miR-511/AKT1 axis in hepatocellular carcinoma.	hsa_circ_0072088 	circZFR	hsa_circ_ZFR		hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circZFR is up-regulated in HCC tissues and cell lines and is associated with larger tumor size and advanced TNM stage. It promotes malignant phenotypes by sponging miR-511, thereby relieving repression of AKT1 and activating AKT1/beta-catenin signaling and proliferation-related proteins. Knockdown of circZFR suppresses proliferation, migration, invasion and xenograft growth while inducing apoptosis, supporting circZFR as a potential therapeutic target in HCC."	0.6917
31148183	"Hepatology (Baltimore, Md.)"	2020	A Noncoding Regulatory RNAs Network Driven by Circ-CDYL Acts Specifically in the Early Stages Hepatocellular Carcinoma.		Circ-CDYL	hsa_circ_CDYL	CDYL	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"Circ-CDYL is a human CDYL-derived circRNA specifically upregulated in early-stage HCC. It functions as a ceRNA sponge for miR-892a and miR-328-3p to regulate HDGF and HIF1AN, driving PI3K-AKT-mTORC1/beta-catenin and HIF1AN-NOTCH2-related signaling changes that promote EPCAM-positive tumor-initiating properties, proliferation, chemoresistance, and tumor growth. Clinically, Circ-CDYL alone or combined with HDGF and HIF1AN was proposed as a biomarker for early HCC discrimination/surveillance."	0.8892
31148222	Journal of cellular biochemistry	2019	Circular RNA circ_0079593 indicates a poor prognosis and facilitates cell growth and invasion by sponging miR-182 and miR-433 in glioma.	hsa_circ_0079593	circ_0079593	hsa_circ_IGF2BP3	IGF2BP3	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ_0079593 is up-regulated in glioma tissues and cell lines and high expression predicts worse survival, larger tumor size, and higher WHO grade. Functionally, it promotes glioma cell proliferation, migration and invasion while inhibiting apoptosis. Mechanistically, circ_0079593 acts as an oncogenic miRNA sponge that negatively regulates miR-182 and miR-433."	0.7396
31148290	Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology	2019	Hsa_circ_0005519 increases IL-13/IL-6 by regulating hsa-let-7a-5p in CD4+ T cells to affect asthma.	hsa_circ_0005519		hsa_circ_SNX13	SNX13	asthma	MONDO:0004979	asthma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0005519 is up-regulated in CD4+ T cells and PBMCs from asthmatic patients. It acts as a sponge for hsa-let-7a-5p and promotes IL-13 and IL-6 expression, contributing to airway eosinophilic inflammation. Its expression correlates with FeNO and eosinophil-related clinical features, suggesting biomarker potential for asthma."	0.7164
31153639	Biochemical and biophysical research communications	2019	Circular RNA circ_0020123 promotes non-small cell lung cancer progression by acting as a ceRNA for miR-488-3p to regulate ADAM9 expression.	hsa_circ_0020123	circ_0020123	hsa_circ_PDZD8	PDZD8	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0020123 is up-regulated in NSCLC tissues and cell lines and is associated with advanced clinicopathological features and poor overall survival. Functionally, it promotes NSCLC cell proliferation, migration and invasion while suppressing apoptosis. Mechanistically, circ_0020123 acts as a ceRNA for miR-488-3p/miR-488e3p to upregulate ADAM9, contributing to NSCLC progression."	0.7396
31153828	Molecular therapy : the journal of the American Society of Gene Therapy	2019	circRNA_0025202 Regulates Tamoxifen Sensitivity and Tumor Progression via Regulating the miR-182-5p/FOXO3a Axis in Breast Cancer.	hsa_circ_0025202	circRNA_0025202	hsa_circ_GAPDH	GAPDH	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0025202 is a GAPDH-derived cytoplasmic circRNA that is down-regulated in tamoxifen-resistant MCF7 cells and HR-positive breast cancer tissues. It suppresses tumor progression and enhances tamoxifen sensitivity by sponging miR-182-5p and regulating FOXO3a. Clinically, its low expression is associated with higher histological grade and lymph node metastasis, suggesting biomarker potential for tamoxifen response."	0.8685
31153886	Gene	2019	Circular RNA circ KMT2E is up-regulated in diabetic cataract lenses and is associated with miR-204-5p sponge function.	hsa_circ_0132876	circKMT2E	hsa_circ_KMT2E	KMT2E	diabetic cataract / DC	MONDO:0001687	diabetic cataract	up-regulated	RT-qPCR; RNA-seq	circKMT2E is significantly up-regulated in human diabetic cataract lens tissues and was validated by qRT-PCR. The study proposes that circKMT2E may act as a miR-204-5p sponge and participate in diabetic cataract pathogenesis through a predicted circKMT2E/miR-204-5p/autophagy-related mRNA network.	0.4032
31153886	Gene	2019	Circular RNA circ KMT2E is up-regulated in diabetic cataract lenses and is associated with miR-204-5p sponge function.	hsa_circ_0006057	circPAG1	hsa_circ_PAG1	PAG1	diabetic cataract / DC	MONDO:0001687	diabetic cataract	down-regulated	RT-qPCR; RNA-seq	"circPAG1 is significantly down-regulated in human diabetic cataract lens tissues and was validated by qRT-PCR. It was selected as a miR-204-5p-associated circRNA based on predicted binding, but the study did not experimentally verify its sponge function or downstream mechanism."	0.4032
31153886	Gene	2019	Circular RNA circ KMT2E is up-regulated in diabetic cataract lenses and is associated with miR-204-5p sponge function.	hsa_circ_0000284	circHIPK3	hsa_circ_HIPK3	HIPK3	diabetic cataract / DC	MONDO:0001687	diabetic cataract	down-regulated	RNA-seq	circHIPK3 was reported by this study's RNA-seq analysis as significantly down-regulated in diabetic cataract lens tissues. The paper did not validate this finding by qRT-PCR or define a diabetic-cataract-specific mechanism for circHIPK3.	0.2995
31155494	Cell metabolism	2019	CircACC1 Regulates Assembly and Activation of AMPK Complex under Metabolic Stress.		hsa_circ_001391	hsa_circ_ACC1	ACC1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Northern Blot; ISH	"circACC1 is a human ACC1-derived circular RNA that is up-regulated in most colorectal cancer tissues examined. It is induced by c-Jun under serum deprivation and directly binds AMPK b1 and g1 subunits to promote AMPK holoenzyme assembly, stability, and activation. Through AMPK-dependent metabolic reprogramming, circACC1 promotes glycolysis, fatty acid oxidation, cancer cell proliferation, and xenograft tumor growth."	0.8621
31157588	"Cell cycle (Georgetown, Tex.)"	2019	"Circular RNA 0047905 acts as a sponge for microRNA4516 and microRNA1227-5p, initiating gastric cancer progression."	hsa_circ_0047905	circular RNA 0047905	hsa_circ_SERPINB5	SERPINB5	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; ISH; Microarray	"circRNA0047905 is up-regulated in gastric cancer and functions as a tumor-promoting circRNA. It acts as a ceRNA for miR4516 and miR1227-5p to increase SERPINB5 and MMP11 expression, and its down-regulation suppresses Akt/CREB signaling activation. The study suggests circRNA0047905 may be a proliferative factor and potential biomarker or therapeutic target for gastric cancer."	0.659
31169020	Neoplasma	2019	Analysis of ceRNA network identifies prognostic circRNA biomarkers in bladder cancer.	hsa_circ_0076704	circ_0076704			bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0076704 was identified by GEO-based ceRNA analysis and validated by qRT-PCR as up-regulated in bladder cancer tissues and cells. It is significantly associated with overall survival and may act through a predicted circ_0076704/miR-214/target gene ceRNA network, making it a potential prognostic biomarker and drug target."	0.459
31169020	Neoplasma	2019	Analysis of ceRNA network identifies prognostic circRNA biomarkers in bladder cancer.	hsa_circ_0081963				bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0081963 was identified in a GEO-based bladder cancer ceRNA network and validated by qRT-PCR as up-regulated in bladder cancer tissues. The paper describes it as a potential OS-related circRNA, but does not report a specific validated miRNA target, downstream mechanism, or significant survival association for this circRNA."	0.348
31169020	Neoplasma	2019	Analysis of ceRNA network identifies prognostic circRNA biomarkers in bladder cancer.	hsa_circ_0001361				bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001361 was identified in a GEO-based bladder cancer ceRNA network and validated by qRT-PCR as up-regulated in bladder cancer tissues. The paper describes it as a potential OS-related circRNA, but does not report a specific validated miRNA target, downstream mechanism, or significant survival association for this circRNA."	0.348
31169343	Proteomics	2019	Identification of miR-145-5p-Centered Competing Endogenous RNA Network in Laryngeal Squamous Cell Carcinoma.	hsa_circ_0003519	circ_0003519	hsa_circ_ZEB1	ZEB1	laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	dysregulated	Microarray	"hsa_circ_0003519 was identified as a high-degree circRNA in the miR-145-5p-centered circRNA-miRNA-mRNA ceRNA network in LSCC cells. The paper predicts that it may function through CASP10-miR-145-5p-circ_0003519 and TPO-miR-145-5p-circ_0003519 axes related to apoptosis, stem cell features, and metabolic regulation, but this circRNA was not individually validated by RT-qPCR."	0.1768
31169343	Proteomics	2019	Identification of miR-145-5p-Centered Competing Endogenous RNA Network in Laryngeal Squamous Cell Carcinoma.	hsa_circ_0083752				laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	dysregulated	RT-qPCR; Microarray	"hsa_circ_0083752 was selected as a key ceRNA and experimentally validated by qPCR in miR-145-5p-overexpressing TU-177 and Hep2 LSCC cells. Its expression was significantly reduced after miR-145-5p overexpression, supporting its responsiveness within the miR-145-5p regulatory network, although the paper did not specify its downstream axis."	0.3684
31169343	Proteomics	2019	Identification of miR-145-5p-Centered Competing Endogenous RNA Network in Laryngeal Squamous Cell Carcinoma.	hsa_circ_0022951				laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	dysregulated	RT-qPCR; Microarray	"hsa_circ_0022951 was selected as a key ceRNA and experimentally validated by qPCR in miR-145-5p-overexpressing TU-177 and Hep2 LSCC cells. Its expression was significantly reduced after miR-145-5p overexpression, supporting its responsiveness within the miR-145-5p regulatory network, although the paper did not specify its downstream axis."	0.3684
31169343	Proteomics	2019	Identification of miR-145-5p-Centered Competing Endogenous RNA Network in Laryngeal Squamous Cell Carcinoma.	hsa_circ_0040331	circ_0040331			laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	dysregulated	Microarray	"circ_ 0040331 was reported as an example circRNA in the predicted circRNA-miRNA-mRNA ceRNA network generated from differentially expressed RNAs in miR-145-5p-overexpressing LSCC cells. Its proposed axis was CASP10-miR-550a-5p-circ_ 0040331, but no individual RT-qPCR validation or functional experiment was reported for this circRNA."	0.1768
31169343	Proteomics	2019	Identification of miR-145-5p-Centered Competing Endogenous RNA Network in Laryngeal Squamous Cell Carcinoma.	hsa_circ_0077485	circ_0077485			laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	dysregulated	Microarray	"circ_0077485 was reported as an example circRNA in the predicted circRNA-miRNA-mRNA ceRNA network generated from differentially expressed RNAs in miR-145-5p-overexpressing LSCC cells. Its proposed axis was GGT6-miR-550a-5p-circ_0077485, but no individual RT-qPCR validation or functional experiment was reported for this circRNA."	0.1768
31187432	"Interdisciplinary sciences, computational life sciences"	2019	Unearthing Regulatory Axes of Breast Cancer circRNAs Networks to Find Novel Targets and Fathom Pivotal Mechanisms.	hsa_circ_0065173	hsa_circRNA_103345	hsa_circ_SETD2	SETD2	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	Microarray	hsa_circ_0065173 was identified as a down-regulated hub circRNA in breast cancer microarray analysis. The study predicts that it acts as a super sponge for breast cancer-related miRNAs and participates in ceRNA/RBP regulatory networks with potential therapeutic relevance.	0.1768
31187432	"Interdisciplinary sciences, computational life sciences"	2019	Unearthing Regulatory Axes of Breast Cancer circRNAs Networks to Find Novel Targets and Fathom Pivotal Mechanisms.	hsa_circ_0020080	hsa_circRNA_100685	hsa_circ_FAM160B1	FAM160B1	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	Microarray	hsa_circ_0020080 was identified as a down-regulated hub circRNA in breast cancer microarray analysis. The study predicts that it acts as a super sponge for breast cancer-related miRNAs and participates in ceRNA/RBP regulatory networks with potential therapeutic relevance.	0.1768
31187432	"Interdisciplinary sciences, computational life sciences"	2019	Unearthing Regulatory Axes of Breast Cancer circRNAs Networks to Find Novel Targets and Fathom Pivotal Mechanisms.	hsa_circ_0001666	hsa_circRNA_104270	hsa_circ_FAM120B	FAM120B	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	Microarray	hsa_circ_0001666 was identified as a down-regulated hub circRNA in breast cancer microarray analysis. The study predicts that it acts as a super sponge for breast cancer-related miRNAs and participates in ceRNA/RBP regulatory networks with potential therapeutic relevance.	0.1768
31187432	"Interdisciplinary sciences, computational life sciences"	2019	Unearthing Regulatory Axes of Breast Cancer circRNAs Networks to Find Novel Targets and Fathom Pivotal Mechanisms.	hsa_circ_0001955	hsa_circRNA_101555	hsa_circ_CSNK1G1	CSNK1G1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	Microarray	hsa_circ_0001955 was identified as an up-regulated hub circRNA in breast cancer microarray analysis. The study predicts that it acts as a super sponge for breast cancer-related miRNAs and participates in ceRNA/RBP regulatory networks with potential therapeutic relevance.	0.1768
31187432	"Interdisciplinary sciences, computational life sciences"	2019	Unearthing Regulatory Axes of Breast Cancer circRNAs Networks to Find Novel Targets and Fathom Pivotal Mechanisms.	hsa_circ_0003227	hsa_circRNA_103812	hsa_circ_NUP155	NUP155	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	Microarray	hsa_circ_0003227 was identified as an up-regulated hub circRNA in breast cancer microarray analysis. The study predicts that it acts as a super sponge for breast cancer-related miRNAs and participates in ceRNA/RBP regulatory networks with potential therapeutic relevance.	0.1768
31187488	Journal of cellular physiology	2019	Circle RNA hsa_circRNA_100290 serves as a ceRNA for miR-378a to regulate oral squamous cell carcinoma cells growth via Glucose transporter-1 (GLUT1) and glycolysis.		hsa_circRNA_100290	hsa_circ_SLC30A7	SLC30A7	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"hsa_circRNA_100290/circRNA_100290 is up-regulated in OSCC tissues and cell lines. It promotes OSCC cell proliferation and glycolysis by acting as a ceRNA for miR-378a, thereby relieving miR-378a-mediated suppression of GLUT1; silencing circRNA_100290 suppresses glycolysis and colony formation and increases apoptosis."	0.6479
31198063	"Artificial cells, nanomedicine, and biotechnology"	2019	"Hsa_Circ_0001206 is downregulated and inhibits cell proliferation, migration and invasion in prostate cancer."	hsa_circ_0001206		hsa_circ_CRKL	CRKL	prostate cancer / PCa	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0001206 is downregulated in prostate cancer tissues and cell lines and has potential diagnostic value. Functional assays indicate that restoring hsa_circ_0001206 suppresses PCa proliferation, migration, invasion, and xenograft tumor growth, likely through the hsa_circ_0001206/miR-1285-5p/Smad4 axis, while DHX9 contributes to its downregulation."	0.7357
31198063	"Artificial cells, nanomedicine, and biotechnology"	2019	"Hsa_Circ_0001206 is downregulated and inhibits cell proliferation, migration and invasion in prostate cancer."	hsa_circ_0001633		hsa_circ_SOBP	SOBP	prostate cancer / PCa	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0001633 is downregulated in PCa tissues and was validated by qRT-PCR in 50 paired clinical samples. The study suggests it may serve as a diagnostic biomarker, and its potential mechanism was explored through a predicted ceRNA network, but no direct functional experiments were performed for this circRNA."	0.5047
31198063	"Artificial cells, nanomedicine, and biotechnology"	2019	"Hsa_Circ_0001206 is downregulated and inhibits cell proliferation, migration and invasion in prostate cancer."	hsa_circ_0009061		hsa_circ_KDM1A	KDM1A	prostate cancer / PCa	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0009061 is downregulated in PCa tissues and was validated by qRT-PCR in clinical samples. It showed diagnostic biomarker potential and was associated with clinicopathological features including Gleason score and pathological stage/tumor grade, while its mechanism was explored only by predicted ceRNA network analysis."	0.5047
31198064	Epigenomics	2019	Differential expression profiles and functional analysis of circular RNAs in children with fulminant myocarditis.	hsa_circ_0071542	circ 0071542			fulminant myocarditis / FM	MONDO:0002815	acute myocarditis	up-regulated	RT-qPCR; Microarray	"Hsa circ 0071542 was significantly upregulated in peripheral blood leukocytes from children with fulminant myocarditis and was validated by RT-qPCR. The study predicts that circ 0071542 may act through a ceRNA-like hsa-miR-8055/MAPK mechanism, potentially promoting inflammation and serving as a candidate biomarker associated with disease severity."	0.4032
31200957	Biochemical and biophysical research communications	2019	CircSAMD4A accelerates cell proliferation of osteosarcoma by sponging miR-1244 and regulating MDM2 mRNA expression.	hsa_circ_0004846	circ_101356 / circSAMD4	hsa_circ_SAMD4A	SAMD4A	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"circSAMD4A/hsa_circ_0004846 is up-regulated in osteosarcoma tissues and cell lines and is associated with metastasis and poorer recurrence-free survival. Functionally, it promotes osteosarcoma proliferation and stemness in vitro and accelerates xenograft tumor growth in vivo. Mechanistically, circSAMD4A mainly localizes in the cytoplasm and acts as a miR-1244 sponge to regulate MDM2 expression through a circSAMD4A/miR-1244/MDM2 axis."	0.8562
31204558	RNA biology	2019	CircRNA_28313/miR-195a/CSF1 axis modulates osteoclast differentiation to affect OVX-induced bone absorption in mice.		circRNA_28313			osteoporosis / OP	MONDO:0005298	osteoporosis	up-regulated	RT-qPCR; Microarray	"circRNA_28313 is up-regulated during RANKL + CSF1-induced osteoclast differentiation and in OVX mice. It promotes osteoclast differentiation and OVX-induced bone resorption by functioning as a ceRNA for miR-195a, thereby relieving miR-195a-mediated inhibition of CSF1. Knockdown of circRNA_28313 suppresses osteoclast formation and partially prevents OVX-induced bone loss in mice."	0.7615
31206208	Molecular carcinogenesis	2019	circ-PKD2 inhibits carcinogenesis via the miR-204-3p/APC2 axis in oral squamous cell carcinoma.	hsa_circ_0070401	circ-PKD2	hsa_circ_PKD2	PKD2	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	"circ-PKD2 (hsa_circ_0070401), derived from PKD2, is downregulated in OSCC and its low expression is associated with aggressive clinicopathological features. Functionally, circ-PKD2 suppresses OSCC proliferation, migration, invasion and xenograft tumor growth while promoting apoptosis and cell cycle arrest. Mechanistically, it sponges miR-204-3p to upregulate APC2 and suppress beta-catenin, AKT and ERK1/2-related oncogenic signaling."	0.7375
31207319	Cancer letters	2019	hsa_circ_0091570 acts as a ceRNA to suppress hepatocellular cancer progression by sponging hsa-miR-1307.	hsa_circ_0091570				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0091570 is down-regulated in HCC tissues and cell lines and functions as a tumor suppressor. It sponges miR-1307 as a ceRNA to regulate ISM1 expression, thereby inhibiting HCC proliferation, migration, invasion, metastasis and tumor growth while promoting apoptosis. Clinically, reduced hsa_circ_0091570 expression is associated with pathological progression, diagnostic potential and prognosis in HCC patients."	0.8824
31208717	Biochemical and biophysical research communications	2019	CircRAD23B facilitates proliferation and invasion of esophageal cancer cells by sponging miR-5095.		circular RNA-RAD23B / circRAD23B	hsa_circ_RAD23B	RAD23B	esophageal cancer 	MONDO:0007576	esophageal cancer	up-regulated	RT-qPCR	"circRAD23B is upregulated in esophageal cancer tissues and cancer cell lines. It promotes proliferation and invasion of esophageal cancer cells, acting through a ceRNA mechanism in which circRAD23B sponges miR-5095 to increase PARP2 and AKT2 expression."	0.7129
31209250	Cell research	2019	Intragenic antagonistic roles of protein and circRNA in tumorigenesis.		circPOK	hsa_circ_ZBTB7A	Zbtb7a	sarcoma	MONDO:0005089	sarcoma	up-regulated	RT-qPCR; RNA-seq	"This study identifies circPOK, a Zbtb7a-derived circRNA conserved in mouse and human cells, as an up-regulated proto-oncogenic circRNA in mesenchymal tumors including sarcoma and osteosarcoma. circPOK localizes in both nucleus and cytoplasm and promotes tumor growth, proliferation and angiogenesis by binding ILF2/ILF3 and enhancing ILF2/3-dependent transcriptional and post-transcriptional regulation of pro-proliferative and pro-angiogenic factors such as IL6 and VEGF. Unlike the linear Zbtb7a/Pokemon protein tumor-suppressive axis, circPOK has an independent and antagonistic oncogenic role and may be a therapeutic target in sarcoma."	0.8817
31209250	Cell research	2019	Intragenic antagonistic roles of protein and circRNA in tumorigenesis.		circPOK	mmu_circ_Zbtb7a	Zbtb7a	sarcoma	MONDO:0005089	sarcoma	up-regulated	RT-qPCR; RNA-seq	"This study identifies circPOK, a Zbtb7a-derived circRNA conserved in mouse and human cells, as an up-regulated proto-oncogenic circRNA in mesenchymal tumors including sarcoma and osteosarcoma. circPOK localizes in both nucleus and cytoplasm and promotes tumor growth, proliferation and angiogenesis by binding ILF2/ILF3 and enhancing ILF2/3-dependent transcriptional and post-transcriptional regulation of pro-proliferative and pro-angiogenic factors such as IL6 and VEGF. Unlike the linear Zbtb7a/Pokemon protein tumor-suppressive axis, circPOK has an independent and antagonistic oncogenic role and may be a therapeutic target in sarcoma."	0.8817
31213128	RNA biology	2019	Circular RNA profile of parathyroid neoplasms: analysis of co-expression networks of circular RNAs and mRNAs.	hsa_circ_0035563		hsa_circ_ANXA2	ANXA2	parathyroid carcinoma	MONDO:0012004	parathyroid gland carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"hsa_circ_0035563 is significantly upregulated in parathyroid carcinoma compared with parathyroid adenoma. Its expression correlates positively with ANXA2 mRNA and is associated with CDC73 mutations and recurrence, suggesting prognostic relevance in PC."	0.4297
31213128	RNA biology	2019	Circular RNA profile of parathyroid neoplasms: analysis of co-expression networks of circular RNAs and mRNAs.	hsa_circ_0017545		hsa_circ_AKR1C3	AKR1C3	parathyroid carcinoma	MONDO:0012004	parathyroid gland carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circ_0017545 is significantly upregulated in parathyroid carcinoma and correlates positively with AKR1C3 mRNA. The study suggests it may participate in circRNA-mRNA regulatory interactions during parathyroid tumourigenesis.	0.4032
31213128	RNA biology	2019	Circular RNA profile of parathyroid neoplasms: analysis of co-expression networks of circular RNAs and mRNAs.	hsa_circ_0001687				parathyroid carcinoma	MONDO:0012004	parathyroid gland carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001687 is significantly upregulated in parathyroid carcinoma compared with parathyroid adenoma. Its expression was also associated with recurrence status in PC patients, but the study did not define a specific molecular axis."	0.4032
31213128	RNA biology	2019	Circular RNA profile of parathyroid neoplasms: analysis of co-expression networks of circular RNAs and mRNAs.	hsa_circ_0075005		hsa_circ_NPM1	NPM1	parathyroid carcinoma	MONDO:0012004	parathyroid gland carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"hsa_circ_0075005 is significantly upregulated in parathyroid carcinoma and was validated by both RT-qPCR and FISH. It showed diagnostic potential for distinguishing PC from benign parathyroid lesions, with reported ROC AUC values of 0.770 by RT-qPCR analysis and 0.779 by FISH."	0.5267
31218163	Intractable & rare diseases research	2019	A potential significance of circ_0024169 down regulation in angiosarcoma tissue.	hsa_circ_0024169	circ_0024169	hsa_circ_CUL5	CUL5	angiosarcoma	MONDO:0024296	vascular neoplasm	down-regulated	RT-qPCR	"This study found reduced circ_0024169/CUL5 ratio in angiosarcoma and pyogenic granuloma compared with other tumors or normal skin, suggesting diagnostic value for vascular tumors. Relative circ_0024169 levels in angiosarcoma tissues were explored as a prognostic marker, with decreased levels tending to associate with poorer prognosis, although the survival difference was not statistically significant. No specific molecular mechanism or interacting miRNA was experimentally validated."	0.5261
31222831	Journal of gastroenterology and hepatology	2020	Identification of circular RNA-microRNA-messenger RNA regulatory network in hepatocellular carcinoma by integrated analysis.		hsa_circRNA_104268			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circRNA_104268 was up-regulated in HCC and validated by qRT-PCR. The study proposed that it may function as a ceRNA by capturing hsa-miR-214-3p and participating in a hsa_circRNA_104268/hsa-miR-214-3p/E2F2 regulatory axis.	0.4032
31222831	Journal of gastroenterology and hepatology	2020	Identification of circular RNA-microRNA-messenger RNA regulatory network in hepatocellular carcinoma by integrated analysis.		hsa_circRNA_104168			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circRNA_104168 was up-regulated in HCC and validated by qRT-PCR. The study proposed that it may function as a ceRNA by capturing hsa-miR-139-5p and participating in a hsa_circRNA_104168/hsa-miR-139-5p/HRAS regulatory axis.	0.4032
31222831	Journal of gastroenterology and hepatology	2020	Identification of circular RNA-microRNA-messenger RNA regulatory network in hepatocellular carcinoma by integrated analysis.		hsa_circRNA_104769			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	hsa_circRNA_104769 was down-regulated in HCC and validated by qRT-PCR. The study proposed that it may function as a ceRNA by capturing hsa-miR-93-5p and participating in a hsa_circRNA_104769/hsa-miR-93-5p/JUN regulatory axis.	0.4032
31226266	Experimental and molecular pathology	2019	Enhanced expression of circular RNA circ-DCAF6 predicts adverse prognosis and promotes cell progression via sponging miR-1231 and miR-1256 in gastric cancer.	hsa_circ_0009109	circ-DCAF6	hsa_circ_DCAF6	DCAF6	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ-DCAF6 is up-regulated in gastric cancer tissues and cell lines and its high expression predicts adverse prognosis. Functionally, circ-DCAF6 promotes gastric cancer cell proliferation, colony formation, migration and invasion while inhibiting apoptosis. Mechanistically, circ-DCAF6 acts as a miRNA sponge and upstream negative regulator of miR-1231 and miR-1256."	0.7365
31226633	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2019	circMTO1 promotes tumorigenesis and chemoresistance of cervical cancer via regulating miR-6893.	hsa_circ_0007874	circMTO1	hsa_circ_MTO1	MTO1	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"circMTO1 is up-regulated in cervical cancer cells and tumors. It promotes cervical cancer migration, invasion, tumor growth and cisplatin chemoresistance by sponging miR-6893 and regulating S100A1 and autophagy-related signaling. The study suggests circMTO1 may serve as a therapeutic target and biomarker for cervical cancer."	0.5634
31229921	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2019	"hsa_circ_0006168 sponges miR-100 and regulates mTOR to promote the proliferation, migration and invasion of esophageal squamous cell carcinoma."	hsa_circ_0006168	circ0006168	hsa_circ_CNOT6L	CNOT6L	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0006168 is up-regulated in ESCC tissues and cell lines and is associated with lymph node metastasis and advanced TNM stage. Functionally, it promotes ESCC cell proliferation, migration and invasion. Mechanistically, it acts as a ceRNA by sponging miR-100 and regulating mTOR expression, suggesting potential biomarker and therapeutic relevance."	0.8324
31232177	Autophagy	2020	Circular RNA circHIPK3 modulates autophagy via MIR124-3p-STAT3-PRKAA/AMPKalpha signaling in STK11 mutant lung cancer.		circHIPK3 / circular RNA HIPK3	hsa_circ_HIPK3	HIPK3	lung cancer	MONDO:0008903	lung cancer	unknown	RT-qPCR	"This study identifies circHIPK3 as an oncogenic circular RNA and autophagy regulator in NSCLC. circHIPK3 supports lung cancer cell proliferation, migration and invasion, while its knockdown induces autophagy through the MIR124-3p-STAT3-PRKAA/AMPKalpha pathway in STK11 mutant lung cancer cells. Clinically, the circHIPK3:linHIPK3 ratio, rather than circHIPK3 alone, was elevated in tumors and associated with poorer survival in advanced-stage NSCLC."	0.7325
31235259	Biochemical and biophysical research communications	2019	circRNA_0016624 could sponge miR-98 to regulate BMP2 expression in postmenopausal osteoporosis.	hsa_circ_0016624	circRNA_0016624 / circ_0016624			postmenopausal osteoporosis	MONDO:0008159	postmenopausal osteoporosis	down-regulated	RT-qPCR; RNA-seq	"circRNA_0016624 is down-regulated in postmenopausal osteoporosis. In this study, it functions as a miR-98 sponge, thereby increasing BMP2 expression and promoting osteogenic differentiation. Its overexpression showed a protective role against osteoporosis and was proposed as a potential therapeutic strategy."	0.6823
31241217	Journal of cellular biochemistry	2019	Circular RNA circPIP5K1A promotes non-small cell lung cancer proliferation and metastasis through miR-600/HIF-1alpha regulation.	hsa_circ_0014130	circPIP5K1A	hsa_circ_PIP5K1A	PIP5K1A	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circPIP5K1A (hsa_circ_0014130) is up-regulated in NSCLC cell lines and acts as an oncogenic circRNA. It promotes proliferation, migration, invasion, tumor growth, and pulmonary metastasis by sponging miR-600 and thereby increasing HIF-1alpha expression and EMT-related changes. Silencing circPIP5K1A suppresses NSCLC progression in vitro and in A549 xenograft models."	0.6004
31242973	Biochemical and biophysical research communications	2019	Dexamethasone-induced cytotoxicity in human osteoblasts is associated with circular RNA HIPK3 downregulation.	hsa_circ_0000284	Circular RNA HIPK3	hsa_circ_HIPK3	HIPK3	osteoporosis / OP	MONDO:0005298	osteoporosis	down-regulated	RT-qPCR	"This study shows that human circHIPK3 is downregulated by DEX in human osteoblasts and decreased in necrotic femoral head tissues from DEX-taking patients. Functionally, circHIPK3 overexpression protects osteoblasts from DEX-induced apoptosis and programmed necrosis, whereas circHIPK3 knockdown worsens cytotoxicity. Mechanistically, circHIPK3 downregulation promotes miR-124 accumulation and reduction of pro-survival targets SphK1 and STAT3, defining a circHIPK3-miR-124-related protective cascade."	0.5414
31255724	Cancer letters	2019	CircNR3C1 inhibits proliferation of bladder cancer cells by sponging miR-27a-3p and downregulating cyclin D1 expression.	hsa_circ_0001543	KU921432.1 / circ_0001543	hsa_circ_NR3C1	NR3C1	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"circNR3C1 is a human NR3C1-derived circRNA downregulated in bladder cancer tissues and cell lines. It acts as an anti-oncogenic cytoplasmic miRNA sponge for miR-27a-3p, reducing cyclin D1 protein expression, inducing G0/G1 arrest, and inhibiting bladder cancer cell proliferation and xenograft tumor growth. The study suggests circNR3C1 as a potential therapeutic target rather than a prognostic marker, since its lower expression was not correlated with grade or pathological stage."	0.866
31257089	"Pathology, research and practice"	2019	Circ-EIF4G3 promotes the development of gastric cancer by sponging miR-335.		circ-EIF4G3	hsa_circ_EIF4G3	EIF4G3	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ-EIF4G3 is up-regulated in gastric cancer tissues and GC cell lines, and its higher expression is associated with TNM stage and lymphatic metastasis. Functionally, circ-EIF4G3 promotes GC cell proliferation, invasion and migration. Mechanistically, it is mainly cytoplasmic and acts as a sponge for miR-335."	0.8256
31270819	Journal of cellular physiology	2020	Hsa_circ_0039411 promotes tumorigenesis and progression of papillary thyroid cancer by miR-1179/ABCA9 and miR-1205/MTA1 signaling pathways.	hsa_circ_0039411				papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"Hsa_circ_0039411 is up-regulated in papillary thyroid cancer tissues and cell lines. It acts as an oncogenic circRNA by promoting proliferation, migration and invasion while suppressing apoptosis. Mechanistically, it sponges miR-1179 and miR-1205 to upregulate ABCA9 and MTA1, suggesting potential therapeutic relevance in PTC."	0.6536
31271316	Biotechnic & histochemistry : official publication of the Biological Stain Commission	2019	Systematic identification of lncRNAs and circRNAs-associated ceRNA networks in human lumbar disc degeneration.	hsa_circ_0005139				Lumbar disc degeneration / LDD	MONDO:0044339	lumbar disk degenerative disorder	dysregulated	Microarray	"hsa_circ_0005139 was identified through public microarray-based bioinformatics analysis as a key dysregulated circRNA in LDD. It was predicted to participate in circRNA-miRNA-mRNA ceRNA regulation and to regulate more than 10 differentially expressed genes, suggesting potential value as a therapeutic target or biomarker."	0.1768
31271316	Biotechnic & histochemistry : official publication of the Biological Stain Commission	2019	Systematic identification of lncRNAs and circRNAs-associated ceRNA networks in human lumbar disc degeneration.	hsa_circ_0037858				Lumbar disc degeneration / LDD	MONDO:0044339	lumbar disk degenerative disorder	dysregulated	Microarray	"hsa_circ_0037858 was identified through public microarray-based bioinformatics analysis as a key dysregulated circRNA in LDD. It was predicted to participate in circRNA-miRNA-mRNA ceRNA regulation and to regulate more than 10 differentially expressed genes, suggesting potential value as a therapeutic target or biomarker."	0.1768
31271316	Biotechnic & histochemistry : official publication of the Biological Stain Commission	2019	Systematic identification of lncRNAs and circRNAs-associated ceRNA networks in human lumbar disc degeneration.	hsa_circ_0087890				Lumbar disc degeneration / LDD	MONDO:0044339	lumbar disk degenerative disorder	dysregulated	Microarray	"hsa_circ_0087890 was identified through public microarray-based bioinformatics analysis as a key dysregulated circRNA in LDD. It was predicted to participate in circRNA-miRNA-mRNA ceRNA regulation and to regulate more than 10 differentially expressed genes, suggesting potential value as a therapeutic target or biomarker."	0.1768
31271316	Biotechnic & histochemistry : official publication of the Biological Stain Commission	2019	Systematic identification of lncRNAs and circRNAs-associated ceRNA networks in human lumbar disc degeneration.	hsa_circ_0000189				Lumbar disc degeneration / LDD	MONDO:0044339	lumbar disk degenerative disorder	dysregulated	Microarray	"hsa_circ_0000189 was identified as a dysregulated circRNA in LDD-related network analysis. The study predicted that it participates in hsa-miR-486-5p-mediated ceRNA crosstalk with lncRNA DANCR and six mRNAs: PYCR2, TOB1, ARHGAP5, RBPJ, CD247, and SLC34A1."	0.1768
31276627	Biochemistry and cell biology = Biochimie et biologie cellulaire	2020	circ-NOTCH1 acts as a sponge of miR-637 and affects the expression of its target gene Apelin to regulate gastric cancer cell growth.	hsa_circ_0089548	circ-NOTCH1	hsa_circ_NOTCH1	NOTCH1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ-NOTCH1 is up-regulated in gastric cancer cells and tissues. It functions as a miR-637 sponge to relieve repression of Apelin, thereby promoting gastric cancer cell proliferation and invasion while reducing apoptosis."	0.6521
31276865	Chemosphere	2019	Identification of long non-coding RNA and circular RNA in mice after intra-tracheal instillation with fine particulate matter.		circRNA CBT15_circR_1011			PM 2.5-induced lung inflammation	MONDO:0005087	respiratory system disorder	down-regulated	RT-qPCR; RNA-seq	"circRNA CBT15_circR_1011 was significantly down-regulated in lung tissue from mice exposed to PM 2.5. The study suggests that this novel circRNA may be involved in PM 2.5-induced lung inflammation, with predicted gene interactions and enrichment in epigenetic/chromatin-related processes, but its exact function remains unclear."	0.3684
31276865	Chemosphere	2019	Identification of long non-coding RNA and circular RNA in mice after intra-tracheal instillation with fine particulate matter.		circRNA mm9_circ_005915			PM 2.5-induced lung inflammation	MONDO:0005087	respiratory system disorder	down-regulated	RT-qPCR; RNA-seq	"circRNA mm9_circ_005915 was significantly down-regulated in lung tissue from mice exposed to PM 2.5. The study suggests that this novel circRNA may be involved in PM 2.5-induced lung inflammation, with predicted gene interactions and enrichment in epigenetic/chromatin-related processes, but its exact function remains unclear."	0.3684
31278132	"Clinical science (London, England : 1979)"	2019	CircRNA-104718 acts as competing endogenous RNA and promotes hepatocellular carcinoma progression through microRNA-218-5p/TXNDC5 signaling pathway.		circRNA-104718 / circ104718			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH	"circRNA-104718 is up-regulated in HCC tissues and high expression is associated with poor survival, vascular invasion and metastasis. Functionally, it promotes HCC proliferation, migration, invasion, tumor growth and metastasis while inhibiting apoptosis. Mechanistically, it acts as a ceRNA for miR-218-5p, thereby relieving miR-218-5p-mediated repression of TXNDC5."	0.8148
31285870	Journal of thoracic disease	2019	Circular RNA profiling identified as a biomarker for predicting the efficacy of Gefitinib therapy for non-small cell lung cancer.	hsa_circ_0109320	hsa_circ_0109320_CBC1	hsa_circ_ZNF91	ZNF91	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0109320 was identified in plasma as a gefitinib efficacy-associated circRNA in NSCLC. Its elevated expression was validated by RT-qPCR and was associated with longer PFS, suggesting value as a non-invasive biomarker for EGFR-TKI response and prognosis."	0.6895
31285870	Journal of thoracic disease	2019	Circular RNA profiling identified as a biomarker for predicting the efficacy of Gefitinib therapy for non-small cell lung cancer.	hsa_circ_0134501	hsa_circ_0134501_CBC1	hsa_circ_ZNF117	ZNF117	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0134501 was identified and RT-qPCR-validated as a plasma circRNA differentially expressed between gefitinib-effective and -ineffective NSCLC patients. It showed moderate ROC performance for predicting treatment effect, but unlike hsa_circ_0109320, it was not associated with PFS in this study."	0.6895
31286543	Journal of cellular biochemistry	2019	Blood circRNAs as biomarkers for the diagnosis of community-acquired pneumonia.	hsa_circ_0018429				community-acquired pneumonia / CAP	MONDO:0043905	pneumonitis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0018429 is significantly up-regulated in peripheral blood from CAP patients and was validated by qPCR. It showed the strongest individual diagnostic performance among the four-circRNA panel, with AUC 0.8216 and specificity 80%, and was incorporated into a predicted circRNA-miRNA-mRNA network potentially linked to inflammatory and infection-related pathways."	0.5963
31286543	Journal of cellular biochemistry	2019	Blood circRNAs as biomarkers for the diagnosis of community-acquired pneumonia.	hsa_circ_0026579				community-acquired pneumonia / CAP	MONDO:0043905	pneumonitis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0026579 is significantly up-regulated in peripheral blood from CAP patients and was validated by qPCR. It has diagnostic value for CAP and additionally discriminates viral CAP from bacterial or mixed infection, with predicted interactions involving hsa-miR-199a, hsa-miR-484, and hsa-miR-638 within a putative circRNA-miRNA-mRNA network."	0.5963
31286543	Journal of cellular biochemistry	2019	Blood circRNAs as biomarkers for the diagnosis of community-acquired pneumonia.	hsa_circ_0125357				community-acquired pneumonia / CAP	MONDO:0043905	pneumonitis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0125357 is significantly up-regulated in peripheral blood from CAP patients and was validated by qPCR. It showed diagnostic value for CAP, with the best sensitivity among the four individual circRNAs, and was included in a predicted circRNA-miRNA-mRNA network associated with inflammatory and infection-related pathways."	0.5963
31286543	Journal of cellular biochemistry	2019	Blood circRNAs as biomarkers for the diagnosis of community-acquired pneumonia.	hsa_circ_0099188				community-acquired pneumonia / CAP	MONDO:0043905	pneumonitis	up-regulated	RT-qPCR; Microarray	hsa_circ_0099188 is significantly up-regulated in peripheral blood from CAP patients and was validated by qPCR. It showed modest but significant diagnostic value for CAP and was included in the four-circRNA diagnostic panel and predicted circRNA-miRNA-mRNA network.	0.5963
31293174	Epigenomics	2019	The potential targets for metastases: a study on altered circular RNA profile in breast cancer liver metastases.		hsa circ 21439			breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	"hsa circ 21439 was the most significantly upregulated circRNA in breast cancer liver metastasis tissues and 231LM cells. The study predicts that it may act as a miRNA sponge through miR-26b/EphA2 and miR-335/SOX4-related axes and may promote tumor metastasis, suggesting potential diagnostic or therapeutic relevance for BCLM."	0.6513
31293174	Epigenomics	2019	The potential targets for metastases: a study on altered circular RNA profile in breast cancer liver metastases.		hsa circ 11783			breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; RNA-seq	"hsa circ 11783 was the most significantly downregulated circRNA in breast cancer liver metastasis tissues and 231LM cells. The authors propose that it may act as a tumor-suppressive miRNA sponge, potentially involving a miR-365-5p/AKT-related pathway, and may suppress tumor metastasis."	0.6513
31295021	DNA and cell biology	2019	Identification of Circular RNA Related to Inflammation-Induced Lymphangiogenesis by Microarray Analysis.		cZNF609 / circZNF609	hsa_circ_ZNF609	ZNF609	corneal inflammatory lymphangiogenesis	MONDO:0021166	inflammatory disease	up-regulated	RT-qPCR; Microarray	"This study identified cZNF609 as an up-regulated circRNA in inflammation-induced lymphangiogenesis using microarray profiling and validated its elevation by qRT-PCR in inflamed HLECs, mouse corneal LG models, and human inflamed corneas. cZNF609 was mainly cytoplasmic and RNase R-resistant, and the authors proposed that it may act as a miR-184 sponge to regulate HPSE expression and lymphangiogenic processes, although the direct sponging mechanism requires further verification."	0.7091
31295021	DNA and cell biology	2019	Identification of Circular RNA Related to Inflammation-Induced Lymphangiogenesis by Microarray Analysis.		cZNF609 / circZNF609	mmu_circ_ZNF609	ZNF609	corneal inflammatory lymphangiogenesis	MONDO:0021166	inflammatory disease	up-regulated	RT-qPCR; Microarray	"This study identified cZNF609 as an up-regulated circRNA in inflammation-induced lymphangiogenesis using microarray profiling and validated its elevation by qRT-PCR in inflamed HLECs, mouse corneal LG models, and human inflamed corneas. cZNF609 was mainly cytoplasmic and RNase R-resistant, and the authors proposed that it may act as a miR-184 sponge to regulate HPSE expression and lymphangiogenic processes, although the direct sponging mechanism requires further verification."	0.7091
31297884	Journal of cellular biochemistry	2019	hsa_circRNA_100533 regulates GNAS by sponging hsa_miR_933 to prevent oral squamous cell carcinoma.		hsa_circRNA_100533			oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_100533 is downregulated in OSCC tissues and cell lines and appears to function as a tumor-suppressive circRNA. Mechanistically, it sponges hsa-miR-933 to regulate GNAS expression, thereby inhibiting proliferation and migration while promoting apoptosis of OSCC cells. The study proposes hsa_circRNA_100533 as a potential diagnostic biomarker and therapeutic target for OSCC."	0.8511
31297892	Journal of cellular biochemistry	2020	"SKP2, positively regulated by circ_ODC1/miR-422a axis, promotes the proliferation of retinoblastoma."		circ_ODC1	hsa_circ_ODC1	ODC1	retinoblastoma / RB	MONDO:0008380	retinoblastoma	up-regulated	RT-qPCR	"circ_ODC1 is up-regulated in retinoblastoma tissues and cell lines. It predominantly localizes in the cytoplasm, sponges miR-422a, and thereby increases SKP2 expression to promote RB cell proliferation. Silencing circ_ODC1 increases miR-422a and suppresses RB cell growth, while SKP2 overexpression partly rescues this effect."	0.6815
31300733	Oncogene	2019	Hsa_circ_101555 functions as a competing endogenous RNA of miR-597-5p to promote colorectal cancer progression.	hsa_circ_0001955	hsa_circ_101555	hsa_circ_CSNK1G1	CSNK1G1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circ101555 is up-regulated in CRC tissues and acts as an oncogenic circRNA. It promotes CRC progression by sponging miR-597-5p and increasing CDK6 and RPA3 expression, thereby enhancing proliferation, cell cycle progression, DNA repair and tumorigenesis while suppressing apoptosis. High circ101555 expression predicts poorer OS and DFS, supporting its potential as a prognostic biomarker and therapeutic target."	0.8942
31304776	Epigenomics	2019	circ_0001730 promotes proliferation and invasion via the miR-326/Wnt7B axis in glioma cells.	hsa_circ_0001730	circ_0001730	hsa_circ_EPHB4	EPHB4	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; Microarray	"circ 0001730 is upregulated in glioblastoma/glioma tissues and cell lines and its high expression is associated with advanced clinical stage and poorer survival. Functionally, circ 0001730 promotes glioblastoma cell proliferation, cell-cycle progression, invasion, EMT and in vivo tumor growth. Mechanistically, SP1 upregulates circ 0001730 via the host gene EPHB4, and cytoplasmic circ 0001730 sponges miR-326 to increase Wnt7B and activate Wnt/beta-catenin signaling."	0.8973
31306101	Cancer biomarkers : section A of Disease markers	2019	"Downregulated circular RNA itchy E3 ubiquitin protein ligase correlates with advanced pathologic T stage, high lymph node metastasis risk and poor survivals in prostate cancer patients."		circular RNA itchy E3 ubiquitin protein ligase / circ-ITCH	hsa_circ_ITCH	ITCH	prostate cancer / PCa	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR	"This retrospective clinical study found that circ-ITCH is significantly downregulated in prostate cancer tumor tissues compared with paired adjacent tissues. Low circ-ITCH expression was associated with advanced pathologic T stage, higher lymph node metastasis risk, and poorer survival, while high expression independently predicted better DFS and OS. The study supports circ-ITCH as a potential diagnostic and prognostic biomarker in prostate cancer, but did not experimentally investigate its molecular mechanism."	0.6578
31307197	Neoplasma	2020	Circular RNA circHIPK3 serves as a prognostic marker to promote chronic myeloid leukemia progression.		circHIPK3	hsa_circ_HIPK3	HIPK3	chronic myeloid leukemia / CML	MONDO:0011996	"chronic myelogenous leukemia, BCR-ABL1 positive"	up-regulated	RT-qPCR	"circHIPK3 is upregulated in PBMC and serum samples from CML patients and high serum circHIPK3 expression predicts poor overall survival. Functionally, circHIPK3 acts as an oncogenic circRNA in CML by promoting proliferation and suppressing apoptosis of CML cells. Mechanistically, the study suggests a circHIPK3/miR-124 axis involving downstream miR-124 targets such as B4GALT1 and p65."	0.7169
31307199	Neoplasma	2019	miRNA and mRNA expression profiles in gastric cancer patients and the relationship with circRNA.	hsa_circ_0001658	circ0001658			gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	Microarray	hsa_circ_0001658 was identified by GEO circRNA microarray analysis as significantly downregulated in gastric cancer versus controls. Bioinformatics analysis suggested that it is related to hsa-miR-375 and may participate in a circ0001658-miR-375-PAX6 regulatory axis with potential biomarker relevance in GC.	0.1768
31307199	Neoplasma	2019	miRNA and mRNA expression profiles in gastric cancer patients and the relationship with circRNA.	hsa_circ_0004928	circ0004928			gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	Microarray	hsa_circ_0004928 was identified by GEO circRNA microarray analysis as significantly downregulated in gastric cancer versus controls. Bioinformatics analysis suggested that it is related to hsa-miR-375 and may participate in a circ0004928-miR-375-PAX6 regulatory axis with potential biomarker relevance in GC.	0.1768
31307199	Neoplasma	2019	miRNA and mRNA expression profiles in gastric cancer patients and the relationship with circRNA.	hsa_circ_0000376	circ0000376			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	Microarray	hsa_circ_0000376 was identified by GEO circRNA microarray analysis as significantly upregulated in gastric cancer versus controls. Bioinformatics analysis suggested that it is related to hsa-miR-375 and may participate in a circ0000376-miR-375-PAX6 regulatory axis with potential biomarker relevance in GC.	0.1768
31311824	The Journal of neuroscience : the official journal of the Society for Neuroscience	2019	Circular RNA TLK1 Aggravates Neuronal Injury and Neurological Deficits after Ischemic Stroke via miR-335-3p/TIPARP.		circRNA TLK1 / mmu_circRNA_009932	hsa_circ_TLK1	TLK1	ischemic stroke	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; Microarray	"circTLK1 is up-regulated in ischemic stroke models and in plasma from patients with AIS. It aggravates neuronal injury and neurological deficits by sponging miR-335-3p and increasing TIPARP expression, while circTLK1 knockdown reduces infarct volume, apoptosis-related injury, brain atrophy, and functional deficits. Clinically, elevated plasma circTLK1 shows diagnostic potential and correlates with larger infarct volume."	0.8649
31311824	The Journal of neuroscience : the official journal of the Society for Neuroscience	2019	Circular RNA TLK1 Aggravates Neuronal Injury and Neurological Deficits after Ischemic Stroke via miR-335-3p/TIPARP.		circRNA TLK1 / mmu_circRNA_009932	mmu_circ_TLK1	TLK1	ischemic stroke	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; Microarray	"circTLK1 is up-regulated in ischemic stroke models and in plasma from patients with AIS. It aggravates neuronal injury and neurological deficits by sponging miR-335-3p and increasing TIPARP expression, while circTLK1 knockdown reduces infarct volume, apoptosis-related injury, brain atrophy, and functional deficits. Clinically, elevated plasma circTLK1 shows diagnostic potential and correlates with larger infarct volume."	0.8649
31315467	"Artificial cells, nanomedicine, and biotechnology"	2019	Large-scale quantitative genomics analyzes the circRNA expression profile and identifies the key circRNA in regulating cell proliferation during the proliferation phase of rat LR.		circ_03848			liver regeneration / LR	MONDO:0005154	liver disorder	up-regulated	RT-qPCR; RNA-seq	"circ_03848 was identified as a candidate key circRNA in rat liver regeneration and was up-regulated during the proliferation phase after partial hepatectomy. The study predicts that circ_03848 may function as a ceRNA by sponging several miRNAs and modulating downstream genes such as ODC1, RAD51, APEX1, and VEGFa to promote hepatocyte proliferation."	0.5761
31315467	"Artificial cells, nanomedicine, and biotechnology"	2019	Large-scale quantitative genomics analyzes the circRNA expression profile and identifies the key circRNA in regulating cell proliferation during the proliferation phase of rat LR.		circ_08236			liver regeneration / LR	MONDO:0005154	liver disorder	up-regulated	RT-qPCR; RNA-seq	"circ_08236 was identified as a candidate key circRNA and was up-regulated at 36 h after partial hepatectomy in rat regenerating liver. The study predicts that it may contribute to liver regeneration through a ceRNA mechanism involving rno-miR-143-5p and VEGFa, thereby regulating hepatocyte proliferation."	0.5761
31315467	"Artificial cells, nanomedicine, and biotechnology"	2019	Large-scale quantitative genomics analyzes the circRNA expression profile and identifies the key circRNA in regulating cell proliferation during the proliferation phase of rat LR.		circ_13398			liver regeneration / LR	MONDO:0005154	liver disorder	dysregulated	RT-qPCR; RNA-seq	circ_13398 was identified as a candidate key differentially expressed circRNA during the proliferation phase of rat liver regeneration. The study predicts that circ_13398 may bind rno-miR-484 and participate in a circRNA-miRNA-mRNA ceRNA network regulating hepatocyte proliferation.	0.5761
31315467	"Artificial cells, nanomedicine, and biotechnology"	2019	Large-scale quantitative genomics analyzes the circRNA expression profile and identifies the key circRNA in regulating cell proliferation during the proliferation phase of rat LR.		circ_15013			liver regeneration / LR	MONDO:0005154	liver disorder	dysregulated	RT-qPCR; RNA-seq	circ_15013 was identified as a candidate key differentially expressed circRNA during the proliferation phase of rat liver regeneration. The study predicts that circ_15013 may bind rno-miR-484 and participate in a circRNA-miRNA-mRNA ceRNA network regulating hepatocyte proliferation.	0.5761
31317555	Journal of cellular physiology	2020	Circular RNA hsa_circRNA_103809 promoted hepatocellular carcinoma development by regulating miR-377-3p/FGFR1/ERK axis.		hsa_circRNA_103809	hsa_circ_ZFR	ZFR	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"hsa_circRNA_103809 is up-regulated in HCC tissues and cell lines, and high expression predicts poorer survival. Functionally, it promotes HCC proliferation, cell cycle progression, migration, invasion, and xenograft tumor growth. Mechanistically, it binds and suppresses miR-377-3p, thereby increasing FGFR1 expression and affecting the FGFR1/ERK-related oncogenic program."	0.8457
31322270	Oncology reports	2019	Expression of circular RNA CDR1_AS in colon cancer cells increases cell surface PD_L1 protein levels.		cerebellar degeneration-related protein 1 transcript / ciRS7	hsa_circ_CDR1-AS		colon cancer	MONDO:0021063	malignant colon neoplasm	up-regulated	RT-qPCR; Northern Blot	"This study shows that CDR1-AS expression in colon cancer cells increases CMTM4 and CMTM6 transcript levels and elevates cell surface PD-L1 protein levels. The PD-L1 increase is not reversed by miR7 mimic overexpression, indicating a microRNA-7-independent mechanism. The authors propose that this onco-immunological effect may help explain the poor prognosis associated with high CDR1-AS expression in colon cancer."	0.753
31325635	Toxicology letters	2019	Circ_1639 induces cells inflammation responses by sponging miR-122 and regulating TNFRSF13C expression in alcoholic liver disease.		Circ_1639			alcoholic liver disease / ALD	MONDO:0043693	alcoholic liver diseases	up-regulated	RT-qPCR; ISH	"circ_1639 is upregulated in Kupffer cells from ethanol-fed mice and in LPS-treated RAW 264.7 cells. It functions as a pro-inflammatory circRNA by sponging miR-122, increasing TNFRSF13C expression, and promoting NF-kappaB pathway activation and inflammatory cytokine production. The study suggests that inhibiting circ_1639 may reduce inflammatory responses in alcoholic liver disease."	0.5979
31330234	Gene	2019	Overexpression of circ_0021093 circular RNA forecasts an unfavorable prognosis and facilitates cell progression by targeting the miR-766-3p/MTA3 pathway in hepatocellular carcinoma.	hsa_circ_0021093	circ_0021093	hsa_circ_ST		hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0021093 is upregulated in HCC tissues and cell lines and its high expression predicts poor overall survival. Functionally, it promotes HCC cell proliferation, migration and invasion while suppressing apoptosis. Mechanistically, circ_0021093 sponges miR-766-3p to increase MTA3 expression, forming a circ_0021093/miR-766-3p/MTA3 regulatory axis."	0.7408
31337246	Epigenomics	2019	CircPLK1 sponges miR-296-5p to facilitate triple-negative breast cancer progression.	hsa_circ_0038632	circRNA-0038632 / circPLK1	hsa_circ_PLK1	PLK1	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; Microarray	"CircPLK1 (hsa_circ_0038632), derived from the PLK1 locus, is upregulated in TNBC and its high expression predicts poor survival. Functionally, circPLK1 promotes TNBC proliferation, invasion, tumor growth and lung metastasis. Mechanistically, it mainly localizes to the cytoplasm and acts as a ceRNA sponge for miR-296-5p to enhance PLK1 expression."	0.7859
31344361	Experimental and molecular pathology	2019	Circular RNA circ_0008450 upregulates CXCL9 expression by targeting miR-577 to regulate cell proliferation and invasion in nasopharyngeal carcinoma.	hsa_circ_0008450	circ_0008450 / circ-CMTM3	hsa_circ_CMTM3	CMTM3	nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"circ_0008450 is up-regulated in NPC tissues and cell lines and acts as an oncogenic circRNA. It promotes NPC cell proliferation, migration and invasion while suppressing apoptosis by sponging miR-577 and increasing CXCL9 expression through the miR-577/CXCL9 axis."	0.6536
31349968	Biochemical and biophysical research communications	2019	Circ_SPECC1 enhances the inhibition of miR-526b on downstream KDM4A/YAP1 pathway to regulate the growth and invasion of gastric cancer cells.	hsa_circ_0000745	circ_SPECC1 / circ_-SPECC1	hsa_circ_SPECC1	SPECC1	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"circ_SPECC1 is down-regulated in gastric cancer cell lines and functions as a tumor suppressor by inhibiting proliferation and invasion while promoting apoptosis. Mechanistically, it binds miR-526b and enhances miR-526b-mediated inhibition of the KDM4A/YAP1 pathway, suggesting potential therapeutic relevance in gastric cancer."	0.6853
31351967	Life sciences	2019	Circular RNA hsa_circ_0007059 restrains proliferation and epithelial-mesenchymal transition in lung cancer cells via inhibiting microRNA-378.	hsa_circ_0007059				lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	"hsa_circ_0007059 is down-regulated in lung cancer tissues, and its lower expression is associated with higher tumor stage. Functional experiments in A549 and H1975 cells show that hsa_circ_0007059 overexpression inhibits proliferation and EMT while promoting apoptosis. Mechanistically, the study reports that hsa_circ_0007059 suppresses miR-378 and thereby inhibits Wnt/beta-catenin and ERK1/2 pathway activation."	0.5358
31364003	Human cell	2019	MiR-1261/circ-PTPRZ1/PAK1 pathway regulates glioma cell growth and invasion.	hsa_circ_0133159	circ-PTPRZ1	hsa_circ_PTPRZ1	PTPRZ1	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"In glioma cells, circ-PTPRZ1 is highly expressed and functions as a pro-tumor circRNA. miR-1261 suppresses circ-PTPRZ1 expression, while circ-PTPRZ1 promotes PAK1 phosphorylation/activation, leading to increased proliferation and invasion and reduced apoptosis. The study proposes the miR-1261/circ-PTPRZ1/PAK1 pathway as a potentially important signaling axis and therapeutic target in glioma."	0.5607
31368062	Journal of molecular neuroscience : MN	2020	Spinal circRNA-9119 Suppresses Nociception by Mediating the miR-26a-TLR3 Axis in a Bone Cancer Pain Mouse Model.		circ9119			bone cancer	MONDO:0002129	bone cancer	down-regulated	RT-qPCR; Microarray	"In a mouse model of bone cancer pain, spinal circ9119 is down-regulated and its overexpression alleviates thermal and mechanical hyperalgesia. Mechanistically, circ9119 acts as a miR-26a sponge, relieving miR-26a-mediated repression of TLR3 and forming a circ9119-miR-26a-TLR3 regulatory axis with potential analgesic relevance."	0.6683
31368365	Human gene therapy. Clinical development	2019	Circular RNA circVAPA Promotes Cell Proliferation in Hepatocellular Carcinoma.		circVAPA	hsa_circ_VAPA		hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circVAPA is up-regulated in human HCC cell lines and promotes HCC cell proliferation. Mechanistically, circVAPA mainly localizes in the cytoplasm, sponges miR-377-3p, and relieves miR-377-3p-mediated suppression of PSAP, suggesting potential diagnostic or therapeutic relevance in HCC."	0.5979
31377314	Gene	2019	Circ-IGF1R has pro-proliferative and anti-apoptotic effects in HCC by activating the PI3K/AKT pathway.	hsa_circ_0005035	circ-IGF1R	hsa_circ_IGF1R	IGF1R	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"This study identified circ-IGF1R (hsa_circ_0005035) as an IGF1R-derived circRNA upregulated in HCC tissues and HCC cell lines. High circ-IGF1R expression was associated with larger tumor size, and circ-IGF1R knockdown inhibited HCC cell proliferation while inducing apoptosis and G0/G1 cell cycle arrest. Mechanistically, circ-IGF1R appears to promote HCC progression at least partly by activating the PI3K/AKT pathway and modulating apoptosis-related proteins including Bcl-2, Bax and caspase-3."	0.6536
31381507	Cancer biomarkers : section A of Disease markers	2019	"Circular RNA ABCB10 correlates with advanced clinicopathological features and unfavorable survival, and promotes cell proliferation while reduces cell apoptosis in epithelial ovarian cancer."		circular RNA ABCB10 / circ-ABCB10	hsa_circ_ABCB10	ABCB10	epithelial ovarian cancer / EOC	MONDO:0005140	ovarian carcinoma	up-regulated	RT-qPCR	"In epithelial ovarian cancer, circ-ABCB10 is up-regulated in tumor tissues and several EOC cell lines. Higher circ-ABCB10 expression is associated with advanced clinicopathological features and worse overall survival, and functional assays indicate that it promotes proliferation and suppresses apoptosis while negatively regulating miR-1271, miR-1252 and miR-203."	0.7295
31385350	Journal of cellular biochemistry	2020	Differentially expressed circular RNAs in maternal and neonatal umbilical cord plasma from SGA compared with AGA.		hsa_circRNA15994-13	hsa_circ_NOTCH1	NOTCH1	Small for gestational age / SGA	MONDO:0005030	fetal growth restriction	dysregulated	RT-qPCR; Microarray	"hsa_circRNA15994-13 was differentially expressed in SGA, with increased levels in umbilical cord and maternal plasma and decreased levels in SGA placental tissue. The study predicts that it may act through a hsa_circRNA15994-13/hsa-miR-3619-5p/beta-catenin regulatory network affecting Wnt/beta-catenin signaling in SGA."	0.6193
31385350	Journal of cellular biochemistry	2020	Differentially expressed circular RNAs in maternal and neonatal umbilical cord plasma from SGA compared with AGA.	hsa_circ_0001359	circ_0001359	hsa_circ_PHC3	PHC3	Small for gestational age / SGA	MONDO:0005030	fetal growth restriction	down-regulated	RT-qPCR; Microarray	"hsa_circ_0001359 was down-regulated in SGA umbilical cord and maternal plasma and was validated by RT-PCR. The study predicted that it may participate in SGA-related ceRNA regulation through hsa-miR-4725-3p and hsa-miR-671-5p, although specific downstream functions were not experimentally defined."	0.6193
31385350	Journal of cellular biochemistry	2020	Differentially expressed circular RNAs in maternal and neonatal umbilical cord plasma from SGA compared with AGA.	hsa_circ_0001360	circ_0001360	hsa_circ_PHC3	PHC3	Small for gestational age / SGA	MONDO:0005030	fetal growth restriction	down-regulated	RT-qPCR; Microarray	"hsa_circ_0001360 was down-regulated in SGA umbilical cord and maternal plasma and was validated by RT-PCR. The study predicted that it may participate in SGA-related ceRNA regulation through hsa-miR-4725-3p and hsa-miR-671-5p, although specific downstream functions were not experimentally defined."	0.6193
31387394	"Artificial cells, nanomedicine, and biotechnology"	2019	"Silencing circular RNA circZNF609 restrains growth, migration and invasion by up-regulating microRNA-186-5p in prostate cancer."		circZNF609	hsa_circ_ZNF609	ZNF609	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circZNF609 is up-regulated in prostate cancer tissues. In PC3 and LNCaP cells, circZNF609 silencing inhibits proliferation/colony formation, migration and invasion while inducing apoptosis. Mechanistically, circZNF609 negatively regulates miR-186-5p and affects YAP1 and AMPK signaling pathways."	0.5434
31387405	"Artificial cells, nanomedicine, and biotechnology"	2019	The circular RNA circ-ITCH acts as a tumour suppressor in osteosarcoma via regulating miR-22.		circ-ITCH	hsa_circ_ITCH	ITCH	Osteosarcoma / OS	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR	"circ-ITCH is down-regulated in osteosarcoma tissues and cell lines. Functionally, circ-ITCH overexpression suppresses osteosarcoma cell viability, proliferation, migration and invasion while promoting apoptosis. Mechanistically, the study reports that circ-ITCH acts through down-regulation of miR-22 and inhibition of PTEN/PI3K/AKT and SP-1 pathways, suggesting a tumour-suppressive role and potential biomarker or therapeutic target value."	0.5434
31387917	Blood	2019	"circMYBL2, a circRNA from MYBL2, regulates FLT3 translation by recruiting PTBP1 to promote FLT3-ITD AML progression."	hsa_circ_0006332	circMYBL2	hsa_circ_MYBL2	MYBL2	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; Microarray	"circMYBL2 is a MYBL2-derived circRNA up-regulated in FLT3-ITD-positive AML compared with FLT3-ITD-negative AML. It promotes FLT3-ITD AML progression by recruiting PTBP1 to FLT3 mRNA, enhancing FLT3 kinase translation and downstream STAT5/c-MYC signaling. Knockdown of circMYBL2 inhibits proliferation, induces apoptosis and differentiation, reduces leukemia infiltration in vivo, extends mouse survival, and remains effective in quizartinib-resistant FLT3-ITD-positive cells."	0.8711
31401408	Leukemia research	2019	CircPAN3 contributes to drug resistance in acute myeloid leukemia through regulation of autophagy.	hsa_circ_0100181	circPAN3 / circRNA_100181	hsa_circ_PAN3	PAN3	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; RNA-seq	"circPAN3 is up-regulated in ADM-resistant AML cell lines and bone marrow samples from relapsed AML patients. It promotes AML drug resistance by enhancing autophagy and suppressing ADM-induced apoptosis, largely through activation of AMPK/mTOR signaling. The study also suggests a possible ceRNA mechanism involving circPAN3-miR-545-3p-TAK1, and proposes circPAN3 as a potential therapeutic target for drug-resistant AML."	0.7291
31402756	RNA biology	2019	Hypoxia-induced shedding of MICA and HIF1A-mediated immune escape of pancreatic cancer cells from NK cells: role of circ_0000977/miR-153 axis.	hsa_circ_0000977	circ_0000977			pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; Microarray	"In pancreatic cancer, hypoxia induces circ_0000977 expression. circ_0000977 functions as a miR-153 sponge to relieve miR-153-mediated repression of HIF1A and ADAM10, promoting MICA shedding and HIF1A-mediated immune escape from NK cell-mediated killing. Knockdown of circ_0000977 enhances NK cell killing of pancreatic cancer cells under hypoxia."	0.6815
31403357	The Journal of dermatological treatment	2021	Circular RNA ITCH downregulates GLUT1 and suppresses glucose uptake in melanoma to inhibit cancer cell proliferation.		Circular RNA ITCH	hsa_circ_ITCH	ITCH	melanoma	MONDO:0005105	melanoma	down-regulated	RT-qPCR	"Circular RNA ITCH is downregulated in melanoma tissues. In melanoma cells, ITCH overexpression downregulates GLUT1, suppresses glucose uptake, and inhibits cell proliferation, supporting a tumor-suppressive role."	0.5214
31406252	Oncogene	2019	circKDM4C suppresses tumor progression and attenuates doxorubicin resistance by regulating miR-548p/PBLD axis in breast cancer.	hsa_circ_0001839	circKDM4C	hsa_circ_KDM4C	KDM4C	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	"circKDM4C is a KDM4C-derived human circRNA that is downregulated in breast cancer tissues, metastatic breast cancer tissues, breast cancer cell lines, and doxorubicin-resistant cells. It functions as a tumor suppressor by sponging miR-548p and upregulating PBLD, thereby inhibiting proliferation, EMT, migration, invasion, metastasis, angiogenic tube formation, and doxorubicin resistance while promoting apoptosis. Clinically, low circKDM4C expression is associated with lymphatic metastasis and worse overall survival, suggesting prognostic and therapeutic relevance."	0.8868
31407396	Journal of cellular biochemistry	2020	Overexpression of circular RNA circ-CDC45 facilitates glioma cell progression by sponging miR-516b and miR-527 and predicts an adverse prognosis.	hsa_circ_0062270	circ-CDC45 / circ_0062270	hsa_circ_CDC45	CDC45	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ-CDC45 is up-regulated in human glioma tissues and cell lines, and high expression is associated with larger tumor size, higher WHO grade, and poor survival. Functionally, it acts as an oncogenic circRNA that promotes proliferation, colony formation, migration and invasion while inhibiting apoptosis, mainly by sponging and regulating miR-516b and miR-527."	0.7396
31407591	"Artificial cells, nanomedicine, and biotechnology"	2019	Circular RNA ZFR accelerates non-small cell lung cancer progression by acting as a miR-101-3p sponge to enhance CUL4B expression.		Circular RNA ZFR	hsa_circ_ZFR	ZFR	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circZFR is upregulated in NSCLC tissues and cell lines and functions as an oncogenic circRNA. Mechanistically, circZFR sponges miR-101-3p to enhance CUL4B expression, thereby promoting NSCLC cell proliferation, migration and invasion."	0.6777
31409903	Oncogene	2019	Circular RNA profile identifies circOSBPL10 as an oncogenic factor and prognostic marker in gastric cancer.	hsa_circ_0008549	circOSBPL10	hsa_circ_OSBPL10	OSBPL10	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"circOSBPL10 is a human OSBPL10-derived circRNA that is upregulated in gastric cancer tissues and associated with advanced T/TNM stage and poor OS/DFS. Functionally, it promotes GC proliferation, migration, invasion, tumor growth and lung metastasis by sponging miR-136-5p and increasing WNT2 expression, thereby activating Wnt/beta-catenin and EMT-related programs."	0.8837
31420809	Clinical rheumatology	2019	Altered expression of circular RNA in primary Sj_gren's syndrome.		hsa_circRNA_001264			primary Sj_gren's syndrome / pSS	MONDO:0019347	peeling skin syndrome	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_001264 is up-regulated in PBMCs from pSS patients and was validated by qRT-PCR after microarray screening. It is associated with pSS clinical/laboratory parameters and disease activity, shows diagnostic potential by ROC analysis, and may act through predicted interactions with miRNAs such as hsa-miR-18a-3p."	0.5963
31420809	Clinical rheumatology	2019	Altered expression of circular RNA in primary Sj_gren's syndrome.		hsa_circRNA_104121			primary Sj_gren's syndrome / pSS	MONDO:0019347	peeling skin syndrome	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_104121 is up-regulated in PBMCs from pSS patients and was validated by qRT-PCR after microarray screening. It is associated with pSS disease activity and several clinical/laboratory features, has diagnostic potential, and may participate in pSS pathogenesis through predicted miRNA interactions including miR-203a-3p and miR-143-3p."	0.5963
31420809	Clinical rheumatology	2019	Altered expression of circular RNA in primary Sj_gren's syndrome.		hsa_circRNA_045355			primary Sj_gren's syndrome / pSS	MONDO:0019347	peeling skin syndrome	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_045355 is down-regulated in PBMCs from pSS patients and was validated by qRT-PCR after microarray screening. Its expression is negatively related to SSDAI and associated with selected clinical/laboratory parameters, and ROC analysis suggests diagnostic potential for pSS."	0.5662
31421528	Placenta	2019	"CircHIPK3 is decreased in preeclampsia and affects migration, invasion, proliferation, and tube formation of human trophoblast cells."	hsa_circ_0000284	circHIPK3	hsa_circ_HIPK3	HIPK3	preeclampsia / PE	MONDO:0005081	preeclampsia	down-regulated	RT-qPCR	"This study found that circHIPK3 is down-regulated in placental tissues from patients with preeclampsia. Functional experiments in HTR-8/SVneo trophoblast cells indicate that circHIPK3 supports migration, invasion, proliferation, and tube formation, suggesting that reduced circHIPK3 may contribute to abnormal trophoblast behavior and preeclampsia pathogenesis. The molecular mechanism was not defined."	0.6261
31427049	International journal of oral and maxillofacial surgery	2020	Down-regulation of hsa_circ_0092125 is related to the occurrence and development of oral squamous cell carcinoma.	hsa_circ_0092125				oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0092125 is significantly down-regulated in OSCC tissues and OSCC cell lines. Lower hsa_circ_0092125 expression is associated with tumour size, TNM stage, lymph node metastasis, and shorter overall survival, suggesting prognostic biomarker potential. The study predicted possible miRNA binding sites but did not experimentally define a functional pathway."	0.5202
31432324	Pathology oncology research : POR	2020	Hsa_circ_0065149 is an Indicator for Early Gastric Cancer Screening and Prognosis Prediction.	hsa_circ_0065149		hsa_circ_SETD2	SETD2	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"This study identified hsa_circ_0065149 as a SETD2-derived circRNA that is down-regulated in gastric cancer tissues and early gastric cancer plasma exosomes. Its expression is clinically associated with tumor diameter, perineural invasion, diagnostic ROC performance, and overall survival, with high expression indicating poorer survival. Bioinformatics analyses suggest a potential circRNA-miRNA-mRNA regulatory role involving hsa-miR-197-5p, hsa-miR-222-3p, hsa-miR-330-5p and hsa-miR-486-3p during gastric carcinogenesis."	0.636
31432701	"Artificial cells, nanomedicine, and biotechnology"	2019	Silencing circular ANRIL protects HK-2 cells from lipopolysaccharide-induced inflammatory injury through up-regulating microRNA-9.		Circular antisense non-coding RNA in the INK4 locus / cANRIL	hsa_circ_ANRIL	ANRIL	chronic kidney disease / CKD	MONDO:0005300	chronic kidney disease	up-regulated	RT-qPCR	"cANRIL is up-regulated in LPS-treated HK-2 cells, an in vitro inflammatory injury model relevant to CKD. Silencing cANRIL alleviates LPS-induced injury by increasing cell viability and reducing apoptosis, IL-1b/IL-6 inflammatory cytokines, and ROS generation. Mechanistically, cANRIL knockdown up-regulates miR-9 and suppresses NF-jB and JNK/p38 pathway activation."	0.4236
31436645	Cornea	2019	Microarray Analysis of circRNA Expression Pattern in Corneal Neovascularization.		cZFP609	hsa_circ_ZFP609	ZFP609	corneal neovascularization	MONDO:0006713	corneal neovascularization	up-regulated	RT-qPCR; Microarray	"cZFP609 was the most upregulated circRNA in the mouse corneal neovascularization model, and its human ortholog was significantly increased in vascularized human corneas. The authors suggest that cZFP609 may contribute to corneal neovascularization and could be a therapeutic target, although its specific molecular mechanism was not experimentally defined."	0.5922
31436645	Cornea	2019	Microarray Analysis of circRNA Expression Pattern in Corneal Neovascularization.		cZFP609	mmu_circ_ZFP609	ZFP609	corneal neovascularization	MONDO:0006713	corneal neovascularization	up-regulated	RT-qPCR; Microarray	"cZFP609 was the most upregulated circRNA in the mouse corneal neovascularization model, and its human ortholog was significantly increased in vascularized human corneas. The authors suggest that cZFP609 may contribute to corneal neovascularization and could be a therapeutic target, although its specific molecular mechanism was not experimentally defined."	0.5922
31436645	Cornea	2019	Microarray Analysis of circRNA Expression Pattern in Corneal Neovascularization.		cKifap3	hsa_circ_Kifap3	Kifap3	corneal neovascularization	MONDO:0006713	corneal neovascularization	down-regulated	RT-qPCR; Microarray	"cKifap3 was the most downregulated circRNA in the mouse corneal neovascularization model, and its human ortholog was significantly decreased in vascularized human corneas. Functional experiments in HUVECs showed that cKifap3 knockdown promotes endothelial proliferation, migration, and tube formation, indicating that endogenous cKifap3 may suppress endothelial angiogenic function and participate in corneal neovascularization pathogenesis."	0.6815
31436645	Cornea	2019	Microarray Analysis of circRNA Expression Pattern in Corneal Neovascularization.		cKifap3	mmu_circ_Kifap3	Kifap3	corneal neovascularization	MONDO:0006713	corneal neovascularization	down-regulated	RT-qPCR; Microarray	"cKifap3 was the most downregulated circRNA in the mouse corneal neovascularization model, and its human ortholog was significantly decreased in vascularized human corneas. Functional experiments in HUVECs showed that cKifap3 knockdown promotes endothelial proliferation, migration, and tube formation, indicating that endogenous cKifap3 may suppress endothelial angiogenic function and participate in corneal neovascularization pathogenesis."	0.6815
31445025	Life sciences	2019	Downregulation of hsa_circ_0007534 restricts the proliferation and invasion of cervical cancer through regulating miR-498/BMI-1 signaling.	hsa_circ_0007534				cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"hsa_circ_0007534 is upregulated in cervical cancer tissues and cell lines and functions as an oncogenic circRNA. Its knockdown suppresses cervical cancer cell proliferation, colony formation, and invasion by increasing miR-498 and reducing BMI-1 expression through the hsa_circ_0007534/miR-498/BMI-1 axis, suggesting therapeutic relevance."	0.7032
31452245	Journal of cellular biochemistry	2019	circPIP5K1A serves as a competitive endogenous RNA contributing to ovarian cancer progression via regulation of miR-661/IGFBP5 signaling.	hsa_circ_0014130	circPIP5K1A	hsa_circ_PIP5K1A	PIP5K1A	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circPIP5K1A is up-regulated in ovarian cancer tissues and cell lines, and high expression is associated with poor prognosis. Functionally, circPIP5K1A promotes ovarian cancer proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, it acts as a ceRNA for miR-661 to regulate IGFBP5 expression through the circPIP5K1A/miR-661/IGFBP5 axis."	0.7373
31456215	International journal of cancer	2020	"Plasma circular RNA panel to diagnose hepatitis B virus-related hepatocellular carcinoma: A large-scale, multicenter study."	hsa_circ_0000976				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000976 is up-regulated in plasma from HBV-related HCC patients and in HCC tissues compared with adjacent noncancerous liver tissues. It is secreted by HCC cells into plasma and was incorporated into a three-circRNA diagnostic panel that outperformed AFP for detecting HCC, Small-HCC, AFP-negative HCC and AFP-negative Small-HCC."	0.7352
31456215	International journal of cancer	2020	"Plasma circular RNA panel to diagnose hepatitis B virus-related hepatocellular carcinoma: A large-scale, multicenter study."	hsa_circ_0007750				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0007750 is up-regulated in plasma from HBV-related HCC patients and in HCC tissues compared with adjacent noncancerous liver tissues. It is secreted by HCC cells into plasma and was incorporated into a three-circRNA diagnostic panel that outperformed AFP for detecting HCC, Small-HCC, AFP-negative HCC and AFP-negative Small-HCC."	0.7352
31456215	International journal of cancer	2020	"Plasma circular RNA panel to diagnose hepatitis B virus-related hepatocellular carcinoma: A large-scale, multicenter study."	hsa_circ_0139897				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0139897 is up-regulated in plasma from HBV-related HCC patients, positively correlated with expression in HCC tissues, and decreases after hepatectomy, although HCC versus ANL tissue expression was not significantly different. It is secreted by HCC cells into plasma and was incorporated into a three-circRNA diagnostic panel that outperformed AFP for detecting HCC and related clinical subgroups."	0.7352
31456425	"Artificial cells, nanomedicine, and biotechnology"	2019	The circular RNA hsa-circ-0072309 plays anti-tumour roles by sponging miR-100 through the deactivation of PI3K/AKT and mTOR pathways in the renal carcinoma cell lines.	hsa_circ_0072309				renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	down-regulated	RT-qPCR	"Hsa-circ-0072309 is down-regulated in renal tumour tissue and functions as a tumour-suppressive circRNA in CAKI-1 and ACHN renal carcinoma cell lines. Its overexpression inhibits proliferation, migration, invasion and PI3K/AKT/mTOR signaling while promoting apoptosis, at least partly by negatively regulating miR-100."	0.5414
31476285	The American journal of pathology	2019	Down-Regulation of Circular RNA_000926 Attenuates Renal Cell Carcinoma Progression through miRNA-411-Dependent CDH2 Inhibition.		circ_000926 / hsa_circ_000926			renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR; Microarray	"circ_000926 is up-regulated in RCC tissues and cell lines. It promotes RCC proliferation, migration, invasion, EMT, metastasis-related phenotypes, and xenograft tumor growth by sponging miR-411 and increasing CDH2 expression. Silencing circ_000926 suppresses RCC progression, suggesting circ_000926 as a potential therapeutic target."	0.7859
31476947	The International journal of biological markers	2019	Hsa_circ_0005075 promotes the proliferation and invasion of colorectal cancer cells.	hsa_circ_0005075		hsa_circ_SHPRH	SHPRH	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"hsa_circ_0005075 is up-regulated in colorectal cancer tissues, plasma, and CRC cell lines. Its high expression correlates with advanced clinicopathological features and poor overall survival, and functional assays show that it promotes CRC cell proliferation and invasion. The study supports hsa_circ_0005075 as a potential diagnostic marker and therapeutic target for colorectal cancer, although a specific downstream molecular axis was not defined."	0.6419
31479678	Life sciences	2020	Circular RNA 4099 aggravates hydrogen peroxide-induced injury by down-regulating microRNA-706 in L02 cells.		Circular RNA 4099 / hsa_circRNA_100759			hepatitis	MONDO:0002251	hepatitis	up-regulated	RT-qPCR	"In an in vitro H2O2-induced L02 cell injury model used to mimic hepatitis-related liver damage, circRNA-4099 was up-regulated and worsened cell injury. Mechanistically, circRNA-4099 negatively regulated miR-706, thereby promoting apoptosis, ROS production, fibrosis-associated protein expression, and activation of keap1/Nrf2 and p38 MAPK signaling cascades."	0.5607
31479715	Gene	2019	Circular RNA circ-PRMT5 facilitates non-small cell lung cancer proliferation through upregulating EZH2 via sponging miR-377/382/498.	hsa_circ_0031250	circ-PRMT5	hsa_circ_PRMT5	PRMT5	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circ-PRMT5 is up-regulated in NSCLC tissues and cell lines and is associated with aggressive clinicopathological features and poor survival. It promotes NSCLC proliferation and xenograft tumor growth by sponging miR-377, miR-382 and miR-498, thereby upregulating EZH2. The study supports circ-PRMT5 as an oncogenic circRNA and potential prognostic biomarker in NSCLC."	0.8823
31482388	Molecular and cellular biochemistry	2019	Silencing circular RNA circ_0010729 protects human cardiomyocytes from oxygen-glucose deprivation-induced injury by up-regulating microRNA-145-5p.	hsa_circ_0010729	CircRNA_0010729 / circ_0010729			myocardial ischemia	MONDO:0024644	myocardial ischemia	up-regulated	RT-qPCR	"circ_0010729 is up-regulated in OGD-treated human cardiomyocytes and contributes to OGD-induced myocardial ischemia-like injury. Its overexpression worsens injury by reducing cell viability and migration and increasing apoptosis, while knockdown is protective. Mechanistically, circ_0010729 negatively regulates miR-145-5p, and silencing circ_0010729 activates mTOR and MEK/ERK pathways through miR-145-5p up-regulation."	0.421
31487644	Pregnancy hypertension	2019	Circular RNA expression profiling identifies hsa_circ_0011460 as a novel molecule in severe preeclampsia.	hsa_circ_0011460		hsa_circ_SLCO2A1		severe preeclampsia / SPE	MONDO:0001641	severe pre-eclampsia	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0011460 is up-regulated in SPE placentae and was validated by qRT-PCR. The study focused on this circRNA and showed by RIP that it directly interacts with the host gene-encoded PGT protein, suggesting a possible role in SPE pathogenesis and therapeutic or diagnostic potential."	0.7647
31487644	Pregnancy hypertension	2019	Circular RNA expression profiling identifies hsa_circ_0011460 as a novel molecule in severe preeclampsia.	hsa_circ_0007611				severe preeclampsia / SPE	MONDO:0001641	severe pre-eclampsia	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0007611 is an up-regulated circRNA in SPE placentae validated by qRT-PCR. It was included in the predicted ceRNA network, which implicated angiogenesis, hypoxia response, inflammatory response and VEGFR signaling in PE."	0.585
31487644	Pregnancy hypertension	2019	Circular RNA expression profiling identifies hsa_circ_0011460 as a novel molecule in severe preeclampsia.	hsa_circ_0002888				severe preeclampsia / SPE	MONDO:0001641	severe pre-eclampsia	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0002888 is an up-regulated circRNA in SPE placentae validated by qRT-PCR. It was included in the predicted ceRNA network, with downstream processes related to angiogenesis, hypoxia response, inflammatory response and VEGFR signaling."	0.585
31487644	Pregnancy hypertension	2019	Circular RNA expression profiling identifies hsa_circ_0011460 as a novel molecule in severe preeclampsia.	hsa_circ_0007445				severe preeclampsia / SPE	MONDO:0001641	severe pre-eclampsia	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0007445 is an up-regulated circRNA in SPE placentae validated by qRT-PCR. The study included it in a predicted ceRNA network associated with PE-related angiogenesis, hypoxia response, inflammatory response and VEGFR signaling."	0.585
31487644	Pregnancy hypertension	2019	Circular RNA expression profiling identifies hsa_circ_0011460 as a novel molecule in severe preeclampsia.	hsa_circ_0012737				severe preeclampsia / SPE	MONDO:0001641	severe pre-eclampsia	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0012737 is a down-regulated circRNA in SPE placentae validated by qRT-PCR. It was part of the predicted SPE ceRNA network, which was linked to angiogenesis, hypoxia response, inflammation and VEGFR signaling."	0.585
31487644	Pregnancy hypertension	2019	Circular RNA expression profiling identifies hsa_circ_0011460 as a novel molecule in severe preeclampsia.	hsa_circ_0017068				severe preeclampsia / SPE	MONDO:0001641	severe pre-eclampsia	dysregulated	RNA-seq	"hsa_circ_0017068 was identified as a dysregulated circRNA in SPE placentae and included in a predicted ceRNA network. Because the text reports an opposite expression trend between RNA-Seq and qRT-PCR for this circRNA, the association is considered low-confidence."	0.1768
31490018	Journal of cellular biochemistry	2020	Circular RNA ciRS-7 inhibits autophagy of ESCC cells by functioning as miR-1299 sponge to target EGFR signaling.		ciRS-7 / CDR1as	hsa_circ_CDR1	CDR1	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"This study identifies ciRS-7/CDR1as as a functional circRNA in ESCC cells that suppresses starvation- or rapamycin-induced autophagy. Mechanistically, ciRS-7 sponges miR-1299, rescues EGFR expression and downstream Akt/mTOR phosphorylation, and thereby counteracts miR-1299-induced autophagy."	0.5802
31492499	Biochemical and biophysical research communications	2019	Hsa_circ_0035483 sponges hsa-miR-335 to promote the gemcitabine-resistance of human renal cancer cells by autophagy regulation.	hsa_circ_0035483	circ_0035483			renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0035483 is up-regulated in RCC/renal cancer tissues and renal cancer cell lines. It promotes gemcitabine resistance by sponging hsa-miR-335 and increasing CCNB1 expression, which activates autophagy, promotes cell viability/tumor growth, and inhibits apoptosis. Knockdown of hsa_circ_0035483 enhances gemcitabine sensitivity in vivo."	0.7745
31493405	European journal of pharmacology	2019	Circular RNA circ-PITX1 promotes the progression of glioblastoma by acting as a competing endogenous RNA to regulate miR-379-5p/MAP3K2 axis.	hsa_circ_0074027	circ-PITX1 / circular RNA PITX1	hsa_circ_PITX1	PITX1	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; Microarray	circ-PITX1 is upregulated in glioblastoma tissues and cell lines. It promotes GBM cell proliferation and inhibits apoptosis by acting as a cytoplasmic ceRNA that sponges miR-379-5p and increases MAP3K2 expression.	0.8195
31493407	European journal of pharmacology	2019	Circular RNA expression profile of liver tissues in an EtOH-induced mouse model of alcoholic hepatitis.		mm9_circ_018725			alcoholic hepatitis / AH	MONDO:0001505	alcoholic hepatitis	dysregulated	RT-qPCR; RNA-seq	"mm9_circ_018725 is a significantly differentially expressed mouse circRNA identified in liver tissues from an EtOH-induced alcoholic hepatitis model. Functional knockdown experiments indicate that it contributes to EtOH-induced hepatocyte apoptosis and promotes inflammatory cytokine production in Raw264.7 cells, making it a potential molecular target for alcoholic hepatitis."	0.5067
31494761	"Medical oncology (Northwood, London, England)"	2019	Circular RNA expression and circPTPRM promotes proliferation and migration in hepatocellular carcinoma.	hsa_circ_0007144	circRNA PTPRM / circPTPRM	hsa_circ_PTPRM	PTPRM	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circPTPRM is significantly upregulated in human HCC tissues and hepatoma cell lines. Its high expression is associated with recurrence and metastasis, and silencing circPTPRM suppresses HCC cell proliferation, migration and invasion in vitro. The authors further predicted a ceRNA-related mechanism and hypothesized possible regulation involving its parental gene PTPRM, but these mechanisms were not experimentally confirmed."	0.6719
31494761	"Medical oncology (Northwood, London, England)"	2019	Circular RNA expression and circPTPRM promotes proliferation and migration in hepatocellular carcinoma.	hsa_circ_0000847	circSMAD2	hsa_circ_SMAD2	SMAD2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circSMAD2 was selected from RNA-seq data as an upregulated circRNA and was validated by qRT-PCR as significantly higher in HCC tissues than paired adjacent non-tumorous liver tissues. Its expression was associated with TNM stage, but the study did not perform circSMAD2-specific functional or mechanistic assays."	0.3588
31495936	Annals of the New York Academy of Sciences	2020	Fucoidan affects oral squamous cell carcinoma cell functions in vitro by regulating FLNA-derived circular RNA.		circFLNA	hsa_circ_FLNA	FLNA	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR	"This study found that circFLNA is downregulated in OSCC tissues and cell lines. Fucoidan upregulated circFLNA, and both fucoidan and circFLNA suppressed OSCC cell proliferation, promoted apoptosis, and inhibited migration and invasion, indicating a circFLNA-mediated antitumor effect."	0.5442
31501232	"Clinical science (London, England : 1979)"	2019	Circ-0000284 arouses malignant phenotype of cholangiocarcinoma cells and regulates the biological functions of peripheral cells through cellular communication.	hsa_circ_0000284	circ-0000284	hsa_circ_HIPK3	HIPK3	Cholangiocarcinoma / CCA	MONDO:0019087	cholangiocarcinoma	up-regulated	RT-qPCR	"circ-0000284 is up-regulated in cholangiocarcinoma cell lines, tumor tissues and plasma exosomes. It promotes cholangiocarcinoma cell proliferation, migration, invasion, tumor growth and metastasis while inhibiting apoptosis through the miR-637/LY6E ceRNA axis. Exosome-transmitted circ-0000284 can also be delivered to surrounding normal cells and promote malignant-like cellular behaviors."	0.8511
31502887	Genetic testing and molecular biomarkers	2019	Screening for Differentially Expressed Circular RNAs in the Cartilage of Osteoarthritis Patients for Their Diagnostic Value.	hsa_circ_0032131	hsa_circ_0032131_CBC1	hsa_circ_PRKCH	PRKCH	Osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_0032131 was up-regulated in osteoarthritis chondrocytes and its expression change was consistent between microarray and qRT-PCR validation. The study proposed that it may participate in OA initiation and progression and may serve as a diagnostic biomarker, potentially through predicted circRNA-miRNA sponge interactions."	0.4032
31504797	Neuro-oncology	2019	CircFOXO3 promotes glioblastoma progression by acting as a competing endogenous RNA for NFAT5.	hsa_circ_0006404	CircFOXO3	hsa_circ_FOXO3	FOXO3	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR	"circFOXO3 (hsa_circ_0006404) is up-regulated in GBM tissues and GBM cell lines. It promotes GBM proliferation, invasion, migration, and xenograft tumor growth by acting as a cytoplasmic ceRNA that sponges miR-138-5p and miR-432-5p to increase NFAT5 expression. High circFOXO3 expression is associated with tumor size, histologic grade, IDH status, and MGMT methylation status, supporting its potential as a therapeutic target."	0.8689
31521692	Life sciences	2019	Downregulation of circular RNA circ-LDLRAD3 suppresses pancreatic cancer progression through miR-137-3p/PTN axis.	hsa_circ_0006988	circ-LDLRAD3	hsa_circ_LDLRAD3	LDLRAD3	pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"circ-LDLRAD3 is up-regulated in pancreatic cancer tissues and cell lines, and high expression is associated with poor overall survival. Functionally, circ-LDLRAD3 promotes pancreatic cancer cell proliferation, migration, invasion and xenograft tumor growth by sponging miR-137-3p and regulating PTN expression."	0.8005
31522588	"Cell cycle (Georgetown, Tex.)"	2019	"Circ_0015756 promotes proliferation, invasion and migration by microRNA-7-dependent inhibition of FAK in hepatocellular carcinoma."	hsa_circ_0015756	circ_0015756			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0015756 is up-regulated in HCC tissues and cell lines. Functionally, it promotes HCC proliferation, migration, invasion, tumor growth and intrahepatic metastasis while suppressing apoptosis. Mechanistically, circ_0015756 sponges miR-7 to relieve repression of FAK and activate the Akt-related pro-metastatic program involving Snail-1, Slug and MMP-9."	0.6544
31525642	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2019	Hsa_circ_0042666 inhibits proliferation and invasion via regulating miR-223/TGFBR3 axis in laryngeal squamous cell carcinoma.	hsa_circ_0042666		hsa_circ_SUPT6H	SUPT6H	laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	down-regulated	RT-qPCR	"hsa_circ_0042666 is downregulated in LSCC and appears to function as a tumor suppressor. It inhibits LSCC cell proliferation and invasion by sponging miR-223 and regulating TGFBR3 expression through the hsa_circ_0042666/miR-223/TGFBR3 axis. Clinically, low hsa_circ_0042666 expression is associated with advanced tumor stage, lymph-node metastasis, and poor overall survival."	0.7779
31526191	Genetic testing and molecular biomarkers	2019	Preliminary Exploration of hsa_circ_0032131 Levels in Peripheral Blood as a Potential Diagnostic Biomarker of Osteoarthritis.	hsa_circ_0032131	hsa_circ_0032131_CBC1	hsa_circ_PRKCH	PRKCH	Osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0032131_CBC1 is up-regulated in the peripheral blood of osteoarthritis patients and was validated by qRT-PCR, consistent with previous microarray findings in chondrocytes. It showed potential diagnostic utility for OA with an AUC of 0.8455, while its predicted miRNA interactions and relationship with PRKCH remain exploratory."	0.5047
31542615	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2019	Downregulation of CircRNA CDR1as specifically triggered low-dose Diosbulbin-B induced gastric cancer cell death by regulating miR-7-5p/REGgamma axis.		CircRNA CDR1as	hsa_circ_CDR1as		gastric cancer / GC	MONDO:0001056	gastric cancer	unknown	RT-qPCR	"This in vitro study shows that CircRNA CDR1as supports gastric cancer cell survival under low-dose Diosbulbin-B treatment. Knock-down of CircRNA CDR1as enhances low-dose DB-induced inhibition of proliferation and induction of apoptosis in GC cells through the miR-7-5p/REGgamma axis, suggesting CDR1as as a potential target to improve DB-based GC therapy."	0.5607
31545253	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2019	Upregulated circ_0005576 facilitates cervical cancer progression via the miR-153/KIF20A axis.	hsa_circ_0005576	circ_0005576			cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"circ_0005576 is upregulated in cervical cancer tissues and cell lines and its high expression is associated with advanced FIGO stage, lymph node metastasis and poor overall survival. Functionally, circ_0005576 promotes cervical cancer cell proliferation, migration, invasion and in vivo tumor growth. Mechanistically, it is mainly cytoplasmic and promotes KIF20A expression by sponging miR-153-3p."	0.8226
31549406	Journal of cellular physiology	2020	Circular RNA hsa_circ_0053277 promotes the development of colorectal cancer by upregulating matrix metallopeptidase 14 via miR-2467-3p sequestration.	hsa_circ_0053277	circ_0053277	hsa_circ_NRBP1	NRBP1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0053277 is up-regulated in colorectal cancer tissues and cells. It promotes CRC cell proliferation, migration, and EMT by acting as a miR-2467-3p sponge to increase MMP14 expression, suggesting potential therapeutic relevance."	0.8203
31570791	Oncogene	2020	NUDT21 regulates circRNA cyclization and ceRNA crosstalk in hepatocellular carcinoma.	hsa_circ_0007874				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Northern Blot; RNA-seq; Microarray	"hsa_circ_0007874 is a NUDT21 target circRNA downregulated in HCC-related datasets and NUDT21-knockdown HCC cells. It acts as a ceRNA for miR-9 to relieve repression of CDX2, and its overexpression suppresses NUDT21 knockdown-induced HCC cell growth and colony formation."	0.623
31570791	Oncogene	2020	NUDT21 regulates circRNA cyclization and ceRNA crosstalk in hepatocellular carcinoma.	hsa_circ_0004913				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Northern Blot; RNA-seq; Microarray	"hsa_circ_0004913 is a NUDT21 target circRNA selected as downregulated in HCC-related datasets and NUDT21-knockdown HCC cells. It participates in a ceRNA pathway by antagonizing miR-184-mediated silencing of INPPL1, and NUDT21 knockdown disrupts this circRNA-miRNA-mRNA crosstalk."	0.5777
31570856	Cell death and differentiation	2020	Splicing factor derived circular RNA circUHRF1 accelerates oral squamous cell carcinoma tumorigenesis via feedback loop.	hsa_circ_0002185	circUHRF1	hsa_circ_UHRF1	UHRF1	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circUHRF1 is an upregulated oncogenic circRNA in OSCC cells and tissues, and high expression is associated with poor patient survival. It promotes proliferation, migration, invasion, EMT and xenograft tumor growth by sponging miR-526b-5p to increase c-Myc, which activates TGF-beta1 and ESRP1 transcription; ESRP1 further enhances circUHRF1 biogenesis, forming a positive feedback loop."	0.8953
31593800	Cancer letters	2020	Reduction of circular RNA Foxo3 promotes prostate cancer progression and chemoresistance to docetaxel.	hsa_circ_0006404	circular RNA Foxo3 / circFoxo3 	hsa_circ_Foxo3	Foxo3	prostate cancer / PCa	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR	"circFoxo3 is down-regulated in high-grade prostate cancer tissues and more invasive prostate cancer cell lines. Functionally, circFoxo3 suppresses prostate cancer cell survival, migration, invasion, EMT and docetaxel chemoresistance, while promoting apoptosis and chemosensitivity in xenograft-bearing mice. Mechanistically, circFoxo3 appears to sponge miRNAs targeting Foxo3 to enhance Foxo3 protein translation and repress EMT."	0.8322
31595500	Journal of cellular physiology	2020	"The circ_0021977/miR-10b-5p/P21 and P53 regulatory axis suppresses proliferation, migration, and invasion in colorectal cancer."	hsa_circ_0021977	circ_0021977	hsa_circ_PSMC3	PSMC3	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"circ_0021977 is a human PSMC3-derived circRNA that is downregulated in CRC tissues, plasma, and cell lines. It suppresses CRC proliferation, migration, invasion, and xenograft tumor growth by sponging miR-10b-5p and indirectly increasing P21/P53 expression. Clinically, low circ_0021977 expression is associated with lymph node metastasis, advanced TNM stage, poorer prognosis, and diagnostic potential in plasma."	0.8844
31596149	Scandinavian journal of clinical and laboratory investigation	2019	Aberrant dysregulated circular RNAs in the peripheral blood mononuclear cells of patients with rheumatoid arthritis revealed by RNA sequencing: novel diagnostic markers for RA.	hsa_circ_0000396		hsa_circ_SLC38A1	SLC38A1	rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000396 was significantly downregulated in PBMCs from RA patients compared with healthy controls, as shown by RNA-seq and validated by qRT-PCR. ROC analysis indicated diagnostic value for RA, and the authors highlighted it as a potential diagnostic biomarker."	0.5047
31596149	Scandinavian journal of clinical and laboratory investigation	2019	Aberrant dysregulated circular RNAs in the peripheral blood mononuclear cells of patients with rheumatoid arthritis revealed by RNA sequencing: novel diagnostic markers for RA.	hsa_circ_0130438		hsa_circ_KPNA5	KPNA5	rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0130438 was significantly downregulated in PBMCs from RA patients compared with healthy controls, consistent between RNA-seq and qRT-PCR validation. ROC analysis suggested diagnostic value for RA, but no mechanistic regulatory axis was experimentally defined."	0.5047
31597523	Cancer biology & therapy	2020	Circular RNA HIPK3 induces cell proliferation and inhibits apoptosis in non-small cell lung cancer through sponging miR-149.		circRNA-HIPK3	hsa_circ_HIPK3	HIPK3	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"This study reports that circHIPK3 is up-regulated in NSCLC tissues and cell lines. Functionally, circHIPK3 promotes NSCLC cell proliferation, migration, invasion, tumor growth and metastasis, while its knockdown suppresses these malignant phenotypes. Mechanistically, circHIPK3 acts through a miR-149/FOXM1 regulatory axis and is proposed as a potential biomarker and therapeutic target for NSCLC."	0.8168
31598673	Journal of biochemistry	2020	Circ_0000218 plays a carcinogenic role in colorectal cancer progression by regulating miR-139-3p/RAB1A axis.	hsa_circ_0000218	circ_0000218			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0000218 is up-regulated in colorectal cancer tissues and cell lines and is associated with increased T stage and lymph node metastasis. Functionally, circ_0000218 promotes CRC cell proliferation, migration, invasion, metastasis and EMT. Mechanistically, it acts through the miR-139-3p/RAB1A axis by sponging miR-139-3p and increasing RAB1A expression."	0.7537
31599823	Neuroreport	2019	Knockdown of circular RNA CEP128 suppresses proliferation and improves cytotoxic efficacy of temozolomide in glioma cells by regulating miR-145-5p.	hsa_circ_0102722	Circular RNA CEP128 / circCEP128	hsa_circ_CEP128	CEP128	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circCEP128 is up-regulated in glioma tissues, glioma cell lines, and TMZ-resistant glioma cells. Functionally, circCEP128 promotes glioma cell proliferation and temozolomide resistance, while its knockdown suppresses proliferation and enhances TMZ cytotoxicity. Mechanistically, circCEP128 acts as a miR-145-5p sponge and regulates ABCG2 expression, suggesting therapeutic potential for overcoming TMZ resistance."	0.6996
31606623	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2019	Hsa_circ_0070269 inhibits hepatocellular carcinoma progression through modulating miR-182/NPTX1 axis.	hsa_circ_0070269		hsa_circ_BMPER	BMPER	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0070269 is down-regulated in HCC tissues and cell lines, and low expression is associated with aggressive clinicopathological features and poor prognosis. Functionally, hsa_circ_0070269 suppresses HCC proliferation, invasion, and xenograft tumor growth. Mechanistically, it acts as a cytoplasmic miR-182 sponge to increase NPTX1 expression, forming a hsa_circ_0070269/miR-182/NPTX1 tumor-suppressive axis."	0.7855
31607209	"Cell cycle (Georgetown, Tex.)"	2019	The circular RNA ZNF292 alleviates OGD-induced injury in H9c2 cells via targeting BNIP3.		circular RNA ZNF292 / circZNF292	rno_circ_ZNF292	ZNF292	myocardial ischemic	MONDO:0024644	myocardial ischemia	up-regulated	RT-qPCR	"In an in vitro H9c2 oxygen-glucose deprivation model of myocardial ischemic injury, circZNF292 was up-regulated and exerted a protective role. Its overexpression improved cell viability and reduced apoptosis and autophagy, while silencing worsened OGD-induced injury. Mechanistically, circZNF292 negatively regulated BNIP3 and activated Wnt/beta-catenin and mTOR signaling."	0.414
31607223	RNA biology	2020	circDLPAG4/HECTD1 mediates ischaemia/reperfusion injury in endothelial cells via ER stress.		circDLPAG4	hsa_circ_DLGAP4	DLGAP4	ischemia/reperfusion injury	MONDO:0005203	ischemia reperfusion injury	down-regulated	RT-qPCR; ISH	"circDLGAP4 is down-regulated in endothelial cells after I/R exposure. It regulates HECTD1 protein expression by sponging miR-143 and lies upstream of ER stress-related endothelial dysfunction. Functionally, circDLGAP4 overexpression attenuates I/R-induced endothelial migration and PYK2 upregulation, but does not rescue I/R-induced loss of viability or apoptosis."	0.6093
31608699	"Artificial cells, nanomedicine, and biotechnology"	2019	Circ_0026344 restrains metastasis of human colorectal cancer cells via miR-183.	hsa_circ_0026344	circ_0026344			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"In human CRC cell lines, CCL20 and CXCL8 co-stimulation down-regulated circ_0026344. Functional experiments showed that circ_0026344 suppresses CRC cell migration, invasion, metastasis-related EMT, and Wnt/b-catenin signaling, at least partly through negative regulation of miR-183."	0.3957
31609809	European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)	2020	Circular RNA Pleiotrophin promotes carcinogenesis in glioma via regulation of microRNA-122/SRY-box transcription factor 6 axis.		circRNA_PTN / circular RNA pleiotrophin	hsa_circ_PTN	pleiotrophin	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"Circ_PTN is up-regulated in human glioma cell lines and functions as an oncogenic circRNA. It promotes glioma cell proliferation and cell-cycle progression while suppressing apoptosis by sponging miR-122, thereby increasing SOX6 expression and activating MAPK/ERK-related signaling."	0.5607
31625175	Journal of cellular biochemistry	2020	Exosome circ_0044516 promotes prostate cancer cell proliferation and metastasis as a potential biomarker.	hsa_circ_0044516	circ_0044516			prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0044516/circ_0044516 is upregulated in prostate cancer exosomes, tissues and cell lines. It promotes prostate cancer cell proliferation and metastatic behaviors, at least partly by acting as a sponge for miR-29a-3p, and may serve as a potential biomarker."	0.7404
31625175	Journal of cellular biochemistry	2020	Exosome circ_0044516 promotes prostate cancer cell proliferation and metastasis as a potential biomarker.	hsa_circ_0072034	circ_0072034			prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	circ_0072034 was identified by microarray and confirmed by qRT-PCR as upregulated in blood exosomes from prostate cancer patients. No specific functional mechanism was reported for this circRNA.	0.4773
31625175	Journal of cellular biochemistry	2020	Exosome circ_0044516 promotes prostate cancer cell proliferation and metastasis as a potential biomarker.	hsa_circ_0041972	circ_0041972			prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	circ_0041972 was identified by microarray and confirmed by qRT-PCR as upregulated in blood exosomes from prostate cancer patients. No specific functional mechanism was reported for this circRNA.	0.4773
31625175	Journal of cellular biochemistry	2020	Exosome circ_0044516 promotes prostate cancer cell proliferation and metastasis as a potential biomarker.	hsa_circ_0081234	circ_0081234			prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	circ_0081234 was identified by microarray and confirmed by qRT-PCR as upregulated in blood exosomes from prostate cancer patients. No specific functional mechanism was reported for this circRNA.	0.4773
31625175	Journal of cellular biochemistry	2020	Exosome circ_0044516 promotes prostate cancer cell proliferation and metastasis as a potential biomarker.	hsa_circ_0009865	circ_0009865			prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	circ_0009865 was identified by microarray and confirmed by qRT-PCR as upregulated in blood exosomes from prostate cancer patients. No specific functional mechanism was reported for this circRNA.	0.4773
31625175	Journal of cellular biochemistry	2020	Exosome circ_0044516 promotes prostate cancer cell proliferation and metastasis as a potential biomarker.	hsa_circ_0017649	circ_0017649			prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	circ_0017649 was identified by microarray and confirmed by qRT-PCR as upregulated in blood exosomes from prostate cancer patients. No specific functional mechanism was reported for this circRNA.	0.4773
31625175	Journal of cellular biochemistry	2020	Exosome circ_0044516 promotes prostate cancer cell proliferation and metastasis as a potential biomarker.	hsa_circ_0012098	circ_0012098			prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	circ_0012098 was identified by microarray and confirmed by qRT-PCR as upregulated in blood exosomes from prostate cancer patients. No specific functional mechanism was reported for this circRNA.	0.4773
31625175	Journal of cellular biochemistry	2020	Exosome circ_0044516 promotes prostate cancer cell proliferation and metastasis as a potential biomarker.	hsa_circ_0021601	circ_0021601			prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	circ_0021601 was identified by microarray and confirmed by qRT-PCR as upregulated in blood exosomes from prostate cancer patients. No specific functional mechanism was reported for this circRNA.	0.4773
31629934	Cancer letters	2020	CircRNA cRAPGEF5 inhibits the growth and metastasis of renal cell carcinoma via the miR-27a-3p/TXNIP pathway.	hsa_circ_0001681	CircRNA RAPGEF5 / cRAPGEF5	hsa_circ_RAPGEF5	RAPGEF5	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	down-regulated	RT-qPCR	"cRAPGEF5 is a human RAPGEF5-derived circRNA that is significantly downregulated in RCC tissues. It acts as a tumor suppressor by sponging miR-27a-3p and preventing TXNIP downregulation, thereby inhibiting RCC cell proliferation, migration, invasion, tumor growth and metastasis. Clinically, reduced cRAPGEF5 expression is associated with aggressive features and poor OS/RFS, suggesting prognostic and therapeutic potential."	0.8912
31637615	Environmental science and pollution research international	2019	Differentially expressed circular RNAs in air pollution-exposed rat embryos.		circ_015003			air pollution-associated congenital malformations	MONDO:0000001	disease	dysregulated	RNA-seq	"This circRNA was among the centrally connected circRNAs in the predicted circRNA-miRNA network, identified in air pollution-exposed rat embryos. The study suggests it may be part of the circRNA deregulation associated with congenital defect development, but no circRNA-specific downstream target or validated mechanism was reported."	0.2414
31637615	Environmental science and pollution research international	2019	Differentially expressed circular RNAs in air pollution-exposed rat embryos.		circ_030724			air pollution-associated congenital malformations	MONDO:0000001	disease	dysregulated	RNA-seq	"This circRNA was one of the centrally connected circRNAs in the predicted circRNA-miRNA network. The study suggests it may be part of the circRNA deregulation associated with congenital defect development, but no circRNA-specific downstream target or validated mechanism was reported."	0.2414
31637615	Environmental science and pollution research international	2019	Differentially expressed circular RNAs in air pollution-exposed rat embryos.		circ_127215			air pollution-associated congenital malformations	MONDO:0000001	disease	dysregulated	RNA-seq	"This circRNA was one of the centrally connected circRNAs in the predicted circRNA-miRNA network. The study suggests it may be part of the circRNA deregulation associated with congenital defect development, but no circRNA-specific downstream target or validated mechanism was reported."	0.2414
31637704	Journal of cellular physiology	2020	Circular RNA circFNDC3B protects renal carcinoma by miR-99a downregulation.		circRNA circFNDC3B / circFNDC3B	hsa_circ_FNDC3B	FNDC3B	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR	"circFNDC3B is up-regulated in renal carcinoma tissues and promotes malignant phenotypes in ACHN and CAKI-1 cells, including viability, colony formation and migration. Mechanistically, circFNDC3B negatively regulates miR-99a and enhances JAK1/STAT3 and MEK/ERK signaling pathway activity."	0.6261
31638251	Oncology reports	2019	Microarray profile of circular RNAs identifies hsa_circRNA_102459 and hsa_circRNA_043621 as important regulators in oral squamous cell carcinoma.		hsa_circRNA_102459	hsa_circ_MAST1	MAST1	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_102459 is down-regulated in OSCC and is proposed to act as a tumor-suppressive circRNA. Its overexpression inhibits TSCC1 cell proliferation, arrests the cell cycle at G0/G1, promotes apoptosis, and suppresses MAPK and PI3K/Akt signaling; its expression is also associated with clinical stage, tumor differentiation, and lymph node metastasis."	0.7295
31638251	Oncology reports	2019	Microarray profile of circular RNAs identifies hsa_circRNA_102459 and hsa_circRNA_043621 as important regulators in oral squamous cell carcinoma.		hsa_circRNA_043621	hsa_circ_KRT14	KRT14	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_043621 is up-regulated in OSCC and is proposed to act as a tumor-promoting circRNA. Its knockdown suppresses TSCC1 cell proliferation, arrests the cell cycle at G0/G1, promotes apoptosis, and suppresses MAPK and PI3K/Akt signaling; its expression is also associated with clinical stage, tumor differentiation, and lymph node metastasis."	0.7295
31640088	Cancer biomarkers : section A of Disease markers	2019	Identification of hsa_circ_0005654 as a new early biomarker of gastric cancer.	hsa_circ_0005654		hsa_circ_PRDM5	PRDM5	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"This study found that hsa_circ_0005654 is significantly down-regulated in early gastric cancer mucosae compared with matched adjacent nontumor mucosae and healthy gastric mucosa samples. Its diagnostic performance was evaluated by ROC analysis, with AUCs of 0.927 and 0.924, supporting its potential use as an early diagnostic biomarker for gastric cancer."	0.5958
31643077	Journal of cellular physiology	2020	Circular RNA circ_0074026 indicates unfavorable prognosis for patients with glioma and facilitates oncogenesis of tumor cells by targeting miR-1304 to modulate ERBB4 expression.	hsa_circ_0074026	circ_0074026	hsa_circ_PITX1	PITX1	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ_0074026 is up-regulated in glioma tissues and cell lines, and high expression predicts unfavorable prognosis. Functionally, circ_0074026 promotes glioma cell proliferation, migration and invasion while inhibiting apoptosis. Mechanistically, it sponges miR-1304 to upregulate ERBB4 expression and thereby facilitates glioma progression."	0.7126
31643094	Journal of cellular physiology	2020	Circular RNA circC3P1 restrains kidney cancer cell activity by regulating miR-21/PTEN axis and inactivating PI3K/AKT and NF- kB pathways.		Circular RNA C3P1 / circC3P1	hsa_circ_C3P1	C3P1	kidney cancer / KC	MONDO:0002367	kidney cancer	down-regulated	RT-qPCR	"circC3P1 is downregulated in kidney cancer tissues and functions as a tumor suppressor in KC cells. Its overexpression reduces cell viability, migration, and invasion, induces apoptosis, negatively regulates miR-21, restores PTEN expression, and inhibits PI3K/AKT and NF-kappaB signaling pathways."	0.6261
31646690	Journal of cellular biochemistry	2020	Circular RNAs expression profiles in plasma exosomes from early-stage lung adenocarcinoma and the potential biomarkers.	hsa_circ_0001492	circ_0001492			lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001492 was significantly upregulated in plasma exosomes from early-stage LUAD patients and validated by qRT-PCR, RNase R treatment, and Sanger sequencing. The study suggests it may serve as a potential early diagnostic biomarker and explored its predicted circRNA-miRNA-mRNA regulatory network."	0.585
31646690	Journal of cellular biochemistry	2020	Circular RNAs expression profiles in plasma exosomes from early-stage lung adenocarcinoma and the potential biomarkers.	hsa_circ_0001346	circ_0001346			lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001346 was significantly upregulated in plasma exosomes from early-stage LUAD patients and validated by qRT-PCR, RNase R treatment, and Sanger sequencing. The study suggests it may serve as a potential early diagnostic biomarker and explored its predicted circRNA-miRNA-mRNA regulatory network."	0.585
31646690	Journal of cellular biochemistry	2020	Circular RNAs expression profiles in plasma exosomes from early-stage lung adenocarcinoma and the potential biomarkers.	hsa_circ_0000690	circ_0000690	hsa_circ_ITGAL	ITGAL	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000690, derived from ITGAL, was significantly upregulated in plasma exosomes from early-stage LUAD patients and validated by qRT-PCR, RNase R treatment, and Sanger sequencing. The study proposes it as a potential biomarker and predicts a circRNA-miRNA-mRNA regulatory network for its possible function."	0.585
31646690	Journal of cellular biochemistry	2020	Circular RNAs expression profiles in plasma exosomes from early-stage lung adenocarcinoma and the potential biomarkers.	hsa_circ_0001439	circ_0001439			lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001439 was significantly upregulated in plasma exosomes from early-stage LUAD patients and validated by qRT-PCR, RNase R treatment, and Sanger sequencing. The study proposes it as a potential biomarker and predicts a circRNA-miRNA-mRNA regulatory network for its possible function."	0.585
31647948	Life sciences	2019	Circ_0076305 regulates cisplatin resistance of non-small cell lung cancer via positively modulating STAT3 by sponging miR-296-5p.	hsa_circ_0076305	circ_0076305			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"This study reports that circ_0076305 is up-regulated in NSCLC tissues and DDP-resistant NSCLC contexts. Functionally, circ_0076305 promotes cisplatin resistance in NSCLC cells. Mechanistically, it acts as a miR-296-5p sponge to positively regulate STAT3 expression, forming a circ_0076305/miR-296-5p/STAT3 axis related to DDP resistance."	0.7475
31665272	Pathogens and disease	2019	Identification of differentially expressed circular RNAs in HeLa cells infected with Chlamydia trachomatis.		hsa_circRNA_001226	hsa_circ_MYH9	MYH9	Chlamydia trachomatis infection	MONDO:0005701	chlamydia trachomatis infectious disease	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_001226 is upregulated in Chlamydia trachomatis-infected HeLa cells. The authors suggest it may function as a miRNA sponge in a circRNA/miRNA/mRNA regulatory network, potentially affecting Rab11A-related host-pathogen interactions and promoting Chlamydia survival."	0.2465
31665272	Pathogens and disease	2019	Identification of differentially expressed circular RNAs in HeLa cells infected with Chlamydia trachomatis.		hsa_circRNA_007046	hsa_circ_GFPT1	GFPT1	Chlamydia trachomatis infection	MONDO:0005701	chlamydia trachomatis infectious disease	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_007046 is upregulated in Chlamydia trachomatis-infected HeLa cells. It is proposed to participate in a circRNA/miRNA/mRNA axis involving hsa-miR-608 and Rab25/Rab11c, potentially affecting host-pathogen interaction and Chlamydia survival."	0.2465
31665272	Pathogens and disease	2019	Identification of differentially expressed circular RNAs in HeLa cells infected with Chlamydia trachomatis.		hsa_circRNA_400027	hsa_circ_SNURF-S NRPN	SNURF-S NRPN	Chlamydia trachomatis infection	MONDO:0005701	chlamydia trachomatis infectious disease	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_400027 is upregulated in Chlamydia trachomatis-infected HeLa cells. It is proposed to function through a hsa-miR-613/BDNF/MAPK-related ceRNA axis, potentially contributing to host-cell changes that favor Chlamydia survival."	0.2465
31667786	Human cell	2020	Circ_ANKIB1 stabilizes the regulation of miR-19b on SOCS3/STAT3 pathway to promote osteosarcoma cell growth and invasion.	hsa_circ_0009112	circ_ANKIB1	hsa_circ_ANKIB1		osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ_ANKIB1 is up-regulated in human osteosarcoma cell lines and mainly localizes in the cytoplasm. It binds miR-19b and enhances miR-19b-mediated suppression of SOCS3, thereby activating the STAT3/JAK-STAT pathway. Functionally, circ_ANKIB1 promotes osteosarcoma cell proliferation and invasion while inhibiting apoptosis."	0.6853
31668372	Biochemical and biophysical research communications	2020	Hsa_circ_0001546 acts as a miRNA-421 sponge to inhibit the chemoresistance of gastric cancer cells via ATM/Chk2/p53-dependent pathway.	hsa_circ_0001546	circ_0001546	hsa_circ_FAM114A2	FAM114A2	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"hsa_circ_0001546 is downregulated in gastric cancer tissues, plasma before tumor removal, and gastric cancer cell lines, and lower expression is associated with shorter overall survival. It functions as a miR-421 sponge, increases ATM expression, activates the ATM/Chk2/p53 pathway, suppresses proliferation and chemoresistance, and enhances L-OHP-induced apoptosis."	0.8461
31668923	Biochemical and biophysical research communications	2020	"A novel circular RNA, hsa-circ-0000211, promotes lung adenocarcinoma migration and invasion through sponging of hsa-miR-622 and modulating HIF1-alpha expression."	hsa_circ_0000211	hsa_-circ_000524	hsa_circ_SFMBT2	SFMBT2	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"hsa-circ-0000211 is up-regulated in lung adenocarcinoma tissues and cell lines. It promotes LAC cell migration and invasion by sponging miR-622 and increasing HIF1A/HIF1-a expression, and its expression is positively associated with distant metastasis, suggesting potential therapeutic relevance."	0.7759
31669510	Clinical biochemistry	2019	Plasma circular RNA panel acts as a novel diagnostic biomarker for colorectal cancer.		circ-CCDC66	hsa_circ_CCDC66	CCDC66	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"circ-CCDC66 was significantly decreased in plasma from CRC patients and was included in a three-circRNA diagnostic panel. It also showed diagnostic value for early-stage CRC, CEA-negative/CA19-9-negative CRC, precursor lesions, and postoperative improvement prediction."	0.6291
31669510	Clinical biochemistry	2019	Plasma circular RNA panel acts as a novel diagnostic biomarker for colorectal cancer.		circ-ABCC1	hsa_circ_ABCC1	ABCC1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"circ-ABCC1 was significantly decreased in plasma from CRC patients and was included in a three-circRNA diagnostic panel. Lower plasma circ-ABCC1 was associated with higher tumor stage, tumor burden, lymph node metastasis and distant metastasis, and it was also decreased in CRC precursor lesions."	0.6291
31669510	Clinical biochemistry	2019	Plasma circular RNA panel acts as a novel diagnostic biomarker for colorectal cancer.		circ-STIL	hsa_circ_STIL	STIL	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	circ-STIL was significantly decreased in plasma from CRC patients and was included in a three-circRNA diagnostic panel. It showed diagnostic value for early-stage CRC and for CRC patients with normal CEA or CA19-9 levels.	0.6291
31669576	Life sciences	2019	Silencing circular RNA hsa_circ_0004491 promotes metastasis of oral squamous cell carcinoma.	hsa_circ_0004491	circ_0004491	hsa_circ_ORC4	ORC4	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0004491 is a human ORC4-derived circRNA downregulated in OSCC tissues and cell lines. Low expression is associated with lymph node metastasis and loss of hsa_circ_0004491 promotes OSCC migration, invasion, and EMT-like marker changes, while overexpression suppresses these malignant phenotypes. The study suggests hsa_circ_0004491 may serve as a diagnostic/metastasis-related biomarker and may act partly through miRNA-related regulation, especially involving hsa-miR-155-5p."	0.7078
31669641	Gene	2020	Next-generation sequencing reveals hsa_circ_0058092 being a potential oncogene candidate involved in gastric cancer.	hsa_circ_0058092		hsa_circ_FN1	FN1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0058092 is an up-regulated circRNA in gastric cancer and was selected as a potential oncogene candidate. The study suggests that it may act as a ceRNA for hsa-miR-4269 to influence PODXL, and its high expression is associated with invasion and poorer patient survival."	0.6257
31669648	Gene	2020	Circ-EZH2 knockdown reverses DDAH1 and CBX3-mediated cell growth and invasion in glioma through miR-1265 sponge activity.	hsa_circ_0082846	circ-EZH2	hsa_circ_EZH2	EZH2	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"Circ-EZH2 is upregulated in glioma tissues and cell lines and acts as an oncogenic circRNA. It promotes glioma cell proliferation, migration and invasion and inhibits apoptosis through a ceRNA mechanism involving miR-1265-mediated regulation of DDAH1 and CBX3."	0.6536
31672718	Journal of investigative medicine : the official publication of the American Federation for Clinical Research	2020	Detection of a 5-circRNA signature to improve prognostic prediction in gastric cancer.	hsa_circ_0103398				gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0103398 was identified as one component of a 5-circRNA prognostic signature in gastric cancer. It was experimentally validated by real-time PCR as upregulated in GC tissues, associated with late TNM stage, and high expression predicted unfavorable survival."	0.5534
31672718	Journal of investigative medicine : the official publication of the American Federation for Clinical Research	2020	Detection of a 5-circRNA signature to improve prognostic prediction in gastric cancer.	hsa_circ_0119099				gastric cancer / GC	MONDO:0001056	gastric cancer	dysregulated	Microarray	"hsa_circ_0119099 was identified from reannotated microarray data as a differentially expressed circRNA significantly correlated with overall survival in gastric cancer. It was a risk-factor component of the 5-circRNA prognostic signature, but it was not individually validated by RT-qPCR in clinical tissues."	0.459
31672718	Journal of investigative medicine : the official publication of the American Federation for Clinical Research	2020	Detection of a 5-circRNA signature to improve prognostic prediction in gastric cancer.	hsa_circ_0121124				gastric cancer / GC	MONDO:0001056	gastric cancer	dysregulated	Microarray	"hsa_circ_0121124 was identified from reannotated microarray data as a differentially expressed circRNA significantly correlated with overall survival in gastric cancer. It was the protective-factor component of the 5-circRNA prognostic signature, but it was not individually validated by RT-qPCR in clinical tissues."	0.459
31672718	Journal of investigative medicine : the official publication of the American Federation for Clinical Research	2020	Detection of a 5-circRNA signature to improve prognostic prediction in gastric cancer.	hsa_circ_0127859				gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0127859 was identified as one component of a 5-circRNA prognostic signature in gastric cancer and was the only individual circRNA that significantly separated risk groups in the microarray training analysis. It was experimentally validated by real-time PCR as upregulated in GC tissues, associated with late TNM stage, and high expression predicted unfavorable survival."	0.5534
31672718	Journal of investigative medicine : the official publication of the American Federation for Clinical Research	2020	Detection of a 5-circRNA signature to improve prognostic prediction in gastric cancer.	hsa_circ_0139915				gastric cancer / GC	MONDO:0001056	gastric cancer	dysregulated	Microarray	"hsa_circ_0139915 was identified from reannotated microarray data as a differentially expressed circRNA significantly correlated with overall survival in gastric cancer. It was a risk-factor component of the 5-circRNA prognostic signature, but it was not individually validated by RT-qPCR in clinical tissues."	0.459
31678276	Clinica chimica acta; international journal of clinical chemistry	2020	Screening for differentially expressed circRNA between Kashin-Beck disease and osteoarthritis patients based on circRNA chips.	hsa_circ_0020014	hsa_circ_0020014_CBC1	hsa_circ_DUSP-5	DUSP-5	Kashin-Beck disease / KBD	MONDO:0005610	Kashin-Beck disease	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_0020014/hsa_circ_0020014_CBC1 was down-regulated between KBD and OA chondrocyte samples and was validated by qRT-PCR. It was further verified in peripheral blood and showed diagnostic potential for distinguishing KBD from OA, with predicted involvement in a circRNA-miRNA regulatory network."	0.5047
31678276	Clinica chimica acta; international journal of clinical chemistry	2020	Screening for differentially expressed circRNA between Kashin-Beck disease and osteoarthritis patients based on circRNA chips.	hsa_circ_0020014	hsa_circ_0020014_CBC1	hsa_circ_DUSP-5	DUSP-5	osteoarthritis / OA	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_0020014/hsa_circ_0020014_CBC1 was down-regulated between KBD and OA chondrocyte samples and was validated by qRT-PCR. It was further verified in peripheral blood and showed diagnostic potential for distinguishing KBD from OA, with predicted involvement in a circRNA-miRNA regulatory network."	0.5047
31678276	Clinica chimica acta; international journal of clinical chemistry	2020	Screening for differentially expressed circRNA between Kashin-Beck disease and osteoarthritis patients based on circRNA chips.	hsa_circ_0032131	hsa_circ_0032131_CBC1			Kashin-Beck disease / KBD	MONDO:0005610	Kashin-Beck disease	down-regulated	RT-qPCR; Microarray	hsa_circ_0032131_CBC1 was identified as a down-regulated circRNA between KBD and OA cartilage samples and selected among five circRNAs for qRT-PCR validation. The paper linked it to PRKCH as a target gene but did not perform mechanistic functional experiments for this circRNA.	0.3588
31678276	Clinica chimica acta; international journal of clinical chemistry	2020	Screening for differentially expressed circRNA between Kashin-Beck disease and osteoarthritis patients based on circRNA chips.	hsa_circ_0032131	hsa_circ_0032131_CBC1			osteoarthritis / OA	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR; Microarray	hsa_circ_0032131_CBC1 was identified as a down-regulated circRNA between KBD and OA cartilage samples and selected among five circRNAs for qRT-PCR validation. The paper linked it to PRKCH as a target gene but did not perform mechanistic functional experiments for this circRNA.	0.3588
31678276	Clinica chimica acta; international journal of clinical chemistry	2020	Screening for differentially expressed circRNA between Kashin-Beck disease and osteoarthritis patients based on circRNA chips.	hsa_circ_0057421	hsa_circ_0057421_CBC1			Kashin-Beck disease / KBD	MONDO:0005610	Kashin-Beck disease	up-regulated	RT-qPCR; Microarray	"hsa_circ_0057421_CBC1 was the one up-regulated circRNA among the five selected circRNAs validated between KBD and OA cartilage samples. The paper linked it to col3a1 and protein digestion and absorption in the rationale for selection, but did not experimentally define its mechanism."	0.3588
31678276	Clinica chimica acta; international journal of clinical chemistry	2020	Screening for differentially expressed circRNA between Kashin-Beck disease and osteoarthritis patients based on circRNA chips.	hsa_circ_0057421	hsa_circ_0057421_CBC1			osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0057421_CBC1 was the one up-regulated circRNA among the five selected circRNAs validated between KBD and OA cartilage samples. The paper linked it to col3a1 and protein digestion and absorption in the rationale for selection, but did not experimentally define its mechanism."	0.3588
31678276	Clinica chimica acta; international journal of clinical chemistry	2020	Screening for differentially expressed circRNA between Kashin-Beck disease and osteoarthritis patients based on circRNA chips.	hsa_circ_0094742	hsa_circ_0094742_CBC1			Kashin-Beck disease / KBD	MONDO:0005610	Kashin-Beck disease	down-regulated	RT-qPCR; Microarray	"hsa_circ_0094742_CBC1 was identified as a down-regulated circRNA between KBD and OA cartilage samples and selected for qRT-PCR validation. It was predicted to combine with microRNA-17-5p, but the article did not provide direct mechanistic validation."	0.3588
31678276	Clinica chimica acta; international journal of clinical chemistry	2020	Screening for differentially expressed circRNA between Kashin-Beck disease and osteoarthritis patients based on circRNA chips.	hsa_circ_0094742	hsa_circ_0094742_CBC1			osteoarthritis / OA	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR; Microarray	"hsa_circ_0094742_CBC1 was identified as a down-regulated circRNA between KBD and OA cartilage samples and selected for qRT-PCR validation. It was predicted to combine with microRNA-17-5p, but the article did not provide direct mechanistic validation."	0.3588
31678276	Clinica chimica acta; international journal of clinical chemistry	2020	Screening for differentially expressed circRNA between Kashin-Beck disease and osteoarthritis patients based on circRNA chips.	hsa_circ_0134111	hsa_circ_0134111_CBC1			Kashin-Beck disease / KBD	MONDO:0005610	Kashin-Beck disease	down-regulated	RT-qPCR; Microarray	"hsa_circ_0134111_CBC1 was identified as a down-regulated circRNA between KBD and OA cartilage samples and selected for qRT-PCR validation. The study rationale linked its target gene PDE1C to calcium signaling, but no direct functional mechanism was experimentally validated."	0.3588
31678276	Clinica chimica acta; international journal of clinical chemistry	2020	Screening for differentially expressed circRNA between Kashin-Beck disease and osteoarthritis patients based on circRNA chips.	hsa_circ_0134111	hsa_circ_0134111_CBC1			osteoarthritis / OA	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR; Microarray	"hsa_circ_0134111_CBC1 was identified as a down-regulated circRNA between KBD and OA cartilage samples and selected for qRT-PCR validation. The study rationale linked its target gene PDE1C to calcium signaling, but no direct functional mechanism was experimentally validated."	0.3588
31680239	Journal of cellular physiology	2020	Circ_0080425 inhibits cell proliferation and fibrosis in diabetic nephropathy via sponging miR-24-3p and targeting fibroblast growth factor 11.	mmu_circ_0080425	circ_0080425			diabetic nephropathy / DN	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	circ_0080425 is up-regulated in streptozotocin-induced diabetic nephropathy mouse kidney and high-glucose-treated mouse mesangial cells. It promotes mesangial cell proliferation and fibrosis through a ceRNA mechanism in which it sponges miR-24-3p and releases FGF11 from miR-24-3p-mediated repression.	0.6278
31680314	Journal of cellular biochemistry	2020	Circular RNA circ-Foxo3 inhibits esophageal squamous cell cancer progression via the miR-23a/PTEN axis.		circ-Foxo3 / Circular RNA FOXO3	hsa_circ_FOXO3	FOXO3	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	RT-qPCR	"Circ-Foxo3 is downregulated in ESCC tissues and cell lines and acts as a tumor suppressor. Its overexpression inhibits ESCC proliferation, migration, invasion and xenograft tumor growth, induces apoptosis and G0/G1 arrest, and mechanistically sponges miR-23a to increase PTEN expression. Clinically, lower circ-Foxo3 expression is associated with TNM stage, suggesting potential biomarker and therapeutic relevance."	0.7133
31680319	Journal of cellular biochemistry	2020	"Circular RNA circ_0074027 indicates a poor prognosis for NSCLC patients and modulates cell proliferation, apoptosis, and invasion via miR-185-3p mediated BRD4/MADD activation."	hsa_circ_0074027	circ_0074027			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0074027 is up-regulated in NSCLC tissues and cell lines, and high expression is associated with advanced TNM stage, poorer differentiation, and worse overall survival. Functionally, circ_0074027 promotes proliferation, migration, and invasion while inhibiting apoptosis. Mechanistically, it acts as a ceRNA for miR-185-3p to increase BRD4 and MADD expression."	0.7628
31690252	Stroke	2020	Circulating Circular RNAs as Biomarkers for the Diagnosis and Prediction of Outcomes in Acute Ischemic Stroke.		circFUNDC1 / circular RNA FUNDC1	hsa_circ_FUNDC1	FUNDC1	ischemic stroke	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; Microarray	"circFUNDC1 was significantly elevated in plasma from AIS patients compared with healthy controls. Together with circPDS5B and circCDC14A, it showed potential utility as a circulating biomarker for AIS diagnosis and prediction of stroke outcome, and circRNA levels were positively correlated with infarct volume."	0.5534
31690252	Stroke	2020	Circulating Circular RNAs as Biomarkers for the Diagnosis and Prediction of Outcomes in Acute Ischemic Stroke.		circPDS5B / circular RNA PDS5B	hsa_circ_PDS5B	PDS5B	ischemic stroke	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; Microarray	circPDS5B was significantly elevated in plasma from AIS patients and positively correlated with infarct volume as part of a three-circRNA biomarker panel. Its elevation in plasma might be derived from increased levels in lymphocytes and granulocytes.	0.5534
31690252	Stroke	2020	Circulating Circular RNAs as Biomarkers for the Diagnosis and Prediction of Outcomes in Acute Ischemic Stroke.		circCDC14A / circular RNA CDC14A	hsa_circ_CDC14A	CDC14A	ischemic stroke	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; Microarray	"circCDC14A was significantly elevated in plasma from AIS patients and positively correlated with infarct volume as part of a three-circRNA biomarker panel. Its elevation in AIS was significant in granulocytes, suggesting granulocytes may contribute to increased circulating circCDC14A."	0.5534
31692056	Journal of cellular biochemistry	2020	The circular RNA-NRIP1 plays oncogenic roles by targeting microRNA-505 in the renal carcinoma cell lines.		circular RNA nuclear receptor-interacting protein 1 / circNRIP1	hsa_circ_NRIP1	NRIP1	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR	"circNRIP1 is up-regulated in renal tumor tissues and functions as an oncogenic circRNA in ACHN and CAKI-1 renal carcinoma cells. Knockdown of circNRIP1 suppresses cell viability, colony formation, migration, and AMPK/PI3K/AKT/mTOR signaling while promoting apoptosis, at least partly through upregulation of miR-505."	0.5434
31692058	Journal of cellular biochemistry	2020	Silencing circular RNA circANKRD36 remits lipopolysaccharide-induced inflammatory damage by regulating microRNA-15/MyD88.		circANKRD36	hsa_circ_ANKRD36	ANKRD36	Bedsore	MONDO:0004646	decubitus ulcer	up-regulated	RT-qPCR	"In an in vitro bedsore-related LPS-induced inflammatory damage model, circANKRD36 was upregulated in HaCaT cells. Knockdown of circANKRD36 alleviated inflammatory injury by improving viability and suppressing apoptosis, inflammatory cytokine production, ROS generation, and NF-kappaB activation, at least partly through regulation of the miR-15/MyD88 axis."	0.528
31698040	Molecular and cellular probes	2020	Circ_016719 plays a critical role in neuron cell apoptosis induced by I/R via targeting miR-29c/Map2k6.		circ_016719 / circRNA_016719			ischemic stroke	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR	"This study reports that mouse circ_016719 is up-regulated in hippocampal tissue and HT22 neurons after ischemia/reperfusion-like injury. Functionally, circ_016719 promotes neuronal apoptosis and autophagy and suppresses proliferation, at least partly by directly interacting with miR-29c to regulate Map2k6 and downstream p38/p53-related signaling."	0.6544
31698267	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2020	Circular RNA circ-FOXP1 induced by SOX9 promotes hepatocellular carcinoma progression via sponging miR-875-3p and miR-421.		circ-FOXP1	hsa_circ_FOXP1	FOXP1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circ-FOXP1 is up-regulated in HCC tissues, serum and cell lines and functions as an oncogenic circRNA. SOX9 induces circ-FOXP1 expression, while cytoplasmic circ-FOXP1 sponges miR-875-3p and miR-421 to elevate oncogenic targets including SOX9, promoting proliferation, invasion, tumor growth and poor prognosis. Serum circ-FOXP1 also shows diagnostic potential for distinguishing HCC patients from healthy controls."	0.8413
31701767	"Artificial cells, nanomedicine, and biotechnology"	2019	Circ-PRMT5 promotes gastric cancer progression by sponging miR-145 and miR-1304 to upregulate MYC.		circ-PRMT5	hsa_circ_PRMT5	PRMT5	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"Circ-PRMT5 is up-regulated in gastric cancer tissues and cell lines and high expression predicts poor overall survival. Functionally, it promotes GC cell proliferation, colony formation, migration, invasion and EMT while inhibiting apoptosis. Mechanistically, circ-PRMT5 sponges miR-145 and miR-1304 to upregulate MYC, forming a circ-PRMT5/miR-145/miR-1304/MYC oncogenic axis."	0.8143
31705065	Oncogene	2020	Hsa_circ_0001361 promotes bladder cancer invasion and metastasis through miR-491-5p/MMP9 axis.	hsa_circ_0001361	circ0001361	hsa_circ_FNDC3B	FNDC3B	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001361/circ0001361 is an up-regulated FNDC3B-derived circRNA in bladder cancer. It mainly localizes in the cytoplasm and promotes bladder cancer migration, invasion and metastasis through a circ0001361/miR-491-5p/MMP9 ceRNA axis. High circ0001361 expression correlates with aggressive clinicopathological features and poor overall survival, suggesting potential prognostic and therapeutic value."	0.8769
31706100	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2020	Hsa_circ_0075341 is up-regulated and exerts oncogenic properties by sponging miR-149-5p in cervical cancer.	hsa_circ_0075341	circ_0075341	hsa_circ_MAPK9	MAPK9	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0075341 is upregulated in cervical cancer tissues and is associated with larger tumor size, advanced FIGO stage, and lymph-node metastasis. Functionally, it promotes cervical cancer cell proliferation and invasion. Mechanistically, it acts as a cytoplasmic ceRNA that sponges miR-149-5p and upregulates AURKA through the hsa_circ_0075341/miR-149-5p/AURKA axis."	0.7357
31721211	The Journal of pharmacy and pharmacology	2020	CircZNF609/miR-134-5p/BTG-2 axis regulates proliferation and migration of glioma cell.		CircZNF609	hsa_circ_ZNF609	ZNF609	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	CircZNF609 is upregulated in glioma cell lines and promotes glioma cell proliferation and migration. It functions as a ceRNA for miR-134-5p and thereby modulates BTG-2 expression.	0.5554
31726270	Cancer genetics	2020	"Circ-SLC7A5, a potential prognostic circulating biomarker for detection of ESCC."		circ_SLC7A5	hsa_circ_SLC7A5	SLC7A5	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"circ-SLC7A5 was consistently up-regulated in ESCC plasma, tissues, and cells and was proposed as a circulating biomarker. High plasma circ-SLC7A5 correlated with advanced TNM stage and poorer overall survival, and the study predicted that it may act through miRNA sponge/ceRNA-related mechanisms with possible m6A-associated translation potential."	0.7277
31726270	Cancer genetics	2020	"Circ-SLC7A5, a potential prognostic circulating biomarker for detection of ESCC."		circ-NCAM2	hsa_circ_NCAM2	NCAM2	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	dysregulated	RT-qPCR; Microarray	"circ-NCAM2 was selected from the plasma circRNA microarray screen and validated by qRT-PCR in ESCC plasma, tissues, and cell lines. Its expression pattern was inconsistent across sample types, and the study did not establish a functional mechanism or clinical prognostic value for this circRNA."	0.3588
31726270	Cancer genetics	2020	"Circ-SLC7A5, a potential prognostic circulating biomarker for detection of ESCC."		circ-C2orf29	hsa_circ_C2orf29	C2orf29	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	"circ-C2orf29 was selected from the ESCC plasma circRNA microarray screen and validated by qRT-PCR. It was down-regulated in ESCC plasma, tissues, and most ESCC cell lines compared with controls, but no mechanistic or prognostic role was established."	0.3588
31726270	Cancer genetics	2020	"Circ-SLC7A5, a potential prognostic circulating biomarker for detection of ESCC."		circ-MTCH	hsa_circ_MTCH	MTCH	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	"circ-MTCH was selected from the plasma circRNA microarray screen and validated by qRT-PCR in ESCC plasma, tissues, and cell lines. It was down-regulated in ESCC plasma, tissues, and most ESCC cell lines, but no mechanism, diagnostic performance, or prognostic association was established."	0.3588
31727503	"Pathology, research and practice"	2019	Circular RNA circ_0102049 promotes cell progression as ceRNA to target MDM2 via sponging miR-1304-5p in osteosarcoma.	hsa_circ_0102049	circ_0102049	hsa_circ_ATL1	ATL1	Osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ_0102049 is upregulated in osteosarcoma tissues and cell lines, and high expression is associated with larger tumor size, pulmonary metastasis, and poor overall survival. Functionally, circ_0102049 promotes OS cell proliferation, migration and invasion while suppressing apoptosis. Mechanistically, it acts as a cytoplasmic ceRNA that sponges miR-1304-5p to increase MDM2 expression."	0.7628
31734859	Cancer microenvironment : official journal of the International Cancer Microenvironment Society	2019	Cross-Talk Between circRNAs and mRNAs Modulates MiRNA-mediated Circuits and Affects Melanoma Plasticity.	hsa_circ_0004907	circZEB1	hsa_circ_ZEB1	ZEB1	melanoma	MONDO:0005105	melanoma	down-regulated	RT-qPCR	"This study investigated circZEB1 in human melanoma cells as part of the ZEB1-mir200 ceRNA circuit related to EMT, aggressiveness, and phenotypic switching. circZEB1 was reduced in metastatic melanoma cell lines relative to matched primary melanoma cell lines, but remained high and relatively constant during CSC-associated phenotypic switching. The authors propose that its constant expression can be explained by a limiting back-splicing factor under high ZEB1 transcription conditions."	0.4375
31735661	International immunopharmacology	2020	circAtp9b knockdown alleviates LPS-caused inflammation provided that microRNA-27a is upregulated.		circular RNA-Atp9b / circAtp9b	hsa_circ_Atp9b	Atp9b	pneumonia	MONDO:0005249	pneumonia	up-regulated	RT-qPCR	"circAtp9b is up-regulated in LPS-stimulated human MRC-5 lung fibroblasts and contributes to inflammatory injury. Knockdown of circAtp9b protects cells by restoring miR-27a, reducing apoptosis, cytokine production and ROS, and inhibiting NF-kappaB/JNK signaling, with TLR4 acting as a miR-27a downstream target."	0.5301
31736156	Journal of cellular biochemistry	2020	Circular RNA hsa_circ_0030018 acts as a sponge of miR-599 to aggravate esophageal carcinoma progression by regulating ENAH expression.	hsa_circ_0030018	circ_0030018	hsa_circ_POSTN	POSTN	Esophageal carcinoma	MONDO:0019086	carcinoma of esophagus	up-regulated	RT-qPCR	"hsa_circ_0030018 is up-regulated in esophageal carcinoma cells and promotes proliferation, migration, and EMT. Mechanistically, it is mainly cytoplasmic and acts as a miR-599 sponge to positively regulate ENAH expression, thereby aggravating EC progression. The authors propose it as a potential biomarker and therapeutic target for EC."	0.7909
31736412	"Cell cycle (Georgetown, Tex.)"	2019	Circ_0000003 promotes the proliferation and metastasis of non-small cell lung cancer cells via miR-338-3p/insulin receptor substrate 2.	hsa_circ_0000003	circ_0000003			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0000003 is up-regulated in NSCLC tissues and cell lines and is associated with adverse clinicopathological features, including lymph node metastasis and higher TNM/T stage. Functionally, circ_0000003 promotes NSCLC cell proliferation, migration, invasion, metastasis and xenograft tumor growth while suppressing apoptosis. Mechanistically, it acts as a ceRNA for miR-338-3p to increase IRS2 expression through the circ_0000003/miR-338-3p/IRS2 axis."	0.6542
31747371	Biological chemistry	2020	Circular RNA hsa_circ_0001178 facilitates the invasion and metastasis of colorectal cancer through upregulating ZEB1 via sponging multiple miRNAs.	hsa_circ_0001178				colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"hsa_circ_0001178 is upregulated in metastatic colorectal cancer and high expression is associated with aggressive clinicopathologic features and poor survival. Functionally, it promotes CRC migration, invasion, EMT, and lung/liver metastasis by sponging miR-382, miR-587, and miR-616 to increase ZEB1 expression. ZEB1 also transcriptionally activates hsa_circ_0001178, forming a positive feedback ceRNA loop that amplifies CRC metastatic dissemination."	0.7789
31749230	Molecular carcinogenesis	2020	"circMTDH.4/miR-630/AEG-1 axis participates in the regulation of proliferation, migration, invasion, chemoresistance, and radioresistance of NSCLC."		circMTDH.4 / circ-MTDH.4	hsa_circ_SNORD115-4	SNORD115-4	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circMTDH.4 is up-regulated in NSCLC tissues and cells. The study identifies a circMTDH.4/miR-630/AEG-1 ceRNA axis in which circMTDH.4 sponges miR-630 to increase AEG-1 expression, thereby contributing to proliferation-related effects and resistance to chemotherapy and radiotherapy in NSCLC cells."	0.7165
31758574	Cell biochemistry and function	2020	Circ_0001658 promotes the proliferation and metastasis of osteosarcoma cells via regulating miR-382-5p/YB-1 axis.	hsa_circ_0001658	circ_0001658			osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"Circ_0001658 is up-regulated in osteosarcoma tissues and cell lines. It promotes OS cell proliferation, migration, invasion and metastasis while suppressing apoptosis through a miR-382-5p/YB-1 regulatory axis, and its high expression is associated with early relapse in OS patients."	0.6536
31759525	Taiwanese journal of obstetrics & gynecology	2019	The expression profile of circRNA and its potential regulatory targets in the placentas of severe pre-eclampsia.	hsa_circ_0001438		hsa_circ_LARP1B	LARP1B	severe preeclampsia / SPE	MONDO:0001641	severe pre-eclampsia	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0001438 is upregulated in placental tissues from sPE patients and was validated by RT-qPCR after RNA-seq screening. The study predicts that it may participate in sPE pathogenesis through a circRNA-miRNA-mRNA ceRNA network and may serve as a diagnostic biomarker.	0.585
31759525	Taiwanese journal of obstetrics & gynecology	2019	The expression profile of circRNA and its potential regulatory targets in the placentas of severe pre-eclampsia.	hsa_circ_0001326		hsa_circ_PHLDB2	PHLDB2	severe preeclampsia / SPE	MONDO:0001641	severe pre-eclampsia	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0001326 is upregulated in placental tissues from sPE patients and was validated by RT-qPCR after RNA-seq screening. The study predicts that it may participate in sPE pathogenesis through a circRNA-miRNA-mRNA ceRNA network and may serve as a diagnostic biomarker.	0.585
31759525	Taiwanese journal of obstetrics & gynecology	2019	The expression profile of circRNA and its potential regulatory targets in the placentas of severe pre-eclampsia.		hsa_circ_32340	hsa_circ_SHANK2	SHANK2	severe preeclampsia / SPE	MONDO:0001641	severe pre-eclampsia	up-regulated	RT-qPCR; RNA-seq	hsa_circ_32340 is upregulated in placental tissues from sPE patients and was validated by RT-qPCR after RNA-seq screening. The study predicts that it may participate in sPE pathogenesis through a circRNA-miRNA-mRNA ceRNA network and may serve as a diagnostic biomarker.	0.585
31760099	Life sciences	2020	CircLMTK2 acts as a tumor suppressor in prostate cancer via regulating the expression of microRNA-183.		circLMTK2	hsa_circ_LMTK2	LMTK2	Prostate cancer / PCa	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR	"circLMTK2 is down-regulated in prostate cancer tissues and functions as a tumor suppressor. Overexpression of circLMTK2 inhibits proliferation, migration, invasion, metastasis-related behavior, PI3K/AKT signaling and Wnt/beta-catenin signaling while promoting apoptosis, largely through decreasing miR-183 expression."	0.5434
31761328	Biochemical and biophysical research communications	2020	Circular RNA circDLGAP4 exerts neuroprotective effects via modulating miR-134-5p/CREB pathway in Parkinson's disease.	hsa_circ_0060180	circDLGAP4	hsa_circ_DLGAP4	DLGAP4	Parkinson's disease / PD	MONDO:0005180	Parkinson disease	down-regulated	RT-qPCR	"circDLGAP4 is down-regulated in MPTP-induced mouse and MPP _-induced cellular PD models. It functions as a neuroprotective circRNA by sponging miR-134-5p, thereby relieving suppression of CREB signaling and influencing downstream genes including BDNF, Bcl-2 and PGC-1a. Functionally, circDLGAP4 promotes neuronal cell viability and autophagy while reducing apoptosis and mitochondrial damage in PD models."	0.5607
31761328	Biochemical and biophysical research communications	2020	Circular RNA circDLGAP4 exerts neuroprotective effects via modulating miR-134-5p/CREB pathway in Parkinson's disease.	mmu_circ_0001098	circDLGAP4	mmu_circ_DLGAP4	DLGAP4	Parkinson's disease / PD	MONDO:0005180	Parkinson disease	down-regulated	RT-qPCR	"circDLGAP4 is down-regulated in MPTP-induced mouse and MPP _-induced cellular PD models. It functions as a neuroprotective circRNA by sponging miR-134-5p, thereby relieving suppression of CREB signaling and influencing downstream genes including BDNF, Bcl-2 and PGC-1a. Functionally, circDLGAP4 promotes neuronal cell viability and autophagy while reducing apoptosis and mitochondrial damage in PD models."	0.5607
31776835	Journal of mammary gland biology and neoplasia	2019	Circ-TFCP2L1 Promotes the Proliferation and Migration of Triple Negative Breast Cancer through Sponging miR-7 by Inhibiting PAK1.		circ-TFCP2L1	hsa_circ_TFCP2L1	TFCP2L1	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; Microarray	"circ-TFCP2L1 is up-regulated in TNBC tissues and cell lines and is associated with advanced TNM stage and reduced disease-free survival. Functionally, circ-TFCP2L1 promotes TNBC cell proliferation and migration. Mechanistically, it is mainly cytoplasmic and acts as a sponge for miR-7 to regulate PAK1 in a circ-TFCP2L1/miR-7/PAK1 axis."	0.8707
31776848	Journal of thrombosis and thrombolysis	2020	Hsa_circ_0046159 is involved in the development of chronic thromboembolic pulmonary hypertension.	hsa_circ_0046159				chronic thromboembolic pulmonary hypertension / CTEPH	MONDO:0013024	chronic thromboembolic pulmonary hypertension	up-regulated	RT-qPCR; Microarray	hsa_circ_0046159 was significantly upregulated in peripheral blood from CTEPH patients. The study predicts that it may contribute to CTEPH development through a ceRNA axis involving miR-1226-3p and ATP2A2.	0.4032
31776848	Journal of thrombosis and thrombolysis	2020	Hsa_circ_0046159 is involved in the development of chronic thromboembolic pulmonary hypertension.	hsa_circ_0026480				chronic thromboembolic pulmonary hypertension / CTEPH	MONDO:0013024	chronic thromboembolic pulmonary hypertension	down-regulated	Microarray	"hsa_circ_0026480 was identified as downregulated in CTEPH by circRNA microarray and had a high degree in the miRNA-circRNA regulatory network. The proposed mechanism is a predicted hsa_circ_0026480-miR-27a-3p-ATXN1 ceRNA axis, although qRT-PCR did not significantly validate its decreased expression."	0.348
31776848	Journal of thrombosis and thrombolysis	2020	Hsa_circ_0046159 is involved in the development of chronic thromboembolic pulmonary hypertension.	hsa_circ_0076859				chronic thromboembolic pulmonary hypertension / CTEPH	MONDO:0013024	chronic thromboembolic pulmonary hypertension	down-regulated	Microarray	hsa_circ_0076859 was identified as downregulated in CTEPH-related circRNA microarray analysis and was predicted to participate in ceRNA relationships with 817 mRNAs. No qRT-PCR validation or specific miRNA/mRNA axis was reported for this circRNA.	0.348
31776848	Journal of thrombosis and thrombolysis	2020	Hsa_circ_0046159 is involved in the development of chronic thromboembolic pulmonary hypertension.	hsa_circ_0074590				chronic thromboembolic pulmonary hypertension / CTEPH	MONDO:0013024	chronic thromboembolic pulmonary hypertension	dysregulated	Microarray	"hsa_circ_0074590 was included among four circRNAs predicted to have ceRNA relationships in CTEPH, with 886 related mRNAs. The paper did not report its expression direction, qRT-PCR validation, or a specific miRNA/mRNA axis."	0.348
31778020	IUBMB life	2020	Circular RNA hsa_circ_0000654 promotes esophageal squamous cell carcinoma progression by regulating the miR-149-5p/IL-6/STAT3 pathway.	hsa_circ_0000654	circ_0000654			esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"hsa_circ_0000654/circ_0000654 is up-regulated in ESCC tissues and cell lines and is associated with higher T stage and lymph node metastasis. Functionally, it promotes proliferation, migration, invasion, tumor growth, and metastasis while inhibiting apoptosis. Mechanistically, circ_0000654 sponges miR-149-5p and indirectly activates the IL-6/STAT3 signaling pathway."	0.7597
31784675	Gene therapy	2020	Hsa_circ_0000285 functions as a competitive endogenous RNA to promote osteosarcoma progression by sponging hsa-miRNA-599.	hsa_circ_0000285	circ-0000285	hsa_circ_HIPK3	HIPK3	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"Hsa_circ_0000285/circ-0000285 is up-regulated in osteosarcoma cell lines and promotes osteosarcoma proliferation, migration, tumor growth, and metastatic nodule formation. Mechanistically, it is mainly cytoplasmic and functions as a ceRNA that sponges miRNA-599, thereby positively regulating TGFB2 expression through the circ-0000285/miRNA-599/TGFB2 axis."	0.8207
31786325	The international journal of biochemistry & cell biology	2020	Lung myofibroblast transition and fibrosis is regulated by circ0044226.		circ0044226 / circRNA_102100			Idiopathic pulmonary fibrosis / IPF	MONDO:0800504	idiopathic pulmonary fibrosis	up-regulated	RT-qPCR	"circ0044226 is upregulated in bleomycin-induced pulmonary fibrosis mice and TGF-beta1-induced WI-38 myofibroblast differentiation models. It mainly localizes to the cytoplasm and promotes fibroblast-to-myofibroblast transition, fibroblast proliferation, and pulmonary fibrosis by sponging miR-7 and increasing sp1 expression. Knockdown of circ0044226 attenuates fibrosis-related changes in vitro and in vivo, suggesting therapeutic potential for pulmonary fibrosis."	0.6006
31793082	"BioFactors (Oxford, England)"	2020	Circular RNA ANKRD36 attends to lipopolysaccharide-aroused MRC-5 cell injury via regulating microRNA-31-3p.		circRNA ankyrin repeat domain 36 / circANKRD36	hsa_circ_ANKRD36		pneumonia	MONDO:0005249	pneumonia	up-regulated	RT-qPCR	"In an LPS-irritated MRC-5 in vitro pneumonia-related injury model, circANKRD36 was up-regulated and contributed to cell injury. Silencing circANKRD36 increased miR-31-3p, reduced MyD88/NF-kappaB pathway activation, and alleviated apoptosis, ROS generation, and inflammatory cytokine production. The study suggests circANKRD36 as a potential therapeutic target for pneumonia-related inflammatory lung cell injury."	0.6435
31800303	Biochemistry and cell biology = Biochimie et biologie cellulaire	2020	Circ_KATNAL1 regulates prostate cancer cell growth and invasiveness through the miR-145-3p/WISP1 pathway.	hsa_circ_0008068	circ_KATNAL1	hsa_circ_KATNAL1	KATNAL1	Prostate cancer / PCa	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR	"circ_KATNAL1 (hsa_circ_0008068), derived from KATNAL1, is down-regulated in prostate cancer cells and mainly localized in the cytoplasm. It directly binds miR-145-3p and functions through the miR-145-3p/WISP1 pathway to suppress proliferation, invasion and migration while promoting apoptosis. The study suggests circ_KATNAL1 acts as a tumor suppressor and may be a potential diagnostic or therapeutic target in PCa."	0.6874
31804889	DNA and cell biology	2019	"circRNA/lncRNA-miRNA-mRNA Network in Oxidized, Low-Density, Lipoprotein-Induced Foam Cells."	hsa_circ_0028198				atherosclerosis	MONDO:0005311	atherosclerosis	up-regulated	Microarray	"hsa_circ_0028198 was identified as an upregulated circRNA in ox-LDL-induced foam cells. The study predicts that it may act through a ceRNA axis with miR-543 to regulate ASPH and PDE3B, suggesting potential relevance to atherosclerosis mechanisms and therapeutic targeting."	0.1768
31804889	DNA and cell biology	2019	"circRNA/lncRNA-miRNA-mRNA Network in Oxidized, Low-Density, Lipoprotein-Induced Foam Cells."	hsa_circ_0092317				atherosclerosis	MONDO:0005311	atherosclerosis	up-regulated	Microarray	"hsa_circ_0092317 was identified as an upregulated circRNA in ox-LDL-induced foam cells. It was incorporated into predicted ceRNA axes involving miR-543-ASPH, miR-543-PDE3B, and miR-326-PDE3B, suggesting a possible role in atherosclerosis-related regulatory networks."	0.1768
31804889	DNA and cell biology	2019	"circRNA/lncRNA-miRNA-mRNA Network in Oxidized, Low-Density, Lipoprotein-Induced Foam Cells."	hsa_circ_0003546		hsa_circ_DENND5A	DENN-D5A	atherosclerosis	MONDO:0005311	atherosclerosis	up-regulated	Microarray	"hsa_circ_0003546 was identified as an upregulated circRNA in ox-LDL-induced foam cells. The study predicts that it may interact with miR-326 in a ceRNA axis regulating PDE3B, potentially linking it to atherosclerosis-associated apoptosis and angiogenesis regulation."	0.1768
31809842	Gene	2020	Overexpression of circular RNA hsa_circ_0001038 promotes cervical cancer cell progression by acting as a ceRNA for miR-337-3p to regulate cyclin-M3 and metastasis-associated in colon cancer 1 expression.	hsa_circ_0001038		hsa_circ_POLR1A	POLR1A	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"hsa_circ_0001038 is up-regulated in cervical cancer tissues and cell lines and high expression predicts poorer overall survival. Functionally, it promotes cervical cancer cell growth, migration, and invasion while suppressing apoptosis. Mechanistically, it acts as a ceRNA for miR-337-3p to increase CNNM3 and MACC1 expression."	0.7113
31810373	"Artificial cells, nanomedicine, and biotechnology"	2019	Circular RNA ADAM9 facilitates the malignant behaviours of pancreatic cancer by sponging miR-217 and upregulating PRSS3 expression.		circ-ADAM9	hsa_circ_ADAM9	ADAM9	pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"circ-ADAM9 is up-regulated in pancreatic cancer tissues and cell lines and is associated with advanced TNM stage, lymph node metastasis, and poor survival. Functionally, it promotes proliferation, migration, invasion, and xenograft tumour growth by sponging miR-217, increasing PRSS3 expression, and activating ERK/VEGF signalling."	0.7537
31810586	"Pathology, research and practice"	2020	Clinical significance of hsa_circ_0000419 in gastric cancer screening and prognosis estimation.	hsa_circ_0000419		hsa_circ_RAB3IP		gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0000419 is significantly down-regulated in gastric cancer cell lines, tumor tissues, and plasma. Its lower expression is associated with worse survival and advanced clinicopathological features, supporting its value as a GC screening and prognostic biomarker. Bioinformatics analysis suggests that it may participate in gastric tumorigenesis and progression through hsa-miR-141-5p and hsa-miR-589-3p-related downstream regulatory networks."	0.636
31811601	Cell biochemistry and biophysics	2020	CircMYC Regulates Glycolysis and Cell Proliferation in Melanoma.	hsa_circ_0085533	circMYC / circ_0085533	hsa_circ_MYC	c-Myc	melanoma	MONDO:0005105	melanoma	up-regulated	RT-qPCR	"In melanoma, human circMYC (hsa_circ_0085533) is up-regulated in tumor tissues and promotes melanoma cell proliferation, viability, glycolysis, lactate production, and LDHA expression. Mechanistically, circMYC sponges miR-1236 to relieve repression of LDHA, while c-Myc and SRSF1 positively regulate circMYC production. The study suggests circMYC may serve as a diagnostic biomarker for malignant melanoma."	0.8271
31811909	Cancer letters	2020	Circular RNA circ-RanGAP1 regulates VEGFA expression by targeting miR-877-3p to facilitate gastric cancer invasion and metastasis.	hsa_circ_0063526	circ-RanGAP1 / circRanGAP1	hsa_circ_RanGAP1	RanGAP1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circ-RanGAP1/hsa_circ_0063526 is upregulated in gastric cancer tissues and plasma exosomes and high expression predicts poor overall survival. Functionally, it promotes GC proliferation, invasion, migration, angiogenesis, tumor growth and metastasis. Mechanistically, circ-RanGAP1 acts as a ceRNA for miR-877-3p to increase VEGFA expression, and plasma exosomal circ-RanGAP1 may contribute to GC progression and biomarker utility."	0.874
31823158	Investigational new drugs	2020	"Microarray expression profiles and bioinformatics analysis of mRNAs, lncRNAs, and circRNAs in the secondary temozolomide-resistant glioblastoma."	hsa_circ_0043949	circ_0043949			glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0043949 was up-regulated in secondary temozolomide-resistant glioblastoma and validated by qRT-PCR. The study links its high expression to TMZ chemoresistance and predicts that it may act through circRNA-miRNA interactions involving several candidate miRNAs, including hsa-miR-140-3p."	0.4032
31823158	Investigational new drugs	2020	"Microarray expression profiles and bioinformatics analysis of mRNAs, lncRNAs, and circRNAs in the secondary temozolomide-resistant glioblastoma."		hsa_circ_002775 / circ_002775			glioblastoma / GBM	MONDO:0018177	glioblastoma	dysregulated	Microarray	"hsa_circ_002775 was one of the differentially expressed circRNAs analyzed in STRG. The study predicted that it may act as a ceRNA for miR-320a, miR616-3p and miR-185-3p, but no RT-qPCR-confirmed disease association was reported for this circRNA."	0.348
31823158	Investigational new drugs	2020	"Microarray expression profiles and bioinformatics analysis of mRNAs, lncRNAs, and circRNAs in the secondary temozolomide-resistant glioblastoma."	hsa_circ_0005405				glioblastoma / GBM	MONDO:0018177	glioblastoma	dysregulated	Microarray	"hsa_circ_0005405 was included among the top differential circRNAs used to construct the STRG circRNA-miRNA network. It was predicted to be co-related with miR-608, but its expression change was not individually validated by qRT-PCR in the reported text."	0.348
31823158	Investigational new drugs	2020	"Microarray expression profiles and bioinformatics analysis of mRNAs, lncRNAs, and circRNAs in the secondary temozolomide-resistant glioblastoma."	hsa_circ_0051144				glioblastoma / GBM	MONDO:0018177	glioblastoma	dysregulated	Microarray	"hsa_circ_0051144 was included among the top differential circRNAs used to construct the STRG circRNA-miRNA network. It was predicted to be co-related with miR-608, but its expression change was not individually validated by qRT-PCR in the reported text."	0.348
31823158	Investigational new drugs	2020	"Microarray expression profiles and bioinformatics analysis of mRNAs, lncRNAs, and circRNAs in the secondary temozolomide-resistant glioblastoma."	hsa_circ_0023017				glioblastoma / GBM	MONDO:0018177	glioblastoma	dysregulated	Microarray	"hsa_circ_0023017 was included among the top differential circRNAs used to construct the STRG circRNA-miRNA network. It was predicted to be co-related with miR-608, but its expression change was not individually validated by qRT-PCR in the reported text."	0.348
31825292	Journal of toxicology and environmental health. Part A	2019	Circular RNA expression profiles following MC-LR treatment in human normal liver cell line (HL7702) cells using high-throughput sequencing analysis.	hsa_circ_0000657				hepatotoxicity	MONDO:0005359	drug-induced liver injury	down-regulated	RT-qPCR; RNA-seq	"hsa_circRNA_0000657 was down-regulated in MC-LR-treated human normal liver HL7702 cells. Its differential expression was supported by high-throughput sequencing and qRT-PCR, suggesting a potential association with MC-LR-induced hepatotoxicity."	0.4276
31825292	Journal of toxicology and environmental health. Part A	2019	Circular RNA expression profiles following MC-LR treatment in human normal liver cell line (HL7702) cells using high-throughput sequencing analysis.	hsa_circ_0000659				hepatotoxicity	MONDO:0005359	drug-induced liver injury	down-regulated	RT-qPCR; RNA-seq	"hsa_circRNA_0000659 was down-regulated in MC-LR-treated human normal liver HL7702 cells. Its differential expression was supported by high-throughput sequencing and qRT-PCR, suggesting a potential association with MC-LR-induced hepatotoxicity."	0.4276
31825292	Journal of toxicology and environmental health. Part A	2019	Circular RNA expression profiles following MC-LR treatment in human normal liver cell line (HL7702) cells using high-throughput sequencing analysis.	hsa_circ_0003247				hepatotoxicity	MONDO:0005359	drug-induced liver injury	up-regulated	RT-qPCR; RNA-seq	"hsa_circRNA_0003247 was up-regulated in MC-LR-treated human normal liver HL7702 cells. Its differential expression was supported by high-throughput sequencing and qRT-PCR, suggesting a potential association with MC-LR-induced hepatotoxicity."	0.4276
31825292	Journal of toxicology and environmental health. Part A	2019	Circular RNA expression profiles following MC-LR treatment in human normal liver cell line (HL7702) cells using high-throughput sequencing analysis.	hsa_circ_0001535				hepatotoxicity	MONDO:0005359	drug-induced liver injury	up-regulated	RT-qPCR; RNA-seq	"hsa_circRNA_0001535 was up-regulated in MC-LR-treated human normal liver HL7702 cells. Its differential expression was supported by high-throughput sequencing and qRT-PCR, suggesting a potential association with MC-LR-induced hepatotoxicity."	0.4276
31837293	Experimental cell research	2020	Knock-down of circular RNA H19 induces human adipose-derived stem cells adipogenic differentiation via a mechanism involving the polypyrimidine tract-binding protein 1.	hsa_circ_0095570	circular RNA H19	hsa_circ_H19	H19	Metabolic syndrome / MetS	MONDO:0011565	metabolic syndrome X	up-regulated	RT-qPCR	"This study reports that circulating hsa_circH19 is up-regulated in serum from MetS patients and has diagnostic biomarker potential. Functionally, hsa_circH19 knockdown promotes adipogenic differentiation and lipid accumulation in human ADSCs by relieving PTBP1-mediated SREBP1 cleavage and nuclear translocation regulation."	0.841
31838741	"Hepatology (Baltimore, Md.)"	2020	Circular RNA Sequencing Identifies CircASAP1 as a Key Regulator in Hepatocellular Carcinoma Metastasis.	hsa_circ_0085616	circASAP1	hsa_circ_ASAP1	ASAP1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circASAP1 is an up-regulated human circRNA in metastatic/recurrent HCC and is associated with pulmonary metastasis and poor prognosis. It promotes HCC proliferation, invasion, tumor growth, and lung metastasis by sponging miR-326 and miR-532-5p, thereby increasing MAPK1 and CSF-1 signaling and enhancing tumor-associated macrophage infiltration."	0.8913
31843366	"Heart, lung & circulation"	2020	Identification of Long Non-Coding RNA and Circular RNA Expression Profiles in Atrial Fibrillation.		chr13_41887361_41865736_-21625			atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	up-regulated	RT-qPCR; RNA-seq	"chr13_41887361_41865736_-21625 was identified by RNA-seq and validated by qRT-PCR as significantly up-regulated in atrial tissues from AF patients. The study did not perform functional experiments for this circRNA, but incorporated circRNAs into predicted circRNA-miRNA-mRNA ceRNA network analyses to provide clues for AF pathology."	0.4032
31843366	"Heart, lung & circulation"	2020	Identification of Long Non-Coding RNA and Circular RNA Expression Profiles in Atrial Fibrillation.		chr13_100368574_100301460_-67114			atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	up-regulated	RT-qPCR; RNA-seq	"chr13_100368574_100301460_-67114 was identified by RNA-seq and validated by qRT-PCR as significantly up-regulated in atrial tissues from AF patients. The study did not experimentally define its function, but analyzed circRNAs within predicted circRNA-miRNA-mRNA ceRNA networks as potential contributors to AF pathology."	0.4032
31846689	Cancer letters	2020	Androgen receptor reverses the oncometabolite R-2-hydroxyglutarate-induced prostate cancer cell invasion via suppressing the circRNA-51217/miRNA-646/TGFbeta1/p-Smad2/3 signaling.		circRNA-51217	hsa_circ_TGFbeta1	TGFbeta1	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circRNA-51217 is induced by R-2HG/IDH1 R132H-related conditions in prostate cancer cells with negative or low AR expression. It promotes PCa cell invasion by sponging miRNA-646, increasing TGFbeta1 expression, and activating TGFbeta1/p-Smad2/3 signaling; AR counteracts this pathway partly through TGFbeta1 transcriptional repression and ADAR2-mediated suppression of circRNA generation."	0.6596
31846689	Cancer letters	2020	Androgen receptor reverses the oncometabolite R-2-hydroxyglutarate-induced prostate cancer cell invasion via suppressing the circRNA-51217/miRNA-646/TGFbeta1/p-Smad2/3 signaling.		circRNA-51213	hsa_circ_TGFbeta1	TGFbeta1	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circRNA-51213 was identified as a TGFbeta1-related circRNA whose expression is significantly induced by R-2HG in PC3 prostate cancer cells. AR overexpression suppresses circRNA-51213 and reverses its R-2HG-induced upregulation, but the article did not pursue circRNA-51213 functional or mechanistic validation beyond expression analysis."	0.2586
31859543	DNA and cell biology	2020	circCCT3 Modulates Vascular Endothelial Growth Factor A and Wnt Signaling to Enhance Colorectal Cancer Metastasis Through Sponging miR-613.	hsa_circ_0004680	CircCCT3	hsa_circ_CCT3	CCT3	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RNA-seq	"circCCT3 is up-regulated in human CRC tumors and is associated with advanced stage and poorer disease-free survival. Functionally, circCCT3 promotes CRC cell invasion/metastasis and suppresses apoptosis. Mechanistically, it sponges miR-613 to regulate WNT3, VEGFA and Wnt signaling."	0.7718
31863774	Life sciences	2020	CircACAP2 promotes breast cancer proliferation and metastasis by targeting miR-29a/b-3p-COL5A1 axis.		circRNA ACAP2 / circACAP2	hsa_circ_ACAP2	ACAP2	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circACAP2 is up-regulated in breast cancer tissues and cell lines. It promotes breast cancer proliferation, migration, invasion, metastasis and xenograft tumor growth while suppressing apoptosis, mainly by sponging miR-29a-3p and miR-29b-3p to regulate COL5A1. The study suggests circACAP2 may serve as a potential diagnostic and therapeutic biomarker for breast cancer."	0.7525
31864925	"Environmental pollution (Barking, Essex : 1987)"	2020	CircRNA104250 and lncRNAuc001.dgp.1 promote the PM2.5-induced inflammatory response by co-targeting miR-3607-5p in BEAS-2B cells.	hsa_circ_0004587	circRNA104250	hsa_circ_TMEM181	TMEM181	PM 2.5-induced lung inflammation	MONDO:0005087	respiratory system disorder	up-regulated	RT-qPCR; Microarray	"circRNA104250 (hsa_circ_0004587), derived from TMEM181, is significantly up-regulated in PM 2.5-treated BEAS-2B human bronchial epithelial cells. It promotes the PM 2.5-induced inflammatory response by co-targeting miR-3607-5p with lncRNAuc001.dgp.1, positively regulating IL1R1, activating the NF-kappaB axis, and inducing IL-6 and IL-8 release."	0.7924
31865777	"Artificial cells, nanomedicine, and biotechnology"	2020	Silencing hsa_circ_PVT1 (circPVT1) suppresses the growth and metastasis of glioblastoma multiforme cells by up-regulation of miR-199a-5p.		circPVT1	hsa_circ_PVT1	PVT1	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR	"hsa_circ_PVT1/circPVT1 is up-regulated in GBM tissues. In GBM cell lines, circPVT1 knockdown suppresses viability, migration, EGF-induced EMT and PI3K/AKT/YAP1-related signaling while promoting apoptosis, largely through up-regulation of miR-199a-5p. The study suggests circPVT1 as a potential therapeutic target for GBM."	0.5414
31878833	"Cell cycle (Georgetown, Tex.)"	2020	Circular RNA circDENND2A protects H9c2 cells from oxygen glucose deprivation-induced apoptosis through sponging microRNA-34a.		circDENND2A		DENND2A	myocardial ischemia	MONDO:0024644	myocardial ischemia	up-regulated	RT-qPCR	"This study found that circDENND2A is up-regulated in AMI/MI patient blood and in OGD-treated H9c2 cells. Functionally, circDENND2A protects cardiomyocyte-like H9c2 cells from OGD-induced injury by promoting viability and migration while suppressing apoptosis. Mechanistically, circDENND2A sponges miR-34a and is linked to activation of beta-catenin and Ras/Raf/MEK/ERK signaling."	0.6521
31878833	"Cell cycle (Georgetown, Tex.)"	2020	Circular RNA circDENND2A protects H9c2 cells from oxygen glucose deprivation-induced apoptosis through sponging microRNA-34a.		circDENND2A		DENND2A	myocardial ischemia	MONDO:0024644	myocardial ischemia	up-regulated	RT-qPCR	"This study found that circDENND2A is up-regulated in AMI/MI patient blood and in OGD-treated H9c2 cells. Functionally, circDENND2A protects cardiomyocyte-like H9c2 cells from OGD-induced injury by promoting viability and migration while suppressing apoptosis. Mechanistically, circDENND2A sponges miR-34a and is linked to activation of beta-catenin and Ras/Raf/MEK/ERK signaling."	0.6521
31881486	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2020	Circular RNA CDR1-AS contributes to pemetrexed and cisplatin chemoresistance through EGFR/PI3K signaling pathway in lung adenocarcinoma.		CDR1-AS / CiRS-7	hsa_circ_CDR1-AS	CDR1 Antisense RNA (CDR1-AS) gene	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"CDR1-AS is up-regulated in LUAD tissues and cell lines, especially in pemetrexed/cisplatin-insensitive LUAD samples and the resistant A549/CR cell line. High CDR1-AS expression predicts poorer overall survival and functions as an independent prognostic biomarker. Functionally, silencing CDR1-AS re-sensitizes resistant LUAD cells to pemetrexed and cisplatin, while EGFR up-regulation largely reverses this effect, indicating that CDR1-AS promotes chemoresistance through the EGFR/PI3K pathway."	0.7682
31882179	"Pathology, research and practice"	2020	Screening and identification of epithelial-to-mesenchymal transition-related circRNA and miRNA in prostate cancer.	hsa_circ_0001085				prostate cancer / PCa	MONDO:0008315	prostate cancer	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0001085 was differentially expressed in an IFN-gamma-induced prostate cancer EMT model and validated by qPCR. The study predicted that it may regulate PI3K-Akt, TGF-beta, and MAPK signaling through hsa-miR-196b-5p and hsa-miR-451a, suggesting a role in EMT-related prostate cancer cell regulation."	0.4943
31882179	"Pathology, research and practice"	2020	Screening and identification of epithelial-to-mesenchymal transition-related circRNA and miRNA in prostate cancer.	hsa_circ_0001165				prostate cancer / PCa	MONDO:0008315	prostate cancer	dysregulated	RT-qPCR; RNA-seq	hsa_circ_0001165 was differentially expressed in the IFN-gamma-induced prostate cancer EMT model and validated by qPCR. The study predicts that it may promote EMT by regulating TNF through hsa-miR-187-3p in a circRNA-miRNA-mRNA network.	0.4943
31882179	"Pathology, research and practice"	2020	Screening and identification of epithelial-to-mesenchymal transition-related circRNA and miRNA in prostate cancer.	hsa_circ_0004916				prostate cancer / PCa	MONDO:0008315	prostate cancer	dysregulated	RT-qPCR; RNA-seq	hsa_circ_0004916 was identified as a differentially expressed circRNA in the IFN-gamma-induced prostate cancer EMT model and its expression was validated by qPCR. The paper did not define a specific downstream regulatory axis or functional mechanism for this circRNA.	0.4566
31889339	"BioFactors (Oxford, England)"	2020	Knockdown of circular RNA circZNF652 remits LPS-induced inflammatory damage by regulating miR-181a.		circZNF652	hsa_circ_ZNF652	ZNF652	pneumonia	MONDO:0005249	pneumonia	up-regulated	RT-qPCR	"circZNF652 was up-regulated in the LPS-induced WI-38 cell inflammatory injury model of infantile pneumonia. Silencing circZNF652 alleviated inflammatory injury by increasing cell viability and reducing apoptosis, Cox-2, and inflammatory cytokines. Mechanistically, circZNF652 negatively regulated miR-181a and promoted activation of the NF-kappaB and JNK/p38 pathways."	0.4611
31894486	Digestive diseases and sciences	2020	MetaDE-Based Analysis of circRNA Expression Profiles Involved in Gastric Cancer.	hsa_circ_0005927				gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0005927 was identified as a down-regulated circRNA in gastric cancer by integrated microarray MetaDE analysis and was validated by qRT-PCR in clinical tissues. The study proposes that it may act through a circRNA-miRNA-mRNA ceRNA network, potentially binding multiple miRNAs and regulating downstream targets such as TMEFF2, and it may serve as a biomarker for GC screening."	0.4032
31894486	Digestive diseases and sciences	2020	MetaDE-Based Analysis of circRNA Expression Profiles Involved in Gastric Cancer.	hsa_circ_0067934				gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0067934 was identified as an up-regulated circRNA in gastric cancer by integrated microarray MetaDE analysis and was validated by qRT-PCR in clinical tissues. The study proposes a predicted ceRNA network involving hsa_circ_0067934, hsa-miR-1324, and PMP22 that may be involved in GC progression, supporting its potential as a GC screening biomarker and therapeutic target clue."	0.4032
31897898	Digestive diseases and sciences	2020	Circular RNA_LARP4 Sponges miR-1323 and Hampers Progression of Esophageal Squamous Cell Carcinoma Through Modulating PTEN/PI3K/AKT Pathway.		circular RNA_LARP4 / circLARP4	hsa_circ_LARP4	LARP4	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	RT-qPCR	"circLARP4 is down-regulated in ESCC cell lines and acts as a tumor-suppressive circRNA. It inhibits proliferation, migration, EMT and PI3K/AKT signaling while promoting apoptosis, primarily by sponging miR-1323 and relieving repression of PTEN."	0.7922
31898357	Journal of cellular biochemistry	2020	A novel circular RNA circFN1 enhances cisplatin resistance in gastric cancer via sponging miR-182-5p.	hsa_circ_0058147	circFN1	hsa_circ_FN1	FN1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"circFN1 is up-regulated in cisplatin-resistant gastric cancer tissues and cell lines. It promotes CDDP resistance by acting as a ceRNA sponge for miR-182-5p, reducing apoptosis through the caspase-3 signaling pathway and enhancing cell viability and tumor growth under cisplatin treatment. Clinically, higher circFN1 expression is associated with CDDP resistance and more aggressive clinicopathological features."	0.8206
31903637	Cell biology international	2020	Extracellular vesicle-derived circ_SLC19A1 promotes prostate cancer cell growth and invasion through the miR-497/septin 2 pathway.	hsa_circ_0062019	circ_SLC19A1	hsa_circ_SLC19A1	SLC19A1	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circ_SLC19A1 is up-regulated in prostate cancer cells and their extracellular vesicles. EV-derived circ_SLC19A1 promotes PCa cell proliferation and invasion and suppresses cell death by sponging miR-497, increasing SEPT2 expression, and activating ERK1/2 signaling. The study suggests that EV-derived circ_SLC19A1 may be a therapeutic target for PCa prevention and treatment."	0.6853
31904147	Journal of cellular biochemistry	2020	Circular RNA circ-EGLN3 promotes renal cell carcinoma proliferation and aggressiveness via miR-1299-mediated IRF7 activation.	hsa_circ_0031594	circ-EGLN3	hsa_circ_EGLN3	EGLN3	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR	"circ-EGLN3 is up-regulated in RCC tissues and cell lines and high expression predicts poor overall survival. Functionally, circ-EGLN3 promotes RCC cell proliferation, migration, invasion and aggressiveness while inhibiting apoptosis. Mechanistically, cytoplasmic circ-EGLN3 acts as a ceRNA that sponges miR-1299 to increase IRF7 expression."	0.7628
31904383	Experimental cell research	2020	Expression profile and bioinformatics analyses of circular RNAs in keloid and normal dermal fibroblasts.	hsa_circ_0008259				keloid	MONDO:0005348	keloid	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0008259 was down-regulated in keloid dermal fibroblasts and validated by qRT-PCR. Functional overexpression experiments showed that it inhibited type I/III collagen-related COL1A1 and COL3A1 expression, suggesting a suppressive role in keloid-associated fibrotic collagen deposition. The study also proposed a predicted hsa_circ_0008259/miR-21-5p-related ceRNA mechanism."	0.7062
31904383	Experimental cell research	2020	Expression profile and bioinformatics analyses of circular RNAs in keloid and normal dermal fibroblasts.	hsa_circ_0005480				keloid	MONDO:0005348	keloid	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005480 was identified by high-throughput sequencing and validated by qRT-PCR as significantly down-regulated in keloid dermal fibroblasts. The study included it in a predicted circRNA-miRNA-mRNA ceRNA network, suggesting a possible role in keloid pathogenesis, but no direct functional assay or specific validated target was reported."	0.5994
31904383	Experimental cell research	2020	Expression profile and bioinformatics analyses of circular RNAs in keloid and normal dermal fibroblasts.	hsa_circ_0002198				keloid	MONDO:0005348	keloid	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0002198 was identified by high-throughput sequencing and validated by qRT-PCR as significantly up-regulated in keloid dermal fibroblasts. The study included it in a predicted circRNA-miRNA-mRNA ceRNA network and proposed a possible hsa_circ_0002198/miR-31-5p axis in keloid development, but did not experimentally validate its direct function."	0.5994
31916848	Cancer biotherapy & radiopharmaceuticals	2020	Circ_0014130 Participates in the Proliferation and Apoptosis of Nonsmall Cell Lung Cancer Cells via the miR-142-5p/IGF-1 Axis.	hsa_circ_0014130	circ_0014130			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0014130 is up-regulated in NSCLC tissues and cells. Functionally, circ_0014130 promotes NSCLC cell proliferation and suppresses apoptosis, while silencing circ_0014130 reverses these phenotypes. Mechanistically, circ_0014130 acts through the miR-142-5p/IGF-1 axis, with circ_0014130 knockdown increasing miR-142-5p and reducing IGF-1 expression."	0.6996
31919040	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2020	A novel circular RNA (hsa_circ_0000370) increases cell viability and inhibits apoptosis of FLT3-ITD-positive acute myeloid leukemia cells by regulating miR-1299 and S100A7A.	hsa_circ_0000370	circ_0000370	hsa_circ_FLI-1	FLI-1	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000370/circ_0000370 is up-regulated in FLT3-ITD-positive AML and functions as an oncogenic circRNA in vitro. It promotes AML cell viability, colony formation and S-phase progression while suppressing apoptosis, and mechanistically acts through a circ_0000370/miR-1299/S100A7A ceRNA axis. The study suggests circ_0000370 may serve as a potential diagnostic/prognostic biomarker and therapeutic target for FLT3-ITD-positive AML."	0.7968
31920098	Epigenomics	2020	Identification of circRNA-miRNA networks for exploring an underlying prognosis strategy for breast cancer.	hsa_circ_0088088	circ-0088088	hsa_circ_HSDL2	HSDL2	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq; Microarray	"hsa-circRNA-0088088 is up-regulated in breast cancer serum exosomes and tissues. The study proposes that it may act as an exosomal ceRNA/miRNA sponge, especially through the hsa-circRNA-0088088/let-7a-2-3p interaction, and may have biomarker value for BCa prediction."	0.695
31920098	Epigenomics	2020	Identification of circRNA-miRNA networks for exploring an underlying prognosis strategy for breast cancer.	hsa_circ_0005795	circ-0005795	hsa_circ_LPXN	LPXN	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; RNA-seq; Microarray	"hsa-circRNA-0005795 is down-regulated in breast cancer serum exosomes and tissues. The study proposes that it may act as an exosomal ceRNA/miRNA sponge, especially through hsa-miR-1304-3p and hsa-miR-3154 interactions, and may have biomarker value for BCa prediction."	0.695
31920098	Epigenomics	2020	Identification of circRNA-miRNA networks for exploring an underlying prognosis strategy for breast cancer.	hsa_circ_0000751	circ-0000751			breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq; Microarray	"hsa-circRNA-00000751 was identified as differentially expressed in both serum exosome RNA-seq and breast tissue microarray datasets, and RT-qPCR showed it was up-regulated in serum exosomes from BCa patients. Unlike hsa-circRNA-0088088 and hsa-circRNA-0005795, it was not further characterized mechanistically in this study."	0.5351
31920104	Epigenomics	2020	Circular RNA circVAPA regulates breast cancer cell migration and invasion via sponging miR-130a-5p.	hsa_circ_0006990	circVAPA	hsa_circ_VAPA	VAPA	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; RNA-seq	"circVAPA (hsa circ 0006990) is an up-regulated VAPA-derived circular RNA in breast cancer tissues, lymph node positive tissues, and aggressive MDA-MB-231 cells. It promotes breast cancer cell proliferation, migration and invasion in vitro, primarily through cytoplasmic miR-130a-5p sponging rather than regulation of its parental gene VAPA. The study suggests circVAPA may be associated with metastatic behavior and may have prognostic biomarker potential in breast cancer."	0.8035
31923418	Life sciences	2020	Circ_0009910 promotes imatinib resistance through ULK1-induced autophagy by sponging miR-34a-5p in chronic myeloid leukemia.	hsa_circ_0009910	circ_0009910	hsa_circ_MFN2	MFN2	chronic myeloid leukemia / CML	MONDO:0011996	"chronic myelogenous leukemia, BCR-ABL1 positive"	up-regulated	RT-qPCR	"circ_0009910 is up-regulated in serum from imatinib-resistant CML patients and in K562/R cells. It promotes imatinib resistance by sponging miR-34a-5p, increasing ULK1 expression and ULK1-induced autophagy, while reducing apoptosis. Clinically, high circ_0009910 expression is associated with diagnostic value for resistance and poorer overall survival."	0.8569
31932481	Molecular and cellular biology	2020	Interaction between HuR and circPABPN1 Modulates Autophagy in the Intestinal Epithelium by Altering ATG16L1 Translation.		circPABPN1	hsa_circ_PABPN1	PABPN1	inflammatory bowel disease / IBD	MONDO:0005265	inflammatory bowel disease	up-regulated	ISH	"circPABPN1 is up-regulated in intestinal mucosal tissues from UC patients. Mechanistically, circPABPN1 binds/sequesters HuR, prevents HuR association with Atg16l1 mRNA, and reduces ATG16L1 translation, thereby antagonizing HuR-regulated autophagy in intestinal epithelial cells."	0.6875
31932969	Medical molecular morphology	2020	The expression of MYC is strongly dependent on the circular PVT1 expression in pure Gleason pattern 4 of prostatic cancer.		Circular PVT1 / circPVT1	hsa_circ_PVT1	PVT1	prostate cancer / PCa	MONDO:0008315	prostate cancer	unknown	RT-qPCR	"This study investigated circPVT1 in prostate cancer, especially pure Gleason pattern 4, and found that circPVT1 suppression in DU145 prostate cancer cells reduced MYC protein expression. The authors conclude that circular PVT1 may preferentially contribute to MYC protein stabilization in GP4 prostate cancer, suggesting a distinct biological feature of this Gleason pattern."	0.5736
31935513	Gene	2020	Maternal obesity alters circRNA expression and the potential role of mmu_circRNA_0000660 via sponging miR_693 in offspring liver at weaning age.	mmu_circ_0000660	mmu_circRNA_0000660 / circRNA_0000660	mmu_circ_Dmgdh	Dmgdh	maternal obesity	MONDO:0011122	obesity disorder	down-regulated	RT-qPCR; RNA-seq	"This study identified circRNA_0000660 as a down-regulated hepatic circRNA in offspring of obese dams and in PA-induced AML12 cells. Functionally, loss of circRNA_0000660 aggravated lipid accumulation and reduced Igfbp1 expression. Mechanistically, circRNA_0000660 acts through a ceRNA axis by sponging miR_693 to regulate Igfbp1 in hepatic lipid metabolism."	0.7268
31941603	Biochemical and biophysical research communications	2020	"Circ_101064 regulates the proliferation, invasion and migration of glioma cells through miR-154-5p/ PIWIL1 axis."		Circ_101064			glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"Circ_101064 is up-regulated in human glioma tissues and cell lines and is associated with larger tumor diameter and advanced tumor grade. Functional knockdown experiments show that Circ_101064 promotes glioma cell proliferation, migration and invasion. Mechanistically, the study proposes a Circ_101064/miR-154e5p/PIWIL1 regulatory axis as a potential therapeutic target in glioma."	0.6479
31943342	Journal of cellular biochemistry	2020	miR-449c-5p availability is antagonized by circ-NOTCH1 for MYC-induced NOTCH1 upregulation as well as tumor metastasis and stemness in gastric cancer.		Circ-NOTCH1 / circNOTCH1	hsa_circ_NOTCH1	NOTCH1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"Circ-NOTCH1 is an up-regulated NOTCH1-derived circRNA in gastric cancer and high expression is associated with unfavorable prognosis. It promotes GC growth, migration, invasion, metastasis and stemness by sponging miR-449c-5p to regulate MYC and NOTCH1, forming a circ-NOTCH1/miR-449c-5p/MYC/NOTCH1 regulatory axis."	0.8816
31945158	Blood advances	2020	Clinical and functional significance of circular RNAs in cytogenetically normal AML.		circCFLAR	hsa_circ_CFLAR	CFLAR	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	unknown	RT-qPCR; RNA-seq	"circCFLAR is a prognostic circRNA in younger adult CN-AML. High circCFLAR expression is associated with better clinical outcome and immune-related pathway activation, but no miRNA-sponging mechanism was identified."	0.7151
31945158	Blood advances	2020	Clinical and functional significance of circular RNAs in cytogenetically normal AML.		circKLHL8	hsa_circ_KLHL8	KLHL8	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	unknown	RT-qPCR; RNA-seq	"circKLHL8 is a validated prognostic circRNA in CN-AML. High expression predicts longer DFS, OS, and EFS and is independently associated with better clinical outcome; pathway analyses link it to apoptosis, differentiation, cytokine production, and immune-related processes."	0.7151
31945158	Blood advances	2020	Clinical and functional significance of circular RNAs in cytogenetically normal AML.		circSMC1A	hsa_circ_SMC1A	SMC1A	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	unknown	RT-qPCR; RNA-seq	"circSMC1A is a prognostic circRNA in CN-AML. High expression is associated with longer DFS, OS, and EFS, although the study did not identify distinct downstream gene expression patterns or a specific mechanism."	0.5534
31945158	Blood advances	2020	Clinical and functional significance of circular RNAs in cytogenetically normal AML.		circFCHO2	hsa_circ_FCHO2	FCHO2	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	unknown	RT-qPCR; RNA-seq	"circFCHO2 is a prognostic circRNA in CN-AML. High expression is associated with better outcomes and remains independently associated with longer OS and EFS in multivariable analyses, although no distinct gene expression pattern was found."	0.5534
31945158	Blood advances	2020	Clinical and functional significance of circular RNAs in cytogenetically normal AML.		circFBXW7	hsa_circ_FBXW7	FBXW7	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	unknown	RT-qPCR; RNA-seq	"circFBXW7 functions as a tumor suppressor-like circRNA in AML. Its knockdown increases proliferation of AML cell lines and colony formation by patient AML blasts, and its mechanism is unlikely to involve miRNA sequestration based on lack of detectable miRNA-binding sites."	0.6716
31948317	RNA biology	2020	Genome-wide analysis of circular RNAs involved in Marek's disease tumourigenesis in chickens.	gga_circ_0011261	circZMYM3	gga_circ_ZMYM3	ZMYM3	Marek's disease / MD 	MONDO:0016101	neurolymphomatosis	dysregulated	RNA-seq	circZMYM3 was identified as a dysregulated intronic chicken circRNA in MDV-infected spleen analysis. It was predicted to bind multiple miRNAs and participate in a ceRNA network regulating immune response-related genes such as SWAP70 and CCL4 during Marek's disease tumourigenesis.	0.2414
31948317	RNA biology	2020	Genome-wide analysis of circular RNAs involved in Marek's disease tumourigenesis in chickens.	gga_circ_0014428	circGTDC1	gga_circ_GTDC1	GTDC1	Marek's disease / MD 	MONDO:0016101	neurolymphomatosis	dysregulated	RNA-seq	"circGTDC1 was identified in the predicted DE circRNA/lncRNA-miRNA-mRNA network for MDV-infected chicken spleens. The study predicted that circGTDC1 interacts with gga-miR-155, a hub miRNA connected to immune-related targets such as GATA4."	0.2414
31948317	RNA biology	2020	Genome-wide analysis of circular RNAs involved in Marek's disease tumourigenesis in chickens.	gga_circ_0014634	circMYO1B	gga_circ_MYO1B	MYO1B	Marek's disease / MD 	MONDO:0016101	neurolymphomatosis	dysregulated	RNA-seq	"circMYO1B was identified in the predicted DE circRNA/lncRNA-miRNA-mRNA network for MDV-infected chicken spleens. The study predicted that circMYO1B interacts with gga-miR-155, a hub miRNA connected to immune-related targets such as GATA4."	0.2414
31950540	Cell biochemistry and function	2020	"Circ_LAS1L regulates cardiac fibroblast activation, growth, and migration through miR-125b/SFRP5 pathway."	hsa_circ_0090876	circ_LAS1L	hsa_circ_LAS1L	LAS1L	acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	down-regulated	RT-qPCR	"circ_LAS1L is down-regulated in AMI patients and activated human cardiac fibroblasts. It functions as a miR-125b sponge to promote SFRP5 expression, thereby inhibiting cardiac fibroblast activation, proliferation and migration while promoting apoptosis, suggesting an antifibrotic role after myocardial infarction."	0.7968
31951832	Molecular therapy : the journal of the American Society of Gene Therapy	2020	circCAMSAP1 Promotes Tumor Growth in Colorectal Cancer via the miR-328-5p/E2F1 Axis.	hsa_circ_0001900	CircCAMSAP1	hsa_circ_CAMSAP1	CAMSAP1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circCAMSAP1 is an up-regulated CAMSAP1-derived circRNA in colorectal cancer. It promotes CRC cell proliferation and tumor growth by sponging miR-328-5p and relieving repression of E2F1, while its biogenesis is promoted by ESRP1. Clinically, high circCAMSAP1 expression is associated with advanced stage and poor overall survival, and serum circCAMSAP1 may have diagnostic/prognostic biomarker potential."	0.901
31953159	Life sciences	2020	"Circ_0063517 acts as ceRNA, targeting the miR-31-5p-ETBR axis to regulate angiogenesis of vascular endothelial cells in preeclampsia."	hsa_circ_0063517	circ_0063517			preeclampsia / PE	MONDO:0005081	preeclampsia	down-regulated	RT-qPCR	"circ_0063517 is down-regulated in placenta tissues from PE patients. Functionally, circ_0063517 promotes vascular endothelial cell proliferation, migration and angiogenesis, and enhances placental angiogenesis in an L-NAME-induced PE rat model. Mechanistically, it acts as a ceRNA by sponging miR-31-5p to up-regulate ETBR expression and angiogenesis-related proteins such as VEGF-A and VEGFR2."	0.7554
31954160	Life sciences	2020	Knockdown of circ_0084043 suppresses the development of human melanoma cells through miR-429/tribbles homolog 2 axis and Wnt/beta-catenin pathway.	hsa_circ_0084043	circ_0084043 / CircRNA_0084043			melanoma	MONDO:0005105	melanoma	up-regulated	RT-qPCR	"circ_0084043 is upregulated in human melanoma tissues and cell lines and functions as an oncogenic circRNA. Its knockdown suppresses melanoma proliferation, migration, invasion and xenograft tumor growth while promoting apoptosis, likely through the miR-429/TRIB2 axis and inhibition of Wnt/beta-catenin signaling."	0.7045
31954666	Experimental eye research	2020	Circular RNA-ZNF609 regulates corneal neovascularization by acting as a sponge of miR-184.		Circular RNA-ZNF609 / cZNF609	hsa_circ_ZNF609	ZNF609	corneal neovascularization	MONDO:0006713	corneal neovascularization	up-regulated	RT-qPCR	"cZNF609 is up-regulated during corneal neovascularization and promotes pathological angiogenesis. Mechanistically, it sponges miR-184, relieving miR-184-mediated inhibition of AKT/b-catenin/VEGF signaling and thereby enhancing cell proliferation, migration, and tube formation. Targeting cZNF609 is proposed as a potential therapeutic strategy for pathological corneal neovascularization."	0.6578
31954666	Experimental eye research	2020	Circular RNA-ZNF609 regulates corneal neovascularization by acting as a sponge of miR-184.		Circular RNA-ZNF609 / cZNF609	rno_circ_ZNF609	ZNF609	corneal neovascularization	MONDO:0006713	corneal neovascularization	up-regulated	RT-qPCR	"cZNF609 is up-regulated during corneal neovascularization and promotes pathological angiogenesis. Mechanistically, it sponges miR-184, relieving miR-184-mediated inhibition of AKT/b-catenin/VEGF signaling and thereby enhancing cell proliferation, migration, and tube formation. Targeting cZNF609 is proposed as a potential therapeutic strategy for pathological corneal neovascularization."	0.6578
31960423	Journal of cellular physiology	2020	Circular RNA RSF1 promotes inflammatory and fibrotic phenotypes of irradiated hepatic stellate cell by modulating miR-146a-5p.	hsa_circ_0023706	CircRNA RSF1 / circRSF1	hsa_circ_RSF1	RSF1	radiation-induced liver disease / RILD	MONDO:0043459	radiation-induced disorder	up-regulated	RT-qPCR; Microarray	"circRSF1 is up-regulated in irradiated human hepatic stellate LX2 cells, a cellular model relevant to radiation-induced liver disease. It promotes inflammatory cytokine production, cell viability, and fibrotic activation by sponging miR-146a-5p, thereby relieving repression of RAC1 and activating RAC1-associated NF-kappaB and JNK/Smad2 signaling. The study suggests circRSF1 as a potential therapeutic target for RILD."	0.7296
31960446	Journal of cellular physiology	2020	Circular RNA hsa_circ_0004277 contributes to malignant phenotype of colorectal cancer by sponging miR-512-5p to upregulate the expression of PTMA.	hsa_circ_0004277	circ-0004277			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0004277/circ-0004277 is up-regulated in colorectal cancer tissues and cell lines, and high expression is associated with larger tumor size, advanced TNM stage, and poorer overall survival. Functionally, it promotes CRC cell proliferation and inhibits apoptosis, while knockdown restrains xenograft tumor growth. Mechanistically, circ-0004277 functions as a ceRNA sponge for miR-512-5p to upregulate PTMA expression."	0.7733
31960961	Journal of cellular physiology	2020	CircTIMELESS regulates the proliferation and invasion of lung squamous cell carcinoma cells via the miR-136-5p/ROCK1 axis.	hsa_circ_0000408	circTIMELESS	hsa_circ_TIMELESS	TIMELESS	lung squamous cell carcinoma / LUSC	MONDO:0005097	squamous cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circTIMELESS/hsa_circ_0000408 is upregulated in LUSC tissues and cells and is positively associated with TNM stage. Functionally, circTIMELESS promotes LUSC cell proliferation and invasion, and its silencing suppresses tumor growth in a cell line-derived xenograft model. Mechanistically, circTIMELESS acts as a miR-136-5p sponge to regulate ROCK1 expression through the circTIMELESS/miR-136-5p/ROCK1 axis, suggesting potential therapeutic relevance in LUSC."	0.7785
31960988	Journal of cellular biochemistry	2020	Circular RNA circABCC4 regulates lung adenocarcinoma progression via miR-3186-3p/TNRC6B axis.		circABCC4	hsa_circ_ABCC4	ABCC4	Lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circABCC4 is up-regulated in LUAD tissues and cells and acts as an oncogenic circRNA. Its knockdown suppresses LUAD cell proliferation, migration, invasion, and xenograft tumor growth while promoting apoptosis. Mechanistically, circABCC4 functions as a cytoplasmic ceRNA by sponging miR-3186-3p to positively regulate TNRC6B expression."	0.8355
31960989	Journal of cellular biochemistry	2020	Exosomes from CD133+ cells carrying circ-ABCC1 mediate cell stemness and metastasis in colorectal cancer.	hsa_circ_0000677	circ-ABCC1	hsa_circ_ABCC1	ABCC1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"This study identifies hsa_circ_0000677 (circ-ABCC1) as an upregulated exosomal circRNA in CRC. circ-ABCC1 promotes CRC cell stemness, sphere formation, migration and metastasis, and mechanistically binds beta-catenin to enhance its nuclear accumulation and activate the Wnt/beta-catenin pathway. The authors propose circ-ABCC1 as a potential therapeutic target or biomarker candidate for CRC research."	0.7884
31962276	Cancer genetics	2020	hsa_circ_0062389 promotes the progression of non-small cell lung cancer by sponging miR-103a-3p to mediate CCNE1 expression.	hsa_circ_0062389		hsa_circ_PI4KA	PI4KA	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0062389 is up-regulated in NSCLC tissues and cell lines and is associated with advanced TNM stage, lymph-node metastasis and poor prognosis. Functionally, it promotes NSCLC cell proliferation and cell cycle progression. Mechanistically, it acts as a sponge for miR-103a-3p to increase CCNE1 expression, forming the hsa_circ_0062389/miR-103a-3p/CCNE1 axis."	0.7129
31973814	Biochemical and biophysical research communications	2020	The circular RNA hsa_circ_0007623 acts as a sponge of microRNA-297 and promotes cardiac repair.	hsa_circ_0007623	circRNA_0007623			acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0007623 is up-regulated in hypoxia-induced HUVECs and exerts a protective role in acute myocardial ischemia models. It functions as a miR-297 sponge to relieve repression of VEGFA, thereby promoting endothelial proliferation, migration, angiogenesis, myocardial repair and improved cardiac function."	0.6542
31978512	Gene	2020	ciRS-7 targeting miR-135a-5p promotes neuropathic pain in CCI rats via inflammation and autophagy.		ciRS-7 / CDR1as			neuropathic pain	MONDO:0021667	neuralgia	up-regulated	RT-qPCR	"ciRS-7 is up-regulated in the spinal dorsal horn of CCI rats and is positively associated with neuropathic pain progression. Functionally, ciRS-7 promotes mechanical allodynia and thermal hyperalgesia and increases neuroinflammation and autophagy. Mechanistically, ciRS-7 directly targets miR-135a-5p, forming a circRNA/miRNA/pathway mechanism that regulates inflammation and autophagy in CCI-induced neuropathic pain."	0.6412
31979995	Current eye research	2020	Investigation of circRNA Expression Profiles and Analysis of circRNA-miRNA-mRNA Networks in an Animal (Mouse) Model of Age-Related Macular Degeneration.		mmu_circRNA_20332		Fn1	choroidal neovascularization / CNV	MONDO:0810000	choroidal neovascularization	up-regulated	RT-qPCR; Microarray	mmu_circRNA_20332 was significantly up-regulated in the laser-induced CNV mouse model and validated by qRT-PCR. The study suggests it may contribute to CNV pathogenesis through circRNA-miRNA-mRNA ceRNA network regulation and may serve as a potential therapeutic target in AMD.	0.3684
31979995	Current eye research	2020	Investigation of circRNA Expression Profiles and Analysis of circRNA-miRNA-mRNA Networks in an Animal (Mouse) Model of Age-Related Macular Degeneration.		mmu_circRNA_19388		Scarb1	choroidal neovascularization / CNV	MONDO:0810000	choroidal neovascularization	up-regulated	RT-qPCR; Microarray	mmu_circRNA_19388 was significantly up-regulated in the laser-induced CNV mouse model and validated by qRT-PCR. It interacts with mmu-miR-7012-5p and is included in a circRNA-miRNA-mRNA ceRNA network potentially relevant to CNV pathogenesis.	0.3684
31979995	Current eye research	2020	Investigation of circRNA Expression Profiles and Analysis of circRNA-miRNA-mRNA Networks in an Animal (Mouse) Model of Age-Related Macular Degeneration.		mmu_circRNA_36481		Rad54b	choroidal neovascularization / CNV	MONDO:0810000	choroidal neovascularization	down-regulated	RT-qPCR; Microarray	mmu_circRNA_36481 was significantly down-regulated in the laser-induced CNV mouse model and validated by qRT-PCR. It interacts with mmu-miR-7012-5p and is included in a circRNA-miRNA-mRNA ceRNA network potentially relevant to CNV pathogenesis.	0.3684
31979995	Current eye research	2020	Investigation of circRNA Expression Profiles and Analysis of circRNA-miRNA-mRNA Networks in an Animal (Mouse) Model of Age-Related Macular Degeneration.		mmu_circRNA_006555			choroidal neovascularization / CNV	MONDO:0810000	choroidal neovascularization	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_006555 was significantly down-regulated in the laser-induced CNV mouse model and validated by qRT-PCR. The paper does not report a specific interacting miRNA or downstream target for this circRNA, but it is included among altered circRNAs potentially involved in CNV pathogenesis."	0.3684
31979995	Current eye research	2020	Investigation of circRNA Expression Profiles and Analysis of circRNA-miRNA-mRNA Networks in an Animal (Mouse) Model of Age-Related Macular Degeneration.		mmu_circRNA_012588		Npepps	choroidal neovascularization / CNV	MONDO:0810000	choroidal neovascularization	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_012588 was significantly down-regulated in the laser-induced CNV mouse model and validated by qRT-PCR. It appears among altered circRNAs potentially involved in CNV pathogenesis, but no specific miRNA or downstream effector was reported for it."	0.3684
31979995	Current eye research	2020	Investigation of circRNA Expression Profiles and Analysis of circRNA-miRNA-mRNA Networks in an Animal (Mouse) Model of Age-Related Macular Degeneration.		mmu_circRNA_005578			choroidal neovascularization / CNV	MONDO:0810000	choroidal neovascularization	down-regulated	RT-qPCR; Microarray	"mmu_circRNA_005578 was significantly down-regulated in the laser-induced CNV mouse model and validated by qRT-PCR. No specific miRNA or downstream molecular partner was reported for this circRNA in the paper, but it is part of the altered circRNA set implicated in CNV."	0.3684
31986409	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2020	CircPVT1 contributes to chemotherapy resistance of lung adenocarcinoma through miR-145-5p/ABCC1 axis.		circPVT1	hsa_circ_PVT1	PVT1	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circPVT1 is up-regulated in lung adenocarcinoma tissues and cisplatin/pemetrexed-resistant A549/DR cells. Its high expression is associated with chemotherapy insensitivity and poor prognosis, and circPVT1 promotes chemotherapy resistance by acting as a ceRNA for miR-145-5p to regulate ABCC1."	0.8111
31990052	Journal of cellular physiology	2020	Circular RNA circTET3 mediates migration of rat vascular smooth muscle cells by targeting miR-351-5p.		chr4_115106428_115104274_-2154-Tet3	rno_circ_TET3	tet3	vein graft disease	MONDO:0000001	disease	up-regulated	RT-qPCR; RNA-seq	This study identified rat circTET3 as an up-regulated circRNA in grafted veins during vein graft disease. circTET3 is cytoplasmic and promotes VSMC migration by sponging miR-351-5p and regulating the target gene PTPN1. The circTET3/miR-351-5p/PTPN1 axis was proposed as a potential therapeutic avenue against intimal hyperplasia in vein graft disease.	0.7918
31993998	"Reproductive sciences (Thousand Oaks, Calif.)"	2020	Circular RNA Circ-ITCH Inhibits the Malignant Behaviors of Cervical Cancer by microRNA-93-5p/FOXK2 Axis.		circ-ITCH	hsa_circ_ITCH	ITCH	cervical cancer / CC	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR	"circ-ITCH is down-regulated in cervical cancer and functions as a tumor suppressor. It inhibits proliferation, migration, invasion, and tumor growth by acting as a ceRNA for miR-93-5p and thereby increasing FOXK2 expression."	0.6261
31996784	Oncogene	2020	Targeting the estrogen receptor alpha (ERalpha)-mediated circ-SMG1.72/miR-141-3p/Gelsolin signaling to better suppress the HCC cell invasion.	hsa_circ_0008216	circular RNA-SMG1.72 / circRNA-SMG1.72	hsa_circ_SMG1	SMG1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"In HCC, circRNA-SMG1.72 is elevated and functions as a pro-invasive circRNA. ERalpha suppresses circRNA-SMG1.72 by transcriptional regulation of its host gene SMG1, while circRNA-SMG1.72 sponges miR-141-3p to relieve repression of GSN and promote HCC invasion and metastasis. Targeting the ERalpha/circRNA-SMG1.72/miR-141-3p/GSN axis may help suppress HCC progression, especially in ER-low tumors."	0.8468
31997404	Cell biochemistry and function	2020	Circular RNA CCDC66 facilitates abdominal aortic aneurysm through the overexpression of CCDC66.	hsa_circ_0001312	circRNACCDC66	hsa_circ_CCDC66	CCDC66	abdominal aortic aneurysm / AAA	MONDO:0005350	abdominal aortic aneurysm	up-regulated	RT-qPCR	This study identifies circCCDC66 as an up-regulated circRNA in an AAA-related Angiotensin II-stimulated human VSMC model. circCCDC66 promotes VSMC apoptosis and suppresses proliferation by sponging miR-342-3p and increasing expression of its host gene CCDC66. The circCCDC66/miR-342-3p/CCDC66 axis is proposed as a molecular mechanism contributing to AAA pathogenesis.	0.8118
31999007	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2020	Plasma circular RNA hsa_circ_0001445 and coronary artery disease: Performance as a biomarker.	hsa_circ_0001445	circSMARCA5	hsa_circ_SMARCA5	SMARCA5	coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	down-regulated	RT-qPCR	This study evaluated plasma hsa_circ_0001445/circSMARCA5 as a circulating biomarker for stable coronary artery disease. Lower plasma levels were associated with higher coronary atherosclerotic burden and improved patient reclassification when added to clinical risk models. In vitro experiments suggested that atherogenic conditions reduce hsa_circ_0001445 levels in extracellular vesicles secreted by human coronary smooth muscle cells.	0.6238
32001271	Life sciences	2020	Microarray analysis of circRNAs expression profile in gliomas reveals that circ_0037655 could promote glioma progression by regulating miR-214/PI3K signaling.	hsa_circ_0037655	circ_0037655			glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; Microarray	"circ_0037655 is up-regulated in glioma tissues and U251/SHG-44 glioma cells. It promotes glioma cell viability, invasion and xenograft tumor growth by sponging miR-214 and modulating PI3K/AKT signaling, and its expression showed diagnostic potential."	0.817
32001271	Life sciences	2020	Microarray analysis of circRNAs expression profile in gliomas reveals that circ_0037655 could promote glioma progression by regulating miR-214/PI3K signaling.	hsa_circ_0001836	circ_0001836			glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; Microarray	"circ_0001836 was identified as an up-regulated circRNA in glioma tissues by microarray and showed a consistent expression pattern in qRT-PCR validation, but no functional mechanism was investigated."	0.5135
32001271	Life sciences	2020	Microarray analysis of circRNAs expression profile in gliomas reveals that circ_0037655 could promote glioma progression by regulating miR-214/PI3K signaling.	hsa_circ_0046701	circ_0046701			glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; Microarray	"circ_0046701 was identified as an up-regulated circRNA in glioma tissues by microarray and showed a consistent expression pattern in qRT-PCR validation, but no functional mechanism was investigated."	0.5135
32001271	Life sciences	2020	Microarray analysis of circRNAs expression profile in gliomas reveals that circ_0037655 could promote glioma progression by regulating miR-214/PI3K signaling.	hsa_circ_0021789	circ_0021789			glioma	MONDO:0021042	glioma	down-regulated	RT-qPCR; Microarray	"circ_0021789 was identified as a down-regulated circRNA in glioma tissues by microarray and showed a consistent expression pattern in qRT-PCR validation, but no functional mechanism was investigated."	0.5135
32001271	Life sciences	2020	Microarray analysis of circRNAs expression profile in gliomas reveals that circ_0037655 could promote glioma progression by regulating miR-214/PI3K signaling.	hsa_circ_0001649	circ_0001649			glioma	MONDO:0021042	glioma	down-regulated	RT-qPCR; Microarray	"circ_0001649 was identified as a down-regulated circRNA in glioma tissues by microarray and showed a consistent expression pattern in qRT-PCR validation, but no functional mechanism was investigated."	0.5135
32001271	Life sciences	2020	Microarray analysis of circRNAs expression profile in gliomas reveals that circ_0037655 could promote glioma progression by regulating miR-214/PI3K signaling.	hsa_circ_0005779	circ_0005779			glioma	MONDO:0021042	glioma	down-regulated	RT-qPCR; Microarray	"circ_0005779 was identified as a down-regulated circRNA in glioma tissues by microarray and showed a consistent expression pattern in qRT-PCR validation, but no functional mechanism was investigated."	0.5135
32003018	Journal of cellular physiology	2020	CircBACH1 (hsa_circ_0061395) promotes hepatocellular carcinoma growth by regulating p27 repression via HuR.	hsa_circ_0061395	circBACH1	hsa_circ_BACH1	BACH1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circBACH1 (hsa_circ_0061395) is upregulated in HCC tissues and cell lines, and high expression predicts poor prognosis. Functionally, it promotes HCC proliferation, cell cycle progression, and xenograft tumor growth. Mechanistically, circBACH1 binds HuR and promotes its cytoplasmic accumulation, thereby repressing p27 translation through the circBACH1/HuR/p27 axis."	0.8743
32010565	Translational lung cancer research	2019	Circ-ZKSCAN1 regulates FAM83A expression and inactivates MAPK signaling by targeting miR-330-5p to promote non-small cell lung cancer progression.	hsa_circ_0001727	circ_ZKSCAN1 / circZKSCAN1	hsa_circ_ZKSCAN1	ZKSCAN1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"Circ-ZKSCAN1 (hsa_circ_0001727), derived from ZKSCAN1, is up-regulated in NSCLC tissues and cell lines and high expression is linked to larger tumors, advanced clinical stage and poorer survival. Functionally, it promotes NSCLC proliferation, migration, invasion and xenograft tumor growth and suppresses apoptosis. Mechanistically, circ-ZKSCAN1 sponges miR-330-5p to increase FAM83A expression, forming a feedback loop that inhibits MAPK/ERK signaling and promotes NSCLC progression."	0.7794
32010569	Translational lung cancer research	2019	Prognostic model based on circular RNA circPDK1 for resected lung squamous cell carcinoma.		circPDK1 / circular RNA pyruvate dehydrogenase kinase 1	hsa_circ_PDK1		lung squamous cell carcinoma / LUSC	MONDO:0005097	squamous cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"circPDK1 is a PDK1-derived circular RNA that is up-regulated in resected LSCC tissues compared with adjacent normal lung tissues. Higher circPDK1 expression was associated with fewer metastatic/invasive clinicopathological features and better RFS/OS, and it was incorporated with T staging, lymph node status, age, and SCCAg into a prognostic nomogram for 5-year RFS and OS prediction. The study did not define a detailed molecular mechanism."	0.5202
32012318	Clinical and experimental pharmacology & physiology	2020	Knockdown of circular RNA UBAP2 inhibits the malignant behaviours of esophageal squamous cell carcinoma by microRNA-422a/Rab10 axis.		Circular RNA UBAP2 / circUBAP2	hsa_circ_UBAP2	UBAP2	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"This study reports that circUBAP2 is upregulated in ESCC tumour tissues and ESCC cell lines. Functional assays indicate that circUBAP2 promotes ESCC cell proliferation, migration, invasion and xenograft tumour growth. Mechanistically, circUBAP2 acts as an oncogenic ceRNA by sponging miR-422a and regulating Rab10, suggesting potential therapeutic relevance in ESCC."	0.6521
32014458	Cancer letters	2020	Exosome-transmitted circular RNA hsa_circ_0051443 suppresses hepatocellular carcinoma progression.	hsa_circ_0051443	circ-0051443			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq; Microarray	"hsa_circ_0051443/circ-0051443 is down-regulated in HCC tissues and plasma exosomes. Normal liver cell-derived exosomes can transmit circ-0051443 to HCC cells, where it suppresses proliferation and tumor growth, promotes apoptosis, and arrests the cell cycle. Mechanistically, exosomal circ-0051443 acts as a ceRNA for miR-331-3p to upregulate BAK1 and may serve as a diagnostic biomarker and therapeutic target for HCC."	0.8423
32014687	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2020	Overexpression of circRNA_100290 promotes the progression of laryngeal squamous cell carcinoma through the miR-136-5p/RAP2C axis.		circRNA_100290	hsa_circ_SLC30A7	SLC30A7	laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR	"circRNA_100290 is upregulated in LSCC tissues and cell lines and is associated with advanced TNM stage and lymph node metastasis. It promotes malignant LSCC phenotypes including proliferation, colony formation, migration, invasion and xenograft tumor growth, while suppressing apoptosis. Mechanistically, it functions as a ceRNA for miR-136-5p to upregulate RAP2C."	0.6544
32017171	Clinical and experimental pharmacology & physiology	2020	Downregulation of circular RNA circPVT1 restricts cell growth of hepatocellular carcinoma through downregulation of Sirtuin 7 via microRNA-3666.		circular RNA PVT1 / circPVT1	hsa_circ_PVT1	PVT1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circPVT1 is upregulated in HCC tissues and cell lines and acts as an oncogenic circRNA that promotes HCC cell growth and colony formation while suppressing apoptosis. Mechanistically, circPVT1 sponges miR-3666 to relieve repression of SIRT7, thereby contributing to HCC cell growth and modulation of p53 signaling. The study suggests circPVT1 and the circPVT1/miR-3666/SIRT7 axis as potential therapeutic targets for HCC."	0.7032
32018039	Bone	2020	Circular RNA CDR1as promotes adipogenic and suppresses osteogenic differentiation of BMSCs in steroid-induced osteonecrosis of the femoral head.	hsa_circ_0001946	Circular RNA CDR1as / CDR1as	hsa_circ_CDR1as	CDR1	osteonecrosis	MONDO:0005380	osteonecrosis	up-regulated	RT-qPCR; Microarray	"CDR1as is significantly up-regulated in SONFH-BMSCs and functions as a miR-7-5p sponge to increase WNT5B expression. This promotes adipogenic differentiation and suppresses osteogenic differentiation, likely through the WNT5B/beta-catenin-related pathway, making CDR1as a potential diagnostic and therapeutic biomarker for SONFH."	0.5627
32020707	Journal of biochemical and molecular toxicology	2020	Circular RNA circHIAT1 inhibits proliferation and epithelial-mesenchymal transition of gastric cancer cell lines through downregulation of miR-21.		circHIAT1 / CircRNA Hippocampus Abundant Transcript 1	hsa_circ_HIAT1	HIAT1	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"In this study, circHIAT1 was down-regulated in gastric cancer tissues and acted as a tumor suppressor in MKN28 and MKN45 gastric cancer cells. circHIAT1 overexpression inhibited proliferation and EMT, promoted apoptosis, and suppressed PTEN/PI3K/AKT and ERK signaling by downregulating miR-21, suggesting therapeutic potential in gastric cancer."	0.5358
32026471	Journal of cellular physiology	2020	circ-CEP85L suppresses the proliferation and invasion of gastric cancer by regulating NFKBIA expression via miR-942-5p.	hsa_circ_0077736	circ-CEP85L	hsa_circ_CEP85L	CEP85L	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"circ-CEP85L is downregulated in gastric cancer tissues and low expression is associated with worse prognosis. Functionally, circ-CEP85L suppresses GC cell proliferation, migration, invasion, and in vivo tumor growth. Mechanistically, it acts as a ceRNA for miR-942-5p to promote NFKBIA expression, suggesting potential therapeutic relevance in GC."	0.8155
32037619	Journal of cellular biochemistry	2020	Circ-HOMER1 enhances the inhibition of miR-1322 on CXCL6 to regulate the growth and aggressiveness of hepatocellular carcinoma cells.	hsa_circ_0006916	circ-HOMER1 / circular-HOMER1	hsa_circ_HOMER1	HOMER1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ-HOMER1 is up-regulated in HCC tissues and cell lines and is associated with larger tumor size, advanced TNM stage, and poorer overall survival. Functionally, it promotes HCC cell proliferation, migration, invasion and aggressiveness while suppressing apoptosis. Mechanistically, cytoplasmic circ-HOMER1 sponges miR-1322 to increase CXCL6 expression, forming a circ-HOMER1/miR-1322/CXCL6 regulatory axis."	0.7628
32044717	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2020	CircRBM33 regulates IL-6 to promote gastric cancer progression through targeting miR-149.	hsa_circ_0001772	circRBM33	hsa_circ_RBM33	RBM33	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"hsa_circ_0001772/circRBM33 is upregulated in gastric cancer tissues and cell lines and is associated with more aggressive clinicopathological features. Functionally, circRBM33 promotes GC cell proliferation, migration and invasion while suppressing apoptosis. Mechanistically, circRBM33 binds miR-149 and modulates IL-6 levels through the circRBM33/miR-149/IL-6 axis, suggesting potential biomarker and therapeutic relevance."	0.6536
32045642	Microbial pathogenesis	2020	Neisseria gonorrhoeae-induced salpingitis is targeted by circular RNA EIF3K via miR-139-5p and regulating MAPK/NF-kappaB signaling pathway to promotes apoptosis and autophagy bacterial cells.		circular RNA EIF3K / circEIF3K	hsa_circ_EIF3K	EIF3K	salpingitis	MONDO:0003619	salpingitis	down-regulated	RT-qPCR	"Circular RNA EIF3K is down-regulated in Neisseria gonorrhoeae-induced inflammatory tubal epithelial cells. In this study, overexpressed circEIF3K inhibited cell viability/proliferation and promoted apoptosis and autophagy, likely by sponging miR-139-5p and suppressing MAPK/NF-kappaB signaling. The authors propose EIF3K as a potential biomarker or therapeutic factor for salpingitis research."	0.5416
32046405	"Reproductive sciences (Thousand Oaks, Calif.)"	2020	Hsa_circ_CSPP1/MiR-361-5p/ITGB1 Regulates Proliferation and Migration of Cervical Cancer (CC) by Modulating the PI3K-Akt Signaling Pathway.	hsa_circ_0136959	circular RNA CSPP1	hsa_circ_CSPP1	CSPP1	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_CSPP1 is upregulated in cervical cancer tissues and cell lines. It promotes cervical cancer proliferation, migration, and xenograft tumor growth while inhibiting apoptosis, at least partly by sponging miR-361-5p to regulate ITGB1 and activate the PI3K-Akt pathway."	0.6829
32046413	"Reproductive sciences (Thousand Oaks, Calif.)"	2020	Circular RNA-ITCH Inhibits the Proliferation of Ovarian Carcinoma by Downregulating lncRNA HULC.		circular RNA-ITCH / ITCH	hsa_circ_ITCH	ITCH	ovarian cancer / OC	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR	"Circular RNA-ITCH is downregulated in ovarian carcinoma tissues. Its overexpression inhibits ovarian carcinoma cell proliferation, at least partly by downregulating the lncRNA HULC, while it does not significantly affect migration or invasion in the tested cell lines."	0.6099
32046858	Biochemical and biophysical research communications	2020	CircHIPK3 promotes colorectal cancer cells proliferation and metastasis via modulating of miR-1207-5p/FMNL2 signal.		circRNA HIPK3 / circHIPK3	hsa_circ_HIPK3	HIPK3	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in colorectal cancer tissues and cell lines, and high expression is associated with unfavorable clinicopathological features and poorer survival. Functionally, circHIPK3 promotes CRC cell proliferation, migration and invasion by sponging miR-1207-5p and enhancing FMNL2 protein expression, suggesting the circHIPK3/miR-1207-5p/FMNL2 axis as a potential therapeutic target."	0.8323
32048412	"BioFactors (Oxford, England)"	2023	Circular RNA-0072309 has antitumor influences in Hep3B cell line by targeting microRNA-665.		circRNA-0072309			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"CircRNA-0072309 is down-regulated in liver cancer tissues and HCC cell lines, and higher expression is associated with better 5-year survival. Functionally, it suppresses Hep3B cell viability, colony formation, migration and invasion while promoting apoptosis. Mechanistically, circRNA-0072309 targets miR-665 and deactivates PI3K/AKT and Wnt/beta-catenin signaling pathways."	0.7126
32048451	The journal of obstetrics and gynaecology research	2020	Circular RNA PVT1 enhances cell proliferation but inhibits apoptosis through sponging microRNA-149 in epithelial ovarian cancer.		circular RNA PVT1 / circ-PVT1	hsa_circ_PVT1	PVT1	epithelial ovarian cancer / EOC	MONDO:0005140	ovarian carcinoma	up-regulated	RT-qPCR	"In this study, circ-PVT1 was up-regulated in human epithelial ovarian cancer cell lines compared with normal ovarian surface epithelial cells. Functional assays showed that circ-PVT1 promotes EOC cell proliferation and inhibits apoptosis. Mechanistically, circ-PVT1 directly sponges and negatively regulates miR-149, suggesting a potential therapeutic target role in EOC."	0.6263
32050790	Epigenomics	2020	CircRNA hsa_circ_0004771 promotes esophageal squamous cell cancer progression via miR-339-5p/CDC25A axis.	hsa_circ_0000437	circ_0000437			esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa circ 0000437 was identified from plasma RNA-seq and validated by qRT-PCR as upregulated in ESCC plasma and tissue sample groups. ROC analysis suggested diagnostic biomarker potential, but the study did not report mechanistic or functional assays for this circRNA."	0.4679
32050790	Epigenomics	2020	CircRNA hsa_circ_0004771 promotes esophageal squamous cell cancer progression via miR-339-5p/CDC25A axis.	hsa_circ_0004771	circ_0004771	hsa_circ_NRIP1	NRIP1	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0004771 is upregulated in ESCC plasma and tumor tissues and high plasma expression predicts poorer OS and DFS. Functionally, it promotes ESCC proliferation, migration, invasion and in vivo tumor growth. Mechanistically, it mainly localizes in the cytoplasm and acts through a miR-339-5p/CDC25A axis, with evidence suggesting tumor-derived exosomal contribution to its plasma abundance."	0.8867
32052496	Journal of cellular biochemistry	2020	Identification of downregulated circRNAs from tissue and plasma of patients with gastric cancer and construction of a circRNA-miRNA-mRNA network.	hsa_circ_0001190				gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	hsa_circ_0001190 was identified as downregulated in both gastric cancer tissue and plasma and was confirmed as lower in MGC-803 gastric cancer cells than in GES-1 cells. The study proposes it as a potential plasma biomarker and predicted ceRNA regulator in gastric cancer through miRNA-hub gene networks.	0.4032
32052496	Journal of cellular biochemistry	2020	Identification of downregulated circRNAs from tissue and plasma of patients with gastric cancer and construction of a circRNA-miRNA-mRNA network.	hsa_circ_0036287				gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	hsa_circ_0036287 was identified as downregulated in both gastric cancer tissue and plasma and was confirmed as lower in MGC-803 gastric cancer cells than in GES-1 cells. The study proposes it as a newly reported potential plasma biomarker and predicted ceRNA regulator in gastric cancer.	0.4032
32052496	Journal of cellular biochemistry	2020	Identification of downregulated circRNAs from tissue and plasma of patients with gastric cancer and construction of a circRNA-miRNA-mRNA network.	hsa_circ_0048607				gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	hsa_circ_0048607 was identified as downregulated in both gastric cancer tissue and plasma and was confirmed as lower in MGC-803 gastric cancer cells than in GES-1 cells. The study proposes it as a newly reported potential plasma biomarker and predicted ceRNA regulator in gastric cancer.	0.4032
32052578	EMBO reports	2020	Androgen receptor-regulated circFNTA activates KRAS signaling to promote bladder cancer invasion.	hsa_circ_0084171	circFNTA / circ_0084171	hsa_circ_FNTA	FNTA	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; ISH	"circFNTA is up-regulated in bladder cancer tissues and cell lines. It promotes bladder cancer invasion, metastasis, and cisplatin chemo-resistance through an AR/ADAR2/circFNTA/miR-370-3p/FNTA/KRAS signaling axis, and circFNTA depletion suppresses tumor growth and lung metastasis in vivo."	0.8322
32052645	"Artificial cells, nanomedicine, and biotechnology"	2020	Circular RNA cZNF292 silence alleviates OGD/R-induced injury through up-regulation of miR-22 in rat neural stem cells (NSCs).		cZNF292	rno_circ_ZNF292	ZNF292	Hypoxic-ischaemic encephalopathy / HIE	MONDO:0005299	brain ischemia	up-regulated	RT-qPCR	"In rat neural stem cells, OGD/R treatment up-regulates cZNF292. cZNF292 aggravates OGD/R-induced injury by reducing cell viability and promoting apoptosis, while cZNF292 silencing protects NSCs through up-regulation of miR-22 and activation of Wnt/b-catenin and PKC/ERK pathways. The study suggests cZNF292 silencing as a potential therapeutic strategy for HIE."	0.414
32060230	Molecular cancer research : MCR	2020	Circular RNA hsa_circ_0014130 Inhibits Apoptosis in Non-Small Cell Lung Cancer by Sponging miR-136-5p and Upregulating BCL2.	hsa_circ_0014130	circRNA circPIP5K1A	hsa_circ_PIP5K1A	PIP5K1A	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0014130 is up-regulated in NSCLC tissues and acts as an oncogenic circRNA. It promotes NSCLC cell proliferation, invasion and xenograft tumor growth, at least partly by sponging miR-136-5p and increasing Bcl-2 expression to inhibit apoptosis. Its expression has diagnostic/prognostic relevance and may serve as a biomarker or therapeutic target."	0.7369
32065448	Journal of cellular biochemistry	2020	Circular RNA (circ-0075804) promotes the proliferation of retinoblastoma via combining heterogeneous nuclear ribonucleoprotein K (HNRNPK) to improve the stability of E2F transcription factor 3 E2F3.		circ-0075804	hsa_circ_E2F3	E2F3	retinoblastoma / RB	MONDO:0008380	retinoblastoma	up-regulated	RT-qPCR	"circ-0075804 is up-regulated in retinoblastoma cells and primary RB tissues. It promotes RB cell proliferation and suppresses apoptosis by binding the RBP HNRNPK and enhancing E2F3 mRNA stability, suggesting potential therapeutic relevance."	0.8331
32070139	"Artificial cells, nanomedicine, and biotechnology"	2020	Silencing circular RNA-ZNF652 represses proliferation and EMT process of renal carcinoma cells via raising miR-205.		circ-ZNF652 / circular RNA-ZNF652	hsa_circ_ZNF652	ZNF652	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR	"circ-ZNF652 is up-regulated in renal carcinoma tissues and functions as an oncogenic circRNA. Silencing circ-ZNF652 inhibits proliferation and EMT while promoting apoptosis in A498 and ACHN renal carcinoma cells, partly through suppression of Ras/Raf/MEK/ERK and JAK1/STAT3 pathways and up-regulation of miR-205."	0.5358
32079426	Epigenomics	2020	RNA-Seq profiling of circular RNAs in human small cell lung cancer.		circ-THRAP3	hsa_circ_THRAP3	THRAP3	small cell lung cancer / SCLC	MONDO:0008433	small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ-THRAP3 was identified by circRNA-seq and validated by qRT-PCR as significantly upregulated in SCLC tissues. It was also upregulated in NSCLC samples and showed higher expression in SCLC than NSCLC, suggesting potential diagnostic relevance."	0.4685
32079426	Epigenomics	2020	RNA-Seq profiling of circular RNAs in human small cell lung cancer.		circ-SEC31A	hsa_circ_SEC31A	SEC31A	small cell lung cancer / SCLC	MONDO:0008433	small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ-SEC31A was identified by circRNA-seq and validated by qRT-PCR as significantly upregulated in SCLC tissues. It was also upregulated in NSCLC samples and showed higher expression in SCLC than NSCLC, suggesting potential diagnostic relevance."	0.4685
32079426	Epigenomics	2020	RNA-Seq profiling of circular RNAs in human small cell lung cancer.		circ-SATB1	hsa_circ_SATB1	SATB1	small cell lung cancer / SCLC	MONDO:0008433	small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ-SATB1 was identified and qRT-PCR validated as upregulated in most SCLC tissues. Unlike several other upregulated circRNAs, it was not altered in NSCLC, and the authors proposed that it may complement circ-STXBP5L for distinguishing SCLC from NSCLC."	0.4685
32079426	Epigenomics	2020	RNA-Seq profiling of circular RNAs in human small cell lung cancer.		circ-VAPA	hsa_circ_VAPA	VAPA	small cell lung cancer / SCLC	MONDO:0008433	small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ-VAPA was identified by circRNA-seq and validated by qRT-PCR as significantly upregulated in SCLC tissues. It was also upregulated in NSCLC samples and showed higher expression in SCLC than NSCLC, suggesting potential diagnostic relevance."	0.4685
32079426	Epigenomics	2020	RNA-Seq profiling of circular RNAs in human small cell lung cancer.		circ-STXBP5L	hsa_circ_STXBP5L	STXBP5L	small cell lung cancer / SCLC	MONDO:0008433	small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ-STXBP5L was selectively upregulated in SCLC tissues, absent from normal controls, and weak or absent in most NSCLC samples. The study confirmed its circular structure and cytoplasmic localization, and proposed a miRNA sponge mechanism involving hsa-miR-224-3p and hsa-miR-512-3p that may regulate SCLC pathway genes and contribute to SCLC tumorigenesis."	0.6333
32079426	Epigenomics	2020	RNA-Seq profiling of circular RNAs in human small cell lung cancer.		circ-TBX5	hsa_circ_TBX5	TBX5	small cell lung cancer / SCLC	MONDO:0008433	small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	circ-TBX5 was among the randomly selected downregulated circRNAs whose decreased expression in SCLC tissues was confirmed by qRT-PCR. The study did not further characterize its mechanism or function.	0.4685
32079426	Epigenomics	2020	RNA-Seq profiling of circular RNAs in human small cell lung cancer.		circ-WDR60	hsa_circ_WDR60	WDR60	small cell lung cancer / SCLC	MONDO:0008433	small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	circ-WDR60 was among the randomly selected downregulated circRNAs whose decreased expression in SCLC tissues was confirmed by qRT-PCR. The study did not further characterize its mechanism or function.	0.4685
32079426	Epigenomics	2020	RNA-Seq profiling of circular RNAs in human small cell lung cancer.		circ-CARD6	hsa_circ_CARD6	CARD6	small cell lung cancer / SCLC	MONDO:0008433	small cell lung carcinoma	down-regulated	RT-qPCR; RNA-seq	circ-CARD6 was among the randomly selected downregulated circRNAs whose decreased expression in SCLC tissues was confirmed by qRT-PCR. The study did not further characterize its mechanism or function.	0.4685
32087327	The international journal of biochemistry & cell biology	2020	Circular RNA hsa_circ_0076906 competes with OGN for miR-1305 biding site to alleviate the progression of osteoporosis.	hsa_circ_0076906	circ_0076906			osteoporosis / OP	MONDO:0005298	osteoporosis	down-regulated	RT-qPCR	"hsa_circ_0076906 is down-regulated in bone tissue and serum from osteoporosis patients and is induced during osteogenic differentiation of hMSCs. It primarily localizes to the cytoplasm, where it sponges miR-1305 and competes with OGN for miR-1305 binding, thereby increasing OGN expression and promoting osteogenic differentiation. The study suggests hsa_circ_0076906 may serve as a diagnostic and therapeutic target for osteoporosis."	0.6432
32089501	Annals of hepatology	2020	"Circ-PRMT5 enhances the proliferation, migration and glycolysis of hepatoma cells by targeting miR-188-5p/HK2 axis."	hsa_circ_0031242	circ-PRMT5	hsa_circ_PRMT5	PRMT5	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ-PRMT5 is upregulated in HCC tissues and cell lines. It promotes HCC cell proliferation, migration, glycolysis and xenograft tumor growth by sponging miR-188-5p and increasing HK2 expression, suggesting the circ-PRMT5/miR-188-5p/HK2 axis as a potential therapeutic target."	0.7785
32097101	Radiation research	2020	Circular RNA TUBD1 Acts as the miR-146a-5p Sponge to Affect the Viability and Pro-Inflammatory Cytokine Production of LX-2 Cells through the TLR4 Pathway.	hsa_circ_0044897	circTUBD1	hsa_circ_TUBD1	TUBD1	radiation-induced liver disease / RILD	MONDO:0043459	radiation-induced disorder	up-regulated	RT-qPCR; Microarray	"circTUBD1 is up-regulated in irradiated and LPS-stimulated human hepatic stellate LX-2 cells, a cellular model relevant to RILD. It functions as a sponge for miR-146a-5p and promotes LX-2 cell viability and pro-inflammatory cytokine production through activation of the TLR4/NF-kappaB-related pathway; knockdown of circTUBD1 suppresses proliferation and inflammatory cytokine secretion while promoting apoptosis."	0.7949
32104945	"BioFactors (Oxford, England)"	2020	CircPRKCI relieves lipopolysaccharide-induced HK2 cell injury by upregulating the expression of miR-545 target gene ZEB2.		circPRKCI	hsa_circ_PRKCI	PRKCI	acute kidney injury / AKI	MONDO:0002492	acute kidney injury	down-regulated	RT-qPCR	"circPRKCI is down-regulated in serum from urosepsis patients and in LPS-treated HK2 cells. Functionally, circPRKCI overexpression protects HK2 cells from LPS-induced injury by improving viability, suppressing apoptosis, and reducing inflammatory cytokines. Mechanistically, circPRKCI acts through the miR-545/ZEB2 axis and inhibits NF-kB pathway activation."	0.6521
32113679	Biochemical and biophysical research communications	2020	Circular RNA circ-RELL1 regulates inflammatory response by miR-6873-3p/MyD88/NF-kappaB axis in endothelial cells.	hsa_circ_0002194	circ-RELL1	hsa_circ_RELL1	RELL1	atherosclerotic cardiovascular disease / ASCVD	MONDO:1060134	atherosclerotic cardiovascular disease	up-regulated	RT-qPCR; Microarray	"circ-RELL1/hsa_circ_0002194 is up-regulated in ox-LDL-stimulated HUVECs and promotes endothelial inflammation. Mechanistically, it sponges miR-6873-3p in the cytoplasm, thereby increasing MyD88-mediated NF-kB activation and ICAM1/VCAM1 expression."	0.6491
32113679	Biochemical and biophysical research communications	2020	Circular RNA circ-RELL1 regulates inflammatory response by miR-6873-3p/MyD88/NF-kappaB axis in endothelial cells.	hsa_circ_0092316				atherosclerotic cardiovascular disease / ASCVD	MONDO:1060134	atherosclerotic cardiovascular disease	up-regulated	RT-qPCR; Microarray	"hsa_circ_0092316 was among the top five circRNAs reported as up-regulated in ox-LDL-stimulated HUVECs, but the study did not characterize its mechanism or biological function."	0.1904
32113679	Biochemical and biophysical research communications	2020	Circular RNA circ-RELL1 regulates inflammatory response by miR-6873-3p/MyD88/NF-kappaB axis in endothelial cells.	hsa_circ_0004831				atherosclerotic cardiovascular disease / ASCVD	MONDO:1060134	atherosclerotic cardiovascular disease	up-regulated	RT-qPCR; Microarray	"hsa_circ_0004831 was among the top five circRNAs reported as up-regulated in ox-LDL-stimulated HUVECs, but the study did not characterize its mechanism or biological function."	0.1904
32113679	Biochemical and biophysical research communications	2020	Circular RNA circ-RELL1 regulates inflammatory response by miR-6873-3p/MyD88/NF-kappaB axis in endothelial cells.	hsa_circ_0040824				atherosclerotic cardiovascular disease / ASCVD	MONDO:1060134	atherosclerotic cardiovascular disease	up-regulated	RT-qPCR; Microarray	"hsa_circ_0040824 was among the top five circRNAs reported as up-regulated in ox-LDL-stimulated HUVECs, but the study did not characterize its mechanism or biological function."	0.1904
32113679	Biochemical and biophysical research communications	2020	Circular RNA circ-RELL1 regulates inflammatory response by miR-6873-3p/MyD88/NF-kappaB axis in endothelial cells.	hsa_circ_0011785				atherosclerotic cardiovascular disease / ASCVD	MONDO:1060134	atherosclerotic cardiovascular disease	up-regulated	RT-qPCR; Microarray	"hsa_circ_0011785 was among the top five circRNAs reported as up-regulated in ox-LDL-stimulated HUVECs, but the study did not characterize its mechanism or biological function."	0.1904
32115780	Journal of cellular biochemistry	2020	Identification of functional circRNA/miRNA/mRNA regulatory network for exploring prospective therapy strategy of colorectal cancer.	hsa_circ_0030632		hsa_circ_UGGT2	UGGT2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0030632 is an up-regulated circRNA in CRC tissues and cell lines validated by qPCR. The study predicts that it acts through a circRNA/miRNA/mRNA regulatory network and may have an oncogenic role by regulating telomere maintenance, posttranslational protein folding, anti-apoptotic processes and metabolic programs."	0.585
32115780	Journal of cellular biochemistry	2020	Identification of functional circRNA/miRNA/mRNA regulatory network for exploring prospective therapy strategy of colorectal cancer.	hsa_circ_0004887		hsa_circ_AURKA	AURKA	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0004887 is up-regulated in CRC according to RNA-seq/GEO intersection and qPCR results, although its expression level was reported to be low and difficult to detect. The study predicts that it may function in CRC through a circRNA/miRNA/mRNA ceRNA network involving apoptotic and metabolic processes."	0.585
32115780	Journal of cellular biochemistry	2020	Identification of functional circRNA/miRNA/mRNA regulatory network for exploring prospective therapy strategy of colorectal cancer.	hsa_circ_0001550		hsa_circ_RARS	RARS	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0001550 is significantly up-regulated in CRC tissues and CRC cell lines. The study predicts that it functions within a circRNA/miRNA/mRNA regulatory network and may participate in anti-apoptotic and metabolic processes relevant to CRC progression.	0.585
32115780	Journal of cellular biochemistry	2020	Identification of functional circRNA/miRNA/mRNA regulatory network for exploring prospective therapy strategy of colorectal cancer.	hsa_circ_0001681		hsa_circ_RAPGEF5	RAPGEF5	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0001681 is significantly up-regulated in CRC tissues and CRC cell lines. The study predicts that it functions as part of a circRNA/miRNA/mRNA regulatory network and may be involved in anti-apoptotic and metabolic processes in CRC.	0.585
32116112	"Cell cycle (Georgetown, Tex.)"	2020	Oncogenic hsa_circ_0091581 promotes the malignancy of HCC cell through blocking miR-526b from degrading c-MYC mRNA.	hsa_circ_0091581		hsa_circ_GPC3	GPC3	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0091581 is upregulated in HCC tissues and cell lines, and high expression is associated with larger tumor size and worse DFS/OS. Functionally, it promotes HCC cell proliferation by sponging miR-526b and relieving repression of c-Myc, forming a positive feedback loop in which c-Myc also upregulates hsa_circ_0091581. The study suggests hsa_circ_0091581 as a potential prognostic biomarker and therapeutic target for HCC."	0.7968
32119786	Cancer biotherapy & radiopharmaceuticals	2021	Circ_0000388 Exerts Oncogenic Function in Cervical Cancer Cells by Regulating miR-337-3p/TCF12 Axis.	hsa_circ_0000388	circ_0000388			cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ_0000388 is upregulated in cervical cancer tissues and cell lines and is associated with advanced clinicopathological features. Functionally, it promotes proliferation, migration, invasion and metastasis while inhibiting apoptosis of cervical cancer cells. Mechanistically, circ_0000388 sponges miR-337-3p to increase TCF12 expression, forming a circ_0000388/miR-337-3p/TCF12 oncogenic axis."	0.7045
32130980	Gene	2020	Circular RNA 0060428 sponges miR-375 to promote osteosarcoma cell proliferation by upregulating the expression of RPBJ.	hsa_circ_0060428	circ-00600428			osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"This study found that circ-0060428 is up-regulated in osteosarcoma cell lines and is mainly localized in the cytoplasm. Functionally, circ-0060428 promotes osteosarcoma cell proliferation and survival while inhibiting apoptosis. Mechanistically, circ-0060428 sponges miR-375 to upregulate RBPJ expression and modulate apoptosis-related proteins, suggesting it may be a therapeutic target or biomarker for osteosarcoma."	0.6683
32140899	Cellular and molecular neurobiology	2020	Silencing of circFoxO3 Protects HT22 Cells from Glutamate-Induced Oxidative Injury via Regulating the Mitochondrial Apoptosis Pathway.		FoxO3 circular RNA / circFoxO3	mmu_circ_FoxO3	FoxO3	neurodegenerative diseases	MONDO:0005559	neurodegenerative disease	up-regulated	RT-qPCR; ISH	"This study found that circFoxO3 is up-regulated in glutamate-treated mouse HT22 neuronal cells, a model of neurodegenerative oxidative injury. circFoxO3 promotes oxidative stress-related mitochondrial apoptosis through the FoxO3/Bim EL and Cytochrome c/Caspase-3 mitochondrial apoptotic pathway, while circFoxO3 knockdown reduces ROS accumulation, MMP loss, apoptosis, and cell death. The authors suggest circFoxO3 as a potential diagnostic marker and therapeutic target for neurodegenerative diseases."	0.5627
32151944	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2020	STAT3-induced upregulation of circCCDC66 facilitates the progression of non-small cell lung cancer by targeting miR-33a-5p/KPNA4 axis.		circCCDC66	hsa_circ_CCDC66	CCDC66	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circCCDC66 is up-regulated in NSCLC cells and functions as an oncogenic circRNA that promotes proliferation, migration, invasion, tumor growth and tumorigenesis while suppressing apoptosis. Mechanistically, STAT3 activates CCDC66 transcription to increase circCCDC66 expression, and circCCDC66 promotes NSCLC progression through the miR-33a-5p/KPNA4 ceRNA axis."	0.8005
32159361	American journal of physiology. Cell physiology	2020	Exosomes derived from mmu_circ_0000250-modified adipose-derived mesenchymal stem cells promote wound healing in diabetic mice by inducing miR-128-3p/SIRT1-mediated autophagy.	mmu_circ_0000250		mmu_circ_Rtn4	Rtn4	Diabetic foot ulcer / DFU	MONDO:0005015	diabetes mellitus	down-regulated	RT-qPCR; RNA-seq	"mmu_circ_0000250 was reported to be abnormally lowered in diabetic mice and, when enriched in ADSC-derived exosomes, enhanced repair of diabetic full-thickness wounds. Mechanistically, exosomal mmu_circ_0000250 adsorbed miR-128-3p to increase SIRT1 expression, promoting autophagy, angiogenesis and EPC functional recovery while reducing apoptosis."	0.6544
32162171	Journal of cardiovascular translational research	2021	CircMACF1 Attenuates Acute Myocardial Infarction Through miR-500b-5p-EMP1 Axis.		CircMACF1	mmu_circ_MACF1	MACF1	acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	down-regulated	RT-qPCR	"CircMACF1 is downregulated in mouse myocardial infarction tissues and hypoxia-treated primary mouse cardiomyocytes. Functionally, circMACF1 overexpression protects against AMI-related myocardial injury by inhibiting cardiomyocyte apoptosis and improving cardiac function. Mechanistically, circMACF1 acts as a sponge for miR-500b-5p to upregulate EMP1, forming a circMACF1/miR-500b-5p/EMP1 regulatory axis."	0.5607
32169278	Biochemical and biophysical research communications	2020	"A novel circular RNA, circ-ATAD1, contributes to gastric cancer cell progression by targeting miR-140-3p/YY1/PCIF1 signaling axis."		hsa_circRNA_100641 / circ-ATAD1	hsa_circ_ATAD1	ATAD1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"Circ-ATAD1 is upregulated in gastric cancer tissues and cell lines and high expression predicts unfavorable prognosis. Functionally, it promotes GC cell proliferation, migration and invasion while inhibiting apoptosis. Mechanistically, circ-ATAD1 acts as a cytoplasmic ceRNA that sponges miR-140-3p to increase YY1, which activates PCIF1 transcription."	0.8607
32169757	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2020	CircPIP5K1A activates KRT80 and PI3K/AKT pathway to promote gastric cancer development through sponging miR-671-5p.	hsa_circ_0014130	circPIP5K1A	hsa_circ_PIP5K1A	PIP5K1A	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circPIP5K1A is up-regulated in gastric cancer tissues and cells and acts as an oncogenic circRNA. It promotes proliferation, invasion, migration, EMT and in vivo tumor growth by sponging miR-671-5p, increasing KRT80 expression and activating the PI3K/AKT pathway. The study suggests the circPIP5K1A/miR-671-5p/KRT80 axis may be a therapeutic target in GC."	0.7581
32170433	Biotechnology letters	2020	CircAKT3 inhibits glycolysis balance in lung cancer cells by regulating miR-516b-5p/STAT3 to inhibit cisplatin sensitivity.		Circular RNA AKT3 / CircAKT3	hsa_circ_AKT3	AKT3	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circAKT3 is up-regulated in lung cancer tissues and cell lines. It promotes cisplatin resistance and glycolysis, at least partly through regulation of the miR-516b-5p/STAT3 axis and HIF-1a-dependent glycolysis; circAKT3 knockdown increases cisplatin sensitivity and suppresses tumor growth in vivo."	0.6479
32189040	Calcified tissue international	2020	HNGF6A Inhibits Oxidative Stress-Induced MC3T3-E1 Cell Apoptosis and Osteoblast Phenotype Inhibition by Targeting Circ_0001843/miR-214 Pathway.		Circ_0001843 / Circ_X			osteoporosis / OP	MONDO:0005298	osteoporosis	up-regulated	RT-qPCR	"Circ_0001843 is up-regulated in H2O2-induced oxidative stress injury in MC3T3-E1 osteoblasts and acts as a negative regulator of HNGF6A-mediated cytoprotection and osteogenesis. Mechanistically, Circ_0001843 sponges miR-214 and is linked to TAFA5 regulation and p38/JNK phosphorylation, thereby influencing apoptosis, proliferation, and osteoblast phenotype."	0.5607
32192774	Biochemical and biophysical research communications	2020	Circ0004390 promotes cell proliferation through sponging miR-198 in ovarian cancer.		Circ0004390 / chr1_84866138_84865385	hsa_circ_LPAR3	LPAR3	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; RNA-seq	"Circ0004390 is an LPAR3-derived cytoplasmic circRNA that is upregulated in ovarian cancer tissues. It promotes ovarian cancer cell proliferation by sponging miR-198 and regulating MET expression, and high Circ0004390 expression is associated with shorter overall survival."	0.8381
32192854	Journal of pharmacological sciences	2020	Hsa_circ_0008225 inhibits tumorigenesis of glioma via sponging miR-890 and promoting ZMYND11 expression.	hsa_circ_0008225		hsa_circ_ZMYND11	ZMYND11	glioma	MONDO:0021042	glioma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0008225 is down-regulated in glioma and low expression is associated with poor overall survival. Functionally, hsa_circ_0008225 acts as a tumor suppressor by inhibiting glioma cell proliferation, migration, invasion and xenograft tumor growth while promoting apoptosis. Mechanistically, it sponges miR-890 to promote ZMYND11 expression and inactivate NF-kB p65 signaling, suggesting prognostic and therapeutic relevance."	0.6837
32193602	Archives of gynecology and obstetrics	2020	Circular RNA expression profiling in the fetal side of placenta from maternal polycystic ovary syndrome and circ_0023942 inhibits the proliferation of human ovarian granulosa cell.	hsa_circ_0023942	circ_0023942	hsa_circ_PICALM	PICALM	polycystic ovary syndrome / PCOS	MONDO:0008487	polycystic ovary syndrome	down-regulated	RT-qPCR; Microarray	"circ_0023942 was down-regulated in fetal-side placental tissues from maternal PCOS. Functional assays showed that circ_0023942 overexpression inhibited proliferation of human ovarian granulosa cell lines KGN and COV434, possibly through suppression of CDK4, with predicted involvement of a miRNA-mRNA network and MAPK-related pathways."	0.6676
32193602	Archives of gynecology and obstetrics	2020	Circular RNA expression profiling in the fetal side of placenta from maternal polycystic ovary syndrome and circ_0023942 inhibits the proliferation of human ovarian granulosa cell.	hsa_circ_0002151	circ_0002151			polycystic ovary syndrome / PCOS	MONDO:0008487	polycystic ovary syndrome	dysregulated	RT-qPCR; Microarray	"circ_0002151 was one of six differentially expressed circRNAs selected from the placental circRNA microarray for RT-qPCR validation, and its expression pattern was consistent with the microarray data in fetal-side placental tissues from maternal PCOS. No functional mechanism was reported for this circRNA."	0.4773
32193602	Archives of gynecology and obstetrics	2020	Circular RNA expression profiling in the fetal side of placenta from maternal polycystic ovary syndrome and circ_0023942 inhibits the proliferation of human ovarian granulosa cell.	hsa_circ_0001274	circ_0001274			polycystic ovary syndrome / PCOS	MONDO:0008487	polycystic ovary syndrome	dysregulated	RT-qPCR; Microarray	"circ_0001274 was one of six differentially expressed circRNAs selected from the placental circRNA microarray for RT-qPCR validation, and its expression pattern was consistent with the microarray data in fetal-side placental tissues from maternal PCOS. No functional mechanism was reported for this circRNA."	0.4773
32193602	Archives of gynecology and obstetrics	2020	Circular RNA expression profiling in the fetal side of placenta from maternal polycystic ovary syndrome and circ_0023942 inhibits the proliferation of human ovarian granulosa cell.	hsa_circ_0008514	circ_0008514			polycystic ovary syndrome / PCOS	MONDO:0008487	polycystic ovary syndrome	dysregulated	RT-qPCR; Microarray	"circ_0008514 was one of six differentially expressed circRNAs selected from the placental circRNA microarray for RT-qPCR validation, and its expression pattern was consistent with the microarray data in fetal-side placental tissues from maternal PCOS. No functional mechanism was reported for this circRNA."	0.4773
32194140	Cancer letters	2020	Exosome-mediated transfer of circRNA CircNFIX enhances temozolomide resistance in glioma.		circRNA nuclear factor I X	hsa_circ_NFIX	nuclear factor I X	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"CircNFIX is up-regulated in serum exosomes from TMZ-resistant glioma patients and in TMZ-resistant glioma cells, and high exosomal CircNFIX is associated with poor prognosis. Exosome-mediated transfer of CircNFIX promotes TMZ resistance by enhancing migration, invasion, ABCG2 expression, and tumor growth while suppressing apoptosis. Mechanistically, CircNFIX acts as a ceRNA by binding miR-132, and CircNFIX knockdown increases TMZ sensitivity in vitro and in vivo."	0.7888
32194149	Molecular and cellular probes	2020	Circular RNA MTO1 suppresses tumorigenesis of gastric carcinoma by sponging miR-3200-5p and targeting PEBP1.		Circular RNA MTO1 / circMTO1	hsa_circ_MTO1	MTO1	gastric carcinoma	MONDO:0004950	gastric carcinoma	down-regulated	RT-qPCR	"circMTO1 is down-regulated in gastric carcinoma tissues and cell lines. It functions as a tumor-suppressive circRNA by sponging miR-3200-5p and regulating PEBP1, thereby inhibiting GC cell proliferation, migration, invasion and EMT. The study suggests circMTO1 as a potential therapeutic target for GC."	0.7283
32199215	Ecotoxicology and environmental safety	2020	circ_0000638 inhibits neodymium oxide-induced bronchial epithelial cell inflammation through the miR-498-5p/NF-kappaB axis.	hsa_circ_0000638	circRNA_0000638 / circ_0000638			lung injury	MONDO:0015796	acute lung injury	down-regulated	RT-qPCR; Microarray	"circ_0000638 is downregulated in neodymium oxide-treated human bronchial epithelial 16HBE cells. Functionally, it suppresses inflammatory IL-8 and IL-1beta expression by acting as a miR-498-5p sponge, increasing NKRF, and inhibiting NF-kappaB activation. The study suggests circ_0000638 may have potential as an early biomarker or therapeutic clue for rare-earth element-induced lung injury."	0.6793
32199934	Cellular signalling	2020	Comprehensive characterization of circular RNAs in osteosarcoma cell lines.	hsa_circ_0000591				osteosarcoma / OS	MONDO:0009807	osteosarcoma	dysregulated	RNA-seq	hsa_circ_0000591 was identified from RNA-seq data as a metastasis-related circRNA in osteosarcoma cell lines and included in a predicted ceRNA network. Its proposed role is computational and involves potential miRNA-mRNA regulatory interactions in OS metastasis.	0.1768
32199934	Cellular signalling	2020	Comprehensive characterization of circular RNAs in osteosarcoma cell lines.	hsa_circ_0021570				osteosarcoma / OS	MONDO:0009807	osteosarcoma	dysregulated	RNA-seq	"hsa_circ_0021570 was identified as a differentially expressed, metastasis-related circRNA in osteosarcoma cell lines and incorporated into a predicted ceRNA network. Bioinformatic enrichment linked it to cancer-related pathways, including mTOR signaling and EGFR tyrosine kinase inhibitor resistance."	0.1768
32199934	Cellular signalling	2020	Comprehensive characterization of circular RNAs in osteosarcoma cell lines.	hsa_circ_0002618		hsa_circ_MGA	MGA	osteosarcoma / OS	MONDO:0009807	osteosarcoma	dysregulated	RNA-seq	"hsa_circ_0002618 was identified as a metastasis-related circRNA in osteosarcoma cell lines and included in a predicted ceRNA network. Bioinformatic analyses associated it with cancer-related pathways, suggesting a possible role in OS metastasis."	0.1768
32199934	Cellular signalling	2020	Comprehensive characterization of circular RNAs in osteosarcoma cell lines.	hsa_circ_0002925				osteosarcoma / OS	MONDO:0009807	osteosarcoma	dysregulated	RNA-seq	hsa_circ_0002925 was identified as a differentially expressed metastasis-related circRNA in osteosarcoma cell lines and included in a predicted ceRNA network. The study suggests it may participate in OS metastasis through miRNA-mRNA regulatory interactions.	0.1768
32199934	Cellular signalling	2020	Comprehensive characterization of circular RNAs in osteosarcoma cell lines.	hsa_circ_0085360		hsa_circ_TRPS1	TRPS1	osteosarcoma / OS	MONDO:0009807	osteosarcoma	dysregulated	RNA-seq	"hsa_circ_0085360 was identified as a metastasis-related osteosarcoma circRNA in a predicted ceRNA network. It showed the strongest correlation with its host gene TRPS1, and its downstream target FGFR3 and TRPS1 were associated with event-free and overall survival, suggesting potential prognostic relevance."	0.1768
32208321	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2020	"A novel circular RNA (hsa_circRNA_102336), a plausible biomarker, promotes the tumorigenesis by sponging miR-515-5p in human bladder cancer."		hsa_circRNA_102336	hsa_circ_TAF4B	TAF4B	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"Circ_102336 is an up-regulated TAF4B-derived circRNA in human bladder cancer tissues and cell lines, and high expression is associated with worse overall survival. Functionally, it promotes BC cell proliferation and CDDP chemo-resistance. Mechanistically, circ_102336 sponges and negatively regulates miR-515-5p, with KEGG/network analyses implicating apoptosis and ABC transporter-related pathways."	0.7842
32209259	Biochemical and biophysical research communications	2020	CircEHMT1 inhibits metastatic potential of breast cancer cells by modulating miR-1233-3p/KLF4/MMP2 axis.		circEHMT1	hsa_circ_EHMT1	EHMT1	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	"circEHMT1 is downregulated in breast cancer tissues and acts as a tumor suppressor. It inhibits migration, invasion, and lung metastasis partly by sponging miR-1233-3p and relieving repression of KLF4, thereby reducing MMP2-related metastatic potential."	0.7968
32217695	Cancer research	2020	CircFOXK2 Promotes Growth and Metastasis of Pancreatic Ductal Adenocarcinoma by Complexing with RNA-Binding Proteins and Sponging MiR-942.		circFOXK2 / circFOKX2	hsa_circ_FOXK2	FOXK2	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"circFOXK2 is significantly up-regulated in PDAC cells and primary tumors. It promotes PDAC cell growth, migration, invasion, tumor growth and liver metastasis by sponging miR-942 to increase ANK1, GDNF and PAX6 expression, and by interacting with YBX1/hnRNPK to promote NUF2 and PDXK expression. The study suggests circFOXK2 may serve as a diagnostic marker and therapeutic target for PDAC."	0.8757
32220601	Gene	2020	Loss of hsa_circ_0118530 inhibits human granulosa-like tumor cell line KGN cell injury by sponging miR-136.	hsa_circ_0118530				Polycystic ovary syndrome / PCOS	MONDO:0008487	polycystic ovary syndrome	up-regulated	RT-qPCR	"hsa_circ_0118530 is up-regulated in granulosa cells from PCOS patients and in granulosa cell lines. In KGN cells, hsa_circ_0118530 knockdown suppresses proliferation, migration, EMT, oxidative stress and inflammatory cytokine release while inducing apoptosis. Mechanistically, the study supports that hsa_circ_0118530 promotes PCOS-related cellular injury by sponging miR-136."	0.7052
32226705	3 Biotech	2020	Dexmedetomidine alleviates postoperative cognitive dysfunction through circular RNA in aged rats.		circ-Shank3	rno_circ_Shank3	Shank3	postoperative cognitive dysfunction / POCD	MONDO:0002602	central nervous system disorder	up-regulated	RT-qPCR; RNA-seq	circ-Shank3 was significantly higher in POCD rat hippocampal tissue than in Dex-treated POCD rats and was validated by qRT-PCR. The study proposes that circ-Shank3 may participate in Dex-mediated improvement of POCD through a predicted circRNA-miRNA-mRNA network and regulation of P53 and NF-kappaB signaling pathways involving targets such as Fkbp5 and Lrrc32.	0.5202
32226705	3 Biotech	2020	Dexmedetomidine alleviates postoperative cognitive dysfunction through circular RNA in aged rats.		circ-Cdc42bpa	rno_circ_Cdc42bpa	Cdc42bpa	postoperative cognitive dysfunction / POCD	MONDO:0002602	central nervous system disorder	up-regulated	RT-qPCR; RNA-seq	circ-Cdc42bpa was identified by circRNA sequencing and validated by qRT-PCR as significantly higher in POCD rat hippocampal tissue than in Dex-treated POCD rat hippocampal tissue. The paper did not define a circ-Cdc42bpa-specific molecular mechanism or functional axis.	0.4375
32226705	3 Biotech	2020	Dexmedetomidine alleviates postoperative cognitive dysfunction through circular RNA in aged rats.		circchrx-24658 / circ-chrx-24658			postoperative cognitive dysfunction / POCD	MONDO:0002602	central nervous system disorder	up-regulated	RT-qPCR; RNA-seq	circ-chrx-24658 was identified by circRNA sequencing and validated by qRT-PCR as significantly higher in POCD rat hippocampal tissue than in Dex-treated POCD rat hippocampal tissue. The paper did not define a circ-chrx-24658-specific molecular mechanism or functional axis.	0.4375
32229309	Molecular therapy : the journal of the American Society of Gene Therapy	2020	The Circular RNA circSKA3 Binds Integrin beta1 to Induce Invadopodium Formation Enhancing Breast Cancer Invasion.	hsa_circ_0000467 	circSKA3 / circ-SKA3	hsa_circ_SKA3	SKA3	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circSKA3 is up-regulated in human breast cancer cells and tissues and is positively correlated with disease stage. It promotes breast cancer migration, invasion, proliferation, tumor progression, and invadopodium formation by binding and bridging Itgb1/integrin beta1 and Tks5 at the membrane/invadopodia. In xenograft models, circSKA3 overexpression increases tumor growth and invasion, whereas circSKA3 silencing reduces invadopodia and improves mouse survival."	0.8395
32233622	Annals of palliative medicine	2020	Quietness Circ 0000962 promoted nerve cell inflammation through PIK3CA/Akt/NF-kappaB signaling by miR-302b-3p in spinal cord injury.	rno_circ_0000962	Circ 0000962			spinal cord injury / SCI	MONDO:0043797	spinal cord injury	down-regulated	RT-qPCR; Microarray	"Circ 0000962 is decreased in rat spinal cord injury and an in vitro SCI model. Functional experiments indicate that restoring Circ 0000962 reduces inflammatory cytokine production, likely through regulation of miR-302b-3p and the PIK3CA/PI3K/Akt/NF-kappaB signaling pathway."	0.5679
32234499	Archives of biochemistry and biophysics	2020	"Hsa_circ_0011290 regulates proliferation, apoptosis and glycolytic phenotype in papillary thyroid cancer via miR-1252/ FSTL1 signal pathway."	hsa_circ_0011290	circ_0011290			papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"hsa_circ_0011290 is up-regulated in papillary thyroid cancer tissues and cell lines, and high expression is associated with advanced stage and poor prognosis. Functionally, it promotes PTC cell viability, proliferation and glycolytic phenotype while suppressing apoptosis. Mechanistically, hsa_circ_0011290 sponges miR-1252 to increase FSTL1 expression, forming an oncogenic hsa_circ_0011290-miR-1252-FSTL1 axis."	0.7537
32240746	Cellular signalling	2020	circ_ARF3 regulates the pathogenesis of osteosarcoma by sponging miR-1299 to maintain CDK6 expression.		circ_ARF3	hsa_circ_ARF3	ARF3	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ_ARF3 is up-regulated in osteosarcoma cell lines and tumor tissues. It promotes osteosarcoma cell proliferation, colony formation, G1/S cell-cycle transition, and xenograft tumor growth by sponging miR-1299 and maintaining CDK6 expression. The study suggests circ_ARF3 as a potential biomarker or therapeutic target for osteosarcoma."	0.8107
32240747	Cellular signalling	2020	Circ_0001178 regulates miR-382/VEGFA axis to facilitate hepatocellular carcinoma progression.	hsa_circ_0001178	circ_0001178			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0001178 is up-regulated in HCC tissues and cell lines and functions as an oncogenic circRNA. Its knockdown suppresses HCC proliferation, migration, invasion and xenograft tumor growth while promoting apoptosis and G1 arrest. Mechanistically, circ_0001178 negatively regulates miR-382 and increases VEGFA expression through the circ_0001178/miR-382/VEGFA axis."	0.7756
32247616	Biochemical and biophysical research communications	2020	A circRNA derived from linear HIPK3 relieves the neuronal cell apoptosis in spinal cord injury via ceRNA pattern.		Circular RNA homeodomain interacting protein kinase 3	hsa_circ_HIPK3	HIPK3	spinal cord injury / SCI	MONDO:0043797	spinal cord injury	down-regulated	RT-qPCR	"This study found that circ-HIPK3 is down-regulated in SCI rat models and CoCl2-induced neuronal cell injury models. Functionally, circ-HIPK3 suppresses neuronal apoptosis and exerts a protective effect in SCI. Mechanistically, circ-HIPK3 acts as a ceRNA for miR-558 to up-regulate DPYSL5, forming a circ-HIPK3/miR-558/DPYSL5 axis."	0.8152
32247616	Biochemical and biophysical research communications	2020	A circRNA derived from linear HIPK3 relieves the neuronal cell apoptosis in spinal cord injury via ceRNA pattern.		Circular RNA homeodomain interacting protein kinase 3	rno_circ_HIPK3	HIPK3	spinal cord injury / SCI	MONDO:0043797	spinal cord injury	down-regulated	RT-qPCR	"This study found that circ-HIPK3 is down-regulated in SCI rat models and CoCl2-induced neuronal cell injury models. Functionally, circ-HIPK3 suppresses neuronal apoptosis and exerts a protective effect in SCI. Mechanistically, circ-HIPK3 acts as a ceRNA for miR-558 to up-regulate DPYSL5, forming a circ-HIPK3/miR-558/DPYSL5 axis."	0.8152
32250392	"Rheumatology (Oxford, England)"	2020	Circular RNA sequencing indicates circ-IQGAP2 and circ-ZC3H6 as noninvasive biomarkers of primary Sj_gren's syndrome.	hsa_circ_0129656	Circ-IQGAP2	hsa_circ_IQGAP2	IQGAP2	primary Sj_gren's syndrome / pSS	MONDO:0019347	peeling skin syndrome	up-regulated	RT-qPCR; RNA-seq	"circ-IQGAP2 is up-regulated in minor salivary glands and plasma exosomes from pSS patients. Its expression correlates with serum IgG level and MSG focus score, and it contributes diagnostic value when combined with clinical features. Mechanistically, the study predicts a circ-IQGAP2-miRNA-mRNA network enriched in immune cell proliferation/activation and IFN-related processes."	0.6556
32250392	"Rheumatology (Oxford, England)"	2020	Circular RNA sequencing indicates circ-IQGAP2 and circ-ZC3H6 as noninvasive biomarkers of primary Sj_gren's syndrome.	hsa_circ_0001062	Circ-ZC3H6	hsa_circ_ZC3H6	ZC3H6	primary Sj_gren's syndrome / pSS	MONDO:0019347	peeling skin syndrome	up-regulated	RT-qPCR; RNA-seq	"circ-ZC3H6 is up-regulated in minor salivary glands and plasma exosomes from pSS patients. Its expression correlates with serum IgG level and MSG focus score and showed strong diagnostic contribution in random forest models. Mechanistically, the study predicts a circ-ZC3H6-miRNA-mRNA network enriched in immune cell proliferation/activation and IFN-related processes."	0.6556
32251633	Life sciences	2020	Berberine attenuates Abeta42-induced neuronal damage through regulating circHDAC9/miR-142-5p axis in human neuronal cells.	hsa_circ_0003594	circRNA histone deacetylase 9 / circHDAC9	hsa_circ_HDAC9	HDAC9	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR	"This study found that circHDAC9 is down-regulated in Abeta42-treated human neuronal cells and is up-regulated by berberine treatment. circHDAC9 is mainly cytoplasmic and alleviates Abeta42-induced neuronal damage by sponging miR-142-5p, thereby promoting cell viability while reducing apoptosis and inflammatory cytokine production."	0.7404
32253030	Biochemical and biophysical research communications	2020	CircRNACCDC66 regulates cisplatin resistance in gastric cancer via the miR-618/BCL2 axis.	hsa_circ_0001313	circCCDC66	hsa_circ_CCDC66	CCDC66	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"CircCCDC66 is up-regulated in CDDP-resistant gastric cancer tissues and cell lines. It promotes cisplatin resistance by sponging miR-618 and relieving repression of BCL2, thereby inhibiting apoptosis. High circCCDC66 expression is associated with CDDP resistance and worse disease-free survival, suggesting biomarker and therapeutic-target potential."	0.8734
32259630	Gene	2020	circRNA_0084043 contributes to the progression of diabetic retinopathy via sponging miR-140-3p and inducing TGFA gene expression in retinal pigment epithelial cells.	hsa_circ_0084043	circRNA_0084043			Diabetic retinopathy / DR	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR	"circRNA_0084043 is up-regulated in high glucose-treated ARPE-19 cells as an in vitro diabetic retinopathy model. Knockdown of circRNA_0084043 protects against HG-induced injury by improving cell survival and reducing apoptosis, oxidative stress and inflammation. Mechanistically, circRNA_0084043 acts through a miR-140-3p/TGFA regulatory axis."	0.5607
32259632	Gene	2020	hsa_circ_0041795 contributes to human retinal pigment epithelial cells (ARPE 19) injury induced by high glucose via sponging miR-646 and activating VEGFC.	hsa_circ_0041795				diabetic retinopathy / DR	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR	"hsa_circ_0041795 is up-regulated in high glucose-treated ARPE-19 cells, a cellular model related to diabetic retinopathy. Its knockdown protects ARPE-19 cells by promoting proliferation and reducing apoptosis and inflammatory cytokine expression. Mechanistically, hsa_circ_0041795 sponges miR-646 and regulates VEGFC, suggesting therapeutic potential for DR."	0.5607
32266733	Cell biochemistry and function	2020	"Circular RNA has_circ_0000527 participates in proliferation, invasion and migration of retinoblastoma cells via miR-646/BCL-2 axis."	hsa_circ_0000527	circ_0000527			Retinoblastoma / RB	MONDO:0008380	retinoblastoma	up-regulated	RT-qPCR	"circ_0000527 is up-regulated in retinoblastoma tissues and cell lines. It promotes RB cell proliferation, viability, migration and invasion while suppressing apoptosis. Mechanistically, circ_0000527 sponges miR-646 to increase BCL-2 expression, and its high expression is associated with more aggressive clinicopathological features."	0.7032
32274658	Human cell	2020	Circular RNA hsa_circ_0002052 promotes osteosarcoma via modulating miR-382/STX6 axis.	hsa_circ_0002052	circ-0002052			osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0002052/circ-0002052 is up-regulated in osteosarcoma tissues and cells and is associated with advanced stage, tumor size, metastasis, and poor survival. Functionally, it promotes OS cell proliferation, migration, and invasion by sponging miR-382, increasing STX6 expression, and activating Wnt/beta-catenin signaling, suggesting prognostic and therapeutic relevance."	0.8244
32275999	Gene	2020	Circ_0000285 promotes podocyte injury through sponging miR-654-3p and activating MAPK6 in diabetic nephropathy.	mmu_circ_0000285	circ_0000285			diabetic nephropathy / DN	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"This study reports that circ_0000285 is up-regulated in streptozotocin-induced DN mouse kidney tissues and high-glucose-treated mouse podocytes. Functionally, circ_0000285 promotes podocyte injury by inhibiting proliferation, inducing apoptosis and cell-cycle arrest, and increasing inflammatory cytokine release. Mechanistically, circ_0000285 sponges miR-654-3p to activate MAPK6, forming a circ_0000285/miR-654-3p/MAPK6 regulatory axis in DN progression."	0.6278
32277518	Journal of cellular biochemistry	2020	Hsa_circ_0031288/hsa-miR-139-3p/Bcl-6 regulatory feedback circuit influences the invasion and migration of cervical cancer HeLa cells.	hsa_circ_0031288		hsa_circ_PABPN1		cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"hsa_circ_0031288 is up-regulated in cervical cancer tissues and HeLa cells. It promotes cervical cancer cell proliferation, invasion, migration, and xenograft tumor growth, likely by sponging hsa-miR-139-3p and thereby relieving inhibition of Bcl-6. The study suggests hsa_circ_0031288 may serve as an early diagnostic marker and therapeutic intervention target in cervical cancer."	0.7032
32297303	"Cellular oncology (Dordrecht, Netherlands)"	2020	CircRNA BIRC6 promotes non-small cell lung cancer cell progression by sponging microRNA-145.			hsa_circ_BIRC6	BIRC6	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"This study found that human circBIRC6 is upregulated in NSCLC tissues and cells. Functionally, circBIRC6 promotes NSCLC cell growth, proliferation, migration and invasion, while circBIRC6 knockdown suppresses xenograft growth. Mechanistically, circBIRC6 likely sponges miR-145 and thereby modulates miR-145 targets including FSCN1 and S6K1."	0.6287
32302508	Cancer biotherapy & radiopharmaceuticals	2021	"hsa_circ_0072387 Suppresses Proliferation, Metastasis, and Glycolysis of Oral Squamous Cell Carcinoma Cells by Downregulating miR-503-5p."	hsa_circ_0072387				oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR	"hsa_circ_0072387 is downregulated in OSCC tissues and cell lines, and higher expression is associated with better patient survival. Functionally, hsa_circ_0072387 suppresses OSCC cell proliferation, migration, invasion, EMT, metastasis, and glycolysis. Mechanistically, it directly targets and downregulates miR-503-5p, and miR-503-5p overexpression partially reverses the tumor-suppressive effects of hsa_circ_0072387."	0.7507
32305357	"Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases"	2020	Integrated analyses reveal hsa_circ_0028883 as a diagnostic biomarker in active tuberculosis.	hsa_circ_0028883		hsa_circ_DYNLL1	DYNLL1	active tuberculosis	MONDO:0100481	active tuberculosis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0028883 was identified from GEO circRNA expression datasets and validated by qRT-PCR as significantly upregulated in PBMCs from active TB patients. Bioinformatics analyses suggested a hsa_circ_0028883/hsa-miR-409-5p/mRNA ceRNA regulatory module, and ROC analysis supported its potential diagnostic value for active tuberculosis."	0.5047
32305633	Gene	2020	CircRNA_100876 sponges miR-136 to promote proliferation and metastasis of gastric cancer by upregulating MIEN1 expression.		circRNA_100876			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circRNA_100876 is up-regulated in gastric cancer tissues and acts as an oncogenic circRNA. Functionally, it promotes GC cell proliferation, migration, invasion and metastasis. Mechanistically, circRNA_100876 sponges miR-136 to upregulate MIEN1 expression, forming a circRNA_100876/miR-136/MIEN1 regulatory axis."	0.6479
32307741	Cell biochemistry and function	2020	CircRNA-0077930 from hyperglycaemia-stimulated vascular endothelial cell exosomes regulates senescence in vascular smooth muscle cells.		circRNA-0077930			diabetes-related vasculopathy	MONDO:0000960	diabetic peripheral angiopathy	up-regulated	RT-qPCR; Microarray	"This study identified circRNA-0077930 as an up-regulated exosomal circRNA in high-glucose-stimulated HUVEC exosomes. Exosomal circRNA-0077930 promotes VSMC senescence through the circRNA-0077930/miR-622/Kras ceRNA network, increasing Kras and senescence-associated proteins p21, p53 and p16; depletion of circRNA-0077930 abolishes the pro-senescent effect of HG-HUVEC exosomes."	0.683
32319024	Cell stress & chaperones	2020	Inhibition of hsa_circ_0002570 suppresses high-glucose-induced angiogenesis and inflammation in retinal microvascular endothelial cells through miR-1243/angiomotin axis.	hsa_circ_0002570				Diabetic retinopathy / DR	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR	"hsa_circ_0002570 is up-regulated in diabetic retinopathy patient membranes and high-glucose-induced hRMECs. It promotes endothelial proliferation, migration, tube formation/angiogenesis, VEGF secretion, and inflammatory cytokine release by acting as a ceRNA for miR-1243 and upregulating angiomotin/AMOT. The study proposes circ_0002570 as a potential diagnostic and therapeutic target for DR."	0.7045
32321304	"Experimental biology and medicine (Maywood, N.J.)"	2020	Circular RNA circ-CDYL sponges miR-1180 to elevate yes-associated protein in multiple myeloma.		circ-CDYL	hsa_circ_CDYL	CDYL	multiple myeloma / MM	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR	"circ-CDYL is up-regulated in multiple myeloma tissues and plasma and is associated with advanced stage, diagnostic potential, and poor survival. It promotes MM cell growth and in vivo tumor progression by acting as a cytoplasmic sponge for miR-1180, thereby increasing YAP expression through the circ-CDYL/miR-1180/YAP axis."	0.8521
32321346	Lupus	2020	Hsa_circ_0012919 regulates expression of MDA5 by miR-125a-3p in CD4+ T cells of systemic lupus erythematous.	hsa_circ_0012919				systemic lupus erythematosus / SLE	MONDO:0007915	systemic lupus erythematosus	up-regulated	RT-qPCR	"This study shows that hsa_circ_0012919 is up-regulated in CD4+ T cells from SLE patients and is associated with disease-related clinical features. Functional perturbation by siRNA or plasmid indicates that hsa_circ_0012919 regulates MDA5 expression and MDA5 promoter methylation in lupus CD4+ T cells, at least partly through a miR-125a-3p-mediated ceRNA mechanism."	0.4862
32329660	"Cell cycle (Georgetown, Tex.)"	2020	Overexpression of circARF3 mitigates TNF-alpha-induced inflammatory damage by up-regulating miR-125b.	hsa_circ_0026070	circARF3	hsa_circ_ARF3	ARF3	Encephalitis	MONDO:0019956	encephalitis	down-regulated	RT-qPCR	"circARF3 was down-regulated in TNF-alpha-induced SH-SY5Y inflammatory damage. Overexpression of circARF3 protected cells by improving viability, reducing apoptosis, cytokine production and ROS generation, and suppressing JNK and NF-kappaB pathway activation through positive regulation of miR-125b."	0.5607
32335360	Neurobiology of aging	2020	Assessing circular RNAs in Alzheimer's disease and frontotemporal lobar degeneration.		circHOMER1	hsa_circ_HOMER1	HOMER1	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR	"circHOMER1 was significantly down-regulated in sporadic and autosomal dominant AD and was also decreased in FTLD-Tau. Its expression negatively correlated with Braak scores, suggesting association with neurodegenerative pathology severity."	0.429
32335360	Neurobiology of aging	2020	Assessing circular RNAs in Alzheimer's disease and frontotemporal lobar degeneration.		circKCNN2	hsa_circ_KCNN2	KCNN2	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR	circKCNN2 was significantly down-regulated in sporadic and autosomal dominant AD and was also reduced in FTLD-TDP43. Its negative correlation with Braak scores links its expression to neuropathological severity.	0.429
32335360	Neurobiology of aging	2020	Assessing circular RNAs in Alzheimer's disease and frontotemporal lobar degeneration.		circDOCK1	hsa_circ_DOCK1	DOCK1	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR	"circDOCK1 was up-regulated in both sporadic and autosomal dominant AD compared with controls. Its expression showed a positive relationship with Braak scores, indicating an association with AD neuropathological staging."	0.429
32335360	Neurobiology of aging	2020	Assessing circular RNAs in Alzheimer's disease and frontotemporal lobar degeneration.		circFMN1	hsa_circ_FMN1	FMN1	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR	"circFMN1 was significantly down-regulated in autosomal dominant AD compared with controls. It also showed a negative relationship with Braak scores, although this correlation was reported as a trend rather than statistically significant."	0.429
32337768	Journal of leukocyte biology	2020	The regulated profile of noncoding RNAs associated with inflammation by tanshinone IIA on atherosclerosis.		circ-Cd84 (SLAMF5) / circ-Cd84	mmu_circ_Cd84	Cd84 (SLAMF5)	Atherosclerosis / AS	MONDO:0005311	atherosclerosis	dysregulated	RT-qPCR; RNA-seq	"In this mouse atherosclerosis study, circ-Cd84 was significantly down-regulated by tanshinone IIA and mainly localized in the cytoplasm. It functions as a ceRNA sponge for miR-30c in the circ-Cd84/miR-30c/Tlr2 axis, potentially promoting inflammatory signaling in AS plaques."	0.6111
32337768	Journal of leukocyte biology	2020	The regulated profile of noncoding RNAs associated with inflammation by tanshinone IIA on atherosclerosis.		circ-Wdr91	mmu_circ_Wdr91	Wdr91	Atherosclerosis / AS	MONDO:0005311	atherosclerosis	dysregulated	RT-qPCR; RNA-seq	"In this mouse atherosclerosis study, circ-Wdr91 was significantly down-regulated by tanshinone IIA and mainly localized in the cytoplasm. It functions as a ceRNA sponge for miR-378a-5p in the circ-Wdr91/miR-378a-5p/Msr1 axis, potentially promoting inflammatory responses in AS plaques."	0.6111
32337768	Journal of leukocyte biology	2020	The regulated profile of noncoding RNAs associated with inflammation by tanshinone IIA on atherosclerosis.		circ-Tns3	mmu_circ_Tns3	Tns3	Atherosclerosis / AS	MONDO:0005311	atherosclerosis	dysregulated	RT-qPCR; RNA-seq	"In this mouse atherosclerosis study, circ-Tns3 was significantly down-regulated by tanshinone IIA and mainly localized in the cytoplasm. It functions as a ceRNA sponge for let-7d-5p in the circ-Tns3/let-7d-5p/Ctsl axis, potentially promoting inflammatory responses in AS plaques."	0.6111
32343603	Cancer biotherapy & radiopharmaceuticals	2021	Knockdown of circAPLP2 Inhibits Progression of Colorectal Cancer by Regulating miR-485-5p/FOXK1 Axis.	hsa_circ_0000372	circRNA amyloid precursor-like protein 2	hsa_circ_APLP2	APLP2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circAPLP2 is up-regulated in colorectal cancer tissues and cell lines and is associated with more advanced pathological stage. Functionally, circAPLP2 promotes CRC proliferation, migration, invasion, EMT, glycolysis and xenograft tumor growth while suppressing apoptosis. Mechanistically, circAPLP2 acts as a ceRNA for miR-485-5p to increase FOXK1 expression, forming the circAPLP2/miR-485-5p/FOXK1 axis."	0.7591
32360844	Gene	2020	Upregulation of circ-0000745 in acute lymphoblastic leukemia enhanced cell proliferation by activating ERK pathway.		circ-0000745			acute lymphoblastic leukemia / ALL	MONDO:0004967	acute lymphoblastic leukemia	up-regulated	RT-qPCR	"circ-0000745 is up-regulated in human leukemia cell lines Kasumi-1 and KG-1 compared with primary T lymphocytes. Functional experiments indicate that circ-0000745 promotes leukemia cell proliferation and colony formation while inhibiting apoptosis, at least partly through activation of ERK signaling."	0.5679
32365279	"Anatomical record (Hoboken, N.J. : 2007)"	2021	CircFBXW7 alleviates glioma progression through regulating miR-23a-3p/PTEN axis.		circFBXW7	hsa_circ_FBXW7	FBXW7	glioma	MONDO:0021042	glioma	down-regulated	RT-qPCR	"circFBXW7 is downregulated in glioma tissues and cell lines and functions as a tumor-suppressive circRNA. Its overexpression inhibits glioma cell proliferation, migration, invasion, tumor growth and metastasis by sponging miR-23a-3p and increasing PTEN expression. Clinically, lower circFBXW7 expression is associated with larger tumor size, higher WHO grade and shorter overall survival."	0.7779
32367651	The journal of gene medicine	2020	"Hsa_circ_0102272 serves as a prognostic biomarker and regulates proliferation, migration and apoptosis in thyroid cancer."	hsa_circ_0102272		hsa_circ_RTN1	RTN1	thyroid cancer / TC	MONDO:0002108	thyroid cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0102272 is up-regulated in thyroid cancer tissues and cell lines and appears to function as an oncogenic circRNA. Silencing hsa_circ_0102272 suppresses thyroid cancer cell proliferation, migration and invasion while promoting apoptosis. Clinically, high hsa_circ_0102272 expression is associated with aggressive clinicopathological features and poor survival, supporting its value as a prognostic biomarker."	0.7784
32369647	Journal of pineal research	2020	Melatonin ameliorates aortic valve calcification via the regulation of circular RNA CircRIC3/miR-204-5p/DPP4 signaling in valvular interstitial cells.	hsa_circ_0021086	CircRIC3	hsa_circ_RIC3	RIC3	Calcific aortic valve disease / CAVD	MONDO:0005463	aortic valve calcification	up-regulated	RT-qPCR; Microarray	"CircRIC3 is an upregulated procalcification circRNA in calcific aortic valve disease. It is mainly cytoplasmic and acts as a sponge for miR-204-5p, thereby increasing DPP4 expression and promoting hVIC osteogenic differentiation and calcium deposition. Melatonin reduces CircRIC3 levels and inhibits the CircRIC3/miR-204-5p/DPP4 axis, contributing to reduced aortic valve calcification."	0.8547
32369647	Journal of pineal research	2020	Melatonin ameliorates aortic valve calcification via the regulation of circular RNA CircRIC3/miR-204-5p/DPP4 signaling in valvular interstitial cells.	mmu_circ_0013746	CircRIC3	mmu_circ_RIC3	RIC3	Calcific aortic valve disease / CAVD	MONDO:0005463	aortic valve calcification	up-regulated	RT-qPCR; Microarray	"CircRIC3 is an upregulated procalcification circRNA in calcific aortic valve disease. It is mainly cytoplasmic and acts as a sponge for miR-204-5p, thereby increasing DPP4 expression and promoting hVIC osteogenic differentiation and calcium deposition. Melatonin reduces CircRIC3 levels and inhibits the CircRIC3/miR-204-5p/DPP4 axis, contributing to reduced aortic valve calcification."	0.8547
32376451	Gene	2020	Hsa_circ_0017639 expression promotes gastric cancer proliferation and metastasis by sponging miR-224-5p and upregulating USP3.	hsa_circ_0017639	circ-SFMBT2	hsa_circ_SFMBT2	SFMBT2	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"hsa_circ_0017639 is upregulated in gastric cancer cell lines and mainly localized in the cytoplasm. It promotes gastric cancer proliferation, migration and xenograft tumor growth by sponging miR-224-5p and regulating USP3 through the miR-224-5p/USP3 axis, suggesting potential therapeutic relevance."	0.657
32376473	Experimental eye research	2020	Differentially expressed circular RNAs in orbital adipose/connective tissue from patients with thyroid-associated ophthalmopathy.	hsa_circ_0084764	circRNA_14940			thyroid-associated ophthalmopathy / TAO	MONDO:0001509	endocrine exophthalmos	up-regulated	RT-qPCR; RNA-seq	"circRNA_14940/hsa_circ_0084764 was up-regulated in TAO orbital adipose/connective tissue and validated by qRT-PCR. It was correlated with CCND1 and TNXB and was proposed to participate in TAO pathogenesis through Wnt signaling, ECM-receptor interaction, and PI3K-Akt signaling."	0.5135
32376473	Experimental eye research	2020	Differentially expressed circular RNAs in orbital adipose/connective tissue from patients with thyroid-associated ophthalmopathy.		circRNA_14936			thyroid-associated ophthalmopathy / TAO	MONDO:0001509	endocrine exophthalmos	up-regulated	RT-qPCR; RNA-seq	"circRNA_14936 was a novel circRNA up-regulated in TAO orbital adipose/connective tissue and validated by qRT-PCR. It was predicted to interact with hsa-miR-10392-3p and correlated with TNFRSF19, suggesting a possible role in cytokine-cytokine receptor interaction and B-cell-related immune regulation in TAO."	0.5135
32376473	Experimental eye research	2020	Differentially expressed circular RNAs in orbital adipose/connective tissue from patients with thyroid-associated ophthalmopathy.		circRNA_10135			thyroid-associated ophthalmopathy / TAO	MONDO:0001509	endocrine exophthalmos	up-regulated	RNA-seq	"circRNA_10135 was identified by RNA sequencing as an up-regulated circRNA in the TAO co-expression network. It was correlated with PTGFR and proposed to affect TAO adipogenesis via calcium signaling, but it was not reported as qRT-PCR validated."	0.348
32376473	Experimental eye research	2020	Differentially expressed circular RNAs in orbital adipose/connective tissue from patients with thyroid-associated ophthalmopathy.	hsa_circ_0073237	circRNA_12367			thyroid-associated ophthalmopathy / TAO	MONDO:0001509	endocrine exophthalmos	down-regulated	RT-qPCR; RNA-seq	"circRNA_12367/hsa_circ_0073237 was down-regulated in TAO orbital adipose/connective tissue and validated by qRT-PCR. The study predicted an interaction between circRNA_12367 and hsa-miR-1228-3p, but did not define a downstream mRNA target or functional pathway."	0.5135
32379550	Cancer biotherapy & radiopharmaceuticals	2021	CircFAT1 Suppresses Colorectal Cancer Development Through Regulating miR-520b/UHRF1 Axis or miR-302c-3p/UHRF1 Axis.		circFAT1	hsa_circ_FAT1	FAT1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circFAT1 is up-regulated in colorectal cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes CRC cell proliferation, cell cycle progression, glycolysis and xenograft tumor growth while inhibiting apoptosis, mainly through sponging miR-520b and miR-302c-3p to increase UHRF1 expression."	0.7177
26884878	International journal of clinical and experimental pathology	2015	Decreased expression of hsa_circ_001988 in colorectal cancer and its clinical significances.		hsa_circ_001988	hsa_circ_FBXW7	FBXW7	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; RNA-seq	"This study validated the existence of hsa_circ_001988 in human colorectal cancer tissues and normal mucosa, and showed that it is significantly down-regulated in colorectal cancer. Its expression was associated with tumor differentiation and perineural invasion, and ROC analysis suggested potential diagnostic biomarker value. No specific molecular mechanism or interacting miRNA/protein axis was experimentally defined."	0.5958
27158380	American journal of translational research	2016	Circular RNA: a novel biomarker for progressive laryngeal cancer.		hsa_circRNA_100855			laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_100855 is significantly up-regulated in LSCC tissues and is the most upregulated circRNA identified in the microarray screen. Its higher expression is associated with more advanced clinicopathological features, suggesting potential value as a biomarker for LSCC progression."	0.5541
27158380	American journal of translational research	2016	Circular RNA: a novel biomarker for progressive laryngeal cancer.		hsa_circRNA_104912			laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_104912 is significantly down-regulated in LSCC tissues and is the most downregulated circRNA identified in the microarray screen. Its lower expression is associated with more advanced and aggressive clinicopathological features, suggesting potential value as a biomarker for LSCC progression."	0.5541
28727484	"Cell cycle (Georgetown, Tex.)"	2017	Construction and analysis of circular RNA molecular regulatory networks in liver cancer.		hsa_circRNA_103809 / hsa_circ_10072088	hsa_circ_ZFR	ZFR	liver cancer	MONDO:0002691	liver cancer	up-regulated	RT-qPCR; Microarray	circZFR was significantly up-regulated in liver cancer tissues and validated by qRT-PCR. It may function through predicted interactions with multiple miRNAs in a circRNA-miRNA-mRNA network and showed diagnostic potential for distinguishing liver cancer samples.	0.5047
28727484	"Cell cycle (Georgetown, Tex.)"	2017	Construction and analysis of circular RNA molecular regulatory networks in liver cancer.	hsa_circ_0003028	circFUT8 / hsa_circRNA_101368	hsa_circ_FUT8	FUT8	liver cancer	MONDO:0002691	liver cancer	up-regulated	RT-qPCR; Microarray	"circFUT8 was significantly up-regulated in liver cancer tissues and validated by qRT-PCR. The study predicted that circFUT8 may competitively bind miR-570-3p, miR-17-3p, and miR-552-3p to affect target genes, and ROC analysis suggested diagnostic biomarker potential."	0.5047
28727484	"Cell cycle (Georgetown, Tex.)"	2017	Construction and analysis of circular RNA molecular regulatory networks in liver cancer.	hsa_circ_0007915	circIPO11 / hsa_circRNA_103847	hsa_circ_IPO11	IPO11	liver cancer	MONDO:0002691	liver cancer	up-regulated	RT-qPCR; Microarray	"circIPO11 was significantly up-regulated in liver cancer tissues and validated by qRT-PCR. It was predicted to interact with miR-659-3p, miR-424-5p, and miR-106a-3p in a ceRNA network and showed diagnostic potential by ROC analysis."	0.5047
28727484	"Cell cycle (Georgetown, Tex.)"	2017	Construction and analysis of circular RNA molecular regulatory networks in liver cancer.		hsa_circRNA_102399	hsa_circ_CNN2	CNN2	liver cancer	MONDO:0002691	liver cancer	up-regulated	Microarray	"hsa_circRNA_102399 was identified by microarray as one of the top-5 up-regulated circRNAs in liver cancer tissues. It was included in the predicted circRNA-miRNA-mRNA regulatory network, but the article did not report a positive RT-qPCR validation or specific diagnostic result for this circRNA."	0.348
28727484	"Cell cycle (Georgetown, Tex.)"	2017	Construction and analysis of circular RNA molecular regulatory networks in liver cancer.		hsa_circRNA_103639	hsa_circ_DCUN1D4	DCUN1D4	liver cancer	MONDO:0002691	liver cancer	up-regulated	Microarray	"hsa_circRNA_103639 was identified by microarray as one of the top-5 up-regulated circRNAs in liver cancer tissues. It was included in the predicted circRNA-miRNA-mRNA regulatory network, but the article did not report a positive RT-qPCR validation or specific diagnostic result for this circRNA."	0.348
28739726	Anticancer research	2017	HIF1alpha-associated circDENND4C Promotes Proliferation of Breast Cancer Cells in Hypoxic Environment.		circDENND4C	hsa_circ_DENND4C	DENND4C	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circDENND4C is an HIF1alpha-associated circRNA up-regulated in breast cancer tissues and in breast cancer cells under hypoxia. Its knockdown suppresses proliferation of MDA-MB-231 cells specifically in hypoxic conditions, and its expression is positively correlated with HIF1alpha mRNA and larger tumor size, suggesting potential clinical biomarker value."	0.5546
28744405	American journal of cancer research	2017	Circular RNA circ-ABCB10 promotes breast cancer proliferation and progression through sponging miR-1271.	hsa_circ_0008717	circ-ABCB10	hsa_circ_ABCB10	ABCB10	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circ-ABCB10 is a human ABCB10-derived circRNA that is significantly up-regulated in breast cancer tissues and cell lines. It acts as an oncogenic circRNA by promoting proliferation and cell cycle progression while suppressing apoptosis, at least partly through sponging miR-1271."	0.7785
29218114	American journal of translational research	2017	Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.		ciRNA11			esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"ciRNA11 was one of the top five most up-regulated circRNA candidates in SHEEC esophageal carcinoma cells compared with SHEE cells. Its disease association was supported by RNA-seq and qRT-PCR validation, with predicted involvement in cancer-related regulatory processes."	0.3858
29218114	American journal of translational research	2017	Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.		circRNA904			esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RNA-seq	"circRNA904 was identified by RNA sequencing as one of the top five most up-regulated circRNA candidates in SHEEC cells, but its qRT-PCR validation contradicted sequencing. Therefore, its ESCC-associated expression change is supported only at low confidence."	0.1768
29218114	American journal of translational research	2017	Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.		circRNA3594			esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circRNA3594 was one of the top five most up-regulated circRNA candidates in SHEEC cells compared with SHEE cells. Its expression change was supported by RNA-seq and qRT-PCR validation, while functional involvement was predicted through bioinformatics analyses."	0.3858
29218114	American journal of translational research	2017	Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.		ciRNA101			esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"ciRNA101 was one of the top five most up-regulated circRNA candidates in SHEEC cells. Its expression dysregulation was supported by RNA sequencing and qRT-PCR, and its potential role was inferred from the study-wide circRNA-miRNA and pathway analyses."	0.3858
29218114	American journal of translational research	2017	Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.		cir-cRNA1241			esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"cir-cRNA1241 was identified as one of the top five most up-regulated circRNAs in malignant SHEEC cells. The study supports its ESCC-associated dysregulation by RNA-seq and qRT-PCR, with biological relevance inferred from pathway and circRNA-miRNA analyses."	0.3858
29218114	American journal of translational research	2017	Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.		circRNA9864			esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	RT-qPCR; RNA-seq	"circRNA9864 was one of the top five most down-regulated circRNA candidates in SHEEC cells. Its dysregulation was supported by RNA-seq and qRT-PCR validation, with possible involvement in ESCC-related cellular processes inferred from global pathway analysis."	0.3858
29218114	American journal of translational research	2017	Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.		circ-RNA9650			esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	RT-qPCR; RNA-seq	"circ-RNA9650 was identified as one of the top five most down-regulated circRNA candidates in SHEEC cells. The association was supported by RNA-seq and qRT-PCR validation, while biological relevance was inferred from global enrichment analyses."	0.3858
29218114	American journal of translational research	2017	Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.		circRNA9865			esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	RT-qPCR; RNA-seq	"circRNA9865 was identified as one of the top five most down-regulated circRNA candidates in malignant SHEEC cells. Its expression association was supported by sequencing and qRT-PCR, with potential functional links inferred from study-wide pathway analyses."	0.3858
29218114	American journal of translational research	2017	Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.		circRNA9671			esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	RT-qPCR; RNA-seq	"circRNA9671 was among the top five most down-regulated circRNA candidates in SHEEC cells. Its differential expression was supported by RNA-seq and qRT-PCR, and it was included in the study's broader prediction of cancer-associated circRNA functions."	0.3858
29218114	American journal of translational research	2017	Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.		circ-RNA9930			esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	down-regulated	RT-qPCR; RNA-seq	"circ-RNA9930 was among the top five most down-regulated circRNA candidates in SHEEC cells. Its expression pattern was supported by RNA-seq and qRT-PCR, while its functional relevance was inferred from the global circRNA pathway analyses."	0.3858
29218114	American journal of translational research	2017	Comparative transcriptome analysis of the global circular RNAs expression profiles between SHEE and SHEEC cell lines.		circRNA9927-NBEAL1	hsa_circ_NBEAL1	NBEAL1	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	dysregulated	RNA-seq	circRNA9927-NBEAL1 was highlighted as the largest node in the predicted circRNA-miRNA interaction network derived from dysregulated circRNAs in SHEEC versus SHEE cells. Its role remains computationally predicted and was not individually validated by qRT-PCR or functional assays.	0.1768
29364478	European review for medical and pharmacological sciences	2018	Silencing of hsa_circ_0007534 suppresses proliferation and induces apoptosis in colorectal cancer cells.	hsa_circ_0007534		hsa_circ_DDX42	DDX42	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0007534 is up-regulated in colorectal cancer tissues and CRC cell lines. Its knockdown suppresses proliferation and induces apoptosis in SW620 and LoVo cells, accompanied by increased caspase-3 activity and reduced Bcl-2/Bax ratio. Clinically, higher hsa_circ_0007534 expression is associated with advanced tumor stage and lymph node metastasis, suggesting potential biomarker and therapeutic relevance."	0.7046
29424892	European review for medical and pharmacological sciences	2018	A novel prognostic biomarker for cholangiocarcinoma: circRNA Cdr1as.		circRNA Cdr1as / Cdr1as			cholangiocarcinoma / CCA	MONDO:0019087	cholangiocarcinoma	up-regulated	RT-qPCR	"This study found that circRNA Cdr1as is upregulated in cholangiocarcinoma tumor tissues compared with adjacent normal tissues. High Cdr1as expression is associated with advanced disease features and worse overall survival, supporting its role as an independent prognostic biomarker for CCA. The study did not experimentally define the molecular mechanism of Cdr1as in cholangiocarcinoma."	0.4992
29511454	American journal of translational research	2018	Extensive profiling of circular RNAs and the potential regulatory role of circRNA-000284 in cell proliferation and invasion of cervical cancer via sponging miR-506.		circRNA-000284	hsa_circ_HIPK3	HIPK3	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"circRNA-000284 is up-regulated in cervical cancer cell lines and promotes proliferation and invasion. Mechanistically, it functions as a miR-506 sponge, thereby positively regulating Snail-2 and contributing to cervical cancer progression. The study suggests circRNA-000284 may be a therapeutic target and potential diagnostic/prognostic marker."	0.7006
29511454	American journal of translational research	2018	Extensive profiling of circular RNAs and the potential regulatory role of circRNA-000284 in cell proliferation and invasion of cervical cancer via sponging miR-506.		circRNA-102049			cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	circRNA-102049 was identified as an up-regulated circRNA in cervical cancer cell lines by microarray and RT-qPCR. The study did not pursue a mechanism for this circRNA and reported that ectopic expression had no effect on cell viability.	0.4062
29511454	American journal of translational research	2018	Extensive profiling of circular RNAs and the potential regulatory role of circRNA-000284 in cell proliferation and invasion of cervical cancer via sponging miR-506.		circRNA-001622			cervical cancer / CC	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR; Microarray	"circRNA-001622 was reported among RT-qPCR-validated differentially expressed circRNAs in cervical cancer cell lines, likely down-regulated based on the results description. No molecular mechanism was reported, and ectopic expression had no effect on cell viability."	0.4062
29511454	American journal of translational research	2018	Extensive profiling of circular RNAs and the potential regulatory role of circRNA-000284 in cell proliferation and invasion of cervical cancer via sponging miR-506.		circRNA-104892			cervical cancer / CC	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR; Microarray	"circRNA-104892 was reported among RT-qPCR-validated differentially expressed circRNAs in cervical cancer cell lines, likely down-regulated based on the results description. No molecular mechanism was reported, and ectopic expression had no effect on cell viability."	0.4062
29636867	American journal of translational research	2018	Microarray expression profiling and bioinformatics analysis of circular RNA expression in lung squamous cell carcinoma.		hsa_circRNA_103827			lung squamous cell carcinoma / LSCC	MONDO:0005097	squamous cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_103827 was up-regulated in LSCC tissues and validated by qRT-PCR. It was predicted to interact with several miRNAs, including hsa-miR-129-5p, and high expression was associated with poor overall survival, suggesting potential prognostic biomarker value."	0.5963
29636867	American journal of translational research	2018	Microarray expression profiling and bioinformatics analysis of circular RNA expression in lung squamous cell carcinoma.		hsa_circRNA_103829	hsa_circ_HMGCS1	HMGCS1	lung squamous cell carcinoma / LSCC	MONDO:0005097	squamous cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_103829 was identified as an up-regulated key circRNA in LSCC and validated by qRT-PCR. It was predicted to interact with multiple miRNAs, suggesting a possible miRNA-sponge role in LSCC carcinogenesis."	0.5135
29636867	American journal of translational research	2018	Microarray expression profiling and bioinformatics analysis of circular RNA expression in lung squamous cell carcinoma.		hsa_circRNA_026195	hsa_circ_RACGAP1	RACGAP1	lung squamous cell carcinoma / LSCC	MONDO:0005097	squamous cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_026195 was identified as an up-regulated key circRNA in LSCC and validated by qRT-PCR. Bioinformatic prediction indicated potential interactions with several miRNAs, supporting a possible ceRNA-related role."	0.5135
29636867	American journal of translational research	2018	Microarray expression profiling and bioinformatics analysis of circular RNA expression in lung squamous cell carcinoma.		hsa_circRNA_104852	hsa_circ_RAD23B	RAD23B	lung squamous cell carcinoma / LSCC	MONDO:0005097	squamous cell lung carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circRNA_104852 was up-regulated in LSCC and confirmed by qRT-PCR. Predicted miRNA interactions suggest it may contribute to LSCC carcinogenesis through a miRNA-related regulatory mechanism.	0.5135
29636867	American journal of translational research	2018	Microarray expression profiling and bioinformatics analysis of circular RNA expression in lung squamous cell carcinoma.		hsa_circRNA_103565	hsa_circ_DLG1	DLG1	lung squamous cell carcinoma / LSCC	MONDO:0005097	squamous cell lung carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circRNA_103565 was confirmed as an up-regulated key circRNA in LSCC tissues. Its predicted miRNA interactions suggest a potential regulatory role in LSCC carcinogenesis.	0.5135
29636867	American journal of translational research	2018	Microarray expression profiling and bioinformatics analysis of circular RNA expression in lung squamous cell carcinoma.		hsa_circRNA_103831	hsa_circ_HMGCS1	HMGCS1	lung squamous cell carcinoma / LSCC	MONDO:0005097	squamous cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_103831 was validated as an up-regulated circRNA in LSCC. It was predicted to interact with multiple miRNAs, including hsa-miR-129-5p, indicating a potential miRNA-sponge role."	0.5135
29636867	American journal of translational research	2018	Microarray expression profiling and bioinformatics analysis of circular RNA expression in lung squamous cell carcinoma.		hsa_circRNA_000122	hsa_circ_NBPF10	NBPF10	lung squamous cell carcinoma / LSCC	MONDO:0005097	squamous cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_000122 was down-regulated in LSCC tissues and validated by qRT-PCR. Higher expression was associated with longer survival, while low expression was linked to poor prognosis, suggesting potential biomarker value."	0.5963
29636867	American journal of translational research	2018	Microarray expression profiling and bioinformatics analysis of circular RNA expression in lung squamous cell carcinoma.		hsa_circRNA_102878	hsa_circ_SLC39A10	SLC39A10	lung squamous cell carcinoma / LSCC	MONDO:0005097	squamous cell lung carcinoma	down-regulated	RT-qPCR; Microarray	hsa_circRNA_102878 was confirmed as a down-regulated key circRNA in LSCC. It was predicted to bind multiple miRNAs and may participate in LSCC carcinogenesis through miRNA-circRNA regulatory interactions.	0.5135
29636867	American journal of translational research	2018	Microarray expression profiling and bioinformatics analysis of circular RNA expression in lung squamous cell carcinoma.		hsa_circRNA_002131	hsa_circ_BNIP3L	BNIP3L	lung squamous cell carcinoma / LSCC	MONDO:0005097	squamous cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_002131 was down-regulated in LSCC tissues and validated by qRT-PCR. It was predicted to interact with several miRNAs, suggesting a possible role in LSCC-related miRNA-circRNA regulatory networks."	0.5135
29636867	American journal of translational research	2018	Microarray expression profiling and bioinformatics analysis of circular RNA expression in lung squamous cell carcinoma.		hsa_circRNA_102556	hsa_circ_AXL	AXL	lung squamous cell carcinoma / LSCC	MONDO:0005097	squamous cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_102556 was validated as a down-regulated key circRNA in LSCC tissues. It was predicted to interact with multiple miRNAs, suggesting possible involvement in LSCC carcinogenesis through miRNA-circRNA regulation."	0.5135
29762831	European review for medical and pharmacological sciences	2018	CircRNA_0023642 promotes migration and invasion of gastric cancer cells by regulating EMT.	hsa_circ_0023642	circRNA_0023642			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circRNA_0023642 is up-regulated in gastric cancer tissues and cell lines. It functions as a tumor-promoting circRNA by enhancing proliferation, migration, invasion and EMT while suppressing apoptosis. The study suggests it may be a potential diagnostic and therapeutic marker for gastric cancer."	0.5442
29863250	European review for medical and pharmacological sciences	2018	"CircRNA circ_0067934 silencing inhibits the proliferation, migration and invasion of NSCLC cells and correlates with unfavorable prognosis in NSCLC."	hsa_circ_0067934	circ_0067934			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0067934 is up-regulated in NSCLC tissues and cell lines and acts as an oncogenic circRNA. Its knockdown suppresses NSCLC cell proliferation, migration and invasion, likely through inhibition of EMT marker changes. Clinically, high circ_0067934 expression is associated with advanced disease features and poorer overall survival, suggesting prognostic and therapeutic relevance."	0.6527
29949144	European review for medical and pharmacological sciences	2018	CircHIPK3 is upregulated and predicts a poor prognosis in epithelial ovarian cancer.		circHIPK3	hsa_circ_HIPK3	HIPK3	epithelial ovarian cancer / EOC	MONDO:0005140	ovarian carcinoma	up-regulated	RT-qPCR	"This study found that circHIPK3 is up-regulated in EOC tissues and ovarian cancer cell lines. Higher circHIPK3 expression is associated with lymph node invasion, advanced FIGO stage, shorter DFS and OS, and independently predicts poor prognosis, suggesting its value as a prognostic biomarker for EOC."	0.4758
30018710	American journal of translational research	2018	Hsa_circ_0103809 promotes cell proliferation and inhibits apoptosis in hepatocellular carcinoma by targeting miR-490-5p/SOX2 signaling pathway.	hsa_circ_0103809		hsa_circ_AP4E1	AP4E1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0103809 is up-regulated in HCC tissues and cell lines and is associated with poor prognosis. Functionally, it promotes HCC cell proliferation and migration and suppresses apoptosis. Mechanistically, it acts as a miR-490-5p sponge to derepress SOX2 expression, forming a hsa_circ_0103809/miR-490-5p/SOX2 regulatory axis."	0.8413
30018710	American journal of translational research	2018	Hsa_circ_0103809 promotes cell proliferation and inhibits apoptosis in hepatocellular carcinoma by targeting miR-490-5p/SOX2 signaling pathway.	hsa_circ_0008450				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0008450 was among the top up-regulated circRNAs identified by high-throughput circRNA sequencing and was validated by RT-qPCR as significantly increased in HCC tissues compared with corresponding nontumourous tissues. No functional or mechanistic experiments were reported for this circRNA.	0.5841
30018710	American journal of translational research	2018	Hsa_circ_0103809 promotes cell proliferation and inhibits apoptosis in hepatocellular carcinoma by targeting miR-490-5p/SOX2 signaling pathway.	hsa_circ_0002133				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0002133 was among the top up-regulated circRNAs identified by high-throughput circRNA sequencing and was validated by RT-qPCR as significantly increased in HCC tissues compared with corresponding nontumourous tissues. No functional or mechanistic experiments were reported for this circRNA.	0.5841
30018710	American journal of translational research	2018	Hsa_circ_0103809 promotes cell proliferation and inhibits apoptosis in hepatocellular carcinoma by targeting miR-490-5p/SOX2 signaling pathway.	hsa_circ_0000267				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0000267 was among the top up-regulated circRNAs identified by high-throughput circRNA sequencing and was validated by RT-qPCR as significantly increased in HCC tissues compared with corresponding nontumourous tissues. No functional or mechanistic experiments were reported for this circRNA.	0.5841
30018710	American journal of translational research	2018	Hsa_circ_0103809 promotes cell proliferation and inhibits apoptosis in hepatocellular carcinoma by targeting miR-490-5p/SOX2 signaling pathway.	hsa_circ_0021093				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0021093 was among the top up-regulated circRNAs identified by high-throughput circRNA sequencing and was validated by RT-qPCR as significantly increased in HCC tissues compared with corresponding nontumourous tissues. No functional or mechanistic experiments were reported for this circRNA.	0.5841
30078268	Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology	2018	[Circular RNA circHIPK3 acts as the sponge of microRNA-124 to promote human oral squamous cell carcinoma cells proliferation].	hsa_circ_0000284	circHIPK3	hsa_circ_HIPK3	HIPK3	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in OSCC tissues and OSCC cell lines. The study indicates that circHIPK3 promotes CAL27 and SCC15 cell proliferation, at least partly through regulation of miR-124, and its expression is associated with TNM stage and tumor grade."	0.4862
30112563	Sheng li xue bao : [Acta physiologica Sinica]	2018	[Differentially expressed circular RNAs in human gastric cancer cells].	hsa_circ_0001897				gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	Microarray	hsa_circ_0001897 was down-regulated in gastric cancer cell lines compared with normal gastric epithelial cells based on circRNA microarray data. The authors predicted that it may interact with miR-150-5p and may suppress gastric cancer cell invasion and metastasis.	0.329
30112563	Sheng li xue bao : [Acta physiologica Sinica]	2018	[Differentially expressed circular RNAs in human gastric cancer cells].	hsa_circ_0008106				gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	Microarray	"hsa_circ_0008106 was down-regulated in gastric cancer cell lines according to microarray profiling. Bioinformatic prediction suggested miR-16-5p binding sites, and the authors proposed that hsa_circ_0008106 may suppress gastric cancer cell invasion and metastasis through interaction with miR-16-5p."	0.329
30112563	Sheng li xue bao : [Acta physiologica Sinica]	2018	[Differentially expressed circular RNAs in human gastric cancer cells].	hsa_circ_0060456	hsa_circ_006045			gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	Microarray	hsa_circ_0060456 was down-regulated in gastric cancer cell lines according to circRNA microarray profiling. The study predicted that it has binding sites for miR-16-5p and proposed that it may suppress gastric cancer cell invasion and metastasis through miRNA interaction.	0.329
30187868	Nan fang yi ke da xue xue bao = Journal of Southern Medical University	2018	[Differences in expression profiles of circular RNA between luminal breast cancer cells and normal breast cells].		hsa_circRNA_100689	hsa_circ_GFRA1	GFRA1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_100689 is a GFRA1-associated circRNA up-regulated in MCF7 Luminal breast cancer cells compared with MCF10A normal breast epithelial cells. Its differential expression was detected by circRNA microarray and validated by qPCR, suggesting potential relevance to Luminal breast cancer biology or marker discovery, but its mechanism was not experimentally defined."	0.3401
30187868	Nan fang yi ke da xue xue bao = Journal of Southern Medical University	2018	[Differences in expression profiles of circular RNA between luminal breast cancer cells and normal breast cells].		hsa_circRNA_005239	hsa_circ_GFRA1	GFRA1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_005239 is a GFRA1-associated circRNA up-regulated in MCF7 Luminal breast cancer cells compared with MCF10A normal breast epithelial cells. Its differential expression was detected by circRNA microarray and validated by qPCR, suggesting potential relevance to Luminal breast cancer biology or marker discovery, but its mechanism was not experimentally defined."	0.3401
30187868	Nan fang yi ke da xue xue bao = Journal of Southern Medical University	2018	[Differences in expression profiles of circular RNA between luminal breast cancer cells and normal breast cells].		hsa_circRNA_104864			breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_104864 is a down-regulated circRNA in MCF7 Luminal breast cancer cells compared with MCF10A normal breast epithelial cells. Its differential expression was detected by circRNA microarray and validated by qPCR, but the study did not define its host gene, molecular mechanism, or biological function."	0.3401
30210911	American journal of cancer research	2018	A novel circular RNA hsa_circ_0020123 exerts oncogenic properties through suppression of miR-144 in non-small cell lung cancer.	hsa_circ_0020123				non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0020123 is up-regulated in NSCLC tissues and is associated with advanced clinicopathological features and poor overall survival. Functionally, it promotes NSCLC proliferation, migration, invasion, tumor growth and metastasis and inhibits apoptosis. Mechanistically, it sponges miR-144 to increase ZEB1 and EZH2 expression, forming a hsa_circ_0020123-miR-144-ZEB1/EZH2 ceRNA axis."	0.798
30323971	American journal of cancer research	2018	Altered expression pattern of circular RNAs in metastatic oral mucosal melanoma.	hsa_circ_0005320	hsacirc_0005320	hsa_circ_SEPT9	SEPT9	oral mucosal melanoma / OMM	MONDO:0000544	mucosal melanoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0005320 is significantly upregulated in OMM primary tumors and metastatic lymph nodes. The study predicts that it may function as a ceRNA in OMM progression and metastasis, with potential diagnostic value."	0.5047
30323971	American journal of cancer research	2018	Altered expression pattern of circular RNAs in metastatic oral mucosal melanoma.	hsa_circ_0067531	hsacirc_0067531	hsa_circ_PIK3CB	PIK3CB	oral mucosal melanoma / OMM	MONDO:0000544	mucosal melanoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0067531 is significantly upregulated in OMM cancerous tissues. It is predicted to participate in ceRNA regulation and is linked to MAPK activation, with ROC analysis suggesting diagnostic potential."	0.5047
30323971	American journal of cancer research	2018	Altered expression pattern of circular RNAs in metastatic oral mucosal melanoma.	hsa_circ_0008042		hsa_circ_MYCBP2	MYCBP2	oral mucosal melanoma / OMM	MONDO:0000544	mucosal melanoma	up-regulated	RT-qPCR; Microarray	hsa_circ_0008042 is significantly upregulated in OMM cancerous tissues and validated by qRT-PCR. The study links it to translation repressor activity and notes that its host gene MYCBP2 is relevant to cell cycle progression and proliferation in melanoma cells.	0.4032
30323971	American journal of cancer research	2018	Altered expression pattern of circular RNAs in metastatic oral mucosal melanoma.	hsa_circ_0000869		hsa_circ_GNG7	GNG7	oral mucosal melanoma / OMM	MONDO:0000544	mucosal melanoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0000869 is significantly downregulated in OMM cancerous tissues and metastatic lymph nodes. The study predicts that it may act as a ceRNA through miR-1268a and may regulate OMM metastasis through GPR signaling, with diagnostic potential shown by ROC analysis."	0.5047
30323971	American journal of cancer research	2018	Altered expression pattern of circular RNAs in metastatic oral mucosal melanoma.	hsa_circ_0000853		hsa_circ_MALT1	MALT1	oral mucosal melanoma / OMM	MONDO:0000544	mucosal melanoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0000853 is significantly downregulated in OMM cancerous tissues. It is linked by bioinformatics analysis to NF-kappa B signaling, and its host gene MALT1 is associated with NF-kappa B activation and cancer cell proliferation and migration."	0.4032
30338784	European review for medical and pharmacological sciences	2018	Circular RNA circ-NT5C2 acts as a potential novel biomarker for prognosis of osteosarcoma.	hsa_circ_0092509	circ-NT5C2	hsa_circ_NT5C2	NT5C2	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"This clinical study found that circ-NT5C2/hsa_circ_0092509 is significantly up-regulated in osteosarcoma tissues compared with adjacent normal bone tissues. Higher circ-NT5C2 expression is associated with advanced clinical stage, distant metastasis, shorter OS and DFS, and independent prediction of poor prognosis. The study did not experimentally define a molecular mechanism for circ-NT5C2 in osteosarcoma."	0.4758
30468459	European review for medical and pharmacological sciences	2018	Circular RNA_LARP4 is lower expressed and serves as a potential biomarker of ovarian cancer prognosis.		Circular RNA_LARP4 / circ LARP4	hsa_circ_LARP4	LARP4	ovarian cancer / OC	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR	"This study found that circLARP4 is significantly down-regulated in ovarian cancer tissues compared with adjacent normal tissues. Lower circLARP4 expression is associated with advanced FIGO stage, lymph node metastases, worse DFS and OS, and independent poor prognosis, suggesting circLARP4 may be a prognostic biomarker for ovarian cancer."	0.4758
30509108	Neoplasma	2019	Circ-ITCH regulates triple-negative breast cancer progression through the Wnt/beta-catenin pathway.		circ-ITCH	hsa_circ_ITCH	ITCH	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	down-regulated	RT-qPCR	"Circ-ITCH is down-regulated in TNBC tissues and cell lines and acts as a tumor suppressor. It inhibits TNBC proliferation, migration, invasion, growth and metastasis by sponging miR-214 and miR-17, increasing ITCH expression and inactivating Wnt/beta-catenin signaling. Clinically, low circ-ITCH expression is associated with lymph node metastasis, larger tumor size, advanced TNM stage and shorter survival, supporting its value as a prognostic biomarker."	0.734
30520151	Molecular carcinogenesis	2019	hsa_circRNA_0006528 as a competing endogenous RNA promotes human breast cancer progression by sponging miR-7-5p and activating the MAPK/ERK signaling pathway.	hsa_circ_0006528	circ_0006528	hsa_circ_PRELID2	PRELID2	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0006528 is upregulated in human breast cancer tissues and is associated with advanced TNM stage and poor prognosis. Functionally, it promotes breast cancer cell DNA synthesis, proliferation, invasion, migration, growth and metastasis while inhibiting apoptosis. Mechanistically, circ_0006528 acts as a ceRNA by sponging miR-7-5p, thereby promoting Raf1 expression and activating the MAPK/ERK signalling pathway."	0.7414
30529438	Experimental neurology	2019	Significant changes in circular RNA in the mouse cerebral cortex around an injury site after traumatic brain injury.		"circRNA chr8_87,859,283-87,904,548 / circRNA-chr-8"			traumatic brain injury / TBI	MONDO:0858950	traumatic brain injury	up-regulated	RT-qPCR; RNA-seq	"In a mouse controlled cortical impact model of traumatic brain injury, circRNA chr8_87,859,283-87,904,548 was up-regulated in the peri-contusion cerebral cortex. It acts as a sponge for mmu-let-7a-5p, thereby increasing CXCR2 protein production, promoting neuroinflammation, and impairing neurological functional recovery after TBI."	0.6528
30537731	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	circZMYM2 Competed Endogenously with miR-335-5p to Regulate JMJD2C in Pancreatic Cancer.	hsa_circ_0099999	circZMYM2	hsa_circ_ZMYM2	ZMYM2	pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; Microarray	"circZMYM2 is up-regulated in pancreatic cancer tissues and cell lines. It promotes PC cell proliferation, invasion and in vivo tumor growth while inhibiting apoptosis, acting through a circZMYM2/miR-335-5p/JMJD2C ceRNA axis."	0.7795
30537738	"Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology"	2018	Circular RNA circPVT1 Promotes Proliferation and Invasion Through Sponging miR-125b and Activating E2F2 Signaling in Non-Small Cell Lung Cancer.		circPVT1	hsa_circ_PVT1	PVT1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circPVT1 is up-regulated in NSCLC tissues, serum and cell lines, and shows diagnostic biomarker potential. Mechanistically, c-Fos activates circPVT1 expression, and circPVT1 promotes NSCLC proliferation, invasion, metastasis-related phenotypes and xenograft tumor growth by sponging miR-125b and activating the E2F2 pathway."	0.8769
30556849	European review for medical and pharmacological sciences	2018	Circular RNA ITCH suppresses proliferation and promotes apoptosis in human epithelial ovarian cancer cells by sponging miR-10a-alpha.		Circular RNA Itchy E3 ubiquitin protein ligase / Circ-ITCH	hsa_circ_ITCH	Itchy E3 ubiquitin protein ligase	epithelial ovarian cancer / EOC	MONDO:0005140	ovarian carcinoma	down-regulated	RT-qPCR	"Circ-ITCH is down-regulated in human epithelial ovarian cancer cell lines compared with normal ovarian epithelial cells. In SKOV3 cells, Circ-ITCH suppresses proliferation and promotes apoptosis, mainly through targeting/sponging miR-10a, suggesting a potential therapeutic relevance in EOC."	0.4376
30556859	European review for medical and pharmacological sciences	2018	CircMTO1 inhibits cell proliferation and invasion by regulating Wnt/beta-catenin signaling pathway in colorectal cancer.		circMTO1	hsa_circ_MTO1	MTO1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"circMTO1 is down-regulated in colorectal cancer tissues and cell lines, and low expression is associated with advanced TNM stage, lymph node metastasis, and poor overall survival. Functionally, circMTO1 suppresses CRC cell proliferation, migration, and invasion, at least partly by inhibiting the Wnt/beta-catenin signaling pathway and its downstream targets beta-catenin, c-myc, and cyclin D1."	0.6591
30556864	European review for medical and pharmacological sciences	2018	Circ_0009910 regulates growth and metastasis and is associated with poor prognosis in gastric cancer.	hsa_circ_0009910	circ_0009910			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_0009910 is up-regulated in gastric cancer tissues and cell lines and is associated with advanced clinicopathological features and poor overall survival. Functionally, circ_0009910 promotes proliferation, colony formation, migration, invasion, and EMT of gastric cancer cells, suggesting its value as a prognostic biomarker and potential therapeutic target."	0.6568
30570857	Journal of B.U.ON. : official journal of the Balkan Union of Oncology	2018	Circ-ZNF609 promotes migration of colorectal cancer by inhibiting Gli1 expression via microRNA-150.		Circ-ZNF609	hsa_circ_ZNF609	ZNF609	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"Circ-ZNF609 is up-regulated in colorectal cancer tissues and is predominantly cytoplasmic in HCT116 cells. It binds microRNA-150 and positively regulates Gli1 expression, thereby promoting colorectal cancer cell migration."	0.6676
30575898	European review for medical and pharmacological sciences	2018	"Involvement of circular RNA SMARCA5/microRNA-620 axis in the regulation of cervical cancer cell proliferation, invasion and migration."	hsa_circ_0001445	circular RNA SMARCA5 / circSMARCA5	hsa_circ_SMARCA5	SMARCA5	cervical cancer / CC	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR	"circSMARCA5/hsa_circ_0001445 is downregulated in cervical cancer tissues and cells. Functionally, circSMARCA5 suppresses cervical cancer cell proliferation, migration and invasion and induces cell cycle arrest. Mechanistically, circSMARCA5 binds and inhibits miR-620, suggesting a circSMARCA5/miR-620 regulatory axis with potential therapeutic relevance."	0.7177
30575911	European review for medical and pharmacological sciences	2018	"Circular RNA ciRS-7 correlates with advance disease and poor prognosis, and its down-regulation inhibits cells proliferation while induces cells apoptosis in non-small cell lung cancer."		circRNA ciRS-7 / cerebellar-degeneration-related protein 1 antisense RNA (CDR1as)			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"In this study, circRNA ciRS-7 was up-regulated in NSCLC tumor tissues and NSCLC cell lines. High tumor tissue expression correlated with advanced clinicopathological features and poorer DFS/OS, while experimental down-regulation in A549 cells suppressed proliferation and promoted apoptosis, suggesting an oncogenic role and potential clinical prognostic value in NSCLC."	0.6419
30575918	European review for medical and pharmacological sciences	2018	Has_circ_0008274 promotes cell proliferation and invasion involving AMPK/mTOR signaling pathway in papillary thyroid carcinoma.	hsa_circ_0008274	circ_0008274	hsa_circ_UGGT2	UGGT2	papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"This study reports that has_circ_0008274 is up-regulated in papillary thyroid carcinoma tissues and cell lines. Functional knockdown experiments indicate that has_circ_0008274 promotes PTC cell proliferation and invasion, and the proposed mechanism involves modulation of the AMPK/mTOR signaling pathway. Its expression is associated with TNM stage and lymph node metastasis, suggesting potential clinical relevance as a therapeutic target."	0.6093
30640591	Bosnian journal of basic medical sciences	2019	CircRNA_014511 affects the radiosensitivity of bone marrow mesenchymal stem cells by binding to miR-29b-2-5p.		circRNA_014511 / mmu_circRNA_014511			TBI-induced bone marrow damage	MONDO:0033938	acute radiation syndrome	up-regulated	Microarray	"circRNA_014511 is up-regulated in BMMSCs from TBI-treated mice and was functionally studied in mouse BMMSCs. Its overexpression adsorbs mmu-miR-29b-2-5p, suppresses P53 expression, alters apoptosis- and cell-cycle-related proteins, reduces apoptosis, and decreases BMMSC radiosensitivity after irradiation."	0.5979
30662602	American journal of translational research	2018	"Circ5379-6, a circular form of tumor suppressor PPARalpha, participates in the inhibition of hepatocellular carcinoma tumorigenesis and metastasis."		circ5379-6 / hsa-circRNA5379-6	hsa_circ_PPARalpha	PPARalpha	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	unknown	RT-qPCR	"circ5379-6 is a circular RNA derived from the tumor suppressor PPARalpha. In HCC cell lines and nude mouse models, circ5379-6 overexpression suppresses proliferation, migration, invasion, tumorigenesis and metastasis while inducing apoptosis. Its inhibitory effect is associated with partial reversal of EMT-related changes, including decreased MMP-9, Vimentin and N-cadherin and increased E-cadherin."	0.7587
30672444	"Cellular and molecular biology (Noisy-le-Grand, France)"	2018	Hsa_circRNA_0059655 plays a role in salivary adenoid cystic carcinoma by functioning as a sponge of miR-338-3p.	hsa_circ_0059655		hsa_circ_PYGB	PYGB	salivary adenoid cystic carcinoma / SACC	MONDO:0003175	salivary gland adenoid cystic carcinoma	dysregulated	Microarray	"This study identified hsa_circ_0059655 as a PYGB-derived circRNA involved in SACC. It may act as a miR-338-3p sponge and regulate CCND1-related ceRNA signaling, thereby promoting proliferation, migration, and invasion of SACC-83 cells. Its disease-expression evidence is based on microarray profiling rather than RT-qPCR validation in clinical samples."	0.6093
30720163	European review for medical and pharmacological sciences	2019	Circular RNA hsa_circ_103809 suppresses hepatocellular carcinoma proliferation and invasion by sponging miR-620.		hsa_circ_103809	hsa_circ_ZFR	ZFR	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_103809 is a ZFR-derived human circRNA that is down-regulated in HCC tissues and cell lines. It mainly localizes in the cytoplasm and suppresses HCC cell proliferation, colony formation, migration and invasion by binding to and down-regulating miR-620. Its reduced expression is associated with aggressive clinicopathological features, suggesting biomarker and therapeutic potential in HCC."	0.7884
30787976	American journal of translational research	2019	RNA-Seq profiling of circular RNAs and potential function of hsa_circ_0002360 in human lung adenocarcinom.	hsa_circ_0002360				lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; RNA-seq	"This study identifies hsa_circ_0002360 as an up-regulated circRNA in human lung adenocarcinoma tissues, validated by qRT-PCR after circRNA sequencing. The authors propose a hsa_circ_0002360/hsa-mir-3620-5p/PHF19 regulatory axis, in which increased hsa_circ_0002360 may suppress hsa-mir-3620-5p and increase PHF19 expression, contributing to LAC pathogenesis and suggesting therapeutic potential."	0.7352
30816475	Molecular medicine reports	2019	circRNA_CER mediates malignant progression of breast cancer through targeting the miR_136/MMP13 axis.		circRNA-CER / chondrocyte extracellular matrix-related circular RNA			breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circRNA-CER is upregulated in breast cancer tissues and promotes malignant phenotypes in breast cancer cells. Mechanistically, circRNA-CER acts as a miR-136 sponge to regulate MMP13 expression, thereby supporting MCF-7 cell proliferation and migration. The study proposes circRNA-CER as a potential biomarker or molecular target for breast cancer prediction, diagnosis and treatment."	0.6148
30844715	Frontiers in bioscience (Landmark edition)	2019	"CircRNA_104916 regulates migration, apoptosis and epithelial-mesenchymal transition in colon cancer cells."		CircRNA_104916	hsa_circ_NEK6	NEK6	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"CircRNA_104916 is downregulated in colorectal cancer tissues and cell lines, and higher expression is associated with better disease-free survival. Functional experiments show that circRNA_104916 overexpression suppresses CRC proliferation, migration, invasion and EMT, while promoting apoptosis and G2/M phase arrest. The study supports circRNA_104916 as a potential tumor suppressor, biomarker and therapeutic target in CRC."	0.6589
30864721	Molecular medicine reports	2019	CircRNA_0044073 is upregulated in atherosclerosis and increases the proliferation and invasion of cells by targeting miR_107.	hsa_circ_0044073	circRNA-0044073			atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"circRNA-0044073 is upregulated in blood cells from patients with atherosclerosis. It promotes vascular smooth muscle and endothelial cell proliferation and invasion by sponging miR-107, thereby activating the JAK1/STAT3 pathway and increasing downstream pro-proliferative and inflammatory mediators. The study proposes circRNA-0044073 as a potential therapeutic target for atherosclerosis."	0.6825
30922567	Biochemical and biophysical research communications	2019	Circular RNA PVT1 promotes metastasis via miR-145 sponging in CRC.	hsa_circ_0001821	Circular RNA PVT1 / circPVT1	hsa_circ_PVT1	PVT1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"In this study, circPVT1 was upregulated in colorectal cancer tissues and cell lines and high expression was associated with poor clinicopathological features and shorter survival. Functionally, circPVT1 promoted CRC cell migration, invasion and metastasis. Mechanistically, cytoplasmic circPVT1 acted as a miR-145 sponge, and the circPVT1/miR-145 axis was proposed as a potential therapeutic target in CRC."	0.7586
30972190	American journal of translational research	2019	"Circular RNA hsa_circ_0002024 suppresses cell proliferation, migration, and invasion in bladder cancer by sponging miR-197-3p."	hsa_circ_0002024				bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR	"hsa_circ_0002024 is downregulated in bladder cancer tissues and cell lines. Its upregulation suppresses BC cell proliferation, migration, and invasion, at least in part by sponging and negatively regulating miR-197-3p. The study suggests hsa_circ_0002024 as a potential therapeutic target for bladder cancer."	0.6479
31002133	European review for medical and pharmacological sciences	2019	CircRNA ZNF609 promotes growth and metastasis of nasopharyngeal carcinoma by competing with microRNA-150-5p.	hsa_circ_0000615	circular RNA ZNF609 / circ-ZNF609	hsa_circ_ZNF609	ZNF609	nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"circ-ZNF609 is up-regulated in nasopharyngeal carcinoma tissues and cell lines. It promotes NPC cell proliferation, migration, invasion and metastatic ability by acting as a ceRNA that binds microRNA-150-5p and upregulates Sp1. The study suggests circ-ZNF609 may be a diagnostic hallmark and therapeutic target for NPC."	0.7404
31081084	European review for medical and pharmacological sciences	2019	Hsa_circ_0005075 predicts a poor prognosis and acts as an oncogene in colorectal cancer via activating Wnt/beta-catenin pathway.	hsa_circ_0005075	circ_0005075			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"hsa_circ_0005075/circ_0005075 is up-regulated in colorectal cancer tissues and cell lines and its high expression predicts poorer overall and disease-free survival. Functionally, circ_0005075 promotes CRC cell proliferation, migration, invasion, EMT and metastasis while suppressing apoptosis. Mechanistically, the study supports an oncogenic role through activation of the Wnt/beta-catenin pathway."	0.6589
31081091	European review for medical and pharmacological sciences	2019	Enhanced expression of circular RNA hsa_circ_000984 promotes cells proliferation and metastasis in non-small cell lung cancer by modulating Wnt/beta-catenin pathway.		hsa_circ_000984	hsa_circ_CDK6	CDK6	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_000984 is up-regulated in NSCLC tissues and cell lines and functions as an oncogenic circRNA. Its knockdown suppresses proliferation, colony formation, migration, invasion, EMT and Wnt/beta-catenin signaling while increasing apoptosis, and high expression predicts poor survival in NSCLC patients."	0.6589
31081099	European review for medical and pharmacological sciences	2019	Up-regulated circular RNA hsa_circ_0067934 contributes to glioblastoma progression through activating PI3K-AKT pathway.	hsa_circ_0067934				glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR	"This study reports that hsa_circ_0067934 is up-regulated in human GBM tissues and cell lines and that high expression is associated with poorer overall and disease-free survival. Functional knockdown experiments indicate that hsa_circ_0067934 promotes GBM cell proliferation, migration, invasion, metastasis and EMT while suppressing apoptosis. Mechanistically, the study links its oncogenic role to activation of the PI3K-AKT signaling pathway."	0.6589
31105852	American journal of translational research	2019	A novel circular RNA hsa_circ_0008035 contributes to gastric cancer tumorigenesis through targeting the miR-375/YBX1 axis.	hsa_circ_0008035		hsa_circ_EXT1	EXT1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0008035 is an up-regulated circRNA in gastric cancer tissues and cells. It promotes gastric cancer cell proliferation, invasion and metastasis-related phenotypes by functioning as a miR-375 sponge and regulating the miR-375/YBX1 axis."	0.6815
31127997	Journal of B.U.ON. : official journal of the Balkan Union of Oncology	2019	Circular RNA-100219 promotes breast cancer progression by binding to microRNA-485-3p.		circ-100219 / circ-10021			breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ-100219 is up-regulated in breast cancer tissues and cell lines, with higher expression in advanced-stage tumors. Functionally, circ-100219 promotes breast cancer cell proliferation and migration by binding/sponging microRNA-485-3p and increasing NTRK3 expression. The study suggests circ-100219 may have diagnostic and therapeutic relevance in breast cancer."	0.6479
31137165	Zhonghua zhong liu za zhi [Chinese journal of oncology]	2019	[Differences in circRNA expression profiles between HER-2-positive breast cancer cells and normal mammary epithelial cells].		hsa_circRNA_074595			HER-2 positive breast cancer	MONDO:0006244	HER2 positive breast carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_074595 was up-regulated in HER-2-positive SK-BR-3 breast cancer cells compared with MCF10A cells and was validated by RT-qPCR. The study suggests it may be a potential diagnostic or therapeutic target, with mechanisms inferred from global circRNA-miRNA network and PI3K-Akt pathway enrichment analyses."	0.3858
31137165	Zhonghua zhong liu za zhi [Chinese journal of oncology]	2019	[Differences in circRNA expression profiles between HER-2-positive breast cancer cells and normal mammary epithelial cells].		hsa_circRNA_074598			HER-2 positive breast cancer	MONDO:0006244	HER2 positive breast carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_074598 was up-regulated in HER-2-positive SK-BR-3 breast cancer cells compared with MCF10A cells and was validated by RT-qPCR. It is proposed as a potential diagnostic or therapeutic target, with possible involvement in circRNA-miRNA regulatory networks and PI3K-Akt-related processes."	0.3858
31137165	Zhonghua zhong liu za zhi [Chinese journal of oncology]	2019	[Differences in circRNA expression profiles between HER-2-positive breast cancer cells and normal mammary epithelial cells].		hsa_circRNA_085362			HER-2 positive breast cancer	MONDO:0006244	HER2 positive breast carcinoma	up-regulated	Microarray	"hsa_circRNA_085362 was identified by circRNA microarray as up-regulated in HER-2-positive SK-BR-3 breast cancer cells. It was not individually validated by RT-qPCR, but was included among differentially expressed circRNAs proposed as potential diagnostic or therapeutic targets."	0.329
31137165	Zhonghua zhong liu za zhi [Chinese journal of oncology]	2019	[Differences in circRNA expression profiles between HER-2-positive breast cancer cells and normal mammary epithelial cells].		hsa_circRNA_101379			HER-2 positive breast cancer	MONDO:0006244	HER2 positive breast carcinoma	up-regulated	Microarray	"hsa_circRNA_101379 was identified by microarray as up-regulated in HER-2-positive SK-BR-3 breast cancer cells. It was not individually RT-qPCR-validated, but belongs to the differentially expressed circRNA set suggested to have diagnostic or therapeutic potential."	0.329
31137165	Zhonghua zhong liu za zhi [Chinese journal of oncology]	2019	[Differences in circRNA expression profiles between HER-2-positive breast cancer cells and normal mammary epithelial cells].		hsa_circRNA_406683			HER-2 positive breast cancer	MONDO:0006244	HER2 positive breast carcinoma	up-regulated	Microarray	"hsa_circRNA_406683 was identified by microarray as up-regulated in HER-2-positive SK-BR-3 breast cancer cells. The study proposes differentially expressed circRNAs such as this one as candidate diagnostic or therapeutic targets, although this circRNA was not individually RT-qPCR-validated."	0.329
31137165	Zhonghua zhong liu za zhi [Chinese journal of oncology]	2019	[Differences in circRNA expression profiles between HER-2-positive breast cancer cells and normal mammary epithelial cells].		hsa_circRNA_021714			HER-2 positive breast cancer	MONDO:0006244	HER2 positive breast carcinoma	down-regulated	Microarray	"hsa_circRNA_021714 was identified by microarray as down-regulated in HER-2-positive SK-BR-3 breast cancer cells. It was not individually validated by RT-qPCR, but was part of the differentially expressed circRNA set considered to have potential clinical value."	0.329
31137165	Zhonghua zhong liu za zhi [Chinese journal of oncology]	2019	[Differences in circRNA expression profiles between HER-2-positive breast cancer cells and normal mammary epithelial cells].		hsa_circRNA_100777			HER-2 positive breast cancer	MONDO:0006244	HER2 positive breast carcinoma	down-regulated	RT-qPCR; Microarray	hsa_circRNA_100777 was down-regulated in HER-2-positive SK-BR-3 breast cancer cells compared with MCF10A cells and was validated by RT-qPCR. The study suggests this differentially expressed circRNA may have potential as a diagnostic or therapeutic target.	0.3858
31137165	Zhonghua zhong liu za zhi [Chinese journal of oncology]	2019	[Differences in circRNA expression profiles between HER-2-positive breast cancer cells and normal mammary epithelial cells].		hsa_circRNA_100796			HER-2 positive breast cancer	MONDO:0006244	HER2 positive breast carcinoma	down-regulated	Microarray	"hsa_circRNA_100796 was identified by microarray as down-regulated in HER-2-positive SK-BR-3 breast cancer cells. It was not individually RT-qPCR-validated, but is part of the study's differentially expressed circRNA set with proposed diagnostic or therapeutic relevance."	0.329
31210299	European review for medical and pharmacological sciences	2019	Circ-0104631 promotes cell proliferation and invasion in colorectal cancer and predicts poor prognosis.	hsa_circ_0104631	Circ-0104631			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"Circ-0104631 is up-regulated in colorectal cancer tissues and CRC cell lines, and its high expression is associated with advanced TNM stage, distant metastasis, and poor patient survival. Functionally, Circ-0104631 promotes CRC cell proliferation, invasion, growth and metastasis, likely through suppression of PTEN and activation of the AKT/mTOR signaling pathway. The study proposes Circ-0104631 as a potential prognostic marker and therapeutic target in CRC."	0.6194
31257480	Molecular medicine reports	2019	Circular RNA sequencing reveals the molecular mechanism of the effects of acupuncture and moxibustion on endometrial receptivity in patients undergoing infertility treatment.		circ-SFMBT2	hsa_circ_SFMBT2	SFMBT2	infertility	MONDO:0005047	infertility disorder	up-regulated	RT-qPCR; RNA-seq	"circ-SFMBT2 was significantly upregulated in endometrial samples from infertile patients receiving acupuncture and moxibustion. It was incorporated into a predicted circRNA-miR-mRNA network, suggesting a possible ceRNA-related role in acupuncture/moxibustion-mediated modulation of endometrial receptivity."	0.4032
31257480	Molecular medicine reports	2019	Circular RNA sequencing reveals the molecular mechanism of the effects of acupuncture and moxibustion on endometrial receptivity in patients undergoing infertility treatment.		circ-BACH1	hsa_circ_BACH1	BACH1	infertility	MONDO:0005047	infertility disorder	up-regulated	RT-qPCR; RNA-seq	circBACH1 was significantly upregulated in endometrial samples from infertile patients receiving acupuncture and moxibustion. The study highlighted circBACH1 as the most connected circRNA in the predicted ceRNA network and proposed it as a potential biomarker and regulator of endometrial receptivity.	0.4032
31257480	Molecular medicine reports	2019	Circular RNA sequencing reveals the molecular mechanism of the effects of acupuncture and moxibustion on endometrial receptivity in patients undergoing infertility treatment.		circ-LPAR1	hsa_circ_LPAR1	LPAR1	infertility	MONDO:0005047	infertility disorder	up-regulated	RT-qPCR; RNA-seq	"circ-LPAR1 was significantly upregulated in endometrial samples from infertile patients receiving acupuncture and moxibustion. It was included in a predicted circRNA-miR-mRNA network, suggesting possible involvement in ceRNA-mediated regulation of endometrial receptivity."	0.4032
31257480	Molecular medicine reports	2019	Circular RNA sequencing reveals the molecular mechanism of the effects of acupuncture and moxibustion on endometrial receptivity in patients undergoing infertility treatment.		circ-RSF1	hsa_circ_RSF1	RSF1	infertility	MONDO:0005047	infertility disorder	up-regulated	RT-qPCR; RNA-seq	circ-RSF1 was validated by RT-qPCR as significantly upregulated in endometrial samples from infertile patients treated with acupuncture and moxibustion. The study did not provide a circ-RSF1-specific regulatory axis or functional experiment beyond expression validation.	0.4032
31257480	Molecular medicine reports	2019	Circular RNA sequencing reveals the molecular mechanism of the effects of acupuncture and moxibustion on endometrial receptivity in patients undergoing infertility treatment.		circ-MLH3	hsa_circ_MLH3	MLH3	infertility	MONDO:0005047	infertility disorder	down-regulated	RT-qPCR; RNA-seq	circ-MLH3 was validated by RT-qPCR as significantly downregulated in endometrial samples from infertile patients treated with acupuncture and moxibustion. The study did not report a circ-MLH3-specific miRNA/mRNA axis or functional assay beyond expression validation.	0.4032
31298312	European review for medical and pharmacological sciences	2019	Circular RNA circ-SMAD7 promoted ovarian cancer cell proliferation and metastasis by suppressing KLF6.		circ-SMAD7 / circRNA SMAD7	hsa_circ_SMAD7	SMAD7	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circ-SMAD7 is up-regulated in ovarian cancer tissues and cell lines. Functional knockdown experiments indicate that it promotes ovarian cancer cell proliferation, migration and invasion, potentially through suppressing KLF6 expression. The study suggests circ-SMAD7 may serve as a therapeutic candidate target in ovarian cancer."	0.5751
31298383	European review for medical and pharmacological sciences	2019	CircRNA_069718 promotes cell proliferation and invasion in triple-negative breast cancer by activating Wnt/beta-catenin pathway.	hsa_circ_0069718				triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"CircRNA_069718 is up-regulated in TNBC tissues and breast cancer cell lines, and high expression is associated with lymph node metastasis, advanced TNM stage, and poor overall survival. Functionally, circRNA_069718 promotes breast cancer cell proliferation, invasion, cell cycle progression, and EMT-related changes. Mechanistically, it promotes TNBC progression through activation of the Wnt/beta-catenin pathway."	0.6584
31378036	Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology	2019	"[Effect of circular RNA hsa_circ_0063772 on proliferation, migration and invasion of oral squamous cell carcinoma cells]."	hsa_circ_0063772				oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR	"hsa_circ_0063772 is down-regulated in OSCC tissues and OSCC cell lines. Functional overexpression experiments show that hsa_circ_0063772 suppresses OSCC cell proliferation, migration and invasion, and reduces xenograft tumor growth, accompanied by decreased Bcl-2, Ki-67 and MMP-9 protein expression."	0.6278
31396323	American journal of translational research	2019	CircRNA LRP6 promotes the development of osteosarcoma via negatively regulating KLF2 and APC levels.		circLRP6 / CircRNA LRP6	hsa_circ_LRP6	LRP6	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"CircLRP6 is up-regulated in osteosarcoma tissues and cell lines and high expression predicts poor survival. Functionally, circLRP6 promotes OS cell proliferation, migration, invasion and cell cycle progression while inhibiting apoptosis. Mechanistically, it binds LSD1 and EZH2 to suppress tumor-suppressor genes KLF2 and APC, contributing to OS development."	0.7923
31486496	European review for medical and pharmacological sciences	2019	CircRNA_100876 promote proliferation and metastasis of breast cancer cells through adsorbing microRNA-361-3p in a sponge form.		circRNA_100876			breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circRNA_100876 is up-regulated in breast cancer tissues and cell lines, with higher levels in patients with distant metastasis. High circRNA_100876 expression predicts poor prognosis, and functional experiments indicate that it promotes breast cancer cell proliferation, invasion, migration and metastasis. Mechanistically, circRNA_100876 acts as a sponge for microRNA-361-3p and regulates microRNA-361-3p expression."	0.7078
31497198	American journal of translational research	2019	CircPOMT1 and circMCM3AP inhibit osteogenic differentiation of human adipose-derived stem cells by targeting miR-6881-3p.		circPOMT1	hsa_circ_POMT1	POMT1	bone defects	MONDO:0005497	bone development disease	down-regulated	RT-qPCR; RNA-seq	"circPOMT1 is downregulated during osteogenic differentiation of hASCs and appears to restrain osteogenesis. Its knockdown enhances osteogenic markers and mineralization, while mechanistically it is proposed to act through hsa-miR-6881-3p and the BMPs signaling pathway involving predicted targets Smad6 and Chordin. The study suggests circPOMT1 may be a potential target for bone defect repair."	0.5202
31497198	American journal of translational research	2019	CircPOMT1 and circMCM3AP inhibit osteogenic differentiation of human adipose-derived stem cells by targeting miR-6881-3p.		circMCM3AP	hsa_circ_MCM3AP	MCM3AP	bone defects	MONDO:0005497	bone development disease	down-regulated	RT-qPCR; RNA-seq	"circMCM3AP is downregulated during osteogenic differentiation of hASCs and appears to restrain osteogenesis. Its knockdown enhances osteogenic markers and mineralization, while mechanistically it is proposed to act through hsa-miR-6881-3p and the BMPs signaling pathway involving predicted targets Smad6 and Chordin. The study suggests circMCM3AP may be a potential target for bone defect repair."	0.5202
31497210	American journal of translational research	2019	Circ_0039569 promotes renal cell carcinoma growth and metastasis by regulating miR-34a-5p/CCL22.	hsa_circ_0039569	circ_0039569			renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0039569 is up-regulated in RCC tissues and cell lines and is associated with metastasis and advanced tumor staging. Functionally, circ_0039569 promotes RCC cell proliferation, migration, invasion and metastasis. Mechanistically, it acts through a circ_0039569/miR-34a-5p/CCL22 regulatory axis, suggesting an oncogenic role and potential biomarker value in RCC."	0.7421
31497351	American journal of cancer research	2019	Circular RNA circ-ADD3 inhibits hepatocellular carcinoma metastasis through facilitating EZH2 degradation via CDK1-mediated ubiquitination.	hsa_circ_0020007	circ-ADD3	hsa_circ_ADD3	ADD3	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"circ-ADD3 is a down-regulated human circRNA derived from ADD3 exons 4-12 in HCC tissues, cells and plasma. It suppresses HCC migration, invasion and metastasis by binding EZH2 and CDK1, facilitating CDK1-mediated EZH2 phosphorylation, ubiquitination and degradation, thereby reducing H3K27me3-mediated repression of anti-metastatic genes. Clinically, reduced circ-ADD3 is associated with metastatic features and worse survival, while plasma circ-ADD3 has diagnostic potential for HCC."	0.8807
31539115	European review for medical and pharmacological sciences	2019	CircRNA UBAP2 promotes the progression of ovarian cancer by sponging microRNA-144.		circular RNA UBAP2 / circUBAP2	hsa_circ_UBAP2	UBAP2	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circUBAP2 is up-regulated in ovarian cancer tissues and cell lines and is associated with advanced stage and poorer five-year survival. It mainly localizes to the cytoplasm and promotes OC cell proliferation and migration by sponging microRNA-144, thereby affecting the microRNA-144/CDH2 regulatory pathway. The study suggests circUBAP2 may serve as a diagnostic and therapeutic marker for OC."	0.7942
31599409	European review for medical and pharmacological sciences	2019	Circular circ_0000885 promotes hepatocellular carcinoma proliferation by epigenetically upregulating Caprin1.	hsa_circ_0000885	circ_0000885			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0000885 is up-regulated in HCC tissues and HCC cell lines. Its high expression is associated with lymphatic metastasis and advanced TNM stage, and functional knockdown experiments indicate that it promotes HCC cell proliferation and cell-cycle progression, at least partly by upregulating Caprin1."	0.5414
31599413	European review for medical and pharmacological sciences	2019	Upregulation of circHIPK3 promotes the progression of gastric cancer via Wnt/beta-catenin pathway and indicates a poor prognosis.		circular RNA HIPK3 / circHIPK3	hsa_circ_HIPK3	HIPK3	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circHIPK3 is upregulated in gastric cancer tissues and cell lines, and high expression is associated with shorter overall survival. Functionally, circHIPK3 promotes proliferation and migration of GC cells, at least partly by activating the Wnt/beta-catenin pathway and regulating WNT1, TCF4 and beta-catenin."	0.6568
31638250	Oncology reports	2019	Upregulation of circular RNA circ_FAM53B predicts adverse prognosis and accelerates the progression of ovarian cancer via the miR_646/VAMP2 and miR_647/MDM2 signaling pathways.	hsa_circ_0000267	circ-FAM53B	hsa_circ_FAM53B	FAM53B	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circ-FAM53B is upregulated in ovarian cancer tissues and cell lines and is associated with clinical severity and poor prognosis. Functionally, it promotes proliferation, migration and invasion while suppressing apoptosis in OC cells. Mechanistically, cytoplasmic circ-FAM53B acts as a ceRNA for miR-646 and miR-647, increasing VAMP2 and MDM2 expression to drive OC progression."	0.7628
31646575	European review for medical and pharmacological sciences	2019	Circular RNA circ_0067934 functions as an oncogene in glioma by targeting CSF1.	hsa_circ_0067934	circ_0067934			glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ_0067934 is up-regulated in human glioma tissues and glioma cell lines. Knockdown experiments indicate that it promotes glioma cell migration, invasion, and in vivo metastasis, likely through upregulating CSF1 expression. The study suggests circ_0067934 may act as an oncogenic circRNA and a potential therapeutic target in glioma."	0.5732
31646606	European review for medical and pharmacological sciences	2019	Characterization of hsa_circ_0000594 as a new biomarker and therapeutic target for hepatoblastoma.	hsa_circ_0000594		hsa_circ_TTBK2	TTBK2	hepatoblastoma / HB	MONDO:0018666	hepatoblastoma	up-regulated	RT-qPCR; ISH	"hsa_circ_0000594 is upregulated in hepatoblastoma tissues and may serve as a diagnostic/prognostic biomarker and therapeutic target. Functionally, it supports HB malignant phenotypes by promoting proliferation, viability, migration/invasion and reducing apoptosis. Mechanistically, it acts through a hsa_circ_0000594/miR-217/SIRT1 regulatory axis."	0.6829
31686520	Neoplasma	2020	Upregulated circZMIZ1 promotes the proliferation of prostate cancer cells and is a valuable marker in plasma.	hsa_circ_0005844	circZMIZ1	hsa_circ_ZMIZ1	ZMIZ1	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circZMIZ1 is upregulated in plasma from prostate cancer patients and in prostate cancer cell lines. The study supports an oncogenic role in prostate cancer by promoting cell proliferation and cell cycle progression, and suggests that circZMIZ1 modulates AR and AR-V7 expression in the androgen receptor signaling context. circZMIZ1 may serve as a diagnostic serum biomarker and potential therapeutic target for prostate cancer."	0.741
31693489	Endocrine-related cancer	2020	circ_0005273 promotes thyroid carcinoma progression by SOX2 expression.	hsa_circ_0005273	circ_0005273			papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0005273 is up-regulated in PTC tissues and cell lines and high expression is associated with poor overall survival. It promotes PTC cell proliferation, migration, invasion and xenograft tumor growth by acting as a miR-1183 sponge to regulate SOX2 expression, suggesting potential biomarker and therapeutic-target value."	0.8554
31696463	European review for medical and pharmacological sciences	2019	Circular RNA circRNA_0000285 promotes cervical cancer development by regulating FUS.		circRNA_0000285			cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circRNA_0000285 is up-regulated in cervical cancer tissues and cell lines. Functional knockdown experiments indicate that it promotes CC cell proliferation, migration, invasion, tumor formation and metastasis. Mechanistically, the study links circRNA_0000285 to up-regulation of FUS, suggesting a circRNA_0000285/FUS oncogenic mechanism and potential therapeutic value."	0.5434
31700878	Annals of translational medicine	2019	Comprehensive circular RNA profiling identifies CircFAM120A as a new biomarker of hypoxic lung adenocarcinoma.	hsa_circ_0008193	circFAM120A	hsa_circ_FAM120A	FAM120A	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; RNA-seq	"CircFAM120A is a human FAM120A-derived circRNA that is significantly downregulated in hypoxic A549 lung adenocarcinoma cells and lymph node-positive lung adenocarcinoma tissues. The study proposes CircFAM120A as a potential biomarker of lung adenocarcinoma hypoxia and metastatic risk, with predicted circRNA-miRNA-mRNA regulatory effects on signal transduction and cancer-related pathways."	0.6333
31702512	Current cancer drug targets	2020	circEPSTI1 Acts as a ceRNA to Regulate the Progression of Osteosarcoma.		circEPSTI1	hsa_circ_EPSTI1	EPSTI1	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circEPSTI1 is upregulated in osteosarcoma and promotes malignant progression, including proliferation, migration, invasion, tumor growth and lung metastasis. Mechanistically, circEPSTI1 functions as a ceRNA by sponging miR-892b to regulate MCL1 expression, suggesting potential value as a therapeutic target and biomarker."	0.7302
31721499	Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology	2019	"[Effect of circular RNA hsa_circ_0002203 on the proliferation, migration, invasion, and apoptosis of oral squamous cell carcinoma cells]."	hsa_circ_0002203			CAMTA1	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR	"hsa_circ_0002203 is down-regulated in OSCC and acts as a tumor suppressor. Overexpression inhibits proliferation, migration, invasion, and tumor formation while promoting apoptosis, with associated changes in BAX, Bcl-2, CyclinD1, and MMP-9."	0.5301
31738400	"Clinical science (London, England : 1979)"	2019	A novel circFMN2 promotes tumor proliferation in CRC by regulating the miR-1182/hTERT signaling pathways.	hsa_circ_0005100	circFMN2	hsa_circ_FMN2	FMN2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circFMN2 is an up-regulated oncogenic circRNA in CRC tissues, cell lines and serum exosomes. It promotes CRC proliferation, cell cycle progression, migration and xenograft tumor growth mainly by sponging miR-1182 and increasing hTERT expression, and it may serve as a biomarker and therapeutic target."	0.8571
31738400	"Clinical science (London, England : 1979)"	2019	A novel circFMN2 promotes tumor proliferation in CRC by regulating the miR-1182/hTERT signaling pathways.	hsa_circ_0001821				colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	hsa circ 0001821 was identified as one of the most up-regulated circRNAs in CRC tissues and its increased expression was validated by qRT-PCR in paired clinical samples. No functional or mechanistic experiments were reported for this circRNA.	0.3588
31738400	"Clinical science (London, England : 1979)"	2019	A novel circFMN2 promotes tumor proliferation in CRC by regulating the miR-1182/hTERT signaling pathways.	hsa_circ_0084188				colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	hsa circ 0084188 was identified as one of the most up-regulated circRNAs in CRC tissues and its increased expression was validated by qRT-PCR in paired clinical samples. No functional or mechanistic experiments were reported for this circRNA.	0.3588
31738400	"Clinical science (London, England : 1979)"	2019	A novel circFMN2 promotes tumor proliferation in CRC by regulating the miR-1182/hTERT signaling pathways.	hsa_circ_0001178				colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	hsa circ 0001178 was identified as one of the most up-regulated circRNAs in CRC tissues and its increased expression was validated by qRT-PCR in paired clinical samples. No functional or mechanistic experiments were reported for this circRNA.	0.3588
31757227	Oncology research	2019	"Circ_0071662, a novel tumor biomarker, suppresses bladder cancer cell proliferation and invasion by sponging miR-146b-3p."	hsa_circ_0071662	circ_0071662	hsa_circ_TPPP		bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"circ_0071662 is downregulated in human bladder cancer tissues and cell lines, and low expression is associated with advanced clinicopathological features and poorer survival. Functionally, circ_0071662 suppresses bladder cancer cell proliferation and invasion by sponging miR-146b-3p/miR-146-3p, upregulating HPGD and NF2, and reducing AKT signaling activation. The study proposes circ_0071662 as a prognostic biomarker and potential therapeutic target in bladder cancer."	0.7588
31773676	European review for medical and pharmacological sciences	2019	Identification of non-coding RNA regulatory networks in pediatric acute myeloid leukemia reveals circ-0004136 could promote cell proliferation by sponging miR-142.	hsa_circ_0004136	circ-0004136			pediatric acute myeloid leukemia / pediatric AML	MONDO:0004996	childhood acute myeloid leukemia	up-regulated	RT-qPCR; Microarray	"circ-0004136 is significantly upregulated in pediatric AML bone marrow samples and OCI-AML3 cells. The study indicates that circ-0004136 promotes AML cell proliferation mainly by sponging miR-142, and it may serve as a diagnostic biomarker candidate for pediatric AML."	0.7291
31773680	European review for medical and pharmacological sciences	2019	Circular RNA circ-PRKCI promotes cell proliferation and invasion by binding to microRNA-545 in gastric cancer.	hsa_circ_0067934	circ-PRKCI / circ_0067934	hsa_circ_PRKCI	PRKCI	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ-PRKCI (hsa_circ_0067934) is up-regulated in gastric cancer tissues and cell lines. Its high expression predicts poor prognosis and is associated with TNM stage and metastasis. Functionally, circ-PRKCI promotes GC cell proliferation and invasion while inhibiting apoptosis, mainly by binding/sponging microRNA-545."	0.7617
31773689	European review for medical and pharmacological sciences	2019	Circ-ZNF609 promotes carcinogenesis of gastric cancer cells by inhibiting miRNA-145-5p expression.	hsa_circ_0000615	Circ-ZNF609 / circular RNA ZNF609	hsa_circ_ZNF609	ZNF609	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"Circ-ZNF609 is up-regulated in gastric cancer tissues and cell lines. It promotes gastric cancer cell proliferation, invasion and metastasis while suppressing apoptosis, at least partly by binding to and inhibiting miRNA-145-5p through a ceRNA mechanism."	0.7164
31773699	European review for medical and pharmacological sciences	2019	Circ_0000064 adsorption of microRNA-143 promotes malignant progression of hepatocellular carcinoma.	hsa_circ_0000064	circ_0000064			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0000064 is up-regulated in hepatocellular carcinoma tissues and cell lines. High circ_0000064 expression is associated with advanced pathological stage and poor prognosis, and functionally it promotes HCC cell proliferation while inhibiting apoptosis. Mechanistically, circ_0000064 interacts with and suppresses microRNA-143."	0.7078
31773702	European review for medical and pharmacological sciences	2019	Circular RNA circ_0067934 functions as an oncogene in breast cancer by targeting Mcl-1.	hsa_circ_0067934	circ_0067934			breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"In this study, circ_0067934 was up-regulated in breast cancer tissues and cell lines. Knockdown experiments indicated that circ_0067934 promotes breast cancer cell viability, colony formation, proliferation, and cell cycle progression, at least partly by upregulating MCL-1. The paper also suggests circ_0067934 may be a promising marker for breast cancer."	0.5751
31777254	Neoplasma	2020	Identification of urinary hsa_circ _0137439 as potential biomarker and tumor regulator of bladder cancer.	hsa_circ_0137439		hsa_circ_MTDH	MTDH	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0137439 is up-regulated in urinary cell-free samples from bladder cancer patients and has diagnostic and prognostic biomarker potential. Functionally, it promotes proliferation, cell-cycle progression, migration and metastasis-like behavior of bladder cancer cells. Mechanistically, it acts mainly in the cytoplasm as a ceRNA that sponges miR-142-5p and regulates MTDH expression."	0.8323
31788127	Oncology letters	2019	hsa_circRNA_100873 upregulation is associated with increased lymphatic metastasis of esophageal squamous cell carcinoma.		hsa_circRNA_100873 / circRNA_100873	hsa_circ_PPFIA1	PPFIA1	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_100873 was identified by microarray and validated by RT-qPCR as upregulated in ESCC tissues, especially in the low-invasive high-lymphatic metastasis group. The study suggests that hsa_circRNA_100873 may promote ESCC lymphatic metastasis and invasion through a predicted miRNA-sponge mechanism, particularly involving hsa-miR-663a, and may have potential diagnostic or therapeutic value."	0.5135
31799656	European review for medical and pharmacological sciences	2019	Circ-DB participates in the progression of gastric cancer by competitively binding microRNA-34a to regulate the expression of MET.		circ-DB			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"Circ-DB is up-regulated in gastric cancer tissues and cell lines. It mainly localizes to the cytoplasm, binds microRNA-34a, and regulates MET expression through the circ-DB-microRNA-34a-MET axis. Functionally, circ-DB promotes proliferative ability and migration of gastric cancer cells and is associated with larger tumor diameter."	0.6429
31799660	European review for medical and pharmacological sciences	2019	Circular RNA_LARP4 inhibits cell proliferation and invasion of nasopharyngeal carcinoma by repressing ROCK1.		circular RNA_LARP4	hsa_circ_LARP4	LARP4	Nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	down-regulated	RT-qPCR	"Circular RNA_LARP4 is down-regulated in NPC tissues and cell lines. Its overexpression suppresses NPC cell proliferation, cell cycle progression, migration and invasion in vitro, at least partly through downregulation of ROCK1. The study proposes circular RNA_LARP4 as a tumor-suppressive circRNA and a potential marker for NPC."	0.5761
31799673	European review for medical and pharmacological sciences	2019	Circular RNA circ-SMAD7 promoted glioma cell proliferation and metastasis by upregulating PCNA.		circ-SMAD7 / CircRNA SMAD7	hsa_circ_SMAD7	SMAD7	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ-SMAD7 is up-regulated in glioma tissues and glioma cell lines. Functional knockdown experiments indicate that circ-SMAD7 promotes glioma cell proliferation, cell-cycle progression, migration, and invasion, likely through upregulating PCNA expression. Its expression is associated with WHO stage and KPS score, suggesting potential clinical relevance as a therapeutic target."	0.5414
31799682	European review for medical and pharmacological sciences	2019	CircHIPK3 aggravates myocardial ischemia-reperfusion injury by binding to miRNA-124-3p.		circHIPK3	hsa_circ_HIPK3	HIPK3	myocardial ischemia/reperfusion injury	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR	"This study found that circHIPK3 is up-regulated in an in vitro HCM cell model of myocardial I/R injury. CircHIPK3 aggravates myocardial I/R injury by binding to and inhibiting miRNA-124-3p, thereby suppressing cardiomyocyte proliferation and promoting apoptosis with altered Bax and Bcl-2 expression. The authors propose circHIPK3 as a potential therapeutic target for I/R injury."	0.5554
31814891	American journal of translational research	2019	Hypoxia-induced circular RNA has_circRNA_403658 promotes bladder cancer cell growth through activation of LDHA.		hsa_circRNA_403658 / cZNF292	hsa_circ_ZNF292	ZNF292	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"has-circRNA-403658/cZNF292 is a hypoxia-inducible circRNA derived from ZNF292 that is upregulated in bladder cancer tissues and hypoxic bladder cancer cells. It promotes bladder cancer growth, proliferation, invasion and aerobic glycolysis while inhibiting apoptosis, at least partly through interaction with and activation of LDHA. High expression is associated with poorer overall survival and adverse clinicopathological features, suggesting prognostic and therapeutic relevance."	0.8226
31818066	Zhonghua bing li xue za zhi = Chinese journal of pathology	2019	[Expression of circular RNA hsa_circ_0014130 in lung adenocarcinoma cell lines and its effect on proliferation and invasion of lung adenocarcinoma cell line].	hsa_circ_0014130				lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"This study found that hsa_circ_0014130 is up-regulated in several lung cancer cell lines and acts as an oncogenic circRNA in lung cancer cells. It promotes proliferation and invasion, likely through targeting hsa-miR-566 and enhancing TWIST1 expression in a TGF-beta/EMT-related context, and it is proposed as a potential therapeutic target."	0.4546
31829306	General physiology and biophysics	2019	circCDYL/microRNA-105-5p participates in modulating growth and migration of colon cancer cells.		circCDYL / Circular RNA CDYL	hsa_circ_CDYL	CDYL	colon cancer	MONDO:0021063	malignant colon neoplasm	down-regulated	RT-qPCR	"circCDYL was down-regulated in colon cancer tissues compared with adjacent tissues. Its overexpression inhibited colon cancer cell growth, migration and invasion, promoted apoptosis, and acted through repression of miR-150-5p with downstream blockade of PI3K/AKT and JAK/STAT signaling."	0.5434
31841184	European review for medical and pharmacological sciences	2019	Effect of circ MTHFD2 on resistance to pemetrexed in gastric cancer through regulating expression of miR-124.		circ MTHFD2 / hsa-circR0003936	hsa_circ_MTHFD2	MTHFD2	gastric cancer / GC	MONDO:0001056	gastric cancer	dysregulated	RT-qPCR; Microarray	"This study identified circ MTHFD2 as a dysregulated circRNA associated with pemetrexed/MTA resistance in gastric cancer MGC-803/MTA cells. Functionally, circ MTHFD2 promoted drug resistance and cell survival, at least partly by binding miR-124 and altering TS, ABCC11, and RCF1 protein expression. The authors propose circ MTHFD2 as a potential biomarker and therapeutic target for overcoming MTA resistance in gastric cancer."	0.5804
31841185	European review for medical and pharmacological sciences	2019	Circ_0001742 promotes tongue squamous cell carcinoma progression via miR-431-5p/ATF3 axis.	hsa_circ_0001742	circ_0001742			tongue squamous cell carcinoma / TSCC	MONDO:0000500	tongue squamous cell carcinoma	up-regulated	RT-qPCR	"circ_0001742 is up-regulated in TSCC tissues and cell lines. It promotes malignant phenotypes including proliferation, migration, invasion and EMT while inhibiting apoptosis, at least partly by acting as a ceRNA for miR-431-5p to increase ATF3 expression. The study suggests circ_0001742 as a potential therapeutic target for TSCC."	0.7277
31858530	European review for medical and pharmacological sciences	2019	Circ-0003998 promotes cell proliferative ability and invasiveness by binding to miR-197-3p in osteosarcoma.	hsa_circ_0003998	circ-0003998			osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ-0003998 is up-regulated in osteosarcoma tissues and cell lines, and high expression is associated with reduced overall survival. Functionally, circ-0003998 promotes osteosarcoma cell proliferation and invasion. Mechanistically, it binds miR-197-3p and up-regulates KLF10 expression, thereby accelerating osteosarcoma progression."	0.7113
31858548	European review for medical and pharmacological sciences	2019	Circular RNA hsa_circ_0000285 acts as an oncogene in laryngocarcinoma by inducing Wnt/beta-catenin signaling pathway.	hsa_circ_0000285				laryngeal carcinoma	MONDO:0002358	laryngeal carcinoma	up-regulated	RT-qPCR	"This study reports that hsa_circ_0000285 is up-regulated in laryngocarcinoma tissues and functions as an oncogenic circRNA. Functional assays indicate that hsa_circ_0000285 promotes laryngocarcinoma cell proliferation and inhibits apoptosis, likely through activation of the Wnt/beta-catenin signaling pathway and its target proteins Wnt3a, beta-catenin, C-myc, and Survivin."	0.5358
31858554	European review for medical and pharmacological sciences	2019	"Circular RNA circ_0067934 exhaustion expedites cell apoptosis and represses cell proliferation, migration and invasion in thyroid cancer via sponging miR-1304 and regulating CXCR1 expression."	hsa_circ_0067934	circ_0067934	hsa_circ_PRKCI	PRKCI	thyroid cancer / TC	MONDO:0002108	thyroid cancer	up-regulated	RT-qPCR	"circ_0067934 is up-regulated in thyroid cancer tissues and cells and is associated with advanced AJCC grade, lymph node metastasis, and poor prognosis. Functionally, circ_0067934 promotes TC cell proliferation, migration and invasion and suppresses apoptosis, while its knockdown inhibits xenograft tumor growth. Mechanistically, it acts as a sponge for miR-1304 to increase CXCR1 expression through a circ_0067934/miR-1304/CXCR1 axis."	0.817
31858556	European review for medical and pharmacological sciences	2019	"Circ-0001801 contributes to cell proliferation, migration, invasion and epithelial to mesenchymal transition (EMT) in glioblastoma by regulating miR-628-5p/HMGB3 axis."	hsa_circ_0001801	circ-0001801 / circPCMTD1	hsa_circ_PCMTD1	PCMTD1	Glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR	"circ-0001801/circPCMTD1 is up-regulated in GBM tumors and cell lines. It promotes GBM cell proliferation, migration, invasion and EMT by sponging miR-628-5p and increasing HMGB3 expression, suggesting potential value as a biomarker and therapeutic target."	0.7372
31858557	European review for medical and pharmacological sciences	2019	Circular RNA TTBK2_promotes the development of human glioma cells via miR-520b/EZH2 axis.		circ-TTBK2 / Tau tubulin kinase 2 circular RNAs	hsa_circ_TTBK2	TTBK2	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"This study identifies circ-TTBK2 as an up-regulated oncogenic circRNA in human glioma tissues and cell lines. circ-TTBK2 promotes glioma cell proliferation, invasion, and in vivo tumor growth while suppressing apoptosis, mainly through sponging miR-520b and regulating EZH2 in the circ-TTBK2/miR-520b/EZH2 axis. The axis is proposed as a potential target for glioma diagnosis and therapy."	0.6536
31858560	European review for medical and pharmacological sciences	2019	CircRNA_0016418 expedites the progression of human skin melanoma via miR-625/YY1 axis.	hsa_circ_0016418	circRNA_0016418	hsa_circ_VASH2	VASH2	melanoma	MONDO:0005012	cutaneous melanoma	up-regulated	RT-qPCR	"Circ0016418 is up-regulated in human skin melanoma tissues and SKMEL1/SKMEL5 cells. It promotes proliferation, migration, invasion, and EMT by acting as a ceRNA for miR-625 and increasing YY1 expression, suggesting a potential therapeutic indicator role in skin melanoma."	0.7129
31875589	Endocrine journal	2020	Circular RNA HIPK3 contributes to hyperglycemia and insulin homeostasis by sponging miR-192-5p and upregulating transcription factor forkhead box O1.		circular RNA HIPK3 / circHIPK3	hsa_circ_HIPK3	HIPK3	diabetes	MONDO:0005015	diabetes mellitus	up-regulated	RT-qPCR	"This study shows that oleate induces circHIPK3 expression in HepG2 cells and that circHIPK3 promotes lipid accumulation, triglyceride content, cellular glucose production, and gluconeogenic gene expression. Mechanistically, circHIPK3 sponges miR-192-5p to relieve repression of FOXO1, forming a circHIPK3-miR-192-5p-FOXO1 axis involved in hyperglycemia and insulin resistance."	0.6207
31884800	Neoplasma	2020	The potential of ciRS-7 for predicting onset and prognosis of cervical cancer.		ciRS-7 / cerebellar degeneration-associated protein 1 antisense transcript			cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"This study found that ciRS-7 is up-regulated in cervical cancer and CIN compared with healthy controls, and is abundantly expressed in cervical cancer tissues versus adjacent non-tumor tissues. High ciRS-7 expression is associated with poor prognosis and aggressive clinical features, and ciRS-7 overexpression promotes cervical cancer cell proliferation, viability, migration, invasion and EMT while inhibiting apoptosis. The study supports ciRS-7 as a potential diagnostic and prognostic biomarker for cervical cancer."	0.6742
31930399	"Clinical science (London, England : 1979)"	2020	Transcriptome sequencing of circular RNA reveals a novel circular RNA-has_circ_0114427 in the regulation of inflammation in acute kidney injury.	hsa_circ_0114427		hsa_circ_ZNF644	ZNF644	acute kidney injury / AKI	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR; RNA-seq	"This study identified human circ-0114427 as up-regulated in early AKI cell models after selection from cisplatin-induced mouse AKI circRNA sequencing and homologous gene screening. Mechanistically, circ-0114427 functions as a miR-494 sponge to increase ATF3 expression, thereby suppressing NF-kappaB-related inflammatory cytokines such as IL-6 and resisting early inflammatory injury in AKI."	0.6419
31933802	International journal of clinical and experimental pathology	2019	Hsa_circ_0057481 promotes laryngeal cancer proliferation and migration by modulating the miR-200c/ZEB1 axis.	hsa_circ_0057481				laryngeal carcinoma	MONDO:0002358	laryngeal carcinoma	up-regulated	RT-qPCR	"hsa_circ_0057481 is up-regulated in laryngeal cancer tissues and functions as an oncogenic circRNA. Its knockdown suppresses proliferation, colony formation, cell cycle progression, invasion, migration, and xenograft tumor growth while promoting apoptosis. Mechanistically, it sponges miR-200c and regulates the miR-200c/ZEB1 axis, suggesting potential therapeutic relevance."	0.7375
31933904	International journal of clinical and experimental pathology	2019	"Circular RNA DLGAP4 is down-regulated and negatively correlates with severity, inflammatory cytokine expression and pro-inflammatory gene miR-143 expression in acute ischemic stroke patients."		circular RNA DLGAP4 / circ-DLGAP4	hsa_circ_DLGAP4	DLGAP4	ischemic stroke / IS	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR	"This clinical case-control study found that PBMC circ-DLGAP4 is down-regulated in acute ischemic stroke patients. Lower circ-DLGAP4 expression is associated with higher AIS severity and inflammatory markers, while circ-DLGAP4 shows diagnostic potential for distinguishing AIS patients from controls. The study also reports a negative correlation between circ-DLGAP4 and miR-143, suggesting a possible circ-DLGAP4/miR-143-related inflammatory mechanism."	0.6028
31934131	International journal of clinical and experimental pathology	2019	Detection of serum long non-coding RNA UCA1 and circular RNAs for the diagnosis of bladder cancer and prediction of recurrence.	hsa_circ_0000896	circFARSA	hsa_circ_FARSA	FARSA	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"Serum circFARSA was up-regulated in bladder cancer patients and also higher in recurrent BC than in non-recurrent patients. The study suggests circFARSA, particularly combined with circBANP, may serve as a noninvasive prognostic biomarker for BC recurrence, with predicted miRNA-sponge activity toward miR-382-5p."	0.459
31934131	International journal of clinical and experimental pathology	2019	Detection of serum long non-coding RNA UCA1 and circular RNAs for the diagnosis of bladder cancer and prediction of recurrence.	hsa_circ_0000936	circSHKBP1	hsa_circ_SHKBP1	SHKBP1	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"Serum circSHKBP1 was up-regulated in bladder cancer and recurrent BC. Its combination with lncRNA UCA1 showed diagnostic value for distinguishing BC patients from controls, and circSHKBP1 was predicted to act as an endogenous sponge for miR-635."	0.459
31934131	International journal of clinical and experimental pathology	2019	Detection of serum long non-coding RNA UCA1 and circular RNAs for the diagnosis of bladder cancer and prediction of recurrence.	hsa_circ_0040823	circBANP	hsa_circ_BANP	BANP	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"Although circBANP was not significantly different between BC patients and healthy controls, it was up-regulated in recurrent BC compared with non-recurrent patients. The study proposes serum circBANP, especially combined with circFARSA, as a prognostic biomarker for recurrence, with predicted miRNA-sponge activity toward miR-516b-5p."	0.459
31938119	International journal of clinical and experimental pathology	2018	Overexpression of circRNA-001175 promotes proliferation and angiogenesis and inhibits apoptosis of the human umbilical vein endothelial cells (HUVECs) induced by high glucose.		circRNA-001175			high glucose stress	MONDO:0004995	cardiovascular disorder	down-regulated	RT-qPCR	"CircRNA-001175 is down-regulated in HUVECs under high glucose treatment. Its overexpression protects endothelial cells from high glucose-induced injury by promoting viability/proliferation and tubule formation while suppressing apoptosis, suggesting potential relevance to high glucose-associated vascular dysfunction."	0.421
31938144	International journal of clinical and experimental pathology	2018	Circulating circular RNAs hsa_circ_0001204 and hsa_circ_0001747 act as diagnostic biomarkers for active tuberculosis detection.	hsa_circ_0001204				active tuberculosis	MONDO:0100481	active tuberculosis	down-regulated	RT-qPCR	"hsa_circ_0001204 is a human circulating circRNA whose plasma level is significantly reduced in active pulmonary TB. It is associated with radiological disease severity, has diagnostic value for distinguishing TB from healthy and disease controls, returns toward normal after successful treatment, and has predicted interactions with several miRNAs."	0.459
31938144	International journal of clinical and experimental pathology	2018	Circulating circular RNAs hsa_circ_0001204 and hsa_circ_0001747 act as diagnostic biomarkers for active tuberculosis detection.	hsa_circ_0001747				active tuberculosis	MONDO:0100481	active tuberculosis	down-regulated	RT-qPCR	"hsa_circ_0001747 is a human circulating circRNA whose plasma level is significantly reduced in active pulmonary TB. It is associated with radiological disease severity, has diagnostic value for distinguishing TB from healthy and disease controls, returns toward normal after successful treatment, and has predicted interactions with several miRNAs."	0.459
31938236	International journal of clinical and experimental pathology	2018	Hsa_circ_0007534 as a blood-based marker for the diagnosis of colorectal cancer and its prognostic value.	hsa_circ_0007534		hsa_circ_DDX42	DDX42	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"This study reports that hsa_circ_0007534 is up-regulated in colorectal cancer tumor tissues and plasma. Plasma hsa_circ_0007534 has diagnostic value for CRC and its high expression is associated with advanced clinical features, metastasis-related phenotype, poor differentiation, and poorer overall survival."	0.5918
31949766	International journal of clinical and experimental pathology	2018	Circ-PAX2 promotes proliferation and metastasis by absorbing miR-186 in lung cancer cells.	hsa_circ_0092400	circ-PAX2	hsa_circ_PAX2	PAX2	lung squamous cell carcinoma / LSCC	MONDO:0005097	squamous cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0092400/circ-PAX2 is up-regulated in LSCC tissues and lung cancer cell lines. It promotes lung cancer proliferation, invasion/migration, metastasis, and xenograft tumor growth while inhibiting apoptosis. Mechanistically, circ-PAX2 functions as a miR-186 sponge/absorber and may regulate PAX2 mRNA expression and translation, suggesting potential value as an LSCC detection marker and therapeutic target."	0.6829
31949813	International journal of clinical and experimental pathology	2018	"CircRNA circFNDC3B promotes esophageal cancer progression via cell proliferation, apoptosis, and migration regulation."	hsa_circ_0001361	circFNDC3B	hsa_circ_FNDC3B	FNDC3B	esophageal cancer	MONDO:0007576	esophageal cancer	up-regulated	RT-qPCR	"circFNDC3B, a circRNA generated from FNDC3B exons, is up-regulated in esophageal cancer tissues. Functional silencing experiments in ECA109 and KYSE150 cells indicate that circFNDC3B promotes proliferation, migration, and invasion while suppressing apoptosis, supporting a pro-progression role in esophageal cancer."	0.7039
31949836	International journal of clinical and experimental pathology	2018	Hsa_circ_0102533 serves as a blood-based biomarker for non-small-cell lung cancer diagnosis and regulates apoptosis in vitro.	hsa_circ_0102533		hsa_circ_PCNX	PCNX	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"Hsa_circ_0102533 is up-regulated in NSCLC tumor tissues, whole blood, and NSCLC cell lines. It promotes NSCLC cell proliferation and suppresses apoptosis in vitro, and its blood expression shows diagnostic potential, especially for early-stage NSCLC."	0.7472
31957821	European review for medical and pharmacological sciences	2020	"Cyclic RNA hsa_circ_0091017 inhibits proliferation, migration and invasiveness of bladder cancer cells by binding to microRNA-589-5p."	hsa_circ_0091017		hsa_circ_TAF1	TAF1	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR	"hsa_circ_0091017 is down-regulated in bladder cancer tissues and cell lines. Its overexpression suppresses bladder cancer cell proliferation, migration and invasion, at least partly through binding to and negatively regulating microRNA-589-5p."	0.6479
31957828	European review for medical and pharmacological sciences	2020	"Circular RNA hsa_circ_0006168 contributes to cell proliferation, migration and invasion in esophageal cancer by regulating miR-384/RBBP7 axis via activation of S6K/S6 pathway."	hsa_circ_0006168	circ_0006168			esophageal cancer	MONDO:0007576	esophageal cancer	up-regulated	RT-qPCR	"hsa_circ_0006168/circ_0006168 is up-regulated in esophageal cancer tumors and cell lines and is associated with more advanced clinical phase. Functionally, it promotes EC cell proliferation, migration, invasion, and glycolysis. Mechanistically, it sponges miR-384 to increase RBBP7 expression and activate the S6K/S6 pathway."	0.7372
31957839	European review for medical and pharmacological sciences	2020	Circ_0005075 stimulates the proliferation and metastasis of glioma via downregulating SIRT1.	hsa_circ_0005075	circ_0005075			glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ_0005075 is up-regulated in glioma tissues and glioma cell lines. High circ_0005075 expression is associated with lymphatic and distant metastasis and poor OS/PFS, while functional experiments indicate that circ_0005075 promotes glioma cell proliferation/viability and migration. Mechanistically, the study reports that circ_0005075 aggravates malignant glioma progression by negatively regulating SIRT1."	0.6806
31957851	European review for medical and pharmacological sciences	2020	CircRNA 010567 improves myocardial infarction rats through inhibiting TGF-beta1.		circRNA 010567			myocardial infarction / MI	MONDO:0005068	myocardial infarction	unknown	RT-qPCR	"This study investigated circRNA 010567 in a rat myocardial infarction model and found that circRNA 010567 siRNA improved cardiac function, reduced myocardial fibrosis, and inhibited myocardial apoptosis. Its proposed mechanism is suppression of the TGF-beta1 signaling pathway, reflected by reduced TGF-beta1 and Smad3 mRNA and protein levels in heart tissues."	0.3168
31966557	International journal of clinical and experimental pathology	2017	Hsa_circ_0101996 combined with hsa_circ_0101119 in peripheral whole blood can serve as the potential biomarkers for human cervical squamous cell carcinoma.	hsa_circ_0101996		hsa_circ_SOS2	SOS2	cervical squamous cell carcinoma / CSCC	MONDO:0006143	cervical squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0101996 is significantly up-regulated in peripheral whole blood from CSCC patients and shows diagnostic value for distinguishing CSCC from healthy controls. The study suggests that combining hsa_circ_0101996 with hsa_circ_0101119 improves diagnostic performance, while a MAPK-related mechanism is proposed but not experimentally validated."	0.5662
31966557	International journal of clinical and experimental pathology	2017	Hsa_circ_0101996 combined with hsa_circ_0101119 in peripheral whole blood can serve as the potential biomarkers for human cervical squamous cell carcinoma.	hsa_circ_0104649				cervical squamous cell carcinoma / CSCC	MONDO:0006143	cervical squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circ_0104649 is significantly up-regulated in peripheral whole blood from CSCC patients compared with healthy controls. The paper did not further evaluate its diagnostic ROC performance or molecular function.	0.4773
31966557	International journal of clinical and experimental pathology	2017	Hsa_circ_0101996 combined with hsa_circ_0101119 in peripheral whole blood can serve as the potential biomarkers for human cervical squamous cell carcinoma.	hsa_circ_0104443				cervical squamous cell carcinoma / CSCC	MONDO:0006143	cervical squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circ_0104443 is significantly up-regulated in peripheral whole blood from CSCC patients compared with healthy controls. The paper did not further evaluate its diagnostic ROC performance or molecular function.	0.4773
31966557	International journal of clinical and experimental pathology	2017	Hsa_circ_0101996 combined with hsa_circ_0101119 in peripheral whole blood can serve as the potential biomarkers for human cervical squamous cell carcinoma.	hsa_circ_0101119		hsa_circ_DOCK9	DOCK9	cervical squamous cell carcinoma / CSCC	MONDO:0006143	cervical squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0101119 is significantly up-regulated in peripheral whole blood from CSCC patients and shows diagnostic value for distinguishing CSCC from healthy controls. The study suggests that combining hsa_circ_0101119 with hsa_circ_0101996 improves diagnostic performance, while a MAPK-related mechanism is proposed but not experimentally validated."	0.5662
31966702	International journal of clinical and experimental pathology	2017	Expression of circular RNA circASXL1 correlates with TNM classification and predicts overall survival in bladder cancer.	hsa_circ_0001136	circASXL1	hsa_circ_ASXL1	ASXL1	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circASXL1 is a human circRNA transcribed from the ASXL1 gene locus and is significantly up-regulated in bladder cancer tissues. Its high expression correlates with tumor grade, TNM-related parameters, lymph node invasion, distant metastasis, and shorter overall survival, suggesting diagnostic and prognostic value in bladder cancer."	0.6759
31983112	Journal of B.U.ON. : official journal of the Balkan Union of Oncology	2019	CircRNA_0000502 promotes hepatocellular carcinoma metastasis and inhibits apoptosis through targeting microRNA-124.	hsa_circ_0000502	circ-0000502			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0000502 is up-regulated in HCC tissues and cell lines and its high expression is associated with poor prognosis. Functionally, circ_0000502 promotes HCC proliferation, invasion, migration and metastasis while inhibiting apoptosis. Mechanistically, it directly targets and negatively regulates miR-124, and miR-124 can counteract the effects of circ_0000502 in HCC cells."	0.7078
32051745	American journal of translational research	2020	Downregulated expression of hsa_circ_0037515 and hsa_circ_0037516 as novel biomarkers for non-small cell lung cancer.	hsa_circ_0037515		hsa_circ_ABCA3	ABCA3	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"hsa_circ_0037515 is derived from the ABCA3 locus and is significantly downregulated in NSCLC tissues and lung cancer cell lines. The study supports its potential diagnostic utility for NSCLC, with an individual ROC AUC of 0.81 and improved diagnostic performance when combined with hsa_circ_0037516."	0.6238
32051745	American journal of translational research	2020	Downregulated expression of hsa_circ_0037515 and hsa_circ_0037516 as novel biomarkers for non-small cell lung cancer.	hsa_circ_0037516		hsa_circ_ABCA3	ABCA3	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"hsa_circ_0037516 is derived from the ABCA3 locus and is significantly downregulated in NSCLC tissues and lung cancer cell lines. The study supports its potential diagnostic utility for NSCLC, with an individual ROC AUC of 0.82 and improved diagnostic performance when combined with hsa_circ_0037515."	0.6238
32051753	American journal of translational research	2020	Circ-0001313/miRNA-510-5p/AKT2 axis promotes the development and progression of colon cancer.	hsa_circ_0001313	circ-0001313			colon cancer	MONDO:0021063	malignant colon neoplasm	up-regulated	RT-qPCR; Microarray	"circ-0001313 is up-regulated in colon cancer tissues and cell lines and acts as an oncogenic circRNA. It promotes colon cancer cell proliferation and suppresses apoptosis through a ceRNA mechanism involving miR-510-5p and AKT2, with downstream effects on Bcl-2 family proteins and PI3K/AKT/mTOR signaling."	0.7759
32062910	Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi	2019	[Association between circular RNAs expression in serum and gastric cancer].	hsa_circ_0014717				gastric cancer / GC	MONDO:0001056	gastric cancer	dysregulated	RT-qPCR	hsa_circ_0014717 was evaluated in serum samples as a circRNA associated with gastric cancer. The study focused on its clinical diagnostic relevance rather than a mechanistic pathway.	0.4187
32062910	Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi	2019	[Association between circular RNAs expression in serum and gastric cancer].	hsa_circ_0001017				gastric cancer / GC	MONDO:0001056	gastric cancer	dysregulated	RT-qPCR	hsa_circ_0001017 was evaluated in serum samples as a circRNA associated with gastric cancer. The study focused on its clinical diagnostic relevance rather than a mechanistic pathway.	0.4187
32062910	Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi	2019	[Association between circular RNAs expression in serum and gastric cancer].	hsa_circ_0001895				gastric cancer / GC	MONDO:0001056	gastric cancer	dysregulated	RT-qPCR	hsa_circ_0001895 was evaluated in serum samples as a circRNA associated with gastric cancer. The study focused on its clinical diagnostic relevance rather than a mechanistic pathway.	0.4187
32096158	European review for medical and pharmacological sciences	2020	Circular RNA circ-ABCB10 promotes the proliferation and invasion of thyroid cancer by targeting KLF6.		circ-ABCB10	hsa_circ_ABCB10	ABCB10	thyroid cancer / TC	MONDO:0002108	thyroid cancer	up-regulated	RT-qPCR	"circ-ABCB10 is up-regulated in thyroid cancer tissues and thyroid cancer cell lines. Functional assays indicate that circ-ABCB10 promotes thyroid cancer cell proliferation and invasion in vitro, at least partly by targeting and negatively regulating KLF6. The study proposes the circ-ABCB10/KLF6 axis as a potential therapeutic target for thyroid cancer."	0.5732
32096163	European review for medical and pharmacological sciences	2020	Upregulation of circular SMAD7 inhibits tumorigenesis of gastric cancer by reversing epithelial-to-mesenchymal transition.			hsa_circ_SMAD7	SMAD7	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"Circ-SMAD7 is down-regulated in gastric cancer tissues and cell lines. Its upregulation suppresses GC migration, invasion, and in vivo metastasis, likely by reversing the EMT process through increased E-cadherin and decreased N-cadherin and Vimentin. The study suggests circ-SMAD7 may be a prospective therapeutic target for GC."	0.5414
32096170	European review for medical and pharmacological sciences	2020	Circular RNA hsa_circ_0010882 promotes the progression of gastric cancer via regulation of the PI3K/Akt/mTOR signaling pathway.	hsa_circ_0010882		hsa_circ_RPL11	RPL11	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"hsa_circ_0010882 is up-regulated in the plasma of gastric cancer patients and in gastric cancer cell lines. It promotes proliferation, migration and invasion, suppresses apoptosis, and appears to activate the PI3K/Akt/mTOR signaling pathway. Clinically, high hsa_circ_0010882 expression is associated with advanced disease features and poorer overall survival, suggesting prognostic value."	0.7396
32096173	European review for medical and pharmacological sciences	2020	Hsa_circ_0011946 promotes the migration and invasion of hepatocellular carcinoma by inducing EMT process.	hsa_circ_0011946				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"This study found that hsa_circ_0011946 is up-regulated in HCC tissues and cell lines. Functional knockdown experiments showed that hsa_circ_0011946 promotes HCC cell migration and invasion, likely by inducing EMT-related changes involving E-cadherin, N-cadherin and Vimentin. Clinically, high hsa_circ_0011946 expression was associated with lymphatic metastasis, suggesting potential value as a therapeutic target."	0.5358
32096177	European review for medical and pharmacological sciences	2020	Circular RNA hsa_circ_0017247 acts as an oncogene in bladder cancer by inducing Wnt/beta-catenin signaling pathway.	hsa_circ_0017247	circ_0017247			bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"hsa_circ_0017247 is up-regulated in BLCA tissues and functions as an oncogenic circRNA. Knockdown of hsa_circ_0017247 suppresses proliferation, colony formation, tumor growth and metastasis, promotes apoptosis, regulates cell cycle, and downregulates Wnt/beta-catenin pathway targets including Wnt3a, beta-catenin, C-myc and Survivin. The study proposes hsa_circ_0017247 as a potential biomarker and therapeutic target for BLCA."	0.5442
32115515	Biological & pharmaceutical bulletin	2020	circACTR2: A Novel Mechanism Regulating High Glucose-Induced Fibrosis in Renal Tubular Cells via Pyroptosis.	hsa_circ_0008529	hsa_circRNA_102747	hsa_circ_ACTR2	ACTR2	Diabetic nephropathy / DN	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR; Microarray	"This study identified hsa_circRNA_102747, named circACTR2, as an up-regulated circRNA in high-glucose-stressed human HK-2 renal proximal tubular cells, a DKD-related in vitro model. Functional knockdown experiments showed that circACTR2 promotes pyroptosis, IL-1beta release, inflammation, and fibrotic marker production, suggesting potential value as a therapeutic target or biomarker for DKD."	0.593
32124964	International journal of molecular medicine	2020	Expression and clinical significance of circular RNAs hsa_circ_0000175 and hsa_circ_0008410 in peripheral blood mononuclear cells from patients with rheumatoid arthritis.	hsa_circ_0000175		hsa_circ_ELK4	ELK4	rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	down-regulated	RT-qPCR	"hsa_circ_0000175 is significantly down-regulated in PBMCs from RA patients. Its expression correlates with RA-related immune and inflammatory clinical parameters, shows diagnostic utility, and is identified as a risk factor for RA. The study also predicts that hsa_circ_0000175 may interact with hsa-miR-608, hsa-miR-654-3p and hsa-miR-3652."	0.459
32124964	International journal of molecular medicine	2020	Expression and clinical significance of circular RNAs hsa_circ_0000175 and hsa_circ_0008410 in peripheral blood mononuclear cells from patients with rheumatoid arthritis.	hsa_circ_0008410		hsa_circ_PGS1	PGS1	rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"hsa_circ_0008410 is significantly up-regulated in PBMCs from RA patients. Its expression correlates with tender joint count, disease duration, platelet count and plateletcrit, shows diagnostic utility, and is identified as a risk factor for RA. The study also predicts that hsa_circ_0008410 may interact with hsa-miR-6776-3p, hsa-miR-412-3p and hsa-miR-4697-3p."	0.459
32141537	European review for medical and pharmacological sciences	2020	CircAGFG1 aggravates the progression of cervical cancer by downregulating p53.		circAGFG1	hsa_circ_AGFG1	AGFG1	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"CircAGFG1 is upregulated in cervical cancer tissues and cell lines and is associated with advanced malignant features and poor prognosis. Functionally, circAGFG1 promotes CC cell proliferation and disease progression by recruiting EZH2 to suppress p53 transcription."	0.7789
32141540	European review for medical and pharmacological sciences	2020	Circ_0009910 promotes proliferation and metastasis of hepatocellular carcinoma cells through miR-335-5p/ROCK1 axis.	hsa_circ_0009910	circ_0009910			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0009910 is up-regulated in hepatocellular carcinoma tissues and cell lines. It promotes HCC cell proliferation, migration, invasion, tumor growth and metastasis by targeting miR-335-5p and relieving miR-335-5p-mediated inhibition of ROCK1."	0.7126
32141541	European review for medical and pharmacological sciences	2020	Circular RNA circ-SMAD7 is downregulated in colorectal cancer and suppresses tumor metastasis by regulating epithelial mesenchymal transition.		circ-SMAD7 / circRNA SMAD7	hsa_circ_SMAD7	SMAD7	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"circ-SMAD7 is downregulated in colorectal cancer tissues and CRC cell lines. Higher circ-SMAD7 expression is associated with better overall survival, and functional assays indicate that circ-SMAD7 suppresses CRC cell migration and invasion by inhibiting EMT and regulating E-cadherin, N-cadherin, and Vimentin."	0.6527
32141542	European review for medical and pharmacological sciences	2020	CircDDX17 reduces 5-fluorouracil resistance and hinders tumorigenesis in colorectal cancer by regulating miR-31-5p/KANK1 axis.		circDDX17 / DEAD-box helicase 17 circRNA	hsa_circ_DDX17	DEAD-box helicase 17	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"circDDX17 is down-regulated in colorectal cancer tissues and cells. Its upregulation enhances 5-Fu sensitivity, promotes apoptosis, and suppresses invasion, EMT and tumor growth by sponging miR-31-5p and increasing KANK1 expression. The study suggests circDDX17 may be a therapeutic target for overcoming CRC chemoresistance."	0.6536
32141553	European review for medical and pharmacological sciences	2020	Circular RNA hsa_circ_0012673 facilitates lung cancer cell proliferation and invasion via miR-320a/LIMK18521 axis.	hsa_circ_0012673	circ_0012673			lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"Hsa_circ_0012673/circ_0012673 is up-regulated in lung cancer tissues and cell lines. It promotes lung cancer cell proliferation, migration, invasion and EMT while suppressing apoptosis, at least partly by sponging miR-320a and increasing LIMK1 expression. The study suggests circ_0012673 may be a therapeutic target for lung cancer."	0.6521
32141555	European review for medical and pharmacological sciences	2020	Circular RNA_LARP4 inhibits the progression of non-small-cell lung cancer by regulating the expression of SMAD7.		Circular RNA_LARP4 / Circ LARP4	hsa_circ_LARP4	LARP4	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"Circ LARP4 is down-regulated in NSCLC tissues and cell lines. Higher circ LARP4 expression is associated with better disease-free survival, and overexpression suppresses NSCLC cell migration, invasion, and metastasis-associated behavior by up-regulating SMAD7 expression."	0.6148
32141558	European review for medical and pharmacological sciences	2020	"Circular RNA hsa_circ_0008039 promotes proliferation, migration and invasion of breast cancer cells through upregulating CBX4 via sponging miR-515-5p."	hsa_circ_0008039				Breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"hsa_circ_0008039 is up-regulated in breast cancer tissues and cell lines. It promotes breast cancer cell proliferation, migration, invasion and xenograft tumor growth by acting as a ceRNA for miR-515-5p and increasing CBX4 expression, suggesting potential therapeutic relevance."	0.7277
32141562	European review for medical and pharmacological sciences	2020	Circular RNA circ_0017247 promotes melanoma migration and invasion via targeting miR-145.	hsa_circ_0017247	circ_0017247			melanoma	MONDO:0005105	melanoma	up-regulated	RT-qPCR	"circ_0017247 is up-regulated in melanoma tissues and melanoma cell lines. Functionally, circ_0017247 promotes melanoma cell migration, invasion, and in vivo metastasis, while its knockdown suppresses these phenotypes. Mechanistically, the study reports that circ_0017247 directly targets miR-145, suggesting a circ_0017247/miR-145 axis as a potential therapeutic target in melanoma."	0.6479
32196577	European review for medical and pharmacological sciences	2020	Circ PSMC3 inhibits prostate cancer cell proliferation by downregulating DGCR8.		Circ PSMC3 / Circular PSMC3	hsa_circ_PSMC3	PSMC3	prostate cancer / PCa	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR	"circPSMC3 is downregulated in prostate cancer tissues and cell lines, and low expression is associated with worse disease-free survival. Functionally, circPSMC3 acts as a tumor suppressor by inhibiting PCa cell proliferation, migration and invasion, regulating cell cycle arrest, and reducing xenograft tumor formation. Mechanistically, the study links circPSMC3 to DGCR8 downregulation and suggests circPSMC3 as a potential therapeutic target."	0.622
32196586	European review for medical and pharmacological sciences	2020	Circular RNA-ABCB10 suppresses hepatocellular carcinoma progression through upregulating NRP1/ABL2 via sponging miR-340-5p/miR-452-5p.	hsa_circ_0008717	Circular RNA-ABCB10 / circ-ABCB10	hsa_circ_ABCB10	ABCB10	Hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"In this study, circ-ABCB10 is downregulated in HCC tissues and cell lines and acts as an anti-oncogenic circRNA. Its overexpression suppresses proliferation, migration, invasion, colony formation and xenograft tumor growth while promoting apoptosis. Mechanistically, circ-ABCB10 sponges miR-340-5p and miR-452-5p to upregulate NRP1 and ABL2, suggesting a potential biomarker and therapeutic target role in HCC."	0.7052
32196590	European review for medical and pharmacological sciences	2020	"Circular RNA circDENND4C facilitates proliferation, migration and glycolysis of colorectal cancer cells through miR-760/GLUT1 axis."		circDENND4C	hsa_circ_DENND4C	DENND4C	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circDENND4C is up-regulated in colorectal cancer tissues and cells. It promotes colorectal cancer cell proliferation, migration, glycolysis, and xenograft tumor growth by sponging miR-760 to regulate GLUT1 expression. Knockdown of circDENND4C suppresses these malignant phenotypes, suggesting potential diagnostic or therapeutic relevance."	0.6521
32196598	European review for medical and pharmacological sciences	2020	Circ_0001971 regulates oral squamous cell carcinoma progression and chemosensitivity by targeting miR-194/miR-204 in vitro and in vivo.	hsa_circ_0001971	circ_0001971	hsa_circ_FAM126A	FAM126A	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"Circ_0001971 is up-regulated in OSCC tissues and cell lines and is associated with advanced TNM stage and poorer overall survival. Functionally, circ_0001971 promotes malignant phenotypes and DDP resistance while suppressing apoptosis, and its knockdown inhibits tumor progression and improves DDP sensitivity in vitro and in vivo. Mechanistically, circ_0001971 acts mainly in the cytoplasm and directly targets miR-194 and miR-204."	0.817
32196602	European review for medical and pharmacological sciences	2020	Circular RNA circ-ABCB10 promotes non-small cell lung cancer proliferation and inhibits cell apoptosis through repressing KISS1.	hsa_circ_0008717	circ-ABCB10	hsa_circ_ABCB10	ABCB10	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"In this study, circ-ABCB10/hsa_circ_0008717 was up-regulated in NSCLC tissues and cell lines. Knockdown experiments in H1299 cells indicated that circ-ABCB10 promotes proliferation and cell cycle progression while inhibiting apoptosis. Mechanistically, circ-ABCB10 was reported to suppress KISS1, suggesting an oncogenic role and potential therapeutic relevance in NSCLC."	0.5758
32196608	European review for medical and pharmacological sciences	2020	Circular RNA circ_0103552 promotes the invasion and migration of thyroid carcinoma cells by sponging miR-127.	hsa_circ_0103552	circ_0103552			thyroid cancer / TC	MONDO:0002108	thyroid cancer	up-regulated	RT-qPCR	"circ-0103552 is upregulated in thyroid carcinoma tissues and cell lines. Functionally, circ-0103552 promotes thyroid carcinoma cell migration and invasion, while its knockdown suppresses these malignant behaviors. Mechanistically, circ-0103552 directly interacts with and sponges miR-127, suggesting a circ-0103552/miR-127 regulatory mechanism and potential therapeutic relevance in TC."	0.6369
32196629	European review for medical and pharmacological sciences	2020	"Circular RNA TTBK2 regulates cell proliferation, invasion and ferroptosis via miR-761/ITGB8 axis in glioma."		Circular RNA Tau tubulin kinase 2 / circ-TTBK2	hsa_circ_TTBK2	TTBK2	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"Circ-TTBK2 is up-regulated in human glioma tissues and glioma cell lines. It promotes glioma proliferation, invasion and xenograft tumor growth while suppressing ferroptosis through a ceRNA mechanism in which circ-TTBK2 sponges miR-761 to upregulate ITGB8. The study proposes circ-TTBK2 as a potential therapeutic biomarker or target for human glioma."	0.7177
32218853	Oncology letters	2020	Comprehensive circular RNA profiling reveals the regulatory role of circ_100242/miR-145 pathway in bladder cancer.		hsa_circ_100241 / circ-100241			bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circ_100241 was identified by circRNA microarray and validated by RT-qPCR as significantly upregulated in bladder cancer tissues compared with adjacent normal tissues. The study did not report a specific mechanistic or functional validation for this circRNA.	0.5541
32218853	Oncology letters	2020	Comprehensive circular RNA profiling reveals the regulatory role of circ_100242/miR-145 pathway in bladder cancer.		hsa_circ_100242 / circ_100242			bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_100242 was significantly upregulated in bladder cancer tissues and validated by RT-qPCR. Bioinformatics analysis predicted that it contains miRNA response elements, especially for miR-145-5p/miR-145, suggesting that hsa_circ_100242 may contribute to bladder cancer initiation and progression through a circRNA-miRNA sponge mechanism."	0.585
32218853	Oncology letters	2020	Comprehensive circular RNA profiling reveals the regulatory role of circ_100242/miR-145 pathway in bladder cancer.		hsa_circ_101303 / circ-101303			bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	hsa_circ_101303 was identified by circRNA microarray and validated by RT-qPCR as significantly upregulated in bladder cancer tissues compared with adjacent normal tissues. The study did not report a specific mechanistic or functional validation for this circRNA.	0.5541
32218853	Oncology letters	2020	Comprehensive circular RNA profiling reveals the regulatory role of circ_100242/miR-145 pathway in bladder cancer.		hsa_circ_104510 / circ-104510			bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; Microarray	hsa_circ_104510 was identified by circRNA microarray and validated by RT-qPCR as significantly downregulated in bladder cancer tissues compared with adjacent normal tissues. The study did not report a specific mechanistic or functional validation for this circRNA.	0.5541
32226487	Experimental and therapeutic medicine	2020	Cisplatin resistance-associated circRNA_101237 serves as a prognostic biomarker in hepatocellular carcinoma.		circRNA_101237 / Circ_101237	hsa_circ_CDK8		hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"CircRNA_101237 is a human CDK8-derived circRNA upregulated in HCC tumor tissues and serum. Its high serum expression is associated with advanced clinicopathological features, poorer overall survival, and cisplatin resistance, supporting its role as a diagnostic/prognostic biomarker and potential therapeutic target, although its molecular mechanism was not determined."	0.6089
32271420	European review for medical and pharmacological sciences	2020	Association between hsa_circ_0006156 expression and incidence of gastric cancer.	hsa_circ_0006156				gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0006156 is significantly down-regulated in gastric cancer tissues compared with para-carcinoma tissues, and this finding was validated by RT-qPCR. Its reduced expression is associated with lymph node metastasis, nerve invasion, tumor recurrence, death, and poorer survival outcomes, suggesting prognostic biomarker potential."	0.5202
32271420	European review for medical and pharmacological sciences	2020	Association between hsa_circ_0006156 expression and incidence of gastric cancer.	hsa_circ_1878921				gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	Microarray	"Hsa_circ_1878921 was identified by microarray as one of six circRNAs significantly down-regulated in gastric cancer tissues compared with para-carcinoma tissues. No RT-qPCR validation, clinical correlation, functional assays, or mechanistic studies were reported for this circRNA."	0.2995
32271420	European review for medical and pharmacological sciences	2020	Association between hsa_circ_0006156 expression and incidence of gastric cancer.	hsa_circ_0001666				gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	Microarray	"Hsa_circ_0001666 was detected by microarray as significantly down-regulated in gastric cancer tissues. The article discusses it as a potential marker for clinical treatment of gastric cancer, but no circRNA-specific RT-qPCR validation or mechanistic experiments were reported in this study."	0.2995
32271420	European review for medical and pharmacological sciences	2020	Association between hsa_circ_0006156 expression and incidence of gastric cancer.	hsa_circ_0018909				gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	Microarray	"Hsa_circ_0018909 was identified by microarray as one of six circRNAs significantly down-regulated in gastric cancer tissues compared with para-carcinoma tissues. No RT-qPCR validation, clinical correlation, functional assays, or mechanistic studies were reported for this circRNA."	0.2995
32271420	European review for medical and pharmacological sciences	2020	Association between hsa_circ_0006156 expression and incidence of gastric cancer.	hsa_circ_0092145				gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	Microarray	"Hsa_circ_0092145 was identified by microarray as one of six circRNAs significantly down-regulated in gastric cancer tissues compared with para-carcinoma tissues. No RT-qPCR validation, clinical correlation, functional assays, or mechanistic studies were reported for this circRNA."	0.2995
32271420	European review for medical and pharmacological sciences	2020	Association between hsa_circ_0006156 expression and incidence of gastric cancer.	hsa_circ_0043277				gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	Microarray	"Hsa_circ_0043277 was identified by microarray as one of six circRNAs significantly down-regulated in gastric cancer tissues compared with para-carcinoma tissues. No RT-qPCR validation, clinical correlation, functional assays, or mechanistic studies were reported for this circRNA."	0.2995
32271424	European review for medical and pharmacological sciences	2020	Hsa_circ_001193 regulates proliferation and apoptosis of nasopharyngeal carcinoma cells through targeting mir-496.		hsa_circ_001193 / circ_001193			nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"hsa_circ_001193 is up-regulated in nasopharyngeal carcinoma cell lines compared with normal nasopharyngeal epithelial cells. Functionally, hsa_circ_001193 promotes NPC cell proliferation and colony formation and inhibits apoptosis; its knockdown suppresses proliferation and induces apoptosis. Mechanistically, the study supports a hsa_circ_001193/miR-496 regulatory axis, with hsa_circ_001193 acting as a miR-496 sponge."	0.5554
32271446	European review for medical and pharmacological sciences	2020	"Circ_CHFR expedites cell growth, migration and inflammation in ox-LDL-treated human vascular smooth muscle cells via the miR-214-3p/Wnt3/beta-catenin pathway."	hsa_circ_0029589	circ_CHFR	hsa_circ_CHFR	CHFR	Atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"Circ_CHFR is up-regulated in AS serum samples and ox-LDL-stimulated human VSMCs. It promotes VSMC growth, migration, and inflammation by sponging miR-214-3p, increasing Wnt3 expression, and enhancing Wnt3/beta-catenin signaling. The study suggests circ_CHFR may serve as a molecular indicator or therapeutic target for AS."	0.7177
32271695	Current cancer drug targets	2020	CircRNA SCARB1 Promotes Renal Cell Carcinoma Progression Via Mir- 510-5p/SDC3 Axis.		CircRNA SCARB1 / Circ-SCARB1	hsa_circ_SCARB1	SCARB1	Renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR	"Circ-SCARB1 is up-regulated in RCC tissues and cell lines and functions as an oncogenic circRNA. Mechanistically, it sponges miR-510-5p to relieve repression of SDC3, thereby promoting proliferation, migration and invasion while suppressing apoptosis in RCC cells."	0.7164
32319577	International journal of oncology	2020	Hsa_circ_0091074 regulates TAZ expression via microRNA_1297 in triple negative breast cancer cells.	hsa_circ_0091074		hsa_circ_XIST	XIST	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	down-regulated	RT-qPCR	"hsa_circ_0091074 was found to be expressed at low levels in breast cancer cell lines compared with MCF-10A cells, but functionally it appears to support TNBC cell proliferation and viability. Mechanistically, it binds miR-1297 as a sponge, thereby participating in the hsa_circ_0091074/miR-1297/TAZ/TEAD4 Hippo pathway-related axis. The study suggests this axis may be a potential therapeutic target for TNBC, although direct clinical validation of hsa_circ_0091074 was not performed."	0.5607
32329819	European review for medical and pharmacological sciences	2020	CircPSM3 inhibits the proliferation and differentiation of OA chondrocytes by targeting miRNA-296-5p.		CircPSM3			Osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"CircPSM3 is up-regulated in OA cartilage tissues and OA chondrocytes. It suppresses OA chondrocyte proliferation and differentiation by acting as a sponge for miR-296-5p, and the study suggests CircPSM3 as a potential therapeutic target for osteoarthritis."	0.6479
32329843	European review for medical and pharmacological sciences	2020	Circular RNA circCNOT6L regulates cell development through modulating miR-384/FN1 axis in esophageal squamous cell carcinoma.	hsa_circ_0006168	circCNOT6L / circ_0006168	hsa_circ_CNOT6L	CNOT6L	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"circCNOT6L is up-regulated in ESCC tissues and cells and functions as an oncogenic circRNA. It promotes ESCC cell proliferation, iron metabolism disorder and tumor growth while suppressing apoptosis, at least partly by sponging miR-384 to increase FN1 expression."	0.7785
32343678	The Journal of clinical investigation	2020	Circular RNA-ZNF532 regulates diabetes-induced retinal pericyte degeneration and vascular dysfunction.	hsa_circ_0047814	circ_0047814 / cZNF532	hsa_circ_ZNF532	ZNF532	diabetic retinopathy / DR	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR; Microarray	"cZNF532 is a high glucose- and diabetic stress-induced circRNA derived from ZNF532 that is upregulated in pericytes, diabetic mouse retinal vessels, and vitreous from patients with diabetic retinopathy. It protects retinal pericyte function and vascular integrity through a cZNF532/miR-29a-3p/NG2-LOXL2-CDK2 ceRNA mechanism, and its vitreous expression correlates with DR severity."	0.8237
32343678	The Journal of clinical investigation	2020	Circular RNA-ZNF532 regulates diabetes-induced retinal pericyte degeneration and vascular dysfunction.	mmu_circ_0000883	circ_0047814 / cZNF532	mmu_circ_ZNF532	ZNF532	diabetic retinopathy / DR	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR; Microarray	"cZNF532 is a high glucose- and diabetic stress-induced circRNA derived from ZNF532 that is upregulated in pericytes, diabetic mouse retinal vessels, and vitreous from patients with diabetic retinopathy. It protects retinal pericyte function and vascular integrity through a cZNF532/miR-29a-3p/NG2-LOXL2-CDK2 ceRNA mechanism, and its vitreous expression correlates with DR severity."	0.8237
32355548	American journal of translational research	2020	Comprehensive circular RNA profiling reveals the regulatory role of circRNA_0007694 in papillary thyroid carcinoma.		circRNA-000911			breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	"circRNA-000911 is downregulated in breast cancer tissues and cells. It acts as a tumor suppressor by sponging miR-449a, increasing Notch1 expression, suppressing NF-kappaB signaling, and inhibiting proliferation, migration and invasion while promoting apoptosis."	0.7981
32355548	American journal of translational research	2020	Comprehensive circular RNA profiling reveals the regulatory role of circRNA_0007694 in papillary thyroid carcinoma.		circRNA-001175			breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circRNA-001175 was identified by microarray and validated by RT-qPCR as an upregulated circRNA in breast cancer tissues. It also remained statistically significant in breast cancer cell lines, but the authors reported no significant effect of its silencing on cell viability and migration in preliminary experiments."	0.4773
32355548	American journal of translational research	2020	Comprehensive circular RNA profiling reveals the regulatory role of circRNA_0007694 in papillary thyroid carcinoma.		circRNA-100438			breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	circRNA-100438 was identified by circRNA microarray and confirmed by RT-qPCR as upregulated in breast cancer tissues compared with paired non-cancerous tissues. The study did not further characterize its molecular mechanism or biological function.	0.4773
32355548	American journal of translational research	2020	Comprehensive circular RNA profiling reveals the regulatory role of circRNA_0007694 in papillary thyroid carcinoma.		circRNA-001283			breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	circRNA-001283 was identified by circRNA microarray and confirmed by RT-qPCR as downregulated in breast cancer tissues compared with paired non-cancerous tissues. The study did not further characterize its molecular mechanism or biological function.	0.4773
32368390	American journal of cancer research	2020	Circular RNA circEIF3I promotes papillary thyroid carcinoma progression through competitively binding to miR-149 and upregulating KIF2A expression.		circEIF3I	hsa_circ_EIF3I	EIF3I	papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circEIF3I is up-regulated in papillary thyroid carcinoma tissues and cell lines and is associated with aggressive clinicopathological features. It promotes PTC proliferation, migration, invasion and in vivo tumor growth by sponging miR-149 and increasing KIF2A expression, forming a circEIF3I/miR-149/KIF2A regulatory axis."	0.6536
32368989	Current molecular pharmacology	2021	CircRNA 001418 Promoted Cell Growth and Metastasis of Bladder Carcinoma via EphA2 by miR-1297.		circ 001418			bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"circ 001418 is up-regulated in serum samples from patients with bladder carcinoma, and high expression is associated with poorer OS and DFS. Functionally, the study reports that circ 001418 promotes T24 bladder carcinoma cell growth and transfer/metastatic behavior and suppresses apoptosis. Mechanistically, circ 001418 acts through miR-1297 and regulates the EphA2/FADD/cytochrome c signaling-related protein network."	0.7369
32373952	European review for medical and pharmacological sciences	2020	Effects of hsa_circ_0000711 expression level on proliferation and apoptosis of hepatoma cells.	hsa_circ_0000711				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"This study identified hsa_circ_0000711 as differentially and lowly expressed in HCC tumor tissues based on microarray screening and RT-qPCR validation. Functionally, hsa_circ_0000711 promoted hepatoma cell proliferation and inhibited apoptosis. Mechanistically, it was reported to bind has-miR-103a-3p as a molecular sponge within a circRNA-miRNA-mRNA regulatory network, with predicted involvement in cell cycle and tumor-related signaling pathways."	0.6777
32373955	European review for medical and pharmacological sciences	2020	"Circ_0056618 promoted cell proliferation, migration and angiogenesis through sponging with miR-206 and upregulating CXCR4 and VEGF-A in colorectal cancer."	hsa_circ_0056618	circ_0056618			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0056618 is up-regulated in human colorectal cancer tissues and CRC cell lines, and high expression is associated with metastasis-related clinicopathological features and poor overall survival. Functionally, circ_0056618 promotes CRC cell proliferation, migration and angiogenesis. Mechanistically, it sponges miR-206 and upregulates CXCR4 and VEGF-A, suggesting a circ_0056618/miR-206/CXCR4-VEGF-A regulatory axis and potential prognostic or therapeutic value in CRC."	0.7396
32373963	European review for medical and pharmacological sciences	2020	CircRNA_001010 adsorbs miR-5112 in a sponge form to promote proliferation and metastasis of non-small cell lung cancer (NSCLC).		circRNA_001010 / circ-001010			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circRNA_001010 is up-regulated in human NSCLC tissues and A549 cells. It promotes proliferation, migration and invasion and inhibits apoptosis-related gene expression changes in NSCLC cells. Mechanistically, it functions as a ceRNA sponge for miR-5112 to increase CDK4 expression."	0.6479
32373969	European review for medical and pharmacological sciences	2020	Circ_0067934 correlates with poor prognosis and promotes laryngeal squamous cell cancer progression by sponging miR-1324.	hsa_circ_0067934	circ_0067934			laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR	"Circ_0067934 is up-regulated in LSCC tissues and cells and high expression predicts worse survival. Functionally, circ_0067934 promotes LSCC cell proliferation and migration, and mechanistically it acts as a sponge for miR-1324. The study suggests circ_0067934 may serve as a prognostic biomarker and therapeutic target for LSCC."	0.7113
32373972	European review for medical and pharmacological sciences	2020	Hsa_circ_0124055 and hsa_circ_0101622 regulate proliferation and apoptosis in thyroid cancer and serve as prognostic and diagnostic indicators.	hsa_circ_0124055		hsa_circ_DAG1		thyroid cancer / TC	MONDO:0002108	thyroid cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0124055 is up-regulated in thyroid cancer tissues, plasma, and thyroid cancer cell lines. Its high expression is associated with poorer clinicopathological features and shorter overall survival, and plasma levels show diagnostic value. Knockdown of hsa_circ_0124055 suppresses thyroid cancer cell proliferation, promotes apoptosis, and inhibits xenograft tumor growth."	0.7585
32373972	European review for medical and pharmacological sciences	2020	Hsa_circ_0124055 and hsa_circ_0101622 regulate proliferation and apoptosis in thyroid cancer and serve as prognostic and diagnostic indicators.	hsa_circ_0101622		hsa_circ_HEATR5A		thyroid cancer / TC	MONDO:0002108	thyroid cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0101622 is up-regulated in thyroid cancer tissues, plasma, and thyroid cancer cell lines. Its high expression is associated with poorer clinicopathological features and shorter overall survival, and plasma levels show diagnostic value. Knockdown of hsa_circ_0101622 suppresses thyroid cancer cell proliferation, promotes apoptosis, and inhibits xenograft tumor growth."	0.7585
32410429	Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery	2020	[Circular RNA expression pattern and competing endogenous RNA network involved in rotator cuff tendinopathy].		circRNA.3431	hsa_circ_COL1A1	COL1A1	rotator cuff tendinopathy	MONDO:0007028	rotator cuff syndrome	up-regulated	RNA-seq	"circRNA.3431 was identified as one of the most up-regulated circRNAs in rotator cuff tendinopathy tissue by circRNA sequencing. Its host gene is COL1A1, and the study suggests that differentially expressed circRNAs may provide potential diagnostic or therapeutic targets."	0.3991
32410429	Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery	2020	[Circular RNA expression pattern and competing endogenous RNA network involved in rotator cuff tendinopathy].	hsa_circ_0002980	circRNA.9521	hsa_circ_AGK	AGK	rotator cuff tendinopathy	MONDO:0007028	rotator cuff syndrome	up-regulated	RNA-seq	"circRNA.9521, also named hsa_circ_0002980, was identified as up-regulated in rotator cuff tendinopathy tissue. The study links differentially expressed circRNAs to potential disease mechanisms through pathway enrichment and ceRNA network analysis."	0.3991
32410429	Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery	2020	[Circular RNA expression pattern and competing endogenous RNA network involved in rotator cuff tendinopathy].	hsa_circ_0030117	circRNA.1787	hsa_circ_VWA8	VWA8	rotator cuff tendinopathy	MONDO:0007028	rotator cuff syndrome	up-regulated	RNA-seq	"circRNA.1787, also named hsa_circ_0030117, was identified as up-regulated in rotator cuff tendinopathy tissue. Its host gene is VWA8, and its disease association is supported by sequencing and bioinformatics analyses only."	0.3991
32410429	Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery	2020	[Circular RNA expression pattern and competing endogenous RNA network involved in rotator cuff tendinopathy].		circRNA.2737	hsa_circ_AKAP13	AKAP13	rotator cuff tendinopathy	MONDO:0007028	rotator cuff syndrome	up-regulated	RNA-seq	"circRNA.2737 was listed among the top up-regulated circRNAs in rotator cuff tendinopathy tissue, with AKAP13 reported as its parental gene. No circRNA-specific functional experiments were performed."	0.3991
32410429	Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery	2020	[Circular RNA expression pattern and competing endogenous RNA network involved in rotator cuff tendinopathy].		circRNA.6651	hsa_circ_VRK2	VRK2	rotator cuff tendinopathy	MONDO:0007028	rotator cuff syndrome	up-regulated	RNA-seq	"circRNA.6651 was listed among the top up-regulated circRNAs in rotator cuff tendinopathy tissue, with VRK2 reported as its parental gene. Evidence is limited to sequencing and bioinformatics analysis."	0.3991
32410429	Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery	2020	[Circular RNA expression pattern and competing endogenous RNA network involved in rotator cuff tendinopathy].	hsa_circ_0008788	circRNA.4724	hsa_circ_KCNK2	KCNK2	rotator cuff tendinopathy	MONDO:0007028	rotator cuff syndrome	down-regulated	RNA-seq	"circRNA.4724, also named hsa_circ_0008788, was the most strongly down-regulated circRNA among the down-regulated circRNAs reported in rotator cuff tendinopathy. Its parental gene is KCNK2."	0.3991
32410429	Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery	2020	[Circular RNA expression pattern and competing endogenous RNA network involved in rotator cuff tendinopathy].	hsa_circ_0005736	circRNA.5464	hsa_circ_RNF24	RNF24	rotator cuff tendinopathy	MONDO:0007028	rotator cuff syndrome	down-regulated	RNA-seq	"circRNA.5464, also named hsa_circ_0005736, was identified as down-regulated in rotator cuff tendinopathy tissue. RNF24 was reported as its parental gene."	0.3991
32410429	Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery	2020	[Circular RNA expression pattern and competing endogenous RNA network involved in rotator cuff tendinopathy].		circRNA.10482	hsa_circ_C9orf84	C9orf84	rotator cuff tendinopathy	MONDO:0007028	rotator cuff syndrome	down-regulated	RNA-seq	"circRNA.10482 was identified as down-regulated in rotator cuff tendinopathy tissue, with C9orf84 reported as its parental gene. Its functional relevance was proposed from differential expression and bioinformatics analysis."	0.3991
32410429	Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery	2020	[Circular RNA expression pattern and competing endogenous RNA network involved in rotator cuff tendinopathy].	hsa_circ_0087630	circRNA.10893	hsa_circ_HABP4	HABP4	rotator cuff tendinopathy	MONDO:0007028	rotator cuff syndrome	down-regulated	RNA-seq	"circRNA.10893, also named hsa_circ_0087630, was identified as down-regulated in rotator cuff tendinopathy tissue. Its parental gene is HABP4."	0.3991
32410429	Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery	2020	[Circular RNA expression pattern and competing endogenous RNA network involved in rotator cuff tendinopathy].	hsa_circ_0001498	circRNA.8658	hsa_circ_WDR41	WDR41	rotator cuff tendinopathy	MONDO:0007028	rotator cuff syndrome	down-regulated	RNA-seq	"circRNA.8658, also named hsa_circ_0001498, was identified as down-regulated in rotator cuff tendinopathy tissue. Its parental gene is WDR41."	0.3991
32410429	Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery	2020	[Circular RNA expression pattern and competing endogenous RNA network involved in rotator cuff tendinopathy].		circRNA.8442			rotator cuff tendinopathy	MONDO:0007028	rotator cuff syndrome	dysregulated	RNA-seq	"circRNA.8442 was identified as the circRNA with the most connections in the predicted ceRNA network for rotator cuff tendinopathy. The article suggests that such core noncoding RNAs may be important in disease occurrence, but no wet-lab validation was performed."	0.3991
32410429	Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery	2020	[Circular RNA expression pattern and competing endogenous RNA network involved in rotator cuff tendinopathy].		circRNA.8951			rotator cuff tendinopathy	MONDO:0007028	rotator cuff syndrome	dysregulated	RNA-seq	"circRNA.8951 was proposed as part of the highest-free-energy predicted ceRNA regulatory axis, circRNA.8951-has-miR-6089-DNMT3B, in rotator cuff tendinopathy. This axis was generated bioinformatically and remains to be validated experimentally."	0.3991
32432729	European review for medical and pharmacological sciences	2020	Caprin1 targeted by circular circ_0000885 in the tumor progression of osteosarcoma.	hsa_circ_0000885	circ_0000885			osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ_0000885 is up-regulated in osteosarcoma tissues and cell lines. Knockdown experiments in MG-63 cells indicate that circ_0000885 promotes osteosarcoma cell proliferation and cell-cycle progression, at least partly by upregulating Caprin1 expression. The study suggests circ_0000885 as a potential therapeutic target for osteosarcoma."	0.5414
32453598	Neoplasma	2020	Circular RNA circ_0000615 knockdown suppresses the development of nasopharyngeal cancer through regulating the miR-338-3p/FGF2 axis.	hsa_circ_0000615	circ_0000615 / circRNA ZNF609	hsa_circ_ZNF609	ZNF609	nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"Circ_0000615 is upregulated in NPC tissues and cells and appears to act as an oncogenic circRNA. Its knockdown suppresses proliferation, migration, invasion, EMT, and xenograft tumor growth by releasing miR-338-3p-mediated inhibition of FGF2, forming a circ_0000615/miR-338-3p/FGF2 regulatory axis."	0.7404
32495861	European review for medical and pharmacological sciences	2020	CircRNA_MYLK promotes malignant progression of ovarian cancer through regulating microRNA-652.		circRNA_MYLK	hsa_circ_MYLK	MYLK	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circRNA_MYLK is up-regulated in ovarian cancer tissues and cell lines and promotes ovarian cancer cell proliferation. Mechanistically, it binds to and regulates microRNA-652, and its high expression is associated with higher pathological stage and poor prognosis in ovarian cancer patients."	0.6987
32495863	European review for medical and pharmacological sciences	2020	Circular RNA_LARP4 inhibits cell migration and invasion of prostate cancer by targeting FOXO3A.		circular RNA_LARP4	hsa_circ_LARP4	LARP4	prostate cancer / PCa	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR	"Circular RNA_LARP4 is downregulated in prostate cancer tissues and cell lines, and low expression is associated with poorer overall survival. Functional experiments indicate that circular RNA_LARP4 overexpression suppresses DU145 cell migration and invasion, likely through upregulation of FOXO3A."	0.6527
32495864	European review for medical and pharmacological sciences	2020	Circ_0061140 promotes metastasis of bladder cancer through adsorbing microRNA-1236.	hsa_circ_0061140	circ_0061140			bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ_0061140 is up-regulated in bladder cancer tissues and cell lines. Its high expression is associated with lymph node or distant metastasis and poor prognosis, and functional assays indicate that it promotes proliferation, invasion, migration, metastasis, and EMT-related changes. Mechanistically, circ_0061140 specifically binds and regulates microRNA-1236, and miR-1236 knockdown rescues the suppressive effects of circ_0061140 knockdown on bladder cancer cell functions."	0.7078
32495888	European review for medical and pharmacological sciences	2020	Sevoflurane impedes the progression of glioma through modulating the circular RNA has_circ_0012129/miR-761/TGIF2 axis.	hsa_circ_0012129	circ_0012129			glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"hsa_circ_0012129/circ_0012129 is up-regulated in glioma tissues and glioma cell lines. Sevoflurane down-regulates circ_0012129, and circ_0012129 overexpression reverses sevoflurane-induced inhibition of glioma progression by promoting cell viability, colony formation, cell cycle, migration, invasion, glycolytic activity and tumor growth while suppressing apoptosis. Mechanistically, circ_0012129 acts through the miR-761/TGIF2 axis."	0.6544
32495924	European review for medical and pharmacological sciences	2020	Roles of circ-CSPP1 on the proliferation and metastasis of glioma cancer.		circ-CSPP1	hsa_circ_CSPP1	CSPP1	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ-CSPP1 is up-regulated in glioma cancer tissues and cell lines. Functional knockdown experiments in U87 cells indicate that circ-CSPP1 promotes glioma cell proliferation, migration, invasion, and EMT-associated behavior, suggesting potential therapeutic relevance."	0.5434
32509073	International journal of clinical and experimental pathology	2020	Expression of circRNA circ_0026344 in gastric cancer and its clinical significance.	hsa_circ_0026344	Circ_0026344			gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"This study found that circ_0026344 is downregulated in gastric cancer tissues and gastric cancer cell lines. Low circ_0026344 expression is associated with malignant clinicopathologic features and worse overall survival, supporting its potential value as a prognostic biomarker in gastric cancer."	0.6089
32509077	International journal of clinical and experimental pathology	2020	Differential expression profiles of circRNAs in human prostate cancer based on chip and bioinformatic analysis.	hsa_circ_0033074	Circ_0033074	hsa_circ_SERPINA3	SERPINA3	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	Microarray	"Circ_0033074 was identified by microarray as the most strongly upregulated circRNA in PCA tissues compared with matched non-cancerous tissues. The study linked it bioinformatically to its host gene SERPINA3 and suggested that differentially expressed circRNAs may serve as future PCA biomarkers, but no RT-qPCR or functional validation was performed."	0.348
32509077	International journal of clinical and experimental pathology	2020	Differential expression profiles of circRNAs in human prostate cancer based on chip and bioinformatic analysis.	hsa_circ_0016064	Circ_0016064	hsa_circ_MYBPH	MYBPH	prostate cancer / PCa	MONDO:0008315	prostate cancer	down-regulated	Microarray	"Circ_0016064 was identified by microarray as the most strongly downregulated circRNA in PCA tissues compared with matched non-cancerous tissues. The study linked it bioinformatically to its host gene MYBPH and suggested that differentially expressed circRNAs may serve as future PCA biomarkers, but no RT-qPCR or functional validation was performed."	0.348
32509169	American journal of translational research	2020	Circular RNA profile of acute myeloid leukaemia indicates circular RNA annexin A2 as a potential biomarker and therapeutic target for acute myeloid leukaemia.		circ-RPS6KB1 / circRNA-RPS6KB1	hsa_circ_RPS6KB1	RPS6KB1	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; Microarray	"circ-RPS6KB1 was validated by RT-qPCR as up-regulated in AML BMMCs. It showed diagnostic potential for distinguishing AML patients from healthy controls, but no significant survival association was reported."	0.636
32509169	American journal of translational research	2020	Circular RNA profile of acute myeloid leukaemia indicates circular RNA annexin A2 as a potential biomarker and therapeutic target for acute myeloid leukaemia.		circ-CSMD2 / circRNA-CSMD2	hsa_circ_CSMD2	CSMD2	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; Microarray	"circ-CSMD2 was validated by RT-qPCR as up-regulated in AML BMMCs. It showed diagnostic potential for distinguishing AML patients from healthy controls, but no significant survival association was reported."	0.636
32509169	American journal of translational research	2020	Circular RNA profile of acute myeloid leukaemia indicates circular RNA annexin A2 as a potential biomarker and therapeutic target for acute myeloid leukaemia.		circ-PTK2	hsa_circ_PTK2	PTK2	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; Microarray	"circ-PTK2 was validated by RT-qPCR as up-regulated in AML BMMCs. Unlike several other validated candidates, it did not significantly distinguish AML patients from healthy controls in ROC analysis and had no reported survival association."	0.636
32509169	American journal of translational research	2020	Circular RNA profile of acute myeloid leukaemia indicates circular RNA annexin A2 as a potential biomarker and therapeutic target for acute myeloid leukaemia.		circular RNA annexin A2 / circ-ANXA2	hsa_circ_ANXA2	ANXA2	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; Microarray	"circ-ANXA2 is up-regulated in AML patient BMMCs and AML cell lines. High circ-ANXA2 expression is associated with adverse clinical features and poor survival, while knockdown suppresses proliferation, promotes apoptosis and increases chemosensitivity, potentially through negative regulation of miR-23a-5p and miR-503-3p."	0.7513
32509169	American journal of translational research	2020	Circular RNA profile of acute myeloid leukaemia indicates circular RNA annexin A2 as a potential biomarker and therapeutic target for acute myeloid leukaemia.		circ-PWP2	hsa_circ_PWP2	PWP2	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	down-regulated	RT-qPCR; Microarray	"circ-PWP2 was validated by RT-qPCR as down-regulated in AML BMMCs. It showed diagnostic potential for distinguishing AML patients from healthy controls, but no significant survival association was reported."	0.636
32509169	American journal of translational research	2020	Circular RNA profile of acute myeloid leukaemia indicates circular RNA annexin A2 as a potential biomarker and therapeutic target for acute myeloid leukaemia.		circ-RBM5 / circRNA-RBM5	hsa_circ_RBM5	RBM5	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	down-regulated	RT-qPCR; Microarray	"circ-RBM5 was validated by RT-qPCR as down-regulated in AML BMMCs. It showed diagnostic potential for distinguishing AML patients from healthy controls, but no significant survival association was reported."	0.636
32509169	American journal of translational research	2020	Circular RNA profile of acute myeloid leukaemia indicates circular RNA annexin A2 as a potential biomarker and therapeutic target for acute myeloid leukaemia.		circ-ZZEF1	hsa_circ_ZZEF1	ZZEF1	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	down-regulated	RT-qPCR; Microarray	"circ-ZZEF1 was validated by RT-qPCR as down-regulated in AML BMMCs. It showed diagnostic potential for distinguishing AML patients from healthy controls, but no significant survival association was reported."	0.636
32509169	American journal of translational research	2020	Circular RNA profile of acute myeloid leukaemia indicates circular RNA annexin A2 as a potential biomarker and therapeutic target for acute myeloid leukaemia.		circ-GSK3B / circRNA-GSK38	hsa_circ_GSK3B	GSK3B	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	down-regulated	RT-qPCR; Microarray	"circ-GSK3B was validated by RT-qPCR as down-regulated in AML BMMCs. It showed diagnostic potential for distinguishing AML patients from healthy controls, but no significant survival association was reported."	0.636
32509169	American journal of translational research	2020	Circular RNA profile of acute myeloid leukaemia indicates circular RNA annexin A2 as a potential biomarker and therapeutic target for acute myeloid leukaemia.		circ-FOXP1 / circRNA-FOXP1	hsa_circ_FOXP1	FOXP1	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	down-regulated	RT-qPCR; Microarray	"circ-FOXP1 was validated by RT-qPCR as down-regulated in AML BMMCs. It showed diagnostic potential for distinguishing AML patients from healthy controls, and the authors speculated that it might affect transcription of its parental gene FOXP1, but no direct mechanistic validation was provided."	0.636
32552951	Zhongguo shi yan xue ye xue za zhi	2020	[Relationship of Expression of Circ_cgga162 with the Prognosis of Patients with Mantle Cell Lymphoma].		Circ_cgga162			mantle cell lymphoma / MCL	MONDO:0018876	mantle cell lymphoma	up-regulated	RT-qPCR	"Circ-cggal62 was measured in serum from MCL patients and reactive hyperplasia controls by qRT-PCR. It was up-regulated in MCL, correlated with adverse clinicopathological features, and high expression predicted shorter PFS and OS, supporting its role as a potential prognostic biomarker."	0.4758
32567935	Neoplasma	2020	CircABCB10 silencing inhibits the cell ferroptosis and apoptosis by regulating the miR-326/CCL5 axis in rectal cancer.		circABCB10	hsa_circ_ABCB10		renal carcinoma	MONDO:0005206	renal carcinoma	up-regulated	RT-qPCR	"circABCB10 is up-regulated in rectal cancer tissues and cell lines and functions as an oncogenic circRNA. Silencing circABCB10 promotes ferroptosis and apoptosis and suppresses xenograft tumor growth. Mechanistically, circABCB10 sponges miR-326 to positively regulate CCL5 expression, forming a circABCB10/miR-326/CCL5 regulatory axis."	0.7591
32572876	European review for medical and pharmacological sciences	2020	Hsa_circRNA_101036 acts as tumor-suppressor in oral squamous cell carcinoma cells via inducing endoplasmic reticulum stress.		hsa_circRNA_101036 / circRNA-101036	hsa_circ_TMTC1	TMTC1	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR	"Hsa_circRNA_101036 is down-regulated in OSCC cell lines and functions as a tumor suppressor in this study. Its overexpression induces ER stress with increased ROS, CHOP and p38, promotes apoptosis, and suppresses proliferation, migration and invasion in OECM1 and HSC3 cells, suggesting potential therapeutic relevance for OSCC."	0.5706
32572877	European review for medical and pharmacological sciences	2020	CircRNA_002178 promotes the proliferation and migration of oral squamous cell carcinoma cells by activating the Akt/mTOR pathway.		CircRNA_002178			oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"CircRNA_002178 is up-regulated in OSCC tissues and cell lines. Its high expression is associated with advanced pathological stage, distant metastasis and poor prognosis, while knockdown suppresses OSCC cell proliferation and migration. Mechanistically, the study supports that circRNA_002178 promotes OSCC malignant progression through activation of the Akt/mTOR signaling pathway."	0.6795
32572881	European review for medical and pharmacological sciences	2020	CircABCB10 promotes the proliferation and migration of lung cancer cells through down-regulating microRNA-217 expression.		circABCB10	hsa_circ_ABCB10	ABCB10	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circABCB10 is up-regulated in lung cancer tissues and cell lines, and high expression is associated with poor prognosis. Functionally, circABCB10 promotes lung cancer cell proliferation and migration. Mechanistically, circABCB10 binds to and down-regulates microRNA-217, forming a circABCB10/microRNA-217 regulatory axis that contributes to lung cancer progression."	0.7126
32572886	European review for medical and pharmacological sciences	2020	Circ-RPL15/miR-146b-3p/VEGFA feedback loop is responsible for triggering proliferation and migration in glioma.		circ-RPL15	hsa_circ_RPL15	RPL15	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ-RPL15 is up-regulated in glioma tissues and glioma cell lines, with higher expression in larger tumors. It is mainly cytoplasmic and promotes glioma cell proliferation and migration by competitively binding miR-146b-3p and upregulating VEGFA through the circ-RPL15/miR-146b-3p/VEGFA feedback loop."	0.6676
32572887	European review for medical and pharmacological sciences	2020	Circ_001680 stimulates glioma progression with the involvement of miR-186-5p.		circ_001680			glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"Circ_001680 is up-regulated in glioma tissues and glioma cell lines. It promotes glioma proliferation, migration, invasion and metastatic potential, at least partly by binding and negatively regulating miR-186-5p. Clinically, high circ_001680 expression is associated with lymphatic metastasis, distant metastasis and poorer survival in glioma patients."	0.7365
32572915	European review for medical and pharmacological sciences	2020	Circ_0000515 drives the progression of hepatocellular carcinoma by regulating MAPK10.	hsa_circ_0000515	circ_0000515			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0000515 is upregulated in HCC tissues and cell lines and high expression is associated with advanced stage, lymphatic metastasis, and poor survival. Functionally, circ_0000515 promotes HCC cell proliferation, migration and xenograft tumor growth. Mechanistically, it binds and negatively regulates MAPK10, contributing to malignant HCC progression."	0.7396
32572921	European review for medical and pharmacological sciences	2020	Circular RNA hsa_circ_103809 promotes cell migration and invasion of gastric cancer cells by binding to microRNA-101-3p.		hsa_circ_103809	hsa_circ_ZFR	ZFR	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"hsa_circ_103809 is up-regulated in gastric cancer tissues and cell lines and high expression is associated with poor prognosis. Functionally, it promotes gastric cancer cell migration and invasion. Mechanistically, it acts as a ceRNA/sponge for microRNA-101-3p, and hsa_circ_103809 overexpression reverses the inhibitory effect of microRNA-101-3p on gastric cancer cell migration and invasion."	0.6987
32572922	European review for medical and pharmacological sciences	2020	Circ_001680 aggravates the malignant process of gastric carcinoma by targeting MAP2.		circ_001680			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_001680 is up-regulated in gastric carcinoma tissues and cell lines, and high expression is associated with lymphatic metastasis, distant metastasis and poor survival. Functionally, circ_001680 promotes GC cell proliferation, migration and invasion, at least partly through a negative circ_001680-MAP2 regulatory axis."	0.7365
32572924	European review for medical and pharmacological sciences	2020	Circ-ABCB10 promotes proliferation and invasion of esophageal squamous cell carcinoma cells by modulating microRNA-670-3p.		Circ-ABCB10	hsa_circ_ABCB10	ABCB10	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"Circ-ABCB10 is up-regulated in ESCC tissues and cell lines and its high expression is associated with advanced stage and poor overall survival. Functionally, circ-ABCB10 promotes ESCC cell proliferation, migration and invasion. Mechanistically, it directly binds microRNA-670-3p and inhibits its expression, forming a circ-ABCB10/microRNA-670-3p regulatory axis."	0.6987
32633323	"Clinical science (London, England : 1979)"	2020	Circular RNA circFGD4 suppresses gastric cancer progression via modulating miR-532-3p/APC/beta-catenin signalling pathway.	hsa_circ_0000390	circFGD4	hsa_circ_FGD4	FGD4	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"circFGD4 is a human FGD4-derived circRNA that is down-regulated in gastric cancer tissues and cell lines. It functions as a tumor suppressor by sponging miR-532-3p, increasing APC expression, and inactivating beta-catenin/Wnt/beta-catenin signaling, thereby inhibiting GC proliferation, migration, EMT, tumorigenesis and metastasis. Clinically, low circFGD4 expression is associated with poor differentiation, lymphatic metastasis and poor prognosis, supporting its potential as a GC biomarker and therapeutic target."	0.8961
32633341	European review for medical and pharmacological sciences	2020	Circ100284 promotes invasion and migration of osteosarcoma cells by down-regulating PTEN and EMP1.		circ100284			osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"Circ100284 is up-regulated in human osteosarcoma tissues and cell lines, and high expression is associated with larger tumors, higher WHO grade, lung metastasis, and poorer survival. Functionally, circ100284 promotes OS cell viability, proliferation, migration, invasion, and cell-cycle progression while suppressing apoptosis. Mechanistically, it binds LSD1 and EZH2 and epigenetically represses PTEN and EMP1 expression."	0.7624
32633357	European review for medical and pharmacological sciences	2020	Circ_0032627 accelerates proliferation of gastric cancer cells through regulating miR-502-5p expression.	hsa_circ_0032627	circ_0032627			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_0032627 is up-regulated in human gastric cancer cell lines compared with a human gastric mucosal cell line. Functionally, circ_0032627 promotes gastric cancer cell proliferation and suppresses apoptosis. Mechanistically, it acts as a sponge of miR-502-5p, thereby contributing to gastric cancer development and progression."	0.5554
32633368	European review for medical and pharmacological sciences	2020	Circle RNA FOXP1 promotes cell proliferation in lung cancer by regulating miR-185-5p/Wnt1 signaling pathway.	hsa_circ_0008234	Circle RNA FOXP1 / circ-FOXP1	hsa_circ_FOXP1	FOXP1	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	circFOXP1 (hsa_circ_0008234) is up-regulated in LUAD tissues and cell lines. It promotes LUAD cell proliferation and suppresses apoptosis by acting as a miR-185-5p sponge and increasing WNT1 expression. The study suggests circFOXP1 may function as an oncogenic circRNA and potential therapeutic target in LUAD.	0.6815
32633371	European review for medical and pharmacological sciences	2020	CircDDX17 acts as a competing endogenous RNA for miR-605 in breast cancer progression.	hsa_circ_0002211	CircDDX17	hsa_circ_DDX17	DDX17	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	"circDDX17 is downregulated in breast cancer tissues and cell lines and acts as a tumour suppressor. It sponges miR-605 to regulate cell cycle-related proteins CDK1 and p21, thereby inhibiting proliferation and colony formation, inducing cell cycle arrest, and promoting apoptosis. Its reduced expression is associated with aggressive clinicopathological features, suggesting biomarker and therapeutic potential."	0.6829
32633377	European review for medical and pharmacological sciences	2020	Circ-ABCB10 acts as an oncogene in glioma cells via regulation of the miR-620/FABP5 axis.		circular RNA ABCB10 / circ-ABCB10	hsa_circ_ABCB10	ABCB10	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"Circ-ABCB10 is up-regulated in glioma tissues and glioma cell lines. It promotes glioma cell proliferation, migration, invasion and cell cycle progression while suppressing apoptosis, at least partly through the miR-620/FABP5 regulatory axis. The study suggests circ-ABCB10 as a potential therapeutic target for glioma."	0.6835
32655790	American journal of translational research	2020	CircAPLP2 regulates the proliferation and metastasis of colorectal cancer by targeting miR-101-3p to activate the Notch signalling pathway.		circAPLP2	hsa_circ_APLP2		colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circAPLP2 is upregulated in colorectal cancer tissues and cells. It promotes CRC proliferation, migration, invasion, tumour growth and liver metastasis by sponging miR-101-3p, increasing Notch1 expression and activating Notch signalling-associated proliferation and metastasis proteins."	0.7132
32655792	American journal of translational research	2020	CircMMP11 acts as a ce-circRNA in breast cancer progression by regulating miR-1204.	hsa_circ_0062558	circMMP11	hsa_circ_MMP11	MMP11	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circMMP11/hsa_circ_0062558 is upregulated in breast cancer tissues and cell lines and is associated with lymph node metastasis and TNM stage. It promotes breast cancer proliferation, migration and invasion by acting as a ce-circRNA sponge for miR-1204, thereby regulating MMP11 expression. The study suggests circMMP11 may be a potential therapeutic target in breast cancer."	0.7858
32658427	Clinical laboratory	2020	Enhanced CDR1as Promotes the Development of Bladder Urothelial Carcinoma.		CDR1as			bladder urothelial carcinoma	MONDO:0005611	bladder transitional cell carcinoma	up-regulated	RT-qPCR	"This clinical study found that CDR1as is up-regulated in bladder urothelial carcinoma tissues compared with adjacent normal tissues. Higher CDR1as expression was associated with more advanced clinicopathological features, including grade and lymph node positivity, and ROC analysis suggested diagnostic potential. No experimentally validated downstream molecular mechanism was reported."	0.4187
32683852	Minerva medica	2024	Circular RNA circFANCL motivates the glioma progression via the action on the miR-337-3p/HMGB1 signal axis.	hsa_circ_0001009	CircRNA Fanconi anemia group L protein / circFANCL	hsa_circ_FANCL	FANCL	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circFANCL is up-regulated in glioma tissues and cell lines and high circFANCL expression is associated with poor overall survival. Functionally, circFANCL promotes glioma cell proliferation, cell cycle progression and in vivo tumor growth while suppressing apoptosis. Mechanistically, it sponges miR-337-3p to up-regulate HMGB1, forming a circFANCL/miR-337-3p/HMGB1 regulatory axis."	0.8324
32700752	Oncology reports	2020	"Circulating RNAs, circ_4911 and circ_4302, are novel regulators of endothelial cell function under a hepatocellular carcinoma microenvironment."		circ_4911			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"circ_4911 was one of the most significantly downregulated circRNAs in HUVECs exposed to an HCC microenvironment. Its overexpression inhibited endothelial proliferation and migration, induced G0/G1 arrest, promoted adhesion-associated E-cadherin expression, and suppressed EGFR/p38 activation, suggesting a regulatory role in HCC-associated endothelial cell dysfunction and angiogenesis-related processes."	0.5067
32700752	Oncology reports	2020	"Circulating RNAs, circ_4911 and circ_4302, are novel regulators of endothelial cell function under a hepatocellular carcinoma microenvironment."		circ_4302			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"circ_4302 was one of the most significantly downregulated circRNAs in HUVECs exposed to an HCC microenvironment. Its overexpression reduced endothelial cell viability and migration, induced G0/G1 arrest, enhanced E-cadherin expression, and suppressed p-EGFR/p-p38 and cyclin D1, indicating a regulatory role in endothelial functions relevant to HCC progression."	0.5067
32706069	European review for medical and pharmacological sciences	2020	CircRNA_010763 promotes growth and invasion of lung cancer through serving as a molecular sponge of miR-715 to induce c-Myc expression.		circRNA_010763			lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circRNA_010763 is up-regulated in human NSCLC tissues and A549 cells. It promotes NSCLC cell proliferation, migration and invasion by sponging miR-715 and upregulating c-Myc expression, and it is proposed as a potential molecular marker for poor prognosis in NSCLC."	0.6369
32706196	Journal of integrative neuroscience	2020	The silent information regulator 1 pathway attenuates ROS-induced oxidative stress in Alzheimer's disease.	rno_circ_0001588	circRNA 0001588			Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR; Microarray	"CircRNA 0001588 is down-regulated in the Alzheimer's disease rat model. In AD-related in vivo and in vitro models, circRNA 0001588 exerts neuroprotective and antioxidant effects by negatively regulating miR-211-5p and activating the SIRT1/Nrf2/HO-1 pathway, thereby promoting cell growth and reducing caspase activity, LDH activity, ROS, and MDA."	0.5699
32720791	Panminerva medica	2024	Circular RNA circRHOBTB3 inhibits ovarian cancer progression through PI3K/AKT signaling pathway.		circular RNA RHOBTB3 / circRHOBTB3	hsa_circ_RHOBTB3	RHOBTB3	ovarian cancer / OC	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR	"circRHOBTB3 is down-regulated in ovarian cancer tissues and cells. It functions as a tumor suppressor by inhibiting proliferation, migration, invasion, metastasis, glycolysis and tumor growth, partly through inactivation of the PI3K/AKT signaling pathway."	0.5802
32727645	Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology	2020	[Circular RNA homeodomain-interacting protein kinase 3 (circHIPK3) promotes growth and metastasis of glioma cells by sponging miR-124-3p].		circular RNA homeodomain-interacting protein kinase 3 / circHIPK3	hsa_circ_HIPK3	HIPK3	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in glioma tissues and glioma cell lines. It promotes glioma cell proliferation, invasion, EMT, growth and metastasis by sponging miR-124-3p and reducing miR-124-3p-mediated inhibition of WEE1. The study suggests circHIPK3 may serve as a molecular target for glioma diagnosis and treatment."	0.6479
32727649	Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology	2020	[Highly expressed circular RNA hsa_circ_0017247 promotes osteosarcoma cell invasion and migration].	hsa_circ_0017247				osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"hsa_circ_0017247 is up-regulated in osteosarcoma tissues and Saos-2 osteosarcoma cells. Its high expression is associated with advanced clinical stage and metastasis, and siRNA-mediated knockdown suppresses Saos-2 cell invasion and migration. The study suggests that hsa_circ_0017247 promotes osteosarcoma progression by accelerating EMT through regulation of E-cadherin and N-cadherin expression."	0.5214
32767318	European review for medical and pharmacological sciences	2020	CircTMBIM6 promotes osteoarthritis-induced chondrocyte extracellular matrix degradation via miR-27a/MMP13 axis.		circTMBIM6	hsa_circ_TMBIM6	TMBIM6	Osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circTMBIM6 is up-regulated in cartilage from osteoarthritis patients and in IL-1beta/TNF-alpha-induced chondrocyte models. The study supports that circTMBIM6 promotes osteoarthritis-associated extracellular matrix degradation through a ceRNA-like circTMBIM6/miR-27a/MMP13 regulatory axis, making it a potential therapeutic target for osteoarthritis."	0.6427
32767319	European review for medical and pharmacological sciences	2020	Low expression of CircRNA HIPK3 promotes osteoarthritis chondrocyte apoptosis by serving as a sponge of miR-124 to regulate SOX8.		Circular RNA HIPK3 / CircHIPK3	hsa_circ_HIPK3	HIPK3	osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"CircHIPK3 is significantly up-regulated in human osteoarthritis cartilage tissue and OA chondrocytes. It functions through a CircHIPK3/miR-124/SOX8 regulatory axis, where CircHIPK3 sponges miR-124 to regulate SOX8 and thereby inhibits OA chondrocyte apoptosis; knockdown of CircHIPK3 increases miR-124 activity, suppresses SOX8, and promotes apoptosis."	0.6099
32767322	European review for medical and pharmacological sciences	2020	CircRNA UBAP2 facilitates the progression of colorectal cancer by regulating miR-199a/VEGFA pathway.		circRNA UBAP2 / circUBAP2	hsa_circ_UBAP2	UBAP2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circUBAP2 is upregulated in colorectal cancer tissues and cell lines. It promotes CRC cell proliferation, migration, and invasion by sponging miR-199a and thereby upregulating VEGFA, suggesting a potential therapeutic biomarker role in CRC."	0.6521
32774714	American journal of translational research	2020	circ_BICD2 acts as a ceRNA to promote tumor progression and Warburg effect in oral squamous cell carcinoma by sponging miR-107 to enhance HK2.	hsa_circ_0001874	circ_BICD2 / circ_0001874	hsa_circ_BICD2	BICD2	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circ_BICD2 is upregulated in OSCC tissues and cell lines and is associated with tumor size, TNM stage and lymph node metastasis. Functionally, circ_BICD2 promotes OSCC proliferation, migration, invasion, EMT-related phenotypes, tumor growth and aerobic glycolysis. Mechanistically, it acts as a ceRNA for miR-107 to enhance HK2 expression and the HK2-mediated Warburg effect."	0.7548
32774748	American journal of translational research	2020	Circular RNA circMAGI3 accelerates the glycolysis of non-small cell lung cancer through miR-515-5p/HDGF.	hsa_circ_0110498	circMAGI3	hsa_circ_MAGI3	MAGI3	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circMAGI3 is a human MAGI3-derived circRNA that is up-regulated in NSCLC tissues and cell lines and is associated with poor survival. It promotes NSCLC glycolysis, proliferation, and xenograft tumor growth by sponging miR-515-5p and relieving HDGF expression."	0.8318
32776759	Clinical laboratory	2020	Diagnostic Value of Serum hsa_circ_0141720 in Patients with Acute Ischemic Stroke.	hsa_circ_0141720				ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; Microarray	"hsa_circ_0141720 is up-regulated in serum from ACI patients and showed diagnostic potential with high sensitivity and specificity in ROC analysis. Its expression positively correlates with NIHSS score, infarct volume, IL-6 and hs-CRP, suggesting association with stroke severity and inflammation."	0.5047
32776759	Clinical laboratory	2020	Diagnostic Value of Serum hsa_circ_0141720 in Patients with Acute Ischemic Stroke.	hsa_circ_0141567				cerebral infarction	MONDO:0002679	cerebral infarction	up-regulated	Microarray	"hsa_circ_0141567 was identified by microarray as an up-regulated serum circRNA in ACI patients. Its disease association was not individually validated by reported RT-qPCR results, and functional information was limited to pathway enrichment of the differentially expressed circRNA set."	0.348
32776759	Clinical laboratory	2020	Diagnostic Value of Serum hsa_circ_0141720 in Patients with Acute Ischemic Stroke.	hsa_circ_0141726				cerebral infarction	MONDO:0002679	cerebral infarction	up-regulated	Microarray	"hsa_ circ_0141726 was identified by microarray as an up-regulated serum circRNA in ACI patients. Its disease association was not individually validated by reported RT-qPCR results, and functional information was limited to pathway enrichment of the differentially expressed circRNA set."	0.348
32776759	Clinical laboratory	2020	Diagnostic Value of Serum hsa_circ_0141720 in Patients with Acute Ischemic Stroke.	hsa_circ_0141808				cerebral infarction	MONDO:0002679	cerebral infarction	up-regulated	Microarray	"hsa_circ_0141808 was identified by microarray as an up-regulated serum circRNA in ACI patients. Its disease association was not individually validated by reported RT-qPCR results, and functional information was limited to pathway enrichment of the differentially expressed circRNA set."	0.348
32776759	Clinical laboratory	2020	Diagnostic Value of Serum hsa_circ_0141720 in Patients with Acute Ischemic Stroke.	hsa_circ_0142034				cerebral infarction	MONDO:0002679	cerebral infarction	down-regulated	Microarray	"hsa_circ_0142034 was identified by microarray as a down-regulated serum circRNA in ACI patients. Its disease association was not individually validated by reported RT-qPCR results, and functional information was limited to pathway enrichment of the differentially expressed circRNA set."	0.348
32776759	Clinical laboratory	2020	Diagnostic Value of Serum hsa_circ_0141720 in Patients with Acute Ischemic Stroke.	hsa_circ_0142255				cerebral infarction	MONDO:0002679	cerebral infarction	down-regulated	Microarray	"hsa_ circ_0142255 was identified by microarray as a down-regulated serum circRNA in ACI patients. Its disease association was not individually validated by reported RT-qPCR results, and functional information was limited to pathway enrichment of the differentially expressed circRNA set."	0.348
32776759	Clinical laboratory	2020	Diagnostic Value of Serum hsa_circ_0141720 in Patients with Acute Ischemic Stroke.	hsa_circ_0142089				cerebral infarction	MONDO:0002679	cerebral infarction	down-regulated	Microarray	"hsa_circ_0142089 was identified by microarray as a down-regulated serum circRNA in ACI patients. Its disease association was not individually validated by reported RT-qPCR results, and functional information was limited to pathway enrichment of the differentially expressed circRNA set."	0.348
32776759	Clinical laboratory	2020	Diagnostic Value of Serum hsa_circ_0141720 in Patients with Acute Ischemic Stroke.	hsa_circ_0006859				cerebral infarction	MONDO:0002679	cerebral infarction	down-regulated	Microarray	"hsa_circ_ 00068 59 was identified by microarray as a down-regulated serum circRNA in ACI patients. Its disease association was not individually validated by reported RT-qPCR results, and functional information was limited to pathway enrichment of the differentially expressed circRNA set."	0.348
32782707	International journal of clinical and experimental pathology	2020	Circ_0016418 promotes melanoma development and glutamine catabolism by regulating the miR-605-5p/GLS axis.	hsa_circ_0016418	circ_0016418	hsa_circ_VASH2		melanoma	MONDO:0005105	melanoma	up-regulated	RT-qPCR	"circ_0016418 is up-regulated in melanoma tissues and cells. It promotes melanoma development, including proliferation, migration, invasion, tumor growth, and glutamine catabolism, by functioning as a ceRNA for miR-605-5p and increasing GLS expression. Knockdown of circ_0016418 suppresses tumor growth in vivo and may represent a potential therapeutic strategy."	0.7183
32842350	Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology	2020	[Effect of circular RNA hsa_circ_0008898 on oral squamous cell carcinoma and its mechanism].	hsa_circ_0008898				oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"hsa_circ_0008898 is up-regulated in OSCC tissues and cell lines. It functions as an oncogenic circRNA that promotes proliferation, colony formation, migration, invasion, cell cycle progression and xenograft tumor growth, at least partly through regulation of the miR-197-5p/RHOA axis. The study suggests hsa_circ_0008898 may be a potential therapeutic target for OSCC."	0.7418
32862578	Journal of B.U.ON. : official journal of the Balkan Union of Oncology	2020	Effects of CircRNA-ITCH on proliferation and apoptosis of hepatocellular carcinoma cells through inhibiting Wnt/beta-catenin signaling pathway.		circRNA-ITCH	hsa_circ_ITCH	ITCH	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"circRNA-ITCH is down-regulated in human HCC cell lines compared with normal liver cells. Its overexpression suppresses HCC cell proliferation and colony formation and promotes apoptosis, at least partly by interacting with miR-7/miR-214 and inhibiting Wnt/beta-catenin signaling with reduced beta-catenin, c-myc, and cyclinD1 activity. The study proposes circRNA-ITCH as a potential biomarker and therapeutic target for HCC."	0.528
32889894	Anti-cancer drugs	2021	"Circular RNA circ_0007142 regulates cell proliferation, apoptosis, migration and invasion via miR-455-5p/SGK1 axis in colorectal cancer."	hsa_circ_0007142	circular RNA 0007142			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0007142 is up-regulated in CRC tissues and cell lines. It promotes CRC cell proliferation, migration, invasion and xenograft tumor growth while inhibiting apoptosis, at least partly by sponging miR-455-5p and thereby regulating SGK1. The study suggests the circ_0007142/miR-455-5p/SGK1 axis as a potential therapeutic target for CRC."	0.7591
32894542	European review for medical and pharmacological sciences	2020	Circular RNA circ-MTO1 serves as a novel potential diagnostic and prognostic biomarker for gallbladder cancer.		circular-mitochondrial translation optimization 1 / circ-MTO1	hsa_circ_MTO1		gallbladder cancer	MONDO:0003220	gallbladder carcinoma	up-regulated	RT-qPCR	"This study found that circ-MTO1 is significantly upregulated in gallbladder cancer tissues and patient plasma. Its high expression is associated with adverse clinicopathological features and shorter OS and PFS, supporting circ-MTO1 as a potential diagnostic and prognostic biomarker for GBC."	0.4992
32894545	European review for medical and pharmacological sciences	2020	Effects of circRNA_103993 on the proliferation and apoptosis of NSCLC cells through miR-1271/ERG signaling pathway.		CircRNA_103993			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"CircRNA_103993 is up-regulated in human NSCLC cell lines compared with bronchial epithelial control cells. Functionally, it promotes NSCLC cell proliferation and suppresses apoptosis. Mechanistically, CircRNA_103993 acts as a ceRNA/sponges miR-1271 to regulate ERG signaling, suggesting potential value as a molecular marker and therapeutic target."	0.5554
32896523	Brain research	2020	"Knockdown of circ0082374 inhibits cell viability, migration, invasion and glycolysis in glioma cells by miR-326/SIRT1."	hsa_circ_0082374	circ0082374	hsa_circ_CPA4	CPA4	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ0082374 is up-regulated in glioma tissues and cell lines, and high expression is associated with advanced stage and poor overall survival. Functionally, circ0082374 promotes glioma cell viability, migration, invasion, glycolysis and xenograft tumor growth. Mechanistically, it acts as a cytoplasmic ceRNA that sponges miR-326 to increase SIRT1 expression."	0.8562
32902223	Clinical laboratory	2020	Circulating circRNA Has_Circ_0141633 Serves as a Potential Biomarker for Gastric Cancer.	hsa_circ_0141633				gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"This clinical study found that has_circ_0141633 is up-regulated in both serum and tissues of gastric cancer patients. Serum has_circ_0141633 showed diagnostic potential for GC and correlated positively with tissue levels, while high expression was associated with malignant clinicopathological features and poorer survival. No molecular mechanism or regulatory axis was experimentally investigated."	0.4992
32913545	American journal of translational research	2020	Circ_0007142/miR-186/FOXK1 axis promoted lung adenocarcinoma progression.	hsa_circ_0007142	Circ_0007142			lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circ_0007142 is up-regulated in lung adenocarcinoma tissues and cell lines and is associated with advanced disease features and poor overall survival. Functionally, circ_0007142 promotes proliferation, migration, invasion and metastasis and suppresses apoptosis. Mechanistically, it acts through the miR-186/FOXK1 axis to activate the Wnt/beta-catenin signaling pathway."	0.7631
32922589	International journal of clinical and experimental pathology	2020	Genome-wide analysis of circular RNA expression profiles in patients with atrial fibrillation.	hsa_circ_0008737	circRNA_0031			atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	up-regulated	RT-qPCR; Microarray	"circRNA_0031 is an up-regulated circRNA in peripheral blood monocytes from AF patients. Its disease association was supported by microarray screening and qRT-PCR validation, but no circRNA-specific downstream mechanism was experimentally confirmed."	0.4032
32922589	International journal of clinical and experimental pathology	2020	Genome-wide analysis of circular RNA expression profiles in patients with atrial fibrillation.		circRNA_1837			atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	up-regulated	RT-qPCR; Microarray	"circRNA_1837 is up-regulated in peripheral blood monocytes from AF patients. Its altered expression was validated by qRT-PCR, while specific functional experiments or downstream targets were not reported."	0.4032
32922589	International journal of clinical and experimental pathology	2020	Genome-wide analysis of circular RNA expression profiles in patients with atrial fibrillation.	hsa_circ_0001240	circRNA_5901			atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	up-regulated	RT-qPCR; Microarray	"circRNA_5901, also identified as hsa_circ_0001240, is up-regulated in AF patient peripheral blood monocytes. The finding was validated by qRT-PCR, but the study did not experimentally define a circRNA-specific mechanistic axis."	0.4032
32922589	International journal of clinical and experimental pathology	2020	Genome-wide analysis of circular RNA expression profiles in patients with atrial fibrillation.		circRNA_7571			atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	up-regulated	RT-qPCR; Microarray	"circRNA_7571 is up-regulated in AF peripheral blood monocytes and was validated by qRT-PCR. It was also one of the four largest circRNA nodes in the predicted circRNA-miRNA co-expression network, suggesting a possible role in AF through miRNA-related regulation."	0.4032
32922589	International journal of clinical and experimental pathology	2020	Genome-wide analysis of circular RNA expression profiles in patients with atrial fibrillation.	hsa_circ_0062426	circRNA_5801			atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	down-regulated	RT-qPCR; Microarray	"circRNA_5801, also identified as hsa_circ_0062426, is down-regulated in AF peripheral blood monocytes. The expression change was supported by both microarray and qRT-PCR validation, with no circRNA-specific mechanism experimentally established."	0.4032
32922589	International journal of clinical and experimental pathology	2020	Genome-wide analysis of circular RNA expression profiles in patients with atrial fibrillation.		circRNA_7386			atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	down-regulated	RT-qPCR; Microarray	"circRNA_7386 is down-regulated in AF patient peripheral blood monocytes. Its expression change was validated by qRT-PCR, but the article did not report a specific downstream miRNA, gene, or pathway for this circRNA."	0.4032
32922589	International journal of clinical and experimental pathology	2020	Genome-wide analysis of circular RNA expression profiles in patients with atrial fibrillation.	hsa_circ_0006109	circRNA_7577			atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	down-regulated	RT-qPCR; Microarray	"circRNA_7577, also identified as hsa_circ_0006109, is down-regulated in AF peripheral blood monocytes. The expression alteration was confirmed by qRT-PCR, but no specific molecular target or functional phenotype was tested."	0.4032
32922589	International journal of clinical and experimental pathology	2020	Genome-wide analysis of circular RNA expression profiles in patients with atrial fibrillation.		circRNA_4648			atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	dysregulated	Microarray	"circRNA_4648 was identified as one of the four most connected circRNAs in the AF circRNA-miRNA co-expression network. Its expression direction was not specified in the provided text, and its evidence is limited to microarray and bioinformatic network analysis."	0.348
32922589	International journal of clinical and experimental pathology	2020	Genome-wide analysis of circular RNA expression profiles in patients with atrial fibrillation.		circRNA_4631			atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	dysregulated	Microarray	"circRNA_4631 was highlighted as one of the four key circRNAs with the most binding nodes in the AF circRNA-miRNA co-expression network. It was supported by microarray and bioinformatic analyses, without qRT-PCR validation reported for this specific circRNA."	0.348
32922589	International journal of clinical and experimental pathology	2020	Genome-wide analysis of circular RNA expression profiles in patients with atrial fibrillation.		circRNA_2875			atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	dysregulated	Microarray	"circRNA_2875 was reported as one of the four most connected circRNAs in the AF circRNA-miRNA co-expression network. The study suggests it may be a key circRNA in AF, but only microarray and bioinformatic evidence were reported for this circRNA."	0.348
32932275	Anti-cancer drugs	2021	Circ_0074027 contributes to the progression of non-small cell lung cancer via microRNA-362-3p/clathrin heavy chain axis.	hsa_circ_0074027	circ_0074027	hsa_circ_PITX1	PITX1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0074027 is up-regulated in NSCLC tissues and cell lines and is associated with low differentiation grade and advanced TNM stage. It promotes NSCLC cell proliferation, colony formation, migration, invasion and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ_0074027 acts as a miR-362-3p sponge to increase CLTC expression, forming a circ_0074027/miR-362-3p/CLTC regulatory axis."	0.7416
32940043	Neoplasma	2021	Circ_0086720 knockdown strengthens the radiosensitivity of non-small cell lung cancer via mediating the miR-375/SPIN1 axis.	hsa_circ_0086720	circRNA_104763	hsa_circ_UBAP2	UBAP2	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0086720 is up-regulated in NSCLC and particularly in radioresistant NSCLC tissues. Its knockdown increases NSCLC radiosensitivity by reducing cell survival and tumor growth and inducing apoptosis. Mechanistically, circ_0086720 acts through the miR-375/SPIN1 axis, consistent with a ceRNA-type regulatory mechanism."	0.7277
32945521	Oncology reports	2020	Propofol suppresses gastric cancer tumorigenesis by modulating the circular RNA_PVT1/miR_195_5p/E26 oncogene homolog 1 axis.		circular RNA-PVT1 / circ-PVT1	hsa_circ_PVT1	PVT1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"Circ-PVT1 is upregulated in gastric cancer tissues and cell lines. Functionally, circ-PVT1 counteracts propofol-induced suppression of proliferation and invasion and induction of apoptosis, while circ-PVT1 knockdown enhances the anti-tumor effect of propofol in vivo. Mechanistically, circ-PVT1 sponges miR-195-5p to modulate ETS1 expression in the circ-PVT1/miR-195-5p/ETS1 axis."	0.6536
32964973	European review for medical and pharmacological sciences	2020	CircRNA_100782 promotes roliferation and metastasis of gastric cancer by downregulating tumor suppressor gene Rb by adsorbing miR-574-3p in a sponge form.		circRNA_100782			gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"circRNA_100782 is significantly downregulated in gastric cancer tissues and SGC-7901 cells. Functional assays indicate that restoring circRNA_100782 suppresses gastric cancer cell proliferation, migration and invasion, while knockdown has the opposite effect. Mechanistically, circRNA_100782 acts as a miR-574-3p sponge/ceRNA to modulate Rb expression, and low circRNA_100782 expression is associated with poor prognosis."	0.6987
32964974	European review for medical and pharmacological sciences	2020	Effect of hsa_circ_RNA0023397 regulation of miR-106b expression on proliferation and apoptosis of esophageal cancer cells.	hsa_circ_0023397				esophageal cancer	MONDO:0007576	esophageal cancer	down-regulated	RT-qPCR	"hsa_circ_RNA0023397 is down-regulated in human esophageal cancer cell lines compared with normal esophageal epithelial cells. Functional assays showed that hsa_circ_RNA0023397 overexpression suppresses KYSE-150 cell proliferation and colony formation while promoting apoptosis. Mechanistically, the study supports that hsa_circ_RNA0023397 acts as a sponge for miR-106b, contributing to inhibition of esophageal cancer cell proliferation."	0.5554
32975228	Journal of biosciences	2020	Downregulation of hsa_circ_0000936 sensitizes resistant glioma cells to temozolomide by sponging miR-1294.	hsa_circ_0000936	circ-SHKBP1	hsa_circ_SHKBP1	SHKBP1	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"hsa_circ_0000936 is upregulated in glioma tissues, especially in tissues from patients resistant to temozolomide, and is also elevated in TMZ-resistant glioma cell lines. Functionally, hsa_circ_0000936 promotes TMZ resistance and suppresses apoptosis under TMZ treatment by sponging miR-1294; its knockdown sensitizes resistant glioma cells to TMZ."	0.6369
33015774	European review for medical and pharmacological sciences	2020	The circular RNA circPTK2 inhibits EMT in hepatocellular carcinoma by acting as a ceRNA and sponging miR-92a to upregulate E-cadherin.	hsa_circ_0008305	circPTK2	hsa_circ_PTK2	PTK2	Hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	unknown	RT-qPCR	"This study identifies circPTK2, also named hsa_circ_0008305, as a suppressive circRNA in HCC cell invasion, EMT, progression, and metastasis. Mechanistically, circPTK2 acts as a ceRNA that binds miR-92a and relieves miR-92a-mediated repression of E-cadherin, forming the circPTK2/miR-92a/E-cadherin axis."	0.5416
33015789	European review for medical and pharmacological sciences	2020	"Clinical significance of circ-MTHFD2 in diagnosis, pathological staging and prognosis of NSCLC."		circ-MTHFD2	hsa_circ_MTHFD2	MTHFD2	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"This clinical study found that circ-MTHFD2 is up-regulated in NSCLC cancer tissues compared with adjacent tissues. Its expression is associated with diagnostic ROC performance, TNM stage, lymph node metastasis, recurrence, and poor overall survival, suggesting that circ-MTHFD2 may be a clinical biomarker for NSCLC diagnosis, staging, and prognosis."	0.5918
33015793	European review for medical and pharmacological sciences	2020	"Correlations of hsa_circ_0046264 expression with onset, pathological stage and chemotherapy resistance of lung cancer."	hsa_circ_0046264				lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0046264 is up-regulated in NSCLC tumor tissues and is associated with advanced clinicopathological features and poorer survival. Functionally, its overexpression promotes A549 cell proliferation, migration, invasion, and cisplatin resistance, with pathway enrichment implicating TGF-beta, Wnt, PI3K/Akt, and cancer signaling pathways."	0.7076
33015793	European review for medical and pharmacological sciences	2020	"Correlations of hsa_circ_0046264 expression with onset, pathological stage and chemotherapy resistance of lung cancer."	hsa_circ_0030741				lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0030741 was one of three significantly up-regulated circRNAs selected from the NSCLC expression profiling screen and was further verified by qRT-PCR. The article did not report additional clinical, functional, or mechanistic analyses for this circRNA."	0.3588
33015793	European review for medical and pharmacological sciences	2020	"Correlations of hsa_circ_0046264 expression with onset, pathological stage and chemotherapy resistance of lung cancer."	hsa_circ_0000463				lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000463 was one of three significantly up-regulated circRNAs selected from the NSCLC expression profiling screen and was further verified by qRT-PCR. The article did not report additional clinical, functional, or mechanistic analyses for this circRNA."	0.3588
33042405	American journal of translational research	2020	Overexpression of circRNA chr7:154954255-154998784+ in cancer-associated pancreatic stellate cells promotes the growth and metastasis of pancreatic cancer by targeting the miR-4459/KIAA0513 axis.		chr7:154954255-154998784+			pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; RNA-seq	"chr7:154954255-154998784+ is upregulated in cancer-associated pancreatic stellate cells and promotes pancreatic cancer cell proliferation, migration, invasion, metastasis and xenograft tumour growth. The study proposes that it functions through the miR-4459/KIAA0513 axis and may represent a therapeutic target in pancreatic cancer."	0.7628
33042427	American journal of translational research	2020	The combination of circRNA-UMAD1 and Galectin-3 in peripheral circulation is a co-biomarker for predicting lymph node metastasis of thyroid carcinoma.	hsa_circ_0001676	circRNA-UMAD1	hsa_circ_UMAD1	UM-AD1	papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; RNA-seq	"In this study, hsa_circ_0001676/circRNA-UMAD1 was up-regulated in serum and metastatic lymph node samples from PTC patients with LNM. It functions as a miR-873 sponge in a circRNA-UMAD1/miR-873/Gal3 regulatory relationship and correlates with Gal3 expression. Clinically, circRNA-UMAD1 combined with Gal3 improved ROC-based prediction of LNM in PTC patients."	0.7429
33043682	Biochemistry and cell biology = Biochimie et biologie cellulaire	2021	"Circ_0000043 promotes the proliferation, migration, invasiveness, and epithelial-mesenchymal transition in breast cancer cells via the miR-136-Smad3 axis."	hsa_circ_0000043	circRNA_0000043			breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0000043 is up-regulated in breast cancer tissues and cell lines and is associated with adverse clinicopathological features. Functionally, it promotes breast cancer cell proliferation, migration, invasion, and EMT. Mechanistically, circ_0000043 sponges miR-136 to increase Smad3 expression, forming a circ_0000043/miR-136/Smad3 regulatory axis."	0.7537
33090396	European review for medical and pharmacological sciences	2020	CircRNA ZFR stimulates the proliferation of hepatocellular carcinoma through upregulating MAP2K1.		CircRNA ZFR	hsa_circ_ZFR	ZFR	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"CircRNA ZFR is upregulated in HCC tissues and cell lines, and its higher expression is associated with more advanced tumor grading. Functionally, circRNA ZFR promotes HCC cell viability and colony formation, at least partly through upregulating MAP2K1."	0.6369
33090401	European review for medical and pharmacological sciences	2020	Circ-PRMT5 stimulates migration in esophageal cancer by binding miR-203.		circ-PRMT5	hsa_circ_PRMT5	PRMT5	esophageal cancer	MONDO:0007576	esophageal cancer	up-regulated	RT-qPCR	"circ-PRMT5 is up-regulated in esophageal cancer tissues and cell lines. It promotes migratory ability and malignant progression of esophageal cancer cells by targeting/binding miR-203, and its high expression is associated with lymphatic and distant metastasis."	0.6369
33090403	European review for medical and pharmacological sciences	2020	CircRNF20 aggravates the progression of non-small-cell lung carcinoma by activating MAPK9.		circRNF20	hsa_circ_RNF20		non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circRNF20 is up-regulated in NSCLC tissues and cell lines, correlates with advanced T stage, and high expression predicts poor prognosis. Functionally, circRNF20 promotes NSCLC cell proliferation, and its knockdown reduces cell viability and colony formation. Mechanistically, circRNF20 binds and activates MAPK9 to stimulate NSCLC proliferation."	0.7365
33099906	Journal of B.U.ON. : official journal of the Balkan Union of Oncology	2020	Circular RNA THBS1 promotes proliferation and apoptosis of non-small cell lung cancer cells by sponging miR-129-5p and regulating SOX4 expression.		circTHBS1 / circRNA thrombospondin-1	hsa_circ_THBS1	THBS1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circTHBS1 is up-regulated in NSCLC tissues and is higher in metastatic than non-metastatic NSCLC. The study indicates that circTHBS1 promotes NSCLC cell proliferation, suppresses apoptosis, and functions through a circTHBS1/miR-129-5p/SOX4 ceRNA mechanism, suggesting potential diagnostic, prognostic, and therapeutic relevance."	0.6815
33147048	Neoplasma	2021	Exosomal transfer of circular RNA FBXW7 ameliorates the chemoresistance to oxaliplatin in colorectal cancer by sponging miR-18b-5p.		circular RNA FBXW7 / Circular RNA F-box and WD repeat domain containing 7 	hsa_circ_FBXW7	FBXW7	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"circ-FBXW7 is down-regulated in oxaliplatin-resistant CRC patients and resistant CRC cells. Exosome-mediated delivery of circ-FBXW7 sensitizes resistant CRC cells and xenografts to oxaliplatin by sponging miR-18b-5p, promoting apoptosis and suppressing EMT, motility, drug efflux, and chemoresistance."	0.7045
33148890	Biological & pharmaceutical bulletin	2021	Hsa_circ_0002060 Knockdown Ameliorates Osteoporosis by Targeting MiR-198-5p.	hsa_circ_0002060				Osteoporosis / OP	MONDO:0005298	osteoporosis	up-regulated	RT-qPCR	"This study found that hsa_circ_0002060 is up-regulated in a DEX-induced osteoblast osteoporosis model and that its knockdown protects hFOB1.19 cells from viability loss, apoptosis, oxidative stress, ROS increase, and mitochondrial membrane potential reduction. Mechanistically, hsa_circ_0002060 acts through the miR-198-5p/Bax axis and JNK signaling, and its knockdown alleviates OVX-induced osteoporosis in vivo, suggesting therapeutic potential in OP."	0.6279
33155212	European review for medical and pharmacological sciences	2020	Circular RNA circ-PRKCI promotes lung cancer progression by binding to microRNA-1324 to regulate MECP2 expression.		circ-PRKCI	hsa_circ_PRKCI	PRKCI	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circ-PRKCI is up-regulated in lung cancer/lung adenocarcinoma tissues and cell lines, and high expression is associated with poor prognosis. Functionally, circ-PRKCI promotes proliferation and invasion of lung adenocarcinoma cells. Mechanistically, it mainly acts as a cytoplasmic ceRNA by binding microRNA-1324 to promote MECP2 expression."	0.7357
33165436	International journal of clinical and experimental pathology	2020	Circular RNA MGAT1 regulates cell proliferation and apoptosis in hypoxia-induced cardiomyocytes through miR-34a/YAP1 axis.	hsa_circ_0075370		hsa_circ_MGAT1	MGAT1	Congenital heart disease / CHD	MONDO:0005453	congenital heart disease	down-regulated	RT-qPCR	"circMGAT1 is down-regulated in CHD tissues and hypoxia-induced AC16 cardiomyocytes. In vitro, circMGAT1 promotes proliferation and inhibits apoptosis by sponging miR-34a and thereby regulating YAP1 expression through the miR-34a/YAP1 axis, suggesting potential therapeutic relevance for human CHD."	0.7551
33177072	Journal of investigative medicine : the official publication of the American Federation for Clinical Research	2021	Circular RNA HIPK3 plays a carcinogenic role in cervical cancer progression via regulating miR-485-3p/FGF2 axis.	hsa_circ_0000284		hsa_circ_HIPK3	HIPK3	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in cervical cancer tissues and functions as an oncogenic circRNA. It promotes cervical cancer cell proliferation, migration and invasion by sponging miR-485-3 p and indirectly increasing FGF2 expression through a ceRNA mechanism."	0.6536
33177288	Bioscience trends	2021	"Depletion of circ-BIRC6, a circular RNA, suppresses non-small cell lung cancer progression by targeting miR-4491."	hsa_circ_0003288		hsa_circ_BIRC6	BIRC6	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ-BIRC6 is upregulated in NSCLC tissues and cell lines. Its knockdown suppresses proliferation, colony formation, migration, invasion, and xenograft tumor growth while promoting apoptosis. Mechanistically, circ-BIRC6 sponges and negatively regulates miR-4491 and is linked to activation of the Wnt2B/beta-catenin pathway, suggesting therapeutic potential in NSCLC."	0.6544
33186139	Anti-cancer drugs	2021	Circ-ZNF124 downregulation inhibits non-small cell lung cancer progression partly by inactivating the Wnt/beta-catenin signaling pathway via mediating the miR-498/YES1 axis.	hsa_circ_0017348		hsa_circ_ZNF124	ZNF124	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ-ZNF124 is up-regulated in NSCLC tissues and cell lines and functions as an oncogenic circRNA. Its knockdown suppresses NSCLC proliferation, invasion and xenograft tumor growth while inducing apoptosis and cell cycle arrest. Mechanistically, circ-ZNF124 sponges miR-498 to regulate YES1 and activate the Wnt/beta-catenin signaling pathway."	0.6542
33194025	American journal of translational research	2020	Circular RNA circRPPH1 promotes triple-negative breast cancer progression via the miR-556-5p/YAP1 axis.		hsa_circRNA_001846	hsa_circ_RPPH1	RPPH1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"CircRPPH1 is up-regulated in breast cancer tissues and cell lines and functions as an oncogenic circRNA. It is mainly cytoplasmic and promotes BC cell proliferation, migration, colony formation and in vivo tumor growth by sponging miR-512-5p, thereby stabilizing/upregulating STAT1. The study suggests circRPPH1 may serve as a potential biomarker and therapeutic target for BC."	0.8511
33215421	European review for medical and pharmacological sciences	2020	"Circular RNA circGFRA1 promotes angiogenesis, cell proliferation and migration of hepatocellular carcinoma by combining with miR-149."		circGFRA1	hsa_circ_GFRA1	GFRA1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circGFRA1 is up-regulated in HCC tissues and cell lines, and high expression is associated with poor prognosis. Functionally, circGFRA1 promotes HCC cell proliferation, migration and angiogenesis. Mechanistically, circGFRA1 binds miR-149 and acts through the circGFRA1/miR-149 regulatory axis, making it a potential clinical diagnostic and therapeutic target."	0.7078
33215531	Epigenomics	2020	Building a circular RNA centered gene regulation network associated with cervical squamous cell carcinoma.	hsa_circ_0043280		hsa_circ_TADA2A	TADA2A	cervical squamous cell carcinoma / CSCC	MONDO:0006143	cervical squamous cell carcinoma	down-regulated	Microarray	hsa circ 0043280 is a downregulated CSCC-associated circRNA derived from TADA2A. The study predicts that it may act as a ceRNA by interacting with hsa-miR-638 and participate in a circRNA-miRNA-mRNA-drug/chemical regulatory network relevant to CSCC biology and therapy.	0.1768
33215531	Epigenomics	2020	Building a circular RNA centered gene regulation network associated with cervical squamous cell carcinoma.	hsa_circ_0027821		hsa_circ_RMST	RMST	cervical squamous cell carcinoma / CSCC	MONDO:0006143	cervical squamous cell carcinoma	down-regulated	Microarray	hsa circ 0027821 is a downregulated CSCC-associated circRNA derived from RMST. The study predicts that it may act as a ceRNA by interacting with hsa-miR-139-5p and participate in a circRNA-miRNA-mRNA-drug/chemical regulatory network relevant to CSCC biology and therapy.	0.1768
33215531	Epigenomics	2020	Building a circular RNA centered gene regulation network associated with cervical squamous cell carcinoma.	hsa_circ_0000745		hsa_circ_SPECC1	SPECC1	cervical squamous cell carcinoma / CSCC	MONDO:0006143	cervical squamous cell carcinoma	up-regulated	Microarray	hsa circ 0000745 is an upregulated CSCC-associated circRNA derived from SPECC1 identified by microarray-based bioinformatics analysis. No specific interaction axis or functional validation was reported for this circRNA.	0.1768
33215531	Epigenomics	2020	Building a circular RNA centered gene regulation network associated with cervical squamous cell carcinoma.	hsa_circ_0084927		hsa_circ_ESRP1	ESRP1	cervical squamous cell carcinoma / CSCC	MONDO:0006143	cervical squamous cell carcinoma	up-regulated	Microarray	hsa circ 0084927 is an upregulated CSCC-associated circRNA derived from ESRP1 identified by microarray-based bioinformatics analysis. No specific interaction axis or functional validation was reported for this circRNA.	0.1768
33215531	Epigenomics	2020	Building a circular RNA centered gene regulation network associated with cervical squamous cell carcinoma.	hsa_circ_0002762		hsa_circ_CDK17	CDK17	cervical squamous cell carcinoma / CSCC	MONDO:0006143	cervical squamous cell carcinoma	up-regulated	Microarray	hsa circ 0002762 is an upregulated CSCC-associated circRNA derived from CDK17 identified by microarray-based bioinformatics analysis. No specific interaction axis or functional validation was reported for this circRNA.	0.1768
33215531	Epigenomics	2020	Building a circular RNA centered gene regulation network associated with cervical squamous cell carcinoma.	hsa_circ_0003037		hsa_circ_TRIO	TRIO	cervical squamous cell carcinoma / CSCC	MONDO:0006143	cervical squamous cell carcinoma	up-regulated	Microarray	hsa circ 0003037 is an upregulated CSCC-associated circRNA derived from TRIO identified by microarray-based bioinformatics analysis. No specific interaction axis or functional validation was reported for this circRNA.	0.1768
33215531	Epigenomics	2020	Building a circular RNA centered gene regulation network associated with cervical squamous cell carcinoma.	hsa_circ_0031027		hsa_circ_TMCO3	TMCO3	cervical squamous cell carcinoma / CSCC	MONDO:0006143	cervical squamous cell carcinoma	down-regulated	Microarray	hsa circ 0031027 is a downregulated CSCC-associated circRNA derived from TMCO3 identified by microarray-based bioinformatics analysis. No specific interaction axis or functional validation was reported for this circRNA.	0.1768
33215531	Epigenomics	2020	Building a circular RNA centered gene regulation network associated with cervical squamous cell carcinoma.	hsa_circ_0046290		hsa_circ_ASPSCR1	ASPSCR1	cervical squamous cell carcinoma / CSCC	MONDO:0006143	cervical squamous cell carcinoma	down-regulated	Microarray	hsa circ 0046290 is a downregulated CSCC-associated circRNA derived from ASPSCR1 identified by microarray-based bioinformatics analysis. No specific interaction axis or functional validation was reported for this circRNA.	0.1768
33215531	Epigenomics	2020	Building a circular RNA centered gene regulation network associated with cervical squamous cell carcinoma.	hsa_circ_0065898		hsa_circ_VPRBP	VPRBP	cervical squamous cell carcinoma / CSCC	MONDO:0006143	cervical squamous cell carcinoma	down-regulated	Microarray	hsa circ 0065898 is a downregulated CSCC-associated circRNA derived from VPRBP identified by microarray-based bioinformatics analysis. No specific interaction axis or functional validation was reported for this circRNA.	0.1768
33215531	Epigenomics	2020	Building a circular RNA centered gene regulation network associated with cervical squamous cell carcinoma.	hsa_circ_0070190		hsa_circ_BMP2K	BMP2K	cervical squamous cell carcinoma / CSCC	MONDO:0006143	cervical squamous cell carcinoma	down-regulated	Microarray	hsa circ 0070190 is a downregulated CSCC-associated circRNA derived from BMP2K identified by microarray-based bioinformatics analysis. No specific interaction axis or functional validation was reported for this circRNA.	0.1768
33215531	Epigenomics	2020	Building a circular RNA centered gene regulation network associated with cervical squamous cell carcinoma.	hsa_circ_0058794		hsa_circ_AGAP1	AGAP1	cervical squamous cell carcinoma / CSCC	MONDO:0006143	cervical squamous cell carcinoma	down-regulated	Microarray	hsa circ 0058794 is a downregulated CSCC-associated circRNA derived from AGAP1 identified by microarray-based bioinformatics analysis. No specific interaction axis or functional validation was reported for this circRNA.	0.1768
33215531	Epigenomics	2020	Building a circular RNA centered gene regulation network associated with cervical squamous cell carcinoma.	hsa_circ_0020926		hsa_circ_STIM1	STIM1	cervical squamous cell carcinoma / CSCC	MONDO:0006143	cervical squamous cell carcinoma	down-regulated	Microarray	hsa circ 0020926 is a downregulated CSCC-associated circRNA derived from STIM1 identified by microarray-based bioinformatics analysis. No specific interaction axis or functional validation was reported for this circRNA.	0.1768
33215531	Epigenomics	2020	Building a circular RNA centered gene regulation network associated with cervical squamous cell carcinoma.	hsa_circ_0000301		hsa_circ_SPI1	SPI1	cervical squamous cell carcinoma / CSCC	MONDO:0006143	cervical squamous cell carcinoma	down-regulated	Microarray	hsa circ 0000301 is a downregulated CSCC-associated circRNA derived from SPI1 identified by microarray-based bioinformatics analysis. No specific interaction axis or functional validation was reported for this circRNA.	0.1768
33215531	Epigenomics	2020	Building a circular RNA centered gene regulation network associated with cervical squamous cell carcinoma.	hsa_circ_0000077		hsa_circ_TM2D1	TM2D1	cervical squamous cell carcinoma / CSCC	MONDO:0006143	cervical squamous cell carcinoma	down-regulated	Microarray	hsa circ 0000077 is a downregulated CSCC-associated circRNA derived from TM2D1 identified by microarray-based bioinformatics analysis. No specific interaction axis or functional validation was reported for this circRNA.	0.1768
33252475	Neuroreport	2021	"Lidocaine inhibits glioma cell proliferation, migration and invasion by modulating the circEZH2/miR-181b-5p pathway."	hsa_circ_0082846		hsa_circ_EZH2	EZH2	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circEZH2 is up-regulated in glioma tissues and cells and its expression increases with glioma grade. Functionally, circEZH2 promotes malignant glioma behaviors and antagonizes lidocaine-mediated inhibition of proliferation, migration, invasion and tumor growth. Mechanistically, circEZH2 sponges miR-181b-5p as part of the circEZH2/miR-181b-5p regulatory pathway."	0.7045
33275224	European review for medical and pharmacological sciences	2020	Circ_0005273 induces the aggravation of pancreatic cancer by targeting KLF12.	hsa_circ_0005273				pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"circ_0005273 is up-regulated in pancreatic cancer tissues and cell lines. It promotes pancreatic cancer cell proliferation and migration, and its high expression is associated with lymphatic metastasis, distant metastasis, worse survival and diagnostic potential. Mechanistically, the study reports that circ_0005273 binds to and regulates KLF12 in a circ_0005273-KLF12 axis."	0.7513
33275225	European review for medical and pharmacological sciences	2020	Characteristics and prognostic significance of circRNA-100876 in patients with colorectal cancer.		circRNA-100876			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circRNA-100876 is up-regulated in colorectal cancer tissues and cell lines. High circRNA-100876 expression is associated with advanced clinicopathological features and poor overall survival, while siRNA-mediated knockdown reduces colorectal cancer cell invasion. The study supports circRNA-100876 as a tumor-promoting circRNA and potential diagnostic or therapeutic target in colorectal cancer."	0.5736
33284888	International journal of clinical and experimental pathology	2020	Construction of ceRNA network and identification of two differentially expressed circRNAs in hepatocellular carcinoma by bioinformatic analysis.	hsa_circ_0007813				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RNA-seq	"hsa_circ_0007813 was identified as an up-regulated HCC-related circRNA by bioinformatic reanalysis of GEO RNA-seq datasets. The study proposes that it may function as a ceRNA by binding hsa_miR_139-5p and regulating 80 DEmRNAs, with possible relevance to HCC occurrence, progression, and diagnosis."	0.348
33284888	International journal of clinical and experimental pathology	2020	Construction of ceRNA network and identification of two differentially expressed circRNAs in hepatocellular carcinoma by bioinformatic analysis.	hsa_circ_0089372				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RNA-seq	"hsa_circ_0089372 was identified as a down-regulated HCC-related circRNA by bioinformatic reanalysis of GEO RNA-seq datasets. The study proposes that it may function as a ceRNA by binding hsa_miR_346 and regulating 18 DEmRNAs, with possible relevance to HCC occurrence, progression, and diagnosis."	0.348
33284890	International journal of clinical and experimental pathology	2020	"Circular RNA circ_ASAP2 promotes cell viability, migration, and invasion of gastric cancer cells by regulating the miR-770-5p/CDK6 axis."	hsa_circ_0008768	circ_ASAP2	hsa_circ_ASAP2	ASAP2	Gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circ_ASAP2 is up-regulated in gastric cancer tissues and cell lines. It promotes GC cell viability, migration, invasion, and xenograft tumor growth by sponging miR-770-5p and positively regulating CDK6, suggesting potential therapeutic relevance."	0.7404
33287917	"Cellular and molecular biology (Noisy-le-Grand, France)"	2020	"CircB3GNTL1 and miR-598 regulation effects on proliferation, apoptosis, and glutaminolysis in gastric cancer cells."		circB3GNTL1	hsa_circ_B3GNTL1	B3GNTL1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"This study reports that circB3GNTL1 is up-regulated in gastric cancer tissues and AGS gastric cancer cells. Functional knockdown experiments indicate that circB3GNTL1 promotes gastric cancer cell proliferation and glutamine decomposition/glutaminolysis while inhibiting apoptosis, at least partly through targeting and regulating miR-598."	0.7372
33294264	American journal of cancer research	2020	Circ-EEF2 facilitated autophagy via interaction with mir-6881-3p and ANXA2 in EOC.	hsa_circ_0048559	circEEF2	hsa_circ_EEF2	EEF2	epithelial ovarian cancer / EOC	MONDO:0005140	ovarian carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"CircEEF2 is up-regulated in epithelial ovarian cancer tissues and is associated with advanced FIGO stage and higher tumor grade. Functionally, it promotes autophagy-driven proliferation, invasion, xenograft tumor growth, and metastasis, mainly by sponging miR-6881-3p to increase ATG5/ATG7 and by binding ANXA2 to suppress p-mTOR activation. The study suggests circEEF2 as a potential biomarker and therapeutic target for ovarian cancer."	0.8502
33298736	Journal of cardiovascular pharmacology	2021	Circular RNA Circ-BANP Regulates Oxidized Low-density Lipoprotein-induced Endothelial Cell Injury Through Targeting the miR-370/Thioredoxin-interacting Protein Axis.	hsa_circ_0040824	circ-BANP	hsa_circ_BANP	BANP	atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"This study identifies circ-BANP/hsa_circ_0040824 as an up-regulated human circRNA in AS blood and ox-LDL-treated endothelial cells. Circ-BANP aggravates ox-LDL-induced HUVEC injury by directly targeting miR-370 and relieving miR-370-mediated repression of TXNIP, while circ-BANP silencing improves endothelial cell viability, reduces inflammation and apoptosis, and restores migration, invasion and tube formation."	0.742
33312376	American journal of translational research	2020	Plasma circular RNA panel acts as a novel diagnostic biomarker for colorectal cancer detection.	hsa_circ_0001900	hsa_circRNA_104962	hsa_circ_CAMSAP1	CAMSAP1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001900 is upregulated in plasma and CRC tumor tissues of CRC patients. It was validated by qRT-PCR and Sanger sequencing and showed diagnostic utility for distinguishing CRC from non-CRC samples, especially as part of the three-circRNA CircPanel."	0.63
33312376	American journal of translational research	2020	Plasma circular RNA panel acts as a novel diagnostic biomarker for colorectal cancer detection.	hsa_circ_0001178	hsa_circRNA_103112	hsa_circ_USP25	USP25	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001178 is upregulated in plasma and CRC tumor tissues of CRC patients. It was validated by qRT-PCR and Sanger sequencing, associated with metastatic clinicopathological features, and contributed to a diagnostic CircPanel for CRC detection."	0.63
33312376	American journal of translational research	2020	Plasma circular RNA panel acts as a novel diagnostic biomarker for colorectal cancer detection.	hsa_circ_0005927	hsa_circRNA_104600	hsa_circ_VDAC3	VDAC3	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0005927 is upregulated in plasma and CRC tumor tissues of CRC patients. It showed the highest individual AUC among the three validated circRNAs and contributed to a plasma CircPanel proposed for CRC diagnosis, including CEA-negative CRC detection."	0.63
33325363	Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology	2020	[Over-expression of circNR4A1/Hsa-circ-0026352 inhibits proliferation and induces apoptosis in MCF-7 cells].	hsa_circ_0026352	circNR4A1	hsa_circ_NR4A1	N£Ò4A1	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	"circN£Ò4A1/Hsa-circ-0026352 is down-regulated in breast cancer tissues, patient peripheral blood, and breast cancer cell lines. Its overexpression in MCF-7 cells suppresses proliferation and colony formation, arrests the cell cycle at G1/S, and promotes apoptosis, likely involving inhibition of the K-RAS/MEK/ERK pathway and modulation of apoptosis-related proteins. The study suggests circN£Ò4A1 may serve as a diagnostic biomarker and potential therapeutic target in breast cancer."	0.697
33330860	bioRxiv : the preprint server for biology	2020	"Circular RNA profiling reveals abundant and diverse circRNAs of SARS-CoV-2, SARS-CoV and MERS-CoV origin."		SARS-CoV-2_29122|29262 / circRNA 29122|28295			SARS-CoV-2 infection / COVID-19	MONDO:0100096	COVID-19	up-regulated	RT-qPCR; RNA-seq	This SARS-CoV-2-derived circRNA was the most abundant predicted SARS-CoV-2 circRNA and was experimentally detected in infected Vero E6 cells. The study suggests it is part of the diverse coronavirus circRNA transcriptome and may reflect infection-stage-dependent viral circRNA expression.	0.4276
33330860	bioRxiv : the preprint server for biology	2020	"Circular RNA profiling reveals abundant and diverse circRNAs of SARS-CoV-2, SARS-CoV and MERS-CoV origin."		29194|27797			SARS-CoV-2 infection / COVID-19	MONDO:0100096	COVID-19	up-regulated	RT-qPCR; RNA-seq	29194|27797 is a SARS-CoV-2-derived circRNA experimentally confirmed by inverse RT-PCR and Sanger sequencing in infected Vero E6 cells. It was described as highly expressed among confirmed SARS-CoV-2 circRNA clones.	0.4276
33330860	bioRxiv : the preprint server for biology	2020	"Circular RNA profiling reveals abundant and diverse circRNAs of SARS-CoV-2, SARS-CoV and MERS-CoV origin."		28853|28467			SARS-CoV-2 infection / COVID-19	MONDO:0100096	COVID-19	up-regulated	RT-qPCR; RNA-seq	28853|28467 is a SARS-CoV-2-derived circRNA experimentally confirmed by inverse RT-PCR and Sanger sequencing in infected Vero E6 cells. It was described as highly expressed among confirmed SARS-CoV-2 circRNA clones.	0.4276
33330860	bioRxiv : the preprint server for biology	2020	"Circular RNA profiling reveals abundant and diverse circRNAs of SARS-CoV-2, SARS-CoV and MERS-CoV origin."		SARS-CoV_28136|28606			SARS-CoV-2 infection / COVID-19	MONDO:0100096	COVID-19	up-regulated	RNA-seq	SARS-CoV_28136|28606 was the most abundant SARS-CoV-derived circRNA detected in the authors' bioinformatic analysis of SARS-CoV infection-related RNA-seq data. Its functional role was not experimentally tested.	0.1768
33330860	bioRxiv : the preprint server for biology	2020	"Circular RNA profiling reveals abundant and diverse circRNAs of SARS-CoV-2, SARS-CoV and MERS-CoV origin."		MERS-CoV_1503|29952			MERS-CoV infection	MONDO:0100116	Middle East respiratory syndrome	up-regulated	RNA-seq	MERS-CoV_1503|29952 was the most abundant MERS-CoV-derived circRNA detected in the authors' bioinformatic analysis of MERS-CoV infection-related RNA-seq data. Its functional role was not experimentally tested.	0.1768
33334787	Annals of clinical and laboratory science	2020	circ_0067934: A Potential Biomarker and Therapeutic Target for Hepatocellular Carcinoma.	hsa_circ_0067934	circ_0067934			Hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"This clinical study found that circ_0067934 is significantly up-regulated in HCC tissues compared with adjacent non-tumor tissues. Higher circ_0067934 expression correlated with tumor size, TNM stage, microvascular invasion, diagnostic performance by ROC analysis, and poorer prognosis, supporting its potential value as a diagnostic and prognostic biomarker for HCC."	0.4992
33336726	European review for medical and pharmacological sciences	2020	Circular RNA circ_0000034 upregulates STX17 level to promote human retinoblastoma development via inhibiting miR-361-3p.	hsa_circ_0000034	circ_0000034			retinoblastoma / RB	MONDO:0008380	retinoblastoma	up-regulated	RT-qPCR	"circ_0000034 is up-regulated in retinoblastoma tissues and cells and is associated with poorer patient survival. Functionally, circ_0000034 promotes RB cell proliferation, migration, invasion, autophagy and xenograft tumor growth while suppressing apoptosis. Mechanistically, it targets miR-361-3p and relieves miR-361-3p-mediated repression of STX17, forming a circ_0000034/miR-361-3p/STX17 regulatory axis."	0.8001
33336739	European review for medical and pharmacological sciences	2020	Circ-ABCB10 promotes growth and metastasis of nasopharyngeal carcinoma by upregulating ROCK1.	hsa_circ_0008717	circ-ABCB10	hsa_circ_ABCB10	ABCB10	Nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"circ-ABCB10 (hsa_circ_0008717) is upregulated in nasopharyngeal carcinoma tissues and cell lines. The study indicates that circ-ABCB10 acts as an oncogenic circRNA that promotes NPC cell proliferation, cell cycle progression, migration, invasion and metastasis, at least partly by upregulating ROCK1. Its higher expression is associated with tumor size and lymphatic metastasis, suggesting potential clinical biomarker value."	0.5761
33336740	European review for medical and pharmacological sciences	2020	CircRNA_100395 protects breast carcinoma deterioration by targeting MAPK6.		circRNA_100395			breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	"CircRNA_100395 is downregulated in breast carcinoma tissues and cell lines. It functions as an anti-cancer circRNA by suppressing breast carcinoma cell proliferation, colony formation and migration, at least partly through targeting and negatively regulating MAPK6. Its reduced expression is clinically associated with larger tumor size and more advanced tumor staging, supporting potential biomarker and therapeutic relevance."	0.6536
33336744	European review for medical and pharmacological sciences	2020	"Hsa_circ_0000337 promotes proliferation, migration and invasion in glioma by competitively binding miRNA-942-5p and thus upregulates MAT2A."	hsa_circ_0000337		hsa_circ_PPFIA1	PPFIA1	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"hsa_circ_0000337 is upregulated in glioma tissues and cell lines, and its high expression is associated with advanced tumor stage and poor overall survival. Functionally, hsa_circ_0000337 promotes glioma cell proliferation, migration and invasion. Mechanistically, it acts as a ceRNA by sponging miRNA-942-5p, thereby upregulating MAT2A and promoting malignant glioma progression."	0.8271
33337836	Clinical laboratory	2020	Three CircRNAs Function as Potential Biomarkers for Colorectal Cancer.		circ-FMN2	hsa_circ_FMN2	FMN2	Colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ-FMN2 was significantly up-regulated in serum samples from CRC patients. Its higher expression was associated with advanced clinicopathological features and poorer overall survival, supporting its potential as a diagnostic and prognostic biomarker for CRC."	0.4758
33337836	Clinical laboratory	2020	Three CircRNAs Function as Potential Biomarkers for Colorectal Cancer.		circ-LMNB1	hsa_circ_LMNB1	LMNB1	Colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ-LMNB1 was significantly up-regulated in serum samples from CRC patients. Its higher expression was associated with advanced clinicopathological features and poorer overall survival, supporting its potential as a diagnostic and prognostic biomarker for CRC."	0.4758
33337836	Clinical laboratory	2020	Three CircRNAs Function as Potential Biomarkers for Colorectal Cancer.		circ-ZNF609	hsa_circ_ZNF609	ZNF609	Colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ-ZNF609 was significantly up-regulated in serum samples from CRC patients. Its higher expression was associated with advanced clinicopathological features and poorer overall survival, supporting its potential as a diagnostic and prognostic biomarker for CRC."	0.4758
33348975	Journal of biological regulators and homeostatic agents	2020	HSA_CIRC_0004050 on proliferation and apoptosis of A549 cells through ERK/JNK signaling pathway.	hsa_circ_0004050				non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0004050 is down-regulated in NSCLC tissues and A549 cells and acts as a tumor suppressor. It sponges miR-1233-3p to increase DUSP9 expression, thereby inhibiting ERK/JNK signaling, suppressing proliferation and promoting apoptosis. Clinically, higher hsa_circ_0004050 expression is associated with longer survival and may have diagnostic or therapeutic biomarker potential."	0.8057
33378035	European review for medical and pharmacological sciences	2020	Circular RNA circHIPK3 as a novel circRNA regulator of autophagy and endothelial cell dysfunction in atherosclerosis.		circHIPK3	hsa_circ_HIPK3	HIPK3	atherosclerosis / AS	MONDO:0005311	atherosclerosis	down-regulated	RT-qPCR	"circHIPK3 is downregulated in HFD-induced atherosclerotic mice and ox-LDL-treated HUVECs. Its overexpression promotes autophagy and reduces lipid accumulation, apparently through direct targeting of the miR-190b/ATG7 axis, suggesting a protective role in atherosclerosis-related endothelial dysfunction."	0.627
33378035	European review for medical and pharmacological sciences	2020	Circular RNA circHIPK3 as a novel circRNA regulator of autophagy and endothelial cell dysfunction in atherosclerosis.		circHIPK3	mmu_circ_HIPK3	HIPK3	atherosclerosis / AS	MONDO:0005311	atherosclerosis	down-regulated	RT-qPCR	"circHIPK3 is downregulated in HFD-induced atherosclerotic mice and ox-LDL-treated HUVECs. Its overexpression promotes autophagy and reduces lipid accumulation, apparently through direct targeting of the miR-190b/ATG7 axis, suggesting a protective role in atherosclerosis-related endothelial dysfunction."	0.627
33398368	Molecular medicine reports	2021	circFOXO3 protects cardiomyocytes against radiation_induced cardiotoxicity.	hsa_circ_0006404	circFOXO3	hsa_circ_FOXO3	FOXO3	radiation-induced cardiotoxicity	MONDO:0043459	radiation-induced disorder	up-regulated	RT-qPCR	"circFOXO3 is up-regulated in irradiated human AC16 cardiomyocytes and acts protectively against radiation-induced cardiotoxicity. Knockdown increases DNA damage and apoptosis, while overexpression reduces these effects by suppressing pro-apoptotic Bax, caspase 3 and caspase 7 and increasing anti-apoptotic Bcl-2. The study suggests circFOXO3 as a potential therapeutic target for radiation-induced cardiotoxicity."	0.4469
33415005	American journal of cancer research	2020	Downregulation of circ-TRPS1 suppressed prostatic cancer prognoses by regulating miR-124-3p/EZH2 axis-mediated stemness.	hsa_circ_0006950	circ-TRPS1	hsa_circ_TRPS1	TRPS1	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circ-TRPS1 is up-regulated in high-grade prostate cancer tissues and PCa cell lines, and high expression is associated with aggressive clinicopathologic features and poor prognosis. Functionally, circ-TRPS1 promotes PCa proliferation, migration, invasion, metastasis, and cancer stem-like cell differentiation by sponging miR-124-3p and increasing EZH2 expression. Its knockdown suppresses tumor growth and metastasis in vitro and in vivo, supporting circ-TRPS1 as a potential therapeutic target."	0.8439
33417289	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2021	Silencing of circIgf1r plays a protective role in neuronal injury via regulating astrocyte polarization during epilepsy.		circIgf1r	mmu_circ_Igf1r	Igf1r	epilepsy	MONDO:0005027	epilepsy	up-regulated	RT-qPCR; RNA-seq	"circIgf1r is upregulated in a 4-AP-induced mouse status epilepticus model and in 4-AP-treated primary astrocytes. The study shows that circIgf1r aggravates epilepsy-associated neuronal injury by promoting neurotoxic A1 astrocyte polarization through inhibition of autophagy, while circIgf1r knockdown shifts astrocytes toward the protective A2 phenotype, restores autophagy flux, reduces neuronal toxicity, and alleviates seizure severity."	0.6649
33425100	International journal of clinical and experimental pathology	2020	Cyclic RNA Circ_0000735 sponges miR-502-5p to promote bladder cancer cell proliferation and invasion and inhibit apoptosis.	hsa_circ_0000735	Circ_0000735	hsa_circ_P2RX1	P2RX1	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"Circ_0000735 is up-regulated in bladder cancer tissues and cell lines. It promotes bladder cancer cell proliferation, invasion and xenograft tumorigenesis while inhibiting apoptosis, at least partly by acting as a cytoplasmic ceRNA that sponges miR-502-5p. The study suggests Circ_0000735 may be a potential therapeutic target for bladder cancer."	0.7785
33432632	Artificial organs	2021	Differential expression profiles of circular RNAs in the rat hippocampus after deep hypothermic circulatory arrest.		rno_circRNA_011190	rno_circ_Magi2	Magi2	deep hypothermic circulatory arrest-associated brain injury	MONDO:0043510	brain injury	up-regulated	RT-qPCR; Microarray	"rno_circRNA_011190 was significantly up-regulated in rat hippocampus after DHCA and validated by RT-qPCR. The study predicts that it may act through a ceRNA mechanism involving target miRNAs and mRNAs such as MASP-2, PON-3 and Tp53, potentially contributing to DHCA-related brain injury."	0.5608
33432632	Artificial organs	2021	Differential expression profiles of circular RNAs in the rat hippocampus after deep hypothermic circulatory arrest.		rno_circRNA_012988	rno_circ_LOC366300	LOC366300	deep hypothermic circulatory arrest-associated brain injury	MONDO:0043510	brain injury	up-regulated	RT-qPCR; Microarray	"rno_circRNA_012988 was significantly up-regulated in rat hippocampus after DHCA and validated by RT-qPCR. The study predicts that it may participate in DHCA-associated brain injury through circRNA-miRNA-mRNA ceRNA networks and enriched pathways including histidine metabolism, adipocytokine signaling and cAMP signaling."	0.5608
33432632	Artificial organs	2021	Differential expression profiles of circular RNAs in the rat hippocampus after deep hypothermic circulatory arrest.		rno_circRNA_000544	rno_circ_Ipo7	Ipo7	deep hypothermic circulatory arrest-associated brain injury	MONDO:0043510	brain injury	up-regulated	RT-qPCR; Microarray	rno_circRNA_000544 was significantly up-regulated in rat hippocampus after DHCA and validated by RT-qPCR. The authors propose that it may participate in DHCA-associated brain injury through a ceRNA-like rno-circRNA-000544/miR-194-5p/SUMO2 axis.	0.5608
33432632	Artificial organs	2021	Differential expression profiles of circular RNAs in the rat hippocampus after deep hypothermic circulatory arrest.		rno_circRNA_010393	rno_circ_Ppp1r16b	Ppp1r16b	deep hypothermic circulatory arrest-associated brain injury	MONDO:0043510	brain injury	down-regulated	RT-qPCR; Microarray	rno_circRNA_010393 was significantly down-regulated in rat hippocampus after DHCA and validated by RT-qPCR. The study predicts that it may be involved in DHCA-related brain injury through ceRNA regulation of Tp53 and may also participate in metabolic regulation through predicted relationships with Yap1 and Fabp3.	0.5608
33432632	Artificial organs	2021	Differential expression profiles of circular RNAs in the rat hippocampus after deep hypothermic circulatory arrest.		rno_circRNA_012043	rno_circ_Grm8	Grm8	deep hypothermic circulatory arrest-associated brain injury	MONDO:0043510	brain injury	down-regulated	RT-qPCR; Microarray	rno_circRNA_012043 was significantly down-regulated in rat hippocampus after DHCA and validated by RT-qPCR. The study predicts that it may sponge several miRNAs to regulate CREB3 and may be connected to the cAMP-PKA-CREB pathway in DHCA-associated brain injury.	0.5608
33432632	Artificial organs	2021	Differential expression profiles of circular RNAs in the rat hippocampus after deep hypothermic circulatory arrest.		rno_circRNA_015149	rno_circ_Anks1b	Anks1b	deep hypothermic circulatory arrest-associated brain injury	MONDO:0043510	brain injury	down-regulated	RT-qPCR; Microarray	"rno_circRNA_015149 was significantly down-regulated in rat hippocampus after DHCA and validated by RT-qPCR. The study predicts that it may be involved in DHCA-associated brain injury through circRNA-miRNA-mRNA ceRNA networks and enriched pathways including histidine metabolism, adipocytokine signaling and cAMP signaling."	0.5608
33440987	Neoplasma	2021	CircRNA hsa_circ_0030018 regulates the development of glioma via regulating the miR-1297/RAB21 axis.	hsa_circ_0030018	circ-POSTN / circ_0030018	hsa_circ_POSTN	POSTN	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"hsa_circ_0030018 is up-regulated in glioma tissues and cells. It acts as an oncogenic circRNA by sponging miR-1297 to increase RAB21 expression, thereby promoting proliferation, migration, invasion, metastasis, cell cycle progression, and xenograft tumor growth while suppressing apoptosis. The study suggests hsa_circ_0030018 as a potential diagnostic/prognostic biomarker and therapeutic target for glioma."	0.8279
33447555	Gland surgery	2020	The decreased expression of hsa_circ_0043278 and its relationship with clinicopathological features of breast cancer.	hsa_circ_0043278		hsa_circ_TADA2A	TADA2A	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	"This study identified hsa_circ_0043278 as a significantly down-regulated circRNA in human breast cancer tissues by microarray and validated its decreased expression by qRT-PCR in clinical samples. Its lower expression was associated with lymph node metastasis and histological type, and ROC analysis suggested potential diagnostic value. Bioinformatics prediction suggested that hsa_circ_0043278 may function through putative miRNA sponge interactions, but these interactions were not experimentally validated."	0.5047
33470617	Anti-cancer drugs	2021	Circular RNA hsa_circ_0000554 promotes progression and elevates radioresistance through the miR-485-5p/fermitin family members 1 axis in esophageal cancer.	hsa_circ_0000554	circ_0000554	hsa_circ_LIN52	LIN52	esophageal cancer	MONDO:0007576	esophageal cancer	up-regulated	RT-qPCR	"hsa_circ_0000554/circ_0000554 is upregulated in esophageal cancer tissues, radioresistant esophageal cancer tissues, and esophageal cancer cell lines. It promotes malignant phenotypes and radioresistance by sponging miR-485-5p to regulate FERMT1 expression; knockdown suppresses colony formation, migration and invasion while increasing apoptosis and radiosensitivity."	0.6521
33470895	Cancer biotherapy & radiopharmaceuticals	2023	Circ_0058058 Knockdown Inhibits Acute Myeloid Leukemia Progression by Sponging miR-4319 to Regulate EIF5A2 Expression.	hsa_circ_0058058	circ_0058058			Acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; Microarray	"circ_0058058 is up-regulated in AML patient serum samples and AML cell lines. Functionally, circ_0058058 supports AML progression by promoting proliferation, migration, and invasion while suppressing apoptosis. Mechanistically, it acts as a sponge for miR-4319 to increase EIF5A2 expression, suggesting potential therapeutic relevance."	0.7416
33473055	Endocrine journal	2021	Circular RNA circ_0008274 enhances the malignant progression of papillary thyroid carcinoma via modulating solute carrier family 7 member 11 by sponging miR-154-3p.	hsa_circ_0008274	circ_0008274			papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circ_0008274 is up-regulated in PTC and its high expression predicts poor prognosis. Functionally, circ_0008274 promotes malignant progression by inhibiting apoptosis and enhancing migration, adhesion and in vivo tumor growth. Mechanistically, it sponges miR-154-3p to increase SLC7A11 expression, forming a circ_0008274/miR-154-3p/SLC7A11 regulatory axis."	0.7396
33493415	DNA and cell biology	2021	Identification of Circular RNA hsa_circ_0001599 as a Novel Biomarker for Large-Artery Atherosclerotic Stroke.	hsa_circ_0001599	hsa_circRNA_0001599	hsa_circ_FKBP5	FKBP5	ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0001599 is up-regulated in PBMCs from LAA-stroke patients. Its expression correlates positively with stroke severity and infarct volume and shows diagnostic utility for distinguishing LAA-stroke patients from controls.	0.6556
33493415	DNA and cell biology	2021	Identification of Circular RNA hsa_circ_0001599 as a Novel Biomarker for Large-Artery Atherosclerotic Stroke.	hsa_circ_0001460				ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0001460 was identified by transcriptome-wide circRNA profiling and validated by qRT-PCR as up-regulated in PBMCs from LAA-stroke patients. The study did not further define its mechanism or clinical diagnostic performance.	0.585
33493415	DNA and cell biology	2021	Identification of Circular RNA hsa_circ_0001599 as a Novel Biomarker for Large-Artery Atherosclerotic Stroke.	hsa_circ_0004338				ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0004338 was identified by transcriptome-wide circRNA profiling and validated by qRT-PCR as up-regulated in PBMCs from LAA-stroke patients. The study did not further define its mechanism or clinical diagnostic performance.	0.585
33493415	DNA and cell biology	2021	Identification of Circular RNA hsa_circ_0001599 as a Novel Biomarker for Large-Artery Atherosclerotic Stroke.	hsa_circ_0007637				ischemic stroke / IS	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0007637 was identified by transcriptome-wide circRNA profiling and validated by qRT-PCR as down-regulated in PBMCs from LAA-stroke patients. The study did not further define its mechanism or clinical diagnostic performance.	0.585
33493415	DNA and cell biology	2021	Identification of Circular RNA hsa_circ_0001599 as a Novel Biomarker for Large-Artery Atherosclerotic Stroke.	hsa_circ_0069117				ischemic stroke / IS	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0069117 was identified by transcriptome-wide circRNA profiling and validated by qRT-PCR as down-regulated in PBMCs from LAA-stroke patients. The study did not further define its mechanism or clinical diagnostic performance.	0.585
33493415	DNA and cell biology	2021	Identification of Circular RNA hsa_circ_0001599 as a Novel Biomarker for Large-Artery Atherosclerotic Stroke.	hsa_circ_0073239				ischemic stroke / IS	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0073239 was identified by transcriptome-wide circRNA profiling and validated by qRT-PCR as down-regulated in PBMCs from LAA-stroke patients. The study did not further define its mechanism or clinical diagnostic performance.	0.585
33506896	European review for medical and pharmacological sciences	2021	Circular RNA CircMTO1 suppressed proliferation and metastasis of osteosarcoma through miR-630/KLF6 axis.	hsa_circ_0007142	CircMTO1 / circ_0007142	hsa_circ_MTO1	MTO1	osteosarcoma / OS	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; Microarray	"circMTO1 is down-regulated in osteosarcoma tissues and cell lines, and low expression is associated with poorer overall survival. Functionally, circMTO1 suppresses proliferation, migration, invasion and metastasis-related behavior while promoting apoptosis. Mechanistically, it acts through a ceRNA-like miR-630/KLF6 axis, increasing KLF6 expression by sponging miR-630."	0.7855
33507103	Epigenomics	2021	Identification of circular RNA expression profiles and potential biomarkers for intracerebral hemorrhage.	hsa_circ_0084615				intracerebral hemorrhage / ICH	MONDO:0013792	intracerebral hemorrhage	up-regulated	RNA-seq	"hsa circ 0084615 was identified as one of five circRNAs consistently up-regulated in peripheral blood cells of patients with intracerebral hemorrhage across two cohorts. Its disease association was supported by circRNA sequencing and bioinformatic pathway analysis, without qRT-PCR validation reported for this specific circRNA."	0.5746
33507103	Epigenomics	2021	Identification of circular RNA expression profiles and potential biomarkers for intracerebral hemorrhage.	hsa_circ_0001240	hsa circ 0001240			intracerebral hemorrhage / ICH	MONDO:0013792	intracerebral hemorrhage	up-regulated	RT-qPCR; RNA-seq	"hsa circ 0001240 is an up-regulated peripheral blood circRNA in ICH, validated by qRT-PCR after circRNA sequencing. It was proposed as a promising diagnostic and predictive biomarker and was incorporated into a predicted circRNA-miRNA-mRNA network involving hsa-miR-663b, hsa-miR-1270 and hsa-miR1184."	0.6608
33507103	Epigenomics	2021	Identification of circular RNA expression profiles and potential biomarkers for intracerebral hemorrhage.	hsa_circ_0091669				intracerebral hemorrhage / ICH	MONDO:0013792	intracerebral hemorrhage	up-regulated	RNA-seq	"hsa circ 0091669 was identified as a consistently up-regulated ICH-specific circRNA in human peripheral blood cells. Its association was supported by circRNA sequencing in two cohorts, but no specific qRT-PCR validation or mechanistic interaction was reported for this circRNA."	0.5746
33507103	Epigenomics	2021	Identification of circular RNA expression profiles and potential biomarkers for intracerebral hemorrhage.	hsa_circ_0001947				intracerebral hemorrhage / ICH	MONDO:0013792	intracerebral hemorrhage	up-regulated	RT-qPCR; RNA-seq	"hsa circ 0001947 is an up-regulated peripheral blood circRNA in ICH, validated by qRT-PCR after circRNA sequencing. It was proposed as a promising diagnostic and predictive biomarker and was predicted to target hsa-miR-671-5p, hsa-miR-647 and hsa-miR-892b in a circRNA-miRNA-mRNA network."	0.6608
33507103	Epigenomics	2021	Identification of circular RNA expression profiles and potential biomarkers for intracerebral hemorrhage.		novel circ PLXNC1	hsa_circ_PLXNC1	PLXNC1	intracerebral hemorrhage / ICH	MONDO:0013792	intracerebral hemorrhage	up-regulated	RNA-seq	"novel circ PLXNC1 was identified as an up-regulated novel circRNA in ICH peripheral blood. Its host gene was reported as PLXNC1, but no qRT-PCR validation or circRNA-specific mechanistic assays were reported for this circRNA."	0.5746
33507103	Epigenomics	2021	Identification of circular RNA expression profiles and potential biomarkers for intracerebral hemorrhage.	hsa_circ_0008983				intracerebral hemorrhage / ICH	MONDO:0013792	intracerebral hemorrhage	down-regulated	RNA-seq	"hsa circ 0008983 was identified as a consistently down-regulated ICH-specific circRNA in peripheral blood cells. Evidence for this circRNA was based on circRNA sequencing across the two cohorts, with no specific qRT-PCR validation reported."	0.5746
33507103	Epigenomics	2021	Identification of circular RNA expression profiles and potential biomarkers for intracerebral hemorrhage.	hsa_circ_0001306				intracerebral hemorrhage / ICH	MONDO:0013792	intracerebral hemorrhage	down-regulated	RNA-seq	"hsa circ 0001306 was identified as a consistently down-regulated circRNA in ICH peripheral blood cells. The reported evidence was circRNA sequencing in two clinical cohorts, without qRT-PCR confirmation for this specific circRNA."	0.5746
33507103	Epigenomics	2021	Identification of circular RNA expression profiles and potential biomarkers for intracerebral hemorrhage.	hsa_circ_0001386				intracerebral hemorrhage / ICH	MONDO:0013792	intracerebral hemorrhage	down-regulated	RT-qPCR; RNA-seq	"hsa circ 0001386 is a down-regulated peripheral blood circRNA in ICH, validated by qRT-PCR after circRNA sequencing. It was proposed as a diagnostic biomarker and independent predictor, and was predicted to target five miRNAs within a circRNA-miRNA-mRNA network."	0.6608
33507103	Epigenomics	2021	Identification of circular RNA expression profiles and potential biomarkers for intracerebral hemorrhage.	hsa_circ_0033144				intracerebral hemorrhage / ICH	MONDO:0013792	intracerebral hemorrhage	down-regulated	RNA-seq	"hsa circ 0033144 was identified as one of the consistently down-regulated circRNAs in ICH peripheral blood. The evidence was based on circRNA sequencing and bioinformatic analyses, without specific qRT-PCR validation reported."	0.5746
33507103	Epigenomics	2021	Identification of circular RNA expression profiles and potential biomarkers for intracerebral hemorrhage.	hsa_circ_0005838				intracerebral hemorrhage / ICH	MONDO:0013792	intracerebral hemorrhage	down-regulated	RNA-seq	"hsa circ 0005838 was identified as a consistently down-regulated circRNA in ICH peripheral blood cells. Its disease association was supported by circRNA sequencing in clinical cohorts, but no specific qRT-PCR validation was reported."	0.5746
33507103	Epigenomics	2021	Identification of circular RNA expression profiles and potential biomarkers for intracerebral hemorrhage.	hsa_circ_0005044				intracerebral hemorrhage / ICH	MONDO:0013792	intracerebral hemorrhage	down-regulated	RNA-seq	"hsa circ 0005044 was detected as a consistently down-regulated ICH-specific circRNA in peripheral blood cells. The evidence was limited to circRNA sequencing and bioinformatic analysis, with no qRT-PCR validation reported for this circRNA."	0.5746
33507103	Epigenomics	2021	Identification of circular RNA expression profiles and potential biomarkers for intracerebral hemorrhage.	hsa_circ_0004096				intracerebral hemorrhage / ICH	MONDO:0013792	intracerebral hemorrhage	down-regulated	RNA-seq	hsa circ 0004096 was identified as a consistently down-regulated ICH-specific circRNA in peripheral blood cells. No circRNA-specific mechanistic or qRT-PCR validation results were reported beyond sequencing-based expression profiling.	0.5746
33507103	Epigenomics	2021	Identification of circular RNA expression profiles and potential biomarkers for intracerebral hemorrhage.	hsa_circ_0006491				intracerebral hemorrhage / ICH	MONDO:0013792	intracerebral hemorrhage	down-regulated	RNA-seq	hsa circ 0006491 was identified as a consistently down-regulated circRNA in ICH peripheral blood. The study did not report qRT-PCR validation or specific molecular interactions for this circRNA.	0.5746
33507103	Epigenomics	2021	Identification of circular RNA expression profiles and potential biomarkers for intracerebral hemorrhage.		novel circ ERBB2	hsa_circ_ERBB2	ERBB2	intracerebral hemorrhage / ICH	MONDO:0013792	intracerebral hemorrhage	down-regulated	RNA-seq	"novel circ ERBB2 was identified as a novel down-regulated circRNA in ICH peripheral blood, with ERBB2 reported as its host gene. Its evidence was sequencing-based, and its potential relevance was inferred from host-gene pathway analysis including ERBB receptor signaling."	0.5746
33507103	Epigenomics	2021	Identification of circular RNA expression profiles and potential biomarkers for intracerebral hemorrhage.		novel circ 11364			intracerebral hemorrhage / ICH	MONDO:0013792	intracerebral hemorrhage	down-regulated	RNA-seq	novel circ 11364 was identified as a down-regulated novel circRNA in ICH peripheral blood cells. The article reported no host gene for this circRNA and did not provide circRNA-specific mechanistic or qRT-PCR validation data.	0.5746
33520363	American journal of cancer research	2021	A circGLIS3/miR-644a/PTBP1 positive feedback loop promotes the malignant biological progressions of non-small cell lung cancer.	hsa_circ_0004221	circGLIS3	hsa_circ_GLIS3	GLIS3	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circGLIS3 is an up-regulated circRNA in NSCLC tissues and cell lines and is associated with larger tumor size, lymphatic metastasis, later TNM stage, and shorter overall survival. It promotes NSCLC proliferation, migration, invasion, tumor growth and metastasis while inhibiting apoptosis. Mechanistically, circGLIS3 functions as a miRNA sponge and forms a positive feedback loop with miR-644a and PTBP1, in which circGLIS3 increases PTBP1 expression via miR-644a and PTBP1 enhances circGLIS3 circularization."	0.8684
33520365	American journal of cancer research	2021	CircularRNA circPARP4 promotes glioblastoma progression through sponging miR-125a-5p and regulating FUT4.	hsa_circ_0005198	circPARP4	hsa_circ_PARP4	PARP4	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; Microarray	"circPARP4 is up-regulated in glioma/GBM and positively associated with pathological grade. It promotes glioma progression by enhancing proliferation, colony formation, migration, invasion, EMT and xenograft tumor growth while suppressing apoptosis. Mechanistically, cytoplasmic circPARP4 functions as a miR-125a-5p sponge to regulate FUT4, forming a circPARP4/miR-125a-5p/FUT4 oncogenic axis."	0.786
33534412	Anti-cancer drugs	2021	"Circular RNA circ_0000372 contributes to the proliferation, migration and invasion of colorectal cancer by elevating IL6 expression via sponging miR-495."	hsa_circ_0000372		hsa_circ_APLP2	APLP2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0000372 is an APLP2-derived circRNA that is upregulated in colorectal cancer tissues and cell lines, and high expression predicts poorer overall survival. Functionally, it promotes CRC proliferation, migration, invasion and xenograft tumor growth. Mechanistically, cytoplasmic circ_0000372 sponges miR-495 to increase IL6 expression and enhance JAK2/STAT3 signaling."	0.835
33534519	Spine	2021	Circular RNA Expression Profile in Patients with Lumbar Spinal Stenosis Associated with Hypertrophied Ligamentum Flavum.	hsa_circ_0021604				lumbar spinal stenosis / LSS	MONDO:0044753	lumbar spinal stenosis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0021604 was significantly up-regulated in hypertrophic ligamentum flavum tissues from LSS patients and was confirmed by qRT-PCR after circRNA sequencing. The study suggests it may participate in LF hypertrophy through predicted circRNA-miRNA sponge interactions, but no circRNA-specific functional assay was reported for this circRNA."	0.4685
33534519	Spine	2021	Circular RNA Expression Profile in Patients with Lumbar Spinal Stenosis Associated with Hypertrophied Ligamentum Flavum.	hsa_circ_0025489				lumbar spinal stenosis / LSS	MONDO:0044753	lumbar spinal stenosis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0025489 was significantly up-regulated in hypertrophic ligamentum flavum tissues from LSS patients and was confirmed by qRT-PCR after circRNA sequencing. The study suggests it may participate in LF hypertrophy through predicted circRNA-miRNA sponge interactions, but no circRNA-specific functional assay was reported for this circRNA."	0.4685
33534519	Spine	2021	Circular RNA Expression Profile in Patients with Lumbar Spinal Stenosis Associated with Hypertrophied Ligamentum Flavum.	hsa_circ_0002599				lumbar spinal stenosis / LSS	MONDO:0044753	lumbar spinal stenosis	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0002599 was significantly down-regulated in hypertrophic ligamentum flavum tissues from LSS patients and was confirmed by qRT-PCR after circRNA sequencing. The study suggests it may participate in LF hypertrophy through predicted circRNA-miRNA sponge interactions, but no circRNA-specific functional assay was reported for this circRNA."	0.4685
33534519	Spine	2021	Circular RNA Expression Profile in Patients with Lumbar Spinal Stenosis Associated with Hypertrophied Ligamentum Flavum.	hsa_circ_0052318				lumbar spinal stenosis / LSS	MONDO:0044753	lumbar spinal stenosis	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0052318 was significantly down-regulated in hypertrophic ligamentum flavum tissues from LSS patients and was confirmed by qRT-PCR. Functional overexpression experiments in LFH-derived LF cells showed that hsa_circ_0052318 decreases collagen I and III mRNA/protein expression, supporting an anti-fibrotic role; the study also predicted a hsa_circ_0052318-miRNA-mediated network including miR-199a."	0.6102
33534519	Spine	2021	Circular RNA Expression Profile in Patients with Lumbar Spinal Stenosis Associated with Hypertrophied Ligamentum Flavum.	hsa_circ_0003609				lumbar spinal stenosis / LSS	MONDO:0044753	lumbar spinal stenosis	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0003609 was significantly down-regulated in hypertrophic ligamentum flavum tissues from LSS patients and was confirmed by qRT-PCR. The authors propose that it may participate in LF hypertrophy by targeting miR-155 and may represent a potential therapeutic target for LSS, although no direct functional assay was reported for this circRNA."	0.4685
33547137	Journal of medical genetics	2022	Circular RNA-based biomarkers in blood of patients with Fabry disease and related phenotypes.	hsa_circ_0006853		hsa_circ_RPPH1	RPPH1	Fabry disease / FD	MONDO:0010526	Fabry disease	up-regulated	RT-qPCR	"hsa_circ_0006853 is a blood-based Fabry disease biomarker validated by qPCR. It is elevated in FD, distinguishes FD from healthy and AKI controls, and is associated with Classic phenotype, severe genotype, therapy status, early symptoms and organ involvement."	0.5047
33547137	Journal of medical genetics	2022	Circular RNA-based biomarkers in blood of patients with Fabry disease and related phenotypes.	hsa_circ_0083766		hsa_circ_EPHX2	EPHX2	Fabry disease / FD	MONDO:0010526	Fabry disease	up-regulated	RT-qPCR	"hsa_circ_0083766 is a qPCR-validated circulating biomarker for Fabry disease. It is elevated in FD blood, distinguishes FD from healthy and AKI controls, and correlates with phenotype, treatment status, early symptoms and FD-related organ involvement."	0.5047
33547137	Journal of medical genetics	2022	Circular RNA-based biomarkers in blood of patients with Fabry disease and related phenotypes.	hsa_circ_0002397		hsa_circ_ACTR3	ACTR3	Fabry disease / FD	MONDO:0010526	Fabry disease	up-regulated	RT-qPCR	"hsa_circ_0002397 is a qPCR-validated circulating biomarker for Fabry disease with female-specific elevation. It distinguishes FD from healthy and AKI controls and is associated with age, phenotype, early symptoms and FD-related organ complications."	0.5047
33577032	European review for medical and pharmacological sciences	2021	Circ-0079593 promotes proliferation and migration of melanoma cells by sponging microRNA-433 and elevating EGFR expression.	hsa_circ_0079593	circ-0079593			melanoma	MONDO:0005105	melanoma	up-regulated	RT-qPCR; RNA-seq	"circ-0079593 is up-regulated in melanoma tissues and cell lines, and high expression is associated with poor patient survival. Functionally, circ-0079593 promotes melanoma cell proliferation, migration and invasion. Mechanistically, it acts as a ceRNA for microRNA-433 and elevates EGFR expression, forming a circ-0079593/microRNA-433/EGFR regulatory axis."	0.7078
33595945	Anti-cancer drugs	2021	CircPPP1R12A promotes the progression of colon cancer through regulating CTNNB1 via sponging miR-375.	hsa_circ_0000423	circPPP1R12A / Circ_0000423	hsa_circ_PPP1R12A	PPP1R12A	colon cancer	MONDO:0021063	malignant colon neoplasm	up-regulated	RT-qPCR	"circPPP1R12A is up-regulated in colon cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation, cell cycle progression, migration, invasion and xenograft tumor growth while suppressing apoptosis, mainly through the circPPP1R12A/miR-375/CTNNB1 ceRNA axis."	0.7183
33608702	The Journal of clinical endocrinology and metabolism	2021	Identification of Circulating hsa_circ_0063425 and hsa_circ_0056891 as Novel Biomarkers for Detection of Type 2 Diabetes.	hsa_circ_0063425	circ_0063425			Type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RT-qPCR; Microarray	"hsa_circ_0063425 is downregulated in PBMCs from T2D and IFG subjects and low expression independently predicts T2D, IFG, and insulin resistance. Mechanistically, it may sponge miR-19a-3p to regulate AKT and the insulin PI3K/AKT signaling pathway, supporting its potential as a circulating biomarker for early T2D detection."	0.7397
33608702	The Journal of clinical endocrinology and metabolism	2021	Identification of Circulating hsa_circ_0063425 and hsa_circ_0056891 as Novel Biomarkers for Detection of Type 2 Diabetes.	hsa_circ_0056891				Type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RT-qPCR; Microarray	"hsa_circ_0056891 is downregulated in PBMCs from T2D and IFG subjects and low expression independently predicts T2D, IFG, and insulin resistance. Mechanistically, it may sponge miR-1-3p to regulate PI3K and the insulin PI3K/AKT signaling pathway, supporting its potential as a circulating biomarker for early T2D detection."	0.7397
33616375	Minerva medica	2023	CircTMEM30A/hsa-miR-130a-3p regulates TNFalpha and promotes the malignant progression of COPD with primary lung cancer.		CircTMEM30A	hsa_circ_TMEM30A	TMEM30A	chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR	"CircTMEM30A is highly expressed in COPD with primary lung cancer and its high expression is linked to poor prognosis. Functionally, CircTMEM30A promotes proliferation, migration, invasion and EMT in lung cancer-related cellular models. Mechanistically, it acts through a CircTMEM30A/miR-130a/TNFalpha ceRNA regulatory axis."	0.7032
33629297	European review for medical and pharmacological sciences	2021	Circ_0004417 inhibits the progression of prostate cancer through sponging miR-1228.	hsa_circ_0004417	circ_0004417	hsa_circ_LYPLAL1	LYPLAL1	prostate cancer / PCa	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR	"Circ_0004417 is down-regulated in prostate cancer tissues and cell lines. Its overexpression suppresses prostate cancer cell proliferation, colony formation, and invasion, likely by sponging miR-1228 and regulating the p-Akt/E-cadherin axis. The study suggests circ_0004417 may serve as a potential therapeutic target for prostate cancer."	0.7164
33629298	European review for medical and pharmacological sciences	2021	"Hsa_circ_0041103 induces proliferation, migration and invasion in bladder cancer via the miR-107/FOXK1 axis."	hsa_circ_0041103	Circ0041103			bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"Hsa_circ_0041103/circ0041103 is upregulated in bladder cancer tissues and cell lines and high expression is associated with larger tumor size, advanced stage, lymphatic metastasis, and poor overall survival. Functionally, circ0041103 promotes BCa cell proliferation, migration and invasion. Mechanistically, it acts as a ceRNA by sponging miR-107 to regulate FOXK1 through the circ0041103/miR-107/FOXK1 axis."	0.7078
33653781	Annals of clinical and laboratory science	2021	Upregulation of circ_PVT1 and circ_001569 Indicate Unfavorable Prognosis in Colorectal Cancer.		circ_PVT1	hsa_circ_PVT1	PVT1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_PVT1 was significantly up-regulated in serum/plasma from CRC patients compared with healthy controls. Its higher expression was associated with TNM stage, tumor size, lymph metastasis, diagnostic ROC performance, and unfavorable survival, supporting its role as a potential CRC diagnostic and prognostic biomarker."	0.4992
33653781	Annals of clinical and laboratory science	2021	Upregulation of circ_PVT1 and circ_001569 Indicate Unfavorable Prognosis in Colorectal Cancer.		circ_001569			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_001569 was significantly up-regulated in serum/plasma from CRC patients compared with healthy controls. Its higher expression was associated with TNM stage, tumor size, lymph metastasis, diagnostic ROC performance, and unfavorable survival, supporting its role as a potential CRC diagnostic and prognostic biomarker."	0.4992
33653785	Annals of clinical and laboratory science	2021	Serum hsa_circ_0054633 Is Elevated and Correlated with Clinical Features in Type 2 Diabetes Mellitus.	hsa_circ_0054633	circ_0054633	hsa_circ_PNPT1	polyribonucleotide nucleotidyltransferase 1 (PNPT1)	Type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RT-qPCR	"This clinical case-control study found that serum hsa_circ_0054633 is up-regulated in patients with T2DM. Its elevated serum level may serve as a noninvasive diagnostic biomarker and is associated with glycemic and lipid-related clinical features, including FBG, HbA1c, and LDL."	0.4187
33655888	General physiology and biophysics	2021	circCUX1 promotes neuroblastoma progression and glycolysis by regulating the miR-338-3p/PHF20 axis.	hsa_circ_0132813	circular RNA CUT-like homeobox 1	hsa_circ_CUX1	CUX1	Neuroblastoma / NB	MONDO:0005072	neuroblastoma	up-regulated	RT-qPCR	"circCUX1 is up-regulated in neuroblastoma tissues and cells. It promotes NB cell proliferation, migration, invasion, glycolysis and xenograft tumor growth while suppressing apoptosis, mainly by sponging miR-338-3p to increase PHF20 expression. The study suggests circCUX1 as a potential biomarker or therapeutic marker for NB treatment."	0.7945
33660794	European review for medical and pharmacological sciences	2021	"Circular RNA circSOX4 promotes the proliferation, migration and apoptosis of hepatocellular carcinoma cells by down regulating microRNA-432 expression."		circSOX4	hsa_circ_SOX4	SOX4	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"CircSOX4 is up-regulated in HCC tissues and cell lines, and high circSOX4 expression is associated with poor prognosis. Functionally, circSOX4 promotes HCC cell proliferation, migration and invasion while suppressing apoptosis, likely through binding to and negatively regulating microRNA-432."	0.7113
33660800	European review for medical and pharmacological sciences	2021	"CircPRKCI regulates proliferation, migration and cycle of lung adenocarcinoma cells by targeting miR-219a-5p-regulated CAMK1D."		circRNA protein kinase C iota / CircPRKCI	hsa_circ_PRKCI	PRKCI	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"CircPRKCI is up-regulated in LUAD tissues and cell lines and its high expression is associated with unfavorable prognosis. Functionally, circPRKCI promotes LUAD cell proliferation, migration, and cell cycle progression, at least partly through binding miR-219a-5p and regulating CAMK1D."	0.7113
33661058	Cancer biotherapy & radiopharmaceuticals	2023	"Serum Exosomes-Based Biomarker circ_0008928 Regulates Cisplatin Sensitivity, Tumor Progression, and Glycolysis Metabolism by miR-488/HK2 Axis in Cisplatin-Resistant Nonsmall Cell Lung Carcinoma."	hsa_circ_0008928	circular_0008928 / circSATB2	hsa_circ_SATB2	SATB2	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"Circ_0008928 is upregulated in NSCLC cells, CDDP-resistant NSCLC cells, and serum exosomes from CDDP-resistant NSCLC patients. It promotes cisplatin resistance, proliferation, migration, invasion, and glycolysis by sponging miR-488 and increasing HK2 expression, while knockdown restores CDDP sensitivity and suppresses malignant phenotypes. Serum exosomal circ_0008928 is proposed as a potential diagnostic biomarker for NSCLC."	0.7283
33663188	Zhonghua yi xue za zhi	2021	[Differential circRNA expression profiles in peripheral blood mononuclear cells among mild and severe influenza-associated pneumonia patients].	hsa_circ_0091073				influenza pneumonia	MONDO:0005249	pneumonia	up-regulated	Microarray	"hsa_circ_0091073 was identified by microarray as the most significantly up-regulated circRNA in PBMCs of mild versus severe influenza pneumonia patients. The study predicted influenza pathogenesis-related downstream miRNAs and pathway involvement, but did not experimentally validate a specific mechanistic axis for this circRNA."	0.348
33663188	Zhonghua yi xue za zhi	2021	[Differential circRNA expression profiles in peripheral blood mononuclear cells among mild and severe influenza-associated pneumonia patients].	hsa_circ_0092219				influenza pneumonia	MONDO:0005249	pneumonia	down-regulated	Microarray	"hsa_circ_0092219 was identified by microarray as the most significantly down-regulated circRNA in PBMCs of mild versus severe influenza pneumonia patients. The study predicted downstream miRNA and pathway relationships, but did not experimentally validate a specific mechanistic axis for this circRNA."	0.348
33663188	Zhonghua yi xue za zhi	2021	[Differential circRNA expression profiles in peripheral blood mononuclear cells among mild and severe influenza-associated pneumonia patients].	hsa_circ_0032969				influenza pneumonia	MONDO:0005249	pneumonia	dysregulated	Microarray	hsa_circ_0032969 was included among differentially expressed circRNAs whose predicted downstream miRNAs were related to influenza pathogenic mechanisms. Its expression direction and individual miRNA targets were not separately resolved in the provided text.	0.348
33663188	Zhonghua yi xue za zhi	2021	[Differential circRNA expression profiles in peripheral blood mononuclear cells among mild and severe influenza-associated pneumonia patients].	hsa_circ_0025453				influenza pneumonia	MONDO:0005249	pneumonia	dysregulated	Microarray	hsa_circ_0025453 was included among differentially expressed circRNAs whose predicted downstream miRNAs were related to influenza pathogenic mechanisms. Its expression direction and individual miRNA targets were not separately resolved in the provided text.	0.348
33663188	Zhonghua yi xue za zhi	2021	[Differential circRNA expression profiles in peripheral blood mononuclear cells among mild and severe influenza-associated pneumonia patients].	hsa_circ_0069905				influenza pneumonia	MONDO:0005249	pneumonia	dysregulated	Microarray	hsa_circ_0069905 was included among differentially expressed circRNAs whose predicted downstream miRNAs were related to influenza pathogenic mechanisms. Its expression direction and individual miRNA targets were not separately resolved in the provided text.	0.348
33666515	Biomarkers in medicine	2021	The diagnostic value of plasma exosomal hsa_circ_0070396 for hepatocellular carcinoma.	hsa_circ_0070396	circ 0070396	hsa_circ_NUDT9	NUDT9	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"This study identified plasma exosomal hsa_circ_0070396/circ 0070396 as significantly elevated in HCC and validated its circular form and expression by qRT-PCR, RNase R treatment and Sanger sequencing. Exosomal circ 0070396 showed diagnostic value for distinguishing HCC from healthy donors and non-HCC liver disease controls, and its combination with AFP improved diagnostic performance. Higher exosomal circ 0070396 expression was associated with HCC progression-related features including tumor size, BCLC stages and encapsulation invasion."	0.6238
33675609	Anti-cancer drugs	2021	Circular RNA circ_0021093 regulates miR-432/Annexin A2 pathway to promote hepatocellular carcinoma progression.	hsa_circ_0021093	circ_0021093			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0021093 is up-regulated in HCC tissues and cell lines and high expression is associated with poorer overall survival. Functionally, it promotes HCC proliferation, migration, invasion, EMT and xenograft tumor growth by sponging miR-432 and increasing ANXA2 expression."	0.7126
33683141	Epigenomics	2021	CircRNA profiling identifies circRNF180 as a tumor suppressor in hepatocellular carcinoma.		circGNAO1	hsa_circ_GNAO1	GNAO1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"circGNAO1 was significantly downregulated in HCC tissues and showed strong diagnostic performance for distinguishing HCC from adjacent normal tissues. Bioinformatics analysis predicted hsa-miR-182-5p as its most likely target miRNA, suggesting a possible ceRNA-related role."	0.6841
33683141	Epigenomics	2021	CircRNA profiling identifies circRNF180 as a tumor suppressor in hepatocellular carcinoma.		circRNF180	hsa_circ_RNF180	RNF180	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"circRNF180 was significantly downregulated in HCC and was the main functional circRNA investigated in this study. Its overexpression suppressed HCC cell proliferation, colony formation, migration and invasion, and low expression was associated with microvascular invasion, supporting a tumor-suppressive and biomarker role."	0.7907
33683141	Epigenomics	2021	CircRNA profiling identifies circRNF180 as a tumor suppressor in hepatocellular carcinoma.		circMERTK	hsa_circ_MERTK	MERTK	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	circMERTK was significantly downregulated in HCC tissues and showed diagnostic value for distinguishing HCC from adjacent normal tissues. The study did not report circMERTK-specific functional experiments or validated molecular mechanisms.	0.6841
33683141	Epigenomics	2021	CircRNA profiling identifies circRNF180 as a tumor suppressor in hepatocellular carcinoma.		circSNX6	hsa_circ_SNX6	SNX6	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"circSNX6 was significantly upregulated in HCC tissues after RNA-seq screening and qRT-PCR validation. However, the study did not identify diagnostic utility, clinicopathological association, functional effects, or a validated molecular mechanism for circSNX6."	0.6841
33683343	Blood advances	2021	Deregulated expression of circular RNAs in acute myeloid leukemia.		circBCL11B	hsa_circ_BCL11B	BCL11B	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; RNA-seq	"circBCL11B is a BCL11B exon 2-derived circular RNA that was detected exclusively in AML samples and not in healthy HSPCs. Its high expression was associated with a T-cell-like gene expression signature, and shRNA-mediated knockdown impaired AML cell proliferation and increased cell death/apoptosis under serum-deprivation stress. The study supports circBCL11B as a functionally relevant AML-associated circRNA candidate, although its detailed molecular mechanism remains unresolved."	0.6369
33687273	DNA and cell biology	2021	UVB-Induced ciRS-7 Activates Melanogenesis by Paracrine Effects.		CDR1as / ciRS-7	hsa_circ_CDR1		pigmented skin diseases	MONDO:0000001	disease	up-regulated	RT-qPCR	"This study shows that UVB irradiation upregulates ciRS-7 in human keratinocytes and fibroblasts. ciRS-7 promotes melanogenesis through paracrine effects by sponging miR-7, activating STAT3 and AKT signaling, and increasing FGF2 expression and secretion. The authors propose ciRS-7 as a potential regulator and therapeutic or diagnostic target in pigmented skin diseases."	0.3957
33708563	Gland surgery	2021	Downregulation of hsa_circ_0006220 and its correlation with clinicopathological factors in human breast cancer.	hsa_circ_0006220		hsa_circ_TADA2A	TADA2A	breast cancer	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	hsa_circ_0006220 is significantly downregulated in human breast cancer tissues and its lower expression is associated with histological type and lymph node metastasis. The study suggests that hsa_circ_0006220 may act through regulation of miR-197-5p and may serve as a potential biomarker for breast cancer screening.	0.5849
33716239	Endocrine journal	2021	Silencing circRNA protein kinase C iota (circ-PRKCI) suppresses cell progression and glycolysis of human papillary thyroid cancer through circ-PRKCI/miR-335/E2F3 ceRNA axis.	hsa_circ_0122683	circ-PRKCI / circRNA PRKCI	hsa_circ_PRKCI	PRKCI	papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"circ-PRKCI (hsa_circ_0122683) is upregulated in human PTC tumors and cell lines and is associated with lymph node metastasis and recurrence. Functionally, it promotes PTC cell proliferation, cell cycle progression, migration, invasion, glycolysis, and xenograft tumor growth. Mechanistically, circ-PRKCI functions as a cytoplasmic ceRNA that sponges miR-335 to increase E2F3 expression."	0.8124
33722958	Molecular and cellular biology	2021	Exosome-Mediated Transfer of circ_0000338 Enhances 5-Fluorouracil Resistance in Colorectal Cancer through Regulating MicroRNA 217 (miR-217) and miR-485-3p.	hsa_circ_0000338	circ_0000338	hsa_circ_FCHSD2	FCHSD2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0000338 is up-regulated in 5-FU-resistant colorectal cancer tissues, cells, and serum exosomes. It promotes 5-FU resistance by suppressing miR-217 and miR-485-3p, increasing proliferation and reducing apoptosis under 5-FU treatment. Exosome-mediated transfer of circ_0000338 spreads chemoresistance to sensitive CRC cells and shows diagnostic potential for identifying 5-FU-resistant CRC patients."	0.8568
33733860	DNA and cell biology	2021	circCCND1 Regulates Oxidative Stress and FGF9 to Enhance Chemoresistance of Non-Small Cell Lung Cancer via Sponging miR-187-3p.		circCCND1	hsa_circ_CCND1	CCND1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circCCND1 is up-regulated in NSCLC cells and lung tumor datasets and is associated with advanced stage and poorer survival. Functionally, circCCND1 promotes cisplatin chemoresistance by sustaining NSCLC cell viability/proliferation and inhibiting apoptosis. Mechanistically, it acts through a miR-187-3p/ROS/FGF9 axis."	0.6415
33735118	Anti-cancer drugs	2021	Overexpression of circ_CELSR1 facilitates paclitaxel resistance of ovarian cancer by regulating miR-149-5p/SIK2 axis.		circ_CELSR1	hsa_circ_CELSR1	CELSR1	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circ_CELSR1 is up-regulated in paclitaxel-resistant ovarian cancer tissues and cells. It promotes paclitaxel resistance and malignant cellular behaviors by sponging miR-149-5p to increase SIK2 expression, while its knockdown enhances paclitaxel sensitivity and apoptosis in vitro and in vivo."	0.705
33737493	Journal of biosciences	2021	Circ-HIPK3 regulates YAP1 expression by sponging miR-381-3p to promote oral squamous cell carcinoma development.		Circ-HIPK3	hsa_circ_HIPK3	homeodomain interacting protein kinase 3	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circ-HIPK3 is up-regulated in OSCC tissues and cell lines. It promotes OSCC proliferation, migration, invasion and in vivo tumor growth while suppressing apoptosis, mainly through a ceRNA mechanism in which circ-HIPK3 sponges miR-381-3p to increase YAP1 expression. The study suggests circ-HIPK3 as a potential therapeutic target for OSCC."	0.7177
33737494	Journal of biosciences	2021	Circ_0002711 knockdown suppresses cell growth and aerobic glycolysis by modulating miR-1244/ROCK1 axis in ovarian cancer.	hsa_circ_0002711	circ_0002711			ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"Circ_0002711 is upregulated in ovarian cancer tissues and cell lines. Functional experiments show that circ_0002711 promotes OC cell proliferation, colony formation, aerobic glycolysis/Warburg effect, and xenograft tumor growth. Mechanistically, circ_0002711 regulates the miR-1244/ROCK1 axis and may represent a therapeutic target for OC."	0.7289
33764794	Cancer biotherapy & radiopharmaceuticals	2023	Circ_0016347 Promotes Osteosarcoma Progression by Regulating miR-1225-3p/KCNH1 Axis.	hsa_circ_0016347	circ_0016347	hsa_circ_KCNH1	KCNH1	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ_0016347 is up-regulated in osteosarcoma tissues and cell lines and acts as an oncogenic circRNA. It promotes proliferation, migration, invasion, glycolysis, and xenograft tumor growth by sponging miR-1225-3p and increasing KCNH1 expression, suggesting potential therapeutic relevance in OS."	0.8001
33768996	Journal of biological regulators and homeostatic agents	2021	New biomarker for lung cancer - focus on circSETD3.	hsa_circ_0000567	circSETD3	hsa_circ_SETD3	SETD3	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000567/circSETD3 is up-regulated in gefitinib-resistant NSCLC cell lines. It promotes proliferation, inhibits apoptosis, and contributes to gefitinib resistance through a circSETD3-miR-520h-ABCG2 ceRNA axis, suggesting biomarker potential for lung cancer drug resistance."	0.6731
33768996	Journal of biological regulators and homeostatic agents	2021	New biomarker for lung cancer - focus on circSETD3.	hsa_circ_0006867				lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0006867 was identified as one of five common differentially expressed circRNAs in gefitinib-resistant NSCLC cell models and was up-regulated in H292R and PC9R cells. No functional mechanism was reported for this circRNA.	0.1904
33768996	Journal of biological regulators and homeostatic agents	2021	New biomarker for lung cancer - focus on circSETD3.	hsa_circ_0001147				lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0001147 was identified as one of five common differentially expressed circRNAs in gefitinib-resistant NSCLC cell models and was down-regulated in H292R and PC9R cells. No functional mechanism was reported for this circRNA.	0.1904
33768996	Journal of biological regulators and homeostatic agents	2021	New biomarker for lung cancer - focus on circSETD3.	hsa_circ_0000655				lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0000655 was identified as one of five common differentially expressed circRNAs in gefitinib-resistant NSCLC cell models and was up-regulated in H292R and PC9R cells. No functional mechanism was reported for this circRNA.	0.1904
33768996	Journal of biological regulators and homeostatic agents	2021	New biomarker for lung cancer - focus on circSETD3.	hsa_circ_0000620				lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0000620 was identified as one of five common differentially expressed circRNAs in gefitinib-resistant NSCLC cell models and was up-regulated in H292R and PC9R cells. No functional mechanism was reported for this circRNA.	0.1904
33771844	The Journal of pharmacology and experimental therapeutics	2021	circ-Keratin 6c Promotes Malignant Progression and Immune Evasion of Colorectal Cancer through microRNA-485-3p/Programmed Cell Death Receptor Ligand 1 Axis.	hsa_circ_0026416	circ-KRT6C / circ-keratin 6c	hsa_circ_KRT6C	KRT6C	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ-KRT6C is an up-regulated oncogenic circRNA in colorectal cancer tissues and cells, and high expression is associated with poorer overall survival. Mechanistically, circ-KRT6C sponges miR-485-3p to increase PDL1 expression, promoting proliferation, migration, invasion, immune evasion and xenograft tumor growth while suppressing apoptosis."	0.786
33781094	Cancer biotherapy & radiopharmaceuticals	2022	circKLHL24 Blocks Breast Cancer Development by Regulating the miR-1204/ALX4 Network.	hsa_circ_0001368	circKLHL24 / circ_0001368	hsa_circ_KLHL24	KLHL24	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR	"circKLHL24 is downregulated in breast cancer tissues and cell lines. Its overexpression inhibits breast cancer cell viability, proliferation, migration, invasion, glycolysis, and xenograft tumor growth. Mechanistically, circKLHL24 sponges miR-1204 to increase ALX4 expression, forming a circKLHL24/miR-1204/ALX4 tumor-suppressive regulatory network."	0.8119
33792237	Minerva endocrinology	2024	Identification of a potentially functional circRNA-miRNA-mRNA regulatory network in type 2 diabetes mellitus by integrated microarray analysis.	hsa_circ_0000907	circMYO9B	hsa_circ_MYO9B	MYO9B	Type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	dysregulated	Microarray	"hsa_circ_0000907/circMYO9B was identified by integrated GEO microarray analysis as one of four key circRNAs in a predicted T2DM-associated circRNA-miRNA-mRNA and circRNA-miRNA-hub gene regulatory network. The study suggests it may be involved in T2DM occurrence and development, but experimental validation beyond bioinformatics analysis was not performed."	0.1768
33792237	Minerva endocrinology	2024	Identification of a potentially functional circRNA-miRNA-mRNA regulatory network in type 2 diabetes mellitus by integrated microarray analysis.	hsa_circ_0024731	circGRAMD1B	hsa_circ_GRAMD1B	GRAMD1B	Type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	dysregulated	Microarray	hsa_circ_0024731/circGRAMD1B was identified as one of four key circRNAs in the T2DM-associated regulatory subnetwork and hub-gene network. Its proposed role is based on microarray-derived differential expression and bioinformatics prediction of a circRNA-miRNA-mRNA regulatory mechanism.	0.1768
33792237	Minerva endocrinology	2024	Identification of a potentially functional circRNA-miRNA-mRNA regulatory network in type 2 diabetes mellitus by integrated microarray analysis.	hsa_circ_0059104	circTHAP4	hsa_circ_THAP4	THAP4	Type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	dysregulated	Microarray	"hsa_circ_0059104/circTHAP4 was selected as a key circRNA in the T2DM-associated circRNA-miRNA-mRNA subnetwork. The authors propose that it may contribute to T2DM and its complications through predicted sponge/regulatory network effects, but note that future experimental validation is required."	0.1768
33792237	Minerva endocrinology	2024	Identification of a potentially functional circRNA-miRNA-mRNA regulatory network in type 2 diabetes mellitus by integrated microarray analysis.	hsa_circ_0038314	circTMC7	hsa_circ_TMC7	TMC7	Type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	dysregulated	Microarray	hsa_circ_0038314/circTMC7 was one of the four highest-ranking circRNAs identified in the integrated T2DM regulatory network analysis. The paper proposes it as a potential contributor to T2DM pathogenesis and a possible therapeutic-target lead through predicted circRNA-miRNA-mRNA regulation.	0.1768
33818550	Journal of cardiovascular pharmacology	2021	"Circ_GRN Promotes the Proliferation, Migration, and Inflammation of Vascular Smooth Muscle Cells in Atherosclerosis Through miR-214-3p/FOXO1 Axis."	hsa_circ_0044073		hsa_circ_GRN	GRN	atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"circ_GRN is up-regulated in serum from patients with atherosclerosis and in ox-LDL-induced HVSMCs. It promotes HVSMC proliferation, migration, and inflammatory cytokine production by acting as a sponge for miR-214-3p and thereby regulating FOXO1 expression, suggesting a potential role in AS progression and intervention."	0.7595
33841644	American journal of translational research	2021	Tumor-derived exosomal circRNA051239 promotes proliferation and migration of epithelial ovarian cancer.		circRNA051239			epithelial ovarian cancer / EOC	MONDO:0005140	ovarian carcinoma	up-regulated	RT-qPCR; Microarray	"circRNA051239 is up-regulated in epithelial ovarian cancer tissues and plasma exosomes. Tumor-derived exosomal circRNA051239 promotes proliferation, migration, invasion and metastatic behavior of recipient ovarian cancer cells by acting as a ceRNA for miR-509-5p and increasing PRSS3 expression, and it may have diagnostic biomarker potential."	0.7028
33841659	American journal of translational research	2021	CircATP5SL promotes infantile haemangiomas progression via IGF1R regulation by targeting miR-873-5p.		circATP5SL	hsa_circ_ATP5SL	ATP5SL	haemangioma	MONDO:0006500	hemangioma	up-regulated	RT-qPCR; Microarray	"circATP5SL is up-regulated in infantile haemangioma tissues and mainly localizes in the cytoplasm. It promotes haemangioma cell proliferation, invasion, migration, and in vivo xenograft growth while suppressing apoptosis. Mechanistically, circATP5SL sponges miR-873-5p to relieve miR-873-5p-mediated inhibition of IGF1R, suggesting therapeutic relevance in IH."	0.7893
33853086	Anti-cancer drugs	2021	Exosomal circ_0004136 enhances the progression of pediatric acute myeloid leukemia depending on the regulation of miR-570-3p/TSPAN3 axis.	hsa_circ_0004136	circ_0004136	hsa_circ_KCNQ5	KCNQ5	pediatric acute myeloid leukemia / pediatric AML	MONDO:0004996	childhood acute myeloid leukemia	up-regulated	RT-qPCR	"This study found that exosomal circ_0004136 is up-regulated in pediatric AML serum and AML cell lines. Circ_0004136 promotes AML malignant phenotypes by sponging miR-570-3p and modulating TSPAN3 expression, while exosome-mediated circ_0004136 knockdown suppresses viability, cell cycle progression, migration and invasion and promotes apoptosis. The findings suggest an exosome-related circ_0004136/miR-570-3p/TSPAN3 regulatory mechanism with potential therapeutic relevance in AML."	0.8119
33880997	General physiology and biophysics	2021	circ_LRIG3 contributes to the progression of hepatocellular carcinoma by elevating RNF38 via sponging miR-449a.	hsa_circ_0027345	circ_LRIG3 / circ_0027345	hsa_circ_LRIG3	LRIG3	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_LRIG3 is up-regulated in HCC tissues and cell lines and functions as a tumor promoter. Its knockdown inhibits proliferation, migration, invasion, EMT-related marker changes, Smad2/3 pathway activation, and xenograft tumor growth while promoting apoptosis. Mechanistically, circ_LRIG3 sponges miR-449a to increase RNF38 expression and activate the miR-449a/RNF38/Smad2/3 axis."	0.7595
33894314	Cellular signalling	2021	Circular RNA circE2F2 promotes malignant progression of ovarian cancer cells by upregulating the expression of E2F2 protein via binding to HuR protein.	hsa_circ_0000030	circE2F2	hsa_circ_E2F2	E2F2	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circE2F2 is a human E2F2-derived circRNA that is upregulated in ovarian cancer tissues and cell lines, and high expression predicts poor survival. Functionally, circE2F2 promotes ovarian cancer proliferation, migration, invasion, tumor growth, metastasis, and glucose metabolism by binding HuR and stabilizing E2F2 mRNA, leading to increased E2F2 expression."	0.8439
33902207	Zhonghua zhong liu za zhi [Chinese journal of oncology]	2021	[Effects of silencing circRNA ABCB10 expression on biological properties of colorectal cancer cells].		circRNA ABCB10	hsa_circ_ABCB10		colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"In this study, circABCB10 was up-regulated in colorectal cancer tissues and cell lines. Silencing circABCB10 inhibited SW480 cell proliferation, migration, invasion and xenograft growth, promoted apoptosis, and increased radiosensitivity. Mechanistically, circABCB10 acted through miR-217 regulation, suggesting its potential as a therapeutic and radiosensitizing target in colorectal cancer."	0.6536
33902208	Zhonghua zhong liu za zhi [Chinese journal of oncology]	2021	"[Hsa_circ_0006948 regulates the proliferation, migration and invasion in osteosarcoma by regulation of the expression of miR-490-3p target ATG7]."	hsa_circ_0006948	circ_0006948			osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0006948 is up-regulated in osteosarcoma tissues and Saos-2 cells. It promotes osteosarcoma cell proliferation, migration and invasion by targeting miR-490-3p and regulating ATG7 expression, and its expression increases with higher clinicopathological stage."	0.6829
33929989	Anti-cancer drugs	2021	Silencing of circ_0078607 prevents development of gastric cancer and inactivates the ERK1/2/AKT pathway through the miR-188-3p/RAP1B axis.	hsa_circ_0078607	circ_0078607			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_0078607 is up-regulated in gastric cancer tissues, patient plasma and gastric cancer cell lines. It functions as a tumor-promoting circRNA by regulating the miR-188-3p/RAP1B axis and ERK1/2/AKT signaling, thereby promoting proliferation and tumor growth while suppressing apoptosis."	0.7289
33929991	Anti-cancer drugs	2021	CircRASSF2 facilitates the proliferation and metastasis of colorectal cancer by mediating the activity of Wnt/beta-catenin signaling pathway by regulating the miR-195-5p/FZD4 axis.	hsa_circ_0059354	circRASSF2	hsa_circ_RASSF2	RASSF2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"CircRASSF2 is upregulated in colorectal cancer tissues and cell lines, and high expression is associated with poor overall survival and diagnostic potential. Functionally, circRASSF2 promotes CRC proliferation, migration, invasion, metastasis and xenograft tumor growth while suppressing apoptosis. Mechanistically, it sponges miR-195-5p to regulate FZD4 and activate the Wnt/beta-catenin pathway."	0.8066
33929992	Anti-cancer drugs	2021	"Hsa_circ_0069094 knockdown inhibits cell proliferation, migration, invasion and glycolysis, while induces cell apoptosis by miR-661/HMGA1 axis in breast cancer."	hsa_circ_0069094	circ_0069094			breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"Hsa_circ_0069094 is up-regulated in breast cancer tissues and cells and high expression is associated with poor survival and lymph node metastasis. Functional experiments show that hsa_circ_0069094 promotes proliferation, migration, invasion, glycolysis and tumor growth while suppressing apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-661 to regulate HMGA1."	0.8202
33951696	Journal of cardiovascular pharmacology	2021	Circular RNA circ_0010729 Knockdown Attenuates Oxygen-Glucose Deprivation-Induced Human Cardiac Myocytes Injury by miR-338-3p/CALM2 Axis.	hsa_circ_0010729	circ_0010729	hsa_circ_HSPG2	HSPG2	cardiovascular disease	MONDO:0004995	cardiovascular disorder	up-regulated	RT-qPCR	"hsa_circ_0010729 is up-regulated in OGD-treated cardiac myocytes. Its knockdown protects against OGD-induced injury by restoring cell viability and suppressing apoptosis and autophagy. Mechanistically, circ_0010729 sponges miR-338-3p and regulates CALM2 expression through a ceRNA axis, suggesting a potential therapeutic target for cardiovascular disease-related cardiac myocyte injury."	0.6376
33955785	Epigenomics	2021	Identification of an immune signature to predict poor clinical outcome in cervical cancer.	hsa_circ_0025721				cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RNA-seq	hsa circ 0025721 was identified as an up-regulated cervical cancer circRNA in a bioinformatics-derived circRNA-miRNA-CXCL8 network. The study suggests that it may act through a ceRNA mechanism to increase CXCL8 expression and is associated with immune infiltration features.	0.3991
33955785	Epigenomics	2021	Identification of an immune signature to predict poor clinical outcome in cervical cancer.	hsa_circ_0060927		hsa_circ_CYP24A1	CYP24A1	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RNA-seq	"hsa circ 0060927 was identified as an up-regulated cervical cancer circRNA in the predicted circRNA-miRNA-CXCL8 network. It may contribute to CXCL8 upregulation through miRNA sponging and showed correlations with monocytes, macrophage M0 and macrophage M2 infiltration; it was also correlated with its host gene CYP24A1."	0.3991
33955785	Epigenomics	2021	Identification of an immune signature to predict poor clinical outcome in cervical cancer.	hsa_circ_0005403				cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RNA-seq	"hsa circ 0005403 was identified as an up-regulated cervical cancer circRNA in the predicted circRNA-miRNA-CXCL8 network. The study suggests that it may regulate CXCL8 through miRNA sponging and that it is associated with monocytes, activated mast cells and follicular helper T cells."	0.3991
33955785	Epigenomics	2021	Identification of an immune signature to predict poor clinical outcome in cervical cancer.	hsa_circ_0001307				cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RNA-seq	"hsa circ 0001307 was identified as an up-regulated cervical cancer circRNA in the predicted circRNA-miRNA-CXCL8 network. The study suggests that it may regulate CXCL8 through miRNA sponging and that it is associated with monocytes, activated mast cells and activated memory CD4 T cells."	0.3991
33980772	Endocrine journal	2021	"Circular RNA circ_0000712 regulates high glucose-induced apoptosis, inflammation, oxidative stress, and fibrosis in (DN) by targeting the miR-879-5p/SOX6 axis."	mmu_circ_0000712	circ_0000712			Diabetic nephropathy / DN	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"In this mouse DN study, circ_0000712 was up-regulated in db/db DN mice and high glucose-treated SV40-MES13 mesangial cells. Functional experiments showed that circ_0000712 knockdown reduced high glucose-induced apoptosis, inflammation, oxidative stress, and fibrosis. Mechanistically, circ_0000712 acted as a ceRNA for miR-879-5p to increase SOX6 expression, forming the circ_0000712/miR-879-5p/SOX6 axis."	0.6959
33994521	Neuroreport	2021	Knockdown circular RNA circGFRA1 inhibits glioma cell proliferation and migration by upregulating microRNA-99a.		circGFRA1	hsa_circ_GFRA1	GFRA1	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circGFRA1 is upregulated in human glioma tissues. In U251 glioma cells, circGFRA1 knockdown suppresses viability, proliferation, colony formation and migration while promoting apoptosis. Mechanistically, circGFRA1 functions as a miR-99a sponge and modulates AKT/FOXO1 and mTOR pathway activity."	0.705
34001703	Anti-cancer drugs	2021	Curcumin suppresses renal carcinoma tumorigenesis by regulating circ-FNDC3B/miR-138-5p/IGF2 axis.	hsa_circ_0067972	circular RNA fibronectin type III domain-containing protein 3B / circ-FNDC3B	hsa_circ_FNDC3B	FNDC3B	renal carcinoma	MONDO:0005206	renal carcinoma	up-regulated	RT-qPCR	"circ-FNDC3B is up-regulated in renal carcinoma tissues and cell lines and promotes tumorigenic phenotypes. Mechanistically, it sponges miR-138-5p to enhance IGF2 expression, thereby supporting proliferation and suppressing apoptosis. Curcumin down-regulates circ-FNDC3B, and circ-FNDC3B overexpression weakens curcumin-induced inhibition of renal carcinoma growth in vitro and in xenografts."	0.7177
34009009	Cancer biotherapy & radiopharmaceuticals	2022	Epidermal Growth Factor Receptor Mutation Mechanisms in Nonsmall Cell Lung Cancer by Transcriptome Sequencing.		circ_000373			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	dysregulated	RNA-seq	"circ_000373 was identified as a differentially expressed circRNA involved in ceRNA networks associated with EGFR mutation mechanisms in NSCLC. The paper proposes circ_000373-related axes with miR-520a-5p/ABCA3, miR-1293/VAMP1, and miR-378a-5p/APLN, and suggests that key RNAs in this network may predict EGFR mutations."	0.1768
34009009	Cancer biotherapy & radiopharmaceuticals	2022	Epidermal Growth Factor Receptor Mutation Mechanisms in Nonsmall Cell Lung Cancer by Transcriptome Sequencing.		circ_004103			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	dysregulated	RNA-seq	"circ_004103 was identified among circRNAs implicated by KEGG pathway enrichment in EGFR mutation-related NSCLC analysis. Its predicted associations were Ras signaling and PI3K-Akt signaling, but no experimental validation or specific expression direction was reported."	0.1768
34009009	Cancer biotherapy & radiopharmaceuticals	2022	Epidermal Growth Factor Receptor Mutation Mechanisms in Nonsmall Cell Lung Cancer by Transcriptome Sequencing.		circ_012076			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	dysregulated	RNA-seq	"circ_012076 was identified among circRNAs implicated by KEGG pathway enrichment in EGFR mutation-related NSCLC analysis. It was associated with the human papillomavirus infection pathway, but no specific miRNA axis, expression direction, or experimental validation was reported."	0.1768
34009009	Cancer biotherapy & radiopharmaceuticals	2022	Epidermal Growth Factor Receptor Mutation Mechanisms in Nonsmall Cell Lung Cancer by Transcriptome Sequencing.		circ_013487			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	dysregulated	RNA-seq	"circ_013487 was identified among circRNAs implicated by KEGG pathway enrichment in EGFR mutation-related NSCLC analysis. It was associated with the human papillomavirus infection pathway, but no specific miRNA axis, expression direction, or experimental validation was reported."	0.1768
34009856	Journal of cardiovascular pharmacology	2021	CircJARID2 Regulates Hypoxia-Induced Injury in H9c2 Cells by Affecting miR-9-5p-Mediated BNIP3.		circJARID2	rno_circ_JARID2		myocardial infarction / MI	MONDO:0005068	myocardial infarction	up-regulated	RT-qPCR	"This study found that circJARID2 is up-regulated under hypoxia in H9c2 cardiomyocytes and in cardiac tissues of MI mice. circJARID2 aggravates hypoxia-induced injury by sponging miR-9-5p and increasing BNIP3 expression, thereby promoting apoptosis and inflammatory damage while reducing cell viability. The authors suggest circJARID2 may be a molecular target for MI."	0.7221
34009856	Journal of cardiovascular pharmacology	2021	CircJARID2 Regulates Hypoxia-Induced Injury in H9c2 Cells by Affecting miR-9-5p-Mediated BNIP3.		circJARID2	mmu_circ_JARID2		myocardial infarction / MI	MONDO:0005068	myocardial infarction	up-regulated	RT-qPCR	"This study found that circJARID2 is up-regulated under hypoxia in H9c2 cardiomyocytes and in cardiac tissues of MI mice. circJARID2 aggravates hypoxia-induced injury by sponging miR-9-5p and increasing BNIP3 expression, thereby promoting apoptosis and inflammatory damage while reducing cell viability. The authors suggest circJARID2 may be a molecular target for MI."	0.7221
34016832	Anti-cancer drugs	2021	Circular RNA circ_ASAP2 regulates drug sensitivity and functional behaviors of cisplatin-resistant gastric cancer cells by the miR-330-3p/NT5E axis.	hsa_circ_0006089	circ_ASAP2 / circ_0006089	hsa_circ_ASAP2	ASAP2	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_ASAP2 is up-regulated in cisplatin-resistant gastric cancer tissues and cells. It promotes DDP resistance and malignant behaviors by binding miR-330-3p and increasing NT5E expression, while circ_ASAP2 knockdown enhances drug sensitivity, induces apoptosis, suppresses proliferation, migration and invasion, and reduces xenograft tumor growth."	0.7183
34017382	American journal of translational research	2021	Circular RNA PCDH10 regulates the tumorigenesis of pancreatic cancer through the miR-338-3p/hTERT axis.	hsa_circ_0125344	circPCDH10	hsa_circ_PCDH10	PCDH10	pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"circPCDH10 (hsa_circ_0125344), derived from the PCDH10 gene, is up-regulated in pancreatic cancer tissues and cell lines and high expression is associated with poorer overall survival. Functionally, circPCDH10 promotes pancreatic cancer progression, including cell viability, proliferation, invasion, migration, metastasis, and xenograft tumor growth. Mechanistically, it mainly acts as a cytoplasmic ceRNA sponge for miR-338-3p to increase hTERT expression, while FUS is implicated in regulating its formation from the PCDH10 locus."	0.8621
34021307	Carcinogenesis	2021	"Circular RNA_0001495 increases Robo1 expression by sponging microRNA-527 to promote the proliferation, migration and invasion of bladder cancer cells."	hsa_circ_0001495	Circular RNA_0001495	hsa_circ_CCNB1	CCNB1	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circ_0001495 is up-regulated in bladder cancer tissues and cells and is associated with higher tumor grade, advanced T stage, and poorer overall survival. Functionally, it promotes BCa cell proliferation, migration, invasion, tumor growth, and metastasis by sponging miR-527 and increasing Robo1 expression."	0.8824
34021567	"Bioscience, biotechnology, and biochemistry"	2021	"Circ_0038467 regulates lipopolysaccharide-mediated cell proliferation, apoptosis, and inflammatory response by miR-195-5p/TLR4 axis through NF-kappaB pathway in MRC-5 cells."	hsa_circ_0038467	circ_0038467	hsa_circ_UQCRC2	UQCRC2	Infantile pneumonia / IP	MONDO:0005249	pneumonia	up-regulated	RT-qPCR	"circ_0038467 is up-regulated in LPS-induced human MRC-5 cells, an in vitro model related to infantile pneumonia. It aggravates LPS-induced cell injury by suppressing proliferation/cell viability and promoting apoptosis and inflammatory cytokine production, acting through the miR-195-5p/TLR4 axis and NF-kappaB pathway."	0.7204
34034499	Neoplasma	2021	Circ-sirt1 inhibits growth and invasion of gastric cancer by sponging miR-132-3p/miR-212-3p and upregulating sirt1 expression.	hsa_circ_0093887	circ-sirt1	hsa_circ_sirt1	sirt1	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"circ-sirt1 is downregulated in gastric cancer tissues and serum. It functions as a tumor suppressor by inhibiting GC cell proliferation, migration, invasion, and xenograft tumor growth, probably through sponging miR-132-3p/miR-212-3p and upregulating sirt1 expression."	0.5414
34077501	"Bioscience, biotechnology, and biochemistry"	2021	Circ_0091702 relieves lipopolysaccharide (LPS)-induced cell injury by regulating the miR-182/PDE7A axis in sepsis.	hsa_circ_0091702	Circ_0091702 / circVMA21	hsa_circ_VMA21	VMA21	sepsis	MONDO:0005229	bacterial infectious disease with sepsis	down-regulated	RT-qPCR	"circ_0091702 is down-regulated in LPS-induced HK2 cells and acts protectively in an in vitro sepsis cell injury model. Its overexpression alleviates LPS-induced cell injury by increasing viability and reducing apoptosis and inflammatory cytokine expression, mainly through the circ_0091702/miR-182/PDE7A axis."	0.6207
34092745	Endocrine journal	2021	CircHACE1 functions as a competitive endogenous RNA to curb differentiated thyroid cancer progression by upregulating Tfcp2L1 through adsorbing miR-346.	hsa_circ_0077514	circRNA HACE1	hsa_circ_HACE1	HACE1	differentiated thyroid cancer	MONDO:0015447	differentiated thyroid carcinoma	down-regulated	RT-qPCR; Microarray	"CircHACE1/hsa_circ_0077514 is downregulated in differentiated thyroid cancer tissues and cells, and low expression is associated with advanced clinicopathological features and poorer overall survival. Functionally, circHACE1 suppresses malignant phenotypes by sponging miR-346 and increasing Tfcp2L1 expression, thereby inhibiting proliferation, migration, invasion, and xenograft growth while promoting apoptosis and cell cycle arrest."	0.8557
34098776	Stem cells and development	2021	Gastric Cancer Cell-Derived Exosomes Can Regulate the Biological Functions of Mesenchymal Stem Cells by Inducing the Expression of Circular RNA circ_0004303.	hsa_circ_0004303	circ_0004303	hsa_circ_DDX60	DDX60	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"In this study, AGS gastric cancer cell-derived exosomes induced upregulation of hsa_circ_0004303 in human adipose-derived MSCs. Elevated circ_0004303 promoted MSC migration and invasion by sponging miR-148a-3p and increasing ALCAM expression, suggesting a mechanism by which gastric cancer cells may enhance MSC homing and tumor-promoting phenotypes."	0.7211
34100377	General physiology and biophysics	2021	"circ-PTTG1IP/miR-671-5p/TLR4 axis regulates proliferation, migration, invasion and inflammatory response of fibroblast-like synoviocytes in rheumatoid arthritis."	hsa_circ_0001200	circ-PTTG1IP	hsa_circ_PTTG1IP	PTTG1IP	rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"circ-PTTG1IP is up-regulated in RA synovial tissues and RA-FLSs. It promotes RA-FLS proliferation, migration, invasion and inflammatory cytokine secretion while suppressing apoptosis, mainly by acting as a cytoplasmic sponge for miR-671-5p to upregulate TLR4 expression."	0.742
34108309	Endocrine journal	2021	circRPS28 (hsa_circ_0049055) is a novel contributor for papillary thyroid carcinoma by regulating cell growth and motility via functioning as ceRNA for miR-345-5p to regulate frizzled family receptor 8 (FZD8).	hsa_circ_0049055	circRPS28	hsa_circ_RPS28	RPS28	papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circRPS28 (hsa_circ_0049055), derived from RPS28, is upregulated in PTC tissues and cell lines and is mainly localized in the cytoplasm. It promotes PTC cell growth, colony formation, migration, invasion and xenograft tumor growth while suppressing apoptosis, acting through a ceRNA axis in which circRPS28 sponges miR-345-5p to regulate FZD8."	0.8124
34150003	American journal of translational research	2021	"Circular RNA circ_0084927 regulates proliferation, apoptosis, and invasion of breast cancer cells via miR-142-3p/ERC1 pathway."	hsa_circ_0084927	circ_0084927			breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0084927 is up-regulated in breast cancer tissues and cell lines, and high expression is associated with poorer survival and adverse clinicopathological features. Functionally, circ_0084927 promotes breast cancer cell proliferation, colony formation, and invasion while suppressing apoptosis. Mechanistically, cytoplasmic circ_0084927 acts as a ceRNA for miR-142-3p to increase ERC1 expression, forming a circ_0084927/miR-142-3p/ERC1 regulatory axis."	0.835
34173806	Journal of cardiovascular pharmacology	2021	Circ_0084043 Facilitates High Glucose-Induced Retinal Pigment Epithelial Cell Injury by Activating miR-128-3p/TXNIP-Mediated Wnt/beta-Catenin Signaling Pathway.	hsa_circ_0084043	circ_0084043			Diabetic retinopathy / DR	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR	"In this in vitro diabetic retinopathy model, high glucose upregulated circ_0084043 in ARPE-19 retinal pigment epithelial cells. circ_0084043 promoted high glucose-induced cell injury by sponging miR-128-3p, increasing TXNIP, and activating Wnt/beta-Catenin signaling, leading to reduced viability and increased apoptosis and inflammation."	0.6207
34173813	Journal of cardiovascular pharmacology	2021	Carvedilol Protects Against the H2O2-induced Cell Damages in Rat Myoblasts by Regulating the Circ_NFIX/miR-125b-5p/TLR4 Signal Axis.		circRNA nuclear factor IX	rno_circ_NFIX	NFIX	acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR	"In this study, circ_NFIX was upregulated in H2O2-induced H9c2 cell injury and was downregulated by carvedilol treatment. circ_NFIX overexpression counteracted carvedilol-mediated protection by sponging miR-125b-5p and increasing TLR4 expression, thereby worsening cell-cycle inhibition, reduced proliferation, apoptosis, and LDH release in an AMI-related injury model."	0.6964
34174974	"Cellular and molecular biology (Noisy-le-Grand, France)"	2020	"Effect of paeonol on proliferation, apoptosis, migration, invasion and glutamine of gastric cancer cells via circSFMBT2/miR-665 axis."	hsa_circ_0017639	circSFMBT2	hsa_circ_SFMBT2	SFMBT2	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circSFMBT2 is up-regulated in gastric cancer tissues and HGC-27 cells. In paeonol-treated gastric cancer cells, circSFMBT2 overexpression counteracts paeonol-induced suppression of proliferation, migration, invasion and glutamine decomposition and reduces apoptosis, at least partly through negative regulation of miR-665."	0.8263
34230950	Sheng li xue bao : [Acta physiologica Sinica]	2021	[Circ_0001666 promotes the proliferation and inhibits apoptosis of non-small cell lung cancer cells by targeting the miR-330-5p/HMGA2 axis].	hsa_circ_0001666	circ_0001666			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0001666 is up-regulated in NSCLC tissues and cell lines. It promotes NSCLC cell proliferation and inhibits apoptosis by sponging miR-330-5p and indirectly up-regulating HMGA2, suggesting potential value as a biomarker and therapeutic target."	0.6956
34232319	Metallomics : integrated biometal science	2021	"A novel circular RNA, circPUS7 promotes cadmium-induced transformation of human bronchial epithelial cells by regulating Kirsten rat sarcoma viral oncogene homolog expression via sponging miR-770."		circPUS7 / novel_circ_0034496	hsa_circ_PUS7	PUS7	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; RNA-seq	"circPUS7 is a novel human PUS7-derived circRNA upregulated during cadmium-induced malignant transformation of BEAS-2B bronchial epithelial cells and in lung cancer cell lines. It promotes proliferation, migration, invasion, and anchorage-independent growth by sponging miR-770 and thereby increasing KRAS protein expression. Cadmium-associated upregulation of circPUS7 may involve increased NF90/NF110 and FUS protein levels."	0.756
34254931	Anti-cancer agents in medicinal chemistry	2022	Bioinformatics Analysis Predicts hsa_circ_0026337/miR-197-3p as a Potential Oncogenic ceRNA Network for Non-Small Cell Lung Cancers.	hsa_circ_0026337				non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	Microarray	"hsa_circ_0026337 was downregulated in NSCLC tissues based on GEO circRNA microarray datasets. The study predicts that hsa_circ_0026337 functions through a ceRNA network involving miR-197-3p and protein-coding targets such as MAPK8, IGF1R, GRB2, and ITCH, with low expression linked to poorer survival."	0.348
34254931	Anti-cancer agents in medicinal chemistry	2022	Bioinformatics Analysis Predicts hsa_circ_0026337/miR-197-3p as a Potential Oncogenic ceRNA Network for Non-Small Cell Lung Cancers.	hsa_circ_0043256				non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	Microarray	"hsa_circ_0043256 was downregulated in NSCLC tissues in three GEO circRNA microarray datasets. The study predicts that it sponges miR-1252-5p, miR-494-3p, and miR-558 and participates in a circRNA-miRNA-mRNA network linked to cancer-related pathways and possible diagnostic/prognostic value."	0.1768
34254931	Anti-cancer agents in medicinal chemistry	2022	Bioinformatics Analysis Predicts hsa_circ_0026337/miR-197-3p as a Potential Oncogenic ceRNA Network for Non-Small Cell Lung Cancers.	hsa_circ_0049271				non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	Microarray	"hsa_circ_0049271 was identified as a downregulated circRNA in NSCLC tissues using three GEO microarray datasets. Its functional role was predicted bioinformatically, mainly as a miRNA sponge with possible tumor suppressor relevance."	0.1768
34254931	Anti-cancer agents in medicinal chemistry	2022	Bioinformatics Analysis Predicts hsa_circ_0026337/miR-197-3p as a Potential Oncogenic ceRNA Network for Non-Small Cell Lung Cancers.	hsa_circ_0008234	hsa_circ_000823			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	Microarray	"hsa_circ_0008234 was identified as downregulated in NSCLC tissues from GEO microarray datasets. The study only provides bioinformatics-level evidence, predicting that it may bind multiple miRNAs and may participate in tumor suppressor-related ceRNA processes."	0.1768
34268958	Journal of B.U.ON. : official journal of the Balkan Union of Oncology	2021	The role of Circ_PRKCI/miR-24-3p in the metastasis of prostate cancer.		circ_PRKCI	hsa_circ_PRKCI	PRKCI	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circ_PRKCI is up-regulated in prostate cancer tissues and cell lines. Its high expression is associated with lymphatic and distant metastasis, and functional knockdown experiments indicate that it promotes prostate cancer cell proliferation, migration and invasion. Mechanistically, circ_PRKCI binds and negatively regulates miR-24-3p, forming a circ_PRKCI/miR-24-3p axis that contributes to malignant PCa phenotypes."	0.6479
34269180	Journal of biosciences	2021	"circRNA derived from CLSPN (circCLSPN) is an oncogene in human glioblastoma multiforme by regulating cell growth, migration and invasion via ceRNA pathway."	hsa_circ_0011591	circCLSPN	hsa_circ_CLSPN	CLSPN	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; Microarray	"circCLSPN is up-regulated in human GBM tissues and A172/LN18 cells. It promotes GBM cell growth, cell cycle progression, migration, invasion and xenograft tumor growth while suppressing apoptosis, acting through a circCLSPN-miR-370-3p-USP39 ceRNA pathway."	0.7951
34269702	Journal of cardiovascular pharmacology	2021	Circ-USP9X Inhibition Reduces Oxidized Low-density Lipoprotein-induced Endothelial Cell Injury via the microRNA 599/Chloride Intracellular Channel 4 Axis.	hsa_circ_0090231	circ-USP9X	hsa_circ_USP9X	USP9X	atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"circ-USP9X is upregulated in AS patients' serum and ox-LDL-induced HUVEC. It promotes ox-LDL-induced endothelial cell injury by sponging miR-599 and increasing CLIC4 expression, while circ-USP9X silencing improves viability, cell cycle progression and tube formation and reduces apoptosis, inflammation, oxidative stress and serum lipid abnormalities in AS models."	0.78
34269703	Journal of cardiovascular pharmacology	2021	Circ-PRKCI Alleviates Lipopolysaccharide-induced Human Kidney 2 Cell Injury by Regulating miR-106b-5p/GAB1 Axis.		circPRKCI	hsa_circ_PRKCI	PRKCI	sepsis-induced acute kidney injury	MONDO:0002492	acute kidney injury	down-regulated	RT-qPCR	"circPRKCI is down-regulated in sepsis patient serum and LPS-treated HK-2 cells. Its overexpression alleviates LPS-induced HK-2 cell apoptosis, inflammation and oxidative stress by sponging miR-106b-5p and increasing GAB1 expression, suggesting potential biomarker or therapeutic relevance in sepsis-induced AKI."	0.7032
34284545	Folia neuropathologica	2021	Hsa_circ_0001017 inhibits proliferation and metastasis via regulating the let-7g-3p/NDST3 axis in glioma.	hsa_circ_0001017	circ_0001017			glioma	MONDO:0021042	glioma	down-regulated	RT-qPCR	"Hsa_circ_0001017 is downregulated in glioma tissues and cell lines. It acts as a tumor-suppressive circRNA by inhibiting proliferation, migration, invasion, EMT and metastasis while promoting apoptosis. Mechanistically, it sponges hsa-let-7g-3p to regulate NDST3 in the hsa_circ_0001017/hsa-let-7g-3p/NDST3 axis."	0.705
34289738	Biomarkers in medicine	2021	Increased levels of circulating circular RNA (hsa_circ_0013587) may serve as a novel biomarker for pancreatic cancer.	hsa_circ_0013587	circ_0013587	hsa_circ_LRIG2	LRIG2	pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; Microarray	"hsa_circ_0013587 is a human LRIG2-derived circRNA that is up-regulated in pancreatic cancer tissues, pancreatic cancer cell lines, and plasma from pancreatic cancer patients. Its circulating expression shows diagnostic potential, including discrimination of patients from healthy controls and association with later clinical stage, tumor size, venous invasion, and lymphatic invasion. The study supports its role as a stable blood-based biomarker, but does not define a mechanistic regulatory axis."	0.6556
34291441	Histology and histopathology	2022	CircRIP2 promotes NSCLC progression by sponging for miR-671-5p to regulate FOXM1 expression.		CircRIP2	hsa_circ_RIP2		non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"CircRIP2 is up-regulated in NSCLC tissues and cell lines and high expression predicts poorer OS and DFS. Functionally, it promotes NSCLC cell growth, proliferation, migration and metastasis. Mechanistically, cytoplasmic circRIP2 sponges miR-671-5p to relieve repression of FOXM1, forming the circRIP2/miR-671-5p/FOXM1 regulatory axis."	0.8005
34305100	The Tohoku journal of experimental medicine	2021	Circular RNA circ_0046264 Suppresses Osteosarcoma Progression via microRNA-940/Secreted Frizzled Related Protein 1 Axis.	hsa_circ_0046264	circ_0046264	hsa_circ_P4HB	P4HB	osteosarcoma / OS	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; Microarray	"circ_0046264 is down-regulated in osteosarcoma tissues and cell lines and functions as a tumor suppressor. It mainly localizes in the cytoplasm, inhibits osteosarcoma cell proliferation, migration and invasion, and acts through a ceRNA mechanism involving miR-940 and SFRP1. Low circ_0046264 expression is associated with larger tumor diameter and positive or higher Ki67 expression."	0.7489
34306334	American journal of translational research	2021	Circular RNA circNEURL4 inhibits cell proliferation and invasion of papillary thyroid carcinoma by sponging miR-1278 and regulating LATS1 expression.		circLARP4 / hsa_circ_101057	hsa_circ_LARP4	LARP4	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; ISH; Microarray	"circLARP4 is a human LARP4-derived circRNA that is downregulated in gastric cancer tissues and cell lines. It mainly localizes in the cytoplasm and suppresses GC cell proliferation and invasion by sponging miR-424 and regulating the LATS1/YAP pathway. Clinically, higher circLARP4 expression is associated with longer overall survival and more favorable therapeutic outcome after oxaliplatin and 5-Fu chemotherapy."	0.874
34306340	American journal of translational research	2021	Circular RNA 0006602 in plasma exosomes: a new potential diagnostic biomarker for hepatocellular carcinoma.		exo_circ_ 0006602			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"Exo_circ_0006602 is up-regulated in plasma exosomes from HCC patients and shows diagnostic value superior to AFP and CEA, especially when combined with AFP. Functionally, exosomal exo_circ_0006602 promotes proliferation, migration and invasion of liver cancer cell lines and increases Snail expression."	0.6758
34306340	American journal of translational research	2021	Circular RNA 0006602 in plasma exosomes: a new potential diagnostic biomarker for hepatocellular carcinoma.		exo_ circ_0000690			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RNA-seq	"Exo_circ_0000690 was one of five up-regulated plasma exosomal circRNAs selected from RNA-seq screening in HCC patients. The paper did not report independent large-sample validation, diagnostic performance, mechanism, or functional assays for this circRNA."	0.1768
34306340	American journal of translational research	2021	Circular RNA 0006602 in plasma exosomes: a new potential diagnostic biomarker for hepatocellular carcinoma.		exo_circ_0005882			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RNA-seq	"Exo_circ_0005882 was one of five up-regulated plasma exosomal circRNAs selected from RNA-seq screening in HCC patients. The paper did not report independent large-sample validation, diagnostic performance, mechanism, or functional assays for this circRNA."	0.1768
34306340	American journal of translational research	2021	Circular RNA 0006602 in plasma exosomes: a new potential diagnostic biomarker for hepatocellular carcinoma.		exo_circ_ 0000128			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RNA-seq	"Exo_circ_0000128 was one of five up-regulated plasma exosomal circRNAs selected from RNA-seq screening in HCC patients. The paper did not report independent large-sample validation, diagnostic performance, mechanism, or functional assays for this circRNA."	0.1768
34306340	American journal of translational research	2021	Circular RNA 0006602 in plasma exosomes: a new potential diagnostic biomarker for hepatocellular carcinoma.		exo_circ_0008328			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RNA-seq	"Exo_circ_0008328 was one of five up-regulated plasma exosomal circRNAs selected from RNA-seq screening in HCC patients. The paper did not report independent large-sample validation, diagnostic performance, mechanism, or functional assays for this circRNA."	0.1768
34306346	American journal of translational research	2021	Circular RNA circUBE2D2 functions as an oncogenic factor in hepatocellular carcinoma sorafenib resistance and glycolysis.	hsa_circ_0006716	circUBE2D2	hsa_circ_UBE2D2	UBE2D2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circUBE2D2 is an up-regulated circRNA in HCC tissues and cells, and high expression is linked to poor patient survival. It promotes HCC glycolysis and sorafenib resistance by acting as a cytoplasmic sponge for miR-889-3p and regulating LDHA through the circUBE2D2/miR-889-3p/LDHA axis. Knockdown of circUBE2D2 suppresses xenograft tumor growth in vivo."	0.8222
34313249	Journal of biosciences	2021	Exosomal circRNA HIPK3 knockdown inhibited cell proliferation and metastasis in prostate cancer by regulating miR-212/BMI-1 pathway.		circHIPK3 / circRNA homeodomain-interacting protein kinase 3	hsa_circ_HIPK3	HIPK3	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"Exosomal circHIPK3 is up-regulated in serum exosomes from prostate cancer patients and in exosomes from PCa cells. It promotes PCa cell proliferation, migration, invasion, metastasis and tumor growth while suppressing apoptosis, mainly by sponging miR-212 and modulating BMI-1 expression through the miR-212/BMI-1 axis. Its serum exosomal expression also shows diagnostic potential for distinguishing PCa patients from healthy volunteers."	0.7126
34314478	Carcinogenesis	2021	CircRNA UBAP2 serves as a sponge of miR-1294 to increase tumorigenesis in hepatocellular carcinoma through regulating c-Myc expression.	hsa_circ_0003945	circUBAP2	hsa_circ_UBAP2	UBAP2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circUBAP2 (hsa_circ_0003945), derived from the human UBAP2 gene, is up-regulated in HCC tissues and high expression predicts poor OS and TTR. Functionally, it promotes proliferation, tumor growth, migration, invasion and EMT while inhibiting apoptosis. Mechanistically, cytoplasmic circUBAP2 sponges miR-1294 to increase c-MYC expression, forming a circUBAP2-miR-1294-c-MYC regulatory axis."	0.8556
34314629	Cancer biotherapy & radiopharmaceuticals	2022	Overexpression of circRNA circFAT1 in Endometrial Cancer Cells Increases Their Stemness by Upregulating miR-21 Through Methylation.		circFAT1	hsa_circ_FAT1		endometrial cancer / EC	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR; Microarray	"circFAT1 is upregulated in endometrial cancer tissues and functions as an oncogenic circRNA in this study. It promotes EC cell stemness by increasing miR-21 expression through reduced methylation of the miR-21 gene, and miR-21 inhibition suppresses the stemness-promoting effect of circFAT1."	0.6166
34321402	Journal of cardiovascular pharmacology	2021	CircSCAP Aggravates Oxidized Low-density Lipoprotein-induced Macrophage Injury by Upregulating PDE3B by miR-221-5p in Atherosclerosis.	hsa_circ_0001292	circSCAP / hsa_circRNA_103352 A	hsa_circ_SCAP	SCAP	atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR; Microarray	"CircSCAP is up-regulated in serum from AS patients and in ox-LDL-treated THP-1 cells. Functionally, circSCAP aggravates ox-LDL-induced macrophage injury by promoting lipid deposition, inflammation, oxidative stress, and apoptosis-related changes. Mechanistically, it sponges miR-221-5p to increase PDE3B expression and regulate NF-kappaB signaling."	0.7283
34339285	Cancer biotherapy & radiopharmaceuticals	2023	Circular RNAcirc_0076305 Promotes Cisplatin (DDP) Resistance of Non-Small Cell Lung Cancer Cells by Regulating ABCC1 Through miR-186-5p.	hsa_circ_0076305	circ_0076305			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0076305 is up-regulated in NSCLC serum exosomes, NSCLC tissues, and DDP-resistant NSCLC tissues and cells. It promotes cisplatin resistance by sponging miR-186-5p and increasing ABCC1 expression; knockdown of circ_0076305 improves DDP sensitivity in vitro and in a xenograft model."	0.7244
34340259	Journal of gastroenterology and hepatology	2021	Hsa_circ_0016788 regulates hepatocellular carcinoma progression via miR-506-3p/poly-adenosine diphosphate-ribose polymerase.	hsa_circ_0016788	circRNA_0016788	hsa_circ_TRIM11	TRIM11	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"hsa_circ_0016788 is up-regulated in HCC tissues and HCC cell lines. It promotes HCC progression by sponging miR-506-3p and increasing PARP14 expression, thereby enhancing glycolysis, proliferation, colony formation, invasion, and tumor growth while suppressing apoptosis. The study suggests that hsa_circ_0016788 may represent a potential therapeutic target for HCC."	0.8299
34345300	Oncology letters	2021	Upregulation of circular and linear METTL3 and USP3 in colorectal cancer.	hsa_circ_0000523	circ-METTL3	hsa_circ_METTL3	METTL3	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circMETTL3 is upregulated in leukocytes from patients with colorectal cancer. The study suggests that circMETTL3 may have potential as a non-invasive CRC biomarker, supported by RT-qPCR expression validation and ROC analysis."	0.4187
34345300	Oncology letters	2021	Upregulation of circular and linear METTL3 and USP3 in colorectal cancer.	hsa_circ_0002138	circUSP3	hsa_circ_USP3	USP3	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circUSP3 is upregulated in leukocytes from patients with colorectal cancer and correlates positively with linear USP3 expression in the CRC group. Unlike circMETTL3, its ROC analysis was not statistically significant, so its value as a CRC biomarker remains limited in this study."	0.4187
34345300	Oncology letters	2021	Upregulation of circular and linear METTL3 and USP3 in colorectal cancer.	hsa_circ_0001649	circSHPRH	hsa_circ_SHPRH	SHPRH	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circSHPRH was tested during the initial RT-qPCR candidate analysis and was upregulated in a small CRC-versus-control leukocyte subset. It was not selected for further analysis, and no mechanism or clinical diagnostic performance was reported for this circRNA."	0.2995
34348265	"Cells, tissues, organs"	2021	The Inhibitory Effect of miR-345 on Glioma Progression Is Closely Related to circRNA-hsa_circ_0073237 and HDGF.	hsa_circ_0073237				glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"hsa_circ_0073237 is up-regulated in glioma tissues and glioma cell lines and is mainly cytoplasmic. It promotes glioma cell viability and invasion while inhibiting apoptosis by sponging miR-345 and up-regulating HDGF, suggesting the hsa_circ_0073237/miR-345/HDGF axis as a potential therapeutic target."	0.7283
34348465	Neoplasma	2021	Depletion of circRNA circ_CDK14 inhibits osteosarcoma progression by regulating the miR-520a-3p/GAB1 axis.	hsa_circ_0001721	circ_CDK14	hsa_circ_CDK14	CDK14	Osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ_CDK14/hsa_circ_0001721 is up-regulated in osteosarcoma tissues and cell lines. It promotes OS progression by acting as a miR-520a-3p sponge and regulating the downstream target GAB1; knockdown of circ_CDK14 inhibits proliferation, migration, invasion and xenograft tumor growth while inducing apoptosis."	0.7421
34350833	General physiology and biophysics	2021	circ_VMA21 protects WI-38 cells against LPS-induced apoptotic and inflammatory injury by acting on the miR-409-3p/KLF4 axis.	hsa_circ_0091702	circ_VMA21 / circRNA vacuolar ATPase assembly factor	hsa_circ_VMA21	VMA21	pneumonia	MONDO:0005249	pneumonia	down-regulated	RT-qPCR	"circ_VMA21 is downregulated in serum from infantile pneumonia patients and in LPS-treated WI-38 cells. Functionally, circ_VMA21 overexpression protects WI-38 cells from LPS-induced injury by promoting cell cycle progression and proliferation while inhibiting apoptosis and inflammatory cytokine production. Mechanistically, circ_VMA21 sponges miR-409-3p to upregulate KLF4, forming a circ_VMA21/miR-409-3p/KLF4 regulatory axis."	0.7595
34369900	Journal of cardiovascular pharmacology	2021	Circ_USP36 Silencing Attenuates Oxidized Low-Density Lipoprotein-Induced Dysfunction in Endothelial Cells in Atherosclerosis Through Mediating miR-197-3p/ROBO1 Axis.	hsa_circ_0003204	circRNA ubiquitin specific peptidase 36 / circ_USP36	hsa_circ_USP36	USP36	atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"circ_USP36 is up-regulated in serum from AS patients and in ox-LDL-induced HUVECs. Functionally, circ_USP36 promotes endothelial dysfunction by inhibiting proliferation and cell cycle progression while enhancing apoptosis, inflammation, and cell death. Mechanistically, it acts as a miR-197-3p sponge to increase ROBO1 expression, forming a circ_USP36/miR-197-3p/ROBO1 regulatory axis."	0.7595
34370552	Molecular and cellular biology	2021	Circular RNA circ-ERBB2 Elevates the Warburg Effect and Facilitates Triple-Negative Breast Cancer Growth by the MicroRNA 136-5p/Pyruvate Dehydrogenase Kinase 4 Axis.	hsa_circ_0007766	circ-ERBB2	hsa_circ_ERBB2	ERBB2	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ-ERBB2 is up-regulated in TNBC tissues and cells and high expression predicts poor overall survival. Functionally, circ-ERBB2 promotes glycolytic Warburg metabolism, proliferation, migration, invasion and tumor growth while suppressing apoptosis. Mechanistically, cytoplasmic circ-ERBB2 acts as a ceRNA sponge for miR-136-5p to increase PDK4 expression."	0.8769
34376137	Recent patents on anti-cancer drug discovery	2022	Circular RNA NF1-419 Inhibits Proliferation and Induces Apoptosis by Regulating Lipid Metabolism in Astroglioma Cells.	hsa_circ_0042880	circular NF1-419	hsa_circ_NF1	NF1	astroglioma	MONDO:0021636	astrocytic tumor	unknown	RT-qPCR; RNA-seq	"circNF1-419 was selected as a target after G. lucidum extract L3 increased its expression in U87 astroglioma cells. Overexpression of circNF1-419 inhibited astroglioma cell growth and xenograft tumor growth, promoted apoptosis, and altered lipid metabolism through glycerophospholipid metabolism and retrograde endocannabinoid signaling with changes in metabolic regulators including L-VOCC, PLCbeta3, Mucin1, CAT4, CAT1, AKAP4, and PTDSS1. The study proposes circNF1-419 as a potential therapeutic target for astroglioma."	0.7296
34377235	American journal of translational research	2021	CircRPPH1 serves as a sponge for miR-296-5p to enhance progression of breast cancer by regulating FOXP4 expression.	hsa_circ_0000514	circRPPH1	hsa_circ_RPPH1	RPPH1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circRPPH1 is up-regulated in breast cancer tissues and cells and its high expression is associated with poor prognosis, lymph node metastasis, and higher TNM stage. Functionally, circRPPH1 promotes breast cancer cell proliferation, migration, invasion, glycolysis, and xenograft tumor growth. Mechanistically, circRPPH1 sponges miR-296-5p to increase FOXP4 expression, forming a circRPPH1/miR-296-5p/FOXP4 regulatory axis."	0.8568
34383411	Clinical laboratory	2021	Five circRNAs Serve as Potential Diagnostic and Prognostic Biomarkers in Lung Adenocarcinoma.		hsa_circ_001010			lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"hsa_circ_001010 was up-regulated in lung adenocarcinoma serum and tissues and showed diagnostic and prognostic value. Functional overexpression inhibited A549 proliferation and promoted apoptosis, suggesting a tumor-suppressive functional effect in vitro despite its high expression being associated with poorer survival in the Results section."	0.6155
34383411	Clinical laboratory	2021	Five circRNAs Serve as Potential Diagnostic and Prognostic Biomarkers in Lung Adenocarcinoma.			hsa_circ_ZNF609	ZNF609	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"hsa_circ-ZNF609 was up-regulated in lung adenocarcinoma serum and tissues and had diagnostic and prognostic relevance. Overexpression inhibited A549 proliferation and promoted apoptosis, suggesting a tumor-suppressive functional effect in vitro despite high expression being associated with poorer survival in the Results section."	0.6155
34383411	Clinical laboratory	2021	Five circRNAs Serve as Potential Diagnostic and Prognostic Biomarkers in Lung Adenocarcinoma.			hsa_circ_CRIMI1	CRIMI1	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR	"hsa_circ-CRIMI1 was down-regulated in lung adenocarcinoma serum and tissues. Its low expression correlated with aggressive clinicopathological features and poorer survival, while knockdown inhibited A549 proliferation and promoted apoptosis, supporting a pro-tumor functional role."	0.6155
34383411	Clinical laboratory	2021	Five circRNAs Serve as Potential Diagnostic and Prognostic Biomarkers in Lung Adenocarcinoma.			hsa_circ_EPB41L2	EPB41L2	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR	"hsa_circ-EPB41L2 was down-regulated in lung adenocarcinoma serum and tissues. Lower expression was linked to advanced clinicopathological features and poorer survival, and silencing inhibited A549 proliferation and facilitated apoptosis, suggesting a pro-tumor role."	0.6155
34383411	Clinical laboratory	2021	Five circRNAs Serve as Potential Diagnostic and Prognostic Biomarkers in Lung Adenocarcinoma.	hsa_circ_0072309				lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR	"hsa_circ_0072309 was down-regulated in lung adenocarcinoma serum and tissues and showed diagnostic and prognostic significance. Lower expression correlated with aggressive clinical features and poorer survival, while knockdown reduced A549 proliferation and promoted apoptosis, suggesting a pro-tumor functional role."	0.6155
34385309	Proceedings of the National Academy of Sciences of the United States of America	2021	CircURI1 interacts with hnRNPM to inhibit metastasis by modulating alternative splicing in gastric cancer.	hsa_circ_0000921	circURI1	hsa_circ_URI1	URI1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"CircURI1 is a human URI1-derived circRNA that is up-regulated in gastric cancer tissues compared with adjacent nontumor tissues. Despite its increased expression, circURI1 functions as an anti-metastatic circRNA by inhibiting GC cell migration, invasion, and in vivo lung metastasis. Mechanistically, nuclear circURI1 binds and sequesters the RBP hnRNPM to modulate alternative splicing of metastasis-related genes, including VEGFA."	0.853
34387590	Anti-cancer drugs	2022	CircCUL2 suppresses retinoblastoma cells by regulating miR-214-5p/E2F2 Axis.		circCUL2	hsa_circ_CUL2	CUL2	retinoblastoma / RB	MONDO:0008380	retinoblastoma	down-regulated	RT-qPCR	"CircCUL2 is down-regulated in retinoblastoma tissues and cell lines. Functionally, circCUL2 suppresses retinoblastoma cell proliferation, invasion and migration by negatively regulating miR-214-5p and relieving miR-214-5p-mediated repression of E2F2, suggesting potential therapeutic relevance."	0.6521
34387591	Anti-cancer drugs	2022	Circ_KIAA1199 inhibits MSI1 degradation by targeting miR-34c-5p to drive the malignant cell behaviors and tumor growth of colorectal cancer.	hsa_circ_0004585		hsa_circ_KIAA1199	KIAA1199	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"Circ_KIAA1199 is up-regulated in colorectal cancer tissues and cells and acts as an oncogenic circRNA. Its knockdown suppresses CRC cell proliferation, survival, migration, invasion and xenograft tumor growth, partly through release of miR-34c-5p and consequent inhibition of MSI1."	0.8175
34387598	Anti-cancer drugs	2022	Circ_0085495 knockdown reduces adriamycin resistance in breast cancer through miR-873-5p/integrin beta1 axis.	hsa_circ_0085495		hsa_circ_TMEM65	TMEM65	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0085495 is upregulated in ADM-resistant breast cancer cells and promotes chemoresistance, proliferation, migration, invasion and tumor growth while suppressing apoptosis. Mechanistically, it acts as a ceRNA sponge for miR-873-5p, thereby increasing integrin beta1 expression. Knockdown of circ_0085495 reduces ADM resistance, suggesting potential therapeutic value in breast cancer."	0.7451
34387599	Anti-cancer drugs	2022	"CircFOXM1 silencing represses cell proliferation, migration and invasion by regulating miR-515-5p/ADAM10 axis in prostate cancer."		Circular FOXM1 / circFOXM1	hsa_circ_FOXM1	FOXM1	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circFOXM1 is upregulated in prostate cancer tissues and cells and high expression predicts poorer overall survival. Functionally, circFOXM1 promotes PCa proliferation, migration, invasion, cell cycle progression and tumor growth. Mechanistically, it acts as a ceRNA sponge for miR-515-5p to regulate ADAM10 expression through the circFOXM1/miR-515-5p/ADAM10 axis."	0.7891
34387601	Anti-cancer drugs	2022	Downregulation of circ-SFMBT2 blocks the development of gastric cancer by targeting the miR-885-3p/CHD7 pathway.	hsa_circ_0017639	circ-SFMBT2 / circ_0017639	hsa_circ_SFMBT2	SFMBT2	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ-SFMBT2 is up-regulated in gastric cancer tissues and cells. It promotes malignant phenotypes and tumor growth by sponging miR-885-3p, thereby increasing CHD7 expression and activating Wnt/beta-catenin signaling. Knockdown of circ-SFMBT2 suppresses gastric cancer cell viability, colony formation, migration, invasion and oxidative stress while inducing apoptosis."	0.8006
34387608	Anti-cancer drugs	2022	Circular RNA circ-RNF121 contributes to cisplatin (DDP) resistance of non-small-cell lung cancer cells by regulating the miR-646/SOX4 axis.	hsa_circ_0023404	circ-RNF121	hsa_circ_RNF121	RNF121	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ-RNF121 is upregulated in NSCLC tissues, especially chemo-resistant NSCLC tissues, and in DDP-resistant NSCLC cell lines. It promotes cisplatin resistance and malignant phenotypes by sponging miR-646 to increase SOX4 expression; silencing circ-RNF121 enhances DDP sensitivity in vitro and in a xenograft model."	0.7053
34387609	Anti-cancer drugs	2022	"Circular RNA circ_0008450 regulates the proliferation, migration, invasion, apoptosis and chemosensitivity of CDDP-resistant nasopharyngeal carcinoma cells by the miR-338-3p/SMAD5 axis."	hsa_circ_0008450		hsa_circ_CMTM3	CMTM3	nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"circ_0008450 is up-regulated in CDDP-resistant nasopharyngeal carcinoma tissues and cells. It promotes malignant phenotypes and cisplatin resistance by sponging miR-338-3p to regulate SMAD5 expression and activate PI3K/AKT signaling. Silencing circ_0008450 suppresses proliferation, migration, invasion and tumor growth while enhancing apoptosis and CDDP sensitivity."	0.7052
34387610	Anti-cancer drugs	2022	Circular RNA circ-CCT3 promotes bortezomib resistance in multiple myeloma via modulating miR-223-3p/BRD4 axis.	hsa_circ_0000142		hsa_circ_CCT3	CCT3	multiple myeloma / MM	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR	"circ-CCT3 is up-regulated in multiple myeloma, especially in bortezomib-resistant patients and cells. It promotes bortezomib resistance by sponging miR-223-3p and upregulating BRD4; circ-CCT3 knockdown increases bortezomib sensitivity, induces apoptosis and cell cycle arrest, and inhibits proliferation and migration."	0.7181
34388244	Laboratory medicine	2022	Diagnostic Value of Circular RNA hsa_circ_0002874 Expression in Peripheral Blood of Patients with Gastric Cancer.	hsa_circ_0002874	hsa_circ_GLIS3_003	hsa_circ_GLIS3	GLIS3	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0002874 is up-regulated in plasma, gastric cancer tissues, and gastric cancer cell lines. Its plasma and tissue expression correlates with TNM stage and lymph node metastasis, supporting its potential use as a less invasive diagnostic and clinicopathological biomarker for gastric cancer. The study did not define a molecular mechanism or functional regulatory axis."	0.4679
34402683	Cancer biotherapy & radiopharmaceuticals	2022	circRNA RPPH1 Facilitates the Aggravation of Breast Cancer Development by Regulating miR-542-3p/ARHGAP1 Pathway.	hsa_circ_0000515		hsa_circ_RPPH1	RPPH1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_RPPH1 is up-regulated in breast cancer tissues and cell lines. It functions as an oncogenic circRNA by sponging miR-542-3p and thereby increasing ARHGAP1 expression, which promotes proliferation, migration, invasion, EMT, and xenograft tumor growth while suppressing apoptosis."	0.7595
34403373	The Journal of clinical investigation	2021	Circular RNA cia-MAF drives self-renewal and metastasis of liver tumor-initiating cells via transcription factor MAFF.		cia-MAF / circRNA activating MAFF			liver cancer	MONDO:0002691	liver cancer	up-regulated	RT-qPCR; Northern Blot; ISH; RNA-seq	"cia-MAF is an up-regulated circRNA in liver cancer and liver TICs. It promotes TIC self-renewal, tumor initiation, invasion, metastasis, and tumor propagation by binding the MAFF promoter and recruiting the TIP60 chromatin remodeling complex to activate MAFF transcription. Clinically, high cia-MAF expression correlates with more severe disease features, relapse, and prognosis, supporting the cia-MAF/MAFF axis as a therapeutic target in HCC."	0.8898
34403373	The Journal of clinical investigation	2021	Circular RNA cia-MAF drives self-renewal and metastasis of liver tumor-initiating cells via transcription factor MAFF.		cia-MAF / circRNA activating MAFF			liver cancer	MONDO:0002691	liver cancer	up-regulated	RT-qPCR; Northern Blot; ISH; RNA-seq	"cia-MAF is an up-regulated circRNA in liver cancer and liver TICs. It promotes TIC self-renewal, tumor initiation, invasion, metastasis, and tumor propagation by binding the MAFF promoter and recruiting the TIP60 chromatin remodeling complex to activate MAFF transcription. Clinically, high cia-MAF expression correlates with more severe disease features, relapse, and prognosis, supporting the cia-MAF/MAFF axis as a therapeutic target in HCC."	0.8898
34407047	Anti-cancer drugs	2022	CircASAP1 promotes the development of cervical cancer through sponging miR-338-3p to upregulate RPP25.	hsa_circ_0085616	circASAP1	hsa_circ_ASAP1	ASAP1	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circASAP1 is upregulated in cervical cancer tissues and cells and acts as an oncogenic circRNA. It promotes proliferation, migration, invasion, cell cycle progression, and xenograft tumor growth while suppressing apoptosis, mainly by sponging miR-338-3p to increase RPP25 expression. The study proposes circASAP1 as a potential diagnostic biomarker for cervical cancer."	0.795
34407049	Anti-cancer drugs	2022	Circ_0003732 promotes osteosarcoma progression through regulating miR-377-3p/CPEB1 axis and Wnt/beta-catenin signaling pathway.	hsa_circ_0003732	circ_0003732			osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ_0003732 is up-regulated in osteosarcoma tissues and cells and functions as a tumor-promoting circRNA. It promotes proliferation, migration, invasion and in vivo tumor growth while inhibiting apoptosis, mainly by sponging miR-377-3p to increase CPEB1 expression and activate Wnt/beta-catenin signaling."	0.786
34407050	Anti-cancer drugs	2022	Circ_0005875 sponges miR-502-5p to promote renal cell carcinoma progression through upregulating E26 transformation specific-1.	hsa_circ_0005875	circ_0005875			renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR	"Circ_0005875 is upregulated in RCC tissues and cell lines. It promotes RCC malignant progression by sponging miR-502-5p and increasing ETS1 expression, thereby enhancing proliferation, migration, invasion, cell cycle progression, EMT and xenograft tumor growth while suppressing apoptosis. The study suggests circ_0005875 as a potential therapeutic target for RCC."	0.8175
34407051	Anti-cancer drugs	2022	Hsa_circ_0014879 regulates the radiosensitivity of esophageal squamous cell carcinoma through miR-519-3p/CDC25A axis.	hsa_circ_0014879	circRNA_100367	hsa_circ_DCAF8	DCAF8	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"hsa_circ_0014879 is upregulated in radio-resistant ESCC tissues and cells. It promotes radioresistance and malignant phenotypes including proliferation, migration, invasion and EMT, while its knockdown enhances radiosensitivity. Mechanistically, hsa_circ_0014879 sponges miR-519-3p to upregulate CDC25A in the miR-519-3p/CDC25A axis."	0.6536
34409798	Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology	2021	circ_0005379 inhibits the progression of oral squamous cell carcinoma by regulating the miR-17-5p/acyl-CoA oxidase 1 axis.	hsa_circ_0005379	circ_0005379			oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR	"circ_0005379 is down-regulated in OSCC tissues and SCC15 cells. Its overexpression suppresses OSCC cell proliferation, migration, invasion and xenograft tumor growth while promoting apoptosis, likely through sponging miR-17-5p to increase ACOX1 expression. The study proposes circ_0005379 as a potential molecular therapeutic target for OSCC."	0.7548
34410163	The International journal of biological markers	2021	Circ_0006174 promotes colorectal cancer progression by sponging microRNA-142-3p and regulating X-linked inhibitor of apoptosis expression.	hsa_circ_0006174	circRNA_0006174	hsa_circ_RAD23B	RAD23B	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"Circ_0006174 is an up-regulated RAD23B-derived circRNA in human colorectal cancer tissues and cell lines. It functions as an oncogenic circRNA that promotes proliferation, migration and invasion while suppressing apoptosis, mainly through sponging miR-142-3p and increasing XIAP expression. Its high expression is associated with unfavorable clinicopathological characteristics, including enlarged tumor volume and advanced TNM stage."	0.7295
34414414	Endocrinology	2021	Hsa_circ_0023990 Promotes Tumor Growth and Glycolysis in Dedifferentiated TC via Targeting miR-485-5p/FOXM1 Axis.	hsa_circ_0023990		hsa_circ_NOX4	NOX4	thyroid cancer / TC	MONDO:0002108	thyroid cancer	up-regulated	RT-qPCR	"hsa_circ_0023990 is upregulated in thyroid cancer, especially dedifferentiated thyroid cancer tissues and cell lines. It promotes proliferation, cell-cycle progression, glycolysis, and xenograft tumor growth by sponging miR-485-5p and increasing FOXM1 expression. The study suggests hsa_circ_0023990 as a potential therapeutic target for dedifferentiated thyroid cancer."	0.7375
34419960	Anti-cancer drugs	2022	Circ_0027089 regulates NACC1 by targeting miR-136-5p to aggravate the development of hepatitis B virus-related hepatocellular carcinoma.	hsa_circ_0027089	circ_0027089	hsa_circ_PTGES3		hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"Circ_0027089 is up-regulated in HBV-related HCC tissues and cell lines and acts as an oncogenic circRNA. It promotes proliferation, cell cycle progression, migration, invasion and xenograft tumor growth while suppressing apoptosis, mainly through the circ_0027089/miR-136-5p/NACC1 ceRNA axis."	0.7053
34423784	Journal of biosciences	2021	Knockdown of circ_0008344 contributes to radiosensitization in glioma via miR-433-3p/RNF2 axis.	hsa_circ_0008344	circ_0008344			glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ_0008344 is up-regulated in glioma, especially radioresistant glioma tissues, and high expression is associated with poor prognosis. Mechanistically, circ_0008344 sponges miR-433-3p to increase RNF2 expression, thereby promoting radioresistance; its knockdown enhances radiosensitivity, increases apoptosis and DNA damage, and suppresses tumor growth in vivo."	0.7396
34427642	Inflammatory bowel diseases	2022	Circular RNA HECTD1 Mitigates Ulcerative Colitis by Promoting Enterocyte Autophagy Via miR-182-5p/HuR Axis.		Circular RNA HECTD1 / circHECTD1	hsa_circ_HECTD1	HECTD1	Ulcerative colitis / UC	MONDO:0005101	ulcerative colitis	down-regulated	RT-qPCR	"circHECTD1 is down-regulated in UC colonic mucosal tissues and in experimental UC/inflammation models. Its overexpression suppresses inflammatory cytokines and NLRP3 inflammasome activation, promotes autophagy, and alleviates DSS-induced colitis via a miR-182-5p/HuR-dependent mechanism involving AMPK/mTOR signaling."	0.7548
34435479	Journal of biological regulators and homeostatic agents	2021	CircRNA (circ_0008057) promotes uremic serum-mediated proliferation and migration of vascular smooth muscle cells via miR-370/PLk1 signaling pathway.	hsa_circ_0008057	circ_0008057			end-stage renal disease	MONDO:0005300	chronic kidney disease	up-regulated	RT-qPCR; Microarray	"circ_0008057 is up-regulated in uremic serum-treated human vascular smooth muscle cells. The study indicates that circ_0008057 promotes VSMC viability/proliferation and migration through a miR-370/PLK1 regulatory mechanism, supporting its potential relevance to uremia-related vascular disease."	0.6585
34437823	"Cell cycle (Georgetown, Tex.)"	2021	Hsa_circ_0006232 promotes laryngeal squamous cell cancer progression through FUS-mediated EZH2 stabilization.	hsa_circ_0006232				laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0006232 is up-regulated in LSCC cells and functions as a tumor-promoting circRNA. It promotes LSCC cell proliferation, migration, invasion, and xenograft tumor growth through interaction with the RNA-binding protein FUS, leading to EZH2 stabilization/expression and suppression of PTEN. The study suggests hsa_circ_0006232 as a potential therapeutic target for LSCC."	0.6314
34438395	Nephron	2021	Circ_RASGEF1B Promotes LPS-Induced Apoptosis and Inflammatory Response by Targeting MicroRNA-146a-5p/Pdk1 Axis in Septic Acute Kidney Injury Cell Model.		circ_RASGEF1B / circular RNA RasGEF domain family member 1B	mmu_circ_RASGEF1B	RASGEF1B	septic acute kidney injury	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR	"In this study, circ_RASGEF1B was up-regulated in LPS-induced septic AKI models in TCMK-1 cells and mice. It aggravated LPS-induced renal tubular epithelial cell injury by promoting apoptosis and inflammatory cytokine release and reducing cell viability, acting through the circ_RASGEF1B/miR-146a-5p/Pdk1 ceRNA axis."	0.7216
34438465	The journal of gene medicine	2021	Hsa_circ_0040809 regulates colorectal cancer development by upregulating methyltransferase DNMT1 via targeting miR-515-5p.	hsa_circ_0040809	circ_0040809			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circ_0040809 is up-regulated in colorectal cancer tissues and cell lines, and high expression is associated with shorter overall survival. Functionally, it promotes CRC cell proliferation and migration and suppresses apoptosis. Mechanistically, circ_0040809 acts as a miR-515-5p sponge to increase DNMT1 expression, supporting malignant CRC phenotypes."	0.7474
34445896	Phytopathology	2022	Exonic Circular RNAs Are Involved in Arabidopsis Immune Response Against Bacterial and Fungal Pathogens and Function Synergistically with Corresponding Linear RNAs.		circR194	ath_circ_AT3G29185	AT3G29185	Pseudomonas syringae infection	MONDO:0005141	Pseudomonas infection	dysregulated	RT-qPCR; RNA-seq	"circR194 is an Arabidopsis exonic circRNA from AT3G29185/BFA1. It is dysregulated after pathogen challenge and negatively influences immune response to Pst avrRpt2, apparently acting synergistically with its corresponding linear RNA."	0.4943
34445896	Phytopathology	2022	Exonic Circular RNAs Are Involved in Arabidopsis Immune Response Against Bacterial and Fungal Pathogens and Function Synergistically with Corresponding Linear RNAs.		circR1998	ath_circ_AT1G79380	AT1G79380	Pseudomonas syringae infection	MONDO:0005141	Pseudomonas infection	up-regulated	RT-qPCR; RNA-seq	"circR1998 is an Arabidopsis exonic circRNA from AT1G79380. Its expression is induced by both virulent and avirulent Pst infection, suggesting involvement in pathogen-response biology, but no detailed functional mechanism was tested."	0.4943
34445896	Phytopathology	2022	Exonic Circular RNAs Are Involved in Arabidopsis Immune Response Against Bacterial and Fungal Pathogens and Function Synergistically with Corresponding Linear RNAs.		circR2812	ath_circ_AT1G59870	AT1G59870	Pseudomonas syringae infection	MONDO:0005141	Pseudomonas infection	up-regulated	RT-qPCR; RNA-seq	"circR2812 is an Arabidopsis exonic circRNA from AT1G59870. It is dramatically induced after Pst avrRpt2 infection, supporting an association with avirulent bacterial pathogen response."	0.4943
34445896	Phytopathology	2022	Exonic Circular RNAs Are Involved in Arabidopsis Immune Response Against Bacterial and Fungal Pathogens and Function Synergistically with Corresponding Linear RNAs.		circR3177	ath_circ_AT1G70520	AT1G70520	Pseudomonas syringae infection	MONDO:0005141	Pseudomonas infection	up-regulated	RT-qPCR; RNA-seq	"circR3177 is an Arabidopsis exonic circRNA from AT1G70520. Its expression is induced by both Pst DC3000 and Pst avrRpt2 infections, indicating pathogen-responsive dysregulation."	0.4943
34445896	Phytopathology	2022	Exonic Circular RNAs Are Involved in Arabidopsis Immune Response Against Bacterial and Fungal Pathogens and Function Synergistically with Corresponding Linear RNAs.		circR3574	ath_circ_AT1G70740	AT1G70740	Pseudomonas syringae infection	MONDO:0005141	Pseudomonas infection	up-regulated	RT-qPCR; RNA-seq	"circR3574 is an Arabidopsis exonic circRNA from AT1G70740. It is induced by both Pst DC3000 and Pst avrRpt2 infections, suggesting pathogen-responsive expression."	0.4943
34445896	Phytopathology	2022	Exonic Circular RNAs Are Involved in Arabidopsis Immune Response Against Bacterial and Fungal Pathogens and Function Synergistically with Corresponding Linear RNAs.		circR4022	ath_circ_AT1G19860	AT1G19860	Pseudomonas syringae infection	MONDO:0005141	Pseudomonas infection	up-regulated	RT-qPCR; RNA-seq	"circR4022 is an Arabidopsis exonic circRNA generated from AT1G19860. It is induced by Pst infection, negatively affects immune response to Pst avrRpt2, and contributes to salt-stress tolerance, apparently acting synergistically with its linear RNA counterpart."	0.4943
34445896	Phytopathology	2022	Exonic Circular RNAs Are Involved in Arabidopsis Immune Response Against Bacterial and Fungal Pathogens and Function Synergistically with Corresponding Linear RNAs.		circR6142	ath_circ_AT3G63190	AT3G63190	Pseudomonas syringae infection	MONDO:0005141	Pseudomonas infection	down-regulated	RT-qPCR; RNA-seq	"circR6142 is an Arabidopsis exonic circRNA from AT3G63190. It is suppressed by both virulent and avirulent Pst infection, indicating pathogen-responsive down-regulation."	0.4943
34445896	Phytopathology	2022	Exonic Circular RNAs Are Involved in Arabidopsis Immune Response Against Bacterial and Fungal Pathogens and Function Synergistically with Corresponding Linear RNAs.		circR11208	ath_circ_AT5G26340	AT5G26340	Pseudomonas syringae infection	MONDO:0005141	Pseudomonas infection	up-regulated	RT-qPCR; RNA-seq	"circR11208 is an Arabidopsis exonic circRNA generated from AT5G26340/STP3/AtSTP13. It is induced by bacterial and fungal pathogen challenges, positively contributes to B. cinerea resistance and salt tolerance, and appears to function synergistically with its linear RNA counterpart."	0.4943
34459207	Neoplasma	2021	CircSEC24A promotes tumor progression through sequestering miR-455-3p in hepatocellular carcinoma.	hsa_circ_0003528	circSEC24A / Circular RNA circSEC24 Homolog A	hsa_circ_SEC24A	SEC24A	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circSEC24A is up-regulated in HCC tissues and cells, and high expression is associated with shorter patient survival. Functionally, circSEC24A promotes HCC tumor growth, proliferation, metastasis, invasion and EMT while suppressing apoptosis, mainly by sponging miR-455-3p to increase PPM1F expression."	0.8354
34459455	Anti-cancer drugs	2022	Circular noncoding RNA circ_0007334 sequestrates miR-577 to derepress KLF12 and accelerate colorectal cancer progression.	hsa_circ_0007334	circ_0007334	hsa_circ_MBOAT2	MBOAT2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0007334 is upregulated in CRC tissues, CRC cell lines and CRC cell-derived exosomes. It promotes CRC progression by sponging miR-577 and increasing KLF12 expression, thereby enhancing cell growth, migration, invasion, metastasis and angiogenesis. Knockdown of cellular or exosomal circ_0007334 suppresses tumor growth and angiogenesis in vivo, supporting its potential as a therapeutic target."	0.8443
34459457	Anti-cancer drugs	2022	Circular RNA circ_0000592 elevates ANXA4 expression via sponging miR-1179 to facilitate tumor progression in gastric cancer.	hsa_circ_0000592	circ_0000592	hsa_circ_MGA	MGA	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"Circ_0000592 is up-regulated in gastric cancer tissues and cell lines and correlates with advanced TNM stage. It promotes GC progression by sponging miR-1179 and increasing ANXA4 expression, thereby enhancing proliferation, migration, invasion, glycolysis and tumor growth in vivo."	0.7537
34474408	Nephron	2022	"Circ_0000491 Promotes Apoptosis, Inflammation, Oxidative Stress, and Fibrosis in High Glucose-Induced Mesangial Cells by Regulating miR-455-3p/Hmgb1 Axis."		circ_0000491 / circHOMER1	hsa_circ_HOMER1	HOMER1	Diabetic nephropathy / DN	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"circ_0000491/mmu_circ_0000491 is up-regulated in diabetic nephropathy mouse kidney tissues, high glucose-induced SV40-MES13 cells, and serum of DN patients. It promotes DN-related mesangial cell injury by enhancing apoptosis, inflammation, oxidative stress, and fibrosis through the miR-455-3p/Hmgb1 axis. Its circulating expression may be associated with DN progression."	0.7785
34474408	Nephron	2022	"Circ_0000491 Promotes Apoptosis, Inflammation, Oxidative Stress, and Fibrosis in High Glucose-Induced Mesangial Cells by Regulating miR-455-3p/Hmgb1 Axis."	mmu_circ_0000491	circ_0000491 / circHOMER1	mmu_circ_HOMER1	HOMER1	Diabetic nephropathy / DN	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"circ_0000491/mmu_circ_0000491 is up-regulated in diabetic nephropathy mouse kidney tissues, high glucose-induced SV40-MES13 cells, and serum of DN patients. It promotes DN-related mesangial cell injury by enhancing apoptosis, inflammation, oxidative stress, and fibrosis through the miR-455-3p/Hmgb1 axis. Its circulating expression may be associated with DN progression."	0.7785
34478012	Inflammation	2022	Exosomes Derived from ADSCs Attenuate Sepsis-Induced Lung Injury by Delivery of Circ-Fryl and Regulation of the miR-490-3p/SIRT3 Pathway.	mmu_circ_0001356	Circ-Fryl	mmu_circ_Fryl	Fryl	sepsis-induced acute lung injury	MONDO:0015796	acute lung injury	unknown	RT-qPCR; RNA-seq	"Circ-Fryl is enriched in ADSC-derived exosomes and contributes to their protective effect against sepsis-induced lung injury. It functions through a circ-Fryl/miR-490-3p/SIRT3 axis to activate SIRT3/AMPK-mediated autophagy, thereby reducing alveolar epithelial cell apoptosis and inflammatory factor expression."	0.6737
34480205	Mammalian genome : official journal of the International Mammalian Genome Society	2021	The circular RNA circCRIM1 inhibits osteosarcoma progression through sponging miR-513.		circCRIM1	hsa_circ_CRIM1	CRIM1	osteosarcoma / OS	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR	"circCRIM1 is down-regulated in osteosarcoma tissues and cell lines, and low expression is associated with advanced FIGO stage, lymph node metastasis, and worse overall survival. Functionally, circCRIM1 acts as a tumor suppressor that inhibits OS cell proliferation, migration, and invasion. Mechanistically, it functions as a ceRNA sponge for miR-513 in the circCRIM1/miR-513 pathway."	0.7078
34516453	Journal of cardiovascular pharmacology	2021	"Circ_0010283/miR-377-3p/Cyclin D1 Axis Is Associated With Proliferation, Apoptosis, Migration, and Inflammation of Oxidized Low-density Lipoprotein-Stimulated Vascular Smooth Muscle Cells."	hsa_circ_0010283	circ_0010283			atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"In this study, circ_0010283 was upregulated in serum from patients with atherosclerosis and in ox-LDL-stimulated human VSMCs. Functionally, circ_0010283 promoted VSMC proliferation, migration, and inflammation while suppressing apoptosis. Mechanistically, it acted through a circ_0010283/miR-377-3p/CCND1 ceRNA axis and was proposed as a potential therapeutic target for AS."	0.6542
34527128	International journal of clinical and experimental pathology	2021	"Circular RNA La-related protein 4 inhibits cell proliferation, migration, and invasion and sponges microRNA-367 in non-small cell lung cancer."		circular RNA (circRNA) La-related protein 4 / circRNA LARP4	hsa_circ_LARP4	LARP4	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"circRNA LARP4 is downregulated in NSCLC cell lines compared with normal lung epithelial cells. Functional assays show that circRNA LARP4 suppresses NSCLC cell proliferation, migration, and invasion while promoting apoptosis. Mechanistically, it directly binds and negatively regulates miR-367, functioning as a miRNA sponge and a potential therapeutic target for NSCLC."	0.6419
34527562	Gland surgery	2021	Upregulated circRAD18 promotes tumor progression by reprogramming glucose metabolism in papillary thyroid cancer.		circRAD18	hsa_circ_RAD18	RAD18	papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circRAD18 is upregulated in papillary thyroid cancer tissues and cell lines. It promotes papillary thyroid cancer cell growth, migration/metastatic behavior, and glucose metabolism reprogramming by sponging miR-516b and enhancing PDK1 expression, suggesting potential therapeutic relevance."	0.8119
34528447	Epigenomics	2021	Hsa_circ_0001021 regulates intestinal epithelial barrier function via sponging miR-224-5p in ulcerative colitis.	hsa_circ_0001021	circ_1021	hsa_circ_AFTPH	AFTPH	ulcerative colitis / UC	MONDO:0005101	ulcerative colitis	down-regulated	RT-qPCR; Microarray	"hsa circ 0001021 is downregulated in inflamed and noninflamed colonic mucosae from patients with UC and is associated with disease severity. It is mainly cytoplasmic in colonic epithelial cells and protects intestinal epithelial barrier function by sponging miR-224-5p to upregulate smad4 and modulate tight junction molecules including ZO-1, occludin and CLDN-2."	0.659
34528678	Journal of biochemistry	2022	Circ_0000514 promotes breast cancer progression by regulating the miR-296-5p/CXCL10 axis.	hsa_circ_0000514	circular RNA 0000514 / circ_0000514			breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circ_0000514 is up-regulated in breast cancer tissues and cell lines. It promotes malignant biological behaviors of breast cancer cells, including proliferation, migration, and invasion, by adsorbing miR-296-5p and increasing CXCL10 expression. Its expression is associated with tumor size and TNM stage, suggesting potential biomarker value."	0.7404
34532100	Journal of gastrointestinal oncology	2021	Candidate oncogene circularNOP10 mediates gastric cancer progression by regulating miR-204/SIRT1 pathway.	hsa_circ_0034351	circularNOP10 / CircNOP10	hsa_circ_NOP10	NOP10	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circNOP10/hsa_circ_0034351 is up-regulated in human gastric cancer tissues and peripheral blood cells, and high expression is associated with tumor stage, metastasis and poor overall survival. Mechanistically, circNOP10 acts as a miR-204 sponge to regulate SIRT1 and activate NF-kappabeta signaling, promoting malignant phenotypes including proliferation, migration, invasion and EMT."	0.8423
34533810	European review for medical and pharmacological sciences	2021	Circ_NCKAP1 promotes skin basal cell carcinoma progression by sponging the miR-148b-5p/HSP90 axis.		Circ_NCKAP1 / hsa_circRNA_002092	hsa_circ_NCKAP1	NCKAP1	skin basal cell carcinoma	MONDO:0005341	skin basal cell carcinoma	up-regulated	RT-qPCR; Microarray	"circ_NCKAP1 is upregulated in skin basal cell carcinoma tissues and TE354.T cells. Functional knockdown experiments indicate that circ_NCKAP1 promotes BCC cell proliferation and suppresses apoptosis. Mechanistically, circ_NCKAP1 acts as a ceRNA for miR-148b-5p, thereby regulating the miR-148b-5p/HSP90 axis and promoting skin BCC progression."	0.7752
34537436	Bone	2022	Circ_0022382 ameliorated intervertebral disc degeneration by regulating TGF-beta3 expression through sponge adsorption of miR-4726-5p.	hsa_circ_0022382	circRNA_0022382 / circFADS2 	hsa_circ_FADS2	FADS2	intervertebral disc degeneration / IDD	MONDO:0011385	intervertebral disk degenerative disorder	down-regulated	RT-qPCR; Microarray	"circ_0022382 is a human FADS2-derived circRNA that is down-regulated in mechanically stimulated degenerative endplate chondrocytes. It alleviates endplate chondrocyte degeneration and IDD by sponging miR-4726-5p to up-regulate TGF-beta3, promoting ECM synthesis and improving chondrocyte phenotype. In vivo injection of circ_0022382 mitigated IDD progression in a rat puncture model."	0.8351
34539988	American journal of translational research	2021	circNFIX facilitates hepatocellular carcinoma progression by targeting miR-3064-5p/HMGA2 to enhance glutaminolysis.	hsa_circ_0049658	circNFIX	hsa_circ_NFIX	NFIX	Hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circNFIX is up-regulated in HCC tissues and cell lines, and high circNFIX expression is associated with poor overall survival. Functionally, circNFIX promotes HCC proliferation, migration, invasion, xenograft tumor growth and glutaminolysis. Mechanistically, circNFIX acts as a ceRNA for miR-3064-5p to enhance HMGA2 expression, supporting the circNFIX/miR-3064-5p/HMGA2 axis as a potential therapeutic target."	0.8314
34539989	American journal of translational research	2021	CircUBXN7 mitigates H/R-induced cell apoptosis and inflammatory response through the miR-622-MCL1 axis.		circular RNA UBXN7 / circUBXN7	hsa_circ_UBXN7	UBXN7	acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	down-regulated	RT-qPCR; Microarray	"CircUBXN7 is down-regulated in AMI and H/R-treated cardiomyocytes. In H9c2 cells, circUBXN7 localizes mainly to the cytoplasm and acts through the miR-622-MCL1 axis to reduce H/R-induced apoptosis and inflammatory cytokine secretion. The study suggests circUBXN7 as a potential therapeutic target for AMI/H/R injury."	0.7731
34539989	American journal of translational research	2021	CircUBXN7 mitigates H/R-induced cell apoptosis and inflammatory response through the miR-622-MCL1 axis.		circular RNA UBXN7 / circUBXN7	rno_circ_UBXN7	UBXN7	acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	down-regulated	RT-qPCR; Microarray	"CircUBXN7 is down-regulated in AMI and H/R-treated cardiomyocytes. In H9c2 cells, circUBXN7 localizes mainly to the cytoplasm and acts through the miR-622-MCL1 axis to reduce H/R-induced apoptosis and inflammatory cytokine secretion. The study suggests circUBXN7 as a potential therapeutic target for AMI/H/R injury."	0.7731
34539989	American journal of translational research	2021	CircUBXN7 mitigates H/R-induced cell apoptosis and inflammatory response through the miR-622-MCL1 axis.		circular RNA UBXN7 / circUBXN7	mmu_circ_UBXN7	UBXN7	acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	down-regulated	RT-qPCR; Microarray	"CircUBXN7 is down-regulated in AMI and H/R-treated cardiomyocytes. In H9c2 cells, circUBXN7 localizes mainly to the cytoplasm and acts through the miR-622-MCL1 axis to reduce H/R-induced apoptosis and inflammatory cytokine secretion. The study suggests circUBXN7 as a potential therapeutic target for AMI/H/R injury."	0.7731
34540004	American journal of translational research	2021	CircRNA LRP6 promotes high-glucose induced proliferation and migration of vascular smooth muscle cells through regulating miR-545-3p/HMGA1 signaling axis.		circRNA LRP6 / circLRP6	hsa_circ_LRP6	LRP6	diabetes	MONDO:0005015	diabetes mellitus	up-regulated	RT-qPCR	"circLRP6 is up-regulated in human VSMCs exposed to high glucose and promotes HG-induced VSMC proliferation, migration, and invasion. Mechanistically, circLRP6 functions as a miR-545-3p sponge to maintain HMGA1 expression, forming a circLRP6/miR-545-3p/HMGA1 axis that may be relevant to diabetic-related cardiovascular disease."	0.6591
34554678	Journal of cardiovascular pharmacology	2021	Knockdown of circ_0004104 Alleviates Oxidized Low-Density Lipoprotein-Induced Vascular Endothelial Cell Injury by Regulating miR-100/TNFAIP8 Axis.	hsa_circ_0004104	circ_0004104			Coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR	"circ_0004104 is up-regulated in the serum of patients with CAD and in ox-LDL-induced human VEC injury models. Functionally, circ_0004104 aggravates endothelial injury by inhibiting proliferation and promoting apoptosis and inflammation. Mechanistically, it sponges miR-100 to positively regulate TNFAIP8, suggesting potential value as a biomarker or therapeutic target for CAD."	0.7045
34562827	"Pathology, research and practice"	2021	CircPTK2 inhibits the tumorigenesis and metastasis of gastric cancer by sponging miR-134-5p and activating CELF2/PTEN signaling.	hsa_circ_0006421	circPTK2	hsa_circ_PTK2	PTK2	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; ISH; Microarray	"hsa_circ_0006421/circPTK2 is down-regulated in gastric cancer and acts as a tumor suppressor. It sponges miR-134-5p in the cytoplasm, activating CELF2/PTEN signaling and reducing PCNA and MMP2 expression, thereby inhibiting GC cell proliferation, invasion, tumor growth and lung metastasis. Low circPTK2 expression is associated with shorter overall survival in GC patients."	0.8658
34563754	"Pathology, research and practice"	2021	circMBOAT2 serves as the sponge of miR-433-3p to promote the progression of bladder cancer.		circMBOAT2	hsa_circ_MBOAT2	MBOAT2	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circMBOAT2 is up-regulated in bladder cancer tissues and cells and is associated with adverse clinicopathological features and poor prognosis. Functionally, circMBOAT2 promotes proliferation and migration of bladder cancer cells. Mechanistically, cytoplasmic circMBOAT2 sponges miR-433-3p to modulate the CREB1 axis, suggesting biomarker and therapeutic-target potential."	0.7785
34565009	Journal of B.U.ON. : official journal of the Balkan Union of Oncology	2021	Circ_0006948 drives the malignant development of bladder cancer via activating the epithelial-mesenchymal transition.	hsa_circ_0006948	circ_0006948			bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"Circ_0006948 is up-regulated in bladder cancer tissues and cell lines, and high expression is associated with advanced tumor stage, metastasis, and poor prognosis. Functionally, circ_0006948 promotes proliferation and migration/metastatic potential of bladder cancer cells. Mechanistically, the study links circ_0006948 to activation of EMT and N-cadherin-associated regulation."	0.5414
34565022	Journal of B.U.ON. : official journal of the Balkan Union of Oncology	2021	A potential diagnostic marker for osteosarcoma: hsa_circ_0005721.	hsa_circ_0005721				osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"hsa_circ_0005721 is up-regulated in osteosarcoma tissues, osteosarcoma cell lines, and patient plasma. High expression is associated with worse overall survival, larger tumors and advanced stage, while knockdown suppresses proliferation in U-2OS and HOS cells. Plasma hsa_circ_0005721 shows diagnostic potential for distinguishing osteosarcoma patients from healthy controls and benign bone tumor patients."	0.6419
34565023	Journal of B.U.ON. : official journal of the Balkan Union of Oncology	2021	"hsa_circ_0005721 triggers proliferation, migration and invasion of osteosarcoma by upregulating the linear transcript TEP1."	hsa_circ_0005721		hsa_circ_TEP1	TEP1	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"hsa_circ_0005721 is up-regulated in osteosarcoma tissues and cell lines. It promotes osteosarcoma cell proliferation, migration and invasion while suppressing apoptosis. Mechanistically, it functions as a ceRNA that binds miR-16-5p to upregulate the linear transcript TEP1."	0.7581
34565758	Endocrine journal	2021	Circ_0079558 promotes papillary thyroid cancer progression by binding to miR-26b-5p to activate MET/AKT signaling.	hsa_circ_0079558	CircRNA_0079558	hsa_circ_RAPGEF5	RAPGEF5	papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circ_0079558 is up-regulated in papillary thyroid carcinoma tissues and cell lines and acts as an oncogenic circRNA. It promotes PTC cell proliferation, migration, invasion and xenograft tumor growth while inhibiting apoptosis, mainly by sponging miR-26b-5p to increase MET expression and activate MET/AKT signaling; a miR-198/FGFR1-related proliferative axis was also implicated."	0.7052
34581623	Cartilage	2021	CircRNA-MSR Regulates LPS-Induced C28/I2 Chondrocyte Injury through miR-643/MAP2K6 Signaling Pathway.	hsa_circ_0005567	circRNA-MSR			Osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"In an LPS-induced in vitro osteoarthritis model using human C28/I2 chondrocytes, circRNA-MSR is up-regulated and contributes to chondrocyte injury. Mechanistically, circRNA-MSR sponges miR-643 to increase MAP2K6 expression, thereby suppressing proliferation and promoting apoptosis, inflammatory cytokine secretion, and ECM degradation. Knockdown of circRNA-MSR alleviates LPS-induced injury and the circRNA-MSR/miR-643/MAP2K6 axis is proposed as a potential diagnostic biomarker or therapeutic target in OA."	0.657
34582975	Cancer letters	2021	Circular RNA circLGMN facilitates glioblastoma progression by targeting miR-127-3p/LGMN axis.	hsa_circ_0033009	circLGMN	hsa_circ_LGMN	LGMN	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR	"circLGMN is an LGMN-derived human circRNA upregulated in high-grade glioma and associated with poor prognosis. It promotes GBM proliferation, invasion, tumorigenesis, and malignancy by sponging miR-127-3p, thereby relieving miR-127-3p-mediated suppression of LGMN mRNA and increasing LGMN protein expression. The study proposes the circLGMN/miR-127-3p/LGMN axis as a potential therapeutic target for GBM."	0.8712
34620741	Anti-cancer drugs	2022	Exosomal circ_0007385 enhances non-small cell lung cancer cell proliferation and stemness via regulating miR-1253/FAM83A axis.	hsa_circ_0007385	circ_0007385	hsa_circ_MEMO1	MEMO1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0007385 is upregulated in NSCLC tissues and cells and is also delivered by NSCLC-derived exosomes. It promotes NSCLC cell proliferation, colony formation, sphere formation, stemness marker expression, and tumor growth by sponging miR-1253 and relieving repression of FAM83A. The study suggests exosomal circ_0007385 may have potential value for NSCLC diagnosis and treatment."	0.7977
34620742	Anti-cancer drugs	2022	The expression of circ_0090049 in hepatocellular carcinoma and the molecular regulation mechanism of other biological functions.	hsa_circ_0090049	Circular RNA_0090049			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0090049 is upregulated in HCC tissues and cell lines and mainly localized in the cytoplasm. It promotes malignant HCC phenotypes, including proliferation, migration, invasion, tumor sphere formation, EMT-associated changes, stemness marker expression, and xenograft tumor growth. Mechanistically, circ_0090049 acts as a sponge for miR-605-5p and miR-548c-3p to increase UBE2T expression, forming circ_0090049/miR-605-5p/UBE2T and circ_0090049/miR-548c-3p/UBE2T regulatory axes."	0.7859
34626691	Cancer letters	2021	Circular RNA circSNX6 promotes sunitinib resistance in renal cell carcinoma through the miR-1184/GPCPD1/ lysophosphatidic acid axis.	hsa_circ_0031607	circSNX6	hsa_circ_SNX6	SNX6	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circSNX6 is upregulated in sunitinib-resistant RCC cells and tumors and promotes sunitinib resistance in vitro and in vivo. Mechanistically, cytoplasmic circSNX6 sponges miR-1184 to upregulate GPCPD1 and increase intracellular LPA levels. High circSNX6 expression is associated with sunitinib resistance and poorer OS/PFS in RCC patients."	0.8993
34637826	"Environmental pollution (Barking, Essex : 1987)"	2022	CircRNA-IGLL1/miR-15a/RNF43 axis mediates ammonia-induced autophagy in broilers jejunum via Wnt/beta-catenin pathway.		CircRNA-IGLL1	gga_circ_IGLL1	IGLL1	ammonia-induced intestinal autophagy	MONDO:0000001	disease	down-regulated	RT-qPCR; RNA-seq	"In ammonia-exposed broiler jejunum, circRNA-IGLL1 is downregulated and participates in excessive autophagy. The study supports a ceRNA mechanism in which circRNA-IGLL1 binds miR-15a to regulate RNF43, thereby modulating Wnt/beta-catenin signaling and ammonia-induced intestinal autophagy."	0.593
34641696	Neoplasma	2021	circRNA_0006470 promotes the proliferation and migration of gastric cancer cells by functioning as a sponge of miR-27b-3p.	hsa_circ_0006470	circRNA_0006470			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"hsa_circ_0006470 is up-regulated in gastric cancer cell lines and acts as an oncogenic circRNA. It sponges miR-27b-3p to regulate ROR1 and PI3KCA, thereby promoting proliferation, migration and invasion while suppressing autophagy in GC cells."	0.6722
34641696	Neoplasma	2021	circRNA_0006470 promotes the proliferation and migration of gastric cancer cells by functioning as a sponge of miR-27b-3p.	hsa_circ_0138960				gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	hsa_circ_0138960 was detected as up-regulated in gastric cancer cell lines by qRT-PCR. The study did not investigate its functional mechanism or clinical significance.	0.1155
34641696	Neoplasma	2021	circRNA_0006470 promotes the proliferation and migration of gastric cancer cells by functioning as a sponge of miR-27b-3p.	hsa_circ_0001895				gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	hsa_circ_0001895 was detected as up-regulated in all four tested gastric cancer cell lines by qRT-PCR. The study did not investigate its functional mechanism or clinical significance.	0.1155
34647573	Journal of biochemistry	2022	A circular RNA derived from FAT atypical cadherin 3 promotes lung cancer progression via forming a regulatory loop with oncogenic ELAV like RNA binding protein 1.	hsa_circ_0096754	FAT atypical cadherin 3 (FAT3) circRNA / circ-FAT3	hsa_circ_FAT3	FAT3	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circ-FAT3 is a human FAT3-derived oncogenic circRNA that is upregulated in lung cancer and associated with larger tumor size, lymph node metastasis, advanced TNM stage, and poorer survival. It promotes lung cancer proliferation, invasion, tumor growth, and metastasis by sponging miR-136-5p to increase HuR expression, while HuR in turn enhances circ-FAT3 biogenesis by binding flanking introns, forming a positive feedback loop."	0.8226
34649241	Cytogenetic and genome research	2021	Circ_ROBO2/miR-149 Axis Promotes the Proliferation and Migration of Human Aortic Smooth Muscle Cells by Activating NF-kappaB Signaling.	hsa_circ_0124644	circ_ROBO2	hsa_circ_ROBO2	ROBO2	coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR	"This study reports that circ_ROBO2/Hsa_circ_0124644 is upregulated in plasma from CAD patients and in PDGF-BB-treated HASMCs. Functionally, circ_ROBO2 promotes HASMC proliferation and migration while suppressing apoptosis. Mechanistically, circ_ROBO2 sponges miR-149 and activates the TRAF6/NF-kappaB signaling pathway, suggesting a role in CAD progression and potential diagnostic relevance."	0.7032
34650680	American journal of translational research	2021	CircRNA_002178 as a ceRNA promotes the development of colorectal cancer by regulating miR-542-3p/CREB1.		circ_002178 / circ_ 0000519	hsa_circ_RPPH1	RPPH1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circ_002178 is up-regulated in colorectal cancer tissues and cell lines and may have diagnostic value based on ROC analysis. Functionally, it promotes CRC cell proliferation, invasion, colony formation, and glycolysis by acting as a ceRNA that sponges miR-542-3p and increases CREB1 expression."	0.8244
34657099	Anti-cancer drugs	2022	Circular RNA circ_0073181 contributes to tumorigenesis by regulating protein tyrosine phosphatase receptor type E via miR-548p in hepatocellular carcinoma.	hsa_circ_0073181	circ_0073181	hsa_circ_RASGRF2	RASGRF2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0073181 is upregulated in HCC tissues and cell lines and is associated with advanced tumor stage. Functional experiments indicate that circ_0073181 promotes HCC proliferation, migration, invasion, angiogenesis, metastasis and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ_0073181 sponges miR-548p to regulate PTPRE expression, and may contribute to HCC progression partly through ERK1/2, JNK and p38 signaling activation."	0.8299
34658354	Nan fang yi ke da xue xue bao = Journal of Southern Medical University	2021	[Correlation of peritumoral circWDR25 expression with the prognosis of patients with hepatocellular carcinoma after curative resection].	hsa_circ_0004310	circWDR25	hsa_circ_WDR25	WDR25	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	ISH; Microarray	"This study identified circWDR25 as the most prominently up-regulated circRNA in exosomes from HCC cell-activated LX-2 hepatic stellate cells. In peritumoral liver tissues from 288 HCC patients, circWDR25 expression correlated positively with alpha-SMA/HSC activation, and high expression was an independent risk factor for poor overall and tumor-free survival after curative resection. The authors suggest that exosome-derived circWDR25 may participate in HSC-HCC crosstalk and could serve as a prognostic and postoperative monitoring indicator."	0.5202
34673127	Cancer letters	2022	Circular RNA circPFKP promotes cell proliferation by activating IMPDH2 in prostate cancer.	hsa_circ_0006608	circPFKP	hsa_circ_PFKP	PFKP	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	"circPFKP is a PFKP-derived circRNA up-regulated in prostate cancer tissues and associated with adverse clinicopathological features. It promotes PCa cell proliferation, migration, invasion, and G1/S cell-cycle progression, at least partly by interacting with IMPDH2 and enhancing the IMPDH2/guanine nucleotide axis. Its biogenesis is promoted by flanking Alu elements and regulated by hnRNPF."	0.8415
34688610	Experimental cell research	2021	HNRNPUL1 inhibits cisplatin sensitivity of esophageal squamous cell carcinoma through regulating the formation of circMAN1A2.		hsa_circMAN1A2_008 / circ-MAN1A2	hsa_circ_MAN1A2	MAN1A2	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	unknown	RT-qPCR	"This study identifies circMAN1A2 as a circRNA involved in cisplatin resistance in ESCC. HNRNPUL1 binds circMAN1A2 and regulates its formation; reduced circMAN1A2 sensitizes ESCC cells to cisplatin, whereas circMAN1A2 overexpression partially restores cisplatin resistance in vitro and in vivo."	0.8246
34694278	Anti-cancer drugs	2022	Circ_0001658 regulates gefitinib resistance of non-small cell lung cancer through miR-409-3p/TWIST1 axis.	hsa_circ_0001658	circ_0001658			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0001658 is up-regulated in NSCLC tissues and gefitinib-resistant NSCLC cells. It promotes NSCLC malignant phenotypes and gefitinib resistance by sponging miR-409-3p and increasing TWIST1 expression; its knockdown reduces gefitinib IC50, suppresses proliferation, and promotes apoptosis."	0.7283
34695896	Zhonghua zhong liu za zhi [Chinese journal of oncology]	2021	[Effect of circBIRC6 targeting miR-367-3p on cisplatin resistance of ovarian cancer cells].		circBIRC6	hsa_circ_BIRC6	BIRC6	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"This study found that circBIRC6 is up-regulated in cisplatin-resistant ovarian cancer SKOV3/DDP cells. Silencing circBIRC6 inhibits proliferation, promotes apoptosis, and reduces cisplatin resistance, likely through up-regulation of miR-367-3p and regulation of Cyclin D1, Bcl-2, p21 and Bax."	0.5554
34702726	Cancer research	2021	Circ0008399 Interaction with WTAP Promotes Assembly and Activity of the m6A Methyltransferase Complex and Promotes Cisplatin Resistance in Bladder Cancer.	hsa_circ_0008399	circ0008399	hsa_circ_RBM3	RBM3	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; RNA-seq	"Circ0008399 is an RBM3-derived human circRNA upregulated in bladder cancer tissues and cell lines and associated with poor overall survival. It localizes mainly to the nucleus, where it binds WTAP to promote WTAP/METTL3/METTL14 m6A methyltransferase complex assembly and stabilizes TNFAIP3 mRNA in an m6A-dependent manner. This circ0008399/WTAP/TNFAIP3 axis suppresses apoptosis and reduces cisplatin sensitivity, making it a potential therapeutic target for overcoming cisplatin resistance in bladder cancer."	0.8838
34704451	Neoplasma	2022	circ_0067934 promotes the progression of papillary thyroid carcinoma cells through miR-1301-3p/HMGB1 axis.	hsa_circ_0067934	circ_0067934	hsa_circ_PRKCI	PRKCI	papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circ_0067934 is upregulated in papillary thyroid carcinoma tissues and cell lines and acts as an oncogenic circRNA. It promotes malignant phenotypes by sponging miR-1301-3p, increasing HMGB1 expression, and activating PI3K/Akt and MAPK signaling. High expression is associated with aggressive clinicopathological features, suggesting potential prognostic and therapeutic relevance."	0.8006
34705617	"Cell cycle (Georgetown, Tex.)"	2021	Hsa_circ_0065217 promotes growth and metastasis of renal cancer through regulating the miR-214-3p-ALPK2 axis.	hsa_circ_0065217	hsa_circRNA_103349	hsa_circ_SCAP	SCAP	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0065217 is up-regulated in RCC tissues and cell lines and is associated with advanced TNM stage, lymph-node metastasis, and larger tumor size. Functionally, it promotes RCC cell proliferation, colony formation, invasion, and metastatic phenotypes. Mechanistically, cytoplasmic hsa_circ_0065217 acts as a ceRNA for miR-214-3p to increase ALPK2 expression, forming a hsa_circ_0065217/miR-214-3p/ALPK2 axis that promotes malignant progression."	0.8625
34707022	The Tohoku journal of experimental medicine	2021	"Circular RNA hsa_circ_0103552 Promotes Proliferation, Migration, and Invasion of Breast Cancer Cells through Upregulating Cysteine-Rich Angiogenic Inducer 61 (CYR61) Expression via Sponging MicroRNA-515-5p."	hsa_circ_0103552	circRNA_0103552			breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"hsa_circ_0103552/circ_0103552 is up-regulated in breast cancer tissues and cell lines and is associated with adverse clinicopathological features and poor overall survival. Functionally, it promotes breast cancer cell proliferation, migration, and invasion. Mechanistically, circ_0103552 acts as a ceRNA for miR-515-5p to increase CYR61 expression."	0.7325
34717918	Experimental cell research	2021	Comprehensive analysis of differentially expressed mRNA and circRNA in Ankylosing spondylitis patients' platelets.	hsa_circ_0000110	circPTPN22	hsa_circ_PTPN22	PTPN22	Ankylosing spondylitis / AS	MONDO:0005306	ankylosing spondylitis	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000110 (circPTPN22) was identified as a down-regulated circRNA shared between platelets and spinal ligament tissues of AS patients and was validated by qRT-PCR. The study predicts that circPTPN22 participates in AS pathogenesis through a circRNA-miRNA-mRNA network involving immune regulation, JAK/STAT and Wnt-related processes, with potential diagnostic or therapeutic relevance."	0.4032
34717918	Experimental cell research	2021	Comprehensive analysis of differentially expressed mRNA and circRNA in Ankylosing spondylitis patients' platelets.	hsa_circ_0005918	circFCHSD2	hsa_circ_FCHSD2	FCHSD2	Ankylosing spondylitis / AS	MONDO:0005306	ankylosing spondylitis	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005918 (circFCHSD2) was identified as a down-regulated circRNA shared between platelets and spinal ligament tissues of AS patients and was validated by qRT-PCR. The study predicts that circFCHSD2 participates in AS pathogenesis through a circRNA-miRNA-mRNA network involving immune regulation, JAK/STAT and Wnt-related processes, with potential diagnostic or therapeutic relevance."	0.4032
34728180	Clinica chimica acta; international journal of clinical chemistry	2021	Circulating circTOLLIP serves as a diagnostic biomarker for liquid biopsy in non-small cell lung cancer.	hsa_circ_0008301	circ_0008301 / circTOLLIP	hsa_circ_TOLLIP	TOLLIP	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"This study identifies circTOLLIP, a TOLLIP-derived circRNA, as significantly down-regulated in NSCLC tissues, cell lines, and patient whole blood. Circulating circTOLLIP shows stability in whole blood and diagnostic value for distinguishing NSCLC from benign lung disease and healthy controls, outperforming several traditional tumor markers. The paper also suggests a possible tumor-suppressive role involving miR-874-3p, proliferation, and apoptosis, although the provided evidence mainly supports biomarker validation."	0.6676
34730059	Autoimmunity	2022	Circ_0114427 promotes LPS-induced septic acute kidney injury by modulating miR-495-3p/TRAF6 through the NF-kappaB pathway.	hsa_circ_0114427	circ_0114427	hsa_circ_ZNF644	ZNF644	septic acute kidney injury	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR	"circ_0114427 is up-regulated in serum from septic AKI patients and in LPS-induced HK-2 cells. It promotes LPS-induced kidney cell injury by sponging miR-495-3p, increasing TRAF6-mediated NF-kappaB/p65 signaling, and enhancing apoptosis and inflammatory responses. Knockdown of circ_0114427 alleviates these injury phenotypes in vitro."	0.8267
34730838	Histology and histopathology	2021	Circ_0000376 downregulation inhibits the progression of non-small cell lung cancer by mediating the miR-488-3p/BRD4 axis and the PI3K/PKB signaling pathway.	hsa_circ_0000376	circ_0000376	hsa_circ_PRH1-PRR4 readthrough		non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0000376 is up-regulated in NSCLC tissues and cell lines and functions as an oncogenic circRNA. Its knockdown suppresses proliferation, colony formation, invasion, migration, cell cycle progression and xenograft tumor growth while promoting apoptosis. Mechanistically, circ_0000376 sponges miR-488-3p to regulate BRD4 and modulates PTEN-mediated PI3K/PKB signaling."	0.7598
34738852	The International journal of biological markers	2021	Circ_0039411 promotes papillary thyroid carcinoma development through mediating the miR-423-5p/SOX4 signaling.	hsa_circ_0039411	circular RNA_0039411	hsa_circ_MMP2		papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"Circ_0039411 is up-regulated in papillary thyroid carcinoma tissues and cell lines. It acts as an oncogenic circRNA that promotes malignant phenotypes and glycolysis while suppressing apoptosis, partly through sponging miR-423-5p to increase SOX4 expression. Knockdown of circ_0039411 also suppresses xenograft tumor growth in vivo."	0.7548
34743403	Liver international : official journal of the International Association for the Study of the Liver	2022	Circular RNA circ_GLIS2 suppresses hepatocellular carcinoma growth and metastasis.	hsa_circ_0005692	circ_GLIS2 / circ_0005692	hsa_circ_GLIS2	GLIS2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"circ_GLIS2 is a human GLIS2-derived circRNA that is down-regulated in HCC tissues and cell lines. Its overexpression suppresses HCC proliferation, migration, invasion, EMT, tumor growth and metastasis while promoting apoptosis, and its low expression is associated with poorer survival. Mechanistically, reduced circ_GLIS2 in HCC is linked to GLIS2 promoter hypermethylation, while EIF4A3 positively regulates circ_GLIS2/GLIS2 expression through binding the GLIS2 transcript."	0.8961
34751973	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2021	"CircPrkcsh, a circular RNA, contributes to the polarization of microglia towards the M1 phenotype induced by spinal cord injury and acts via the JNK/p38 MAPK pathway."		circPrkcsh	mmu_circ_Prkcsh	Prkcsh	spinal cord injury / SCI	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR; ISH	"circPrkcsh is up-regulated in microglia after spinal cord injury. It promotes proinflammatory M1 microglial polarization and neuronal apoptosis by acting as a ceRNA for miR-488, increasing MEKK1 expression and activating the JNK/p38 MAPK pathway. Knockdown of circPrkcsh alleviates inflammation and neuronal apoptosis and improves motor functional recovery in SCI mice."	0.7415
34753774	Cancer research	2022	Oncogenic circRNA C190 Promotes Non-Small Cell Lung Cancer via Modulation of the EGFR/ERK Pathway.	hsa_circ_0000190	C190	hsa_circ_CNIH4	CNIH4	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"hsa_circ_0000190 (C190), a CNIH4-derived human circRNA, is up-regulated in NSCLC tumor tissues and lung cancer cell lines and acts as an oncogenic mediator of EGFR-MAPK-ERK signaling. C190 promotes ERK1/2 activation, cell-cycle and global translation-associated kinase activity, proliferation, migration, survival, and xenograft tumor growth, partly through sponging miR-142-5p to relieve repression of CDK6/CDKs. Its elevated expression is associated with advanced disease and poor clinical outcome, and CRISPR/Cas13a-mediated C190 knockdown suppresses tumor progression."	0.8446
34758237	Clinical laboratory	2021	Regulation Effects of Circular RNA CircPVT1 and miR-125b on NF-kappaB Signal Pathway in Childhood ALL.	hsa_circ_0009143	CircPVT1	hsa_circ_PVT1	PVT1	acute lymphoblastic leukemia / ALL	MONDO:0004967	acute lymphoblastic leukemia	up-regulated	RT-qPCR	"CircPVT1 is up-regulated in childhood ALL bone marrow samples and ALL cell lines. Functionally, it promotes ALL cell proliferation, migration and invasion, at least partly by adsorbing miR-125b and modulating the NF-kappaB signaling pathway. The study proposes circPVT1 as a potential diagnostic and therapeutic target for ALL."	0.6521
34761592	Journal of B.U.ON. : official journal of the Balkan Union of Oncology	2021	Circular RNA PRMT5 knockdown enhances cisplatin sensitivity and immune response in non-small cell lung cancer by regulating miR-138-5p/MYH9 axis.	hsa_circ_0031242	circRNA protein arginine methyltransferase-5 / circ-PRMT5	hsa_circ_PRMT5	PRMT5	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"Circ-PRMT5 is up-regulated in DDP-resistant NSCLC tissues and cells. Its knockdown increases cisplatin sensitivity and T-cell immune response, suppresses malignant phenotypes and tumor growth, and acts mechanistically through the miR-138-5p/MYH9 axis."	0.6542
34762494	Cancer biotherapy & radiopharmaceuticals	2023	Exosome-Mediated Transfer of circ-GLIS3 Enhances Temozolomide Resistance in Glioma Cells Through the miR-548m/MED31 Axis.	hsa_circ_0086248	circ-GLIS3 / circ_0086248	hsa_circ_GLIS3	GLIS3	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; RNA-seq	"circ-GLIS3 is upregulated in TMZ-resistant glioma cells and cell-derived exosomes. It promotes proliferation, invasion, migration, tumor growth and TMZ resistance while suppressing cell cycle arrest and apoptosis, mainly by sponging miR-548m to upregulate MED31 expression."	0.6746
34763405	Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology	2021	[Effect and mechanism of circular RNA BICD2 on the biological behavior of oral squamous cell carcinoma cells].		circRNA BICD2	hsa_circ_BICD2	BICD2	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circ_BICD2 is up-regulated in OSCC tissues and cells and functions as an oncogenic circRNA. Its knockdown suppresses OSCC cell proliferation, migration, invasion, cell-cycle progression, glutamine metabolism and xenograft tumor growth while promoting apoptosis. Mechanistically, circ_BICD2 targets miR_296_5p and regulates TAGLN2 expression through the miR_296_5p/TAGLN2 axis, suggesting potential therapeutic relevance in OSCC."	0.8006
34781178	Biosensors & bioelectronics	2022	Fluorescent paper-based analytical devices for ultra-sensitive dual-type RNA detections and accurate gastric cancer screening.	hsa_circ_0000096	circRNA-HIAT1	hsa_circ_HIAT1		gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"This study used fluorescent paper-based analytical devices to detect circRNA-HIAT1 in plasma for gastric cancer screening. circRNA-HIAT1 was significantly suppressed in GC patient plasma, and its combined detection with miRNA-21 markedly improved diagnostic performance. The paper also describes circRNA-HIAT1 as a GC-related circRNA that can sponge miRNA-21 and suppress ERK signaling based on prior biological context."	0.5261
34784519	"Pathology, research and practice"	2021	Circ_0046600 promotes hepatocellular carcinoma progression via up-regulating SERBP1 through sequestering miR-1258.	hsa_circ_0046600	Circ_0046600	hsa_circ_B3GNTL1	B3GNTL1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0046600 is up-regulated in HCC tissues and cells and acts as a tumor-promoting circRNA. It promotes HCC growth, metastasis and EMT while inhibiting apoptosis through a circ_0046600/miR-1258/SERBP1 ceRNA axis. The study also shows that circ_0046600 can be packaged into exosomes derived from HCC cells."	0.8124
34789642	International heart journal	2021	"Identification of Circ-FNDC3B, an Overexpressed circRNA in Abdominal Aortic Aneurysm, as a Regulator of Vascular Smooth Muscle Cells."	hsa_circ_0006156	circRNA fibronectin type III domain containing 3B / circ-FNDC3B	hsa_circ_FNDC3B	FNDC3B	abdominal aortic aneurysm / AAA	MONDO:0005350	abdominal aortic aneurysm	up-regulated	RT-qPCR	"This study identifies human circ-FNDC3B (hsa_circ_0006156) as an up-regulated circRNA in AAA aorta tissues and Ang-II-treated VSMCs. circ-FNDC3B promotes Ang-II-induced VSMC injury by acting as a ceRNA for miR-143-3p, thereby increasing ADAM10 expression and enhancing apoptosis, inflammation, oxidative stress, and impaired VSMC growth. Its expression also correlates positively with AAA diameter, suggesting potential relevance to AAA development."	0.7795
34790393	Journal of gastrointestinal oncology	2021	Construction of a competing endogenous RNA network related to the prognosis of cholangiocarcinoma and comprehensive analysis of the immunological correlation.	hsa_circ_0002073				cholangiocarcinoma / CCA	MONDO:0019087	cholangiocarcinoma	up-regulated	Microarray	"This bioinformatics study identified hsa_circ_0002073 as an up-regulated circRNA in a CCA prognostic ceRNA subnetwork. The paper proposes that hsa_circ_0002073 may sponge hsa-miR-4524a-3p to regulate SLC16A3, SLC35E4, and DDX4, thereby influencing gene expression regulation, the tumor microenvironment, immune infiltration, and prognosis in CCA."	0.2629
34790400	Journal of gastrointestinal oncology	2021	Hsa_circ_NOTCH3 regulates ZNF146 through sponge adsorption of miR-875-5p to promote tumorigenesis of hepatocellular carcinoma.		circ_NOTCH3	hsa_circ_NOTCH3	NOTCH3	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"This study reports that circ_NOTCH3 is up-regulated in HCC tissues and cell lines and higher in metastatic HCC specimens. Functionally, circ_NOTCH3 promotes HCC cell growth, migration, invasion, tumor growth, and oxaliplatin resistance while suppressing apoptosis. Mechanistically, circ_NOTCH3 acts as a sponge for miR-875-5p to regulate ZNF146, forming a circ_NOTCH3/miR-875-5p/ZNF146 axis."	0.8175
34792792	Journal of physiology and biochemistry	2022	Exosomal transfer of circ_0006174 contributes to the chemoresistance of doxorubicin in colorectal cancer by depending on the miR-1205/CCND2 axis.	hsa_circ_0006174	circ_0006174 / hsa_circRNA_104852			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0006174 is upregulated in DOX-resistant colorectal cancer tissues, cells, and exosomes derived from resistant CRC cells. Exosomal circ_0006174 promotes DOX chemoresistance and malignant cell behaviors by sponging miR-1205 and increasing CCND2 expression, while circ_0006174 knockdown enhances DOX sensitivity in vitro and in xenograft tumors. The study proposes exosomal circ_0006174 as a potential diagnostic biomarker or therapeutic target for DOX resistance in CRC."	0.6521
34814333	Mathematical biosciences and engineering : MBE	2021	Five genes involved in circular RNA-associated competitive endogenous RNA network correlates with metastasis in papillary thyroid carcinoma.	hsa_circ_0004053	circ_0004053			papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	Microarray	"circ_0004053 was identified as an upregulated key circRNA in PTC through microarray-based bioinformatics analysis and external dataset validation. The study predicted that circ_0004053 participates in a ceRNA regulatory network by targeting miRNAs and regulating APOA2 and CCL20, with downstream mRNAs linked to metastatic features in PTC."	0.1768
34814333	Mathematical biosciences and engineering : MBE	2021	Five genes involved in circular RNA-associated competitive endogenous RNA network correlates with metastasis in papillary thyroid carcinoma.	hsa_circ_0028198	circ_0028198			papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	Microarray	"circ_0028198 was identified as an upregulated key circRNA in PTC through microarray-based bioinformatics analysis and external dataset validation. The study predicted that circ_0028198 functions in a ceRNA network by targeting miR-7-5p to regulate APOA2, LPAR5, MFGE8 and TIMP1, with these mRNAs implicated in metastatic features and processes such as EMT, invasion and migration."	0.1768
34825699	Histology and histopathology	2022	Circ-SFMBT2 facilitates the malignant growth of acute myeloid leukemia cells by modulating miR-582-3p/ZBTB20 pathway.	hsa_circ_0017639	circRNA Scm like with four mbt domains 2 / hsa_circRNA_100542	hsa_circ_SFMBT2	SFMBT2	Acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; RNA-seq	"Circ-SFMBT2 is up-regulated in AML patient serum and AML cell lines. Functionally, circ-SFMBT2 promotes AML cell proliferation, migration, invasion and glycolysis while suppressing apoptosis. Mechanistically, it acts as a miR-582-3p sponge to increase ZBTB20 expression, suggesting a potential therapeutic target in AML."	0.7416
34839901	Computers in biology and medicine	2022	"Comprehensive analysis of ceRNA networks to determine genes related to prognosis, overall survival, and immune infiltration in clear cell renal carcinoma."	hsa_circ_0003340	circ_0003340			clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	up-regulated	Microarray	"hsa_circ_0003340 was identified from a human circRNA microarray dataset as an up-regulated differentially expressed circRNA in ccRCC. The study predicted that it participates in a circRNA-miRNA-mRNA ceRNA network linked to cancer-related pathways, survival-associated hub genes, and immune infiltration, but no wet-lab validation was performed."	0.1768
34839901	Computers in biology and medicine	2022	"Comprehensive analysis of ceRNA networks to determine genes related to prognosis, overall survival, and immune infiltration in clear cell renal carcinoma."	hsa_circ_0007836	circ_0007836			clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	up-regulated	Microarray	"hsa_circ_0007836 was identified as an up-regulated differentially expressed circRNA in ccRCC from a GEO human circRNA microarray dataset. It was incorporated into a predicted circRNA-miRNA-mRNA ceRNA network associated with survival-related hub genes and immune infiltration, with evidence limited to bioinformatics analyses."	0.1768
34839901	Computers in biology and medicine	2022	"Comprehensive analysis of ceRNA networks to determine genes related to prognosis, overall survival, and immune infiltration in clear cell renal carcinoma."	hsa_circ_0020303	circ_0020303			clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	up-regulated	Microarray	"hsa_circ_0020303 was identified as an up-regulated differentially expressed circRNA in ccRCC using public microarray data. The article predicted that it may function within a ceRNA axis involving miRNAs and mRNAs enriched in cancer-related and immune-related processes, but the association was not experimentally validated by RT-qPCR."	0.1768
34839901	Computers in biology and medicine	2022	"Comprehensive analysis of ceRNA networks to determine genes related to prognosis, overall survival, and immune infiltration in clear cell renal carcinoma."	hsa_circ_0001873	circ_0001873			clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	up-regulated	Microarray	"hsa_circ_0001873 was identified as an up-regulated differentially expressed circRNA in ccRCC based on GEO microarray analysis. It was included in a predicted ceRNA network linking circRNAs, miRNAs, and mRNAs associated with cancer pathways, overall survival-related hub genes, and immune infiltration; however, the study did not perform experimental validation."	0.1768
34842180	Clinical hemorheology and microcirculation	2022	"Circ-CHFR modulates the proliferation, migration, and invasion of ox-LDL-induced human aorta vascular smooth muscle cells through the miR-214-3p/PAPPA axis."	hsa_circ_0029589	circ-CHFR	hsa_circ_CHFR	CHFR	atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"In this in vitro atherosclerosis model, circ-CHFR is up-regulated in ox-LDL-stimulated HA-VSMCs. circ-CHFR promotes HA-VSMC proliferation, migration, and invasion by sponging miR-214-3p and thereby increasing PAPPA expression. Silencing circ-CHFR suppresses these ox-LDL-induced pathogenic cellular behaviors."	0.6528
34845162	Anti-cancer drugs	2022	Circ_0005033 is an oncogene in laryngeal squamous cell carcinoma and regulates cell progression and Cisplatin sensitivity via miR-107/IGF1R axis.	hsa_circ_0005033	circ_0005033	hsa_circ_HIBADH	HIBADH	laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR	"In this study, hsa_circ_0005033/circ_0005033 was upregulated in LSCC tissues and cells and functioned as an oncogenic circRNA. Its knockdown inhibited LSCC cell viability, proliferation, migration, invasion, xenograft growth and Cisplatin resistance while promoting apoptosis. Mechanistically, circ_0005033 acted through a circ_0005033/miR-107/IGF1R ceRNA axis."	0.8298
34845164	Anti-cancer drugs	2022	CircATXN7 contributes to the progression and doxorubicin resistance of breast cancer via modulating miR-149-5p/HOXA11 pathway.	hsa_circ_0066436	circATXN7 / circ_0066436	hsa_circ_ATXN7	ATXN7	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"CircATXN7 is up-regulated in breast cancer tissues and cells and its high expression is associated with lymph node metastasis, advanced stage, doxorubicin resistance, and poor overall survival. Functionally, circATXN7 promotes proliferation, migration, invasion, tumor growth, and doxorubicin resistance. Mechanistically, circATXN7 sponges miR-149-5p to increase HOXA11 expression, forming a circATXN7/miR-149-5p/HOXA11 axis that drives breast cancer progression and chemoresistance."	0.8146
34847369	"Pathology, research and practice"	2022	Hsa_circ_0007059 sponges miR-421 to repress cell growth and stemness in hepatocellular carcinoma by the PTEN-AKT/mTOR pathway.	hsa_circ_0007059	circ_0007059	hsa_circ_ZNF720	ZNF720	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Northern Blot	"Hsa_circ_0007059/circ_0007059 is downregulated in HCC tissues and cells. It acts as a tumor-suppressive circRNA by sponging miR-421, increasing PTEN expression, and suppressing AKT/mTOR signaling, thereby inhibiting proliferation, migration, invasion and stemness while promoting apoptosis in HCC cells."	0.7893
34850057	The Journal of pharmacy and pharmacology	2022	Circ_UTRN ameliorates caerulein-induced acute pancreatitis in vitro via reducing inflammation and promoting apoptosis through miR-320-3p/PTK2 axis.	mmu_circ_0000144	Circular RNA utrophin (UTRN) / circ_UTRN	mmu_circ_UTRN	UTRN	acute pancreatitis / AP	MONDO:0006515	acute pancreatitis	down-regulated	RT-qPCR	circ_UTRN is down-regulated in caerulein-induced pancreatic acinar cells. Its overexpression ameliorates the in vitro AP phenotype by promoting apoptosis and suppressing inflammatory cytokine release through a miR-320-3p/PTK2 ceRNA-related axis.	0.6376
34850965	Histology and histopathology	2022	"CircAKT3 promotes cell proliferation, survival and glutamine metabolism of gastric cancer by activating SLC1A5 expression via targeting miR-515-5p."	hsa_circ_0000199	circ_0000199 / circAKT3	hsa_circ_AKT3	AKT3	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circAKT3 is up-regulated in gastric cancer tissues and cell lines. It functions as an oncogenic circRNA by sponging miR-515-5p to increase SLC1A5 expression, thereby promoting proliferation, survival, glutamine metabolism and tumor growth. Knockdown of circAKT3 suppresses malignant phenotypes and may represent a potential therapeutic strategy."	0.8298
34863886	Cancer letters	2022	Hypoxia-induced ebv-circLMP2A promotes angiogenesis in EBV-associated gastric carcinoma through the KHSRP/VHL/HIF1alpha/VEGFA pathway.		EBV-encoded circular RNA LMP2A / ebv-circLMP2A	EBV_circ_LMP2A	LMP2A	EBV-associated gastric carcinoma / EBVaGC	MONDO:0017784	Epstein-Barr virus-associated gastric carcinoma	up-regulated	RT-qPCR	"ebv-circLMP2A is a hypoxia-induced EBV-encoded circRNA implicated in EBV-associated gastric carcinoma angiogenesis. It binds KHSRP to promote VHL mRNA decay, stabilizing HIF1alpha and activating VEGFA-mediated angiogenic signaling, while HIF1alpha further upregulates ebv-circLMP2A to form a positive feedback loop. Clinically, high ebv-circLMP2A expression correlates with MVD, HIF1alpha, VEGFA, distant metastasis and poor prognosis, supporting its potential as a therapeutic target."	0.798
34875309	International journal of biological macromolecules	2022	Bombyx mori Akirin hijacks a viral peptide vSP27 encoded by BmCPV circRNA and activates the ROS-NF-kappaB pathway against viral infection.		circRNA-vSP27			Bombyx mori cypovirus infection / BmCPV infection	MONDO:0005108	viral infectious disease	up-regulated	RT-qPCR	"circRNA-vSP27 is a BmCPV-derived viral circRNA that encodes the small peptide vSP27. Through vSP27, it induces ROS generation and activates Akirin-dependent NF-kappaB signaling, increasing antimicrobial peptide expression and suppressing BmCPV infection."	0.74
34875312	Gastroenterologia y hepatologia	2022	CircRNA-001241 mediates sorafenib resistance of hepatocellular carcinoma cells by sponging miR-21-5p and regulating TIMP3 expression.	hsa_circ_0000508	circ-001241			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circRNA-001241 is up-regulated in HCC tissues and sorafenib-resistant HCC cells and is associated with poor prognosis. It promotes proliferation, metastasis, and sorafenib resistance while suppressing apoptosis, mainly by acting as a ceRNA for miR-21-5p to increase TIMP3 expression. Knockdown of circRNA-001241 enhances sorafenib sensitivity in vitro and in a cell line-derived xenograft model."	0.8595
34879367	Acta haematologica	2022	Using Circ-ANAPC7 as a Novel Type of Biomarker in the Monitoring of Acute Myeloid Leukemia.	hsa_circ_0005785	circ-anaphase promoting complex subunit 7 (ANAPC7)	hsa_circ_ANAPC7	ANAPC7	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"This study validated that circ-ANAPC7 is up-regulated in AML bone marrow samples by RT-qPCR. Its expression has auxiliary diagnostic value, correlates with WBC count and bone marrow blast percentage, and changes with disease status, supporting its potential use for AML diagnosis and monitoring recurrence. The study did not establish a molecular mechanism or a prognostic survival association."	0.4758
34882112	Journal of cardiovascular pharmacology	2021	Knockdown of Circular Ubiquitin-specific Peptidase 9 X-Linked Alleviates Oxidized Low-density Lipoprotein-induced Injuries of Human Umbilical Vein Endothelial Cells by Mediating the miR-148b-3p/KLF5 Signaling Pathway.	hsa_circ_0003575	circular ubiquitin-specific peptidase 9 X-linked / circUSP9X	hsa_circ_USP9X	USP9X	atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"This study shows that circUSP9X is up-regulated in ox-LDL-treated HUVEC atherosclerosis cell models. circUSP9X knockdown protects against endothelial cell injury by reducing apoptosis, inflammation, oxidative stress, and LDH leakage, partly through the circUSP9X/miR-148b-3p/KLF5 regulatory axis."	0.7615
34893100	Zhongguo shi yan xue ye xue za zhi	2021	[Analysis of the Differential Expression of circRNA in Acute Myeloid Leukemia by GEO Database].	hsa_circ_0001080				acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	Microarray	hsa_circ_0001080 was identified as an up-regulated circRNA in AML bioinformatics analysis. The study predicted that it may act through a ceRNA-related mechanism involving hsa-miR-150-5p and hsa-miR-188-5p to affect mRNA expression.	0.1768
34893100	Zhongguo shi yan xue ye xue za zhi	2021	[Analysis of the Differential Expression of circRNA in Acute Myeloid Leukemia by GEO Database].	hsa_circ_0004511				acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	dysregulated	Microarray	"hsa_circ_0004511 was identified in the AML microarray-based bioinformatics analysis. The paper predicted that it may positively regulate gene expression in AML through a circRNA-miRNA-mRNA regulatory network, but did not provide experimental validation or specific partners in the supplied text."	0.1768
34893100	Zhongguo shi yan xue ye xue za zhi	2021	[Analysis of the Differential Expression of circRNA in Acute Myeloid Leukemia by GEO Database].	hsa_circ_0054211				acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	dysregulated	Microarray	"hsa_circ_0054211 was identified in the AML microarray-based bioinformatics analysis. The paper predicted that it may positively regulate gene expression in AML through a circRNA-miRNA-mRNA regulatory network, but did not provide experimental validation or specific partners in the supplied text."	0.1768
34893100	Zhongguo shi yan xue ye xue za zhi	2021	[Analysis of the Differential Expression of circRNA in Acute Myeloid Leukemia by GEO Database].	hsa_circ_0001944				acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	dysregulated	Microarray	"hsa_circ_0001944 was identified in the AML microarray-based bioinformatics analysis. The paper predicted that it may positively regulate gene expression in AML through a circRNA-miRNA-mRNA regulatory network, but did not provide experimental validation or specific partners in the supplied text."	0.1768
34893100	Zhongguo shi yan xue ye xue za zhi	2021	[Analysis of the Differential Expression of circRNA in Acute Myeloid Leukemia by GEO Database].	hsa_circ_0004126				acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	down-regulated	Microarray	"hsa_circ_0004126 was identified as part of the down-regulated ceRNA network in AML. The study predicted axes involving hsa-miR-17-5p or hsa-miR-125a-3p with THBS1 and hsa-miR-125a-5p with CCL5, linking it to TGF-beta, Rap1, and cytokine-cytokine receptor interaction pathways."	0.1768
34893100	Zhongguo shi yan xue ye xue za zhi	2021	[Analysis of the Differential Expression of circRNA in Acute Myeloid Leukemia by GEO Database].	hsa_circ_0000227				acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	down-regulated	Microarray	"hsa_circ_0000227 was identified as part of the down-regulated ceRNA network in AML. The predicted axes connect it with hsa-miR-342-3p/TFRC and hsa-miR-20a-5p/CCL5, involving hematopoietic cell lineage and NOD-like receptor signaling pathway annotations."	0.1768
34894921	Autoimmunity	2022	CircVMA21 ameliorates lipopolysaccharide (LPS)-induced HK-2 cell injury depending on the regulation of miR-7-5p/PPARA.		circRNA vacuolar ATPase assembly factor VMA21 (circVMA21) / circVMA21	hsa_circ_VMA21	VMA21	sepsis-induced acute kidney injury	MONDO:0002492	acute kidney injury	down-regulated	RT-qPCR	"CircVMA21 is down-regulated in serum from septic AKI patients and in LPS-stimulated HK2 cells. Its overexpression protects HK2 cells from LPS-induced injury by improving cell viability and suppressing apoptosis, inflammation and oxidative stress. Mechanistically, circVMA21 sponges miR-7-5p and thereby positively regulates PPARA expression."	0.7785
34896110	European journal of pharmacology	2022	Tanshinone IIA sodium sulfonate attenuates inflammation by upregulating circ-Sirt1 and inhibiting the entry of NF-kappaB into the nucleus.		Circ-sirt1 / circ-0093887	rno_circ_Sirt1	Sirt1	inflammation	MONDO:0005046	immune system disorder	down-regulated	RT-qPCR; ISH	"circ-Sirt1 is reduced in LPS-induced inflammatory models and restored by TSS treatment. The study suggests that circ-Sirt1 suppresses inflammation by binding NF-kappaB P65 and inhibiting its nuclear translocation, thereby reducing inflammatory cytokine responses."	0.5997
34896110	European journal of pharmacology	2022	Tanshinone IIA sodium sulfonate attenuates inflammation by upregulating circ-Sirt1 and inhibiting the entry of NF-kappaB into the nucleus.		Circ-sirt1 / circ-0093887	mmu_circ_Sirt1	Sirt1	inflammation	MONDO:0005046	immune system disorder	down-regulated	RT-qPCR; ISH	"circ-Sirt1 is reduced in LPS-induced inflammatory models and restored by TSS treatment. The study suggests that circ-Sirt1 suppresses inflammation by binding NF-kappaB P65 and inhibiting its nuclear translocation, thereby reducing inflammatory cytokine responses."	0.5997
34906917	"Pathology, research and practice"	2022	Circ_0007919 exerts an anti-tumor role in colorectal cancer through targeting miR-942-5p/TET1 axis.	hsa_circ_0007919	circ_0007919	hsa_circ_ABR	ABR	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	"circ_0007919 is down-regulated in colorectal cancer tissues and cell lines, and its low expression is associated with shorter overall survival. Functionally, circ_0007919 suppresses CRC cell proliferation and migration by acting as a cytoplasmic ceRNA for miR-942-5p, thereby increasing TET1 expression and contributing to tumor-suppressive epigenetic regulation."	0.7486
34907911	The Journal of clinical investigation	2021	Circular RNA circEsyt2 regulates vascular smooth muscle cell remodeling via splicing regulation.		circEsyt2	hsa_circ_ESYT2	Esyt2	cardiovascular diseases	MONDO:0004995	cardiovascular disorder	up-regulated	RT-qPCR; ISH; RNA-seq	"circEsyt2 is upregulated in atherosclerotic and injured vessels and in severe CAD arteries, and it promotes VSMC remodeling by enhancing proliferation and migration while suppressing apoptosis and differentiation. Mechanistically, circEsyt2 binds PCBP1 in the cytoplasm, limits PCBP1 nuclear translocation, suppresses PCBP1/U2AF65-dependent p53beta splicing, and thereby alters p53 target genes that control VSMC proliferation and apoptosis."	0.8469
34907911	The Journal of clinical investigation	2021	Circular RNA circEsyt2 regulates vascular smooth muscle cell remodeling via splicing regulation.		circEsyt2	mmu_circ_Esyt2	Esyt2	cardiovascular diseases	MONDO:0004995	cardiovascular disorder	up-regulated	RT-qPCR; ISH; RNA-seq	"circEsyt2 is upregulated in atherosclerotic and injured vessels and in severe CAD arteries, and it promotes VSMC remodeling by enhancing proliferation and migration while suppressing apoptosis and differentiation. Mechanistically, circEsyt2 binds PCBP1 in the cytoplasm, limits PCBP1 nuclear translocation, suppresses PCBP1/U2AF65-dependent p53beta splicing, and thereby alters p53 target genes that control VSMC proliferation and apoptosis."	0.8469
34911837	Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences	2021	Differential expression of circular RNA in patients with white matter hyperintensity and cognitive impairment.	hsa_circ_0092222		hsa_circ_RPS4Y1	RPS4Y1	white matter hyperintensity	MONDO:0013680	cognitive impairment with or without cerebellar ataxia	up-regulated	Microarray	"hsa_circ_0092222 was up-regulated in PBMCs from patients with WMH with or without cognitive impairment compared with controls. The study predicted that it may act as a ceRNA for hsa-miR-19a-3p/hsa-miR-19b-3p, regulate RPS4Y1, and contribute to white matter damage through the JAK2/STAT3 pathway."	0.348
34911837	Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences	2021	Differential expression of circular RNA in patients with white matter hyperintensity and cognitive impairment.	hsa_circ_0000662		hsa_circ_AXIN1	AXIN1	white matter hyperintensity	MONDO:0013680	cognitive impairment with or without cerebellar ataxia	down-regulated	Microarray	hsa_circ_0000662 was down-regulated in PBMCs from patients with WMH with or without cognitive impairment compared with controls. The study predicted that it may regulate the hsa-miR-194/AXIN1 axis and contribute to white matter injury through Wnt signaling.	0.348
34911837	Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences	2021	Differential expression of circular RNA in patients with white matter hyperintensity and cognitive impairment.	hsa_circ_0083773		hsa_circ_SCARA3	SCARA3	white matter hyperintensity	MONDO:0013680	cognitive impairment with or without cerebellar ataxia	down-regulated	Microarray	"hsa_circ_0083773 was down-regulated in PBMCs from patients with WMH with or without cognitive impairment compared with controls. The study predicted seven interacting miRNAs and proposed that hsa_circ_0083773 may regulate SCARA3 through hsa-let-7b-5p, contributing to white matter injury and cognitive impairment."	0.348
34913223	The journal of gene medicine	2022	Circular RNA circ_0040823 inhibits the proliferation of acute myeloid leukemia cells and induces apoptosis by regulating miR-516b/PTEN.	hsa_circ_0040823	circRNA 0040823			acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	down-regulated	RT-qPCR; Microarray	"circ_0040823 is downregulated in AML patients and leukemia cell lines. It acts as a tumor-suppressive circRNA by sponging miR-516b and relieving repression of PTEN, thereby inhibiting leukemia cell proliferation, promoting apoptosis and cell cycle arrest, and suppressing xenograft tumor growth. Higher circ_0040823 expression is associated with better overall and disease-free survival in AML patients."	0.8399
34913472	Histology and histopathology	2022	Circular RNA circFADS2 inhibits the progression of cutaneous squamous cell carcinoma by regulating miR-766-3p/HOXA9 axis.	hsa_circ_0022392	circRNA fatty acid desaturase 2 (circFADS2) / CircFADS2	hsa_circ_FADS2		cutaneous squamous cell carcinoma / CSCC	MONDO:0002529	skin squamous cell carcinoma	down-regulated	RT-qPCR; Microarray	"CircFADS2 is downregulated in CSCC tissues and cell lines and appears to function as a tumor suppressor. Mechanistically, cytoplasmic circFADS2 sponges miR-766-3p to promote HOXA9 expression, thereby inhibiting CSCC cell proliferation, migration, invasion, glycolysis, and xenograft tumor growth. Clinically, lower circFADS2 expression is associated with lymph node metastasis and poorer survival."	0.8571
34914211	Zhonghua nan ke xue = National journal of andrology	2021	[Hsa_circ_0005221 promotes prostate cancer progression through the miR-339-5p/STAT5a pathway].	hsa_circ_0005221		hsa_circ_NPLOC4	NPLOC4	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"hsa_circ_0005221 is up-regulated in prostate cancer tissues and cells. It promotes malignant prostate cancer phenotypes including proliferation, migration, invasion and EMT while suppressing apoptosis, likely by functioning as a cytoplasmic miR-339-5p sponge and regulating the STAT5A/STAT5a pathway."	0.8119
34915498	International archives of allergy and immunology	2022	CircRNAPTK2 Promotes Cardiomyocyte Apoptosis in Septic Mice by Competitively Binding to miR-29b-3p with BAK1.		CircRNAPTK2 / CircRNA protein tyrosine kinase 2 (circPTK2)	mmu_circ_PTK2	PTK2	sepsis-induced myocardial injury	MONDO:0004994	cardiomyopathy	up-regulated	RT-qPCR	"CircPTK2 is up-regulated in the myocardium of CLP-induced septic mice. It promotes myocardial damage, inflammatory responses, and cardiomyocyte apoptosis through a cytoplasmic ceRNA mechanism involving miR-29b-3p and BAK1 mRNA. Silencing circPTK2 protects cardiac function in septic mice, and this protection is reversed by miR-29b-3p inhibition or BAK1 overexpression."	0.7204
34916222	Cancer research	2022	Activation of YAP1 by N6-Methyladenosine-Modified circCPSF6 Drives Malignancy in Hepatocellular Carcinoma.	hsa_circ_0000417	circCPSF6 / circular cleavage and polyadenylation specific factor 6	hsa_circ_CPSF6	CPSF6	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH	"circCPSF6 is an upregulated m6A-modified circRNA in HCC and high expression predicts worse survival. It promotes HCC proliferation, tumor growth, migration, invasion, EMT and metastasis by binding PCBP2, reducing PCBP2 interaction with YAP1 mRNA, stabilizing YAP1 and activating YAP1 downstream signaling. ALKBH5/YTHDF2-mediated m6A regulation controls circCPSF6 stability."	0.9026
34924499	Anti-cancer drugs	2022	CircCDK1 knockdown reduces CDK1 expression by targeting miR-489-3p to suppress the development of breast cancer and strengthen the sensitivity of Tamoxifen.	hsa_circ_0093827	circCDK1 / circRNA-cyclin dependent kinase 1	hsa_circ_CDK1	CDK1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"CircCDK1 is up-regulated in Tamoxifen-resistant breast cancer tissues and cells. It promotes Tamoxifen resistance, proliferation and survival by sponging miR-489-3p to increase CDK1 expression, while circCDK1 knockdown enhances Tamoxifen sensitivity and suppresses tumor growth in vitro and in vivo."	0.8571
34931691	Histology and histopathology	2022	Knockdown of circular RNA hsa_circ_0062270 suppresses the progression of melanoma via downregulation of CDC45.	hsa_circ_0062270		hsa_circ_CDC45	CDC45	melanoma	MONDO:0005105	melanoma	up-regulated	RT-qPCR	"hsa_circ_0062270 is up-regulated in melanoma cells and acts as a pro-tumorigenic circRNA. Its knockdown suppresses melanoma cell viability, proliferation, invasion and xenograft tumor growth while promoting apoptosis, partly through interaction with EIF4A3 and downregulation of CDC45/mRNA stability."	0.6742
34933019	The Journal of investigative dermatology	2022	CircARHGAP12 Triggers Mesenchymal Stromal Cell Autophagy to Facilitate its Effect on Repairing Diabetic Wounds by Sponging miR-301b-3p/ATG16L1 and miR-301b-3p/ULK2.	hsa_circ_0018103	circARHGAP12	hsa_circ_ARHGAP12	ARHGAP12	diabetic wound	MONDO:0005015	diabetes mellitus	down-regulated	RT-qPCR; RNA-seq	"circARHGAP12 is downregulated in human MSCs under high-glucose conditions relevant to diabetic wounds. It functions as a cytoplasmic ceRNA that sponges miR-301b-3p, increases ATG16L1 and ULK2 expression, enhances autophagy, reduces MSC apoptosis, and improves MSC-mediated repair of diabetic wounds in vivo."	0.8131
34933708	"Cellular and molecular biology (Noisy-le-Grand, France)"	2021	Analysis of circRNA regulatory network in myocardial tissue of type 1 diabetic mice.	mmu_circ_0001560				type 1 diabetes mellitus	MONDO:0005147	type 1 diabetes mellitus	down-regulated	RT-qPCR	"This circRNA was reported as significantly down-regulated in myocardial tissue from a streptozotocin-induced type 1 diabetic mouse model. The study did not investigate its downstream targets or mechanism, but placed it within an aberrant circRNA regulatory network associated with diabetic cardiomyopathy."	0.2586
34933708	"Cellular and molecular biology (Noisy-le-Grand, France)"	2021	Analysis of circRNA regulatory network in myocardial tissue of type 1 diabetic mice.	mmu_circ_0001800				type 1 diabetes mellitus	MONDO:0005147	type 1 diabetes mellitus	down-regulated	RT-qPCR	"This circRNA was reported as significantly down-regulated in myocardial tissue from a streptozotocin-induced type 1 diabetic mouse model. The study did not investigate its downstream targets or mechanism, but placed it within an aberrant circRNA regulatory network associated with diabetic cardiomyopathy."	0.2586
34933708	"Cellular and molecular biology (Noisy-le-Grand, France)"	2021	Analysis of circRNA regulatory network in myocardial tissue of type 1 diabetic mice.	mmu_circ_0001801				type 1 diabetes mellitus	MONDO:0005147	type 1 diabetes mellitus	down-regulated	RT-qPCR	"This circRNA was reported as significantly down-regulated in myocardial tissue from a streptozotocin-induced type 1 diabetic mouse model. The study did not investigate its downstream targets or mechanism, but placed it within an aberrant circRNA regulatory network associated with diabetic cardiomyopathy."	0.2586
34933708	"Cellular and molecular biology (Noisy-le-Grand, France)"	2021	Analysis of circRNA regulatory network in myocardial tissue of type 1 diabetic mice.	mmu_circ_0002281				type 1 diabetes mellitus	MONDO:0005147	type 1 diabetes mellitus	down-regulated	RT-qPCR	"This circRNA was reported as significantly down-regulated in myocardial tissue from a streptozotocin-induced type 1 diabetic mouse model. The study did not investigate its downstream targets or mechanism, but placed it within an aberrant circRNA regulatory network associated with diabetic cardiomyopathy."	0.2586
34933708	"Cellular and molecular biology (Noisy-le-Grand, France)"	2021	Analysis of circRNA regulatory network in myocardial tissue of type 1 diabetic mice.	mmu_circ_0000614				type 1 diabetes mellitus	MONDO:0005147	type 1 diabetes mellitus	down-regulated	RT-qPCR	"This circRNA was reported as significantly down-regulated in myocardial tissue from a streptozotocin-induced type 1 diabetic mouse model. The study did not investigate its downstream targets or mechanism, but placed it within an aberrant circRNA regulatory network associated with diabetic cardiomyopathy."	0.2586
34936289	Critical reviews in eukaryotic gene expression	2021	CircRNA circSEPT9 Downregulates miR-10a through Methylation to Promote Cell Proliferation in Laryngeal Squamous Cell Carcinoma.		circSEPT9	hsa_circ_SEPT9	SEPT9	laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR	circSEPT9 is up-regulated in LSCC tissues and functions as an oncogenic circRNA in this study. It promotes UM-SCC-17A cell proliferation by increasing methylation of the miR-10a gene and reducing miR-10a expression.	0.5812
34936300	"Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer"	2021	Potential of Curcumin and Quercetin in Modulation of Premature Mitochondrial Senescence and Related Changes during Lung Carcinogenesis.		circFOXP1	hsa_circ_FOXP1	Foxp1	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circFOXP1 is up-regulated in lung cancer tissues and high expression is associated with poor overall survival. Functionally, circFOXP1 promotes lung cancer cell proliferation, migration, invasion, EMT and xenograft tumor growth while inhibiting ferroptosis. Mechanistically, it sponges miR-520a-5p to increase SLC7A11 expression, supporting malignant progression and suggesting potential diagnostic and therapeutic relevance."	0.8769
34953789	The Journal of allergy and clinical immunology	2022	Hsa_circ_0004287 inhibits macrophage-mediated inflammation in an N6-methyladenosine-dependent manner in atopic dermatitis and psoriasis.	hsa_circ_0004287	circ4287	hsa_circ_MALAT1		Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR; Microarray	"hsa_circ_0004287 is up-regulated in PBMCs of both atopic dermatitis and psoriasis patients and is mainly expressed by macrophages under inflammatory conditions. Functionally, it suppresses M1 macrophage activation and alleviates AD-like and psoriasis-like skin inflammation. Mechanistically, it competitively binds IGF2BP3 to reduce MALAT1 stability in an m6A-dependent manner, promoting S100A8/S100A9 ubiquitination degradation and suppressing p38/MAPK-driven inflammatory activation."	0.8825
34953789	The Journal of allergy and clinical immunology	2022	Hsa_circ_0004287 inhibits macrophage-mediated inflammation in an N6-methyladenosine-dependent manner in atopic dermatitis and psoriasis.	hsa_circ_0004287	circ4287	hsa_circ_MALAT1		psoriasis	MONDO:0005083	psoriasis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0004287 is up-regulated in PBMCs of both atopic dermatitis and psoriasis patients and is mainly expressed by macrophages under inflammatory conditions. Functionally, it suppresses M1 macrophage activation and alleviates AD-like and psoriasis-like skin inflammation. Mechanistically, it competitively binds IGF2BP3 to reduce MALAT1 stability in an m6A-dependent manner, promoting S100A8/S100A9 ubiquitination degradation and suppressing p38/MAPK-driven inflammatory activation."	0.8825
34954748	Journal of cardiovascular pharmacology	2022	Circular RNA circ_0002984 Promotes Cell Proliferation and Migration by Regulating miR-181b-5p/Vascular Endothelial Growth Factor Axis and PI3K-AKT Signaling Pathway in Oxidized Low-Density Lipoprotein-Treated Vascular Smooth Muscle Cells.	hsa_circ_0002984	circ_0002984	hsa_circ_ARHGAP32	ARHGAP32	atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"circ_0002984 is upregulated in serum from AS patients and in ox-LDL-stimulated VSMCs. It promotes VSMC proliferation and migration by sponging miR-181b-5p, thereby regulating VEGFA and activating the PI3K-AKT signaling pathway. Knockdown of circ_0002984 suppresses these AS-related cellular phenotypes, suggesting potential therapeutic relevance."	0.8115
34965937	Cancer research	2022	EIF4A3-Induced circARHGAP29 Promotes Aerobic Glycolysis in Docetaxel-Resistant Prostate Cancer through IGF2BP2/c-Myc/LDHA Signaling.	hsa_circ_0003310	circARHGAP29	hsa_circ_ARHGAP29	ARHGAP29	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; RNA-seq	"circARHGAP29 is an ARHGAP29-derived human circRNA that is upregulated in prostate cancer, especially docetaxel-resistant PCa cells and clinical samples. EIF4A3 promotes its biogenesis and cytoplasmic export, while circARHGAP29 enhances docetaxel resistance and aerobic glycolysis by interacting with IGF2BP2, stabilizing LDHA mRNA, and stabilizing c-Myc mRNA/protein to increase LDHA transcription. Clinically, elevated circARHGAP29 is associated with higher Gleason grade, advanced tumor stage, and poorer response to docetaxel therapy."	0.886
34974134	Brain research bulletin	2022	CircPOSTN competes with KIF1B for miR-185-5p binding sites to promote the tumorigenesis of glioma.	hsa_circ_0030018	CircRNA periostin / circPOSTN	hsa_circ_POSTN	POSTN	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"CircPOSTN is up-regulated in glioma tissues and cell lines and functions as an oncogenic circRNA. It promotes glioma proliferation, cell cycle progression, migration, invasion and xenograft growth while suppressing apoptosis. Mechanistically, circPOSTN acts as a ceRNA for miR-185-5p to relieve repression of KIF1B, forming the circPOSTN/miR-185-5p/KIF1B regulatory axis."	0.8175
34974242	"Pathology, research and practice"	2022	CircRTN4IP1 regulates the malignant progression of intrahepatic cholangiocarcinoma by sponging miR-541-5p to induce HIF1A production.	hsa_circ_0008514	circRNA reticulon 4 interacting protein 1 / circ_104168	hsa_circ_RTN4IP1	RTN4IP1	intrahepatic cholangiocarcinoma / ICC	MONDO:0003210	intrahepatic cholangiocarcinoma	up-regulated	RT-qPCR	"circRTN4IP1 is up-regulated in ICC tissues and cell lines and functions as an oncogenic circRNA. It promotes ICC cell proliferation, cell cycle progression, glycolytic glucose metabolism and xenograft tumor growth while suppressing apoptosis. Mechanistically, circRTN4IP1 sponges miR-541-5p to increase HIF1A expression, suggesting the circRTN4IP1/miR-541-5p/HIF1A axis as a potential therapeutic target in ICC."	0.8568
34978042	"Reproductive sciences (Thousand Oaks, Calif.)"	2022	"CircPAPPA Regulates the Proliferation, Migration, Invasion, Apoptosis, and Cell Cycle of Trophoblast Cells Through the miR-3127-5p/HOXA7 Axis."	hsa_circ_0088227	circRNA pregnancy-associated plasma protein A (circPAPPA) / circPAPPA	hsa_circ_PAPPA	PAPPA	preeclampsia / PE	MONDO:0005081	preeclampsia	down-regulated	RT-qPCR	"CircPAPPA is down-regulated in placental tissues from PE patients and is mainly cytoplasmic in trophoblast cells. It promotes trophoblast proliferation, migration, invasion and cell cycle progression while suppressing apoptosis through the miR-3127-5p/HOXA7 ceRNA axis, suggesting biomarker and therapeutic-target potential for PE."	0.8278
34979511	Gerontology	2022	Circular RNA CCDC66 Regulates Osteoarthritis Progression by Targeting miR-3622b-5p.	hsa_circ_0001313	CircCCDC66	hsa_circ_CCDC66	CCDC66	osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"CircCCDC66 is up-regulated in osteoarthritis cartilage tissues. In chondrocytes, circCCDC66 suppresses proliferation, promotes apoptosis and inflammation, and functions mechanistically through the miR-3622b-5p/SIRT3 axis, suggesting therapeutic relevance in OA."	0.6521
34981843	Drug development research	2022	CircRNF121 knockdown suppresses the progression of cervical cancer by regulating miR-153-3p/ATF2 axis and wnt/beta-catenin pathway.	hsa_circ_0023404	circRNA ring finger protein 121 / circRNF121	hsa_circ_RNF121	RNF121	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circRNF121 is up-regulated in cervical cancer tissues and cell lines and is mainly localized in the cytoplasm. It promotes malignant progression by sponging miR-153-3p, increasing ATF2 expression, and activating the Wnt/beta-catenin pathway, thereby enhancing proliferation, migration, invasion, EMT, autophagy, and tumor growth. Its expression is associated with tumor size, TNM stage, and distant metastasis, suggesting potential therapeutic relevance."	0.8267
34999209	Molecular therapy : the journal of the American Society of Gene Therapy	2022	Targeting circular RNA-MET for anti-angiogenesis treatment via inhibiting endothelial tip cell specialization.	hsa_circ_0082002	circMET	hsa_circ_MET	MET	ocular vascular dysfunction	MONDO:0019056	neuromuscular disease	up-regulated	RT-qPCR	"circMET is upregulated in mouse models of ocular pathological angiogenesis and in vitreous samples from patients with diabetic retinal vascular disease. It promotes endothelial tip cell specialization, endothelial sprouting, migration, and pathological angiogenesis by forming an m6A-dependent circMET/IGF2BP2/NRARP or ESM1 complex that stabilizes NRARP and ESM1 expression. The study proposes circMET as a biomarker and therapeutic target for proliferative retinopathies and other neovascular diseases."	0.7519
34999209	Molecular therapy : the journal of the American Society of Gene Therapy	2022	Targeting circular RNA-MET for anti-angiogenesis treatment via inhibiting endothelial tip cell specialization.	mmu_circ_0013214	circMET	mmu_circ_MET	MET	ocular vascular dysfunction	MONDO:0019056	neuromuscular disease	up-regulated	RT-qPCR	"circMET is upregulated in mouse models of ocular pathological angiogenesis and in vitreous samples from patients with diabetic retinal vascular disease. It promotes endothelial tip cell specialization, endothelial sprouting, migration, and pathological angiogenesis by forming an m6A-dependent circMET/IGF2BP2/NRARP or ESM1 complex that stabilizes NRARP and ESM1 expression. The study proposes circMET as a biomarker and therapeutic target for proliferative retinopathies and other neovascular diseases."	0.7519
35001875	Cancer biomarkers : section A of Disease markers	2022	Hsa_circ_0003288 facilitates tumor progression by targeting miR-145 in non-small cell lung cancer cells.	hsa_circ_0003288	circ_0003288	hsa_circ_BIRC6	BIRC6	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0003288 is up-regulated in NSCLC tissues and lung cancer cell lines. It functions as an oncogenic circRNA that promotes proliferation, colony formation, migration, invasion and tumor growth while suppressing apoptosis. Mechanistically, it directly targets and negatively regulates miR-145, forming a hsa_circ_0003288/miR-145 axis in NSCLC progression."	0.6536
35015290	"Reproductive sciences (Thousand Oaks, Calif.)"	2022	A Novel Circular RNA CircBRAP May Be Used as an Early Predictor of Preeclampsia and Its Potential Mechanism.		CircBRAP	hsa_circ_BRAP	BRAP	Preeclampsia / PE	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR; Microarray	"CircBRAP is up-regulated in plasma and placental samples from preeclampsia patients and may serve as an early predictive biomarker when combined with sFLT1 and uterine artery Doppler ultrasound findings. Functionally, CircBRAP inhibits trophoblast proliferation, invasion, and cell cycle progression while promoting apoptosis. Mechanistically, CircBRAP coregulates sFLT1 expression through miR-106b and HIF-2alpha pathways, and EIF4A3 may contribute to CircBRAP upregulation."	0.8868
35021128	International immunopharmacology	2022	Circ_0000647 promotes cell injury by modulating miR-126-5p/TRAF3 axis in oxygen-glucose deprivation and reperfusion-induced SK-N-SH cell model.	hsa_circ_0000647	circ_0000647	hsa_circ_SEC11A	SEC11A	ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR	"circ_0000647 is up-regulated in OGD/R-induced SK-N-SH cells and promotes cell injury by suppressing proliferation while enhancing apoptosis, inflammation and oxidative stress. Mechanistically, circ_0000647 sponges miR-126-5p to relieve repression of TRAF3, and exosomes participate in circ_0000647 transmission in this in vitro ischemic stroke model."	0.6959
35027669	Oncogene	2022	Exosomal circCARM1 from spheroids reprograms cell metabolism by regulating PFKFB2 in breast cancer.	hsa_circ_0004552	circCARM1 / circ_0004552	hsa_circ_CARM1	CARM1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; ISH; Microarray	"This study identifies exosomal circCARM1 as an up-regulated circRNA in breast cancer spheroid/BCSC-derived exosomes and in breast cancer tissues. circCARM1 promotes breast cancer glycolysis, proliferation/survival, and tumor growth through a ceRNA mechanism involving miR-1252-5p and PFKFB2, while EIF4A3 supports circCARM1 biogenesis."	0.8816
35033901	Reproductive biology	2022	The novel circ_0084904/miR-802/MAL2 axis promotes the development of cervical cancer.	hsa_circ_0084904	circ_0084904	hsa_circ_KIAA1429		cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"circ_0084904 is up-regulated in cervical cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes malignant phenotypes including proliferation, cell cycle progression, migration, invasion, EMT, glycolysis, and tumor growth while suppressing apoptosis, mainly through the circ_0084904/miR-802/MAL2 regulatory axis. Its high diagnostic value and functional inhibition by silencing suggest potential clinical utility as a biomarker and therapeutic target."	0.8353
35037032	Journal of biochemistry	2022	Circ_0000190 sponges miR-382-5p to suppress cell proliferation and motility and promote cell death by targeting ZNRF3 in gastric cancer.	hsa_circ_0000190		hsa_circ_CNIH4	CNIH4	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"Circ_0000190 is down-regulated in gastric cancer tissues and cell lines, and low expression is associated with advanced TNM stage and worse survival. Functionally, circ_0000190 suppresses proliferation, migration, invasion and xenograft tumor growth while promoting ferroptosis and apoptosis. Mechanistically, it sponges miR-382-5p to up-regulate ZNRF3 expression in GC cells."	0.8465
35037694	Histology and histopathology	2022	Circ_0044520 regulates the progression of laryngeal squamous cell carcinoma via the miR-338-3p/ROR2 axis.	hsa_circ_0044520				laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR	"circ_0044520 is up-regulated in LSCC tissues and cell lines and is associated with tumor size, clinical stage, and lymph node metastasis. Functional experiments indicate that circ_0044520 promotes malignant LSCC phenotypes by enhancing proliferation, cell-cycle progression, angiogenesis and tumor growth while suppressing apoptosis. Mechanistically, circ_0044520 sponges miR-338-3p to regulate ROR2 expression through a circ_0044520/miR-338-3p/ROR2 ceRNA axis."	0.6544
35038580	Molecular therapy : the journal of the American Society of Gene Therapy	2022	Exosome-derived circTRPS1 promotes malignant phenotype and CD8+ T cell exhaustion in bladder cancer microenvironments.	hsa_circ_0085361	circTRPS1	hsa_circ_TRPS1	TRPS1	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"This study identifies hsa_circ_0085361/circTRPS1 as an up-regulated exosome-derived circRNA in bladder cancer tissues and serum/urine exosomes. circTRPS1 promotes BCa proliferation, invasion, metastasis, and CD8+ T cell exhaustion by sponging miR-141-3p to enhance GLS1-mediated glutamine metabolism and redox regulation. High circTRPS1 expression is associated with poor overall survival and aggressive clinicopathological features, supporting its potential as a biomarker and therapeutic target."	0.8879
35038619	Tissue & cell	2022	Circular RNA circFOXO3 facilitate non-small cell lung cancer progression through upregulating HMGB3 via sponging miR-545-3p/miR-506-3p.		circFOXO3	hsa_circ_FOXO3	FOXO3	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circFOXO3 is up-regulated in NSCLC tissues and cell lines, and high expression is associated with poorer survival and aggressive clinicopathological features. Functionally, circFOXO3 promotes proliferation, migration, invasion and xenograft tumor growth by sponging miR-545-3p and miR-506-3p, thereby relieving repression of HMGB3."	0.7113
35041543	Human & experimental toxicology	2022	Circ_0006220 promotes non-small cell lung cancer progression via sponging miR-203-3p and regulating RGS17 expression.	hsa_circ_0006220	circ_0006220			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0006220 is up-regulated in NSCLC tissues and cell lines and is associated with unfavorable clinicopathological features. Functionally, it promotes NSCLC cell growth, proliferation, migration, and invasion. Mechanistically, circ_0006220 acts as a cytoplasmic miR-203-3p sponge to increase RGS17 expression through a circ_0006220/miR-203-3p/RGS17 ceRNA axis."	0.7404
35045525	Anti-cancer drugs	2022	Lidocaine hampers colorectal cancer process via circITFG2/miR-1204/SOCS2 axis.	hsa_circ_0000374	circITFG2 / Circular RNA integrin alpha FG-GAP repeat containing 2	hsa_circ_ITFG2	ITFG2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"circITFG2 is down-regulated in colorectal cancer cells and tissues and acts as a tumor suppressive circRNA. It inhibits proliferation, colony formation, migration and invasion while promoting apoptosis, and it mediates lidocaine-induced anti-CRC effects through the circITFG2/miR-1204/SOCS2 axis."	0.7294
35045986	Cancer research	2022	CircRPN2 Inhibits Aerobic Glycolysis and Metastasis in Hepatocellular Carcinoma.	hsa_circ_0007746	circRPN2	hsa_circ_RPN2	RPN2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; ISH; RNA-seq	"CircRPN2 is a human HCC-associated circular RNA that is downregulated in metastatic or recurrent HCC and in highly metastatic HCC cell lines. It suppresses aerobic glycolysis, proliferation, migration, invasion, progression, and metastasis by binding ENO1 to promote ubiquitin/proteasome-dependent degradation and by sponging miR-183-5p to increase FOXO1 expression. Clinically, higher circRPN2 expression is associated with better survival and lower recurrence, supporting its role as a prognostic biomarker and potential therapeutic target."	0.9003
35048805	Current molecular medicine	2023	Breviscapine Combined with BMSCs Reduces Abeta Deposition in Rat with Alzheimer's Disease by Regulating Circular RNA ciRS-7.		circular RNA ciRS-7 / ciRS-7			Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR	"ciRS-7 is downregulated in AD rat brain tissue and is increased by breviscapine or BMSCs treatment. Functionally, ciRS-7 reduces Abeta deposition by activating NF-kB signaling, promoting UCHL1 expression, and enhancing degradation of APP and BAEC1 proteins."	0.3957
35060113	Histology and histopathology	2022	Lidocaine represses the malignant behavior of lung carcinoma cells via the circ_PDZD8/miR-516b-5p/GOLT1A axis.	hsa_circ_0020123	circ_PDZD8	hsa_circ_PDZD8	PDZD8	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circ_PDZD8 is up-regulated in lung carcinoma cell lines and is reduced by lidocaine treatment. Functionally, circ_PDZD8 counteracts lidocaine-induced suppression of proliferation, migration, invasion and xenograft growth, while reducing apoptosis. Mechanistically, it sponges miR-516b-5p to increase GOLT1A expression, forming the circ_PDZD8/miR-516b-5p/GOLT1A axis."	0.786
35061326	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2022	Estrogen receptor beta increases clear cell renal cell carcinoma stem cell phenotype via altering the circPHACTR4/miR-34b-5p/c-Myc signaling.	hsa_circ_000570	circPHACTR4		PHACTR4	clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	down-regulated	RT-qPCR; ISH	"circPHACTR4 is down-regulated by ERbeta in ccRCC and mainly localized in the cytoplasm. It binds miR-34b-5p and appears to act as a miRNA reservoir/stabilizer, thereby reducing c-Myc expression and suppressing CSC phenotypes and ccRCC progression."	0.8674
35064304	Inflammation research : official journal of the European Histamine Research Society ... [et al.]	2022	Estrogen receptor beta2 (ERbeta2)-mediated upregulation of hsa_circ_0000732 promotes tumor progression via sponging microRNA-1184 in triple-negative breast cancer (TNBC).	hsa_circ_0000732		hsa_circ_SCARF1	SCARF1	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"hsa_circ_0000732 is up-regulated in TNBC tissues and in selected TNBC cell lines. ERbeta2 positively regulates hsa_circ_0000732 by binding to the SCARF1 promoter, and hsa_circ_0000732 promotes TNBC cell proliferation, migration, and invasion by sponging miR-1184."	0.7032
35066758	Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico	2022	Roles of circ_0000135/miR-140-3p/PDZK1 network in cervical cancer.	hsa_circ_0000135	circ_0000135	hsa_circ_MT1X	MT1X	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; RNA-seq	"circ_0000135 is up-regulated in cervical cancer tissues and cell lines and is associated with advanced clinicopathological features. The study supports a circ_0000135/miR-140-3p/PDZK1 ceRNA mechanism in which circ_0000135 promotes proliferation, cell cycle progression, migration, invasion and tumor growth, while silencing circ_0000135 suppresses cervical cancer progression."	0.7657
35068445	Cancer biomarkers : section A of Disease markers	2022	Exosome-delivered circular RNA DLGAP4 induces chemoresistance via miR-143-HK2 axis in neuroblastoma.		circular RNA DLGAP4 (circDLGAP4) / circDLGAP4	hsa_circ_DLGAP4	DLGAP4	Neuroblastoma / NB	MONDO:0005072	neuroblastoma	up-regulated	RT-qPCR	"This study identifies exosome-delivered circDLGAP4 as an up-regulated circRNA in doxorubicin-resistant neuroblastoma contexts. Drug-resistant neuroblastoma cell-derived exosomes transfer circDLGAP4 to sensitive cells, where it sponges miR-143 and promotes HK2 expression, increasing glycolysis, invasion, colony formation, and chemoresistance. Knockdown of exosomal circDLGAP4 reverses these malignant and drug-resistant phenotypes, suggesting circDLGAP4 as a potential therapeutic target for chemoresistant neuroblastoma."	0.6536
35072545	The International journal of biological markers	2022	CircFOXP1: A novel serum diagnostic biomarker for non-small cell lung cancer.	hsa_circ_0008234	circFOXP1	hsa_circ_FOXP1	FOXP1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"Serum circFOXP1 (hsa_circ_0008234) is significantly up-regulated in NSCLC and shows diagnostic value superior to CEA and CYFRA21-1 in this cohort. It is associated with T stage and lymphatic metastasis, and bioinformatics plus cell transfection/qRT-PCR analyses suggest that it may act through hsa-miR-370-3p and hsa-miR-18a-5p in VEGF-related proliferative and metastatic processes."	0.591
35076819	Metabolic brain disease	2022	Circ_0003611 acts as a miR-885-5p sponge to aggravate the amyloid-beta-induced neuronal injury in Alzheimer's disease.	hsa_circ_0003611	circ_0003611	hsa_circ_LPAR1	LPAR1	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR	"circ_0003611 is up-regulated in serum from AD patients and in Abeta-treated SK-N-SH cells. It aggravates Abeta-induced neuronal injury by promoting apoptosis, inflammatory cytokine release, and oxidative damage. Mechanistically, circ_0003611 sponges miR-885-5p to increase KREMEN1 expression, forming a circ_0003611/miR-885-5p/KREMEN1 regulatory axis."	0.7785
35076912	Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics	2022	[Effect of circ-SFMBT2 on the biological behavior of non-small cell lung cancer cells by targeting the miR-7-5p/ADAM10 axis].		circ-SFMBT2	hsa_circ_SFMBT2	SFMBT2	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	unknown	RT-qPCR	This study investigated circ-SFMBT2 in non-small cell lung cancer cells. The available title indicates that circ-SFMBT2 affects NSCLC cell biological behavior by targeting the miR-7-5p/ADAM10 axis.	0.5223
35077682	Clinical biochemistry	2022	Serum exosomal hsa_circ_0069313 has a potential to diagnose more aggressive non-small cell lung cancer.	hsa_circ_0069313	circPACRGL	hsa_circ_PACRGL	PACRGL	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0069313 was validated by qRT-PCR as up-regulated in serum and serum exosomes of NSCLC patients. Its serum and serum exosomal levels showed diagnostic potential for distinguishing NSCLC from benign lung tumor, and higher serum exosomal levels were associated with more aggressive NSCLC features including advanced stage and metastasis."	0.5047
35077682	Clinical biochemistry	2022	Serum exosomal hsa_circ_0069313 has a potential to diagnose more aggressive non-small cell lung cancer.	hsa_circ_0063526	circ-RanGAP1	hsa_circ_RanGAP1	RanGAP1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	dysregulated	Microarray	"hsa_circ_0063526 was selected as one of five serum exosomal circRNAs of interest through circRNA array screening and literature intersection. In this study, it was not carried forward for NSCLC patient-cohort qRT-PCR validation, so its NSCLC association is supported only by screening-level evidence."	0.1768
35077682	Clinical biochemistry	2022	Serum exosomal hsa_circ_0069313 has a potential to diagnose more aggressive non-small cell lung cancer.	hsa_circ_0010522	ciRS-133			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	dysregulated	Microarray	"hsa_circ_0010522 was selected as one of five serum exosomal circRNAs of interest through circRNA array screening and literature intersection. In this study, it was not carried forward for NSCLC patient-cohort qRT-PCR validation, so its NSCLC association is supported only by screening-level evidence."	0.1768
35077682	Clinical biochemistry	2022	Serum exosomal hsa_circ_0069313 has a potential to diagnose more aggressive non-small cell lung cancer.	hsa_circ_0048677	cir-cUHRF1	hsa_circ_UHRF1	UHRF1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	dysregulated	Microarray	"hsa_circ_0048677 was selected as one of five serum exosomal circRNAs of interest through circRNA array screening and literature intersection. In this study, it was not carried forward for NSCLC patient-cohort qRT-PCR validation, so its NSCLC association is supported only by screening-level evidence."	0.1768
35077682	Clinical biochemistry	2022	Serum exosomal hsa_circ_0069313 has a potential to diagnose more aggressive non-small cell lung cancer.	hsa_circ_0001946	circ Cdr1as	hsa_circ_Cdr1as	Cdr1as	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	dysregulated	Microarray	"hsa_circ_0001946 was selected as one of five serum exosomal circRNAs of interest through circRNA array screening and literature intersection. In this study, it was not carried forward for NSCLC patient-cohort qRT-PCR validation, so its NSCLC association is supported only by screening-level evidence."	0.1768
35086110	Nephron	2022	Circ_0039569 Competes with MARCKS for miR-133b Binding Sites to Promote the Progression of Renal Cell Carcinoma.	hsa_circ_0039569	circ_0039569	hsa_circ_CCL22	CCL22	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR	"circ_0039569 is up-regulated in RCC tissues and cells and is associated with more advanced TNM stage, invasion depth, and shorter overall survival. It promotes RCC proliferation, migration, invasion and xenograft tumor growth while suppressing apoptosis, acting through a miR-133b/MARCKS ceRNA axis."	0.8201
35089074	Genetic testing and molecular biomarkers	2022	Has_Circ_0002490 Circular RNA: A Potential Novel Biomarker for Lung Cancer.	hsa_circ_0002490	circRNA2490			lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	"has_circ_0002490 was downregulated in lung cancer tissues and showed the strongest single-marker diagnostic performance among the five circRNAs tested. Its lower expression was associated with advanced TNM stage and gender, suggesting potential clinical utility as a diagnostic biomarker."	0.4187
35089074	Genetic testing and molecular biomarkers	2022	Has_Circ_0002490 Circular RNA: A Potential Novel Biomarker for Lung Cancer.	hsa_circ_0087357				lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	"has_circ_0087357 was downregulated in lung cancer tissues and had diagnostic potential with an AUC of 0.793. Lower expression was associated with advanced TNM stage and gender, but its biological function and molecular mechanism were not investigated."	0.4187
35089074	Genetic testing and molecular biomarkers	2022	Has_Circ_0002490 Circular RNA: A Potential Novel Biomarker for Lung Cancer.	hsa_circ_0004891				lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	"has_circ_0004891 was downregulated in lung cancer tissues and showed diagnostic potential with an AUC of 0.730. Its lower expression was associated with advanced TNM stage, while biological mechanism and function were not characterized."	0.4187
35089074	Genetic testing and molecular biomarkers	2022	Has_Circ_0002490 Circular RNA: A Potential Novel Biomarker for Lung Cancer.	hsa_circ_0074368				lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	has_circ_0074368 was downregulated in lung cancer tissues and could distinguish lung cancer tissues from adjacent normal tissues with an AUC of 0.773. Its biological function and molecular mechanism were not tested in this study.	0.4187
35089074	Genetic testing and molecular biomarkers	2022	Has_Circ_0002490 Circular RNA: A Potential Novel Biomarker for Lung Cancer.	hsa_circ_0000896				lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR	"has_circ_0000896 was downregulated in lung cancer tissues and showed modest diagnostic potential with an AUC of 0.645. Lower expression was associated with advanced TNM stage, but the study did not determine its biological mechanism."	0.4187
35091088	Biomedical journal	2023	"Circ_0011385 knockdown inhibits cell proliferation, migration and invasion, whereas promotes cell apoptosis by regulating miR-330-3p/MYO6 axis in colorectal cancer."	hsa_circ_0011385	circ_0011385	hsa_circ_EIF3I	EIF3I	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"Circ_0011385 is up-regulated in colorectal cancer tissues and cells and functions as an oncogenic circRNA. It promotes CRC cell proliferation, migration, invasion, cell cycle progression and xenograft tumor growth while suppressing apoptosis, mainly through the miR-330-3p/MYO6 axis and MEK1/2/ERK1/2 signaling pathway."	0.8645
35091089	Pharmacological research	2022	Endoplasmic reticulum stress promotes breast cancer cells to release exosomes circ_0001142 and induces M2 polarization of macrophages to regulate tumor progression.	hsa_circ_0001142	circ_0001142 / circ-PIGU	hsa_circ_PIGU	PIGU	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0001142/hsa_circ_0001142 is up-regulated in breast cancer tissues and cell lines and functions as an oncogenic circRNA. It is transferred from breast cancer cells to macrophages via exosomes, sponges miR-361-3p to regulate PIK3CB and PI3K/AKT signaling, inhibits autophagy, induces M2 macrophage polarization, and promotes tumor growth, metastasis, EMT and glycolysis. Its high expression is associated with advanced TNM stage, lymphatic metastasis and poor prognosis, suggesting biomarker and therapeutic potential."	0.8748
35093599	Annals of hepatology	2022	Circ-LARP1B knockdown restrains the tumorigenicity and enhances radiosensitivity by regulating miR-578/IGF1R axis in hepatocellular carcinoma.	hsa_circ_0070934	circ-LARP1B / hsa_circRNA_103737	hsa_circ_LARP1B	LARP1B	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circ-LARP1B is up-regulated in HCC tissues and cells, and its high expression predicts poor overall survival. Functionally, circ-LARP1B promotes HCC tumorigenic phenotypes and radioresistance; knockdown suppresses proliferation, invasion, angiogenesis and tumor growth while enhancing radiosensitivity. Mechanistically, cytoplasmic circ-LARP1B sponges miR-578 to up-regulate IGF1R."	0.8156
35098410	Biochemical genetics	2022	"Circ_0009910 Serves as miR-361-3p Sponge to Promote the Proliferation, Metastasis, and Glycolysis of Gastric Cancer via Regulating SNRPA."	hsa_circ_0009910	Circ_0009910	hsa_circ_MFN2	MFN2	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_0009910 is up-regulated in gastric cancer tissues and cell lines. It promotes proliferation, migration, invasion, glycolysis, metastasis-related phenotypes and in vivo tumor growth while suppressing apoptosis. Mechanistically, circ_0009910 sponges miR-361-3p to positively regulate SNRPA, suggesting that targeted inhibition of circ_0009910 may be therapeutically relevant in GC."	0.8295
35101892	"Journal of immunology (Baltimore, Md. : 1950)"	2022	Exon-Intron Circular RNA circRNF217 Promotes Innate Immunity and Antibacterial Activity in Teleost Fish by Reducing miR-130-3p Function.		circRNA RNF217	miiuy_circ_RNF217	RNF217	Vibrio anguillarum infection 	MONDO:0007014	vibrio infectious disease	up-regulated	RT-qPCR; RNA-seq	"circRNF217 is a stable exon-intron circRNA derived from RNF217 and is up-regulated during V. anguillarum/LPS challenge and SCRV infection in miiuy croaker models. It acts as a miR-130-3p sponge to increase NOD1 expression, activate innate immune signaling, reduce bacterial invasion, and inhibit viral replication."	0.8058
35101892	"Journal of immunology (Baltimore, Md. : 1950)"	2022	Exon-Intron Circular RNA circRNF217 Promotes Innate Immunity and Antibacterial Activity in Teleost Fish by Reducing miR-130-3p Function.		circRNA RNF217	miiuy_circ_RNF217	RNF217	Siniperca chuatsi rhabdovirus infection	MONDO:0005108	viral infectious disease	up-regulated	RT-qPCR; RNA-seq	"circRNF217 is a stable exon-intron circRNA derived from RNF217 and is up-regulated during V. anguillarum/LPS challenge and SCRV infection in miiuy croaker models. It acts as a miR-130-3p sponge to increase NOD1 expression, activate innate immune signaling, reduce bacterial invasion, and inhibit viral replication."	0.8058
35106879	The journal of gene medicine	2022	Circ_0072088 knockdown contributes to cisplatin sensitivity and inhibits tumor progression by miR-944/LASP1 axis in non-small cell lung cancer.	hsa_circ_0072088	circ_0072088 / circZFR	hsa_circ_ZFR		non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"Circ_0072088 is upregulated in CDDP-resistant NSCLC tissues and cells. It promotes cisplatin resistance and malignant phenotypes by sponging miR-944 and increasing LASP1 expression, while circ_0072088 knockdown enhances CDDP sensitivity and suppresses tumor progression in vitro and in vivo."	0.78
35120971	The Journal of allergy and clinical immunology	2022	CircZNF652 promotes the goblet cell metaplasia by targeting the miR-452-5p/JAK2 signaling pathway in allergic airway epithelia.	hsa_circ_0000782	circZNF652	hsa_circ_ZNF652	ZNF652	asthma	MONDO:0004979	asthma	up-regulated	RT-qPCR; ISH; Microarray	"circZNF652 is up-regulated in airway epithelia from children with asthma and OVA-induced allergic airway inflammation mouse models. It promotes goblet cell metaplasia and airway remodeling by sponging miR-452-5p, thereby increasing JAK2 expression and activating JAK2/STAT6 signaling; ESRP1 promotes its biogenesis by binding flanking intronic motifs."	0.8398
35120971	The Journal of allergy and clinical immunology	2022	CircZNF652 promotes the goblet cell metaplasia by targeting the miR-452-5p/JAK2 signaling pathway in allergic airway epithelia.	mmu_circ_0003573	circZNF652	mmu_circ_ZNF652	ZNF652	asthma	MONDO:0004979	asthma	up-regulated	RT-qPCR; ISH; Microarray	"circZNF652 is up-regulated in airway epithelia from children with asthma and OVA-induced allergic airway inflammation mouse models. It promotes goblet cell metaplasia and airway remodeling by sponging miR-452-5p, thereby increasing JAK2 expression and activating JAK2/STAT6 signaling; ESRP1 promotes its biogenesis by binding flanking intronic motifs."	0.8398
35121166	Placenta	2022	Circular RNA expression profile and competing endogenous RNA regulatory network in preeclampsia.	hsa_circ_0001687				preeclampsia / PE	MONDO:0005081	preeclampsia	up-regulated	Microarray	"hsa_circ_0001687 was identified as an up-regulated circRNA in PE placental tissue by integrated microarray/GEO analysis, although its RT-qPCR validation was not concordant. The authors proposed that it may act as a ceRNA for hsa-miR-532-3p to regulate MMP14 and AXL and thereby participate in PE pathology."	0.348
35121166	Placenta	2022	Circular RNA expression profile and competing endogenous RNA regulatory network in preeclampsia.	hsa_circ_0001513		hsa_circ_LNPEP	LNPEP	preeclampsia / PE	MONDO:0005081	preeclampsia	down-regulated	RT-qPCR; Microarray	hsa_circ_0001513 was down-regulated in PE placental tissue and its expression pattern was consistent with RT-qPCR validation. The study proposed that it may function as a ceRNA involving hsa-miR-188-5p/HMGCS1 and hsa-miR-760/MAP1LC3B axes in PE.	0.4032
35121166	Placenta	2022	Circular RNA expression profile and competing endogenous RNA regulatory network in preeclampsia.	hsa_circ_0001329				preeclampsia / PE	MONDO:0005081	preeclampsia	down-regulated	RT-qPCR; Microarray	"hsa_circ_0001329 was down-regulated in PE placental tissue and was validated by RT-qPCR and GEO dataset analysis. The authors proposed that it may participate in PE through a ceRNA mechanism involving hsa-miR-760 and MAP1LC3B, and ROC analysis suggested potential diagnostic value."	0.5047
35121166	Placenta	2022	Circular RNA expression profile and competing endogenous RNA regulatory network in preeclampsia.	hsa_circ_0079212				preeclampsia / PE	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR; Microarray	hsa_circ_0079212 was identified as an up-regulated DEcircRNA in PE placental tissue and its expression pattern was consistent with RT-qPCR validation. The study did not report a specific ceRNA axis or functional mechanism for this circRNA.	0.3588
35121166	Placenta	2022	Circular RNA expression profile and competing endogenous RNA regulatory network in preeclampsia.	hsa_circ_0057364				preeclampsia / PE	MONDO:0005081	preeclampsia	up-regulated	Microarray	"hsa_circ_0057364 was reported as the most up-regulated circRNA in PE based on integrated circRNA microarray analysis of placental tissues. No RT-qPCR validation, mechanism, or functional experiment specific to this circRNA was reported."	0.1768
35121166	Placenta	2022	Circular RNA expression profile and competing endogenous RNA regulatory network in preeclampsia.	hsa_circ_0001235				preeclampsia / PE	MONDO:0005081	preeclampsia	down-regulated	Microarray	"hsa_circ_0001235 was reported as the most down-regulated circRNA in PE based on integrated circRNA microarray analysis of placental tissues. No RT-qPCR validation, mechanism, or functional experiment specific to this circRNA was reported."	0.1768
35122957	Transplant immunology	2022	Andrographolide suppresses osteoarthritis progression by regulating circ_Rapgef1/miR-383-3p/NLRP3 signaling axis.		circ_Rapgef1 / circRNA Rap guanine nucleotide exchange factor 1	mmu_circ_Rapgef1	Rapgef1	osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"Circ_Rapgef1 is up-regulated in mouse osteoarthritis synovial tissues and LPS-induced osteoarthritis chondrocyte models, while andrographolide decreases its expression. Functionally, circ_Rapgef1 counteracts andrographolide-mediated protection by reducing proliferation and promoting apoptosis and inflammatory responses. Mechanistically, it sponges miR-383-3p to increase NLRP3 mRNA and protein expression."	0.6966
35131381	Cancer letters	2022	"YAP derived circ-LECRC functions as a ""brake signal"" to suppress hyperactivation of oncogenic YAP signalling in colorectal cancer."	hsa_circ_0004140	circ-LECRC	hsa_circ_YAP1	YAP1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; ISH	"Circ-LECRC is a YAP1-derived circRNA that is downregulated in colorectal cancer and acts as a tumor suppressor. It sponges miR-135b-5p to increase KLF4 expression, thereby inhibiting oncogenic YAP1 signalling and reducing proliferation, migration, invasion, tumorigenicity, and lung metastasis while promoting apoptosis. Clinically, higher circ-LECRC expression is associated with lower TNM stage and better survival prognosis."	0.887
35133000	Histology and histopathology	2022	Depleting hsa_circ_0000567 suppresses acquired gefitinib resistance and proliferation of lung adenocarcinoma cells through regulating the miR-377-3p / ZFX axis: an in vitro and in vivo study.	hsa_circ_0000567	circ_0000567	hsa_circ_SETD3	SETD3	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"hsa_circ_0000567 is up-regulated in LUAD and further elevated in gefitinib-resistant LUAD tissues and cells. Its depletion suppresses gefitinib resistance, proliferation, colony formation, and xenograft tumor growth while promoting apoptosis, acting through a hsa_circ_0000567/miR-377-3p/ZFX ceRNA mechanism. Clinically, higher hsa_circ_0000567 is associated with advanced tumor burden, suggesting potential biomarker and therapeutic relevance in gefitinib-resistant LUAD."	0.7591
35138469	Biochemical genetics	2022	Exosomal circ_0001190 Regulates the Progression of Gastric Cancer via miR-586/SOSTDC1 Axis.	hsa_circ_0001190	circ_0001190			gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"circ_0001190 is downregulated in gastric cancer tissues, GC cell lines, and patient plasma/serum exosomes, and low expression is associated with worse survival. Exosomal circ_0001190 suppresses GC progression by sponging miR-586 and increasing SOSTDC1, thereby inhibiting proliferation, angiogenesis, migration, invasion and tumor growth while promoting apoptosis. The study suggests circ_0001190 may be a prognostic marker and potential therapeutic target in GC."	0.8354
35142935	Journal of molecular histology	2022	Circ_0120175 promotes laryngeal squamous cell carcinoma development through up-regulating SLC7A11 by sponging miR-330-3p.	hsa_circ_0120175	circ_0120175			laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ_0120175 is up-regulated in LSCC tissues and cell lines and acts as an oncogenic circRNA. It promotes proliferation, migration, invasion and xenograft tumor growth while inhibiting apoptosis through the circ_0120175/miR-330-3p/SLC7A11 ceRNA axis. High expression is associated with advanced tumor staging, lymph node metastasis and poorer survival."	0.7369
35164417	Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases	2021	[Differential on N6-methyladenosine modification of circRNA in early inflammation of silicosis].		circSLC2A13		SLC2A13	silicosis	MONDO:0005960	silicosis	up-regulated	RT-qPCR	"This study identified circSLC2A13 as a target circRNA related to early inflammation of silicosis after m6A-circRNA microarray screening and additional experimental/bioinformatic selection. In SiO2-stimulated THP-1-derived macrophages, circSLC2A13 expression was significantly increased at 0.5 h, and its m6A modification level was significantly increased at 6 h."	0.5803
35164417	Zhonghua lao dong wei sheng zhi ye bing za zhi = Zhonghua laodong weisheng zhiyebing zazhi = Chinese journal of industrial hygiene and occupational diseases	2021	[Differential on N6-methyladenosine modification of circRNA in early inflammation of silicosis].		circSLC2A13		SLC2A13	silicosis	MONDO:0005960	silicosis	up-regulated	RT-qPCR	"This study identified circSLC2A13 as a target circRNA related to early inflammation of silicosis after m6A-circRNA microarray screening and additional experimental/bioinformatic selection. In SiO2-stimulated THP-1-derived macrophages, circSLC2A13 expression was significantly increased at 0.5 h, and its m6A modification level was significantly increased at 6 h."	0.5803
35167942	Neuroscience letters	2022	Circular RNA AXL increases neuron injury and inflammation through targeting microRNA-328 mediated BACE1 in Alzheimer's disease.	hsa_circ_0002945	circ-AXL / circ_0002945	hsa_circ_AXL	AXL	Alzheimer's Disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR; Microarray	"circ-AXL is up-regulated in amyloid beta-induced cellular AD models. It aggravates neuronal injury and neuroinflammation by sponging miR-328 and thereby increasing BACE1 expression, leading to increased apoptosis and inflammatory cytokines and reduced neurite outgrowth. The circ-AXL/miR-328/BACE1 axis is proposed as a potential therapeutic target in Alzheimer's disease."	0.6436
35168080	International immunopharmacology	2022	Downregulation of mmu_circ_0000943 ameliorates renal ischemia reperfusion-triggered inflammation and oxidative stress via regulating mmu-miR-377-3p/Egr2 axis.	mmu_circ_0000943		mmu_circ_Glis3	Glis3	acute kidney injury / AKI	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR; RNA-seq; Microarray	"mmu_circ_0000943 is up-regulated in renal IRI tissues and H/R-treated TKPTS cells. It aggravates H/R-induced renal tubular cell injury by promoting apoptosis, inflammatory cytokine expression and oxidative stress. Mechanistically, it acts as a ceRNA sponge for miR-377-3p to regulate Egr2 expression through the mmu_circ_0000943/miR-377-3p/Egr2 axis."	0.6737
35172608	Epigenomics	2022	circPlekha7 suppresses renal fibrosis via targeting miR-493-3p/KLF4.		circPlekha7	hsa_circ_Plekha7	Plekha7	renal fibrosis	MONDO:0000494	renal fibrosis	down-regulated	RT-qPCR	"circPlekha7 is down-regulated in CKD renal tissues and TGF-beta1-induced renal fibrosis models. It acts as an anti-fibrotic circRNA by sponging miR-493-3p, thereby relieving repression of KLF4/Mfn2 and suppressing EMT, fibrogenesis, cell proliferation/migration and mitochondrial injury. The circPlekha7/miR-493-3p/KLF4 axis is proposed as a potential diagnostic marker or therapeutic target for CKD."	0.7554
35172608	Epigenomics	2022	circPlekha7 suppresses renal fibrosis via targeting miR-493-3p/KLF4.		circPlekha7	mmu_circ_Plekha7	Plekha7	renal fibrosis	MONDO:0000494	renal fibrosis	down-regulated	RT-qPCR	"circPlekha7 is down-regulated in CKD renal tissues and TGF-beta1-induced renal fibrosis models. It acts as an anti-fibrotic circRNA by sponging miR-493-3p, thereby relieving repression of KLF4/Mfn2 and suppressing EMT, fibrogenesis, cell proliferation/migration and mitochondrial injury. The circPlekha7/miR-493-3p/KLF4 axis is proposed as a potential diagnostic marker or therapeutic target for CKD."	0.7554
35179434	Immunopharmacology and immunotoxicology	2022	Circ_0067934 reduces JNK phosphorylation through a microRNA-545-3p/PPA1 axis to enhance tumorigenesis and cisplatin resistance in ovarian cancer.	hsa_circ_0067934	circ_0067934			ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; ISH	"circ_0067934 is up-regulated in ovarian cancer tissues, ovarian cancer cell lines, and cisplatin-resistant A2780/DDP cells. It promotes proliferation, invasion, tumor growth, and cisplatin/DDP resistance while suppressing apoptosis by sponging miR-545-3p, increasing PPA1 expression, and reducing JNK phosphorylation. Clinically, high circ_0067934 expression is associated with lymph node metastasis and advanced tumor staging."	0.8037
35180547	Archives of oral biology	2022	Silencing of circ_OSBPL10 affects the functional behaviors of oral squamous cell carcinoma cells by the miR-299-3p/CDK6 axis.	hsa_circ_0008549	circRNA oxysterol binding protein like 10 / cir-c_OSBPL10	hsa_circ_OSBPL10	OSBPL10	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circ_OSBPL10 is up-regulated in OSCC tissues and cells and functions as an oncogenic circRNA. It promotes proliferation, cell-cycle progression, colony formation, migration, invasion and in vivo tumor growth while suppressing apoptosis, at least partly through the circ_OSBPL10/miR-299-3p/CDK6 ceRNA axis. The study proposes circ_OSBPL10 inhibition as a potential therapeutic strategy for OSCC."	0.7183
35181394	Neurochemistry international	2022	Circular RNA_0061587 is associated with the tumorigenesis of neurofibromatosis type 1.	hsa_circ_0061587	Circular RNA_0061587	hsa_circ_RUNX1	RUNX1	neurofibromatosis type 1 / NF1	MONDO:0018975	neurofibromatosis type 1	up-regulated	RT-qPCR	"circ_0061,587 is up-regulated in human NF1-associated MPNST cell lines and acts as an oncogenic circRNA. It promotes proliferation, migration and invasion while suppressing apoptosis by sponging miR-485-5p and increasing RUNX1 and ANXA11 expression. The study suggests circ_0061,587 may serve as a potential biomarker for NF1."	0.809
35181618	Annals of clinical and laboratory science	2022	Circ_0006873 Sponges miR-142-5p to Inhibit Osteoblastic Differentiation of hBMSCs via Regulating PTEN/Akt Signaling Pathway.	hsa_circ_0006873	Circ_0006873			Osteoporosis / OP	MONDO:0005298	osteoporosis	up-regulated	RT-qPCR	"circ_0006873 is up-regulated in serum from osteoporosis patients and decreases during osteoblastic differentiation of hBMSCs. Functionally, it suppresses hBMSC proliferation and osteoblastic differentiation by sponging miR-142-5p, increasing PTEN expression, and inhibiting Akt signaling, suggesting potential therapeutic biomarker value in osteoporosis."	0.6903
35181624	Annals of clinical and laboratory science	2022	miR-485-5p Induces HSP90 Ubiquitination to Impede Circular RNAcircHIPK2 Associated Cell Proliferation of Non-Small Cell Lung Cancer: Therapeutic Implications.		circHIPK2	hsa_circ_HIPK2	HIPK2	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circHIPK2 is up-regulated in NSCLC tissues and cell lines, with higher expression associated with advanced stage and worse OS/DFS. Functionally, circHIPK2 promotes NSCLC cell proliferation, migration and invasion, likely through suppressing miR-485-5p and regulating HSP90 expression/function and ubiquitination."	0.7523
35187630	Histology and histopathology	2022	Hsa_circ_0048674 facilitates hepatocellular carcinoma progression and natural killer cell exhaustion depending on the regulation of miR-223-3p/PDL1.	hsa_circ_0048674	circUHRF1	hsa_circ_UHRF1	UHRF1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"hsa_circ_0048674 is up-regulated in HCC tissues and cell lines and is associated with tumor size, TNM stage and lymph node metastasis. It promotes HCC progression by acting as a miR-223-3p sponge to increase PDL1 expression, thereby enhancing proliferation, migration, invasion, angiogenesis and tumor growth while suppressing apoptosis. It also impairs NK cell functions, suggesting an immune regulatory role in HCC."	0.8443
35189704	Circulation research	2022	CircOGDH Is a Penumbra Biomarker and Therapeutic Target in Acute Ischemic Stroke.	hsa_circ_0003340	CircOGDH / circular RNA derived from oxoglutarate dehydrogenase	hsa_circ_OGDH	OGDH	ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; RNA-seq; Microarray	"CircOGDH is up-regulated in ischemic penumbra tissue and in plasma/plasma exosomes of patients with acute ischemic stroke. It promotes ischemic neuronal apoptosis and injury by sponging miR-5112 to increase COL4A4 expression, while knockdown improves neuronal viability and reduces injury. Clinically, circulating/exosomal CircOGDH is proposed as a sensitive and specific predictive biomarker for the presence and size of penumbra in AIS."	0.8817
35189704	Circulation research	2022	CircOGDH Is a Penumbra Biomarker and Therapeutic Target in Acute Ischemic Stroke.	mmu_circ_0000231	CircOGDH / circular RNA derived from oxoglutarate dehydrogenase	mmu_circ_OGDH	OGDH	ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; RNA-seq; Microarray	"CircOGDH is up-regulated in ischemic penumbra tissue and in plasma/plasma exosomes of patients with acute ischemic stroke. It promotes ischemic neuronal apoptosis and injury by sponging miR-5112 to increase COL4A4 expression, while knockdown improves neuronal viability and reduces injury. Clinically, circulating/exosomal CircOGDH is proposed as a sensitive and specific predictive biomarker for the presence and size of penumbra in AIS."	0.8817
35191745	Molecular and cellular biology	2022	circ_0001821 Contributes to the Development of Cutaneous Squamous Cell Carcinoma by Regulating MicroRNA-148a-3p/EGFR Axis and Activating Phosphatidylinositol 3-Kinase/Akt Pathway.	hsa_circ_0001821	circ_0001821			cutaneous squamous cell carcinoma / CSCC	MONDO:0002529	skin squamous cell carcinoma	up-regulated	RT-qPCR	"circ_0001821 is up-regulated in CSCC tissues and cells and functions as a tumor-promoting circRNA. Its knockdown suppresses CSCC malignant phenotypes and in vivo tumor growth by releasing miR-148a-3p, reducing EGFR expression, and blocking PI3K/Akt pathway activation. The study suggests circ_0001821 may be a therapeutic target for CSCC."	0.7296
35202487	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2022	Circular RNA circBFAR promotes glioblastoma progression by regulating a miR-548b/FoxM1 axis.		circular RNA bifunctional apoptosis regulator (circBFAR) / hsa_circ_00090655	hsa_circ_BFAR	BFAR	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; RNA-seq	"circBFAR is an up-regulated human circRNA derived from BFAR in GBM tissues and glioma cell lines. It promotes glioma proliferation, invasion, and in vivo tumor growth by acting as a ceRNA for miR-548b and increasing FoxM1 expression. High circBFAR expression is associated with worse overall survival in GBM patients."	0.8655
35213290	American journal of respiratory cell and molecular biology	2022	The Combined Effects of Circular RNA Methylation Promote Pulmonary Fibrosis.	hsa_circ_0000672	circ000672			pulmonary fibrosis	MONDO:0002771	pulmonary fibrosis	dysregulated	RT-qPCR; Microarray	"hsa_circ_0000672 is a human circRNA whose m6A modification, rather than expression abundance, is implicated in SiO2-induced pulmonary fibrosis. Together with hsa_circ_0005654, it is modified by METTL3 and binds eIF4A3, synergistically promoting pulmonary fibroblast activation and migration."	0.7296
35213290	American journal of respiratory cell and molecular biology	2022	The Combined Effects of Circular RNA Methylation Promote Pulmonary Fibrosis.	hsa_circ_0005654	circ0005654			pulmonary fibrosis	MONDO:0002771	pulmonary fibrosis	dysregulated	RT-qPCR; Microarray	"hsa_circ_0005654 is a human circRNA whose m6A modification, rather than expression abundance, is implicated in SiO2-induced pulmonary fibrosis. Together with hsa_circ_0000672, it is modified by METTL3 and binds eIF4A3, synergistically promoting pulmonary fibroblast activation and migration."	0.7296
35225648	Neoplasma	2022	"Circ_0020123 regulates autophagy, glycolysis, and malignancy by upregulating IRF4 through eliminating miR-193a-3p-mediated suppression of IRF4 in non-small cell lung cancer."	hsa_circ_0020123	circ_0020123	hsa_circ_PDZD8	PDZD8	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"Circ_0020123 is up-regulated in NSCLC tissues and cells, and high expression is associated with poor overall survival. Functionally, circ_0020123 promotes NSCLC tumor growth, proliferation, migration, and glycolysis while inhibiting apoptosis and autophagy. Mechanistically, it sponges miR-193a-3p to increase IRF4 expression, forming a circ_0020123/miR-193a-3p/IRF4 regulatory axis."	0.8438
35227787	Cancer letters	2022	Novel circular RNA circ_0086722 drives tumor progression by regulating the miR-339-5p/STAT5A axis in prostate cancer.	hsa_circ_0086722	circ_0086722	hsa_circ_UBAP2	UBAP2	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; Microarray	"circ_0086722 is an up-regulated UBAP2-derived circRNA in prostate cancer tissues and cell lines. It promotes PCa proliferation, migration, invasion and xenograft tumor growth by sponging miR-339-5p and increasing STAT5A expression. High circ_0086722 expression is associated with more advanced pathological features and worse biochemical recurrence-free survival, suggesting prognostic and therapeutic relevance."	0.8959
35228162	"Pathology, research and practice"	2022	Exosomal circ_0048856 derived from non-small cell lung cancer contributes to aggressive cancer progression through downregulation of miR-1287-5p.	hsa_circ_0048856	circ_0048856			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"Exosomal circ_0048856 is up-regulated in NSCLC serum exosomes and NSCLC cell lines. It promotes NSCLC progression by enhancing proliferation, migration, invasion and in vivo tumor growth while inhibiting apoptosis, at least partly through direct targeting and downregulation of miR-1287-5p. Serum exosomal circ_0048856 also shows diagnostic potential for NSCLC."	0.7126
35234341	Environmental toxicology	2022	A novel circular RNA confers trastuzumab resistance in human epidermal growth factor receptor 2-positive breast cancer through regulating ferroptosis.		circ-BGN	hsa_circ_BGN	BGN	HER-2 positive breast cancer	MONDO:0006244	HER2 positive breast carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circ-BGN is up-regulated in trastuzumab-resistant HER2-positive breast cancer cells and tissues and is associated with poor survival. It promotes trastuzumab resistance by directly binding OTUB1 and SLC7A11, enhancing OTUB1-mediated SLC7A11 deubiquitination and suppressing ferroptosis through the SLC7A11/GSH/GPX4 axis. circ-BGN knockdown decreases tumor cell viability, induces ferroptosis, and restores trastuzumab sensitivity, especially when combined with the ferroptosis inducer erastin."	0.8703
35238896	Biology of reproduction	2022	Circ_0007611 stimulates IL-1 receptor accessory protein to inhibit trophoblast cell proliferation and induce cell apoptosis.	hsa_circ_0007611	circ_0007611	hsa_circ_FAM193B	FAM193B	Preeclampsia / PE	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR	"In this study, circ_0007611 was significantly up-regulated in placental tissues from women with preeclampsia. Functional assays showed that circ_0007611 suppresses trophoblast proliferation and angiogenesis while promoting apoptosis. Mechanistically, circ_0007611 acts as a miR-558 sponge to increase IL1RAP expression, forming a circ_0007611/miR-558/IL1RAP regulatory pathway implicated in PE-related trophoblast dysfunction."	0.7949
35239092	Biochemical genetics	2022	Circ_0016760 Serves as a Cancer Promoter in Non-small Cell Lung Cancer Through miR-876-3p/NOVA2 Axis.	hsa_circ_0016760	circ_0016760	hsa_circ_SNAP47	SNAP47	Non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0016760 is upregulated in NSCLC tissues and cell lines, and high expression is associated with worse overall survival. Functionally, circ_0016760 promotes malignant NSCLC phenotypes including proliferation, migration, invasion, EMT, metastasis and in vivo tumor growth while suppressing apoptosis. Mechanistically, it sponges miR-876-3p to increase NOVA2 expression."	0.8174
35239093	Biochemical genetics	2022	Circ_0028007 Aggravates the Malignancy of Nasopharyngeal Carcinoma by Regulating miR-656-3p/ELF2 Axis.	hsa_circ_0028007	circ_0028007	hsa_circ_NUAK1		nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"circ_0028007 is up-regulated in NPC tissues and cells and functions as an oncogenic circRNA. Its knockdown suppresses NPC cell proliferation, migration, invasion, angiogenesis and xenograft tumor growth while promoting apoptosis. Mechanistically, circ_0028007 sponges miR-656-3p to up-regulate ELF2 and modulate the AMPK/mTOR pathway."	0.7422
35240495	International immunopharmacology	2022	Tumor promoting effect of circ_002172 associates with induced immune escape in breast cancer via the miR-296-5p/CXCL12 axis.		hsa_circ_002172			breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circ_002172 is up-regulated in breast cancer tissues and cells and functions as an oncogenic circRNA. It promotes BC cell proliferation/viability, colony formation, migration, invasion, and tumor growth by sponging miR-296-5p to increase CXCL12 expression. Through the circ_002172/miR-296-5p/CXCL12 axis, it reduces CTL infiltration and promotes immune escape, suggesting potential diagnostic or therapeutic relevance."	0.8254
35247499	Microbial pathogenesis	2022	Profile analysis of circRNAs in human THP-1 derived macrophages infected with intracellular Staphylococcus aureus.	hsa_circ_0000311				Staphylococcus aureus infection	MONDO:0005545	staphylococcus aureus infection	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0000311 was significantly up-regulated in S. aureus-infected THP-1-derived macrophages and in human serum samples from infected patients. The study suggests that it may serve as a diagnostic biomarker and constructed a predicted circRNA-miRNA-mRNA network to infer its potential regulatory role during intracellular S. aureus infection.	0.5466
35247499	Microbial pathogenesis	2022	Profile analysis of circRNAs in human THP-1 derived macrophages infected with intracellular Staphylococcus aureus.		chr13:43500472-43544806-(novel)			Staphylococcus aureus infection	MONDO:0005545	staphylococcus aureus infection	up-regulated	RT-qPCR; RNA-seq	chr13:43500472-43544806-(novel) was identified as a novel circRNA and was significantly up-regulated in S. aureus-infected THP-1-derived macrophages and in infected human serum samples. The study proposes it as a potential diagnostic biomarker and predicts that it may participate in circRNA-miRNA-mRNA regulatory interactions during intracellular S. aureus infection.	0.5466
35248826	Biochemical and biophysical research communications	2022	Circ_0000591 served as endogenous RNA for miR-326 to promote progression of cholangiocarcinoma via the TLR4/MyD88/IL6 axis.	hsa_circ_0000591	circ_0000591	hsa_circ_MGA	MGA	Cholangiocarcinoma / CCA	MONDO:0019087	cholangiocarcinoma	up-regulated	RT-qPCR	"circ_0000591 is up-regulated in cholangiocarcinoma tissues and cell lines. It promotes CCA cell proliferation, migration, invasion and in vivo tumorigenesis by sponging miR-326 and activating the TLR4/MyD88/NF-kB/IL-6 axis. Silencing circ_0000591 suppresses tumor growth and attenuates LPS-induced anti-apoptosis."	0.8275
35249038	Kidney & blood pressure research	2022	Circ_0037866 Contributes to the Tumorigenesis of Renal Cell Carcinoma by Sequestering miR-384 to Elevate Chromobox 5 Expression.	hsa_circ_0037866	circ_0037866 / circTXNDC11	hsa_circ_TXNDC11	TXNDC11	Renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR	"circ_0037866 is up-regulated in RCC tissues and cell lines and functions as an oncogenic circRNA. Its knockdown suppresses proliferation, migration, invasion, EMT and xenograft tumor growth while promoting apoptosis. Mechanistically, circ_0037866 sponges miR-384 to increase CBX5 expression, forming a circ_0037866/miR-384/CBX5 regulatory axis with potential therapeutic relevance."	0.8438
35266884	Anti-cancer drugs	2022	"Knockdown of circ_0102273 inhibits the proliferation, metastasis and glycolysis of breast cancer through miR-1236-3p/PFKFB3 axis."	hsa_circ_0102273	circ_0102273			breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0102273 is up-regulated in breast cancer tumor tissues and cell lines. It promotes breast cancer proliferation, migration, invasion, glycolysis and in vivo tumorigenesis by sponging miR-1236-3p and positively regulating PFKFB3. The study proposes the circ_0102273/miR-1236-3p/PFKFB3 axis as a potential molecular target for breast cancer treatment."	0.8298
35275449	Advances in clinical and experimental medicine : official organ Wroclaw Medical University	2022	Knockdown of circular RNA hsa_circ_0003307 inhibits synovial inflammation in ankylosing spondylitis by regulating the PI3K/AKT pathway.	hsa_circ_0003307				ankylosing spondylitis / AS	MONDO:0005306	ankylosing spondylitis	up-regulated	RT-qPCR	"hsa_circ_0003307 is up-regulated in PBMCs from AS patients and in AS-FLS. Its expression correlates with disease activity indicators and shows potential diagnostic value. Functionally, hsa_circ_0003307 promotes PI3K/AKT pathway activation and inflammatory cytokine expression, while knockdown suppresses synovial inflammation."	0.6148
35276696	Anti-cancer drugs	2022	"Circular RNA sterile alpha motif domain containing 4A contributes to cell 5-fluorouracil resistance in colorectal cancer by regulating the miR-545-3p/6-phosphofructo-2-kinase/fructose-2,6-bisphosphataseisotype 3 axis."		hsa_circ_101356 / circular RNA sterile alpha motif domain containing 4A	hsa_circ_SAMD4A	SAMD4A	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"CircSAMD4A is up-regulated in 5-Fu-resistant colorectal cancer tissues and cells and is associated with poorer 5-year overall survival. It promotes 5-Fu resistance, proliferation, glycolysis, and tumor growth while suppressing apoptosis by sponging miR-545-3p and up-regulating PFKFB3."	0.8353
35276698	Anti-cancer drugs	2022	Circ_0003146 upregulates SCARB1 expression by acting as a miR-1272 sponge to promote malignant behaviors of clear cell renal cell carcinoma.	hsa_circ_0003146	circ_0003146	hsa_circ_EHD2	EHD2	clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR	"circ_0003146 is up-regulated in ccRCC tissues and cells and functions as an oncogenic circRNA. It promotes proliferation, migration, invasion, EMT and xenograft tumor growth while suppressing apoptosis, mainly through the circ_0003146/miR-1272/SCARB1 ceRNA axis. The study suggests circ_0003146 may be a molecular target for ccRCC diagnosis and treatment."	0.786
35279605	Tissue & cell	2022	Circ_0060731 mediated miR-21-5p-PDCD4/ESR1 pathway to induce apoptosis of placental trophoblasts in intrahepatic cholestasis of pregnancy.	hsa_circ_0060731	Circ_0060731			intrahepatic cholestasis of pregnancy / ICP	MONDO:0100429	intrahepatic cholestasis of pregnancy	up-regulated	RT-qPCR	"Circ_0060731 was up-regulated in ICP placental tissues and in TCA-treated HTR8/SVneo trophoblast cells. The study proposes that Circ_0060731 acts upstream of miR-21-5p and may promote trophoblast apoptosis through the miR-21-5p-PDCD4/ESR1 axis, suggesting a potential therapeutic relevance for ICP."	0.348
35285770	Autoimmunity	2022	Hsa_circ_0037128 aggravates high glucose-induced podocytes injury in diabetic nephropathy through mediating miR-31-5p/KLF9.	hsa_circ_0037128		hsa_circ_NPRL3	NPRL3	diabetic nephropathy / DN	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"hsa_circ_0037128 is up-regulated in serum from DN patients and in high glucose-induced human podocytes. It aggravates podocyte injury by acting as a miR-31-5p sponge and increasing KLF9 expression, thereby reducing cell viability and promoting apoptosis, inflammation, and oxidative stress. The study suggests that hsa_circ_0037128 may be a therapeutic target for diabetic nephropathy."	0.8267
35286916	International immunopharmacology	2022	Hsa_circ_0087352 promotes the inflammatory response of macrophages in abdominal aortic aneurysm by adsorbing hsa-miR-149-5p.	hsa_circ_0087352		hsa_circ_UBQLN1	UBQLN1	abdominal aortic aneurysm / AAA	MONDO:0005350	abdominal aortic aneurysm	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0087352 is up-regulated in human AAA specimens and LPS-stimulated macrophages. It promotes macrophage inflammatory responses by sponging hsa-miR-149-5p, increasing IL-6 and TNF-alpha production and activating ERK/NF-kappaB signaling. Its overexpression in macrophages also promotes VSMC apoptosis, supporting its proposed value as a biomarker and therapeutic target for AAA."	0.7924
35290928	Veterinary microbiology	2022	Identification and characterization of circular RNAs in the A549 cells following Influenza A virus infection.	hsa_circ_0082633	circRNA_0082633	hsa_circ_ZC3HAV1	ZC3HAV1	Influenza A virus infection	MONDO:0005812	influenza	up-regulated	RT-qPCR; Microarray	"circRNA_0082633 is a human ZC3HAV1-derived circRNA up-regulated in A549 cells after IAV/PR8 infection. Functionally, it acts as an anti-IAV host factor by suppressing viral replication and enhancing type I IFN signaling, while its expression is at least partly induced through JAK-STAT signaling. The study also predicted potential circ_0082633-miRNA interactions, but the main experimentally supported mechanism centers on type I IFN/JAK-STAT-related antiviral response."	0.5495
35291619	Reports of biochemistry & molecular biology	2022	Potential Role of circRNA-HIPK3/microRNA-124a Crosstalk in the Pathogenesis of Rheumatoid Arthritis.	hsa_circ_0000284	Circular RNA-HIPK3 / CircHIPK3	hsa_circ_HIPK3	HIPK3	rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"This study found that circHIPK3 is significantly up-regulated in serum from RA patients across all disease activity grades. The authors propose that circHIPK3 contributes to RA pathogenesis and severity by sponging miRNA-124a, thereby associating with increased MCP-1 production and joint inflammation. circHIPK3/miRNA-124a crosstalk is suggested as a potential therapeutic target in RA."	0.4128
35300769	Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae	2022	[Effect of Circular RNA hsa_circ_0067582 on the Proliferation and Invasion Ability of Gastric Cancer Cells].	hsa_circ_0067582		hsa_circ_RASA2	RASA2	gastric cancer / GC	MONDO:0001056	gastric cancer	unknown	RT-qPCR	"This study investigated hsa_circ_0067582 in gastric cancer cell models and found that its overexpression suppresses AGS and SGC-7901 cell proliferation and invasion while promoting apoptosis. In vivo, Oe-circ_0067582 inhibited SGC-7901 xenograft tumor growth. Mechanistically, the study suggests modulation of apoptosis and EMT markers and predicts a hsa_circ_0067582-mediated ceRNA network involving hsa-miR-181b-3p, hsa-miR-337-3p, hsa-miR-421 and hsa-miR-548d-3p."	0.4648
35300972	Experimental neurology	2022	Overexpressing circ_0000831 is sufficient to inhibit neuroinflammation and vertigo in cerebral ischemia through a miR-16-5p-dependent mechanism.	mmu_circ_0000831	circ_0000831			ischemic stroke / IS	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR; RNA-seq	"circ_0000831 is down-regulated in ischemic stroke samples and MCAO mouse brain tissues. Its overexpression protects against cerebral ischemia-associated neuroinflammation, vertigo, neurological damage, and apoptosis by binding miR-16-5p and activating the AdipoR2/PPARgamma axis, with suppression of inflammatory signaling including NF-kappaB-related markers."	0.8279
35304258	Cancer letters	2022	ebv-circRPMS1 promotes the progression of EBV-associated gastric carcinoma via Sam68-dependent activation of METTL3.		ebv-circRPMS1 / circRPMS1	ebv_circ_RPMS1	RPMS1	EBV-associated gastric carcinoma / EBVaGC	MONDO:0017784	Epstein-Barr virus-associated gastric carcinoma	up-regulated	RT-qPCR; ISH	"ebv-circRPMS1 is an EBV-encoded circRNA upregulated in EBV-associated gastric carcinoma. It functions as an oncogenic circRNA by promoting proliferation, migration, invasion, tumor growth and metastasis while inhibiting apoptosis. Mechanistically, it binds Sam68 and promotes Sam68-dependent METTL3 transcription, increasing m6A-related activity; clinically, high ebv-circRPMS1 expression is linked to distant metastasis and poor overall survival."	0.8628
35305362	Research in veterinary science	2022	Differential expression of circRNAs related to lipopolysaccharide-induced inflammation in bovine mammary epithelial cells.		novel_circ_0004830			bovine mastitis	MONDO:0025100	"mastitis, bovine"	down-regulated	RT-qPCR; RNA-seq	"novel_circ_0004830 is a down-regulated bovine circRNA in LPS-stimulated MAC-T bovine mammary epithelial cells. The study suggests it may act as a ceRNA in bovine mastitis by binding inflammation-related miRNAs, including bta-miR-145."	0.5135
35305362	Research in veterinary science	2022	Differential expression of circRNAs related to lipopolysaccharide-induced inflammation in bovine mammary epithelial cells.		novel_circ_0003097			bovine mastitis	MONDO:0025100	"mastitis, bovine"	down-regulated	RNA-seq	"novel_circ_0003097 is a down-regulated bovine circRNA identified by RNA-seq in LPS-stimulated MAC-T bovine mammary epithelial cells. The study suggests it may act as a ceRNA in bovine mastitis by binding inflammation-related miRNAs, including bta-miR-145, but it was not reported as qRT-PCR-validated."	0.329
35305362	Research in veterinary science	2022	Differential expression of circRNAs related to lipopolysaccharide-induced inflammation in bovine mammary epithelial cells.		novel_circ_0005115			bovine mastitis	MONDO:0025100	"mastitis, bovine"	down-regulated	RT-qPCR; RNA-seq	"novel_circ_0005115 is a down-regulated bovine DEcircRNA in LPS-stimulated MAC-T cells, with expression verified by qRT-PCR. No individual mechanism or functional assays were reported for this circRNA."	0.3401
35305362	Research in veterinary science	2022	Differential expression of circRNAs related to lipopolysaccharide-induced inflammation in bovine mammary epithelial cells.		novel_circ_0005861			bovine mastitis	MONDO:0025100	"mastitis, bovine"	down-regulated	RT-qPCR; RNA-seq	"novel_circ_0005861 is a down-regulated bovine DEcircRNA in LPS-stimulated MAC-T cells, with expression verified by qRT-PCR. No individual mechanism or functional assays were reported for this circRNA."	0.3401
35305362	Research in veterinary science	2022	Differential expression of circRNAs related to lipopolysaccharide-induced inflammation in bovine mammary epithelial cells.		novel_circ_0004514			bovine mastitis	MONDO:0025100	"mastitis, bovine"	down-regulated	RT-qPCR; RNA-seq	"novel_circ_0004514 is a down-regulated bovine DEcircRNA in LPS-stimulated MAC-T cells, with expression verified by qRT-PCR. No individual mechanism or functional assays were reported for this circRNA."	0.3401
35305362	Research in veterinary science	2022	Differential expression of circRNAs related to lipopolysaccharide-induced inflammation in bovine mammary epithelial cells.		novel_circ_0001799			bovine mastitis	MONDO:0025100	"mastitis, bovine"	down-regulated	RT-qPCR; RNA-seq	"novel_circ_0001799 is a down-regulated bovine DEcircRNA in LPS-stimulated MAC-T cells, with expression verified by qRT-PCR. No individual mechanism or functional assays were reported for this circRNA."	0.3401
35305362	Research in veterinary science	2022	Differential expression of circRNAs related to lipopolysaccharide-induced inflammation in bovine mammary epithelial cells.		novel_circ_0001448			bovine mastitis	MONDO:0025100	"mastitis, bovine"	up-regulated	RT-qPCR; RNA-seq	"novel_circ_0001448 is an up-regulated bovine DEcircRNA in LPS-stimulated MAC-T cells, with expression verified by qRT-PCR. No individual mechanism or functional assays were reported for this circRNA."	0.3401
35305362	Research in veterinary science	2022	Differential expression of circRNAs related to lipopolysaccharide-induced inflammation in bovine mammary epithelial cells.		novel_circ_0005856			bovine mastitis	MONDO:0025100	"mastitis, bovine"	up-regulated	RT-qPCR; RNA-seq	"novel_circ_0005856 is an up-regulated bovine DEcircRNA in LPS-stimulated MAC-T cells, with expression verified by qRT-PCR. No individual mechanism or functional assays were reported for this circRNA."	0.3401
35305362	Research in veterinary science	2022	Differential expression of circRNAs related to lipopolysaccharide-induced inflammation in bovine mammary epithelial cells.		novel_circ_0001136			bovine mastitis	MONDO:0025100	"mastitis, bovine"	up-regulated	RT-qPCR; RNA-seq	"novel_circ_0001136 is an up-regulated bovine DEcircRNA in LPS-stimulated MAC-T cells, with expression verified by qRT-PCR. No individual mechanism or functional assays were reported for this circRNA."	0.3401
35305362	Research in veterinary science	2022	Differential expression of circRNAs related to lipopolysaccharide-induced inflammation in bovine mammary epithelial cells.		novel_circ_0001730			bovine mastitis	MONDO:0025100	"mastitis, bovine"	up-regulated	RT-qPCR; RNA-seq	"novel_circ_0001730 is an up-regulated bovine DEcircRNA in LPS-stimulated MAC-T cells, with expression verified by qRT-PCR. No individual mechanism or functional assays were reported for this circRNA."	0.3401
35307379	Chemico-biological interactions	2022	CircRNA_0078767 promotes osteosarcoma progression by increasing CDK14 expression through sponging microRNA-330-3p.	hsa_circ_0078767	CircRNA_0078767			osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"circ_0078767 is up-regulated in osteosarcoma tissues and cells and its high expression is associated with worse overall survival. Mechanistically, it functions as a ceRNA that sponges miR-330-3p to increase CDK14 expression, thereby promoting osteosarcoma cell proliferation, migration, invasion, tumorigenesis, and metastasis."	0.8557
35307709	Nephron	2022	Propofol Disrupts Clear Cell Renal Cell Carcinoma Tumorigenesis by Regulating circFBXW7/miR-942 Axis.	hsa_circ_0001451	circFBXW7 / circRNA F-box and WD repeat domain containing 7	hsa_circ_FBXW7	FBXW7	clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	down-regulated	RT-qPCR	"In ccRCC, circFBXW7 is down-regulated in tumor tissues and RCC cell lines, while propofol treatment increases its expression. CircFBXW7 acts as a tumor suppressor by directly targeting miR-942, inhibiting proliferation, migration and invasion and promoting apoptosis; this axis contributes to the anticancer effect of propofol in vitro and in a xenograft model."	0.7294
35316873	Zhonghua zhong liu za zhi [Chinese journal of oncology]	2022	[Mechanism of circZNF609 targeting miR-153 to regulate the proliferation and apoptosis of diffuse large B-cell lymphoma].		circZNF609	hsa_circ_ZNF609	ZNF609	diffuse large B-cell lymphoma	MONDO:0018905	diffuse large B-cell lymphoma	up-regulated	RT-qPCR	"circZNF609 is up-regulated in diffuse large B-cell lymphoma tissues. Functional knockdown experiments in OCI_LY19 cells indicate that circZNF609 promotes proliferation and cell-cycle progression and suppresses apoptosis, at least partly by targeting miR_153 and modulating C_caspase_3, p21, and cyclin D1."	0.6521
35324518	Anti-cancer drugs	2022	CircFOXK2 enhances tumorigenesis and immune evasion in non-small cell lung cancer by miR-485-5p/PD-L1 axis.		circular RNA forkhead box K2 / circFOXK2	hsa_circ_FOXK2	FOXK2	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"CircFOXK2 is up-regulated in NSCLC tissues and cells. It promotes tumorigenesis, proliferation, migration, invasion and immune evasion by sponging miR-485-5p and increasing PD-L1 expression, thereby reducing CD8+ T-cell cytotoxicity against NSCLC cells."	0.8443
35324528	Anti-cancer drugs	2022	Dexmedetomidine disrupts esophagus cancer tumorigenesis by modulating circ_0003340/miR-198/HMGA2 axis.	hsa_circ_0003340	circ_0003340			esophageal cancer	MONDO:0007576	esophageal cancer	up-regulated	RT-qPCR	"circ_0003340 is up-regulated in esophageal cancer tissues and cell lines and acts as an oncogenic circRNA. It directly targets miR-198 and regulates HMGA2, thereby promoting proliferation, invasion and tumor growth while inhibiting apoptosis. Dexmedetomidine suppresses esophageal cancer progression partly by downregulating circ_0003340 and modulating the circ_0003340/miR-198/HMGA2 axis."	0.713
35324533	Anti-cancer drugs	2022	Circ_0058063 promotes progression of thyroid cancer by sponging miR-330-3p/SDC4 axis.	hsa_circ_0058063	Circ_0058063			thyroid cancer / TC	MONDO:0002108	thyroid cancer	up-regulated	RT-qPCR	"circ_0058063 is up-regulated in thyroid cancer tissues and cell lines and acts as an oncogenic circRNA. Mechanistically, cytoplasmic circ_0058063 sponges miR-330-3p to regulate SDC4, promoting proliferation, migration/invasion and tumor growth while suppressing apoptosis. Its knockdown inhibits malignant phenotypes, suggesting circ_0058063 as a potential therapeutic target for thyroid cancer."	0.7785
35341378	The International journal of biological markers	2022	Circ_0041732 regulates tumor properties of triple-negative breast cancer cells by the miR-149-5p/FGF5 pathway.	hsa_circ_0041732	circ_0041732	hsa_circ_FAM64A	FAM64A	Triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"circ_0041732 is up-regulated in TNBC tissues and cell lines and functions as an oncogenic circRNA. Its knockdown suppresses proliferation, migration, invasion, tube formation and xenograft tumor growth while promoting apoptosis. Mechanistically, circ_0041732 sponges miR-149-5p to increase FGF5 expression, forming a circ_0041732/miR-149-5p/FGF5 regulatory axis with potential therapeutic relevance in TNBC."	0.8175
35343646	Environmental toxicology	2022	Circular RNA dehydrodolichyl diphosphate synthase facilitated triple-negative breast cancer progression via miR-362-3p/DDX5 axis.			hsa_circ_DHDDS	DHDDS	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"circDHDDS is up-regulated in TNBC tissues and cells and acts as a tumor-promoting circRNA. Mechanistically, it binds miR-362-3p to increase DDX5 expression, thereby promoting proliferation, migration, invasion, angiogenesis and tumor growth while suppressing apoptosis."	0.8443
35352613	Autoimmunity	2022	Knockdown of circ-PRKCH alleviates IL-1beta-treated chondrocyte cell phenotypic changes through modulating miR-502-5p/ADAMTS5 axis.	hsa_circ_0032131	circ-PRKCH / circRNA protein kinase C eta	hsa_circ_PRKCH	PRKCH	Osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circ-PRKCH is up-regulated in OA cartilage, OA serum exosomes, and IL-1beta-treated human chondrocytes. It promotes OA-like chondrocyte phenotypic injury through a ceRNA mechanism in which circ-PRKCH sponges miR-502-5p to increase ADAMTS5 expression, while circ-PRKCH knockdown alleviates apoptosis and inflammation and restores proliferation and migration. The study also suggests that exosomes can mediate intercellular transfer of circ-PRKCH."	0.7799
35352818	Histology and histopathology	2022	CircRNA circBACH1 facilitates hepatitis B virus replication and hepatoma development by regulating the miR-200a-3p/MAP3K2 axis.	hsa_circ_0061395	circRNA BTB domain and CNC homolog 1 (circBACH1) / circBACH1	hsa_circ_BACH1	BACH1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circBACH1 is up-regulated in HCC tissues and HBV-transfected hepatoma cells. It promotes HBV replication and hepatoma progression by sponging miR-200a-3p and increasing MAP3K2 expression, thereby enhancing proliferation, invasion, migration, metastasis and tumor growth while suppressing apoptosis. circBACH1 may represent a therapeutic target for HBV-related hepatoma."	0.7951
35353073	Journal of cardiovascular pharmacology	2022	Knockdown of circ_CDYL Contributes to Inhibit Angiotensin II-Induced Podocytes Apoptosis in Membranous Nephropathy via the miR-149-5p/TNFSF11 Pathway.	hsa_circ_0008285	circ_CDYL	hsa_circ_CDYL	CDYL	membranous nephropathy / MN	MONDO:0005376	membranous glomerulonephritis	up-regulated	RT-qPCR	"circ_CDYL is up-regulated in renal tissues and serum from MN patients and in Ang II-induced human podocytes. Functionally, circ_CDYL promotes podocyte apoptosis, while circ_CDYL knockdown protects against Ang II-induced apoptosis. Mechanistically, circ_CDYL interacts with miR-149-5p to regulate TNFSF11 expression, and serum circ_CDYL shows potential diagnostic value for MN."	0.7905
35354755	International heart journal	2022	Adipose-Derived Stem Cells-Derived Exosomes with High Amounts of Circ_0001747 Alleviate Hypoxia/Reoxygenation-Induced Injury in Myocardial Cells by Targeting MiR-199b-3p/MCL1 Axis.	mmu_circ_0001747	Circ_0001747	mmu_circ_Chordc1	Chordc1	acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	down-regulated	RT-qPCR	"Circ_0001747 is down-regulated in the mouse H/R myocardial injury model. ADSC-derived exosomes enriched with circ_0001747 alleviate H/R-induced HL-1 cell dysfunction by promoting viability and proliferation and inhibiting apoptosis and inflammation. Mechanistically, circ_0001747 sponges miR-199b-3p to increase MCL1 mRNA and protein expression."	0.7446
35357607	Molecular and cellular biochemistry	2022	Transcriptome expression profiles associated with diabetic nephropathy development.	hsa_circ_0005379	circ_0005379			diabetic nephropathy / DN	MONDO:0005016	diabetic kidney disease	down-regulated	RT-qPCR; RNA-seq	circ_0005379 was significantly downregulated in peripheral blood from macroalbuminuric DN patients compared with healthy controls and was validated by qPCR. The study proposed a predicted hsa-miR-103a-3p-circ_0005379-PTEN ceRNA relationship and suggested circ_0005379 may contribute to DN progression and serve as a biomarker.	0.4032
35357607	Molecular and cellular biochemistry	2022	Transcriptome expression profiles associated with diabetic nephropathy development.	hsa_circ_0002024	circ_0002024			diabetic nephropathy / DN	MONDO:0005016	diabetic kidney disease	down-regulated	RT-qPCR; RNA-seq	circ_0002024 was downregulated in peripheral blood in the DM versus healthy control comparison and was validated by qPCR. The study identified a predicted hsa-miR-497-5p-circ_0002024-IGF1R ceRNA relationship and proposed circ_0002024 as a potential DN biomarker.	0.4032
35357607	Molecular and cellular biochemistry	2022	Transcriptome expression profiles associated with diabetic nephropathy development.	hsa_circ_0000567	circ_0000567			diabetic nephropathy / DN	MONDO:0005016	diabetic kidney disease	down-regulated	RT-qPCR; RNA-seq	circ_0000567 was significantly downregulated in peripheral blood from macroalbuminuric DN patients compared with healthy controls and was validated by qPCR. The study proposed a predicted hsa-miR-1269a-circ_0000567-SOX6 ceRNA relationship and suggested circ_0000567 may contribute to DN incidence and progression.	0.4032
35357607	Molecular and cellular biochemistry	2022	Transcriptome expression profiles associated with diabetic nephropathy development.	hsa_circ_0001098	circ_0001098			diabetic nephropathy / DN	MONDO:0005016	diabetic kidney disease	dysregulated	RNA-seq	"circ_0001098 was included among differentially expressed circRNAs used to construct a predicted DN-associated ceRNA network. Its proposed network relationship was hsa-miR-181b-5p-circ_0001098-XIAP, but no qPCR validation or functional experiment was reported for this circRNA."	0.1768
35357607	Molecular and cellular biochemistry	2022	Transcriptome expression profiles associated with diabetic nephropathy development.	hsa_circ_0008193	circ_0008193			diabetic nephropathy / DN	MONDO:0005016	diabetic kidney disease	dysregulated	RNA-seq	"circ_0008193 was included among differentially expressed circRNAs used to construct a predicted DN-associated ceRNA network. Its proposed network relationship was hsa-miR-24-3p-circ_0008193-TRIB3, but no qPCR validation or functional experiment was reported for this circRNA."	0.1768
35357607	Molecular and cellular biochemistry	2022	Transcriptome expression profiles associated with diabetic nephropathy development.	hsa_circ_0005870	circ_0005870			diabetic nephropathy / DN	MONDO:0005016	diabetic kidney disease	dysregulated	RNA-seq	"circ_0005870 was included among differentially expressed circRNAs used to construct a predicted DN-associated ceRNA network. Its proposed network relationship was hsa-miR-328-5p-circ_0005870-CD44, but no qPCR validation or functional experiment was reported for this circRNA."	0.1768
35357607	Molecular and cellular biochemistry	2022	Transcriptome expression profiles associated with diabetic nephropathy development.	hsa_circ_0000069	circ_0000069			diabetic nephropathy / DN	MONDO:0005016	diabetic kidney disease	dysregulated	RNA-seq	"circ_0000069 was included among differentially expressed circRNAs used to construct a predicted DN-associated ceRNA network. Its proposed network relationship was hsa-miR-15b-5p-circ_0000069-SMAD2, but no qPCR validation or functional experiment was reported for this circRNA."	0.1768
35358781	"Pathology, research and practice"	2022	circ0125803 facilitates tumor progression by sponging miR-197-5p and upregulating E2F1 in neuroblastoma.	hsa_circ_0125803	circ0125803			neuroblastoma	MONDO:0005072	neuroblastoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0125803/circ0125803 is up-regulated in neuroblastoma tissues and neuroblastoma cell lines. It promotes neuroblastoma proliferation, migration, invasion/metastasis and progression by acting as a cytoplasmic miR-197-5p sponge and increasing E2F1 expression, suggesting potential therapeutic relevance."	0.8195
35365990	Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology	2022	[Overexpression of circ_LARP4 inhibits the proliferation and migration of MCF-7 human breast cancer cells and its mechanism].		circ£ÒNA La-associated protein 4 / circ_LA£ÒP4	hsa_circ_LARP4		breast cancer / BC	MONDO:0007254	breast cancer	unknown	RT-qPCR	"This study investigated circ_LA£ÒP4 in MCF-7 human breast cancer cells using an overexpression model. circ_LA£ÒP4 overexpression inhibited proliferation, invasion/migration-related behavior and stem cell-like characteristics, while reducing iNOS and IL-1beta levels. Mechanistically, the study links these effects to altered expression of ki67, p21, OCT4, SOX2, VEGF, N-cadherin and E-cadherin."	0.421
35382622	Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists	2022	Hsa_circ_0030042 Facilitates the Proliferation and Migration of Vascular Smooth Muscle Cells via the miR-514a-3p/FOXO1 Axis.	hsa_circ_0030042		hsa_circ_FOXO1		atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"hsa_circ_0030042 is up-regulated in TNF-alpha- or IL-6-induced human VSMCs used as an atherosclerosis cell model. It promotes VSMC proliferation and migration while inhibiting apoptosis, mainly through sponging miR-514a-3p to up-regulate FOXO1 and additionally modulating the NF-kB pathway via P65 translocation."	0.8095
35384084	Molecular carcinogenesis	2022	"CircTCF25 serves as a sponge for miR-206 to support proliferation, migration, and invasion of glioma via the Jak2/p-Stat3/CypB axis."	hsa_circ_0041103	circTCF25 / circular RNA TCF25	hsa_circ_TCF25	TCF25	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; Microarray	"circTCF25/hsa_circ_0041103 is up-regulated in glioma and high expression is associated with advanced grade and poor overall survival. Mechanistically, it functions as a cytoplasmic miR-206 sponge to increase CypB expression and activate the JAK2/p-STAT3 signaling pathway, thereby promoting glioma proliferation, migration, invasion, metastasis and tumorigenesis."	0.784
35384910	Journal of cardiovascular pharmacology	2022	CircLDLR Modulates the Proliferation and Apoptosis of Vascular Smooth Muscle Cells in Coronary Artery Disease Through miR-26-5p/KDM6A Axis.		circLDLR	hsa_circ_LDLR	LDLR	coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	down-regulated	RT-qPCR	"circLDLR is significantly down-regulated in CAD tissues. Functionally, circLDLR overexpression suppresses VSMC proliferation and promotes apoptosis, at least partly through modulation of the miR-26-5p/KDM6A axis, suggesting therapeutic relevance for CAD."	0.6479
35384929	Journal of lower genital tract disease	2022	High Expression of Circular RNA-Mitochondrial tRNA Translation Optimization 1 Assists the Diagnosis of High-Risk Human Papillomavirus Infection in Cervical Cancer.		circular RNA-mitochondrial tRNA translation optimization 1 / circMTO1	hsa_circ_MTO1	MTO1	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"This study found that serum circMTO1 is upregulated in cervical cancer and further elevated in HR-HPV-positive cervical cancer. Its serum level showed diagnostic value for CC and HR-HPV-positive CC and was associated with adverse clinicopathological features and higher HR-HPV infection risk. Mechanistically, circMTO1 was predicted and experimentally validated to bind miR-199a, suggesting a potential circMTO1/miR-199a ceRNA relationship in HR-HPV-positive CC."	0.559
35386035	Metabolic brain disease	2022	Sevoflurane inhibits the malignant phenotypes of glioma through regulating miR-146b-5p/NFIB axis.	hsa_circ_0129854	circ_VCAN	hsa_circ_VCAN	VCAN	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ_VCAN is upregulated in glioma tissues and is downregulated by sevoflurane treatment in glioma cells. Functionally, circ_VCAN overexpression counteracts sevoflurane-mediated inhibition of proliferation, migration, invasion and tumor growth, while reducing sevoflurane-induced apoptosis. Mechanistically, circ_VCAN sponges miR-146b-5p to upregulate NFIB, forming a circ_VCAN/miR-146b-5p/NFIB axis in glioma."	0.7861
35389936	Anti-cancer drugs	2022	Circ_0009035 regulates the progression of cervical cancer by targeting miR-1305/CREBRF axis.	hsa_circ_0009035	circ_0009035 / circRACGAP1	hsa_circ_RACGAP1	RACGAP1	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ_0009035/circRACGAP1 is upregulated in cervical cancer tissues and cell lines and is mainly localized in the cytoplasm. Functional knockdown experiments indicate that it promotes proliferation, migration, invasion, angiogenesis, EMT and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ_0009035 targets miR-1305 to regulate CREBRF expression, forming a circ_0009035/miR-1305/CREBRF axis in cervical cancer progression."	0.8175
35397427	Biochemical and biophysical research communications	2022	Administration of circRNA_0075932 shRNA exhibits a therapeutic effect on burn-associated infection in obese rats.	rno_circ_0075932	circRNA_0075932			burn-associated infection	MONDO:0000001	disease	up-regulated	RT-qPCR	circRNA_0075932 is upregulated in burn-associated infection in obese rats and burned skin of obese individuals. The study suggests it promotes inflammatory signaling via miR-142/miR-495-mediated regulation of NLRP3 and PUM2 and activation of NF-kB-related responses. Knockdown via shRNA/exosome delivery alleviated inflammatory dysregulation and showed a therapeutic effect.	0.5223
35410505	"Experimental biology and medicine (Maywood, N.J.)"	2022	Identification of a circRNA-mediated comprehensive ceRNA network in spinal cord injury pathogenesis.	hsa_circ_0026646				spinal cord injury / SCI	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR; Microarray	"This study identified hsa_circ_0026646 as a core up-regulated circRNA in spinal cord injury. It may function as a ceRNA by sponging miR-331-3p and regulating PLXNB2, forming the hsa_circ_0026646/miR-331-3p/PLXNB2 axis. The authors suggest that this axis may regulate immune-related SCI pathogenesis and provide potential therapeutic targets."	0.4851
35413598	"Pathology, research and practice"	2022	Circular RNA circ_0051620 sponges miR-338-3p and regulates ADAM17 to promote the gastric cancer progression.	hsa_circ_0051620	circ_0051620	hsa_circ_SLC1A5	SLC1A5	gastric cancer / GC	MONDO:0004950	gastric carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"circ_0051620 is up-regulated in gastric cancer tissues and cell lines and its high expression is associated with TNM stage and poor prognosis. Functionally, circ_0051620 promotes GC cell proliferation, migration and invasion by sponging miR-338-3p and increasing ADAM17 expression, suggesting the circ_0051620/miR-338-3p/ADAM17 axis as a potential therapeutic target."	0.7566
35413678	International immunopharmacology	2022	Circ_0050908 up-regulates TRAF3 by sponging miR-324-5p to aggravate myocardial ischemia-reperfusion injury.	hsa_circ_0050908	circ_0050908	hsa_circ_ACTN4	ACTN4	myocardial ischemia/reperfusion injury	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR	"Circ_0050908 is up-regulated in human cardiomyocytes under simulated myocardial I/R injury. It aggravates I/R-induced cardiomyocyte injury by sponging miR-324-5p and thereby increasing TRAF3, promoting apoptosis, inflammation, and oxidative stress. Knockdown of circ_0050908 shows a protective effect in the in vitro I/R model."	0.7812
35426617	Biochemical genetics	2022	CircTMEM59 Serves as miR-410-3p Sponge to Inhibit the Proliferation and Metastasis of Colorectal Cancer by Regulating HOXD8.	hsa_circ_0012634	circTMEM59	hsa_circ_TMEM59	TMEM59	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	"circTMEM59 (hsa_circ_0012634), derived from TMEM59, is down-regulated in CRC tissues and cells. It functions as a tumor suppressor by sponging miR-410-3p to increase HOXD8 expression, thereby inhibiting CRC proliferation, migration, invasion, metastasis and xenograft tumor growth. Its reduced expression is associated with higher tumor stage, suggesting potential therapeutic relevance."	0.7944
35439323	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2022	CircRNA hsa_circ_0071336 is associated with type 2 diabetes through targeting the miR-93-5p/GLUT4 axis.	hsa_circ_0071336	circ_0071336			Type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	down-regulated	RT-qPCR; Microarray	"hsa_circ_0071336 is downregulated in blood/PBMCs and adipose tissues in T2D and is proposed as a diagnostic biomarker for T2D and IFG. Mechanistically, it directly binds miR-93-5p and regulates GLUT4 expression through a circRNA-miRNA-mRNA ceRNA axis, linking reduced hsa_circ_0071336 expression to insulin resistance and T2D pathogenesis."	0.7039
35460835	Cellular signalling	2022	Breast cancer derived exosomes promoted angiogenesis of endothelial cells in microenvironment via circHIPK3/miR-124-3p/MTDH axis.		circHIPK3	hsa_circ_HIPK3	HIPK3	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"In this study, breast cancer cell-derived exosomal circHIPK3 was upregulated and could be transferred to endothelial cells. It promoted endothelial cell proliferation, tube formation, angiogenesis, and tumor growth by sponging miR-124-3p and increasing MTDH expression, suggesting potential value as an anti-angiogenesis therapeutic target in breast cancer."	0.7799
35477026	"Clinical immunology (Orlando, Fla.)"	2022	Circ_NNT suppresses the apoptosis and inflammation in glucose-induced human retinal pigment epithelium by regulating miR-320b/TIMP3 axis in diabetic retinopathy.	hsa_circ_0072410	circ_NNT / CircRNA nicotinamide nucleotide transhydrogenase	hsa_circ_NNT	NNT	diabetic retinopathy / DR	MONDO:0005266	diabetic retinopathy	down-regulated	RT-qPCR	"circ_NNT is down-regulated in high glucose-challenged ARPE-19 cells, an in vitro model used to study diabetic retinopathy. Its overexpression protects retinal pigment epithelial cells by promoting proliferation and suppressing apoptosis and inflammatory cytokine production through the circ_NNT/miR-320b/TIMP3 regulatory axis."	0.7626
35482130	Biochemical genetics	2022	Hsa_circ_0010729 is Involved in Oxygen-Glucose Deprivation/Reoxygenation-Induced Human Microvascular Endothelial Cell Deprivation by Targeting miR-665/ING5.	hsa_circ_0010729	Circular RNA_0010729	hsa_circ_HSPG2	HSPG2	ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR	"This study found that hsa_circ_0010729 is up-regulated in OGD/R-induced human brain microvascular endothelial cells. Functionally, hsa_circ_0010729 knockdown protects HBMECs from OGD/R-induced injury by enhancing proliferation and reducing apoptosis, inflammatory cytokine production, LDH release, and oxidative stress. Mechanistically, hsa_circ_0010729 acts as a sponge for miR-665 to positively regulate ING5, forming a hsa_circ_0010729/miR-665/ING5 axis relevant to ischemic stroke injury."	0.7615
35484432	Cell biology and toxicology	2023	hMSCs-derived exosome circCDK13 inhibits liver fibrosis by regulating the expression of MFGE8 through miR-17-5p/KAT2B.		circCDK13	hsa_circ_CDK13	CDK13	liver fibrosis	MONDO:0005155	cirrhosis of liver	unknown	RT-qPCR	"This study shows that hMSC-derived exosomal circCDK13 suppresses liver fibrosis by inhibiting HSC activation and proliferation. Mechanistically, circCDK13 sponges miR-17-5p to regulate KAT2B, promoting MFGE8 transcription via H3 acetylation and inhibiting PI3K/AKT and NF-kappaB signaling."	0.8075
35484754	Journal of biomedical nanotechnology	2022	Mechanism for Bioactive Nanomaterial circ0024831 Regulation of Staphylococcal Nuclease Domain Containing 1 via RNA Methylation Recognition in Osteosarcoma.		circ0024831	hsa_circ_ETS1	ETS1	osteosarcoma / OS	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; RNA-seq	"circ0024831 is down-regulated in osteosarcoma and acts as a suppressive circRNA. It binds SND1 in the cytoplasm through the Tudor-domain-related interaction, interferes with SND1 recognition of M6A-modified RNA, decreases downstream mRNA stability and c-myb/STAT6 expression, and inhibits osteosarcoma cell proliferation and invasion."	0.7283
35484754	Journal of biomedical nanotechnology	2022	Mechanism for Bioactive Nanomaterial circ0024831 Regulation of Staphylococcal Nuclease Domain Containing 1 via RNA Methylation Recognition in Osteosarcoma.	hsa_circ_0032279	circ0032279			osteosarcoma / OS	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; RNA-seq	"circ0032279 was identified as a down-regulated circRNA in osteosarcoma by RT-PCR validation after screening. Unlike circ0024831, it did not show significant SND1-associated RIP pull-down changes, and the study did not establish a functional or mechanistic role for circ0032279 in osteosarcoma."	0.4685
35490654	"Pathology, research and practice"	2022	Upregulation of circ_0059961 suppresses cholangiocarcinoma development by modulating miR-629-5p/SFRP2 axis.	hsa_circ_0059961	circ_0059961	hsa_circ_ITCH	ITCH	cholangiocarcinoma / CCA	MONDO:0019087	cholangiocarcinoma	down-regulated	RT-qPCR	"Circ_0059961 is down-regulated in cholangiocarcinoma tissues and cells and functions as a tumor-suppressive circRNA. Its overexpression suppresses proliferation, migration, invasion, EMT-associated changes and xenograft tumor growth while promoting apoptosis, mainly through the circ_0059961/miR-629-5p/SFRP2 ceRNA axis. Clinically, low circ_0059961 expression is associated with advanced TNM stage, lymph node invasion and worse overall survival."	0.7887
35506422	Histology and histopathology	2022	Circular RNA circSDHC (hsa_circ_0015004) regulates tumor growth and angiogenesis via regulating centrosomal protein 55 expression in renal cell carcinoma.	hsa_circ_0015004	circSDHC / CircRNA-SDHC	hsa_circ_SDHC	SDHC	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR	"circSDHC is up-regulated in RCC tissues and cell lines and is mainly localized in the cytoplasm. It promotes RCC tumor growth, proliferation, angiogenesis, migration and invasion while suppressing apoptosis. Mechanistically, circSDHC acts as a miR-130a-3p sponge to increase CEP55 expression, supporting the circSDHC/miR-130a-3p/CEP55 regulatory axis as a potential therapeutic target in RCC."	0.7373
35521898	Histology and histopathology	2022	Anesthetic propofol suppresses growth and metastasis of lung adenocarcinoma in vitro through downregulating circ-MEMO1-miR-485-3p-NEK4 ceRNA axis.	hsa_circ_0007385	circRNA-Mediator of cell motility 1 / circ-MEMO1	hsa_circ_MEMO1	MEMO1	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"circ-MEMO1 is up-regulated in LUAD tissues and LUAD cell lines and high expression is linked to poorer overall survival. In vitro, circ-MEMO1 overexpression counteracts propofol-induced suppression of LUAD cell growth, migration and invasion by sponging miR-485-3p and regulating NEK4 within a ceRNA axis."	0.7126
35523104	"Pathology, research and practice"	2022	circSPECC1 promotes bladder cancer progression via regulating miR-136-5p/GNAS axis.	hsa_circ_0000745	circSPECC1 / circ_0000745	hsa_circ_SPECC1	SPECC1	bladder cancer / Bca	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circSPECC1/circ_0000745 is a SPECC1-derived circRNA that is up-regulated in bladder cancer tissues and cell lines. It functions as an oncogenic cytoplasmic ceRNA by sponging miR-136-5p, thereby increasing GNAS expression and promoting bladder cancer proliferation, migration, and in vivo tumor growth. High circSPECC1 expression is associated with larger tumor size and shorter overall survival."	0.817
35532261	Human & experimental toxicology	2022	Icariin inhibits gastric cancer cell growth by regulating the hsa_circ_0003159/miR-223-3p/NLRP3 signaling axis.	hsa_circ_0003159			CACNA2D1	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"hsa_circ_0003159 is downregulated in gastric cancer and acts as a tumor-suppressive circRNA in this study context. It sponges miR-223-3p to upregulate NLRP3, thereby affecting cell viability and pyroptosis; icariin exerts anti-gastric-cancer effects partly through this axis."	0.6207
35532376	"Clinical science (London, England : 1979)"	2022	CircUSP36 attenuates ischemic stroke injury through the miR-139-3p/SMAD3/Bcl2 signal axis.	hsa_circ_0045932	circUSP36	hsa_circ_USP36	USP36	ischemic stroke / IS	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR	"circUSP36 is down-regulated in peripheral blood from ischemic stroke patients and lower expression is associated with disease severity, infarct volume, and poor prognosis. Functionally, circUSP36 protects against ischemic injury by promoting astrocyte survival and inhibiting apoptosis through the miR-139-3p/SMAD3/Bcl2 axis, and its overexpression reduces infarct volume and neurological deficits in a tMCAO mouse model."	0.8814
35533615	Reproductive biology	2022	Hsa_circ_0001495 contributes to cervical cancer progression by targeting miR-526b-3p/TMBIM6/mTOR axis.	hsa_circ_0001495	circCCNB1	hsa_circ_CCNB1	CCNB1	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"Hsa_circ_0001495 is up-regulated in cervical cancer tissues and cell lines. It promotes glycolysis, proliferation, migration, invasion and xenograft tumor growth while inhibiting apoptosis, mainly by sponging miR-526b-3p to regulate TMBIM6 and mTOR phosphorylation. The study proposes hsa_circ_0001495 as a potential diagnostic/prognostic marker and therapeutic target in cervical cancer."	0.8299
35535987	Histology and histopathology	2023	"CircKCNQ5 controls proliferation, migration, invasion, apoptosis, and glycolysis of multiple myeloma cells by modulating miR-335-5p/BRD4 axis."	hsa_circ_0007165	CircKCNQ5	hsa_circ_KCNQ5	KCNQ5	multiple myeloma / MM	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR	"circKCNQ5 is up-regulated in multiple myeloma tissues and cells, and high expression is associated with poorer OS/PFS and advanced ISS stage. Functionally, circKCNQ5 promotes MM cell proliferation, migration, invasion, glycolysis and EMT-related changes while suppressing apoptosis. Mechanistically, it acts as a miR-335-5p sponge to increase BRD4 expression."	0.8198
35543246	Histology and histopathology	2022	Knockdown of circRNA circEBF1 inhibits cutaneous squamous cell carcinoma progression by regulating the miR-1247-5p/CSF3 axis.	hsa_circ_0074817	circRNA EBF transcription factor 1 (circEBF1) / CircEBF1	hsa_circ_EBF1	EBF1	cutaneous squamous cell carcinoma / CSCC	MONDO:0002529	skin squamous cell carcinoma	up-regulated	RT-qPCR	"circEBF1 is up-regulated in CSCC tissues and cell lines. Functionally, circEBF1 promotes CSCC cell proliferation, migration, invasion, glycolysis and xenograft tumor growth while suppressing apoptosis. Mechanistically, circEBF1 acts as a ceRNA for miR-1247-5p to increase CSF3 expression, forming a circEBF1/miR-1247-5p/CSF3 axis that facilitates CSCC progression."	0.8439
35545337	Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences	2022	Construction of endogenous RNA regulatory network for colorectal cancer based on bioinformatics.	hsa_circ_0065173		hsa_circ_SETD2	SETD2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_0065173/hsa_circ_0065173 is a human circRNA derived from SETD2 that is significantly down-regulated in CRC tissues. The study proposes that it may function through a ceRNA network involving hsa-mir-450b and hsa-mir-582 to regulate ADCY5, CHRM2, CNR1 and LPAR1, suggesting potential relevance to CRC mechanisms and therapeutic targets."	0.4032
35545337	Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences	2022	Construction of endogenous RNA regulatory network for colorectal cancer based on bioinformatics.	hsa_circ_0062682		hsa_circ_TPST2	TPST2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	dysregulated	Microarray	"hsa_circRNA_103188/hsa_circ_0062682 is a human TPST2-derived circRNA identified as differentially expressed in CRC microarray datasets. It was among the eight CSCD-confirmed circRNAs taken forward for bioinformatics analysis, but no circRNA-specific experimental validation or functional mechanism was reported."	0.1768
35545337	Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences	2022	Construction of endogenous RNA regulatory network for colorectal cancer based on bioinformatics.	hsa_circ_0006332		hsa_circ_MYBL2	MYBL2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	dysregulated	Microarray	hsa_circRNA_103066/hsa_circ_0006332 is a human MYBL2-derived circRNA found as a differential circRNA in CRC dataset analysis and confirmed in CSCD. This article did not provide individual RT-qPCR validation or a specific experimentally validated CRC mechanism for this circRNA.	0.1768
35545337	Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences	2022	Construction of endogenous RNA regulatory network for colorectal cancer based on bioinformatics.	hsa_circ_0001535		hsa_circ_FAM13B	FAM13B	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	dysregulated	Microarray	hsa_circRNA_103951/hsa_circ_0001535 is a human FAM13B-derived circRNA identified as dysregulated in CRC microarray datasets and included in CSCD-confirmed downstream bioinformatics analysis. No individual RT-qPCR validation or mechanistic experiment was reported for this circRNA.	0.1768
35545535	Endocrine journal	2022	Circ_FOXP1 promotes the growth and survival of high glucose-treated human trophoblast cells through the regulation of miR-508-3p/SMAD family member 2 pathway.	hsa_circ_0008234	circ_FOXP1 / Circ_0008234	hsa_circ_FOXP1	FOXP1	Gestational diabetes mellitus / GDM	MONDO:0005406	gestational diabetes	down-regulated	RT-qPCR	"Circ_FOXP1 is downregulated in GDM serum samples and high glucose-treated HTR-8/SVneo trophoblast cells. Its overexpression protects trophoblast cells from HG-induced injury by promoting proliferation and cell cycle progression while inhibiting apoptosis. Mechanistically, circ_FOXP1 targets miR-508-3p to relieve repression of SMAD2, forming a circ_FOXP1/miR-508-3p/SMAD2 regulatory axis."	0.8119
35552087	"Pathology, research and practice"	2022	Circ_0000514 promotes the malignant biological behaviors of non-small cell lung cancer cells by modulating miR-330-5p and HMGA2.	hsa_circ_0000514	Circular RNA 0000514	hsa_circ_RPPH1	RPPH1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"Circ_0000514 is an up-regulated oncogenic circRNA in NSCLC. It promotes malignant phenotypes including proliferation, cell cycle progression, migration and invasion while suppressing apoptosis, mainly through sponging miR-330-5p and up-regulating HMGA2. Its high expression is associated with advanced TNM stage and adverse clinicopathological indicators."	0.78
35557573	Journal of gastrointestinal oncology	2022	A microarray expression profile and bioinformatic analysis of circular RNA in human esophageal carcinoma.	hsa_circ_0108310	hsa_circRNA_401955	hsa_circ_DTNA	DTNA	esophageal cancer	MONDO:0007576	esophageal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_401955 is an up-regulated exonic circRNA in EC tumor tissues and was identified as the most connected hub circRNA. The study predicts that it may participate in a circRNA-miRNA-mRNA regulatory network involving five miRNAs and pathways related to mRNA surveillance, actin cytoskeleton regulation, spliceosome, and NOD-like receptor signaling, supporting its potential value as an EC biomarker or therapeutic target."	0.5135
35557573	Journal of gastrointestinal oncology	2022	A microarray expression profile and bioinformatic analysis of circular RNA in human esophageal carcinoma.	hsa_circ_0006758	hsa_circRNA_100375	hsa_circ_UCK2	UCK2	esophageal cancer	MONDO:0007576	esophageal cancer	up-regulated	RT-qPCR; Microarray	"hsa_circRNA_100375 is an up-regulated exonic circRNA in EC tumor tissues and was experimentally validated by RT-PCR. The study predicts that it participates in a cancer-related circRNA-miRNA axis with hsa-miR-324-3p, hsa-miR-29a-5p, hsa-miR-485-3p, and hsa-miR-149-5p, with downstream pathway-associated proteins including FGFR1, PTGER2, WNT9B, WNT2B, SP1, CREBBP, IL-6, and DVL2, suggesting potential biomarker and therapeutic target value."	0.5135
35561648	"Pathology, research and practice"	2022	"Circ_0000775 promotes the migration, invasion and EMT of hepatic carcinoma cells by recruiting IGF2BP2 to stabilize CDC27."	hsa_circ_0000775	circ_0000775	hsa_circ_KIF18B	KIF18B	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0000775 is an up-regulated KIF18B-derived circRNA in hepatic carcinoma models. TCF7L2 activates its transcription, and cytoplasmic circ_0000775 recruits the RBP IGF2BP2 to stabilize CDC27 mRNA via m6A-related regulation, thereby promoting HC cell migration, invasion and EMT."	0.813
35569717	Transplant immunology	2022	Circ_0000274 contributes to renal cell carcinoma progression by regulating miR-338-3p/NUCB2 axis and JAK1/STAT3 pathway.	hsa_circ_0000274	circRNA nucleoporin 98 (circNUP98)	hsa_circ_NUP98	NUP98	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR	"circ_0000274 is up-regulated in RCC tissues and cells and acts as an oncogenic circRNA. It promotes RCC growth, migration, invasion, angiogenesis and in vivo tumor formation while suppressing apoptosis through the miR-338-3p/NUCB2 axis and activation of JAK1/STAT3 signaling. Its higher expression is associated with advanced TNM stage and metastasis."	0.8006
35570481	Clinical hemorheology and microcirculation	2022	Circ_0124644 enhances ox-LDL-induced cell damages in human umbilical vein endothelial cells through upregulating FOXO4 by sponging miR-370-3p.	hsa_circ_0124644	Circ_0124644			atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"circ 0124644 is up-regulated in AS serum samples and ox-LDL-treated HUVECs. It aggravates ox-LDL-induced endothelial injury by sponging miR-370-3p and increasing FOXO4 expression, thereby suppressing endothelial cell growth and angiogenesis while promoting apoptosis and inflammation."	0.705
35576907	Gerontology	2022	Mechanism of circHIPK3-miRNA-124-3p/miRNA-148b-3p-Mediated Inflammatory Responses and Cell Senescence in Candida albicans-Induced Septic Acute Kidney Injury.		circRNA homeodomain-interacting protein kinase 3 / circHIPK3	hsa_circ_HIPK3	HIPK3	septic acute kidney injury	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in SAKI patient serum, SAKI mouse kidney tissues, and LPS-induced HK-2 cells. It aggravates SAKI inflammation through the miR-124-3p/KLF6/NLRP3/caspase-1 pyroptosis pathway and accelerates cell senescence through the miR-148b-3p/DNMT1/3a/Klotho promoter methylation axis. Silencing circHIPK3 protects against kidney injury, reduces inflammatory responses and senescence, and improves HK-2 cell viability."	0.8081
35576990	Experimental neurology	2022	circHIPK3 regulates apoptosis and mitochondrial dysfunction induced by ischemic stroke in mice by sponging miR-148b-3p via CDK5R1/SIRT1.		circRNA homeodomain-interacting protein kinase 3 / circHIPK3	mmu_circ_HIPK3	HIPK3	ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR; RNA-seq	"This study identified circHIPK3 as an up-regulated circRNA in ischemic brain tissues of tMCAO-induced stroke model mice. circHIPK3 promotes ischemic injury, BMEC apoptosis, and mitochondrial dysfunction by sponging miR-148b-3p, increasing CDK5R1/CDK5 signaling, and suppressing SIRT1. Knockdown of circHIPK3 alleviated cerebral I/R injury, supporting circHIPK3 as a potential therapeutic target for ischemic stroke."	0.7977
35580441	Phytomedicine : international journal of phytotherapy and phytopharmacology	2022	Eriodictyol inhibits breast carcinogenesis by targeting circ_0007503 and repressing PI3K/Akt pathway.	hsa_circ_0007503	circ_0007503			breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0007503 is up-regulated during breast carcinogenesis and is downregulated by eriodictyol in breast cancer cells, carcinogen-transformed MCF10A cells, and rat mammary tumors. Functional rescue by circ_0007503 overexpression reduces eriodictyol-induced cytotoxicity and weakens repression of the PI3K/Akt pathway, suggesting that circ_0007503 supports breast carcinogenesis-associated signaling and modulates eriodictyol response."	0.4236
35580464	The Journal of surgical research	2022	Circ_0003423 Alleviates Oxidized Low-Density Lipoprotein-Induced Endothelial Cell Injury by Sponging miR-142-3p and Activating Sirtuin 3/Superoxide Dismutase 2 Pathway.	hsa_circ_0003423	Circ_0003423	hsa_circ_ZNF532	ZNF532	atherosclerosis / AS	MONDO:0005311	atherosclerosis	down-regulated	RT-qPCR	"Circ_0,003,423 was down-regulated in ox-LDL-induced HUVECs used as an in vitro atherosclerosis model. Its overexpression alleviated endothelial cell injury by promoting proliferation, migration and angiogenesis, suppressing apoptosis and oxidative stress, and regulating the miR-142-3p/SIRT3/SOD2 axis."	0.741
35593126	American journal of rhinology & allergy	2022	"CircKIAA0368 Promotes Proliferation, Migration, and Invasion by Upregulating HOXA10 in Nasopharyngeal Carcinoma."	hsa_circ_0088018	circKIAA0368	hsa_circ_KIAA0368	KIAA0368	Nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"circKIAA0368 is upregulated in NPC cells and promotes malignant phenotypes including proliferation, migration, invasion, EMT, and xenograft tumor growth. Mechanistically, it increases HOXA10 expression through a miR-6838-5p/HOXA10 ceRNA mechanism and by binding PCAF to reduce HOXA10 acetylation and degradation."	0.8341
35593126	American journal of rhinology & allergy	2022	"CircKIAA0368 Promotes Proliferation, Migration, and Invasion by Upregulating HOXA10 in Nasopharyngeal Carcinoma."	hsa_circ_0093674				Nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"hsa_circ_0093674 was identified by RT-qPCR as significantly upregulated in NPC cells compared with normal NP-69 cells. Its knockdown did not significantly change HOXA10 protein levels, and no further disease mechanism or functional role was established in this study."	0.3513
35593126	American journal of rhinology & allergy	2022	"CircKIAA0368 Promotes Proliferation, Migration, and Invasion by Upregulating HOXA10 in Nasopharyngeal Carcinoma."	hsa_circ_0081534				Nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"hsa_circ_0081534 was identified by RT-qPCR as significantly upregulated in NPC cells compared with normal NP-69 cells. Its knockdown did not significantly change HOXA10 protein levels, and no further disease mechanism or functional role was established in this study."	0.3513
35593126	American journal of rhinology & allergy	2022	"CircKIAA0368 Promotes Proliferation, Migration, and Invasion by Upregulating HOXA10 in Nasopharyngeal Carcinoma."	hsa_circ_0079557				Nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"hsa_circ_0079557 was identified by RT-qPCR as significantly upregulated in NPC cells compared with normal NP-69 cells. Its knockdown did not significantly change HOXA10 protein levels, and no further disease mechanism or functional role was established in this study."	0.3513
35605724	Chemosphere	2022	"The involvement of copper, circular RNAs, and inflammatory cytokines in chronic respiratory disease."	hsa_circ_0008882	circ_0008882			chronic respiratory diseases / CRDs	MONDO:0005087	respiratory system disorder	down-regulated	RT-qPCR; Microarray	"circ_0008882 is down-regulated in CRD and after copper exposure. It inhibits copper-induced inflammatory cytokine expression, particularly IL-6 and IL-8, in human bronchial epithelial cells and may serve as a biomarker for CRD or copper exposure."	0.6336
35605724	Chemosphere	2022	"The involvement of copper, circular RNAs, and inflammatory cytokines in chronic respiratory disease."	hsa_circ_0022279	circ_0022279			chronic respiratory diseases / CRDs	MONDO:0005087	respiratory system disorder	down-regulated	RT-qPCR; Microarray	circ_0022279 was identified as a CRD-related plasma circRNA. Its expression was lower in CRD patients and it was statistically associated with CRD risk.	0.3588
35605724	Chemosphere	2022	"The involvement of copper, circular RNAs, and inflammatory cytokines in chronic respiratory disease."	hsa_circ_0022287	circ_0022287			chronic respiratory diseases / CRDs	MONDO:0005087	respiratory system disorder	dysregulated	RT-qPCR; Microarray	circ_0022287 was identified among nine plasma circRNAs significantly associated with CRD risk. No specific mechanistic function was experimentally characterized for this circRNA.	0.3588
35605724	Chemosphere	2022	"The involvement of copper, circular RNAs, and inflammatory cytokines in chronic respiratory disease."	hsa_circ_0010050	circ_0010050			chronic respiratory diseases / CRDs	MONDO:0005087	respiratory system disorder	dysregulated	RT-qPCR; Microarray	"circ_0010050 was identified as one of nine CRD-related circRNAs in plasma. It showed a significant statistical association with CRD risk, but no specific biological mechanism was tested."	0.3588
35605724	Chemosphere	2022	"The involvement of copper, circular RNAs, and inflammatory cytokines in chronic respiratory disease."	hsa_circ_0010052	circ_0010052			chronic respiratory diseases / CRDs	MONDO:0005087	respiratory system disorder	dysregulated	RT-qPCR; Microarray	circ_0010052 was identified as a CRD-related plasma circRNA and was significantly associated with CRD risk. The study did not provide mechanistic validation for this circRNA.	0.3588
35605724	Chemosphere	2022	"The involvement of copper, circular RNAs, and inflammatory cytokines in chronic respiratory disease."	hsa_circ_0007146	circ_0007146			chronic respiratory diseases / CRDs	MONDO:0005087	respiratory system disorder	dysregulated	RT-qPCR; Microarray	circ_0007146 was identified as one of nine plasma circRNAs associated with increased CRD risk. The article did not test a specific molecular mechanism for circ_0007146.	0.3588
35605724	Chemosphere	2022	"The involvement of copper, circular RNAs, and inflammatory cytokines in chronic respiratory disease."	hsa_circ_0076098	circ_0076098			chronic respiratory diseases / CRDs	MONDO:0005087	respiratory system disorder	up-regulated	RT-qPCR; Microarray	circ_0076098 was up-regulated in plasma from CRD patients and showed a positive statistical association with CRD risk. No mechanistic experiments were reported for this circRNA.	0.3588
35605724	Chemosphere	2022	"The involvement of copper, circular RNAs, and inflammatory cytokines in chronic respiratory disease."	hsa_circ_0022305	circ_0022305			chronic respiratory diseases / CRDs	MONDO:0005087	respiratory system disorder	dysregulated	RT-qPCR; Microarray	circ_0022305 was identified as a CRD-related plasma circRNA significantly associated with disease risk. No downstream interacting molecules or mechanism were reported for circ_0022305.	0.3588
35605724	Chemosphere	2022	"The involvement of copper, circular RNAs, and inflammatory cytokines in chronic respiratory disease."	hsa_circ_0035110	circ_0035110			chronic respiratory diseases / CRDs	MONDO:0005087	respiratory system disorder	down-regulated	RT-qPCR; Microarray	circ_0035110 was down-regulated in plasma from CRD patients and was significantly associated with CRD risk. The study did not experimentally characterize its mechanism.	0.3588
35610079	Burns : journal of the International Society for Burn Injuries	2023	"CircSLC8A1 targets miR-181a-5p/HIF1AN pathway to inhibit the growth, migration and extracellular matrix deposition of human keloid fibroblasts."	hsa_circ_0000994	circSLC8A1	hsa_circ_SLC8A1	SLC8A1	keloid	MONDO:0005348	keloid	down-regulated	RT-qPCR	"circSLC8A1 is down-regulated in keloid tissues and human keloid fibroblasts. Its overexpression inhibits fibroblast proliferation, migration and ECM deposition while promoting apoptosis, mainly by sponging miR-181a-5p to upregulate HIF1AN. The study suggests circSLC8A1 as a potential therapeutic target for keloids."	0.7981
35611720	Histology and histopathology	2022	CircRNF220 plays a pathogenic role to facilitate cell progression of AML in vitro via sponging miR-330-5p to induce upregulation of SOX4.	hsa_circ_0012152	circRNF220	hsa_circ_RNF220	RNF220	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; Microarray	"circRNF220 is up-regulated in AML serum samples and AML cell lines. It promotes AML cell proliferation, cell cycle progression, invasion, and glycolysis while suppressing apoptosis, mainly through sponging miR-330-5p to increase SOX4 expression."	0.8206
35612554	Acta biochimica Polonica	2022	Circ_0014359 promotes oral squamous cell carcinoma progression by sponging miR-149.	hsa_circ_0014359	circ_0014359			oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circ_0014359 is up-regulated in OSCC tissues and cell lines and is associated with patient survival. Functionally, circ_0014359 promotes OSCC cell viability, migration, invasion, EMT and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ_0014359 directly interacts with and sponges miR-149, and inhibition of miR-149 rescues the effects of circ_0014359 knockdown."	0.7548
35636669	Transplant immunology	2022	Knockdown of circ_0026579 ameliorates lipopolysaccharide (bacterial origin)-induced inflammatory injury in bronchial epithelium cells by targeting miR-338-3p/TBL1XR1 axis.	hsa_circ_0026579	circ_0026579	hsa_circ_ESPL1	ESPL1	bronchopneumonia	MONDO:0005682	bronchopneumonia	up-regulated	RT-qPCR	circ_0026579 is up-regulated in serum from bronchopneumonia patients and in LPS-treated BEAS-2B cells. It aggravates LPS-induced bronchial epithelial injury and inflammation by sponging miR-338-3p to increase TBL1XR1 expression; knockdown of circ_0026579 promotes proliferation and suppresses apoptosis and inflammatory cytokine expression. The study suggests circ_0026579 may serve as a diagnostic and therapeutic target for bronchopneumonia.	0.7032
35640631	The Journal of pharmacy and pharmacology	2022	"Circular RNA hsa_circ_0026344 suppresses gastric cancer cell proliferation, migration and invasion via the miR-590-5p/PDCD4 axis."	hsa_circ_0026344	CircRNA_0026344			gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"hsa_circ_0026344/circ_0026344 is down-regulated in gastric cancer tissues and cell lines, and low expression is associated with aggressive clinicopathological features and shorter overall survival. Functionally, circ_0026344 suppresses gastric cancer cell proliferation, migration and invasion. Mechanistically, it acts as a ceRNA for miR-590-5p and indirectly up-regulates PDCD4, forming a circ_0026344/miR-590-5p/PDCD4 tumor-suppressive axis."	0.8323
35642152	Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition	2022	[Correlation between circRNA0003353 in Peripheral Blood Mononuclear Cells and Immune Inflammation in Rheumatoid Arthritis Patients with Damp Heat Obstruction Syndrome].		circRNA 0003353			rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"circRNA 0003353 is up-regulated in PBMCs from rheumatoid arthritis patients with damp heat obstruction syndrome. The study suggests that circRNA 0003353 promotes RA-related immune inflammation, RA-FLS viability and migration by activating the JAK2/STAT3 signaling pathway and modulating IL-10 and IL-17 expression."	0.5414
35642253	Molecular therapy : the journal of the American Society of Gene Therapy	2022	circRNA422 enhanced osteogenic differentiation of bone marrow mesenchymal stem cells during early osseointegration through the SP7/LRP5 axis.		circRNA422	rno_circ_KLHL8	KLHL8	osseointegration	MONDO:0000001	disease	up-regulated	RT-qPCR; Microarray	"This study identified rat circRNA422 from BMSCs cultured on SLA titanium surfaces and showed that its expression is up-regulated during osteogenic differentiation. circRNA422 promotes BMSC proliferation and osteogenic differentiation, enhances early peri-implant bone formation in vivo, and acts through the SP7/LRP5 axis, with SP7 binding sites verified on the LRP5 promoter. The authors propose circRNA422 as a potential therapeutic target for improving implant osseointegration."	0.7566
35647832	European review for medical and pharmacological sciences	2022	CircRIP2 aggravates the deterioration of colorectal carcinoma by negatively regulating CBFB.		circRIP2	hsa_circ_RIP2		colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"CircRIP2 is upregulated in CRC tissues and cell lines and is associated with advanced T stage and distant metastasis. Functionally, circRIP2 promotes CRC cell proliferation, migration and xenograft tumor growth. Mechanistically, it aggravates CRC deterioration through negative regulation of CBFB via a circRIP2/CBFB axis."	0.7113
35648221	Journal of bone and mineral metabolism	2022	CircPVT1 promotes the tumorigenesis and metastasis of osteosarcoma via mediation of miR-26b-5p/CCNB1 axis.		circPVT1	hsa_circ_PVT1	PVT1	Osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"This study reports that circPVT1 is up-regulated in osteosarcoma cells and tissues. Functionally, circPVT1 promotes OS tumorigenesis and metastasis by sponging miR-26b-5p and regulating CCNB1, thereby enhancing proliferation, migration, invasion and in vivo tumor growth while suppressing apoptosis."	0.7053
35649347	Chemotherapy	2022	Circular RNA hsa_circ_0068252 Functions in Cisplatin Resistance and Immune Response via miR-1304-5p/PD-L1 Axis in Non-Small Cell Lung Cancer.	hsa_circ_0068252	circ_0068252			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0068252/circ_0068252 is up-regulated in DDP-resistant NSCLC cells and tumor tissues, and high expression is associated with poor overall survival. It promotes cisplatin resistance and immune escape by acting as a cytoplasmic ceRNA that adsorbs miR-1304-5p to increase PD-L1 expression. Knockdown of circ_0068252 restores DDP sensitivity and enhances CD8+ T cell-mediated anti-tumor activity."	0.7628
35649477	Experimental cell research	2022	Exosomal circ-CACNG2 promotes cardiomyocyte apoptosis in multiple myeloma via modulating miR-197-3p/caspase3 axis.		circ-CACNG2	hsa_circ_CACNG2	CACNG2	multiple myeloma / MM	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR; RNA-seq	"circ-CACNG2 is up-regulated in serum exosomes from MM patients and is associated with MM-related cardiac complications. Mechanistically, MM cell-derived exosomal circ-CACNG2 promotes cardiomyocyte apoptosis and reduces viability by sponging miR-197-3p and increasing caspase3 expression. Clinically, high circ-CACNG2 expression shows diagnostic/prognostic value and predicts poorer cardiac-event-related survival in MM patients."	0.8196
35650159	International heart journal	2022	CircSLC8A1 Exacerbates Hypoxia-Induced Myocardial Injury via Interacting with MiR-214-5p to Upregulate TEAD1 Expression.		CircSLC8A1 / circRNA solute carrier family 8 member A1 antisense RNA 1	mmu_circ_SLC8A1		myocardial infarction / MI	MONDO:0005068	myocardial infarction	up-regulated	RT-qPCR	"This study shows that circSLC8A1 is upregulated in hypoxia-treated HL-1 cardiomyocytes and enriched in exosomes from hypoxic cardiomyocytes. Exosomal circSLC8A1 aggravates hypoxia-induced myocardial injury by inhibiting cell viability and promoting apoptosis, inflammation, and oxidative stress through the miR-214-5p/TEAD1 axis."	0.6578
35662113	Clinical hemorheology and microcirculation	2022	Circ_ARHGAP32 acts as miR-665 sponge to upregulate FGF2 to promote ox-LDL induced vascular smooth muscle cells proliferation and migration.	hsa_circ_0002984	Circ_ARHGAP32	hsa_circ_ARHGAP32	ARHGAP32	atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"Circ ARHGAP32 is up-regulated in serum from atherosclerosis patients and in ox-LDL-treated human VSMCs. It promotes VSMC proliferation and migration by sponging miR-665 and thereby increasing FGF2 expression, suggesting the circ ARHGAP32/miR-665/FGF2 axis as a potential therapeutic target for atherosclerosis."	0.8111
35667514	Cancer letters	2022	Elevated circASCC3 limits antitumor immunity by sponging miR-432-5p to upregulate C5a in non-small cell lung cancer.	hsa_circ_0077495 	circASCC3	hsa_circ_ASCC3	ASCC3	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circASCC3 is up-regulated in NSCLC and further elevated in anti-PD1-refractory patients. It promotes NSCLC progression and anti-tumor immune suppression by sponging miR-432-5p to increase C5/C5a, thereby inducing EMT, M2-like macrophage polarization, PD-L1 upregulation, CD8 + T-cell dysfunction, and resistance to PD1 blockade. High circASCC3 expression is associated with poor prognosis and reduced anti-PD1 efficacy."	0.8961
35667541	Transplant immunology	2022	Lipopolysaccharide-induced lung cell inflammation and apoptosis are enhanced by circ_0003420/miR-424-5p/TLR4 axis via inactivating the NF-kappaB signaling pathway.	hsa_circ_0003420	circ_0003420			sepsis-induced acute lung injury	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR	"circ_0003420 is up-regulated in serum from sepsis-related ALI patients and in LPS-treated BEAS-2B lung epithelial cells. It aggravates LPS-induced lung cell injury by promoting inflammation and apoptosis and suppressing viability/proliferation, mainly through sponging miR-424-5p to increase TLR4 and activate NF-kappaB signaling. The study suggests circ_0003420 may be a therapeutic target for sepsis-induced ALI."	0.7945
35667544	Transplant immunology	2022	Circ_ZNF652 regulates the proliferation and apoptosis of LPS-induced WI-38 cells via miR-302e/TLR4 axis.		circ_ZNF652	hsa_circ_ZNF652	ZNF652	Infantile pneumonia / IP	MONDO:0005249	pneumonia	up-regulated	RT-qPCR	"In this study, circ_ZNF652 was significantly up-regulated in serum from infantile pneumonia patients and in LPS-induced WI-38 cell injury models. Functional assays showed that circ_ZNF652 knockdown alleviated LPS-induced inflammatory injury by enhancing proliferation and reducing apoptosis and inflammatory cytokine release. Mechanistically, circ_ZNF652 acted through the miR-302e/TLR4 axis, suggesting potential therapeutic relevance for IP."	0.7795
35689955	International immunopharmacology	2022	Altered non-coding RNA profiles and potential disease marker identification in peripheral blood mononuclear cells of patients with NMOSD.	hsa_circ_0026993		hsa_circ_STAT2	STAT2	Neuromyelitis optica spectrum disorder / NMOSD	MONDO:0019100	neuromyelitis optica	dysregulated	RT-qPCR; Microarray	"hsa_circ_0026993 was identified as a significantly dysregulated circRNA in PBMCs from NMOSD patients and was validated by RT-qPCR. It showed diagnostic potential for distinguishing NMOSD patients from healthy controls and may contribute to NMOSD pathogenesis through predicted ceRNA regulation or effects on its host gene STAT2, with associated processes including immunomodulation, NF-kappaB signalling, and leukocyte migration."	0.5047
35693076	American journal of cancer research	2022	Circ_0006790 carried by bone marrow mesenchymal stem cell-derived exosomes regulates S100A11 DNA methylation through binding to CBX7 in pancreatic ductal adenocarcinoma.	hsa_circ_0006790	circ_6790 / circMEMO1	hsa_circ_MEMO1	MEMO1	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	down-regulated	RT-qPCR; Microarray	"This study identifies hsa_circ_0006790/circ_6790 as a BM-MSC-derived exosomal circRNA that is reduced in PDAC cells compared with normal pancreatic ductal cells but increased in PDAC cells after Exo treatment. Exosomal circ_6790 binds CBX7, promotes CBX7 nuclear translocation, increases DNMT-mediated methylation of the S100A11 promoter, represses S100A11 transcription, and thereby inhibits PDAC growth, metastasis and immune escape."	0.8179
35693080	American journal of cancer research	2022	"hsa_circ_0001741 promotes esophageal squamous cell carcinoma stemness, invasion and migration by sponging miR-491-5p to upregulate NOTCH3 expression."	hsa_circ_0001741		hsa_circ_TNPO3	TNPO3	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001741 is upregulated in ESCC tissues and cell lines, and high expression is associated with lymph node metastasis, advanced TNM stage and poor survival. It promotes ESCC stemness, invasion, migration, EMT and in vivo tumorigenicity by sponging miR-491-5p and relieving miR-491-5p-mediated suppression of NOTCH3. The study supports hsa_circ_0001741 as a potential prognostic biomarker and therapeutic target for ESCC."	0.892
35695651	"Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer"	2022	Exosomal circRNA_104948 Enhances the Progression of Glioma by Regulating miR-29b-3p and DNMT3B/MTSS1 Signaling.		circRNA_104948	hsa_circ_ZNF85	ZNF85	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; Microarray	"circRNA_104948 is upregulated in glioma plasma exosomes, glioma tissues, and glioma cell lines. Exosomal circRNA_104948 promotes astrocyte proliferation and inhibits apoptosis through a miR-29b-3p/DNMT3B/MTSS1 signaling axis, suggesting potential diagnostic and therapeutic relevance in glioma."	0.6777
35695664	Critical reviews in eukaryotic gene expression	2022	circRNA circRIMS Downregulates miR-505 through Methylation to Suppress Cell Proliferation in Endometrial Cancer.		circRIMS			endometrial cancer / EC	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR	"In endometrial cancer, circRIMS is upregulated in tumor tissues. Functional assays indicate that circRIMS promotes EC cell proliferation, at least partly by decreasing miR-505 expression through increased miR-505 gene methylation."	0.5812
35702791	Current Alzheimer research	2022	ceRNA Network Analysis Reveals AP-1 Transcription Factor Components as Potential Biomarkers for Alzheimer¡¯s Disease.	mmu_circ_0001787	circGLCE	mmu_circ_GLCE	GLCE	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR; RNA-seq	"mmu_circ_0001787/circGLCE is downregulated in the hippocampus of APP/PS1 AD model mice. The study validates a circGLCE/miR-339-5p/Junb ceRNA network, in which circGLCE downregulation is associated with increased miR-339-5p and decreased Junb/AP-1 signaling, suggesting potential biomarker and mechanistic relevance in AD."	0.4474
35702791	Current Alzheimer research	2022	ceRNA Network Analysis Reveals AP-1 Transcription Factor Components as Potential Biomarkers for Alzheimer¡¯s Disease.	mmu_circ_0001899	circFAM120C	mmu_circ_FAM120C	FAM120C	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR; RNA-seq	"mmu_circ_0001899/circFAM120C is downregulated in the hippocampus of APP/PS1 AD model mice. The study validates a circFAM120C/miR-181a-5p/Egr1 ceRNA network, suggesting that this circRNA may regulate Egr1-related transcriptional processes and may serve as a potential biomarker or target in AD."	0.4474
35702791	Current Alzheimer research	2022	ceRNA Network Analysis Reveals AP-1 Transcription Factor Components as Potential Biomarkers for Alzheimer¡¯s Disease.	mmu_circ_0000379	circAKAP6	mmu_circ_AKAP6	AKAP6	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR; RNA-seq	"mmu_circ_0000379/circAKAP6 is significantly downregulated in APP/PS1 mouse hippocampus and appears in predicted ceRNA networks involving miR-455-3p/Egr2 and miR-331-3p/Ier2. Unlike circGLCE and circFAM120C, its complete ceRNA axis was not part of the final validated networks."	0.3684
35702791	Current Alzheimer research	2022	ceRNA Network Analysis Reveals AP-1 Transcription Factor Components as Potential Biomarkers for Alzheimer¡¯s Disease.	mmu_circ_0000659	circTXNDC11	mmu_circ_TXNDC11	TXNDC11	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR; RNA-seq	"mmu_circ_0000659/circTXNDC11 is significantly downregulated in APP/PS1 mouse hippocampus and appears in predicted ceRNA networks involving miR-331-3p/Ier2 and miR-384-5p/Junb. Its expression was validated by qRT-PCR, but its complete ceRNA axis was not among the final two validated networks."	0.3684
35709678	Immunobiology	2022	CircEXOC5 promotes ferroptosis by enhancing ACSL4 mRNA stability via binding to PTBP1 in sepsis-induced acute lung injury.	mmu_circ_0004399	circ_0004399 / circEXOC5	mmu_circ_EXOC5	EXOC5	sepsis-induced acute lung injury	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR	"In sepsis-induced ALI models, circEXOC5 is up-regulated and functions as a disease-promoting circRNA. It binds PTBP1 to increase ACSL4 mRNA stability and ACSL4 expression, thereby promoting ferroptosis, ROS accumulation, and lung injury. Knockdown of circEXOC5 reduces ferroptosis and alleviates lung injury in septic mice and LPS-treated MPVECs."	0.5992
35710311	Carcinogenesis	2022	CircAHNAK upregulates EIF2B5 expression to inhibit the progression of ovarian cancer by modulating the JAK2/STAT3 signaling pathway.	hsa_circ_0022426	circAHNAK	hsa_circ_AHNAK	AHNAK	ovarian cancer / OC	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR	"CircAHNAK is down-regulated in ovarian cancer tissues and cell lines and functions as a tumor suppressor. It sponges miR-28 to relieve repression of EIF2B5, thereby inhibiting JAK2/STAT3 signaling, EMT, proliferation, migration, invasion and xenograft tumor growth while promoting apoptosis."	0.7759
35713481	Human & experimental toxicology	2022	Circle RNA circCSPP1 promotes human osteosarcoma cell proliferation and increases glucose metabolism by suppressing miR-200c maturation.		CircRNA CSPP1 / circCSPP1	hsa_circ_CSPP1	CSPP1	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"This study identifies circCSPP1 as an up-regulated oncogenic circRNA in human osteosarcoma. CircCSPP1 directly interacts with premature miR-200c, suppresses miR-200c maturation, and thereby promotes OS cell proliferation and glucose uptake. Clinically, circCSPP1 expression correlates with tumor size and blood glucose, suggesting potential relevance to tumor growth and metabolic regulation."	0.6432
35718079	Journal of advanced research	2023	Circ-Ddx60 contributes to the antihypertrophic memory of exercise hypertrophic preconditioning.		circ-Ddx60 / c-Ddx	mmu_circ_Ddx60		pathological myocardial hypertrophy	MONDO:0005252	heart failure	down-regulated	RT-qPCR; RNA-seq	"This study identifies mouse c-Ddx/circ-Ddx60 as a novel Ddx60-derived circRNA that is enriched in myocardial tissue and modulated during exercise hypertrophic preconditioning and pressure overload. c-Ddx binds eEF2, promotes eEF2 and AMPK phosphorylation, and contributes to the antihypertrophic memory of EHP, thereby attenuating TAC-induced pathological myocardial hypertrophy and heart failure phenotypes."	0.7898
35722999	Cell biochemistry and function	2022	Relation between the circular and linear form of the Elongator Acetyltransferase Complex Subunit 3 in the progression of triple-negative breast cancer.	hsa_circ_0001785	circ-ELP3	hsa_circ_ELP3	ELP3	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"circ-ELP3/hsa-circ-0001785 is upregulated in TNBC tissues and breast cancer cell lines. Functional overexpression experiments show that it promotes breast cancer cell proliferation, viability, colony formation, and cell cycle progression, and it may act partly through indirect regulation of its host gene ELP3."	0.6996
35722999	Cell biochemistry and function	2022	Relation between the circular and linear form of the Elongator Acetyltransferase Complex Subunit 3 in the progression of triple-negative breast cancer.	hsa_circ_0004619	circ-0004619			triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"hsa-circ-0004619 was selected by bioinformatic analysis as a breast cancer-related circRNA and was tested in TNBC clinical tissues. Its expression was significantly increased in TNBC tumor samples compared with adjacent normal tissues, but no functional or mechanistic experiments were reported for this circRNA."	0.5466
35722999	Cell biochemistry and function	2022	Relation between the circular and linear form of the Elongator Acetyltransferase Complex Subunit 3 in the progression of triple-negative breast cancer.	hsa_circ_0027491	circ-0027491			triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"hsa-circ-0027491 was identified by bioinformatic assessment as a candidate breast cancer-related circRNA and was validated in TNBC clinical samples. It was significantly upregulated in TNBC tissues compared with matched adjacent normal tissues, but the study did not report specific functional assays or molecular mechanisms for this circRNA."	0.5466
35722999	Cell biochemistry and function	2022	Relation between the circular and linear form of the Elongator Acetyltransferase Complex Subunit 3 in the progression of triple-negative breast cancer.	hsa_circ_0004771	circ-0004771			triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"hsa-circ-0004771 was selected as a candidate breast cancer-related circRNA through bioinformatic assessment and then evaluated in TNBC clinical specimens. The study found that it was significantly upregulated in TNBC tissues compared with controls, but no circRNA-specific functional role or molecular mechanism was tested for hsa-circ-0004771."	0.5466
35724457	Biochemical and biophysical research communications	2022	Mesenchymal stem cells-derived exosomes prevent sepsis-induced myocardial injury by a CircRTN4/miR-497-5p/MG53 pathway.		circRTN4	hsa_circ_RTN4	RTN4	sepsis-induced myocardial injury	MONDO:0004994	cardiomyopathy	down-regulated	RT-qPCR	"This study found that circRTN4 is down-regulated in CLP rat cardiac tissues and LPS-treated cardiomyocytes. MSC-derived exosomal circRTN4 protects against sepsis-induced myocardial injury by reducing apoptosis, oxidative stress, and inflammatory cytokines. Mechanistically, circRTN4 functions as a miR-497-5p sponge to increase MG53 expression through the circRTN4/miR-497-5p/MG53 axis."	0.7827
35724457	Biochemical and biophysical research communications	2022	Mesenchymal stem cells-derived exosomes prevent sepsis-induced myocardial injury by a CircRTN4/miR-497-5p/MG53 pathway.		circRTN4	rno_circ_RTN4	RTN4	sepsis-induced myocardial injury	MONDO:0004994	cardiomyopathy	down-regulated	RT-qPCR	"This study found that circRTN4 is down-regulated in CLP rat cardiac tissues and LPS-treated cardiomyocytes. MSC-derived exosomal circRTN4 protects against sepsis-induced myocardial injury by reducing apoptosis, oxidative stress, and inflammatory cytokines. Mechanistically, circRTN4 functions as a miR-497-5p sponge to increase MG53 expression through the circRTN4/miR-497-5p/MG53 axis."	0.7827
35733309	Protein and peptide letters	2022	Hsa_circ_0000437 Inhibits the Development of Endometrial Carcinoma through miR-626/CDKN1B Axis.	hsa_circ_0000437	circ_0000437			endometrial cancer / EC	MONDO:0011962	endometrial cancer	down-regulated	RT-qPCR	"hsa_circ_0000437 is down-regulated in endometrial carcinoma tissues and cell lines. It functions as a tumor-suppressive circRNA by sponging miR-626 and regulating CDKN1B expression, thereby inhibiting EC cell proliferation, invasion and EMT. Low circ_0000437 expression is associated with lymph node metastasis and high TNM stage, suggesting potential biomarker or therapeutic value."	0.7785
35747942	Histology and histopathology	2023	Sevoflurane suppresses hepatocellular carcinoma cell progression via circ_0001649/miR-19a-3p/SGTB axis.	hsa_circ_0001649	circ_0001649			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"circ_0001649 is down-regulated in HCC cell lines and is induced by sevoflurane treatment. It suppresses HCC cell proliferation, migration and invasion while promoting apoptosis, and mediates sevoflurane-induced anti-tumor effects through the circ_0001649/miR-19a-3p/SGTB axis."	0.627
35752700	Molecular biology reports	2022	Rheumatoid arthritis fibroblast-like synoviocytes maintain tumor-like biological characteristics through ciRS-7-dependent regulation of miR-7.		Cerebellar degenerationrelated protein 1 antisense RNA (CDR1as) / ciRS-7			rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"This study found that ciRS-7 is up-regulated in RA-FLS compared with HC-FLS and negatively regulates miR-7. ciRS-7 appears to maintain tumor-like RA-FLS biological characteristics through a miR-7 sponge-related mechanism, with effects on proliferation, migration, invasion, apoptosis and cell-cycle behavior. The ciRS-7/miR-7 interaction is proposed as a potential contributor to rheumatoid arthritis pathogenesis and progression."	0.5802
35759156	Biochemical genetics	2023	Circ_0000395 Promoted CRC Progression via Elevating MYH9 Expression by Sequestering miR-432-5p.	hsa_circ_0000395	hsa_circRNA_001046 / circ_0000395	hsa_circ_SLC38A1	SLC38A1	Colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"In this study, hsa_circ_0000395/circ_0000395 was up-regulated in CRC tissues, CRC cell lines, and CRC cell-derived exosomes. It promoted CRC progression by enhancing proliferation, migration, invasion, EMT and tumor growth while suppressing apoptosis. Mechanistically, circ_0000395 sponged miR-432-5p to increase MYH9 expression, and exosomal circ_0000395 contributed to malignant phenotypes of recipient CRC cells."	0.7898
35759302	"Shock (Augusta, Ga.)"	2022	Circular RNA UBAP2 (hsa_circ_0007367) Correlates with Microcirculatory Perfusion and Predicts Outcomes of Cardiogenic Shock Patients Undergoing Extracorporeal Membrane Oxygenation Support.	hsa_circ_0007367	circUBAP2 / Circular RNA UBAP2	hsa_circ_UBAP2	UBAP2	cardiogenic shock	MONDO:0800175	cardiogenic shock	unknown	RT-qPCR	"In cardiogenic shock patients receiving V-A ECMO, higher blood circUBAP2 expression is associated with improved microcirculatory perfusion, better 30-day survival, and lower in-hospital mortality risk. Functionally, circUBAP2 suppresses macrophage migration and inflammatory cytokine production, promotes M2 polarization, and inhibits the PI3K/Akt/mTOR pathway."	0.6527
35764065	"Cells, tissues, organs"	2025	circ_0062582 Promotes Osteogenic Differentiation of Human Bone Marrow Mesenchymal Stem Cells in vitro by Elevating SMAD5 Expression through Sponging miR-197-3p.	hsa_circ_0062582	circ_0062582			Osteoporosis / OP	MONDO:0005298	osteoporosis	down-regulated	RT-qPCR	"circ_0062582 is downregulated in serum from osteoporosis patients and increases during osteogenic induction of hBMSCs. In vitro, circ_0062582 promotes hBMSC viability, osteogenic differentiation, osteogenic marker expression, ALP activity, and mineralization. Mechanistically, it functions as a miR-197-3p sponge to elevate SMAD5 expression, suggesting a potential therapeutic relevance in OP."	0.7684
35771357	Molecular biology reports	2022	Novel circularRNA circ-0047078 promotes pancreatic ductal adenocarcinoma progression through mircoRNA miR-11181- Chemokine (C-X-C motif) Ligand 12/Melanoma Cell Adhesion Molecule/Regulator of G-protein signaling 16 pathway.	hsa_circ_0047078	circ-0047078			pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circ-0047078 is up-regulated in PDAC tissues and promotes malignant phenotypes of CFPAC-1 pancreatic cancer cells, including proliferation and invasion, while suppressing apoptosis. Its effects are mediated through miR-11181-dependent regulation of CXCL12, MCAM and RGS16, and higher expression is associated with lymphatic metastasis and perineural invasion."	0.6093
35771357	Molecular biology reports	2022	Novel circularRNA circ-0047078 promotes pancreatic ductal adenocarcinoma progression through mircoRNA miR-11181- Chemokine (C-X-C motif) Ligand 12/Melanoma Cell Adhesion Molecule/Regulator of G-protein signaling 16 pathway.	hsa_circ_0054234	circ-0054234			pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circ-0054234 was identified by ceRNA microarray as up-regulated in PDAC tissues compared with adjacent tissues. Its expression was also higher in Panc-1 pancreatic cancer cells than in HPDE6-C7 normal pancreatic cells by RT-qPCR, but the study did not report functional experiments or a defined mechanism for this circRNA."	0.4032
35772185	The Journal of surgical research	2022	Silencing of Circ_0135889 Restrains Proliferation and Tumorigenicity of Human Neuroblastoma Cells.	hsa_circ_0135889	circ_0135889 / hsa_circ argonaute 2 _001	hsa_circ_AGO2	AGO2	Neuroblastoma / NB	MONDO:0005072	neuroblastoma	up-regulated	RT-qPCR	"Hsa_circ_0135889 is an AGO2-derived human circRNA upregulated in neuroblastoma tissues and cell lines. It promotes proliferation, migration, invasion and xenograft tumor growth while inhibiting apoptosis, acting through a circ_0135889/miR-127-5p/NEUROD1 ceRNA axis. Its expression is associated with tumor size and INSS stage, supporting its potential as a therapeutic target."	0.7759
35772682	Transplant immunology	2022	Hsa_circ_0010729 regulates H2O2-induced myocardial injury by regulating miR-1184/RIPK1 axis.	hsa_circ_0010729	circ_0010729			myocardial ischemia/reperfusion injury	MONDO:0005203	ischemia reperfusion injury	up-regulated	RT-qPCR	"This study found that circ_0010729 is up-regulated in H2O2-exposed human cardiac myocytes and aggravates myocardial injury. Mechanistically, circ_0010729 functions as a sponge for miR-1184, thereby regulating RIPK1, promoting apoptosis and oxidative stress, and inhibiting proliferation."	0.6207
35777132	Biochemical and biophysical research communications	2022	CircPDHX promotes prostate cancer cell progression in vitro and tumor growth in vivo via miR-497-5p/ACSL1 axis.		circRNA pyruvate dehydrogenase complex component X / circPDHX	hsa_circ_PDHX	PDHX	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"CircPDHX is upregulated in prostate cancer tissues and cells and functions as an oncogenic circRNA. Its knockdown suppresses PCa cell proliferation, migration, fatty acid metabolism and xenograft tumor growth, while promoting apoptosis. Mechanistically, circPDHX sponges miR-497-5p to regulate ACSL1."	0.8299
35777791	Annals of clinical and laboratory science	2022	Circular RNA circSEPT9 Is Upregulated in Endometrial Cancer and Promotes Cell Invasion and Migration by Downregulating miR-186 through Methylation.		circSEPT9	hsa_circ_SEPT9	SEPT9	endometrial cancer / EC	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR; RNA-seq	"circSEPT9 is upregulated in endometrial cancer tissues and functions as a pro-metastatic circRNA in EC cell models. Mechanistically, circSEPT9 acts upstream of miR-186, increasing methylation of the miR-186 gene and reducing miR-186 expression, thereby promoting EC cell invasion and migration."	0.5812
35810770	Experimental eye research	2022	"Circ_0060,144 inhibits the occurrence and development of age-related cataract via the miR-23b-3p/HIPK3 axis."	hsa_circ_0060144	"circ_0060,144"	hsa_circ_PHF20	PHF20	age-related cataract / ARC	MONDO:0004847	senile cataract	down-regulated	RT-qPCR	"circ_0060,144 is significantly down-regulated in ARC lens tissues. In SRA01/04 human lens epithelial cells, circ_0060,144 overexpression promotes proliferation, suppresses apoptosis, and reduces oxidative/peroxidation-related damage. Mechanistically, circ_0060,144 acts as a miR-23b-3p sponge to positively regulate HIPK3, suggesting potential value as a target for ARC prevention and treatment."	0.7289
35812044	American journal of cancer research	2022	CircUBR5 acts as a ceRNA for miR-1179 to up-regulate UBR5 and to promote malignancy of triple-negative breast cancer.	hsa_circ_0001819	circUBR5	hsa_circ_UBR5	UBR5	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"circUBR5 is a UBR5-derived human circRNA that is up-regulated in TNBC tissues and cells and whose high expression predicts poorer overall survival. It promotes TNBC cell proliferation, viability, migration, invasion, xenograft growth, and lung metastasis by sponging miR-1179 and up-regulating UBR5. The study supports circUBR5 as a prognostic biomarker and potential therapeutic target in TNBC."	0.8658
35812061	American journal of cancer research	2022	CircNRIP1 acts as a sponge of miR-1200 to suppress osteosarcoma progression via upregulation of MIA2.	hsa_circ_0004771	circNRIP1	hsa_circ_NRIP1	NRIP1	osteosarcoma / OS	MONDO:0009807	osteosarcoma	down-regulated	RT-qPCR; Microarray	"circNRIP1 (hsa_circ_0004771), derived from NRIP1, is downregulated in osteosarcoma cell lines and mainly localized in the cytoplasm. Its overexpression suppresses osteosarcoma proliferation, migration, invasion, and xenograft growth by sponging miR-1200 and upregulating the miR-1200 target gene MIA2."	0.8109
35816943	International immunopharmacology	2022	Hsa_circ_0093884 bound to RNA-binding protein RPS3 ameliorates hepatocyte inflammation in anti-tuberculosis drug-induced liver injury by competitively activating SIRT1.	hsa_circ_0093884		hsa_circ_SIRT1	SIRT1	liver injury	MONDO:0005154	liver disorder	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0093884 is a SIRT1-derived human circRNA that is down-regulated in serum samples from ADLI patients and in an in vitro ADLI hepatocyte model. It binds the RNA-binding protein RPS3 to activate/increase SIRT1 expression, thereby suppressing NLRP3 inflammasome-related inflammatory responses and alleviating hepatocyte injury."	0.813
35818196	"Cellular and molecular biology (Noisy-le-Grand, France)"	2022	Effect of Solanum lyratum Polysaccharide on Malignant Behaviors of Lung Cancer Cells by Regulating the Circ_UHRF1/miR-513b-5p Axis.		Circ_UHRF1	hsa_circ_UHRF1	UHRF1	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circ_UHRF1 is up-regulated in lung cancer tissues and functions as a pro-tumor circRNA in A549 lung cancer cells. Knockdown of circ_UHRF1 inhibits proliferation, migration and invasion, promotes apoptosis, increases Bax and decreases Bcl-2. The study suggests that Solanum lyratum polysaccharide suppresses lung cancer cell malignant behavior by down-regulating circ_UHRF1 and thereby increasing miR-513b-5p through the circ_UHRF1/miR-513b-5p axis."	0.6536
35818779	Histology and histopathology	2023	"Circ_0067717 promotes colorectal cancer cell growth, invasion and glutamine metabolism by serving as a miR-497-5p sponge to upregulate SLC7A5."	hsa_circ_0067717	circ_0067717			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0067717 is up-regulated in colorectal cancer tissues and cell lines and is associated with advanced clinicopathological features. Functionally, it promotes CRC cell growth, invasion, glutamine metabolism and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ_0067717 acts as a sponge for miR-497-5p to upregulate SLC7A5."	0.7661
35818964	Neoplasma	2022	hsa_circ_0067514 suppresses gastric cancer progression and glycolysis via miR-654-3p/LATS2 axis.	hsa_circ_0067514	circ_0067514	hsa_circ_CEP70		gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"hsa_circ_0067514 is down-regulated in gastric cancer tissues and cells, and low expression is associated with poor overall survival and adverse clinicopathological features. Functionally, circ_0067514 suppresses gastric cancer proliferation, invasion, EMT, glycolysis, and xenograft tumor growth. Mechanistically, it acts as a miR-654-3p sponge to upregulate LATS2, forming a circ_0067514/miR-654-3p/LATS2 axis."	0.8489
35831154	International heart journal	2022	Hsa_circ_0030042 Ameliorates Oxidized Low-Density Lipoprotein-Induced Endothelial Cell Injury via the MiR-616-3p/RFX7 Axis.	hsa_circ_0030042	circ_0030042	hsa_circ_FOXO1	FOXO1	Atherosclerosis / AS	MONDO:0005311	atherosclerosis	down-regulated	RT-qPCR	"This study identifies hsa_circ_0030042 as a down-regulated circRNA in ox-LDL-induced endothelial cell models of atherosclerosis. Functionally, circ_0030042 protects endothelial cells by promoting proliferation while suppressing apoptosis and inflammatory cytokine release. Mechanistically, it acts through the circ_0030042/miR-616-3p/RFX7 regulatory network and may represent a potential biomarker or therapeutic target for AS."	0.7817
35835384	Fish & shellfish immunology	2022	Genome-wide identification m6A modified circRNAs revealed their key roles in skin ulceration syndrome disease development in Apostichopus japonicus.		MRZV01001545.1:107964-126376+			skin ulceration syndrome	MONDO:0000001	disease	up-regulated	RNA-seq	"MRZV01001545.1:107964-126376+ was identified as an upregulated m6A-modified circRNA in SUS-diseased sea cucumbers. The study proposed that it participates in an m6A-influenced ceRNA network by binding aja-miR-n34-5p and targeting Ajpolyubiquitin, implicating the ubiquitylation system in SUS disease progression."	0.5803
35835384	Fish & shellfish immunology	2022	Genome-wide identification m6A modified circRNAs revealed their key roles in skin ulceration syndrome disease development in Apostichopus japonicus.		MRZV01001322.1:161535-168532-			skin ulceration syndrome	MONDO:0000001	disease	up-regulated	RNA-seq	"MRZV01001322.1:161535-168532- was identified as an upregulated circRNA in the SUS-diseased group. It was included in a predicted circRNA-miRNA-mRNA network in which it binds aja-miR-n34-5p and targets Ajpolyubiquitin, suggesting a potential role in the ubiquitylation-related response during SUS progression."	0.5415
35835384	Fish & shellfish immunology	2022	Genome-wide identification m6A modified circRNAs revealed their key roles in skin ulceration syndrome disease development in Apostichopus japonicus.		MRZV01000129.1:769508-769739			skin ulceration syndrome	MONDO:0000001	disease	up-regulated	RNA-seq	MRZV01000129.1:769508-769739 was highlighted in the SUS-diseased group as part of an m6A circRNA-miRNA-mRNA network. The proposed axis MRZV01000129.1:769508-769739/aja-miR-2002-3p/Ajzonadhesin may contribute to SUS pathogenesis through adhesion-related processes.	0.5803
35835384	Fish & shellfish immunology	2022	Genome-wide identification m6A modified circRNAs revealed their key roles in skin ulceration syndrome disease development in Apostichopus japonicus.		MRZV01000895.1:48773-72891+			skin ulceration syndrome	MONDO:0000001	disease	down-regulated	RNA-seq	"MRZV01000895.1:48773-72891+ was reported as a downregulated circRNA in the SUS-resistant group. It was linked to m6A-influenced ceRNA regulation through aja-miR-n34-5p/Ajpolyubiquitin and aja-miR-2007-5p/Ajsco-spondin networks, implicating ubiquitination and adhesion-related mechanisms in SUS disease development or resistance."	0.5803
35838496	Molecular cancer research : MCR	2022	circ_0041732 Promotes Breast Cancer Progression.	hsa_circ_0041732	hsa_circRNA_101967 / circ_0041732	hsa_circ_FAM64A	FAM64A	Breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circ_0041732 is an oncogenic circRNA up-regulated in breast cancer cells and tissues. Its up-regulation is driven by E2F4-mediated transcriptional activation of its host gene FAM64A, and it promotes proliferation, cell cycle progression, and xenograft tumor growth while suppressing apoptosis by sponging miR-541-3p to increase RelA and GLI4 and activate NF-kB and Hedgehog signaling."	0.8478
35839486	Human & experimental toxicology	2022	Hsa_circ_0000285 knockdown inhibits the progression of hepatocellular carcinoma by sponging miR-582-3p to regulate CCNB2 expression.	hsa_circ_0000285	circ_0000285	hsa_circ_HIPK3	HIPK3	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"hsa_circ_0000285 is up-regulated in HCC tumor tissues and cell lines and acts as an oncogenic circRNA. It promotes proliferation, migration and tumor growth while inhibiting apoptosis, mainly by sponging miR-582-3p to up-regulate CCNB2. The study suggests hsa_circ_0000285 as a potential therapeutic and diagnostic target for HCC."	0.7795
35839920	Cancer letters	2022	"Vimentin binds to a novel tumor suppressor protein, GSPT1-238aa, encoded by circGSPT1 with a selective encoding priority to halt autophagy in gastric carcinoma."		circGSPT1 / hsa_circ_16168	hsa_circ_GSPT1	GSPT1	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; RNA-seq	"circGSPT1 is a human GSPT1-derived circular RNA that is downregulated in gastric carcinoma tissues and cell lines. It encodes the tumor suppressor peptide GSPT1-238aa through IRES-mediated translation, and this peptide binds the vimentin/Beclin1/14-3-3 complex to inhibit PI3K/AKT/mTOR signaling, autophagy, proliferation, migration, and invasion in GC cells. Reduced circGSPT1 expression is associated with lymphatic metastases, supporting its potential clinical relevance in GC."	0.8382
35844201	Journal of digestive diseases	2022	Circular RNA circ_0006089 promotes the progression of gastric cancer by regulating the miR-143-3p/PTBP3 axis and PI3K/AKT signaling pathway.	hsa_circ_0006089	circ_0006089	hsa_circ_ASAP2	ASAP2	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"circ_0006089 is upregulated in gastric cancer tissues and cells and is associated with advanced disease features and poor survival. Functionally, it promotes proliferation, migration, invasion, EMT, metastasis, and tumor growth while suppressing apoptosis. Mechanistically, circ_0006089 sponges miR-143-3p to regulate PTBP3 and activate PI3K/AKT signaling."	0.8175
35848890	Human molecular genetics	2022	Immunomodulatory functions of the circ_001678/miRNA-326/ZEB1 axis in non-small cell lung cancer via the regulation of PD-1/PD-L1 pathway.		circRNA_001678 / circ_001678			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ_001678 is up-regulated in NSCLC tissues and cells and promotes malignant phenotypes including proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, it sponges miR-326 to increase ZEB1 expression, activates the PD-1/PD-L1 pathway, promotes CD8+ T cell apoptosis, and facilitates immune escape in NSCLC."	0.8322
35852112	Epigenomics	2022	hsa_circ_0092339 acts as a molecular sponge in castration-resistant prostate cancer via the hsa-mir-940/C-MYC axis.	hsa_circ_0092339		hsa_circ_RABGGTB	RABGGTB	castration-resistant prostate cancer	MONDO:0850353	castration-resistant prostate carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"hsa_circ_0092339 is an intronic circRNA derived from RABGGTB and is up-regulated in CRPC cell lines and CRPC patient tissues. It promotes CRPC proliferation, migration, clonogenicity and xenograft tumor growth by acting as a nuclear molecular sponge for hsa-mir-940, thereby preventing C-MYC mRNA degradation and sustaining C-MYC signaling."	0.8668
35857217	Biochemical genetics	2023	Knockdown of Circ_0000798 Impedes Cell Growth and Motility of Renal Cell Carcinoma Cells Through Functioning as miRNA Sponge for miR-589-5p.	hsa_circ_0000798		hsa_circ_BPTF	BPTF	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR	"Circ_0000798 is a BPTF-derived human circRNA upregulated in RCC tissues and cell lines, and high expression is associated with poorer overall survival. Functionally, circ_0000798 promotes RCC cell growth, colony formation, migration, invasion, and xenograft tumor growth while suppressing apoptosis. Mechanistically, it acts as a miR-589-5p sponge to increase G3BP1 expression, forming a circ_0000798/miR-589-5p/G3BP1 ceRNA axis."	0.8656
35866630	Toxicological sciences : an official journal of the Society of Toxicology	2022	Upregulation of Circ_0035266 Contributes to the Malignant Progression of Inflammation-Associated Malignant Transformed Cells Induced by Tobacco-Specific Carcinogen NNK.	hsa_circ_0035266	Circ_0035266			lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; Microarray	"circ_0035266 is an upregulated human circRNA in NNK and LPS-exposed bronchial epithelial cells and in lung cancer tissues. It promotes inflammatory cytokine regulation, proliferation, cell cycle progression, migration, and malignant progression of transformed BEAS-2B cells, likely through a ceRNA-related miR-181d-5p/DDX3X mechanism."	0.5828
35866672	Histology and histopathology	2023	Circ_0000520 interacts with miR-512-5p to upregulate KIAA0100 to promote malignant behaviors in lung cancer.	hsa_circ_0000520	Circ_0000520			lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"circ_0000520 is up-regulated in lung cancer tissues and cells and functions as an oncogenic circRNA. It promotes proliferation, cell cycle progression, migration, invasion, angiogenesis and xenograft tumor growth while suppressing apoptosis, partly through sponging miR-512-5p to increase KIAA0100 expression. The study suggests circ_0000520 may serve as a potential biomarker for lung cancer."	0.7861
35871508	Nephron	2023	Circ_0068087 Promotes High Glucose-Induced Human Renal Tubular Cell Injury through Regulating miR-106a-5p/ROCK2 Pathway.	hsa_circ_0068087	circ_0068087	hsa_circ_GNB4	GNB4	diabetic nephropathy / DN	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"circ_0068087 is up-regulated in serum from DN patients and in high glucose-induced HK2 cells. It promotes high glucose-induced renal tubular cell injury by sponging miR-106a-5p and increasing ROCK2 expression, thereby inhibiting proliferation and promoting apoptosis, oxidative stress, inflammation, and fibrosis. Its knockdown may represent a potential circRNA-targeted therapeutic strategy for DN."	0.7949
35876150	"Experimental biology and medicine (Maywood, N.J.)"	2022	"hsa-miR-607, lncRNA TUG1 and hsa_circ_0071106 can be combined as biomarkers in type 2 diabetes mellitus."	hsa_circ_0071106				type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RT-qPCR; Microarray	"hsa_circ_0071106 was up-regulated in peripheral blood from T2DM patients and was evaluated as a diagnostic biomarker. Its combination with hsa-miR-607 and lncRNA TUG1 improved diagnostic performance for T2DM, and bioinformatics suggested involvement in miRNA interactions and MAPK-related insulin signaling."	0.5047
35876150	"Experimental biology and medicine (Maywood, N.J.)"	2022	"hsa-miR-607, lncRNA TUG1 and hsa_circ_0071106 can be combined as biomarkers in type 2 diabetes mellitus."	hsa_circ_0000284				type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000284 was up-regulated in T2DM peripheral blood samples and was validated by qRT-PCR after microarray screening. It was assessed as a potential diagnostic circRNA, although the reported individual ROC result was not statistically significant."	0.4679
35876150	"Experimental biology and medicine (Maywood, N.J.)"	2022	"hsa-miR-607, lncRNA TUG1 and hsa_circ_0071106 can be combined as biomarkers in type 2 diabetes mellitus."	hsa_circ_0071271				type 2 diabetes mellitus / T2DM	MONDO:0005148	type 2 diabetes mellitus	up-regulated	RT-qPCR; Microarray	"hsa_circ_0071271 was up-regulated in peripheral blood from T2DM patients and was validated by qRT-PCR after microarray screening. The study evaluated it as a candidate diagnostic circRNA, but its individual ROC diagnostic performance was weak and not statistically significant."	0.4679
35882184	International archives of allergy and immunology	2022	Peripheral Circular RNA Profiling from Patients with Allergic Rhinitis Identified hsa_circRNA_404013 as a Potential Diagnostic Biomarker.		hsa_circRNA_404013			allergic rhinitis / AR	MONDO:0011786	allergic rhinitis	up-regulated	RT-qPCR; Microarray	"This study identified hsa_circRNA_404013 as significantly up-regulated in peripheral blood from AR patients and validated this finding by RT-qPCR in a larger clinical cohort. Its expression correlated with nasal symptoms and BDNF levels, and ROC analysis suggested diagnostic biomarker potential. Bioinformatics analysis proposed a hsa_circRNA_404013/hsa-mir-182-5p/BDNF regulatory axis that may contribute to AR pathogenesis."	0.6616
35894462	Protein and peptide letters	2022	Circ_0008768 Suppresses the Pancreatic Cancer Progression via miR-330- 3p/PTEN Axis.	hsa_circ_0008768	circular RNA_0008768			pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	down-regulated	RT-qPCR; Microarray	"circ_0008768 is down-regulated in pancreatic cancer tissues and cell lines. It suppresses PC cell proliferation, migration and invasion by sponging miR-330-3p and thereby upregulating PTEN expression. The study suggests circ_0008768 may have diagnostic biomarker potential in PC."	0.6815
35899951	Protein and peptide letters	2022	Hsa_circ_0008092 Contributes to Cell Proliferation and Metastasis in Hepatocellular Carcinoma via the miR-502-5p/CCND1 Axis.	hsa_circ_0008092				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0008092 is up-regulated in HCC tissues, cells, and plasma datasets, and high expression is associated with shorter overall survival. Functionally, it promotes HCC cell proliferation, migration and invasion while inhibiting apoptosis. Mechanistically, circ_0008092 acts as a miR-502-5p sponge to indirectly up-regulate CCND1 through the circ_0008092/miR-502-5p/CCND1 axis."	0.7941
35900059	Histology and histopathology	2023	Knockdown of circ_0004585 enhances the chemosensitivity of colorectal cancer cells to 5-fluorouracil via the miR-874-3p/CCND1 axis.	hsa_circ_0004585	circ_0004585			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0004585 is up-regulated in CRC tissues and cells, with even higher expression in 5-FU-resistant CRC samples and cell lines. Functionally, circ_0004585 promotes malignant phenotypes and 5-FU resistance, while its knockdown suppresses proliferation, migration, invasion, angiogenic tube formation, and tumor growth and promotes apoptosis. Mechanistically, circ_0004585 acts through the miR-874-3p/CCND1 axis to regulate CRC progression and chemoresistance."	0.6544
35905561	International immunopharmacology	2022	Circ_0008287 promotes immune escape of gastric cancer cells through impairing microRNA-548c-3p-dependent inhibition of CLIC1.	hsa_circ_0008287	circ_0008287			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circ_0008287 is up-regulated in gastric cancer and promotes malignant phenotypes including proliferation, invasion, migration, tumorigenesis and metastasis. Mechanistically, it sponges miR-548c-3p to increase CLIC1 expression, impairing CD8+ T cell function and promoting T cell apoptosis, thereby enhancing immune escape. Higher circ_0008287 expression is associated with poorer overall survival and aggressive clinicopathological features."	0.7421
35907337	International immunopharmacology	2022	Suppression of circXPO1 attenuates cigarette smoke-induced inflammation and cellular senescence of alveolar epithelial cells in chronic obstructive pulmonary disease.	hsa_circ_0001016		hsa_circ_XPO1	XPO1	chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR	"circXPO1 is up-regulated in CS-exposed mouse lungs and CSE-treated MLE12 alveolar epithelial cells. It promotes inflammatory cytokine production and cellular senescence by sponging miR-23b-3p, releasing TAB3 and activating NF-kappaB signaling; knockdown of circXPO1 attenuates these COPD-related phenotypes in vitro and in vivo."	0.6867
35907337	International immunopharmacology	2022	Suppression of circXPO1 attenuates cigarette smoke-induced inflammation and cellular senescence of alveolar epithelial cells in chronic obstructive pulmonary disease.	mmu_circ_0000246				chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR	"circXPO1 is up-regulated in CS-exposed mouse lungs and CSE-treated MLE12 alveolar epithelial cells. It promotes inflammatory cytokine production and cellular senescence by sponging miR-23b-3p, releasing TAB3 and activating NF-kappaB signaling; knockdown of circXPO1 attenuates these COPD-related phenotypes in vitro and in vivo."	0.6867
35908953	Endocrine journal	2022	Re-expression of circ_0043610 contributes to trophoblast dysfunction through the miR-558/RYBP pathway in preeclampsia.	hsa_circ_0043610	circ_0043610			preeclampsia / PE	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR; Microarray	"In preeclampsia, circ_0043610 is up-regulated in placental tissues and mainly localized in the cytoplasm of trophoblast cells. It promotes trophoblast dysfunction by sponging miR-558 and increasing RYBP expression, which inhibits proliferation, invasion and migration while inducing apoptosis. The authors suggest that repressing circ_0043610 may represent a potential therapeutic strategy for PE."	0.7981
35913453	Molecular cancer research : MCR	2022	Circ_0001821 Affects Proliferation and the Cell Cycle in Esophageal Squamous Cell Carcinoma by Elevating BTRC-Mediated IKBA Ubiquitination.	hsa_circ_0001821	hsa_circRNA_000006	hsa_circ_PVT1	PVT1	Esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"circ_0001821 is up-regulated in ESCC cells and acts as an oncogenic circRNA. RUNX3 transcriptionally enhances PVT1/circ_0001821 expression, and circ_0001821 promotes ESCC proliferation, cell cycle progression, and tumor growth through the miR-423-5p/BTRC axis, increasing IKBA ubiquitination and activating NF-kappaB signaling."	0.8363
35916080	Epigenomics	2022	Circular RNA circTTBK2 facilitates non-small-cell lung cancer malignancy through the miR-873-5p/TEAD1/DERL1 axis.	hsa_circ_0000594		hsa_circ_TTBK2	TTBK2	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circTTBK2 is a human TTBK2-derived circRNA that is up-regulated in NSCLC tissues and cell lines, and high expression is associated with poorer prognosis, TNM stage and lymph node metastasis. Functionally, circTTBK2 promotes NSCLC cell proliferation, migration, invasion and xenograft tumor growth. Mechanistically, cytoplasmic circTTBK2 sponges miR-873-5p to increase TEAD1, which transcriptionally activates DERL1, forming the circTTBK2/miR-873-5p/TEAD1/DERL1 oncogenic axis."	0.8655
35916453	Head & neck	2022	Overexpression of circFNDC3B promotes the progression of oral tongue squamous cell carcinoma through the miR-1322/MED1 axis.	hsa_circ_0006156	circFNDC3B	hsa_circ_FNDC3B	FNDC3B	oral tongue squamous cell carcinoma / OTSCC	MONDO:0018708	squamous cell carcinoma of the oral tongue	up-regulated	RT-qPCR; ISH	"circFNDC3B is up-regulated in OTSCC tissues and cell lines and acts as an oncogenic circRNA. It promotes proliferation, migration, invasion, and xenograft tumor growth through the circFNDC3B/miR-1322/MED1 regulatory axis, suggesting potential therapeutic relevance in OTSCC."	0.7795
35917517	Clinical cancer research : an official journal of the American Association for Cancer Research	2022	CircIPO7 Promotes Nasopharyngeal Carcinoma Metastasis and Cisplatin Chemoresistance by Facilitating YBX1 Nuclear Localization.	hsa_circ_0004672	circIPO7	hsa_circ_IPO7	IPO7	nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; RNA-seq	"circIPO7 (hsa_circ_0004672) is an IPO7-derived circRNA upregulated in NPC, especially in patients with distant metastasis. It promotes NPC migration, invasion, metastasis and cisplatin chemoresistance by binding YBX1 in the cytoplasm, facilitating AKT-mediated YBX1 phosphorylation and nuclear translocation, and activating FGFR1, TNC and NTRK1 transcription. Clinically, high circIPO7 expression predicts increased distant metastasis risk and poor survival after cisplatin-based chemotherapy."	0.9064
35918573	Inflammation	2023	"Circ_0088194 Regulates Proliferation, Migration, Apoptosis, and Inflammation by miR-30a-3p/ADAM10 Axis in Rheumatoid Arthritis Fibroblastic Synovial Cells."	hsa_circ_0088194	circ_0088194	hsa_circ_TNC	TNC	rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	up-regulated	RT-qPCR	"Circ_0088194 is up-regulated in RA synovial tissues and RA-FLSs. It promotes RA-FLS proliferation, migration, and inflammatory cytokine secretion while suppressing apoptosis, at least partly through a ceRNA mechanism involving miR-30a-3p and ADAM10. The study proposes circ_0088194 as a potential therapeutic target for rheumatoid arthritis."	0.7977
35920365	Histology and histopathology	2023	Circular RNA circLRCH3 promotes oxaliplatin resistance in gastric cancer through the modulation of the miR-383-5p/FGF7 axis.	hsa_circ_0005873	circRNA leucine rich repeats and calponin homology domain containing 3	hsa_circ_LRCH3	LRCH3	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circLRCH3 is up-regulated in gastric cancer and especially in oxaliplatin-resistant GC tissues and cells. It promotes OXA resistance by sponging miR-383-5p and increasing FGF7 expression; circLRCH3 knockdown suppresses proliferation, migration, invasion and multidrug resistance markers, induces apoptosis, and enhances OXA sensitivity in vitro and in vivo."	0.705
35924589	Histology and histopathology	2023	"Circ_DLEU2 knockdown represses cell proliferation, migration and invasion, and induces cell apoptosis through the miR-582-5p/COX2 pathway in acute myeloid leukemia."	hsa_circ_0000488	circ_DLEU2 / circ_0000488	hsa_circ_DLEU2	DLEU2	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"circ_DLEU2 is up-regulated in AML marrow samples and AML cell lines and functions as a tumor-promoting circRNA. Its knockdown suppresses AML cell proliferation, promotes G0/G1 arrest, and induces apoptosis. Mechanistically, circ_DLEU2 acts through a miR-582-5p/COX2 axis and may serve as a predictive marker in AML."	0.7591
35926312	The Journal of surgical research	2022	"Circ_0,007,331 Promotes the PTX Resistance and Progression of Breast Cancer via miR-200b-3p/ANLN."	hsa_circ_0007331	"circ_0,007,331"	hsa_circ_ACAP2	ACAP2	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0,007,331 is up-regulated in breast cancer tissues and PTX-resistant breast cancer cell lines. It promotes PTX resistance, proliferation, cell cycle progression, migration, invasion and xenograft tumor growth while inhibiting apoptosis, at least partly by sponging miR-200b-3p to increase ANLN expression."	0.8298
35929525	Histology and histopathology	2023	"Circ_0000467 regulates proliferation, migration, invasion, and apoptosis in gastric cancer by targeting the miR-622/ROCK2 axis."	hsa_circ_0000467	circ_0000467	hsa_circ_SKA3	SKA3	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_0000467 is up-regulated in gastric cancer tissues and cells and acts as an oncogenic circRNA. It promotes proliferation, migration, invasion, and tumor growth while inhibiting apoptosis by sponging miR-622 and increasing ROCK2 expression. The study suggests circ_0000467 may have diagnostic or therapeutic relevance in GC."	0.8298
35930171	Biochemical genetics	2023	Exosomal circKDM4A Induces CUL4B to Promote Prostate Cancer Cell Malignancy in a miR-338-3p-Dependent Manner.	hsa_circ_0012098	circ_0012098 / Circular RNA lysine demethylase 4A	hsa_circ_KDM4A	KDM4A	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"Exosomal circKDM4A is up-regulated in serum exosomes, tissues and cells from prostate cancer. It promotes malignant phenotypes including proliferation, migration, invasion and xenograft tumor growth while suppressing apoptosis, mainly through a circKDM4A/miR-338-3p/CUL4B regulatory axis."	0.8299
35934785	Bioscience trends	2022	Hepatic stellate cell exosome-derived circWDR25 promotes the progression of hepatocellular carcinoma via the miRNA-4474-3P-ALOX-15 and EMT axes.		circWDR25 / hsa_circ_004310	hsa_circ_WDR25	WDR25	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"This study identifies HSC-derived exosomal circWDR25 as an oncogenic circRNA in HCC. circWDR25 promotes HCC proliferation, migration, invasion, tumor growth, EMT, and immune checkpoint-related PD-L1/CTLA-4 expression mainly through the circWDR25/miR-4474-3p/ALOX15 regulatory axis. Clinically, high peritumoral circWDR25 expression is associated with poor OS and RFS and may serve as a prognostic biomarker."	0.8191
35940521	Journal of genetics and genomics = Yi chuan xue bao	2023	Hsa_Circ_0000826 inhibits the proliferation of colorectal cancer by targeting AUF1.	hsa_circ_0000826	Circ_0000826	hsa_circ_ANKRD12	ANKRD12	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR; ISH; RNA-seq; Microarray	"Circ_0000826 is down-regulated in colorectal cancer tissues and low expression is associated with worse patient prognosis. Functionally, Circ_0000826 suppresses CRC cell proliferation in vitro and in a xenograft model. Mechanistically, it binds the RNA-binding protein AUF1 and competes with the c-MYC mRNA 3 0 -UTR for AUF1 binding, thereby reducing c-MYC protein expression and tumor proliferation."	0.8939
35946541	Anti-cancer drugs	2022	Circ_0001058 represses the progression of lung adenocarcinoma through governing of the miR-486-5p/TEK signaling axis.	hsa_circ_0001058	circ_0001058	hsa_circ_RNF149		lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR	"Circ_0001058 is downregulated in lung adenocarcinoma tissues and cell lines and predominantly localizes in the cytoplasm. Its overexpression suppresses malignant phenotypes, including proliferation, survival, invasion and in vivo tumor growth, while promoting apoptosis. Mechanistically, circ_0001058 targets miR-486-5p and modulates the downstream TEK signaling axis."	0.7785
35946546	Anti-cancer drugs	2022	Circular RNA circVPRBP serves as a microRNA-106b-5p sponge to regulate proliferation and metastasis of cervical cancer cells via tripartite motif-containing protein 3.	hsa_circ_0065898	circRNA DDB1-and CUL4-associated factor 1 / circVPRBP	hsa_circ_VPRBP	VPRBP	cervical cancer / CC	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR; Microarray	"CircVPRBP/hsa_circ_0065898 is down-regulated in cervical cancer tissues and cell lines. It functions as a tumor suppressive circRNA by sponging miR-106b-5p to increase TRIM3 expression, thereby inhibiting proliferation, cell cycle progression, migration, invasion, metastasis, and in vivo tumor growth while promoting apoptosis. The study suggests circVPRBP may be a potential therapeutic target for cervical cancer."	0.8207
35946568	Anti-cancer drugs	2022	Identification of exosomal circRNA CD226 as a potent driver of nonsmall cell lung cancer through miR-1224-3p/high mobility group AT-hook 2 axis.	hsa_circ_0047921	circRNA CD226	hsa_circ_CD226	CD226	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circCD226 is up-regulated in NSCLC serum exosomes, tumor tissues and cell lines, and high expression is associated with poorer survival and diagnostic potential. Functionally, circCD226 promotes NSCLC cell viability, proliferation, migration, invasion, stemness and xenograft tumor growth. Mechanistically, it acts as a ceRNA by sponging miR-1224-3p to up-regulate HMGA2."	0.8791
35947965	Gynecologic and obstetric investigation	2022	Circ_0061140 Facilitates Adenomyosis Progression by Upregulating LIN28B in vitro.	hsa_circ_0061140	circ_0061140	hsa_circ_C20orf11	C20orf11	adenomyosis	MONDO:0010888	adenomyosis	up-regulated	RT-qPCR	"circ_0061140 is up-regulated in endometrial tissues from adenomyosis patients and mainly localized in the cytoplasm of endometrial epithelial cells. Functionally, it promotes adenomyosis-associated cell viability, proliferation, migration and invasion while suppressing apoptosis. Mechanistically, circ_0061140 sponges miR-141-3p to up-regulate LIN28B, forming a circ_0061140/miR-141-3p/LIN28B regulatory axis with potential therapeutic relevance."	0.7799
35958507	American journal of translational research	2022	Hsa_circular RNA_0001013 exerts oncogenic effects in gastric cancer through the microRNA-136-TWSG1 axis.	hsa_circ_0001013	circ_0001013			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001013 is upregulated in gastric cancer tissues and cell lines and its high expression is associated with poor patient survival. Functionally, it promotes proliferation, migration, invasion, cell cycle progression and xenograft tumor growth while inhibiting apoptosis. Mechanistically, hsa_circ_0001013 binds miR-136 and increases TWSG1 expression through a circRNA-miRNA-mRNA regulatory axis."	0.8192
35960460	Metabolic brain disease	2022	Circ_0003611 regulates apoptosis and oxidative stress injury of Alzheimer's disease via miR-383-5p/KIF1B axis.	hsa_circ_0003611				Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR	"circ_0003611 is up-regulated in serum from AD patients and in Abeta-treated SH-SY5Y and SK-N-SH cells. It promotes Abeta-triggered neuronal injury by sponging miR-383-5p and regulating KIF1B expression, thereby affecting proliferation, apoptosis, oxidative stress, inflammatory response, and glycolysis-related phenotypes. The study suggests circ_0003611 may serve as a potential diagnostic marker and therapeutic target for AD."	0.6996
35974445	Endocrinology	2022	Circulating Exosomal circRNA_0063476 Impairs Expression of Markers of Bone Growth Via the miR-518c-3p/DDX6 Axis in ISS.	hsa_circ_0063476				Idiopathic short stature / ISS	MONDO:1010112	isolated short stature	up-regulated	RT-qPCR; Microarray	"This study identifies exosomal hsa_circ_0063476 as an up-regulated plasma exosomal circRNA in children with ISS. Mechanistically, hsa_circ_0063476 acts through the miR-518c-3p/DDX6 axis to promote chondrocyte apoptosis and inhibit proliferation, hypertrophy, and endochondral ossification, thereby impairing longitudinal bone growth and contributing to a short stature phenotype."	0.7993
35978501	International immunopharmacology	2022	Depletion of circ_0128846 ameliorates interleukin-1beta-induced human chondrocyte apoptosis and inflammation through the miR-940/PTPN12 pathway.	hsa_circ_0128846		hsa_circ_ZFX	ZFX	osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circ_0128846 is up-regulated in OA cartilage tissues and IL-1beta-treated human C28/I2 chondrocytes. It promotes OA-like chondrocyte injury by sponging miR-940 to increase PTPN12 expression, thereby inhibiting proliferation and promoting apoptosis and inflammation. Its depletion ameliorates IL-1beta-induced chondrocyte damage, suggesting therapeutic relevance in osteoarthritis."	0.7795
35988709	Fish & shellfish immunology	2022	"Circular RNA circRara promote the innate immune responses in miiuy croaker, Miichthys miiuy."		circRara		Rara	bacterial and viral infection	MONDO:0000001	disease	up-regulated	RT-qPCR; RNA-seq	"circRara is a newly identified Rara-derived circular RNA in miiuy croaker that is up-regulated after LPS or poly (I:C) immune stimulation. It positively regulates antibacterial and antiviral innate immune responses by enhancing NF-kappaB/IRF3-related reporter activity and increasing inflammatory cytokines and antiviral genes, while also promoting cell viability and proliferation."	0.7323
35988930	Journal of physiology and pharmacology : an official journal of the Polish Physiological Society	2022	Curcumin suppresses colorectal cancer development with epithelial-mesenchymal transition via modulating circular RNA HN1/miR-302a-3p/PIK3R3 axis.		circular RNA (circ) HN1 / circHN1	hsa_circ_HN1	HN1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circHN1 is up-regulated in human CRC tissues and cell lines and its high expression is associated with advanced clinical features and poor overall survival. Functionally, circHN1 promotes CRC malignant phenotypes and weakens curcumin-mediated antitumor effects by sponging miR-302a-3p and regulating PIK3R3."	0.8005
35997022	"Hypertension (Dallas, Tex. : 1979)"	2022	Reduced CircSMOC1 Level Promotes Metabolic Reprogramming via PTBP1 (Polypyrimidine Tract-Binding Protein) and miR-329-3p in Pulmonary Arterial Hypertension Rats.	rno_circ_0032358	circSMOC1	rno_circ_SMOC1	SMOC1	pulmonary arterial hypertension / PAH	MONDO:0015924	pulmonary arterial hypertension	down-regulated	RT-qPCR; ISH; RNA-seq	"circSMOC1 is downregulated in pulmonary arteries and PASMCs of PAH rat models. Its reduction promotes PASMC proliferation, migration, aerobic glycolysis and mitochondrial dysfunction through nuclear PTBP1/PKM splicing regulation and cytoplasmic miR-329-3p/PDHB regulation, while circSMOC1 overexpression alleviates pulmonary vascular remodeling in vivo."	0.7923
35998475	Ecotoxicology and environmental safety	2022	Rno_circRNA_008646 regulates formaldehyde induced lung injury through Rno-miR-224 mediated FOXI1/CFTR axis.		rno_circRNA_008646	rno_circ_ASH1L	ASH1L	formaldehyde-induced lung injury	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR; Microarray	"This study reports that rno_circRNA_008646 is up-regulated in rat lung tissues after formaldehyde exposure and positively correlates with lung injury severity. Mechanistically, rno_circRNA_008646 binds rno-miR-224 and relieves suppression of FOXI1, leading to increased CFTR expression and contributing to formaldehyde-induced lung injury."	0.6683
36004692	Critical reviews in eukaryotic gene expression	2022	ciRS-7 Enhances the Progression of Hepatocellular Carcinoma through miR-944/NOX4 Pathway.		ciRS-7 / Cdr1as	hsa_circ_CDR1	CDR1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"ciRS-7 is upregulated in hepatocellular carcinoma cells and tumor tissues. It promotes HCC proliferation, migration, and invasion by acting as a sponge for miR-944, thereby increasing NOX4 expression. The study proposes ciRS-7 and the ciRS-7/miR-944/NOX4 axis as potential therapeutic targets for HCC."	0.7795
36017647	Immunopharmacology and immunotoxicology	2023	CircRNA circ-PDCD11 is highly expressed in lung large-cell carcinoma and predicts poor survival.	hsa_circ_0019853	Circ-PDCD11	hsa_circ_PDCD11	PDCD11	lung large cell carcinoma / LLCC	MONDO:0003050	lung large cell carcinoma	up-regulated	RT-qPCR	"This study found that circ-PDCD11/hsa_circ_0019853 is specifically up-regulated in plasma and tumor tissues from LLCC patients, but not in other lung cancer subtypes. Higher plasma circ-PDCD11 levels distinguish LLCC from other lung cancers and healthy controls, correlate with metastasis, and predict poor survival, supporting its value as a diagnostic and prognostic biomarker."	0.4992
36017856	Protein and peptide letters	2022	Circ_0006789 Promotes the Progression of Hepatocellular Carcinoma Cells via Modulating miR-1324 and SOX12.	hsa_circ_0006789				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0006789/circ_0006789 is up-regulated in HCC tissues and cell lines. It promotes HCC cell growth, migration and invasion, functioning as an oncogenic circRNA. Mechanistically, circ_0006789 sponges miR-1324 to increase SOX12 expression through a circ_0006789/miR-1324/SOX12 ceRNA axis."	0.7477
36017914	Critical reviews in eukaryotic gene expression	2022	circHIPK2 Has a Potentially Important Clinical Significance in Colorectal Cancer Progression via HSP90 Ubiquitination by miR485-5p.			hsa_circ_HIPK2	HIPK2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq; Microarray	"circHIPK2 is upregulated in CRC tissues and cell lines and high expression is associated with poorer overall and disease-free survival. Functionally, circHIPK2 promotes CRC cell proliferation and migration, likely through a cytoplasmic circHIPK2/miR-485-5p/HSP90 regulatory mechanism involving HSP90 ubiquitination. The study proposes circHIPK2 as a potential diagnostic/prognostic biomarker and therapeutic target for CRC."	0.7357
36030691	International immunopharmacology	2022	Circular RNA circESPL1 knockdown alleviates lipopolysaccharide (LPS)-induced lung cell injury via sponging miR-326 to regulate MAPK14.	hsa_circ_0026579		hsa_circ_ESPL1	ESPL1	infantile pneumonia / IP	MONDO:0005249	pneumonia	up-regulated	RT-qPCR	"In this study, hsa_circ_0026579/circESPL1 was up-regulated in serum from IP patients and in LPS-treated WI-38 and MRC-5 lung cells. Silencing circESPL1 alleviated LPS-induced lung cell injury by improving proliferation and reducing apoptosis and inflammatory cytokine secretion. Mechanistically, circESPL1 acted as a cytoplasmic ceRNA sponge for miR-326 to regulate MAPK14."	0.8119
36036266	Journal of molecular evolution	2022	The Sponge Interaction Between Circular RNA and microRNA Serves as a Fast-Evolving Mechanism That Suppresses Non-small Cell Lung Cancer (NSCLC) in Humans.	hsa_circ_0003497		hsa_circ_WDPCP	WDPCP	Non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"This study identifies hsa_circ_0003497 as a down-regulated circRNA in NSCLC with a tumor-suppressive role. Mechanistically, hsa_circ_0003497 is proposed to sponge miR-197-3p, thereby relieving suppression of the tumor suppressor gene CTNND1 and inhibiting NSCLC cell growth."	0.5545
36048566	Clinical and experimental pharmacology & physiology	2023	Hsa_circ_0001204 modulates inflammatory response of macrophages infected by Mycobacterium tuberculosis via TLR4/NF-kappaB signalling pathway.	hsa_circ_0001204		hsa_circ_DGCR8	DGCR8	tuberculosis / TB	MONDO:0018076	tuberculosis	down-regulated	RT-qPCR	"hsa_circ_0001204 is downregulated in serum from TB patients and in M.tb-infected THP-1 macrophages. Its overexpression reduces intracellular M.tb survival and mitigates macrophage apoptosis and inflammatory cytokine production, likely by suppressing TLR4/NF-kappaB pathway activation. The study suggests hsa_circ_0001204 may have therapeutic potential for TB prevention."	0.6593
36049358	Biochemical and biophysical research communications	2022	Circular RNA circMET contributes to tamoxifen resistance of breast cancer cells by targeting miR-204/AHR signaling.		circMET	hsa_circ_MET	MET	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circMET is up-regulated in tamoxifen-resistant breast cancer cells and clinical tamoxifen-resistant samples. It promotes tamoxifen resistance, cell viability, and proliferation by acting through the miR-204-5p/AHR axis, suggesting potential value as an indicator of tamoxifen response and a therapeutic target."	0.7507
36054164	Environmental and molecular mutagenesis	2022	CircRNA RNF10 inhibits tumorigenicity by targeting miR-942-5p/GOLIM4 axis in breast cancer.	hsa_circ_0028899	circ_RNF10	hsa_circ_RNF10		breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	"Circ_RNF10 (hsa_circ_0028899), derived from RNF10, is down-regulated in breast cancer tissues and cells. Restoring circ_RNF10 suppresses malignant breast cancer phenotypes by inhibiting proliferation, migration, invasion and xenograft tumor growth while promoting apoptosis. Mechanistically, circ_RNF10 functions as a ceRNA for miR-942-5p to upregulate GOLIM4."	0.7956
36057815	Clinical hemorheology and microcirculation	2023	Circ_0091822 aggravates ox-LDL-induced endothelial cell injury through targeting the miR-661/RAB22A axis.	hsa_circ_0091822	Circ_0091822			atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"circ 0091822 is up-regulated in atherosclerosis serum samples and ox-LDL-induced HUVECs. It aggravates endothelial cell injury by promoting inflammation and apoptosis while inhibiting proliferation, at least partly through the miR-661/RAB22A regulatory axis. Its overexpression in AS suggests potential value as a biomarker or therapeutic target."	0.7177
36058014	"Pathology, research and practice"	2022	Circ_0027446 induces CLDN1 expression to promote papillary thyroid cancer cell malignancy by binding to miR-129-5p.	hsa_circ_0027446	Circ_0027446	hsa_circ_HMGA2	HMGA2	papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0027446 is upregulated in papillary thyroid cancer tissues and cells and functions as an oncogenic circRNA. It promotes PTC proliferation, migration, invasion and xenograft tumor growth while suppressing apoptosis, mainly by sponging miR-129-5p to increase CLDN1 expression. High circ_0027446 expression is associated with poor patient survival and may have diagnostic and therapeutic relevance."	0.7987
36058431	Pharmacological research	2022	Oxidant stress-sensitive circRNA Mdc1 controls cardiomyocyte chromosome stability and cell cycle re-entry during heart regeneration.		circRNA 30491	mmu_circ_Mdc1	Mdc1	myocardial infarction / MI	MONDO:0005068	myocardial infarction	down-regulated	RT-qPCR; Microarray	"circMdc1 is an oxidative stress-sensitive mouse circRNA derived from Mdc1 that is upregulated during postnatal heart development and downregulated in regenerative myocardium. It suppresses cardiomyocyte proliferation and cell cycle re-entry by binding PABP and blocking Mdc1 translation, thereby increasing DNA damage, chromosomal instability, and ATR signaling. In vivo circMdc1 knockdown promotes cardiac regeneration and improves heart repair after myocardial infarction, whereas circMdc1 overexpression impairs neonatal heart repair."	0.853
36066383	Anti-cancer drugs	2022	Hsa_circ_0000877 facilitates the progression of diffuse large B-cell lymphoma by miR-370-3p/mitogen-activated protein kinase kinase kinase kinase 4/Hippo pathway.	hsa_circ_0000877	circ_0000877			diffuse large B-cell lymphoma	MONDO:0018905	diffuse large B-cell lymphoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000877/circ_0000877 is up-regulated in DLBCL tissues and cell lines. It promotes malignant DLBCL phenotypes by sponging miR-370-3p, increasing MAP4K4 expression and activating the Hippo pathway; its knockdown suppresses proliferation, migration, invasion and xenograft tumor growth while promoting apoptosis and G0/G1 arrest."	0.8256
36066393	Anti-cancer drugs	2022	Circular RNA circ_0007841 participates in progression of nonsmall cell lung cancer via miR-199a-5p/SphK2 axis.	hsa_circ_0007841	circ_0007841	hsa_circ_SEC61A1	SEC61A1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0007841 is up-regulated in NSCLC tissues and cell lines and functions as an oncogenic circRNA. Mechanistically, it sponges miR-199a-5p to increase SphK2 expression, thereby promoting NSCLC cell proliferation, migration, invasion, adhesion-related protein changes, and xenograft tumor growth."	0.8443
36066399	Anti-cancer drugs	2023	"CircRNA High Mobility Group At-hook 2 regulates cell proliferation, metastasis and glycolytic metabolism of nonsmall cell lung cancer by targeting miR-331-3p to upregulate High Mobility Group At-hook 2."	hsa_circ_0027446	circRNA High Mobility Group AT-hook 2	hsa_circ_HMGA2	HMGA2	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"CircHMGA2 is up-regulated in NSCLC tissues and cell lines, and high expression is associated with metastasis and poor prognosis. Functionally, circHMGA2 promotes NSCLC proliferation, migration, invasion, tumorigenesis and glycolysis. Mechanistically, circHMGA2 sponges miR-331-3p to increase HMGA2 expression, forming the circHMGA2/miR-331-3p/HMGA2 regulatory axis."	0.8568
36066401	Anti-cancer drugs	2023	circRNA mannosidase alpha class 1A member 2 contributes to the proliferation and motility of papillary thyroid cancer cells through upregulating metadherin via absorbing microRNA-449a.	hsa_circ_0000119	circRNA mannosidase alpha class 1A member 2 	hsa_circ_MAN1A2	MAN1A2	papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circMAN1A2/hsa_circ_0000119 is upregulated in papillary thyroid carcinoma tissues and cell lines. It acts as an oncogenic circRNA that promotes PTC cell proliferation, migration, invasion, EMT and xenograft tumor growth by sponging miR-449a and thereby increasing MTDH expression. The study suggests the circ-MAN1A2/miR-449a/MTDH axis as a potential therapeutic target for PTC."	0.8298
36076572	Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie	2022	Hypoxic ADSC-derived exosomes enhance wound healing in diabetic mice via delivery of circ-Snhg11 and induction of M2-like macrophage polarization.	mmu_circ_0001100	circ-Snhg11	mmu_circ_Snhg11	Snhg11	diabetic wound	MONDO:0005015	diabetes mellitus	down-regulated	RT-qPCR; RNA-seq	"In this study, circ-Snhg11 is a mouse exosomal circRNA decreased under diabetic/high-glucose conditions and enriched in hypoxic ADSC-derived exosomes. Its overexpression protects EPCs from HG-induced dysfunction, promotes angiogenesis and M2-like macrophage polarization, and accelerates diabetic wound healing through the miR-144-3p/HIF-1alpha/VEGF and miR-144-3p/HIF-1alpha/STAT3 signaling axes."	0.7595
36106650	Histology and histopathology	2023	Circular RNA circ-CD44 regulates chemotherapy resistance by targeting the miR-330-5p/ABCC1 axis in colorectal cancer cells.	hsa_circ_0000291	circ-CD44 / hsa-circRNA-000792	hsa_circ_CD44	CD44	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"Circ-CD44 is upregulated in colorectal cancer, especially in oxaliplatin-resistant CRC tissues and cells. It promotes oxaliplatin resistance and malignant phenotypes by sponging miR-330-5p and restoring ABCC1 expression, while circ-CD44 silencing increases OXA sensitivity, induces apoptosis, and suppresses proliferation, migration, invasion, and xenograft tumor growth."	0.705
36107285	Molecular and cellular biochemistry	2023	circANKRD17(has_circ_0007883) confers paclitaxel resistance of ovarian cancer via interacting with FUS to stabilize FOXR2.	hsa_circ_0007883	circANKRD17	hsa_circ_ANKRD17	ANKRD17	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR; Microarray	"circANKRD17 is up-regulated in ovarian cancer, especially PTX-resistant tissues and cell lines, and high expression is associated with poorer overall survival. It promotes paclitaxel chemoresistance and tumor growth by interacting with the RNA-binding protein FUS to stabilize FOXR2 mRNA and increase FOXR2 expression."	0.8743
36110046	Molecular therapy : the journal of the American Society of Gene Therapy	2023	A protein encoded by circular ZNF609 RNA induces acute kidney injury by activating the AKT/mTOR-autophagy pathway.		circ-ZNF609	hsa_circ_ZNF609	ZNF609	acute kidney injury / AKI	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR; ISH; RNA-seq	"circ-ZNF609 is up-regulated in ischemic AKI kidney tissues and in urinary samples from AKI patients. It encodes the 250-aa protein ZNF609-250aa, which activates AKT3/mTOR signaling, impairs autophagic flux, promotes renal tubular epithelial cell apoptosis, suppresses proliferation, and contributes to AKI; urinary circ-ZNF609 also shows moderate diagnostic potential for AKI."	0.8441
36110046	Molecular therapy : the journal of the American Society of Gene Therapy	2023	A protein encoded by circular ZNF609 RNA induces acute kidney injury by activating the AKT/mTOR-autophagy pathway.		circ-ZNF609	rno_circ_ZNF609	ZNF609	acute kidney injury / AKI	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR; ISH; RNA-seq	"circ-ZNF609 is up-regulated in ischemic AKI kidney tissues and in urinary samples from AKI patients. It encodes the 250-aa protein ZNF609-250aa, which activates AKT3/mTOR signaling, impairs autophagic flux, promotes renal tubular epithelial cell apoptosis, suppresses proliferation, and contributes to AKI; urinary circ-ZNF609 also shows moderate diagnostic potential for AKI."	0.8441
36125054	Histology and histopathology	2023	Circ_0031242 regulates the functional properties of hepatocellular carcinoma cells through the miR-944/MAD2L1 axis.	hsa_circ_0031242	circ_0031242	hsa_circ_PRMT5	PRMT5	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0031242 is up-regulated in HCC tissues and HCC cell lines. It promotes malignant HCC cell behaviors including proliferation, migration, invasion, glycolysis and xenograft tumor growth, while suppressing apoptosis. Mechanistically, circ_0031242 functions through a miR-944/MAD2L1 regulatory axis."	0.7662
36134741	Histology and histopathology	2023	Circular RNA circ_SKA3 enhances gastric cancer development by targeting miR-520h.	hsa_circ_0000467	circ_SKA3	hsa_circ_SKA3	SKA3	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_SKA3 is overexpressed in gastric cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation, cell cycle progression, colony formation, migration, invasion and xenograft tumor growth while suppressing apoptosis, at least partly by directly binding miR-520h and relieving repression of CDC42."	0.8071
36135340	Oral diseases	2024	Circ-OMAC drives metastasis in oral squamous cell carcinoma.	hsa_circ_0001900	circ-OMAC / circ-oral cancer metastasis-associated circRNA	hsa_circ_OMAC	OMAC	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circ-OMAC, identified as hsa_circ_0001900, is up-regulated in metastatic lymph nodes from OSCC patients and high expression indicates poor prognosis. Functionally, circ-OMAC promotes OSCC migration, invasion and in vivo metastasis by activating EMT signaling, involving Twist and EMT marker changes. The study supports circ-OMAC as a potential therapeutic target and prognostic biomarker for oral cancer."	0.8145
36136987	Anti-cancer drugs	2022	Exosomal circRNA Scm-like with four malignant brain tumor domains 2 (circ-SFMBT2) enhances the docetaxel resistance of prostate cancer via the microRNA-136-5p/tribbles homolog 1 pathway.	hsa_circ_0017649	circRNA Scm-like with four malignant brain tumor domains 2 / circ-SFMBT2	hsa_circ_SFMBT2	SFMBT2	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circSFMBT2 is up-regulated in docetaxel-resistant prostate cancer cells and in serum exosomes from docetaxel-resistant prostate cancer patients. It is transferred via exosomes and promotes docetaxel resistance, proliferation, migration and invasion while inhibiting apoptosis. Mechanistically, circSFMBT2 sponges miR-136-5p to up-regulate TRIB1, and it shows potential diagnostic and therapeutic relevance for docetaxel-resistant prostate cancer."	0.8596
36136988	Anti-cancer drugs	2022	Circ_0039569 contributes to the paclitaxel resistance of endometrial cancer via targeting miR-1271-5p/PHF6 pathway.	hsa_circ_0039569	Circ_0039569	hsa_circ_CCL22	CCL22	endometrial cancer / EC	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR	"Circ_0039569 is up-regulated in paclitaxel-resistant endometrial cancer tissues and cells. It promotes paclitaxel resistance by acting as a sponge for miR-1271-5p and increasing PHF6 expression, thereby enhancing cell growth and invasion and reducing drug sensitivity. Knockdown of circ_0039569 improves paclitaxel sensitivity in vitro and in cell line-derived xenograft tumors."	0.8175
36136989	Anti-cancer drugs	2022	Circ_0005615 contributes to the progression and Bortezomib resistance of multiple myeloma by sponging miR-185-5p and upregulating IRF4.	hsa_circ_0005615	circ_0005615	hsa_circ_NFATC3	NFATC3	multiple myeloma / MM	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR	"Circ_0005615 is up-regulated in multiple myeloma tissues and cell lines and acts as an oncogenic circRNA. It promotes proliferation, cell cycle progression, tumor growth, and bortezomib resistance while suppressing apoptosis. Mechanistically, circ_0005615 sponges miR-185-5p to upregulate IRF4, forming a circ_0005615/miR-185-5p/IRF4 regulatory axis."	0.7949
36136992	Anti-cancer drugs	2022	Circ_0002111 modulates the growth process of papillary thyroid carcinoma cells by targeting the miR-363-3p/HMGB1 axis.	hsa_circ_0002111	circ_0002111	hsa_circ_PSD3	PSD3	papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circ_0002111 is up-regulated in papillary thyroid carcinoma tissues and cells and acts as an oncogenic circRNA. Its knockdown suppresses PTC cell viability, proliferation, invasion, angiogenesis/tube formation and xenograft tumor growth while promoting apoptosis. Mechanistically, circ_0002111 sponges miR-363-3p to regulate HMGB1 expression, forming a circ_0002111/miR-363-3p/HMGB1 axis with potential therapeutic relevance."	0.7662
36153002	The Journal of pharmacology and experimental therapeutics	2023	CircRNA_33702 Promotes Renal Fibrosis by Targeting the miR-29b-3p/WNT1-Inducible Signaling Pathway Protein 1 Pathway.		CircRNA_33702 / mmu_circ_33702			renal fibrosis	MONDO:0000494	renal fibrosis	up-regulated	RT-qPCR; Microarray	"Mouse circRNA_33702 is up-regulated in UUO-induced renal fibrosis and TGF-b1-treated BUMPT cells. It promotes renal fibrosis by sponging miR-29b-3p and increasing WISP1 expression, thereby enhancing ECM-related proteins including collagen I, collagen III, and fibronectin."	0.692
36153002	The Journal of pharmacology and experimental therapeutics	2023	CircRNA_33702 Promotes Renal Fibrosis by Targeting the miR-29b-3p/WNT1-Inducible Signaling Pathway Protein 1 Pathway.	hsa_circ_0026331				renal fibrosis	MONDO:0000494	renal fibrosis	up-regulated	RT-qPCR	"Human hsa_circ_0026331, a homolog of mouse circRNA_33702, is up-regulated in TGF-b1-treated HK-2 cells. Its knockdown reduces TGF-b1-induced collagen I, collagen III, and fibronectin expression, supporting a profibrotic role and potential therapeutic relevance in renal fibrosis."	0.3513
36161300	Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences	2022	Effect of circPUM1 on radioresistance of cervical cancer cells through targeting miR-144-3p.		circPUM1 / circular RNA pumilio RNA binding family member (circPUM) 1	hsa_circ_PUM1	PUM1	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circPUM1 is up-regulated in cervical cancer tissues and is negatively correlated with miR-144-3p expression. Functional experiments indicate that circPUM1 promotes radioresistant malignant phenotypes, including proliferation, colony formation, migration and invasion, while suppressing apoptosis. Mechanistically, circPUM1 acts through targeting/regulating miR-144-3p and affects cleaved-caspase3-associated apoptosis."	0.6536
36164699	Zhonghua zhong liu za zhi [Chinese journal of oncology]	2022	[CircRNA circTNPO1 promotes the proliferation and metastasis of osteosarcoma by sponging miR-338-3p].		circTNPO1	hsa_circ_TNPO1	TNPO1	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circTNPO1 is up-regulated in osteosarcoma cell lines compared with human osteoblast cells. It promotes osteosarcoma proliferation, migration, metastasis-related phenotypes, and xenograft tumor growth by sponging miR-338-3p and regulating Ki-67 and Vimentin expression, suggesting it may be a therapeutic target for osteosarcoma."	0.6479
36178207	Histology and histopathology	2023	The circCDK17/miR-122-5p/ASF1B axis regulates the progression of cervical cancer.	hsa_circ_0002762	circCDK17	hsa_circ_CDK17	CDK17	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; Microarray	"circCDK17 is up-regulated in cervical cancer tissues and cells and functions as an oncogenic circRNA. It promotes proliferation, cell cycle progression, migration, invasion, and tumor growth by acting as a ceRNA for miR-122-5p and increasing ASF1B expression. Its expression is associated with clinicopathologic features and may have diagnostic or therapeutic relevance in cervical cancer."	0.8175
36181561	Odontology	2023	Hsa_circ_0081069 facilitates tongue squamous cell carcinoma progression by modulating MAP2K4 expression via miR-634.	hsa_circ_0081069	circ_0081069	hsa_circ_COL1A2	COL1A2	tongue squamous cell carcinoma / TSCC	MONDO:0000500	tongue squamous cell carcinoma	up-regulated	RT-qPCR	"circ_0081069 is up-regulated in TSCC tissues and cells and acts as an oncogenic circRNA. It promotes TSCC cell proliferation, cell cycle progression, migration, invasion, EMT-related marker changes, and xenograft tumor growth through the miR-634/MAP2K4 axis. The study suggests circ_0081069 may be a potential diagnostic biomarker and therapeutic target for TSCC."	0.8005
36191606	Chemico-biological interactions	2022	Hsa_circ_0007478 aggravates NLRP3 inflammasome activation and lipid metabolism imbalance in ox-LDL-stimulated macrophage via miR-765/EFNA3 axis.	hsa_circ_0007478				atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR; Microarray	"hsa_circ_0007478 is up-regulated in ox-LDL-stimulated THP-1-derived macrophages and is localized in the cytoplasm. It promotes NLRP3 inflammasome activation, inflammatory cytokine expression, ox-LDL uptake, lipid metabolism imbalance, and foam cell formation by sponging miR-765 and increasing EFNA3 expression. The study suggests hsa_circ_0007478 as a potential therapeutic target for alleviating atherosclerotic progression."	0.7442
36193940	Histology and histopathology	2023	CircTADA2A up-regulates MAPK8 by targeting MiR-214-3p and recruiting EIF4A3 to promote the invasion and migration of non-small cell lung cancer cells.		CircTADA2A / hsa_circRNA_102051	hsa_circ_TADA2A	TADA2A	Non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circTADA2A is highly expressed in NSCLC cells and functions as an oncogenic circRNA that promotes migration and invasion. Mechanistically, it up-regulates MAPK8 through two routes: sponging miR-214-3p in a ceRNA manner and recruiting the RBP EIF4A3 to stabilize MAPK8 mRNA."	0.7785
36194985	International immunopharmacology	2022	"Circ_0022383 alleviates IL-1beta-induced apoptosis, inflammation and extracellular matrix degeneration in osteoarthritis cell model by miR-3619-5p/SIRT1 axis."	hsa_circ_0022383	circ_0022383	hsa_circ_FADS2	FADS2	osteoarthritis / OA	MONDO:0005178	osteoarthritis	down-regulated	RT-qPCR	"Circ_0022383 is down-regulated in OA cartilage and IL-1beta-induced human primary chondrocytes. Its overexpression protects chondrocytes by promoting proliferation and suppressing apoptosis, inflammation, and ECM degradation through a circ_0022383/miR-3619-5p/SIRT1 ceRNA axis."	0.8275
36198257	Gynecologic and obstetric investigation	2022	Downregulation of Circ_0088196 Contributes to the Development of Trophoblastic Cells through miR-133b Sponging Function to Affect the AHNAK Expression.	hsa_circ_0088196	circ_0088196	hsa_circ_TNC	TNC	Preeclampsia / PE	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR	"circ_0088196 is upregulated in placental tissues from PE patients and is mainly localized in the cytoplasm of HTR-8/SVneo cells. Functionally, circ_0088196 knockdown promotes trophoblast proliferation, cell cycle progression, migration, and invasion while reducing apoptosis. Mechanistically, circ_0088196 sponges miR-133b to increase AHNAK expression, forming a circ_0088196/miR-133b/AHNAK axis involved in PE progression."	0.8278
36202171	"Brain, behavior, and immunity"	2023	CircNf1-mediated CXCL12 expression in the spinal cord contributes to morphine analgesic tolerance.		rat_circ:chr10:66770890-66783965 / circNf1	rno_circ_Nf1	Nf1	morphine tolerance	MONDO:0005530	opiate dependence	up-regulated	RT-qPCR; RNA-seq	circNf1 is a rat spinal dorsal horn circRNA derived from Nf1 that is up-regulated during chronic morphine-induced analgesic tolerance. It promotes morphine analgesic tolerance by sponging miR-330-3p and miR-665 and by enhancing CXCL12 expression at transcriptional and translational levels; circNf1 knockdown alleviates tolerance in behavioral tests.	0.8473
36206095	Anti-cancer drugs	2022	Blocking circ_0010235 suppresses acquired paclitaxel resistance of non-small cell lung cancer by sponging miR-512-5p to modulate FAM83F expression.	hsa_circ_0010235	circ_0010235	hsa_circ_ALDH4A1	ALDH4A1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0010235 is upregulated in NSCLC and especially in PTX-resistant NSCLC tissues and cells. It promotes paclitaxel resistance and malignant phenotypes by sponging miR-512-5p to increase FAM83F expression, while knockdown of circ_0010235 improves PTX sensitivity in vitro and in a xenograft model."	0.7859
36206097	Anti-cancer drugs	2022	"Exosomal circPRRX1 functions as a ceRNA for miR-596 to promote the proliferation, migration, invasion, and reduce radiation sensitivity of gastric cancer cells via the upregulation of NF-kappaB activating protein."	hsa_circ_0004370	circPRRX1 / hsa_circRNA_100385	hsa_circ_PRRX1	PRRX1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circPRRX1 is up-regulated in human gastric cancer tissues and cell lines and can be transferred via exosomes derived from gastric cancer cells. Exosomal circPRRX1 promotes proliferation, colony formation, migration, invasion, and in vivo tumor growth while reducing radiation sensitivity. Mechanistically, it functions as a ceRNA for miR-596 to increase NKAP expression, forming an exosomal circPRRX1/miR-596/NKAP axis."	0.7177
36206102	Anti-cancer drugs	2022	Exosome-mediated transfer of circ_0063526 enhances cisplatin resistance in gastric cancer cells via regulating miR-449a/SHMT2 axis.	hsa_circ_0063526	circ_0063526	hsa_circ_RANGAP1	RANGAP1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circ_0063526 is up-regulated in gastric cancer tissues, cells, CDDP-resistant cells, and serum exosomes from CDDP-resistant patients. It can be transferred via exosomes to CDDP-sensitive gastric cancer cells and promotes cisplatin resistance, migration, invasion, and autophagy by sponging miR-449a and increasing SHMT2 expression. Serum exosomal circ_0063526 is associated with poor response to cisplatin treatment and may have diagnostic biomarker value."	0.7032
36206112	Anti-cancer drugs	2023	Circular RNA circ-AGFG1 contributes to esophageal squamous cell carcinoma progression and glutamine catabolism by targeting microRNA-497-5p/solute carrier family 1 member 5 axis.	hsa_circ_0058514	circRNA ArfGAP with FG repeats 1 (circ-AGFG1) / circ-AGFG1	hsa_circ_AGFG1	AGFG1	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"Circ-AGFG1 is upregulated in ESCC tissues and cell lines and promotes malignant phenotypes, including proliferation, migration, invasion, in vivo tumor growth and glutamine catabolism, while inhibiting apoptosis. Mechanistically, it acts as a ceRNA sponge for miR-497-5p to increase SLC1A5 expression, forming the circ-AGFG1/miR-497-5p/SLC1A5 axis."	0.7662
36206113	Anti-cancer drugs	2023	circUBAP2 inhibits cisplatin resistance in gastric cancer via miR-300/KAT6B axis.		circUBAP2 / circRNA UBAP2	hsa_circ_UBAP2	UBAP2	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"circUBAP2 is downregulated in gastric cancer tissues, cell lines, and CDDP-resistant gastric cancer contexts. Its overexpression suppresses cell viability and cisplatin resistance while promoting apoptosis, functioning mechanistically as a miR-300 sponge that upregulates KAT6B. Clinically, low circUBAP2 expression is associated with shorter overall survival, indicating prognostic and therapeutic relevance in CDDP-resistant gastric cancer."	0.774
36210730	Journal of biosciences	2022	Circ-WDR27 regulates mycobacterial vitality and secretion of inflammatory cytokines in Mycobacterium tuberculosis-infected macrophages via the miR-370-3p/FSTL1 signal network.	hsa_circ_0078738	circ-WDR27	hsa_circ_WDR27	WDR27	tuberculosis / TB	MONDO:0018076	tuberculosis	down-regulated	RT-qPCR	"Circ-WDR27 is a human circRNA downregulated in serum from TB patients and in M.tb-infected THP-1 macrophages. Its overexpression protects macrophages during M.tb infection by reducing bacterial survival and apoptosis while increasing pro-inflammatory cytokine release. Mechanistically, circ-WDR27 sponges miR-370-3p to increase FSTL1 expression, forming a circ-WDR27/miR-370-3p/FSTL1 regulatory axis with potential therapeutic relevance for TB."	0.7785
36213989	Clinical hemorheology and microcirculation	2025	Circ_HECW2 regulates ox-LDL-induced dysfunction of cardiovascular endothelial cells by miR-942-5p/TLR4 axis.	hsa_circ_0057583	Circ_HECW2	hsa_circ_HECW2	HECW2	coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR	"Circ HECW2 is up-regulated in CAD patient serum and ox-LDL-treated hCMECs. Functionally, circ HECW2 aggravates ox-LDL-induced endothelial cell dysfunction by suppressing proliferation and tube formation and promoting apoptosis. Mechanistically, it sponges miR-942-5p to regulate TLR4 expression through the circ HECW2/miR-942-5p/TLR4 axis."	0.8119
36216207	Microbial pathogenesis	2022	Knockdown of circ_0038467 alleviates lipopolysaccharides-induced 16HBE cell injury by regulating the miR-545-3p/TRAF1 axis in neonatal pneumonia.	hsa_circ_0038467	circ_0038467	hsa_circ_UQCRC2	UQCRC2	pneumonia	MONDO:0005249	pneumonia	up-regulated	RT-qPCR	"circ_0038467 is up-regulated in sera from neonatal pneumonia patients and in LPS-treated 16HBE cells. Functionally, circ_0038467 promotes LPS-induced bronchial epithelial cell injury by reducing proliferation and enhancing apoptosis and inflammatory cytokine expression. Mechanistically, circ_0038467 sponges miR-545-3p to increase TRAF1 expression, forming a circ_0038467/miR-545-3p/TRAF1 regulatory axis."	0.7936
36219356	Molecular and cellular biochemistry	2023	CircMAT2B facilitates the progression of head and neck squamous cell carcinoma via sponging miR-491-5p to trigger ASCT2-mediated glutaminolysis.	hsa_circ_0074854	circMAT2B	hsa_circ_MAT2B	MAT2B	head and neck squamous cell carcinoma / HNSCC	MONDO:0010150	head and neck squamous cell carcinoma	up-regulated	RT-qPCR	"circMAT2B is an up-regulated human circRNA in HNSCC tissues and cell lines, and its high expression is associated with poor patient survival. Functionally, it promotes proliferation, migration, invasion and glutaminolysis while suppressing apoptosis, acting through a circMAT2B/miR-491-5p/ASCT2 ceRNA axis."	0.8595
36219357	Molecular and cellular biochemistry	2023	Circ_0082182 upregulates the NFIB level via sponging miR-326 to promote oxaliplatin resistance and malignant progression of colorectal cancer cells.	hsa_circ_0082182	circ_0082182	hsa_circ_FAM71F2	FAM71F2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"Circ_0082182 is up-regulated in oxaliplatin-resistant colorectal cancer tissues and cells. It promotes oxaliplatin resistance and malignant progression by sponging miR-326 and increasing NFIB expression, while circ_0082182 knockdown enhances chemosensitivity and suppresses tumor growth in a xenograft model."	0.786
36222159	Journal of biosciences	2022	circRERE regulates the expression of GBX2 through miR-1299 and ZC3H13/N6-methyladenosine (m6A) to promote growth and invasion of hepatocellular carcinoma cells.	hsa_circ_0009582	circRERE	hsa_circ_RERE	RERE	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circRERE is upregulated in HCC cells and functions as an oncogenic circRNA. It promotes HCC cell viability, growth and invasion while suppressing apoptosis by enhancing GBX2 expression through miR-1299 and by modulating GBX2 m6A modification through ZC3H13."	0.6562
36227499	Journal of endocrinological investigation	2023	Circ_0002111/miR-134-5p/FSTL1 signal axis regulates tumor progression and glycolytic metabolism in papillary thyroid carcinoma cells.	hsa_circ_0002111	circ_0002111 / hsa_cir-cRNA_104565	hsa_circ_PSD3	PSD3	papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0002111 is upregulated in papillary thyroid carcinoma tissues and cells. It promotes PTC proliferation, migration, glycolytic metabolism and xenograft tumor growth by sponging miR-134-5p and increasing FSTL1 expression."	0.7597
36229758	Molecular and cellular biochemistry	2023	"Circ_0060967 facilitates proliferation, migration, and invasion of non-small-cell lung cancer cells by sponging miR-660-3p/UBN2."	hsa_circ_0060967	circ_0060967 / circRAE1	hsa_circ_RAE1	RAE1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0060967 is up-regulated in NSCLC tissues and cell lines, and high expression is associated with grim prognosis, poor TNM stage, and larger tumor size. Functionally, circ_0060967 promotes NSCLC cell viability, proliferation, migration, invasion, and xenograft tumor growth. Mechanistically, it is mainly cytoplasmic and promotes malignant phenotypes by sponging miR-660-3p to increase UBN2 expression."	0.7756
36239525	Journal of Crohn's & colitis	2023	circSMAD4 Promotes Experimental Colitis and Impairs Intestinal Barrier Functions by Targeting Janus Kinase 2 Through Sponging miR-135a-5p.	hsa_circ_0006952	circSMAD4	hsa_circ_SMAD4	SMAD4	Crohn's disease / CD	MONDO:0005011	Crohn disease	up-regulated	RT-qPCR; ISH; Microarray	"circSMAD4 is up-regulated in colon tissues from Crohn's disease patients and in an IL-10 knockout experimental colitis model. It acts mainly in the cytoplasm as a ceRNA that sponges miR-135a-5p to increase JAK2/JAK2-STAT3-related signaling, impair tight junction proteins and barrier integrity, promote epithelial apoptosis and inflammation, and contribute to colitis progression. Inhibition of circSMAD4 by PLGA microsphere-delivered si-circSMAD4 ameliorates experimental colitis and protects intestinal barrier function, suggesting therapeutic potential."	0.8772
36239525	Journal of Crohn's & colitis	2023	circSMAD4 Promotes Experimental Colitis and Impairs Intestinal Barrier Functions by Targeting Janus Kinase 2 Through Sponging miR-135a-5p.		circSMAD4	mmu_circ_SMAD4	SMAD4	Crohn's disease / CD	MONDO:0005011	Crohn disease	up-regulated	RT-qPCR; ISH; Microarray	"circSMAD4 is up-regulated in colon tissues from Crohn's disease patients and in an IL-10 knockout experimental colitis model. It acts mainly in the cytoplasm as a ceRNA that sponges miR-135a-5p to increase JAK2/JAK2-STAT3-related signaling, impair tight junction proteins and barrier integrity, promote epithelial apoptosis and inflammation, and contribute to colitis progression. Inhibition of circSMAD4 by PLGA microsphere-delivered si-circSMAD4 ameliorates experimental colitis and protects intestinal barrier function, suggesting therapeutic potential."	0.8772
36241055	Cellular signalling	2023	Hsa_circ_0000851 promotes PDK1/p-AKT-mediated cell proliferation and migration by regulating miR-1183 in triple-negative breast cancer.	hsa_circ_0000851		hsa_circ_TCF4	TCF4	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000851 is a TCF4-derived circRNA upregulated in breast cancer, particularly TNBC tissues and cell lines. It functions as an oncogenic cytoplasmic ceRNA that sponges miR-1183, increases PDK1 expression, activates p-AKT signaling, and thereby promotes TNBC proliferation, migration, and xenograft tumor growth. Its expression is associated with Ki-67, tumor size, and lymph node metastasis, suggesting potential biomarker and therapeutic-target value."	0.8537
36245125	Molecular therapy : the journal of the American Society of Gene Therapy	2023	Silencing mouse circular RNA circSlc8a1 by circular antisense cA-circSlc8a1 induces cardiac hepatopathy.	mmu_circ_0000823	circSlc8a1	mmu_circ_Slc8a1	Slc8a1	cardiovascular diseases	MONDO:0004995	cardiovascular disorder	dysregulated	RT-qPCR; RNA-seq	"Mouse circSlc8a1 is a highly expressed cardiac circRNA derived from Slc8a1 and is essential for maintaining physiological heart function. Its expression is dynamically altered after TAC-induced pressure overload, and maintaining circSlc8a1 levels protects against cardiac hypertrophy, fibrosis, and heart failure, whereas silencing it causes heart malfunction with secondary hepatic steatosis/cirrhosis. Mechanistically, circSlc8a1 translocates to mitochondria, binds mitochondrial proteins, facilitates mitochondrial protein import, and promotes ATP production."	0.8174
36247236	American journal of translational research	2022	"The integrative network of circRNA, miRNA and mRNA of epicardial adipose tissue in patients with atrial fibrillation."	hsa_circ_0099634				atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0099634 was one of the top up-regulated circRNAs in epicardial adipose tissue from atrial fibrillation patients and was included among six candidate circRNAs verified by RT-qPCR. Its functional relevance was predicted through a circRNA-miRNA-mRNA network, but no circRNA-specific functional experiment was reported."	0.4032
36247236	American journal of translational research	2022	"The integrative network of circRNA, miRNA and mRNA of epicardial adipose tissue in patients with atrial fibrillation."	hsa_circ_0000932		hsa_circ_SUPT5H	SUPT5H	atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000932, generated from SUPT5H, was up-regulated in epicardial adipose tissue from atrial fibrillation patients and verified as one of six candidate circRNAs by RT-qPCR. The study predicted that it may function in a ceRNA network by interacting with miRNAs and regulating target mRNAs relevant to cardiovascular disorders."	0.4032
36247236	American journal of translational research	2022	"The integrative network of circRNA, miRNA and mRNA of epicardial adipose tissue in patients with atrial fibrillation."	hsa_circ_0097669		hsa_circ_CCDC62	CCDC62	atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0097669, generated from CCDC62, was up-regulated in epicardial adipose tissue from atrial fibrillation patients and verified among six candidate circRNAs by RT-qPCR. It was included in the predicted ceRNA network, but no circRNA-specific mechanistic assay was performed."	0.4032
36247236	American journal of translational research	2022	"The integrative network of circRNA, miRNA and mRNA of epicardial adipose tissue in patients with atrial fibrillation."	hsa_circ_0135289				atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0135289 was one of the most strongly down-regulated candidate circRNAs in epicardial adipose tissue from atrial fibrillation patients and was verified by RT-qPCR. Its potential role was inferred from the predicted circRNA-miRNA-mRNA network rather than from direct functional assays.	0.4032
36247236	American journal of translational research	2022	"The integrative network of circRNA, miRNA and mRNA of epicardial adipose tissue in patients with atrial fibrillation."	hsa_circ_0098155				atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0098155 was one of the most strongly down-regulated candidate circRNAs in epicardial adipose tissue from atrial fibrillation patients and was verified by RT-qPCR. Its potential involvement in atrial fibrillation was based on predicted ceRNA network analysis.	0.4032
36247236	American journal of translational research	2022	"The integrative network of circRNA, miRNA and mRNA of epicardial adipose tissue in patients with atrial fibrillation."	hsa_circ_0079672				atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0079672 was one of the most strongly down-regulated candidate circRNAs in epicardial adipose tissue from atrial fibrillation patients and was verified by RT-qPCR. The article predicted its possible relevance to atrial fibrillation using ceRNA network analysis.	0.4032
36247236	American journal of translational research	2022	"The integrative network of circRNA, miRNA and mRNA of epicardial adipose tissue in patients with atrial fibrillation."	hsa_circ_0078619				atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	dysregulated	RNA-seq	hsa_circ_0078619 was included in the limited predicted circRNA-miRNA-mRNA network derived from epicardial adipose tissue sequencing in atrial fibrillation. The authors proposed that it may act as an endogenous RNA sponge interacting with miRNAs such as miR-103a-2-5p and miR-199a-5p to regulate cardiovascular disorder-related mRNAs.	0.348
36250452	Human & experimental toxicology	2022	Has_circ_0010220 regulates the miR-574-3p/IL-6 axis to increase doxorubicin resistance in osteosarcoma.	hsa_circ_0010220		hsa_circ_ARHGEF10L	ARHGEF10L	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"hsa_circ_0010220 is up-regulated in DOX-resistant osteosarcoma tissues and cells. It promotes doxorubicin resistance by sponging miR-574-3p and thereby increasing IL-6 expression, making it a potential biomarker or therapeutic target for improving osteosarcoma chemotherapy."	0.7158
36250925	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2022	Disturbing NLRP3 acetylation and inflammasome assembly inhibits androgen receptor-promoted inflammatory responses and prostate cancer progression.	hsa_circ_0090925	circAR-3	hsa_circ_AR	AR	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; ISH	CircAR-3 (hsa_circ_0090925) is a human AR-derived circRNA upregulated in high-grade prostate cancer. It promotes PCa inflammatory responses and cell proliferation by enhancing KAT2B-mediated NLRP3 acetylation and stabilizing/assembling the NLRP3 inflammasome complex.	0.7907
36250950	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2022	circBGN accelerates gastric cancer cell proliferation and invasion via activating IL6/STAT3 signaling pathway.	hsa_circ_0091744	circBGN	hsa_circ_BGN	BGN	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; ISH	"circBGN is overexpressed in gastric cancer tissues and cell lines and acts as an oncogenic circRNA. It promotes GC cell proliferation, migration, invasion, and xenograft tumor growth by sponging miR-149-5p, increasing IL6 expression, and activating the IL6/STAT3 signaling pathway. Its elevated expression is associated with larger tumor size and more advanced tumor stage, suggesting potential therapeutic relevance."	0.84
36252429	Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association	2022	Circ_0101874 overexpression strengthens PDE4D expression by targeting miR-335-5p to promote neuronal injury in ischemic stroke.	hsa_circ_0101874	circ_0101874	hsa_circ_FKBP3	FKBP3	ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR	"Circ_0101874 is up-regulated in MCAO mouse models and OGD-induced SK-N-SH cells. It promotes ischemic stroke-related neuronal injury by sponging miR-335-5p and increasing PDE4D expression, thereby enhancing inflammation, apoptosis and oxidative stress while suppressing cell viability and proliferation."	0.7221
36252478	International immunopharmacology	2022	CircPalm2 knockdown alleviates LPS-evoked pulmonary microvascular endothelial cell apoptosis and inflammation via miR-450b-5p/ROCK1 axis.	mmu_circ_0001212	circPalm2	mmu_circ_Palm2	Palm2	sepsis-induced acute lung injury	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR	"In an LPS-induced MPVEC model of sepsis-ALI, circPalm2 is up-regulated and mainly localized in the cytoplasm. CircPalm2 promotes endothelial cell apoptosis and inflammatory cytokine production through a ceRNA mechanism in which it sponges miR-450b-5p to increase ROCK1 expression. Silencing circPalm2 protects against LPS-induced MPVEC injury and suggests a potential therapeutic strategy for sepsis-ALI."	0.7446
36255068	Anti-cancer drugs	2022	Circ_0026123 promotes cisplatin resistance and progression of ovarian cancer by upregulating RAB1A through sequestering miR-543.	hsa_circ_0026123	circ_0026123	hsa_circ_TUBA1B	TUBA1B	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circ_0026123 is up-regulated in cisplatin-resistant ovarian cancer tissues and cells. It promotes DDP resistance and malignant phenotypes including proliferation, angiogenesis, migration and invasion while suppressing apoptosis. Mechanistically, circ_0026123 functions as a cytoplasmic ceRNA that sponges miR-543 to increase RAB1A expression, and its knockdown sensitizes tumors to cisplatin in vitro and in vivo."	0.8175
36257575	The journal of pain	2023	Spinal CircKcnk9 Regulates Chronic Visceral Hypersensitivity of Irritable Bowel Syndrome.		circRNA_7685 / circKcnk9	rno_circ_Kcnk9	Kcnk9	irritable bowel syndrome / IBS	MONDO:0005052	irritable bowel syndrome	up-regulated	RT-qPCR; RNA-seq	"circKcnk9 is up-regulated in spinal neurons of IBS-like rats and promotes chronic visceral hypersensitivity and neuronal activation. Mechanistically, cytoplasmic circKcnk9 functions as a miR-124-3p sponge, relieving miR-124-3p-mediated repression of STAT3 and regulating the downstream STAT3/NSF/GluR2 pathway. Knockdown of circKcnk9 alleviates pain responses, suggesting circKcnk9 as a potential therapeutic target for IBS-related visceral hypersensitivity."	0.8166
36257578	The international journal of biochemistry & cell biology	2022	CircUBXN7 suppresses cell proliferation and facilitates cell apoptosis in lipopolysaccharide-induced cell injury by sponging miR-622 and regulating the IL6ST/JAK1/STAT3 axis.	hsa_circ_0001380	circUBXN7	hsa_circ_UBXN7	UBXN7	Acute respiratory distress syndrome / ARDS	MONDO:0006502	acute respiratory distress syndrome	up-regulated	RT-qPCR	"circUBXN7 is up-regulated in LPS-induced A549 and Beas-2B cell injury, an in vitro model relevant to ARDS. It suppresses cell proliferation and DNA synthesis while promoting apoptosis by sponging miR-622, increasing IL6ST expression, and activating the JAK1/STAT3 signaling pathway. The study proposes circUBXN7 as a potential ARDS biomarker and therapeutic target, although no patient cohort or in vivo validation was performed."	0.7822
36265392	Archives of oral biology	2022	Circular RNA_0076977 contributes to oral squamous cell carcinoma progression through mediating microRNA-802 axis.	hsa_circ_0076977	circ_0076977	hsa_circ_MTO1		oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"Circ_0076977 is up-regulated in OSCC tissues and cell lines and acts as an oncogenic circRNA. Its knockdown suppresses proliferation, angiogenesis, migration, invasion, EMT, and xenograft growth while inducing apoptosis. Mechanistically, circ_0076977 sponges miR-802 to positively regulate MYO6 expression, promoting OSCC progression through the circ_0076977/miR-802/MYO6 axis."	0.7375
36272155	Acta biochimica Polonica	2022	"Circ_FOXO3 regulates KLF6 through sponge adsorption of miR-122-5p to repress H2O2-induced HBVSMC proliferation, thus promoting IA development in vitro model."	hsa_circ_0006404	circ_FOXO3	hsa_circ_FOXO3	FOXO3	intracranial aneurysms / IA	MONDO:0005291	brain aneurysm	up-regulated	RT-qPCR	"This study found that circ_FOXO3 is up-regulated in IA tissues and in H2O2-treated HBVSMC. Functionally, circ_FOXO3 inhibits HBVSMC proliferation and promotes apoptosis, thereby aggravating H2O2-induced HBVSMC damage relevant to IA. Mechanistically, circ_FOXO3 sponges miR-122-5p and regulates its target KLF6, forming a circ_FOXO3/miR-122-5p/KLF6 axis with potential therapeutic significance."	0.7277
36278816	Histology and histopathology	2023	Circ_0008234 regulates the biological process of gallbladder carcinoma by targeting the miR-204-5p/FGFR2 axis.	hsa_circ_0008234	circ_0008234 / circ_FOXP1	hsa_circ_FOXP1	FOXP1	gallbladder cancer	MONDO:0003220	gallbladder carcinoma	up-regulated	RT-qPCR	"hsa_circ_0008234/circ_0008234 is up-regulated in gallbladder carcinoma tissues and cell lines and is associated with TNM stage, lymph node metastasis and tumor size. Functionally, circ_0008234 promotes malignant GBC phenotypes including proliferation, migration, invasion and xenograft tumor growth while suppressing apoptosis. Mechanistically, it mainly acts through a ceRNA axis by targeting miR-204-5p and regulating FGFR2 expression."	0.7861
36279855	"Digestive diseases (Basel, Switzerland)"	2023	Application of Circular RNA Circ_0071662 in the Diagnosis and Prognosis of Hepatocellular Carcinoma and Its Response to Radiotherapy.		Circ_0071662			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"Circ_0071662 is downregulated in HCC plasma and tumor tissues. Its decreased expression can distinguish HCC from healthy controls and other clinically similar diseases, is associated with poor survival and adverse clinical features, and may indicate radioresistance after SBRT."	0.4992
36286392	Histology and histopathology	2023	Hsa_circ_0093741 competes with FRS2 for miR-562 binding sites to promote nephroblastoma progression.	hsa_circ_0093741		hsa_circ_PCDH15	PCDH15	nephroblastoma	MONDO:0019004	kidney Wilms tumor	up-regulated	RT-qPCR	"hsa_circ_0093741 is up-regulated in nephroblastoma tissues and cell lines and is associated with larger tumor size and advanced NWTS-5 stage. It promotes nephroblastoma proliferation, invasion, migration and xenograft tumor growth by acting as a cytoplasmic miR-562 sponge to increase FRS2 expression."	0.8175
36289041	Clinical breast cancer	2023	Circ_0001667 Promotes Adriamycin Resistance and Malignant Progression via Targeting the miR-193a-5p/Rap2A Molecular Axis in Breast Cancer.	hsa_circ_0001667	circ_0001667	hsa_circ_HEATR2	HEATR2	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0001667 is up-regulated in breast cancer, especially in ADM-resistant tissues and cells. It promotes ADM resistance and malignant progression by sponging miR-193a-5p to increase Rap2A expression, thereby enhancing proliferation, migration and invasion while reducing apoptosis. Knockdown of circ_0001667 suppresses tumor growth in a cell line-derived xenograft model and may improve ADM sensitivity."	0.8175
36300495	Histology and histopathology	2023	Circ_0085616 contributes to the radio-resistance and progression of cervical cancer by targeting miR-541-3p/ARL2 signaling.	hsa_circ_0085616	circ_0085616	hsa_circ_ASAP1	ASAP1	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ_0085616 is up-regulated in cervical cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes radio-resistance, proliferation, angiogenesis, migration, invasion and tumor growth while suppressing apoptosis, mainly by sponging miR-541-3p to increase ARL2 signaling."	0.7375
36301978	Drug development research	2022	Circ_0002099 is a novel molecular therapeutic target for bladder cancer.	hsa_circ_0002099	Circ_0002099	hsa_circ_SEMA5A	SEMA5A	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"Circ_0002099 is a SEMA5A-derived circRNA that is upregulated in bladder cancer tissues and cell lines, and high expression is associated with poorer prognosis and tumor grade. Functionally, Circ_0002099 promotes BLCA proliferation, migration, invasion, tumorigenesis, and EMT. Mechanistically, FUS promotes Circ_0002099 biogenesis, while cytoplasmic Circ_0002099 sponges miR-217-5p and miR-103a-3p to increase KRAS and activate the WNT/beta-catenin-related EMT program."	0.8768
36306116	Advances in clinical and experimental medicine : official organ Wroclaw Medical University	2023	CircHIPK3 promotes neuroinflammation through regulation of the miR-124-3p/STAT3/NLRP3 signaling pathway in Parkinson's disease.	hsa_circ_0000284	circHIPK3 / circRNA homeodomain interacting protein kinase 3	hsa_circ_HIPK3		Parkinson's disease / PD	MONDO:0005180	Parkinson disease	up-regulated	RT-qPCR	"circHIPK3 is up-regulated in serum/blood and CSF from PD patients and in LPS-induced PD-related cell models. It promotes neuroinflammation, microglial activation, pyroptosis, inflammatory cytokine release, and ROS production by sponging miR-124 and activating the STAT3/NLRP3 signaling pathway, suggesting potential therapeutic relevance in PD."	0.7618
36315192	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2022	CircRNA_45478 promotes ischemic AKI by targeting the miR-190a-5p/PHLPP1 axis.		circRNA_45478			acute kidney injury / AKI	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR; ISH; Microarray	"circRNA_45478 is induced in mouse ischemic AKI models and I/R-treated BUMPT cells. It promotes renal cell apoptosis and ischemic kidney injury by sponging miR-190a-5p and increasing PHLPP1 expression, while circRNA_45478 knockdown alleviates AKI progression."	0.6174
36319130	Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery	2022	[hsa_circ_0000231 affects the progression of tongue squamous cell carcinoma by activating Wnt/beta-catenin signaling pathway].	hsa_circ_0000231				tongue squamous cell carcinoma / TSCC	MONDO:0000500	tongue squamous cell carcinoma	up-regulated	RT-qPCR	"hsa_circ_0000231 is up-regulated in TSCC tissues, saliva samples, and TSCC cell lines. Its high expression is associated with poor prognosis, and functional experiments indicate that it promotes TSCC proliferation, invasion, migration/metastasis and EMT by activating the Wnt/beta-catenin signaling pathway."	0.648
36329577	Nan fang yi ke da xue xue bao = Journal of Southern Medical University	2022	"[CircPCSK5 is highly expressed in gastric cancer and promotes cancer cell proliferation, invasion and epithelial-mesenchymal transition]."	hsa_circ_0087234	circPCSK5	hsa_circ_PCSK5	PCSK5	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"circPCSK5 (hsa_circ_0087234), derived from PCSK5, is up-regulated in gastric cancer tissues and cell lines. Its high expression predicts poorer overall and disease-free survival, while functional assays show that circPCSK5 promotes gastric cancer cell proliferation, migration, invasion and EMT."	0.8218
36331285	Histology and histopathology	2023	"Circ_0000284 facilitates the growth, metastasis and glycolysis of intrahepatic cholangiocarcinoma through miR-152-3p-mediated PDK1 expression."	hsa_circ_0000284	circ_0000284 / circHIPK3	hsa_circ_HIPK3	HIPK3	intrahepatic cholangiocarcinoma / ICC	MONDO:0003210	intrahepatic cholangiocarcinoma	up-regulated	RT-qPCR	"circ_0000284 is up-regulated in ICC tissues and cells and is associated with lymph node metastasis and poorer overall survival. Functionally, it promotes ICC proliferation, invasion, migration, glycolysis and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ_0000284 acts as a cytoplasmic ceRNA sponge for miR-152-3p, thereby increasing PDK1 expression and driving ICC malignant progression."	0.8157
36343886	Transplant immunology	2022	CircSCNN1A is a tumor suppressor in renal cell carcinoma via inducing the upregulation of MPP7 by the sponge effect on miR-421.	hsa_circ_0025135	circSCNN1A / CircRNA Sodium Channel Epithelial 1 Subunit Alpha	hsa_circ_SCNN1A	SCNN1A	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	down-regulated	RT-qPCR	"circSCNN1A is down-regulated in RCC tissues and cell lines and is associated with diagnostic and prognostic value. Functionally, circSCNN1A suppresses RCC cell proliferation, invasion, angiogenesis, and xenograft tumor growth while promoting apoptosis. Mechanistically, it acts as a miR-421 sponge to up-regulate the tumor-suppressive target MPP7."	0.8583
36356335	"Pathology, research and practice"	2022	Circular RNA ciRS-7 promotes laryngeal squamous cell carcinoma development by inducing TGM3 hypermethylation via miR-432-5p/DNMT3B axis.		circular RNA ciRS-7 / ciRS-7	hsa_circ_CDR1as		laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR	"ciRS-7 is up-regulated in LSCC tissues and cell lines and is associated with advanced clinical stage, infiltration, and lymph node metastasis. Functionally, ciRS-7 promotes LSCC cell viability, migration, invasion, EMT, and xenograft tumor growth while inhibiting apoptosis. Mechanistically, ciRS-7 sponges miR-432-5p to increase DNMT3B expression, leading to TGM3 hypermethylation and suppression."	0.8275
36356557	Reproductive biology	2022	Hsa_circ_0069094 positively regulates the expression of oncogenic ZNF217 by competitively targeting miR-758-3p to promote the development of breast cancer.	hsa_circ_0069094	circ_0069094	hsa_circ_S100P		breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"Hsa_circ_0069094 is up-regulated in breast cancer tissues and cells and functions as an oncogenic circRNA. It promotes proliferation, invasion, migration, cell cycle progression and tumor growth while inhibiting apoptosis, mainly through a ceRNA mechanism involving miR-758-3p and ZNF217."	0.8006
36370665	Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy	2022	N6-methyladenosine-modified circular RNA QSOX1 promotes colorectal cancer resistance to anti-CTLA-4 therapy through induction of intratumoral regulatory T cells.	hsa_circ_0015497	circQSOX1	hsa_circ_QSOX1	QSOX1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circQSOX1 is upregulated in CRC tissues and cells and high expression is associated with poor overall and disease-free survival. METTL3-mediated m6A modification stabilizes circQSOX1 through IGF2BP2, while circQSOX1 promotes CRC progression via the miR-326/miR-330-5p/PGAM1 ceRNA axis. This axis enhances glycolysis and lactic acid accumulation, promoting Treg-mediated immune escape and resistance to anti-CTLA-4 therapy."	0.8892
36374958	"Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer"	2022	CircCHD2/miR-200b-3p/HLF Axis Promotes Liver Cirrhosis.	hsa_circ_0037006	circCHD2	hsa_circ_CHD2	CHD2	liver fibrosis	MONDO:0005155	cirrhosis of liver	up-regulated	RT-qPCR	"In this study, circCHD2 was up-regulated in serum from patients with liver cirrhosis and in TGF-beta1-activated LX-2 hepatic stellate cells. Functionally, circCHD2 promoted activated HSC proliferation and fibrosis-marker expression, while circCHD2 knockdown alleviated these effects through the miR-200b-3p/HLF ceRNA axis. The authors propose circCHD2 as a potential therapeutic target for liver cirrhosis."	0.6521
36382967	Histology and histopathology	2023	Circ_0079530 stimulates THBS2 to promote the malignant progression of non-small cell lung cancer by sponging miR-584-5p.	hsa_circ_0079530	Circ_0079530	hsa_circ_TWIST1	TWIST1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0079530 is up-regulated in NSCLC tissues and cell lines and acts as an oncogenic circRNA. It promotes proliferation, migration, invasion, metastasis and xenograft tumor growth while suppressing apoptosis, mainly by sponging miR-584-5p to increase THBS2 expression. The study suggests circ_0079530 as a potential circRNA-targeted therapeutic candidate for NSCLC."	0.8299
36394255	Histology and histopathology	2023	Circular RNA hsa_circ_0003892 promotes the development of papillary thyroid carcinoma by regulating the miR-326/LASP1 axis.	hsa_circ_0003892	circRNA_0003892			papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR; Microarray	"Hsa_circ_0003892 is up-regulated in PTC tissues and cell lines and is associated with larger tumor size and extrathyroidal invasion. It promotes PTC cell proliferation, migration and invasion by sponging miR-326 and increasing LASP1 mRNA/protein expression, suggesting potential biomarker and therapeutic target value."	0.7283
36394342	Carcinogenesis	2023	Hsa_circ_0094606 promotes malignant progression of prostate cancer by inducing M2 polarization of macrophages through PRMT1-mediated arginine methylation of ILF3.	hsa_circ_0094606	circ_0094606	hsa_circ_SORBS1	SORBS1	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0094606/circ_0094606 is up-regulated in prostate cancer tissues and cells. It promotes PCa proliferation, migration, EMT, xenograft growth, and macrophage M2 polarization by binding PRMT1, enhancing PRMT1-mediated ILF3 arginine methylation, and increasing IL-8 mRNA stability/expression. The study proposes circ_0094606 as a potential therapeutic target for PCa."	0.8856
36394459	DNA and cell biology	2022	Circular RNA circFoxo3 Promotes Granulosa Cell Apoptosis Under Oxidative Stress Through Regulation of FOXO3 Protein.	hsa_circ_0006404 	circFoxo3	hsa_circ_FOXO3	FOXO3	ovarian oxidative stress	MONDO:0001889	ovarian dysfunction	up-regulated	RT-qPCR	"circFoxo3 is up-regulated in H2O2-treated granulosa cells and in a 3-NP-induced ovarian oxidative stress mouse model. It promotes granulosa cell apoptosis by interacting with MDM2 and regulating FOXO3 protein levels, thereby affecting MDM2-mediated FOXO3 ubiquitination and degradation. The study proposes circFoxo3 as a potential therapeutic target for reducing granulosa cell apoptosis in ovarian disorders."	0.7888
36394459	DNA and cell biology	2022	Circular RNA circFoxo3 Promotes Granulosa Cell Apoptosis Under Oxidative Stress Through Regulation of FOXO3 Protein.	mmu_circ_0002207	circFoxo3	mmu_circ_Foxo3	FOXO3	ovarian oxidative stress	MONDO:0001889	ovarian dysfunction	up-regulated	RT-qPCR	"circFoxo3 is up-regulated in H2O2-treated granulosa cells and in a 3-NP-induced ovarian oxidative stress mouse model. It promotes granulosa cell apoptosis by interacting with MDM2 and regulating FOXO3 protein levels, thereby affecting MDM2-mediated FOXO3 ubiquitination and degradation. The study proposes circFoxo3 as a potential therapeutic target for reducing granulosa cell apoptosis in ovarian disorders."	0.7888
36396726	Oncogene	2023	Hypoxia-induced circADAMTS6 in a TDP43-dependent manner accelerates glioblastoma progression via ANXA2/ NF-kappaB pathway.	hsa_circ_0072688	circADAMTS6	hsa_circ_ADAMTS6	ADAMTS6	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; RNA-seq	"circADAMTS6 is a hypoxia-induced, upregulated circRNA in glioblastoma that promotes tumor growth by enhancing proliferation, cell cycle progression and stem-like self-renewal while suppressing apoptosis. Its biogenesis is driven by AP-1/JUN transcriptional activation and TDP43/HNRNPA1-mediated cyclization, and it functions mainly by binding ANXA2, preventing ANXA2 ubiquitination, stabilizing ANXA2 protein and activating NF-kappaB signaling. High circADAMTS6 expression is associated with poor prognosis and diagnostic value, and pharmacologic AP-1 inhibition by T-5224 downregulates circADAMTS6 and suppresses GBM growth."	0.8996
36399118	Avian pathology : journal of the W.V.P.A	2023	Genome-wide characterization of circRNA expression profile in overexpression of RIP2 chicken macrophages associated with avian pathogenic E.coli infection.		5:814443-825127 / 15:814443-825127 / circMAPK3	gga_circ_MAPK3	MAPK3	avian pathogenic E. coli infection / APEC infection	MONDO:0020920	escherichia coli infection	up-regulated	RNA-seq	"circMAPK3 is a chicken circRNA identified as a key up-regulated candidate in RIP2-overexpressing macrophages during APEC infection. The study predicts that it may function through miRNA-sponge/ceRNA-related mechanisms and pathway programs including MAPK and Wnt-related signaling, but functional validation was not performed."	0.2414
36399118	Avian pathology : journal of the W.V.P.A	2023	Genome-wide characterization of circRNA expression profile in overexpression of RIP2 chicken macrophages associated with avian pathogenic E.coli infection.		10:18922360-18928461 / circMAP2K1	gga_circ_MAP2K1	MAP2K1	avian pathogenic E. coli infection / APEC infection	MONDO:0020920	escherichia coli infection	up-regulated	RT-qPCR; RNA-seq	circMAP2K1 is an up-regulated chicken circRNA candidate in RIP2-overexpressing macrophages under APEC infection. It was validated by RT-qPCR and is predicted to act as a miRNA sponge/ceRNA related to MAPK and other immune-inflammatory signaling pathways.	0.329
36399118	Avian pathology : journal of the W.V.P.A	2023	Genome-wide characterization of circRNA expression profile in overexpression of RIP2 chicken macrophages associated with avian pathogenic E.coli infection.		2:8746306-8750639 / 2:8746306-8760557 / circDNAJB6	gga_circ_DNAJB6	DNAJB6	avian pathogenic E. coli infection / APEC infection	MONDO:0020920	escherichia coli infection	up-regulated	RT-qPCR; RNA-seq	"circDNAJB6 is an up-regulated chicken circRNA validated by RT-qPCR in RIP2-overexpressing macrophages with or without APEC infection. The study predicts that circDNAJB6 may regulate host immune response through interaction with gga-miR-1306-5p, but direct mechanistic functional validation remains lacking."	0.329
36399118	Avian pathology : journal of the W.V.P.A	2023	Genome-wide characterization of circRNA expression profile in overexpression of RIP2 chicken macrophages associated with avian pathogenic E.coli infection.		2:124177751-124184063 / circRIP2	gga_circ_RIP2	RIP2	avian pathogenic E. coli infection / APEC infection	MONDO:0020920	escherichia coli infection	dysregulated	RT-qPCR; RNA-seq	"circRIP2 is a chicken circRNA candidate identified in RIP2-overexpressing macrophages associated with APEC infection. It was included among key circRNAs with predicted miRNA-binding sites and was RT-qPCR validated for expression trend, but the study did not provide detailed functional validation or named miRNA partners for this circRNA."	0.329
36403901	Toxicology	2023	Identification of circRNA expression profiles and the potential role of hsa_circ_0006916 in silicosis and pulmonary fibrosis.	hsa_circ_0006916	novel_circ_000359	hsa_circ_HOMER1	HOMER1	silicosis	MONDO:0005960	silicosis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0006916, also described as novel_circ_000359, was up-regulated in silica-induced pulmonary fibrosis models and silica-stimulated alveolar macrophages. Functional knockdown experiments suggest that it participates in macrophage polarization regulation rather than a predicted ceRNA network in this study."	0.6528
36403901	Toxicology	2023	Identification of circRNA expression profiles and the potential role of hsa_circ_0006916 in silicosis and pulmonary fibrosis.		novel_-circ_003722			silicosis	MONDO:0005960	silicosis	up-regulated	RT-qPCR; RNA-seq	"novel_-circ_003722 was experimentally validated by RT-qPCR as an up-regulated circRNA in silica-induced fibrotic mouse lung tissues. The study suggests it may be related to pulmonary fibrosis pathogenesis, but no specific mechanistic axis was reported for this circRNA."	0.642
36403901	Toxicology	2023	Identification of circRNA expression profiles and the potential role of hsa_circ_0006916 in silicosis and pulmonary fibrosis.		novel_circ_004391			silicosis	MONDO:0005960	silicosis	up-regulated	RT-qPCR; RNA-seq	novel_circ_004391 was validated by RT-qPCR as an up-regulated circRNA in fibrotic lung tissues from silica-exposed mice. The paper links its abnormal expression to pulmonary fibrosis pathogenesis but does not provide a specific mechanism for this circRNA.	0.642
36403901	Toxicology	2023	Identification of circRNA expression profiles and the potential role of hsa_circ_0006916 in silicosis and pulmonary fibrosis.		novel_circ_001674			silicosis	MONDO:0005960	silicosis	down-regulated	RT-qPCR; RNA-seq	novel_circ_001674 was validated by RT-qPCR as a down-regulated circRNA in silica-induced fibrotic mouse lung tissues. Its specific molecular mechanism was not investigated further in the text.	0.642
36403901	Toxicology	2023	Identification of circRNA expression profiles and the potential role of hsa_circ_0006916 in silicosis and pulmonary fibrosis.		novel_circ_004728			silicosis	MONDO:0005960	silicosis	down-regulated	RT-qPCR; RNA-seq	"novel_circ_004728 was validated by RT-qPCR as a down-regulated circRNA in silica-induced fibrotic mouse lung tissues. The article suggests its abnormal expression may be involved in pulmonary fibrosis pathogenesis, but no specific downstream mechanism was reported."	0.642
36403901	Toxicology	2023	Identification of circRNA expression profiles and the potential role of hsa_circ_0006916 in silicosis and pulmonary fibrosis.		novel_circ_002329			silicosis	MONDO:0005960	silicosis	dysregulated	RNA-seq	novel_circ_002329 was identified from the study's dysregulated circRNA ceRNA network as a potential ceRNA of mmu-miR-199b-5p targeting Irf4. This association was based on RNA-seq and bioinformatics network analysis rather than RT-qPCR validation for this specific circRNA.	0.6089
36403901	Toxicology	2023	Identification of circRNA expression profiles and the potential role of hsa_circ_0006916 in silicosis and pulmonary fibrosis.		novel_circ_003033			silicosis	MONDO:0005960	silicosis	dysregulated	RNA-seq	novel_circ_003033 was identified as a potential ceRNA of mmu-miR-199b-5p targeting Irf4 in the pulmonary fibrosis ceRNA network. Evidence for this circRNA is based on RNA-seq-derived differential expression and computational network analysis.	0.6089
36403901	Toxicology	2023	Identification of circRNA expression profiles and the potential role of hsa_circ_0006916 in silicosis and pulmonary fibrosis.		novel_circ_002676			silicosis	MONDO:0005960	silicosis	dysregulated	RNA-seq	"novel_circ_002676 was proposed as a ceRNA of mmu-miR-296-5p targeting Sfrp1 in the silica-induced pulmonary fibrosis network. Its evidence is computational and RNA-seq based, without specific RT-qPCR validation reported for this circRNA."	0.6089
36403901	Toxicology	2023	Identification of circRNA expression profiles and the potential role of hsa_circ_0006916 in silicosis and pulmonary fibrosis.		novel_circ_002012			silicosis	MONDO:0005960	silicosis	dysregulated	RNA-seq	"novel_circ_002012 was proposed as a mmu-miR-708-5p-related ceRNA in the pulmonary fibrosis regulatory network. Xcr1 was described as a target contained in all three related ceRNA triples, but this mechanism was computationally inferred rather than experimentally validated for this circRNA."	0.6089
36403901	Toxicology	2023	Identification of circRNA expression profiles and the potential role of hsa_circ_0006916 in silicosis and pulmonary fibrosis.		novel_circ_002219			silicosis	MONDO:0005960	silicosis	dysregulated	RNA-seq	"novel_circ_002219 was proposed as a mmu-miR-708-5p-related ceRNA in the pulmonary fibrosis network. Xcr1 was named as a target included in the three related ceRNA triples, but the association was bioinformatically inferred."	0.6089
36403901	Toxicology	2023	Identification of circRNA expression profiles and the potential role of hsa_circ_0006916 in silicosis and pulmonary fibrosis.		novel_circ_002951			silicosis	MONDO:0005960	silicosis	dysregulated	RNA-seq	"novel_circ_002951 was proposed as a mmu-miR-708-5p-related ceRNA in the silica-induced pulmonary fibrosis regulatory network. Xcr1 was included in the related ceRNA triples, but no circRNA-specific experimental validation was reported."	0.6089
36409993	Journal of neuropathology and experimental neurology	2022	Inhibition of circ_0004381 improves cognitive function via miR-647/PSEN1 axis in an Alzheimer disease mouse model.	mmu_circ_0004381	circ_0004381			Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR	"circ_0004381 is up-regulated in Abeta1-42-treated hippocampal neurons and AD model mouse brain tissue. Its inhibition protects hippocampal neurons from apoptosis, oxidative stress and mitochondrial dysfunction, shifts microglia toward an M2 anti-inflammatory phenotype, and improves cognitive impairment. Mechanistically, circ_0004381 regulates PSEN1 expression by sponging miR-647."	0.6441
36413177	Advances in clinical and experimental medicine : official organ Wroclaw Medical University	2023	hsa_circ_0038382 upregulates T-box transcription factor 5 to inhibit keloid formation by interacting with miR-940.	hsa_circ_0038382	ASCRP3013082			keloid	MONDO:0005348	keloid	down-regulated	RT-qPCR; Microarray	"hsa_circ_0038382 is downregulated in keloid tissues and human keloid fibroblasts. Functionally, it suppresses keloid fibroblast proliferation, migration and invasion, thereby attenuating keloid formation. Mechanistically, it binds miR-940 and upregulates TBX5 as part of a hsa_circ_0038382/miR-940/TBX5 ceRNA regulatory axis."	0.6815
36416408	Histology and histopathology	2023	CircRNA hsa_circ_0075048 promotes the malignant progression of non-small cell lung cancer by up-regulating HMGB2 expression via targeting miR-1225-5p.	hsa_circ_0075048	circ_0075048	hsa_circ_ERGIC1	ERGIC1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0075048 is up-regulated in NSCLC tissues and cell lines and is associated with poor overall survival, advanced TNM stage and tumor size. Functionally, it promotes malignant phenotypes including proliferation, migration, invasion, sphere formation and in vivo tumor growth while suppressing apoptosis. Mechanistically, cytoplasmic circ_0075048 sponges miR-1225-5p to increase HMGB2 expression."	0.8823
36417821	International immunopharmacology	2022	CircWDR33 alleviates human pulmonary microvascular endothelial cell injury in sepsis-associated acute lung injury by targeting miR-217-5p/SERP1 axis.	hsa_circ_0003192	circWDR33	hsa_circ_WDR33	WDR33	sepsis-induced acute lung injury	MONDO:0015796	acute lung injury	down-regulated	RT-qPCR	"circWDR33 is down-regulated in sera from sepsis-ALI patients and in LPS-challenged HPMECs. Its overexpression protects HPMECs from LPS-induced inflammation, apoptosis, permeability increase, and tubule formation impairment through the miR-217-5p/SERP1 ceRNA axis, suggesting therapeutic potential in sepsis-ALI."	0.7795
36417875	Cell reports	2022	circPRKAA1 activates a Ku80/Ku70/SREBP-1 axis driving de novo fatty acid synthesis in cancer cells.		circPRKAA1 / hsa_circ_000955	hsa_circ_PRKAA1	PRKAA1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Northern Blot; ISH	"circPRKAA1 is an upregulated PRKAA1-derived circRNA in hepatocellular carcinoma. It promotes HCC cell lipogenesis and tumor growth by binding Ku80/Ku70, stabilizing mSREBP-1, and recruiting mSREBP-1 to fatty-acid-synthesis gene promoters including ACC1, ACLY, SCD1, and FASN. Low AMPK activity promotes circPRKAA1 biogenesis through SRSF1-dependent splicing, and high circPRKAA1 expression is negatively correlated with p-AMPK in HCC tissues."	0.8882
36418471	Oncogene	2023	Novel hypoxia-induced HIF1alpha-circTDRD3-positive feedback loop promotes the growth and metastasis of colorectal cancer.	hsa_circ_0003441	circTDRD3	hsa_circ_TDRD3	TDRD3	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; RNA-seq	"circTDRD3 is a hypoxia-induced, cytoplasmic circRNA upregulated in CRC tissues and cell lines. It promotes CRC proliferation, invasion and metastasis by sponging miR-1231 to increase HIF1alpha, while HIF1alpha and PTBP1 further enhance circTDRD3 biogenesis, forming a tumor-promoting positive feedback loop. High circTDRD3 expression is associated with unfavorable clinicopathological features and poor survival."	0.8981
36418471	Oncogene	2023	Novel hypoxia-induced HIF1alpha-circTDRD3-positive feedback loop promotes the growth and metastasis of colorectal cancer.	hsa_circ_0001824				colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0001824 was identified among hypoxia-associated circRNAs and was experimentally validated by qRT-PCR as significantly increased in CRC tissues. The article did not further investigate its biological function or mechanism.	0.4032
36418471	Oncogene	2023	Novel hypoxia-induced HIF1alpha-circTDRD3-positive feedback loop promotes the growth and metastasis of colorectal cancer.	hsa_circ_0000284				colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0000284 was identified among hypoxia-associated circRNAs and was experimentally validated by qRT-PCR as significantly increased in CRC tissues. The article did not further investigate its biological function or mechanism.	0.4032
36426627	Journal of biochemical and molecular toxicology	2023	Hsa_circ_0000129 drives tumor growth via sequestering miR-485-3p and upregulating SPIN1 in breast cancer.	hsa_circ_0000129	circ_0000129	hsa_circ_TMOD4	TMOD4	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000129/circ_0000129 is up-regulated in breast cancer tissues and cell lines. It promotes malignant breast cancer phenotypes, including proliferation, migration, invasion, angiopoiesis, and xenograft tumor growth, while suppressing apoptosis. Mechanistically, it localizes mainly in the cytoplasm and acts as a miR-485-3p sponge to relieve miR-485-3p-mediated repression of SPIN1."	0.8512
36426731	Histology and histopathology	2023	Circ_0007385 promotes the proliferation and inhibits the apoptosis of non-small cell lung cancer cells via miR-337-3p-dependent regulation of LMO3.	hsa_circ_0007385	circular RNA_0007385 / circ_0007385	hsa_circ_MEMO1	MEMO1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0007385 is up-regulated in NSCLC tissues and cell lines and acts as an oncogenic circRNA. It promotes proliferation and cell cycle progression, inhibits apoptosis, and supports xenograft tumor growth by sponging miR-337-3p to increase LMO3 expression. High circ_0007385 expression is associated with adverse clinicopathological features in NSCLC patients."	0.8175
36435226	Life sciences	2023	Myc-mediated circular RNA circMcph1/miR-370-3p/Irak2 axis is a progressive regulator in hepatic fibrosis.	mmu_circ_0001663	circMcph1	mmu_circ_Mcph1	Mcph1	hepatic fibrosis	MONDO:0005155	cirrhosis of liver	up-regulated	RT-qPCR; ISH	"circMcph1 is a mouse Mcph1-derived circRNA that is up-regulated in CCl4-induced hepatic fibrosis and inflammatory RAW264.7 cell models. Myc promotes circMcph1 biogenesis, and circMcph1 promotes inflammatory and fibrotic injury by sponging miR-370-3p to regulate Irak2. Silencing circMcph1 reduces pro-inflammatory factors, apoptosis, liver damage, and fibrosis, suggesting therapeutic potential in hepatic fibrosis."	0.8412
36435914	Journal of molecular histology	2023	Circ_0136474 promotes the progression of osteoarthritis by sponging mir-140-3p and upregulating MECP2.	hsa_circ_0136474	circ_0136474	hsa_circ_ASH2L	ASH2L	osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"Circ_0136474 is up-regulated in osteoarthritis cartilage tissues and IL-1beta-treated CHON-001 cells. It promotes OA progression by sponging miR-140-3p and upregulating MECP2, thereby enhancing chondrocyte apoptosis, ECM degradation, and inflammation while suppressing cell proliferation."	0.7785
36436315	"Pathology, research and practice"	2023	Circ_0008784 activates Wnt/beta-catenin pathway to affect the proliferation and apoptosis of triple-negative breast cancer cells.	hsa_circ_0008784	circ_0008784	hsa_circ_TNFRSF19	TNFRSF19	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0008784 is overexpressed in TNBC tissues and cells and promotes TNBC cell proliferation while inhibiting apoptosis. Mechanistically, it functions as a ceRNA by sponging miR-506-3p to regulate CTNNB1/beta-catenin and activate the Wnt/beta-catenin pathway, suggesting potential value as a therapeutic target for TNBC."	0.8006
36436682	Cancer letters	2023	CircPTK2/PABPC1/SETDB1 axis promotes EMT-mediated tumor metastasis and gemcitabine resistance in bladder cancer.	hsa_circ_0005982	circPTK2	hsa_circ_PTK2	PTK2	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; RNA-seq	"circPTK2 is an upregulated human circRNA derived from PTK2 in bladder cancer tissues and gemcitabine-resistant BCa cells. It promotes EMT-mediated migration, invasion, lymph node metastasis, and gemcitabine resistance by binding PABPC1 and enhancing PABPC1-dependent stabilization of SETDB1 mRNA, thereby increasing SETDB1 expression."	0.8924
36436795	Transplant immunology	2023	Circular RNA circ_0114876 regulates osteoarthritis through upregulating ADAM10 via targeting miR-1227-3p.	hsa_circ_0114876	circ_0114876	hsa_circ_PTPRA	PTPRA	Osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circ_0114876 is up-regulated in OA tissues and LPS-induced human chondrocytes. Functionally, circ_0114876 promotes OA-like chondrocyte injury by inhibiting proliferation and enhancing apoptosis, inflammation, and ECM degradation. Mechanistically, circ_0114876 functions through the miR-1227-3p/ADAM10 ceRNA axis and may represent a potential therapeutic or diagnostic target for OA."	0.7945
36441649	Clinical and experimental rheumatology	2023	Circular RNA expression profiles and identification of hsa_circ_0028381 as a potential biomarker of anti-neutrophil cytoplasmic antibody-associated vasculitis.	hsa_circ_0028381	circRNA_1331	hsa_circ_HECTD4	HECTD4	anti-neutrophil cytoplasmic antibody-associated vasculitis	MONDO:0015492	anti-neutrophil cytoplasmic antibody-associated vasculitis	up-regulated	RT-qPCR; RNA-seq	"This study identified plasma hsa_circ_0028381 as significantly up-regulated in AAV and validated it by qRT-PCR in clinical samples. hsa_circ_0028381 showed diagnostic value for distinguishing AAV from controls and was associated with renal involvement. Higher baseline hsa_circ_0028381 levels predicted progression to ESRD, suggesting potential value as a renal prognostic biomarker."	0.5534
36442661	Molecular and cellular probes	2023	Circular RNA ITCH increases sorafenib-sensitivity in hepatocellular carcinoma via sequestering miR-20b-5p and modulating the downstream PTEN-PI3K/Akt pathway.		circITCH / Circular RNA itchy E3 ubiquitin-protein ligase	hsa_circ_ITCH	ITCH	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"circITCH is down-regulated in HCC tissues and cell lines, especially in sorafenib-resistant HCC cells, and low circITCH expression is associated with poorer prognosis. Functionally, circITCH overexpression enhances sorafenib sensitivity, promotes apoptosis, and suppresses migration in sorafenib-resistant HCC cells by sponging miR-20b-5p, increasing PTEN, and inhibiting PI3K/Akt signaling."	0.7779
36444162	The Journal of pharmacy and pharmacology	2023	Circ_0000253 promotes the progression of osteosarcoma via the miR-1236-3p/SP1 axis.	hsa_circ_0000253	circ_0000253			osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"circ_0000253 is upregulated in human osteosarcoma tissues and cell lines. Functionally, it promotes OS cell growth and proliferation while inhibiting apoptosis. Mechanistically, circ_0000253 directly targets miR-1236-3p and positively regulates SP1 expression through the miR-1236-3p/SP1 axis."	0.7283
36448377	Environmental toxicology	2023	Hsa_circ_0001944 regulates apoptosis by regulating the binding of PARP1 and HuR in leukemia and malignant transformed cells induced by hydroquinone.	hsa_circ_0001944				leukemia	MONDO:0005059	leukemia	up-regulated	RT-qPCR	"This study found that hsa_circ_0001944 is upregulated in leukemia patient PBMCs and HQ-induced malignant transformed TK6 cells. Functional knockdown experiments indicate that hsa_circ_0001944 supports cell growth and cell cycle progression while suppressing apoptosis. Mechanistically, it may target HuR and disrupt HuR-PARP1 binding, thereby regulating PARP1 expression and the PARP1/H-Ras pathway."	0.73
36450208	International immunopharmacology	2023	The aggravate role of exosomal circRNA11:120406118|12040782 on macrophage pyroptosis through miR-30b-5p/NLRP3 axis in silica-induced lung fibrosis.		circRNA11:120406118|12040782			silicosis	MONDO:0005960	silicosis	up-regulated	RT-qPCR; RNA-seq	"This study identified exosomal circRNA11:120406118|12040782 as up-regulated in peripheral serum exosomes from silicosis patients and in silica-treated THP-1 macrophages. Mechanistically, it functions as a ceRNA that sponges miR-30b-5p, thereby enhancing NLRP3-mediated inflammasome activation, macrophage pyroptosis, and fibroblast activation, contributing to silicosis-related inflammation and fibrosis."	0.8386
36454423	"Medical oncology (Northwood, London, England)"	2022	Gastric cancer stem cell-derived exosomes promoted tobacco smoke-triggered development of gastric cancer by inducing the expression of circ670.		hsa-circRNA-000670 / circ670			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"This study identified circ670 as an up-regulated exosomal circRNA in gastric cancer tissues from patients with smoking history, tobacco smoke-induced GCSCs, and GCSC-derived exosomes. Exosomal circ670 promotes tobacco smoke-triggered gastric cancer development by enhancing GCSC stemness and EMT, and its knockdown suppresses these effects while overexpression enhances them. The authors propose exosomal circ670 as a potential prevention and treatment target for gastric cancer."	0.6676
36454505	Metabolic brain disease	2023	CircRNA circ_POSTN promotes the malignancy of glioma by regulating the miR-433-3p/SPARC axis.	hsa_circ_0030018	hsa_circPOSTN_001 / circ_POSTN	hsa_circ_POSTN	POSTN	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ_POSTN is up-regulated in glioma tissues and cells and functions as an oncogenic circRNA. It promotes glioma cell clonogenicity, migration, metastasis and xenograft tumor growth while suppressing apoptosis, at least partly by sponging miR-433-3p to increase SPARC expression. Its high expression is associated with TNM stage and tumor size, supporting its potential as a therapeutic target."	0.7591
36454517	Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico	2023	C-Fos-activated circRPPH1 contributes to glioma stemness.		circRPPH1	hsa_circ_RPPH1	RPPH1	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; Microarray	"circRPPH1 is up-regulated in glioma cells, glioma cell spheres, and glioma tissues based on RT-qPCR and online dataset analysis. Functionally, circRPPH1 promotes glioma stemness, including CSC marker expression, sphere formation, ALDH activity, and tumor-initiating capacity in vivo. Mechanistically, c-FOS binds the circRPPH1 promoter and transcriptionally activates circRPPH1 expression, forming a c-FOS/circRPPH1 regulatory axis."	0.7281
36455645	Neuropharmacology	2023	CircRalgapa1 facilitates morphine tolerance via miR-873a-5p/A20 axis in mice.		circRalgapa1 / circRNA_014599	mmu_circ_Ralgapa1	Ralgapa1	morphine tolerance	MONDO:0005530	opiate dependence	down-regulated	RT-qPCR; ISH; Microarray	"circRalgapa1 is a mouse circRNA derived from exon 34 of Ralgapa1 and is down-regulated in the spinal cord during morphine tolerance. It is mainly localized in neuronal cytoplasm, where it sponges miR-873a-5p to relieve repression of A20/TNFAIP3, thereby modulating NF-kappaB-related neuroimmune activation. Restoring circRalgapa1 expression attenuates morphine tolerance formation and partially reverses established morphine tolerance, suggesting therapeutic potential."	0.689
36456770	Molecular biology reports	2023	High percentage of Cancer Stem cells in metastatic locations: Upregulation of cicBIRC6 in highly metastatic breast Cancer Subline.	hsa_circ_0000989	CircBIRC6	hsa_circ_BIRC6	BIRC6	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"This study found that cicBIRC6/circBIRC6 was significantly upregulated in metastatic breast tumor cells compared with primary tumor cells, with higher expression in brain metastatic 4T1B cells than lung metastatic 4T1L cells. The authors proposed that elevated circBIRC6 is associated with increased spheroid formation, stemness, and aggressiveness of metastatic breast cancer cells, suggesting potential value as a marker of breast cancer stem cells."	0.3513
36459268	Molecular and cellular biochemistry	2023	"CircPACRGL promoted cell proliferation, migration and invasion as well as inhibited cell apoptosis in colorectal cancer via regulation of the miR-330-3p/CNBP axis."		circPACRGL	hsa_circ_PACRGL	PACRGL	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circPACRGL is up-regulated in colorectal cancer tissues and cells. It promotes CRC proliferation, migration, invasion and in vivo tumor growth while suppressing apoptosis, mainly by sponging miR-330-3p to increase CNBP expression. The study suggests circPACRGL may serve as a potential therapeutic target for colorectal cancer."	0.8299
36459832	"Pathology, research and practice"	2023	Circ_0001686 knockdown suppresses tumorigenesis and enhances radiosensitivity in esophagus cancer through regulating miR-876-5p/SPIN1 axis.	hsa_circ_0001686	circ_0001686	hsa_circ_MPP6	MPP6	esophageal cancer	MONDO:0007576	esophageal cancer	up-regulated	RT-qPCR	"circ_0001686 is up-regulated in esophageal cancer tissues and cells and is further elevated after irradiation. It promotes malignant phenotypes and radioresistance by sponging miR-876-5p to up-regulate SPIN1, while circ_0001686 knockdown suppresses tumor growth and enhances radiosensitivity in vitro and in vivo. High circ_0001686 expression is associated with worse overall survival."	0.8071
36460812	Molecular biotechnology	2023	Hsa_Circ_0134426 Attenuates the Malignant Biological Behaviors of Multiple Myeloma by Suppressing miR-146b-3p to Upregulate NDNF.	hsa_circ_0134426	circ_0134426	hsa_circ_GRB10	GRB10	multiple myeloma / MM	MONDO:0009693	plasma cell myeloma	down-regulated	RT-qPCR	"hsa_circ_0134426 is downregulated in multiple myeloma bone marrow samples and cell lines and functions as a tumor suppressor. It inhibits MM cell proliferation, colony formation, migration, EMT-related malignant behavior, and xenograft tumor growth by sponging miR-146b-3p and relieving repression of NDNF."	0.7795
36462326	Pharmacological research	2023	The circHMGCS1-miR-205-5p-ErBB3 axis mediated the Sanggenon C-induced anti-proliferation effects on human prostate cancer.	hsa_circ_0072386	circHMGCS1 / circRNA 0072386	hsa_circ_HMGCS1	hmgcs1	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR; ISH; Microarray	"circHMGCS1 is up-regulated in prostate cancer and is associated with higher malignancy. It promotes PCa cell proliferation and counteracts Sanggenon C-induced apoptosis and G0/G1 arrest by sponging miR-205-5p, thereby maintaining ErBB3 expression and activating PI3K/AKT signaling. SC exerts anti-tumor effects by suppressing circHMGCS1, which releases miR-205-5p to downregulate ErBB3 and induce cell-cycle arrest and apoptosis."	0.8207
36462338	International immunopharmacology	2023	Comprehensive evaluation of circRNAs in cirrhotic cardiomyopathy before and after liver transplantation.		circ-ASAP1	hsa_circ_ASAP1	ASAP1	cirrhotic cardiomyopathy / CCM	MONDO:0018932	cirrhotic cardiomyopathy	up-regulated	RT-qPCR; RNA-seq	"circ-ASAP1 was significantly downregulated after liver transplantation compared with before transplantation in CCM patients, consistent with RNA sequencing and qRT-PCR. The authors propose that circ-ASAP1 may be an important circRNA related to CCM occurrence/development and a potential biomarker for prognosis, diagnosis, and treatment."	0.4032
36462338	International immunopharmacology	2023	Comprehensive evaluation of circRNAs in cirrhotic cardiomyopathy before and after liver transplantation.		circ-N4BP2L2	hsa_circ_N4BP2L2	N4BP2L2	cirrhotic cardiomyopathy / CCM	MONDO:0018932	cirrhotic cardiomyopathy	up-regulated	RT-qPCR; RNA-seq	"circ-N4BP2L2 was significantly downregulated after liver transplantation in CCM patients, consistent with RNA sequencing and qRT-PCR results. The study supports its differential expression association with CCM before and after liver transplantation, but does not provide a specific mechanistic validation for this circRNA."	0.4032
36462338	International immunopharmacology	2023	Comprehensive evaluation of circRNAs in cirrhotic cardiomyopathy before and after liver transplantation.		circ-EXOC6B	hsa_circ_EXOC6B	EXOC6B	cirrhotic cardiomyopathy / CCM	MONDO:0018932	cirrhotic cardiomyopathy	up-regulated	RT-qPCR; RNA-seq	"circ-EXOC6B was significantly downregulated after liver transplantation in CCM patients, consistent with RNA sequencing and qRT-PCR results. The study supports its differential expression association with CCM before and after liver transplantation, but does not provide a specific mechanistic validation for this circRNA."	0.4032
36462338	International immunopharmacology	2023	Comprehensive evaluation of circRNAs in cirrhotic cardiomyopathy before and after liver transplantation.		21:37420299|374728809(circ-DYRK1A) / circ-DYRK1A	hsa_circ_DYRK1A	DYRK1A	cirrhotic cardiomyopathy / CCM	MONDO:0018932	cirrhotic cardiomyopathy	up-regulated	RNA-seq	"circ-DYRK1A was reported to decrease after liver transplantation, implying higher expression in the CCM state before transplantation. It was predicted to regulate hsa-miR-483-3p within a circRNA-miRNA-mRNA network potentially affecting cardiac structure and function in CCM."	0.348
36462557	Transplant immunology	2023	"Circ_0000069 contributes to the growth, metastasis and glutamine metabolism in renal cell carcinoma (RCC) via regulating miR-125a-5p-dependent SLC1A5 expression."	hsa_circ_0000069	circ_0000069 / hsa_circRNA_100213			renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR	"circ_0000069 is up-regulated in RCC tissues and cell lines and acts as a tumor-promoting circRNA. Its knockdown suppresses proliferation, invasion, migration, glutamine metabolism and xenograft tumor growth while promoting apoptosis, mainly through the circ_0000069/miR-125a-5p/SLC1A5 regulatory axis."	0.7892
36472132	Biomaterials science	2023	Engineered cell-overexpression of circular RNA hybrid hydrogels promotes healing of calvarial defects.	hsa_circ_0003376	circ-CTTN	hsa_circ_CTTN	CTTN	bone defects	MONDO:0005497	bone development disease	up-regulated	RNA-seq	"This study identified circ-CTTN as a pro-osteogenic circRNA in hUCMSCs. Engineered overexpression of circ-CTTN increased osteogenic markers and mineralization in vitro, and hUCMSC/GelMA hydrogels overexpressing circ-CTTN improved bone repair in a rat calvarial defect model."	0.5546
36473706	Human & experimental toxicology	2022	Hsa_circ_0019054 up-regulates HIF1A through sequestering miR-340-5p to promote the tumorigenesis of intrahepatic cholangiocarcinoma.	hsa_circ_0019054		hsa_circ_ATAD1	ATAD1	intrahepatic cholangiocarcinoma / ICC	MONDO:0003210	intrahepatic cholangiocarcinoma	up-regulated	RT-qPCR	"Hsa_circ_0019054/hsa_circ_0,019,054 is up-regulated in ICC tissues and cells and functions as an oncogenic circRNA. It promotes ICC proliferation, cell cycle progression, glycolysis and xenograft tumor growth while suppressing apoptosis, mainly by sponging miR-340-5p to up-regulate HIF1A. Its inhibition is proposed as a potential therapeutic strategy for ICC."	0.8324
36476974	"Shock (Augusta, Ga.)"	2023	CIRCKLHL2 KNOCKDOWN ALLEVIATES SEPSIS-INDUCED ACUTE LUNG INJURY BY REGULATING MIR-29B-3P MEDIATED ROCK1 EXPRESSION DOWN-REGULATION.	mmu_circ_0001679	circKlhl2	mmu_circ_Klhl2	Klhl2	sepsis-induced acute lung injury	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR	"circKlhl2 is up-regulated in LPS-induced sepsis-ALI mouse lung tissues and LPS-treated MPVECs. Its knockdown protects against lung injury and endothelial cell dysfunction by relieving proliferation arrest and reducing apoptosis and inflammatory cytokine release. Mechanistically, circKlhl2 regulates the miR-29b-3p/ROCK1 axis, and the authors propose it as a potential biomarker for sepsis-induced ALI."	0.6585
36481473	Reproductive biology	2023	Circ_0021573 acts as a competing endogenous RNA to promote the malignant phenotypes of human ovarian cancer cells.	hsa_circ_0021573	circ_0021573	hsa_circ_QSER1	QSER1	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circ_0021573 is up-regulated in human ovarian cancer tissues and cell lines. It promotes malignant phenotypes by sponging miR-936 and thereby increasing CUL4B expression, supporting proliferation, migration, invasion and tumor growth while suppressing apoptosis. The study suggests circ_0021573 may serve as a diagnostic biomarker and therapeutic target for ovarian cancer."	0.8299
36482494	Journal of biochemical and molecular toxicology	2023	Hsa_circ_0000119 promoted ovarian cancer development via enhancing the methylation of CDH13 by sponging miR-142-5p.	hsa_circ_0000119	circMAN1A2	hsa_circ_MAN1A2	MAN1A2	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"hsa_circ_0000119 is up-regulated in ovarian cancer tissues and cell lines. It promotes tumor growth and ovarian cancer cell proliferation, migration, and invasion by sponging miR-142-5p, thereby increasing DNMT1 expression and enhancing CDH13 methylation/repression. The study proposes hsa_circ_0000119 as a potential therapeutic target for ovarian cancer."	0.7177
36482742	"Cell cycle (Georgetown, Tex.)"	2023	CircSCN8A suppresses malignant progression and induces ferroptosis in non-small cell lung cancer by regulating miR-1290/ACSL4 axis.	hsa_circ_0026337	circSCN8A	hsa_circ_SCN8A	SCN8A	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"CircSCN8A is down-regulated in NSCLC tissues and cells, and low expression is associated with aggressive clinicopathological features and poorer overall survival. Functionally, circSCN8A acts as a tumor suppressor by inhibiting proliferation, migration, invasion, EMT/metastasis and xenograft growth while promoting ferroptosis. Mechanistically, it sponges miR-1290 to enhance ACSL4 expression, forming a circSCN8A/miR-1290/ACSL4 ceRNA axis."	0.8824
36484173	Human & experimental toxicology	2022	CircLPAR3 knockdown suppresses esophageal squamous cell carcinoma cell oncogenic phenotypes and Warburg effect through miR-873-5p/LDHA axis.	hsa_circ_0004390	circRNA lysophosphatidic acid receptor 3 (circLPAR3) / CircLPAR3	hsa_circ_LPAR3	LPAR3	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"circLPAR3 is up-regulated in ESCC tissues and cell lines and its high expression is associated with adverse clinicopathological features and shorter overall survival. Functionally, circLPAR3 promotes Warburg effect, proliferation, migration, invasion, metastasis, and tumor growth while inhibiting apoptosis. Mechanistically, it acts as a miR-873-5p sponge to increase LDHA expression, forming a circLPAR3/miR-873-5p/LDHA regulatory axis."	0.8535
36484486	"Journal of chemotherapy (Florence, Italy)"	2023	Depletion of circPDSS1 inhibits ITGA11 production to confer cisplatin sensitivity through miR-515-5p in gastric cancer.	hsa_circ_0093398	circ_0093398 / circPDSS1	hsa_circ_PDSS1	PDSS1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circPDSS1 is up-regulated in cisplatin-resistant gastric cancer tissues and cells. It promotes DDP resistance and malignant phenotypes by sponging miR-515-5p to increase ITGA11 expression, while circPDSS1 knockdown enhances DDP sensitivity in vitro and in a xenograft model."	0.8443
36484975	Journal of molecular neuroscience : MN	2022	Profiling and Bioinformatics Analyses of Differential Circular RNA Expression in Glioblastoma Multiforme Cells Under Hypoxia.	hsa_circ_0000745	circ-SPECC1	hsa_circ_SPECC1	SPECC1	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000745/circ-SPECC1 is up-regulated in hypoxic GBM cell lines and GBM tissues. Its knockdown suppresses GBM cell proliferation, migration, and invasion under hypoxia, suggesting a tumor-promoting role and potential value as a prognostic or therapeutic candidate."	0.7378
36484975	Journal of molecular neuroscience : MN	2022	Profiling and Bioinformatics Analyses of Differential Circular RNA Expression in Glioblastoma Multiforme Cells Under Hypoxia.	hsa_circ_0020093				glioblastoma / GBM	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0020093 is down-regulated in hypoxic GBM cell lines and in GBM tissues compared with para-tumor tissues. The study supports its dysregulation in hypoxic GBM and includes it in a predicted HIF-1alpha-centered circRNA-miRNA-mRNA network, but does not report individual functional assays for this circRNA."	0.5994
36484975	Journal of molecular neuroscience : MN	2022	Profiling and Bioinformatics Analyses of Differential Circular RNA Expression in Glioblastoma Multiforme Cells Under Hypoxia.	hsa_circ_0020094				glioblastoma / GBM	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0020094 is down-regulated in hypoxic GBM cell lines and in GBM tissues compared with para-tumor tissues. The study validates its differential expression and includes it in predicted HIF-1alpha-centered ceRNA network analysis, but reports no individual functional assay."	0.5994
36484975	Journal of molecular neuroscience : MN	2022	Profiling and Bioinformatics Analyses of Differential Circular RNA Expression in Glioblastoma Multiforme Cells Under Hypoxia.	hsa_circ_0000943		hsa_circ_ARHGAP35	ARHGAP35	glioblastoma / GBM	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0000943 is down-regulated in hypoxic GBM cell lines and in GBM tissues. The authors linked it to ARHGAP35 and suggested that it may participate in GBM malignant phenotypes under hypoxia, though its specific mechanism was not experimentally validated."	0.5994
36484975	Journal of molecular neuroscience : MN	2022	Profiling and Bioinformatics Analyses of Differential Circular RNA Expression in Glioblastoma Multiforme Cells Under Hypoxia.	hsa_circ_0004874				glioblastoma / GBM	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0004874 is down-regulated in hypoxic GBM cell lines and in GBM tissues compared with para-tumor tissues. It was experimentally validated for expression and circRNA features, and was included in predicted HIF-1alpha-centered circRNA-miRNA-mRNA network analysis."	0.5994
36484975	Journal of molecular neuroscience : MN	2022	Profiling and Bioinformatics Analyses of Differential Circular RNA Expression in Glioblastoma Multiforme Cells Under Hypoxia.	hsa_circ_0002359				glioblastoma / GBM	MONDO:0018177	glioblastoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0002359 is down-regulated in hypoxic GBM cell lines and in GBM tissues compared with para-tumor tissues. The study validates its differential expression and circular structure, and suggests possible involvement in hypoxia-related GBM progression through predicted circRNA-miRNA-mRNA networks."	0.5994
36495510	"Cellular and molecular biology (Noisy-le-Grand, France)"	2022	Circ_0022340 promotes colorectal cancer progression via HNRNPC/EBF1/SYT7 or miR-382-5p/ELK1 axis.	hsa_circ_0022340	circ_0022340	hsa_circ_SYT7	SYT7	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0022340 is up-regulated in colorectal cancer cells and acts as an oncogenic circRNA. It promotes CRC proliferation, migration and tumor growth by recruiting HNRNPC to stabilize EBF1 mRNA and activate SYT7, and by sponging miR-382-5p to increase ELK1 expression. The study suggests circ_0022340 may be a potential therapeutic target for CRC."	0.8597
36496205	Experimental and molecular pathology	2023	"Expression analysis of hsa_circ_0020397, hsa_circ_0005986, hsa_circ_0003028, and hsa_circ_0006990 in renal cell carcinoma."	hsa_circ_0020397		hsa_circ_DOCK1	DOCK1	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	down-regulated	RT-qPCR	"hsa_circ_0020397 was significantly downregulated in RCC tissues and in ccRCC samples. The study predicts that it may act as a ceRNA in RCC, particularly through hsa-miR-150/CASP8 and hsa-miR-34a/CYCS-related axes, and its downregulation may contribute to RCC metastasis."	0.4685
36496205	Experimental and molecular pathology	2023	"Expression analysis of hsa_circ_0020397, hsa_circ_0005986, hsa_circ_0003028, and hsa_circ_0006990 in renal cell carcinoma."	hsa_circ_0005986		hsa_circ_PRDM2	PRDM2	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	down-regulated	RT-qPCR	"hsa_circ_0005986 was significantly downregulated in RCC tissues and in ccRCC samples. The paper predicts that it may function as a ceRNA by sponging hsa-mir-21 and hsa-mir-34a to regulate CASP8, CCND1 and CYCS, with a potentially important hsa_circ_0005986/hsa-mir-34a/CYCS axis in RCC progression."	0.4685
36496205	Experimental and molecular pathology	2023	"Expression analysis of hsa_circ_0020397, hsa_circ_0005986, hsa_circ_0003028, and hsa_circ_0006990 in renal cell carcinoma."	hsa_circ_0006990		hsa_circ_VAPA	VAPA	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	down-regulated	RT-qPCR	"hsa_circ_0006990 was significantly downregulated in RCC tissues and in ccRCC samples, although it showed higher expression in oncocytoma type relative to other RCC subtypes. The study predicts that it may affect RCC development through a ceRNA mechanism involving hsa-mir-494 and hsa-mir-34a with CCND1 and CYCS."	0.4685
36502647	"Legal medicine (Tokyo, Japan)"	2023	CircSMARCC1 and CircLRBA are potential biomarkers in forensic postmortem diagnosis of acute myocardial infarction.		circSMARCC1	hsa_circ_SMARCC1	SMARCC1	acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR; Microarray	"circSMARCC1 was screened from GEO AMI circRNA expression data and validated as a stable circular RNA. Its expression increased in mouse AMI models and in human forensic MI and early-MI autopsy cases, supporting its value as a postmortem diagnostic biomarker for AMI."	0.7241
36502647	"Legal medicine (Tokyo, Japan)"	2023	CircSMARCC1 and CircLRBA are potential biomarkers in forensic postmortem diagnosis of acute myocardial infarction.		circSMARCC1	mmu_circ_SMARCC1	SMARCC1	acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR; Microarray	"circSMARCC1 was screened from GEO AMI circRNA expression data and validated as a stable circular RNA. Its expression increased in mouse AMI models and in human forensic MI and early-MI autopsy cases, supporting its value as a postmortem diagnostic biomarker for AMI."	0.7241
36502647	"Legal medicine (Tokyo, Japan)"	2023	CircSMARCC1 and CircLRBA are potential biomarkers in forensic postmortem diagnosis of acute myocardial infarction.		circLRBA	hsa_circ_LRBA	LRBA	acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	down-regulated	RT-qPCR; Microarray	"circLRBA was screened from GEO AMI circRNA expression data and validated as a stable circular RNA. Its expression decreased in mouse AMI models and in human forensic MI and early-MI autopsy cases, supporting its value as a postmortem diagnostic biomarker for AMI."	0.7241
36502647	"Legal medicine (Tokyo, Japan)"	2023	CircSMARCC1 and CircLRBA are potential biomarkers in forensic postmortem diagnosis of acute myocardial infarction.		circLRBA	mmu_circ_LRBA	LRBA	acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	down-regulated	RT-qPCR; Microarray	"circLRBA was screened from GEO AMI circRNA expression data and validated as a stable circular RNA. Its expression decreased in mouse AMI models and in human forensic MI and early-MI autopsy cases, supporting its value as a postmortem diagnostic biomarker for AMI."	0.7241
36503048	The international journal of biochemistry & cell biology	2023	CircSETD3 mediates acquired resistance to gefitinib in non-small lung cancer cells by FXR1/ECT2 pathway.		circSETD3	hsa_circ_SETD3	SETD3	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"This study shows that circSETD3 is up-regulated in gefitinib-resistant NSCLC cells and patient plasma samples and can serve as a potential predictive biomarker for gefitinib resistance. Functionally, circSETD3 promotes gefitinib resistance by increasing cell viability and suppressing apoptosis in vitro and in cell line-derived xenograft models. Mechanistically, circSETD3 binds FXR1 in the cytoplasm, enhances FXR1-mediated ECT2 mRNA decay, and suppresses the pro-apoptotic JNK/Bim pathway."	0.823
36503078	Acta biomaterialia	2023	Hypoxia-pretreated ADSC-derived exosome-embedded hydrogels promote angiogenesis and accelerate diabetic wound healing.	mmu_circ_0001100	circ-Snhg11	mmu_circ_Snhg11	Snhg11	diabetic wound	MONDO:0005015	diabetes mellitus	up-regulated	RT-qPCR; RNA-seq	"circ-Snhg11 is enriched in hypoxia-pretreated ADSC-derived exosomes and mediates the enhanced therapeutic effect of GelMA-HExo hydrogels in diabetic wound healing. It promotes endothelial cell proliferation, migration/invasion, tube formation and angiogenesis through a miR-144-3p/NFE2L2/HIF1 alpha regulatory axis, thereby accelerating wound repair in diabetic mice."	0.742
36503162	Cellular signalling	2023	circPHF16 suppresses prostate cancer metastasis via modulating miR-581/RNF128/Wnt/beta-catenin pathway.		circPHF16	hsa_circ_PHF16	PHF16	prostate cancer / PCa	MONDO:0008315	prostate cancer	down-regulated	RT-qPCR; Microarray	"circPHF16 is downregulated in prostate cancer and acts as a tumor-suppressive circRNA. It inhibits prostate cancer cell migration, invasion and metastasis by sponging miR-581, upregulating RNF128, and suppressing Wnt/beta-catenin signaling."	0.8516
36503469	Recent patents on anti-cancer drug discovery	2023	Gene Expression Network and Circ_0008012 Promote Progression in MLL/AF4 Positive Acute Lymphoblastic Leukemia.	hsa_circ_0008012	Circ_0008012	hsa_circ_NF-kappaB1	NF-kappaB1	acute lymphoblastic leukemia / ALL	MONDO:0004967	acute lymphoblastic leukemia	up-regulated	RT-qPCR	"circ_0008012 is an NF-kappaB1-derived circRNA that is up-regulated in MLL/AF4-positive acute lymphoblastic leukemia patient samples and cells. Its knockdown decreases MLL/AF4-positive leukemia cell viability and promotes apoptosis. Mechanistically, the study suggests that circ_0008012 binds IKKbeta and modulates the NF-kappaB/P300 pathway, supporting leukemia progression and indicating potential therapeutic value."	0.6479
36508830	Ecotoxicology and environmental safety	2023	CircCDR1as mediates PM2.5-induced lung cancer progression by binding to SRSF1.		circCDR1as	hsa_circ_CDR1	CDR1	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; Microarray	"circCDR1as is upregulated in PM2.5-exposed lung cancer cells and promotes PM2.5-induced malignant progression. Mechanistically, it binds SRSF1, inhibits PARK2-mediated ubiquitination and degradation of SRSF1, regulates VEGFA mRNA splicing, and activates Wnt/beta-catenin signaling to enhance malignant behavior and suppress apoptosis."	0.8207
36513585	Clinical breast cancer	2023	Circ_0001777 Affects Triple-negative Breast Cancer Progression Through the miR-95-3p/AKAP12 Axis.	hsa_circ_0001777	Circ_0001777	hsa_circ_ESYT2	ESYT2	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	down-regulated	RT-qPCR	"circ_0001777 is down-regulated in TNBC tissues and cell lines and mainly localized in the cytoplasm. It functions as a tumor suppressor by sponging miR-95-3p to upregulate AKAP12, thereby inhibiting proliferation, migration, invasion, EMT-related changes and xenograft tumor growth while promoting apoptosis. Higher circ_0001777 expression is associated with better overall survival in TNBC patients."	0.8428
36515277	Histology and histopathology	2023	Hsa_circ_0026344 suppresses gastric cancer progression via modulating the miR-1290/FBP2 axis.	hsa_circ_0026344	circ_0026344			gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"hsa_circ_0026344/circ_0026344 is down-regulated in gastric cancer tissues and cell lines. Its overexpression suppresses GC cell proliferation, migration, invasion and xenograft tumor growth by sponging miR-1290 and upregulating FBP2, suggesting potential therapeutic relevance."	0.7548
36515407	Phytotherapy research : PTR	2023	Antidepressant-like effects of geniposide in chronic unpredictable mild stress-induced mice by regulating the circ_0008405/miR-25-3p/Gata2 and Oip5os1/miR-25-3p/Gata2 networks.	hsa_circ_0015067	circ_0008405			depression	MONDO:0002050	depressive disorder	down-regulated	RT-qPCR; Microarray	"circ_0008405 is downregulated in hippocampal tissues of CUMS mice, while its human homolog hsa_circ_0015067 is reduced in blood samples from depression patients. GP treatment upregulates circ_0008405, enabling it to sponge miR-25-3p and promote Gata2 expression; silencing circ_0008405 weakens GP-mediated antidepressant-like effects and increases hippocampal neuronal apoptosis."	0.717
36515407	Phytotherapy research : PTR	2023	Antidepressant-like effects of geniposide in chronic unpredictable mild stress-induced mice by regulating the circ_0008405/miR-25-3p/Gata2 and Oip5os1/miR-25-3p/Gata2 networks.		circ_0008405			depression	MONDO:0002050	depressive disorder	down-regulated	RT-qPCR; Microarray	"circ_0008405 is downregulated in hippocampal tissues of CUMS mice, while its human homolog hsa_circ_0015067 is reduced in blood samples from depression patients. GP treatment upregulates circ_0008405, enabling it to sponge miR-25-3p and promote Gata2 expression; silencing circ_0008405 weakens GP-mediated antidepressant-like effects and increases hippocampal neuronal apoptosis."	0.717
36519254	Hepatology research : the official journal of the Japan Society of Hepatology	2023	circTMEM181 upregulates ARHGAP29 to inhibit hepatocellular carcinoma migration and invasion by sponging miR-519a-5p.		circTMEM181	hsa_circ_TMEM181	TMEM181	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; RNA-seq	"circTMEM181 is a human TMEM181-derived circRNA that is downregulated in HCC tissues and is associated with patient overall survival. It suppresses HCC cell migration and invasion by sponging miR-519a-5p and increasing ARHGAP29 protein expression, forming the circTMEM181/miR-519a-5p/ARHGAP29 regulatory axis."	0.8566
36519522	Histology and histopathology	2023	Circ-CCS regulates oxaliplatin resistance via targeting miR-874-3p/HK2 axis in colorectal cancer.		circ-CCS / Circular RNA copper chaperone for superoxide dismutase	hsa_circ_CCS	CCS	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circ-CCS is up-regulated in colorectal cancer and especially in oxaliplatin-resistant CRC tissues and cells. Functionally, circ-CCS promotes oxaliplatin resistance, proliferation, migration, invasion and glycolysis metabolism while suppressing apoptosis; its knockdown inhibits tumor growth and improves oxaliplatin sensitivity in vivo. Mechanistically, circ-CCS acts through the miR-874-3p/HK2 axis."	0.786
36524862	Current eye research	2023	"Circ_0047835 Combines with miR-144-3p to Promote the Proliferation, Invasion, Migration, and Fibrosis of TGF-beta1-Treated Human Tenon's Capsule Fibroblasts by Upregulating SP1."	hsa_circ_0047835	circ_0047835	hsa_circ_PMAIP1	PMAIP1	glaucoma	MONDO:0005041	glaucoma	up-regulated	RT-qPCR	"circ_0047835 is upregulated in glaucoma Tenon's tissues and TGF-beta1-treated human Tenon's capsule fibroblasts. It promotes proliferation, invasion, migration, and fibrosis by sponging miR-144-3p and increasing SP1 expression, suggesting a potential therapeutic or biomarker role in glaucoma-related postoperative fibrosis."	0.7591
36526188	The Science of the total environment	2023	Circ_002363 is regulated by the RNA binding protein BCAS2 and inhibits neodymium oxide nanoparticle-induced DNA damage by non-homologous end-joining repair.		circ_002363	hsa_circ_DNA2	DNA2	pulmonary toxicity	MONDO:0005275	lung disorder	down-regulated	RT-qPCR; RNA-seq	"Circ_002363 is downregulated after NPs-Nd 2 O 3 exposure in 16HBE cells, exposed rats and occupational workers. It suppresses nanoparticle-induced DNA damage by promoting the NHEJ repair pathway through interactions with PARP1, Ku70, Ku80 and Rad50, while BCAS2-mediated regulation of Pre-DNA2 contributes to its reduced formation."	0.8635
36526188	The Science of the total environment	2023	Circ_002363 is regulated by the RNA binding protein BCAS2 and inhibits neodymium oxide nanoparticle-induced DNA damage by non-homologous end-joining repair.		circ_002363	rno_circ_DNA2	DNA2	pulmonary toxicity	MONDO:0005275	lung disorder	down-regulated	RT-qPCR; RNA-seq	"Circ_002363 is downregulated after NPs-Nd 2 O 3 exposure in 16HBE cells, exposed rats and occupational workers. It suppresses nanoparticle-induced DNA damage by promoting the NHEJ repair pathway through interactions with PARP1, Ku70, Ku80 and Rad50, while BCAS2-mediated regulation of Pre-DNA2 contributes to its reduced formation."	0.8635
36526188	The Science of the total environment	2023	Circ_002363 is regulated by the RNA binding protein BCAS2 and inhibits neodymium oxide nanoparticle-induced DNA damage by non-homologous end-joining repair.		circ_020637			pulmonary toxicity	MONDO:0005275	lung disorder	up-regulated	RT-qPCR; RNA-seq	"Circ_020637 was identified by RNA-seq and validated by qRT-PCR as upregulated in NPs-Nd 2 O 3-treated 16HBE cells. Its expression also showed a dose-dependent relationship with NPs-Nd 2 O 3 concentration, but no mechanistic or functional experiments were reported for this circRNA."	0.1904
36526188	The Science of the total environment	2023	Circ_002363 is regulated by the RNA binding protein BCAS2 and inhibits neodymium oxide nanoparticle-induced DNA damage by non-homologous end-joining repair.		circ_000409			pulmonary toxicity	MONDO:0005275	lung disorder	up-regulated	RT-qPCR; RNA-seq	"Circ_000409 was identified by RNA-seq and validated by qRT-PCR as upregulated in NPs-Nd 2 O 3-treated 16HBE cells. The paper did not report functional assays, interacting partners or a molecular mechanism for this circRNA."	0.1904
36526188	The Science of the total environment	2023	Circ_002363 is regulated by the RNA binding protein BCAS2 and inhibits neodymium oxide nanoparticle-induced DNA damage by non-homologous end-joining repair.		circ_004082			pulmonary toxicity	MONDO:0005275	lung disorder	down-regulated	RT-qPCR; RNA-seq	"Circ_004082 was identified by RNA-seq and validated by qRT-PCR as downregulated in NPs-Nd 2 O 3-treated 16HBE cells. Its expression showed a dose-dependent relationship with NPs-Nd 2 O 3 concentration, but no functional or mechanistic experiments were reported for this circRNA."	0.1904
36526188	The Science of the total environment	2023	Circ_002363 is regulated by the RNA binding protein BCAS2 and inhibits neodymium oxide nanoparticle-induced DNA damage by non-homologous end-joining repair.		circ_008891			pulmonary toxicity	MONDO:0005275	lung disorder	down-regulated	RT-qPCR; RNA-seq	"Circ_008891 was identified by RNA-seq and validated by qRT-PCR as downregulated in NPs-Nd 2 O 3-treated 16HBE cells. Its expression showed a dose-dependent relationship with NPs-Nd 2 O 3 concentration, but no downstream mechanism or disease-related function was tested."	0.1904
36526188	The Science of the total environment	2023	Circ_002363 is regulated by the RNA binding protein BCAS2 and inhibits neodymium oxide nanoparticle-induced DNA damage by non-homologous end-joining repair.		circ_014931			pulmonary toxicity	MONDO:0005275	lung disorder	down-regulated	RT-qPCR; RNA-seq	"Circ_014931 was identified by RNA-seq and validated by qRT-PCR as downregulated in NPs-Nd 2 O 3-treated 16HBE cells. Its expression showed a dose-dependent relationship with NPs-Nd 2 O 3 concentration, but the study did not further test its function or mechanism."	0.1904
36528242	Cellular signalling	2023	Microarray profiling of circular RNAs in LPS-induced Beas-2B cells and identification of circ_2979 as a potential biomarker for ARDS.		circ_2979			acute respiratory distress syndrome / ARDS	MONDO:0006502	acute respiratory distress syndrome	up-regulated	RT-qPCR; RNA-seq	"circ_2979 was up-regulated in LPS-induced Beas-2B cells and in serum from ARDS patients. Its serum expression correlated with ARDS-related clinical indicators, supporting its potential value as a diagnostic and prognostic biomarker, although no significant survival difference was observed."	0.4679
36528242	Cellular signalling	2023	Microarray profiling of circular RNAs in LPS-induced Beas-2B cells and identification of circ_2979 as a potential biomarker for ARDS.		circ_5438			acute respiratory distress syndrome / ARDS	MONDO:0006502	acute respiratory distress syndrome	up-regulated	RT-qPCR; RNA-seq	"circ_5438 was identified as up-regulated in LPS-induced Beas-2B cells by RNA-seq and was validated by RT-PCR. The study did not report a specific mechanism, interacting partners, or clinical association for this circRNA."	0.1904
36528242	Cellular signalling	2023	Microarray profiling of circular RNAs in LPS-induced Beas-2B cells and identification of circ_2979 as a potential biomarker for ARDS.		circ_4557			acute respiratory distress syndrome / ARDS	MONDO:0006502	acute respiratory distress syndrome	up-regulated	RT-qPCR; RNA-seq	"circ_4557 was identified as up-regulated in LPS-induced Beas-2B cells by RNA-seq and was validated by RT-PCR. The study did not provide a specific biological mechanism, interaction partner, or clinical validation for this circRNA."	0.1904
36528242	Cellular signalling	2023	Microarray profiling of circular RNAs in LPS-induced Beas-2B cells and identification of circ_2979 as a potential biomarker for ARDS.		circ_2066			acute respiratory distress syndrome / ARDS	MONDO:0006502	acute respiratory distress syndrome	down-regulated	RT-qPCR; RNA-seq	"circ_2066 was identified as down-regulated in LPS-induced Beas-2B cells by RNA-seq and was validated by RT-PCR. No specific molecular mechanism, interacting miRNA, pathway, or clinical relevance was reported for circ_2066."	0.1904
36528242	Cellular signalling	2023	Microarray profiling of circular RNAs in LPS-induced Beas-2B cells and identification of circ_2979 as a potential biomarker for ARDS.		circ_5431			acute respiratory distress syndrome / ARDS	MONDO:0006502	acute respiratory distress syndrome	dysregulated	RNA-seq	"circ_5431 was selected from RNA-seq data as a candidate differentially expressed circRNA in LPS-induced Beas-2B cells, but its RT-PCR result was inconsistent with the RNA-seq direction. Therefore, the evidence for its ARDS-related expression change is low and no specific mechanism or clinical role was established."	0.1155
36528986	"Pathology, research and practice"	2023	Exosome-mediated circTTLL5 transfer promotes hepatocellular carcinoma malignant progression through miR-136-5p/KIAA1522 axis.	hsa_circ_0032704	circTTLL5 / circular RNA tubulin tyrosine ligase like 5	hsa_circ_TTLL5	TTLL5	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circTTLL5 (hsa_circ_0032704), derived from TTLL5, is up-regulated in HCC tissues, cells and exosomes. Exosome-mediated circTTLL5 transfer promotes HCC proliferation, EMT, migration, invasion, metastasis and xenograft tumor growth while suppressing apoptosis. Mechanistically, circTTLL5 functions as a ceRNA that sponges miR-136-5p to relieve repression of KIAA1522, suggesting a potential therapeutic target in HCC."	0.78
36533720	Histology and histopathology	2023	CircRNA PDE3B regulates tumorigenicity via the miR-136-5p/MAP3K2 axis of esophageal squamous cell carcinoma.	hsa_circ_0000277	circ_PDE3B	hsa_circ_PDE3B	PDE3B	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"hsa_circ_0000277/circ_PDE3B is up-regulated in ESCC tissues and cells and mainly localizes to the cytoplasm. Functionally, circ_PDE3B promotes ESCC proliferation, migration, invasion, EMT-related marker changes, and xenograft tumor growth while suppressing apoptosis. Mechanistically, it acts as a miR-136-5p sponge to regulate MAP3K2 expression, suggesting a tumor-promoting circ_PDE3B/miR-136-5p/MAP3K2 axis."	0.8443
36536496	Journal of biochemical and molecular toxicology	2023	"Circ_0000284 upregulates RHPN2 to facilitate pancreatic cancer proliferation, metastasis, and angiogenesis through sponging miR-1179."	hsa_circ_0000284	circ_0000284 / circHIPK3	hsa_circ_HIPK3	HIPK3	pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"In pancreatic cancer, circ_0000284 is up-regulated in tumor tissues and cancer cell lines. It promotes proliferation, migration, invasion, angiogenesis, and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ_0000284 sponges miR-1179 to upregulate RHPN2, suggesting a circ_0000284/miR-1179/RHPN2 ceRNA axis and a potential therapeutic target."	0.8005
36537855	Diabetic medicine : a journal of the British Diabetic Association	2023	Bone marrow stromal cell-derived exosomal circular RNA improves diabetic foot ulcer wound healing by activating the nuclear factor erythroid 2-related factor 2 pathway and inhibiting ferroptosis.		circRNA-itchy E3 ubiquitin protein ligase / circ-ITCH	hsa_circ_ITCH		diabetic foot ulcer / DFU	MONDO:0005015	diabetes mellitus	down-regulated	RT-qPCR	"This study shows that circ-ITCH is down-regulated in DFU-related in vitro and in vivo models. BMSC-derived exosomal circ-ITCH promotes HUVEC viability and angiogenesis and improves DFU wound healing by recruiting TAF15 to stabilize Nrf2 mRNA, activating Nrf2 signaling and inhibiting ferroptosis."	0.73
36538242	Cell biology and toxicology	2023	CircSTK39 suppresses the proliferation and invasion of bladder cancer by regulating the miR-135a-5p/NR3C2-mediated epithelial-mesenchymal transition signaling pathway.	hsa_circ_0001079	circSTK39	hsa_circ_STK39	STK39	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"circSTK39/hsa_circ_0001079 is a human STK39-derived circRNA that is downregulated in bladder cancer tissues and cell lines. It acts as a tumor-suppressive circRNA by sponging miR-135a-5p, increasing NR3C2 expression, and inhibiting EMT-associated proliferation, migration, invasion, tumor growth, and metastasis. Higher circSTK39 expression is associated with longer overall survival, and the study proposes circSTK39 as a diagnostic and prognostic biomarker for BCa."	0.8981
36539364	Anti-cancer drugs	2023	Circ_0058608 contributes to the progression and taxol resistance of non-small cell lung cancer by sponging miR-1299 to upregulate GBP1.	hsa_circ_0058608	circ_0058608	hsa_circ_SP140L		non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0058608 is up-regulated in NSCLC and further elevated in taxol-resistant NSCLC tissues and cells. It promotes NSCLC proliferation, migration, invasion, EMT, tumor growth, and taxol resistance by sponging miR-1299 and upregulating GBP1; high expression is associated with poor patient survival."	0.7794
36539365	Anti-cancer drugs	2023	CircPIM3 regulates taxol resistance in non-small cell lung cancer via miR-338-3p/TNFAIP8 axis.	hsa_circ_0063877	circPIM3 	hsa_circ_PIM3	PIM3	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"This study identifies circPIM3 as an up-regulated circRNA in Tax-resistant NSCLC tissues and cells. circPIM3 promotes Tax resistance and malignant phenotypes by sponging miR-338-3p and increasing TNFAIP8, while circPIM3 silencing enhances Tax sensitivity in vitro and in a xenograft model. High circPIM3 expression is associated with poorer overall survival."	0.7793
36539369	Anti-cancer drugs	2023	Hsa_circ_0007380 silencing restrains the growth and enhances radiosensitivity in esophagus cancer by miR-644a/Spindlin 1 axis.	hsa_circ_0007380	circNSUN2 / circ_0007380	hsa_circ_NSUN2	NSUN2	esophageal cancer	MONDO:0007576	esophageal cancer	up-regulated	RT-qPCR	"Hsa_circ_0007380 is up-regulated in esophagus cancer tissues and cell lines. It acts as an oncogenic circRNA that promotes proliferation, tumor growth and radioresistance while inhibiting apoptosis, mainly through the hsa_circ_0007380/miR-644a/SPIN1 ceRNA axis. Silencing hsa_circ_0007380 enhances radiosensitivity, suggesting therapeutic potential in combined treatment for esophagus cancer."	0.8439
36540014	Microbiology and immunology	2023	Silencing of circ-NT5C2 retards the progression of IL-1beta-induced osteoarthritis in an in vitro cell model by targeting the miR-142-5p/NAMPT axis.	hsa_circ_0092516	circ-NT5C2 / circ_0092516	hsa_circ_NT5C2	NT5C2	osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circ-NT5C2 is upregulated in osteoarthritis and promotes disease progression. Mechanistically, it acts as a ceRNA that sponges miR-142-5p, relieving repression of NAMPT and thereby promoting inflammation, apoptosis, and reduced proliferation/ECM synthesis in IL-1beta-stimulated chondrocytes. Silencing circ-NT5C2 reverses these OA-like phenotypes in vitro."	0.7244
36541402	Journal of biochemical and molecular toxicology	2023	Circ_0018909 knockdown inhibits the development of pancreatic cancer via the miR-545-3p/FASN axis and reduces macrophage polarization to M2.	hsa_circ_0018909	circ_0018909	hsa_circ_VDAC2	VDAC2	pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR	"circ_0018909 is up-regulated in pancreatic cancer tissues and cells and is associated with advanced clinical stage. Functionally, circ_0018909 promotes pancreatic cancer cell proliferation, migration, invasion, EMT, tumor growth, and M2 macrophage polarization while inhibiting apoptosis. Mechanistically, it sponges miR-545-3p to increase FASN expression."	0.8299
36542208	Biochemical genetics	2023	Circ-IGF1R Affects the Progression of Colorectal Cancer by Activating the miR-362-5p/HMGB3-Mediated Wnt/beta-Catenin Signal Pathway.	hsa_circ_0005035	circRNA insulin growth factor 1 receptor / circ-IGF1R	hsa_circ_IGF1R	IGF1R	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"Circ-IGF1R is up-regulated in colorectal cancer tissues and cell lines and is associated with poorer overall survival. Functionally, circ-IGF1R promotes CRC cell proliferation, migration, invasion, glycolysis and xenograft tumor growth while suppressing apoptosis. Mechanistically, it acts as a miR-362-5p sponge to enhance HMGB3 expression and activate the Wnt/beta-catenin pathway."	0.8861
36542209	Biochemical genetics	2023	Circular RNA Circ_0005962 Contributes to Lung Adenocarcinoma Cell Proliferation and Stem Cell Formation Through Sponging of miR-3611 and Modulating CYP24A1 Expression.	hsa_circ_0005962	circ_0005962	hsa_circ_YWHAZ	YWHAZ	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"circ_0005962 is up-regulated in LUAD tissues and cell lines and is associated with advanced clinicopathologic features. Functionally, it promotes LUAD cell proliferation, cell cycle progression, stem-like sphere formation and xenograft tumor growth. Mechanistically, circ_0005962 functions as a ceRNA that sponges miR-3611 to increase CYP24A1 expression."	0.8324
36543889	Hypertension research : official journal of the Japanese Society of Hypertension	2023	Circ_0000284: A risk factor and potential biomarker for prehypertension and hypertension.	hsa_circ_0000284	circ_0000284 / cir-cHIPK3	hsa_circ_HIPK3	HIPK3	hypertension	MONDO:0005044	hypertensive disorder	up-regulated	RT-qPCR	"This study found that circ_0000284 is upregulated in peripheral blood during progression from normal blood pressure to prehypertension and hypertension. Its high expression is an independent risk factor and a potential diagnostic biomarker, and bioinformatics analyses suggest it may function as a miRNA sponge involved in hypertension-related biological processes."	0.459
36562080	"Genes, chromosomes & cancer"	2023	"circPVT1 and PVT1/AKT3 show a role in cell proliferation, apoptosis, and tumor subtype-definition in small cell lung cancer."	hsa_circ_0001821	circPVT1	hsa_circ_PVT1	PVT1	small cell lung cancer / SCLC	MONDO:0008433	small cell lung carcinoma	up-regulated	RT-qPCR; Northern Blot	"This study reports that circPVT1 is overexpressed in SCLC cell lines, especially MYC-amplified contexts. Functional overexpression experiments indicate that circPVT1 promotes proliferation, inhibits apoptosis, increases MYC/BCL2/YAP1, decreases POU2F3, and may contribute to SCLC tumorigenesis and subtype definition. circPVT1 is also detected in extracellular vesicles from SCLC cell lines, supporting potential biomarker relevance."	0.593
36562476	Molecular carcinogenesis	2023	"CircDUSP1 regulates tumor growth, metastasis, and paclitaxel sensitivity in triple-negative breast cancer by targeting miR-761/DACT2 signaling axis."	hsa_circ_0075043	circDUSP1	hsa_circ_DUSP1	DUSP1	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	down-regulated	RT-qPCR	"circDUSP1 is down-regulated in TNBC tissues and cell lines, and low expression is associated with advanced disease features and poorer survival. Functionally, circDUSP1 acts as a tumor suppressor that inhibits proliferation, invasion, metastasis and EMT while enhancing paclitaxel sensitivity. Mechanistically, it sponges miR-761 to upregulate the target gene DACT2."	0.8635
36562654	Cancer research	2023	CircPDIA4 Induces Gastric Cancer Progression by Promoting ERK1/2 Activation and Enhancing Biogenesis of Oncogenic circRNAs.		circPDIA4	hsa_circ_PDIA4	PDIA4	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circPDIA4 is a human PDIA4-derived circRNA that is up-regulated in gastric cancer and predicts poor survival. It promotes migration, invasion, EMT, metastasis, and ERK inhibitor resistance by sustaining ERK1/2 phosphorylation and by acting as a DHX9 decoy to enhance oncogenic circRNA biogenesis."	0.8961
36562654	Cancer research	2023	CircPDIA4 Induces Gastric Cancer Progression by Promoting ERK1/2 Activation and Enhancing Biogenesis of Oncogenic circRNAs.	hsa_circ_0001610	circ_0001610	hsa_circ_TNFRSF21	TNFRSF21	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0001610/circ_0001610 is up-regulated in gastric cancer tissues and is induced by circPDIA4 through a DHX9-dependent mechanism. Functional rescue experiments indicate that circ_0001610 contributes to circPDIA4-driven invasive activity in gastric cancer cells.	0.6102
36562654	Cancer research	2023	CircPDIA4 Induces Gastric Cancer Progression by Promoting ERK1/2 Activation and Enhancing Biogenesis of Oncogenic circRNAs.	hsa_circ_0005035	circ_0005035			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"circ_0005035 is one of the circPDIA4-induced candidate oncogenic circRNAs and is up-regulated in gastric cancer tissues. The paper reports expression validation and correlation with circPDIA4, but does not report individual functional assays for this circRNA."	0.4685
36562654	Cancer research	2023	CircPDIA4 Induces Gastric Cancer Progression by Promoting ERK1/2 Activation and Enhancing Biogenesis of Oncogenic circRNAs.	hsa_circ_0007052	circ_0007052			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"circ_0007052 is one of the circPDIA4-induced candidate oncogenic circRNAs and is up-regulated in gastric cancer tissues. The paper reports expression validation and correlation with circPDIA4, but does not report individual functional assays for this circRNA."	0.4685
36562654	Cancer research	2023	CircPDIA4 Induces Gastric Cancer Progression by Promoting ERK1/2 Activation and Enhancing Biogenesis of Oncogenic circRNAs.	hsa_circ_0002968	circ_0002968			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"circ_0002968 is one of the circPDIA4-induced candidate oncogenic circRNAs and is up-regulated in gastric cancer tissues. The paper reports expression validation and correlation with circPDIA4, but does not report individual functional assays for this circRNA."	0.4685
36562654	Cancer research	2023	CircPDIA4 Induces Gastric Cancer Progression by Promoting ERK1/2 Activation and Enhancing Biogenesis of Oncogenic circRNAs.	hsa_circ_0003179	circ_0003179			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"circ_0003179 is one of the circPDIA4-induced candidate oncogenic circRNAs and is up-regulated in gastric cancer tissues. The paper reports expression validation and correlation with circPDIA4, but does not report individual functional assays for this circRNA."	0.4685
36564929	Journal of biochemical and molecular toxicology	2023	Circular RNA expression profile identifies circMGEA5 as a novel metastasis-promoting factor and potential biomarker in osteosarcoma.	hsa_circ_0019606	circMGEA5	hsa_circ_MGEA5	MGEA5	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; ISH; Microarray	"circMGEA5 is up-regulated in metastatic osteosarcoma tissues and high expression predicts poor overall and disease-free survival. It promotes OS migration, invasion, EMT, and lung metastasis by sponging miR-153-3p and miR-8084 to increase ZEB1 and Snail, while ZEB1 and Snail transcriptionally activate circMGEA5 to form a positive feedback loop."	0.8633
36572073	Gene	2023	Hsa_circ_0020378 targets miR-556-5p/MAPK1 to regulate osteosarcoma cell proliferation and migration.	hsa_circ_0020378	circ_0020378			osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circ_0020378 is up-regulated in osteosarcoma tissues and cells and functions as an oncogenic circRNA. It promotes OS cell proliferation, colony formation, migration, and xenograft tumor growth by sponging miR-556-5p and relieving miR-556-5p-mediated repression of MAPK1."	0.7799
36574090	Apoptosis : an international journal on programmed cell death	2023	"circTAB2 inhibits lung cancer proliferation, migration and invasion by sponging miR-3142 to upregulate GLIS2."	hsa_circ_0078200	circTAB2	hsa_circ_TAB2	TAB2	lung cancer	MONDO:0008903	lung cancer	down-regulated	RT-qPCR; Microarray	"circTAB2 is downregulated in lung cancer and mainly localizes to the cytoplasm. It suppresses proliferation, migration, and invasion while promoting apoptosis by acting as a ceRNA sponge for miR-3142, thereby upregulating GLIS2 and inhibiting AKT signaling."	0.8375
36576137	Animal biotechnology	2023	High-throughput analysis of CircRNA in cows with naturally infected Staphylococcus aureus mammary gland.		circRNA2860	bta_circ_TRPS1	TRPS1	bovine mastitis	MONDO:0025100	"mastitis, bovine"	up-regulated	RT-qPCR; RNA-seq	circRNA2860 was identified as an up-regulated circRNA in Staphylococcus aureus-associated cow mastitis and was validated by qPCR. The study suggests that circRNA2860 and its host gene TRPS1 may play important regulatory roles in cow mastitis.	0.4761
36576137	Animal biotechnology	2023	High-throughput analysis of CircRNA in cows with naturally infected Staphylococcus aureus mammary gland.		circRNA5323	bta_circ_SLC12A2	SLC12A2	bovine mastitis	MONDO:0025100	"mastitis, bovine"	dysregulated	RT-qPCR; RNA-seq	circRNA5323 was validated as significantly differentially expressed in cow mastitis by RNA-seq and qPCR. The study predicts that circRNA5323 interacts with multiple miRNAs and suggests that its host gene SLC12A2 may affect cow mastitis through the salivary secretion pathway.	0.4761
36576137	Animal biotechnology	2023	High-throughput analysis of CircRNA in cows with naturally infected Staphylococcus aureus mammary gland.		circRNA4027	bta_circ_MYH11	MYH11	bovine mastitis	MONDO:0025100	"mastitis, bovine"	down-regulated	RT-qPCR; RNA-seq	circRNA4027 was identified as a down-regulated circRNA in cow mastitis and validated by qPCR. The study predicts that circRNA4027 may sponge several miRNAs and suggests that its host gene MYH11 is involved in tight junction-related regulation of mastitis.	0.4761
36576137	Animal biotechnology	2023	High-throughput analysis of CircRNA in cows with naturally infected Staphylococcus aureus mammary gland.		circRNA2584	bta_circ_TEAD1	TEAD1	bovine mastitis	MONDO:0025100	"mastitis, bovine"	dysregulated	RNA-seq	circRNA2584 was reported as a differentially expressed circRNA in cow mastitis based on RNA-seq and functional enrichment analysis. The study links circRNA2584 and its host gene TEAD1 to transcription-related and adherens junction biological processes in mastitis.	0.1768
36576137	Animal biotechnology	2023	High-throughput analysis of CircRNA in cows with naturally infected Staphylococcus aureus mammary gland.		circRNA4513	bta_circ_CREBRF	CREBRF	bovine mastitis	MONDO:0025100	"mastitis, bovine"	dysregulated	RNA-seq	circRNA4513 was reported as a differentially expressed circRNA in cow mastitis based on RNA-seq and enrichment analysis. The study associates circRNA4513 and host gene CREBRF with transcription-related and adherens junction biological processes.	0.1768
36576137	Animal biotechnology	2023	High-throughput analysis of CircRNA in cows with naturally infected Staphylococcus aureus mammary gland.		circRNA8726	bta_circ_AFDN	AFDN	bovine mastitis	MONDO:0025100	"mastitis, bovine"	dysregulated	RNA-seq	circRNA8726 was reported as a differentially expressed circRNA in cow mastitis based on RNA-seq and functional enrichment analysis. The study associates circRNA8726 with host gene AFDN and tight junction-related regulation.	0.1768
36576137	Animal biotechnology	2023	High-throughput analysis of CircRNA in cows with naturally infected Staphylococcus aureus mammary gland.		circRNA1119			bovine mastitis	MONDO:0025100	"mastitis, bovine"	dysregulated	RNA-seq	circRNA1119 was reported as a differentially expressed circRNA in cow mastitis. The study suggests that its host gene ENSBTAG00000010619 is located in the MAPK signaling pathway and may contribute to mastitis regulation.	0.1768
36576783	Cancer biotherapy & radiopharmaceuticals	2024	Circ-PGAM1 Enhances Matrine Resistance of Non-Small Cell Lung Cancer via the miR-326/CXCR5 Axis.	hsa_circ_0019340	circular-phosphoglycerate mutase 1 / circ-PGAM1	hsa_circ_PGAM1	PGAM1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circ-PGAM1 is up-regulated in NSCLC cell lines and TCGA lung adenocarcinoma tumor samples. Functionally, circ-PGAM1 enhances resistance of NSCLC cells to matrine by promoting colony formation and inhibiting apoptosis under matrine treatment. Mechanistically, the study implicates a circ-PGAM1/miR-326/CXCR5 regulatory axis, and high circ-PGAM1 expression is associated with poor overall survival."	0.5546
36580535	DNA and cell biology	2023	Circ_0001060 Upregulates and Encourages Progression in Osteosarcoma.	hsa_circ_0001060	circ_0001060	hsa_circ_UXS1	UXS1	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; RNA-seq	"circ_0001060 is up-regulated in osteosarcoma and high expression is associated with metastasis, larger tumor size, poor overall survival, and diagnostic potential. Functionally, circ_0001060 promotes OS cell proliferation, migration, invasion, and cell cycle progression while suppressing apoptosis. Mechanistically, it is mainly cytoplasmic and may function as a miRNA sponge within circRNA-miRNA-mRNA axes involving miR-203a-5p/TRIM21, miR-208b-5p/MAP3K5, and miR-203a-5p/PRKX."	0.8308
36581129	Genomics	2023	Hsa_circ_0049396 inhibited oral squamous cell carcinoma progression by regulating the miR-663b/ENDOU axis.	hsa_circ_0049396	circ_102450			oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR	"circ_0049396 is downregulated in OSCC tissues and cells and functions as a tumor suppressor. Its overexpression inhibits proliferation, migration, and xenograft tumor growth while promoting apoptosis through the miR-663b/ENDOU ceRNA axis, suggesting therapeutic and biomarker potential."	0.7968
36581129	Genomics	2023	Hsa_circ_0049396 inhibited oral squamous cell carcinoma progression by regulating the miR-663b/ENDOU axis.	hsa_circ_0096042	circRNA_100834			oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR	"circRNA_100834, identified as hsa_circ_0096042, was one of two circBase-listed downregulated circRNAs explored in OSCC tissues. The study validated its decreased expression in clinical OSCC tissues by RT-qPCR but did not further investigate its function or mechanism."	0.348
36583788	Biochemical genetics	2023	Circ_0006646 Accelerates the Growth and Metastasis of Cervical Cancer by Elevating RRM2 Through miR-758-3p.	hsa_circ_0006646	circ_0006646	hsa_circ_PTK2	PTK2	Cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ_0006646 is up-regulated in cervical cancer cells and in plasma exosomes from cervical cancer patients. It promotes cervical cancer growth, proliferation, migration, invasion, EMT, metastasis and in vivo tumor growth by sponging miR-758-3p and increasing RRM2 expression. Exosomal circ_0006646 showed diagnostic potential for distinguishing cervical cancer patients from healthy controls."	0.8146
36585543	Neurotoxicity research	2023	CircUBE3B High Expression Participates in Sevoflurane-Induced Human Hippocampal Neuron Injury via Targeting miR-326 and Regulating MYD88 Expression.	hsa_circ_0028135	circRNA UBE3B	hsa_circ_UBE3B	UBE3B	postoperative cognitive dysfunction / POCD	MONDO:0002602	central nervous system disorder	up-regulated	RT-qPCR	"CircUBE3B is up-regulated in Sevo-treated human hippocampal neurons and contributes to Sevo-induced neuronal injury. Mechanistically, circUBE3B sponges miR-326 and positively regulates MYD88, thereby promoting apoptosis and inflammatory responses while reducing cell viability."	0.6253
36585554	Cardiovascular drugs and therapy	2024	Circ_0026218 ameliorates oxidized low-density lipoprotein-induced vascular endothelial cell dysfunction by regulating miR-188-3p/TLR4/NF-kappaB pathway.	hsa_circ_0026218	circ_0026218	hsa_circ_CERS5	CERS5	atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"circ_0026218 is up-regulated in AS patient serum and ox-LDL-induced HUVECs. It aggravates endothelial cell dysfunction by sponging miR-188-3p to regulate TLR4 and activate the NF-kappaB pathway, thereby affecting proliferation, apoptosis, inflammation, and oxidative stress. Exosomal circ_0026218 may serve as a diagnostic indicator for AS."	0.8322
36592530	International immunopharmacology	2023	CircVAPA contributes to hyper-proliferation and inflammation of keratinocytes through miR-125b-5p/sirt6 axis in psoriasis.		circVAPA	hsa_circ_VAPA	VAPA	psoriasis	MONDO:0005083	psoriasis	up-regulated	RT-qPCR	"circVAPA is up-regulated in psoriatic lesional skin and M5-stimulated HaCaT keratinocytes. It promotes keratinocyte proliferation and inflammatory cytokine production while suppressing apoptosis, acting through a ceRNA mechanism in which it sponges miR-125b-5p to increase Sirt6 expression. The study suggests circVAPA as a potential therapeutic target for psoriasis."	0.8119
36594718	Histology and histopathology	2023	Matrine inhibits hepatocellular carcinoma cell malignancy through the circ_0013290/miR-139-5p/MMP16 pathway.	hsa_circ_0013290	circ_0013290			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0013290 is up-regulated in HCC tissues and cell lines and functions as a cancer-promoting circRNA. It sponges miR-139-5p to increase MMP16 expression, thereby promoting HCC cell proliferation, invasion, tube formation and tumorigenesis while suppressing apoptosis. Matrine exerts anti-HCC effects by downregulating circ_0013290 and modulating the circ_0013290/miR-139-5p/MMP16 pathway."	0.8006
36596968	Molecular neurobiology	2023	Co-Administration of Vitamins B12 and D During Pregnancy Have Strong Neuroprotective Effects in Parkinson Disease.	mmu_circ_0001518	"circRNA 0,001,518"			Parkinson's disease / PD	MONDO:0005180	Parkinson disease	up-regulated	RT-qPCR	"In this rotenone-induced mouse model of Parkinson's disease, circRNA 0,001,518 was significantly overexpressed in cerebellar/cerebral neurons of PD female mice, while no significant expression difference was observed in fetuses derived from PD females. Vitamin B12 and vitamin D treatment reduced circRNA 0,001,518 expression, and the authors suggest that its overexpression may be related to neuronal death under PD conditions."	0.2586
36597773	"Shock (Augusta, Ga.)"	2023	CIRC_0114428 INFLUENCES THE PROGRESSION OF SEPTIC ACUTE KIDNEY INJURY VIA REGULATING MIR-370-3P/TIMP2 AXIS.	hsa_circ_0114428	circ_0114428	hsa_circ_ZNF644	ZNF644	septic acute kidney injury	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR	"Circ_0114428 is up-regulated in septic AKI patient serum and LPS-induced HK2 cells. It promotes septic AKI-related cellular injury by sponging miR-370-3p and increasing TIMP2 expression, leading to reduced proliferation, cell cycle arrest, increased inflammatory cytokine secretion, and apoptosis. The study suggests circ_0114428 may be a potential diagnostic and therapeutic target for septic AKI."	0.8119
36598315	Bratislavske lekarske listy	2023	"Hsa_circ_0097009 regulates proliferation, apoptosis, migration and invasion of hepatocellular carcinoma cells via miR-568/RNF38 axis."	hsa_circ_0097009	circ_0097009			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"Hsa_circ_0097009/circ_0097009 is up-regulated in HCC tissues and cells and functions as an oncogenic circRNA. Its knockdown suppresses HCC cell proliferation, colony formation, migration, invasion, angiogenesis and xenograft tumor growth while promoting apoptosis. Mechanistically, circ_0097009 sponges miR-568 to up-regulate RNF38, forming a circ_0097009/miR-568/RNF38 regulatory axis with potential therapeutic relevance."	0.8006
36598578	Journal of cancer research and clinical oncology	2023	Suppression of exosomal hsa_circ_0001005 eliminates the Vemurafenib resistance of melanoma.	hsa_circ_0001005	circ_0001005	hsa_circ_ASB3	ASB3	melanoma	MONDO:0005105	melanoma	up-regulated	RT-qPCR; Microarray	"This study identifies exosomal hsa_circ_0001005 as an up-regulated circRNA in Vemurafenib-resistant melanoma cells and exosomes. It promotes drug resistance and proliferation through a ceRNA/miRNA sponge mechanism affecting downstream genes and resistance-related pathways, and its suppression restores Vemurafenib sensitivity in vitro and in a xenograft model. Elevated hsa_circ_0001005 is associated with poor prognosis and may represent a therapeutic target or drug-resistance biomarker."	0.7477
36598961	Journal of pediatric hematology/oncology	2023	Identification of Circular RNA Circ_0003256 as a Novel Player in Pediatric Acute Myeloid Leukemia.	hsa_circ_0003256	circ_0003256	hsa_circ_CIT	CIT	pediatric acute myeloid leukemia / pediatric AML	MONDO:0004996	childhood acute myeloid leukemia	up-regulated	RT-qPCR	"circ_0003256 is up-regulated in bone marrow samples from pediatric AML patients and in AML cell lines. Functionally, circ_0003256 supports malignant AML cell behaviors by promoting proliferation and cell cycle progression while inhibiting apoptosis. Mechanistically, it acts through a ceRNA-like circ_0003256/miR-582-3p/PRKACB axis, and its up-regulation may have potential diagnostic value in pediatric AML."	0.7591
36600025	Human cell	2023	"METTL3-mediated Hsa_circ_0000390 downregulation enhances the proliferation, migration, and invasion of colorectal cancer cells by increasing Notch1 expression."	hsa_circ_0000390	Circ_0000390	hsa_circ_FGD4	FGD4	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"hsa_circ_0000390 is downregulated in colorectal cancer tissues and functions as a tumor-suppressive circRNA. Its overexpression inhibits CRC cell proliferation, migration, invasion, EMT-related changes, and xenograft tumor growth, at least partly by reducing Notch1/Hes1 signaling; METTL3-mediated downregulation of circ_0000390 promotes malignant CRC phenotypes."	0.6285
36600625	Protein and peptide letters	2023	Circ_0002762 Regulates Oncoprotein YBX1 in Cervical Cancer via mir-375 to Regulate the Malignancy of Cancer Cells.	hsa_circ_0002762	circ_0002762			cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ_0002762 is up-regulated in cervical carcinoma tissues and cell lines and is associated with larger tumor size and lymph node metastasis. Functionally, circ_0002762 promotes cervical cancer cell proliferation, migration, and pulmonary metastasis. Mechanistically, it acts as a cytoplasmic ceRNA that sponges miR-375 to increase YBX1 mRNA and protein expression."	0.73
36602424	Anti-cancer drugs	2023	CircRNA B cell linker regulates cisplatin sensitivity in nonsmall cell lung cancer via microRNA-25-3p/BarH_like homeobox 2 axis.		circRNA B cell linker / circ_BLNK	hsa_circ_BLNK	BLNK	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"This study identifies circ_BLNK as a down-regulated circRNA in cisplatin-resistant NSCLC cells and tumor-resistant NSCLC tissues. Functionally, circ_BLNK overexpression increases cisplatin sensitivity, promotes apoptosis, inhibits malignant phenotypes, and suppresses xenograft tumor development. Mechanistically, circ_BLNK acts through the miR-25-3p/BARX2 axis."	0.7859
36604405	Journal of endocrinological investigation	2023	Circ_0124055 promotes the progression of thyroid cancer cells through the miR-486-3p/MTA1 axis.	hsa_circ_0124055	circ_0124055 / circDAG1	hsa_circ_DAG1	DAG1	thyroid cancer / TC	MONDO:0002108	thyroid cancer	up-regulated	RT-qPCR	"Circ_0124055 is up-regulated in thyroid cancer tissues and cells. It promotes thyroid cancer progression by sponging miR-486-3p and regulating MTA1 expression, thereby enhancing proliferation, migration, invasion, EMT-related changes and in vivo tumor growth while suppressing apoptosis."	0.8175
36607259	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2023	CircAGK regulates high dihydrotestosterone-induced apoptosis in DPCs through the miR-3180-5p/BAX axis.	hsa_circ_0002980	circAGK	hsa_circ_AGK	AGK	androgen alopecia	MONDO:0005339	androgenetic alopecia	up-regulated	RT-qPCR; RNA-seq	"This study identifies hsa_circ_0002980/circAGK as an up-regulated circRNA in hair follicles from AGA patients. circAGK is a cytoplasmic circular RNA derived from AGK and promotes DHT-induced DPC apoptosis by regulating the miR-3180-5p/BAX axis. In vivo, circAGK overexpression inhibits hair growth in an AGA mouse model, suggesting therapeutic relevance for AGA."	0.8107
36607937	Pancreas	2022	Circular RNA Fibroblast Growth Factor Receptor 1 Promotes Pancreatic Cancer Progression by Targeting MicroRNA-532-3p/PIK3CB Axis.	hsa_circ_0084003	circFGFR1	hsa_circ_FGFR1	FGFR1	pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR; ISH	"circFGFR1 is up-regulated in PDAC tissues and cell lines, and high expression is associated with lymph-node metastasis, higher TNM stage, and poorer survival. Functionally, circFGFR1 promotes PDAC proliferation, migration, invasion, tumor growth, and lung metastasis while inhibiting apoptosis. Mechanistically, cytoplasmic circFGFR1 sponges miR-532-3p to increase PIK3CB expression and activate PI3K-related malignant processes."	0.8498
36608057	Head & neck	2023	Association of genetic variants of CircCHST15 with oral squamous cell carcinoma in the Chinese Han population.	hsa_circ_0000264	CircCHST15	hsa_circ_CHST15	CHST15	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RNA-seq	This study found that circCHST15 is upregulated in OSCC tissues and that genetic variants in the circCHST15 region are associated with OSCC susceptibility. The rs28707473 A > C variant may increase circCHST15 expression by altering RNA structure and enhancing TCF4-related transcriptional regulation of CHST15/circCHST15.	0.6303
36608447	International immunopharmacology	2023	Circ_0001721 knockdown relieves IL-1beta-induced chondrocyte injury via regulating miR-373-3p/CXCR4 in osteoarthritis.	hsa_circ_0001721	circ_0001721	hsa_circ_CDK14	CDK14	osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"In this study, circ_0001721 was up-regulated in cartilage tissues from OA patients and in IL-1beta-induced human chondrocytes. Functional experiments showed that circ_0001721 knockdown relieved IL-1beta-induced chondrocyte injury by promoting proliferation and reducing apoptosis, ECM degradation and inflammation. Mechanistically, circ_0001721 acted as a sponge for miR-373-3p to upregulate CXCR4, supporting its potential as a therapeutic target for OA."	0.8417
36608833	Transplant immunology	2023	Depletion of circ_0006459 protects human brain microvascular endothelial cells from oxygen-glucose deprivation-induced damage through the miR-940/FOXJ2 pathway.	hsa_circ_0006459	circ_0006459	hsa_circ_GNAQ	GNAQ	ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR	"Circ_0006459 is up-regulated in OGD-treated human brain microvascular endothelial cells, an in vitro ischemic stroke model. Its knockdown protects against OGD-induced injury by enhancing proliferation and reducing apoptosis and inflammation. Mechanistically, circ_0006459 sponges miR-940 to increase FOXJ2 expression."	0.7609
36609531	"Shock (Augusta, Ga.)"	2023	CircNRIP1 KNOCKDOWN ALLEVIATES LIPOPOLYSACCHARIDE-INDUCED HUMAN KIDNEY 2 CELL APOPTOSIS AND INFLAMMATION THROUGH miR-339-5p/OXSR1 PATHWAY.	hsa_circ_0001177	circNRIP1 / circ_0001177	hsa_circ_NRIP1	NRIP1	septic acute kidney injury	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR	"CircNRIP1 is up-regulated in blood from septic AKI patients and in LPS-induced HK2 cells. The study shows that circNRIP1 knockdown protects HK2 cells from LPS-induced injury by reducing apoptosis and inflammatory cytokine production, mechanistically through the miR-339-5p/OXSR1 axis."	0.7968
36610331	International immunopharmacology	2023	Circular RNA_0003800 exacerbates IL-1beta-induced chondrocyte injury via miR-197-3p/SOX5 axis.	hsa_circ_0003800	Circular RNA_0003800			Osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circ_0003800 is up-regulated in OA tissues and IL-1beta-induced human chondrocyte models. It exacerbates OA-related chondrocyte injury by sponging miR-197-3p and positively regulating SOX5, leading to increased apoptosis, ECM degradation, inflammatory response and oxidative stress, while suppressing proliferation."	0.8115
36610987	Toxicological sciences : an official journal of the Society of Toxicology	2023	Circ_0089282 inhibits carbon black nanoparticle-induced DNA damage by promoting DNA repair protein in the lung.	hsa_circ_0089282	circ_0089282	hsa_circ_SETX	SETX	CBNP-induced DNA damage in the lung	MONDO:0000001	disease	up-regulated	RT-qPCR; RNA-seq	"circ_0089282 is up-regulated after CBNP exposure in human bronchial epithelial cells and mouse lung. It suppresses CBNP-induced DNA damage by binding FUS and positively regulating the DNA repair protein LIG4, thereby promoting DNA repair, likely through the NHEJ repair process."	0.7529
36617218	Journal of applied toxicology : JAT	2023	Circ_0027470 promotes cadmium exposure-induced prostatic fibrosis via sponging miRNA-1236-3p and stimulating SHH signaling pathway.	hsa_circ_0027470	circ_0027470			benign prostatic hyperplasia / BPH	MONDO:0010811	benign prostatic hyperplasia	up-regulated	RT-qPCR	"Cd exposure up-regulates circ_0027470 in prostate-related experimental models. circ_0027470 promotes Cd exposure-induced prostatic fibrosis by sponging miRNA-1236-3p, which increases SHH signaling activity and promotes EMT and primary ciliogenesis."	0.6207
36617218	Journal of applied toxicology : JAT	2023	Circ_0027470 promotes cadmium exposure-induced prostatic fibrosis via sponging miRNA-1236-3p and stimulating SHH signaling pathway.		circ_0027470			benign prostatic hyperplasia / BPH	MONDO:0010811	benign prostatic hyperplasia	up-regulated	RT-qPCR	"Cd exposure up-regulates circ_0027470 in prostate-related experimental models. circ_0027470 promotes Cd exposure-induced prostatic fibrosis by sponging miRNA-1236-3p, which increases SHH signaling activity and promotes EMT and primary ciliogenesis."	0.6207
36617513	"Nucleosides, nucleotides & nucleic acids"	2023	Has_circ_0048764 promotes breast cancer progression by sponging miR-578 and regulating HMGA2 expression.	hsa_circ_0048764	circ_0048764			breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circ_0048764 is up-regulated in breast cancer tissues and cell lines and is associated with more aggressive clinicopathological features. Functionally, it promotes BC cell growth, migration and invasion. Mechanistically, circ_0048764 sponges miR-578 to relieve repression of HMGA2, forming a circ_0048764/miR-578/HMGA2 regulatory axis."	0.7858
36617735	"Cell cycle (Georgetown, Tex.)"	2023	CircHGS enhances the progression of bladder cancer by regulating the miR-513a-5p/VEGFC axis and activating the AKT/mTOR signaling pathway.	hsa_circ_0004721	circHGS	hsa_circ_HGS	HGS	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"circHGS (hsa_circ_0004721), derived from HGS, is upregulated in bladder cancer tissues and cells and correlates positively with tumor grade and pathological T stage. It promotes BCa proliferation, cell cycle progression, migration, invasion and xenograft tumor growth by sponging miR-513a-5p, increasing VEGFC expression, and activating AKT/mTOR signaling."	0.7536
36623264	Molecular reproduction and development	2023	Circular RNA SESN2 aggravates gestational trophoblast cell damage induced by high glucose by binding to IGF2BP2.		circSESN2 / circRNA sestrin 2	hsa_circ_SESN2	SESN2	gestational diabetes mellitus / GDM	MONDO:0005406	gestational diabetes	up-regulated	RT-qPCR; Microarray	"circSESN2 is up-regulated in placental tissues and peripheral blood from GDM patients and in high glucose-treated HTR-8/SVneo trophoblast cells. Functionally, circSESN2 aggravates high glucose-induced trophoblast cell injury by promoting apoptosis, inflammation and oxidative stress while suppressing viability, migration and invasion. Mechanistically, circSESN2 binds IGF2BP2 and enhances IGF2BP2 protein expression."	0.7598
36626032	Human cell	2023	CircMAN1A2 contributes to nasopharyngeal carcinoma progression via enhancing the ubiquitination of ATMIN through miR-135a-3p/UBR5 axis.		circMAN1A2	hsa_circ_MAN1A2	MAN1A2	nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; Northern Blot	"circMAN1A2 is up-regulated in NPC tissues and cells and its high expression is associated with shorter OS, DFS, and DMFS. Functionally, circMAN1A2 promotes NPC proliferation, migration, invasion, EMT, tumor growth, and metastasis. Mechanistically, cytoplasmic circMAN1A2 sponges miR-135a-3p to increase UBR5 expression, leading to UBR5-mediated ubiquitination of ATMIN."	0.8637
36627006	Cellular signalling	2023	Increased transcription of hsa_circ_0000644 upon RUNX family transcription factor 3 downregulation participates in the malignant development of bladder cancer.	hsa_circ_0000644	circ_644 / hsa_circ_001067	hsa_circ_KIAA1199	KIAA1199	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000644 (circ_644) is up-regulated in bladder cancer tissues and cell lines and is associated with higher T stage and advanced tumor grade. RUNX3 downregulation increases circ_644 transcription, while circ_644 promotes BCa proliferation, migration, invasion, cell cycle progression, and xenograft tumor growth by sponging miR-143-3p and upregulating MSI2 mRNA."	0.8035
36627545	Human cell	2023	Circular RNA hsa_circ_0000519 contributes to angiogenesis and tumor progression in hepatocellular carcinoma through the miR-1296/E2F7 axis.	hsa_circ_0000519	hsa_cir-cRPPH1_010 / circ_0000519	hsa_circ_RPPH1	RPPH1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"hsa_circ_0000519 is up-regulated in HCC tissues and cell lines and its high expression is associated with poor prognosis and adverse clinicopathological features. Functionally, it promotes HCC cell proliferation, cell cycle progression, migration, invasion, angiogenesis, tumor growth, and metastasis. Mechanistically, hsa_circ_0000519 sponges miR-1296 to up-regulate E2F7, forming a hsa_circ_0000519/miR-1296/E2F7 axis with potential therapeutic relevance."	0.8498
36628205	American journal of translational research	2022	Circular RNA FOXO3 regulates endometrial carcinoma progression through the microRNA-29a-3p/HDAC4 axis.	hsa_circ_0006404	circular RNA FOXO3	hsa_circ_FOXO3	FOXO3	endometrial cancer / EC	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR	"circ_FOXO3 is up-regulated in human endometrial carcinoma tissues and cell lines and is associated with poor overall survival and aggressive clinicopathological features. Functionally, circ_FOXO3 promotes EC proliferation, migration, invasion, cell-cycle progression, and xenograft tumor growth while suppressing apoptosis. Mechanistically, it acts as a miR-29a-3p sponge to increase HDAC4 expression through the circ_FOXO3/miR-29a-3p/HDAC4 axis."	0.7412
36628810	Clinical breast cancer	2023	Hsa_circ_0008673 Promotes Breast Cancer Progression by MiR-578/GINS4 Axis.	hsa_circ_0008673	circ_0008673			breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"Hsa_circ_0008673 is up-regulated in breast cancer tissues and cell lines. It functions as an oncogenic circRNA by sponging miR-578 to increase GINS4 expression, thereby promoting breast cancer cell proliferation, migration, invasion, angiogenesis and xenograft tumor growth while suppressing apoptosis. The hsa_circ_0008673/miR-578/GINS4 axis is proposed as a potential therapeutic target for breast cancer."	0.8005
36629013	Histology and histopathology	2023	Circ-0000979 promotes the development of gastric carcinoma by sponging miR-136 and modulating SP1 mRNA expression level.	hsa_circ_0000979	hsa_circRNA_001587 / circRNA0000979			gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circ-0000979 is up-regulated in gastric cancer tissues and cell lines, and high expression is associated with poorer prognosis and clinicopathological progression. Mechanistically, cytoplasmic circ-0000979 promotes GC proliferation, migration, invasion/metastasis and xenograft tumor growth by sponging miR-136 and regulating SP1 mRNA/protein expression."	0.8554
36633773	Biochemical genetics	2023	Circ_0060937 Contributes to the Development of Lung Cancer via Positively Regulating LAD1 Expression by Binding to miR-1304-5p.	hsa_circ_0060937	Circ_0060937	hsa_circ_CYP24A1	CYP24A1	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR	"Circ_0060937 is up-regulated in lung cancer tissues and A549/H1299 lung cancer cells. It acts as an oncogenic circRNA that promotes proliferation, migration, invasion, sphere formation, cell cycle progression, and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ_0060937 binds miR-1304-5p and relieves miR-1304-5p-mediated repression of LAD1, thereby activating the circ_0060937/miR-1304-5p/LAD1 regulatory axis."	0.7554
36633774	Biochemical genetics	2023	"Circ_0001821 Potentiates Cell Growth, Metastasis, and Stemness in Colorectal Cancer by Regulating miR-339-3p/CST1."	hsa_circ_0001821	circ_0001821	hsa_circ_PVT1	PVT1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0001821 is up-regulated in colorectal cancer tissues and cells and mainly localizes in the cytoplasm. It promotes CRC proliferation, migration, invasion, EMT, stemness, and xenograft tumor growth by sponging miR-339-3p and regulating CST1 expression, suggesting potential therapeutic relevance."	0.7855
36635223	Experimental dermatology	2023	Circ_0001402 knockdown suppresses the chemoresistance and development of DDP-resistant cutaneous squamous cell carcinoma cells by functioning as a ceRNA for miR-625-5p.	hsa_circ_0001402	hsa_circRNA_103621 / circ_0001402	hsa_circ_TBC1D1	TBC1D1	cutaneous squamous cell carcinoma / CSCC	MONDO:0002529	skin squamous cell carcinoma	up-regulated	RT-qPCR	"In this study, circ_0001402 was identified as an up-regulated circRNA in CSCC tissues, CSCC cell lines, and especially DDP-resistant CSCC samples. Functionally, circ_0001402 promotes malignant behaviors and cisplatin resistance, while its knockdown induces apoptosis and suppresses colony formation, migration, invasion, tumor growth, and MDR marker expression. Mechanistically, circ_0001402 acts as a ceRNA for miR-625-5p to enhance KPNA4 expression, forming a circ_0001402/miR-625-5p/KPNA4 axis."	0.7949
36635458	Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico	2023	CircZNF236 facilitates malignant progression in oral squamous cell carcinoma by sequestering miR-145-5p.		circZNF236	hsa_circ_ZNF236	ZNF236	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circZNF236 is upregulated in OSCC tissues and cell lines, and high expression is associated with poor patient survival. Functionally, circZNF236 promotes OSCC cell proliferation, migration, invasion and xenograft tumor growth while suppressing apoptosis. Mechanistically, it acts as a ceRNA sponge for miR-145-5p to increase MBTD1 expression, thereby facilitating OSCC progression."	0.8632
36635928	Current molecular pharmacology	2023	Guggulsterone Promotes Nasopharyngeal Carcinoma Cells Exosomal Circfip1L1 to Mediate miR-125a-5p/VEGFA Affecting Tumor Angiogenesis.		circFIP1L1	hsa_circ_FIP1L1	FIP1L1	Nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	unknown	RT-qPCR	"This study investigated exosomal circFIP1L1 in nasopharyngeal carcinoma cells under guggulsterone treatment. GS promoted secretion of exosomal circFIP1L1 from HNE1 cells, and exosomal circFIP1L1 sponged miR-125a-5p to repress VEGFA-related signaling, thereby inhibiting HUVEC proliferation and angiogenesis. The authors propose this circFIP1L1-mediated axis as a potential therapeutic target for NPC."	0.4546
36637163	Environmental toxicology	2023	Circ-N4BP2L2 enhances mitochondrial function in non-small cell lung cancer cells through regulating the miR-135a-5p/ARL5B axis.		circRNA NEDD4 binding protein 2 like 2 / circ-N4BP2L2	hsa_circ_N4BP2L2		non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ-N4BP2L2 is up-regulated in NSCLC tissues and cell lines, and high expression is associated with advanced clinical stage, lymph node metastasis, and poor prognosis. Functionally, it promotes NSCLC proliferation, invasion, mitochondrial function, and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ-N4BP2L2 sponges miR-135a-5p to increase ARL5B expression, forming a circ-N4BP2L2/miR-135a-5p/ARL5B ceRNA axis."	0.8148
36637791	Neuroscience bulletin	2023	CircFhit Modulates GABAergic Synaptic Transmission via Regulating the Parental Gene Fhit Expression in the Spinal Dorsal Horn in a Rat Model of Neuropathic Pain.		circFhit	rno_circ_Fhit	Fhit	neuropathic pain	MONDO:0021667	neuralgia	up-regulated	RT-qPCR; RNA-seq	"CircFhit is an exon-intron circRNA derived from Fhit and upregulated in the spinal dorsal horn after spared nerve injury in rats. It promotes neuropathic pain by increasing parental Fhit transcription through a circFhit/HNRNPK-CDK9/RNF40 mechanism, reducing GAD65-mediated GABAergic inhibitory transmission and enhancing NK1R+ neuronal excitability."	0.8416
36645554	Biochemical genetics	2023	Evaluation of Circ_0000977-Mediated Regulatory Network in Breast Cancer: A Potential Discriminative Biomarker for Triple-Negative Tumors.	hsa_circ_0000977	Circ_0000977	hsa_circ_NOL10	NOL10	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	"This study identified circ_0000977/hsa_circ_0000977 as a down-regulated circRNA in TNBC compared with non-TNBC tumors and validated this pattern in tumor tissues, cell lines, and plasma. The authors propose that circ_0000977 participates in a ceRNA network by interacting with miR-135b-5p and regulating downstream tumor-suppressor mRNAs, especially APC and GATA3. Clinically, plasma circ_0000977 showed diagnostic potential for TNBC, and lower tumor expression was associated with shorter disease-free survival."	0.7513
36645579	Molecular biotechnology	2023	Hsa_circ_0000078 Regulates miR-205-5p/EREG Pathway to Inhibit Cervical Cancer Progression.	hsa_circ_0000078	circ_0000078	hsa_circ_USP1	USP1	cervical cancer / CC	MONDO:0002974	cervical cancer	down-regulated	RT-qPCR	"Hsa_circ_0000078/circ_0000078 is downregulated in cervical cancer tissues and cell lines. It acts as a tumor suppressor by inhibiting proliferation, migration, invasion, and xenograft tumor growth while promoting apoptotic activity, mainly through regulation of the miR-205-5p/EREG axis."	0.7795
36646008	Ecotoxicology and environmental safety	2023	Human umbilical cord mesenchymal stem cell-derived extracellular vesicles alleviated silica induced lung inflammation and fibrosis in mice via circPWWP2A/miR-223-3p/NLRP3 axis.		circular RNA PWWP2A / circPWWP2A	mmu_circ_PWWP2A	PWWP2A	silicosis	MONDO:0005960	silicosis	up-regulated	RT-qPCR	"circPWWP2A is up-regulated after silica exposure in mouse lung tissue and RAW264.7 macrophages. It acts as a miR-223-3p sponge, relieving miR-223-3p-mediated repression of NLRP3 and thereby promoting NLRP3 activation, inflammatory cytokine production, fibroblast activation, collagen deposition, and silica-induced pulmonary fibrosis. hucMSC-EVs deliver miR-223-3p to suppress circPWWP2A and attenuate lung inflammation and fibrosis through the circPWWP2A/miR-223-3p/NLRP3 axis."	0.6579
36646968	Molecular neurobiology	2023	CircLPAR1 Promotes Neuroinflammation and Oxidative Stress in APP/PS1 Mice by Inhibiting SIRT1/Nrf-2/HO-1 Axis Through Destabilizing GDF-15 mRNA.		circLPAR1 / CircRNA lysophosphatidic acid receptor 1	hsa_circ_LPAR1	LPAR1	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR	"circLPAR1 is up-regulated in APP/PS1 mouse brain and Abeta-treated SH-SY5Y cells. It promotes AD-like neuronal injury, neuroinflammation, oxidative stress, and apoptosis by recruiting UPF1 to destabilize GDF-15 mRNA, suppressing the GDF-15/SIRT1/Nrf-2/HO-1 protective axis. Silencing circLPAR1 alleviates cellular injury and improves cognitive/pathological phenotypes in APP/PS1 mice."	0.6966
36646968	Molecular neurobiology	2023	CircLPAR1 Promotes Neuroinflammation and Oxidative Stress in APP/PS1 Mice by Inhibiting SIRT1/Nrf-2/HO-1 Axis Through Destabilizing GDF-15 mRNA.		circLPAR1 / CircRNA lysophosphatidic acid receptor 1	mmu_circ_LPAR1	LPAR1	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	up-regulated	RT-qPCR	"circLPAR1 is up-regulated in APP/PS1 mouse brain and Abeta-treated SH-SY5Y cells. It promotes AD-like neuronal injury, neuroinflammation, oxidative stress, and apoptosis by recruiting UPF1 to destabilize GDF-15 mRNA, suppressing the GDF-15/SIRT1/Nrf-2/HO-1 protective axis. Silencing circLPAR1 alleviates cellular injury and improves cognitive/pathological phenotypes in APP/PS1 mice."	0.6966
36651169	Journal of hypertension	2023	"Circ_0001326 suppresses trophoblast cell proliferation, invasion, migration and epithelial-mesenchymal transition progression in preeclampsia by miR-188-3p/HtrA serine peptidase 1 axis."	hsa_circ_0001326	circ_0001326	hsa_circ_PHLDB2	PHLDB2	preeclampsia / PE	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR	"circ_0001326 is up-regulated in placental tissues from patients with preeclampsia and shows diagnostic value for distinguishing PE placentae from normal placentae. In trophoblast cells, circ_0001326 overexpression suppresses proliferation, invasion, migration and EMT while promoting apoptosis. Mechanistically, circ_0001326 functions through the miR-188-3p/HTRA1 axis by sponging miR-188-3p to regulate HTRA1."	0.7859
36670490	"American journal of reproductive immunology (New York, N.Y. : 1989)"	2023	"Hsa_circ_0001326 inhibited the proliferation, migration, and invasion of trophoblast cells via miR-145-5p/TGFB2 axis."	hsa_circ_0001326		hsa_circ_PHLDB2	PHLDB2	Preeclampsia / PE	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR	"Hsa_circ_0001326 is up-regulated in PE placentas and suppresses trophoblast cell viability, proliferation, migration, invasion, and EMT. Mechanistically, it sponges miR-145-5p to elevate TGFB2 expression, forming a hsa_circ_0001326/miR-145-5p/TGFB2 axis that may contribute to PE pathogenesis and serve as a potential biomarker or therapeutic target."	0.7759
36680938	Biochemical and biophysical research communications	2023	CircRNA mannosidase alpha class 1A member 2 promotes esophageal squamous cell carcinoma progression by regulating C-C chemokine ligand 5.		circRNA mannosidase alpha class 1A member 2 / circMAN1A2	hsa_circ_MAN1A2	MAN1A2	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; ISH	"circMAN1A2 is up-regulated in ESCC tissues and high expression is associated with poor overall survival. Functionally, circMAN1A2 promotes ESCC cell proliferation, migration and invasion, and its knockdown suppresses tumor growth in a xenograft model. Mechanistically, the study identifies CCL5 as a downstream target through which circMAN1A2 promotes ESCC progression, suggesting diagnostic, prognostic and therapeutic potential."	0.8262
36683504	Clinical hemorheology and microcirculation	2023	Circular RNA circ_0029589 promotes ox-LDL-induced endothelial cell injury through regulating RAB22A by serving as a sponge of miR-1197.	hsa_circ_0029589	circ 0029589 / circCHFR	hsa_circ_CHFR	CHFR	atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"circ 0029589 is up-regulated in serum from AS patients and in ox-LDL-treated HUVECs. It promotes ox-LDL-induced endothelial cell injury by sponging miR-1197 and regulating RAB22A, thereby suppressing proliferation, angiogenesis, and invasion while promoting apoptosis, inflammation, and oxidative stress. Its silencing shows protective effects in the in vitro AS endothelial injury model."	0.78
36689923	International archives of allergy and immunology	2023	Differential Circular RNA Expression Profiles in Induced Sputum of Patients with Asthma.			hsa_circ_SORT1	SORT1	asthma	MONDO:0004979	asthma	up-regulated	RT-qPCR; RNA-seq	has_circSORT1 was significantly up-regulated in induced sputum cells from asthma patients and correlated with lung function and inflammatory indicators. The study suggests a possible has_circSORT1/has-miR-185-3p/ZNFX1 ceRNA regulatory network in asthma airway epithelium and proposes has_circSORT1 as a potential diagnostic biomarker.	0.5047
36689923	International archives of allergy and immunology	2023	Differential Circular RNA Expression Profiles in Induced Sputum of Patients with Asthma.			hsa_circ_SERPINB1	SERPINB1	asthma	MONDO:0004979	asthma	up-regulated	RT-qPCR; RNA-seq	"has_circSERPINB1 was significantly up-regulated in induced sputum cells from asthma patients and correlated with lung function and inflammatory cytokine indicators. The study predicted and partially assessed a possible has_circSERPINB1/has-miR-146b-3p/FSCN1 ceRNA relationship, although the miRNA expression trend was not statistically significant, and proposed has_circSERPINB1 as a potential asthma diagnostic biomarker."	0.5047
36690073	Translational research : the journal of laboratory and clinical medicine	2023	CircRNA Uxs1/miR-335-5p/PGF axis regulates choroidal neovascularization via the mTOR/p70 S6k pathway.			hsa_circ_UXS1		age-related macular degeneration / AMD	MONDO:0005150	age-related macular degeneration	up-regulated	RT-qPCR; RNA-seq	"CircRNA Uxs1 is upregulated in CNV patient samples and laser-induced CNV mouse models. It promotes CNV-associated angiogenesis, endothelial proliferation, and migration by sponging miR-335-5p, thereby increasing PGF expression and activating the mTOR/p70 S6k pathway. Knockdown of circRNA Uxs1 suppresses endothelial angiogenic functions and reduces CNV lesions, supporting its potential as a therapeutic target."	0.7938
36690073	Translational research : the journal of laboratory and clinical medicine	2023	CircRNA Uxs1/miR-335-5p/PGF axis regulates choroidal neovascularization via the mTOR/p70 S6k pathway.			mmu_circ_Uxs1		age-related macular degeneration / AMD	MONDO:0005150	age-related macular degeneration	up-regulated	RT-qPCR; RNA-seq	"CircRNA Uxs1 is upregulated in CNV patient samples and laser-induced CNV mouse models. It promotes CNV-associated angiogenesis, endothelial proliferation, and migration by sponging miR-335-5p, thereby increasing PGF expression and activating the mTOR/p70 S6k pathway. Knockdown of circRNA Uxs1 suppresses endothelial angiogenic functions and reduces CNV lesions, supporting its potential as a therapeutic target."	0.7938
36696241	Journal of physiology and pharmacology : an official journal of the Polish Physiological Society	2022	Circular ribonucleic acid circ-FADS2 promotes colorectal cancer cell proliferation and invasion by regulating miR-498/S100A16.		circ-FADS2 / hsa_circRNA_100833	hsa_circ_FADS2	FADS2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ-FADS2 is upregulated in colorectal cancer and is associated with advanced stage, lymphatic metastasis, and poor overall survival. Functionally, it promotes CRC cell proliferation, invasion, and cell-cycle progression, at least in part by sponging miR-498 to upregulate S100A16 and activate the AKT pathway."	0.6536
36700761	International immunopharmacology	2023	Circ_0044411 silencing protects infantile pneumonia from lipopolysaccharide-induced cell injury by sponging miR-141-3p to inhibit CCL16 expression.	hsa_circ_0044411	circ_0044411 / circ-ZNF652	hsa_circ_ZNF652	ZNF652	infantile pneumonia / IP	MONDO:0005249	pneumonia	up-regulated	RT-qPCR	"This study found that circ_0044411 is up-regulated in serum from infantile pneumonia patients and in LPS-induced MRC-5 cells. Functionally, circ_0044411 knockdown protects against LPS-induced cell injury by promoting viability and proliferation while inhibiting apoptosis and inflammatory cytokine responses. Mechanistically, circ_0044411 sponges miR-141-3p to positively regulate CCL16 expression, suggesting a circ_0044411/miR-141-3p/CCL16 ceRNA axis and potential therapeutic relevance in infantile pneumonia."	0.8275
36702354	Toxicon : official journal of the International Society on Toxinology	2023	A novel circular RNA circNLRP3 alleviated ricin toxin-induced TNF-alpha production through sponging miR-221-5p.		circNLRP3 / CircRNA1696	mmu_circ_NLRP3	NLRP3	RT-induced inflammation	MONDO:0043459	radiation-induced disorder	up-regulated	RT-qPCR; RNA-seq	"circNLRP3 is a novel mouse circRNA derived from NLRP3 and up-regulated in RT-induced RAW264.7 macrophage inflammation. It functions as a cytoplasmic miR-221-5p sponge, relieves repression of A20, suppresses NF-kappaB signaling, and alleviates TNF-alpha production."	0.7929
36703078	British journal of cancer	2023	Plasma extracellular vesicle circRNA signature and resistance to abiraterone in metastatic castration-resistant prostate cancer.		circCEP112	hsa_circ_CEP112	CEP112	castration-resistant prostate cancer	MONDO:0850353	castration-resistant prostate carcinoma	dysregulated	RT-qPCR; RNA-seq	"circCEP112 is one of five plasma extracellular vesicle circRNAs selected for an mCRPC prognostic signature in patients receiving first-line abiraterone. Its positive coefficient in the risk-score formula suggests that higher circCEP112 expression contributes to a higher-risk signature, which is associated with shorter overall survival."	0.6759
36703078	British journal of cancer	2023	Plasma extracellular vesicle circRNA signature and resistance to abiraterone in metastatic castration-resistant prostate cancer.		circFAM13A	hsa_circ_FAM13A	FAM13A	castration-resistant prostate cancer	MONDO:0850353	castration-resistant prostate carcinoma	dysregulated	RT-qPCR; RNA-seq	"circFAM13A is one of five plasma extracellular vesicle circRNAs selected for an mCRPC prognostic signature in patients receiving first-line abiraterone. Its positive coefficient in the risk-score formula suggests that higher circFAM13A expression contributes to a higher-risk signature, which is associated with shorter overall survival."	0.6759
36703078	British journal of cancer	2023	Plasma extracellular vesicle circRNA signature and resistance to abiraterone in metastatic castration-resistant prostate cancer.		circBRWD1	hsa_circ_BRWD1	BRWD1	castration-resistant prostate cancer	MONDO:0850353	castration-resistant prostate carcinoma	dysregulated	RT-qPCR; RNA-seq	"circBRWD1 is one of five plasma extracellular vesicle circRNAs selected for an mCRPC prognostic signature in patients receiving first-line abiraterone. Its positive coefficient in the risk-score formula suggests that higher circBRWD1 expression contributes to a higher-risk signature, which is associated with shorter overall survival; the discussion also notes prior evidence linking circBRWD1 to prostate cancer cell proliferation."	0.6759
36703078	British journal of cancer	2023	Plasma extracellular vesicle circRNA signature and resistance to abiraterone in metastatic castration-resistant prostate cancer.		circVPS13C	hsa_circ_VPS13C	VPS13C	castration-resistant prostate cancer	MONDO:0850353	castration-resistant prostate carcinoma	dysregulated	RT-qPCR; RNA-seq	"circVPS13C is one of five plasma extracellular vesicle circRNAs selected for an mCRPC prognostic signature in patients receiving first-line abiraterone. Its negative coefficient in the risk-score formula suggests that higher circVPS13C expression contributes to a lower-risk signature, which is associated with longer overall survival; the discussion also notes prior evidence linking circVPS13C to prostate cancer cell proliferation."	0.6759
36703078	British journal of cancer	2023	Plasma extracellular vesicle circRNA signature and resistance to abiraterone in metastatic castration-resistant prostate cancer.		circMACROD2	hsa_circ_MACROD2	MACROD2	castration-resistant prostate cancer	MONDO:0850353	castration-resistant prostate carcinoma	dysregulated	RT-qPCR; RNA-seq	"circMACROD2 is one of five plasma extracellular vesicle circRNAs selected for an mCRPC prognostic signature in patients receiving first-line abiraterone. Its negative coefficient in the risk-score formula suggests that higher circMACROD2 expression contributes to a lower-risk signature, which is associated with longer overall survival, although its biological role in mCRPC remains unknown."	0.6759
36705303	General physiology and biophysics	2023	Circ_0001498 contributes to lipopolysaccharide-induced lung cell apoptosis and inflammation in sepsis-related acute lung injury via upregulating SOX6 by interacting with miR-574-5p.	hsa_circ_0001498	circ_0001498	hsa_circ_WDR41	WDR41	sepsis-induced acute lung injury	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR	"circ_0001498 is up-regulated in serum from sepsis-related ALI patients and in LPS-treated WI-38 cells. It promotes LPS-induced lung cell apoptosis and inflammatory responses by sponging miR-574-5p and thereby increasing SOX6 expression. Knockdown of circ_0001498 alleviates LPS-induced WI-38 cell injury, supporting its pathogenic role in sepsis-associated ALI."	0.8107
36705889	"Cellular oncology (Dordrecht, Netherlands)"	2023	circRNA_0067717 promotes paclitaxel resistance in nasopharyngeal carcinoma by acting as a scaffold for TRIM41 and p53.	hsa_circ_0067717	circRNA_0067717	hsa_circ_RNF13	RNF13	nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; ISH; Microarray	"hsa_circ_0067717/circRNA_0067717 is upregulated in paclitaxel-resistant NPC cell lines. It promotes paclitaxel chemoresistance by acting as a scaffold that brings TRIM41 and p53 together, enhancing TRIM41-mediated ubiquitination and degradation of p53. Blocking the TRIM41 or p53 binding regions on circRNA_0067717 restores p53 stability and increases paclitaxel sensitivity."	0.852
36708978	European journal of pharmacology	2023	Comprehensive analysis of the RNA transcriptome expression profiles and construction of the ceRNA network in heart failure patients with sacubitril/valsartan therapeutic heterogeneity after acute myocardial infarction.	hsa_circ_0003275				heart failure / HF	MONDO:0005252	heart failure	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_0003275 was down-regulated in SVR patients with HF after AMI and was validated by qRT-PCR in clinical PBMC samples. The study incorporated it into predicted circRNA-miRNA-mRNA and circRNA-lncRNA ceRNA networks, suggesting possible roles in inflammatory and lipid-metabolism-related regulation of sacubitril/valsartan therapeutic heterogeneity."	0.4032
36708978	European journal of pharmacology	2023	Comprehensive analysis of the RNA transcriptome expression profiles and construction of the ceRNA network in heart failure patients with sacubitril/valsartan therapeutic heterogeneity after acute myocardial infarction.	hsa_circ_0004494				heart failure / HF	MONDO:0005252	heart failure	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_0004494 was down-regulated in SVR patients with HF after AMI and was validated by qRT-PCR in clinical PBMC samples. The study incorporated it into predicted circRNA-miRNA-mRNA and circRNA-lncRNA ceRNA networks, suggesting possible roles in inflammatory and lipid-metabolism-related regulation of sacubitril/valsartan therapeutic heterogeneity."	0.4032
36708978	European journal of pharmacology	2023	Comprehensive analysis of the RNA transcriptome expression profiles and construction of the ceRNA network in heart failure patients with sacubitril/valsartan therapeutic heterogeneity after acute myocardial infarction.	hsa_circ_0093522				heart failure / HF	MONDO:0005252	heart failure	down-regulated	RT-qPCR; Microarray	"hsa_circ_0093522 was down-regulated in SVR patients with HF after AMI and was validated by qRT-PCR in clinical PBMC samples. The study incorporated it into predicted circRNA-miRNA-mRNA and circRNA-lncRNA ceRNA networks, suggesting possible roles in inflammatory and lipid-metabolism-related regulation of sacubitril/valsartan therapeutic heterogeneity."	0.4032
36708978	European journal of pharmacology	2023	Comprehensive analysis of the RNA transcriptome expression profiles and construction of the ceRNA network in heart failure patients with sacubitril/valsartan therapeutic heterogeneity after acute myocardial infarction.	hsa_circ_0137499				heart failure / HF	MONDO:0005252	heart failure	up-regulated	RT-qPCR; Microarray	"hsa_circ_0137499 was up-regulated in SVR patients with HF after AMI and was validated by qRT-PCR in clinical PBMC samples. The study incorporated it into predicted circRNA-miRNA-mRNA and circRNA-lncRNA ceRNA networks, suggesting possible roles in inflammatory and lipid-metabolism-related regulation of sacubitril/valsartan therapeutic heterogeneity."	0.4032
36714978	Histology and histopathology	2023	"Hsa_circ_0072765 knockdown inhibits proliferation, activation and migration in transforming growth factor-beta (TGF-beta)-induced hepatic stellate cells (HSCs) by the miR-197-3p/TRPV3 axis."	hsa_circ_0072765		hsa_circ_CCNB1	CCNB1	liver fibrosis	MONDO:0005155	cirrhosis of liver	up-regulated	RT-qPCR	"This study found that hsa_circ_0072765 is up-regulated in a TGF-beta1-induced LX2 hepatic stellate cell model of liver fibrosis and in exosomes from these cells. Functionally, hsa_circ_0072765 promotes HSC proliferation, cell cycle progression, activation and migration. Mechanistically, it sponges miR-197-3p to increase TRPV3 expression, forming a hsa_circ_0072765/miR-197-3p/TRPV3 regulatory axis relevant to liver fibrosis."	0.7615
36715182	Environmental toxicology	2023	Splicing factor SNRPA associated with microvascular invasion promotes hepatocellular carcinoma metastasis through activating NOTCH1/Snail pathway and is mediated by circSEC62/miR-625-5p axis.	hsa_circ_0001358	circSEC62	hsa_circ_SEC62	SEC62	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circSEC62 is up-regulated in HCC, especially MVI-HCC, and its high expression is associated with poorer OS and RFS. It promotes HCC cell migration, invasion, EMT-like changes, and lung metastasis by sponging miR-625-5p, thereby increasing SNRPA expression and activating the NOTCH1/Snail pathway."	0.8658
36715861	Molecular biotechnology	2023	Hsa_circ_0119412 Contributes to Development of Retinoblastoma by Targeting miR-186-5p/ELK4 Axis.	hsa_circ_0119412	circ_0119412 / hsa_cir-cRNA_102958			retinoblastoma / RB	MONDO:0008380	retinoblastoma	up-regulated	RT-qPCR	"hsa_circ_0119412 is upregulated in retinoblastoma tissues and cells. It promotes RB progression by sponging miR-186-5p and upregulating ELK4, thereby enhancing proliferation, migration and tumor growth while suppressing apoptosis. The study suggests circ_0119412 as a potential therapeutic target for RB."	0.7785
36715959	International ophthalmology	2023	Circ_0006667 contributes to high glucose-induced retinal pigment epithelial cell dysfunction by mediating miR-7-5p/TGFA axis in diabetic retinopathy.	hsa_circ_0006667	circ_0006667	hsa_circ_KLHL24	KLHL24	Diabetic retinopathy / DR	MONDO:0005266	diabetic retinopathy	up-regulated	RT-qPCR	"circ_0006667 is up-regulated in serum from DR patients and in HG-induced ARPE-19 cells. Functionally, circ_0006667 promotes HG-induced RPE cell dysfunction by inhibiting proliferation and enhancing apoptosis and inflammation. Mechanistically, it acts as a miR-7-5p sponge to increase TGFA expression, and silencing circ_0006667 protects ARPE-19 cells through the miR-7-5p/TGFA axis."	0.7795
36716953	Journal of molecular and cellular cardiology	2023	Circ-calm4 regulates hypoxia-induced pulmonary artery smooth muscle autophagy by binding Purb.		circRNA calmodulin 4 / circ-calm4	mmu_circ_calm4	calmodulin 4	pulmonary hypertension / PH	MONDO:0005149	pulmonary hypertension	up-regulated	RT-qPCR; RNA-seq	"circ-calm4 is up-regulated under hypoxic pulmonary hypertension conditions in mouse PASMCs and PH models. It promotes hypoxia-induced autophagy and PASMC proliferation by binding Purb, enhancing Purb nuclear expression, and promoting Beclin1 transcription through super-enhancer-associated regulation. Knockdown of circ-calm4 reverses hypoxia-induced autophagy in vitro and in vivo."	0.7796
36717528	Functional & integrative genomics	2023	Circular hsa_circ_0020377 regulates KLF7 by targeting miR-194-5p to facilitate tumor cell malignant behaviors and glycolysis in oral squamous cell carcinoma progression.	hsa_circ_0020377		hsa_circ_ADAM12	ADAM12	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"hsa_circ_0020377 is up-regulated in OSCC tissues and cell lines and acts as an oncogenic circRNA. It promotes OSCC proliferation, cell cycle progression, migration, invasion, glycolysis, and xenograft tumor growth by sponging miR-194-5p and increasing KLF7 expression. The study suggests the hsa_circ_0020377/miR-194-5p/KLF7 axis as a potential therapeutic target in OSCC."	0.7982
36718820	Histology and histopathology	2023	circRNA-SMO upregulates CEP85 to promote proliferation and migration of glioblastoma via sponging miR-326.		circRNA-SMO	hsa_circ_SMO	SMO	glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR	"circRNA-SMO is upregulated in glioblastoma tissues and cell lines and high expression is associated with poor prognosis. Functionally, circRNA-SMO promotes glioblastoma proliferation, colony formation, migration, invasion, and xenograft tumor growth while suppressing apoptosis. Mechanistically, it acts as a ceRNA by sponging miR-326, thereby increasing CEP85 expression."	0.722
36720469	Molecular and cellular biology	2023	Exosome-transmitted circIFNGR2 Modulates Ovarian Cancer Metastasis via miR-378/ST5 Axis.	hsa_circ_0001185	circIFNGR2	hsa_circ_IFNGR2	IFNGR2	ovarian cancer / OC	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR	"circIFNGR2 is down-regulated in OVCA tissues and cell lines and can be transferred from CAF-derived exosomes into OVCA cells. It suppresses OVCA proliferation, migration, invasion, EMT, tumor growth and metastatic progression through a circIFNGR2/miR-378/ST5 ceRNA axis, and it shows potential diagnostic value for OVCA."	0.8615
36723877	FASEB journal : official publication of the Federation of American Societies for Experimental Biology	2023	Human umbilical cord mesenchymal stem cells-derived exosomal circDLGAP4 promotes angiogenesis after cerebral ischemia-reperfusion injury by regulating miR-320/KLF5 axis.			hsa_circ_DLGAP4	DLGAP4	cerebral ischemia-reperfusion injury	MONDO:0005203	ischemia reperfusion injury	down-regulated	RT-qPCR	"This study shows that hUC-MSC-derived exosomal circDLGAP4 is reduced under H/R or I/R injury conditions but can be restored by hUC-MSC exosome treatment. Exosomal circDLGAP4 protects against cerebral ischemia-reperfusion injury by sponging miR-320, increasing KLF5, activating PI3K/AKT signaling, promoting angiogenesis-related endothelial functions, and reducing apoptosis and cerebrovascular injury."	0.7053
36725075	International heart journal	2023	Circ_0001312 Silencing Suppresses Doxorubicin-Induced Cardiotoxicity via MiR-409-3p/HMGB1 Axis.	hsa_circ_0001312		hsa_circ_CCDC66	CCDC66	Doxorubicin-induced cardiotoxicity	MONDO:0023006	doxorubicin induced cardiomyopathy	up-regulated	RT-qPCR	"In DOX-treated human AC16 cardiomyocytes, circ_0001312 is up-regulated and contributes to cardiomyocyte injury by suppressing proliferation and promoting apoptosis, inflammation, and oxidative stress. Mechanistically, circ_0001312 functions as a ceRNA for miR-409-3p to increase HMGB1 expression, and it can also be secreted and transferred via exosomes."	0.7446
36727737	Anti-cancer drugs	2023	Circ_0091537 promotes gefitinib chemoresistance in non-small cell lung cancer by mediating the miR-520h/YAP1 network.	hsa_circ_0091537		hsa_circ_PDZD8	PDZD8	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0091537 is up-regulated in gefitinib-resistant NSCLC cells and tumor samples. It promotes gefitinib chemoresistance and malignant behaviors by sponging miR-520h to increase YAP1 expression. Knockdown of circ_0091537 reduces IC50, suppresses proliferation, migration, invasion, and tumor growth, and enhances apoptosis and gefitinib sensitivity."	0.8175
36728267	Journal of hypertension	2023	CircRNA_06354 might promote early-onset preeclampsia in humans via hsa-miR-92a-3p/vascular endothelial growth factor-A.		circRNA_06354	hsa_circ_Metrnl	Metrnl	early-onset preeclampsia / EOPE	MONDO:0005081	preeclampsia	dysregulated	RT-qPCR; Northern Blot; ISH; RNA-seq	"circRNA_06354 is dysregulated in EOPE, with decreased levels in blood cells and increased levels in placental samples. It is mainly cytoplasmic in HTR-8/SV-neo cells and appears to promote EOPE pathogenesis by suppressing trophoblastic cell migration, invasion and tube formation, possibly through a circRNA_06354/hsa-miR-92a-3p/VEGF-A regulatory axis. Its expression showed strong diagnostic performance for EOPE in this study."	0.84
36728962	Anti-cancer drugs	2023	Circular RNA circ_0005667 promotes cisplatin resistance of endometrial carcinoma cells by regulating IGF2BP1 through miR-145-5p.	hsa_circ_0005667	circ_0005667	hsa_circ_ZNF124	ZNF124	endometrial cancer / EC	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR	"circ_0005667 is up-regulated in cisplatin-resistant endometrial carcinoma tissues and cells. It promotes DDP resistance, proliferation, migration, invasion and in vivo tumor growth while suppressing apoptosis, mainly through the circ_0005667/miR-145-5p/IGF2BP1 regulatory axis."	0.8006
36729102	Anti-cancer drugs	2023	Circular RNA circ_0000212 accelerates cervical cancer progression by acting as a miR-625-5p sponge to upregulate PTP4A1.	hsa_circ_0000212	circ_0000212	hsa_circ_SFMBT2	SFMBT2	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ_0000212 is up-regulated in cervical cancer tissues and cells and functions as an oncogenic circRNA. Its knockdown suppresses proliferation, migration, invasion, angiogenesis and xenograft tumor growth while promoting apoptosis. Mechanistically, circ_0000212 sponges miR-625-5p to positively regulate PTP4A1, forming a circ_0000212/miR-625-5p/PTP4A1 ceRNA axis."	0.8006
36729852	Anti-cancer drugs	2023	CircSETDB1 contributes to paclitaxel resistance of ovarian cancer cells by sponging miR-508-3p and regulating ABCC1 expression.	hsa_circ_0006352	circRNA SET domain bifurcated histone lysine methyltransferase 1 / circSETDB1	hsa_circ_SETDB1	SETDB1	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"CircSETDB1 is up-regulated in paclitaxel-resistant ovarian cancer tissues and cells and high expression is associated with poor prognosis. Functionally, circSETDB1 promotes paclitaxel resistance, proliferation and cell-cycle progression while suppressing apoptosis. Mechanistically, it functions as a cytoplasmic miR-508-3p sponge to increase ABCC1 expression, forming a circSETDB1/miR-508-3p/ABCC1 axis that contributes to paclitaxel resistance."	0.8353
36729977	Anti-cancer drugs	2023	Circ_0058063 regulates the development of esophageal cancer through miR-377-3p/HOXA1 axis.	hsa_circ_0058063	circ_0058063			esophageal cancer	MONDO:0007576	esophageal cancer	up-regulated	RT-qPCR; Microarray	"circ_0058063 is up-regulated in esophageal cancer tissues and cell lines. Functional knockdown experiments showed that it promotes proliferation, migration, invasion, glycolysis and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ_0058063 regulates HOXA1 expression by targeting miR-377-3p."	0.7955
36730287	Anti-cancer drugs	2023	Circular RNA circ_0003028 regulates cell development through modulating miR-498/ornithine decarboxylase 1 axis in hepatocellular carcinoma.	hsa_circ_0003028	circ_0003028	hsa_circ_FUT8	FUT8	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0003028 is up-regulated in HCC tissues, cells and patient plasma/serum exosomes. It promotes HCC proliferation, migration, invasion, EMT and in vivo tumor growth while suppressing apoptosis, mainly through a circ_0003028/miR-498/ODC1 ceRNA axis and exosome-mediated EMT promotion. The study suggests circ_0003028 may serve as a biomarker and therapeutic target for HCC."	0.8175
36730544	Anti-cancer drugs	2023	CircBNC2 affects epithelial ovarian cancer progression through the miR-223-3p/ LARP4 axis.		Circular RNA BNC2 / circBNC2	hsa_circ_BNC2	BNC2	epithelial ovarian cancer / EOC	MONDO:0005140	ovarian carcinoma	down-regulated	RT-qPCR	"circBNC2 is down-regulated in epithelial ovarian cancer tissues and cell lines and functions as a tumor suppressor. It sponges miR-223-3p to increase LARP4 expression, thereby inhibiting EOC cell proliferation, migration, invasion, EMT-associated protein expression, and xenograft tumor growth while promoting apoptosis."	0.8467
36730613	Anti-cancer drugs	2023	CircRNA circ_POLA2 overexpression suppresses cell apoptosis by downregulating PTEN in glioblastoma.		circ_POLA2	hsa_circ_POLA2		glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR	"This study reports that circ_POLA2 is upregulated in human GBM tissues. Functionally, circ_POLA2 overexpression suppresses apoptosis of GBM cell lines and reduces PTEN expression at both mRNA and protein levels, suggesting a circ_POLA2/PTEN-related anti-apoptotic mechanism in GBM."	0.5358
36730637	Anti-cancer drugs	2023	Knockdown of circ-PIP5K1A overcomes resistance to cisplatin in ovarian cancer by miR-942-5p/NFIB axis.	hsa_circ_0014130	Circular RNA PIP5K1A / circ-PIP5K1A	hsa_circ_PIP5K1A	PIP5K1A	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circ-PIP5K1A is up-regulated in ovarian cancer, especially in cisplatin-resistant tissues and cells. It promotes cisplatin resistance and malignant phenotypes by sponging miR-942-5p to increase NFIB expression, and its knockdown sensitizes ovarian cancer cells and xenograft tumors to cisplatin. The study also shows that circ-PIP5K1A can be packaged into exosomes and transferred from resistant cells to surrounding sensitive cells."	0.7663
36732429	Molecular neurobiology	2023	Extracellular Vesicles Derived from Bone Mesenchymal Stem Cells Carrying circ_0000075 Relieves Cerebral Ischemic Injury by Competitively Inhibiting miR-218-5p and Up-regulating E3 Ubiquitin Ligase SMURF2.	mmu_circ_0000075	circ_0000075			ischemic stroke / IS	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR; RNA-seq	"circ_0000075 is down-regulated in MCAO-induced cerebral ischemic injury. Engineered BMSC-derived extracellular vesicles deliver circ_0000075 to brain tissues and neurons, where it binds miR-218-5p to relieve repression of SMURF2 and subsequently reduce YY1 protein stability. Up-regulation of circ_0000075 attenuates neuronal injury, decreases infarct areas, promotes neuronal survival, and inhibits apoptosis."	0.7825
36735043	Experimental brain research	2023	Circvrk1 downregulation attenuates brain microvascular endothelial cell damage induced by oxygen-glucose deprivation through modulating the miR-150-5p/MLLT1 axis.	hsa_circ_0000566	circVRK1	hsa_circ_VRK1	VRK1	ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR	"CircVRK1 is upregulated in OGD-treated HBMECs, an in vitro model of ischemic stroke. Its knockdown protects HBMECs from OGD-induced injury by reducing cell death, inflammation and oxidative stress while improving migration and angiogenesis, mediated through the miR-150-5p/MLLT1 ceRNA axis."	0.7624
36735415	Acta biochimica Polonica	2023	circ_0013613 Promotes the recovery of spinal cord injury by regulating mir-370-3p/caspase1 to regulate neuronal pyroptosis.	hsa_circ_0013613	circ_0013613			spinal cord injury / SCI	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR	"circ_0013613 is up-regulated in SCI patient blood samples and LPS-induced primary spinal cord neurons. Mechanistically, it competitively binds miR-370-3p and regulates CASP1, thereby promoting inflammatory response and neuronal pyroptosis; circ_0013613 knockdown alleviates neuronal injury and may support SCI recovery."	0.7936
36735415	Acta biochimica Polonica	2023	circ_0013613 Promotes the recovery of spinal cord injury by regulating mir-370-3p/caspase1 to regulate neuronal pyroptosis.		circ_0013613			spinal cord injury / SCI	MONDO:0043797	spinal cord injury	up-regulated	RT-qPCR	"circ_0013613 is up-regulated in SCI patient blood samples and LPS-induced primary spinal cord neurons. Mechanistically, it competitively binds miR-370-3p and regulates CASP1, thereby promoting inflammatory response and neuronal pyroptosis; circ_0013613 knockdown alleviates neuronal injury and may support SCI recovery."	0.7936
36736867	Gene	2023	Mechanism of circular RNA-mediated regulation of L-DOPA to improve wet age-related macular degeneration.	hsa_circ_0018401	circ-SGMS1 / circ_0018401	hsa_circ_SGMS1	SGMS1	age-related macular degeneration / AMD	MONDO:0005150	age-related macular degeneration	down-regulated	RT-qPCR; RNA-seq	"circ-SGMS1/hsa_circ_0018401 is down-regulated in the CoCl2-induced wet AMD ARPE-19 cell model. Its overexpression protects ARPE-19 cells by promoting proliferation, reducing apoptosis, restoring PEDF, TYR and melanin-related effects, and inhibiting HIF-1a and THBS1/TGFbeta-related signaling."	0.6969
36736867	Gene	2023	Mechanism of circular RNA-mediated regulation of L-DOPA to improve wet age-related macular degeneration.	hsa_circ_0007064				age-related macular degeneration / AMD	MONDO:0005150	age-related macular degeneration	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0007064 was identified by circRNA sequencing and validated by qRT-PCR as up-regulated in the CoCl2-induced wet AMD ARPE-19 cell model. No specific functional or mechanistic role was further tested for this circRNA.	0.329
36736867	Gene	2023	Mechanism of circular RNA-mediated regulation of L-DOPA to improve wet age-related macular degeneration.	hsa_circ_0003915				age-related macular degeneration / AMD	MONDO:0005150	age-related macular degeneration	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0003915 was among the qRT-PCR-validated differentially expressed circRNAs and was down-regulated in the CoCl2-induced wet AMD cell model. No specific functional mechanism was experimentally tested for this circRNA.	0.329
36736867	Gene	2023	Mechanism of circular RNA-mediated regulation of L-DOPA to improve wet age-related macular degeneration.	hsa_circ_0005768				age-related macular degeneration / AMD	MONDO:0005150	age-related macular degeneration	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0005768 was qRT-PCR-validated as one of the down-regulated circRNAs in the CoCl2-induced wet AMD cell model. The paper did not experimentally define its biological function or molecular mechanism.	0.329
36736867	Gene	2023	Mechanism of circular RNA-mediated regulation of L-DOPA to improve wet age-related macular degeneration.	hsa_circ_0007444				age-related macular degeneration / AMD	MONDO:0005150	age-related macular degeneration	down-regulated	RT-qPCR; RNA-seq	hsa_circ_0007444 was qRT-PCR-validated as a down-regulated circRNA in the CoCl2-induced wet AMD ARPE-19 cell model. No downstream biological role was further characterized.	0.329
36736867	Gene	2023	Mechanism of circular RNA-mediated regulation of L-DOPA to improve wet age-related macular degeneration.	hsa_circ_0001451				age-related macular degeneration / AMD	MONDO:0005150	age-related macular degeneration	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001451 was down-regulated in the CoCl2-induced wet AMD model and up-regulated after L-DOPA treatment plus CoCl2 compared with CoCl2 alone, according to qRT-PCR validation. Its functional mechanism was not further explored."	0.329
36738165	Human & experimental toxicology	2023	Circ_0000285 regulates nasopharyngeal carcinoma progression through miR-1278/FNDC3B axis.	hsa_circ_0000285	Circ_0000285			Nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR	"Circ_0000285 is up-regulated in NPC tissues and cell lines. It promotes NPC progression by sponging miR-1278 and increasing FNDC3B expression, thereby enhancing proliferation, migration, invasion and tumor growth while suppressing apoptosis. The study suggests circ_0000285 may serve as a diagnostic biomarker and therapeutic target for NPC."	0.7132
36738282	Human & experimental toxicology	2023	CircKRT14 upregulates E2F3 by interacting with miR-1256 to act as an oncogenic factor in esophageal cancer.		circRNA Keratin 14 / circKRT14	hsa_circ_KRT14	KRT14	esophageal cancer	MONDO:0007576	esophageal cancer	up-regulated	RT-qPCR	"circKRT14 is up-regulated in esophageal cancer tissues and cells and acts as an oncogenic circRNA. It promotes proliferation, migration, invasion and tumor growth while suppressing apoptosis, mainly by sponging miR-1256 to increase E2F3 expression through the circKRT14/miR-1256/E2F3 axis. The study suggests circKRT14 may serve as a potential diagnostic and therapeutic target for EC."	0.7661
36740786	The journal of gene medicine	2023	circANKRD28 inhibits cisplatin resistance in non-small-cell lung cancer through the miR-221-3p/SOCS3 axis.		circANKRD28	hsa_circ_ANKRD28	ANKRD28	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR	"circANKRD28 is downregulated in NSCLC, especially in DDP-resistant tissues and cells. Its overexpression suppresses malignant phenotypes and cisplatin resistance by sponging miR-221-3p and relieving repression of SOCS3, thereby increasing DDP sensitivity in vitro and in vivo."	0.8571
36743510	American journal of cardiovascular disease	2022	Construction of the ceRNA network in the progression of acute myocardial infarction.	hsa_circ_0023461	circRNA_023461 / circ_0023461			acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	up-regulated	Microarray	"circRNA_023461 was identified from the GSE160717 circRNA microarray dataset as up-regulated in AMI and was included in a predicted ceRNA network. The study suggests that it regulates potential miRNA-mRNA axes involving miR-324-5p, miR-326, miR-590-5p and immune-related hub genes, thereby potentially contributing to AMI progression."	0.1768
36743510	American journal of cardiovascular disease	2022	Construction of the ceRNA network in the progression of acute myocardial infarction.	hsa_circ_0092367	circRNA_400027 / circ_0092367			acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	up-regulated	Microarray	"circRNA_400027 was identified from the GSE160717 circRNA microarray dataset as up-regulated in AMI and was included in a predicted ceRNA network. The study suggests that it regulates potential miRNA-mRNA axes involving miR-324-5p, miR-326, miR-590-5p and immune-related hub genes, thereby potentially contributing to AMI progression."	0.1768
36743510	American journal of cardiovascular disease	2022	Construction of the ceRNA network in the progression of acute myocardial infarction.		circRNA_038011			acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	dysregulated	Microarray	"circRNA_038011 was identified as one of five differentially expressed circRNA candidates in AMI using the GSE160717 microarray dataset. The study did not report a specific direction of expression, ceRNA axis, functional mechanism, or experimental validation for this circRNA."	0.1768
36743510	American journal of cardiovascular disease	2022	Construction of the ceRNA network in the progression of acute myocardial infarction.		circRNA_400564			acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	dysregulated	Microarray	"circRNA_400564 was identified as one of five differentially expressed circRNA candidates in AMI using the GSE160717 microarray dataset. The study did not report a specific direction of expression, ceRNA axis, functional mechanism, or experimental validation for this circRNA."	0.1768
36743510	American journal of cardiovascular disease	2022	Construction of the ceRNA network in the progression of acute myocardial infarction.		cir-cRNA_400101			acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	dysregulated	Microarray	"cir-cRNA_400101 was identified as one of five differentially expressed circRNA candidates in AMI using the GSE160717 microarray dataset. The study did not report a specific direction of expression, ceRNA axis, functional mechanism, or experimental validation for this circRNA."	0.1768
36745282	Molecular biotechnology	2023	Circ_TEX2 Functions as a Tumor Suppressor in Hepatoma via miR-96-5p/SPRED1 Axis.	hsa_circ_0004913	circRNA testis expressed 2 / circ_TEX2	hsa_circ_TEX2	TEX2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"Circ_TEX2 is down-regulated in hepatoma tissues and cells and acts as a tumor suppressor. Mechanistically, circ_TEX2 sponges miR-96-5p to increase SPRED1 expression, thereby inhibiting hepatoma cell proliferation, migration, invasion, and xenograft tumor growth while promoting apoptosis. The study suggests that restoring circ_TEX2 may have therapeutic potential for hepatoma."	0.7955
36748197	Laboratory investigation; a journal of technical methods and pathology	2023	circ_rac GTPase-Activating Protein 1 Facilitates Stemness and Metastasis of Non-Small Cell Lung Cancer via Polypyrimidine Tract-Binding Protein 1 Recruitment to Promote Sirtuin-3-Mediated Replication Timing Regulatory Factor 1 Deacetylation.		circ_rac GTPaseeactivating protein 1 / hsa_circ_101053	hsa_circ_RACGAP1	RACGAP1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circRACGAP1 is upregulated in NSCLC tissues, cell lines, and serum-derived exosomes, and high exosomal circRACGAP1 is associated with poor overall survival. Functionally, circRACGAP1 promotes NSCLC stemness, EMT, migration, invasion, tumor growth, and metastasis. Mechanistically, it recruits PTBP1 to stabilize SIRT3, leading to RIF1 deacetylation and activation of the Wnt/beta-catenin pathway."	0.8768
36757296	"Reproduction (Cambridge, England)"	2023	Identification of circular RNAs as regulators and noninvasive biomarkers for placenta accreta spectrum.		circPHACTR4	hsa_circ_PHACTR4	PHACTR4	Placenta accreta spectrum / PAS	MONDO:0005916	placenta accreta	up-regulated	RT-qPCR; RNA-seq	"circPHACTR4 is upregulated in PAS placenta and maternal blood. It promotes trophoblast migration and invasion, likely through a circPHACTR4/miR-206/VEGFA ceRNA-related mechanism, and shows noninvasive biomarker potential for prenatal PAS prediction."	0.8111
36757296	"Reproduction (Cambridge, England)"	2023	Identification of circular RNAs as regulators and noninvasive biomarkers for placenta accreta spectrum.		circZMYM4	hsa_circ_ZMYM4	ZMYM4	Placenta accreta spectrum / PAS	MONDO:0005916	placenta accreta	up-regulated	RT-qPCR; RNA-seq	"circZMYM4 is upregulated in PAS placenta and maternal blood. It promotes trophoblast migration and invasion, likely through a circZMYM4/miR-137/TCF4 ceRNA-related mechanism, and shows noninvasive biomarker potential for prenatal PAS prediction."	0.8111
36757626	General thoracic and cardiovascular surgery	2023	Circ_0024108 promotes the progression of esophageal cancer cells.	hsa_circ_0024108	circ_0024108 / circMMP1	hsa_circ_MMP1	MMP1	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"circ_0024108 is up-regulated in ESCC tumors, ESCC cell lines, and serum exosomes, and high expression is associated with poor prognosis. It promotes ESCC cell proliferation, motility, invasion, and xenograft tumorigenicity by sponging miR-488-3p and increasing USP14 expression. Exosomal circ_0024108 can mediate cell-to-cell communication and may serve as a diagnostic biomarker for ESCC."	0.8282
36758707	Biochemical pharmacology	2023	Inhibition of circular RNA ASPH reduces the proliferation and promotes the apoptosis of hepatic stellate cells in hepatic fibrosis.	mmu_circ_0001182	circASPH	mmu_circ_ASPH	ASPH	hepatic fibrosis	MONDO:0005155	cirrhosis of liver	up-regulated	RT-qPCR; ISH; RNA-seq	"Mouse circASPH (mmu_circ_0001182), derived from ASPH, is up-regulated during CCl4-induced hepatic fibrosis. It promotes HSC activation and proliferation and suppresses apoptosis by sponging miR-139-5p and increasing Notch1 expression; its knockdown shows anti-fibrotic effects in mice."	0.8355
36758707	Biochemical pharmacology	2023	Inhibition of circular RNA ASPH reduces the proliferation and promotes the apoptosis of hepatic stellate cells in hepatic fibrosis.	hsa_circ_0009158	circASPH	hsa_circ_ASPH	ASPH	hepatic fibrosis	MONDO:0005155	cirrhosis of liver	up-regulated	RT-qPCR; ISH	"Human hsa_circ_0009158 is described as a homologous circASPH and is up-regulated in HC/HCC serum, HCC cancer tissues, and TGF-beta1-treated LX-2 cells. Functionally, circASPH promotes HSC activation and proliferation and inhibits apoptosis, likely through the miR-139-5p/Notch1 axis, suggesting potential diagnostic and therapeutic relevance in liver fibrosis-related disease."	0.8206
36763221	Biochemical genetics	2023	Circ_0084188 Regulates the progression of colorectal cancer through the miR-769-5p/KIF20A axis.	hsa_circ_0084188	circ_0084188	hsa_circ_KIAA0146	KIAA0146	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0084188 is up-regulated in colorectal cancer tissues and cell lines, and high expression is associated with larger tumor size, advanced TNM stage, and poorer overall survival. Functionally, circ_0084188 promotes CRC proliferation, migration, invasion, EMT and xenograft tumor growth while suppressing apoptosis. Mechanistically, it sponges miR-769-5p to increase KIF20A expression, forming a circ_0084188/miR-769-5p/KIF20A regulatory axis."	0.8712
36763305	Molecular biotechnology	2023	Hsa_circ_0017956 Acts as miR-758-3p Sponge to Facilitate the Progression of Non-small-Cell Lung Cancer by Regulating FOXP4 Expression.	hsa_circ_0017956	circ_0017956	hsa_circ_MLLT10	MLLT10	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"In this study, circ_0017956 was upregulated in NSCLC tissues and cells and was associated with advanced TNM stage and lymph node metastasis. Functional assays showed that circ_0017956 promotes malignant NSCLC phenotypes, including proliferation, migration, invasion, angiogenesis and in vivo tumor growth, while suppressing apoptosis. Mechanistically, cytoplasmic circ_0017956 acts as a sponge for miR-758-3p to increase FOXP4 expression, forming a circ_0017956/miR-758-3p/FOXP4 regulatory axis."	0.8175
36764873	Clinical breast cancer	2023	Circ_0108942 Regulates the Progression of Breast Cancer by Regulating the MiR-1178-3p/TMED3 Axis.	hsa_circ_0108942	Circ_0108942	hsa_circ_ANKRD12	ANKRD12	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"Circ_0108942 is up-regulated in breast cancer tissues and cell lines. It promotes breast cancer progression by sponging miR-1178-3p and upregulating TMED3, enhancing proliferation, migration, invasion, angiogenic tube formation and tumor growth while suppressing apoptosis. The study suggests circ_0108942 may be a potential diagnostic, prognostic or therapeutic target for breast cancer."	0.8005
36773765	Transplant immunology	2023	Comprehensive analysis of circular RNA-associated competing endogenous RNA networks and immune infiltration in gastric cancer.	hsa_circ_0002504				gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR; Microarray	"hsa_circ_0002504 was down-regulated in gastric cancer datasets and cell lines and was experimentally validated by qRT-PCR. Its overexpression reduced migration and invasion of AGS and HGC-27 cells, possibly through a ceRNA mechanism involving hsa-miR-615-5p/hsa-miR-767-5p and EPHA4, KCNA1, and NCAM1. The study proposes hsa_circ_0002504 as a potential diagnostic biomarker and therapeutic target for GC."	0.4852
36773765	Transplant immunology	2023	Comprehensive analysis of circular RNA-associated competing endogenous RNA networks and immune infiltration in gastric cancer.	hsa_circ_0001998				gastric cancer / GC	MONDO:0001056	gastric cancer	dysregulated	Microarray	"hsa_circ_0001998 was identified as one of two differentially expressed circRNAs in the gastric cancer ceRNA network based on GEO microarray and bioinformatics analyses. The study predicted that hsa_circ_0001998 may act as a hsa-miR-490-5p sponge and regulate downstream target genes such as EPHA4 and KCNA1, but no positive RT-qPCR or functional validation was reported for this circRNA."	0.1768
36775059	Translational research : the journal of laboratory and clinical medicine	2023	The circular RNA circHelz enhances cardiac fibrosis by facilitating the nuclear translocation of YAP1.	mmu_circ_0000332	circHelz	mmu_circ_Helz	Helz	cardiac fibrosis	MONDO:0004994	cardiomyopathy	up-regulated	RT-qPCR	"circHelz is a mouse Helz-derived circRNA upregulated in cardiac fibrotic tissue and activated cardiac fibroblasts. NFATc2 promotes circHelz expression, and circHelz binds YAP1 to facilitate its nuclear translocation, thereby promoting fibroblast activation, proliferation, migration, collagen deposition and cardiac fibrosis. Silencing circHelz alleviates MI- and AngII-induced cardiac fibrosis in mice, suggesting a potential therapeutic target."	0.842
36777845	American journal of translational research	2023	Expression profiling of circular RNA reveals a potential miR-145-5p sponge function of circ-AFF2 and circ-ASAP1 in renal cell carcinoma.	hsa_circ_0001947	circ-AFF2	hsa_circ_AFF2	AFF2	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ-AFF2 is up-regulated in RCC tissues and functions as an oncogenic circRNA. It promotes RCC cell proliferation, likely through a ceRNA mechanism in which it sponges miR-145-5p and supports expression of downstream proliferation-related genes; high expression is associated with poor prognosis and diagnostic potential."	0.8499
36777845	American journal of translational research	2023	Expression profiling of circular RNA reveals a potential miR-145-5p sponge function of circ-AFF2 and circ-ASAP1 in renal cell carcinoma.	hsa_circ_0008934	circ-ASAP1	hsa_circ_ASAP1	ASAP1	renal cell carcinoma / RCC	MONDO:0005086	renal cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circ-ASAP1 is up-regulated in RCC tissues and acts as an oncogenic circRNA. It promotes RCC cell proliferation by sponging miR-145-5p and modulating downstream proliferation-related genes; its high expression is associated with poor prognosis, although its ROC result suggests weaker diagnostic performance than circ-AFF2."	0.8499
36777857	American journal of translational research	2023	CircRNA_0263 and circRNA_1507 are dysregulated in a rat model of atrial fibrosis induced by chronic intermittent hypoxia.		circRNA_0263			atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	up-regulated	RT-qPCR; RNA-seq	circRNA_0263 was identified as the most upregulated circRNA in atrial tissue from CIH-induced atrial fibrosis model rats and was validated by qRT-PCR. The study predicts that circRNA_0263 participates in AF/atrial fibrosis progression through a ceRNA mechanism involving miR-29b-5p/3p and other miRNAs.	0.4375
36777857	American journal of translational research	2023	CircRNA_0263 and circRNA_1507 are dysregulated in a rat model of atrial fibrosis induced by chronic intermittent hypoxia.		circRNA_1507			atrial fibrillation / AF	MONDO:0004981	atrial fibrillation	down-regulated	RT-qPCR; RNA-seq	"circRNA_1507 was identified as the most downregulated circRNA in atrial tissue from CIH-induced atrial fibrosis model rats and was validated by qRT-PCR. The study predicts that circRNA_1507 participates in a ceRNA network by sponging miRNAs such as rno-miR-136-5p, rno-miR-496-3p, and rno-miR-337-3p, potentially regulating target genes including Smim6, Gfra4, Sp6, and Efnb3."	0.4375
36780058	Molecular biotechnology	2023	Circ_0124208 Promotes the Progression of Hepatocellular Carcinoma by Regulating the miR-338-3p/LAMC1 Axis.	hsa_circ_0124208	circ_0124208	hsa_circ_TKT	TKT	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0124208 is up-regulated in HCC tissues and cell lines and acts as an oncogenic circRNA. Functionally, circ_0124208 promotes proliferation, migration, colony formation and xenograft tumor growth while inhibiting apoptosis. Mechanistically, it sponges miR-338-3p to upregulate LAMC1, suggesting potential diagnostic biomarker and therapeutic target value in HCC."	0.7795
36780172	Biology of reproduction	2023	Circ_0115118 regulates endometrial functions through the miR-138-1-3p/WDFY2 axis in patients with PCOS_.	hsa_circ_0115118	circ_0115118	hsa_circ_SAMHD1	SAMHD1	polycystic ovary syndrome / PCOS	MONDO:0008487	polycystic ovary syndrome	up-regulated	RT-qPCR; Microarray	"circ_0115118 is upregulated in endometrial stromal cells from patients with PCOS, especially in the proliferative phase. Its overexpression suppresses stromal cell proliferation, migration and invasion, disrupts decidualization-related function, and reduces embryo implantation, acting through the miR-138-1-3p/WDFY2 axis with reduced AKT phosphorylation. The study suggests circ_0115118 as a potential therapeutic target for improving pregnancy outcomes in women with PCOS."	0.8058
36781583	Metabolic brain disease	2023	Circ_0000566 contributes oxygen-glucose deprivation and reoxygenation (OGD/R)-induced human brain microvascular endothelial cell injury via regulating miR-18a-5p/ACVR2B axis.	hsa_circ_0000566	circ_0000566	hsa_circ_VRK1	VRK1	ischemic stroke / IS	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR	"circ_0000566 is up-regulated in OGD/R-treated human brain microvascular endothelial cells and promotes OGD/R-induced endothelial cell injury. Mechanistically, circ_0000566 sponges miR-18a-5p to regulate ACVR2B expression, thereby contributing to reduced cell viability and increased apoptosis and inflammation in the in vitro ischemic stroke injury model."	0.7615
36786410	Clinical and experimental pharmacology & physiology	2023	CircADSS contributes to hepatocellular carcinoma development by regulating miR-431-5p/TOP2A.			hsa_circ_ADSS	ADSS	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circADSS is up-regulated in HCC tumour tissues and cell lines. Functionally, circADSS promotes HCC cell proliferation, cell cycle progression, migration, invasion, EMT, and xenograft tumour growth. Mechanistically, it acts through a circADSS/miR-431-5p/TOP2A regulatory axis."	0.8169
36787831	Translational research : the journal of laboratory and clinical medicine	2023	CircFOXP1 alleviates brain injury after acute ischemic stroke by regulating STAT3/apoptotic signaling.		circFOXP1	hsa_circ_FOXP1	FOXP1	ischemic stroke / IS	MONDO:1060198	ischemic stroke	down-regulated	RT-qPCR	"circFOXP1 is down-regulated in peripheral blood from AIS patients and its higher expression is linked to milder disease and better prognosis. Functionally, circFOXP1 protects against ischemic/hypoxic injury by binding STAT3, reducing STAT3 ubiquitination and degradation, and suppressing apoptotic signaling; QKI promotes circFOXP1 biogenesis under these conditions."	0.8999
36790665	Biochemical genetics	2023	The Circular RNA Circ_0085494 Regulates Prostate Cancer Progression Through NRBP1/miR-497-5p Axis.	hsa_circ_0085494	Circ_0085494	hsa_circ_TMEM65	TMEM65	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circ_0085494 is up-regulated in prostate cancer tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation, migration, invasion, EMT-related changes, and xenograft tumor growth by sponging miR-497-5p and increasing NRBP1 expression. Clinically, higher circ_0085494 expression is associated with advanced disease features and poorer prognosis."	0.8281
36796622	Neuroscience letters	2023	"circPKD2 inhibits the glioma cell proliferation, invasion and glycolytic metabolism through regulating the miR-1278/LATS2 axis."	hsa_circ_0070401	circPKD2 / circ_0070401	hsa_circ_PKD2	PKD2	glioma	MONDO:0021042	glioma	down-regulated	RT-qPCR; Microarray	"circPKD2 is down-regulated in glioma tissues and cells, and higher circPKD2 expression is associated with better patient outcome. Functionally, circPKD2 suppresses glioma proliferation, invasion, glycolytic metabolism, and xenograft tumor growth. Mechanistically, it acts as a miR-1278 sponge to increase LATS2 expression, forming a circPKD2/miR-1278/LATS2 tumor-suppressive axis."	0.8066
36796652	Brain research bulletin	2023	Hypoxic glioma cell-secreted exosomal circ101491 promotes the progression of glioma by regulating miR-125b-5p/EDN1.		circ101491			glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; Microarray	"circ101491 is up-regulated in glioma tissues, patient plasma exosomes, and hypoxic glioma cell-derived exosomes. It promotes glioma cell viability, invasion, migration, tumor growth and metastasis, at least partly through an exosome-associated circ101491/miR-125b-5p/EDN1 ceRNA axis. Its high expression is associated with tumor differentiation, TNM staging and poor prognosis."	0.8634
36796652	Brain research bulletin	2023	Hypoxic glioma cell-secreted exosomal circ101491 promotes the progression of glioma by regulating miR-125b-5p/EDN1.		circ048977			glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; Microarray	"circ048977 was identified by circRNA microarray screening and validated by qRT-PCR as highly expressed in hypoxic glioma cell-derived exosomes. The study did not report downstream mechanisms, functional assays, or clinical significance for circ048977."	0.1904
36796652	Brain research bulletin	2023	Hypoxic glioma cell-secreted exosomal circ101491 promotes the progression of glioma by regulating miR-125b-5p/EDN1.		circ404935			glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; Microarray	"circ404935 was identified by circRNA microarray screening and validated by qRT-PCR as highly expressed in hypoxic glioma cell-derived exosomes. The study did not report downstream mechanisms, functional assays, or clinical significance for circ404935."	0.1904
36799424	Current molecular pharmacology	2024	Hsa_Circ_0000021 Sponges miR-3940-3p/KPNA2 Expression to Promote Cervical Cancer Progression.	hsa_circ_0000021	circ_0000021	hsa_circ_PLEKHM2	PLEKHM2	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"hsa_circ_0000021 is up-regulated in cervical cancer tissues and cell lines and mainly localizes to the cytoplasm. It promotes CC cell proliferation, invasion, migration, and xenograft tumor growth by sponging miR-3940-3p and regulating the downstream target KPNA2, suggesting potential value as a therapeutic target."	0.7799
36801359	Brain research bulletin	2023	CircSYNDIG1 ameliorates stress-induced abnormal behaviors by suppressing miR-344-5p in mice.		mmu_circRNA_34764	mmu_circ_SYNDIG1	SYNDIG1	stress-related neuropsychiatric disorders 	MONDO:0002050	depressive disorder	down-regulated	RT-qPCR; Microarray	"circSYNDIG1 is down-regulated in the hippocampus of stressed mice and is negatively associated with depressive- and anxiety-like behaviors. Restoring circSYNDIG1 expression protects against CUMS- or miR-344-5p-induced behavioral abnormalities, memory impairment, dendritic spine density loss, and reduced cell viability, mainly by sponging miR-344-5p."	0.6731
36801359	Brain research bulletin	2023	CircSYNDIG1 ameliorates stress-induced abnormal behaviors by suppressing miR-344-5p in mice.		mmu_circRNA_006216	mmu_circ_DTNB	DTNB	stress-related neuropsychiatric disorders 	MONDO:0002050	depressive disorder	down-regulated	RT-qPCR; Microarray	"circDTNB was identified by microarray and validated by qRT-PCR as a down-regulated circRNA in the hippocampus of CUMS mice. Its expression was negatively correlated with latency to feeding in the NSF test, but the paper did not pursue mechanistic or functional studies of circDTNB."	0.4851
36807271	Molecular biotechnology	2023	Hsa_circ_0137652 Regulates miR-1205/CCNB1 Axis to Accelerate the Malignancy of Breast Cancer.	hsa_circ_0137652	circ_0137652	hsa_circ_RAD23B	RAD23B	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0137652 is upregulated in breast cancer tissues and cell lines and is mainly localized in the cytoplasm. It promotes breast cancer malignancy by sponging miR-1205 and regulating the downstream CCNB1 axis, thereby enhancing proliferation, clone formation, migration, and xenograft tumor growth. The study suggests circ_0137652 may serve as a potential biomarker and therapeutic target for breast cancer."	0.7893
36808266	Biochemical genetics	2023	Circ_0001715 Functions as a miR-1249-3p Sponge to Accelerate the Progression of Non-small Cell Lung Cancer via Upregulating the Level of FGF5.	hsa_circ_0001715	Circ_0001715	hsa_circ_LIMK1	LIMK1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circ_0001715 is up-regulated in NSCLC tissues and cell lines and acts as an oncogenic circRNA. It promotes proliferation, migration, invasion and xenograft tumor progression while inhibiting apoptosis by sponging miR-1249-3p and increasing FGF5 expression. The study suggests circ_0001715 may serve as a potential diagnostic or therapeutic target in NSCLC."	0.8175
36809521	Clinical and experimental pharmacology & physiology	2023	Hsa_circ_0000591 drives osteosarcoma glycolysis and progression by sequestering miR-194-5p and elevating HK2 expression.	hsa_circ_0000591	hsa_circRNA_101488			osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000591/circ_0000591 is up-regulated in osteosarcoma tissues and cell lines, and high expression is associated with shorter overall survival. Functionally, it promotes OS proliferation, invasion, glycolysis, and xenograft growth while suppressing apoptosis. Mechanistically, circ_0000591 acts as a cytoplasmic miR-194-5p sponge to elevate HK2 expression, thereby driving OS progression and glycolysis."	0.8497
36810972	Cell stress & chaperones	2023	"CircHSPG2 knockdown attenuates hypoxia-induced apoptosis, inflammation, and oxidative stress in human AC16 cardiomyocytes by regulating the miR-1184/MAP3K2 axis."	hsa_circ_0010551	circRNA heparan sulfate proteoglycan 2	hsa_circ_HSPG2	HSPG2	acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR	"circHSPG2 is up-regulated in AMI patient serum and hypoxia-treated human AC16 cardiomyocytes. Its knockdown protects AC16 cells from hypoxia-induced injury by sponging miR-1184 and reducing MAP3K2 expression, thereby attenuating apoptosis, inflammation, and oxidative stress while improving cell viability and glycolysis."	0.8275
36826778	"Hormones (Athens, Greece)"	2023	CircRTN1 stimulates HMGB1 to regulate the malignant progression of papillary thyroid cancer by sponging miR-101-3p.	hsa_circ_0102272	CircRTN1	hsa_circ_RTN1	RTN1	papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"In papillary thyroid cancer, circRTN1 is up-regulated in tumor tissues and PTC cell lines and mainly localizes to the cytoplasm. It promotes malignant progression by sponging miR-101-3p, thereby increasing HMGB1 expression and enhancing proliferation, migration, invasion, metastasis-related phenotypes, and xenograft tumor growth. Clinically, its expression was reported to associate with TNM stage, lymph node metastasis, and tumor size, suggesting potential therapeutic relevance of the circRTN1/miR-101-3p/HMGB1 axis."	0.8443
36827915	International immunopharmacology	2023	Autophagy-mediated circHIPK2 promotes lipopolysaccharide-induced astrocytic inflammation via SIGMAR1.	mmu_circ_0001468 		mmu_circ_HIPK2	HIPK2	astrocytic inflammation	MONDO:0005156	encephalomyelitis	up-regulated	RT-qPCR	"This study shows that mouse circHIPK2 is up-regulated in LPS-induced astrocytic inflammation in vivo and in primary astrocytes. circHIPK2 promotes astrocyte activation and inflammatory responses through the SIGMAR1 axis, while rapamycin-induced autophagy suppresses circHIPK2 expression and attenuates the inflammatory phenotype."	0.5074
36828974	Human cell	2023	CircRNA_0017076 acts as a sponge for miR-185-5p in the control of epithelial-to-mesenchymal transition of tubular epithelial cells during renal interstitial fibrosis.	hsa_circ_0017076		hsa_circ_GNG4	GNG4	renal interstitial fibrosis	MONDO:0000494	renal fibrosis	up-regulated	RT-qPCR; ISH	"hsa_circ_0017076/CircRNA_0017076 is up-regulated in human RIF kidney biopsies and TGF-beta1-treated HK-2 cells. It functions as a cytoplasmic miR-185-5p sponge to increase STIM1 expression, enhance Ca2+ influx, activate CaMKII/ERK/FAK signaling, and promote EMT and renal fibrosis, suggesting potential biomarker and therapeutic relevance."	0.8414
36828974	Human cell	2023	CircRNA_0017076 acts as a sponge for miR-185-5p in the control of epithelial-to-mesenchymal transition of tubular epithelial cells during renal interstitial fibrosis.	mmu_circ_0004488		mmu_circ_Gng4	Gng4	renal interstitial fibrosis	MONDO:0000494	renal fibrosis	up-regulated	RT-qPCR	"mmu_circ_0004488 is the mouse homologous circRNA of hsa_circ_0017076 and is up-regulated in UUO-induced renal fibrosis. AAV-mediated silencing of mmu_circ_0004488 in mouse kidneys reduces fibrotic lesions and downregulates Stim1 and fibrosis/EMT markers, consistent with regulation through the miR-185-5p/Stim1 axis."	0.5358
36840697	Environmental toxicology	2023	CircRNA circSTIL inhibits ferroptosis in colorectal cancer via miR-431/SLC7A11 axis.		circSTIL	hsa_circ_STIL	STIL	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circSTIL is upregulated in colorectal cancer tissues and cell lines, and high expression is associated with poor prognosis. Functionally, circSTIL promotes CRC cell proliferation and inhibits ferroptosis. Mechanistically, circSTIL acts as a ceRNA for miR-431 to positively regulate SLC7A11 expression, forming a circSTIL-miR-431-SLC7A11 axis that contributes to CRC progression."	0.7618
36840847	Molecular neurobiology	2023	Circular RNAs in Parkinson's Disease: Reliable Biological Markers and Targets for Rehabilitation.	hsa_circ_0001535	circFAM13B	hsa_circ_FAM13B	FAM13B	Parkinson's disease / PD	MONDO:0005180	Parkinson disease	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0001535/circFAM13B is up-regulated in peripheral blood exosomes from PD patients and decreases after rehabilitation. The study proposes that it may be linked to alpha-synuclein aggregation, actin backbone stability, small GTPase-mediated signaling, and P53-related pathological processes, making it a potential biomarker and rehabilitation target."	0.4032
36840847	Molecular neurobiology	2023	Circular RNAs in Parkinson's Disease: Reliable Biological Markers and Targets for Rehabilitation.	hsa_circ_0000437	circCORO1C	hsa_circ_CORO1C	CORO1C	Parkinson's disease / PD	MONDO:0005180	Parkinson disease	up-regulated	RT-qPCR; RNA-seq	hsa_circ_0000437/circCORO1C is up-regulated in peripheral blood exosomes from PD patients and decreases after rehabilitation. The study suggests that it may promote inflammatory responses in PD by sponging hsa-let-7b-5p and hsa-let-7c-5p and may be connected to NF-kappaB-related inflammatory signaling.	0.4032
36843004	"Clinical and experimental hypertension (New York, N.Y. : 1993)"	2023	Association of Circular RNAs levels in blood and Essential Hypertension with Carotid Plaque.	hsa_circ_0124782				essential hypertension / EH	MONDO:0001134	essential hypertension	up-regulated	RT-qPCR; Microarray	"hsa_circ_0124782 was up-regulated in blood from EH and EH with carotid plaque groups compared with controls. Its high expression was an independent risk factor and potential biomarker for EH with carotid plaque, and the authors predicted a ceRNA-type hsa_circ_0124782/hsa-miR-1179/mRNA regulatory mechanism."	0.5047
36843004	"Clinical and experimental hypertension (New York, N.Y. : 1993)"	2023	Association of Circular RNAs levels in blood and Essential Hypertension with Carotid Plaque.	hsa_circ_0131618				essential hypertension / EH	MONDO:0001134	essential hypertension	down-regulated	RT-qPCR; Microarray	"hsa_circ_0131618 was down-regulated in blood from EH and EH with carotid plaque groups compared with controls. Low expression was an independent risk factor and potential biomarker for EH with carotid plaque, and the authors predicted a ceRNA-type hsa_circ_0131618/hsa-miR -627-3p/mRNA regulatory mechanism."	0.5047
36843004	"Clinical and experimental hypertension (New York, N.Y. : 1993)"	2023	Association of Circular RNAs levels in blood and Essential Hypertension with Carotid Plaque.	hsa_circ_0127342				essential hypertension / EH	MONDO:0001134	essential hypertension	down-regulated	RT-qPCR; Microarray	"hsa_circ_0127342 was down-regulated in blood from EH and EH with carotid plaque groups compared with controls, and differed significantly between EH and EH with carotid plaque groups. Low hsa_circ_0127342 was an independent risk factor and potential biomarker for EH with carotid plaque, with predicted ceRNA interactions involving hsa-miR-136-5p, hsa-miR-153-5p and hsa-miR-197-3p."	0.5047
36852950	Histology and histopathology	2023	Hsa_circ_0070440 promotes lung adenocarcinoma progression by SLC7A11-mediated-ferroptosis.	hsa_circ_0070440		hsa_circ_FAM13A	FAM13A	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"hsa_circ_0070440 is up-regulated in LUAD tissues and cells. It promotes LUAD cell proliferation and tumor growth while inhibiting apoptosis and ferroptosis, at least partly by sponging miR-485-5p to upregulate SLC7A11 and downstream molecules such as c-myc and bcl-xl. The circ_0070440/miR-485-5p/SLC7A11 axis is proposed as a potential biomarker axis for clinical detection in LUAD."	0.8571
36853491	Journal of endocrinological investigation	2023	CircOMA1 modulates cabergoline resistance by downregulating ferroptosis in prolactinoma.		circOMA1	hsa_circ_OMA1		prolactinoma	MONDO:0010911	prolactin-producing pituitary gland adenoma	up-regulated	RT-qPCR	"circOMA1 is up-regulated in DA-resistant prolactinoma tissues and promotes prolactinoma cell growth in vitro and in a xenograft model. Mechanistically, circOMA1 acts as a miR-145-5p sponge to regulate GCLM and promotes the Nrf2/GPX4 ferroptosis-resistance program, thereby attenuating cabergoline-induced ferroptosis and reducing cabergoline efficacy."	0.713
36856209	Nan fang yi ke da xue xue bao = Journal of Southern Medical University	2023	[Circular RNA circRSF1 binds to HuR to promote radiation-induced inflammatory phenotype in hepatic stellate cells].	hsa_circ_0023706		hsa_circ_RSF1	RSF1	radiation-induced liver disease	MONDO:0043459	radiation-induced disorder	up-regulated	RT-qPCR	"In irradiated human hepatic stellate cells, circRSF1 is up-regulated and promotes an inflammatory phenotype. Mechanistically, circRSF1 binds the RNA-binding protein HuR, reduces HuR binding to IkappaBalpha mRNA, down-regulates IkappaBalpha, and activates the NF-kappaB pathway, leading to increased IL-1beta, IL-6 and TNF-alpha production."	0.5802
36856372	Histology and histopathology	2023	Has_circ_0071803 promotes colorectal cancer progression by regulating miR-330-5p/MAPK signaling pathway.	hsa_circ_0071803				colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circ_0071803 is upregulated in colorectal cancer tissues and cell lines, and higher expression is associated with poorer survival. Functionally, circ_0071803 promotes CRC cell proliferation, migration, and invasion by sponging miR-330-5p to increase MAPK1 expression and activate MAPK signaling, suggesting its potential as a therapeutic target."	0.7646
36857620	Acta biochimica Polonica	2023	Silencing circCAMSAP1 suppresses malignant behavior of endometrial cancer by targeting microRNA-370-3p/MAPK1.	hsa_circ_0004338		hsa_circ_CAMSAP1	CAMSAP1	endometrial cancer / EC	MONDO:0011962	endometrial cancer	up-regulated	RT-qPCR	"circCAMSAP1 is up-regulated in endometrial cancer tissues and cell lines. It promotes malignant phenotypes of EC cells, including proliferation, migration and invasion, while inhibiting apoptosis, and functions through the miR-370-3p/MAPK1 regulatory axis. Silencing circCAMSAP1 suppresses EC cell malignant behavior and may provide a diagnostic or therapeutic marker axis."	0.7045
36858188	Gene	2023	Tumor suppressor circPDE4D inhibits the progression of colorectal cancer and regulates oxaliplatin chemoresistance.	hsa_circ_0072568		hsa_circ_PDE4D	PDE4D	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"CircPDE4D is a PDE4D-derived human circRNA that is downregulated in CRC cells and tissues. It functions as a tumor suppressor by inhibiting CRC cell proliferation, migration and invasion and promoting apoptosis, and it also suppresses malignant phenotypes in oxaliplatin-resistant CRC cells. Mechanistically, the study suggests that circPDE4D may regulate the hsa-miR-569/SPI1 axis and may serve as a therapeutic target for CRC and chemoresistant CRC."	0.6903
36867268	Functional & integrative genomics	2023	"circGRAMD1B contributes to migration, invasion and epithelial-mesenchymal transition of lung adenocarcinoma cells via modulating the expression of SOX4."		circGRAMD1B	hsa_circ_GRAMD1B	GRAMD1B	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circGRAMD1B is up-regulated in LUAD cells and functions as an oncogenic circRNA that promotes LUAD cell migration, invasion, and EMT. Mechanistically, cytoplasmic circGRAMD1B sponges miR-4428 to increase SOX4 expression, leading to SOX4-mediated transcriptional activation of MEX3A and activation of the PI3K/AKT pathway."	0.7986
36867300	Metabolic brain disease	2023	CircRNA-104718 promotes glioma malignancy through regulation of miR-218-5p/HMGB1 signalling pathway.	hsa_circ_0085803	CircRNA-104718			glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"CircRNA-104718/hsa_circ_0085803 is upregulated in human glioma and high expression is associated with poorer survival. Functionally, silencing circRNA-104718 suppresses glioma cell proliferation, migration, invasion, metastasis-related behavior and xenograft tumour growth while promoting apoptosis. Mechanistically, the study supports a ceRNA-like circRNA-104718/miR-218-5p/HMGB1 regulatory axis."	0.7376
36869127	Oncogene	2023	Regulation of CD8+ T cells infiltration and immunotherapy by circMGA/HNRNPL complex in bladder cancer.	hsa_circ_0000591	circMGA	hsa_circ_MGA	MGA	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	down-regulated	RT-qPCR; RNA-seq	"circMGA is a human MGA-derived circRNA that is downregulated in bladder cancer and whose higher expression is associated with favorable overall survival. It acts as a cytoplasmic tumor suppressor by binding HNRNPL, stabilizing CCL5 mRNA, increasing CCL5 secretion, recruiting CD8+ T cells, and enhancing anti-PD-1 immunotherapy efficacy."	0.8981
36870073	"Shock (Augusta, Ga.)"	2023	CIRC_0012535 CONTRIBUTES TO LIPOPOLYSACCHARIDE-INDUCED FETAL LUNG FIBROBLAST APOPTOSIS AND INFLAMMATION TO REGULATE INFANTILE PNEUMONIA DEVELOPMENT BY MODULATING THE MIR-338-3P/IL6R SIGNALING.	hsa_circ_0012535	circ_0012535	hsa_circ_TUT4	TUT4	infantile pneumonia / IP	MONDO:0005249	pneumonia	up-regulated	RT-qPCR; Microarray	"circ_0012535 is up-regulated in LPS-treated human fetal lung fibroblasts and was identified as highly expressed in blood samples from community-acquired pneumonia patients. Functionally, circ_0012535 promotes LPS-induced apoptosis, inflammation, oxidative stress and cell growth impairment. Mechanistically, circ_0012535 acts as a ceRNA that sponges miR-338-3p to increase IL6R expression."	0.7922
36881338	Functional & integrative genomics	2023	CircAGO2 promotes colorectal cancer progression by inhibiting heat shock protein family B (small) member 8 via miR-1-3p/retinoblastoma binding protein 4 axis.	hsa_circ_0135889		hsa_circ_AGO2	AGO2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"CircAGO2 is upregulated in colorectal cancer tissues and cell lines and is associated with advanced TNM stage and poorer overall survival. Functionally, circAGO2 promotes CRC cell proliferation, invasion, xenograft tumor growth, and micro-angiogenesis. Mechanistically, circAGO2 sponges miR-1-3p to increase RBBP4 expression, leading to reduced HSPB8 transcription through H3K27ac-related histone deacetylation."	0.7941
36881359	Advances in clinical and experimental medicine : official organ Wroclaw Medical University	2023	Hsa-circ-0000098 promotes the progression of hepatocellular carcinoma by regulation of miR-136-5p/MMP2 axis.	hsa_circ_0000098				hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000098 is up-regulated in HCC tissues and cell lines, and high expression is associated with worse prognosis and aggressive clinicopathological features. Functionally, it promotes HCC cell migration, invasion, metastasis and malignant progression by acting as a cytoplasmic ceRNA that sponges miR-136-5p and regulates MMP2."	0.814
36883376	Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism	2023	RNA profiling of sEV (small extracellular vesicles)/exosomes reveals biomarkers and vascular endothelial dysplasia with moyamoya disease.	hsa_circ_0000583				moyamoya disease / MMD	MONDO:0016820	Moyamoya disease	dysregulated	RT-qPCR; Microarray	"hsa_circRNA_0000583 was differentially expressed in serum-derived sEV/exosomes from MMD/ICAD patients versus controls and was functionally tested in HBMECs. Its knockdown reduced endothelial cell viability, proliferation, and tube formation and increased apoptosis, supporting a role in vascular endothelial dysfunction relevant to MMD."	0.6093
36883376	Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism	2023	RNA profiling of sEV (small extracellular vesicles)/exosomes reveals biomarkers and vascular endothelial dysplasia with moyamoya disease.	hsa_circ_0090577				moyamoya disease / MMD	MONDO:0016820	Moyamoya disease	dysregulated	RT-qPCR; Microarray	"hsa_circRNA_0090577 was differentially expressed in serum-derived sEV/exosomes from MMD/ICAD patients versus controls and was selected for functional testing in HBMECs. Knockdown inhibited endothelial proliferation and tube formation and increased apoptosis, indicating a potential role in vascular endothelial dysplasia in MMD."	0.6093
36883376	Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism	2023	RNA profiling of sEV (small extracellular vesicles)/exosomes reveals biomarkers and vascular endothelial dysplasia with moyamoya disease.	hsa_circ_0051937				moyamoya disease / MMD	MONDO:0016820	Moyamoya disease	dysregulated	RT-qPCR; Microarray	"hsa_circRNA_0051937 was differentially expressed in serum-derived sEV/exosomes from MMD/ICAD patients and was evaluated in HBMECs. Knockdown suppressed endothelial viability, proliferation, and tube formation while increasing apoptosis, suggesting involvement in vascular endothelial dysplasia associated with MMD."	0.6093
36883376	Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism	2023	RNA profiling of sEV (small extracellular vesicles)/exosomes reveals biomarkers and vascular endothelial dysplasia with moyamoya disease.	hsa_circ_0076043				moyamoya disease / MMD	MONDO:0016820	Moyamoya disease	dysregulated	RT-qPCR; Microarray	"hsa_circRNA_0076043 was one of six exosomal circRNA candidates selected from whole-transcriptome profiling and validated by PCR as differentially expressed in SDEs from MMD/ICAD patients. The study proposed that such dysregulated exosomal RNAs may serve as biological markers, but no direct functional mechanism was reported for this circRNA."	0.4032
36883376	Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism	2023	RNA profiling of sEV (small extracellular vesicles)/exosomes reveals biomarkers and vascular endothelial dysplasia with moyamoya disease.	hsa_circ_0074463				moyamoya disease / MMD	MONDO:0016820	Moyamoya disease	dysregulated	RT-qPCR; Microarray	"hsa_circRNA_0074463 was selected as a candidate exosomal circRNA and validated by PCR as differentially expressed in SDEs from MMD/ICAD patients. The article suggests possible biomarker relevance, but does not report circRNA-specific functional assays or molecular targets for this candidate."	0.4032
36883376	Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism	2023	RNA profiling of sEV (small extracellular vesicles)/exosomes reveals biomarkers and vascular endothelial dysplasia with moyamoya disease.	hsa_circ_0001491				moyamoya disease / MMD	MONDO:0016820	Moyamoya disease	dysregulated	RT-qPCR; Microarray	"hsa_circRNA_0001491 was among the six candidate exosomal circRNAs identified from RNA profiling and validated by PCR as differentially expressed in patient SDEs. The study links this differential expression to possible biomarker value in MMD/ICAD, but does not provide a specific mechanistic or functional assay for this circRNA."	0.4032
36884165	Biochemical genetics	2023	Circ-FNDC3B Functions as an Oncogenic Factor in Esophageal Squamous Cell Carcinoma via Upregulating MYO5A by Absorbing miR-136-5p and miR-370-3p.	hsa_circ_0001361	circRNA fibronectin type III domain-containing protein 3B / hsa_circRNA_103512	hsa_circ_FNDC3B	FNDC3B	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"Circ-FNDC3B is upregulated in ESCC tissues and cells and functions as an oncogenic circRNA. It promotes ESCC proliferation, invasion, metastasis-related phenotypes and xenograft tumor growth while suppressing apoptosis by sponging miR-136-5p and miR-370-3p to increase MYO5A expression. High circ-FNDC3B expression is associated with adverse clinicopathologic features and poorer overall survival."	0.7892
36889763	Annals of clinical and laboratory science	2023	CircCCNB1 Knockdown Blocks the Progression of Cervical Cancer by Acting as Competing Endogenous RNA in the miR-370-3p/SOX4 Pathway.	hsa_circ_0001495	circRNA cyclin B1 / circCCNB1	hsa_circ_CCNB1	CCNB1	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"CircCCNB1 is up-regulated in cervical cancer tissues and cell lines and is higher in advanced-stage tumors. Functionally, circCCNB1 promotes proliferation, migration, invasion, glycolysis and xenograft tumor growth while suppressing apoptosis. Mechanistically, it acts as a ceRNA sponge for miR-370-3p to increase SOX4 expression, supporting its role as an oncogenic circRNA and potential therapeutic target."	0.8438
36892025	Protein and peptide letters	2023	circ_0006089 Facilitates Gastric Cancer Progression via Decoying miR- 515-5p and Up-regulating CXCL6.	hsa_circ_0006089		hsa_circ_ASAP2	ASAP2	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circ_0006089 is up-regulated in gastric cancer tissues and cell lines and acts as an oncogenic circRNA. It promotes GC cell proliferation, migration and invasion by sponging miR-515-5p and increasing CXCL6 expression, suggesting potential value as a biomarker and therapeutic target."	0.7618
36892682	Applied biochemistry and biotechnology	2023	"Circ-C16orf62 Regulates Oxidized low-density Lipoprotein-induced Apoptosis, Inflammation, Oxidative Stress and Cholesterol Accumulation of Macrophages via Mediating RAB22A Expression by Targeting miR-377."	hsa_circ_0003645		hsa_circ_C16orf62	C16orf62	Atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"circ-C16orf62 is up-regulated in AS patient serum and ox-LDL-treated THP-1 macrophages. It promotes ox-LDL-induced macrophage injury by acting as a ceRNA for miR-377, thereby increasing RAB22A expression and activating NF-kappaB-related inflammatory signaling. Knockdown of circ-C16orf62 alleviates apoptosis, inflammation, oxidative stress and cholesterol accumulation, suggesting a potential therapeutic role in AS."	0.7795
36895988	American journal of cancer research	2023	EIF4A3 induced circABCA5 promotes the gastric cancer progression by SPI1 mediated IL6/JAK2/STAT3 signaling.	hsa_circ_0107595		hsa_circ_ABCA5	ABCA5	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"circABCA5/hsa_circ_0107595 is upregulated in gastric cancer tissues and high expression is associated with shorter patient survival. Functionally, circABCA5 promotes gastric cancer cell proliferation, invasion, migration, and xenograft growth. Mechanistically, EIF4A3 stabilizes circABCA5, while circABCA5 binds and upregulates SPI1, promoting SPI1 nuclear translocation and activation of IL6/JAK2/STAT3 signaling."	0.8967
36905137	Vascular	2024	Circ_0000595 knockdown alleviates CoCl2-mediated effects in VSMCs by regulating the miR-582-3p/ADAM10 axis.	hsa_circ_0000595		hsa_circ_CASC4	CASC4	Thoracic aortic aneurysm / TAA	MONDO:0005396	thoracic aortic aneurysm	up-regulated	RT-qPCR	"circ_0000595 is upregulated in TAA aortic tissues and CoCl2-induced hypoxic VSMCs. It acts as a ceRNA sponge for miR-582-3p to promote ADAM10 expression, thereby suppressing VSMC proliferation and promoting apoptosis; circ_0000595 knockdown alleviates these CoCl2-mediated effects."	0.8111
36905560	Metabolic brain disease	2023	Circular RNA circ_0000741/miR-379-5p/TRIM14 signaling axis promotes HDAC inhibitor (SAHA) tolerance in glioblastoma.	hsa_circ_0000741				glioblastoma / GBM	MONDO:0018177	glioblastoma	up-regulated	RT-qPCR; Microarray	"circ_0000741 is up-regulated in GBM and further elevated in SAHA-tolerant GBM cells. It promotes SAHA tolerance and malignant phenotypes by acting as a ceRNA for miR-379-5p to regulate TRIM14, while circ_0000741 knockdown sensitizes GBM cells to SAHA in vitro and in a xenograft model."	0.8175
36913084	Molecular biotechnology	2023	Hsa_circ_0084912 Drives the Progression of Cervical Cancer Via Regulating miR-429/SOX2 Pathway.	hsa_circ_0084912		hsa_circ_KIAA1429	KIAA1429	Cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"Hsa_circ_0084912 is upregulated in cervical cancer tissues and cells. It promotes cervical cancer progression by sponging miR-429 to increase SOX2 expression, thereby enhancing proliferation, colony formation, migration, and xenograft tumor growth. The study proposes hsa_circ_0084912 as a potential therapeutic target for cervical cancer."	0.7795
36913151	Molecular and cellular biochemistry	2023	"circPTK2 promotes proliferation, migration and invasion of trophoblast cells through the miR-619/WNT7B pathway in preeclampsia."	hsa_circ_0005273		hsa_circ_PTK2	PTK2	preeclampsia / PE	MONDO:0005081	preeclampsia	down-regulated	RT-qPCR	"circPTK2 is down-regulated in placental tissues from PE/EOPE patients. Functionally, circPTK2 promotes trophoblast proliferation, migration, invasion and glucose metabolism, while its knockdown suppresses these processes. Mechanistically, circPTK2 acts as a miR-619 sponge to regulate WNT7B expression, supporting its potential as a biomarker and therapeutic target for EOPE."	0.725
36915755	American journal of translational research	2023	Diagnostic and prognostic value of serum CircERBB2 level in NSCLC and its correlation with clinicopathological features in NSCLC patients.			hsa_circ_ERBB2	ERBB2	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"CircERBB2 was measured in serum from NSCLC patients, benign lung disease patients, and healthy controls, and was found to be highly expressed in NSCLC. Higher serum CircERBB2 was associated with tumor diameter, lymph node metastasis, TNM stage, increased death-group levels, worse 36-month survival, and good diagnostic performance, especially when combined with CEA. The study did not investigate a molecular mechanism for CircERBB2 in NSCLC."	0.4992
36916930	Neoplasma	2023	Circular RNA hsa_circ_0002938 (circCRIM1) promotes the progression of esophageal squamous cell carcinoma by upregulating transcription factor 12.	hsa_circ_0002938		hsa_circ_CRIM1	CRIM1	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"hsa_circ_0002938, also named circCRIM1, is an upregulated onco-circRNA in ESCC derived from CRIM1. It promotes ESCC cell proliferation, colony formation, migration, invasion, and EMT by acting as a ceRNA for miR-342-3p to increase TCF12 expression. Its high expression correlates with advanced TNM stage, tumor invasion range, and lymph node metastasis, suggesting biomarker and therapeutic potential."	0.8351
36918335	Burns : journal of the International Society for Burn Injuries	2023	"Circ_0008450 regulates keloid-derived fibroblast proliferation, migration, invasion and apoptosis with increased IGFBP5 through sponging miR-1224-5p."	hsa_circ_0008450		hsa_circ_CMTM3	CMTM3	keloid	MONDO:0005348	keloid	up-regulated	RT-qPCR	"Circ_0008450 is up-regulated in keloid tissues and keloid-derived fibroblasts and mainly localizes to the cytoplasm. It promotes fibroblast proliferation, cell cycle progression, migration, invasion and ECM marker expression while inhibiting apoptosis. Mechanistically, circ_0008450 sponges miR-1224-5p to increase IGFBP5 expression, forming a circ_0008450/miR-1224-5p/IGFBP5 regulatory axis with potential therapeutic relevance in keloid."	0.7799
36920044	Molecular carcinogenesis	2023	Circular RNA ACACA negatively regulated p53-modulated mevalonate pathway to promote colorectal tumorigenesis via regulating miR-193a/b-3p/HDAC3 axis.	hsa_circ_0043216	circRNA acetyl-CoA carboxylase alpha	hsa_circ_ACACA	ACACA	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circACACA is upregulated in colorectal cancer tissues and cell lines and is associated with advanced clinicopathological features and poor overall survival. Functionally, it promotes CRC proliferation, migration, invasion, tumor growth and metastasis while suppressing apoptosis. Mechanistically, circACACA sponges miR-193a-3p and miR-193b-3p to increase HDAC3, reduce p53 acetylation/transcriptional activity, and activate the MVA pathway."	0.8912
36920046	Molecular carcinogenesis	2023	"Circ_0007429/miR-637/TRIM71/Ago2 axis participates in the regulation of proliferation, migration, invasion, apoptosis, and aerobic glycolysis of HCC."	hsa_circ_0007429	circ_0007429 / circRNA_0007429	hsa_circ_RREB1	RREB1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0007429 is an upregulated RREB1-derived cytoplasmic circRNA in HCC. It promotes HCC progression by sponging miR-637 to increase TRIM71 and regulate Ago2, thereby enhancing proliferation, migration, invasion, cell cycle progression, aerobic glycolysis and tumor growth while suppressing apoptosis. High circ_0007429 expression is associated with larger tumor size and worse overall survival."	0.8673
36920626	Metabolic brain disease	2023	Hsa_circ_0001361 facilitates cell progression and glycolytic metabolism in neuroblastoma via interacting with mir-490-5p to induce TRIM2 upregulation.	hsa_circ_0001361	circ-FNDC3B	hsa_circ_FNDC3B	FNDC3B	neuroblastoma / NB	MONDO:0005072	neuroblastoma	up-regulated	RT-qPCR	"Hsa_circ_0001361 is up-regulated in neuroblastoma tissues and cells and functions as an oncogenic circRNA. It promotes proliferation, migration, invasion, glycolysis and xenograft tumor growth by sponging miR-490-5p and upregulating TRIM2."	0.8175
36920708	Biochemical genetics	2023	Circ_0005615 Regulates the Progression of Colorectal Cancer Through the miR-873-5p/FOSL2 Signaling Pathway.	hsa_circ_0005615	circ_0005615	hsa_circ_NFATC3	NFATC3	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0005615 is up-regulated in CRC tissues, CRC cell lines, and serum exosomes from CRC patients. It promotes malignant CRC progression by sponging miR-873-5p and increasing FOSL2 expression, thereby enhancing proliferation, migration, invasion, metastasis, and tumor growth while suppressing apoptosis. High circ_0005615 expression is associated with adverse clinicopathological features and poor survival, suggesting biomarker and therapeutic relevance."	0.8069
36922625	Leukemia	2023	Impact of U2AF1 mutations on circular RNA expression in myelodysplastic neoplasms.		circMAN1A2	hsa_circ_MAN1A2	MAN1A2	myelodysplastic neoplasms / MDS	MONDO:0018881	myelodysplastic syndrome	up-regulated	RNA-seq	"circMAN1A2 was one of seven circRNAs upregulated in MDS patients with U2AF1 mutations and independently confirmed in cohort 2. Functional knockdown in U2AF1-mutated K562 cells altered cancer-panel gene expression, especially IL32, MS4A4A, FOSL1 and MAGEC1, suggesting a potential role in U2AF1-mutated MDS biology."	0.4997
36922625	Leukemia	2023	Impact of U2AF1 mutations on circular RNA expression in myelodysplastic neoplasms.		circZNF609	hsa_circ_ZNF609	ZNF609	myelodysplastic neoplasms / MDS	MONDO:0018881	myelodysplastic syndrome	up-regulated	RNA-seq	circZNF609 was upregulated in MDS patients with U2AF1 mutations and selected for knockdown because it was highly expressed in U2AF1-mutated K562 clones and previously described in cancer. Its knockdown had limited transcriptional effects compared with circCSNK1G3 and circMAN1A2.	0.4997
36922625	Leukemia	2023	Impact of U2AF1 mutations on circular RNA expression in myelodysplastic neoplasms.		circCSNK1G3	hsa_circ_CSNK1G3	CSNK1G3	myelodysplastic neoplasms / MDS	MONDO:0018881	myelodysplastic syndrome	up-regulated	RNA-seq	"circCSNK1G3 was upregulated in U2AF1-mutated MDS and selected for functional study. Its knockdown caused substantial transcriptional changes in U2AF1 Q157P K562 cells, especially affecting IL32, MMP9, TWF1 and MS4A4A, supporting a biologically relevant role."	0.4997
36922625	Leukemia	2023	Impact of U2AF1 mutations on circular RNA expression in myelodysplastic neoplasms.		circKATNAL2	hsa_circ_KATNAL2	KATNAL2	myelodysplastic neoplasms / MDS	MONDO:0018881	myelodysplastic syndrome	up-regulated	RNA-seq	circKATNAL2 was identified as one of seven circRNAs significantly upregulated in U2AF1-mutated MDS and also differentially expressed in an independent cohort. No circKATNAL2-specific functional mechanism was tested.	0.348
36922625	Leukemia	2023	Impact of U2AF1 mutations on circular RNA expression in myelodysplastic neoplasms.		circTRIM58	hsa_circ_TRIM58	TRIM58	myelodysplastic neoplasms / MDS	MONDO:0018881	myelodysplastic syndrome	up-regulated	RNA-seq	circTRIM58 was identified as one of seven circRNAs significantly upregulated in U2AF1-mutated MDS and also differentially expressed in an independent cohort. No circTRIM58-specific functional mechanism was tested.	0.348
36922625	Leukemia	2023	Impact of U2AF1 mutations on circular RNA expression in myelodysplastic neoplasms.		circUBAP2	hsa_circ_UBAP2	UBAP2	myelodysplastic neoplasms / MDS	MONDO:0018881	myelodysplastic syndrome	up-regulated	RNA-seq	circUBAP2 was identified as one of seven circRNAs significantly upregulated in U2AF1-mutated MDS and also differentially expressed in an independent cohort. No circUBAP2-specific functional mechanism was tested.	0.348
36922625	Leukemia	2023	Impact of U2AF1 mutations on circular RNA expression in myelodysplastic neoplasms.		circPDHX	hsa_circ_PDHX	PDHX	myelodysplastic neoplasms / MDS	MONDO:0018881	myelodysplastic syndrome	up-regulated	RNA-seq	circPDHX was identified as one of seven circRNAs significantly upregulated in U2AF1-mutated MDS and also differentially expressed in an independent cohort. No circPDHX-specific functional mechanism was tested.	0.348
36925229	"Endocrinologia, diabetes y nutricion"	2023	Overexpression of circRNAs LRP6 in gestational diabetes mellitus predicts foetal malformation and intrauterine death.		circRNA LRP6 /  hsa circRNA 101014	hsa_circ_LRP6	LRP6	gestational diabetes mellitus / GDM	MONDO:0005406	gestational diabetes	up-regulated	RT-qPCR	"This clinical cohort study found that plasma circRNA LRP6 is up-regulated in women who developed GDM. High LRP6 levels before pregnancy could predict future GDM risk and were associated with foetal malformation and intrauterine death, but no disease-specific molecular mechanism was experimentally tested."	0.4758
36928742	Molecular biotechnology	2023	Circ_0058063 Contributed to Oral Squamous Cell Carcinoma Development by Sponging miR-145 and Regulating PI3K/AKT Pathway.	hsa_circ_0058063	circ_0058063	hsa_circ_ATIC	ATIC	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circ_0058063 is up-regulated in OSCC tissues and cell lines and acts as an oncogenic circRNA. It promotes OSCC cell viability, adhesion, migration, EMT, and xenograft tumorigenicity by sponging miR-145-5p and activating PI3K/AKT signaling. The study suggests circ_0058063 may have potential value for OSCC diagnosis and treatment."	0.8111
36929708	Acta biochimica Polonica	2023	Circular RNA LPAR3 targets JPT1 via microRNA-513b-5p to facilitate glycolytic activation but repress prostate cancer radiosensitivity.		circRNA lysophosphatidic acid receptor 3 (LPAR3) / circLPAR3	hsa_circ_LPAR3	LPAR3	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circLPAR3 is up-regulated in prostate cancer tissues and cell lines and high expression is linked to worse clinicopathological features and poor survival. Functionally, circLPAR3 promotes PCa cell advancement and glycolysis while reducing radiosensitivity. Mechanistically, it acts as a sponge for miR-513b-5p to regulate JPT1 in the circLPAR3/miR-513b-5p/JPT1 axis."	0.8463
36935520	Journal of biochemical and molecular toxicology	2023	Circular RNA SLTM as a miR-421-competing endogenous RNA to mediate HMGB2 expression stimulates apoptosis and inflammation in arthritic chondrocytes.	hsa_circ_0000605	Circular RNA SLTM / circSLTM	hsa_circ_SLTM	SLTM	Osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"circSLTM is up-regulated in IL-1beta-induced OA chondrocytes and in OA rat cartilage/knee tissue models. It functions as a miR-421-competing endogenous RNA to regulate HMGB2, thereby promoting NF-kappaB-related inflammation, ROS production, apoptosis, and cartilage damage; knockdown of circSLTM alleviates OA-like injury in vitro and in vivo."	0.6279
36939994	Molecular and cellular biochemistry	2023	"NR1H4-mediated circRHOBTB3 modulates the proliferation, metastasis, and Warburg effects of cervical cancer through interacting with IGF2BP3."	hsa_circ_0007444	Circular RNA Rho-related BTB domain-containing 3 / circRHOBTB3	hsa_circ_RHOBTB3	RHOBTB3	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"CircRHOBTB3/hsa_circ_0007444 is up-regulated in cervical cancer cell lines and functions as an oncogenic circRNA. Its knockdown suppresses proliferation, migration, invasion, and Warburg effects, while mechanistically it interacts with IGF2BP3 to stabilize IGF2BP3 expression and is putatively transcriptionally regulated by NR1H4."	0.7909
36947153	Cardiovascular journal of Africa	2023	CircRNA-mediated pathology: a new preliminary insight into the mechanism of type II cardio-renal syndrome.	hsa_circ_0001763				cardio-renal syndrome	MONDO:0044079	cardio-renal syndrome	up-regulated	RT-qPCR; Microarray	"hsa_cir_0001763/hsa_circ_0001763 was identified as an up-regulated peripheral blood circRNA in patients with type II cardio-renal syndrome by microarray and validated by qPCR in an independent cohort. It showed strong diagnostic performance for type II cardio-renal syndrome, but its precise molecular mechanism and biological function were not definitively established in this study."	0.5534
36947452	Environmental toxicology	2023	Hsa_circ_0003528 promotes cell malignant transformation and immune escape via increasing oncogene PDL1 through sponging miR-511-3p in non-small cell lung cancer.	hsa_circ_0003528	circ_0003528	hsa_circ_SEC24A	SEC24A	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"In this study, circ_0003528 was up-regulated in NSCLC tissues and cell lines and high expression predicted worse prognosis. Functionally, circ_0003528 promoted malignant transformation, angiogenesis, immune escape, and xenograft tumor growth while suppressing apoptosis. Mechanistically, it acted as a cytoplasmic sponge for miR-511-3p to increase PDL1 expression, forming a circ_0003528/miR-511-3p/PDL1 regulatory axis."	0.8354
36950992	Ecotoxicology and environmental safety	2023	Exosomal circCLIP1 regulates PM2.5-induced airway obstruction via targeting SEPT10 in vitro.	hsa_circ_0029069	circCLIP1	hsa_circ_CLIP1	CLIP1	PM2.5-induced airway obstruction	MONDO:0005087	respiratory system disorder	up-regulated	RT-qPCR; RNA-seq	"This study identifies exosomal circCLIP1, derived from CLIP1, as an up-regulated circRNA after PM2.5 exposure. METTL3-mediated m6A modification increases circCLIP1 expression and exosomal abundance, and exosome-transmitted circCLIP1 promotes mucus hypersecretion in HBE cells and contractility in sensitive HBSMCs by enhancing SEPT10. Human plasma data suggest exosomal circCLIP1 may serve as a biomarker of PM2.5-related adverse effects."	0.8414
36952219	Molecular biotechnology	2023	Regulation of Cervical Cancer Development by a Novel Circ_0000212/miR-1236-3p/GREM1 ceRNA Crosstalk.	hsa_circ_0000212	circ_0000212	hsa_circ_SFMBT2	SFMBT2	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ_0000212 is up-regulated in human cervical cancer tissues and cell lines and is mainly localized in the cytoplasm. It promotes cervical cancer progression by acting as a ceRNA for miR-1236-3p to increase GREM1 expression, thereby enhancing proliferation, EMT, migration, invasion, angiogenic tube formation and xenograft tumor growth while suppressing apoptosis."	0.7859
36961205	IUBMB life	2023	FOXC2-induced circCASK aggravates colorectal cancer progression by upregulating SIX1 expression.	hsa_circ_0001917	circCASK / circ_0001917	hsa_circ_CASK	CASK	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; ISH; Microarray	"circCASK (hsa_circ_0001917), derived from the CASK gene, is upregulated in CRC tissues and cell lines. FOXC2 induces circCASK transcription, and cytoplasmic circCASK promotes CRC proliferation, migration, invasion, and xenograft tumor growth by sponging miR-1271-5p, increasing SIX1 expression, and activating Wnt/beta-catenin and EMT-related programs. The study suggests circCASK has potential biomarker and therapeutic-target value in CRC."	0.8571
36967607	Autoimmunity	2023	Identification of a circRNA-miRNA-mRNA network to explore the effects of circRNAs on renal injury in systemic lupus erythematosus.	hsa_circ_0000006	circ-0000006 / hsa_circRNA_001621			systemic lupus erythematosus	MONDO:0007915	systemic lupus erythematosus	up-regulated	Microarray	"circ-0000006 was identified through GEO-based bioinformatics analysis as an up-regulated hub circRNA in SLE renal tissue and a candidate marker of SLE kidney injury within a circRNA-miRNA-mRNA ceRNA network. Its diagnostic performance was modest (AUC 0.764), and qRT-PCR validation in PBMCs did not confirm significant differential expression, so the evidence remains low-confidence and requires further confirmation."	0.348
36971486	Archives of physiology and biochemistry	2024	hsa_circ_0000047 targeting miR-6720-5p/CYB5R2 axis alleviates inflammation and angiogenesis in diabetic retinopathy.	hsa_circ_0000047		hsa_circ_YARS	YARS	diabetic retinopathy / DR	MONDO:0005266	diabetic retinopathy	down-regulated	RT-qPCR	"hsa_circ_0000047 is downregulated in blood samples from patients with diabetic retinopathy and in high-glucose-induced hRMECs. Its overexpression alleviates HG-induced inflammatory factor production, migration, invasion, tube formation, and angiogenesis by sponging miR-6720-5p and regulating CYB5R2, suggesting a potential therapeutic strategy for DR."	0.7177
36973217	Zhonghua yi xue za zhi	2023	[Expression and clinical significance of circRNA cSMARCA5 in patients with acute myocardial infarction].	hsa_circ_0001445	cSMARCA5	hsa_circ_SMARCA5	SMARCA5	acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	down-regulated	RT-qPCR	"cSMARCA5 (hsa_circ_0001445), derived from SMARCA5, is significantly down-regulated in the peripheral blood of AMI patients. Its lower expression is associated with greater myocardial injury and higher severity scores, and it shows potential diagnostic value for AMI. Bioinformatics analysis suggests that cSMARCA5 may participate in AMI through a predicted miRNA-mRNA regulatory network involving TNF."	0.459
36990335	Cellular signalling	2023	CircZFR promotes pancreatic cancer progression through a novel circRNA-miRNA-mRNA pathway and stabilizing epithelial-mesenchymal transition protein.		CircZFR	hsa_circ_ZFR	ZFR	Pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; Microarray	"circZFR is upregulated in pancreatic cancer tissues and cell lines, and high expression is associated with lymph node metastasis and poor overall and disease-free survival. Functionally, circZFR promotes pancreatic cancer proliferation, invasion, tumorigenicity, and EMT-related malignant behavior. Mechanistically, circZFR sponges miR-375 to increase GREM2 expression and activate the GREM2/JNK signaling pathway."	0.8632
36994684	Advances in clinical and experimental medicine : official organ Wroclaw Medical University	2023	hsa_circ_0017842 acts as a competing endogenous RNA to enhance the malignancy of gastric cancer.	hsa_circ_0017842		hsa_circ_FAM188A	FAM188A	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0017842 is up-regulated in gastric cancer tissues and cell lines. It promotes GC cell proliferation, migration and invasion by acting as a ceRNA that sponges miR-1294 and upregulates SPARC, suggesting an oncogenic role and potential therapeutic relevance."	0.7759
36995321	Clinical and experimental rheumatology	2023	High-throughput RNA-sequencing reveals novel targets of tofacitinib in the treatment of rheumatoid arthritis.	hsa_circ_0034415				rheumatoid arthritis / RA	MONDO:0008383	rheumatoid arthritis	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0034415 was identified in PBMCs from active RA patients as part of a tofacitinib-response-associated ceRNA network. It was downregulated after tofacitinib treatment in responders and was proposed to competitively bind miR-1298-5p together with DEPDC1, forming a circRNA-miRNA-mRNA regulatory axis relevant to RA therapy."	0.4032
36995659	Applied biochemistry and biotechnology	2023	Exosomal Circ_FMN2 Derived from the Serum of Colorectal Cancer Patients Promotes Cancer Progression by miR-338-3p/MSI1 Axis.		Circ_0005100 / circ_FMN2	hsa_circ_FMN2	FMN2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"Serum exosomal circ_FMN2 is upregulated in CRC patients and CRC cells. It promotes CRC proliferation, metastasis, EMT and tumor growth while inhibiting apoptosis, mainly by sponging miR-338-3p and upregulating MSI1. The study suggests exosomal circ_FMN2 as a potential therapeutic target for CRC."	0.8006
36999202	The journal of gene medicine	2023	Circ_0073228 serves as a competitive endogenous ribonucleic acid to facilitate proliferation and inhibit apoptosis of hepatocellular carcinoma cells by the miR-139-5p/deoxyribonuclease II axis.	hsa_circ_0073228	circ_0073228 / circ-RPS23	hsa_circ_RPS23	RPS23	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0073228 is an RPS23-derived circRNA upregulated in HCC cell lines. It promotes HCC cell growth, proliferation, migration and invasion and suppresses apoptosis by competitively binding miR-139-5p to increase DNASE2 expression."	0.741
36999488	Environmental toxicology	2023	Inhibition of sepsis-induced acute kidney injury via the circITCH-miR-579-3p-ZEB2 axis.		CircRNA E3 ubiquitin protein ligase (ITCH) / circITCH	hsa_circ_ITCH	ITCH	sepsis-induced acute kidney injury	MONDO:0002492	acute kidney injury	down-regulated	RT-qPCR	"CircITCH is downregulated in serum from septic AKI patients and in LPS-treated HK-2 cells. Overexpression of circITCH protects HK-2 cells from LPS-induced injury by improving cell viability and suppressing apoptosis and inflammatory cytokine production. Mechanistically, circITCH acts as a sponge for miR-579-3p and upregulates ZEB2 through the circITCH/miR-579-3p/ZEB2 axis."	0.6996
37000289	Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico	2023	"Hsa_circ_0001535 inhibits the proliferation and migration of ovarian cancer by sponging miR-593-3p, upregulating PTEN expression."	hsa_circ_0001535				ovarian cancer / OC	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR	"Hsa_circ_0001535 is down-regulated in ovarian cancer tissues and cell lines. Its overexpression suppresses ovarian cancer cell proliferation, migration and EMT marker expression by sponging miR-593-3p and increasing PTEN expression, indicating a tumor-suppressive role and potential therapeutic relevance."	0.7078
37005319	International heart journal	2023	Ox-LDL-Induced Vascular Smooth Muscle Cell Dysfunction Partly Depends on the Circ_0044073/miR-377-3p/AURKA Axis in Atherosclerosis.	hsa_circ_0044073	circ_0044073	hsa_circ_GRN	GRN	Atherosclerosis / AS	MONDO:0005311	atherosclerosis	up-regulated	RT-qPCR	"hsa_circ_0044073/circ_0044073 is up-regulated in serum from AS patients and in Ox-LDL-stimulated human VSMCs. It promotes VSMC proliferation, migration, invasion, and inflammation by sponging miR-377-3p and increasing AURKA expression, suggesting a potential therapeutic target in atherosclerosis."	0.8118
37005320	International heart journal	2023	"CircUSP39/miR-362-3p/TRAF3 Axis Mediates Hypoxia/Reoxygenation-Induced Cardiomyocyte Oxidative Stress, Inflammation, and Apoptosis."	hsa_circ_0055440	circUSP39 / circRNA ubiquitin-specific peptidase 39	hsa_circ_USP39	USP39	acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR; Microarray	"This study identified circUSP39 (hsa_circ_0055440), derived from USP39, as an up-regulated circRNA in AMI patient blood microarray data and in H/R-induced human AC16 cardiomyocytes. Functionally, circUSP39 promotes H/R-induced cardiomyocyte oxidative stress, inflammatory cytokine secretion, and apoptosis by sponging miR-362-3p and thereby increasing TRAF3 expression, suggesting potential therapeutic relevance in AMI-associated myocardial injury."	0.8081
37005876	Cancer biomarkers : section A of Disease markers	2023	Circ_0067997 boosted the growth while repressed the apoptosis of SGC-7901/DDP cells via repressing miR-615-5p/AKT1 pathway.	hsa_circ_0067997	circ_0067997			gastric cancer / GC	MONDO:0001056 	gastric cancer	up-regulated	RT-qPCR	"circ_0067997 is up-regulated in gastric cancer, especially in cisplatin-insensitive GC tissues and SGC-7901/DDP cells. It promotes GC cell growth, tumor formation and DDP resistance while inhibiting apoptosis, at least partly by sponging miR-615-5p to regulate AKT1. Its expression is associated with clinicopathologic severity and may represent a detection and therapeutic target for GC."	0.7032
37005879	Cancer biomarkers : section A of Disease markers	2023	Hsa_circ_0070661 inhibits cancer progression through miR-556-5p/TEK axis in lung adenocarcinoma.	hsa_circ_0070661		hsa_circ_CCDC109B	CCDC109B	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR	"Hsa_circ_0070661 is down-regulated in LUAD tissues and cell lines and mainly localized in the cytoplasm. Its overexpression suppresses LUAD cell proliferation/viability, migration and xenograft tumor growth while promoting apoptosis. Mechanistically, it sponges miR-556-5p to relieve repression of TEK, supporting its role as a tumor-suppressive circRNA and potential therapeutic target."	0.7785
37012879	International immunopharmacology	2023	Cardioprotective effects of circ_0002612 in myocardial ischemia/reperfusion injury correlate with disruption of miR-30a-5p-dependent Ppargc1a inhibition.	mmu_circ_0002612	circ_0002612			myocardial ischemia/reperfusion injury	MONDO:0005203	ischemia reperfusion injury	down-regulated	RT-qPCR; RNA-seq	"circ_0002612 is down-regulated in mouse MI/RI myocardial tissues and H/R-challenged cardiomyocytes. It exerts cardioprotective effects by sponging miR-30a-5p, derepressing Ppargc1a, reducing NLRP3 expression, promoting cardiomyocyte viability/proliferation, and inhibiting apoptosis and infarct progression."	0.7221
37014014	Environmental toxicology	2023	Hsa_circ_0008500 inhibits apoptosis of adipose-derived stem cells under high glucose through hsa-miR-1273h-5p/ELK1 axis.	hsa_circ_0008500	circ_0008500			diabetes	MONDO:0005015	diabetes mellitus	down-regulated	RT-qPCR	"hsa_circ_0008500 is downregulated in ADSCs under high-glucose conditions relevant to diabetic wounds. It inhibits high glucose-induced ADSC apoptosis by sponging hsa-miR-1273h-5p and relieving suppression of ELK1, suggesting potential therapeutic value for diabetic wound/DFU repair."	0.7884
37014258	Autophagy	2023	"CircEPS15, as a sponge of MIR24-3p ameliorates neuronal damage in Parkinson disease through boosting PINK1-PRKN-mediated mitophagy."		circEPS15	hsa_circ_EPS15	EPS15	Parkinson's disease / PD	MONDO:0005180	Parkinson disease	down-regulated	RT-qPCR; ISH; RNA-seq	"circEPS15 is downregulated in plasma of PD patients and in MPTP-induced PD mouse models, and lower levels correlate with worse PD motor severity. Functionally, circEPS15 overexpression protects dopaminergic neurons in vitro and in vivo by sponging MIR24-3p, increasing PINK1 expression, and boosting PINK1-PRKN-mediated mitophagy to maintain mitochondrial homeostasis. The study proposes circEPS15 as a potential biomarker and therapeutic target for Parkinson disease."	0.8792
37017678	"Journal of environmental pathology, toxicology and oncology : official organ of the International Society for Environmental Toxicology and Cancer"	2023	Circular RNA 0000311 Aggravates the Aggressiveness of Oral Squamous Cell Carcinoma via miR-876-5p/EZH2 Axis.	hsa_circ_0000311	circ_0000311			oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	up-regulated	RT-qPCR	"circ_0000311 is up-regulated in OSCC tissues and cells. It aggravates OSCC progression by sponging miR-876-5p and increasing EZH2 expression, thereby promoting proliferation, migration, invasion and EMT while suppressing apoptosis. The study suggests circ_0000311 may serve as a potential OSCC biomarker and therapeutic target."	0.7045
37017919	Journal of endocrinological investigation	2023	Hsa_circ_0003928 regulates the progression of diabetic nephropathy through miR-136-5p/PAQR3 axis.	hsa_circ_0003928	circ_0003928	hsa_circ_TAOK1	TAOK1	diabetic nephropathy / DN	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"Hsa_circ_0003928/circ_0003928 is up-regulated in DN patient serum and high glucose-induced HK-2 cells. It functions as a pathogenic circRNA in the in vitro DN model by sponging miR-136-5p to increase PAQR3 expression, thereby inhibiting proliferation and promoting apoptosis, oxidative stress, and fibrosis."	0.7045
37021367	Journal of immunotoxicology	2023	Hsa_circ_0044235 and hsa_circ_0001947 as novel biomarkers in plasma of patients with new-onset systemic lupus erythematosus.	hsa_circ_0000175				systemic lupus erythematosus	MONDO:0007915	systemic lupus erythematosus	down-regulated	RT-qPCR	"hsa_circ_0000175 was significantly down-regulated in plasma from patients with new-onset SLE compared with healthy and RA controls. It was validated by RT-qPCR in clinical plasma samples, but it was not identified as an independent SLE risk factor."	0.2995
37021367	Journal of immunotoxicology	2023	Hsa_circ_0044235 and hsa_circ_0001947 as novel biomarkers in plasma of patients with new-onset systemic lupus erythematosus.	hsa_circ_0044235				systemic lupus erythematosus	MONDO:0007915	systemic lupus erythematosus	down-regulated	RT-qPCR	"hsa_circ_0044235 is down-regulated in plasma from patients with new-onset SLE and its decreased level is an independent positive risk factor for SLE. It has diagnostic value alone and in combination with hsa_circ_0001947, and its plasma level correlates with PLT, PCT and PDW, suggesting relevance to disease severity monitoring."	0.459
37021367	Journal of immunotoxicology	2023	Hsa_circ_0044235 and hsa_circ_0001947 as novel biomarkers in plasma of patients with new-onset systemic lupus erythematosus.	hsa_circ_0068367				systemic lupus erythematosus	MONDO:0007915	systemic lupus erythematosus	down-regulated	RT-qPCR	"hsa_circ_0068367 was significantly down-regulated in plasma from patients with new-onset SLE compared with healthy and RA controls. Its differential expression was validated by RT-qPCR, but it was not identified as an independent SLE risk factor."	0.2995
37021367	Journal of immunotoxicology	2023	Hsa_circ_0044235 and hsa_circ_0001947 as novel biomarkers in plasma of patients with new-onset systemic lupus erythematosus.	hsa_circ_0001947				systemic lupus erythematosus	MONDO:0007915	systemic lupus erythematosus	down-regulated	RT-qPCR	"hsa_circ_0001947 is down-regulated in plasma from patients with new-onset SLE and its decreased level is an independent positive risk factor for SLE. It has diagnostic value alone and in combination with hsa_circ_0044235, and its plasma expression increases after treatment, suggesting potential utility for monitoring patient response."	0.459
37023555	"Pathology, research and practice"	2023	hsa_circ_0136839 regulates the malignant phenotypes of nasopharyngeal carcinoma via the Wnt/beta-catenin signaling pathway.	hsa_circ_0136839		hsa_circ_ERICH1	ERICH1	nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	down-regulated	RT-qPCR; RNA-seq	"hsa_circ_0136839 is downregulated in NPC tissues and acts as a tumor-suppressive circRNA. Its knockdown promotes NPC cell proliferation, migration, invasion, and cell-cycle alteration, whereas overexpression suppresses these malignant phenotypes, likely through inhibition of the Wnt/beta-catenin signaling pathway."	0.7415
37027893	Archives of oral biology	2023	Profiling of circRNA expressions in radiation-treated head and neck cancer cells and the potential role of circPVT1.	hsa_circ_0004315		hsa_circ_GLG1	GLG1	head and neck cancer / HNC	MONDO:0005627	head and neck cancer	up-regulated	RT-qPCR	"hsa_circ_0004315 is markedly up-regulated in Detroit-562 HNC cells compared with WI-38 control cells and is significantly reduced after irradiation. The study suggests it may serve as a biomarker candidate for HNC diagnosis, prognosis, or radiotherapy monitoring, with predicted involvement in RNA catabolic processes and protein complex regulation."	0.329
37027893	Archives of oral biology	2023	Profiling of circRNA expressions in radiation-treated head and neck cancer cells and the potential role of circPVT1.	hsa_circ_0005075		hsa_circ_EIF4G3	EIF4G3	head and neck cancer / HNC	MONDO:0005627	head and neck cancer	up-regulated	RT-qPCR	"hsa_circ_0005075 is markedly up-regulated in Detroit-562 HNC cells compared with WI-38 control cells and is significantly reduced after irradiation. The study suggests it may be a biomarker candidate for HNC diagnosis, prognosis, or radiotherapy monitoring, and KEGG-based prediction links it to autophagic mechanisms."	0.329
37027893	Archives of oral biology	2023	Profiling of circRNA expressions in radiation-treated head and neck cancer cells and the potential role of circPVT1.	hsa_circ_0001821	circPVT1	hsa_circ_PVT1	PVT1	head and neck cancer / HNC	MONDO:0005627	head and neck cancer	up-regulated	RT-qPCR	"hsa_circ_0001821/circPVT1, derived from the PVT1 locus, is significantly up-regulated in Detroit-562 HNC cells and HNC cancer tissue and is reduced after irradiation. The study predicts circPVT1-miRNA interactions and proposes circPVT1 as a potential biomarker for monitoring radiotherapy effects in HNC patients, although its association with poor overall survival was not statistically significant."	0.4685
37028497	Toxicology letters	2023	"CircBCL11B acts as a ceRNA to facilitate 1,2-dichloroethane-induced astrocyte swelling via miR-29b-3p/AQP4 axis in SVG p12 cells."	hsa_circ_0033144	circBCL11B	hsa_circ_BCL11B	BCL11B	brain edema	MONDO:0006684	brain edema	up-regulated	RT-qPCR; RNA-seq	"circBCL11B is up-regulated after 1,2-DCE exposure in SVG p12 human astrocyte-like cells. It functions as a ceRNA by binding miR-29b-3p, relieving miR-29b-3p-mediated inhibition of AQP4, thereby promoting AQP4 upregulation and astrocyte swelling. Knockdown of circBCL11B reverses 1,2-DCE-induced AQP4 upregulation and alleviates cell swelling."	0.6868
37029728	Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology	2023	Highly expressed circ_0000285 from serum and cervical exfoliated cells as a novel biomarker for the diagnosis of early stage-cervical cancer.	hsa_circ_0000285	circRNA_0000285	hsa_circ_HIPK3	HIPK3	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"This study found that circ_0000285 is up-regulated in serum and cervical exfoliated cells from cervical cancer patients and in cervical cancer cell lines. Its expression shows diagnostic value for CC and ESCC, is superior to CA125 and SCC-Ag in ROC analysis, and high postoperative serum levels are associated with tumour relapse."	0.5727
37031335	Molecular biotechnology	2024	Hsa_circITGA4/ miR-1468/EGFR/ PTEN a Master Regulators Axis in Glioblastoma Development and Progression.		hsa_circITGA4_002	hsa_circ_ITGA4	ITGA4	glioblastoma / GBM	MONDO:0018177	glioblastoma	dysregulated	RNA-seq; Microarray	"hsa_circITGA4_002 was identified by bioinformatics analysis as a dysregulated circRNA in GBM. The study predicts that it participates in a circRNA-miRNA-mRNA sponge network involving hsa-miR-1468/hsa-miR-4665-3p and GBM-related genes such as EGFR, PTEN and ITGA4, suggesting potential diagnostic or therapeutic relevance."	0.329
37031335	Molecular biotechnology	2024	Hsa_circITGA4/ miR-1468/EGFR/ PTEN a Master Regulators Axis in Glioblastoma Development and Progression.		hsa_circITGA4_001	hsa_circ_ITGA4	ITGA4	glioblastoma / GBM	MONDO:0018177	glioblastoma	dysregulated	RNA-seq; Microarray	"hsa_circITGA4_001 was identified as a dysregulated circRNA in GBM using bioinformatics datasets. It is predicted to act in a molecular sponge network involving hsa-miR-1468/hsa-miR-4665-3p and GBM-related genes, and it may have diagnostic or therapeutic value."	0.329
37031335	Molecular biotechnology	2024	Hsa_circITGA4/ miR-1468/EGFR/ PTEN a Master Regulators Axis in Glioblastoma Development and Progression.		hsa_circITGA4_003	hsa_circ_ITGA4	ITGA4	glioblastoma / GBM	MONDO:0018177	glioblastoma	dysregulated	RNA-seq; Microarray	"hsa_circITGA4_003 was predicted as a GBM-associated circRNA from circRNA sequencing/array datasets. The study links it to a putative molecular sponge network and suggests potential diagnostic or therapeutic use, although no experimental validation was performed."	0.329
37031335	Molecular biotechnology	2024	Hsa_circITGA4/ miR-1468/EGFR/ PTEN a Master Regulators Axis in Glioblastoma Development and Progression.	hsa_circ_0030855				glioblastoma / GBM	MONDO:0018177	glioblastoma	dysregulated	RNA-seq; Microarray	hsa_circ_0030855 was selected from GBM patient/control datasets and predicted to be part of a GBM-related circRNA regulatory network. Its specific host gene and exact interaction partners were not experimentally validated in the article.	0.329
37031335	Molecular biotechnology	2024	Hsa_circITGA4/ miR-1468/EGFR/ PTEN a Master Regulators Axis in Glioblastoma Development and Progression.	hsa_circ_0030857				glioblastoma / GBM	MONDO:0018177	glioblastoma	dysregulated	RNA-seq; Microarray	"hsa_circ_0030857 was identified as a dysregulated circRNA in GBM patient/control data. The study predicts it belongs to a circRNA molecular sponge regulatory network involving hsa-miR-1468/hsa-miR-4665-3p and genes such as EGFR, PTEN and ITGA4, making it a potential therapeutic target."	0.329
37031335	Molecular biotechnology	2024	Hsa_circITGA4/ miR-1468/EGFR/ PTEN a Master Regulators Axis in Glioblastoma Development and Progression.	hsa_circ_0030860				glioblastoma / GBM	MONDO:0018177	glioblastoma	dysregulated	RNA-seq; Microarray	"hsa_circ_0030860 was identified bioinformatically as a significant GBM-associated circRNA. The paper proposes that it may be useful for diagnostic or therapeutic applications, but does not provide RT-qPCR validation or a circRNA-specific molecular axis."	0.329
37031335	Molecular biotechnology	2024	Hsa_circITGA4/ miR-1468/EGFR/ PTEN a Master Regulators Axis in Glioblastoma Development and Progression.	hsa_circ_0077819				glioblastoma / GBM	MONDO:0018177	glioblastoma	dysregulated	RNA-seq; Microarray	"hsa_circ_0077819 was identified bioinformatically as a significant GBM-associated circRNA. The study suggests potential diagnostic or therapeutic relevance, but no circRNA-specific experimental validation or detailed molecular mechanism was reported."	0.329
37034216	American journal of cancer research	2023	Circ_0000231 promotes paclitaxel resistance in ovarian cancer by regulating miR-140/RAP1B.	hsa_circ_0000231	Circ_0000231	hsa_circ_ARHGAP12	ARHGAP12	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circ_0000231 is up-regulated in paclitaxel-resistant ovarian cancer tissues and cells. It promotes PTX resistance, proliferation, migration, invasion and EMT while suppressing apoptosis, mainly through the circ_0000231/miR-140/RAP1B ceRNA axis. Knockdown of circ_0000231 increases PTX sensitivity in vitro and in a cell line-derived xenograft model."	0.817
37034230	American journal of cancer research	2023	Circ8199 encodes a protein that inhibits the activity of OGT by JAK2-STAT3 pathway in esophageal squamous cell carcinoma.		hsa_ circ-00008199 / circ8199	hsa_circ_ATXN10	ATXN10	Esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	dysregulated	RT-qPCR; RNA-seq	"circ8199 is an ATXN10-derived human circRNA studied in ESCC and associated with patient prognosis, with high expression linked to better overall survival. Functionally, circ8199 suppresses ESCC cell proliferation, migration and colony formation, and it encodes a 235aa polypeptide that binds OGT and inhibits OGT enzymatic activity. Low circ8199 weakens this inhibition, enhancing OGT-JAK2 binding, JAK2 O-GlcNAc glycosylation and activation of the JAK2-STAT3 pathway."	0.8676
37035389	Heliyon	2023	Circular RNA hsa_circ_0005218 promotes the early recurrence of hepatocellular carcinoma by targeting the miR-31-5p/CDK1 pathway.	hsa_circ_0005218	circ_018131	hsa_circ_FAM120A		hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0005218/circ_0005218 is up-regulated in HCC, especially early recurrent HCC tissues, and high expression predicts poor OS and DFS. Functionally, it promotes HCC proliferation, migration, invasion, metastasis, cell cycle progression and xenograft growth. Mechanistically, it sponges miR-31-5p to relieve suppression of CDK1, supporting a circ_0005218/miR-31-5p/CDK1 regulatory axis and potential use as an early recurrence biomarker and therapeutic target."	0.8793
37040338	Environmental toxicology	2023	Circular forms of dedicator of cytokinesis 1 promotes breast cancer progression by derepressing never in mitosis related kinase 2 via sponging miR-128-3p.	hsa_circ_0007142	circular forms of dedicator of cytokinesis 1 / circDOCK1	hsa_circ_DOCK1	DOCK1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circDOCK1 (hsa_circ_0007142) is up-regulated in breast cancer tissues and cell lines. The study reports that circDOCK1 promotes breast cancer progression by sponging miR-128-3p and derepressing NEK2, thereby enhancing proliferation, migration, invasion, metastasis and tumor growth while reducing apoptosis. The circDOCK1/hsa-miR-128-3p/NEK2 axis is proposed as a potential therapeutic target."	0.6542
37041422	Apoptosis : an international journal on programmed cell death	2023	Downregulation of circ-STK39 suppresses pancreatic cancer progression by sponging mir-140-3p and regulating TRAM2-mediated epithelial-mesenchymal transition.	hsa_circ_0001079	circ-STK39	hsa_circ_STK39	STK39	pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; ISH; RNA-seq	"circ-STK39/hsa_circ_0001079 is up-regulated in pancreatic cancer tissues and cell lines. The study shows that silencing circ-STK39 suppresses pancreatic cancer proliferation, migration, tumor growth, pulmonary metastasis and EMT by releasing miR-140-3p and reducing TRAM2-mediated EMT signaling, suggesting biomarker and therapeutic potential."	0.7486
37042131	Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences	2023	"[Read-through circular RNA rt-circ-HS promotes hypoxia inducible factor 1alpha expression and renal carcinoma cell proliferation, migration and invasiveness]."		rt-circ-HS	hsa_circ_HIF1A-SNAPC1	HIF1A; SNAPC1	renal carcinoma	MONDO:0005206	renal carcinoma	up-regulated	RT-qPCR; ISH	"This study investigated the read-through circRNA rt-circ-HS in renal carcinoma. rt-circ-HS is up-regulated in renal carcinoma contexts and promotes HIF1A expression as well as renal carcinoma cell proliferation, migration and invasion, likely through a miR-485/HIF1A ceRNA mechanism."	0.7944
37044031	International immunopharmacology	2023	"Circ_0082476 targets miR-138-5p to promote proliferation, invasion, migration and inflammation in IL-22-treated human keratinocytes by upregulating BRD4."	hsa_circ_0082476	circ_0082476			psoriasis	MONDO:0005083	psoriasis	up-regulated	RT-qPCR	"circ_0082476 is up-regulated in serum from psoriasis patients and in IL-22-treated HaCaT keratinocytes. It promotes IL-22-mediated keratinocyte proliferation, invasion, migration and inflammatory responses by sponging miR-138-5p and increasing BRD4 expression, forming a circ_0082476/miR-138-5p/BRD4 regulatory axis."	0.7799
37044033	International immunopharmacology	2023	Hsa_circ_0073453 modulates IL-8 secretion by GC-MSCs to promote gastric cancer progression by sponging miR-146a-5p.	hsa_circ_0073453	circ_0073453	hsa_circ_RHOBTB3	RHOBTB3	gastric cancer / GC	MONDO:0001056	gastric cancer	dysregulated	RT-qPCR; Microarray	"This study identifies hsa_circ_0073453/circ_0073453 as a GC-MSC-derived circRNA involved in gastric cancer progression. It functions as a sponge for miR-146a-5p to increase IL-8 expression and secretion, thereby promoting gastric cancer cell migration, invasion, metastasis, PD-L1 upregulation, and resistance to CD8 + T cell cytotoxicity."	0.8625
37045727	Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology	2023	Circ_0060967 contributes to colorectal cancer progression by sponging miR-1184 to up-regulate SRC proto-oncogene.	hsa_circ_0060967	circ_0060967	hsa_circ_RAE1	RAE1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circ_0060967 is up-regulated in colorectal cancer tissues and CRC cell lines and correlates with tumor size, TNM stage, and distant metastasis. Functionally, circ_0060967 promotes CRC cell proliferation, migration, invasion, and xenograft tumor growth while inhibiting apoptosis. Mechanistically, it sponges miR-1184 to up-regulate SRC and activate the NF-kappaB pathway."	0.786
37052456	Environmental toxicology	2023	Silencing circular RNA hsa_circABCC1 inhibits osteosarcoma progression through down-regulating HDAC4 via sponging miR-591.		circ_ABCC1	hsa_circ_ABCC1	ABCC1	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circABCC1 is up-regulated in osteosarcoma tissues and cell lines and functions as a pro-oncogenic circRNA. Its knockdown suppresses osteosarcoma cell proliferation, migration, invasion and xenograft tumor growth while promoting apoptosis and autophagy, mainly through the circABCC1/miR-591/HDAC4 regulatory axis."	0.6835
37052807	Molecular biotechnology	2024	CircSCUBE3 Reduces the Anti-gastric Cancer Activity of Anti-PD-L1.	hsa_circ_0076092	circSCUBE3	hsa_circ_SCUBE3	SCUBE3	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circSCUBE3 is an up-regulated human circRNA in gastric cancer derived from the SCUBE3 gene. It promotes GC cell proliferation and immune escape through the circSCUBE3/miR-744-5p/SLC7A5 axis, regulates PD-L1 expression, and reduces the anti-tumor activity of anti-PD-L1 treatment in vivo. High circSCUBE3 expression is associated with lymph node metastasis, TNM staging, and worse 5-year survival."	0.8465
37059374	European journal of pharmacology	2023	Exosomal circCOL1A2 from cancer cells accelerates colorectal cancer progression via regulating miR-665/LASP1 signal axis.	hsa_circ_0081069	circCOL1A2	hsa_circ_COL1A2	COL1A2	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circCOL1A2 is up-regulated in CRC tissues, CRC cells, and CRC cell-derived exosomes, and high expression is linked to poor prognosis. Exosomal circCOL1A2 promotes CRC proliferation, migration, invasion, EMT, and in vivo tumor growth by sponging miR-665 and increasing LASP1 expression. The study suggests circCOL1A2 as a potential therapeutic target in CRC."	0.8766
37061192	Neurochemistry international	2023	Circular RNA XRCC5 aggravates glioma progression by activating CLC3/SGK1 axis via recruiting IGF2BP2.	hsa_circ_0058163	circXRCC5	hsa_circ_XRCC5	XRCC5	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; ISH	"circXRCC5 is up-regulated in glioma tissues and cell lines and high expression is associated with worse clinical features and poorer survival. Functionally, circXRCC5 promotes glioma proliferation, inflammasome activation and tumor growth by recruiting IGF2BP2 to stabilize CLC3 mRNA, thereby activating the CLC3/SGK1 axis through the PI3K/PDK1/AKT pathway."	0.8711
37062135	Phytomedicine : international journal of phytotherapy and phytopharmacology	2023	Fuzheng Kang-Ai inhibits NSCLC cell proliferation via regulating hsa_circ_0048091/hsa-miR-378g/ARRDC3 pathway.	hsa_circ_0048091		hsa_circ_PALM	PALM	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	hsa_circ_0048091 is a PALM-derived human circRNA induced by FZKA treatment in NSCLC cells and xenograft tumor tissues. It suppresses NSCLC cell proliferation/viability and mediates the anti-proliferative effect of FZKA by sponging hsa-miR-378g and regulating the downstream target ARRDC3.	0.8516
37062785	Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association	2023	ATF4-mediated circTDRD3 promotes gastric cancer cell proliferation and metastasis by regulating the miR-891b/ITGA2 axis and AKT signaling pathway.	hsa_circ_0003441	circTDRD3	hsa_circ_TDRD3	TDRD3	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; RNA-seq	"circTDRD3 (hsa_circ_0003441), derived from TDRD3, is up-regulated in gastric cancer tissues and cell lines and is associated with tumor size, lymph node metastasis, and poor prognosis. It promotes gastric cancer proliferation, migration, invasion, tumor growth, and lung metastasis by sponging miR-891b to increase ITGA2 expression and activate AKT signaling, while ATF4 further promotes TDRD3/circTDRD3 transcription in a positive feedback loop."	0.8981
37069371	"Journal of molecular medicine (Berlin, Germany)"	2023	The diagnostic potential of a circRNA-miRNA network in non-small cell lung cancer.	hsa_circ_0008167				non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0008167 was up-regulated in serum from NSCLC patients and showed diagnostic value for distinguishing NSCLC from benign lung tumor. Its higher serum level was associated with more malignant clinical features, including lymph node metastasis, distant metastasis, and higher tumor stage, and it was incorporated into a predicted circRNA-miRNA diagnostic network with hsa-miR-4482-3p and hsa-miR-146a-3p."	0.459
37069371	"Journal of molecular medicine (Berlin, Germany)"	2023	The diagnostic potential of a circRNA-miRNA network in non-small cell lung cancer.	hsa_circ_0003317				non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0003317 was up-regulated in serum from NSCLC patients and showed diagnostic value for distinguishing NSCLC from benign lung tumor, especially when combined with hsa_circ_0008167 or the selected miRNAs. Unlike hsa_circ_0008167, hsa_circ_0003317 was not significantly associated with the assessed clinicopathological parameters in NSCLC."	0.459
37073559	Autoimmunity	2023	Highly-expressed circ_0129657 inhibits proliferation as well as promotes apoptosis and inflammation in HBMECs after oxygen-glucose deprivation via miR-194-5p/GMFB axis.	hsa_circ_0129657	circ_0129657	hsa_circ_IQGAP2	IQGAP2	ischemic stroke	MONDO:1060198	ischemic stroke	up-regulated	RT-qPCR	"circ_0129657 is up-regulated in OGD-induced human brain microvascular endothelial cells and appears to aggravate stroke-related endothelial injury. Mechanistically, it sponges miR-194-5p to regulate GMFB, thereby inhibiting proliferation while promoting apoptosis, inflammatory factor secretion, cerebral infarction volume, and neurological impairment."	0.7624
37074418	Wiener klinische Wochenschrift	2023	CircRNA circSLIT2 is a novel diagnostic and prognostic biomarker for gastric cancer.		circSLIT2	hsa_circ_SLIT2	SLIT2	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR	"circSLIT2 is up-regulated in gastric cancer tissues and plasma, with plasma levels positively correlated with tumor-tissue levels. The study supports circSLIT2 as a diagnostic and prognostic biomarker for gastric cancer, with high expression associated with poorer survival and distant metastasis, but it did not experimentally define a molecular mechanism."	0.4992
37075641	"Pathology, research and practice"	2023	"Circ_RBM23 knockdown suppresses chemoresistance, proliferation, migration and invasion of sorafenib-resistant HCC cells through miR-338-3p/RAB1B axis."	hsa_circ_0000524	circ_RBM23	hsa_circ_RBM23	RBM23	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_RBM23 is up-regulated in sorafenib-resistant HCC tissues and cells. Its knockdown sensitizes resistant HCC cells to sorafenib, suppresses proliferation, migration and invasion, increases apoptosis, and delays xenograft tumor growth. Mechanistically, circ_RBM23 promotes sorafenib resistance and malignant phenotypes through the miR-338-3p/RAB1B axis."	0.8175
37075663	Veterinary microbiology	2023	Circular RNA circAKIRIN2 participates in the process of stress-induced immunosuppression affecting immune response to infectious bursal disease virus vaccine in chicken.		circAKIRIN2	gga_circ_akirin2	akirin2	stress-induced immunosuppression	MONDO:0000001	disease	dysregulated	RT-qPCR	"This study identified chicken circAKIRIN2 as a conserved circRNA derived from akirin2 and showed by qRT-PCR that its serum and tissue expression is altered during Dex-induced immunosuppression and IBDV vaccination. The authors conclude that circAKIRIN2 is involved in stress-induced immunosuppression affecting IBDV vaccine immunity, particularly during acquired immunity, with heart, liver and lung highlighted as important tissues. Bioinformatics prediction suggests a ceRNA mechanism involving candidate miRNAs and ZBTB20, but the targeting relationships remain unvalidated."	0.5202
37078141	Journal of gastroenterology and hepatology	2023	Circular RNA circTNIK promotes tumor progression and metastasis in gastric cancer by regulating ZEB2.	hsa_circ_0002387	circTNIK / circ_0002387	hsa_circ_TNIK	TNIK	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"circTNIK is a TNIK-derived circular RNA that is upregulated in gastric cancer tissues and cell lines, especially in metastatic disease. It promotes gastric cancer proliferation, invasion, tumorigenesis, and lung/liver metastasis by acting as a miR-138-5p sponge to increase ZEB2 expression. High circTNIK expression is associated with aggressive phenotypes and poor overall survival, suggesting prognostic value."	0.8912
37078361	The International journal of developmental biology	2023	Circ-JA760602 promotes the apoptosis of hypoxia-induced cardiomyocytes by transcriptionally suppressing BCL2.	hsa_circ_0089761	circ-JA760602	hsa_circ_JA760602	JA760602	acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR; Microarray	"Circ-JA760602 is up-regulated in AMI patient heart samples from GEO data and in hypoxia-treated human AC16 cardiomyocytes. It promotes hypoxia-induced cardiomyocyte apoptosis by binding EGR1 and E2F1 in the cytoplasm, preventing their nuclear translocation and reducing transcriptional activation of the anti-apoptotic gene BCL2."	0.8161
37079266	Molecular biotechnology	2024	Circular RNA Dipeptidyl Peptidase 4 (circDPP4) Stimulates the Expression of Glutamate Dehydrogenase 1 to Contribute to the Malignant Phenotypes of Prostate Cancer by Sponging miR-497-5p.	hsa_circ_0056881	circRNA dipeptidyl peptidase 4 / circ_0056881	hsa_circ_DPP4	DPP4	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"CircDPP4 is up-regulated in prostate cancer tissues and cell lines. It promotes PCa cell proliferation, growth, motility, invasion and xenograft tumorigenicity while suppressing apoptosis. Mechanistically, circDPP4 sponges miR-497-5p to increase GLUD1 expression, forming a circDPP4/miR-497-5p/GLUD1 regulatory axis and suggesting circDPP4 as a potential therapeutic target."	0.8299
37080266	Acta tropica	2023	Circular RNA ciRS-7 affects the propagation of Cryptosporidium parvum in HCT-8 cells via regulating miR-135a-5p/stat1 axis.		ciRS-7 / CDR1as			cryptosporidiosis	MONDO:0015474	cryptosporidiosis	up-regulated	Microarray	"ciRS-7 is an up-regulated host circRNA associated with C. parvum infection in HCT-8 cells. In this study, ciRS-7 promotes C. parvum propagation by sponging miR-135a-5p and positively regulating stat1/STAT1 expression and STAT1 phosphorylation, supporting a ceRNA-based mechanism and suggesting ciRS-7 as a potential therapeutic target for cryptosporidiosis."	0.5495
37084911	The Science of the total environment	2023	The regulation of circRNA_kif26b on alveolar epithelial cell senescence via miR-346-3p is involved in microplastics-induced lung injuries.	rno_circ_0008495	circRNA_kif26b	rno_circ_kif26b	kif26b	microplastic-induced lung injury	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR	"circ_kif26b is up-regulated in PS-MPs-exposed rat lung tissues and PS-MPs-treated MLE12 cells. It is mainly cytoplasmic and promotes alveolar epithelial cell senescence and inflammatory SASP secretion by sponging miR-346-3p to increase p21 expression, contributing to PS-MPs-induced lung inflammation/injury."	0.6683
37084911	The Science of the total environment	2023	The regulation of circRNA_kif26b on alveolar epithelial cell senescence via miR-346-3p is involved in microplastics-induced lung injuries.	mmu_circ_0008495	circRNA_kif26b	mmu_circ_kif26b	kif26b	microplastic-induced lung injury	MONDO:0015796	acute lung injury	up-regulated	RT-qPCR	"circ_kif26b is up-regulated in PS-MPs-exposed rat lung tissues and PS-MPs-treated MLE12 cells. It is mainly cytoplasmic and promotes alveolar epithelial cell senescence and inflammatory SASP secretion by sponging miR-346-3p to increase p21 expression, contributing to PS-MPs-induced lung inflammation/injury."	0.6683
37094855	Annals of clinical and laboratory science	2023	hsa_circ_0006916 Exerts Effect on Amyloid Beta-Induced Neuron Injury by Targeting miR-217/HOMER1.	hsa_circ_0006916	circHOMER1 / circ_0006916	hsa_circ_HOMER1	HOMER1	Alzheimer's disease / AD	MONDO:0004975	Alzheimer disease	down-regulated	RT-qPCR	"This study investigates hsa_circ_0006916/circHOMER1 in an Abeta-induced neuronal injury model relevant to Alzheimer's disease. CircHOMER1 is reduced by fAbeta42 treatment, and its overexpression improves SH-SY5Y cell viability and suppresses apoptosis by sponging miR-217 and regulating HOMER1. The work proposes the circHOMER1/miR-217/HOMER1 axis as a potential molecular mechanism for AD-related neuronal protection."	0.7164
37096071	Cellular and molecular bioengineering	2023	Circ_0004585 Facilitates Tumorigenesis of Colorectal Cancer Via Modulating the miR-338-3p/ZFX Axis and Activating the MEK/ERK Pathway.	hsa_circ_0004585	circ_0004585	hsa_circ_CEMIP		colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circ_0004585 is up-regulated in CRC tissues and cell lines and acts as an oncogenic circRNA. It promotes CRC proliferation, angiogenesis, EMT, migration and tumor growth while suppressing apoptosis, mainly by sponging miR-338-3p to regulate ZFX and activate the MEK/ERK pathway. The study suggests circ_0004585 may be a potential therapeutic target for CRC."	0.7899
37097437	Metabolic brain disease	2023	CircZfp609 contributes to cerebral infarction via sponging miR-145a-5p to regulate BACH1.	mmu_circ_0001797	circZfp609	mmu_circ_Zfp609	Zfp609	cerebral infarction	MONDO:0002679	cerebral infarction	up-regulated	RT-qPCR	"In this study, circZfp609 was up-regulated in MCAO mouse brain tissue and OGD/R-induced mouse astrocytes. circZfp609 promoted cerebral infarction-related brain injury and astrocyte injury by sponging miR-145a-5p and up-regulating BACH1, while circZfp609 knockdown reduced infarct volume, neurological deficit scores, apoptosis, inflammation and LDH release and improved astrocyte proliferation/viability."	0.7825
37099250	"Cellular oncology (Dordrecht, Netherlands)"	2023	Aberrant expression of circular RNA DHPR facilitates tumor growth and metastasis by regulating the RASGEF1B/RAS/MAPK axis in hepatocellular carcinoma.	hsa_circ_0069249	circDHPR	hsa_circ_DHPR	DHPR	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"circDHPR is downregulated in HCC and functions as a tumor suppressor. Its overexpression inhibits proliferation, invasion, migration, EMT, tumor growth and lung metastasis by sponging miR-3194-5p, upregulating RASGEF1B, and suppressing the Ras/MAPK pathway. Clinically, higher circDHPR expression is associated with better OS and DFS, suggesting prognostic and therapeutic potential."	0.8868
37099790	Pancreas	2022	Circ_0058058 Drives the Malignant Phenotypes and Immune Evasion of Pancreatic Cancer by the MicroRNA-557-Dependent Regulation of PDL1.	hsa_circ_0058058	hsa_circRNA_102913 / circ_0058058			Pancreatic cancer / PC	MONDO:0009831	malignant pancreatic neoplasm	up-regulated	RT-qPCR; Microarray	"Circ_0058058 is up-regulated in pancreatic cancer tissues and cell lines, and high expression is associated with poorer overall survival. Functionally, it promotes malignant phenotypes including proliferation, invasion, angiogenesis, immune escape, and tumor growth, while suppressing apoptosis. Mechanistically, circ_0058058 acts as a miR-557 sponge to increase PDL1 expression in pancreatic cancer."	0.8202
37100987	Journal of human hypertension	2023	CircHIPK2 facilitates phenotypic switching of vascular smooth muscle cells in hypertension.	hsa_circ_0001756	circHIPK2	hsa_circ_HIPK2	HIPK2	essential hypertension / EH	MONDO:0001134	essential hypertension	up-regulated	RT-qPCR; ISH	"circHIPK2 is a human HIPK2-derived circRNA that is upregulated in aortic VSMCs from hypertensive patients. It promotes AngII-induced VSMC phenotype switching by sponging miR-145-5p and increasing ADAM17 expression, thereby enhancing VSMC proliferation and suppressing apoptosis. The study suggests circHIPK2 as a potential therapeutic target for hypertension."	0.8203
37101770	European urology open science	2023	Circular RNA Ubiquitin-associated Protein 2 Silencing Suppresses Bladder Cancer Progression by Downregulating DNA Topoisomerase 2-alpha Through Sponging miR-496.	hsa_circ_0003141	circRNA ubiquitin-associated protein 2 / circUBAP2 / Circular RNA UBAP2	hsa_circ_UBAP2	UBAP2	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"circUBAP2 is up-regulated in bladder cancer and high expression is associated with poor overall survival and aggressive clinicopathological features. Functionally, circUBAP2 promotes BC cell proliferation, migration, invasion, aerobic glycolysis, and xenograft tumor growth while inhibiting apoptosis. Mechanistically, circUBAP2 acts as a ceRNA for miR-496 to up-regulate TOP2A."	0.8202
37114252	"Cellular and molecular biology (Noisy-le-Grand, France)"	2022	Circ-ABCC1 enhances radioresistance of breast cancer cells via miR-627-5p/ABCC1 axis.	hsa_circ_0003427	circ-ABCC1	hsa_circ_ABCC1	ABCC1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"hsa_circ_0003427, termed circ-ABCC1, is up-regulated in radio-resistant breast cancer cells. It promotes breast cancer cell radioresistance by sponging miR-627-5p and thereby increasing ABCC1 expression; circ-ABCC1 knockdown suppresses viability and proliferation and promotes apoptosis in radio-resistant BC cells."	0.6716
37121557	Cellular signalling	2023	CircKIF4A combines EIF4A3 to stabilize SDC1 expression to activate c-src/FAK and promotes TNBC progression.		Circular RNA KIF4A / circKIF4A	hsa_circ_KIF4A	KIF4A	Triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR	"circKIF4A is up-regulated in TNBC tissues and cell lines and acts as an oncogenic circRNA. It binds EIF4A3 to stabilize SDC1 mRNA, thereby increasing SDC1 expression and activating c-src/FAK signaling to promote TNBC cell proliferation, migration, invasion, EMT-related changes, and xenograft tumor growth."	0.8252
37127184	Life sciences	2023	EIF4A3-induced circZFAND6 promotes breast cancer proliferation and metastasis through the miR-647/FASN axis.	hsa_circ_0000643	circZFAND6	hsa_circ_ZFAND6	ZFAND6	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circZFAND6 is a human circRNA derived from ZFAND6 that is up-regulated in breast cancer tissues and cell lines. EIF4A3 promotes its expression, and circZFAND6 enhances breast cancer proliferation and metastasis by sponging miR-647 and increasing FASN expression. The study suggests circZFAND6 may represent a potential therapeutic target, although its clinical prognostic value was not established."	0.7415
37128800	"Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals"	2023	CircRNA CDR1as: a novel diagnostic and prognostic biomarker for gastric cancer.		CDR1as / CircRNA CDR1as	hsa_circ_CDR1	CDR1	gastric cancer / GC	MONDO:0001056	gastric cancer	dysregulated	RT-qPCR	"This study found that CDR1as is dysregulated in gastric cancer: it is downregulated in GC tissues and cell lines but upregulated in plasma and plasma exosomes. Tissue-derived CDR1as showed diagnostic value and independently predicted overall survival, with lower tissue expression associated with shorter survival. Proteomic and bioinformatic analyses suggested that CDR1as regulates GC-related biological processes through downstream proteins and pathways, including miRNA signaling networks, glycine/serine/threonine metabolism, and HSPE1."	0.6815
37129498	Journal of neurogenetics	2023	"Knockdown of circ_CLIP2 regulates the proliferation, metastasis and apoptosis of glioma cells through miR-641/EPHA3/STAT3 axis."		circ_CLIP2	hsa_circ_CLIP2	CLIP2	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR	"circ_CLIP2 is up-regulated in glioma tissues and glioma cell lines. It functions as an oncogenic circRNA by sponging miR-641, thereby increasing EPHA3 expression and STAT3 phosphorylation. Knockdown of circ_CLIP2 suppresses proliferation, migration and invasion and promotes apoptosis of glioma cells."	0.7032
37130193	Biotechnology & genetic engineering reviews	2024	"Hsa_circ_0057104, by competitive adsorption of miR-627-5p, mediates CCND2 expression to promote malignant proliferation and Warburg effect of colorectal cancer."	hsa_circ_0057104	circPDK1	hsa_circ_PDK1	PDK1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"hsa_circ_0057104/circPDK1 is up-regulated in colorectal cancer tissues and cell lines. It promotes CRC malignant phenotypes, including proliferation, invasion, migration and Warburg effect/glycolysis, while suppressing apoptosis. Mechanistically, circPDK1 acts through a ceRNA axis by sponging miR-627-5p to increase CCND2 expression, and its expression is associated with TNM stage and tumor size."	0.7936
37131898	Reports of biochemistry & molecular biology	2023	The Emerging Role of Circular RNA Homeodomain Interacting Protein Kinase 3 and Circular RNA 0046367 through Wnt/Beta-Catenin Pathway on the Pathogenesis of Nonalcoholic Steatohepatitis in Egyptian Patients.		Circ_HIPK3 / circRNA-homeodomain interacting protein kinase 3	hsa_circ_HIPK3	HIPK3	nonalcoholic steatohepatitis / NASH	MONDO:0007027	metabolic dysfunction-associated steatohepatitis	up-regulated	RT-qPCR	"circRNA-HIPK3 was upregulated in plasma from NASH patients compared with controls. The study proposes that circRNA-HIPK3 may sponge miRNA-29a and participate in NASH pathogenesis through reduced Wnt/beta-catenin signaling, making it a potential therapeutic target."	0.2995
37131898	Reports of biochemistry & molecular biology	2023	The Emerging Role of Circular RNA Homeodomain Interacting Protein Kinase 3 and Circular RNA 0046367 through Wnt/Beta-Catenin Pathway on the Pathogenesis of Nonalcoholic Steatohepatitis in Egyptian Patients.	hsa_circ_0046367	circRNA-0046367			nonalcoholic steatohepatitis / NASH	MONDO:0007027	metabolic dysfunction-associated steatohepatitis	down-regulated	RT-qPCR	"circRNA-0046367 was downregulated in plasma from NASH patients compared with controls. The study proposes that circRNA-0046367 may sponge miRNA-34a and participate in NASH pathogenesis through altered Wnt/beta-catenin signaling, making it a potential therapeutic target."	0.2995
37132942	Molecular carcinogenesis	2023	Hsa_circ_0088036 promotes nonsmall cell lung cancer progression by regulating miR-1343-3p/Bcl-3 axis through TGFbeta/Smad3/EMT signaling.	hsa_circ_0088036	hsa_circ_104871	hsa_circ_SUSD1	SUSD1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0088036 is upregulated in NSCLC tissues and cell lines and is associated with tumor size, TNM stage, diagnostic value, and poor prognosis. Functionally, it promotes proliferation, migration, invasion, EMT, and xenograft tumor growth while inhibiting apoptosis. Mechanistically, it acts as a ceRNA sponge for miR-1343-3p, upregulates Bcl-3, and activates the TGFbeta/Smad3/EMT signaling pathway."	0.8508
37142816	Current medical science	2023	ARID1A Inactivation Increases Expression of circ0008399 and Promotes Cisplatin Resistance in Bladder Cancer.	hsa_circ_0008399	circ0008399 / circular RNA 0008399	hsa_circ_RBM3	RBM3	bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"In ARID1A-deficient bladder cancer cells, circ0008399 is up-regulated through an HDAC1/H4Ac/BRD4/EIF4A3-related epigenetic mechanism. Increased circ0008399 inhibits CDDP-induced apoptosis and promotes cisplatin resistance, while circ0008399 knockdown or EIF4A3 inhibition restores chemosensitivity."	0.5554
37146711	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association	2023	Comprehensive analysis and identification of the circ_0084615/miR-451a/MEF2D axis in benzo(a)pyrene exposed tumor cells in hepato-carcinogenesis.	hsa_circ_0084615	circ_0084615			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	circ_0084615 is up-regulated in B[a]P-treated liver cancer cells and localizes to the cytoplasm. The study supports a circ_0084615/miR-451a/MEF2D regulatory axis that may contribute to B[a]P-associated hepatocarcinogenesis.	0.7006
37146711	Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association	2023	Comprehensive analysis and identification of the circ_0084615/miR-451a/MEF2D axis in benzo(a)pyrene exposed tumor cells in hepato-carcinogenesis.	hsa_circ_0075320	circ_0075320			hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circ_0075320 is up-regulated in B[a]P-treated liver cancer cells and was validated as a circular, cytoplasmic RNA with AGO2 enrichment. The study proposes that circ_0075320 may act as a miRNA sponge and a key RNA associated with liver cancer metastasis, although a complete downstream mRNA axis was not experimentally established for this circRNA."	0.5215
37148331	Biochemical genetics	2023	"A Novel circ_0104345/miR-876-3p/ZBTB20 Axis Regulates the Proliferation, Migration, Invasion, and Apoptosis of Breast Cancer Cells."	hsa_circ_0104345	circ_0104345	hsa_circ_IQCH	IQCH	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"Circ_0104345 is up-regulated in breast cancer tissues and cells and functions as an oncogenic circRNA. Mechanistically, cytoplasmic circ_0104345 sponges miR-876-3p to regulate ZBTB20 expression, thereby promoting proliferation, migration, invasion, angiogenesis and tumor growth while suppressing apoptosis."	0.8175
37153995	Shanghai kou qiang yi xue = Shanghai journal of stomatology	2023	[Effect of circRASA2 targeting miR-543/TRAF6 axis on LPS-induced periodontal ligament cell proliferation and osteogenic differentiation].	hsa_circ_0067582	circRASA2	hsa_circ_RASA2	RASA2	periodontitis	MONDO:0005076	periodontitis	up-regulated	RT-qPCR	"In an LPS-induced human PDLC periodontitis model, circRASA2 was up-regulated and promoted pathological injury. Silencing circRASA2 increased PDLC proliferation, migration and osteogenic differentiation, apparently by releasing miR-543 and reducing TRAF6 expression. The study suggests circRASA2 as a potential therapeutic target for periodontitis."	0.5554
37154070	"Shock (Augusta, Ga.)"	2023	CIRC_0001818 TARGETS MIR-136-5P TO INCREASE LIPOPOLYSACCHARIDE-INDUCED HK2 CELL INJURIES BY ACTIVATING TXNIP/NLRP3 INFLAMMASOME PATHWAY.	hsa_circ_0001818	circ_0001818 / circRNA_104670	hsa_circ_UBR5	UBR5	septic acute kidney injury	MONDO:0002492	acute kidney injury	up-regulated	RT-qPCR	"circ_0001818 is up-regulated in LPS-treated HK2 septic AKI cell models and in serum-derived exosomes from sepsis/septic AKI patients. Functionally, circ_0001818 promotes LPS-induced renal tubular epithelial cell injury, including cell death, oxidative stress, inflammatory cytokine secretion and NLRP3 inflammasome activation, by sponging miR-136-5p and increasing TXNIP expression. Exosomal circ_0001818 also shows diagnostic biomarker potential for septic AKI."	0.8562
37158446	Journal of biochemical and molecular toxicology	2023	Knockdown of circMFN2 inhibits cell progression and glycolysis by miR-198/CUL4B pathway in ovarian cancer.	hsa_circ_0009910	circRNA mitofusin 2 / circMFN2	hsa_circ_MFN2	MFN2	ovarian cancer / OC	MONDO:0008170	ovarian cancer	up-regulated	RT-qPCR	"circMFN2 is upregulated in ovarian cancer tissues and cells and is associated with poorer survival. Functionally, circMFN2 promotes OC cell proliferation, migration, invasion, glycolysis, and in vivo tumor growth while inhibiting apoptosis. Mechanistically, circMFN2 acts through the miR-198/CUL4B axis."	0.8427
37158456	Carcinogenesis	2023	METTL9 derived circular RNA circ-METTL9 sponges miR-551b-5p to accelerate colorectal cancer progression by upregulating CDK6.	hsa_circ_0002696	circ-METTL9	hsa_circ_METTL9	METTL9	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; RNA-seq	"circ-METTL9 is a METTL9-derived circular RNA upregulated in colorectal cancer tissues and associated with advanced disease and shorter overall survival. Functionally, it promotes CRC proliferation, migration, invasion, tumor growth and metastasis. Mechanistically, circ-METTL9 acts as a miR-551b-5p sponge to increase CDK6 expression through the circ-METTL9/miR-551b-5p/CDK6 axis."	0.8904
37158505	Histology and histopathology	2024	CircRTTN upregulates EPHA2 to aggravate the malignant process of melanoma via sponging miR-890.	hsa_circ_0108830	CircRTTN	hsa_circ_RTTN	RTTN	melanoma	MONDO:0005105	melanoma	up-regulated	RT-qPCR	"CircRTTN/hsa_circ_0108830 is an up-regulated human circRNA derived from RTTN in melanoma tissues and cell lines. It promotes melanoma malignant behaviors including proliferation, migration, invasion, angiogenesis and tumor growth, while suppressing apoptosis. Mechanistically, circRTTN sponges miR-890 to increase EPHA2 expression, forming a circRTTN/miR-890/EPHA2 regulatory axis."	0.8443
37161917	Biological chemistry	2024	Mechanism of hypoxia-induced exosome circ_0051799 regulating the progression of lung adenocarcinoma.	hsa_circ_0051799	circ_0051799			lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; ISH; Microarray	"hsa_circ_0051799 is up-regulated in LUAD tissues, LUAD cells, and hypoxia-induced EVs. It promotes LUAD proliferation, invasion, metastasis, EMT, and TAM M2 polarization while inhibiting apoptosis, mainly through an exosomal circ_0051799/miR-214-3p/IGF2BP3 axis that activates the JAK/STAT3 pathway."	0.8686
37164546	Cellular signalling	2023	Circular RNA circSEMA5A facilitates colorectal cancer development by regulating microRNA-195-5p to target CCNE1 axis.	hsa_circ_0071803	circ_0071803 / circSEMA5A	hsa_circ_SEMA5A	SEMA5A	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circSEMA5A is up-regulated in CRC cells and functions as an oncogenic circRNA. It promotes proliferation, migration, invasion and xenograft tumor growth by sponging miR-195-5p and increasing CCNE1 expression, suggesting potential relevance for CRC targeted therapy."	0.8354
37164696	The Tohoku journal of experimental medicine	2023	CircRNA CircABCB1 Diminishes the Sensitivity of Breast Cancer Cells to Docetaxel by Sponging MiR-153-3p.		CircABCB1	hsa_circ_ABCB1		breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"CircABCB1 is up-regulated in breast cancer, particularly in docetaxel-resistant breast cancer tissues and cells. Functionally, circABCB1 promotes docetaxel resistance, viability, migration and invasion while inhibiting apoptosis, at least partly by sponging miR-153-3p. Clinically, high circABCB1 expression is associated with metastasis and poorer time to treatment failure, suggesting value as a marker of docetaxel resistance."	0.7752
37166618	Cell stress & chaperones	2023	CircRNA7632 down-regulation alleviates endothelial cell dysfunction in Kawasaki disease via regulating IL-33 expression.		CircRNA7632 / circ7632			Kawasaki disease / KD	MONDO:0012727	Kawasaki disease	up-regulated	RT-qPCR; RNA-seq	"This study found that circ7632 is up-regulated in HUVECs exposed to Kawasaki disease serum. Functional experiments indicate that circ7632 promotes EndoMT, while circ7632 knockdown alleviates KD serum-induced EndoMT and migration, likely by decreasing IL-33 expression. The authors propose circ7632 as a potential therapeutic target for KD-associated endothelial dysfunction."	0.5979
37169142	European journal of pharmacology	2023	Detailed profiling of m6A modified circRNAs and synergistic effects of circRNA and environmental risk factors for coronary artery disease.			hsa_circ_HECTD1	HECTD1	coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR; RNA-seq	"hsa_circHECTD1 is an m6A-modified circRNA derived from HECTD1 and is significantly up-regulated in ox-LDL-treated HCASMCs and PBMCs from CAD patients. The study supports its potential clinical value as a CAD diagnostic biomarker and shows a positive interaction with hypertension in increasing CAD risk, although its detailed molecular mechanism was not functionally demonstrated."	0.729
37169142	European journal of pharmacology	2023	Detailed profiling of m6A modified circRNAs and synergistic effects of circRNA and environmental risk factors for coronary artery disease.			hsa_circ_ZBTB46	ZBTB46	coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	up-regulated	RT-qPCR; RNA-seq	"hsa_circZBTB46 is an m6A-modified circRNA derived from ZBTB46 and is significantly up-regulated in ox-LDL-treated HCASMCs and PBMCs from CAD patients. Its elevated expression was associated with higher CAD incidence after adjustment for cardiovascular risk factors, and it showed diagnostic biomarker potential and a synergistic risk-enhancing interaction with hypertension."	0.729
37173390	Cell death and differentiation	2023	Circular RNA circRILPL1 promotes nasopharyngeal carcinoma malignant progression by activating the Hippo-YAP signaling pathway.	hsa_circ_0007552	circRILPL1	hsa_circ_RILPL1	RILPL1	nasopharyngeal carcinoma / NPC	MONDO:0015459	nasopharyngeal carcinoma	up-regulated	RT-qPCR; ISH; RNA-seq	"circRILPL1 is up-regulated in nasopharyngeal carcinoma and high expression is associated with poorer overall survival. Functionally, it promotes NPC proliferation, invasion, migration, and metastasis in vitro and in vivo. Mechanistically, circRILPL1 binds ROCK1 and IPO7 to activate Hippo-YAP signaling, stabilize and nuclear-translocate YAP, and enhance CAPN2 and PXN transcription."	0.8995
37179246	"Shock (Augusta, Ga.)"	2023	CIRC_0026466 KNOCKDOWN PROTECTS HUMAN BRONCHIAL EPITHELIAL CELLS FROM CIGARETTE SMOKE EXTRACT-INDUCED INJURY BY PROMOTING THE MIR-153-3P/TRAF6/NF-kappaB PATHWAY.	hsa_circ_0026466	circ_0026466			chronic obstructive pulmonary disease / COPD	MONDO:0005002	chronic obstructive pulmonary disease	up-regulated	RT-qPCR	"circ_0026466 is up-regulated in blood and BALF from COPD patients and in CSE-induced 16HBE cells. Its knockdown protects bronchial epithelial cells from CSE-induced injury by promoting viability/proliferation and reducing apoptosis, inflammatory cytokine production, and oxidative stress. Mechanistically, circ_0026466 functions through the miR-153-3p/TRAF6 axis to regulate NF-kappaB pathway activation and may have diagnostic and therapeutic relevance in COPD."	0.8001
37183944	Critical reviews in eukaryotic gene expression	2023	hsa_circ_0051428 Facilitates the Progression of Thyroid Cancer by Sponging miR-1248 to Up-Regulate FN1.	hsa_circ_0051428	circ_0051428 / circRNA_102566	hsa_circ_RELB	RELB	thyroid cancer / TC	MONDO:0002108	thyroid cancer	up-regulated	RT-qPCR	"circ_0051428 is upregulated in thyroid cancer and acts as an oncogenic circRNA. It promotes proliferation, migration, colony formation, and tumor growth while suppressing apoptosis, at least in part through the circ_0051428/miR-1248/FN1 axis."	0.6996
37187949	Cytotechnology	2023	Targeting a novel circITCH/miR-421/BTG1 axis is effective to suppress the malignant phenotypes in hepatocellular carcinoma (HCC) cells.		circITCH / circular RNA itchy E3 ubiquitin protein ligase	hsa_circ_ITCH	ITCH	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR	"circITCH is down-regulated in HCC tissues and cell lines and acts as a tumor suppressor. It inhibits proliferation and colony formation, induces apoptosis and G1/S cell cycle arrest, and functions through a circITCH/miR-421/BTG1 ceRNA axis. Lower circITCH expression is associated with larger tumor size and higher TNM stage, indicating potential clinical relevance in HCC progression."	0.7045
37193942	Biochemical genetics	2023	Circular circRANGAP1 Contributes to Non-small Cell Lung Cancer Progression by Increasing COL11A1 Expression Through Sponging miR-653-5p.	hsa_circ_0063526	circRAN-GAP1	hsa_circ_RANGAP1	RANGAP1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circRANGAP1 is up-regulated in NSCLC tissues and cell lines, and high expression is associated with poorer patient survival. Functionally, circRANGAP1 promotes NSCLC proliferation, migration, invasion, EMT, and xenograft tumor growth. Mechanistically, it acts as a miR-653-5p sponge to increase COL11A1 expression through a circRANGAP1/miR-653-5p/COL11A1 ceRNA axis."	0.798
37194934	Protein and peptide letters	2023	CircPSMC3 Inhibits Colorectal Cancer Cell Growth and Migration by Controlling miR-31-5p/YAP/beta-Catenin.		CircPSMC3	hsa_circ_PSMC3	PSMC3	Colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"CircPSMC3 is down-regulated in colorectal cancer tissues and cell lines. Its overexpression suppresses CRC cell proliferation, invasion and migration by sponging miR-31-5p and modulating the YAP/beta-catenin axis, suggesting potential therapeutic relevance."	0.6536
37201873	Genomics	2023	"Hsa_circ_0002019 promotes cell proliferation, migration, and invasion by regulating TNFAIP6/NF-kappaB signaling in gastric cancer."	hsa_circ_0002019	circ_0002019	hsa_circ_FOXRED1	FOXRED1	gastric cancer / GC	MONDO:0001056	gastric cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0002019 is up-regulated in gastric cancer tissues and cells and is associated with metastatic GC tissue. It promotes GC proliferation, migration, invasion, EMT and tumor growth by binding PTBP1, increasing TNFAIP6 mRNA stability, and activating TNFAIP6/NF-kappaB signaling. Silencing circ_0002019 suppresses malignant phenotypes in vitro and inhibits xenograft tumor growth in vivo."	0.835
37202649	Molecular biotechnology	2024	Circular RNA AGAP1 Stimulates Immune Escape and Distant Metastasis in Renal Cell Carcinoma.	hsa_circ_0058792	circAGAP1	hsa_circ_AGAP1	AGAP1	clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR	"circAGAP1 is up-regulated in ccRCC and is associated with higher histological grade, distant metastasis, and poorer survival. Functionally, circAGAP1 promotes proliferation, invasion, migration, EMT, tumor growth, metastasis, and immune escape, mainly through the circAGAP1/miR-216a-3p/MKNK2 ceRNA axis."	0.8535
37208938	Liver international : official journal of the International Association for the Study of the Liver	2023	A circular RNA produced by LRBA promotes cirrhotic mouse liver regeneration through facilitating the ubiquitination degradation of p27.		circLRBA	hsa_circ_LRBA	LRBA	liver fibrosis	MONDO:0005155	cirrhosis of liver	down-regulated	RT-qPCR	"circLRBA is an LRBA-derived circRNA that is down-regulated in cirrhotic liver tissues but up-regulated during liver regeneration after partial hepatectomy. It promotes cirrhotic liver regeneration by acting as a scaffold for RNF123 and p27, facilitating ubiquitination-dependent p27 degradation and thereby enhancing cell-cycle progression, hepatocyte proliferation, liver metabolism and inflammatory resistance. Clinically, higher baseline circLRBA levels in non-tumorous liver tissue are associated with lower perioperative total bilirubin levels."	0.8972
37208938	Liver international : official journal of the International Association for the Study of the Liver	2023	A circular RNA produced by LRBA promotes cirrhotic mouse liver regeneration through facilitating the ubiquitination degradation of p27.	mmu_circ_0010831	circLRBA	mmu_circ_LRBA	LRBA	liver fibrosis	MONDO:0005155	cirrhosis of liver	down-regulated	RT-qPCR	"circLRBA is an LRBA-derived circRNA that is down-regulated in cirrhotic liver tissues but up-regulated during liver regeneration after partial hepatectomy. It promotes cirrhotic liver regeneration by acting as a scaffold for RNF123 and p27, facilitating ubiquitination-dependent p27 degradation and thereby enhancing cell-cycle progression, hepatocyte proliferation, liver metabolism and inflammatory resistance. Clinically, higher baseline circLRBA levels in non-tumorous liver tissue are associated with lower perioperative total bilirubin levels."	0.8972
37208963	Cell biology international	2023	"Circular RNA hsa_circ_0005239 contributes to hepatocellular carcinoma cell migration, invasion, and angiogenesis by targeting the miR-34a-5p/PD-L1 axis."	hsa_circ_0005239	circGFRA1	hsa_circ_GFRA1	GFRA1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"hsa_circ_0005239 is upregulated in HCC tissues and cell lines and functions as an oncogenic circRNA. It promotes HCC migration, invasion, angiogenesis, and xenograft growth by sponging miR-34a-5p, increasing PD-L1 expression, and activating the PI3K/Akt pathway. The study suggests hsa_circ_0005239 may serve as a potential diagnostic biomarker and therapeutic target for HCC."	0.6815
37211508	Archives of medical research	2023	Hsa_circ_0111738 Inhibits Tumor Progression and Angiogenesis in Multiple Myeloma by Sponging miR-1233-3p to Regulate HIF-1 Signaling Pathway.	hsa_circ_0111738	circ_0111738	hsa_circ_SOC13	SOC13	multiple myeloma / MM	MONDO:0009693	plasma cell myeloma	down-regulated	RT-qPCR	"hsa_circ_0111738 is downregulated in multiple myeloma tissues, bone marrow aspirates and MM cell lines. Functionally, its overexpression suppresses MM cell proliferation, migration, invasion, angiogenesis and xenograft tumor growth, and promotes apoptosis. Mechanistically, it acts as a ceRNA sponge for miR-1233-3p and attenuates HIF-1 signaling, suggesting potential diagnostic or therapeutic relevance in MM."	0.817
37212178	Journal of periodontal research	2023	Circular RNA hsa_circ_0084054 promotes the progression of periodontitis with diabetes via the miR-508-3p/PTEN axis.	hsa_circ_0084054		hsa_circ_ADAM32	ADAM32	periodontitis	MONDO:0005076	periodontitis	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0084054 is up-regulated in high glucose plus P. gingivalis LPS-treated PDLCs and in PDL tissues from patients with diabetic periodontitis. It promotes diabetic periodontitis progression by sponging miR-508-3p, increasing PTEN expression, inhibiting PI3K/AKT signaling, and aggravating inflammation, oxidative stress and apoptosis."	0.8284
37218166	Analytical chemistry	2023	Construction of Genetically Encoded Light-Up RNA Aptamers for Label-free and Ultrasensitive Detection of CircRNAs in Cancer Cells and Tissues.		circRNA mitochondrial tRNA translation optimization 1 (circMTO1) / circMTO1	hsa_circ_MTO1	MTO1	breast cancer	MONDO:0007254	breast cancer	dysregulated	RT-qPCR	"This study used circMTO1 as the model target to develop and validate a label-free ultrasensitive fluorescent biosensor. Endogenous circMTO1 was dysregulated across tested human cancer cell lines and was down-regulated in breast cancer patient tissues compared with healthy tissues, supporting its potential clinical utility as a cancer-related biomarker."	0.2995
37218166	Analytical chemistry	2023	Construction of Genetically Encoded Light-Up RNA Aptamers for Label-free and Ultrasensitive Detection of CircRNAs in Cancer Cells and Tissues.		circRNA mitochondrial tRNA translation optimization 1 (circMTO1) / circMTO1	hsa_circ_MTO1	MTO1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	dysregulated	RT-qPCR	"This study used circMTO1 as the model target to develop and validate a label-free ultrasensitive fluorescent biosensor. Endogenous circMTO1 was dysregulated across tested human cancer cell lines and was down-regulated in breast cancer patient tissues compared with healthy tissues, supporting its potential clinical utility as a cancer-related biomarker."	0.2995
37218166	Analytical chemistry	2023	Construction of Genetically Encoded Light-Up RNA Aptamers for Label-free and Ultrasensitive Detection of CircRNAs in Cancer Cells and Tissues.		circRNA mitochondrial tRNA translation optimization 1 (circMTO1) / circMTO1	hsa_circ_MTO1	MTO1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	dysregulated	RT-qPCR	"This study used circMTO1 as the model target to develop and validate a label-free ultrasensitive fluorescent biosensor. Endogenous circMTO1 was dysregulated across tested human cancer cell lines and was down-regulated in breast cancer patient tissues compared with healthy tissues, supporting its potential clinical utility as a cancer-related biomarker."	0.2995
37218166	Analytical chemistry	2023	Construction of Genetically Encoded Light-Up RNA Aptamers for Label-free and Ultrasensitive Detection of CircRNAs in Cancer Cells and Tissues.		circRNA mitochondrial tRNA translation optimization 1 (circMTO1) / circMTO1	hsa_circ_MTO1	MTO1	cervical cancer / CC	MONDO:0002974	cervical cancer	dysregulated	RT-qPCR	"This study used circMTO1 as the model target to develop and validate a label-free ultrasensitive fluorescent biosensor. Endogenous circMTO1 was dysregulated across tested human cancer cell lines and was down-regulated in breast cancer patient tissues compared with healthy tissues, supporting its potential clinical utility as a cancer-related biomarker."	0.2995
37219914	DNA and cell biology	2023	The Novel Circular RNA circTRIO Silence Inhibits the Progression of Laryngeal Squamous Cell Carcinoma.	hsa_circ_0005260	circTRIO	hsa_circ_TRIO	TRIO	laryngeal squamous cell carcinoma / LSCC	MONDO:0005595	laryngeal squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"circTRIO (hsa_circ_0005260), derived from TRIO and localized mainly in the cytoplasm, is up-regulated in LSCC tissues and cell lines. Its knockdown inhibits LSCC proliferation, colony formation and migration while promoting apoptosis, and high expression is associated with worse disease-free survival and malignant clinicopathological features. The study proposes circTRIO as a potential oncogenic biomarker and therapeutic target, with predicted miRNA sponge interactions involving miR-432-5p and miR-370-3p."	0.7886
37220402	Acta biochimica Polonica	2023	Circular RNA-AnnexinA7 accelerates cisplatin resistance in non-small cell lung cancer via modulating microRNA-545-3p to mediate Cyclin D1.		circular RNA (circRNA)-AnnexinA7 (ANXA7) / circ-ANXA7	hsa_circ_ANXA7	ANXA7	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"Circ-ANXA7 is up-regulated in DDP-resistant NSCLC tissues and cells and high expression is associated with poor overall survival. It promotes NSCLC progression and cisplatin resistance by sponging miR-545-3p to regulate CCND1, increasing proliferation, migration, invasion and resistance while suppressing apoptosis. Knockdown of circ-ANXA7 enhances DDP sensitivity and reduces xenograft tumor growth."	0.8442
37222950	Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico	2023	Induction of perineural invasion in salivary adenoid cystic carcinoma by circular RNA RNF111.		circ-RNF111 / CircRNA ring finger protein 111	hsa_circ_RNF111	RNF111	salivary adenoid cystic carcinoma / SACC	MONDO:0003175	salivary gland adenoid cystic carcinoma	up-regulated	RT-qPCR	"circ-RNF111 is up-regulated in SACC specimens and SACC cell lines and is mainly cytoplasmic. It promotes SACC-LM cell growth, migration, invasion, and perineural invasion by sponging miR-361-5p and increasing HMGB2 expression. High circ-RNF111 expression is associated with adverse clinicopathological features, poor survival, and diagnostic potential in SACC."	0.8659
37227723	Environmental toxicology	2023	CircKDM1B promotes hepatocellular carcinoma progression through regulating miR-1322/PRC1 axis.	hsa_circ_0075792	circKDM1B	hsa_circ_KDM1B	KDM1B	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circKDM1B is up-regulated in HCC tissues and cells and is associated with advanced tumor stage and poor overall survival. It promotes HCC progression by enhancing proliferation, migration, invasion and in vivo tumor growth while suppressing apoptosis. Mechanistically, circKDM1B acts as a miR-1322 sponge to increase PRC1 expression, forming the circKDM1B/miR-1322/PRC1 regulatory axis."	0.8557
37248151	Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association	2024	CircBBS9 accelerates the malignant progression of osteosarcoma through sponging miR-485-3p/HMGB1 axis.		circBBS9	hsa_circ_BBS9	BBS9	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR	"circBBS9 is up-regulated in osteosarcoma tissues and cell lines, and high expression is associated with poor prognosis. Functionally, circBBS9 promotes osteosarcoma proliferation, migration, invasion, EMT and xenograft tumor growth while suppressing apoptosis. Mechanistically, cytoplasmic circBBS9 sponges miR-485-3p to regulate HMGB1 expression through a circBBS9/miR-485-3p/HMGB1 ceRNA axis."	0.8711
37256441	Biochemical genetics	2024	The Circular RNA circFOXK2 Enhances the Tumorigenesis of Non-Small Cell Lung Cancer Through the miR-149-3p/IL-6 Axis.		circFOXK2	hsa_circ_FOXK2	FOXK2	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR; Microarray	"circFOXK2 is up-regulated in NSCLC tissues and cell lines. It promotes NSCLC proliferation, migration, invasion, and in vivo tumor growth by sponging miR-149-3p and increasing IL-6 expression through the circFOXK2/miR-149-3p/IL-6 axis."	0.6835
37258120	International heart journal	2023	"Regulation of a Novel CircTRRAP/miR-761/MAP3K2 CeRNA Cascade in Inflammation, Apoptosis, and Oxidative Stress in Human AC16 Cardiomyocytes under Hypoxia Conditions."	hsa_circ_0081241	circTRRAP	hsa_circ_TRRAP	TRRAP	acute myocardial infarction / AMI	MONDO:0004781	acute myocardial infarction	up-regulated	RT-qPCR	"circTRRAP is a TRRAP-derived human circRNA that is upregulated in AMI patient serum and hypoxia-exposed AC16 cardiomyocytes. Functionally, circTRRAP promotes hypoxia-induced cardiomyocyte injury, including reduced viability/proliferation and increased apoptosis, inflammation, and oxidative stress. Mechanistically, it acts as a ceRNA for miR-761 to post-transcriptionally regulate MAP3K2, and its serum upregulation may have diagnostic relevance for AMI."	0.8275
37269228	Cell biology international	2023	Paclitaxel inhibits hepatocellular carcinoma tumorigenesis by regulating the circ_0005785/miR-640/GSK3beta.	hsa_circ_0005785	circ_0005785	hsa_circ_ANAPC7	ANAPC7	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0005785 is up-regulated in HCC tissues and cell lines and is reduced by paclitaxel treatment. Its knockdown enhances paclitaxel sensitivity by suppressing proliferation, migration, invasion, angiogenesis and xenograft tumor growth while promoting apoptosis. Mechanistically, circ_0005785 functions as a miR-640 sponge to regulate GSK3beta expression."	0.7951
37272581	"Hematology (Amsterdam, Netherlands)"	2023	CircPLXNB2 regulates acute myeloid leukemia progression through miR-654-3p/CCND1 axis.	hsa_circ_0001257	circRNA Plexin B2 / circPLXNB2	hsa_circ_PLXNB2	PLXNB2	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR	"circPLXNB2 is upregulated in AML and promotes leukemic cell proliferation and cell-cycle progression while inhibiting apoptosis. It functions as a ceRNA that sponges miR-654-3p, thereby relieving repression of CCND1 and promoting AML progression."	0.7416
37276868	Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme	2023	Hsa_Circ_0104206 is An Oncogenic circRNA in Colon Cancer by Targeting Mir-188-3p/CCNA2 Axis.	hsa_circ_0104206	circ_0104206	hsa_circ_CSNK1G1	CSNK1G1	colon cancer	MONDO:0021063	malignant colon neoplasm	up-regulated	RT-qPCR	"Circ_0104206 is up-regulated in colon cancer tissues and cell lines. It acts as an oncogenic circRNA that promotes CC cell proliferation, colony formation, migration, and xenograft tumor growth, at least partly through the miR-188-3p/CCNA2 regulatory axis."	0.7795
37284894	Biochemical genetics	2024	"Circ_0059457 Promotes Proliferation, Metastasis, Sphere Formation and Glycolysis in Breast Cancer Cells by Sponging miR-140-3p to Regulate UBE2C."	hsa_circ_0059457	circ_0059457	hsa_circ_TASP1	TASP1	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR; Microarray	"circ_0059457 is up-regulated in breast cancer tissues and cells and promotes malignant progression. Mechanistically, it sponges miR-140-3p to regulate UBE2C, thereby promoting proliferation, migration, invasion, sphere formation, glycolysis, EMT-related changes, and xenograft tumor growth. The study proposes circ_0059457 as a potential therapeutic target for breast cancer."	0.8399
37286092	Preventive medicine	2023	Circ_ATAD3B inhibits cell proliferation of breast cancer via mediating the miR-570-3p/MX2 axis.		circ_ATAD3B	hsa_circ_ATAD3B	ATAD3B	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; Microarray	"circ_ATAD3B is down-regulated in breast cancer tissues and cell lines and acts as a tumor suppressor. It sponges miR-570-3p to increase MX2 expression, thereby inhibiting breast cancer cell viability and proliferation, and shows potential diagnostic and therapeutic biomarker value."	0.7759
37286166	Annals of hepatology	2023	Circular RNA hsa_circ_0098181 inhibits metastasis in hepatocellular carcinoma by activating the Hippo signaling pathway via interaction with eEF2.	hsa_circ_0098181		hsa_circ_SOX5	SOX5	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0098181 is down-regulated in HCC and low expression is linked to metastatic features and poor prognosis. Functionally, it suppresses migration, invasion and metastasis by sequestering eEF2, preventing F-actin formation and activating Hippo signaling; QKI-5 promotes its biogenesis."	0.8668
37286166	Annals of hepatology	2023	Circular RNA hsa_circ_0098181 inhibits metastasis in hepatocellular carcinoma by activating the Hippo signaling pathway via interaction with eEF2.	hsa_circ_0001020		hsa_circ_UGP2	UGP2	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0001020 is down-regulated in HCC tissues compared with adjacent non-tumorous tissues. Lower expression was associated with shorter overall survival, but no disease mechanism or biological function was further characterized in this study."	0.6841
37286166	Annals of hepatology	2023	Circular RNA hsa_circ_0098181 inhibits metastasis in hepatocellular carcinoma by activating the Hippo signaling pathway via interaction with eEF2.	hsa_circ_0001387		hsa_circ_WHSC1	WHSC1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0001387 is up-regulated in HCC tissues compared with adjacent non-tumorous tissues. The study confirmed its circular characteristics, but it was not correlated with DFS or OS and no mechanism or functional role was pursued."	0.6841
37286166	Annals of hepatology	2023	Circular RNA hsa_circ_0098181 inhibits metastasis in hepatocellular carcinoma by activating the Hippo signaling pathway via interaction with eEF2.	hsa_circ_0006633		hsa_circ_FGGY	FGGY	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0006633 is down-regulated in HCC tissues compared with adjacent non-tumorous tissues. The study confirmed its circular characteristics, but it was not correlated with DFS or OS and no mechanism or functional role was pursued."	0.6841
37291912	Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences	2023	[Effects of titanium dioxide nanoparticles on circRNA expression profiles in human hepatocellular carcinoma cells HepG2].		circRNA_7630			nanoparticles-induced hepatotoxicity	MONDO:0005359	drug-induced liver injury	down-regulated	RT-qPCR; RNA-seq	"circRNA_7630 was down-regulated in HepG2 cells after TiO2 nanoparticles exposure. The study linked circRNA_7630 to fatty acid degradation and fatty acid metabolism, suggesting a possible role in impaired mitochondrial energy production during hepatotoxicity."	0.2465
37291912	Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences	2023	[Effects of titanium dioxide nanoparticles on circRNA expression profiles in human hepatocellular carcinoma cells HepG2].		circRNA_3760			nanoparticles-induced hepatotoxicity	MONDO:0005359	drug-induced liver injury	down-regulated	RT-qPCR; RNA-seq	"circRNA_3760 was down-regulated in HepG2 cells exposed to TiO2 nanoparticles. The study associated circRNA_3760 with the Fanconi anemia pathway, suggesting a possible connection with impaired DNA repair and TiO2 nanoparticle-induced genotoxicity."	0.2465
37291912	Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences	2023	[Effects of titanium dioxide nanoparticles on circRNA expression profiles in human hepatocellular carcinoma cells HepG2].		circRNA_1521			nanoparticles-induced hepatotoxicity	MONDO:0005359	drug-induced liver injury	down-regulated	RT-qPCR; RNA-seq	circRNA_1521 was down-regulated in HepG2 cells after TiO2 nanoparticles exposure. The authors suggested that circRNA_1521 may be related to transcriptional regulation and DNA-binding transcription factor activity in the context of TiO2 nanoparticle-induced hepatotoxicity.	0.2465
37302631	International journal of biological macromolecules	2023	CircEGFR reduces the sensitivity of pirarubicin and regulates the malignant progression of triple-negative breast cancer via the miR-1299/EGFR axis.	hsa_circ_0080220	CircEGFR	hsa_circ_EGFR	EGFR	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; RNA-seq; Microarray	"circEGFR (hsa_circ_0080220) is up-regulated in TNBC tissues, TNBC cell lines and plasma exosomes, and high expression is associated with poor prognosis. It promotes TNBC proliferation, migration, invasion, EMT, xenograft tumor growth and THP chemoresistance by sponging miR-1299 and increasing EGFR expression. The study suggests circEGFR is a potential diagnostic, prognostic and therapeutic biomarker for TNBC."	0.8705
37303180	Anti-cancer agents in medicinal chemistry	2023	CircFAT1 Promotes the Proliferation and Invasion of Malignant Melanoma through miR375-SLC7A11 Signal Axis.		circFAT1	hsa_circ_FAT1		melanoma	MONDO:0005105	melanoma	up-regulated	RT-qPCR	"circFAT1 is up-regulated in malignant melanoma tissues and promotes melanoma cell proliferation, migration, invasion and clone formation. Mechanistically, it functions as a sponge for miR-375, thereby increasing SLC7A11 expression, and may represent a therapeutic target for malignant melanoma."	0.7551
37306552	Acta biochimica Polonica	2023	Hsa_circ_0023826 protects against glaucoma by regulating miR-188-3p/MDM4 axis.	hsa_circ_0023826	circ_0023826	hsa_circ_TENM4	TENM4	glaucoma	MONDO:0005041	glaucoma	down-regulated	RT-qPCR	"hsa_circ_0023826 is down-regulated in glaucoma-associated retinal neurodegeneration and functions protectively. Its upregulation alleviates visual impairment, promotes RGC survival and viability, and inhibits RGC apoptosis. Mechanistically, it sponges miR-188-3p to regulate MDM4 expression through the circ_0023826/miR-188-3p/MDM4 axis."	0.73
37307805	Oncology	2023	Peripheral Blood-Derived CircVPS35L as a Potential Diagnostic Biomarker for Non-Small Cell Lung Cancer.	hsa_circ_0003645	circVPS35L / circRNA VPS35L	hsa_circ_VPS35L	VPS35L	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	down-regulated	RT-qPCR; Microarray	"This study identifies hsa_circ_0003645/circVPS35L as a down-regulated circRNA in NSCLC tissues, cell lines, and peripheral blood. circVPS35L is a stable circular RNA derived from VPS35L exons 23-26 and shows diagnostic utility for distinguishing NSCLC from healthy controls and benign lung disease, outperforming conventional tumor markers in ROC analyses."	0.6841
37307895	Gene	2023	Effect of circ_0000009 on lung adenocarcinoma progression by regulating PDZD2 in a ceRNA- and RBP- dependent manner.	hsa_circ_0000009	circ_0000009	hsa_circ_SKI	SKI	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	down-regulated	RT-qPCR; Microarray	"hsa_circ_0000009 (circ_0000009) is downregulated in LUAD tissues and cell lines and functions as a tumor suppressor. Its overexpression inhibits LUAD cell proliferation and xenograft tumor growth while promoting apoptosis, through upregulating PDZD2 via miR-154-3p sponging and IGF2BP2-mediated PDZD2 mRNA stabilization."	0.8275
37314551	Biochemical genetics	2024	Circ_0091579 Knockdown Inhibited HCC Proliferation and Glutamine Metabolism Through miR-1270/YAP1 Axis.	hsa_circ_0091579	circ_0091579	hsa_circ_GPC3	GPC3	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"hsa_circ_0091579/circ_0091579 is up-regulated in HCC tissues and cells. It promotes HCC cell proliferation, angiogenesis, invasion, migration, in vivo tumor growth, and glutamine metabolism while suppressing apoptosis. Mechanistically, circ_0091579 sponges miR-1270 to regulate YAP1 expression, suggesting a potential therapeutic target for HCC."	0.8299
37318741	Molecular biotechnology	2024	Hsa_circ_0001741 Suppresses Ovarian Cancer Cell Proliferations Through Adsorption of miR-188-5p and Promotion of FOXN2 Expression.	hsa_circ_0001741	circ-TNPO3	hsa_circ_TNPO3	TNPO3	ovarian cancer / OC	MONDO:0008170	ovarian cancer	down-regulated	RT-qPCR; ISH	"hsa_circ_0001741 is down-regulated in ovarian cancer tissues and cell lines. Its overexpression suppresses ovarian cancer cell proliferation and xenograft tumor growth by sponging miR-188-5p and increasing FOXN2 expression, suggesting potential value as an OC diagnostic biomarker and therapeutic target."	0.7325
37319356	Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research	2023	Circular RNA circTRAPPC6B Enhances IL-6 and IL-1beta Expression and Repolarizes Mycobacteria Induced Macrophages from M2- to M1-Like Phenotype by Targeting miR-892c-3p.		circTRAPPC6B	hsa_circ_TRAPPC6B	TRAPPC6B	tuberculosis / TB	MONDO:0018076	tuberculosis	down-regulated	RT-qPCR	"circTRAPPC6B is a human circRNA downregulated in TB patients and mycobacteria-infected macrophages. In this study, circTRAPPC6B overexpression promoted M1-like macrophage polarization, increased IL-6 and IL-1b, reduced M2-like markers, and inhibited intracellular mycobacterial growth by targeting miR-892c-3p. These findings suggest an immunoregulatory and potential therapeutic role for circTRAPPC6B in tuberculosis."	0.6102
37326964	Toxicological sciences : an official journal of the Society of Toxicology	2023	"CircRNA hsa_circ_0000043 acts as a miR-4492 sponge to promote lung cancer progression via BDNF and STAT3 expression regulation in anti-benzo[a]pyrene-trans-7,8-dihydrodiol-9,10-epoxide-transformed 16HBE cells."	hsa_circ_0000043		hsa_circ_PUM1	PUM1	lung cancer	MONDO:0008903	lung cancer	up-regulated	RT-qPCR; Microarray	"hsa_circ_0000043 is up-regulated in BPDE-transformed 16HBE-T cells, lung cancer cell lines, and lung cancer tissues. It promotes lung cancer progression by sponging miR-4492 and regulating BDNF and STAT3 expression, thereby enhancing proliferation, malignant transformation, migration, invasion, and xenograft tumor growth. Clinically, high hsa_circ_0000043 expression is associated with advanced TNM stage, metastasis, smoking exposure, and poor overall survival."	0.8175
37331414	Cellular signalling	2023	CircSNX25 mediated by SP1 promotes the carcinogenesis and development of triple-negative breast cancer.	hsa_circ_0004874	circSNX25	hsa_circ_SNX25	SNX25	triple-negative breast cancer / TNBC	MONDO:0005494	triple-negative breast carcinoma	up-regulated	RT-qPCR; RNA-seq	"circSNX25 is an up-regulated circular RNA in TNBC tissues and cells. It promotes TNBC proliferation, cell cycle progression and xenograft tumor growth while suppressing apoptosis. Mechanistically, SP1 enhances circSNX25 biogenesis through the SNX25 promoter, and circSNX25 physically interacts with COPB1, supporting its potential value as a TNBC biomarker and therapeutic target."	0.8574
37334706	Journal of biomolecular structure & dynamics	2024	Hsa_circRNA_0000284 acts as a ceRNA to participate in coronary heart disease progression by sponging miRNA-338-3p via regulating the expression of ETS1.	hsa_circ_0000284	circHIPK3 / circ_0000284	hsa_circ_HIPK3	HIPK3	coronary artery disease / CAD	MONDO:0005010	coronary artery disorder	down-regulated	RT-qPCR	"In CHD, hsa_circRNA_0000284 is downregulated in peripheral blood leukocytes. Functionally, hsa_circRNA_0000284 supports endothelial cell proliferation and cell cycle progression while suppressing senescence and apoptosis. Mechanistically, it acts as a ceRNA for hsa-miRNA-338-3p to regulate ETS1 expression, suggesting a role for the hsa_circRNA_0000284/hsa-miRNA-338-3p/ETS1 axis in CHD pathogenesis."	0.7404
37336718	"Nutrition, metabolism, and cardiovascular diseases : NMCD"	2023	Atherosclerosis-associated endothelial dysfunction is promoted by miR-199a-5p/SIRT1 axis regulated by circHIF1¨».	hsa_circ_0032139	circHIF1¨»	hsa_circ_HIF1¨»	HIF1¨»	atherosclerosis / AS	MONDO:0005311	atherosclerosis	down-regulated	RT-qPCR	"circHIF1¨» is a human HIF1¨»-derived circRNA that is downregulated in ox-LDL-treated HAECs. It localizes mainly in the cytoplasm and acts as a sponge for miR-199a-5p, increasing SIRT1 and modulating SIRT1/FOXO3 signaling to protect against ox-LDL-induced endothelial dysfunction by promoting proliferation, migration, and tube formation."	0.6867
37336827	Irish journal of medical science	2024	The quantification of circular RNA 0007841 during induction therapy helps estimate the response and survival benefits to bortezomib-based regimen in multiple myeloma.	hsa_circ_0007841	Circular RNA_0007841			multiple myeloma / MM	MONDO:0009693	plasma cell myeloma	up-regulated	RT-qPCR	"Circ_0007841 is up-regulated in bone marrow plasma cells from multiple myeloma patients compared with healthy controls and decreases after bortezomib-based induction therapy. Higher circ_0007841 expression after therapy is associated with poorer treatment response and independently predicts shorter PFS and OS, supporting its role as a clinical biomarker for response and prognosis."	0.4992
37340152	Inflammation	2023	"Circular RNA CircDHRS3 Aggravates IL-1beta-induced ECM Degradation, Apoptosis, and Inflammatory Response via Mediating MECP2 Expression."	hsa_circ_0010024	circDHRS3	hsa_circ_DHRS3	DHRS3	osteoarthritis / OA	MONDO:0005178	osteoarthritis	up-regulated	RT-qPCR	"In this study, hsa_circ_0010024/circDHRS3 was up-regulated in osteoarthritis cartilage samples and IL-1beta-treated chondrocytes. CircDHRS3 promoted chondrocyte ECM degradation, apoptosis, and inflammatory response and inhibited proliferation by sponging miR-193a-3p to increase MECP2 expression."	0.6536
37341906	International urology and nephrology	2024	CircLARP1B promotes pyroptosis of high glucose-induced renal mesangial cells by regulating the miR-578/TLR4 axis.		circ-LARP1B / circRNA La ribonucleoprotein 1B	hsa_circ_LARP1B	LARP1B	Diabetic nephropathy / DN	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"CircLARP1B is up-regulated in the blood of DN patients and in high glucose-treated human renal mesangial cells. It promotes pyroptosis and inflammatory factor release while inhibiting proliferation and cell cycle progression through the miR-578/TLR4 axis, suggesting therapeutic relevance in DN."	0.742
37343537	International archives of allergy and immunology	2023	CircARF3 Mitigates Allergic Rhinitis through Targeting microRNA-205-5p/Sirtuin 5 Axis.		circRNA ADP-ribosylation factor 3 / circARF3	mmu_circ_ARF3	ARF3	allergic rhinitis / AR	MONDO:0011786	allergic rhinitis	down-regulated	RT-qPCR	"CircARF3 is down-regulated in HDM-induced allergic rhinitis mice and IL-4/IL-13-treated mouse nasal epithelial cells. Its overexpression mitigates epithelial apoptosis, inflammatory cytokine responses, histological injury, and HMGB1/TLR4 signaling activation through the miR-205-5p/SIRT5 axis."	0.782
37344692	Biochemical genetics	2024	Circular RNA 0016142 Knockdown Induces Ferroptosis in Hepatocellular Carcinoma Cells via Modulation of the MicroRNA-188-3p/Glutathione Peroxidase 4 Axis.	hsa_circ_0016142	Circular RNA 0016142 / circ_0016142			Hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0016142 is upregulated in HCC tissues and cells. The study shows that circ_0016142 promotes HCC cell proliferation and tumor growth by sponging miR-188-3p and regulating GPX4, thereby suppressing ferroptosis; knockdown of circ_0016142 induces ferroptosis and reduces malignant phenotypes."	0.7936
37347924	DNA and cell biology	2023	Loss of circIGF1R Suppresses Cardiomyocytes Proliferation by Sponging miR-362-5p.	mmu_circ_0001582	circIGF1R	mmu_circ_IGF1R	IGF1R	heart failure / HF	MONDO:0005252	heart failure	dysregulated	RT-qPCR; ISH; RNA-seq	This study shows that circIGF1R is downregulated in adult heart tissues and cardiomyocytes but increased after neonatal heart injury. Functional experiments indicate that circIGF1R promotes cardiomyocyte proliferation by acting as a sponge for miR-362-5p and relieving repression of Phf3. The circIGF1R/miR-362-5p/Phf3 axis is proposed as a regulator of heart regeneration.	0.8058
37352916	Life sciences	2023	NSD2 promotes pressure overload-induced cardiac hypertrophy via activating circCmiss1/TfR1/ferroptosis signaling.		mm9_circ_005252 / circCmss1	mmu_circ_Cmss1	Cmss1	cardiac hypertrophy	MONDO:0005045	hypertrophic cardiomyopathy	up-regulated	RT-qPCR; Microarray	"circCmss1 is a mouse Cmss1-derived circRNA up-regulated in TAC-induced pressure overload cardiac hypertrophy and Ang II-treated cardiomyocytes. Its knockdown attenuates cardiomyocyte hypertrophy, myocardial fibrosis, and impaired cardiac function, while NSD2/H3K36me2-driven Cmss1 activation elevates circCmss1. Mechanistically, circCmss1 binds EIF4A3 and up-regulates TfR1, activating ferroptosis and promoting ventricular remodeling."	0.7949
37354568	Ecotoxicology and environmental safety	2023	N6-methyladenosine methylation mediates non-coding RNAs modification in microplastic-induced cardiac injury.		circ-Arfgef2	mmu_circ_Arfgef2	Arfgef2	microplastic-induced cardiac injury	MONDO:0004994	cardiomyopathy	up-regulated	RT-qPCR; RNA-seq	"circ-Arfgef2 is a mouse myocardial circRNA whose expression and m6A methylation were increased after chronic microplastic exposure. The study identifies it as a potential mediator of MP-induced myocardial damage, based mainly on integrated RNA-seq and MeRIP-seq analysis with MeRIP-qPCR assessment of m6A level."	0.329
37356630	Biochemical pharmacology	2023	Hsa_circ_0007031 promotes the proliferation and migration of osteosarcoma cells by sponging miR-196a-5p to regulate the HOXB6.	hsa_circ_0007031		hsa_circ_TUBGCP3		osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"In this study, hsa_circ_0007031 is up-regulated in osteosarcoma tissues and cell lines and functions as an oncogenic circRNA. It promotes proliferation, migration, invasion, EMT, tumor growth, metastasis, and stem-like properties by sponging miR-196a-5p to increase HOXB6 expression. The hsa_circ_0007031/miR-196a-5p/HOXB6 axis further modulates chemokines in the cytokine-cytokine receptor interaction pathway and is proposed as a potential therapeutic or diagnostic target in OS."	0.8256
37357410	Environmental and molecular mutagenesis	2023	Circ_0000033 up-regulates NUAK2 by sequestering miR-378a-3p to promote breast tumorigenesis.	hsa_circ_0000033	circ_0000033	hsa_circ_CEP85	CEP85	breast cancer / BC	MONDO:0007254	breast cancer	up-regulated	RT-qPCR	"circ_0000033 is up-regulated in breast cancer tissues and cells. It promotes breast cancer proliferation, migration, invasion, angiogenesis, metastasis and xenograft tumor growth while inhibiting apoptosis and cell cycle arrest. Mechanistically, circ_0000033 sponges miR-378a-3p to release and up-regulate NUAK2, forming a circ_0000033/miR-378a-3p/NUAK2 ceRNA network and suggesting therapeutic potential in BC."	0.8175
37357602	Zhonghua fu chan ke za zhi	2023	[Circular RNA expression profiles and circRNA-miRNA-mRNA crosstalk in pre-eclamptic placenta].		circRNA_00673			preeclampsia / PE	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR; RNA-seq	"circRNA_00673 was significantly up-regulated in PE placental tissue and was included in the circRNA-miRNA-mRNA network. The study predicted that circRNA_00673 may competitively bind hsa-miR-585-5p and hsa-miR-9902 to regulate TREM-1, but its expression was not significantly associated with PE risk or clinical characteristics."	0.4032
37357602	Zhonghua fu chan ke za zhi	2023	[Circular RNA expression profiles and circRNA-miRNA-mRNA crosstalk in pre-eclamptic placenta].		circRNA_07796			preeclampsia / PE	MONDO:0005081	preeclampsia	up-regulated	RT-qPCR; RNA-seq	"circRNA_07796 was significantly up-regulated in PE placental tissue and was included in the circRNA-miRNA-mRNA network. It was predicted to competitively bind hsa-miR-133a-3p and regulate SerpinA5 and SLC4A1, and it was correlated with systolic blood pressure but not independently associated with PE risk after adjustment."	0.4032
37357602	Zhonghua fu chan ke za zhi	2023	[Circular RNA expression profiles and circRNA-miRNA-mRNA crosstalk in pre-eclamptic placenta].		circRNA_05393			preeclampsia / PE	MONDO:0005081	preeclampsia	down-regulated	RT-qPCR; RNA-seq	"circRNA_05393 was significantly down-regulated in PE placental tissue and its lower expression was associated with PE risk and higher blood pressure measures. Functionally, circRNA_05393 promoted trophoblast migration and invasion in HTR-8/SVneo cells, and its inhibition may contribute to PE progression by reducing trophoblast migratory and invasive capacity."	0.6103
37358551	"Hematology (Amsterdam, Netherlands)"	2023	Circ_0104700 contributes to acute myeloid leukemia progression by enhancing MCM2 expression through targeting miR-665.	hsa_circ_0104700	Circ_0104700	hsa_circ_HOMER2	HOMER2	acute myeloid leukemia / AML	MONDO:0018874	acute myeloid leukemia	up-regulated	RT-qPCR; Microarray	"circ_0104700 is up-regulated in AML patient samples and AML cell lines. It promotes AML malignant phenotypes by sponging miR-665 to increase MCM2 expression and activate JAK/STAT signaling, thereby enhancing proliferation and cell cycle progression while suppressing apoptosis."	0.697
37358666	Journal of cancer research and clinical oncology	2023	Screening and validating circular RNAs that estimate disease risk and treatment response of pediatric acute myeloid leukemia: a microarray-based analyses and RT-qPCR validation.	hsa_circ_0032891	circ_0032891			pediatric acute myeloid leukemia / pediatric AML	MONDO:0004996	childhood acute myeloid leukemia	up-regulated	RT-qPCR; Microarray	"circ_0032891 was validated as up-regulated in pediatric AML bone marrow samples. It was associated with pediatric AML risk, CR achievement, and shorter EFS when highly expressed."	0.5734
37358666	Journal of cancer research and clinical oncology	2023	Screening and validating circular RNAs that estimate disease risk and treatment response of pediatric acute myeloid leukemia: a microarray-based analyses and RT-qPCR validation.	hsa_circ_0076995	circ_0076995	hsa_circ_EEF1A1	EEF1A1	pediatric acute myeloid leukemia / pediatric AML	MONDO:0004996	childhood acute myeloid leukemia	up-regulated	RT-qPCR; Microarray	"circ_0076995 was validated as up-regulated in pediatric AML. Its high expression was linked to poorer survival, including shorter EFS and unfavorable OS, and it was associated with pediatric AML risk and CR achievement."	0.5734
37358666	Journal of cancer research and clinical oncology	2023	Screening and validating circular RNAs that estimate disease risk and treatment response of pediatric acute myeloid leukemia: a microarray-based analyses and RT-qPCR validation.	hsa_circ_0014352	circ_0014352			pediatric acute myeloid leukemia / pediatric AML	MONDO:0004996	childhood acute myeloid leukemia	up-regulated	RT-qPCR; Microarray	"circ_0014352 was validated as up-regulated in pediatric AML and could distinguish AML patients from controls. It was also associated with CR achievement, but no survival association was reported."	0.5047
37358666	Journal of cancer research and clinical oncology	2023	Screening and validating circular RNAs that estimate disease risk and treatment response of pediatric acute myeloid leukemia: a microarray-based analyses and RT-qPCR validation.	hsa_circ_0047663	circ_0047663			pediatric acute myeloid leukemia / pediatric AML	MONDO:0004996	childhood acute myeloid leukemia	up-regulated	RT-qPCR; Microarray	"circ_0047663 was validated as up-regulated in pediatric AML. It was associated with pediatric AML risk and treatment response, but not with EFS or OS."	0.5047
37358666	Journal of cancer research and clinical oncology	2023	Screening and validating circular RNAs that estimate disease risk and treatment response of pediatric acute myeloid leukemia: a microarray-based analyses and RT-qPCR validation.	hsa_circ_0007444	circ_0007444			pediatric acute myeloid leukemia / pediatric AML	MONDO:0004996	childhood acute myeloid leukemia	down-regulated	RT-qPCR; Microarray	"circ_0007444 was validated as down-regulated in pediatric AML. It was associated with pediatric AML risk and CR achievement, while the discussion mentions possible microRNA-570-3p/PTEN and RHOBTB3-related mechanisms."	0.5047
37358666	Journal of cancer research and clinical oncology	2023	Screening and validating circular RNAs that estimate disease risk and treatment response of pediatric acute myeloid leukemia: a microarray-based analyses and RT-qPCR validation.	hsa_circ_0001684	circ_0001684			pediatric acute myeloid leukemia / pediatric AML	MONDO:0004996	childhood acute myeloid leukemia	down-regulated	RT-qPCR; Microarray	"circ_0001684 was validated as down-regulated in pediatric AML. It was associated with disease risk and CR achievement, and high expression correlated with longer OS."	0.5734
37358666	Journal of cancer research and clinical oncology	2023	Screening and validating circular RNAs that estimate disease risk and treatment response of pediatric acute myeloid leukemia: a microarray-based analyses and RT-qPCR validation.	hsa_circ_0000544	circ_0000544			pediatric acute myeloid leukemia / pediatric AML	MONDO:0004996	childhood acute myeloid leukemia	down-regulated	RT-qPCR; Microarray	"circ_0000544 was validated as down-regulated in pediatric AML. It was associated with disease risk, CR achievement, and prolonged EFS when highly expressed."	0.5734
37358666	Journal of cancer research and clinical oncology	2023	Screening and validating circular RNAs that estimate disease risk and treatment response of pediatric acute myeloid leukemia: a microarray-based analyses and RT-qPCR validation.	hsa_circ_0005354	circ_0005354			pediatric acute myeloid leukemia / pediatric AML	MONDO:0004996	childhood acute myeloid leukemia	down-regulated	RT-qPCR; Microarray	"circ_0005354 was validated as down-regulated in pediatric AML and could distinguish pediatric AML patients from controls. It was not associated with CR achievement, EFS, or OS."	0.5047
37368192	Human cell	2023	Circular RNA circ_KIAA1429 accelerates hepatocellular carcinoma progression via the miR-133a-3p/high mobility group AT-hook 2 (HMGA2) axis in an m6A-dependent manner.		circ_KIAA1429	hsa_circ_KIAA1429	KIAA1429	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_KIAA1429 is up-regulated in HCC tissues and cells and functions as an oncogenic circRNA. METTL3-mediated m6A modification increases circ_KIAA1429 expression, and circ_KIAA1429 promotes HCC proliferation, migration, cell-cycle-related gene expression and xenograft tumor growth by sponging miR-133a-3p to upregulate HMGA2. Its expression is associated with more advanced clinicopathologic features, suggesting potential diagnostic and therapeutic biomarker value."	0.8005
37369798	Journal of cancer research and clinical oncology	2023	Circ_103128 is associated with the tumorigenesis of medulloblastoma.	hsa_circ_0061694	Circ_103128	hsa_circ_DYRK1A	DYRK1A	Medulloblastoma / MB	MONDO:0007959	medulloblastoma	up-regulated	RT-qPCR; Microarray	"circRNA_103128 is up-regulated in medulloblastoma and functions as a tumor-promoting circRNA. Its knockdown suppresses MB cell proliferation, migration, invasion and xenograft tumor growth while increasing apoptosis. Mechanistically, it acts through a miR-129-5p sponge effect to regulate SOX4 expression, suggesting potential therapeutic relevance."	0.678
37369954	Molecular biotechnology	2024	CircUTRN24/miR-483-3p/IGF-1 Regulates Autophagy Mediated Liver Fibrosis in Biliary Atresia.	hsa_circ_0009096	circUTRN24 / circ_0009096	hsa_circ_UTRN24	UTRN	Biliary atresia / BA	MONDO:0008867	biliary atresia	up-regulated	RT-qPCR	"circUTRN24 is up-regulated in biliary atresia and in TGF-beta-induced LX-2 fibrotic cells. It promotes hepatic stellate cell activation and fibrosis by enhancing autophagy through the circUTRN24/miR-483-3p/IGF-1 axis, involving autophagy-related mTOR signaling. Knockdown of circUTRN24 reduces IGF-1 expression, autophagy-related proteins, and HSC activation markers, suggesting potential therapeutic and biomarker relevance for BA hepatic fibrosis."	0.5079
37376914	Journal of biochemical and molecular toxicology	2023	Matrine suppresses liver cancer progression and the Warburg effect by regulating the circROBO1/miR-130a-5p/ROBO1 axis.	hsa_circ_0066568	circROBO1	hsa_circ_ROBO1	ROBO1	liver cancer	MONDO:0002691	liver cancer	up-regulated	RT-qPCR; Microarray	"circROBO1 is upregulated in liver cancer tissues and functions as an oncogenic circRNA. It promotes liver cancer cell viability, proliferation, antiapoptosis capacity, and Warburg effect by sponging miR-130a-5p to increase ROBO1 expression. Matrine suppresses liver cancer progression partly by downregulating circROBO1 and inhibiting the circROBO1/miR-130a-5p/ROBO1 axis."	0.7855
37376914	Journal of biochemical and molecular toxicology	2023	Matrine suppresses liver cancer progression and the Warburg effect by regulating the circROBO1/miR-130a-5p/ROBO1 axis.	hsa_circ_0001583	circHIST1H1C	hsa_circ_HIST1H1C	HIST1H1C	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	Microarray	"hsa_circ_0001583 (circHIST1H1C) was identified by GSE155949 microarray analysis as upregulated in hepatocellular carcinoma tumor tissues compared with adjacent nontumor tissues. The study did not report functional assays, molecular mechanism, subcellular localization, or clinical prognosis for this circRNA."	0.1768
37376914	Journal of biochemical and molecular toxicology	2023	Matrine suppresses liver cancer progression and the Warburg effect by regulating the circROBO1/miR-130a-5p/ROBO1 axis.	hsa_circ_0001387	circWHSC1	hsa_circ_WHSC1	WHSC1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	Microarray	"hsa_circ_0001387 (circWHSC1) was identified by GSE155949 microarray analysis as upregulated in hepatocellular carcinoma tumor tissues compared with adjacent nontumor tissues. The study did not report functional assays, molecular mechanism, subcellular localization, or clinical prognosis for this circRNA."	0.1768
37377048	Head & neck	2023	The role and mechanism of circ-BNC2 on the malignant progression of oral squamous cell carcinoma.	hsa_circ_0086414	circ-BNC2 / Circ_0086414	hsa_circ_BNC2	BNC2	oral squamous cell carcinoma / OSCC	MONDO:0004958	oral cavity squamous cell carcinoma	down-regulated	RT-qPCR	"Circ-BNC2 is downregulated in OSCC tissues and cells and acts as a tumor-suppressive circRNA. Its overexpression inhibits OSCC proliferation, migration, invasion and xenograft tumor growth while promoting apoptosis, cell cycle arrest and oxidative stress. Mechanistically, circ-BNC2 binds miR-142-3p to upregulate GNAS expression through the circ-BNC2/miR-142-3p/GNAS axis."	0.8567
37378808	"Hormones (Athens, Greece)"	2023	Circ_0011373 promotes papillary thyroid carcinoma progression by regulating miR-1271/LRP6 axis.	hsa_circ_0011373	circ_0011373 / circEIF3I	hsa_circ_EIF3I	EIF3I	papillary thyroid carcinoma / PTC	MONDO:0005075	thyroid gland papillary carcinoma	up-regulated	RT-qPCR	"circ_0011373 is up-regulated in papillary thyroid carcinoma tissues and cell lines. It promotes PTC progression by sponging miR-1271 and positively regulating LRP6, thereby enhancing cell cycle progression, migration, invasion and in vivo tumor growth while inhibiting apoptosis. Its high expression is associated with TNM stage and lymphatic metastasis, suggesting potential clinical and therapeutic relevance."	0.7045
37389129	Cytotechnology	2023	M2 macrophage-derived extracellular vesicles augment immune evasion and development of colorectal cancer via a circRNA_CCDC66/microRNA-342-3p/metadherin axis.		circRNA_CCDC66	hsa_circ_CCDC66	CCDC66	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"This study shows that M2 macrophage-derived extracellular vesicles are enriched in circ_CCDC66 and can deliver it into CRC cells. circ_CCDC66 promotes CRC proliferation, migration, invasion, xenograft tumor growth, and immune evasion by sponging miR-342-3p and restoring MTDH expression, which is linked to reduced CD8+ T-cell cytotoxicity and increased PDL1."	0.657
37389702	Molecular biology reports	2023	hsa_circ_0000417 downregulation suppresses androgen receptor expression and apoptotic signals in human foreskin fibroblasts via sponging miR-6756-5p.	hsa_circ_0000417				hypospadias	MONDO:0005345	hypospadias	down-regulated	RNA-seq	"hsa_circ_0000417 is downregulated in hypospadias preputial tissue and functions in HFF-1 cells as a cytoplasmic ceRNA that sponges miR-6756-5p. By relieving miR-6756-5p-mediated repression of AR, it suppresses PI3K/AKT activation, promotes pro-apoptotic signaling, and inhibits fibroblast proliferation, suggesting a mechanism for impaired penile mesenchymal apoptosis in hypospadias."	0.6157
37391048	Cellular signalling	2023	CircNCOR1 regulates breast cancer radiotherapy efficacy by regulating CDK2 via hsa-miR-638 binding.	hsa_circ_0042174	circNCOR1	hsa_circ_NCOR1	NCOR1	breast cancer / BC	MONDO:0007254	breast cancer	down-regulated	RT-qPCR; RNA-seq	"circNCOR1 is a human NCOR1-derived circRNA that is downregulated after irradiation in TNBC cell lines. Its overexpression promotes proliferation and colony formation, inhibits radiation-induced apoptosis, and decreases radiosensitivity by sponging hsa-miR-638 to increase CDK2 expression. In xenograft tumors, circNCOR1 overexpression partially reverses radiation-induced tumor structural loosening and apoptosis."	0.8279
37392008	The journal of gene medicine	2023	Hsa_circ_0003596 enhances the development of cell renal clear cell carcinoma through the miR-502-5p/IGF1/PI3K/AKT axis.	hsa_circ_0003596	circ_0003596	hsa_circ_COL5A1	COL5A1	clear cell renal cell carcinoma / ccRCC	MONDO:0005005	clear cell renal carcinoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_0003596 is up-regulated in ccRCC tissues and cell lines and is associated with distant metastasis. Functionally, it acts as an oncogenic circRNA that promotes proliferation, tumor growth, migration, infiltration/invasion and lung metastasis. Mechanistically, cytoplasmic hsa_circ_0003596 sponges miR-502-5p to increase IGF1R expression and activate the downstream PI3K/AKT signaling cascade, suggesting potential biomarker and therapeutic-target value in ccRCC."	0.8748
37392146	Environmental and molecular mutagenesis	2023	Downregulation of circular RNA hsa_circ_0087856 sensitizes bladder cancer cells to cisplatin through targeting miR-1184/CITED2 signaling.	hsa_circ_0087856				bladder cancer / BCa	MONDO:0004986	urinary bladder carcinoma	up-regulated	RT-qPCR	"hsa_circ_0087856 is up-regulated in bladder cancer tissues and cell lines. It promotes bladder cancer cell proliferation, migration, invasion, tumor growth and cisplatin resistance while inhibiting apoptosis. Mechanistically, hsa_circ_0087856 sponges miR-1184 to regulate CITED2 expression, and its downregulation enhances cisplatin sensitivity."	0.6542
37392398	Journal of biochemical and molecular toxicology	2023	CircDUS2L (circ_0039908) promotes lung adenocarcinoma progression by upregulating PGAM1 by acting as a miR-590-5p molecular sponge.	hsa_circ_0039908	circDUS2L / circ_0039908	hsa_circ_DUS2L	DUS2L	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR; Microarray	"circDUS2L is upregulated in LUAD tissues and cells and promotes malignant phenotypes, glycolysis, and xenograft tumor growth. Mechanistically, it acts as a cytoplasmic miR-590-5p sponge to increase PGAM1 expression and activate TGF-beta signaling, suggesting potential therapeutic relevance in LUAD."	0.8635
37393417	Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico	2023	Hsa_circ_0102899 promotes epithelial-mesenchymal transition in non-small cell lung cancer.	hsa_circ_0102899	circ_0102899			non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"hsa_circ_0102899 is up-regulated in NSCLC tissues and cell lines and is associated with adverse clinicopathological features and poor prognosis. Functionally, it promotes NSCLC malignant progression, including proliferation, migration, invasion, EMT, metastasis, and xenograft tumor growth, partly by acting through the miR-885-5p/EIF4G2 regulatory axis."	0.8326
37393518	Journal of biochemical and molecular toxicology	2023	Circ_0005615 promotes cervical cancer cell growth and metastasis by modulating the miR-138-5p/KDM2A axis.	hsa_circ_0005615	circ_0005615 / circNFATC3	hsa_circ_NFATC3	NFATC3	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR	"circ_0005615 is up-regulated in cervical cancer tissues and cells and functions as an oncogenic circRNA. It promotes CC cell growth, migration, invasion, metastasis and xenograft tumor growth while suppressing apoptosis. Mechanistically, circ_0005615 sponges miR-138-5p to increase KDM2A expression, forming a circ_0005615/miR-138-5p/KDM2A regulatory axis that may represent a therapeutic target."	0.844
37397922	Toxicology research	2023	Hsa_circ_0084003 modulates glycolysis and epithelial-mesenchymal transition in pancreatic ductal adenocarcinoma through targeting hsa-miR-143-3p/DNMT3A axis.	hsa_circ_0084003		hsa_circ_FGFR1	FGFR1	Pancreatic ductal adenocarcinoma / PDAC	MONDO:0005184	pancreatic ductal adenocarcinoma	up-regulated	RT-qPCR	"This study identifies hsa_circ_0084003 as a pro-oncogenic circRNA in PDAC cell models. It promotes aerobic glycolysis and EMT by sponging hsa-miR-143-3p and regulating DNMT3A, suggesting potential value as a targeted therapeutic biomarker."	0.7716
37402652	Carcinogenesis	2023	RNA sequencing reveals the implication of the circRNA-associated ceRNA network in oesophageal squamous cell carcinoma.	hsa_circ_0002470	circIFI6	hsa_circ_IFI6	IFI6	oesophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0002470/circIFI6 is a human circRNA derived from IFI6 that is up-regulated in ESCC tissues and cell lines. It promotes ESCC proliferation, migration and invasion, likely through a ceRNA mechanism involving miR-497-5p/miR-195-5p and hub genes such as HK2, MYLK, CDKN1A, CDH3 and TGFBI."	0.7606
37402652	Carcinogenesis	2023	RNA sequencing reveals the implication of the circRNA-associated ceRNA network in oesophageal squamous cell carcinoma.	hsa_circ_0086414				oesophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0086414 was identified as one of five dysregulated circRNAs in an ESCC circRNA-associated ceRNA network. Its individual miRNA partners and expression direction were not fully specified in the provided text, but it was included in a predicted circRNA-miRNA-mRNA network involving 197 target genes."	0.4685
37402652	Carcinogenesis	2023	RNA sequencing reveals the implication of the circRNA-associated ceRNA network in oesophageal squamous cell carcinoma.	hsa_circ_0001776				oesophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0001776 was identified as one of five dysregulated circRNAs in an ESCC circRNA-associated ceRNA network. It was supported by circRNA sequencing and qRT-PCR validation of selected circRNAs, but its individual host gene, expression direction and precise miRNA pairing were not specified in the provided text."	0.4685
37402652	Carcinogenesis	2023	RNA sequencing reveals the implication of the circRNA-associated ceRNA network in oesophageal squamous cell carcinoma.	hsa_circ_0081168				oesophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0081168 was identified as one of five dysregulated circRNAs in an ESCC ceRNA network and was described as being central in a subnetwork involving prognostic-related hub genes. The study did not further experimentally characterize its individual mechanism beyond sequencing, qRT-PCR-supported selection and bioinformatic network analysis."	0.4685
37402652	Carcinogenesis	2023	RNA sequencing reveals the implication of the circRNA-associated ceRNA network in oesophageal squamous cell carcinoma.	hsa_circ_0018064				oesophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	dysregulated	RT-qPCR; RNA-seq	"hsa_circ_0018064 was identified as one of five dysregulated circRNAs included in the ESCC circRNA-miRNA-mRNA ceRNA network. The paper supports its disease association through circRNA sequencing, qRT-PCR validation of selected circRNAs and bioinformatic network construction, but does not provide individual mechanistic experiments for this circRNA."	0.4685
37405427	Archives of dermatological research	2023	CircIFFO1 suppresses tumor growth and metastasis of cutaneous squamous cell carcinoma by targeting the miR-424-5p/NFIB axis.	hsa_circ_0000375	CircIFFO1	hsa_circ_IFFO1	IFFO1	Cutaneous squamous cell carcinoma / CSCC	MONDO:0002529	skin squamous cell carcinoma	down-regulated	RT-qPCR	"CircIFFO1 is down-regulated in CSCC tissues and cell lines and functions as a tumor suppressor. Mechanistically, it sponges miR-424-5p to up-regulate NFIB, thereby inhibiting proliferation, migration, invasion, EMT and xenograft tumor growth while promoting apoptosis. The circIFFO1/miR-424-5p/NFIB axis may represent a potential therapeutic target for CSCC."	0.8171
37407394	Burns : journal of the International Society for Burn Injuries	2023	Hsa_circ_0000129 knockdown attenuates proliferation and migration in keloid fibroblasts by targeting miR-485-3p/SGMS2 pathway.	hsa_circ_0000129	circ_0000129	hsa_circ_TMOD4	TMOD4	keloid	MONDO:0005348	keloid	up-regulated	RT-qPCR	"circ_0000129 is up-regulated in keloid tissues and keloid fibroblasts. It promotes keloid fibroblast proliferation and migration through a ceRNA mechanism in which it sponges miR-485-3p and relieves miR-485-3p-mediated suppression of SGMS2. Knockdown of circ_0000129 attenuates these cellular phenotypes, suggesting potential therapeutic relevance for keloid."	0.7795
37408092	Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology	2023	Circular RNA differential expression profiles and bioinformatics analysis of hsa_circRNA_079422 in human endometrial carcinoma.		hsa_circRNA_079422			endometrial cancer / EC	MONDO:0011962	endometrial cancer	down-regulated	RT-qPCR; Microarray	"hsa_circRNA_079422 is significantly downregulated in human endometrial carcinoma tissues and was validated by qRT-PCR. The study predicts that it may act through circRNA-miRNA-target gene networks involving miR-136-5p and other miRNAs, with target genes enriched in Notch signalling, amino acid metabolism, biosynthesis pathways, and other biological processes. The authors propose hsa_circRNA_079422 as a potential EC biomarker for diagnosis, treatment, prognosis-related research, and molecular stratification."	0.5135
37416515	Journal of geriatric cardiology : JGC	2023	Down-regulation of the Smad signaling by circZBTB46 via the Smad2-PDLIM5 axis to inhibit type I collagen expression.	hsa_circ_0002805	circZBTB46	hsa_circ_ZBTB46	ZBTB46	abdominal aortic aneurysm / AAA	MONDO:0005350	abdominal aortic aneurysm	up-regulated	RT-qPCR; ISH; RNA-seq	"circZBTB46 is a human ZBTB46-derived circRNA that is increased in abdominal aortic aneurysm tissues. In VSMCs, it binds PDLIM5 and promotes the PDLIM5-Smad2 interaction, inhibiting TGF-beta/Smad signaling and suppressing COL1A2/type I collagen expression, suggesting a role in vascular ECM remodeling and aneurysm development."	0.8115
37417879	Environmental toxicology	2023	CircWHSC1 serves as a prognostic biomarker and promotes malignant progression of non-small-cell lung cancer via miR-590-5p/SOX5 axis.		circWHSC1	hsa_circ_WHSC1	WHSC1	non-small cell lung cancer / NSCLC	MONDO:0005233	non-small cell lung carcinoma	up-regulated	RT-qPCR	"circWHSC1 is up-regulated in NSCLC tissues and cell lines and its high expression predicts poorer overall survival. Functionally, circWHSC1 promotes NSCLC proliferation, migration, invasion and xenograft tumor growth. Mechanistically, it acts as a ceRNA by sponging miR-590-5p to increase SOX5 expression, forming a circWHSC1/miR-590-5p/SOX5 oncogenic axis."	0.7548
37419489	"Stem cells (Dayton, Ohio)"	2023	hucMSCs Treatment Ameliorated Pulmonary Fibrosis via Downregulating the circFOXP1-HuR-EZH2/STAT1/FOXK1 Autophagic Axis.		circ057 / circFOXP1	hsa_circ_FOXP1	FOXP1	pulmonary fibrosis	MONDO:0002771	pulmonary fibrosis	up-regulated	RT-qPCR	"circFOXP1 is up-regulated in pulmonary fibrosis models and acts as a profibrotic circRNA. hucMSCs treatment downregulates circFOXP1, which reduces HuR stability and nucleocytoplasmic shuttling, decreases EZH2/STAT1/FOXK1, enhances autophagy, and thereby attenuates pulmonary fibrosis."	0.5706
37419489	"Stem cells (Dayton, Ohio)"	2023	hucMSCs Treatment Ameliorated Pulmonary Fibrosis via Downregulating the circFOXP1-HuR-EZH2/STAT1/FOXK1 Autophagic Axis.		circ057 / circFOXP1	mmu_circ_FOXP1	FOXP1	pulmonary fibrosis	MONDO:0002771	pulmonary fibrosis	up-regulated	RT-qPCR	"circFOXP1 is up-regulated in pulmonary fibrosis models and acts as a profibrotic circRNA. hucMSCs treatment downregulates circFOXP1, which reduces HuR stability and nucleocytoplasmic shuttling, decreases EZH2/STAT1/FOXK1, enhances autophagy, and thereby attenuates pulmonary fibrosis."	0.5706
37421213	Journal of viral hepatitis	2023	Depletion of circ_0088046 suppressed cell growth and motility of hepatocellular carcinoma via circ_0088046-miR-1299-RTKN2 ceRNA pathway.	hsa_circ_0088046	circ_0088046	hsa_circ_SUSD1	SUSD1	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR	"circ_0088046 is up-regulated in HCC tissues and cells. It promotes HCC cell proliferation, migration, invasion and in vivo tumour growth while suppressing apoptosis. Mechanistically, circ_0088046 acts as a ceRNA sponge for miR-1299 to regulate RTKN2, making it a potential therapeutic target for HCC."	0.8298
37424115	"Cell cycle (Georgetown, Tex.)"	2023	Circular RNA PGPEP1 induces colorectal cancer malignancy and immune escape.	hsa_circ_0050102	circPGPEP1	hsa_circ_PGPEP1	PGPEP1	colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR; Microarray	"circPGPEP1/hsa_circ_0050102 is up-regulated in colorectal cancer tissues and cell lines and is associated with lymph node metastasis and poor survival prognosis. It promotes CRC malignancy and immune escape by sponging miR-515-5p to mediate NFAT5 expression, thereby enhancing proliferation, migration, invasion, EMT and tumor growth while suppressing apoptosis and anti-tumor T-cell activity."	0.8889
37424831	American journal of cancer research	2023	Circular RNA hsa_circ_001350 contributes to osteosarcoma progression by regulating microRNA-578/CCR4-NOT transcription complex and subunit 7/Wnt signaling.	hsa_circ_0000253	hsa_circ_001350	hsa_circ_BLNK	BLNK	osteosarcoma / OS	MONDO:0009807	osteosarcoma	up-regulated	RT-qPCR; Microarray	"hsa_circ_001350 is up-regulated in osteosarcoma samples and cell lines and acts as an oncogenic circRNA. It promotes OS cell proliferation, migration, and invasion while suppressing apoptosis by sponging miR-578, thereby increasing CNOT7 protein levels and activating Wnt/beta-catenin-related signaling. The study suggests that hsa_circ_001350 and its miR-578/CNOT7/Wnt axis may be therapeutic targets in osteosarcoma."	0.7204
37427890	Molecular and cellular biology	2023	CircTTLL13 Promotes TMZ Resistance in Glioma via Modulating OLR1-Mediated Activation of the Wnt/beta-Catenin Pathway.		circTTLL13 / circ0036784	hsa_circ_TTLL13	TTLL13	glioma	MONDO:0021042	glioma	up-regulated	RT-qPCR; Microarray	"circTTLL13 is up-regulated in TMZ-resistant glioma cells and promotes temozolomide resistance. Mechanistically, it recruits YTHDF1 and METTL3 to enhance OLR1 mRNA stability and m6A methylation of OLR1 pre-mRNA, leading to activation of the OLR1-mediated Wnt/beta-catenin pathway."	0.8152
37431919	Molecular carcinogenesis	2023	Circ_0001589/miR-1248/HMGB1 axis enhances EMT-mediated metastasis and cisplatin resistance in cervical cancer.	hsa_circ_0001589	circ_0001589	hsa_circ_H1d	H1d	cervical cancer / CC	MONDO:0002974	cervical cancer	up-regulated	RT-qPCR; ISH	"circ_0001589 is up-regulated in cervical cancer tissues and cell lines. It promotes EMT-mediated migration, invasion, lung metastasis, and cisplatin/DDP resistance by acting as a ceRNA for miR-1248 and increasing HMGB1 expression. Knockdown of circ_0001589 sensitizes cervical cancer cells to DDP and suppresses malignant phenotypes, supporting its potential as a therapeutic target."	0.8519
37432457	Journal of cancer research and clinical oncology	2023	Colorectal cancer-secreted exosomal circ_001422 plays a role in regulating KDR expression and activating mTOR signaling in endothelial cells by targeting miR-195-5p.	hsa_circ_0004771	circ_0004771			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0004771 was significantly up-regulated in serum from CRC patients. Its higher expression was associated with advanced stage and lymph node metastasis, and ROC analysis suggested diagnostic potential."	0.4187
37432457	Journal of cancer research and clinical oncology	2023	Colorectal cancer-secreted exosomal circ_001422 plays a role in regulating KDR expression and activating mTOR signaling in endothelial cells by targeting miR-195-5p.	hsa_circ_0101802	circ_0101802			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0101802 was significantly up-regulated in serum from CRC patients. Higher expression correlated with advanced stage and lymph node metastasis, and ROC analysis indicated diagnostic value."	0.4187
37432457	Journal of cancer research and clinical oncology	2023	Colorectal cancer-secreted exosomal circ_001422 plays a role in regulating KDR expression and activating mTOR signaling in endothelial cells by targeting miR-195-5p.	hsa_circ_0082333	circ_0082333			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_0082333 was significantly up-regulated in serum from CRC patients. Higher expression was associated with advanced CRC stage and lymph node metastasis, and ROC analysis supported diagnostic value."	0.4187
37432457	Journal of cancer research and clinical oncology	2023	Colorectal cancer-secreted exosomal circ_001422 plays a role in regulating KDR expression and activating mTOR signaling in endothelial cells by targeting miR-195-5p.	hsa_circ_0072309	circ_0072309			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	down-regulated	RT-qPCR	"circ_0072309 was significantly down-regulated in CRC serum and showed diagnostic potential by ROC analysis. Unlike the other candidate circRNAs, it was not significantly associated with TNM stage or lymph node metastasis."	0.4187
37432457	Journal of cancer research and clinical oncology	2023	Colorectal cancer-secreted exosomal circ_001422 plays a role in regulating KDR expression and activating mTOR signaling in endothelial cells by targeting miR-195-5p.		circ_001422			colorectal cancer / CRC	MONDO:0005575	colorectal cancer	up-regulated	RT-qPCR	"circ_001422 is up-regulated in CRC serum, CRC cells, and CRC-derived exosomes and has diagnostic relevance, including association with advanced stage and lymph node metastasis. Mechanistically, exosomal circ_001422 from aggressive CRC cells is transferred to endothelial cells, where it sponges miR-195-5p, increases KDR expression, activates PI3K/AKT/mTOR signaling, and promotes endothelial proliferation, migration, and angiogenesis."	0.7078
37442529	Molecular and cellular probes	2023	CircCPSF6 promotes hepatocellular carcinoma cancer progression by regulating MAP4K4 through sponging miR-145-5p.		circCPSF6	hsa_circ_CPSF6	CPSF6	hepatocellular carcinoma / HCC	MONDO:0007256	hepatocellular carcinoma	up-regulated	RT-qPCR; Microarray	"circCPSF6 is up-regulated in human HCC tissues and cell lines and functions as a pro-tumorigenic circRNA. It promotes HCC proliferation, migration, and xenograft tumor growth by sponging miR-145-5p and thereby upregulating MAP4K4. The circCPSF6-miR-145-5p-MAP4K4 axis is proposed as a potential biomarker and therapeutic target in HCC."	0.8658
37452271	Apoptosis : an international journal on programmed cell death	2023	Mechanism of tumor-derived extracellular vesicles in prostatic cancer progression through the circFMN2/KLF2/RNF128 axis.	hsa_circ_0005100	circRNA formin 2 / Circ_0005100	hsa_circ_FMN2	FMN2	prostate cancer / PCa	MONDO:0008315	prostate cancer	up-regulated	RT-qPCR	"circFMN2 is upregulated in prostatic cancer tissues and cell lines and is shuttled between PC cells by tumor-derived extracellular vesicles. It promotes proliferation, invasion, migration, tumor growth, and lung/liver metastasis by binding HuR, reducing HuR-mediated KLF2 mRNA stability, and repressing the KLF2/RNF128 transcriptional axis. Clinically, higher circFMN2 expression correlates with tumor stage, lymph-node metastasis, and Gleason score."	0.8644
37455293	General thoracic and cardiovascular surgery	2024	CircGFPT1 regulates the growth and apoptosis of esophageal squamous cell carcinoma through miR-142-5p/HAX1 axis.	hsa_circ_0055038	CircGFPT1	hsa_circ_GFPT1	GFPT1	esophageal squamous cell carcinoma / ESCC	MONDO:0005580	esophageal squamous cell carcinoma	up-regulated	RT-qPCR	"CircGFPT1 is up-regulated in ESCC tissues and cell lines and high expression is associated with worse overall survival. Functionally, circGFPT1 promotes proliferation, migration, invasion and xenograft tumor growth while suppressing apoptosis. Mechanistically, it acts as a cytoplasmic ceRNA that sponges miR-142-5p to increase HAX1 expression."	0.8354
37459866	Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme	2023	Prognostic Value of hsa_circ_0007615 in Epithelial Ovarian Cancer and its Regulatory Effect on Tumor Progression.	hsa_circ_0007615		hsa_circ_PTPN14	PTPN14	epithelial ovarian cancer / EOC	MONDO:0005140	ovarian carcinoma	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0007615 is up-regulated in epithelial ovarian cancer tissues and cell lines and serves as an independent poor-prognosis and recurrence biomarker. Functionally, it promotes EOC cell proliferation, migration and invasion and appears to inhibit ferroptosis-related cell death. Mechanistically, it acts as a ceRNA by sponging miR-874-3p and regulating the downstream target TUBB3."	0.8143
37463596	"Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association"	2023	"Circular RNA circADAM9 Promotes Inflammation, Oxidative Stress, and Fibrosis of Human Mesangial Cells via the Keap1-Nrf2 Pathway in Diabetic Nephropathy."	hsa_circ_0084043	circADAM9	hsa_circ_ADAM9	ADAM9	diabetic nephropathy / DN	MONDO:0005016	diabetic kidney disease	up-regulated	RT-qPCR	"circADAM9 is upregulated in serum samples from diabetic nephropathy patients and in high glucose-treated human mesangial cells. It promotes mesangial cell injury, including proliferation, migration, inflammation, fibrosis, and oxidative stress, by sponging miR-545-3p to activate USP15 and inhibit the Keap1/Nrf2 pathway. The study suggests circADAM9 may be a potential therapeutic target for diabetic nephropathy."	0.7032
37466171	Environmental toxicology	2023	Circular RNA nuclear receptor interacting protein 1 promoted biliary tract cancer epithelial-mesenchymal transition and stemness by regulating the miR-515-5p/AKT2 axis and PI3K/AKT/mTOR signaling pathway.	hsa_circ_0004771		hsa_circ_NRIP1	NRIP1	biliary tract cancer / BTC	MONDO:0003060	biliary tract cancer	up-regulated	RT-qPCR	"circ_NRIP1 is overexpressed in BTC tissues and cells and is associated with advanced disease features and poor overall survival. Functionally, circ_NRIP1 promotes proliferation, invasion, migration, stemness, EMT, xenograft growth, and metastasis. Mechanistically, it sponges miR-515-5p to upregulate AKT2 and activate the PI3K/AKT/mTOR pathway."	0.8658
37466964	Asian Pacific journal of allergy and immunology	2023	"Gene expression profiles of mRNA, lncRNA, miRNA, and circRNA and their clinical implications in chronic rhinosinusitis with nasal polyps."	hsa_circ_0021727		hsa_circ_CD44	CD44	chronic rhinosinusitis	MONDO:0006031	chronic rhinosinusitis	up-regulated	RT-qPCR; RNA-seq	circ_0021727 is up-regulated in CRSwNP and was validated by RT-qPCR and Sanger sequencing. It is proposed as a potential circRNA-miR145-5p-PCDH10 ceRNA marker associated with eosinophilic and inflammatory clinical indicators and may have diagnostic/prognostic value.	0.5963
37466964	Asian Pacific journal of allergy and immunology	2023	"Gene expression profiles of mRNA, lncRNA, miRNA, and circRNA and their clinical implications in chronic rhinosinusitis with nasal polyps."	hsa_circ_0002617	circ_0002617			chronic rhinosinusitis	MONDO:0006031	chronic rhinosinusitis	dysregulated	RT-qPCR; RNA-seq	circ_0002617 was one of the differentially expressed circRNAs validated in CRSwNP. It was clinically relevant because its expression negatively correlated with eosinophilic indicators and showed strong ROC performance for distinguishing CRSwNP-related samples.	0.5963
37466964	Asian Pacific journal of allergy and immunology	2023	"Gene expression profiles of mRNA, lncRNA, miRNA, and circRNA and their clinical implications in chronic rhinosinusitis with nasal polyps."	hsa_circ_0038484	circ_0038484			chronic rhinosinusitis	MONDO:0006031	chronic rhinosinusitis	dysregulated	RNA-seq	"circ_0038484 was selected as a differentially expressed circRNA candidate, but its RNA-seq and RT-qPCR expression directions were inconsistent. The study did not establish a specific mechanism, clinical value, or functional role for circ_0038484."	0.329
37467831	International journal of biological macromolecules	2023	"N6-methyladenosine-modified circIRF2, identified by YTHDF2, suppresses liver fibrosis via facilitating FOXO3 nuclear translocation."	mmu_circ_0001674	circIRF2	mmu_circ_IRF2	IRF2	liver fibrosis	MONDO:0005155	cirrhosis of liver	down-regulated	RT-qPCR; RNA-seq	"circIRF2 is down-regulated during liver fibrogenesis and in human fibrotic liver tissues, while restored during fibrosis resolution. Functionally, circIRF2 suppresses liver fibrosis by inhibiting HSC activation and proliferation, promoting apoptosis, reducing collagen deposition and inflammation, and facilitating resolution. Mechanistically, YTHDF2 recognizes m6A-modified circIRF2 and decreases its stability, whereas cytoplasmic circIRF2 sponges miR-29b-1-5p to relieve repression of FOXO3 and promote FOXO3 nuclear translocation."	0.8885
37470573	Journal of cancer research and therapeutics	2023	Screening differential circular RNA expression profiles and the potential role of hsa_circ_0085465 in liver cancer.	hsa_circ_0085465		hsa_circ_ATAD2	ATAD2	liver cancer	MONDO:0002691	liver cancer	up-regulated	RT-qPCR; RNA-seq	"hsa_circ_0085465 is up-regulated in liver cancer serum, tissues, and liver cancer cell lines. The study functionally showed that overexpression of hsa_circ_0085465 promotes proliferation, migration, and invasion of 97 L liver cancer cells, suggesting relevance to liver cancer progression and biomarker potential."	0.6949
37470948	International journal of clinical oncology	2023	Circ_0000419 acts as a tumor suppressor in gastric cancer development via regulating miR-300/RGMB axis.	hsa_circ_0000419	circ_0000419	hsa_circ_RAB3IP	RAB3IP	gastric cancer / GC	MONDO:0001056	gastric cancer	down-regulated	RT-qPCR	"In this study, circ_0000419 was downregulated in gastric cancer tissues and cell lines. Its overexpression suppressed GC cell migration, invasion, glycolysis and xenograft tumor growth by acting as a sponge for miR-300 and upregulating RGMB, suggesting a tumor-suppressive role and potential therapeutic relevance."	0.7032
37474742	General thoracic and cardiovascular surgery	2024	CircRUNX1 drives the malignant phenotypes of lung adenocarcinoma through mediating the miR-5195-3p/HMGB3 network.	hsa_circ_0002360	circRUNX1	hsa_circ_RUNX1	RUNX1	lung adenocarcinoma / LUAD	MONDO:0005061	lung adenocarcinoma	up-regulated	RT-qPCR	"circRUNX1 is up-regulated in LUAD tissues and cells and high expression is associated with poorer overall survival. Functionally, circRUNX1 promotes LUAD proliferation, migration, invasion, metastasis and xenograft tumorigenesis while suppressing apoptosis. Mechanistically, it sponges miR-5195-3p to positively regulate HMGB3 through the circRUNX1/miR-5195-3p/HMGB3 ceRNA axis."	0.8427